BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|205360905 testis-specific serine protease 1 [Homo sapiens] (318 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|205360905 testis-specific serine protease 1 [Homo sapiens] 673 0.0 gi|21614531 testisin isoform 2 [Homo sapiens] 336 1e-92 gi|5803197 testisin isoform 1 [Homo sapiens] 336 2e-92 gi|21614533 testisin isoform 3 [Homo sapiens] 314 6e-86 gi|156938340 transmembrane tryptase preproprotein [Homo sapiens] 221 5e-58 gi|4506153 prostasin preproprotein [Homo sapiens] 213 2e-55 gi|58218970 protease, serine, 36 [Homo sapiens] 202 4e-52 gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap... 197 8e-51 gi|4758508 transmembrane protease, serine 11D [Homo sapiens] 197 1e-50 gi|117956391 protease, serine, 33 [Homo sapiens] 193 1e-49 gi|148806900 epidermis-specific serine protease-like protein [Ho... 193 2e-49 gi|13994276 marapsin [Homo sapiens] 188 5e-48 gi|11545839 protease, serine, 22 [Homo sapiens] 186 3e-47 gi|187761337 transmembrane protease, serine 11B [Homo sapiens] 185 5e-47 gi|239753545 PREDICTED: similar to hCG2041452 [Homo sapiens] 183 2e-46 gi|239748117 PREDICTED: hypothetical protein XP_002346556 [Homo ... 183 2e-46 gi|239742016 PREDICTED: hypothetical protein XP_002342392 [Homo ... 183 2e-46 gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa... 182 3e-46 gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap... 182 3e-46 gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 179 2e-45 gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa... 175 4e-44 gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa... 175 4e-44 gi|223942069 enterokinase precursor [Homo sapiens] 174 1e-43 gi|40254871 transmembrane protease, serine 11E [Homo sapiens] 172 5e-43 gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens] 172 5e-43 gi|68508970 tryptase beta 2 precursor [Homo sapiens] 171 6e-43 gi|194018492 transmembrane protease, serine 11F [Homo sapiens] 171 6e-43 gi|116256363 transmembrane protease, serine 13 [Homo sapiens] 171 8e-43 gi|78191798 plasma kallikrein B1 precursor [Homo sapiens] 171 1e-42 gi|4503627 coagulation factor XI precursor [Homo sapiens] 169 3e-42 >gi|205360905 testis-specific serine protease 1 [Homo sapiens] Length = 318 Score = 673 bits (1736), Expect = 0.0 Identities = 318/318 (100%), Positives = 318/318 (100%) Query: 1 MGARGALLLALLLARAGLGKPGELGALQAGPGAARRPGGGGREEACGHREIHALVAGGVE 60 MGARGALLLALLLARAGLGKPGELGALQAGPGAARRPGGGGREEACGHREIHALVAGGVE Sbjct: 1 MGARGALLLALLLARAGLGKPGELGALQAGPGAARRPGGGGREEACGHREIHALVAGGVE 60 Query: 61 SARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELTSRPTPW 120 SARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELTSRPTPW Sbjct: 61 SARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELTSRPTPW 120 Query: 121 NLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPD 180 NLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPD Sbjct: 121 NLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPD 180 Query: 181 CWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGAEDG 240 CWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGAEDG Sbjct: 181 CWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGAEDG 240 Query: 241 SVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVMSHST 300 SVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVMSHST Sbjct: 241 SVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVMSHST 300 Query: 301 PRPNPSQLLLLLALLWAP 318 PRPNPSQLLLLLALLWAP Sbjct: 301 PRPNPSQLLLLLALLWAP 318 >gi|21614531 testisin isoform 2 [Homo sapiens] Length = 312 Score = 336 bits (862), Expect = 1e-92 Identities = 172/320 (53%), Positives = 217/320 (67%), Gaps = 18/320 (5%) Query: 1 MGARGALLLALLLARAGLGKP-GELGALQAGPGAARRPGGGGREEACGHREIHALVAGGV 59 MGARGALLLALLLARAGL KP + A +GP CG R I + + GG Sbjct: 1 MGARGALLLALLLARAGLRKPESQEAAPLSGP--------------CGRRVITSRIVGGE 46 Query: 60 ESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYY-PSEWTVQLGELTSRPT 118 ++ GRWPWQ SLRL H CG SLLS RW L+AAHCF+ PS W VQ G+LTS P+ Sbjct: 47 DAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFGQLTSMPS 106 Query: 119 PWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHR 178 W+L+AY +RY V +I ++P LG DIAL++L++ VTY +IQPIC+++STF F +R Sbjct: 107 FWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENR 166 Query: 179 PDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGAE 238 DCWVTGWG I LP P+ L+E QV I+NN+ CN+LF + S R I+ M CAG Sbjct: 167 TDCWVTGWGYIKEDEA-LPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNA 225 Query: 239 DGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVMSH 298 G D C GDSGGPL C+K+GLWYQ+G+VSWG+ CG+PNRPGVYTNIS +F WI+++M+ Sbjct: 226 QGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQ 285 Query: 299 S-TPRPNPSQLLLLLALLWA 317 S +P+PS LL LLWA Sbjct: 286 SGMSQPDPSWPLLFFPLLWA 305 >gi|5803197 testisin isoform 1 [Homo sapiens] Length = 314 Score = 336 bits (861), Expect = 2e-92 Identities = 172/322 (53%), Positives = 218/322 (67%), Gaps = 20/322 (6%) Query: 1 MGARGALLLALLLARAGLGKP-GELGALQAGPGAARRPGGGGREEACGHREIHALVAGGV 59 MGARGALLLALLLARAGL KP + A +GP CG R I + + GG Sbjct: 1 MGARGALLLALLLARAGLRKPESQEAAPLSGP--------------CGRRVITSRIVGGE 46 Query: 60 ESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYY---PSEWTVQLGELTSR 116 ++ GRWPWQ SLRL H CG SLLS RW L+AAHCF+ + PS W VQ G+LTS Sbjct: 47 DAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWMVQFGQLTSM 106 Query: 117 PTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFV 176 P+ W+L+AY +RY V +I ++P LG DIAL++L++ VTY +IQPIC+++STF F Sbjct: 107 PSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFE 166 Query: 177 HRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAG 236 +R DCWVTGWG I LP P+ L+E QV I+NN+ CN+LF + S R I+ M CAG Sbjct: 167 NRTDCWVTGWGYIKEDEA-LPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAG 225 Query: 237 AEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVM 296 G D C GDSGGPL C+K+GLWYQ+G+VSWG+ CG+PNRPGVYTNIS +F WI+++M Sbjct: 226 NAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLM 285 Query: 297 SHS-TPRPNPSQLLLLLALLWA 317 + S +P+PS LL LLWA Sbjct: 286 AQSGMSQPDPSWPLLFFPLLWA 307 >gi|21614533 testisin isoform 3 [Homo sapiens] Length = 300 Score = 314 bits (805), Expect = 6e-86 Identities = 166/322 (51%), Positives = 212/322 (65%), Gaps = 34/322 (10%) Query: 1 MGARGALLLALLLARAGLGKP-GELGALQAGPGAARRPGGGGREEACGHREIHALVAGGV 59 MGARGALLLALLLARAGL KP + A +GP CG R I + + GG Sbjct: 1 MGARGALLLALLLARAGLRKPESQEAAPLSGP--------------CGRRVITSRIVGGE 46 Query: 60 ESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYY---PSEWTVQLGELTSR 116 ++ GRWPWQ SLRL H CG SLLS RW L+AAHCF+ + PS W VQ G+LTS Sbjct: 47 DAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWMVQFGQLTSM 106 Query: 117 PTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFV 176 P+ W+L+AY +RY V +I ++P LG DIAL++L++ VTY +IQPIC+++STF F Sbjct: 107 PSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFE 166 Query: 177 HRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAG 236 +R DCWVTGWG I LP P+ L+E QV I+NN+ CN+LF + S R I+ M Sbjct: 167 NRTDCWVTGWGYIK-EDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDM---- 221 Query: 237 AEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVM 296 GDSGGPL C+K+GLWYQ+G+VSWG+ CG+PNRPGVYTNIS +F WI+++M Sbjct: 222 ----------GDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLM 271 Query: 297 SHS-TPRPNPSQLLLLLALLWA 317 + S +P+PS LL LLWA Sbjct: 272 AQSGMSQPDPSWPLLFFPLLWA 293 >gi|156938340 transmembrane tryptase preproprotein [Homo sapiens] Length = 321 Score = 221 bits (564), Expect = 5e-58 Identities = 135/318 (42%), Positives = 177/318 (55%), Gaps = 30/318 (9%) Query: 3 ARGALLLALLLARAGLGKPGELGALQAGPGAARRPGGGGREEACGHREIHALVAGGVESA 62 A GA L LLLA G+ L LQ G G + GGR + GG + Sbjct: 2 ALGACGLLLLLAVPGVS----LRTLQPGCGRPQVSDAGGR------------IVGGHAAP 45 Query: 63 RGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELTSRPTPWNL 122 G WPWQASLRLRR H CGGSLLS +WVL+AAHCF S++ V LGEL +P Sbjct: 46 AGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPH-- 103 Query: 123 RAYSSRYKVQDIIVNPDALGV--LRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPD 180 +S+ V+ II++ G DIAL+ L+ VT ++ I P+C+ ++ +F Sbjct: 104 --FST---VRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIR 158 Query: 181 CWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGAEDG 240 CWVTGWG + G PLPPPY+LRE +V++++ C + P S++ M CA G Sbjct: 159 CWVTGWGY-TREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGG-SILQPDMLCAR---G 213 Query: 241 SVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVMSHST 300 D C+ DSGGPLVC +G W Q GIVSWG CG+PNRPGVYT + Y +WIRR ++ S Sbjct: 214 PGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASG 273 Query: 301 PRPNPSQLLLLLALLWAP 318 + L LLA + P Sbjct: 274 GSESGYPRLPLLAGFFLP 291 >gi|4506153 prostasin preproprotein [Homo sapiens] Length = 343 Score = 213 bits (542), Expect = 2e-55 Identities = 123/309 (39%), Positives = 173/309 (55%), Gaps = 31/309 (10%) Query: 13 LARAGLGKPGELGA---------LQAGPGAARRPGGGGREEACGHREIHALVAGGVESAR 63 +A+ G+ PG+LGA L++G GA G E CG A + GG + Sbjct: 1 MAQKGVLGPGQLGAVAILLYLGLLRSGTGAE------GAEAPCGVAP-QARITGGSSAVA 53 Query: 64 GRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELTSRPTPWNLR 123 G+WPWQ S+ H CGGSL+S +WVLSAAHCF ++ + V+LG L Sbjct: 54 GQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGA-------HQLD 106 Query: 124 AYSSRYKV---QDIIVNPDALGV-LRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRP 179 +YS KV +DII +P L + DIALL+L+ +T++ YI+PIC+ ++ +F + Sbjct: 107 SYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGL 166 Query: 180 DCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFE---QPSSRSMIWDSMFCAG 236 C VTGWG ++PS + L P L++ +V +++ CN L+ +P + + M CAG Sbjct: 167 HCTVTGWGHVAPSVSLLTPK-PLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAG 225 Query: 237 AEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVM 296 +G D C+GDSGGPL C +GLWY GIVSWG CG NRPGVYT S Y WI+ + Sbjct: 226 YVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKV 285 Query: 297 SHSTPRPNP 305 + PR P Sbjct: 286 TELQPRVVP 294 >gi|58218970 protease, serine, 36 [Homo sapiens] Length = 855 Score = 202 bits (513), Expect = 4e-52 Identities = 108/264 (40%), Positives = 149/264 (56%), Gaps = 10/264 (3%) Query: 46 CGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYY--- 102 CG E A + GG + G WPWQ SL H CGGSL++ WVLSAAHCF + Sbjct: 38 CGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEP 97 Query: 103 PSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAY 162 +EW+V LG + S+ P L +R ++ + L D+ALLRLAS + Sbjct: 98 AAEWSVLLG-VHSQDGP--LDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPA 154 Query: 163 IQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQP 222 + P+C+ ++ FVH CW TGWG + + PLP P+ L+E ++ +L C L+ QP Sbjct: 155 VWPVCLPRASHRFVHGTACWATGWGDVQEAD-PLPLPWVLQEVELRLLGEATCQCLYSQP 213 Query: 223 SSRSM---IWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRP 279 ++ I M CAG +G DTC+GDSGGPLVC++ G W+Q GI S+G CG+ NRP Sbjct: 214 GPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRP 273 Query: 280 GVYTNISVYFHWIRRVMSHSTPRP 303 GV+T ++ Y WIR + S P P Sbjct: 274 GVFTAVATYEAWIREQVMGSEPGP 297 Score = 77.4 bits (189), Expect = 2e-14 Identities = 71/262 (27%), Positives = 111/262 (42%), Gaps = 30/262 (11%) Query: 42 REEACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCF---- 97 REE C AL G G WPW+A + + C G+L+S WVL+ A CF Sbjct: 314 REENC----TIALPECGKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPN 369 Query: 98 QKHYYPSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSV 157 P + L SRP +V ++ + +A +D+ALL+L + V Sbjct: 370 SSDSPPRDLDAWRVLLPSRP---------RAERVARLVQHENASWDNASDLALLQLRTPV 420 Query: 158 TYNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNY 217 +A +P+C+ F+ C + WG G P P L EA+ +L C+ Sbjct: 421 NLSAASRPVCLPHPEHYFLPGSRCRLARWG----RGEPALGPGALLEAE--LLGGWWCHC 474 Query: 218 LF-EQPSSRSMIWD---SMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDC 273 L+ Q ++ + D ++ A E V +C DS L+C ++G W+ GI + C Sbjct: 475 LYGRQGAAVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGC 534 Query: 274 GQPNRPGVYTNISVYFHWIRRV 295 RP + + + WI V Sbjct: 535 ---LRPRAFFPLQTHGPWISHV 553 Score = 64.3 bits (155), Expect = 1e-10 Identities = 59/214 (27%), Positives = 88/214 (41%), Gaps = 35/214 (16%) Query: 66 WPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWT-----VQLGELTSRPTPW 120 WPW A + + C G LL+ WVL+A HC + P T V LG + P Sbjct: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLR---PGSTTVPYIEVYLGRAGASSLP- 656 Query: 121 NLRAYSSRYKVQDIIVN---PDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVH 177 ++V ++++ P LG LR +ALL L+S V + PIC+ + Sbjct: 657 ------QGHQVSRLVISIRLPQHLG-LRPPLALLELSSRVEPSPSALPICLHPA--GIPP 707 Query: 178 RPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGA 237 CWV GW P A V+IL C+ L++ ++ C Sbjct: 708 GASCWVLGW--------KEPQDRVPVAAAVSILTQRICDCLYQ-----GILPPGTLCVLY 754 Query: 238 EDGSVDTCKGDSGGPLVCD-KDGLWYQVGIVSWG 270 +G + C+ S PL+C +G W VG+ G Sbjct: 755 AEGQENRCEMTSAPPLLCQMTEGSWILVGMAVQG 788 >gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sapiens] Length = 454 Score = 197 bits (502), Expect = 8e-51 Identities = 105/258 (40%), Positives = 145/258 (56%), Gaps = 21/258 (8%) Query: 45 ACGHREIHAL-VAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYP 103 ACGHR ++ + GG S +WPWQASL+ + H CGGS+++ W+++AAHC Y P Sbjct: 206 ACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLP 265 Query: 104 SEWTVQLG--ELTSRPTPWNLR---AYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVT 158 WT+Q+G L P P +L Y S+YK P LG NDIAL++LA +T Sbjct: 266 KSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYK-------PKRLG---NDIALMKLAGPLT 315 Query: 159 YNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYL 218 +N IQP+C+ +S NF CW +GWG P N A V +++N CN+ Sbjct: 316 FNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLN--HAAVPLISNKICNH- 372 Query: 219 FEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNR 278 + +I SM CAG G VD+C+GDSGGPLVC + LW VG S+G+ C + N+ Sbjct: 373 --RDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNK 430 Query: 279 PGVYTNISVYFHWIRRVM 296 PGVYT ++ + WI M Sbjct: 431 PGVYTRVTSFLDWIHEQM 448 >gi|4758508 transmembrane protease, serine 11D [Homo sapiens] Length = 418 Score = 197 bits (500), Expect = 1e-50 Identities = 103/242 (42%), Positives = 138/242 (57%), Gaps = 16/242 (6%) Query: 55 VAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELT 114 + GG E+ G WPWQ SLRL H CGGSL++ W+L+AAHCF+ + P +W G T Sbjct: 187 ILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGIST 246 Query: 115 SRPTPWNLRAYSSRYKVQDIIV-NPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTF 173 + P R +V++I++ N NDIAL+RL +SVT+ I +C+ ++T Sbjct: 247 TFP--------KLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQ 298 Query: 174 NFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMF 233 N +VTGWG +G +P LR+ QV I++N CN S I M Sbjct: 299 NIPPGSTAYVTGWGAQEYAGHTVP---ELRQGQVRIISNDVCN---APHSYNGAILSGML 352 Query: 234 CAGAEDGSVDTCKGDSGGPLVC-DKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWI 292 CAG G VD C+GDSGGPLV D LW+ VGIVSWG CG P++PGVYT ++ Y WI Sbjct: 353 CAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWI 412 Query: 293 RR 294 R+ Sbjct: 413 RQ 414 >gi|117956391 protease, serine, 33 [Homo sapiens] Length = 280 Score = 193 bits (491), Expect = 1e-49 Identities = 103/263 (39%), Positives = 150/263 (57%), Gaps = 10/263 (3%) Query: 40 GGREEACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQK 99 G + ACG + + + GG + G WPWQAS++ R H CGGSL++ +WVL+AAHCF + Sbjct: 22 GRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPR 81 Query: 100 HYYPSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPD-ALGVLRNDIALLRLASSVT 158 P+E+ V+LG L T + R S V+ +++ PD + R D+ALL+L V Sbjct: 82 RALPAEYRVRLGALRLGST--SPRTLS--VPVRRVLLPPDYSEDGARGDLALLQLRRPVP 137 Query: 159 YNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYL 218 +A +QP+C+ C VTGWG + P G PLP L+ +V +L++ C+ L Sbjct: 138 LSARVQPVCLPVPGARPPPGTPCRVTGWGSLRP-GVPLPEWRPLQGVRVPLLDSRTCDGL 196 Query: 219 F----EQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCG 274 + + P + ++ CAG G D C+GDSGGPL C + G W VG+VSWG C Sbjct: 197 YHVGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCA 256 Query: 275 QPNRPGVYTNISVYFHWIRRVMS 297 PNRPGVYT+++ Y WI+ +S Sbjct: 257 LPNRPGVYTSVATYSPWIQARVS 279 >gi|148806900 epidermis-specific serine protease-like protein [Homo sapiens] Length = 328 Score = 193 bits (490), Expect = 2e-49 Identities = 104/261 (39%), Positives = 146/261 (55%), Gaps = 17/261 (6%) Query: 46 CGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSE 105 CG + V GG ++A GRWPWQ SL CGGSL+S R +L+AAHC Q + Sbjct: 19 CGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFS 78 Query: 106 WTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQP 165 +TV LG +T + ++ Y S+ I+++P D+ALL+L+S VT+ + I P Sbjct: 79 YTVWLGSITVGDSRKRVKYYVSK-----IVIHPKYQDTTA-DVALLKLSSQVTFTSAILP 132 Query: 166 ICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYN--LREAQVTILNNTRCNYLFEQ-- 221 IC+ S T P CWVTGWG + S Y+ L+EA+V I++ C L+ Sbjct: 133 ICLPSVTKQLAIPPFCWVTGWGKVKESS---DRDYHSALQEAEVPIIDRQACEQLYNPIG 189 Query: 222 ---PSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNR 278 P+ +I + CAG D+CKGDSGGPL C DG+W Q G+VSWG++CG+ + Sbjct: 190 IFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECGK-SL 248 Query: 279 PGVYTNISVYFHWIRRVMSHS 299 PGVYTN+ Y WI +S + Sbjct: 249 PGVYTNVIYYQKWINATISRA 269 >gi|13994276 marapsin [Homo sapiens] Length = 290 Score = 188 bits (478), Expect = 5e-48 Identities = 100/259 (38%), Positives = 145/259 (55%), Gaps = 14/259 (5%) Query: 45 ACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPS 104 ACG + + GG ++ G WPWQ S++ H CGGSL++ +WVL+AAHCF+ S Sbjct: 25 ACGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTAAHCFRNTSETS 84 Query: 105 EWTVQLG-ELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRN-DIALLRLASSVTYNAY 162 + V LG +P P + A +V+ + NP G + D+AL+ L + V + Y Sbjct: 85 LYQVLLGARQLVQPGPHAMYA-----RVRQVESNPLYQGTASSADVALVELEAPVPFTNY 139 Query: 163 IQPICIESSTFNFVHRPDCWVTGWGLISPSGTPL-PPPYNLREAQVTILNNTRCNYLFEQ 221 I P+C+ + F +CWVTGWG SPS L P P L++ V I++ +CN L+ + Sbjct: 140 ILPVCLPDPSVIFETGMNCWVTGWG--SPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSK 197 Query: 222 PSS----RSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPN 277 + I + M CAG E+G D CKGDSGGPLVC W Q G++SWG C + N Sbjct: 198 DTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQAGVISWGEGCARQN 257 Query: 278 RPGVYTNISVYFHWIRRVM 296 RPGVY ++ + +WI R++ Sbjct: 258 RPGVYIRVTAHHNWIHRII 276 >gi|11545839 protease, serine, 22 [Homo sapiens] Length = 317 Score = 186 bits (471), Expect = 3e-47 Identities = 96/258 (37%), Positives = 144/258 (55%), Gaps = 14/258 (5%) Query: 45 ACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYY-P 103 ACG + V GG +S WPW S++ H C GSLL+ RWV++AAHCF+ + P Sbjct: 40 ACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKP 99 Query: 104 SEWTVQLGELTSRPTPWNLRAYSSR-YKVQDIIVNPDALGVLRN----DIALLRLASSVT 158 ++V LG W L SR KV V P + + DIAL+RL S+ Sbjct: 100 YLFSVLLGA-------WQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQ 152 Query: 159 YNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYL 218 ++ + PIC+ ++ + CW++GWG I G PLP P L++ +V I+++ C++L Sbjct: 153 FSERVLPICLPDASIHLPPNTHCWISGWGSIQ-DGVPLPHPQTLQKLKVPIIDSEVCSHL 211 Query: 219 FEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNR 278 + + + + I + M CAG +G D C GDSGGPL+C DG W GI+SWG C + NR Sbjct: 212 YWRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNR 271 Query: 279 PGVYTNISVYFHWIRRVM 296 PGVY ++S + W+ +++ Sbjct: 272 PGVYISLSAHRSWVEKIV 289 >gi|187761337 transmembrane protease, serine 11B [Homo sapiens] Length = 416 Score = 185 bits (469), Expect = 5e-47 Identities = 100/254 (39%), Positives = 147/254 (57%), Gaps = 21/254 (8%) Query: 46 CGHREIHALVAG-----GVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKH 100 CG + ++++ G G S G WPWQAS++ + RH CG SL+S RW+LSAAHCF K Sbjct: 171 CGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKK 230 Query: 101 YYPSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPD-ALGVLRNDIALLRLASSVTY 159 +WTV G + ++P Y +R KVQ+II + + + L +DIAL++LA V++ Sbjct: 231 NNSKDWTVNFGIVVNKP-------YMTR-KVQNIIFHENYSSPGLHDDIALVQLAEEVSF 282 Query: 160 NAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLF 219 YI+ IC+ + + VTGWG + +G+ P L+E + I++N CN + Sbjct: 283 TEYIRKICLPEAKMKLSENDNVVVTGWGTLYMNGS---FPVILQEDFLKIIDNKICNASY 339 Query: 220 EQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVC-DKDGLWYQVGIVSWGMDCGQPNR 278 + + D+M CAG G D C+ DSGGPL D +W+ VGIVSWG CG+ N+ Sbjct: 340 ---AYSGFVTDTMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNK 396 Query: 279 PGVYTNISVYFHWI 292 PGVYT ++ Y +WI Sbjct: 397 PGVYTRVTSYRNWI 410 >gi|239753545 PREDICTED: similar to hCG2041452 [Homo sapiens] Length = 410 Score = 183 bits (465), Expect = 2e-46 Identities = 108/288 (37%), Positives = 149/288 (51%), Gaps = 26/288 (9%) Query: 16 AGLGKPGELGALQAGPGAARRPGGG---GRE--EACGHREIHALVAGGVESARGRWPWQA 70 A G PG + G A G GR+ +ACGHR + GG+ + +WPWQ Sbjct: 121 ATAGPPGSWVTSASTVGEALESDGISDLGRQFSQACGHRVSRMI--GGLPAPNKKWPWQV 178 Query: 71 SLRLRRRHRCGGSLLSRRWVLSAAHCFQKH--YYPSEWTVQLGELTSRPTPWNLRAYSSR 128 SL+ H CGGSL+ RRWVL+AAHC + + W + + + Sbjct: 179 SLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWEGGRWLLA-----------GIGRWDQA 227 Query: 129 YKVQDIIVNPDAL--GVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPDCWVTGW 186 +K + I+ P L +DIAL LA SV Y+++IQP C+ F +CWVTGW Sbjct: 228 WKHLEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPACLPEKLFEVEAGTECWVTGW 287 Query: 187 GLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQP--SSRSMIWDSMFCAGAEDGSVDT 244 G +S S + P P L+E ++ I+ + +C + + S M+ C G D D Sbjct: 288 GQVSESVSG-PMPLVLQETELNIMRHEKCCEMLKNKNISKSKMVTRGTVC-GYNDQGKDA 345 Query: 245 CKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWI 292 C+GDSGGPLVC+ +G W QVGIVSWG+ CG+ PGVYT +S Y WI Sbjct: 346 CQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPGVYTEVSFYKKWI 393 >gi|239748117 PREDICTED: hypothetical protein XP_002346556 [Homo sapiens] Length = 410 Score = 183 bits (465), Expect = 2e-46 Identities = 108/288 (37%), Positives = 149/288 (51%), Gaps = 26/288 (9%) Query: 16 AGLGKPGELGALQAGPGAARRPGGG---GRE--EACGHREIHALVAGGVESARGRWPWQA 70 A G PG + G A G GR+ +ACGHR + GG+ + +WPWQ Sbjct: 121 ATAGPPGSWVTSASTVGEALESDGISDLGRQFSQACGHRVSRMI--GGLPAPNKKWPWQV 178 Query: 71 SLRLRRRHRCGGSLLSRRWVLSAAHCFQKH--YYPSEWTVQLGELTSRPTPWNLRAYSSR 128 SL+ H CGGSL+ RRWVL+AAHC + + W + + + Sbjct: 179 SLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWEGGRWLLA-----------GIGRWDQA 227 Query: 129 YKVQDIIVNPDAL--GVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPDCWVTGW 186 +K + I+ P L +DIAL LA SV Y+++IQP C+ F +CWVTGW Sbjct: 228 WKHLEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPACLPEKLFEVEAGTECWVTGW 287 Query: 187 GLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQP--SSRSMIWDSMFCAGAEDGSVDT 244 G +S S + P P L+E ++ I+ + +C + + S M+ C G D D Sbjct: 288 GQVSESVSG-PMPLVLQETELNIMRHEKCCEMLKNKNISKSKMVTRGTVC-GYNDQGKDA 345 Query: 245 CKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWI 292 C+GDSGGPLVC+ +G W QVGIVSWG+ CG+ PGVYT +S Y WI Sbjct: 346 CQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPGVYTEVSFYKKWI 393 >gi|239742016 PREDICTED: hypothetical protein XP_002342392 [Homo sapiens] Length = 410 Score = 183 bits (465), Expect = 2e-46 Identities = 108/288 (37%), Positives = 149/288 (51%), Gaps = 26/288 (9%) Query: 16 AGLGKPGELGALQAGPGAARRPGGG---GRE--EACGHREIHALVAGGVESARGRWPWQA 70 A G PG + G A G GR+ +ACGHR + GG+ + +WPWQ Sbjct: 121 ATAGPPGSWVTSASTVGEALESDGISDLGRQFSQACGHRVSRMI--GGLPAPNKKWPWQV 178 Query: 71 SLRLRRRHRCGGSLLSRRWVLSAAHCFQKH--YYPSEWTVQLGELTSRPTPWNLRAYSSR 128 SL+ H CGGSL+ RRWVL+AAHC + + W + + + Sbjct: 179 SLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWEGGRWLLA-----------GIGRWDQA 227 Query: 129 YKVQDIIVNPDAL--GVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHRPDCWVTGW 186 +K + I+ P L +DIAL LA SV Y+++IQP C+ F +CWVTGW Sbjct: 228 WKHLEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPACLPEKLFEVEAGTECWVTGW 287 Query: 187 GLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQP--SSRSMIWDSMFCAGAEDGSVDT 244 G +S S + P P L+E ++ I+ + +C + + S M+ C G D D Sbjct: 288 GQVSESVSG-PMPLVLQETELNIMRHEKCCEMLKNKNISKSKMVTRGTVC-GYNDQGKDA 345 Query: 245 CKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWI 292 C+GDSGGPLVC+ +G W QVGIVSWG+ CG+ PGVYT +S Y WI Sbjct: 346 CQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPGVYTEVSFYKKWI 393 >gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sapiens] Length = 432 Score = 182 bits (463), Expect = 3e-46 Identities = 95/251 (37%), Positives = 138/251 (54%), Gaps = 13/251 (5%) Query: 45 ACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPS 104 ACG V GG E++ WPWQ S++ ++H CGGS+L WVL+AAHCF+KH Sbjct: 190 ACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVF 249 Query: 105 EWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQ 164 W V+ G L ++ S + II+ + + NDIAL++L +T++ ++ Sbjct: 250 NWKVRAGS-------DKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVR 302 Query: 165 PICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSS 224 PIC+ W+ GWG +G + L +A V ++++TRCN + Sbjct: 303 PICLPFFDEELTPATPLWIIGWGFTKQNGGKMSD--ILLQASVQVIDSTRCN---ADDAY 357 Query: 225 RSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTN 284 + + + M CAG +G VDTC+GDSGGPL+ D W+ VGIVSWG CG P+ PGVYT Sbjct: 358 QGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD-QWHVVGIVSWGYGCGGPSTPGVYTK 416 Query: 285 ISVYFHWIRRV 295 +S Y +WI V Sbjct: 417 VSAYLNWIYNV 427 >gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sapiens] Length = 437 Score = 182 bits (463), Expect = 3e-46 Identities = 95/251 (37%), Positives = 138/251 (54%), Gaps = 13/251 (5%) Query: 45 ACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPS 104 ACG V GG E++ WPWQ S++ ++H CGGS+L WVL+AAHCF+KH Sbjct: 195 ACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVF 254 Query: 105 EWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQ 164 W V+ G L ++ S + II+ + + NDIAL++L +T++ ++ Sbjct: 255 NWKVRAGS-------DKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVR 307 Query: 165 PICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSS 224 PIC+ W+ GWG +G + L +A V ++++TRCN + Sbjct: 308 PICLPFFDEELTPATPLWIIGWGFTKQNGGKMSD--ILLQASVQVIDSTRCN---ADDAY 362 Query: 225 RSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTN 284 + + + M CAG +G VDTC+GDSGGPL+ D W+ VGIVSWG CG P+ PGVYT Sbjct: 363 QGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD-QWHVVGIVSWGYGCGGPSTPGVYTK 421 Query: 285 ISVYFHWIRRV 295 +S Y +WI V Sbjct: 422 VSAYLNWIYNV 432 >gi|23957702 transmembrane protease, serine 6 [Homo sapiens] Length = 811 Score = 179 bits (455), Expect = 2e-45 Identities = 98/268 (36%), Positives = 148/268 (55%), Gaps = 20/268 (7%) Query: 36 RPGGGGREEACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAH 95 R G CG + + + GG S+ G WPWQASL++R RH CGG+L++ RWV++AAH Sbjct: 558 RDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAH 617 Query: 96 CFQKHYYPSE--WTVQLGELTSRPTPWNLRAYSSR--YKVQDIIVNPDALGVLRN-DIAL 150 CFQ+ S WTV LG++ W + +KV ++++P + D+AL Sbjct: 618 CFQEDSMASTVLWTVFLGKV------WQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVAL 671 Query: 151 LRLASSVTYNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTIL 210 L+L V +A ++P+C+ + + F CW+TGWG + G P L++ V ++ Sbjct: 672 LQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGG---PISNALQKVDVQLI 728 Query: 211 NNTRCNYLFEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDK-DGLWYQVGIVSW 269 C+ ++ R + M CAG G D C+GDSGGPLVC G W+ G+VSW Sbjct: 729 PQDLCSEVY-----RYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSW 783 Query: 270 GMDCGQPNRPGVYTNISVYFHWIRRVMS 297 G+ CG+PN GVYT I+ WI++V++ Sbjct: 784 GLGCGRPNYFGVYTRITGVISWIQQVVT 811 >gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sapiens] Length = 529 Score = 175 bits (444), Expect = 4e-44 Identities = 91/259 (35%), Positives = 142/259 (54%), Gaps = 20/259 (7%) Query: 45 ACG---HREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHY 101 ACG + + + GG + G WPWQ SL ++ H CGGS+++ W+++AAHC +K Sbjct: 280 ACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPL 339 Query: 102 Y-PSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRN-DIALLRLASSVTY 159 P WT G L + Y + Y+V+ +I +P+ +N DIAL++L +T+ Sbjct: 340 NNPWHWTAFAGILRQ-----SFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTF 394 Query: 160 NAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCN--Y 217 N ++P+C+ + CW++GWG G L A+V ++ RCN Y Sbjct: 395 NDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEV---LNAAKVLLIETQRCNSRY 451 Query: 218 LFEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPN 277 +++ ++I +M CAG G+VD+C+GDSGGPLV K+ +W+ +G SWG C + Sbjct: 452 VYD-----NLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAY 506 Query: 278 RPGVYTNISVYFHWIRRVM 296 RPGVY N+ V+ WI R M Sbjct: 507 RPGVYGNVMVFTDWIYRQM 525 >gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sapiens] Length = 492 Score = 175 bits (444), Expect = 4e-44 Identities = 91/259 (35%), Positives = 142/259 (54%), Gaps = 20/259 (7%) Query: 45 ACG---HREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHY 101 ACG + + + GG + G WPWQ SL ++ H CGGS+++ W+++AAHC +K Sbjct: 243 ACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPL 302 Query: 102 Y-PSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRN-DIALLRLASSVTY 159 P WT G L + Y + Y+V+ +I +P+ +N DIAL++L +T+ Sbjct: 303 NNPWHWTAFAGILRQ-----SFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTF 357 Query: 160 NAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCN--Y 217 N ++P+C+ + CW++GWG G L A+V ++ RCN Y Sbjct: 358 NDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEV---LNAAKVLLIETQRCNSRY 414 Query: 218 LFEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPN 277 +++ ++I +M CAG G+VD+C+GDSGGPLV K+ +W+ +G SWG C + Sbjct: 415 VYD-----NLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAY 469 Query: 278 RPGVYTNISVYFHWIRRVM 296 RPGVY N+ V+ WI R M Sbjct: 470 RPGVYGNVMVFTDWIYRQM 488 >gi|223942069 enterokinase precursor [Homo sapiens] Length = 1019 Score = 174 bits (440), Expect = 1e-43 Identities = 97/261 (37%), Positives = 140/261 (53%), Gaps = 26/261 (9%) Query: 44 EACGHR----EIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHC-FQ 98 ++CG + +I + GG + G WPW L R CG SL+S W++SAAHC + Sbjct: 770 KSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYG 829 Query: 99 KHYYPSEWTVQLG-----ELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLR-NDIALLR 152 ++ PS+WT LG LTS T L + +I++NP + NDIA++ Sbjct: 830 RNLEPSKWTAILGLHMKSNLTSPQTVPRL--------IDEIVINPHYNRRRKDNDIAMMH 881 Query: 153 LASSVTYNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNN 212 L V Y YIQPIC+ F +C + GWG + GT L+EA V +L+N Sbjct: 882 LEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANI---LQEADVPLLSN 938 Query: 213 TRCNYLFEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMD 272 RC +Q I ++M CAG E+G +D+C+GDSGGPL+C ++ W+ G+ S+G Sbjct: 939 ERC----QQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYK 994 Query: 273 CGQPNRPGVYTNISVYFHWIR 293 C PNRPGVY +S + WI+ Sbjct: 995 CALPNRPGVYARVSRFTEWIQ 1015 >gi|40254871 transmembrane protease, serine 11E [Homo sapiens] Length = 423 Score = 172 bits (435), Expect = 5e-43 Identities = 95/253 (37%), Positives = 137/253 (54%), Gaps = 19/253 (7%) Query: 46 CGHREIHAL-----VAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKH 100 CG R L + GG E G WPWQASL+ HRCG +L++ W++SAAHCF + Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237 Query: 101 YYPSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYN 160 P+ WT G +T +P+ ++ R V + +P DI+L L+S V Y Sbjct: 238 KNPARWTASFG-VTIKPS--KMKRGLRRIIVHEKYKHPSH----DYDISLAELSSPVPYT 290 Query: 161 AYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFE 220 + +C+ +++ F +VTG+G + G +LR+AQVT+++ T CN E Sbjct: 291 NAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGY---SQNHLRQAQVTLIDATTCN---E 344 Query: 221 QPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLV-CDKDGLWYQVGIVSWGMDCGQPNRP 279 + I M CAG+ +G D C+GDSGGPLV D +WY GIVSWG +C +PN+P Sbjct: 345 PQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKP 404 Query: 280 GVYTNISVYFHWI 292 GVYT ++ WI Sbjct: 405 GVYTRVTALRDWI 417 >gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens] Length = 423 Score = 172 bits (435), Expect = 5e-43 Identities = 95/253 (37%), Positives = 137/253 (54%), Gaps = 19/253 (7%) Query: 46 CGHREIHAL-----VAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKH 100 CG R L + GG E G WPWQASL+ HRCG +L++ W++SAAHCF + Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237 Query: 101 YYPSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYN 160 P+ WT G +T +P+ ++ R V + +P DI+L L+S V Y Sbjct: 238 KNPARWTASFG-VTIKPS--KMKRGLRRIIVHEKYKHPSH----DYDISLAELSSPVPYT 290 Query: 161 AYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFE 220 + +C+ +++ F +VTG+G + G +LR+AQVT+++ T CN E Sbjct: 291 NAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGY---SQNHLRQAQVTLIDATTCN---E 344 Query: 221 QPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLV-CDKDGLWYQVGIVSWGMDCGQPNRP 279 + I M CAG+ +G D C+GDSGGPLV D +WY GIVSWG +C +PN+P Sbjct: 345 PQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKP 404 Query: 280 GVYTNISVYFHWI 292 GVYT ++ WI Sbjct: 405 GVYTRVTALRDWI 417 >gi|68508970 tryptase beta 2 precursor [Homo sapiens] Length = 275 Score = 171 bits (434), Expect = 6e-43 Identities = 94/246 (38%), Positives = 133/246 (54%), Gaps = 17/246 (6%) Query: 55 VAGGVESARGRWPWQASLRLRRR---HRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLG 111 + GG E+ R +WPWQ SLR+R R H CGGSL+ +WVL+AAHC L Sbjct: 31 IVGGQEAPRSKWPWQVSLRVRDRYWMHFCGGSLIHPQWVLTAAHCVGPD------VKDLA 84 Query: 112 ELTSRPTPWNLRAYSSRYKVQDIIVNPDALGV-LRNDIALLRLASSVTYNAYIQPICIES 170 L + +L V IIV+P + DIALL L V ++++ + + Sbjct: 85 ALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPP 144 Query: 171 STFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRS---- 226 ++ F CWVTGWG + + LPPP+ L++ +V I+ N C+ + + Sbjct: 145 ASETFPPGMPCWVTGWGDVD-NDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVR 203 Query: 227 MIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNIS 286 ++ D M CAG + D+C+GDSGGPLVC +G W Q G+VSWG C QPNRPG+YT ++ Sbjct: 204 IVRDDMLCAG--NTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVT 261 Query: 287 VYFHWI 292 Y WI Sbjct: 262 YYLDWI 267 >gi|194018492 transmembrane protease, serine 11F [Homo sapiens] Length = 438 Score = 171 bits (434), Expect = 6e-43 Identities = 92/241 (38%), Positives = 134/241 (55%), Gaps = 16/241 (6%) Query: 54 LVAGGVESARGRWPWQASLRL-RRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGE 112 +V G + G WPWQASL+L H+CG SL+S W+L+AAHCF K+ P++W G Sbjct: 206 IVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQWIATFGA 265 Query: 113 LTSRPTPWNLRAYSSRYKVQDIIVNPDA-LGVLRNDIALLRLASSVTYNAYIQPICIESS 171 + P + + V+ II++ + NDIAL++L++ V ++ +Q +C+ S Sbjct: 266 TITPP--------AVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDS 317 Query: 172 TFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDS 231 + + +VTG+G I G P LR+A+V ++ CN + +I Sbjct: 318 SIKLPPKTSVFVTGFGSIVDDG---PIQNTLRQARVETISTDVCN---RKDVYDGLITPG 371 Query: 232 MFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHW 291 M CAG +G +D CKGDSGGPLV D +WY VGIVSWG C P +PGVYT ++ Y W Sbjct: 372 MLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDW 431 Query: 292 I 292 I Sbjct: 432 I 432 >gi|116256363 transmembrane protease, serine 13 [Homo sapiens] Length = 567 Score = 171 bits (433), Expect = 8e-43 Identities = 95/251 (37%), Positives = 133/251 (52%), Gaps = 17/251 (6%) Query: 46 CGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCF--QKHYYP 103 CG R + + GG ++ +WPWQ SL H CGG+L+ +WVL+AAHCF + Sbjct: 317 CGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVL 376 Query: 104 SEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRN-DIALLRLASSVTYNAY 162 W V G TS NL + +II+N + + DIAL+RL+ +T +A+ Sbjct: 377 EGWKVYAG--TS-----NLHQLPEAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAH 429 Query: 163 IQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCN-YLFEQ 221 I P C+ F CW+TG+G + P LRE QV +++ +CN YL Sbjct: 430 IHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSP--FLREVQVNLIDFKKCNDYLVYD 487 Query: 222 PSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGV 281 S + M CAG G D+C+GDSGGPLVC+++ WY G+ SWG CGQ N+PGV Sbjct: 488 ----SYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGV 543 Query: 282 YTNISVYFHWI 292 YT ++ WI Sbjct: 544 YTKVTEVLPWI 554 >gi|78191798 plasma kallikrein B1 precursor [Homo sapiens] Length = 638 Score = 171 bits (432), Expect = 1e-42 Identities = 88/246 (35%), Positives = 134/246 (54%), Gaps = 23/246 (9%) Query: 55 VAGGVESARGRWPWQASLRLR---RRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLG 111 + GG S+ G WPWQ SL+++ +RH CGGSL+ +WVL+AAHCF W + G Sbjct: 391 IVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSG 450 Query: 112 ELT----SRPTPWNLRAYSSRYKVQDIIVNPD-ALGVLRNDIALLRLASSVTYNAYIQPI 166 L ++ TP++ ++++II++ + + +DIAL++L + + Y + +PI Sbjct: 451 ILNLSDITKDTPFS--------QIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPI 502 Query: 167 CIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRS 226 C+ S +CWVTGWG G L++ + ++ N C ++ Sbjct: 503 CLPSKGDTSTIYTNCWVTGWGFSKEKGEI---QNILQKVNIPLVTNEECQKRYQDYK--- 556 Query: 227 MIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNIS 286 I M CAG ++G D CKGDSGGPLVC +G+W VGI SWG C + +PGVYT ++ Sbjct: 557 -ITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVA 615 Query: 287 VYFHWI 292 Y WI Sbjct: 616 EYMDWI 621 >gi|4503627 coagulation factor XI precursor [Homo sapiens] Length = 625 Score = 169 bits (428), Expect = 3e-42 Identities = 94/247 (38%), Positives = 128/247 (51%), Gaps = 15/247 (6%) Query: 50 EIHALVAGGVESARGRWPWQASLRLR---RRHRCGGSLLSRRWVLSAAHCFQKHYYPSEW 106 +I + GG S RG WPWQ +L +RH CGGS++ +W+L+AAHCF P Sbjct: 383 KIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKIL 442 Query: 107 TVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPD-ALGVLRNDIALLRLASSVTYNAYIQP 165 V G L ++ +S + VQ+II++ + DIALL+L ++V Y +P Sbjct: 443 RVYSGILNQS----EIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRP 498 Query: 166 ICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSR 225 IC+ S V DCWVTGWG L++A++ ++ N C + Sbjct: 499 ICLPSKGDRNVIYTDCWVTGWGYRKLRDKI---QNTLQKAKIPLVTNEECQKRYRGHK-- 553 Query: 226 SMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNI 285 I M CAG +G D CKGDSGGPL C + +W+ VGI SWG C Q RPGVYTN+ Sbjct: 554 --ITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNV 611 Query: 286 SVYFHWI 292 Y WI Sbjct: 612 VEYVDWI 618 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.322 0.138 0.462 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,699,967 Number of Sequences: 37866 Number of extensions: 739047 Number of successful extensions: 3153 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 179 Number of HSP's successfully gapped in prelim test: 31 Number of HSP's that attempted gapping in prelim test: 2487 Number of HSP's gapped (non-prelim): 252 length of query: 318 length of database: 18,247,518 effective HSP length: 102 effective length of query: 216 effective length of database: 14,385,186 effective search space: 3107200176 effective search space used: 3107200176 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.