Guide to the Human Genome
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Search of human proteins with 209364623

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
         (433 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]          891   0.0  
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]            877   0.0  
gi|4757980 beta chimerin isoform 2 [Homo sapiens]                     664   0.0  
gi|91106928 beta chimerin isoform 1 [Homo sapiens]                    426   e-119
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa...   139   7e-33
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap...   139   7e-33
gi|23510413 sorting nexin 26 [Homo sapiens]                           136   3e-32
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]           135   7e-32
gi|156119615 myosin IXA [Homo sapiens]                                134   2e-31
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]          134   2e-31
gi|188497642 ARHGAP15 [Homo sapiens]                                  132   6e-31
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]          129   4e-30
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]        129   4e-30
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]        129   4e-30
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi...   128   9e-30
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi...   128   9e-30
gi|194272142 myosin IXB isoform 2 [Homo sapiens]                      127   3e-29
gi|33356170 myosin IXB isoform 1 [Homo sapiens]                       127   3e-29
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]           127   3e-29
gi|229094128 active breakpoint cluster region-related  protein i...   126   3e-29
gi|38679957 active breakpoint cluster region-related  protein is...   126   3e-29
gi|38679954 active breakpoint cluster region-related  protein is...   126   3e-29
gi|208022687 GTPase regulator associated with the focal adhesion...   126   3e-29
gi|7662208 GTPase regulator associated with the focal adhesion k...   126   3e-29
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ...   126   4e-29
gi|91208437 GEM interacting protein [Homo sapiens]                    126   4e-29
gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]           125   7e-29
gi|186910302 Rac GTPase activating protein 1 [Homo sapiens]           122   8e-28
gi|186910300 Rac GTPase activating protein 1 [Homo sapiens]           122   8e-28
gi|21361397 Rac GTPase activating protein 1 [Homo sapiens]            122   8e-28

>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
          Length = 433

 Score =  891 bits (2303), Expect = 0.0
 Identities = 433/433 (100%), Positives = 433/433 (100%)

Query: 1   MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAAD 60
           MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAAD
Sbjct: 1   MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAAD 60

Query: 61  QLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDG 120
           QLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDG
Sbjct: 61  QLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDG 120

Query: 121 LITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVS 180
           LITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVS
Sbjct: 121 LITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVS 180

Query: 181 EKRVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVY 240
           EKRVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVY
Sbjct: 181 EKRVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVY 240

Query: 241 SCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKA 300
           SCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKA
Sbjct: 241 SCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKA 300

Query: 301 DISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLL 360
           DISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLL
Sbjct: 301 DISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLL 360

Query: 361 PPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRL 420
           PPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRL
Sbjct: 361 PPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRL 420

Query: 421 VVELLIKNEDILF 433
           VVELLIKNEDILF
Sbjct: 421 VVELLIKNEDILF 433


>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
          Length = 459

 Score =  877 bits (2266), Expect = 0.0
 Identities = 433/459 (94%), Positives = 433/459 (94%), Gaps = 26/459 (5%)

Query: 1   MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAAD 60
           MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAAD
Sbjct: 1   MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAAD 60

Query: 61  QLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDG 120
           QLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDG
Sbjct: 61  QLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDG 120

Query: 121 LITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVS 180
           LITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVS
Sbjct: 121 LITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVS 180

Query: 181 EKR--------------------------VHTFRGPHWCEYCANFMWGLIAQGVKCADCG 214
           EKR                          VHTFRGPHWCEYCANFMWGLIAQGVKCADCG
Sbjct: 181 EKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCG 240

Query: 215 LNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSE 274
           LNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSE
Sbjct: 241 LNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSE 300

Query: 275 GLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAY 334
           GLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAY
Sbjct: 301 GLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAY 360

Query: 335 PKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGI 394
           PKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGI
Sbjct: 361 PKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGI 420

Query: 395 VFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 433
           VFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF
Sbjct: 421 VFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 459


>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
          Length = 468

 Score =  664 bits (1713), Expect = 0.0
 Identities = 321/452 (71%), Positives = 371/452 (82%), Gaps = 25/452 (5%)

Query: 7   DTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAADQLLIVA 66
           D +EY+PP+WKSYLYQLQQEAP P+RI C  EVENRPKYYGREFHG+ISRE AD+LL   
Sbjct: 17  DAEEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKYYGREFHGIISREQADELLGGV 76

Query: 67  EGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDGLITLYI 126
           EG+Y++RESQRQPG YTLALRFG+QT N+RL++DGKHFVGEKRFESIHDLVTDGLITLYI
Sbjct: 77  EGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRFESIHDLVTDGLITLYI 136

Query: 127 ETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKE------THDERDSTGQDGVS 180
           ETKAAEYI+KMT NPIYEH+GY TL RE   ++      E      TH+E  +  +    
Sbjct: 137 ETKAAEYISKMTTNPIYEHIGYATLLREKVSRRLSRSKNEPRKTNVTHEEHTAVEKISSL 196

Query: 181 EKR-------------------VHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQC 221
            +R                   VHTFRGPHWCEYCANFMWGLIAQGV+C+DCGLNVHKQC
Sbjct: 197 VRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQC 256

Query: 222 SKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSG 281
           SK VPNDC+PDLK +KKVY CDLTTLVKAH T+RPMVVD+CIREIE+RGL SEGLYRVSG
Sbjct: 257 SKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSG 316

Query: 282 FSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESA 341
           F++ IEDVKMAFDRDGEKADIS N+Y DINIITGALKLYFRDLPIP+ITYD Y KFI++A
Sbjct: 317 FTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAA 376

Query: 342 KIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLM 401
           KI + DE+LE +HE L LLPPAH ETLRYLM HLK+VT++EK+N MNAENLGIVFGPTLM
Sbjct: 377 KISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLM 436

Query: 402 RSPELDAMAALNDIRYQRLVVELLIKNEDILF 433
           R PE   +  L+D+RYQ+L+V++LI+NED+LF
Sbjct: 437 RPPEDSTLTTLHDMRYQKLIVQILIENEDVLF 468


>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
          Length = 332

 Score =  426 bits (1096), Expect = e-119
 Identities = 197/251 (78%), Positives = 227/251 (90%)

Query: 183 RVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSC 242
           +VHTFRGPHWCEYCANFMWGLIAQGV+C+DCGLNVHKQCSK VPNDC+PDLK +KKVY C
Sbjct: 82  KVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCC 141

Query: 243 DLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADI 302
           DLTTLVKAH T+RPMVVD+CIREIE+RGL SEGLYRVSGF++ IEDVKMAFDRDGEKADI
Sbjct: 142 DLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADI 201

Query: 303 SVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPP 362
           S N+Y DINIITGALKLYFRDLPIP+ITYD Y KFI++AKI + DE+LE +HE L LLPP
Sbjct: 202 SANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPP 261

Query: 363 AHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVV 422
           AH ETLRYLM HLK+VT++EK+N MNAENLGIVFGPTLMR PE   +  L+D+RYQ+L+V
Sbjct: 262 AHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIV 321

Query: 423 ELLIKNEDILF 433
           ++LI+NED+LF
Sbjct: 322 QILIENEDVLF 332


>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
           sapiens]
          Length = 521

 Score =  139 bits (349), Expect = 7e-33
 Identities = 71/190 (37%), Positives = 119/190 (62%), Gaps = 2/190 (1%)

Query: 238 KVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDG 297
           +V+ C L  L +   ++ P  V  CIR +E+RGL+ +GLYR+SG    I+ ++   D D 
Sbjct: 325 QVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHD- 383

Query: 298 EKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 357
           E+ D+    +ED+++ITGALKL+FR+LP PL  +  + +FI + K+ D   +   + + +
Sbjct: 384 ERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLV 443

Query: 358 KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRY 417
           + LP  + +TLR L  HL RV  H ++N M+ +++ IVFGPTL+R PE++  +    + +
Sbjct: 444 RSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR-PEVEETSMPMTMVF 502

Query: 418 QRLVVELLIK 427
           Q  VVEL+++
Sbjct: 503 QNQVVELILQ 512


>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
           sapiens]
          Length = 548

 Score =  139 bits (349), Expect = 7e-33
 Identities = 71/190 (37%), Positives = 119/190 (62%), Gaps = 2/190 (1%)

Query: 238 KVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDG 297
           +V+ C L  L +   ++ P  V  CIR +E+RGL+ +GLYR+SG    I+ ++   D D 
Sbjct: 352 QVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHD- 410

Query: 298 EKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 357
           E+ D+    +ED+++ITGALKL+FR+LP PL  +  + +FI + K+ D   +   + + +
Sbjct: 411 ERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLV 470

Query: 358 KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRY 417
           + LP  + +TLR L  HL RV  H ++N M+ +++ IVFGPTL+R PE++  +    + +
Sbjct: 471 RSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR-PEVEETSMPMTMVF 529

Query: 418 QRLVVELLIK 427
           Q  VVEL+++
Sbjct: 530 QNQVVELILQ 539


>gi|23510413 sorting nexin 26 [Homo sapiens]
          Length = 1126

 Score =  136 bits (343), Expect = 3e-32
 Identities = 74/202 (36%), Positives = 116/202 (57%), Gaps = 6/202 (2%)

Query: 237 KKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRD 296
           ++V+ CDL   +       P V+  C   IE+ G+  +G+YR+SG S  I+ ++  FD +
Sbjct: 310 QRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGV-VDGIYRLSGVSSNIQRLRHEFDSE 368

Query: 297 GEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEA 356
                      +DI+ ++   KLYFR+LP PL+TY  Y KF E+  +   +E+L  +H+ 
Sbjct: 369 RIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDV 428

Query: 357 LKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAM-----AA 411
           ++ LPP H  TL YL+ HL R+  H     M+A NL IV+ P L+RS EL+++     AA
Sbjct: 429 IQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAA 488

Query: 412 LNDIRYQRLVVELLIKNEDILF 433
             ++R Q +VVE L+ + D+LF
Sbjct: 489 FREVRVQSVVVEFLLTHVDVLF 510


>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
          Length = 786

 Score =  135 bits (340), Expect = 7e-32
 Identities = 72/178 (40%), Positives = 111/178 (62%), Gaps = 3/178 (1%)

Query: 258 VVDMCIREIESRGLNSEGLYRVSGFSDLIEDV-KMAFD-RDGEKADISVNMYEDINIITG 315
           ++  CI  +E+RG+N +GLYRV G S  ++ +  M  D +   + D+  +   ++  IT 
Sbjct: 398 IIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITS 457

Query: 316 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 375
           ALK Y R LP PL+TY+ +  FI  AK   P+ ++  +H  +  LP  + E L  L+ HL
Sbjct: 458 ALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHL 517

Query: 376 KRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 433
             V+ H K+NLM   NLG+VFGPTLMR P+ + +AAL D+++Q +VVE+LI+N + +F
Sbjct: 518 TNVSNHSKQNLMTVANLGVVFGPTLMR-PQEETVAALMDLKFQNIVVEILIENHEKIF 574


>gi|156119615 myosin IXA [Homo sapiens]
          Length = 2548

 Score =  134 bits (336), Expect = 2e-31
 Identities = 85/273 (31%), Positives = 139/273 (50%), Gaps = 15/273 (5%)

Query: 163  VLKETHDERDSTGQDGVSEKRVHTFRG-----PHWCEYCANFMWGLIAQGVKCADCGLNV 217
            V K    +R     D V E   H F+      P +CEYC++ +W ++ +   C  C    
Sbjct: 1978 VPKTERKKRRKKETDLVEEHNGHIFKATQYSIPTYCEYCSSLIW-IMDRASVCKLCKYAC 2036

Query: 218  HKQCSKMVPNDC--KPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEG 275
            HK+C       C  K D +   + +  +L+ L     T  P+VV+  I  IE  GL +EG
Sbjct: 2037 HKKCCLKTTAKCSKKYDPELSSRQFGVELSRLTSEDRTV-PLVVEKLINYIEMHGLYTEG 2095

Query: 276  LYRVSGFSDLIEDVKMAFDRDGEKADISVNMYE-DINIITGALKLYFRDLPIPLITYDAY 334
            +YR SG ++ I++++   D D E    SVN+ + +I++I    K + RDLP PL+T++ Y
Sbjct: 2096 IYRKSGSTNKIKELRQGLDTDAE----SVNLDDYNIHVIASVFKQWLRDLPNPLMTFELY 2151

Query: 335  PKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGI 394
             +F+ +  + +  E +  ++  +  L   H  TL  L+ HL R+ L E  N M+A  L I
Sbjct: 2152 EEFLRAMGLQERKETIRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAI 2211

Query: 395  VFGPTLMRSPE-LDAMAALNDIRYQRLVVELLI 426
            VF P ++R P+  D + ++ DI      VEL++
Sbjct: 2212 VFAPCILRCPDTTDPLQSVQDISKTTTCVELIV 2244


>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
          Length = 1958

 Score =  134 bits (336), Expect = 2e-31
 Identities = 73/185 (39%), Positives = 110/185 (59%), Gaps = 1/185 (0%)

Query: 250  AHTTKR-PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYE 308
            AHT +  P++VD+C + +E RGL   G+YRV G +  I  ++   ++     DI  + + 
Sbjct: 1155 AHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWR 1214

Query: 309  DINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETL 368
            D+N+I+  LK +FR LP PL T D Y  FIE+ +  DP ++L+TL   +  LP  H ETL
Sbjct: 1215 DLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETL 1274

Query: 369  RYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKN 428
            ++L AHLK V  + ++N M   NL IVFGPTL+R+ E +    +  +  Q  +VE LI++
Sbjct: 1275 KFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQH 1334

Query: 429  EDILF 433
             D  F
Sbjct: 1335 HDWFF 1339


>gi|188497642 ARHGAP15 [Homo sapiens]
          Length = 475

 Score =  132 bits (332), Expect = 6e-31
 Identities = 64/196 (32%), Positives = 119/196 (60%), Gaps = 2/196 (1%)

Query: 238 KVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDG 297
           +++   L  + +   +  P  V  CI  +E RGL+ +G+YRVSG    I+ ++   +++ 
Sbjct: 277 QIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQE- 335

Query: 298 EKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 357
           EK ++  + +EDI+++TGALK++FR+LP PL  Y  + +F+E+ K  D + ++E +   +
Sbjct: 336 EKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLV 395

Query: 358 KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRY 417
           + LPP + +T++ L  HL ++     +NLM+ ++LGIVFGPTL+R+       A++ + Y
Sbjct: 396 QKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMV-Y 454

Query: 418 QRLVVELLIKNEDILF 433
           Q  + EL++     +F
Sbjct: 455 QNQIAELMLSEYSKIF 470


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score =  129 bits (325), Expect = 4e-30
 Identities = 71/208 (34%), Positives = 118/208 (56%), Gaps = 1/208 (0%)

Query: 227  NDCKPDLKHVKKVYSCDLTTLVKAHTTKR-PMVVDMCIREIESRGLNSEGLYRVSGFSDL 285
            N  K + K   + +   L     A   +R P++V  C R +E+RGL S G+YRV G + +
Sbjct: 796  NIIKKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAV 855

Query: 286  IEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMD 345
            +  ++   +R     ++    ++D+N+I+  LK +FR LP PL T D Y  FIE+ +I D
Sbjct: 856  VSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIED 915

Query: 346  PDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPE 405
              E++ TL + ++ LP  + ETL++L+ HLK +  H ++N M   NL +VFGPTL+R+ E
Sbjct: 916  ARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSE 975

Query: 406  LDAMAALNDIRYQRLVVELLIKNEDILF 433
             +    +  +  +  +VE LI++ D  F
Sbjct: 976  DNMTDMVTHMPDRYKIVETLIQHSDWFF 1003


>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
          Length = 1227

 Score =  129 bits (325), Expect = 4e-30
 Identities = 73/176 (41%), Positives = 100/176 (56%), Gaps = 3/176 (1%)

Query: 239  VYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGE 298
            V+   +  + K   +K P +V  C+ EIE RG+   G+YRVSG +  I+ +K AFD + +
Sbjct: 1007 VFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK 1066

Query: 299  KADISVNMYE-DINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 357
              D+SV M E D+N I G LKLYFR+LP PL T + YP F E   + DP  +   +   L
Sbjct: 1067 --DVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLL 1124

Query: 358  KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALN 413
              LP A+  T  +L+ HLKRV   E  N M+  NL  VFGPTL+R  E ++    N
Sbjct: 1125 LSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPAN 1180


>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
          Length = 1271

 Score =  129 bits (325), Expect = 4e-30
 Identities = 73/176 (41%), Positives = 100/176 (56%), Gaps = 3/176 (1%)

Query: 239  VYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGE 298
            V+   +  + K   +K P +V  C+ EIE RG+   G+YRVSG +  I+ +K AFD + +
Sbjct: 1051 VFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK 1110

Query: 299  KADISVNMYE-DINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 357
              D+SV M E D+N I G LKLYFR+LP PL T + YP F E   + DP  +   +   L
Sbjct: 1111 --DVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLL 1168

Query: 358  KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALN 413
              LP A+  T  +L+ HLKRV   E  N M+  NL  VFGPTL+R  E ++    N
Sbjct: 1169 LSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPAN 1224


>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
          Length = 1502

 Score =  128 bits (322), Expect = 9e-30
 Identities = 71/178 (39%), Positives = 104/178 (58%), Gaps = 3/178 (1%)

Query: 256  PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 315
            P+ V+ C+  IE  GL +EGLYRVSG     ++++  FD+D     +S+ +   +N + G
Sbjct: 1275 PLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSMEV--TVNAVAG 1332

Query: 316  ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 375
            ALK +F DLP PLI Y  +P+ +E+AKI D  E+L  L E +K   P + +  RY++ HL
Sbjct: 1333 ALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHL 1392

Query: 376  KRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 433
             RV+   K NLM A+NL I F PTLMR P+ +    L+  +  + VVE  I+     F
Sbjct: 1393 NRVSQQHKINLMTADNLSICFWPTLMR-PDFENREFLSTTKIHQSVVETFIQQCQFFF 1449


>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
          Length = 1501

 Score =  128 bits (322), Expect = 9e-30
 Identities = 71/178 (39%), Positives = 104/178 (58%), Gaps = 3/178 (1%)

Query: 256  PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 315
            P+ V+ C+  IE  GL +EGLYRVSG     ++++  FD+D     +S+ +   +N + G
Sbjct: 1274 PLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSMEV--TVNAVAG 1331

Query: 316  ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 375
            ALK +F DLP PLI Y  +P+ +E+AKI D  E+L  L E +K   P + +  RY++ HL
Sbjct: 1332 ALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHL 1391

Query: 376  KRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 433
             RV+   K NLM A+NL I F PTLMR P+ +    L+  +  + VVE  I+     F
Sbjct: 1392 NRVSQQHKINLMTADNLSICFWPTLMR-PDFENREFLSTTKIHQSVVETFIQQCQFFF 1448


>gi|194272142 myosin IXB isoform 2 [Homo sapiens]
          Length = 2022

 Score =  127 bits (318), Expect = 3e-29
 Identities = 101/358 (28%), Positives = 169/358 (47%), Gaps = 30/358 (8%)

Query: 87   RFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHV 146
            +F S  +      +GK  VG K     + +V   L T   + K    +  +  + + E  
Sbjct: 1542 KFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQ-KDTNLVLNLFQSLLDEFT 1600

Query: 147  -GYTTLNREPAYKKHMPVLKETHDERDSTGQDGVSEKRVHTFRG-----PHWCEYCANFM 200
             GYT  + EP  K+     K+   ER       V E   H F       P  CE C +++
Sbjct: 1601 RGYTKNDFEPV-KQSKAQKKKRKQER------AVQEHNGHVFASYQVSIPQSCEQCLSYI 1653

Query: 201  WGLIAQGVKCADCGLNVHKQCSKMVPNDC--------KPDLKHVKKVYSCDLTTLVKAHT 252
            W L+ + + C+ C +  HK+C   + + C        +P ++        D  T  KA  
Sbjct: 1654 W-LMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSDKASV 1712

Query: 253  TKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINI 312
               P+V++  +  +E  GL +EGLYR SG ++   +++ A   D   A + +  +  I+ 
Sbjct: 1713 ---PIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTD--PAAVKLENFP-IHA 1766

Query: 313  ITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLM 372
            ITG LK + R+LP PL+T+  Y  F+ + ++ +  EQL  ++  L+ LP A+  +L  L+
Sbjct: 1767 ITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLI 1826

Query: 373  AHLKRVTLHEKENLMNAENLGIVFGPTLMRSPE-LDAMAALNDIRYQRLVVELLIKNE 429
             HL +V L E  N M+   L I+F P L+R P+  D + ++ D+      VE+LIK +
Sbjct: 1827 FHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQ 1884


>gi|33356170 myosin IXB isoform 1 [Homo sapiens]
          Length = 2157

 Score =  127 bits (318), Expect = 3e-29
 Identities = 101/358 (28%), Positives = 169/358 (47%), Gaps = 30/358 (8%)

Query: 87   RFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHV 146
            +F S  +      +GK  VG K     + +V   L T   + K    +  +  + + E  
Sbjct: 1542 KFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQ-KDTNLVLNLFQSLLDEFT 1600

Query: 147  -GYTTLNREPAYKKHMPVLKETHDERDSTGQDGVSEKRVHTFRG-----PHWCEYCANFM 200
             GYT  + EP  K+     K+   ER       V E   H F       P  CE C +++
Sbjct: 1601 RGYTKNDFEPV-KQSKAQKKKRKQER------AVQEHNGHVFASYQVSIPQSCEQCLSYI 1653

Query: 201  WGLIAQGVKCADCGLNVHKQCSKMVPNDC--------KPDLKHVKKVYSCDLTTLVKAHT 252
            W L+ + + C+ C +  HK+C   + + C        +P ++        D  T  KA  
Sbjct: 1654 W-LMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSDKASV 1712

Query: 253  TKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINI 312
               P+V++  +  +E  GL +EGLYR SG ++   +++ A   D   A + +  +  I+ 
Sbjct: 1713 ---PIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTD--PAAVKLENFP-IHA 1766

Query: 313  ITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLM 372
            ITG LK + R+LP PL+T+  Y  F+ + ++ +  EQL  ++  L+ LP A+  +L  L+
Sbjct: 1767 ITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLI 1826

Query: 373  AHLKRVTLHEKENLMNAENLGIVFGPTLMRSPE-LDAMAALNDIRYQRLVVELLIKNE 429
             HL +V L E  N M+   L I+F P L+R P+  D + ++ D+      VE+LIK +
Sbjct: 1827 FHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQ 1884


>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
          Length = 846

 Score =  127 bits (318), Expect = 3e-29
 Identities = 65/196 (33%), Positives = 122/196 (62%), Gaps = 3/196 (1%)

Query: 238 KVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDG 297
           +V+  +L  L +      P  V +CI  +E  GL+ +G+YRVSG   +I+ ++ A + D 
Sbjct: 652 QVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHD- 710

Query: 298 EKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 357
           EK D++ + +EDI++ITGALK++FR+LP PL T++ +  F+ + K  +P +++  + + +
Sbjct: 711 EKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIK-QEPRQRVAAVKDLI 769

Query: 358 KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRY 417
           + LP  + +T++ L  HL+RV  + ++N M  +++ IVFGPTL++  +     A++ + Y
Sbjct: 770 RQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTV-Y 828

Query: 418 QRLVVELLIKNEDILF 433
           Q  +VEL++     +F
Sbjct: 829 QNQIVELILLELSSIF 844


>gi|229094128 active breakpoint cluster region-related  protein
           isoform c [Homo sapiens]
          Length = 813

 Score =  126 bits (317), Expect = 3e-29
 Identities = 68/175 (38%), Positives = 102/175 (58%), Gaps = 3/175 (1%)

Query: 239 VYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGE 298
           V+   ++ + K   +K P +V  C+ E+E RG+   G+YR+SG +  I+ +K  FD + +
Sbjct: 598 VFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNK 657

Query: 299 KADISVNMYE-DINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 357
             DI + + + DIN I G LKLYFR+LP PL+T   YP F+E   + DP  +   +   L
Sbjct: 658 --DILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLL 715

Query: 358 KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAAL 412
           + LP  +  T  +L+ HLKRV   E  N M+  NL  VFGPTL+R  E+++ A L
Sbjct: 716 RSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHL 770


>gi|38679957 active breakpoint cluster region-related  protein
           isoform a [Homo sapiens]
          Length = 859

 Score =  126 bits (317), Expect = 3e-29
 Identities = 68/175 (38%), Positives = 102/175 (58%), Gaps = 3/175 (1%)

Query: 239 VYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGE 298
           V+   ++ + K   +K P +V  C+ E+E RG+   G+YR+SG +  I+ +K  FD + +
Sbjct: 644 VFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNK 703

Query: 299 KADISVNMYE-DINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 357
             DI + + + DIN I G LKLYFR+LP PL+T   YP F+E   + DP  +   +   L
Sbjct: 704 --DILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLL 761

Query: 358 KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAAL 412
           + LP  +  T  +L+ HLKRV   E  N M+  NL  VFGPTL+R  E+++ A L
Sbjct: 762 RSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHL 816


>gi|38679954 active breakpoint cluster region-related  protein
           isoform b [Homo sapiens]
          Length = 822

 Score =  126 bits (317), Expect = 3e-29
 Identities = 68/175 (38%), Positives = 102/175 (58%), Gaps = 3/175 (1%)

Query: 239 VYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGE 298
           V+   ++ + K   +K P +V  C+ E+E RG+   G+YR+SG +  I+ +K  FD + +
Sbjct: 607 VFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNK 666

Query: 299 KADISVNMYE-DINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 357
             DI + + + DIN I G LKLYFR+LP PL+T   YP F+E   + DP  +   +   L
Sbjct: 667 --DILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLL 724

Query: 358 KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAAL 412
           + LP  +  T  +L+ HLKRV   E  N M+  NL  VFGPTL+R  E+++ A L
Sbjct: 725 RSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHL 779


>gi|208022687 GTPase regulator associated with the focal adhesion
           kinase pp125 isoform b [Homo sapiens]
          Length = 759

 Score =  126 bits (317), Expect = 3e-29
 Identities = 63/178 (35%), Positives = 108/178 (60%), Gaps = 3/178 (1%)

Query: 258 VVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAF--DRDGEKADISVNMYEDINIITG 315
           ++  CI  +E+RG+N +GLYR+ G +  ++ +       +   + +  +    +I  IT 
Sbjct: 392 IIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAEWEIKTITS 451

Query: 316 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 375
           ALK Y R LP PL+ Y     FI++AK+ + + ++  +H  +  LP  + + L+ LM HL
Sbjct: 452 ALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHL 511

Query: 376 KRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 433
             V  + K+NLM   NLG+VFGPTL+R P+ + +AA+ DI++Q +V+E+LI+N + +F
Sbjct: 512 ANVANNHKQNLMTVANLGVVFGPTLLR-PQEETVAAIMDIKFQNIVIEILIENHEKIF 568


>gi|7662208 GTPase regulator associated with the focal adhesion
           kinase pp125 isoform a [Homo sapiens]
          Length = 814

 Score =  126 bits (317), Expect = 3e-29
 Identities = 63/178 (35%), Positives = 108/178 (60%), Gaps = 3/178 (1%)

Query: 258 VVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAF--DRDGEKADISVNMYEDINIITG 315
           ++  CI  +E+RG+N +GLYR+ G +  ++ +       +   + +  +    +I  IT 
Sbjct: 392 IIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAEWEIKTITS 451

Query: 316 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 375
           ALK Y R LP PL+ Y     FI++AK+ + + ++  +H  +  LP  + + L+ LM HL
Sbjct: 452 ALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHL 511

Query: 376 KRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 433
             V  + K+NLM   NLG+VFGPTL+R P+ + +AA+ DI++Q +V+E+LI+N + +F
Sbjct: 512 ANVANNHKQNLMTVANLGVVFGPTLLR-PQEETVAAIMDIKFQNIVIEILIENHEKIF 568


>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
            sapiens]
          Length = 1499

 Score =  126 bits (316), Expect = 4e-29
 Identities = 71/194 (36%), Positives = 113/194 (58%), Gaps = 4/194 (2%)

Query: 240  YSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEK 299
            +   LTT+V       P+ ++ CI  IE+ GL++EG+YRVSG    +E ++  FD+D   
Sbjct: 1247 FGVPLTTVVTPEKPI-PIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQD-HN 1304

Query: 300  ADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKL 359
             D++   +  +N + GA+K +F +LP PL+ Y+     +E+ KI D +++L  L E LK 
Sbjct: 1305 LDLAEKDFT-VNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKK 1363

Query: 360  LPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQR 419
             P  + E  +Y+++HL +V+ + K NLM +ENL I F PTLMR P+   M AL   R  +
Sbjct: 1364 FPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMR-PDFSTMDALTATRTYQ 1422

Query: 420  LVVELLIKNEDILF 433
             ++EL I+     F
Sbjct: 1423 TIIELFIQQCPFFF 1436


>gi|91208437 GEM interacting protein [Homo sapiens]
          Length = 970

 Score =  126 bits (316), Expect = 4e-29
 Identities = 89/270 (32%), Positives = 132/270 (48%), Gaps = 26/270 (9%)

Query: 183 RVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDC-KPDLKHVKKVYS 241
           ++   RGP  C  C  FM      G +C +C L  HK+C + +   C    L     ++ 
Sbjct: 495 QLRRLRGPAKCRECEAFM----VSGTECEECFLTCHKRCLETLLILCGHRRLPARTPLFG 550

Query: 242 CDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKAD 301
            D   L +    + P VV  C  EIE R L+ +G+YRVSG    +E +  AF+      +
Sbjct: 551 VDFLQLPRDFPEEVPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRALVE 610

Query: 302 ISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPD------------EQ 349
           +S N   D++ +   LK + ++L  P+I +  Y  FI  AK +  D            E 
Sbjct: 611 LSGNSPHDVSSV---LKRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGTPSPSPEV 667

Query: 350 LETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAM 409
           + +L   L  LP ++  TLR+L+AHL RV     EN M+A NLGIVFGPTL+R P+    
Sbjct: 668 IRSLKTLLVQLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLRPPDGPRA 727

Query: 410 AA------LNDIRYQRLVVELLIKNEDILF 433
           A+      L D  +Q  +VE LI + + +F
Sbjct: 728 ASAIPVTCLLDSGHQAQLVEFLIVHYEQIF 757


>gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
          Length = 1444

 Score =  125 bits (314), Expect = 7e-29
 Identities = 69/206 (33%), Positives = 116/206 (56%), Gaps = 8/206 (3%)

Query: 234 KHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAF 293
           K     + CDLT  +++     P V+  C   IE+ G+  +G+YR+SG +  I+ ++  F
Sbjct: 13  KGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEF 71

Query: 294 DRDGEKADISVNMY-EDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLET 352
             D +  D++  +Y +DI+ +    KLYFR+LP PL+TY+ Y KF E+      + QL  
Sbjct: 72  GSD-QCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLAR 130

Query: 353 LHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAM--- 409
           +   ++ LPP+H  TL YL+ HL  +     +  M+A NL +V+ P L+RS E++A    
Sbjct: 131 IQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCN 190

Query: 410 --AALNDIRYQRLVVELLIKNEDILF 433
             AA   +R Q++V+E ++ + D +F
Sbjct: 191 GDAAFLAVRVQQVVIEFILNHVDQIF 216


>gi|186910302 Rac GTPase activating protein 1 [Homo sapiens]
          Length = 632

 Score =  122 bits (305), Expect = 8e-28
 Identities = 90/271 (33%), Positives = 132/271 (48%), Gaps = 15/271 (5%)

Query: 166 ETHDERDSTGQ-DGVSEKRVHTFRG-----PHWCEYCAN-FMWGLIAQGVKCADCGLNVH 218
           E   E DS G        R+H F       P  C  C     +G ++  +KC DC +  H
Sbjct: 267 EPRTETDSVGTPQSNGGMRLHDFVSKTVIKPESCVPCGKRIKFGKLS--LKCRDCRVVSH 324

Query: 219 KQCSKMVPNDCKPDLKHVK-KVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLY 277
            +C    P  C P L     K+    L   V   +   P +V  C+ EIE RGL   GLY
Sbjct: 325 PECRDRCPLPCIPTLIGTPVKIGEGMLADFVSQTSPMIPSIVVHCVNEIEQRGLTETGLY 384

Query: 278 RVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKF 337
           R+SG    ++++K  F R   K    ++  +DI+ I   LK + R+L  PL+T+     F
Sbjct: 385 RISGCDRTVKELKEKFLR--VKTVPLLSKVDDIHAICSLLKDFLRNLKEPLLTFRLNRAF 442

Query: 338 IESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFG 397
           +E+A+I D D  +  +++A+  LP A+ +TL +LM HL+RV        M+  NL  VFG
Sbjct: 443 MEAAEITDEDNSIAAMYQAVGELPQANRDTLAFLMIHLQRVA-QSPHTKMDVANLAKVFG 501

Query: 398 PTLMRS--PELDAMAALNDIRYQRLVVELLI 426
           PT++    P  D +  L DI+ Q  VVE L+
Sbjct: 502 PTIVAHAVPNPDPVTMLQDIKRQPKVVERLL 532


>gi|186910300 Rac GTPase activating protein 1 [Homo sapiens]
          Length = 632

 Score =  122 bits (305), Expect = 8e-28
 Identities = 90/271 (33%), Positives = 132/271 (48%), Gaps = 15/271 (5%)

Query: 166 ETHDERDSTGQ-DGVSEKRVHTFRG-----PHWCEYCAN-FMWGLIAQGVKCADCGLNVH 218
           E   E DS G        R+H F       P  C  C     +G ++  +KC DC +  H
Sbjct: 267 EPRTETDSVGTPQSNGGMRLHDFVSKTVIKPESCVPCGKRIKFGKLS--LKCRDCRVVSH 324

Query: 219 KQCSKMVPNDCKPDLKHVK-KVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLY 277
            +C    P  C P L     K+    L   V   +   P +V  C+ EIE RGL   GLY
Sbjct: 325 PECRDRCPLPCIPTLIGTPVKIGEGMLADFVSQTSPMIPSIVVHCVNEIEQRGLTETGLY 384

Query: 278 RVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKF 337
           R+SG    ++++K  F R   K    ++  +DI+ I   LK + R+L  PL+T+     F
Sbjct: 385 RISGCDRTVKELKEKFLR--VKTVPLLSKVDDIHAICSLLKDFLRNLKEPLLTFRLNRAF 442

Query: 338 IESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFG 397
           +E+A+I D D  +  +++A+  LP A+ +TL +LM HL+RV        M+  NL  VFG
Sbjct: 443 MEAAEITDEDNSIAAMYQAVGELPQANRDTLAFLMIHLQRVA-QSPHTKMDVANLAKVFG 501

Query: 398 PTLMRS--PELDAMAALNDIRYQRLVVELLI 426
           PT++    P  D +  L DI+ Q  VVE L+
Sbjct: 502 PTIVAHAVPNPDPVTMLQDIKRQPKVVERLL 532


>gi|21361397 Rac GTPase activating protein 1 [Homo sapiens]
          Length = 632

 Score =  122 bits (305), Expect = 8e-28
 Identities = 90/271 (33%), Positives = 132/271 (48%), Gaps = 15/271 (5%)

Query: 166 ETHDERDSTGQ-DGVSEKRVHTFRG-----PHWCEYCAN-FMWGLIAQGVKCADCGLNVH 218
           E   E DS G        R+H F       P  C  C     +G ++  +KC DC +  H
Sbjct: 267 EPRTETDSVGTPQSNGGMRLHDFVSKTVIKPESCVPCGKRIKFGKLS--LKCRDCRVVSH 324

Query: 219 KQCSKMVPNDCKPDLKHVK-KVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLY 277
            +C    P  C P L     K+    L   V   +   P +V  C+ EIE RGL   GLY
Sbjct: 325 PECRDRCPLPCIPTLIGTPVKIGEGMLADFVSQTSPMIPSIVVHCVNEIEQRGLTETGLY 384

Query: 278 RVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKF 337
           R+SG    ++++K  F R   K    ++  +DI+ I   LK + R+L  PL+T+     F
Sbjct: 385 RISGCDRTVKELKEKFLR--VKTVPLLSKVDDIHAICSLLKDFLRNLKEPLLTFRLNRAF 442

Query: 338 IESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFG 397
           +E+A+I D D  +  +++A+  LP A+ +TL +LM HL+RV        M+  NL  VFG
Sbjct: 443 MEAAEITDEDNSIAAMYQAVGELPQANRDTLAFLMIHLQRVA-QSPHTKMDVANLAKVFG 501

Query: 398 PTLMRS--PELDAMAALNDIRYQRLVVELLI 426
           PT++    P  D +  L DI+ Q  VVE L+
Sbjct: 502 PTIVAHAVPNPDPVTMLQDIKRQPKVVERLL 532


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,568,246
Number of Sequences: 37866
Number of extensions: 736494
Number of successful extensions: 3475
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 201
Number of HSP's successfully gapped in prelim test: 163
Number of HSP's that attempted gapping in prelim test: 2748
Number of HSP's gapped (non-prelim): 704
length of query: 433
length of database: 18,247,518
effective HSP length: 105
effective length of query: 328
effective length of database: 14,271,588
effective search space: 4681080864
effective search space used: 4681080864
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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