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Search of human proteins with 203097724
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|203097724 cadherin-like 29 [Homo sapiens]
(788 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|203097724 cadherin-like 29 [Homo sapiens] 1583 0.0
gi|40255133 hypothetical protein LOC222256 [Homo sapiens] 127 3e-29
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 101 3e-21
gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precurso... 101 3e-21
gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precurs... 101 3e-21
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 99 2e-20
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 92 1e-18
gi|16933557 dachsous 1 precursor [Homo sapiens] 92 2e-18
gi|169171663 PREDICTED: similar to hCG2036731 [Homo sapiens] 92 2e-18
gi|239749177 PREDICTED: similar to hCG2036731 [Homo sapiens] 92 2e-18
gi|239508938 PREDICTED: similar to hCG2036731 [Homo sapiens] 92 2e-18
gi|169171173 PREDICTED: similar to hCG2036731 [Homo sapiens] 91 3e-18
gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens] 90 9e-18
gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens] 90 9e-18
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 89 1e-17
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 89 2e-17
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 89 2e-17
gi|14165405 protocadherin alpha 2 isoform 2 precursor [Homo sapi... 88 3e-17
gi|9256584 protocadherin alpha 2 isoform 1 precursor [Homo sapiens] 88 3e-17
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens] 87 6e-17
gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens] 87 6e-17
gi|14195605 protocadherin beta 16 precursor [Homo sapiens] 84 7e-16
gi|14277677 protocadherin gamma subfamily C, 3 isoform 2 precurs... 83 9e-16
gi|14277675 protocadherin gamma subfamily C, 3 isoform 1 precurs... 83 9e-16
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 83 1e-15
gi|14196471 protocadherin gamma subfamily A, 5 isoform 2 precurs... 82 1e-15
gi|11056024 protocadherin gamma subfamily A, 5 isoform 1 precurs... 82 1e-15
gi|14717401 protocadherin alpha subfamily C, 1 isoform 1 precurs... 82 3e-15
gi|14717403 protocadherin alpha subfamily C, 1 isoform 2 precurs... 82 3e-15
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens] 80 6e-15
>gi|203097724 cadherin-like 29 [Homo sapiens]
Length = 788
Score = 1583 bits (4099), Expect = 0.0
Identities = 788/788 (100%), Positives = 788/788 (100%)
Query: 1 MVLLRLLVFLFAPVVSDLCSLPCFINVSESQGPGTVLQFLSFNCSSYTPTPTLELLNVQP 60
MVLLRLLVFLFAPVVSDLCSLPCFINVSESQGPGTVLQFLSFNCSSYTPTPTLELLNVQP
Sbjct: 1 MVLLRLLVFLFAPVVSDLCSLPCFINVSESQGPGTVLQFLSFNCSSYTPTPTLELLNVQP 60
Query: 61 PTTFFNPPSLARWQGTYVGKLTLSSSAQLDALMVNHYKVQLKFTCGNHVMEGSLSVDVQR 120
PTTFFNPPSLARWQGTYVGKLTLSSSAQLDALMVNHYKVQLKFTCGNHVMEGSLSVDVQR
Sbjct: 61 PTTFFNPPSLARWQGTYVGKLTLSSSAQLDALMVNHYKVQLKFTCGNHVMEGSLSVDVQR 120
Query: 121 DLSHIQCAGQFASPAGEMIQVPETVTPGARLYTLLLPGLELHGAQMSIISAQDLPHFPGP 180
DLSHIQCAGQFASPAGEMIQVPETVTPGARLYTLLLPGLELHGAQMSIISAQDLPHFPGP
Sbjct: 121 DLSHIQCAGQFASPAGEMIQVPETVTPGARLYTLLLPGLELHGAQMSIISAQDLPHFPGP 180
Query: 181 FSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQA 240
FSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQA
Sbjct: 181 FSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQA 240
Query: 241 QNITIPENLAPGSEVVQVQARGVDLRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSG 300
QNITIPENLAPGSEVVQVQARGVDLRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSG
Sbjct: 241 QNITIPENLAPGSEVVQVQARGVDLRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSG 300
Query: 301 TAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTL 360
TAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTL
Sbjct: 301 TAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTL 360
Query: 361 TCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDG 420
TCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDG
Sbjct: 361 TCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDG 420
Query: 421 GQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYY 480
GQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYY
Sbjct: 421 GQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYY 480
Query: 481 TSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEV 540
TSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEV
Sbjct: 481 TSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEV 540
Query: 541 EDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFIL 600
EDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFIL
Sbjct: 541 EDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFIL 600
Query: 601 QGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATS 660
QGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATS
Sbjct: 601 QGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATS 660
Query: 661 THRTTVPSTMTPMLVTDTEAFWQPQPWFVVVLTATGALLLLALGWLLGRLLQGLAQLLQA 720
THRTTVPSTMTPMLVTDTEAFWQPQPWFVVVLTATGALLLLALGWLLGRLLQGLAQLLQA
Sbjct: 661 THRTTVPSTMTPMLVTDTEAFWQPQPWFVVVLTATGALLLLALGWLLGRLLQGLAQLLQA 720
Query: 721 PSKPAQALLLNSIQGTEGSIEGFLEAPKMEMSQAPSSVMSLHFDGRAQDSRTGRDYLFNT 780
PSKPAQALLLNSIQGTEGSIEGFLEAPKMEMSQAPSSVMSLHFDGRAQDSRTGRDYLFNT
Sbjct: 721 PSKPAQALLLNSIQGTEGSIEGFLEAPKMEMSQAPSSVMSLHFDGRAQDSRTGRDYLFNT 780
Query: 781 HTGARRWL 788
HTGARRWL
Sbjct: 781 HTGARRWL 788
>gi|40255133 hypothetical protein LOC222256 [Homo sapiens]
Length = 885
Score = 127 bits (320), Expect = 3e-29
Identities = 200/852 (23%), Positives = 329/852 (38%), Gaps = 120/852 (14%)
Query: 1 MVLLRLLVFLFAPVVSDLCSLPCFINVSESQGPGTVLQFLSFNCSSYTPTPTL----ELL 56
++LL LL + L LP NV+E+ PGT + S S+ + +P + +++
Sbjct: 5 IILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSA-SLSPVIPGFPQIV 63
Query: 57 NVQPPTTFFNPPSLARWQGTYVGKLTLSSSAQLDALMVNHYKVQLKFTCGNHVMEGSLSV 116
N P T F L+ GTY +T QL F G ++ + + V
Sbjct: 64 NSNPLTEAFRVNWLS---GTYFEVVTTGME-------------QLDFETGPNIFDLQIYV 107
Query: 117 DVQRDLSHIQCAGQFASPAGEMIQVPETVTPGARLYTL--LLPGLELHGAQMSIISAQD- 173
+ ++ +Q + E Q + G LY + PG Q+ +D
Sbjct: 108 KDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIY---QVEAFDPEDT 164
Query: 174 -----LPHF----PGPFSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIV 224
L +F P F ++ G L + ++ + F L + V + V
Sbjct: 165 SRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQV 224
Query: 225 KVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD-------LRYEILSPVPSPL 277
++ + F + T+ E L+PG+ V + A D L Y I + S
Sbjct: 225 NIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTV--SKY 282
Query: 278 FSIGRADGVVRTTTPLELARTSG----TAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNL 333
F I + G ++ ++ R +G L+V ++ ++ +T V+ VN
Sbjct: 283 FMINQLTGTIQVAQRID--RDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVND 340
Query: 334 WPPRCLPALLVSQIPETAPVGTVLNTLT--CEDPDSVGATLDYKLWFRSSSNPASLCLYD 391
P C +PE GT+L L C D DS + S S L D
Sbjct: 341 NPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQD 400
Query: 392 RV----LEVNATLDCDTPG---ACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPA 444
+ + LD + P A ++ I V D P V V ++ +P NEF P
Sbjct: 401 PAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEF-PL 459
Query: 445 CAPR---TFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGG------PTTFAVDRLSG 495
R F V E T +G V TD D P ++ Y S G P F ++ +G
Sbjct: 460 IFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTG 519
Query: 496 EVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPP-- 553
E+ L+ +D E +Y L + Q N+ + S T+T+ + + ND P C P
Sbjct: 520 ELQLVTKVDCETTPIYILRI--------QATNNEDTSSVTVTVNILEENDEKPICTPNSY 571
Query: 554 FQELTIYAPLGRSVEVTKMSC-QIPQEPQRLIYSYSIVGGNSQNRFILQG--------AI 604
F L + +G +++ K++C + P+ + YSI GN N F +
Sbjct: 572 FLALPVDLKVGTNIQNFKLTCTDLDSSPRS--FRYSIGPGNVNNHFTFSPNAGSNVTRLL 629
Query: 605 LVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLST-------TATIIVHLVPRRASTV 657
L G F ++ Y+LL+ V D + T T+ + ++P +T+
Sbjct: 630 LTSRFDYAGGF--DKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPH-PTTI 686
Query: 658 ATSTHRTTVPSTMTPMLVTDTEAFWQPQPWFVVVLTATGALLLLALGWLLGRLLQGLAQL 717
T+T R V + V + P W+V + G++LLL L L L+ LA+
Sbjct: 687 ITTTPRPRVTYQVLRKNV------YSPSAWYVPFVITLGSILLLGL---LVYLVVLLAKA 737
Query: 718 LQ--APSKPAQALLLNSIQGTEGSIEGFLEAPKMEMSQAPSSVMSLHFDGRAQDSRTGRD 775
+ P K + + +G + E + ++M+ FDG A D TG
Sbjct: 738 IHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTI--------FDGEAIDPVTGET 789
Query: 776 YLFNTHTGARRW 787
Y FN+ TGAR+W
Sbjct: 790 YEFNSKTGARKW 801
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 101 bits (251), Expect = 3e-21
Identities = 138/550 (25%), Positives = 229/550 (41%), Gaps = 48/550 (8%)
Query: 141 VPETVTPGARLYTLLLPGLE--LHGAQMSIISAQDLPHFPGPFSINEQGWLQAPSQGLLG 198
+PE PG+ + +L + ++G I++ D G F +N + ++ L
Sbjct: 1850 IPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDED---GIFFLNPITGVFNLTRLLDY 1906
Query: 199 QAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQV 258
+ Q+ + L + G Q V +L V + F + + ++ ENL GS V+
Sbjct: 1907 EVQQYYILTVRAEDGGGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVF 1966
Query: 259 QARGVD------LRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFE 312
D L Y I S F++ + +GV++ L+ S L V+ +
Sbjct: 1967 NVTDADDGINSQLTYSIASGDSLGQFTVDK-NGVLKVLKALDRESQS---FYNLVVQVHD 2022
Query: 313 QGQLWASAKLNLTMNVQL----VNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDS- 367
Q+ AS + T V + VN PP L L + IPE P+ TV+ DPDS
Sbjct: 2023 LPQIPAS-RFTSTAQVSIILLDVNDNPPTFLSPKL-TYIPENTPIDTVVFKAQATDPDSG 2080
Query: 368 VGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTT 427
+ ++Y L N S+ D + + LD + + +++ D GQP +++
Sbjct: 2081 PNSYIEYTL-LNPLGNKFSIGTIDGEVRLTGELDREEVS---NYTLTVVATDKGQPSLSS 2136
Query: 428 EVPVLVMVTPINEFSPACAPRTFRVQ--EDAAPHTLLGSVVGTDMDY-PHDNIEYYTSGG 484
V+VMV IN+ +P A ++V+ E+ T + V D D + + Y G
Sbjct: 2137 STEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNG 2196
Query: 485 PTT--FAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVED 542
T F +D ++G + + PLD E+ Y LTV D G + + T++I + D
Sbjct: 2197 NTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTD-----TSTVSIVLLD 2251
Query: 543 VNDHAPECEPPFQELTIYAPLGRSVE-VTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQ 601
+ND P E + + LG + ++ + SY + GGN N F L
Sbjct: 2252 INDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLS 2311
Query: 602 --GAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATI--IVHLVPRRASTV 657
G + V L E + L+I D+G +P L+ T TI IV V T
Sbjct: 2312 ASGELGVTQSLDR-----ETKERFVLMITATDSG--SPALTGTGTINVIVDDVNDNVPTF 2364
Query: 658 ATSTHRTTVP 667
A+ + TT+P
Sbjct: 2365 ASKAYFTTIP 2374
Score = 94.7 bits (234), Expect = 3e-19
Identities = 124/589 (21%), Positives = 240/589 (40%), Gaps = 36/589 (6%)
Query: 83 LSSSAQLDALMVNHYKVQLKFTCGNHVMEGSLSVDVQRDLSHIQCAGQFASPAGEMIQVP 142
+S+ LD Y++Q+ T G ++ + ++ L F+ A + V
Sbjct: 745 ISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFV-VF 803
Query: 143 ETVTPGARLYTLLLPGLELHGAQMSIISAQDLPHFPGPFSINEQGWLQAPSQGLLGQAQK 202
E V G + ++ ++L+ +I+ D G F+IN+ + + + Q
Sbjct: 804 ENVALGYHVGSVSASTMDLNSNISYLITTGDQK---GMFAINQVTGQLTTANVIDREEQS 860
Query: 203 VFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARG 262
+QL++ V+ G + MV + V + + FL+ +++ + EN G + Q +A
Sbjct: 861 FYQLKV-VASGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVD 919
Query: 263 VD-----LRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLW 317
D + L P LF+I +G + PL++ S ++++ A + G
Sbjct: 920 PDEGVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLDVHAGS----YQIEILASDMGVPQ 975
Query: 318 ASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLW 377
S+ + LT+ V VN P + E+ PV + + D DS GA +
Sbjct: 976 LSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDS-GANGEIAYT 1034
Query: 378 FRSSSNPASLCLY-DRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVT 436
+ + ++ D L + + LD + ++ ++ D ++ V V V++
Sbjct: 1035 IAEGNTGDAFGIFPDGQLYIKSELDRELQD---RYVLMVVASDRAVEPLSATVNVTVILE 1091
Query: 437 PINEFSPA--CAPRTFRVQEDAAPHTLLGSVVGTDMDY-PHDNIEYYTSGGPTTFAVDRL 493
+N+ P TF +E+ + +G V D D+ P+ + Y F + +
Sbjct: 1092 DVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDFELHAI 1151
Query: 494 SGEVHLLGPLDYEQ------QRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHA 547
SGE+ D E ++ TV+ D G Q L T+ + ++D+ND+A
Sbjct: 1152 SGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQP----LKDQATVHVYMKDINDNA 1207
Query: 548 PECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVH 607
P+ F + TI +V ++S E + YSI+ GN + +F +
Sbjct: 1208 PKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDST--SG 1265
Query: 608 SDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRAST 656
++G E Y L+I D+G T L++T T+ + ++ +T
Sbjct: 1266 QVTLIGKLDYEATPAYSLVIQAVDSG--TIPLNSTCTLNIDILDENDNT 1312
Score = 81.6 bits (200), Expect = 3e-15
Identities = 113/454 (24%), Positives = 180/454 (39%), Gaps = 44/454 (9%)
Query: 216 QSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD------LRYEI 269
QS + + V V F + IPE+ PGS V + A D + Y +
Sbjct: 1821 QSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIV 1880
Query: 270 LSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQ 329
+F + GV T L+ L V+A + G + + + + N+
Sbjct: 1881 NEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYI---LTVRAEDGGGQFTT--IRVYFNIL 1935
Query: 330 LVNLWPPRCLPALLVSQIPETAPVG-TVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLC 388
VN PP + + E PVG TVL + D + + L Y + +S +
Sbjct: 1936 DVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSI---ASGDSLGQF 1992
Query: 389 LYDR--VLEVNATLDCDTPGACFQHAASILVLDGGQPQM-----TTEVPVLVMVTPINEF 441
D+ VL+V LD ++ Q +++V PQ+ T+ V +++ +N+
Sbjct: 1993 TVDKNGVLKVLKALDRES-----QSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDN 2047
Query: 442 SPA-CAPRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGP--TTFAVDRLSGEVH 498
P +P+ + E+ T++ TD D ++ YT P F++ + GEV
Sbjct: 2048 PPTFLSPKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVR 2107
Query: 499 LLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELT 558
L G LD E+ Y LTV+ D GQ LS S + + V D+ND+ P ++
Sbjct: 2108 LTGELDREEVSNYTLTVVATDKGQPS-----LSSSTEVVVMVLDINDNNPIFAQALYKVE 2162
Query: 559 IYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQ---GAILVHSDLVLGPF 615
I ++ ++ E Y IV GN+ F + GAI V P
Sbjct: 2163 INENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAK-----PL 2217
Query: 616 WPEQPRTYELLICVADAGPSTPHLSTTATIIVHL 649
E+ TY L + D G STP T+ IV L
Sbjct: 2218 DREKTPTYHLTVQATDRG-STPRTDTSTVSIVLL 2250
Score = 72.0 bits (175), Expect = 2e-12
Identities = 112/480 (23%), Positives = 199/480 (41%), Gaps = 33/480 (6%)
Query: 181 FSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIVKVL--PVPSSQVSFLE 238
F+++ G L +Q L + ++ F L I+ + + G + V+ V + +F
Sbjct: 2308 FTLSASGELGV-TQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFAS 2366
Query: 239 QAQNITIPENLAPGSEVVQVQARGVDLRYEILSPV--PSPLFSIGRADGVVRTTTPLELA 296
+A TIPE+ G++V+ V A D + + + F+I + G + T+ L+
Sbjct: 2367 KAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRIIGGNSQFTINPSTGQIITSALLDRE 2426
Query: 297 RTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTV 356
+ + A L +S + +T V VN PPR V+ IP G+
Sbjct: 2427 TKDNYTLVVVCSDAGSPEPLSSSTSVLVT--VTDVNDNPPRFQHHPYVTHIPSPTLPGSF 2484
Query: 357 LNTLTCEDPD-SVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASI 415
+ +T D D + L Y L R+S L ++ + S+
Sbjct: 2485 VFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPL------NGASEVTFSV 2538
Query: 416 LVLDGGQPQMTTEVPVLVMVTPINEFSPACAP-RTFRVQEDAAPHTLLGSVVGTDMDYPH 474
V DGG T V V +F A +TF E+ +L+ ++ G+ +
Sbjct: 2539 HVKDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTITGSSLR--G 2596
Query: 475 DNIEYYTSGGP--TTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSG 532
+ + YY + G TF +D+L+G+V + PLD+E+ + Y + + D G ++
Sbjct: 2597 EPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYE--- 2653
Query: 533 SCTITIEVEDVNDHAP--ECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIV 590
+ I V DVND+AP + +P E+ + + V+ M Q Y IV
Sbjct: 2654 --KLDITVLDVNDNAPIFKEDPFISEILENLSPRKILTVSAMDKDSGPNGQ---LDYEIV 2708
Query: 591 GGNSQNRFILQGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLV 650
GN +N F + A + P E+ Y L I +D G +P ST+ ++++++
Sbjct: 2709 NGNMENSFSINHA--TGEIRSVRPLDREKVSHYVLTIKSSDKG--SPSQSTSVKVMINIL 2764
Score = 70.5 bits (171), Expect = 6e-12
Identities = 101/444 (22%), Positives = 171/444 (38%), Gaps = 25/444 (5%)
Query: 214 QRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD------LRY 267
Q +S +++ V + F +Q + + E PGS V + A D LRY
Sbjct: 453 QARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRY 512
Query: 268 EILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMN 327
I+S F I G+V T + L R + + L + A +QG + L +
Sbjct: 513 SIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIV-LNISARDQGVHPKVSYAQLVVT 571
Query: 328 VQLVNLWPPR-CLPALLVSQIPETAPVGTVLNTLTCEDPD-SVGATLDYKLWFRSSSNPA 385
+ VN P P + E AP GT L L D D T+ + L + ++
Sbjct: 572 LLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQ-EAETDRR 630
Query: 386 SLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPAC 445
S L ++ D F ++ +L D G P ++ + V + IN+ SP
Sbjct: 631 SFRLDPVSGRLSTISSLDREEQAF-YSLLVLATDLGSPPQSSMARINVSLLDINDNSPVF 689
Query: 446 APRTF--RVQEDAAPHTLLGSVVGTDMDY-PHDNIEYYTSGGPTT-FAVDRLSGEVHLLG 501
P + ++E+ + + +V TD D + ++Y S G + F V+ SG +
Sbjct: 690 YPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGDRSRFQVNAQSGVISTRM 749
Query: 502 PLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYA 561
LD E++ Y+L ++ D G Q+PN + +TI V D D+ P ++
Sbjct: 750 ALDREEKTAYQLQIVATDGGNLQSPNQAI-----VTITVLDTQDNPPVFSQVAYSFVVFE 804
Query: 562 PLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPR 621
+ V +S + SY I G+ + F + V L + +
Sbjct: 805 NVALGYHVGSVSASTMDLNSNI--SYLITTGDQKGMFAIN---QVTGQLTTANVIDREEQ 859
Query: 622 TYELLICVADAGPSTPHLSTTATI 645
++ L VA G T T+
Sbjct: 860 SFYQLKVVASGGTVTGDTMVNITV 883
Score = 70.5 bits (171), Expect = 6e-12
Identities = 62/249 (24%), Positives = 113/249 (45%), Gaps = 29/249 (11%)
Query: 414 SILVLDGGQPQ-MTTEVPVLVMVTPINEFSPACAPRTFR--VQEDAAPHTLLGSVVGTDM 470
+++ D G PQ + + V V + IN+ +P ++ + E AA T + V +D+
Sbjct: 1178 TVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDV 1237
Query: 471 DYPHDNIEYYT---SGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPN 527
D ++ + +Y+ FA+D SG+V L+G LDYE Y L + +D G
Sbjct: 1238 DEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIP--- 1294
Query: 528 HHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQI----PQEPQRL 583
L+ +CT+ I++ D ND+ P F + T++ + ++ + ++ +
Sbjct: 1295 --LNSTCTLNIDILDENDNTPS----FPKSTLFVDVLENMRIGELVSSVTATDSDSGDNA 1348
Query: 584 IYSYSIVGGNSQNRFILQ---GAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLS 640
YSI G N+ F + G+I + L E Y+L I D G P S
Sbjct: 1349 DLYYSITGTNNHGTFSISPNTGSIFLAKKLDF-----ETQSLYKLNITAKDQG--RPPRS 1401
Query: 641 TTATIIVHL 649
+T ++++H+
Sbjct: 1402 STMSVVIHV 1410
Score = 70.5 bits (171), Expect = 6e-12
Identities = 101/444 (22%), Positives = 176/444 (39%), Gaps = 30/444 (6%)
Query: 219 QGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD------LRYEILSP 272
Q V V + + + FL+ TI E+ A ++V++V A VD + Y I+
Sbjct: 1193 QATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKG 1252
Query: 273 VPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVN 332
F+I G V L+ T + L ++A + G + ++ L +++ N
Sbjct: 1253 NEERQFAIDSTSGQVTLIGKLDYEATPAYS---LVIQAVDSGTIPLNSTCTLNIDILDEN 1309
Query: 333 LWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSV-GATLDYKLWFRSSSNPASLCLYD 391
P + L + E +G +++++T D DS A L Y + ++ S+
Sbjct: 1310 DNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNT 1369
Query: 392 RVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTF- 450
+ + LD +T + +I D G+P ++ + V++ V N+ P+ P
Sbjct: 1370 GSIFLAKKLDFETQSL---YKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIF 1426
Query: 451 -RVQEDAAPHTLLGSVVGTDMDYPHDNIEYYT----SGGPTTFAVDRLSGEVHLLGPLDY 505
+ E+ T + SV D D + YT F +D + G ++ +D
Sbjct: 1427 KSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDR 1486
Query: 506 EQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGR 565
E L+ LTV D + + +TI V D+ND+ P + +
Sbjct: 1487 EFANLFELTVKANDQAVPIETRRYALKN--VTILVTDLNDNVPMFISQNALAADPSAVIG 1544
Query: 566 SVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFI--LQGAILVHSDLVLGPFWPEQPRTY 623
SV T M+ P E Y I+ G++ + G + V S LV P Q Y
Sbjct: 1545 SVLTTIMAAD-PDEGANGEIEYEIINGDTDTFIVDRYSGDLRVASALV-----PSQ-LIY 1597
Query: 624 ELLICVADAGPSTPHLSTTATIIV 647
L++ D GP +T TII+
Sbjct: 1598 NLIVSATDLGPERRKSTTELTIIL 1621
Score = 67.4 bits (163), Expect = 5e-11
Identities = 110/492 (22%), Positives = 194/492 (39%), Gaps = 41/492 (8%)
Query: 179 GPFSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGM--VIVKVLPVPSSQVSF 236
G F+IN + ++ L + + ++ IS G + G V V V+ V + F
Sbjct: 3135 GIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVF 3194
Query: 237 LEQAQNITIPENLAPGSEVVQVQARGVD------LRYEILSPVPSPLFSIGRADGVVRTT 290
L T+ EN G+ V+ + A D + Y + S S LF I GV+ T
Sbjct: 3195 LSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSS-DSDLFVIDPNTGVITTQ 3253
Query: 291 TPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPET 350
L+ L VKAF + + + ++ N + PR + L +I E
Sbjct: 3254 GFLDFETKQSY---HLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEA 3310
Query: 351 APVGTVLNTLTCEDPD-SVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACF 409
AP GT++ + D D + Y ++ S + + V+ LD +
Sbjct: 3311 APKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREK----- 3365
Query: 410 QHAASILVLDGGQPQM----TTEVPVLVMVTPINEFSPACAPRTFRVQ-EDAAP---HTL 461
+ S+ VL + EV V V V N+ P + VQ + P H
Sbjct: 3366 EERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVT 3424
Query: 462 LGSVVGTDMDYPHDNIEYYTSGGPT--TFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVID 519
S +D Y+ G F+++ +G++ + LD E +Y L+VL +D
Sbjct: 3425 FVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVD 3484
Query: 520 HGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQE 579
G +GS ++ + +ED+ND+ P E+ G V +T S
Sbjct: 3485 SGTPS-----ATGSASLLVTLEDINDNGPMLTVSEGEVMENKRPGTLV-MTLQSTDPDLP 3538
Query: 580 PQRLIYSYSIVG-GNSQNRFILQGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPH 638
P + ++Y ++ G + + F L A ++ + + EQ + L + D+G P
Sbjct: 3539 PNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREID---REQIADFYLSVVTKDSG--VPQ 3593
Query: 639 LSTTATIIVHLV 650
+S+T T+ + ++
Sbjct: 3594 MSSTGTVHITVI 3605
Score = 67.4 bits (163), Expect = 5e-11
Identities = 76/322 (23%), Positives = 135/322 (41%), Gaps = 20/322 (6%)
Query: 236 FLEQAQNITIPENLAPGSEVVQVQARGVDL------RYEILSPVPSPLFSIGRADGVVRT 289
F+ + I E G+ V +V A DL Y I F I + G +
Sbjct: 3298 FVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYV 3357
Query: 290 TTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVS-QIP 348
+ L+ + + L+V A G + + +T+NV +++ P + S QI
Sbjct: 3358 SGILDREKEERVS---LKVLAKNFGSIRGADIDEVTVNVTVLDANDPPIFTLNIYSVQIS 3414
Query: 349 ETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGAC 408
E P+GT + ++ D DS+ + + + S + + + + ++ T + D
Sbjct: 3415 EGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLP 3474
Query: 409 FQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQEDAAPHTLLGSVVGT 468
+ S+L +D G P T +LV + IN+ P V E+ P TL+ ++ T
Sbjct: 3475 IYNL-SVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGEVMENKRPGTLVMTLQST 3533
Query: 469 DMDYPHDN--IEYY--TSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQ 524
D D P + YY ++G T++ +G + +D EQ + L+V+ D G Q
Sbjct: 3534 DPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQIADFYLSVVTKDSGVPQ 3593
Query: 525 NPNHHLSGSCTITIEVEDVNDH 546
+S + T+ I V D ND+
Sbjct: 3594 -----MSSTGTVHITVIDQNDN 3610
Score = 64.3 bits (155), Expect = 4e-10
Identities = 105/475 (22%), Positives = 190/475 (40%), Gaps = 59/475 (12%)
Query: 224 VKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD------LRYEILSPVPSPL 277
+ VL V + F E I ENL+P +++ V A D L YEI++
Sbjct: 2657 ITVLDVNDNAPIFKEDPFISEILENLSP-RKILTVSAMDKDSGPNGQLDYEIVNGNMENS 2715
Query: 278 FSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPR 337
FSI A G +R+ PL+ + S L +K+ ++G S + + +N+ N PR
Sbjct: 2716 FSINHATGEIRSVRPLDREKVSHYV---LTIKSSDKGSPSQSTSVKVMINILDENDNAPR 2772
Query: 338 CLPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVN 397
+ + +PE +P+G + +T D D +G + +S P ++ + ++
Sbjct: 2773 -FSQIFSAHVPENSPLGYTVTRVTTSDED-IGINAISRYSIMDASLPFTINPSTGDIVIS 2830
Query: 398 ATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQEDAA 457
L+ + ++ + D G T V + VT IN+ +P + ++ + D
Sbjct: 2831 RPLNREDTD---RYRIRVSAHDSG---WTVSTDVTIFVTDINDNAPRFSRTSYYL--DCP 2882
Query: 458 PHTLLGS----VVGTDMDY-PHDNIEYYTSGGPTTFAVDRLSGEVHLLGPLDYEQQ---- 508
T +GS V TD D + + Y+ F ++ +GE+ L Y+
Sbjct: 2883 ELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFS 2942
Query: 509 ----RLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLG 564
+ V D G+ L T+TI + D ND+AP+ F + + P+
Sbjct: 2943 NVNINRHSFIVTSSDRGKPS-----LISETTVTINIVDSNDNAPQ----FLKSKYFTPVT 2993
Query: 565 RSVEVTKMSCQIPQEPQRLI-----YSYSIVGGNSQNRFILQ---GAILVHSDLVLGPFW 616
++V+V ++ + Y I N +F L G I V S L+
Sbjct: 2994 KNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLI----- 3048
Query: 617 PEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRAST--VATSTHRTTVPST 669
+ + + + + D G P LS+ AT+ + + T + S T+P +
Sbjct: 3049 SDLNQNFFITVTAKDKG--NPPLSSQATVHITVTEENYHTPEFSQSHMSATIPES 3101
Score = 62.0 bits (149), Expect = 2e-09
Identities = 67/256 (26%), Positives = 111/256 (43%), Gaps = 25/256 (9%)
Query: 410 QHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFR--VQEDAAPHTLLGSVVG 467
Q+ + V D G+P+ + V V V IN+ P ++ V EDA + + V
Sbjct: 215 QYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAA 274
Query: 468 TDMDY-PHDNIEYYTSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNP 526
D D + +I Y T F +D +G + + PLD+E +R Y LTV +D G
Sbjct: 275 ADADEGTNADIRYRLQDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPS-- 332
Query: 527 NHHLSGSCTITIEVEDVNDHAPECE-PPFQELTIYAPLGRSVEV-------TKMSCQIPQ 578
L+G I++ DVND+ P + F + YA + + +V T P
Sbjct: 333 ---LTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPA 389
Query: 579 EPQRLIYSYSIVGGNSQNRFILQGAILVHSDL--VLGPFWPEQPRTYELLICVAD----- 631
+ S I+GGN Q F +Q + + + L V E+ +Y L + V+D
Sbjct: 390 ANGNI--SVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAP 447
Query: 632 AGPSTPHLSTTATIIV 647
G + S+ A++++
Sbjct: 448 PGAAVQARSSVASLVI 463
Score = 60.5 bits (145), Expect = 6e-09
Identities = 104/438 (23%), Positives = 188/438 (42%), Gaps = 54/438 (12%)
Query: 239 QAQNITIPENLAP-GSEVVQVQA---RGVD--LRYEILS-----PVPSPLFSIGRADGVV 287
Q + ITI + P G+ V+ ++A RG + + Y I+S LF+IGR G++
Sbjct: 1631 QPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGII 1690
Query: 288 RTTTPLELARTSGTAVSRLQVKAFEQGQLW-ASAKLNLTMNVQLVNLWPPRCLPALLVSQ 346
+T L+ R G + + V A E+ + + + + + +Q +N PP +L
Sbjct: 1691 QTAAILD--REQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLT 1748
Query: 347 IPETAPVGTVLNTLTCEDPD-SVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTP 405
+ E G+ + LT D D A + Y + S S + ++ AT D
Sbjct: 1749 VEENIGDGSKIMQLTAMDADEGANALVTYTI---ISGADDSFRIDPESGDLIATRRLDRE 1805
Query: 406 GACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACA--PRTFRVQEDAAPHTLLG 463
+ + L++ ++++ + + V+ +N+ +P + +F + ED P +L+
Sbjct: 1806 ----RRSKYSLLVRADDGLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVA 1861
Query: 464 SVVGTDMDY-PHDNIEYYTSGGPT--TFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDH 520
+++ TD D + I Y + F ++ ++G +L LDYE Q+ Y LTV D
Sbjct: 1862 AILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDG 1921
Query: 521 GQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYA-------PLGRSVEVTKMS 573
G + + + DVND+ PP L Y+ P+G +V V ++
Sbjct: 1922 GGQFT-------TIRVYFNILDVNDN-----PPIFSLNSYSTSLMENLPVGSTVLVFNVT 1969
Query: 574 CQIPQEPQRLIYSYSIVGGNSQNRFIL-QGAILVHSDLVLGPFWPEQPRTYELLICVADA 632
+L +YSI G+S +F + + +L VL E Y L++ V D
Sbjct: 1970 DADDGINSQL--TYSIASGDSLGQFTVDKNGVL----KVLKALDRESQSFYNLVVQVHDL 2023
Query: 633 GPSTPHLSTTATIIVHLV 650
P P T+T V ++
Sbjct: 2024 -PQIPASRFTSTAQVSII 2040
Score = 59.3 bits (142), Expect = 1e-08
Identities = 105/461 (22%), Positives = 185/461 (40%), Gaps = 43/461 (9%)
Query: 203 VFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARG 262
V+ ++ S +F + Q + V + + + + F ++T+ EN+ GS+++Q+ A
Sbjct: 1709 VYAIEKSTAFPRTQRAE--VEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMD 1766
Query: 263 VD------LRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQL 316
D + Y I+S F I G + T L+ R S + L V+A + Q
Sbjct: 1767 ADEGANALVTYTIISGADDS-FRIDPESGDLIATRRLDRERRSKYS---LLVRADDGLQ- 1821
Query: 317 WASAKLNLTMNVQLVNLWPPRCLPALLVSQIPE-TAPVGTVLNTLTCEDPDSVGATLDYK 375
S+ + + + V VN P+ + IPE T P V L +D V + Y
Sbjct: 1822 --SSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYI 1879
Query: 376 LWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMV 435
+ L V + LD + Q+ + + G Q TT + V +
Sbjct: 1880 VNEDDEDGIFFLNPITGVFNLTRLLDYEVQ----QYYILTVRAEDGGGQFTT-IRVYFNI 1934
Query: 436 TPINEFSPACAPRTFR---VQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPT--TFAV 490
+N+ P + ++ ++ T+L V D + + Y + G + F V
Sbjct: 1935 LDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTV 1994
Query: 491 DRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPEC 550
D+ +G + +L LD E Q Y L V V H Q P + + ++I + DVND+ P
Sbjct: 1995 DK-NGVLKVLKALDRESQSFYNLVVQV--HDLPQIPASRFTSTAQVSIILLDVNDNPPTF 2051
Query: 551 EPPFQELTIYAPLGRSVE--VTKMSCQIPQEPQRLIYSYSIVG--GNSQNRFILQGAILV 606
P +LT Y P ++ V K P Y+++ GN + + G + +
Sbjct: 2052 LSP--KLT-YIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRL 2108
Query: 607 HSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIV 647
+L E+ Y L + D G P LS++ ++V
Sbjct: 2109 TGELD-----REEVSNYTLTVVATDKG--QPSLSSSTEVVV 2142
Score = 52.0 bits (123), Expect = 2e-06
Identities = 129/540 (23%), Positives = 194/540 (35%), Gaps = 92/540 (17%)
Query: 168 IISAQDLPHFPGPFSINEQG---WLQAPSQGLLG-QAQKVFQLQISVSFGQRQSCQG--M 221
II + F ++N G +L S+G L + +QL + V +G
Sbjct: 176 IIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQ 235
Query: 222 VIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQAR------GVDLRYEILSPVPS 275
V V V + + F +PE+ GS V+QV A D+RY L +
Sbjct: 236 VNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYR-LQDEGT 294
Query: 276 PLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWP 335
P F + G++ PL+ + L V+A ++G + + + + VN
Sbjct: 295 P-FQMDPETGLITVREPLDFEARRQYS---LTVQAMDRGVPSLTGRAEALIQLLDVNDND 350
Query: 336 P----RCLPALL-VSQIPETAPVGTVLNTLTCEDPDS-----------VGATLDYKLWFR 379
P R PA + + E A VGTV+ LT D DS +G +
Sbjct: 351 PVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQ 410
Query: 380 SSSNP-------ASLCLYDRVLEVNATLDCD-----TPGACFQHAASILVLDGGQPQMTT 427
SS P AS +R+ N T+ PGA Q +S+ L
Sbjct: 411 SSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASL--------- 461
Query: 428 EVPVLVMVTPINEFSPACAPRTFRV--QEDAAPHTLLGSVVGTDMDYP-HDNIEY--YTS 482
++ V IN+ P + + +RV E+A P + + + TD D + N+ Y +
Sbjct: 462 ----VIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSG 517
Query: 483 GGPTTFAVDRLSGEVHL--LGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEV 540
G F + SG V G LD E L + D G H + + +
Sbjct: 518 NGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGV-----HPKVSYAQLVVTL 572
Query: 541 EDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFIL 600
DVND P P G V V + + E L + +G N RF L
Sbjct: 573 LDVNDEKP---------VFSQPEGYDVSVVE-NAPTGTELLMLRATDGDLGDNGTVRFSL 622
Query: 601 QGAILVHSDLVLGP----------FWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLV 650
Q A L P E+ Y LL+ D G +P S+ A I V L+
Sbjct: 623 QEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLG--SPPQSSMARINVSLL 680
>gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precursor
[Homo sapiens]
Length = 1007
Score = 101 bits (251), Expect = 3e-21
Identities = 140/604 (23%), Positives = 243/604 (40%), Gaps = 74/604 (12%)
Query: 139 IQVPETVTPGARLYTLLLPGLELHGAQMSIISAQDLPHFP---GPFSINEQGWLQAPSQG 195
+QV E+V PGAR + ++ + HF P N + +G
Sbjct: 155 LQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKPLQENSKVLELVLRKG 214
Query: 196 LLGQAQKVFQLQISVSFG--QRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGS 253
L + + L ++ G +S + V+VL + +F + + + E+ PG+
Sbjct: 215 LDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLREDSPPGT 274
Query: 254 EVVQVQARGVD------LRYEILSPVPS---PLFSIGRADGVVRTTTPLELARTSGTAVS 304
VV++ A D LRY + S LFSI + G VR L+ S
Sbjct: 275 LVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSY--- 331
Query: 305 RLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCED 364
++ V+A ++G + + + +++ VN P + L S +PE A T++ L+ D
Sbjct: 332 QIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVND 391
Query: 365 PDS-----VGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLD 419
DS V L+ L FR + S L V+ LD + + ++ D
Sbjct: 392 QDSGPNRKVSLGLEATLPFRLNGFGNSY-----TLVVSGPLDRERVAV---YNITVTATD 443
Query: 420 GGQPQMTTEVPVLVMVTPINEFSPACAPRTFR--VQEDAAPHTLLGSVVGTDMD------ 471
GG PQ+T+ + V ++ IN+ P+ ++ +QE+ P LL +V TD D
Sbjct: 444 GGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAE 503
Query: 472 YPHDNIEYYTSGGPTT--FAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHH 529
+ +E G P T +++ SG ++ + DYE+ R + +TV D G
Sbjct: 504 VTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPP----- 558
Query: 530 LSGSCTITIEVEDVNDHAPECEPP--------FQELTIYAPLGRSVEVTKMSCQIPQEPQ 581
LS + T + V D+NDHAP P F+ + AP G VTK+ Q
Sbjct: 559 LSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAG--YLVTKVIAMDSDSGQ 616
Query: 582 RLIYSYSIVGGNSQNRFILQGAILVHSDLV--LGPFWPEQPRTYELLICVADAGPSTPHL 639
Y + + + F ++ +H+ + E T+ L + V D G P L
Sbjct: 617 NAWLFYHLAQTSDLDLFKVE----LHTGEIRTTRKMGDESGSTFNLTVVVRDNG--EPSL 670
Query: 640 STTATIIVHLVPRRASTVATSTHRTTVPSTMTPMLVTDTEAFWQPQPWFVVVLTATGALL 699
S + I V +V R + + + P T + + + + ++ L+ +
Sbjct: 671 SASVAITVAVVDRVSKILPDTQRHVKSPRTYSEITL-----------YLIIALSTVSFIF 719
Query: 700 LLAL 703
LL +
Sbjct: 720 LLTI 723
Score = 32.7 bits (73), Expect = 1.3
Identities = 56/249 (22%), Positives = 95/249 (38%), Gaps = 34/249 (13%)
Query: 443 PACAPRTFRVQEDAAPHTLLGSV---VGTDMDYPHDN---IEYYTSGGPTTFAVDRLSGE 496
PA + + V E+ AP L+G+V +G ++ I + + P +D SG
Sbjct: 39 PAASQLRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRINHLGAPSPRYLELDLTSGA 98
Query: 497 VHLLGPLDYE---QQR---LYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPEC 550
+ + +D E +QR L L VL H+ + +E+ D+ND++P
Sbjct: 99 LFVNERIDREALCEQRPRCLLSLEVLA----------HNPVAVSAVEVEILDINDNSPRF 148
Query: 551 EPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSDL 610
P +L + + S Q P + +Y + + F L L +
Sbjct: 149 PRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYEL---SPSEHFELDLKPLQENSK 205
Query: 611 VL-----GPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVA--TSTHR 663
VL EQ + L++ D G P S TA I V ++ ++ A ST+R
Sbjct: 206 VLELVLRKGLDREQAALHHLVLTAVDGG--IPARSGTAQISVRVLDTNDNSPAFDQSTYR 263
Query: 664 TTVPSTMTP 672
+ P
Sbjct: 264 VQLREDSPP 272
>gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precursor
[Homo sapiens]
Length = 884
Score = 101 bits (251), Expect = 3e-21
Identities = 140/604 (23%), Positives = 243/604 (40%), Gaps = 74/604 (12%)
Query: 139 IQVPETVTPGARLYTLLLPGLELHGAQMSIISAQDLPHFP---GPFSINEQGWLQAPSQG 195
+QV E+V PGAR + ++ + HF P N + +G
Sbjct: 155 LQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKPLQENSKVLELVLRKG 214
Query: 196 LLGQAQKVFQLQISVSFG--QRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGS 253
L + + L ++ G +S + V+VL + +F + + + E+ PG+
Sbjct: 215 LDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLREDSPPGT 274
Query: 254 EVVQVQARGVD------LRYEILSPVPS---PLFSIGRADGVVRTTTPLELARTSGTAVS 304
VV++ A D LRY + S LFSI + G VR L+ S
Sbjct: 275 LVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSY--- 331
Query: 305 RLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCED 364
++ V+A ++G + + + +++ VN P + L S +PE A T++ L+ D
Sbjct: 332 QIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVND 391
Query: 365 PDS-----VGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLD 419
DS V L+ L FR + S L V+ LD + + ++ D
Sbjct: 392 QDSGPNRKVSLGLEATLPFRLNGFGNSY-----TLVVSGPLDRERVAV---YNITVTATD 443
Query: 420 GGQPQMTTEVPVLVMVTPINEFSPACAPRTFR--VQEDAAPHTLLGSVVGTDMD------ 471
GG PQ+T+ + V ++ IN+ P+ ++ +QE+ P LL +V TD D
Sbjct: 444 GGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAE 503
Query: 472 YPHDNIEYYTSGGPTT--FAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHH 529
+ +E G P T +++ SG ++ + DYE+ R + +TV D G
Sbjct: 504 VTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPP----- 558
Query: 530 LSGSCTITIEVEDVNDHAPECEPP--------FQELTIYAPLGRSVEVTKMSCQIPQEPQ 581
LS + T + V D+NDHAP P F+ + AP G VTK+ Q
Sbjct: 559 LSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAG--YLVTKVIAMDSDSGQ 616
Query: 582 RLIYSYSIVGGNSQNRFILQGAILVHSDLV--LGPFWPEQPRTYELLICVADAGPSTPHL 639
Y + + + F ++ +H+ + E T+ L + V D G P L
Sbjct: 617 NAWLFYHLAQTSDLDLFKVE----LHTGEIRTTRKMGDESGSTFNLTVVVRDNG--EPSL 670
Query: 640 STTATIIVHLVPRRASTVATSTHRTTVPSTMTPMLVTDTEAFWQPQPWFVVVLTATGALL 699
S + I V +V R + + + P T + + + + ++ L+ +
Sbjct: 671 SASVAITVAVVDRVSKILPDTQRHVKSPRTYSEITL-----------YLIIALSTVSFIF 719
Query: 700 LLAL 703
LL +
Sbjct: 720 LLTI 723
Score = 32.7 bits (73), Expect = 1.3
Identities = 56/249 (22%), Positives = 95/249 (38%), Gaps = 34/249 (13%)
Query: 443 PACAPRTFRVQEDAAPHTLLGSV---VGTDMDYPHDN---IEYYTSGGPTTFAVDRLSGE 496
PA + + V E+ AP L+G+V +G ++ I + + P +D SG
Sbjct: 39 PAASQLRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRINHLGAPSPRYLELDLTSGA 98
Query: 497 VHLLGPLDYE---QQR---LYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPEC 550
+ + +D E +QR L L VL H+ + +E+ D+ND++P
Sbjct: 99 LFVNERIDREALCEQRPRCLLSLEVLA----------HNPVAVSAVEVEILDINDNSPRF 148
Query: 551 EPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSDL 610
P +L + + S Q P + +Y + + F L L +
Sbjct: 149 PRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYEL---SPSEHFELDLKPLQENSK 205
Query: 611 VL-----GPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVA--TSTHR 663
VL EQ + L++ D G P S TA I V ++ ++ A ST+R
Sbjct: 206 VLELVLRKGLDREQAALHHLVLTAVDGG--IPARSGTAQISVRVLDTNDNSPAFDQSTYR 263
Query: 664 TTVPSTMTP 672
+ P
Sbjct: 264 VQLREDSPP 272
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 99.0 bits (245), Expect = 2e-20
Identities = 130/530 (24%), Positives = 220/530 (41%), Gaps = 45/530 (8%)
Query: 141 VPETVTPGARLYTLLLPGLELHGAQMSIISAQDLPHFPGPFSINEQGWLQAPSQGLLGQA 200
+PE V PG + + ++ + I+ L F +N S L +
Sbjct: 3032 IPEDVLPGKLIMQISATDADIRSN--AEITYTLLGSGAEKFKLNPDTGELKTSTPLDREE 3089
Query: 201 QKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQA 260
Q V+ L + + G + CQ +++ + V + F IT+ EN PG+ + +VQA
Sbjct: 3090 QAVYHLLVRATDGGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQA 3149
Query: 261 RGVD------LRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQG 314
D + Y ++ FSI G+++ PL+ AV L +KA +QG
Sbjct: 3150 TDADAGLNRKILYSLIDSADGQ-FSINELSGIIQLEKPLD---RELQAVYTLSLKAVDQG 3205
Query: 315 -QLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGT-VLNTLTCEDPDSVGATL 372
+A + ++V +N PP + + E VGT VL A +
Sbjct: 3206 LPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEI 3265
Query: 373 DYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVL 432
Y + + S+ + + LD + + ++ ++ DGG P ++ V
Sbjct: 3266 TYSIISGNEHGKFSIDSKTGAVFIIENLDYE---SSHEYYLTVEATDGGTPSLSDVATVN 3322
Query: 433 VMVTPINEFSPACAPRTFR--VQEDAAPHTLLGSVVGTDMDYPHDNIEYYT---SGGPTT 487
V VT IN+ +P + T+ + EDA + +V+ D D P ++ +Y+ ++
Sbjct: 3323 VNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSS 3382
Query: 488 FAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHA 547
F +D + GEV + LD E Y LTV D+G N + T+ I+V DVND+A
Sbjct: 3383 FTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVN-----TTTVNIDVSDVNDNA 3437
Query: 548 PECEPPFQELTIY--APLGRSV---EVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFIL-- 600
P + I P+G SV VT P + ++IV GN + F +
Sbjct: 3438 PVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPP----FFFTIVTGNDEKAFEVNP 3493
Query: 601 QGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLV 650
QG +L S + ++ Y L + VAD G P LS+ I + ++
Sbjct: 3494 QGVLLTSSAIK-----RKEKDHYLLQVKVADNG--KPQLSSLTYIDIRVI 3536
Score = 89.7 bits (221), Expect = 9e-18
Identities = 121/501 (24%), Positives = 198/501 (39%), Gaps = 46/501 (9%)
Query: 217 SCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVDLR------YEIL 270
S + +V VKVL + + + TIPE++ PG ++Q+ A D+R Y +L
Sbjct: 3004 SSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLL 3063
Query: 271 SPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQL 330
+ F + G ++T+TPL+ AV L V+A + G + A + LT+ +
Sbjct: 3064 GS-GAEKFKLNPDTGELKTSTPLD---REEQAVYHLLVRATDGGGRFCQASIVLTL--ED 3117
Query: 331 VNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFR---SSSNPASL 387
VN P + E GT+L + D D A L+ K+ + S+ S+
Sbjct: 3118 VNDNAPEFSADPYAITVFENTEPGTLLTRVQATDAD---AGLNRKILYSLIDSADGQFSI 3174
Query: 388 CLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQP-QMTTEVPVLVMVTPINEFSPACA 446
++++ LD + + S+ +D G P ++T V+V V IN+ P
Sbjct: 3175 NELSGIIQLEKPLDRELQAV---YTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFE 3231
Query: 447 PRTF--RVQEDAAPHTLLGSVVGTDMDY-PHDNIEYYTSGGPT--TFAVDRLSGEVHLLG 501
R + V ED T + V D + I Y G F++D +G V ++
Sbjct: 3232 YREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIE 3291
Query: 502 PLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYA 561
LDYE Y LTV D G LS T+ + V D+ND+ P I
Sbjct: 3292 NLDYESSHEYYLTVEATDGGTPS-----LSDVATVNVNVTDINDNTPVFSQDTYTTVISE 3346
Query: 562 PLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFIL---QGAILVHSDLVLGPFWPE 618
V + P YSI+ GN + F + +G + V L E
Sbjct: 3347 DAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLD-----RE 3401
Query: 619 QPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTHRTTVPS------TMTP 672
Y L + +D G +TT I V V A + + + ++
Sbjct: 3402 TISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQ 3461
Query: 673 MLVTDTEAFWQPQPWFVVVLT 693
++VTD ++ P+F ++T
Sbjct: 3462 LVVTDEDSSHNGPPFFFTIVT 3482
Score = 85.9 bits (211), Expect = 1e-16
Identities = 119/449 (26%), Positives = 181/449 (40%), Gaps = 44/449 (9%)
Query: 224 VKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVDL------RYEILSPVPSPL 277
V V+ + FL+++ + + E+ SE++QV+A DL Y I++ +
Sbjct: 810 VVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT-- 867
Query: 278 FSIGRADGVVRTTTPL--ELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWP 335
FSI GVV PL EL + +A E+ QL+++ + +++ + VN P
Sbjct: 868 FSIDSVTGVVNIARPLDRELQHEHSLKIEARD-QAREEPQLFSTVVVKVSL--EDVNDNP 924
Query: 336 PRCLPALLVSQIPETAPVGTVLNTLTCEDPD-SVGATLDYKLWFRSSSNPASLCLYDRVL 394
P +P ++ E P GTV+ L DPD + Y L N + +
Sbjct: 925 PTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN-FDVDKLSGAV 983
Query: 395 EVNATLDCDTPGACFQHAASILVLDGGQP-QMTTEVPVLVMVTPINE------FSPACAP 447
+ LD + + ++ D G+P +++ V V V +NE FS
Sbjct: 984 RIVQQLDFEKKQV---YNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
Query: 448 RTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYT---SGGPTTFAVDRLSGEVHLLGPLD 504
T V+EDA +L+ +V D D D Y+ G F + +G + LD
Sbjct: 1041 GT--VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLD 1098
Query: 505 YEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLG 564
E Y LTV D G LS I IEVEDVND+AP+ P I
Sbjct: 1099 RESTSHYWLTVFATDQGVVP-----LSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSP 1153
Query: 565 RSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQ---GAILVHSDLVLGPFWPEQPR 621
+ V V ++ P Y I GN Q F + G I S EQ
Sbjct: 1154 KDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTS----RKLDREQQD 1209
Query: 622 TYELLICVADAGPSTPHLSTTATIIVHLV 650
+ L + V D G +P ST A +IV ++
Sbjct: 1210 EHILEVTVTDNG--SPPKSTIARVIVKIL 1236
Score = 70.1 bits (170), Expect = 8e-12
Identities = 93/412 (22%), Positives = 164/412 (39%), Gaps = 44/412 (10%)
Query: 222 VIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQA------RGVDLRYEILSPVPS 275
++V V F + + E+ A GS V+QV A + ++ Y I S
Sbjct: 1548 IVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIG 1607
Query: 276 PLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWP 335
F I G ++T L+ S A L VKA ++G S ++ + V + +
Sbjct: 1608 NSFMIDPVLGSIKTAKELD---RSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNAS 1664
Query: 336 PRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLE 395
P+ ++ ET +G+ + +T SV Y++ ++ + + + +
Sbjct: 1665 PKFTSKEYSVELSETVSIGSFVGMVTAHSQSSVV----YEIKDGNTGDAFDINPHSGTII 1720
Query: 396 VNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPAC--APRTFRVQ 453
LD +T ++++ ++T VLV + N+ +P A T +
Sbjct: 1721 TQKALDFET-----LPIYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLIS 1775
Query: 454 EDAAPHTLLGSVVGTDMDYP-----------HDNIEYYTSGGP---TTFAVDRLSGEVHL 499
E A+ + SVV TD + P + + Y P T FA+D +G +H
Sbjct: 1776 ESAS----INSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHT 1831
Query: 500 LGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTI 559
+ LDYE+ ++ TV V D G P + +T+ V D+ND P P E ++
Sbjct: 1832 VLSLDYEETSIFHFTVQVHDMG---TPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASL 1888
Query: 560 YAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQ---GAILVHS 608
P + V+V ++ YSI GN +F + GA+ V +
Sbjct: 1889 LLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQN 1940
Score = 67.4 bits (163), Expect = 5e-11
Identities = 64/203 (31%), Positives = 93/203 (45%), Gaps = 21/203 (10%)
Query: 428 EVPVLVMVTPINEFSPACAPRTFRV--QEDAAPHTLLGSVVGTDMDY-PHDNIEYYTSGG 484
EV V ++V IN+ P A +++ V E + T + V TD D P+ I Y G
Sbjct: 2266 EVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGN 2325
Query: 485 PTT----FAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEV 540
+ F VD +G + LL LDYEQ R + + V +D G LS +T++V
Sbjct: 2326 HSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPT-----LSSDVIVTVDV 2380
Query: 541 EDVNDHAPECEPPFQELTI--YAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRF 598
D+ND+ P E E I +AP G V K + +L YSI+ GN F
Sbjct: 2381 TDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKL--QYSILSGNDHKHF 2438
Query: 599 ILQGA--ILVHSDL---VLGPFW 616
++ A I+ S+L L PF+
Sbjct: 2439 VIDSATGIITLSNLHRHALKPFY 2461
Score = 64.7 bits (156), Expect = 3e-10
Identities = 77/338 (22%), Positives = 137/338 (40%), Gaps = 27/338 (7%)
Query: 222 VIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVDLRYEIL-------SPVP 274
V +KV+ + F + IPE+ AP +E++Q+ A D + +++ P+
Sbjct: 1442 VFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLS 1501
Query: 275 SPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLW 334
F + A G + T+ L+ L V +Q + +NV N
Sbjct: 1502 LKKFRLDPATGSLYTSEKLD---HEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDH 1558
Query: 335 PPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVL 394
P + ++ E+A VG+V+ +T D D G + L+ S N + + D VL
Sbjct: 1559 APWFTASSYKGRVYESAAVGSVVLQVTALDKDK-GKNAEV-LYSIESGNIGNSFMIDPVL 1616
Query: 395 -EVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQ 453
+ + D ++ + D G P M+ V + VT + SP + + V
Sbjct: 1617 GSIKTAKELDRSNQA-EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSV- 1674
Query: 454 EDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPT--TFAVDRLSGEVHLLGPLDYEQQRLY 511
+ + +GS VG + ++ Y G T F ++ SG + LD+E +Y
Sbjct: 1675 -ELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIY 1733
Query: 512 RLTVLVIDHGQDQNPN-HHLSGSCTITIEVEDVNDHAP 548
L + Q N LS + T+ + ++D ND+AP
Sbjct: 1734 TLII--------QGTNMAGLSTNTTVLVHLQDENDNAP 1763
Score = 61.6 bits (148), Expect = 3e-09
Identities = 64/228 (28%), Positives = 93/228 (40%), Gaps = 18/228 (7%)
Query: 431 VLVMVTPINEFSPACAPRTFRVQ--EDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPTT- 487
V V V N+ P +P ++ V E+ A T + V TD D + YY+ T
Sbjct: 135 VRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDM 194
Query: 488 FAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHA 547
FA+ SG + L G LDY + +LY + +L D G + +S +T+ +E N
Sbjct: 195 FAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQAN--- 251
Query: 548 PECEPPFQELTIY-APLGRS---VEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRF----I 599
EC P +T+ + L R VT C Q I S SIV G+ +F
Sbjct: 252 -ECAPVITAVTLSPSELDRDPAYAIVTVDDCD--QGANGDIASLSIVAGDLLQQFRTVRS 308
Query: 600 LQGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIV 647
G+ + G W P Y L + D G + P S+ I V
Sbjct: 309 FPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKG-TPPQFSSVKVIHV 355
Score = 58.2 bits (139), Expect = 3e-08
Identities = 78/350 (22%), Positives = 139/350 (39%), Gaps = 18/350 (5%)
Query: 181 FSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQA 240
F I G + Q L K + + + G + VIV + + + F +
Sbjct: 2127 FQIGPLGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVMNKAMPVFEKPF 2186
Query: 241 QNITIPENLAPGSEVVQVQAR---GVDLRYEILSPVPSPLFSIGRADGVVRTTTPLELAR 297
+ I E++ S VV VQA G+ + Y I P F+I GV+ PL+
Sbjct: 2187 YSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDF-- 2244
Query: 298 TSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVL 357
+L ++A + A A++ + + V +N PP + E + +GT +
Sbjct: 2245 -EAHPAYKLSIRATDS-LTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSV 2302
Query: 358 NTLTCEDPDSV-GATLDYKLWFRSSSNPASLCLYDR--VLEVNATLDCDTPGACFQHAAS 414
+ D DS + Y+++ S + + ++ + TLD + QH
Sbjct: 2303 VQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSR---QHTIF 2359
Query: 415 ILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTF--RVQEDAAPHTLLGSVVGTDMDY 472
+ +DGG P ++++V V V VT +N+ P + + R+ E A + V D D
Sbjct: 2360 VRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADS 2419
Query: 473 PH-DNIEYYTSGG--PTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVID 519
D ++Y G F +D +G + L + + Y L + V D
Sbjct: 2420 SDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSD 2469
Score = 53.1 bits (126), Expect = 1e-06
Identities = 102/438 (23%), Positives = 167/438 (38%), Gaps = 47/438 (10%)
Query: 228 PVPSSQ-VSFLEQAQNITIPEN--LAPGSEVVQVQARGVDLRYEILSPVPSPLFSIGRAD 284
P PS + +SF E T+ E+ +A V+ V+ G+ L ++I F + +
Sbjct: 1349 PKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGT 1408
Query: 285 GVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLV 344
G + PL+ + S L V+A + + + + V N P+ +
Sbjct: 1409 GTIIVAKPLDAEQKSNY---NLTVEATDGT---TTILTQVFIKVIDTNDHRPQFSTSKYE 1462
Query: 345 SQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLY-----DRVLEVNAT 399
IPE T + ++ D D + Y L +SS +P SL + L +
Sbjct: 1463 VVIPEDTAPETEILQISAVDQDEKNKLI-YTL--QSSRDPLSLKKFRLDPATGSLYTSEK 1519
Query: 400 LDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTF--RVQEDAA 457
LD + A QH +++V D P ++V V+ N+ +P ++ RV E AA
Sbjct: 1520 LDHE---AVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAA 1576
Query: 458 PHTLLGSVVGTDMDYPHDNIEYYT--SGG-PTTFAVDRLSGEVHLLGPLDYEQQRLYRLT 514
+++ V D D + Y+ SG +F +D + G + LD Q Y L
Sbjct: 1577 VGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636
Query: 515 VLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSC 574
V D G +P S I + + D P F L +V +
Sbjct: 1637 VKATDKG---SPPMSEITSVRIFVTIAD------NASPKFTSKEYSVELSETVSIGSFVG 1687
Query: 575 QIPQEPQRLIYSYSIVGGNSQNRFILQ---GAILVHSDLVLGPFWPEQPRTYELLICVAD 631
+ Q + Y I GN+ + F + G I+ L E Y L+I
Sbjct: 1688 MVTAHSQSSVV-YEIKDGNTGDAFDINPHSGTIITQKALDF-----ETLPIYTLII---- 1737
Query: 632 AGPSTPHLSTTATIIVHL 649
G + LST T++VHL
Sbjct: 1738 QGTNMAGLSTNTTVLVHL 1755
Score = 53.1 bits (126), Expect = 1e-06
Identities = 82/371 (22%), Positives = 150/371 (40%), Gaps = 35/371 (9%)
Query: 236 FLEQAQNITIPENLAPGSEVVQVQARGVD------LRYEILS--PVPSPLFSIGRADGVV 287
F +Q+ +T+ E G+ VVQV+A D + Y++ F + + G++
Sbjct: 2283 FAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLI 2342
Query: 288 RTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQI 347
L+ ++ + V+A + G S+ + +T++V +N PP + ++I
Sbjct: 2343 SLLRTLDYEQSRQHTIF---VRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARI 2399
Query: 348 PETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGA 407
E AP G + + D DS + +D + S N + D + +
Sbjct: 2400 SEHAPHGHFVTCVKAYDADS--SDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHAL 2457
Query: 408 CFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQ--EDAAPHTLLGSV 465
++ ++ V DG + V V V N SPA + V+ E+A HTL+ V
Sbjct: 2458 KPFYSLNLSVSDG---VFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEV 2514
Query: 466 VGTDMDYP-HDNIEYYTSGGPTTFAVDRL----SGEVHLLGPLDYEQ--QRLYRLTVLVI 518
TD D + ++ Y+ FA DR G++ L LD E +++ + ++
Sbjct: 2515 KTTDGDSGIYGHVTYHIVND---FAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAK 2571
Query: 519 DHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQ 578
D G CT+ + + D ND+AP+ E+ I + + V K+
Sbjct: 2572 DAGGKV-------AFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDAD 2624
Query: 579 EPQRLIYSYSI 589
E +Y+I
Sbjct: 2625 EGSNADITYAI 2635
Score = 51.6 bits (122), Expect = 3e-06
Identities = 87/367 (23%), Positives = 139/367 (37%), Gaps = 47/367 (12%)
Query: 245 IPENLAPGSEVVQVQARGVD------LRYEILSPVPSPLFSIGRADGVVRTTTPLELART 298
I EN VVQ++A D L Y+I S P FSI G++ TTT +L R
Sbjct: 1148 IMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLI-TTTSRKLDRE 1206
Query: 299 SGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPE--------T 350
L+V + G S + + + N P+ L ++PE
Sbjct: 1207 QQDE-HILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERN 1265
Query: 351 APVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQ 410
A + + + + + A + Y + N + V ++ G
Sbjct: 1266 ARREPLYHVIATDKDEGPNAEISYSI---EDGNEHGKFFIEPKTGVVSSKRFSAAGE--Y 1320
Query: 411 HAASILVLDGGQPQM--TTEVPVLVMVTPINEFSPACAPR---TFRVQEDAAPHTLLGSV 465
SI +D G+PQ TT + + + P P TF V E ++G +
Sbjct: 1321 DILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVI 1380
Query: 466 VGTDMDYPHDNIEYYTSGG--PTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQD 523
++ P + + +GG + F VD+ +G + + PLD EQ+ Y LTV D
Sbjct: 1381 ---SVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATD---- 1433
Query: 524 QNPNHHLSGSCTIT----IEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQE 579
G+ TI I+V D NDH P+ E+ I E+ ++S E
Sbjct: 1434 --------GTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE 1485
Query: 580 PQRLIYS 586
+LIY+
Sbjct: 1486 KNKLIYT 1492
Score = 47.8 bits (112), Expect = 4e-05
Identities = 118/532 (22%), Positives = 195/532 (36%), Gaps = 88/532 (16%)
Query: 181 FSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQA 240
FS+N L + + + Q F+L+++ S + V+VKVL S+ F + A
Sbjct: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTS---DRKASTKVLVKVLGANSNPPEFTQTA 467
Query: 241 QNITIPENLAPGSEVVQVQARGVD------LRYEI--LSPVPSPLFSIGRADGVVRTTTP 292
EN+ G+ V+ + A D + Y I L+ VP F+I G V T+
Sbjct: 468 YKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVP---FAIDHFTGAVSTSEN 524
Query: 293 LELARTSGTAVSRLQVKAFEQGQLW-ASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETA 351
L+ V L+++A + G + ++ T+ + +N P IP
Sbjct: 525 LDYELM--PRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDL 582
Query: 352 PVGTVLNTLTCEDPDSV---------GATLDYKLWFRSSSNPASLCL------------- 389
VG + T++ D D + G LD+ F + N L L
Sbjct: 583 GVGEQITTVSAIDADELQLVQYQIEAGNELDF---FSLNPNSGVLSLKRSLMDGLGAKVS 639
Query: 390 -------------YDRVLEVNAT---------LDCDTPGACFQHAASILVLDGGQPQMTT 427
+ L +N T L C+ G A +L + Q
Sbjct: 640 FHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEV 699
Query: 428 EVPVLVMVTPINEFSP---ACAPRTFRVQEDAAPHTLLGSVVGTDMDYP-HDNIEYYTSG 483
E + +N P + P +V+E+ + + + TD+D + + Y SG
Sbjct: 700 E-DIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSG 758
Query: 484 G--PTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVE 541
G + F +D +G + +L PLD E Y L + V D G Q L + + V
Sbjct: 759 GNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRL-----LHVVVV 813
Query: 542 DVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRL----IYSYSIVGGNSQNR 597
D ND+ PE F + + + + EV Q+ + L +YSIV +
Sbjct: 814 DANDNPPE----FLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIV--TDTDT 867
Query: 598 FILQGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHL 649
F + V + + P E + L I D P L +T + V L
Sbjct: 868 FSIDSVTGVVN--IARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSL 917
Score = 46.6 bits (109), Expect = 9e-05
Identities = 103/485 (21%), Positives = 186/485 (38%), Gaps = 50/485 (10%)
Query: 243 ITIPENLAPGSEVVQVQAR------GVDLRYEILSPVPSPL--FSIGRADGVVRTTTPLE 294
+ I + A G+ VV+V A D+ Y I + S I + GV+ T L
Sbjct: 2603 VNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLI 2662
Query: 295 LARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVG 354
V+A + G + + + + + + P+ + E P+G
Sbjct: 2663 GLENE---FFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIG 2719
Query: 355 TVLNTLTCEDPDSVGATLDYKLWFRSS--SNPASLCLYDRV---LEVNATLDCDTPGACF 409
T ++ + E T+ Y L ++ SN + DR L++ +LD +T
Sbjct: 2720 TEIDLIRAEH----SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTK--- 2772
Query: 410 QHAASILV-LDGGQPQMTTEVPVLVMVTPINEFSPA--CAPRTFRVQEDAAPHTLLGSVV 466
+ SIL +M V V + V N+ SP +P + E+ + + +
Sbjct: 2773 WYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIR 2832
Query: 467 GTDMDYPHDNIEYYTSGGPTT------FAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDH 520
+D D + Y+ + FA++ +G + L LD+E++ Y++ V+ DH
Sbjct: 2833 ASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH 2892
Query: 521 GQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYA--PLGRSVEVTKMSCQIPQ 578
G+ LS + + + V DVND P + T+ P G + + + +
Sbjct: 2893 GE----KIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSE 2948
Query: 579 EPQRLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPH 638
E R + +Y I GG+ +F ++ V P E+ Y L I D
Sbjct: 2949 EINRQV-TYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG-----T 3002
Query: 639 LSTTATIIVHLVPRR-ASTVATST-HRTTVPSTMTP----MLVTDTEAFWQPQPWFVVVL 692
S+ A + V ++ S V T + T+P + P M ++ T+A + L
Sbjct: 3003 FSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL 3062
Query: 693 TATGA 697
+GA
Sbjct: 3063 LGSGA 3067
Score = 38.1 bits (87), Expect = 0.032
Identities = 41/152 (26%), Positives = 59/152 (38%), Gaps = 19/152 (12%)
Query: 224 VKVLPVPSSQ-----VSFLEQAQNITIPENLAPGSEVVQVQARGV--DLRYEILSPVPSP 276
VKV+ V S Q V F + I E P + VV V+A LRY S
Sbjct: 350 VKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKA 409
Query: 277 LFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLV--NLW 334
FS+ G++ P V R Q FE + K + + V+++ N
Sbjct: 410 KFSLNYNTGLISILEP----------VKRQQAAHFELEVTTSDRKASTKVLVKVLGANSN 459
Query: 335 PPRCLPALLVSQIPETAPVGTVLNTLTCEDPD 366
PP + E P+GT + +L+ DPD
Sbjct: 460 PPEFTQTAYKAAFDENVPIGTTVMSLSAVDPD 491
Score = 37.4 bits (85), Expect = 0.054
Identities = 80/369 (21%), Positives = 134/369 (36%), Gaps = 34/369 (9%)
Query: 167 SIISAQDLPHFPGPFSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGM--VIV 224
SIIS + G FSI+ + + L ++ + L + + G S + V V
Sbjct: 3268 SIISGNE----HGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNV 3323
Query: 225 KVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD------LRYEILSPVPSPLF 278
V + + F + I E+ V+ V A D + Y I+ F
Sbjct: 3324 NVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSF 3383
Query: 279 SIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRC 338
+I G V+ T L+ SG L V+A + G + ++V VN P
Sbjct: 3384 TIDPVRGEVKVTKLLDRETISGYT---LTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVF 3440
Query: 339 LPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNA 398
I E PVG + L D DS + + ++ ++ EVN
Sbjct: 3441 SRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGND-------EKAFEVNP 3493
Query: 399 TLDCDTPGACFQ-----HAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQ 453
T A + + + V D G+PQ+++ + + V + + PA P +
Sbjct: 3494 QGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFIT 3553
Query: 454 EDAAPHT--LLGSVVGTDMDYPHDNIEYYTSGG-PTTFAVDRLSGEVHLLGPLDYEQQRL 510
++ ++G + TD D +D + Y F+V G++ LD Q
Sbjct: 3554 SSGEEYSGGVIGKIHATDQDV-YDTLTYSLDPQMDNLFSVSSTGGKLIAHKKLDIGQ--- 3609
Query: 511 YRLTVLVID 519
Y L V V D
Sbjct: 3610 YLLNVSVTD 3618
>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
Length = 3354
Score = 92.4 bits (228), Expect = 1e-18
Identities = 119/486 (24%), Positives = 202/486 (41%), Gaps = 59/486 (12%)
Query: 199 QAQKVFQLQISVSFGQRQSCQGMVIVKVL--PVPSSQVSFLEQAQNITIPENLAPGSEVV 256
+ Q+ ++L + + G IV +L + S+ FL Q +++ E+ PG+ +
Sbjct: 2135 EEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIA 2194
Query: 257 QVQARGVDLRYEI---------------LSPVPSPLFSIGRADGVVRTTTPL--ELARTS 299
+ A DL ++ L P F++ G V +P+ EL T
Sbjct: 2195 NITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATY 2254
Query: 300 GTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLP---ALLVSQIPETAPVGTV 356
+S + + + + LT+NV VN P+ P + +I E A GT
Sbjct: 2255 EVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTT 2314
Query: 357 LNTLTCEDPDS-VGATLDYKL-------WFRSSSNPASLCLYDRVLEVNATLDCDTPGAC 408
L + DPD + + Y L + + + A + +R ++ +
Sbjct: 2315 LIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYE-----EVHWLN 2369
Query: 409 FQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFR--VQEDAAPHTLLGSVV 466
F AS D G P E+PV + + IN+ +P +++ V ED T++ +V
Sbjct: 2370 FTVRAS----DNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVT 2425
Query: 467 GTDMDYPHDN-IEYYTSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQN 525
TD D + IEY G + FA++ +G++++L LD E++ Y LT L D+ D
Sbjct: 2426 ATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVA 2485
Query: 526 PNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIY--APLGRSVEVTKMSCQIPQEPQRL 583
N S + I+V DVND P+ P ++Y P G SV +T M+ + P
Sbjct: 2486 SNRR-ENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSV-ITMMATDQDEGPNGE 2543
Query: 584 IYSYSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQP-RTYE--LLICVADAGPSTPHLS 640
+ +YS+ G G H D+ G ++P ++YE L VA G P
Sbjct: 2544 L-TYSLEG---------PGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWG 2593
Query: 641 TTATII 646
TT ++
Sbjct: 2594 TTMLLV 2599
Score = 72.4 bits (176), Expect = 2e-12
Identities = 111/452 (24%), Positives = 177/452 (39%), Gaps = 44/452 (9%)
Query: 222 VIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVDLRYE------ILSPVPS 275
V ++V + +F + A +++ EN+ G+ V+ + A +D E I S S
Sbjct: 657 VTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGS 716
Query: 276 PLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWP 335
F I G + TT+ L+ S L V+A + G T+N+ L+++
Sbjct: 717 TQFRINARSGEITTTSLLDRETKSEYI---LIVRAVDGGVGHNQKTGIATVNITLLDIND 773
Query: 336 --PRCLPALLVSQIPETAPVGTVLNTLTCEDPD-SVGATLDYKLW----FRSSSNPASLC 388
P A + E P + + T+ DPD TL Y + F S ++
Sbjct: 774 NHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTG-- 831
Query: 389 LYDRVLEVNATLDCDTPGACFQHAASIL------VLDGGQPQM--TTEVPVLVMVTPINE 440
++ +A LD + P H A ++ V D G+P + T+ V V + +N+
Sbjct: 832 ---KIRTTHAMLDRENPDP---HEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLND 885
Query: 441 FSPACA--PRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTS--GGPTT-FAVDRLSG 495
P P V E + VV D+D + + Y G P F ++ SG
Sbjct: 886 NDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSG 945
Query: 496 EVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQ 555
V LD E+ Y+L V+ D G S + T+TI V DVND P P
Sbjct: 946 VVVTTTELDRERIAEYQLRVVASDAGTPTK-----SSTSTLTIHVLDVNDETPTFFPAVY 1000
Query: 556 ELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPF 615
+++ + R V ++C SY I GGN +F + V +V
Sbjct: 1001 NVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVV--GL 1058
Query: 616 WPEQPRTYELLICVADAGPSTPHLSTTATIIV 647
E Y L++ D GP + TAT+ V
Sbjct: 1059 DRETTAAYMLILEAIDNGPVGKRHTGTATVFV 1090
Score = 67.8 bits (164), Expect = 4e-11
Identities = 77/306 (25%), Positives = 133/306 (43%), Gaps = 30/306 (9%)
Query: 267 YEILSPVPSPLFSIGRADGVVRTTTPLELARTS-GTAVSRLQVKAFEQGQLWASAKLNLT 325
Y++L S LF I + GVV + + + R + + L + A + G L ++A L +T
Sbjct: 2000 YQLLG-AQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLIT 2058
Query: 326 MNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPA 385
+ N P PA L + E P G + +T D DS L+ +L +R +
Sbjct: 2059 ILDDNDNR--PTFSPATLTVHLLENCPPGFSVLQVTATDEDS---GLNGELVYRIEAGAQ 2113
Query: 386 SLCLYDRVLEV----NATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEF 441
L V V NAT+D + + + +++ D G ++ V +++ IN+
Sbjct: 2114 DRFLIHLVTGVIRVGNATIDREEQES---YRLTVVATDRGTVPLSGTAIVTILIDDINDS 2170
Query: 442 SPACAP--RTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSG-------------GPT 486
P +T V E A P T++ ++ D D + +EY+ G
Sbjct: 2171 RPEFLNPIQTVSVLESAEPGTVIANITAIDHDL-NPKLEYHIVGIVAKDDTDRLVPNQED 2229
Query: 487 TFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDH 546
FAV+ +G V + P++ E Y +T+ VID+ D + +T+ V DVND+
Sbjct: 2230 AFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDN 2289
Query: 547 APECEP 552
P+ +P
Sbjct: 2290 TPQFKP 2295
Score = 67.4 bits (163), Expect = 5e-11
Identities = 101/446 (22%), Positives = 174/446 (39%), Gaps = 32/446 (7%)
Query: 221 MVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD------LRYEILSPVP 274
+V ++VL + + L NITI EN S V V A D L + I +
Sbjct: 1836 LVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNR 1895
Query: 275 SPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMN-VQLVNL 333
F I G+V PL+ R ++ + VK + A +L + + N
Sbjct: 1896 ERAFFINATTGIVTVNRPLDRERIPEYKLT-ISVKDNPENPRIARRDYDLLLIFLSDEND 1954
Query: 334 WPPRCLPALLVSQIPETAPVGTVLNTLT-----CEDPDSVGATLDYKLWFRSSSNPASLC 388
P + +++ E +P GT L L + + A + Y+L + S +
Sbjct: 1955 NHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQL-LGAQSGLFDIN 2013
Query: 389 LYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPR 448
V+ V + + D A +L+L + + +L+ + N+ P +P
Sbjct: 2014 SSTGVVTVRSGVIIDRE-AFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPA 2072
Query: 449 TFRVQ--EDAAPHTLLGSVVGTDMDYPHDNIEYYT--SGGPTTFAVDRLSGEVHL-LGPL 503
T V E+ P + V TD D + Y +G F + ++G + + +
Sbjct: 2073 TLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATI 2132
Query: 504 DYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPL 563
D E+Q YRLTV+ D G LSG+ +TI ++D+ND PE P Q +++
Sbjct: 2133 DREEQESYRLTVVATDRGTVP-----LSGTAIVTILIDDINDSRPEFLNPIQTVSVLESA 2187
Query: 564 GRSVEVTKMSC-QIPQEPQRLIYSYSIVGGNSQNRFI--LQGAILVH----SDLVLGPFW 616
+ ++ P+ + IV + +R + + A V+ S +V P
Sbjct: 2188 EPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMN 2247
Query: 617 PEQPRTYELLICVADAGPSTPHLSTT 642
E TYE+ + V D P S +
Sbjct: 2248 RELVATYEVTLSVIDNASDLPERSVS 2273
Score = 64.3 bits (155), Expect = 4e-10
Identities = 123/550 (22%), Positives = 225/550 (40%), Gaps = 68/550 (12%)
Query: 139 IQVPETVTPGARLYTLLLPGLELHG-AQMSIISAQDLPHFPGPFSINEQGWLQAPSQGLL 197
I + E VT G + T+L + ++S + D P FS+++ L L
Sbjct: 467 ISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD----PDRFSLDKDTGLIMLIARLD 522
Query: 198 GQAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQ 257
+ + F L I G + G V + VL V + +F + A + EN +++V+
Sbjct: 523 YELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVR 582
Query: 258 VQARGVD------LRYEILSPVPSPLF---SIGRADGVVRTTTPLELARTSGTAVSRLQV 308
++A D + Y I+S + S+ GV+ + PL+ + S + L V
Sbjct: 583 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIY-LTV 641
Query: 309 KAFEQGQLWASAKLNLTMNVQLVNLWPPR-CLPALLVSQIPETAPVGTVLNTLTCEDPD- 366
A + G ++ + +T+ V N PP PA VS + TVL L D D
Sbjct: 642 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVL-FLNATDLDR 700
Query: 367 -------SVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLD 419
S+ +L+ FR ++ + + LD +T ++ + +D
Sbjct: 701 SREYGQESIIYSLEGSTQFRINARSGEIT-------TTSLLDRETKS---EYILIVRAVD 750
Query: 420 GG--QPQMTTEVPVLVMVTPINEFSPAC--APRTFRVQEDAAPHTLLGSVVGTDMDYPHD 475
GG Q T V + + IN+ P AP + E P + + +VV D D +
Sbjct: 751 GGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGEN 810
Query: 476 NIEYYTSGGPTTF-AVDRLSGEVHLL-------GPLDYEQQRLYRLTVLVIDHGQDQNPN 527
Y+ P F +++ +G++ P +E + + ++ V V D G+ P
Sbjct: 811 GTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGR---PP 867
Query: 528 HHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIP----QEPQRL 583
+ S T+ + + D+ND+ +P FQ L A + + Q+ E
Sbjct: 868 LKATSSATVFVNLLDLNDN----DPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNG 923
Query: 584 IYSYSIVGGNSQNRFILQ---GAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLS 640
+ SY + G + F++ G ++ ++L E+ Y+L + +DAG TP S
Sbjct: 924 LVSYRMPVGMPRMDFLINSSSGVVVTTTELDR-----ERIAEYQLRVVASDAG--TPTKS 976
Query: 641 TTATIIVHLV 650
+T+T+ +H++
Sbjct: 977 STSTLTIHVL 986
Score = 63.9 bits (154), Expect = 5e-10
Identities = 84/320 (26%), Positives = 132/320 (41%), Gaps = 30/320 (9%)
Query: 347 IPETAPVGTVLNTLTCEDPD-SVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDC--D 403
+ E GT + + D D + + L Y + + N DR+ AT D
Sbjct: 1537 VNENVGGGTAVVQVRATDRDIGINSVLSYYI---TEGNKDMAFRMDRISGEIATRPAPPD 1593
Query: 404 TPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQEDAAPHTLLG 463
F H + V D G P ++ V V + N+ +P + V D P TL
Sbjct: 1594 RERQSFYHLVAT-VEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNT 1652
Query: 464 SVV---GTDMDY-PHDNIEYYTSGGP--TTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLV 517
S++ D+D P+ + Y G TF +DR G + LDYE R T++V
Sbjct: 1653 SLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISH-GRYTLIV 1711
Query: 518 IDHGQDQNPNHHLSGSCTITIEVEDVNDHAP----ECEPPFQELTIYAPLGRSVEVTKMS 573
Q +H L+ + T+ + V D+ND+ P + E PF E+T P R T ++
Sbjct: 1712 TATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPF-EVTEGQPGPR--VWTFLA 1768
Query: 574 CQIPQEPQRLIYSYSIVGGNSQNRFIL---QGAILVHSDLVLGPFWPEQPRTYELLICVA 630
P + YSI+ G+ F++ +G + V D+ L E Y L IC
Sbjct: 1769 HDRDSGPNGQV-EYSIMDGDPLGEFVISPVEGVLRVRKDVELD---RETIAFYNLTICAR 1824
Query: 631 DAGPSTPHLSTTATIIVHLV 650
D G P LS+T + + ++
Sbjct: 1825 DRG--MPPLSSTMLVGIRVL 1842
Score = 62.8 bits (151), Expect = 1e-09
Identities = 114/491 (23%), Positives = 195/491 (39%), Gaps = 42/491 (8%)
Query: 243 ITIPENLAPGSEVVQVQARGVD---LRYEILSPVPSPLFSIGRADGVVRTTTPLELARTS 299
+ I E+ GS V Q+ A+ +D L + + S F++ GVV PL+ S
Sbjct: 40 LLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
Query: 300 GTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNT 359
V + Q + K+N+ V VN P +IPE PVGT +
Sbjct: 100 EFTVEF----SVSDHQGVITRKVNI--QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFI 153
Query: 360 LTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLD 419
+ DPD +GA F+ S ++ ++ V LD +T A +Q + D
Sbjct: 154 VNATDPD-LGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQA-YQLTVNATDQD 211
Query: 420 GGQPQMTTEVPVLVMVTPINEFSPAC--APRTFRVQEDAAPHTLLGSVVGTDMDYPHD-N 476
+P ++T + +++T + + P P + + E + P T + + D D
Sbjct: 212 KTRP-LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG 270
Query: 477 IEYYTSGGPTT--FAVDRLSGEVHLLGPLDYEQ---QRLYRLTVLVIDHGQDQNPNHHLS 531
I Y G T FA+D +SG + L G LD E + LTV + D+ P+ +
Sbjct: 271 IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS-DAT 329
Query: 532 GSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRL----IYSY 587
+ T I V D+ND+APE + I L + + Q+ + + L ++
Sbjct: 330 VTTTFNILVIDINDNAPEFNSSEYSVAI-TELAQVGFALPLFIQVVDKDENLGLNSMFEV 388
Query: 588 SIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIV 647
+VG NS + I ++ +D+ + P T + A S P A + +
Sbjct: 389 YLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKI 448
Query: 648 HLVPRRASTVATST--------HRTTVPSTMTPMLVTDTEA--------FWQPQPWFVVV 691
L+ + S TV +++ +L TD +A F+ P +
Sbjct: 449 TLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSL 508
Query: 692 LTATGALLLLA 702
TG ++L+A
Sbjct: 509 DKDTGLIMLIA 519
Score = 61.2 bits (147), Expect = 4e-09
Identities = 97/439 (22%), Positives = 171/439 (38%), Gaps = 41/439 (9%)
Query: 236 FLEQAQNITIPENLAPGSEVVQVQARGVDL----RYEILSPVPSPLFSIGRADGVVRTTT 291
F + NI++ EN+ G+ V+ V A D FS+ + G++
Sbjct: 460 FSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLI---- 515
Query: 292 PLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETA 351
+ +AR + R + + + +NV VN P V + E
Sbjct: 516 -MLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENE 574
Query: 352 PVGTVLNTLTCEDPDSV-GATLDYKLWFRSS-SNPASLCLYDR--VLEVNATLDCD--TP 405
P T L L D DS + Y + S+ + + LY+ V+ V+ LD + +
Sbjct: 575 PSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISN 634
Query: 406 GACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQEDAAPHTLLGSV 465
G + +++ +D G P + + VPV + V N+ P + + V + + G+
Sbjct: 635 GLIY---LTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFV--SVVENIMAGAT 689
Query: 466 V----GTDMD----YPHDNIEYYTSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLV 517
V TD+D Y ++I Y+ G T F ++ SGE+ LD E + Y L V
Sbjct: 690 VLFLNATDLDRSREYGQESI-IYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA 748
Query: 518 IDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIP 577
+D G N +G T+ I + D+ND+ P + + + +VT + P
Sbjct: 749 VDGGVGHNQK---TGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP 805
Query: 578 QEPQRLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPRTYE------LLICVAD 631
+ YSI N+F + E P +E +++ V D
Sbjct: 806 DLGENGTLVYSI---QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTD 862
Query: 632 AGPSTPHLSTTATIIVHLV 650
G +++AT+ V+L+
Sbjct: 863 CGRPPLKATSSATVFVNLL 881
Score = 59.3 bits (142), Expect = 1e-08
Identities = 98/439 (22%), Positives = 170/439 (38%), Gaps = 50/439 (11%)
Query: 238 EQAQNITIPENLAPGSEVVQVQARGVD------LRYEILSPVPSPLFSIGRADGVVRTTT 291
+Q + + E G+ V+ VQA D + Y ILS F I + G++ T
Sbjct: 1211 QQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK-FEIDESTGLIITVN 1269
Query: 292 PLELARTSGTAVSRL---QVKAFEQG--QLWASAKLNLTMNVQLVNLWPPRCLPALLVSQ 346
L+ + ++ Q F QG ++ + L VQ N A +
Sbjct: 1270 YLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSN--------ASYEAA 1321
Query: 347 IPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDR---VLEVNATLDCD 403
I E +GT + + D++ + Y+ +S+ +L D V+ V +D +
Sbjct: 1322 ILENLALGTEIVRVQAYSIDNLNQ-ITYRFNAYTSTQAKALFKIDAITGVITVQGLVDRE 1380
Query: 404 TPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPA---CAPRTFRVQEDAAPHT 460
+V D G P++ + V V + V N+ SP + + ED
Sbjct: 1381 KG----DFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQ 1436
Query: 461 LLGSVVGTDMDY-PHDNIEYYTSGGPTTFAVDRLS-----GEVHLLGPLDYEQQRLYRLT 514
+ +V D D + + + + G A + ++ GEV + PLD E+ Y L
Sbjct: 1437 RVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQ 1496
Query: 515 VLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPF-QELTIYAPLGRSVEVTKMS 573
V+ D G H+ + + + D+ND+ P E PF +++ +G V ++
Sbjct: 1497 VVASDRGTPPRKKDHI-----LQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVR 1551
Query: 574 CQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPRT--YELLICVAD 631
+ SY I GN F + + ++ P P++ R Y L+ V D
Sbjct: 1552 ATDRDIGINSVLSYYITEGNKDMAFRMD---RISGEIATRPAPPDRERQSFYHLVATVED 1608
Query: 632 AGPSTPHLSTTATIIVHLV 650
G TP LS T + V +V
Sbjct: 1609 EG--TPTLSATTHVYVTIV 1625
Score = 53.9 bits (128), Expect = 6e-07
Identities = 82/313 (26%), Positives = 126/313 (40%), Gaps = 46/313 (14%)
Query: 349 ETAPVGTVLNTLTCEDPDSVG-ATLDYKLWFRSSS---NPASLCLY-----DRVLE---V 396
E PVGT++ T+T D DS A ++Y L S NP + +Y DR + +
Sbjct: 2413 EDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYI 2472
Query: 397 NATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTF--RVQE 454
L D PG D + V V++ V +N+ P + F V E
Sbjct: 2473 LTALAKDNPG------------DVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYE 2520
Query: 455 DAAPHTLLGSVVGTDMDY-PHDNIEYYTSG-GPTTFAVDRLSGEVHLLGPL-DYEQQRLY 511
+ T + +++ TD D P+ + Y G G F VD SG V PL YE+ +
Sbjct: 2521 NEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEK---F 2577
Query: 512 RLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIY----APLGRSV 567
LTV+ D G+ L G+ + +EV DVND+ P P ++ PL +V
Sbjct: 2578 SLTVVATDGGEPP-----LWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNV 2632
Query: 568 EVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAI--LVHSDLVLGPFWPEQPRTYEL 625
+ + + YS+ GN F + I L+ + L E Y L
Sbjct: 2633 YEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLD---RESQAVYSL 2689
Query: 626 LICVADAGPSTPH 638
++ +D G P+
Sbjct: 2690 ILVASDLGQPVPY 2702
Score = 52.8 bits (125), Expect = 1e-06
Identities = 78/358 (21%), Positives = 146/358 (40%), Gaps = 42/358 (11%)
Query: 213 GQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD------LR 266
G+R + V V VL V ++ FL+ + ++PE++ G ++Q++A D +
Sbjct: 1079 GKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVW 1138
Query: 267 YEILSPVPSPLFSIGRADG-VVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLT 325
Y IL F I ++G ++R PL+ R S L V+A+ + + +
Sbjct: 1139 YRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHV---LIVEAYNHDLGPMRSSVRVI 1195
Query: 326 MNVQLVNLWPPRCLPALLVSQ------IPETAPVGTVLNTLTCEDPDS-VGATLDYKLWF 378
+ V+ +N P + Q + ETA +GT + + D DS G ++Y++
Sbjct: 1196 VYVEDINDEAP-----VFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILS 1250
Query: 379 RSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPI 438
+ ++ VN LD +T + + ++ Q + V +T +
Sbjct: 1251 GAEGKFEIDESTGLIITVN-YLDYETKTSYMMNVSAT-----DQAPPFNQGFCSVYITLL 1304
Query: 439 NEFSPACAPRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIE--------YYTSGGPTTFAV 490
NE A + + LG+ + Y DN+ Y ++ F +
Sbjct: 1305 NELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKI 1364
Query: 491 DRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAP 548
D ++G + + G +D E+ Y LTV+ D G + + + I V D ND++P
Sbjct: 1365 DAITGVITVQGLVDREKGDFYTLTVVADDGGP------KVDSTVKVYITVLDENDNSP 1416
Score = 45.1 bits (105), Expect = 3e-04
Identities = 34/121 (28%), Positives = 58/121 (47%), Gaps = 12/121 (9%)
Query: 433 VMVTPINEFS--PACAPRTFRVQ--EDAAPHTLLGSVVGTDMDY-PHDNIEYYTSGGPTT 487
V +T INE P + + + E+ T + +V+ TD D + Y+ S P
Sbjct: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR 505
Query: 488 FAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHA 547
F++D+ +G + L+ LDYE + + LT++ D G ++ + I V DVND+
Sbjct: 506 FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGR-------VRINVLDVNDNV 558
Query: 548 P 548
P
Sbjct: 559 P 559
Score = 35.8 bits (81), Expect = 0.16
Identities = 89/406 (21%), Positives = 168/406 (41%), Gaps = 45/406 (11%)
Query: 265 LRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNL 324
+ Y I+ P F I +GV+R +EL R + A L + A ++G S+ + +
Sbjct: 1779 VEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRET-IAFYNLTICARDRGMPPLSSTMLV 1837
Query: 325 TMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDS-VGATLDYKLWFRSSSN 383
+ V +N P L + I E +PV + + + D DS A L + + +
Sbjct: 1838 GIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRER 1897
Query: 384 PASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQ-PQMTTE--VPVLVMVTPINE 440
+ ++ VN LD + ++ +I V D + P++ +L+ ++ N+
Sbjct: 1898 AFFINATTGIVTVNRPLDRE---RIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDEND 1954
Query: 441 FSPACAPRTFR--VQEDA---APHTLL-GSVVGTDMDYP-HDNIEYYTSGGPT-TFAVDR 492
P T++ V E++ P T+L G ++ D D + + Y G + F ++
Sbjct: 1955 NHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINS 2014
Query: 493 LSGEVHLLGPLDYEQQR----LYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAP 548
+G V + + +++ + L +L D G L+ + + I + D ND+ P
Sbjct: 2015 STGVVTVRSGVIIDREAFSPPILELLLLAEDIGL-------LNSTAHLLITILDDNDNRP 2067
Query: 549 ECEPPFQELTIY----APLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQ--- 601
P LT++ P G SV + + L+Y + +Q+RF++
Sbjct: 2068 TFSP--ATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYR---IEAGAQDRFLIHLVT 2122
Query: 602 GAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIV 647
G I V + + E+ +Y L + D G T LS TA + +
Sbjct: 2123 GVIRVGNATI----DREEQESYRLTVVATDRG--TVPLSGTAIVTI 2162
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 92.0 bits (227), Expect = 2e-18
Identities = 125/424 (29%), Positives = 177/424 (41%), Gaps = 40/424 (9%)
Query: 142 PETVTPGARLYTLLLPGLELHGAQMSIISAQDLPHFPGPFSINEQGWLQ-APSQGLLGQA 200
P TP L TL + GA SI+ PG + G ++ A S LG
Sbjct: 1974 PSFSTPTLALATLRAEDRDA-GANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPR 2032
Query: 201 QKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQ--- 257
+V + + +S G++IV + F + TI EN PG+ +V
Sbjct: 2033 DRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRA 2092
Query: 258 VQARGVD--LRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQ 315
V A G + + Y ILS FSI + G + T E + RL ++A E G
Sbjct: 2093 VHAGGTNGPITYSILSGNEKGTFSIQPSTGAI-TVRSAEGLDFEVSPRLRLVLQA-ESGG 2150
Query: 316 LWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDS-VGATLDY 374
+A L LT+ Q N PR L V+ +PE+ P+ L + +D D G + Y
Sbjct: 2151 AFAFTVLTLTL--QDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISY 2208
Query: 375 KLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQH---AASILVL---DGGQPQMTTE 428
L ++S PA + V+ T T A A + LVL D G P +
Sbjct: 2209 SL---AASQPAR-----GLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGS 2260
Query: 429 VPVLVMVTPINEFSPACA-PRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYT---SGG 484
+ VMV N+ P P RV EDA + + V G D+D + +Y SG
Sbjct: 2261 ATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVD--SGPVLWYVLSPSGP 2318
Query: 485 PTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVN 544
F+V R G V L GPLD+EQ Y+L +L D + G +T+ VEDVN
Sbjct: 2319 QDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHE--------GRANLTVLVEDVN 2370
Query: 545 DHAP 548
D+AP
Sbjct: 2371 DNAP 2374
Score = 88.2 bits (217), Expect = 3e-17
Identities = 131/493 (26%), Positives = 203/493 (41%), Gaps = 46/493 (9%)
Query: 178 PGPFSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQV-SF 236
P F+++EQ L + L +A V QL+I G + V + VP +
Sbjct: 730 PPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPI 789
Query: 237 LEQAQNI-TIPENLAPGSEVVQVQARGVDLRYEILSPV--------PSPLFSIGRADGVV 287
EQ Q + ++PE++APG+ V VQA R L+PV P LFS+ G++
Sbjct: 790 FEQLQYVFSVPEDVAPGTSVGIVQAHNPPGR---LAPVTLSLSGGDPRGLFSLDAVSGLL 846
Query: 288 RTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRC-LPALLVSQ 346
+T PL+ R V L+V+A G A A + + + VN P P V
Sbjct: 847 QTLRPLD--RELLGPVLELEVRA-GSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLL 903
Query: 347 IPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPG 406
P TAP GT + TL DPDS ++ ++ F + D + P
Sbjct: 904 PPNTAP-GTPIYTLRALDPDS---GVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPS 959
Query: 407 ACFQHAASILVLDGGQPQMTTEVPVLVMVTPINE--FSPACAPRTFRVQEDAAPHTLLGS 464
H + DGG P T+ + V+V + +P T+RV D T G+
Sbjct: 960 GGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRV--DLPSGTTAGT 1017
Query: 465 VVGTDMDYPHDN--IEYY--TSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDH 520
V D I Y+ G + F ++ SG + + LD E Q LY L V+ +
Sbjct: 1018 QVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSG 1077
Query: 521 GQDQNPNHHLSGSCTITIEVEDVNDHAPEC--EPPFQELTIYAPLGRSVEVTKMSCQIPQ 578
+ + +G+ T+ + + + N+H+P +P F + P G SV + +
Sbjct: 1078 SKAELGQQ--TGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSG 1135
Query: 579 EPQRLIYSYSIVGGNSQNRFILQGAILVHSD----LVLGPFWPEQPRTYELLICVADAGP 634
RL YS + +S+ A +H L EQ +Y+LL+ V D G
Sbjct: 1136 PNGRLTYSLQQLSEDSK-------AFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGG- 1187
Query: 635 STPHLSTTATIIV 647
+P STT T+ V
Sbjct: 1188 -SPPRSTTGTVHV 1199
Score = 85.1 bits (209), Expect = 2e-16
Identities = 124/501 (24%), Positives = 194/501 (38%), Gaps = 53/501 (10%)
Query: 180 PFSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQ 239
PFS+ G + + L + +QLQ+ G + + ++ V V + +F +
Sbjct: 2321 PFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVL-VEDVNDNAPAFSQS 2379
Query: 240 AQNITIPENLAPGSEVVQVQARGVD------LRYEILSPVPSPLFSIGRADGVVRTTTPL 293
+ + E+ PGS ++ V A D + Y + SP FS+ +G + T
Sbjct: 2380 LYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG--FSVDPNNGTLFTIVGT 2437
Query: 294 ELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPV 353
G+ + ++A + G +A+ + + +Q N P + + E P
Sbjct: 2438 VALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPP 2497
Query: 354 GTVLNTLTCEDPDSVG--ATLDYKL----WFR------------SSSNPASLCLYDRVLE 395
G+ L TL D D A +DY + W R S+ P L VL
Sbjct: 2498 GSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLL 2557
Query: 396 VNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFR--VQ 453
+ T Q+ ++ D GQP ++ VPV V V +N+ P ++R V
Sbjct: 2558 EPLDFESLT-----QYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVP 2612
Query: 454 EDAAPHTLLGSVVGTDMD-YPHDNIEYYTSGGPTT--FAVDRLSGEVHLLGPLDYEQQRL 510
ED L V +D D PH + + S G + F +D SG + L LD E Q
Sbjct: 2613 EDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQAR 2672
Query: 511 YRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTI--YAPLGRSVE 568
++L V Q +P +TIEV+DVNDH P ++ P G V
Sbjct: 2673 HQLVV------QAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVT 2726
Query: 569 VTKMSCQIPQEPQRLIYSYSIVGGNSQNR--FILQGAILVHSDLVLGPFWPEQPRTYELL 626
RL YS G + R F L + V PF E ++ LL
Sbjct: 2727 TLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARV--PFDYEHTESFRLL 2784
Query: 627 ICVADAGPSTPHLSTTATIIV 647
+ ADAG +LS + T+ V
Sbjct: 2785 VGAADAG----NLSASVTVSV 2801
Score = 82.4 bits (202), Expect = 1e-15
Identities = 92/363 (25%), Positives = 157/363 (43%), Gaps = 35/363 (9%)
Query: 219 QGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD------LRYEI--- 269
Q ++ V +L + +F + + + E+LAPGS V+QV A D + YEI
Sbjct: 238 QALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRR 297
Query: 270 LSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQ 329
S P FSI G+++ PL+ + V L V+A + G +T++V+
Sbjct: 298 QSEGDGP-FSIDAHTGLLQLERPLDFEQRR---VHELVVQARDGGAHPELGSAFVTVHVR 353
Query: 330 LVNLWPPRCLPALLVS----QIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPA 385
N P L + Q+ E AP G ++ ++ DPD G +
Sbjct: 354 DANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDD-GDFAHVNVSLEGGEGHF 412
Query: 386 SLCLYDRVLE---VNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFS 442
+L D V+ V LD + A + + D G P + E ++ VT +N+ +
Sbjct: 413 ALSTQDSVIYLVCVARRLDREERDA---YNLRVTATDSGSPPLRAEAAFVLHVTDVNDNA 469
Query: 443 PACAPRTFRVQ---EDAAPHTLLGSVVGTDMDY-PHDNIEYYTSGGPTT--FAVDRLSGE 496
PA + +R + E A P + + V D D + + Y + G T F++D SG
Sbjct: 470 PAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGI 529
Query: 497 VHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQE 556
+ LDYE + +L V+ D G L+ S T+++ ++DVND+ P+ + F
Sbjct: 530 ITTAASLDYELEPQPQLIVVATDGGLPP-----LASSATVSVALQDVNDNEPQFQRTFYN 584
Query: 557 LTI 559
++
Sbjct: 585 ASL 587
Score = 80.1 bits (196), Expect = 7e-15
Identities = 148/613 (24%), Positives = 237/613 (38%), Gaps = 76/613 (12%)
Query: 118 VQRDLSHIQCAGQFASPAG--EMIQVPETVTPGA---RLYTLLLPGLELHGAQMSIISAQ 172
VQ ++ G A P+ ++ VP T TP Y +P G + I+ A
Sbjct: 756 VQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAH 815
Query: 173 DLPHFPGPFSINEQGW-----------------LQAPSQGLLGQAQKVFQLQISVSFGQR 215
+ P P +++ G L+ + LLG V +L++ G
Sbjct: 816 NPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGP---VLELEVRAGSGVP 872
Query: 216 QSCQGMVIVKVL--PVPSSQVSFLEQAQNITIPENLAPGSEVVQVQA----RGVDLRYEI 269
+ + V+VL V + +F + +P N APG+ + ++A GV+ R
Sbjct: 873 PAF-AVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTF 931
Query: 270 -LSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNV 328
L F++ G VR PL SG L+++A + G ++ L + V
Sbjct: 932 TLLAGGGGAFTVDPTTGHVRLMRPLG---PSGGPAHELELEARDGGSPPRTSHFRLRVVV 988
Query: 329 QLVNL--WPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPAS 386
Q V PR +P GT + + + PD G + Y L +S+P
Sbjct: 989 QDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD--GGPITYHLAAEGASSPFG 1046
Query: 387 LCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACA 446
L L V A LD + ++ Q T V V + NE SP +
Sbjct: 1047 LEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLS 1106
Query: 447 --PRTFRVQEDAAPHTLLGSVVGTDMDY-PHDNIEY---YTSGGPTTFAVDRLSGEVHLL 500
P V E+ P T +G V TD D P+ + Y S F + +GEV L
Sbjct: 1107 EDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTL 1166
Query: 501 GPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIY 560
LD EQQ Y+L V V D G +P +G T+ + V D+ND++ P F + +
Sbjct: 1167 QTLDREQQSSYQLLVQVQDGG---SPPRSTTG--TVHVAVLDLNDNS----PTFLQASGA 1217
Query: 561 APLGRSVE----------VTKMSCQIPQEPQRLIYSYSIVGGNSQNRFIL---QGAILVH 607
A G ++ VT + + P E + Y++ G S+ F L G +L
Sbjct: 1218 AGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSE-LFSLHPHSGELLTA 1276
Query: 608 SDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTHRTTVP 667
+ L+ E+P Y L + D G +P S + ++V ++P P
Sbjct: 1277 APLIRA----ERPH-YVLTLSAHDQG--SPPRSASLQLLVQVLPSARLAEPPPDLAERDP 1329
Query: 668 STMTPMLVTDTEA 680
+ P+++T T A
Sbjct: 1330 AAPVPVVLTVTAA 1342
Score = 78.2 bits (191), Expect = 3e-14
Identities = 124/461 (26%), Positives = 171/461 (37%), Gaps = 62/461 (13%)
Query: 125 IQCAGQFASPAGEMIQVPETVTPGAR-----------------LYTLLLPGLEL---HGA 164
+Q +G A+ G IQVP+ V PG LYTL PG EL H
Sbjct: 1212 LQASG--AAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPH 1269
Query: 165 QMSIISAQDL-----PHFPGPFSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQ 219
+++A L PH+ S ++QG P L QL + V R +
Sbjct: 1270 SGELLTAAPLIRAERPHYVLTLSAHDQG--SPPRSASL-------QLLVQVLPSARLAEP 1320
Query: 220 GMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQA---RGVD-LRYEILSPV-P 274
+ + P V +T E L PGS + V A GV L Y ++ P
Sbjct: 1321 PPDLAERDPAAPVPVVL-----TVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADP 1375
Query: 275 SPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKL-NLTMNVQLVNL 333
F++ A G + PL+ +G L V+A +G A A+L + + VQ N
Sbjct: 1376 EGTFALDAASGRLYLARPLDFE--AGPPWRALTVRA--EGPGGAGARLLRVQVQVQDENE 1431
Query: 334 WPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDR- 392
P L +PE G L T D D G D + P D
Sbjct: 1432 HAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDAR 1491
Query: 393 --VLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACA-PRT 449
L LD +T A + + V V VT N+ +P A P
Sbjct: 1492 TGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSR 1551
Query: 450 FRVQEDAAPHTLLGSVVGTDMDYPHDNIEYY--TSGGPTTFAVDRLSGEVHLLGPLDYEQ 507
R+ ED P VV D D Y SGG F + +G + ++ PLD EQ
Sbjct: 1552 VRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQ 1611
Query: 508 QRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAP 548
+ + LTV+ DHG S + +T+ V DVND AP
Sbjct: 1612 RAEHVLTVVASDHGSPPR-----SATQVLTVSVADVNDEAP 1647
Score = 73.9 bits (180), Expect = 5e-13
Identities = 104/438 (23%), Positives = 168/438 (38%), Gaps = 54/438 (12%)
Query: 235 SFLEQAQNITIPENLAPGSEVVQVQARGVD-------LRYEILS---PVPSPLF-----S 279
+F + +PEN PG+ + +A D +RY +L PVP+ +
Sbjct: 1435 AFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGA 1494
Query: 280 IGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCL 339
+ G+ R TTP L T A + SA++ +T P
Sbjct: 1495 LSAPRGLDRETTPALLLLVEATD---RPANASRRRAARVSARVFVTDENDNA---PVFAS 1548
Query: 340 PALLVSQIPETAPVGTVLNTLTCEDPD-SVGATLDYKLWFRSSSNPASLCLYDRVLEVNA 398
P+ + ++PE P G + DPD A + Y+L +S L+ ++
Sbjct: 1549 PSRV--RLPEDQPPGPAALHVVARDPDLGEAARVSYRL---ASGGDGHFRLHSSTGALSV 1603
Query: 399 TLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFRV--QEDA 456
D +H +++ D G P + + V V +N+ +P + + V +E+
Sbjct: 1604 VRPLDREQRA-EHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENN 1662
Query: 457 APHTLLGSVVGTDMDYPHDNIEYYTSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVL 516
P T L ++ TD D + Y +F++D +G + L LD E+Q LTV
Sbjct: 1663 PPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVY 1722
Query: 517 VIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVE-VTKMSCQ 575
D G H T+ + VED NDHAP L++ P G+ + +T +
Sbjct: 1723 AQDRGSPPQLTH-----VTVRVAVEDENDHAPTFGS--AHLSLEVPEGQDPQTLTMLRAS 1775
Query: 576 IPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQP------RTYELLICV 629
P Y I+ G+ F+L DL G F +P ++L I
Sbjct: 1776 DPDVGANGQLQYRILDGDPSGAFVL--------DLASGEFGTMRPLDREVEPAFQLRIEA 1827
Query: 630 ADAGPSTPHLSTTATIIV 647
D G P LS T + V
Sbjct: 1828 RDGG--QPALSATLLLTV 1843
Score = 72.4 bits (176), Expect = 2e-12
Identities = 107/393 (27%), Positives = 165/393 (41%), Gaps = 43/393 (10%)
Query: 139 IQVPETVTPGARLYTLLLP---GLELHGA-QMSIISAQDLPHFPGPFSINEQGWLQAPSQ 194
+ V E + PG+ L TL G H A SIIS F + E G P
Sbjct: 2489 VAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGP 2548
Query: 195 GLLG--------QAQKVFQLQISVSFGQR----QSCQGMVIVKVLPVPSSQVSFLEQAQN 242
LG + + Q ++V+ R QS V V VL V + F +
Sbjct: 2549 RALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYR 2608
Query: 243 ITIPENLAPGSEVVQVQARGVD------LRYEILSPVPSPLFSIGRADGVVRTTTPLELA 296
+T+PE+ G+E++ V+A D +R+ + S PS LF + + G +R L+
Sbjct: 2609 VTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCE 2668
Query: 297 RTSGTAVSRLQVKAFEQ-GQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGT 355
A +L V+A + G +A A + T+ VQ VN P LL + + E P GT
Sbjct: 2669 TQ---ARHQLVVQAADPAGAHFALAPV--TIEVQDVNDHGPAFPLNLLSTSVAENQPPGT 2723
Query: 356 VLNTLTCEDPDSVG-ATLDYKLWFRSSSNPA---SLCLYDRVLEVNATLDCDTPGACFQH 411
++ TL D D+ L Y L + P + L E+ A + D ++H
Sbjct: 2724 LVTTLHAIDGDAGAFGRLRYSL-LEAGPGPEGREAFALNSSTGELRARVPFD-----YEH 2777
Query: 412 AASILVLDGGQP--QMTTEVPVLVMVTPINEFSPA-CAPRT-FRVQEDAAPHTLLGSVVG 467
S +L G ++ V V V+VT +E+ P AP F+V E A LG V
Sbjct: 2778 TESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQA 2837
Query: 468 TDMDYPHDNIEYYT-SGGPTTFAVDRLSGEVHL 499
TD D D + Y+ + F +++ +G ++L
Sbjct: 2838 TDEDGGADGLVLYSLATSSPYFGINQTTGALYL 2870
Score = 68.6 bits (166), Expect = 2e-11
Identities = 86/351 (24%), Positives = 137/351 (39%), Gaps = 34/351 (9%)
Query: 320 AKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVG-ATLDYKL-- 376
A + +T+ V +N P A Q+PE GT D D+ T Y L
Sbjct: 125 ATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSG 184
Query: 377 -----WFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPV 431
FR + P L V LD + + + DGG P + +
Sbjct: 185 DGAGETFRLETRPGPDGTPVPELVVTGELDRENRS---HYMLQLEAYDGGSPPRRAQALL 241
Query: 432 LVMVTPINEFSPACAPRTFR--VQEDAAPHTLLGSVVGTDMDYPHDNIEYYT-----SGG 484
V + IN+ +PA + V E AP + + V +D D + Y S G
Sbjct: 242 DVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEG 301
Query: 485 PTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVN 544
F++D +G + L PLD+EQ+R++ L V D G H GS +T+ V D N
Sbjct: 302 DGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGA-----HPELGSAFVTVHVRDAN 356
Query: 545 DHAPECEPPF------QELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRF 598
D+ P F +++ AP G+ V ++S P + + S+ GG
Sbjct: 357 DNQPSMTVIFLSADGSPQVSEAAPPGQL--VARISVSDPDDGDFAHVNVSLEGGEGHFAL 414
Query: 599 ILQGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHL 649
Q ++ ++ V E+ Y L + D+G +P L A ++H+
Sbjct: 415 STQDSV-IYLVCVARRLDREERDAYNLRVTATDSG--SPPLRAEAAFVLHV 462
Score = 67.0 bits (162), Expect = 6e-11
Identities = 102/452 (22%), Positives = 179/452 (39%), Gaps = 48/452 (10%)
Query: 245 IPENLAPGSEVVQVQARGVD------LRYEILSPVPSP-LFSIGRADGVVRTTTPLELAR 297
+PE+ ++QV+A +D + Y + + P+ LF + G + TT L+
Sbjct: 2180 LPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREI 2239
Query: 298 TSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVL 357
+ T RL + A ++G LT+ V N P +P ++ E A +G+ +
Sbjct: 2240 WAET---RLVLMATDRGSPALVGSATLTVMVIDTNDNRPT-IPQPWELRVSEDALLGSEI 2295
Query: 358 NTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILV 417
+T D DS G L Y L +P S+ Y + + LD + C ++ +L
Sbjct: 2296 AQVTGNDVDS-GPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQ---CDRYQLQLLA 2351
Query: 418 LDG---GQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQ--EDAAPHTLLGSVVGTDMDY 472
DG G+ +T V+V +N+ +PA + ++V E P + + SV TD D
Sbjct: 2352 HDGPHEGRANLT------VLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDS 2405
Query: 473 -PHDNIEYYTSGGPTTFAVDRLSGEVHLLG---PLDYEQQRLYRLTVLVIDHGQDQNPNH 528
+ +I Y+ + F+VD +G + + L ++ + + DHG
Sbjct: 2406 GANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGR--- 2462
Query: 529 HLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGR-SVEVTKMSCQIPQEPQRLIYSY 587
+ T+ ++++D NDHAP + + L S +T + Y
Sbjct: 2463 --AARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDY 2520
Query: 588 SIVGGNSQNRFILQGAILVHSD------------LVLGPFWPEQPRTYELLICVADAGPS 635
SI+ GN F L+ + + ++L P E Y L + AD G
Sbjct: 2521 SIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQP 2580
Query: 636 TPHLSTTATIIVHLVPRRASTVATSTHRTTVP 667
T+ V V +++R TVP
Sbjct: 2581 PQSSVVPVTVTVLDVNDNPPVFTRASYRVTVP 2612
Score = 63.9 bits (154), Expect = 5e-10
Identities = 115/477 (24%), Positives = 181/477 (37%), Gaps = 53/477 (11%)
Query: 222 VIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD------LRYEI---LSP 272
V V + V ++ F N ++PE PG+ +QV A D L Y + L
Sbjct: 564 VSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGS 623
Query: 273 VPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVN 332
SP F I G V TT L+ R G + V A + G L + + + ++ + N
Sbjct: 624 SGSPPFRIDAHSGDVCTTRTLD--RDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDN 681
Query: 333 LWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVG-ATLDYKLWFRSSSNPASLCLYD 391
PP+ P + I +P GT + L DPD L Y + + N L D
Sbjct: 682 --PPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHI---LAGNSPPLFTLD 736
Query: 392 RVLEVNATLDCDTPGACFQHAASILVL-----DGGQPQMTTEVPVLVMVTPINEFSPAC- 445
E + L P A + A S++ L DGG Q V + + P P
Sbjct: 737 ---EQSGLLTVAWPLA--RRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFE 791
Query: 446 -APRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPT--TFAVDRLSGEVHLLGP 502
F V ED AP T +G V + + SGG F++D +SG + L P
Sbjct: 792 QLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRP 851
Query: 503 LDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAP 562
LD ++ L + L + G P ++ + + ++DVND++P P + +
Sbjct: 852 LD--RELLGPVLELEVRAGSGVPPAFAVA---RVRVLLDDVNDNSPAFPAPEDTVLLPPN 906
Query: 563 LGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSDL----VLGPFWPE 618
+ + P +++++ G GA V ++ P P
Sbjct: 907 TAPGTPIYTLRALDPDSGVNSRVTFTLLAGGG-------GAFTVDPTTGHVRLMRPLGPS 959
Query: 619 QPRTYELLICVADAG--PSTPHLSTTATIIVHLVPRR--ASTVATSTHRTTVPSTMT 671
+EL + D G P T H ++V V R A + T+R +PS T
Sbjct: 960 GGPAHELELEARDGGSPPRTSHF--RLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTT 1014
Score = 60.8 bits (146), Expect = 5e-09
Identities = 87/347 (25%), Positives = 135/347 (38%), Gaps = 49/347 (14%)
Query: 235 SFLEQAQNITIPENLAPGSEVVQVQARGVD-------LRYEILSPVPSPLFSIG------ 281
SF + + E+L PGS ++ ++A D + Y I+S +F +
Sbjct: 2481 SFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEA 2540
Query: 282 --------RADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNL 333
RA G + PL+ L V A ++GQ S+ + +T+ V VN
Sbjct: 2541 GESAGPGPRALGCLVLLEPLDF---ESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVND 2597
Query: 334 WPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDR- 392
PP A +PE PVG L + D D L + SS +P+ L D
Sbjct: 2598 NPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGL--VRFTVSSGDPSGLFELDES 2655
Query: 393 --VLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTF 450
L + LDC+T +H + D PV + V +N+ PA
Sbjct: 2656 SGTLRLAHALDCETQA---RHQLVVQAADPAGAHFAL-APVTIEVQDVNDHGPAFPLNLL 2711
Query: 451 R--VQEDAAPHTLLGSVVGTDMDYPHDNIEYYT--SGGP-----TTFAVDRLSGEVHLLG 501
V E+ P TL+ ++ D D Y+ GP FA++ +GE+
Sbjct: 2712 STSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARV 2771
Query: 502 PLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAP 548
P DYE +RL V D G +LS S T+++ V +++ P
Sbjct: 2772 PFDYEHTESFRLLVGAADAG-------NLSASVTVSVLVTGEDEYDP 2811
Score = 60.5 bits (145), Expect = 6e-09
Identities = 92/365 (25%), Positives = 145/365 (39%), Gaps = 42/365 (11%)
Query: 265 LRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNL 324
L+Y IL PS F + A G T PL+ +L+++A + GQ SA L L
Sbjct: 1785 LQYRILDGDPSGAFVLDLASGEFGTMRPLD---REVEPAFQLRIEARDGGQPALSATLLL 1841
Query: 325 TMNVQLVNLWPPRC-LPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSN 383
T+ V N P +PA V ++PE P GT+L L DPD+ GA + ++ +
Sbjct: 1842 TVTVLDANDHAPAFPVPAYSV-EVPEDVPAGTLLLQLQAHDPDA-GAN-GHVTYYLGAGT 1898
Query: 384 PASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQP-QMTTEVPVLVMVTPINEFS 442
+ L E+ D C + S+ +DG ++T V V + V +N+ +
Sbjct: 1899 AGAFLLEPSSGELRTAAALDRE-QCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHA 1957
Query: 443 PACAPRTFRVQ------EDAAPHTLLGSVVGTDMDYPHDNIEYYTSGG--PTTFAVDRLS 494
P R++ + P L ++ D D + Y G P VD +
Sbjct: 1958 PTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYT 2017
Query: 495 GEVHL------LGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAP 548
GE+ + LGP D L ++ D G+ S + I + ++ + P
Sbjct: 2018 GEIRVARSPVALGPRDRV------LFIVATDLGRPAR-----SATGVIIVGLQGEAERGP 2066
Query: 549 ECEPPFQELTI--YAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQ---GA 603
E TI AP G + + + +YSI+ GN + F +Q GA
Sbjct: 2067 RFPRASSEATIRENAPPGTPIVSPR---AVHAGGTNGPITYSILSGNEKGTFSIQPSTGA 2123
Query: 604 ILVHS 608
I V S
Sbjct: 2124 ITVRS 2128
Score = 52.4 bits (124), Expect = 2e-06
Identities = 72/292 (24%), Positives = 117/292 (40%), Gaps = 22/292 (7%)
Query: 245 IPENLAPGSEVVQVQARGVD------LRYEILSPVPSPLFSIGRADGVVRTTTPLELART 298
+PE PGS VV+V AR D + Y + + FSI G++ T L+
Sbjct: 482 LPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELE 541
Query: 299 SGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLN 358
+L V A + G ++ +++ +Q VN P+ + +PE GT
Sbjct: 542 PQP---QLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFL 598
Query: 359 TLTCEDPDS-VGATLDYKLWF---RSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAAS 414
+T D DS L Y L S S P + + + TLD D + F +
Sbjct: 599 QVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDF--T 656
Query: 415 ILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTF--RVQEDAAPHTLLGSVVGTDMDY 472
+ +DGG + + V V V ++ N+ P PR + + + P T + + D D
Sbjct: 657 VTAVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQ 714
Query: 473 -PHDNIEYYTSGG--PTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHG 521
H + Y+ G P F +D SG + + PL + +L + D G
Sbjct: 715 GSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGG 766
Score = 45.1 bits (105), Expect = 3e-04
Identities = 89/403 (22%), Positives = 152/403 (37%), Gaps = 64/403 (15%)
Query: 199 QAQKVFQLQISVSFGQRQSCQGMVI--VKVLPVPSSQVSFLEQAQNITIPENLAPGSEVV 256
+ + FQL+I G + + ++ V VL +F A ++ +PE++ G+ ++
Sbjct: 1816 EVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLL 1875
Query: 257 QVQARGVDLRYE-----ILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAF 311
Q+QA D L + F + + G +RT L+ + S V
Sbjct: 1876 QLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGA 1935
Query: 312 EQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGT----VLNTLTCEDPDS 367
G L S +++T+ V+ VN P + L ++P P + L TL ED D+
Sbjct: 1936 AAGPL--STTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDA 1993
Query: 368 ---------------VGATLD-YKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQH 411
G T+D Y R + +P +L DRVL + AT
Sbjct: 1994 GANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVAT------------ 2041
Query: 412 AASILVLDGGQPQMTTEVPVLVMVTPINEFSPAC--APRTFRVQEDAAPHTLLGSVVGTD 469
D G+P + ++V + E P A ++E+A P T + S
Sbjct: 2042 -------DLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVH 2094
Query: 470 MDYPHDNIEYYTSGG--PTTFAVDRLSGEVHLLGP--LDYEQQRLYRLTVLVIDHGQDQN 525
+ I Y G TF++ +G + + LD+E RL + Q
Sbjct: 2095 AGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVL--------QA 2146
Query: 526 PNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVE 568
+ +T+ ++D ND+AP P + P R +E
Sbjct: 2147 ESGGAFAFTVLTLTLQDANDNAPRFLRP--HYVAFLPESRPLE 2187
Score = 42.4 bits (98), Expect = 0.002
Identities = 38/137 (27%), Positives = 53/137 (38%), Gaps = 23/137 (16%)
Query: 451 RVQEDAAPHTLLGSV-----VGTDMDYPHDNIEYYTSGGPTTFAVDRLSGEVHLLGPLDY 505
++ E+ TL+G + GT + SG T A+D SG V LD
Sbjct: 50 QIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDR 109
Query: 506 EQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGR 565
EQ+ YR T + D + +T+ V D+NDHAP P + P
Sbjct: 110 EQRDRYRFTAVTPD-----------GATVEVTVRVADINDHAPAF--PQARAALQVP--- 153
Query: 566 SVEVTKMSCQIPQEPQR 582
E T + P EP R
Sbjct: 154 --EHTAFGTRYPLEPAR 168
>gi|169171663 PREDICTED: similar to hCG2036731 [Homo sapiens]
Length = 503
Score = 91.7 bits (226), Expect = 2e-18
Identities = 62/177 (35%), Positives = 91/177 (51%), Gaps = 12/177 (6%)
Query: 429 VPVLVMVTPINEFSP--ACAPRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGG-- 484
+ V+V V+ INE +P + + TF V E++ TL+G V TD D+P +N+EY GG
Sbjct: 247 ITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTVVGGNL 306
Query: 485 --PTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPN--HHLSGSCTITIEV 540
P F ++ +G + LL L+ E + Y++ V V D D P+ SG+ +TI V
Sbjct: 307 GTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISV 366
Query: 541 EDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNR 597
++ND P C PP E IY+ + S PQE SYSIVG ++R
Sbjct: 367 LNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEH----LSYSIVGEQDESR 419
>gi|239749177 PREDICTED: similar to hCG2036731 [Homo sapiens]
Length = 564
Score = 91.7 bits (226), Expect = 2e-18
Identities = 62/177 (35%), Positives = 91/177 (51%), Gaps = 12/177 (6%)
Query: 429 VPVLVMVTPINEFSP--ACAPRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGG-- 484
+ V+V V+ INE +P + + TF V E++ TL+G V TD D+P +N+EY GG
Sbjct: 247 ITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTVVGGNL 306
Query: 485 --PTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPN--HHLSGSCTITIEV 540
P F ++ +G + LL L+ E + Y++ V V D D P+ SG+ +TI V
Sbjct: 307 GTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISV 366
Query: 541 EDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNR 597
++ND P C PP E IY+ + S PQE SYSIVG ++R
Sbjct: 367 LNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEH----LSYSIVGEQDESR 419
>gi|239508938 PREDICTED: similar to hCG2036731 [Homo sapiens]
Length = 503
Score = 91.7 bits (226), Expect = 2e-18
Identities = 62/177 (35%), Positives = 91/177 (51%), Gaps = 12/177 (6%)
Query: 429 VPVLVMVTPINEFSP--ACAPRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGG-- 484
+ V+V V+ INE +P + + TF V E++ TL+G V TD D+P +N+EY GG
Sbjct: 247 ITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTVVGGNL 306
Query: 485 --PTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPN--HHLSGSCTITIEV 540
P F ++ +G + LL L+ E + Y++ V V D D P+ SG+ +TI V
Sbjct: 307 GTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISV 366
Query: 541 EDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNR 597
++ND P C PP E IY+ + S PQE SYSIVG ++R
Sbjct: 367 LNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEH----LSYSIVGEQDESR 419
>gi|169171173 PREDICTED: similar to hCG2036731 [Homo sapiens]
Length = 503
Score = 91.3 bits (225), Expect = 3e-18
Identities = 62/177 (35%), Positives = 91/177 (51%), Gaps = 12/177 (6%)
Query: 429 VPVLVMVTPINEFSP--ACAPRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGG-- 484
+ V+V V+ INE +P + + TF V E++ TL+G V TD D+P +N+EY GG
Sbjct: 247 ITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNL 306
Query: 485 --PTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPN--HHLSGSCTITIEV 540
P F ++ +G + LL L+ E + Y++ V V D D P+ SG+ +TI V
Sbjct: 307 GTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISV 366
Query: 541 EDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNR 597
++ND P C PP E IY+ + S PQE SYSIVG ++R
Sbjct: 367 LNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEH----LSYSIVGEQDESR 419
>gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]
Length = 1040
Score = 89.7 bits (221), Expect = 9e-18
Identities = 117/468 (25%), Positives = 200/468 (42%), Gaps = 47/468 (10%)
Query: 214 QRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD------LRY 267
Q+++ ++ ++VL + +F + +++PEN PG+ V+Q+ A D + Y
Sbjct: 228 QQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVY 287
Query: 268 EI---LSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNL 324
+SP LF + G + + L+ + V ++ V+A + G A +
Sbjct: 288 SFSSHISPRARELFGLSPRTGRLEVSGELDYEE---SPVYQVYVQAKDLGPNAVPAHCKV 344
Query: 325 TMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDS-----VGATLDYKLWFR 379
+ V N P + + + E A GTV+ + D DS V L + FR
Sbjct: 345 LVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFR 404
Query: 380 SSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPIN 439
S+ + Y V E A LD + A + +++ D G+P ++T + V V+ +N
Sbjct: 405 LKSSFKN--YYTIVTE--APLDRE---AGDSYTLTVVARDRGEPALSTSKSIQVQVSDVN 457
Query: 440 EFSPACAPRTF--RVQEDAAPHTLLGSVVGTDMD------YPHDNIEYYTSGGP--TTFA 489
+ +P + + V E+ P + +V TD D + +E G T +
Sbjct: 458 DNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVS 517
Query: 490 VDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPE 549
++ +G ++ L DYEQ + + V D G Q L+G+ T+ I + D ND+AP
Sbjct: 518 INSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQ----ALAGNATVNILIVDQNDNAPA 573
Query: 550 CEPPF---QELTIYAPLGRSVE----VTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQG 602
P L RS E +T+++ + + +YSIV GN N F +
Sbjct: 574 IVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDW 633
Query: 603 AILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLV 650
P + R YEL+I V D G P LS+TAT++V LV
Sbjct: 634 RTGELRTARRVPAKRDPQRPYELVIEVRDHG--QPPLSSTATLVVQLV 679
Score = 46.6 bits (109), Expect = 9e-05
Identities = 68/309 (22%), Positives = 117/309 (37%), Gaps = 36/309 (11%)
Query: 393 VLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPR--TF 450
VL VN +D + C Q + +L L+ V + V IN+ P+ T
Sbjct: 72 VLYVNEKIDREQ--ICKQSPSCVLHLEVFLENPLELFQVEIEVLDINDNPPSFPEPDLTV 129
Query: 451 RVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPTTFAVDRLS-------GEVHLLGPL 503
+ E A P T D D +++ Y + F++D + E+ L PL
Sbjct: 130 EISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNRFAELVLEKPL 189
Query: 504 DYEQQRLYRLTVLVIDHGQDQN--------------PNHHLSGSCTITIEVEDVNDHAPE 549
D EQQ ++R + +D G P +G+ +TI V D ND+ P
Sbjct: 190 DREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIRVLDSNDNVPA 249
Query: 550 CEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQ--RLIYSYSI-VGGNSQNRFILQ---GA 603
+ P +++ V +++ P E Q ++YS+S + ++ F L G
Sbjct: 250 FDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRARELFGLSPRTGR 309
Query: 604 ILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTHR 663
+ V +L E+ Y++ + D GP+ + V A ++ ST +
Sbjct: 310 LEVSGELDY-----EESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISFSTVK 364
Query: 664 TTVPSTMTP 672
V P
Sbjct: 365 EAVSEGAAP 373
>gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens]
Length = 896
Score = 89.7 bits (221), Expect = 9e-18
Identities = 117/468 (25%), Positives = 200/468 (42%), Gaps = 47/468 (10%)
Query: 214 QRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD------LRY 267
Q+++ ++ ++VL + +F + +++PEN PG+ V+Q+ A D + Y
Sbjct: 228 QQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVY 287
Query: 268 EI---LSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNL 324
+SP LF + G + + L+ + V ++ V+A + G A +
Sbjct: 288 SFSSHISPRARELFGLSPRTGRLEVSGELDYEE---SPVYQVYVQAKDLGPNAVPAHCKV 344
Query: 325 TMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDS-----VGATLDYKLWFR 379
+ V N P + + + E A GTV+ + D DS V L + FR
Sbjct: 345 LVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFR 404
Query: 380 SSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPIN 439
S+ + Y V E A LD + A + +++ D G+P ++T + V V+ +N
Sbjct: 405 LKSSFKN--YYTIVTE--APLDRE---AGDSYTLTVVARDRGEPALSTSKSIQVQVSDVN 457
Query: 440 EFSPACAPRTF--RVQEDAAPHTLLGSVVGTDMD------YPHDNIEYYTSGGP--TTFA 489
+ +P + + V E+ P + +V TD D + +E G T +
Sbjct: 458 DNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVS 517
Query: 490 VDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPE 549
++ +G ++ L DYEQ + + V D G Q L+G+ T+ I + D ND+AP
Sbjct: 518 INSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQ----ALAGNATVNILIVDQNDNAPA 573
Query: 550 CEPPF---QELTIYAPLGRSVE----VTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQG 602
P L RS E +T+++ + + +YSIV GN N F +
Sbjct: 574 IVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDW 633
Query: 603 AILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLV 650
P + R YEL+I V D G P LS+TAT++V LV
Sbjct: 634 RTGELRTARRVPAKRDPQRPYELVIEVRDHG--QPPLSSTATLVVQLV 679
Score = 46.6 bits (109), Expect = 9e-05
Identities = 68/309 (22%), Positives = 117/309 (37%), Gaps = 36/309 (11%)
Query: 393 VLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPR--TF 450
VL VN +D + C Q + +L L+ V + V IN+ P+ T
Sbjct: 72 VLYVNEKIDREQ--ICKQSPSCVLHLEVFLENPLELFQVEIEVLDINDNPPSFPEPDLTV 129
Query: 451 RVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPTTFAVDRLS-------GEVHLLGPL 503
+ E A P T D D +++ Y + F++D + E+ L PL
Sbjct: 130 EISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNRFAELVLEKPL 189
Query: 504 DYEQQRLYRLTVLVIDHGQDQN--------------PNHHLSGSCTITIEVEDVNDHAPE 549
D EQQ ++R + +D G P +G+ +TI V D ND+ P
Sbjct: 190 DREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIRVLDSNDNVPA 249
Query: 550 CEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQ--RLIYSYSI-VGGNSQNRFILQ---GA 603
+ P +++ V +++ P E Q ++YS+S + ++ F L G
Sbjct: 250 FDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRARELFGLSPRTGR 309
Query: 604 ILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTHR 663
+ V +L E+ Y++ + D GP+ + V A ++ ST +
Sbjct: 310 LEVSGELDY-----EESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISFSTVK 364
Query: 664 TTVPSTMTP 672
V P
Sbjct: 365 EAVSEGAAP 373
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 89.4 bits (220), Expect = 1e-17
Identities = 113/451 (25%), Positives = 185/451 (41%), Gaps = 37/451 (8%)
Query: 215 RQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVDL------RYE 268
++S ++ + V + F++ + ++ I E+ G+E++QV+AR DL Y
Sbjct: 810 QKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYS 869
Query: 269 ILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNV 328
+L+ F+I + G+V L+ + ++ E GQ S + L + +
Sbjct: 870 VLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSV-VTLKVFL 926
Query: 329 QLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPD-SVGATLDYKLWFRSSSNPASL 387
VN P +P+ ++ E PVGTV+ L DPD +G + Y L + +
Sbjct: 927 DDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSL-VNDYNGRFEI 985
Query: 388 CLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVP-VLVMVTPINE-----F 441
+ ++ LD + + ++ D G+P + V V V V +NE +
Sbjct: 986 DKASGAIRLSKELDYEKQQF---YNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPY 1042
Query: 442 SPACAPRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYT---SGGPTTFAVDRLSGEVH 498
P A V+E++ T + V D D D Y+ G F++D SG +
Sbjct: 1043 FPDFAV-VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVIT 1101
Query: 499 LLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELT 558
LD E Y LTV D G L + + IEVEDVND+AP P
Sbjct: 1102 AADILDRETMGSYWLTVYATDRGVVP-----LYSTIEVYIEVEDVNDNAPLTSEPIYYPV 1156
Query: 559 IYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSDLVL---GPF 615
+ + V V ++ + P +Y I GN QN F AI + + L+
Sbjct: 1157 VMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFF----AINIKTGLITTTSRKL 1212
Query: 616 WPEQPRTYELLICVADAGPSTPHLSTTATII 646
EQ + L + V D GPS P ST ++
Sbjct: 1213 DREQQAEHFLEVTVTDGGPS-PKQSTIWVVV 1242
Score = 85.1 bits (209), Expect = 2e-16
Identities = 111/481 (23%), Positives = 195/481 (40%), Gaps = 46/481 (9%)
Query: 203 VFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARG 262
V+ L + G + CQ + + + V + F N + EN A + + +VQA
Sbjct: 3098 VYSLMAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVD 3157
Query: 263 VDL---RYEILSPVPSP--LFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLW 317
D+ R + S S +FSI + G++ PL+ + S +S V+A +Q
Sbjct: 3158 PDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNIS---VRATDQSPGQ 3214
Query: 318 ASAKLN-LTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKL 376
+ + L +T+ V +N PP + +PE GT + + D +G +
Sbjct: 3215 SLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKD-IGTNAEITY 3273
Query: 377 WFRSSSNPASLCLYDRV--LEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVM 434
RS + + + + V+ LD + C + + DGG P ++ V +
Sbjct: 3274 LIRSGNEQGKFKINPKTGGISVSEVLDYEL---CKRFYLVVEAKDGGTPALSAVATVNIN 3330
Query: 435 VTPINEFSPACAPRTFR--VQEDAAPHTLLGSVVGTDMD-YPHDNIEYYTSGGP--TTFA 489
+T +N+ P + + + EDA + ++ D+D P+ I + G F
Sbjct: 3331 LTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFT 3390
Query: 490 VDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPE 549
VD + G V + LD E+ Y L V +D G +S + T+ I++ DVND++P
Sbjct: 3391 VDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPA-----MSSTATVNIDISDVNDNSPV 3445
Query: 550 CEPPFQELTIYA--PLGRSV---EVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAI 604
P I P+G S+ VT P +S+SI+ GN + F+L
Sbjct: 3446 FTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPP----FSFSILSGNEEEEFVLDPHG 3501
Query: 605 LVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTHRT 664
++ S +V + + E ++CV P + I R + STH+
Sbjct: 3502 ILRSAVVF-----QHTESLEYVLCVQAKDSGKPQQVSHTYI-------RVRVIEESTHKP 3549
Query: 665 T 665
T
Sbjct: 3550 T 3550
Score = 66.6 bits (161), Expect = 8e-11
Identities = 107/463 (23%), Positives = 182/463 (39%), Gaps = 66/463 (14%)
Query: 217 SCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD-------LRYEI 269
S +V V+V + + F ++ + E+ PG V + D + Y I
Sbjct: 2905 SSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHI 2964
Query: 270 LSPVPSPLFSIG--RADGVVRTTTPLE----------LARTSGTAVSRLQVKAFEQGQLW 317
P F++G +++ V PL+ + T G V++ V+
Sbjct: 2965 TGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQAMVE-------- 3016
Query: 318 ASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGAT--LDYK 375
++V VN P C + +PE P ++ ++ +D D +G+ + Y
Sbjct: 3017 --------VSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDAD-IGSNGYIRYS 3067
Query: 376 LWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMV 435
L + S ++ L L+ A LD + ++ DGG + + +++
Sbjct: 3068 L-YGSGNSEFFLDPESGELKTLALLDRERIPV---YSLMAKATDGGGRFCQSNIHLIL-- 3121
Query: 436 TPINEFSPACAPRTFR--VQEDAAPHTLLGSVVGTDMDYPHDNIEYYT----SGGPTTFA 489
+N+ P + + V E+ A LL V D D + Y+ +GG F+
Sbjct: 3122 EDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGG--VFS 3179
Query: 490 VDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPE 549
+D SG + L PLD EQQ Y ++V DQ+P LS T+TI V D+ND+ P
Sbjct: 3180 IDSSSGIIILEQPLDREQQSSYNISV----RATDQSPGQSLSSLTTVTITVLDINDNPPV 3235
Query: 550 CEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQ---GAILV 606
E +T+ +V + +Y I GN Q +F + G I V
Sbjct: 3236 FERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISV 3295
Query: 607 HSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHL 649
L E + + L++ D G TP LS AT+ ++L
Sbjct: 3296 SEVLDY-----ELCKRFYLVVEAKDGG--TPALSAVATVNINL 3331
Score = 65.9 bits (159), Expect = 1e-10
Identities = 96/400 (24%), Positives = 163/400 (40%), Gaps = 48/400 (12%)
Query: 179 GPFSINEQGWLQAPSQGLLGQAQKVFQLQISV---SFGQRQSCQGMVIVKVLPVPSSQVS 235
G FSI+ + Q L + Q + + + S GQ S V + VL + +
Sbjct: 3176 GVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPV 3235
Query: 236 FLEQAQNITIPENLAPGSEVVQVQARGVD------LRYEILSPVPSPLFSIGRADGVVRT 289
F + +T+PE+ +PG++V+ V A D + Y I S F I G +
Sbjct: 3236 FERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISV 3295
Query: 290 TTPL--ELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQI 347
+ L EL + L V+A + G SA + +N+ VN PP+ + + I
Sbjct: 3296 SEVLDYELCKR-----FYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVI 3350
Query: 348 PETAPVGTVLNTLTCEDPDS-VGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPG 406
E A VG + L ED DS + + + N ++ +++V LD +
Sbjct: 3351 SEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVS 3410
Query: 407 ACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFR--VQEDAAPHTLLGS 464
++ + +D G P M++ V + ++ +N+ SP P + +QE+ T +
Sbjct: 3411 G---YSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQ 3467
Query: 465 VVGTDMDYPHDNIEYYTSGGPTTFAVDRLSG---EVHLLGP---------LDYEQQRLYR 512
+V TD D H +G P +F++ LSG E +L P + + Y
Sbjct: 3468 LVVTDRDSFH-------NGPPFSFSI--LSGNEEEEFVLDPHGILRSAVVFQHTESLEYV 3518
Query: 513 LTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEP 552
L V D G+ Q +H I + V + + H P P
Sbjct: 3519 LCVQAKDSGKPQQVSH-----TYIRVRVIEESTHKPTAIP 3553
Score = 65.5 bits (158), Expect = 2e-10
Identities = 87/398 (21%), Positives = 172/398 (43%), Gaps = 37/398 (9%)
Query: 242 NITIPENLAPGSEVVQVQARGVD------LRYEILSPVPSPLFSIGRADGVVRTTTPLEL 295
++ + E+L G+ +++++A D + + I F+I G ++ P++
Sbjct: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDR 791
Query: 296 ARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGT 355
T + L + ++ G S+ LT+NV+ N P + I E++ +GT
Sbjct: 792 EHTD---LYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGT 848
Query: 356 VLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASI 415
+ + D D +G+ + + + ++ ++ V LD ++ +
Sbjct: 849 EIIQVEARDKD-LGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANYSLKIEAR 907
Query: 416 LVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTF--RVQEDAAPHTLLGSVVGTDMDYP 473
+ GQ Q+ + V + V + +N+ SPA P ++ +V ED T++ + D D
Sbjct: 908 DKAESGQ-QLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLG 966
Query: 474 HDNIEYYT--SGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLS 531
Y+ + F +D+ SG + L LDYE+Q+ Y LTV D G+ + LS
Sbjct: 967 LGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS----LS 1022
Query: 532 GSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYS----- 586
+ +EV DVN++ P F + +A +G E +++ + Q R S
Sbjct: 1023 SVSFVEVEVVDVNENLH--TPYFPD---FAVVGSVKENSRIGTSVLQVTARDEDSGRDGE 1077
Query: 587 --YSIVGGNSQNRFIL--QGAILVHSDLV----LGPFW 616
YSI G+ RF + + ++ +D++ +G +W
Sbjct: 1078 IQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYW 1115
Score = 64.3 bits (155), Expect = 4e-10
Identities = 93/373 (24%), Positives = 159/373 (42%), Gaps = 44/373 (11%)
Query: 204 FQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARG- 262
+ L + VS G+ S MV + V S + F + + +I EN ++V V A G
Sbjct: 1951 YMLIVKVSDGKFYSTS-MVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGN 2009
Query: 263 ---VDLRYEILSPVPSPLFSIGRADGVVRTT-TPLELARTSGTAVSRLQVKAFEQGQLWA 318
L+Y IL+P F I GV++TT P + + L V+A +
Sbjct: 2010 RLNEPLKYSILNP--GNKFKIKSTSGVIQTTGVPFDREEQE---LYELVVEASRELDHLR 2064
Query: 319 SAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDS-VGATLDYKLW 377
A++ + +N++ +N P + + + A GT++ +T D D + Y L
Sbjct: 2065 VARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQ 2124
Query: 378 -----FRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVL 432
F + N ++ L + N+ L + ++ +IL DGG+P ++T V +
Sbjct: 2125 DDYGHFEINPNSGNVILKEAF---NSDL------SNIEYGVTILAKDGGKPSLSTSVEL- 2174
Query: 433 VMVTPINEFSPACAPR--TFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGP-TTFA 489
+T +N+ P T V ED +T + S+ T + I G P F
Sbjct: 2175 -PITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE-GQGIIYIIIDGDPFKQFN 2232
Query: 490 VDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGS---CTITIEVEDVNDH 546
+D +G + ++ PLDYE Y+LT+ D L+G+ T+ + V DVND+
Sbjct: 2233 IDFDTGVLKVVSPLDYEVTSAYKLTIRASD---------ALTGARAEVTVDLLVNDVNDN 2283
Query: 547 APECEPPFQELTI 559
P + P T+
Sbjct: 2284 PPIFDQPTYNTTL 2296
Score = 63.9 bits (154), Expect = 5e-10
Identities = 76/360 (21%), Positives = 148/360 (41%), Gaps = 26/360 (7%)
Query: 199 QAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQV 258
+ + ++ + + V+ G + V +KVL + F + ++TI E++ P +E++Q+
Sbjct: 1424 EQRSIYNMSVEVTDGTNVAVT-QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQI 1482
Query: 259 QARGVDLRYEILSPVPSPL-------FSIGRADGVVRTTTPLELARTSGTAVSRLQVKAF 311
+A D ++++ V S + F I + GV+ T L+ L +
Sbjct: 1483 EATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLD---HEAQDKHILNIMVR 1539
Query: 312 EQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPD-SVGA 370
+Q + + +NV+ N P L + + E+A +G+ + +T D D A
Sbjct: 1540 DQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENA 1599
Query: 371 TLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVP 430
L Y + ++ N + ++ + D T G Q SI V D G P M+
Sbjct: 1600 ELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMG---QFVLSIKVTDQGSPPMSATAI 1656
Query: 431 VLVMVTPINEFSPACAPRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPTT--F 488
V + VT + P + + Q + + +G+ V + Y G F
Sbjct: 1657 VRISVTMSDNSHPKFIHKDY--QAEVNENVDIGTSVILISAISQSTLIYEVKDGDINGIF 1714
Query: 489 AVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAP 548
++ SG + LDYE+ Y+L + + ++ + T+ I++ D ND+AP
Sbjct: 1715 TINPYSGVITTQKALDYERTSSYQLIIQATNMA-------GMASNATVNIQIVDENDNAP 1767
Score = 62.0 bits (149), Expect = 2e-09
Identities = 46/176 (26%), Positives = 75/176 (42%), Gaps = 11/176 (6%)
Query: 431 VLVMVTPINEFSPACAPRTFRVQ--EDAAPHTLLGSVVGTDMDY-PHDNIEYYTSGGPTT 487
V + V +N+ P +P T+ V E T + V TD D + YY
Sbjct: 144 VNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDL 203
Query: 488 FAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHA 547
F+V SG + L G L+Y+++ Y L +L +D G N+ +S + + + +E +N+HA
Sbjct: 204 FSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHA 263
Query: 548 PECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRL---IYSYSIVGGNSQNRFIL 600
P + + P E T + I S SIV G+ ++F L
Sbjct: 264 PTI-----HVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFL 314
Score = 58.9 bits (141), Expect = 2e-08
Identities = 85/388 (21%), Positives = 167/388 (43%), Gaps = 38/388 (9%)
Query: 235 SFLEQAQNITIPENLAPGSEVVQVQARGVDL------RYEILSPVPSPLFSIGRADGVVR 288
+F+ + ++ + E+L G+ + ++ DL RY +++ + F I +A G +R
Sbjct: 935 AFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDY-NGRFEIDKASGAIR 993
Query: 289 TTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLV----NLWPPRCLPALLV 344
+ L+ + L V+A ++G+ + + ++ + V++V NL P +V
Sbjct: 994 LSKELDYEKQQ---FYNLTVRAKDKGRPVSLSSVSF-VEVEVVDVNENLHTPYFPDFAVV 1049
Query: 345 SQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDR--VLEVNATLDC 402
+ E + +GT + +T D DS G + + R S + D V+ LD
Sbjct: 1050 GSVKENSRIGTSVLQVTARDEDS-GRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDR 1108
Query: 403 DTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACA-PRTFRVQEDAAPHTL 461
+T G+ + ++ D G + + + V + V +N+ +P + P + V + +P +
Sbjct: 1109 ETMGSYW---LTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDV 1165
Query: 462 LGSVVGTDMDYP----HDNIEY-YTSGGPTTF-AVDRLSGEVHLLG-PLDYEQQRLYRLT 514
SV+ + P ++ + Y TSG P F A++ +G + LD EQQ + L
Sbjct: 1166 --SVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLE 1223
Query: 515 VLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAP--LGRSVEVTKM 572
V V D G + + + ++V D ND+ P+ ++ + R + +
Sbjct: 1224 VTVTDGGPSPKQS-----TIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRA 1278
Query: 573 SCQIPQEPQRLIYSYSIVGGNSQNRFIL 600
E SYSIV GN +F +
Sbjct: 1279 FAFDRDEGPNAEISYSIVDGNDDGKFFI 1306
Score = 56.2 bits (134), Expect = 1e-07
Identities = 101/497 (20%), Positives = 188/497 (37%), Gaps = 67/497 (13%)
Query: 181 FSIN-EQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGM--VIVKVLPVPSSQVSFL 237
F+IN + G + S+ L + Q L+++V+ G Q V+V+VL ++ F
Sbjct: 1196 FAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFP 1255
Query: 238 EQAQNITIPEN--LAPGSEVVQV------QARGVDLRYEILSPVPSPLFSIGRADGVVRT 289
E+ I +PE G + + + ++ Y I+ F I G+V +
Sbjct: 1256 EKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSS 1315
Query: 290 TTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALL------ 343
T+G+ L +KA + G+ S+ L +++ + PP +P
Sbjct: 1316 RKQF----TAGS-YDILTIKAVDNGRPQKSSTARL--HIEWIKKPPPSPIPLTFDEPFYN 1368
Query: 344 --VSQIPETAPVGTVLNTLTCEDP---DSVGATLDYKLWFRSSSNPASLCLYDRVLEVNA 398
V + + V++ P D VG D F + ++ +
Sbjct: 1369 FTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSA--FDAEKGVGTIV-------IAK 1419
Query: 399 TLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFRV--QEDA 456
LD + + S+ V DG +T V + V N+ P + + V ED
Sbjct: 1420 PLDAEQRSI---YNMSVEVTDGTNVAVTQ---VFIKVLDNNDNGPEFSQPNYDVTISEDV 1473
Query: 457 APHTLLGSVVGTDMDYPHDNIEYYTSGGPTT-----FAVDRLSGEVHLLGPLDYEQQRLY 511
P T + + TD D H + Y + F +D +G ++ LD+E Q +
Sbjct: 1474 LPDTEILQIEATDRDEKH-KLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKH 1532
Query: 512 RLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTK 571
L ++V D N + + VED NDH+P P E +++ V +
Sbjct: 1533 ILNIMVRDQEFPYRRN-----LARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQ 1587
Query: 572 MSCQIPQEPQRLIYSYSIVGGNSQNRFILQ---GAILVHSDLVLGPFWPEQPRTYELLIC 628
++ + + Y+I GN+ N F ++ G I + + P+ + ++
Sbjct: 1588 VTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE-------PDMTTMGQFVLS 1640
Query: 629 VADAGPSTPHLSTTATI 645
+ +P +S TA +
Sbjct: 1641 IKVTDQGSPPMSATAIV 1657
Score = 56.2 bits (134), Expect = 1e-07
Identities = 114/541 (21%), Positives = 210/541 (38%), Gaps = 57/541 (10%)
Query: 82 TLSSSAQLDALMVNHYKVQLKFTCGNHVMEGSLSVDVQRDLSHIQCAGQFASPAGEMIQV 141
T+ + LDA + Y + ++ T G +V + + V L + +F+ P + + +
Sbjct: 1414 TIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKV---LDNNDNGPEFSQPNYD-VTI 1469
Query: 142 PETVTPGARLYTLLLPGL-ELHGAQMSIISAQDLPHFPGPFSINEQGWLQAPSQGLLGQA 200
E V P + + E H ++ S+ D SI+ + + PS G+L A
Sbjct: 1470 SEDVLPDTEILQIEATDRDEKHKLSYTVHSSID--------SISMRKFRIDPSTGVLYTA 1521
Query: 201 QKVFQ-------LQISV---SFGQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLA 250
+++ L I V F R++ VIV V F ++ E+ A
Sbjct: 1522 ERLDHEAQDKHILNIMVRDQEFPYRRNL-ARVIVNVEDANDHSPYFTNPLYEASVFESAA 1580
Query: 251 PGSEVVQVQA------RGVDLRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVS 304
GS V+QV A +L Y I + +F I G++ ++ T G V
Sbjct: 1581 LGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMT-TMGQFV- 1638
Query: 305 RLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCED 364
L +K +QG SA + ++V + + P+ + +++ E +GT + ++
Sbjct: 1639 -LSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAIS 1697
Query: 365 PDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQ 424
+TL Y++ + ++ Y V+ LD + + +++
Sbjct: 1698 Q----STLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSY-----QLIIQATNMAG 1748
Query: 425 MTTEVPVLVMVTPINEFSPACAPRTFR--VQEDAAPHTLLGS-------VVGTDMDYPHD 475
M + V + + N+ +P + + E A ++++ S + TD D +
Sbjct: 1749 MASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRN 1808
Query: 476 NIEYYT---SGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSG 532
+ Y S F VD +G + + LD+E + V V D G +P
Sbjct: 1809 ALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSG---SPQLTAES 1865
Query: 533 SCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGG 592
+ IEV DVND+ P E + P VEV K+S P +YS++ G
Sbjct: 1866 PVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEG 1925
Query: 593 N 593
+
Sbjct: 1926 S 1926
Score = 53.9 bits (128), Expect = 6e-07
Identities = 78/339 (23%), Positives = 139/339 (41%), Gaps = 66/339 (19%)
Query: 331 VNLWPPRC-LPALLVSQ----IPETAPVGTVLNTLTCEDPDSVGATLDYKLWF------R 379
+++ PP LP+ SQ I E +G+ ++TL +V WF R
Sbjct: 2696 IHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNV--------WFSTVNGER 2747
Query: 380 SSSNPASLCLYDR---VLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVT 436
+N + + ++ ++++ LD +T A A+ + LD T +V + V+
Sbjct: 2748 PENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVL-- 2805
Query: 437 PINEFSPACAPRTFR--VQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPT-------T 487
+N+ P ++ + E T L V DMD+ + Y+ +
Sbjct: 2806 DLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEA 2865
Query: 488 FAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHA 547
F +D +G + L LD+E + +V+ D G+ + LS + +++ V D+ND+A
Sbjct: 2866 FNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFS----LSSTALVSVRVTDINDNA 2921
Query: 548 P------------ECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQ 595
P E +PP + + + + R + + ++ Q+ SY I GGN +
Sbjct: 2922 PVFAQEVYRGNVKESDPPGEVVAVLSTWDR--DTSDVNRQV---------SYHITGGNPR 2970
Query: 596 NRFILQGAILVHSD---LVLGPFWPEQPRTYELLICVAD 631
RF L LV S+ V P E+ Y L I D
Sbjct: 2971 GRFALG---LVQSEWKVYVKRPLDREEQDIYFLNITATD 3006
Score = 50.1 bits (118), Expect = 8e-06
Identities = 111/523 (21%), Positives = 205/523 (39%), Gaps = 76/523 (14%)
Query: 201 QKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQA 260
+ ++ L +SVS G S V ++VL +F + + EN+A G++V+ V+A
Sbjct: 2462 EPLYSLNVSVSDGLFTST-AQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRA 2520
Query: 261 RGVD------LRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQG 314
D + Y I++ F I ++G V TT L+ VS + V+A + G
Sbjct: 2521 TDGDPGTYGQISYAIINDFAKDRFLID-SNGQVITTERLDRENPLEGDVS-IFVRALDGG 2578
Query: 315 QLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDS-VGATLD 373
+ + + + N P+ + + + G ++ + DPD + +
Sbjct: 2579 GRTTFCTVRVIVVDENDNA--PQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRIT 2636
Query: 374 YKLWFRSSSNPASLCLYD-----RVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTE 428
Y L+ +S + A L D V + N +T + F A +DGG P +
Sbjct: 2637 YSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKA-----VDGGIPVKHSL 2691
Query: 429 VPVLVMVTPINEFSPAC--APRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPT 486
+PV + V P F P+ + +F + ED T +GS V T P N+ + T G
Sbjct: 2692 IPVYIHVLPPETFLPSFTQSQYSFTIAED----TAIGSTVDTLRILPSQNVWFSTVNGER 2747
Query: 487 -------TFAVDRLSGEVHLLGPLDYEQQRLYRLTV---LVIDHGQDQNPNHHLSGSCTI 536
F +++ +G + L LD E + V + +D + + +
Sbjct: 2748 PENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLD-------KVDIVFTVDV 2800
Query: 537 TIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKM---------------SCQIPQEPQ 581
I+V D+ND+ P E + I + ++T++ S +P+
Sbjct: 2801 DIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPE 2860
Query: 582 RLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLST 641
+++ +++I +S +I L H E T+ + +D G + LS+
Sbjct: 2861 KVMEAFNI---DSNTGWISTLKDLDH----------ETDPTFTFSVVASDLGEAF-SLSS 2906
Query: 642 TATIIVHL--VPRRASTVATSTHRTTVPSTMTPMLVTDTEAFW 682
TA + V + + A A +R V + P V + W
Sbjct: 2907 TALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTW 2949
Score = 48.9 bits (115), Expect = 2e-05
Identities = 88/372 (23%), Positives = 150/372 (40%), Gaps = 37/372 (9%)
Query: 236 FLEQAQNITIPENLAPGSEVVQVQARGVD------LRYEILSPV--PSPLFSIGRADGVV 287
F + N T+ E G+ V+QV + D + Y+I+ + F I + G++
Sbjct: 2287 FDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLI 2346
Query: 288 RTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQI 347
T L+ L+V++ + G S+++ + + + VN PP + S +
Sbjct: 2347 LTARMLDHELVQHCT---LKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYV 2403
Query: 348 PETAPVGTVLNTLTCEDPDSVGAT-LDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPG 406
E AP G + + D DS L+Y + S N + L D V +
Sbjct: 2404 SELAPRGHFVTCVQASDADSSDFDRLEYSIL---SGNDRTSFLMDSKSGVITLSNHRKQR 2460
Query: 407 ACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTF--RVQEDAAPHTLLGS 464
++ ++ V DG T+ V + V N +SPA + T+ V+E+ A T +
Sbjct: 2461 MEPLYSLNVSVSDG---LFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIH 2517
Query: 465 VVGTDMDY-PHDNIEYYTSGGPTTFAVDRL----SGEVHLLGPLDYEQQRLYRLTVLV-- 517
V TD D + I Y FA DR +G+V LD E +++ V
Sbjct: 2518 VRATDGDPGTYGQISYAIIND---FAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRA 2574
Query: 518 IDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIP 577
+D G CT+ + V D ND+AP+ ++ A +GR VT++ P
Sbjct: 2575 LDGGGRTT-------FCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDP 2627
Query: 578 QEPQRLIYSYSI 589
+ +YS+
Sbjct: 2628 DDGANSRITYSL 2639
Score = 45.1 bits (105), Expect = 3e-04
Identities = 49/215 (22%), Positives = 96/215 (44%), Gaps = 17/215 (7%)
Query: 234 VSFLEQAQNITIPENLAPGSEV--VQVQARGVDLRYEILSPVPSPLFSIGRADGVVRTTT 291
+ F ++ +++I E PG V V++ +D+ Y++ + F I G++ T
Sbjct: 374 IRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTAR 433
Query: 292 PLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETA 351
PL + V +L+V ++G L K +T++++ N P L + + E+
Sbjct: 434 PLNTVKKE---VYKLEVTN-KEGDL----KAQVTISIEDANDHTPEFQQPLYDAYVNESV 485
Query: 352 PVGTVLNTLTCEDPDSVGATLDYKLWFRSSSN--PASLCLYDRVLEVNATLDCDTPGACF 409
PVGT + T++ D D Y + +S N P + + V+ LD ++ +
Sbjct: 486 PVGTSVLTVSASDKDK--GENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIY 543
Query: 410 QHAASILVLDGGQP-QMTTEVPVLVMVTPINEFSP 443
+ + D G P + +EV V + + +N+ SP
Sbjct: 544 RFI--VRASDWGSPYRHESEVNVTIRIGNVNDNSP 576
Score = 40.8 bits (94), Expect = 0.005
Identities = 85/440 (19%), Positives = 160/440 (36%), Gaps = 44/440 (10%)
Query: 222 VIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVDLR------YEILSPVPS 275
V ++VL + + F ++TI E+ + V QV A D+ Y + V
Sbjct: 144 VNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD- 202
Query: 276 PLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQ--GQLWASAKLNLTMNVQLVNL 333
LFS+ GV+ + L + + L V + G S+ L ++++ +N
Sbjct: 203 -LFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINE 261
Query: 334 WPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRV 393
P +V+ +P + +T +D D GA + + + +P +
Sbjct: 262 HAPTIH---VVTHVPFSLEKEPTYAVVTVDDLDD-GANGEIESVSIVAGDPLDQFFLAKE 317
Query: 394 ------LEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAP 447
++ D + + ++ D G PQ + + + + P + P
Sbjct: 318 GKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFE 377
Query: 448 RTF---RVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPTT--FAVDRLSGEVHLLGP 502
+ + E + P ++ V + ++EY S G F ++ SG + P
Sbjct: 378 KEVYDVSISEFSPPGVVVAIV---KLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARP 434
Query: 503 LDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAP 562
L+ ++ +Y+L V N +TI +ED NDH PE + P + +
Sbjct: 435 LNTVKKEVYKLEVT----------NKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNES 484
Query: 563 LGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQ--GAILVHSDLVLGPFWPEQP 620
+ V +S + + +YSI N I Q G I +L + P
Sbjct: 485 VPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEEL----DFESSP 540
Query: 621 RTYELLICVADAGPSTPHLS 640
Y ++ +D G H S
Sbjct: 541 EIYRFIVRASDWGSPYRHES 560
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 88.6 bits (218), Expect = 2e-17
Identities = 90/347 (25%), Positives = 151/347 (43%), Gaps = 27/347 (7%)
Query: 336 PRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGA-TLDYKL--WFRSSSNPA-SLCLYD 391
P+ P + +PE P GT + +L DPD A L+Y + F S SN SL
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 392 RVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFR 451
+ LD +T H + D G P+ + + ++VT N+ P + ++
Sbjct: 239 GAVTTAEELDRETKST---HVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYK 295
Query: 452 --VQEDAAPHTLLGSVVGTDMDYPHD-NIEYY----TSGGPT-TFAVDRLSGEVHLLGPL 503
++E+ + +V TD D P + NI Y + G P+ F +D SG + GP+
Sbjct: 296 ESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
Query: 504 DYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPL 563
D E+ Y+LTV D G+D P S + + + VED ND+AP+ + + +
Sbjct: 356 DREEVESYQLTVEASDQGRDPGPR---STTAAVFLSVEDDNDNAPQFSEKRYVVQVREDV 412
Query: 564 GRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQ---GAILVHSDLVLGPFWPEQP 620
V +++ + + YSI+ GN++ +F L GA+ V+ P E
Sbjct: 413 TPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGAL-----DVVSPLDYETT 467
Query: 621 RTYELLICVADAG-PSTPHLSTTATIIVHLVPRRASTVATSTHRTTV 666
+ Y L + D G P ++S T+ V + A ++ + TV
Sbjct: 468 KEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATV 514
Score = 80.1 bits (196), Expect = 7e-15
Identities = 121/502 (24%), Positives = 203/502 (40%), Gaps = 53/502 (10%)
Query: 215 RQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD------LRYE 268
R+S + + V F +Q ++ ENL G EV+ V+A D + Y
Sbjct: 268 RRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYR 327
Query: 269 ILSPV---PSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWA--SAKLN 323
+L PS +F I GV+RT P++ +L V+A +QG+ S
Sbjct: 328 LLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESY---QLTVEASDQGRDPGPRSTTAA 384
Query: 324 LTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDS-VGATLDYKLWFRSSS 382
+ ++V+ N P+ V Q+ E G + +T D D A + Y + ++
Sbjct: 385 VFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNAR 444
Query: 383 NPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVP-VLVMVTPINEF 441
L L+V + LD +T ++ + DGG+P ++ V V V IN+
Sbjct: 445 GQFYLDAQTGALDVVSPLDYETTK---EYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDN 501
Query: 442 SPACAPRTFR--VQEDAAPHTLLGSVVGTDMDYPHD-NIEYYTSG--GPTTFAVDRLSGE 496
+P F+ V E L+ V D D + +EY +G F ++ +G
Sbjct: 502 APIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGW 561
Query: 497 VHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQE 556
+ + LD E+ Y V DHG L+ S ++++ V DVND+ P P E
Sbjct: 562 ISVAAELDREEVDFYSFGVEARDHGTPA-----LTASASVSVTVLDVNDNNPTFTQP--E 614
Query: 557 LTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFIL---QGAILVHSDLVLG 613
T+ +V + ++ + +Y I GN++NRF + G LV L
Sbjct: 615 YTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLAL--- 671
Query: 614 PFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTHRTTVPSTMTPM 673
P + R Y L + +D TA I+V++ +THR S+ +
Sbjct: 672 PLDYKLERQYVLAVTASDG-----TRQDTAQIVVNVTD-------ANTHRPVFQSSHYTV 719
Query: 674 LVTDTEAFWQPQPWFVVVLTAT 695
V + +P VV+++AT
Sbjct: 720 NVNED----RPAGTTVVLISAT 737
Score = 74.7 bits (182), Expect = 3e-13
Identities = 121/499 (24%), Positives = 186/499 (37%), Gaps = 60/499 (12%)
Query: 180 PFSINE-QGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGM--------VIVKVLPVP 230
PF+IN GW+ ++ L + + F SFG G V V VL V
Sbjct: 552 PFTINNGTGWISVAAE--LDREEVDFY-----SFGVEARDHGTPALTASASVSVTVLDVN 604
Query: 231 SSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD----LRYEILSPVPSPLFSIGRADG- 285
+ +F + + + E+ A G+ VV V A D + Y+I S FSI G
Sbjct: 605 DNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGG 664
Query: 286 -VVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLV 344
+V PL+ + R V A + +NV N P +
Sbjct: 665 GLVSLALPLDYK------LERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYT 718
Query: 345 SQIPETAPVGTVLNTLTCEDPDS-VGATLDYKLWFRSSSNPASLCLYDR-VLEVNATLDC 402
+ E P GT + ++ D D+ A + Y F S P D + A LD
Sbjct: 719 VNVNEDRPAGTTVVLISATDEDTGENARITY---FMEDSIPQFRIDADTGAVTTQAELDY 775
Query: 403 DTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFR--VQEDAAPHT 460
+ + +I D G PQ + + ++V +N+ +P +++ V ED P T
Sbjct: 776 EDQ---VSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFT 832
Query: 461 LLGSVVGTDMDYPHDNIEYYT----SGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVL 516
+ + TD D + +YT G F V+ SG V L LD E Y L
Sbjct: 833 SVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAY 892
Query: 517 VIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQI 576
+D G +T+ V DVND+ P E ++ + + V +++
Sbjct: 893 AVDKGMPPART-----PMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATD 947
Query: 577 PQEPQRLIYSYSIVGGNSQNRF---ILQGAILVHSDLVLGPFWPEQPRTYELLICVADAG 633
P E Y IV GN F I G + DL + R +L+ A +
Sbjct: 948 PDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDL------DYEDRPEYVLVIQATSA 1001
Query: 634 PSTPHLSTTATIIVHLVPR 652
P L + AT+ V L+ R
Sbjct: 1002 P----LVSRATVHVRLLDR 1016
Score = 71.6 bits (174), Expect = 3e-12
Identities = 102/424 (24%), Positives = 173/424 (40%), Gaps = 26/424 (6%)
Query: 138 MIQVPETVTPGARLYTLLLPGLELHGAQMSIISAQDLPHFPGPFSINEQGWLQAPSQGLL 197
++QV E VTPGA + + + G+ + + + G F ++ Q L
Sbjct: 405 VVQVREDVTPGAPVLRVTASDRD-KGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLD 463
Query: 198 GQAQKVFQLQISVSFGQR---QSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSE 254
+ K + L++ G R + G+V V+VL + + F+ T+ E++ G
Sbjct: 464 YETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYL 523
Query: 255 VVQVQARGVD------LRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQV 308
V+ VQA D L Y + F+I G + L+ + V
Sbjct: 524 VLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFG---V 580
Query: 309 KAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSV 368
+A + G +A ++++ V VN P ++ E A VGT + T++ D D+
Sbjct: 581 EARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA- 639
Query: 369 GATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTE 428
+ + Y++ ++ N S+ V+ L D Q+ ++ DG + Q T +
Sbjct: 640 HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLER-QYVLAVTASDGTR-QDTAQ 697
Query: 429 VPVLVMVTPINEFSPA--CAPRTFRVQEDAAPHTLLGSVVGTDMDYPHD-NIEYYTSGGP 485
+ +V VT N P + T V ED T + + TD D + I Y+
Sbjct: 698 I--VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSI 755
Query: 486 TTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVND 545
F +D +G V LDYE Q Y L + D+G Q S + + I V DVND
Sbjct: 756 PQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQK-----SDTTYLEILVNDVND 810
Query: 546 HAPE 549
+AP+
Sbjct: 811 NAPQ 814
Score = 54.7 bits (130), Expect = 3e-07
Identities = 94/380 (24%), Positives = 145/380 (38%), Gaps = 26/380 (6%)
Query: 181 FSINEQ--GWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLE 238
FSI Q G L + + L + ++ + L ++ S G RQ ++V V + + F
Sbjct: 656 FSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT-AQIVVNVTDANTHRPVFQS 714
Query: 239 QAQNITIPENLAPGSEVVQVQAR----GVDLRYEILSPVPSPLFSIGRADGVVRTTTPLE 294
+ + E+ G+ VV + A G + R P F I G V T L+
Sbjct: 715 SHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELD 774
Query: 295 LA-RTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPV 353
+ S T L + A + G S L + V VN P+ L + E P
Sbjct: 775 YEDQVSYT----LAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP 830
Query: 354 GTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAA 413
T + ++ D DS G F+ + + + + TL Q+
Sbjct: 831 FTSVLQISATDRDS-GLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVL 889
Query: 414 SILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFRV--QEDAAPHTLLGSVVGTDMD 471
+D G P T + V V V +N+ P F V +E++ + V TD D
Sbjct: 890 RAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPD 949
Query: 472 Y-PHDNIEYYTSGG--PTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNH 528
+ I Y G P F +D SGE+ L LDYE + Y VLVI Q +
Sbjct: 950 EGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY---VLVI-----QATSA 1001
Query: 529 HLSGSCTITIEVEDVNDHAP 548
L T+ + + D ND+ P
Sbjct: 1002 PLVSRATVHVRLLDRNDNPP 1021
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 88.6 bits (218), Expect = 2e-17
Identities = 116/426 (27%), Positives = 185/426 (43%), Gaps = 38/426 (8%)
Query: 245 IPENLAPGSEVVQVQARGVD------LRYEILSPVPS---PLFSIGRADGVVRTTTPLEL 295
+PEN A G+ V++V A+ D L Y + + + S LFSI G++RT L+
Sbjct: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALD- 392
Query: 296 ARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGT 355
L+V A + G SA + + V N P A + E G
Sbjct: 393 --RESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGY 450
Query: 356 VLNTLTCEDPDSV-GATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAAS 414
+ L D D+ A L Y+ ++ A+ ++ ++ + L + +H S
Sbjct: 451 PILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE--IDPRSGLISTSGRVDREHMES 508
Query: 415 ILVL----DGGQPQMTTEVPVLVMVTPI--NEFSPACAPRTF--RVQEDAAPHTLLGSVV 466
++ D GQ V V +T + N+ +P + + + +V+ED PHT++ V
Sbjct: 509 YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVT 568
Query: 467 GTDMDYPHDNIEYYT--SGGPTT-FAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQD 523
TD D + + +Y SG FA+D L+GE+ ++ PLD+E +R Y L + D G+
Sbjct: 569 ATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRP 628
Query: 524 QNPNHHLSGSCTITIEVEDVNDHAP-ECEPPFQELTI-YAPLGRSVEVTKMSCQIPQEPQ 581
N+ + +I+V D+NDH P PFQ + APLG SV + E
Sbjct: 629 PLSNN----TGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENA 684
Query: 582 RLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLST 641
RL YS+ G F++ A S V GP E Y + D G +P LS
Sbjct: 685 RL--EYSLTGVAPDTPFVINSATGWVS--VSGPLDRESVEHYFFGVEARDHG--SPPLSA 738
Query: 642 TATIIV 647
+A++ V
Sbjct: 739 SASVTV 744
Score = 74.7 bits (182), Expect = 3e-13
Identities = 88/363 (24%), Positives = 144/363 (39%), Gaps = 25/363 (6%)
Query: 199 QAQKVFQLQISVSFGQRQSCQ---GMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEV 255
+A++ + L+I R G+ ++V+ + F+ +++ EN G V
Sbjct: 611 EAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670
Query: 256 VQVQARGVD------LRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVK 309
+ +QA D L Y + P F I A G V + PL+ V+
Sbjct: 671 IHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG---VE 727
Query: 310 AFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVG 369
A + G SA ++T+ V VN P ++ E A VGT + ++T D D+
Sbjct: 728 ARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANS 787
Query: 370 ATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEV 429
A + Y++ ++ N ++ V V L D Q LVL +
Sbjct: 788 A-ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK----QERYFKLVLTASDRALHDHC 842
Query: 430 PVLVMVTPINEFSPA--CAPRTFRVQEDAAPHTLLGSVVGTDMDYPHD-NIEYYTSGGPT 486
V + +T N P A + V ED + + + +D D + I Y
Sbjct: 843 YVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLP 902
Query: 487 TFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDH 546
F +D SG + L PLDYE Q Y L + D+G Q + + + + V DVND+
Sbjct: 903 QFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQK-----ADTTYVEVMVNDVNDN 957
Query: 547 APE 549
AP+
Sbjct: 958 APQ 960
Score = 74.7 bits (182), Expect = 3e-13
Identities = 115/458 (25%), Positives = 177/458 (38%), Gaps = 58/458 (12%)
Query: 217 SCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD----LRYEILSP 272
S V V VL V ++ F + ++ + E+ A G+ VV V A D + Y+I
Sbjct: 737 SASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGG 796
Query: 273 VPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVN 332
F+I GV T L L +L + A ++ + +N+ N
Sbjct: 797 NTRNRFAISTQGGVGLVTLALPLDYKQ-ERYFKLVLTASDRA---LHDHCYVHINITDAN 852
Query: 333 LWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPD-SVGATLDYKL-----WFRSSSNPAS 386
P A + E P+G+ + ++ D D A + Y L FR ++ +
Sbjct: 853 THRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGA 912
Query: 387 LCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSP--A 444
+ L A LD + + +I D G PQ V VMV +N+ +P
Sbjct: 913 ITL-------QAPLDYEDQ---VTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFV 962
Query: 445 CAPRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYT----SGGPTTFAVDRLSGEVHLL 500
+ T V EDA P T + + TD D + YT G F ++ SG V +
Sbjct: 963 ASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV 1022
Query: 501 GPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAP-----ECEPPFQ 555
LD E +Y LT +D G L +I + V+DVND+AP E E +
Sbjct: 1023 RRLDREAVSVYELTAYAVDRGVPP-----LRTPVSIQVMVQDVNDNAPVFPAEEFEVRVK 1077
Query: 556 ELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRF---ILQGAILVHSDLVL 612
E +I + V +++ P E Y IV GN F I G + DL
Sbjct: 1078 ENSIVGSV-----VAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDL-- 1130
Query: 613 GPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLV 650
+ R +++ A + P L + AT+ V LV
Sbjct: 1131 ----DYEARQEYVIVVQATSAP----LVSRATVHVRLV 1160
>gi|14165405 protocadherin alpha 2 isoform 2 precursor [Homo
sapiens]
Length = 824
Score = 88.2 bits (217), Expect = 3e-17
Identities = 121/514 (23%), Positives = 208/514 (40%), Gaps = 58/514 (11%)
Query: 222 VIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD------LRYEILSPVPS 275
+++KVL V ++ +F + + + EN A G+ VV++ A D + Y + S V S
Sbjct: 228 ILIKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSS 287
Query: 276 PL---FSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVN 332
+ F+I G +RT L+ + QV A ++G S +++ + +N
Sbjct: 288 TIQTKFTIDPISGEIRTKGKLDYEEAKSYEI---QVTATDKGTPSMSGHCKISLKLVDIN 344
Query: 333 LWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDS-----VGATLDYKLWFRSSSNPASL 387
P L I E A +GTV+ +T D DS V +L + F+ S +
Sbjct: 345 DNTPEVSITSLSLPISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNY 404
Query: 388 CLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAP 447
Y VL+ + LD ++ A + + DGG P + V + V +N+ +PA A
Sbjct: 405 --YSLVLD--SALDRESVSA---YELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQ 457
Query: 448 RTFRV--QEDAAPHTLLGSVVGTDMDYPHDNIEYYT--------SGGPTTFAVDRLSGEV 497
+ V +E+ P + +V D D + + Y+ + +V SG+V
Sbjct: 458 PEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKV 517
Query: 498 HLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPP---- 553
+ L PLD+E+ L + V D G L + T+ + V D ND+AP P
Sbjct: 518 YALQPLDHEEVELLQFQVSARDAGVPP-----LGSNVTLQVFVLDENDNAPALLAPRAGT 572
Query: 554 ----FQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSD 609
EL ++ +G V K+ SY + G R + +
Sbjct: 573 AAGAVSELVPWS-VGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFRVGLYTGEI 631
Query: 610 LVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTHRTTVPST 669
+ LL+ V D G P L+ TAT++V LV + A+S R V +
Sbjct: 632 STTRALDEADSPRHRLLVLVKDHG--EPALTATATVLVSLVESGQAPKASS--RAWVGAA 687
Query: 670 MTPMLVTDTEAFWQPQPWFVVVLTATGALLLLAL 703
+ + D + ++ + A +LL+L +
Sbjct: 688 GSEATLVDVNVY------LIIAICAVSSLLVLTV 715
Score = 81.6 bits (200), Expect = 3e-15
Identities = 76/294 (25%), Positives = 126/294 (42%), Gaps = 51/294 (17%)
Query: 415 ILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQ--EDAAPHTLLGSVVGTDMDY 472
++ DGG+P++T V +L+ V +N+ P A ++V+ E+ A TL+ + +D D
Sbjct: 212 LVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDADE 271
Query: 473 -PHDNIEY-----YTSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNP 526
P+ I Y +S T F +D +SGE+ G LDYE+ + Y + V D G
Sbjct: 272 GPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTATDKGTPS-- 329
Query: 527 NHHLSGSCTITIEVEDVNDHAPECEPPFQELTI--YAPLGRSVEVTKMS----------- 573
+SG C I++++ D+ND+ PE L I A LG + + +S
Sbjct: 330 ---MSGHCKISLKLVDINDNTPEVSITSLSLPISENASLGTVIALITVSDRDSGTNGHVT 386
Query: 574 CQI-PQEPQRLIYS----YSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPRTYELLIC 628
C + P P +L+ + YS+V ++ +R E YEL++
Sbjct: 387 CSLTPHVPFKLVSTFKNYYSLVLDSALDR--------------------ESVSAYELVVT 426
Query: 629 VADAGPSTPHLSTTATIIVHLVPRRASTVATSTHRTTVPSTMTPMLVTDTEAFW 682
D G + +T+ +I V V A A + V P T + W
Sbjct: 427 ARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW 480
>gi|9256584 protocadherin alpha 2 isoform 1 precursor [Homo sapiens]
Length = 948
Score = 88.2 bits (217), Expect = 3e-17
Identities = 121/514 (23%), Positives = 208/514 (40%), Gaps = 58/514 (11%)
Query: 222 VIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD------LRYEILSPVPS 275
+++KVL V ++ +F + + + EN A G+ VV++ A D + Y + S V S
Sbjct: 228 ILIKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSS 287
Query: 276 PL---FSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVN 332
+ F+I G +RT L+ + QV A ++G S +++ + +N
Sbjct: 288 TIQTKFTIDPISGEIRTKGKLDYEEAKSYEI---QVTATDKGTPSMSGHCKISLKLVDIN 344
Query: 333 LWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDS-----VGATLDYKLWFRSSSNPASL 387
P L I E A +GTV+ +T D DS V +L + F+ S +
Sbjct: 345 DNTPEVSITSLSLPISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNY 404
Query: 388 CLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAP 447
Y VL+ + LD ++ A + + DGG P + V + V +N+ +PA A
Sbjct: 405 --YSLVLD--SALDRESVSA---YELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQ 457
Query: 448 RTFRV--QEDAAPHTLLGSVVGTDMDYPHDNIEYYT--------SGGPTTFAVDRLSGEV 497
+ V +E+ P + +V D D + + Y+ + +V SG+V
Sbjct: 458 PEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKV 517
Query: 498 HLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPP---- 553
+ L PLD+E+ L + V D G L + T+ + V D ND+AP P
Sbjct: 518 YALQPLDHEEVELLQFQVSARDAGVPP-----LGSNVTLQVFVLDENDNAPALLAPRAGT 572
Query: 554 ----FQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSD 609
EL ++ +G V K+ SY + G R + +
Sbjct: 573 AAGAVSELVPWS-VGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFRVGLYTGEI 631
Query: 610 LVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTHRTTVPST 669
+ LL+ V D G P L+ TAT++V LV + A+S R V +
Sbjct: 632 STTRALDEADSPRHRLLVLVKDHG--EPALTATATVLVSLVESGQAPKASS--RAWVGAA 687
Query: 670 MTPMLVTDTEAFWQPQPWFVVVLTATGALLLLAL 703
+ + D + ++ + A +LL+L +
Sbjct: 688 GSEATLVDVNVY------LIIAICAVSSLLVLTV 715
Score = 81.6 bits (200), Expect = 3e-15
Identities = 76/294 (25%), Positives = 126/294 (42%), Gaps = 51/294 (17%)
Query: 415 ILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQ--EDAAPHTLLGSVVGTDMDY 472
++ DGG+P++T V +L+ V +N+ P A ++V+ E+ A TL+ + +D D
Sbjct: 212 LVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDADE 271
Query: 473 -PHDNIEY-----YTSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNP 526
P+ I Y +S T F +D +SGE+ G LDYE+ + Y + V D G
Sbjct: 272 GPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTATDKGTPS-- 329
Query: 527 NHHLSGSCTITIEVEDVNDHAPECEPPFQELTI--YAPLGRSVEVTKMS----------- 573
+SG C I++++ D+ND+ PE L I A LG + + +S
Sbjct: 330 ---MSGHCKISLKLVDINDNTPEVSITSLSLPISENASLGTVIALITVSDRDSGTNGHVT 386
Query: 574 CQI-PQEPQRLIYS----YSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPRTYELLIC 628
C + P P +L+ + YS+V ++ +R E YEL++
Sbjct: 387 CSLTPHVPFKLVSTFKNYYSLVLDSALDR--------------------ESVSAYELVVT 426
Query: 629 VADAGPSTPHLSTTATIIVHLVPRRASTVATSTHRTTVPSTMTPMLVTDTEAFW 682
D G + +T+ +I V V A A + V P T + W
Sbjct: 427 ARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW 480
>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
Length = 794
Score = 87.0 bits (214), Expect = 6e-17
Identities = 94/358 (26%), Positives = 151/358 (42%), Gaps = 35/358 (9%)
Query: 223 IVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD---------LRYEILSPV 273
I+KV + ++ FL+ T+PE G+ V+QV+A D + Y IL
Sbjct: 147 IIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQG- 205
Query: 274 PSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAF--EQGQLWASAKLNLTMNVQLV 331
P FSI GV+RT P +Q K + G L + +N+T+ V
Sbjct: 206 -QPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTD--V 262
Query: 332 NLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPD-SVGATLDYKLWFRSSSNPASLC-- 388
N PPR ++ ++PE++P+G+ + + DPD A ++Y + N +
Sbjct: 263 NDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTD 322
Query: 389 --LYDRVLEVNATLDCDTPGA-CFQHAASILVLD----GGQPQMTTEVPVLVMVTPINEF 441
+ V+++ LD +T A F+ AS L LD P T V + V ++E
Sbjct: 323 EDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDT-ATVKISVLDVDEP 381
Query: 442 SPACAP-RTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYY---TSGGPTTFAVDRLSGEV 497
P T V ED T++G+V D+D + Y+ S G + F +D G +
Sbjct: 382 PVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTI 441
Query: 498 HLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQ 555
LD E Y +++ + N L+ I I V DVN+ PE P++
Sbjct: 442 ATNELLDRESTAQYNFSIIA-----SKVSNPLLTSKVNILINVLDVNEFPPEISVPYE 494
Score = 42.7 bits (99), Expect = 0.001
Identities = 24/84 (28%), Positives = 43/84 (51%), Gaps = 6/84 (7%)
Query: 468 TDMDYPHDNIEYYTSG--GPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQN 525
+D+D ++Y SG T F +D +G++H + LD E++ Y L +D + +
Sbjct: 80 SDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDI-ETRK 138
Query: 526 PNHHLSGSCTITIEVEDVNDHAPE 549
P L I+V+D+ND+ P+
Sbjct: 139 P---LEPESEFIIKVQDINDNEPK 159
>gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens]
Length = 781
Score = 87.0 bits (214), Expect = 6e-17
Identities = 114/451 (25%), Positives = 180/451 (39%), Gaps = 39/451 (8%)
Query: 223 IVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD---------LRYEILSPV 273
I+KV + + F + T+PE G+ V+QV A D L Y +L +
Sbjct: 137 IIKVQDINDNPPIFPLGPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGL 196
Query: 274 PSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNL 333
P FS+ GVVRT P T + +Q K S +T+ + VN
Sbjct: 197 P--FFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVND 254
Query: 334 WPPRCLPALLVSQIPETAPVGTVLNTLTCEDPD-SVGATLDYKLWFRSSSNPASLCL--- 389
PP+ +L + ETA GT++ L +DPD A + Y + S S+
Sbjct: 255 NPPKFPQSLYQFSVVETAGPGTLVGRLRAQDPDLGDNALMAYSILDGEGSEAFSISTDLQ 314
Query: 390 -YDRVLEVNATLDCDTPGA-CFQHAASILVLD-----GGQPQMTTEVPVLVMVTPINEFS 442
D +L V LD ++ + F+ A+ ++D G + V V V P
Sbjct: 315 GRDGLLTVRKPLDFESQRSYSFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAP---EP 371
Query: 443 PACAPRTFR--VQEDAAPHTLLGSVVGTDMDYPHDNIEYYT---SGGPTTFAVDRLSGEV 497
PA + V E+ AP TL+G + D+D P I Y S F++ G +
Sbjct: 372 PAFTQAAYHLTVPENKAPGTLVGQISAADLDSPASPIRYSILPHSDPERCFSIQPEEGTI 431
Query: 498 HLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQEL 557
H PLD E + + LTVL + + + I+ D ND+AP+ P+
Sbjct: 432 HTAAPLDREARAWHNLTVLATELDSSAQ-----ASRVQVAIQTLDENDNAPQLAEPYDTF 486
Query: 558 TI-YAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPFW 616
A G+ ++V + + + +G ++ F +Q + L+L P
Sbjct: 487 VCDSAAPGQLIQVIRALDRDEVGNSSHVSFQGPLGPDA--NFTVQDNRDGSASLLL-PSR 543
Query: 617 PEQPRTYELLICVADAGPSTPHLSTTATIIV 647
P PR L+ + P LS+TAT+ V
Sbjct: 544 PAPPRHAPYLVPIELWDWGQPALSSTATVTV 574
Score = 50.8 bits (120), Expect = 5e-06
Identities = 84/357 (23%), Positives = 129/357 (36%), Gaps = 48/357 (13%)
Query: 432 LVMVTPINEFSPA--CAPRTFRVQEDAAPHTLLGSVVGTDMDYPH----DNIEYYTSGGP 485
++ V IN+ P P V E + T + V D D P + Y G
Sbjct: 137 IIKVQDINDNPPIFPLGPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGL 196
Query: 486 TTFAVDRLSGEVHLLGP-LDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVN 544
F+VD +G V P +D E Q + + + D G LSGS T+T+ + DVN
Sbjct: 197 PFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGG---LSGSTTVTVTLSDVN 253
Query: 545 DHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAI 604
D+ P+ + ++ G V ++ Q P + +YSI+ G F + +
Sbjct: 254 DNPPKFPQSLYQFSVVETAGPGTLVGRLRAQDPDLGDNALMAYSILDGEGSEAFSISTDL 313
Query: 605 LVHSDL--VLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTH 662
L V P E R+Y + T T+I RR ++
Sbjct: 314 QGRDGLLTVRKPLDFESQRSYSF------------RVEATNTLIDPAYLRRGPFKDVASV 361
Query: 663 RTTVPSTMTPMLVTDTEAFWQPQPWFVVVLTATGALLLLALGWLLGRLLQGLAQLLQAPS 722
R V P AF Q V A G L+G++ A L +P+
Sbjct: 362 RVAVQDAPEP------PAFTQAAYHLTVPENK-------APGTLVGQI---SAADLDSPA 405
Query: 723 KPAQALLLN--------SIQGTEGSIEGFLEAPKMEMSQAPSSVMSLHFDGRAQDSR 771
P + +L SIQ EG+I + + +V++ D AQ SR
Sbjct: 406 SPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDREARAWHNLTVLATELDSSAQASR 462
Score = 47.4 bits (111), Expect = 5e-05
Identities = 28/101 (27%), Positives = 47/101 (46%), Gaps = 6/101 (5%)
Query: 450 FRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSG--GPTTFAVDRLSGEVHLLGPLDYEQ 507
F ++E A P +L + +D+D +Y +G T F +D +G +H+ LD E+
Sbjct: 52 FVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEATGNIHVTKSLDREE 111
Query: 508 QRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAP 548
+ Y L +D N L I+V+D+ND+ P
Sbjct: 112 KAQYVLLAQAVDRAS----NRPLEPPSEFIIKVQDINDNPP 148
Score = 47.4 bits (111), Expect = 5e-05
Identities = 57/223 (25%), Positives = 98/223 (43%), Gaps = 18/223 (8%)
Query: 222 VIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD-----LRYEIL-SPVPS 275
V V+ P P + F + A ++T+PEN APG+ V Q+ A +D +RY IL P
Sbjct: 363 VAVQDAPEPPA---FTQAAYHLTVPENKAPGTLVGQISAADLDSPASPIRYSILPHSDPE 419
Query: 276 PLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWP 335
FSI +G + T PL+ A L V A E ++++ + + N
Sbjct: 420 RCFSIQPEEGTIHTAAPLD---REARAWHNLTVLATELDSSAQASRVQVAIQTLDENDNA 476
Query: 336 PRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLE 395
P+ L + + ++A G ++ + D D VG + F+ P + +
Sbjct: 477 PQ-LAEPYDTFVCDSAAPGQLIQVIRALDRDEVGNSSHVS--FQGPLGPDANFTVQDNRD 533
Query: 396 VNATLDCDTPGACFQHAASILVL---DGGQPQMTTEVPVLVMV 435
+A+L + A +HA ++ + D GQP +++ V V V
Sbjct: 534 GSASLLLPSRPAPPRHAPYLVPIELWDWGQPALSSTATVTVSV 576
>gi|14195605 protocadherin beta 16 precursor [Homo sapiens]
Length = 776
Score = 83.6 bits (205), Expect = 7e-16
Identities = 118/475 (24%), Positives = 191/475 (40%), Gaps = 73/475 (15%)
Query: 216 QSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD------LRYEI 269
+S V ++V+ + + F + + IPEN GS V V AR +D + Y +
Sbjct: 222 RSGTAQVRIEVVDINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDGGANGKISYTL 281
Query: 270 LSPVP--SPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMN 327
P S + G VR ++ + V ++KA + G L S K L +
Sbjct: 282 FQPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEV---RIKATDGGGL--SGKCTLLLQ 336
Query: 328 VQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSV--GATL-----DYKLWFRS 380
V VN PP+ + L S IPE +P V+ + DPDS G T+ D +
Sbjct: 337 VVDVNDNPPQVTMSALTSPIPENSPE-IVVAVFSVSDPDSGNNGKTISSIQEDLPFLLKP 395
Query: 381 SSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINE 440
S + +R L+ A + + ++ V D G P++ TE + V ++ +N+
Sbjct: 396 SVKNFYTLVTERALDREARAE---------YNITLTVTDMGTPRLKTEHNITVQISDVND 446
Query: 441 FSPACAPRTFR--VQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGP--------TTFAV 490
+P ++ V+E+ +P +GSV TD D + Y+ P + ++
Sbjct: 447 NAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSI 506
Query: 491 DRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPEC 550
+ +G + L LDYE R + V D G LS + + V D ND++P
Sbjct: 507 NADNGHLFALRSLDYEALREFEFRVSATDRGSPA-----LSSEALVRVLVLDANDNSP-- 559
Query: 551 EPPFQELTIYAPLGRSVEVTKMSCQIPQ--EPQRLIYSYSIVGGNSQNRFILQGAILVHS 608
+Y S T++ +P+ EP L+ V G+S L +L +
Sbjct: 560 ------FVLYPLQNGSAPCTEL---VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKAT 610
Query: 609 DLVLGPFWPE--QPRTYELL-----------ICVADAGPSTPHLSTTATIIVHLV 650
+ L W + RT LL + V D G P S TAT+ V LV
Sbjct: 611 EPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNG--EPPRSATATLHVLLV 663
Score = 66.6 bits (161), Expect = 8e-11
Identities = 88/364 (24%), Positives = 155/364 (42%), Gaps = 65/364 (17%)
Query: 343 LVSQIPETAPVGTVLNTLTCEDPDSVGAT--LDYKLWFRSSSNPASLCLYD-------RV 393
++ +IPE +P+GT D D VG+ +YK+ S S+ + +++
Sbjct: 138 MILKIPENSPLGTEFPLNHALDLD-VGSNNVQNYKI---SPSSHFRVLIHEFRDGRKYPE 193
Query: 394 LEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFRVQ 453
L ++ LD + Q ++ LDGG P + V + V IN+ +P ++VQ
Sbjct: 194 LVLDKELDREEEP---QLRLTLTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQPIYKVQ 250
Query: 454 --EDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPT-----TFAVDRLSGEVHLLGPLDYE 506
E++ +L+ +V D+D + YT P+ T V+ ++GEV L +D+E
Sbjct: 251 IPENSPLGSLVATVSARDLDGGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFE 310
Query: 507 QQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRS 566
Y + + D G LSG CT+ ++V DVND+ P+
Sbjct: 311 MVTSYEVRIKATDGGG-------LSGKCTLLLQVVDVNDNPPQ----------------- 346
Query: 567 VEVTKMSCQIPQ-EPQRLIYSYSIVGGNSQNR------------FILQGAILVHSDLVLG 613
V ++ ++ IP+ P+ ++ +S+ +S N F+L+ ++ LV
Sbjct: 347 VTMSALTSPIPENSPEIVVAVFSVSDPDSGNNGKTISSIQEDLPFLLKPSVKNFYTLVTE 406
Query: 614 PFWPEQPRT-YELLICVADAGPSTPHLSTTATIIVHL--VPRRASTVATSTHRTTVPSTM 670
+ R Y + + V D G TP L T I V + V A T +++ V
Sbjct: 407 RALDREARAEYNITLTVTDMG--TPRLKTEHNITVQISDVNDNAPTFTQTSYTLFVRENN 464
Query: 671 TPML 674
+P L
Sbjct: 465 SPAL 468
Score = 47.4 bits (111), Expect = 5e-05
Identities = 42/144 (29%), Positives = 65/144 (45%), Gaps = 16/144 (11%)
Query: 435 VTPINEFSPACAPRTF--RVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPTTFAV-- 490
V IN+ SP + ++ E++ T D+D +N++ Y + F V
Sbjct: 123 VIDINDHSPMFTEKEMILKIPENSPLGTEFPLNHALDLDVGSNNVQNYKISPSSHFRVLI 182
Query: 491 -----DRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVND 545
R E+ L LD E++ RLT+ +D G SG+ + IEV D+ND
Sbjct: 183 HEFRDGRKYPELVLDKELDREEEPQLRLTLTALDGGSPPR-----SGTAQVRIEVVDIND 237
Query: 546 HAPECEPPFQELTI--YAPLGRSV 567
+APE E P ++ I +PLG V
Sbjct: 238 NAPEFEQPIYKVQIPENSPLGSLV 261
Score = 44.7 bits (104), Expect = 3e-04
Identities = 77/344 (22%), Positives = 134/344 (38%), Gaps = 34/344 (9%)
Query: 224 VKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVDL------RYEILSPVPSPL 277
++V+ + F E+ + IPEN G+E A +D+ Y+I PS
Sbjct: 121 LRVIDINDHSPMFTEKEMILKIPENSPLGTEFPLNHALDLDVGSNNVQNYKIS---PSSH 177
Query: 278 FSI-------GRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQL 330
F + GR EL R + RL + A + G S + + V
Sbjct: 178 FRVLIHEFRDGRK--YPELVLDKELDREEEPQL-RLTLTALDGGSPPRSGTAQVRIEVVD 234
Query: 331 VNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPD-SVGATLDYKLWFRSSSNPASLCL 389
+N P + QIPE +P+G+++ T++ D D + Y L+ S +L +
Sbjct: 235 INDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDGGANGKISYTLFQPSEDISKTLEV 294
Query: 390 YDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSP--ACAP 447
EV D + I DGG ++ + +L+ V +N+ P +
Sbjct: 295 NPMTGEVRLRKQVDFE-MVTSYEVRIKATDGG--GLSGKCTLLLQVVDVNDNPPQVTMSA 351
Query: 448 RTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPTTFAVDRLSGEVHLL---GPLD 504
T + E+ +P ++ +D D ++ + F + + L LD
Sbjct: 352 LTSPIPEN-SPEIVVAVFSVSDPDSGNNGKTISSIQEDLPFLLKPSVKNFYTLVTERALD 410
Query: 505 YEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAP 548
E + Y +T+ V D G + H IT+++ DVND+AP
Sbjct: 411 REARAEYNITLTVTDMGTPRLKTEH-----NITVQISDVNDNAP 449
>gi|14277677 protocadherin gamma subfamily C, 3 isoform 2 precursor
[Homo sapiens]
Length = 863
Score = 83.2 bits (204), Expect = 9e-16
Identities = 132/527 (25%), Positives = 214/527 (40%), Gaps = 75/527 (14%)
Query: 224 VKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVDL--RYEILSPVPS------ 275
+KVL + F + + E+ G+ VVQV A +D EI+ S
Sbjct: 232 IKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQVLATDLDEGPNGEIIYSFGSHNRAGV 291
Query: 276 -PLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLW 334
LF++ G++ L+ T + + ++A ++G A + + V VN
Sbjct: 292 RQLFALDLVTGMLTIKGRLDF---EDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDN 348
Query: 335 PPRCLPALLVSQIPETAPVGTVLNTLTCEDPDS-----VGATLDYKLWFRSSSNPASLCL 389
P + S +PE AP+GTV+ L+ D D+ V + L F +S SL
Sbjct: 349 APEITVTSVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTS---SLKN 405
Query: 390 YDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRT 449
Y L+ +A LD +T ++ SI D G P ++ V V V+ IN+ P + +
Sbjct: 406 Y-FTLKTSADLDRETVP---EYNLSITARDAGTPSLSALTIVRVQVSDINDNPPQSSQSS 461
Query: 450 FRV--QEDAAPHTLLGSVVGTDMDYPHD-NIEYY--TSGGPT-----TFAVDRLSGEVHL 499
+ V +E+ P + ++ D D P + + ++ G T F ++R +G V
Sbjct: 462 YDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSS 521
Query: 500 LGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTI 559
L PLDYE +R + LT + D G L+ + ++ I V D ND+AP+ P
Sbjct: 522 LVPLDYEDRREFELTAHISDGGTPV-----LATNISVNIFVTDRNDNAPQVLYP------ 570
Query: 560 YAPLGRSVEVTKMSCQIPQEPQRLI-----------YSYSIVGGNSQNRFILQGAILVHS 608
P G SVE+ R++ SYS++G +Q+ F AI +H+
Sbjct: 571 -RPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSLLGSPNQSLF----AIGLHT 625
Query: 609 DLV--LGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTHRTTV 666
+ P L + + D G P LSTTAT+ V + T + R
Sbjct: 626 GQISTARPVQDTDSPRQTLTVLIKDNG--EPSLSTTATLTVSV------TEDSPEARAEF 677
Query: 667 PSTMTPMLVTDTEAFWQPQPWFVV----VLTATGALLLLALGWLLGR 709
PS P F+ +V V+T G ++ W R
Sbjct: 678 PSGSAPREQKKNLTFYLLLSLILVSVGFVVTVFGVIIFKVYKWKQSR 724
Score = 72.4 bits (176), Expect = 2e-12
Identities = 111/443 (25%), Positives = 182/443 (41%), Gaps = 70/443 (15%)
Query: 245 IPENLAPGSEVVQVQAR-GVDL------RYEILSPVPSPLFSIGRADGVVRTTTPLELAR 297
IPE G V V A G+DL R+ ++S F + R G + L+
Sbjct: 37 IPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGEMFVNDRLDREE 96
Query: 298 TSGTAVS---RLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVG 354
GT S L++ +L++ + + +Q +N P + +I E G
Sbjct: 97 LCGTLPSCTVTLELVVENPLELFS-----VEVVIQDINDNNPAFPTQEMKLEISEAVAPG 151
Query: 355 TVLNTLTCEDPDSVGATLD-YKLW------FRSSSNPASLCLYDRVLEVNATLDCDTPGA 407
T + DPD +L Y+L R + S + VLE LD + +
Sbjct: 152 TRFPLESAHDPDVGSNSLQTYELSRNEYFALRVQTREDSTKYAELVLE--RALDREREPS 209
Query: 408 CFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTF--RVQEDAAPHTLLGSV 465
+ LDGG P ++ +P+ + V N+ +P + RV EDA T + V
Sbjct: 210 L---QLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQV 266
Query: 466 VGTDMDY-PHDNIEY-----YTSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVID 519
+ TD+D P+ I Y +G FA+D ++G + + G LD+E +L+ + + D
Sbjct: 267 LATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKD 326
Query: 520 HGQDQNPNHHLSGSCTITIEVEDVNDHAPE--CEPPFQELTIYAPLGRSVEVTK------ 571
G + H C + +EV DVND+APE + + APLG + +
Sbjct: 327 KGANPEGAH-----CKVLVEVVDVNDNAPEITVTSVYSPVPEDAPLGTVIALLSVTDLDA 381
Query: 572 -----MSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPRTYELL 626
++C++ P L +S + + +N F L+ + + + V PE Y L
Sbjct: 382 GENGLVTCEV---PPGLPFSLT---SSLKNYFTLKTSADLDRETV-----PE----YNLS 426
Query: 627 ICVADAGPSTPHLSTTATIIVHL 649
I DAG TP LS + V +
Sbjct: 427 ITARDAG--TPSLSALTIVRVQV 447
>gi|14277675 protocadherin gamma subfamily C, 3 isoform 1 precursor
[Homo sapiens]
Length = 934
Score = 83.2 bits (204), Expect = 9e-16
Identities = 132/527 (25%), Positives = 214/527 (40%), Gaps = 75/527 (14%)
Query: 224 VKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVDL--RYEILSPVPS------ 275
+KVL + F + + E+ G+ VVQV A +D EI+ S
Sbjct: 232 IKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQVLATDLDEGPNGEIIYSFGSHNRAGV 291
Query: 276 -PLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLW 334
LF++ G++ L+ T + + ++A ++G A + + V VN
Sbjct: 292 RQLFALDLVTGMLTIKGRLDF---EDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDN 348
Query: 335 PPRCLPALLVSQIPETAPVGTVLNTLTCEDPDS-----VGATLDYKLWFRSSSNPASLCL 389
P + S +PE AP+GTV+ L+ D D+ V + L F +S SL
Sbjct: 349 APEITVTSVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTS---SLKN 405
Query: 390 YDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRT 449
Y L+ +A LD +T ++ SI D G P ++ V V V+ IN+ P + +
Sbjct: 406 Y-FTLKTSADLDRETVP---EYNLSITARDAGTPSLSALTIVRVQVSDINDNPPQSSQSS 461
Query: 450 FRV--QEDAAPHTLLGSVVGTDMDYPHD-NIEYY--TSGGPT-----TFAVDRLSGEVHL 499
+ V +E+ P + ++ D D P + + ++ G T F ++R +G V
Sbjct: 462 YDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSS 521
Query: 500 LGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTI 559
L PLDYE +R + LT + D G L+ + ++ I V D ND+AP+ P
Sbjct: 522 LVPLDYEDRREFELTAHISDGGTPV-----LATNISVNIFVTDRNDNAPQVLYP------ 570
Query: 560 YAPLGRSVEVTKMSCQIPQEPQRLI-----------YSYSIVGGNSQNRFILQGAILVHS 608
P G SVE+ R++ SYS++G +Q+ F AI +H+
Sbjct: 571 -RPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSLLGSPNQSLF----AIGLHT 625
Query: 609 DLV--LGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTHRTTV 666
+ P L + + D G P LSTTAT+ V + T + R
Sbjct: 626 GQISTARPVQDTDSPRQTLTVLIKDNG--EPSLSTTATLTVSV------TEDSPEARAEF 677
Query: 667 PSTMTPMLVTDTEAFWQPQPWFVV----VLTATGALLLLALGWLLGR 709
PS P F+ +V V+T G ++ W R
Sbjct: 678 PSGSAPREQKKNLTFYLLLSLILVSVGFVVTVFGVIIFKVYKWKQSR 724
Score = 72.4 bits (176), Expect = 2e-12
Identities = 111/443 (25%), Positives = 182/443 (41%), Gaps = 70/443 (15%)
Query: 245 IPENLAPGSEVVQVQAR-GVDL------RYEILSPVPSPLFSIGRADGVVRTTTPLELAR 297
IPE G V V A G+DL R+ ++S F + R G + L+
Sbjct: 37 IPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGEMFVNDRLDREE 96
Query: 298 TSGTAVS---RLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVG 354
GT S L++ +L++ + + +Q +N P + +I E G
Sbjct: 97 LCGTLPSCTVTLELVVENPLELFS-----VEVVIQDINDNNPAFPTQEMKLEISEAVAPG 151
Query: 355 TVLNTLTCEDPDSVGATLD-YKLW------FRSSSNPASLCLYDRVLEVNATLDCDTPGA 407
T + DPD +L Y+L R + S + VLE LD + +
Sbjct: 152 TRFPLESAHDPDVGSNSLQTYELSRNEYFALRVQTREDSTKYAELVLE--RALDREREPS 209
Query: 408 CFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTF--RVQEDAAPHTLLGSV 465
+ LDGG P ++ +P+ + V N+ +P + RV EDA T + V
Sbjct: 210 L---QLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQV 266
Query: 466 VGTDMDY-PHDNIEY-----YTSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVID 519
+ TD+D P+ I Y +G FA+D ++G + + G LD+E +L+ + + D
Sbjct: 267 LATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKD 326
Query: 520 HGQDQNPNHHLSGSCTITIEVEDVNDHAPE--CEPPFQELTIYAPLGRSVEVTK------ 571
G + H C + +EV DVND+APE + + APLG + +
Sbjct: 327 KGANPEGAH-----CKVLVEVVDVNDNAPEITVTSVYSPVPEDAPLGTVIALLSVTDLDA 381
Query: 572 -----MSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPRTYELL 626
++C++ P L +S + + +N F L+ + + + V PE Y L
Sbjct: 382 GENGLVTCEV---PPGLPFSLT---SSLKNYFTLKTSADLDRETV-----PE----YNLS 426
Query: 627 ICVADAGPSTPHLSTTATIIVHL 649
I DAG TP LS + V +
Sbjct: 427 ITARDAG--TPSLSALTIVRVQV 447
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 82.8 bits (203), Expect = 1e-15
Identities = 120/491 (24%), Positives = 197/491 (40%), Gaps = 47/491 (9%)
Query: 180 PFSI-NEQGWLQAPSQGLLGQAQKVFQLQISVSFGQR-QSCQGMVIVKVLPVPSSQVSFL 237
PF I N GW+ ++ + + +V G S V + VL V + F
Sbjct: 629 PFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFT 688
Query: 238 EQAQNITIPENLAPGSEVVQVQARGVD----LRYEILSPVPSPLFSIG--RADGVVRTTT 291
+ + + E+ A GS V+ +QAR D + Y++ F++ R G++
Sbjct: 689 QPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLAL 748
Query: 292 PLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETA 351
PL+ + + V A S ++ +NV N P + + E
Sbjct: 749 PLDYKQ------EQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDR 802
Query: 352 PVGTVLNTLTCEDPDS-VGATLDYKLW-----FRSSSNPASLCLYDRVLEVNATLDCDTP 405
PVGT + TL+ D D+ A + Y + FR +P S +Y + LD +
Sbjct: 803 PVGTSIATLSANDEDTGENARITYVIQDPVPQFRI--DPDSGTMYTMM-----ELDYENQ 855
Query: 406 GACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFR--VQEDAAPHTLLG 463
A + +I+ D G PQ + + +++ N+ +P ++ + EDA P T +
Sbjct: 856 VA---YTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSIL 912
Query: 464 SVVGTDMDY-PHDNIEYYTSGGPT---TFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVID 519
V TD D P+ + Y GG F ++ SG + LD E +Y L L +D
Sbjct: 913 QVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVD 972
Query: 520 HGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQE 579
G LS S I + + D+ND+AP E EL + V K+ P E
Sbjct: 973 RGSPTP----LSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDE 1028
Query: 580 PQRLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHL 639
Y IV G+ ++ F L L++ DL + R +L+ A + P L
Sbjct: 1029 GPNAQIMYQIVEGDMRHFFQLD---LLNGDLRAMVELDFEVRREYVLVVQATSAP----L 1081
Query: 640 STTATIIVHLV 650
+ AT+ + LV
Sbjct: 1082 VSRATVHILLV 1092
Score = 76.6 bits (187), Expect = 8e-14
Identities = 117/479 (24%), Positives = 187/479 (39%), Gaps = 50/479 (10%)
Query: 204 FQLQISVSFGQRQ---SCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQA 260
+ L I G R + G+V V+VL V ++ F+ T+ EN+ G VV +QA
Sbjct: 530 YSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQA 589
Query: 261 RGVD------LRYEIL---------------SPVPSPLFSIGRADGVVRTTTPLELARTS 299
D L Y ++ +P P+P F + T EL R
Sbjct: 590 VDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREE 649
Query: 300 GTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNT 359
S V+A + G S+ ++++ V VN P ++ E A VG+ + T
Sbjct: 650 VEHYS-FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLT 708
Query: 360 LTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLD 419
L D D+ + + Y+L ++ N +L + L D Q +L +
Sbjct: 709 LQARDRDA-NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK----QEQQYVLAVT 763
Query: 420 GGQPQMTTEVPVLVMVTPINEFSPA--CAPRTFRVQEDAAPHTLLGSVVGTDMDYPHD-N 476
+ VL+ VT N P + T V ED T + ++ D D +
Sbjct: 764 ASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENAR 823
Query: 477 IEYYTSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTI 536
I Y F +D SG ++ + LDYE Q Y LT++ D+G Q S + T+
Sbjct: 824 ITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQK-----SDTTTL 878
Query: 537 TIEVEDVNDHAPECEPPFQELTIY--APLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNS 594
I + D ND+AP+ F + +I+ AP S+ + + RL+Y++ G +
Sbjct: 879 EILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQ-GGDDG 937
Query: 595 QNRFILQ---GAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLV 650
F ++ G I L E Y L D G TP LS + I V ++
Sbjct: 938 DGDFYIEPTSGVIRTQRRLD-----RENVAVYNLWALAVDRGSPTP-LSASVEIQVTIL 990
Score = 70.9 bits (172), Expect = 4e-12
Identities = 62/244 (25%), Positives = 106/244 (43%), Gaps = 10/244 (4%)
Query: 411 HAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFR--VQEDAAPHTLLGSVVGT 468
H + +D P + + V+V N+ SP +R V+E+ + ++ +
Sbjct: 319 HVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRAS 378
Query: 469 DMDYP-HDNIEYYTSGGP-TTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNP 526
D D P + N+ Y GG F ++ SG V LD E+ Y+L V D G++ P
Sbjct: 379 DRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGP 438
Query: 527 NHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYS 586
LS + T+ IEVED ND+ P+ + + +G + V ++ + Q
Sbjct: 439 ---LSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIH 495
Query: 587 YSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATII 646
YSI+ GN +F L + V+ P E + Y L I D G P ++++ +
Sbjct: 496 YSILSGNVAGQFYLHSLSGILD--VINPLDFEDVQKYSLSIKAQDGG-RPPLINSSGVVS 552
Query: 647 VHLV 650
V ++
Sbjct: 553 VQVL 556
Score = 67.0 bits (162), Expect = 6e-11
Identities = 102/443 (23%), Positives = 182/443 (41%), Gaps = 54/443 (12%)
Query: 181 FSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQ----SCQGMVIVKVLPVPSSQVSF 236
F +NE + + L + +QL + + R S V ++V + F
Sbjct: 400 FQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQF 459
Query: 237 LEQAQNITIPENLAPGSEVVQVQARGVD------LRYEILSPVPSPLFSIGRADGVVRTT 290
EQ + +PE++ + V++VQA D + Y ILS + F + G++
Sbjct: 460 SEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVI 519
Query: 291 TPLELARTSGTAVSRLQVKAFEQGQ--LWASAKLNLTMNVQLVNLWPPRCLPALLVSQIP 348
PL+ ++S +KA + G+ L S+ + +++ V VN P + + + +
Sbjct: 520 NPLDFEDVQKYSLS---IKAQDGGRPPLINSSGV-VSVQVLDVNDNEPIFVSSPFQATVL 575
Query: 349 ETAPVGTVLNTLTCEDPDS-VGATLDYKLWFRSSS----------NPA-------SLCLY 390
E P+G + + D DS A L Y+L +S+ NPA +
Sbjct: 576 ENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNS 635
Query: 391 DRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTF 450
+ V A LD + ++ + +D G P M++ V + V +N+ P T+
Sbjct: 636 SGWITVCAELDRE---EVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTY 692
Query: 451 --RVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPT----TFAVDRLSGEVHLLGPLD 504
R+ EDAA + + ++ D D + I Y +GG T + R G + L PLD
Sbjct: 693 ELRLNEDAAVGSSVLTLQARDRD-ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLD 751
Query: 505 YEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIY--AP 562
Y+Q++ Y L V D + S + + I V D N H P + +++ P
Sbjct: 752 YKQEQQYVLAVTASDGTR--------SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRP 803
Query: 563 LGRSVEVTKMSCQIPQEPQRLIY 585
+G S+ + + E R+ Y
Sbjct: 804 VGTSIATLSANDEDTGENARITY 826
>gi|14196471 protocadherin gamma subfamily A, 5 isoform 2 precursor
[Homo sapiens]
Length = 813
Score = 82.4 bits (202), Expect = 1e-15
Identities = 111/474 (23%), Positives = 187/474 (39%), Gaps = 40/474 (8%)
Query: 222 VIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVDL------RYEILSPVPS 275
V V+++ + + F ++ + + EN A G+ +V AR D+ Y++ S +
Sbjct: 119 VEVEIIDINDNFPRFRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLHF 178
Query: 276 PLFSIGRADGVVRTTTPLE--LARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNL 333
L + DG LE L R T V L + A + G S ++ + V N
Sbjct: 179 SLDVVSGTDGQKYPELVLEQPLDREKET-VHDLLLTALDGGDPVLSGTTHIRVTVLDAND 237
Query: 334 WPPRCLPALLVSQIPETAPVGTVLNTLTCEDPD-SVGATLDYKLWFRSSSNPASLCLYDR 392
P P+ +PE PVGT L LT DPD + L Y + L
Sbjct: 238 NAPLFTPSEYSVSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSN 297
Query: 393 VLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSP--ACAPRTF 450
+ E++ D + F + ++ DGG + V+V V +N+ +P T
Sbjct: 298 LGEISTLQSLDYEESRF-YLMEVVAQDGG--ALVASAKVVVTVQDVNDNAPEVILTSLTS 354
Query: 451 RVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPTTFAVDR-LSGEVHLL--GPLDYEQ 507
+ ED P T++ D D + + F +++ + HLL LD E+
Sbjct: 355 SISEDCLPGTVIALFSVHDGDSGENGEIACSIPRNLPFKLEKSVDNYYHLLTTRDLDREE 414
Query: 508 QRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSV 567
Y +T+ V+DHG LS I ++V DVND+ P ++ R V
Sbjct: 415 TSDYNITLTVMDHGTPP-----LSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGV 469
Query: 568 EVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSD----LVLGPFWPEQPRTY 623
+ ++ P +YS+ Q L + ++SD L F EQ R
Sbjct: 470 SIFSVTAHDPDSGDNARVTYSLAEDTFQGA-PLSSYVSINSDTGVLYALRSFDYEQLRDL 528
Query: 624 ELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTHRTTVPSTMTPMLVTD 677
+L + +D+G P LS+ ++ + ++ + +T P + P L TD
Sbjct: 529 QLWVTASDSG--NPPLSSNVSLSLFVLDQNDNT----------PEILYPALPTD 570
Score = 50.4 bits (119), Expect = 6e-06
Identities = 95/441 (21%), Positives = 163/441 (36%), Gaps = 48/441 (10%)
Query: 133 SPAGEMIQVPETVTPGARLYTLLL--PGLELHGAQMSIISAQDLPHFPGPFSINEQGWLQ 190
+P+ + VPE + G RL L P ++G +++ + F ++
Sbjct: 243 TPSEYSVSVPENIPVGTRLLMLTATDPDEGING-KLTYSFRNEEEKISETFQLDSNLGEI 301
Query: 191 APSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLA 250
+ Q L + + + +++ G V+V V V + + + +I E+
Sbjct: 302 STLQSLDYEESRFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCL 361
Query: 251 PGSEVVQVQARGVDL--RYEILSPVPSPL-FSIGRA-DGVVRTTTPLELARTSGTAVSRL 306
PG+ + D EI +P L F + ++ D T +L R T+ +
Sbjct: 362 PGTVIALFSVHDGDSGENGEIACSIPRNLPFKLEKSVDNYYHLLTTRDLDREE-TSDYNI 420
Query: 307 QVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPD 366
+ + G S + ++ + V VN PP A + + E P G + ++T DPD
Sbjct: 421 TLTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPD 480
Query: 367 SV-GATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAAS------ILVLD 419
S A + Y L + A L Y + +N+ F + + D
Sbjct: 481 SGDNARVTYSL-AEDTFQGAPLSSY---VSINSDTGVLYALRSFDYEQLRDLQLWVTASD 536
Query: 420 GGQPQMTTEVPVLVMVTPINEFSPAC---------------APRTFRVQEDAAPHTLLGS 464
G P +++ V + + V N+ +P APR+ A P L+
Sbjct: 537 SGNPPLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVELAPRS------AEPGYLVTK 590
Query: 465 VVGTDMDYPHD---NIEYYTSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHG 521
VV D D + + + P FAV +GEV L L V V DHG
Sbjct: 591 VVAVDKDSGQNAWLSYRLLKASEPGLFAVGLHTGEVRTARALLDRDALKQSLVVAVEDHG 650
Query: 522 QDQNPNHHLSGSCTITIEVED 542
Q LS + T+T+ V D
Sbjct: 651 QPP-----LSATFTVTVAVAD 666
>gi|11056024 protocadherin gamma subfamily A, 5 isoform 1 precursor
[Homo sapiens]
Length = 931
Score = 82.4 bits (202), Expect = 1e-15
Identities = 111/474 (23%), Positives = 187/474 (39%), Gaps = 40/474 (8%)
Query: 222 VIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVDL------RYEILSPVPS 275
V V+++ + + F ++ + + EN A G+ +V AR D+ Y++ S +
Sbjct: 119 VEVEIIDINDNFPRFRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLHF 178
Query: 276 PLFSIGRADGVVRTTTPLE--LARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNL 333
L + DG LE L R T V L + A + G S ++ + V N
Sbjct: 179 SLDVVSGTDGQKYPELVLEQPLDREKET-VHDLLLTALDGGDPVLSGTTHIRVTVLDAND 237
Query: 334 WPPRCLPALLVSQIPETAPVGTVLNTLTCEDPD-SVGATLDYKLWFRSSSNPASLCLYDR 392
P P+ +PE PVGT L LT DPD + L Y + L
Sbjct: 238 NAPLFTPSEYSVSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSN 297
Query: 393 VLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSP--ACAPRTF 450
+ E++ D + F + ++ DGG + V+V V +N+ +P T
Sbjct: 298 LGEISTLQSLDYEESRF-YLMEVVAQDGG--ALVASAKVVVTVQDVNDNAPEVILTSLTS 354
Query: 451 RVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPTTFAVDR-LSGEVHLL--GPLDYEQ 507
+ ED P T++ D D + + F +++ + HLL LD E+
Sbjct: 355 SISEDCLPGTVIALFSVHDGDSGENGEIACSIPRNLPFKLEKSVDNYYHLLTTRDLDREE 414
Query: 508 QRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSV 567
Y +T+ V+DHG LS I ++V DVND+ P ++ R V
Sbjct: 415 TSDYNITLTVMDHGTPP-----LSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGV 469
Query: 568 EVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSD----LVLGPFWPEQPRTY 623
+ ++ P +YS+ Q L + ++SD L F EQ R
Sbjct: 470 SIFSVTAHDPDSGDNARVTYSLAEDTFQGA-PLSSYVSINSDTGVLYALRSFDYEQLRDL 528
Query: 624 ELLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTHRTTVPSTMTPMLVTD 677
+L + +D+G P LS+ ++ + ++ + +T P + P L TD
Sbjct: 529 QLWVTASDSG--NPPLSSNVSLSLFVLDQNDNT----------PEILYPALPTD 570
Score = 50.4 bits (119), Expect = 6e-06
Identities = 95/441 (21%), Positives = 163/441 (36%), Gaps = 48/441 (10%)
Query: 133 SPAGEMIQVPETVTPGARLYTLLL--PGLELHGAQMSIISAQDLPHFPGPFSINEQGWLQ 190
+P+ + VPE + G RL L P ++G +++ + F ++
Sbjct: 243 TPSEYSVSVPENIPVGTRLLMLTATDPDEGING-KLTYSFRNEEEKISETFQLDSNLGEI 301
Query: 191 APSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLA 250
+ Q L + + + +++ G V+V V V + + + +I E+
Sbjct: 302 STLQSLDYEESRFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCL 361
Query: 251 PGSEVVQVQARGVDL--RYEILSPVPSPL-FSIGRA-DGVVRTTTPLELARTSGTAVSRL 306
PG+ + D EI +P L F + ++ D T +L R T+ +
Sbjct: 362 PGTVIALFSVHDGDSGENGEIACSIPRNLPFKLEKSVDNYYHLLTTRDLDREE-TSDYNI 420
Query: 307 QVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPD 366
+ + G S + ++ + V VN PP A + + E P G + ++T DPD
Sbjct: 421 TLTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPD 480
Query: 367 SV-GATLDYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAAS------ILVLD 419
S A + Y L + A L Y + +N+ F + + D
Sbjct: 481 SGDNARVTYSL-AEDTFQGAPLSSY---VSINSDTGVLYALRSFDYEQLRDLQLWVTASD 536
Query: 420 GGQPQMTTEVPVLVMVTPINEFSPAC---------------APRTFRVQEDAAPHTLLGS 464
G P +++ V + + V N+ +P APR+ A P L+
Sbjct: 537 SGNPPLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVELAPRS------AEPGYLVTK 590
Query: 465 VVGTDMDYPHD---NIEYYTSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHG 521
VV D D + + + P FAV +GEV L L V V DHG
Sbjct: 591 VVAVDKDSGQNAWLSYRLLKASEPGLFAVGLHTGEVRTARALLDRDALKQSLVVAVEDHG 650
Query: 522 QDQNPNHHLSGSCTITIEVED 542
Q LS + T+T+ V D
Sbjct: 651 QPP-----LSATFTVTVAVAD 666
>gi|14717401 protocadherin alpha subfamily C, 1 isoform 1 precursor
[Homo sapiens]
Length = 963
Score = 81.6 bits (200), Expect = 3e-15
Identities = 126/435 (28%), Positives = 174/435 (40%), Gaps = 46/435 (10%)
Query: 245 IPENLAPGSEVVQVQARGVD------LRYEILSPVPSPLFSIG-RADGVVRTTTPLELAR 297
IPE L PG+ A+ D L Y LSP +G R DG LE A
Sbjct: 133 IPEFLTPGARFTLPNAQDDDEGSNGILSYS-LSPSQHFRLDMGSRVDGSEYPELVLEKAL 191
Query: 298 TSGTAVSRLQVKAFEQGQLWA-SAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTV 356
+ L V G L A S +T+ V N P ++ +++PETAP GTV
Sbjct: 192 DREQRATHLLVLTARDGGLPARSGDAQVTIIVVDTNDNAPVFERSVYRTKVPETAPNGTV 251
Query: 357 LNTLTCEDPDS-VGATLDYKLWFRSSSNPASLC----LYDRVLEVNATLDCDTPGACFQH 411
L + DPD + Y L S+S A L ++ + EV P +
Sbjct: 252 LFRVQALDPDEGSNGEVQYSL---SNSTQAELRHRFHVHPKSGEVQVAASLGPPETLLE- 307
Query: 412 AASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFR--VQEDAAPHTLLG--SVVG 467
A I D G + + +LV VT +N+ +P T V EDAAP T++ SV
Sbjct: 308 -AYIEARDEGVFGLASTAKLLVEVTDVNDHAPELDFLTLSNPVPEDAAPGTVIALFSVKD 366
Query: 468 TDMDYPHDNIEYYTSGGPTTFAVDRLSGEVHLL--GPLDYEQQRLYRLTVLVIDHGQDQN 525
D+D I +S GP LL GPLD EQ Y++ + D G
Sbjct: 367 EDLDSNGRVICGMSSAGPFQLTAS-FDNYYSLLIDGPLDREQISEYQVLITASDSGSPP- 424
Query: 526 PNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIY 585
LS TIT+ V DVND+ P P QEL + G + ++ Q P + +
Sbjct: 425 ----LSTRRTITVSVADVNDNTPNFPQPQQELFVAENNGPGASLGRVFAQDPDLGKNGLV 480
Query: 586 SYSIVG----GNSQNRFIL----QGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTP 637
SY ++ G S + + GAI + F EQ R + + D G P
Sbjct: 481 SYELLDVISEGPSASSLLAVESSSGAITAKTS-----FDFEQLRGFHFQVEGRDGG--IP 533
Query: 638 HLSTTATIIVHLVPR 652
S T TI + +V R
Sbjct: 534 PRSATVTINLFVVDR 548
Score = 37.0 bits (84), Expect = 0.071
Identities = 57/199 (28%), Positives = 75/199 (37%), Gaps = 12/199 (6%)
Query: 476 NIEYYTSGGPTTFAVDRLSGEVHLLGPLDYEQQ-RLYRLTVLVIDHGQDQNPNHHLSGSC 534
N + +S F VD SG + + P D EQ R VL D + H
Sbjct: 54 NFRFLSSHRELYFGVDLPSGNLVVREPADREQLCRAKAACVLTYDLVLEDPLELH----- 108
Query: 535 TITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNS 594
I I V D ND++P +L I L T + Q E I SYS+ S
Sbjct: 109 KIRIHVLDTNDNSPLFPAGDVQLHIPEFLTPGARFTLPNAQDDDEGSNGILSYSL--SPS 166
Query: 595 QNRFILQGAILVHSD---LVLGPFWPEQPRTYELLICVA-DAGPSTPHLSTTATIIVHLV 650
Q+ + G+ + S+ LVL + R LL+ A D G TIIV
Sbjct: 167 QHFRLDMGSRVDGSEYPELVLEKALDREQRATHLLVLTARDGGLPARSGDAQVTIIVVDT 226
Query: 651 PRRASTVATSTHRTTVPST 669
A S +RT VP T
Sbjct: 227 NDNAPVFERSVYRTKVPET 245
>gi|14717403 protocadherin alpha subfamily C, 1 isoform 2 precursor
[Homo sapiens]
Length = 818
Score = 81.6 bits (200), Expect = 3e-15
Identities = 126/435 (28%), Positives = 174/435 (40%), Gaps = 46/435 (10%)
Query: 245 IPENLAPGSEVVQVQARGVD------LRYEILSPVPSPLFSIG-RADGVVRTTTPLELAR 297
IPE L PG+ A+ D L Y LSP +G R DG LE A
Sbjct: 133 IPEFLTPGARFTLPNAQDDDEGSNGILSYS-LSPSQHFRLDMGSRVDGSEYPELVLEKAL 191
Query: 298 TSGTAVSRLQVKAFEQGQLWA-SAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTV 356
+ L V G L A S +T+ V N P ++ +++PETAP GTV
Sbjct: 192 DREQRATHLLVLTARDGGLPARSGDAQVTIIVVDTNDNAPVFERSVYRTKVPETAPNGTV 251
Query: 357 LNTLTCEDPDS-VGATLDYKLWFRSSSNPASLC----LYDRVLEVNATLDCDTPGACFQH 411
L + DPD + Y L S+S A L ++ + EV P +
Sbjct: 252 LFRVQALDPDEGSNGEVQYSL---SNSTQAELRHRFHVHPKSGEVQVAASLGPPETLLE- 307
Query: 412 AASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFR--VQEDAAPHTLLG--SVVG 467
A I D G + + +LV VT +N+ +P T V EDAAP T++ SV
Sbjct: 308 -AYIEARDEGVFGLASTAKLLVEVTDVNDHAPELDFLTLSNPVPEDAAPGTVIALFSVKD 366
Query: 468 TDMDYPHDNIEYYTSGGPTTFAVDRLSGEVHLL--GPLDYEQQRLYRLTVLVIDHGQDQN 525
D+D I +S GP LL GPLD EQ Y++ + D G
Sbjct: 367 EDLDSNGRVICGMSSAGPFQLTAS-FDNYYSLLIDGPLDREQISEYQVLITASDSGSPP- 424
Query: 526 PNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIY 585
LS TIT+ V DVND+ P P QEL + G + ++ Q P + +
Sbjct: 425 ----LSTRRTITVSVADVNDNTPNFPQPQQELFVAENNGPGASLGRVFAQDPDLGKNGLV 480
Query: 586 SYSIVG----GNSQNRFIL----QGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTP 637
SY ++ G S + + GAI + F EQ R + + D G P
Sbjct: 481 SYELLDVISEGPSASSLLAVESSSGAITAKTS-----FDFEQLRGFHFQVEGRDGG--IP 533
Query: 638 HLSTTATIIVHLVPR 652
S T TI + +V R
Sbjct: 534 PRSATVTINLFVVDR 548
Score = 37.0 bits (84), Expect = 0.071
Identities = 57/199 (28%), Positives = 75/199 (37%), Gaps = 12/199 (6%)
Query: 476 NIEYYTSGGPTTFAVDRLSGEVHLLGPLDYEQQ-RLYRLTVLVIDHGQDQNPNHHLSGSC 534
N + +S F VD SG + + P D EQ R VL D + H
Sbjct: 54 NFRFLSSHRELYFGVDLPSGNLVVREPADREQLCRAKAACVLTYDLVLEDPLELH----- 108
Query: 535 TITIEVEDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNS 594
I I V D ND++P +L I L T + Q E I SYS+ S
Sbjct: 109 KIRIHVLDTNDNSPLFPAGDVQLHIPEFLTPGARFTLPNAQDDDEGSNGILSYSL--SPS 166
Query: 595 QNRFILQGAILVHSD---LVLGPFWPEQPRTYELLICVA-DAGPSTPHLSTTATIIVHLV 650
Q+ + G+ + S+ LVL + R LL+ A D G TIIV
Sbjct: 167 QHFRLDMGSRVDGSEYPELVLEKALDREQRATHLLVLTARDGGLPARSGDAQVTIIVVDT 226
Query: 651 PRRASTVATSTHRTTVPST 669
A S +RT VP T
Sbjct: 227 NDNAPVFERSVYRTKVPET 245
>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
Length = 801
Score = 80.5 bits (197), Expect = 6e-15
Identities = 113/468 (24%), Positives = 192/468 (41%), Gaps = 46/468 (9%)
Query: 213 GQRQSCQGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD-------- 264
G+ + I+K+ + ++ FL+ T+PE G+ V+QV A D
Sbjct: 142 GRPMEPESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSA 201
Query: 265 -LRYEILSPVPSPLFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLN 323
+ Y IL P FS+ GV+RT L + ++A + G
Sbjct: 202 RVVYSILQ--GQPYFSVDSKTGVIRTA--LMNMDREAKEYYEVIIQAKDMGGQLGGLAGT 257
Query: 324 LTMNVQL--VNLWPPRCLPALLVSQIPETAPVGTVLNTLTCEDPD-SVGATLDYKLWFRS 380
T+N+ L VN PPR + E+AP+ + + + +D D + A + Y +
Sbjct: 258 TTVNITLSDVNDNPPRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGD 317
Query: 381 SSNPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTE----------VP 430
++ + D +V + P + + L ++G P +
Sbjct: 318 GADAFDIST-DPNFQV-GIITVKKPLSFESKKSYTLKVEGANPHLEMRFLNLGPFQDTTT 375
Query: 431 VLVMVTPINEFSPACAPRTF--RVQEDAAPHTLLGSVVGTDMDYPHDNIEY---YTSGGP 485
V + V ++E P P + V ED A T + + D D +++I Y +S
Sbjct: 376 VHISVEDVDE-PPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSIDRSSDPG 434
Query: 486 TTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVND 545
F VD +G + PLD E+ + +TVL ++ NP+ GS +TI+V DVND
Sbjct: 435 RFFYVDITTGALMTARPLDREEFSWHNITVLAMEM---NNPSQ--VGSVPVTIKVLDVND 489
Query: 546 HAPECEPPFQELTI--YAPLGRSVE-VTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQG 602
+APE P F E + A G+ ++ V+ + P+ Q YS + N+ N I
Sbjct: 490 NAPEF-PRFYEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDN 548
Query: 603 AILVHSDLV-LGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHL 649
L F ++ + L I +AD+G P LS+T T+ + +
Sbjct: 549 QDNTARILTRRSGFRQQEQSVFHLPILIADSG--QPVLSSTGTLTIQV 594
Score = 64.7 bits (156), Expect = 3e-10
Identities = 61/253 (24%), Positives = 102/253 (40%), Gaps = 23/253 (9%)
Query: 335 PPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDRVL 394
PP P ++PE +GT + ++ +DPD ++ Y + SS+P D
Sbjct: 386 PPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSI--DRSSDPGRFFYVDITT 443
Query: 395 EVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTFR--V 452
T H ++L ++ P VPV + V +N+ +P PR + V
Sbjct: 444 GALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPE-FPRFYEAFV 502
Query: 453 QEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGP-----TTFAV-DRLSGEVHLL---GPL 503
E+A L+ +V D D P + +Y S P F + D +L
Sbjct: 503 CENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDNTARILTRRSGF 562
Query: 504 DYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVND--HAPECEPPFQELTIYA 561
++Q ++ L +L+ D GQ LS + T+TI+V +D H C P L +
Sbjct: 563 RQQEQSVFHLPILIADSGQPV-----LSSTGTLTIQVCSCDDDGHVMSCSPEAYMLPV-- 615
Query: 562 PLGRSVEVTKMSC 574
L R + ++C
Sbjct: 616 SLSRGALIAILAC 628
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,629,698
Number of Sequences: 37866
Number of extensions: 1587553
Number of successful extensions: 5970
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 120
Number of HSP's successfully gapped in prelim test: 81
Number of HSP's that attempted gapping in prelim test: 3639
Number of HSP's gapped (non-prelim): 933
length of query: 788
length of database: 18,247,518
effective HSP length: 110
effective length of query: 678
effective length of database: 14,082,258
effective search space: 9547770924
effective search space used: 9547770924
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.