Guide to the Human Genome
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Search of human proteins with 205360905

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|205360905 testis-specific serine protease 1 [Homo sapiens]
         (318 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|205360905 testis-specific serine protease 1 [Homo sapiens]         673   0.0  
gi|21614531 testisin isoform 2 [Homo sapiens]                         336   1e-92
gi|5803197 testisin isoform 1 [Homo sapiens]                          336   2e-92
gi|21614533 testisin isoform 3 [Homo sapiens]                         314   6e-86
gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]      221   5e-58
gi|4506153 prostasin preproprotein [Homo sapiens]                     213   2e-55
gi|58218970 protease, serine, 36 [Homo sapiens]                       202   4e-52
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   197   8e-51
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          197   1e-50
gi|117956391 protease, serine, 33 [Homo sapiens]                      193   1e-49
gi|148806900 epidermis-specific serine protease-like protein [Ho...   193   2e-49
gi|13994276 marapsin [Homo sapiens]                                   188   5e-48
gi|11545839 protease, serine, 22 [Homo sapiens]                       186   3e-47
gi|187761337 transmembrane protease, serine 11B [Homo sapiens]        185   5e-47
gi|239753545 PREDICTED: similar to hCG2041452 [Homo sapiens]          183   2e-46
gi|239748117 PREDICTED: hypothetical protein XP_002346556 [Homo ...   183   2e-46
gi|239742016 PREDICTED: hypothetical protein XP_002342392 [Homo ...   183   2e-46
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   182   3e-46
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   182   3e-46
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           179   2e-45
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   175   4e-44
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   175   4e-44
gi|223942069 enterokinase precursor [Homo sapiens]                    174   1e-43
gi|40254871 transmembrane protease, serine 11E [Homo sapiens]         172   5e-43
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]       172   5e-43
gi|68508970 tryptase beta 2 precursor [Homo sapiens]                  171   6e-43
gi|194018492 transmembrane protease, serine 11F [Homo sapiens]        171   6e-43
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         171   8e-43
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             171   1e-42
gi|4503627 coagulation factor XI precursor [Homo sapiens]             169   3e-42

>gi|205360905 testis-specific serine protease 1 [Homo sapiens]
          Length = 318

 Score =  673 bits (1736), Expect = 0.0
 Identities = 318/318 (100%), Positives = 318/318 (100%)

Query: 1   MGARGALLLALLLARAGLGKPGELGALQAGPGAARRPGGGGREEACGHREIHALVAGGVE 60
           MGARGALLLALLLARAGLGKPGELGALQAGPGAARRPGGGGREEACGHREIHALVAGGVE
Sbjct: 1   MGARGALLLALLLARAGLGKPGELGALQAGPGAARRPGGGGREEACGHREIHALVAGGVE 60

Query: 61  SARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELTSRPTPW 120
           SARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELTSRPTPW
Sbjct: 61  SARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELTSRPTPW 120

Query: 121 NLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPD 180
           NLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPD
Sbjct: 121 NLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPD 180

Query: 181 CWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGAEDG 240
           CWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGAEDG
Sbjct: 181 CWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGAEDG 240

Query: 241 SVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVMSHST 300
           SVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVMSHST
Sbjct: 241 SVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVMSHST 300

Query: 301 PRPNPSQLLLLLALLWAP 318
           PRPNPSQLLLLLALLWAP
Sbjct: 301 PRPNPSQLLLLLALLWAP 318


>gi|21614531 testisin isoform 2 [Homo sapiens]
          Length = 312

 Score =  336 bits (862), Expect = 1e-92
 Identities = 172/320 (53%), Positives = 217/320 (67%), Gaps = 18/320 (5%)

Query: 1   MGARGALLLALLLARAGLGKP-GELGALQAGPGAARRPGGGGREEACGHREIHALVAGGV 59
           MGARGALLLALLLARAGL KP  +  A  +GP              CG R I + + GG 
Sbjct: 1   MGARGALLLALLLARAGLRKPESQEAAPLSGP--------------CGRRVITSRIVGGE 46

Query: 60  ESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYY-PSEWTVQLGELTSRPT 118
           ++  GRWPWQ SLRL   H CG SLLS RW L+AAHCF+     PS W VQ G+LTS P+
Sbjct: 47  DAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFGQLTSMPS 106

Query: 119 PWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHR 178
            W+L+AY +RY V +I ++P  LG    DIAL++L++ VTY  +IQPIC+++STF F +R
Sbjct: 107 FWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENR 166

Query: 179 PDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGAE 238
            DCWVTGWG I      LP P+ L+E QV I+NN+ CN+LF + S R  I+  M CAG  
Sbjct: 167 TDCWVTGWGYIKEDEA-LPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNA 225

Query: 239 DGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVMSH 298
            G  D C GDSGGPL C+K+GLWYQ+G+VSWG+ CG+PNRPGVYTNIS +F WI+++M+ 
Sbjct: 226 QGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQ 285

Query: 299 S-TPRPNPSQLLLLLALLWA 317
           S   +P+PS  LL   LLWA
Sbjct: 286 SGMSQPDPSWPLLFFPLLWA 305


>gi|5803197 testisin isoform 1 [Homo sapiens]
          Length = 314

 Score =  336 bits (861), Expect = 2e-92
 Identities = 172/322 (53%), Positives = 218/322 (67%), Gaps = 20/322 (6%)

Query: 1   MGARGALLLALLLARAGLGKP-GELGALQAGPGAARRPGGGGREEACGHREIHALVAGGV 59
           MGARGALLLALLLARAGL KP  +  A  +GP              CG R I + + GG 
Sbjct: 1   MGARGALLLALLLARAGLRKPESQEAAPLSGP--------------CGRRVITSRIVGGE 46

Query: 60  ESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYY---PSEWTVQLGELTSR 116
           ++  GRWPWQ SLRL   H CG SLLS RW L+AAHCF+ +     PS W VQ G+LTS 
Sbjct: 47  DAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWMVQFGQLTSM 106

Query: 117 PTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFV 176
           P+ W+L+AY +RY V +I ++P  LG    DIAL++L++ VTY  +IQPIC+++STF F 
Sbjct: 107 PSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFE 166

Query: 177 HRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAG 236
           +R DCWVTGWG I      LP P+ L+E QV I+NN+ CN+LF + S R  I+  M CAG
Sbjct: 167 NRTDCWVTGWGYIKEDEA-LPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAG 225

Query: 237 AEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVM 296
              G  D C GDSGGPL C+K+GLWYQ+G+VSWG+ CG+PNRPGVYTNIS +F WI+++M
Sbjct: 226 NAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLM 285

Query: 297 SHS-TPRPNPSQLLLLLALLWA 317
           + S   +P+PS  LL   LLWA
Sbjct: 286 AQSGMSQPDPSWPLLFFPLLWA 307


>gi|21614533 testisin isoform 3 [Homo sapiens]
          Length = 300

 Score =  314 bits (805), Expect = 6e-86
 Identities = 166/322 (51%), Positives = 212/322 (65%), Gaps = 34/322 (10%)

Query: 1   MGARGALLLALLLARAGLGKP-GELGALQAGPGAARRPGGGGREEACGHREIHALVAGGV 59
           MGARGALLLALLLARAGL KP  +  A  +GP              CG R I + + GG 
Sbjct: 1   MGARGALLLALLLARAGLRKPESQEAAPLSGP--------------CGRRVITSRIVGGE 46

Query: 60  ESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYY---PSEWTVQLGELTSR 116
           ++  GRWPWQ SLRL   H CG SLLS RW L+AAHCF+ +     PS W VQ G+LTS 
Sbjct: 47  DAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWMVQFGQLTSM 106

Query: 117 PTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFV 176
           P+ W+L+AY +RY V +I ++P  LG    DIAL++L++ VTY  +IQPIC+++STF F 
Sbjct: 107 PSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFE 166

Query: 177 HRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAG 236
           +R DCWVTGWG I      LP P+ L+E QV I+NN+ CN+LF + S R  I+  M    
Sbjct: 167 NRTDCWVTGWGYIK-EDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDM---- 221

Query: 237 AEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVM 296
                     GDSGGPL C+K+GLWYQ+G+VSWG+ CG+PNRPGVYTNIS +F WI+++M
Sbjct: 222 ----------GDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLM 271

Query: 297 SHS-TPRPNPSQLLLLLALLWA 317
           + S   +P+PS  LL   LLWA
Sbjct: 272 AQSGMSQPDPSWPLLFFPLLWA 293


>gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]
          Length = 321

 Score =  221 bits (564), Expect = 5e-58
 Identities = 135/318 (42%), Positives = 177/318 (55%), Gaps = 30/318 (9%)

Query: 3   ARGALLLALLLARAGLGKPGELGALQAGPGAARRPGGGGREEACGHREIHALVAGGVESA 62
           A GA  L LLLA  G+     L  LQ G G  +    GGR            + GG  + 
Sbjct: 2   ALGACGLLLLLAVPGVS----LRTLQPGCGRPQVSDAGGR------------IVGGHAAP 45

Query: 63  RGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELTSRPTPWNL 122
            G WPWQASLRLRR H CGGSLLS +WVL+AAHCF      S++ V LGEL    +P   
Sbjct: 46  AGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPH-- 103

Query: 123 RAYSSRYKVQDIIVNPDALGV--LRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPD 180
             +S+   V+ II++    G      DIAL+ L+  VT ++ I P+C+  ++ +F     
Sbjct: 104 --FST---VRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIR 158

Query: 181 CWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGAEDG 240
           CWVTGWG  +  G PLPPPY+LRE +V++++   C   +  P   S++   M CA    G
Sbjct: 159 CWVTGWGY-TREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGG-SILQPDMLCAR---G 213

Query: 241 SVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVMSHST 300
             D C+ DSGGPLVC  +G W Q GIVSWG  CG+PNRPGVYT +  Y +WIRR ++ S 
Sbjct: 214 PGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASG 273

Query: 301 PRPNPSQLLLLLALLWAP 318
              +    L LLA  + P
Sbjct: 274 GSESGYPRLPLLAGFFLP 291


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  213 bits (542), Expect = 2e-55
 Identities = 123/309 (39%), Positives = 173/309 (55%), Gaps = 31/309 (10%)

Query: 13  LARAGLGKPGELGA---------LQAGPGAARRPGGGGREEACGHREIHALVAGGVESAR 63
           +A+ G+  PG+LGA         L++G GA       G E  CG     A + GG  +  
Sbjct: 1   MAQKGVLGPGQLGAVAILLYLGLLRSGTGAE------GAEAPCGVAP-QARITGGSSAVA 53

Query: 64  GRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELTSRPTPWNLR 123
           G+WPWQ S+     H CGGSL+S +WVLSAAHCF   ++   + V+LG          L 
Sbjct: 54  GQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGA-------HQLD 106

Query: 124 AYSSRYKV---QDIIVNPDALGV-LRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRP 179
           +YS   KV   +DII +P  L    + DIALL+L+  +T++ YI+PIC+ ++  +F +  
Sbjct: 107 SYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGL 166

Query: 180 DCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFE---QPSSRSMIWDSMFCAG 236
            C VTGWG ++PS + L P   L++ +V +++   CN L+    +P     + + M CAG
Sbjct: 167 HCTVTGWGHVAPSVSLLTPK-PLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAG 225

Query: 237 AEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVM 296
             +G  D C+GDSGGPL C  +GLWY  GIVSWG  CG  NRPGVYT  S Y  WI+  +
Sbjct: 226 YVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKV 285

Query: 297 SHSTPRPNP 305
           +   PR  P
Sbjct: 286 TELQPRVVP 294


>gi|58218970 protease, serine, 36 [Homo sapiens]
          Length = 855

 Score =  202 bits (513), Expect = 4e-52
 Identities = 108/264 (40%), Positives = 149/264 (56%), Gaps = 10/264 (3%)

Query: 46  CGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYY--- 102
           CG  E  A + GG  +  G WPWQ SL     H CGGSL++  WVLSAAHCF  +     
Sbjct: 38  CGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEP 97

Query: 103 PSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAY 162
            +EW+V LG + S+  P  L    +R     ++    +   L  D+ALLRLAS  +    
Sbjct: 98  AAEWSVLLG-VHSQDGP--LDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPA 154

Query: 163 IQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQP 222
           + P+C+  ++  FVH   CW TGWG +  +  PLP P+ L+E ++ +L    C  L+ QP
Sbjct: 155 VWPVCLPRASHRFVHGTACWATGWGDVQEAD-PLPLPWVLQEVELRLLGEATCQCLYSQP 213

Query: 223 SSRSM---IWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRP 279
              ++   I   M CAG  +G  DTC+GDSGGPLVC++ G W+Q GI S+G  CG+ NRP
Sbjct: 214 GPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRP 273

Query: 280 GVYTNISVYFHWIRRVMSHSTPRP 303
           GV+T ++ Y  WIR  +  S P P
Sbjct: 274 GVFTAVATYEAWIREQVMGSEPGP 297



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 71/262 (27%), Positives = 111/262 (42%), Gaps = 30/262 (11%)

Query: 42  REEACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCF---- 97
           REE C      AL   G     G WPW+A + +     C G+L+S  WVL+ A CF    
Sbjct: 314 REENC----TIALPECGKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPN 369

Query: 98  QKHYYPSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSV 157
                P +       L SRP            +V  ++ + +A     +D+ALL+L + V
Sbjct: 370 SSDSPPRDLDAWRVLLPSRP---------RAERVARLVQHENASWDNASDLALLQLRTPV 420

Query: 158 TYNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNY 217
             +A  +P+C+      F+    C +  WG     G P   P  L EA+  +L    C+ 
Sbjct: 421 NLSAASRPVCLPHPEHYFLPGSRCRLARWG----RGEPALGPGALLEAE--LLGGWWCHC 474

Query: 218 LF-EQPSSRSMIWD---SMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDC 273
           L+  Q ++  +  D   ++  A  E   V +C  DS   L+C ++G W+  GI  +   C
Sbjct: 475 LYGRQGAAVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGC 534

Query: 274 GQPNRPGVYTNISVYFHWIRRV 295
               RP  +  +  +  WI  V
Sbjct: 535 ---LRPRAFFPLQTHGPWISHV 553



 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 59/214 (27%), Positives = 88/214 (41%), Gaps = 35/214 (16%)

Query: 66  WPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWT-----VQLGELTSRPTPW 120
           WPW A + +     C G LL+  WVL+A HC  +   P   T     V LG   +   P 
Sbjct: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLR---PGSTTVPYIEVYLGRAGASSLP- 656

Query: 121 NLRAYSSRYKVQDIIVN---PDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVH 177
                   ++V  ++++   P  LG LR  +ALL L+S V  +    PIC+  +      
Sbjct: 657 ------QGHQVSRLVISIRLPQHLG-LRPPLALLELSSRVEPSPSALPICLHPA--GIPP 707

Query: 178 RPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGA 237
              CWV GW          P       A V+IL    C+ L++      ++     C   
Sbjct: 708 GASCWVLGW--------KEPQDRVPVAAAVSILTQRICDCLYQ-----GILPPGTLCVLY 754

Query: 238 EDGSVDTCKGDSGGPLVCD-KDGLWYQVGIVSWG 270
            +G  + C+  S  PL+C   +G W  VG+   G
Sbjct: 755 AEGQENRCEMTSAPPLLCQMTEGSWILVGMAVQG 788


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  197 bits (502), Expect = 8e-51
 Identities = 105/258 (40%), Positives = 145/258 (56%), Gaps = 21/258 (8%)

Query: 45  ACGHREIHAL-VAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYP 103
           ACGHR  ++  + GG  S   +WPWQASL+ +  H CGGS+++  W+++AAHC    Y P
Sbjct: 206 ACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLP 265

Query: 104 SEWTVQLG--ELTSRPTPWNLR---AYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVT 158
             WT+Q+G   L   P P +L     Y S+YK       P  LG   NDIAL++LA  +T
Sbjct: 266 KSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYK-------PKRLG---NDIALMKLAGPLT 315

Query: 159 YNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYL 218
           +N  IQP+C+ +S  NF     CW +GWG          P  N   A V +++N  CN+ 
Sbjct: 316 FNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLN--HAAVPLISNKICNH- 372

Query: 219 FEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNR 278
             +     +I  SM CAG   G VD+C+GDSGGPLVC +  LW  VG  S+G+ C + N+
Sbjct: 373 --RDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNK 430

Query: 279 PGVYTNISVYFHWIRRVM 296
           PGVYT ++ +  WI   M
Sbjct: 431 PGVYTRVTSFLDWIHEQM 448


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  197 bits (500), Expect = 1e-50
 Identities = 103/242 (42%), Positives = 138/242 (57%), Gaps = 16/242 (6%)

Query: 55  VAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELT 114
           + GG E+  G WPWQ SLRL   H CGGSL++  W+L+AAHCF+ +  P +W    G  T
Sbjct: 187 ILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGIST 246

Query: 115 SRPTPWNLRAYSSRYKVQDIIV-NPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTF 173
           + P          R +V++I++ N        NDIAL+RL +SVT+   I  +C+ ++T 
Sbjct: 247 TFP--------KLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQ 298

Query: 174 NFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMF 233
           N       +VTGWG    +G  +P    LR+ QV I++N  CN      S    I   M 
Sbjct: 299 NIPPGSTAYVTGWGAQEYAGHTVP---ELRQGQVRIISNDVCN---APHSYNGAILSGML 352

Query: 234 CAGAEDGSVDTCKGDSGGPLVC-DKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWI 292
           CAG   G VD C+GDSGGPLV  D   LW+ VGIVSWG  CG P++PGVYT ++ Y  WI
Sbjct: 353 CAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWI 412

Query: 293 RR 294
           R+
Sbjct: 413 RQ 414


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  193 bits (491), Expect = 1e-49
 Identities = 103/263 (39%), Positives = 150/263 (57%), Gaps = 10/263 (3%)

Query: 40  GGREEACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQK 99
           G +  ACG   + + + GG +   G WPWQAS++ R  H CGGSL++ +WVL+AAHCF +
Sbjct: 22  GRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPR 81

Query: 100 HYYPSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPD-ALGVLRNDIALLRLASSVT 158
              P+E+ V+LG L    T  + R  S    V+ +++ PD +    R D+ALL+L   V 
Sbjct: 82  RALPAEYRVRLGALRLGST--SPRTLS--VPVRRVLLPPDYSEDGARGDLALLQLRRPVP 137

Query: 159 YNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYL 218
            +A +QP+C+            C VTGWG + P G PLP    L+  +V +L++  C+ L
Sbjct: 138 LSARVQPVCLPVPGARPPPGTPCRVTGWGSLRP-GVPLPEWRPLQGVRVPLLDSRTCDGL 196

Query: 219 F----EQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCG 274
           +    + P +  ++     CAG   G  D C+GDSGGPL C + G W  VG+VSWG  C 
Sbjct: 197 YHVGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCA 256

Query: 275 QPNRPGVYTNISVYFHWIRRVMS 297
            PNRPGVYT+++ Y  WI+  +S
Sbjct: 257 LPNRPGVYTSVATYSPWIQARVS 279


>gi|148806900 epidermis-specific serine protease-like protein [Homo
           sapiens]
          Length = 328

 Score =  193 bits (490), Expect = 2e-49
 Identities = 104/261 (39%), Positives = 146/261 (55%), Gaps = 17/261 (6%)

Query: 46  CGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSE 105
           CG     + V GG ++A GRWPWQ SL       CGGSL+S R +L+AAHC Q  +    
Sbjct: 19  CGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFS 78

Query: 106 WTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQP 165
           +TV LG +T   +   ++ Y S+     I+++P        D+ALL+L+S VT+ + I P
Sbjct: 79  YTVWLGSITVGDSRKRVKYYVSK-----IVIHPKYQDTTA-DVALLKLSSQVTFTSAILP 132

Query: 166 ICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYN--LREAQVTILNNTRCNYLFEQ-- 221
           IC+ S T      P CWVTGWG +  S       Y+  L+EA+V I++   C  L+    
Sbjct: 133 ICLPSVTKQLAIPPFCWVTGWGKVKESS---DRDYHSALQEAEVPIIDRQACEQLYNPIG 189

Query: 222 ---PSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNR 278
              P+   +I +   CAG      D+CKGDSGGPL C  DG+W Q G+VSWG++CG+ + 
Sbjct: 190 IFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECGK-SL 248

Query: 279 PGVYTNISVYFHWIRRVMSHS 299
           PGVYTN+  Y  WI   +S +
Sbjct: 249 PGVYTNVIYYQKWINATISRA 269


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  188 bits (478), Expect = 5e-48
 Identities = 100/259 (38%), Positives = 145/259 (55%), Gaps = 14/259 (5%)

Query: 45  ACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPS 104
           ACG   +   + GG ++  G WPWQ S++    H CGGSL++ +WVL+AAHCF+     S
Sbjct: 25  ACGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTAAHCFRNTSETS 84

Query: 105 EWTVQLG-ELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRN-DIALLRLASSVTYNAY 162
            + V LG     +P P  + A     +V+ +  NP   G   + D+AL+ L + V +  Y
Sbjct: 85  LYQVLLGARQLVQPGPHAMYA-----RVRQVESNPLYQGTASSADVALVELEAPVPFTNY 139

Query: 163 IQPICIESSTFNFVHRPDCWVTGWGLISPSGTPL-PPPYNLREAQVTILNNTRCNYLFEQ 221
           I P+C+   +  F    +CWVTGWG  SPS   L P P  L++  V I++  +CN L+ +
Sbjct: 140 ILPVCLPDPSVIFETGMNCWVTGWG--SPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSK 197

Query: 222 PSS----RSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPN 277
            +        I + M CAG E+G  D CKGDSGGPLVC     W Q G++SWG  C + N
Sbjct: 198 DTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQAGVISWGEGCARQN 257

Query: 278 RPGVYTNISVYFHWIRRVM 296
           RPGVY  ++ + +WI R++
Sbjct: 258 RPGVYIRVTAHHNWIHRII 276


>gi|11545839 protease, serine, 22 [Homo sapiens]
          Length = 317

 Score =  186 bits (471), Expect = 3e-47
 Identities = 96/258 (37%), Positives = 144/258 (55%), Gaps = 14/258 (5%)

Query: 45  ACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYY-P 103
           ACG  +    V GG +S    WPW  S++    H C GSLL+ RWV++AAHCF+ +   P
Sbjct: 40  ACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKP 99

Query: 104 SEWTVQLGELTSRPTPWNLRAYSSR-YKVQDIIVNPDALGVLRN----DIALLRLASSVT 158
             ++V LG        W L    SR  KV    V P  +   +     DIAL+RL  S+ 
Sbjct: 100 YLFSVLLGA-------WQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQ 152

Query: 159 YNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYL 218
           ++  + PIC+  ++ +      CW++GWG I   G PLP P  L++ +V I+++  C++L
Sbjct: 153 FSERVLPICLPDASIHLPPNTHCWISGWGSIQ-DGVPLPHPQTLQKLKVPIIDSEVCSHL 211

Query: 219 FEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNR 278
           + + + +  I + M CAG  +G  D C GDSGGPL+C  DG W   GI+SWG  C + NR
Sbjct: 212 YWRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNR 271

Query: 279 PGVYTNISVYFHWIRRVM 296
           PGVY ++S +  W+ +++
Sbjct: 272 PGVYISLSAHRSWVEKIV 289


>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
          Length = 416

 Score =  185 bits (469), Expect = 5e-47
 Identities = 100/254 (39%), Positives = 147/254 (57%), Gaps = 21/254 (8%)

Query: 46  CGHREIHALVAG-----GVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKH 100
           CG +  ++++ G     G  S  G WPWQAS++ + RH CG SL+S RW+LSAAHCF K 
Sbjct: 171 CGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKK 230

Query: 101 YYPSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPD-ALGVLRNDIALLRLASSVTY 159
               +WTV  G + ++P       Y +R KVQ+II + + +   L +DIAL++LA  V++
Sbjct: 231 NNSKDWTVNFGIVVNKP-------YMTR-KVQNIIFHENYSSPGLHDDIALVQLAEEVSF 282

Query: 160 NAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLF 219
             YI+ IC+  +        +  VTGWG +  +G+    P  L+E  + I++N  CN  +
Sbjct: 283 TEYIRKICLPEAKMKLSENDNVVVTGWGTLYMNGS---FPVILQEDFLKIIDNKICNASY 339

Query: 220 EQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVC-DKDGLWYQVGIVSWGMDCGQPNR 278
              +    + D+M CAG   G  D C+ DSGGPL   D   +W+ VGIVSWG  CG+ N+
Sbjct: 340 ---AYSGFVTDTMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNK 396

Query: 279 PGVYTNISVYFHWI 292
           PGVYT ++ Y +WI
Sbjct: 397 PGVYTRVTSYRNWI 410


>gi|239753545 PREDICTED: similar to hCG2041452 [Homo sapiens]
          Length = 410

 Score =  183 bits (465), Expect = 2e-46
 Identities = 108/288 (37%), Positives = 149/288 (51%), Gaps = 26/288 (9%)

Query: 16  AGLGKPGELGALQAGPGAARRPGGG---GRE--EACGHREIHALVAGGVESARGRWPWQA 70
           A  G PG      +  G A    G    GR+  +ACGHR    +  GG+ +   +WPWQ 
Sbjct: 121 ATAGPPGSWVTSASTVGEALESDGISDLGRQFSQACGHRVSRMI--GGLPAPNKKWPWQV 178

Query: 71  SLRLRRRHRCGGSLLSRRWVLSAAHCFQKH--YYPSEWTVQLGELTSRPTPWNLRAYSSR 128
           SL+    H CGGSL+ RRWVL+AAHC  +   +    W +             +  +   
Sbjct: 179 SLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWEGGRWLLA-----------GIGRWDQA 227

Query: 129 YKVQDIIVNPDAL--GVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPDCWVTGW 186
           +K  + I+ P       L +DIAL  LA SV Y+++IQP C+    F      +CWVTGW
Sbjct: 228 WKHLEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPACLPEKLFEVEAGTECWVTGW 287

Query: 187 GLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQP--SSRSMIWDSMFCAGAEDGSVDT 244
           G +S S +  P P  L+E ++ I+ + +C  + +    S   M+     C G  D   D 
Sbjct: 288 GQVSESVSG-PMPLVLQETELNIMRHEKCCEMLKNKNISKSKMVTRGTVC-GYNDQGKDA 345

Query: 245 CKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWI 292
           C+GDSGGPLVC+ +G W QVGIVSWG+ CG+   PGVYT +S Y  WI
Sbjct: 346 CQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPGVYTEVSFYKKWI 393


>gi|239748117 PREDICTED: hypothetical protein XP_002346556 [Homo
           sapiens]
          Length = 410

 Score =  183 bits (465), Expect = 2e-46
 Identities = 108/288 (37%), Positives = 149/288 (51%), Gaps = 26/288 (9%)

Query: 16  AGLGKPGELGALQAGPGAARRPGGG---GRE--EACGHREIHALVAGGVESARGRWPWQA 70
           A  G PG      +  G A    G    GR+  +ACGHR    +  GG+ +   +WPWQ 
Sbjct: 121 ATAGPPGSWVTSASTVGEALESDGISDLGRQFSQACGHRVSRMI--GGLPAPNKKWPWQV 178

Query: 71  SLRLRRRHRCGGSLLSRRWVLSAAHCFQKH--YYPSEWTVQLGELTSRPTPWNLRAYSSR 128
           SL+    H CGGSL+ RRWVL+AAHC  +   +    W +             +  +   
Sbjct: 179 SLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWEGGRWLLA-----------GIGRWDQA 227

Query: 129 YKVQDIIVNPDAL--GVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPDCWVTGW 186
           +K  + I+ P       L +DIAL  LA SV Y+++IQP C+    F      +CWVTGW
Sbjct: 228 WKHLEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPACLPEKLFEVEAGTECWVTGW 287

Query: 187 GLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQP--SSRSMIWDSMFCAGAEDGSVDT 244
           G +S S +  P P  L+E ++ I+ + +C  + +    S   M+     C G  D   D 
Sbjct: 288 GQVSESVSG-PMPLVLQETELNIMRHEKCCEMLKNKNISKSKMVTRGTVC-GYNDQGKDA 345

Query: 245 CKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWI 292
           C+GDSGGPLVC+ +G W QVGIVSWG+ CG+   PGVYT +S Y  WI
Sbjct: 346 CQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPGVYTEVSFYKKWI 393


>gi|239742016 PREDICTED: hypothetical protein XP_002342392 [Homo
           sapiens]
          Length = 410

 Score =  183 bits (465), Expect = 2e-46
 Identities = 108/288 (37%), Positives = 149/288 (51%), Gaps = 26/288 (9%)

Query: 16  AGLGKPGELGALQAGPGAARRPGGG---GRE--EACGHREIHALVAGGVESARGRWPWQA 70
           A  G PG      +  G A    G    GR+  +ACGHR    +  GG+ +   +WPWQ 
Sbjct: 121 ATAGPPGSWVTSASTVGEALESDGISDLGRQFSQACGHRVSRMI--GGLPAPNKKWPWQV 178

Query: 71  SLRLRRRHRCGGSLLSRRWVLSAAHCFQKH--YYPSEWTVQLGELTSRPTPWNLRAYSSR 128
           SL+    H CGGSL+ RRWVL+AAHC  +   +    W +             +  +   
Sbjct: 179 SLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWEGGRWLLA-----------GIGRWDQA 227

Query: 129 YKVQDIIVNPDAL--GVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPDCWVTGW 186
           +K  + I+ P       L +DIAL  LA SV Y+++IQP C+    F      +CWVTGW
Sbjct: 228 WKHLEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPACLPEKLFEVEAGTECWVTGW 287

Query: 187 GLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQP--SSRSMIWDSMFCAGAEDGSVDT 244
           G +S S +  P P  L+E ++ I+ + +C  + +    S   M+     C G  D   D 
Sbjct: 288 GQVSESVSG-PMPLVLQETELNIMRHEKCCEMLKNKNISKSKMVTRGTVC-GYNDQGKDA 345

Query: 245 CKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWI 292
           C+GDSGGPLVC+ +G W QVGIVSWG+ CG+   PGVYT +S Y  WI
Sbjct: 346 CQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPGVYTEVSFYKKWI 393


>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
           sapiens]
          Length = 432

 Score =  182 bits (463), Expect = 3e-46
 Identities = 95/251 (37%), Positives = 138/251 (54%), Gaps = 13/251 (5%)

Query: 45  ACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPS 104
           ACG       V GG E++   WPWQ S++  ++H CGGS+L   WVL+AAHCF+KH    
Sbjct: 190 ACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVF 249

Query: 105 EWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQ 164
            W V+ G          L ++ S    + II+  + +    NDIAL++L   +T++  ++
Sbjct: 250 NWKVRAGS-------DKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVR 302

Query: 165 PICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSS 224
           PIC+             W+ GWG    +G  +     L +A V ++++TRCN      + 
Sbjct: 303 PICLPFFDEELTPATPLWIIGWGFTKQNGGKMSD--ILLQASVQVIDSTRCN---ADDAY 357

Query: 225 RSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTN 284
           +  + + M CAG  +G VDTC+GDSGGPL+   D  W+ VGIVSWG  CG P+ PGVYT 
Sbjct: 358 QGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD-QWHVVGIVSWGYGCGGPSTPGVYTK 416

Query: 285 ISVYFHWIRRV 295
           +S Y +WI  V
Sbjct: 417 VSAYLNWIYNV 427


>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
           sapiens]
          Length = 437

 Score =  182 bits (463), Expect = 3e-46
 Identities = 95/251 (37%), Positives = 138/251 (54%), Gaps = 13/251 (5%)

Query: 45  ACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPS 104
           ACG       V GG E++   WPWQ S++  ++H CGGS+L   WVL+AAHCF+KH    
Sbjct: 195 ACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVF 254

Query: 105 EWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQ 164
            W V+ G          L ++ S    + II+  + +    NDIAL++L   +T++  ++
Sbjct: 255 NWKVRAGS-------DKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVR 307

Query: 165 PICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSS 224
           PIC+             W+ GWG    +G  +     L +A V ++++TRCN      + 
Sbjct: 308 PICLPFFDEELTPATPLWIIGWGFTKQNGGKMSD--ILLQASVQVIDSTRCN---ADDAY 362

Query: 225 RSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTN 284
           +  + + M CAG  +G VDTC+GDSGGPL+   D  W+ VGIVSWG  CG P+ PGVYT 
Sbjct: 363 QGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD-QWHVVGIVSWGYGCGGPSTPGVYTK 421

Query: 285 ISVYFHWIRRV 295
           +S Y +WI  V
Sbjct: 422 VSAYLNWIYNV 432


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  179 bits (455), Expect = 2e-45
 Identities = 98/268 (36%), Positives = 148/268 (55%), Gaps = 20/268 (7%)

Query: 36  RPGGGGREEACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAH 95
           R G       CG +   + + GG  S+ G WPWQASL++R RH CGG+L++ RWV++AAH
Sbjct: 558 RDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAH 617

Query: 96  CFQKHYYPSE--WTVQLGELTSRPTPWNLRAYSSR--YKVQDIIVNPDALGVLRN-DIAL 150
           CFQ+    S   WTV LG++      W    +     +KV  ++++P       + D+AL
Sbjct: 618 CFQEDSMASTVLWTVFLGKV------WQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVAL 671

Query: 151 LRLASSVTYNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTIL 210
           L+L   V  +A ++P+C+ + +  F     CW+TGWG +   G   P    L++  V ++
Sbjct: 672 LQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGG---PISNALQKVDVQLI 728

Query: 211 NNTRCNYLFEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDK-DGLWYQVGIVSW 269
               C+ ++     R  +   M CAG   G  D C+GDSGGPLVC    G W+  G+VSW
Sbjct: 729 PQDLCSEVY-----RYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSW 783

Query: 270 GMDCGQPNRPGVYTNISVYFHWIRRVMS 297
           G+ CG+PN  GVYT I+    WI++V++
Sbjct: 784 GLGCGRPNYFGVYTRITGVISWIQQVVT 811


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  175 bits (444), Expect = 4e-44
 Identities = 91/259 (35%), Positives = 142/259 (54%), Gaps = 20/259 (7%)

Query: 45  ACG---HREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHY 101
           ACG   +    + + GG  +  G WPWQ SL ++  H CGGS+++  W+++AAHC +K  
Sbjct: 280 ACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPL 339

Query: 102 Y-PSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRN-DIALLRLASSVTY 159
             P  WT   G L       +   Y + Y+V+ +I +P+     +N DIAL++L   +T+
Sbjct: 340 NNPWHWTAFAGILRQ-----SFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTF 394

Query: 160 NAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCN--Y 217
           N  ++P+C+ +          CW++GWG     G        L  A+V ++   RCN  Y
Sbjct: 395 NDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEV---LNAAKVLLIETQRCNSRY 451

Query: 218 LFEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPN 277
           +++     ++I  +M CAG   G+VD+C+GDSGGPLV  K+ +W+ +G  SWG  C +  
Sbjct: 452 VYD-----NLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAY 506

Query: 278 RPGVYTNISVYFHWIRRVM 296
           RPGVY N+ V+  WI R M
Sbjct: 507 RPGVYGNVMVFTDWIYRQM 525


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  175 bits (444), Expect = 4e-44
 Identities = 91/259 (35%), Positives = 142/259 (54%), Gaps = 20/259 (7%)

Query: 45  ACG---HREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHY 101
           ACG   +    + + GG  +  G WPWQ SL ++  H CGGS+++  W+++AAHC +K  
Sbjct: 243 ACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPL 302

Query: 102 Y-PSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRN-DIALLRLASSVTY 159
             P  WT   G L       +   Y + Y+V+ +I +P+     +N DIAL++L   +T+
Sbjct: 303 NNPWHWTAFAGILRQ-----SFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTF 357

Query: 160 NAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCN--Y 217
           N  ++P+C+ +          CW++GWG     G        L  A+V ++   RCN  Y
Sbjct: 358 NDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEV---LNAAKVLLIETQRCNSRY 414

Query: 218 LFEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPN 277
           +++     ++I  +M CAG   G+VD+C+GDSGGPLV  K+ +W+ +G  SWG  C +  
Sbjct: 415 VYD-----NLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAY 469

Query: 278 RPGVYTNISVYFHWIRRVM 296
           RPGVY N+ V+  WI R M
Sbjct: 470 RPGVYGNVMVFTDWIYRQM 488


>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score =  174 bits (440), Expect = 1e-43
 Identities = 97/261 (37%), Positives = 140/261 (53%), Gaps = 26/261 (9%)

Query: 44   EACGHR----EIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHC-FQ 98
            ++CG +    +I   + GG  +  G WPW   L    R  CG SL+S  W++SAAHC + 
Sbjct: 770  KSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYG 829

Query: 99   KHYYPSEWTVQLG-----ELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLR-NDIALLR 152
            ++  PS+WT  LG      LTS  T   L        + +I++NP      + NDIA++ 
Sbjct: 830  RNLEPSKWTAILGLHMKSNLTSPQTVPRL--------IDEIVINPHYNRRRKDNDIAMMH 881

Query: 153  LASSVTYNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNN 212
            L   V Y  YIQPIC+      F    +C + GWG +   GT       L+EA V +L+N
Sbjct: 882  LEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANI---LQEADVPLLSN 938

Query: 213  TRCNYLFEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMD 272
             RC    +Q      I ++M CAG E+G +D+C+GDSGGPL+C ++  W+  G+ S+G  
Sbjct: 939  ERC----QQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYK 994

Query: 273  CGQPNRPGVYTNISVYFHWIR 293
            C  PNRPGVY  +S +  WI+
Sbjct: 995  CALPNRPGVYARVSRFTEWIQ 1015


>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
          Length = 423

 Score =  172 bits (435), Expect = 5e-43
 Identities = 95/253 (37%), Positives = 137/253 (54%), Gaps = 19/253 (7%)

Query: 46  CGHREIHAL-----VAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKH 100
           CG R    L     + GG E   G WPWQASL+    HRCG +L++  W++SAAHCF  +
Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237

Query: 101 YYPSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYN 160
             P+ WT   G +T +P+   ++    R  V +   +P        DI+L  L+S V Y 
Sbjct: 238 KNPARWTASFG-VTIKPS--KMKRGLRRIIVHEKYKHPSH----DYDISLAELSSPVPYT 290

Query: 161 AYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFE 220
             +  +C+  +++ F      +VTG+G +   G       +LR+AQVT+++ T CN   E
Sbjct: 291 NAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGY---SQNHLRQAQVTLIDATTCN---E 344

Query: 221 QPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLV-CDKDGLWYQVGIVSWGMDCGQPNRP 279
             +    I   M CAG+ +G  D C+GDSGGPLV  D   +WY  GIVSWG +C +PN+P
Sbjct: 345 PQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKP 404

Query: 280 GVYTNISVYFHWI 292
           GVYT ++    WI
Sbjct: 405 GVYTRVTALRDWI 417


>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
          Length = 423

 Score =  172 bits (435), Expect = 5e-43
 Identities = 95/253 (37%), Positives = 137/253 (54%), Gaps = 19/253 (7%)

Query: 46  CGHREIHAL-----VAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKH 100
           CG R    L     + GG E   G WPWQASL+    HRCG +L++  W++SAAHCF  +
Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237

Query: 101 YYPSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYN 160
             P+ WT   G +T +P+   ++    R  V +   +P        DI+L  L+S V Y 
Sbjct: 238 KNPARWTASFG-VTIKPS--KMKRGLRRIIVHEKYKHPSH----DYDISLAELSSPVPYT 290

Query: 161 AYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFE 220
             +  +C+  +++ F      +VTG+G +   G       +LR+AQVT+++ T CN   E
Sbjct: 291 NAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGY---SQNHLRQAQVTLIDATTCN---E 344

Query: 221 QPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLV-CDKDGLWYQVGIVSWGMDCGQPNRP 279
             +    I   M CAG+ +G  D C+GDSGGPLV  D   +WY  GIVSWG +C +PN+P
Sbjct: 345 PQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKP 404

Query: 280 GVYTNISVYFHWI 292
           GVYT ++    WI
Sbjct: 405 GVYTRVTALRDWI 417


>gi|68508970 tryptase beta 2 precursor [Homo sapiens]
          Length = 275

 Score =  171 bits (434), Expect = 6e-43
 Identities = 94/246 (38%), Positives = 133/246 (54%), Gaps = 17/246 (6%)

Query: 55  VAGGVESARGRWPWQASLRLRRR---HRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLG 111
           + GG E+ R +WPWQ SLR+R R   H CGGSL+  +WVL+AAHC             L 
Sbjct: 31  IVGGQEAPRSKWPWQVSLRVRDRYWMHFCGGSLIHPQWVLTAAHCVGPD------VKDLA 84

Query: 112 ELTSRPTPWNLRAYSSRYKVQDIIVNPDALGV-LRNDIALLRLASSVTYNAYIQPICIES 170
            L  +    +L        V  IIV+P      +  DIALL L   V  ++++  + +  
Sbjct: 85  ALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPP 144

Query: 171 STFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRS---- 226
           ++  F     CWVTGWG +  +   LPPP+ L++ +V I+ N  C+  +   +       
Sbjct: 145 ASETFPPGMPCWVTGWGDVD-NDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVR 203

Query: 227 MIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNIS 286
           ++ D M CAG  +   D+C+GDSGGPLVC  +G W Q G+VSWG  C QPNRPG+YT ++
Sbjct: 204 IVRDDMLCAG--NTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVT 261

Query: 287 VYFHWI 292
            Y  WI
Sbjct: 262 YYLDWI 267


>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
          Length = 438

 Score =  171 bits (434), Expect = 6e-43
 Identities = 92/241 (38%), Positives = 134/241 (55%), Gaps = 16/241 (6%)

Query: 54  LVAGGVESARGRWPWQASLRL-RRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGE 112
           +V G   +  G WPWQASL+L    H+CG SL+S  W+L+AAHCF K+  P++W    G 
Sbjct: 206 IVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQWIATFGA 265

Query: 113 LTSRPTPWNLRAYSSRYKVQDIIVNPDA-LGVLRNDIALLRLASSVTYNAYIQPICIESS 171
             + P        + +  V+ II++ +       NDIAL++L++ V ++  +Q +C+  S
Sbjct: 266 TITPP--------AVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDS 317

Query: 172 TFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDS 231
           +     +   +VTG+G I   G   P    LR+A+V  ++   CN    +     +I   
Sbjct: 318 SIKLPPKTSVFVTGFGSIVDDG---PIQNTLRQARVETISTDVCN---RKDVYDGLITPG 371

Query: 232 MFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHW 291
           M CAG  +G +D CKGDSGGPLV D   +WY VGIVSWG  C  P +PGVYT ++ Y  W
Sbjct: 372 MLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDW 431

Query: 292 I 292
           I
Sbjct: 432 I 432


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  171 bits (433), Expect = 8e-43
 Identities = 95/251 (37%), Positives = 133/251 (52%), Gaps = 17/251 (6%)

Query: 46  CGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCF--QKHYYP 103
           CG R +   + GG  ++  +WPWQ SL     H CGG+L+  +WVL+AAHCF   +    
Sbjct: 317 CGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVL 376

Query: 104 SEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRN-DIALLRLASSVTYNAY 162
             W V  G  TS     NL        + +II+N +      + DIAL+RL+  +T +A+
Sbjct: 377 EGWKVYAG--TS-----NLHQLPEAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAH 429

Query: 163 IQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCN-YLFEQ 221
           I P C+      F     CW+TG+G    +     P   LRE QV +++  +CN YL   
Sbjct: 430 IHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSP--FLREVQVNLIDFKKCNDYLVYD 487

Query: 222 PSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGV 281
               S +   M CAG   G  D+C+GDSGGPLVC+++  WY  G+ SWG  CGQ N+PGV
Sbjct: 488 ----SYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGV 543

Query: 282 YTNISVYFHWI 292
           YT ++    WI
Sbjct: 544 YTKVTEVLPWI 554


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  171 bits (432), Expect = 1e-42
 Identities = 88/246 (35%), Positives = 134/246 (54%), Gaps = 23/246 (9%)

Query: 55  VAGGVESARGRWPWQASLRLR---RRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLG 111
           + GG  S+ G WPWQ SL+++   +RH CGGSL+  +WVL+AAHCF        W +  G
Sbjct: 391 IVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSG 450

Query: 112 ELT----SRPTPWNLRAYSSRYKVQDIIVNPD-ALGVLRNDIALLRLASSVTYNAYIQPI 166
            L     ++ TP++        ++++II++ +  +    +DIAL++L + + Y  + +PI
Sbjct: 451 ILNLSDITKDTPFS--------QIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPI 502

Query: 167 CIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRS 226
           C+ S         +CWVTGWG     G        L++  + ++ N  C   ++      
Sbjct: 503 CLPSKGDTSTIYTNCWVTGWGFSKEKGEI---QNILQKVNIPLVTNEECQKRYQDYK--- 556

Query: 227 MIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNIS 286
            I   M CAG ++G  D CKGDSGGPLVC  +G+W  VGI SWG  C +  +PGVYT ++
Sbjct: 557 -ITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVA 615

Query: 287 VYFHWI 292
            Y  WI
Sbjct: 616 EYMDWI 621


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  169 bits (428), Expect = 3e-42
 Identities = 94/247 (38%), Positives = 128/247 (51%), Gaps = 15/247 (6%)

Query: 50  EIHALVAGGVESARGRWPWQASLRLR---RRHRCGGSLLSRRWVLSAAHCFQKHYYPSEW 106
           +I   + GG  S RG WPWQ +L      +RH CGGS++  +W+L+AAHCF     P   
Sbjct: 383 KIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKIL 442

Query: 107 TVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPD-ALGVLRNDIALLRLASSVTYNAYIQP 165
            V  G L        ++  +S + VQ+II++    +     DIALL+L ++V Y    +P
Sbjct: 443 RVYSGILNQS----EIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRP 498

Query: 166 ICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSR 225
           IC+ S     V   DCWVTGWG              L++A++ ++ N  C   +      
Sbjct: 499 ICLPSKGDRNVIYTDCWVTGWGYRKLRDKI---QNTLQKAKIPLVTNEECQKRYRGHK-- 553

Query: 226 SMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNI 285
             I   M CAG  +G  D CKGDSGGPL C  + +W+ VGI SWG  C Q  RPGVYTN+
Sbjct: 554 --ITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNV 611

Query: 286 SVYFHWI 292
             Y  WI
Sbjct: 612 VEYVDWI 618


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.462 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,699,967
Number of Sequences: 37866
Number of extensions: 739047
Number of successful extensions: 3153
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 179
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 2487
Number of HSP's gapped (non-prelim): 252
length of query: 318
length of database: 18,247,518
effective HSP length: 102
effective length of query: 216
effective length of database: 14,385,186
effective search space: 3107200176
effective search space used: 3107200176
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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