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Search of human proteins with 20270373
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20270373 T-cell activation Rho GTPase-activating protein
isoform c [Homo sapiens]
(266 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20270373 T-cell activation Rho GTPase-activating protein isof... 524 e-149
gi|21314774 T-cell activation Rho GTPase-activating protein isof... 515 e-146
gi|23199971 T-cell activation Rho GTPase-activating protein isof... 166 2e-41
gi|51479148 Rho GTPase activating protein 20 [Homo sapiens] 153 2e-37
gi|4757766 Rho GTPase activating protein 1 [Homo sapiens] 99 3e-21
gi|156119615 myosin IXA [Homo sapiens] 98 7e-21
gi|85815829 SH3-domain binding protein 1 [Homo sapiens] 96 3e-20
gi|54860079 nadrin isoform 1 [Homo sapiens] 91 8e-19
gi|54860105 nadrin isoform 2 [Homo sapiens] 91 8e-19
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens] 91 1e-18
gi|226423858 PRR5-ARHGAP8 fusion protein [Homo sapiens] 88 7e-18
gi|66346660 Rho GTPase activating protein 8 isoform 2 [Homo sapi... 88 7e-18
gi|66346662 Rho GTPase activating protein 8 isoform 1 [Homo sapi... 88 7e-18
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 79 3e-15
gi|194272142 myosin IXB isoform 2 [Homo sapiens] 79 4e-15
gi|33356170 myosin IXB isoform 1 [Homo sapiens] 79 4e-15
gi|188497642 ARHGAP15 [Homo sapiens] 77 1e-14
gi|156071465 Rho GTPase activating protein 4 [Homo sapiens] 76 3e-14
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 76 3e-14
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ... 74 1e-13
gi|33188433 deleted in liver cancer 1 isoform 1 [Homo sapiens] 73 2e-13
gi|33188437 deleted in liver cancer 1 isoform 2 [Homo sapiens] 73 2e-13
gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a... 73 2e-13
gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b... 73 2e-13
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 71 1e-12
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 71 1e-12
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi... 70 1e-12
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ... 70 1e-12
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi... 70 2e-12
gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens] 70 2e-12
>gi|20270373 T-cell activation Rho GTPase-activating protein isoform
c [Homo sapiens]
Length = 266
Score = 524 bits (1350), Expect = e-149
Identities = 266/266 (100%), Positives = 266/266 (100%)
Query: 1 MKLRSSHNASKTLNANNMETLIECQSEGDIKEHPLLASCESEDSICQLIEVKKRKKVLSW 60
MKLRSSHNASKTLNANNMETLIECQSEGDIKEHPLLASCESEDSICQLIEVKKRKKVLSW
Sbjct: 1 MKLRSSHNASKTLNANNMETLIECQSEGDIKEHPLLASCESEDSICQLIEVKKRKKVLSW 60
Query: 61 PFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRPIQDILTILCLKGPSTEG 120
PFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRPIQDILTILCLKGPSTEG
Sbjct: 61 PFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRPIQDILTILCLKGPSTEG 120
Query: 121 IFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMG 180
IFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMG
Sbjct: 121 IFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMG 180
Query: 181 ALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPN 240
ALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPN
Sbjct: 181 ALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPN 240
Query: 241 MLTLENDQSLSFEAQKDLNNKVCSAY 266
MLTLENDQSLSFEAQKDLNNKVCSAY
Sbjct: 241 MLTLENDQSLSFEAQKDLNNKVCSAY 266
>gi|21314774 T-cell activation Rho GTPase-activating protein isoform
b [Homo sapiens]
Length = 731
Score = 515 bits (1326), Expect = e-146
Identities = 262/262 (100%), Positives = 262/262 (100%)
Query: 1 MKLRSSHNASKTLNANNMETLIECQSEGDIKEHPLLASCESEDSICQLIEVKKRKKVLSW 60
MKLRSSHNASKTLNANNMETLIECQSEGDIKEHPLLASCESEDSICQLIEVKKRKKVLSW
Sbjct: 1 MKLRSSHNASKTLNANNMETLIECQSEGDIKEHPLLASCESEDSICQLIEVKKRKKVLSW 60
Query: 61 PFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRPIQDILTILCLKGPSTEG 120
PFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRPIQDILTILCLKGPSTEG
Sbjct: 61 PFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRPIQDILTILCLKGPSTEG 120
Query: 121 IFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMG 180
IFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMG
Sbjct: 121 IFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMG 180
Query: 181 ALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPN 240
ALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPN
Sbjct: 181 ALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPN 240
Query: 241 MLTLENDQSLSFEAQKDLNNKV 262
MLTLENDQSLSFEAQKDLNNKV
Sbjct: 241 MLTLENDQSLSFEAQKDLNNKV 262
>gi|23199971 T-cell activation Rho GTPase-activating protein isoform
a [Homo sapiens]
Length = 553
Score = 166 bits (420), Expect = 2e-41
Identities = 84/84 (100%), Positives = 84/84 (100%)
Query: 179 MGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIG 238
MGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIG
Sbjct: 1 MGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIG 60
Query: 239 PNMLTLENDQSLSFEAQKDLNNKV 262
PNMLTLENDQSLSFEAQKDLNNKV
Sbjct: 61 PNMLTLENDQSLSFEAQKDLNNKV 84
>gi|51479148 Rho GTPase activating protein 20 [Homo sapiens]
Length = 1191
Score = 153 bits (386), Expect = 2e-37
Identities = 81/220 (36%), Positives = 139/220 (63%), Gaps = 3/220 (1%)
Query: 23 ECQSEGDIKEHPLLASCESEDSICQLIEVKKRKKVLSWPFLMRRLSPASDFSGALETDLK 82
E Q + +K L A+ + DS + K+R+ +++W F + + + + +
Sbjct: 302 EMQCQFILKPSRLAAAQQLSDSGHKTF--KRRRSIINWAFWRGSSTHLDNLPSSPTSPMP 359
Query: 83 ASLFDQPLSIICGDSDTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGD 142
LF L IC ++D LP+P+ D+L L KGP T+GIFR++AN K+ +ELKE+LNSG
Sbjct: 360 GQLFGISLPNIC-ENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGV 418
Query: 143 AVDLERLPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLP 202
V L+ + ++A V KDFLR+IP + SSDL++ W+ ++ ++E++I ++++ D+LP
Sbjct: 419 EVHLDCESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLP 478
Query: 203 RPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPNML 242
R N++LL++L VLH I ++S N+M + NLA+C+ P++L
Sbjct: 479 RANVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSIL 518
>gi|4757766 Rho GTPase activating protein 1 [Homo sapiens]
Length = 439
Score = 99.4 bits (246), Expect = 3e-21
Identities = 58/165 (35%), Positives = 98/165 (59%), Gaps = 3/165 (1%)
Query: 96 DSDTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERL-PVHLL 154
+ + +P +++ + L +TEGIFRR+AN + +E++++ N G VD ++ +HL
Sbjct: 255 EQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLP 314
Query: 155 AVVFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVY 214
AV+ K FLR +P LL+ DL+ +G L + DE R+ A QV LP N +L+ L
Sbjct: 315 AVILKTFLRELPEPLLTFDLYPHVVGFLNI-DESQRVPATLQVLQTLPEENYQVLRFLTA 373
Query: 215 VLHLISKNSEVNRMDSSNLAICIGPNMLTLENDQSLSFEAQKDLN 259
L IS +S+ N+M ++NLA+ GPN+L + D +++ +A +N
Sbjct: 374 FLVQISAHSDQNKMTNTNLAVVFGPNLLWAK-DAAITLKAINPIN 417
>gi|156119615 myosin IXA [Homo sapiens]
Length = 2548
Score = 98.2 bits (243), Expect = 7e-21
Identities = 57/200 (28%), Positives = 112/200 (56%), Gaps = 9/200 (4%)
Query: 44 SICQLIEVKKRKKVLSWPFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRP 103
S+C+L + KK L + S + +L + F LS + + T+P
Sbjct: 2027 SVCKLCKYACHKKCC--------LKTTAKCSKKYDPELSSRQFGVELSRLTSEDRTVPLV 2078
Query: 104 IQDILTILCLKGPSTEGIFRRAANEKARKELKEELNS-GDAVDLERLPVHLLAVVFKDFL 162
++ ++ + + G TEGI+R++ + KEL++ L++ ++V+L+ +H++A VFK +L
Sbjct: 2079 VEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDYNIHVIASVFKQWL 2138
Query: 163 RSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKN 222
R +P L++ +L+EE++ A+ +Q+ ++ I + V D+L R +L L+ L++ L I+
Sbjct: 2139 RDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLNTLERLIFHLVRIALQ 2198
Query: 223 SEVNRMDSSNLAICIGPNML 242
+ NRM ++ LAI P +L
Sbjct: 2199 EDTNRMSANALAIVFAPCIL 2218
>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
Length = 701
Score = 95.9 bits (237), Expect = 3e-20
Identities = 52/142 (36%), Positives = 85/142 (59%), Gaps = 3/142 (2%)
Query: 103 PIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERL--PVHLLAVVFKD 160
PI+ + +L +G EG+FR AA K LK+ + S D LE H +A K
Sbjct: 292 PIEACVMMLLSEGMKEEGLFRLAAGASVLKRLKQTMAS-DPHSLEEFCSDPHAVAGALKS 350
Query: 161 FLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLIS 220
+LR +P L++ DL+++WM A +++ R++AL++V +LP NL L++L+ L ++
Sbjct: 351 YLRELPEPLMTFDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLA 410
Query: 221 KNSEVNRMDSSNLAICIGPNML 242
+ EVN+M SN+AI +GPN+L
Sbjct: 411 EEQEVNKMTPSNIAIVLGPNLL 432
>gi|54860079 nadrin isoform 1 [Homo sapiens]
Length = 881
Score = 91.3 bits (225), Expect = 8e-19
Identities = 49/150 (32%), Positives = 85/150 (56%), Gaps = 1/150 (0%)
Query: 103 PIQDILTILCLKGPSTEGIFRRAANEKARKELKEELN-SGDAVDLERLPVHLLAVVFKDF 161
PI+ + +L G EG+FR A K+LK L+ S +D H +A K +
Sbjct: 268 PIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSY 327
Query: 162 LRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISK 221
LR +P L++ +L+EEW +QD++ +++ L + KLP N + ++L+ L +++
Sbjct: 328 LRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQ 387
Query: 222 NSEVNRMDSSNLAICIGPNMLTLENDQSLS 251
S+VN+M SN+AI +GPN+L N+ +L+
Sbjct: 388 TSDVNKMTPSNIAIVLGPNLLWARNEGTLA 417
>gi|54860105 nadrin isoform 2 [Homo sapiens]
Length = 803
Score = 91.3 bits (225), Expect = 8e-19
Identities = 49/150 (32%), Positives = 85/150 (56%), Gaps = 1/150 (0%)
Query: 103 PIQDILTILCLKGPSTEGIFRRAANEKARKELKEELN-SGDAVDLERLPVHLLAVVFKDF 161
PI+ + +L G EG+FR A K+LK L+ S +D H +A K +
Sbjct: 268 PIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSY 327
Query: 162 LRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISK 221
LR +P L++ +L+EEW +QD++ +++ L + KLP N + ++L+ L +++
Sbjct: 328 LRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQ 387
Query: 222 NSEVNRMDSSNLAICIGPNMLTLENDQSLS 251
S+VN+M SN+AI +GPN+L N+ +L+
Sbjct: 388 TSDVNKMTPSNIAIVLGPNLLWARNEGTLA 417
>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
Length = 818
Score = 90.5 bits (223), Expect = 1e-18
Identities = 48/142 (33%), Positives = 86/142 (60%), Gaps = 3/142 (2%)
Query: 103 PIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERLPV--HLLAVVFKD 160
PI+ +T+L G EG+FR A + K+LK L+ VD++ H +A K
Sbjct: 271 PIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCC-VVDVQEYSADPHAIAGALKS 329
Query: 161 FLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLIS 220
+LR +P L++ +L++EW+ A +Q+++ +++AL +KLP+ N +++L+ L +S
Sbjct: 330 YLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLS 389
Query: 221 KNSEVNRMDSSNLAICIGPNML 242
+ +VN+M SN+AI +GPN+L
Sbjct: 390 EYQDVNKMTPSNMAIVLGPNLL 411
>gi|226423858 PRR5-ARHGAP8 fusion protein [Homo sapiens]
Length = 555
Score = 88.2 bits (217), Expect = 7e-18
Identities = 48/146 (32%), Positives = 87/146 (59%), Gaps = 2/146 (1%)
Query: 98 DTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERL-PVHLLAV 156
+ +P ++ +T L KG TEG+FRR+A+ + +E++ N G V+ + +H+ AV
Sbjct: 329 ELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAV 388
Query: 157 VFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVL 216
+ K FLR +P+ LL+ +E+ +G + + R+ +Q+ LP N ++L++L+ L
Sbjct: 389 ILKTFLRELPQPLLTFQAYEQILG-ITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFL 447
Query: 217 HLISKNSEVNRMDSSNLAICIGPNML 242
H +S+ S N+M+SSNLA G N++
Sbjct: 448 HAVSRESIFNKMNSSNLACVFGLNLI 473
>gi|66346660 Rho GTPase activating protein 8 isoform 2 [Homo
sapiens]
Length = 433
Score = 88.2 bits (217), Expect = 7e-18
Identities = 48/146 (32%), Positives = 87/146 (59%), Gaps = 2/146 (1%)
Query: 98 DTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERL-PVHLLAV 156
+ +P ++ +T L KG TEG+FRR+A+ + +E++ N G V+ + +H+ AV
Sbjct: 207 ELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAV 266
Query: 157 VFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVL 216
+ K FLR +P+ LL+ +E+ +G + + R+ +Q+ LP N ++L++L+ L
Sbjct: 267 ILKTFLRELPQPLLTFQAYEQILG-ITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFL 325
Query: 217 HLISKNSEVNRMDSSNLAICIGPNML 242
H +S+ S N+M+SSNLA G N++
Sbjct: 326 HAVSRESIFNKMNSSNLACVFGLNLI 351
>gi|66346662 Rho GTPase activating protein 8 isoform 1 [Homo
sapiens]
Length = 464
Score = 88.2 bits (217), Expect = 7e-18
Identities = 48/146 (32%), Positives = 87/146 (59%), Gaps = 2/146 (1%)
Query: 98 DTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERL-PVHLLAV 156
+ +P ++ +T L KG TEG+FRR+A+ + +E++ N G V+ + +H+ AV
Sbjct: 238 ELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAV 297
Query: 157 VFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVL 216
+ K FLR +P+ LL+ +E+ +G + + R+ +Q+ LP N ++L++L+ L
Sbjct: 298 ILKTFLRELPQPLLTFQAYEQILG-ITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFL 356
Query: 217 HLISKNSEVNRMDSSNLAICIGPNML 242
H +S+ S N+M+SSNLA G N++
Sbjct: 357 HAVSRESIFNKMNSSNLACVFGLNLI 382
>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
sapiens]
Length = 1499
Score = 79.3 bits (194), Expect = 3e-15
Identities = 45/163 (27%), Positives = 87/163 (53%), Gaps = 2/163 (1%)
Query: 82 KASLFDQPLSIICGDSDTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSG 141
+++ F PL+ + +P I+ + + G STEGI+R + N+ + L+ + +
Sbjct: 1243 ESNYFGVPLTTVVTPEKPIPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQD 1302
Query: 142 DAVDLER--LPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVAD 199
+DL V+ +A K F +P L+ ++ + + A ++ D E ++ ALK+V
Sbjct: 1303 HNLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLK 1362
Query: 200 KLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPNML 242
K P+ N + K+++ L+ +S N++VN M S NL+IC P ++
Sbjct: 1363 KFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLM 1405
>gi|194272142 myosin IXB isoform 2 [Homo sapiens]
Length = 2022
Score = 79.0 bits (193), Expect = 4e-15
Identities = 46/167 (27%), Positives = 91/167 (54%), Gaps = 2/167 (1%)
Query: 93 ICGDSDTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDA-VDLERLPV 151
+ D ++P ++ +L + + G TEG++R++ +EL++ L + A V LE P+
Sbjct: 1705 LTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPI 1764
Query: 152 HLLAVVFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKH 211
H + V K +LR +P L++ + +++ A+E+ ++++++ A+ V + LP N L+
Sbjct: 1765 HAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLER 1824
Query: 212 LVYVLHLISKNSEVNRMDSSNLAICIGPNMLTLENDQSLSFEAQKDL 258
L++ L ++ +VNRM LAI P +L D S + KD+
Sbjct: 1825 LIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCP-DNSDPLTSMKDV 1870
>gi|33356170 myosin IXB isoform 1 [Homo sapiens]
Length = 2157
Score = 79.0 bits (193), Expect = 4e-15
Identities = 46/167 (27%), Positives = 91/167 (54%), Gaps = 2/167 (1%)
Query: 93 ICGDSDTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDA-VDLERLPV 151
+ D ++P ++ +L + + G TEG++R++ +EL++ L + A V LE P+
Sbjct: 1705 LTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPI 1764
Query: 152 HLLAVVFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKH 211
H + V K +LR +P L++ + +++ A+E+ ++++++ A+ V + LP N L+
Sbjct: 1765 HAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLER 1824
Query: 212 LVYVLHLISKNSEVNRMDSSNLAICIGPNMLTLENDQSLSFEAQKDL 258
L++ L ++ +VNRM LAI P +L D S + KD+
Sbjct: 1825 LIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCP-DNSDPLTSMKDV 1870
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 77.4 bits (189), Expect = 1e-14
Identities = 48/171 (28%), Positives = 87/171 (50%), Gaps = 4/171 (2%)
Query: 81 LKASLFDQPLSIICG-DSDTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELN 139
+K +F L +C ++ T+P ++ + + +G +GI+R + N ++L+ +N
Sbjct: 274 IKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVN 333
Query: 140 SGDAVDLERLP---VHLLAVVFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQ 196
+ ++L+ +H++ K F R +P L FE+++ A++ QD RIEA+K
Sbjct: 334 QEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKS 393
Query: 197 VADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPNMLTLEND 247
+ KLP PN +K L L I + N M + +L I GP +L EN+
Sbjct: 394 LVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENE 444
>gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]
Length = 946
Score = 75.9 bits (185), Expect = 3e-14
Identities = 45/152 (29%), Positives = 81/152 (53%), Gaps = 3/152 (1%)
Query: 100 LPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERLPVHLL---AV 156
+P ++ + + L G EGIFR + + E+++ G+ +E H L A
Sbjct: 520 VPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAG 579
Query: 157 VFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVL 216
V K + RS+ L DLF E + + E++ +R+E + ++ +LP P L++L++L L
Sbjct: 580 VLKLYFRSLEPPLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFL 639
Query: 217 HLISKNSEVNRMDSSNLAICIGPNMLTLENDQ 248
+ +++ S+ N MD NLA+C GP +L + Q
Sbjct: 640 NHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQ 671
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 75.9 bits (185), Expect = 3e-14
Identities = 43/138 (31%), Positives = 74/138 (53%), Gaps = 4/138 (2%)
Query: 114 KGPSTEGIFRRAANEKARKELKEELNSG----DAVDLERLPVHLLAVVFKDFLRSIPRKL 169
+G GI+R N A ++EELN G D D + +++++ + K F R +P L
Sbjct: 1175 RGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPL 1234
Query: 170 LSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMD 229
++D + +++ A +D DR++ LK++ LP + LK L L +++NSE N+M+
Sbjct: 1235 FTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKME 1294
Query: 230 SSNLAICIGPNMLTLEND 247
NLAI GP ++ D
Sbjct: 1295 PRNLAIVFGPTLVRTSED 1312
>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a
[Homo sapiens]
Length = 1099
Score = 74.3 bits (181), Expect = 1e-13
Identities = 47/192 (24%), Positives = 94/192 (48%), Gaps = 12/192 (6%)
Query: 61 PFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDS-DTLPRPIQDILTILCLKGPSTE 119
P MRR P S +S LF+ + DS +P ++ + + L G +
Sbjct: 487 PQKMRRPRPLSVYSH--------KLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQ 538
Query: 120 GIFRRAANEKARKELKEELNSGD---AVDLERLPVHLLAVVFKDFLRSIPRKLLSSDLFE 176
GIFR ++ ++K G+ D ++ +A V K + R + L + F+
Sbjct: 539 GIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQ 598
Query: 177 EWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAIC 236
+ + +++++ +R+ ++Q+ LPR ++++++L L+ +S+ S+ N MD NLAIC
Sbjct: 599 DLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAIC 658
Query: 237 IGPNMLTLENDQ 248
GP ++ + + Q
Sbjct: 659 FGPTLMHIPDGQ 670
>gi|33188433 deleted in liver cancer 1 isoform 1 [Homo sapiens]
Length = 1528
Score = 73.2 bits (178), Expect = 2e-13
Identities = 71/281 (25%), Positives = 126/281 (44%), Gaps = 37/281 (13%)
Query: 4 RSSHNASKTLNANNMETLIECQSEGDIKEHPLLASCESEDSICQLIE--VKKRKKVLSW- 60
+SSH S N++ I CQS + L S + L+E K SW
Sbjct: 1006 QSSHRPS----LNSVSLQINCQSVAQMN----LLQKYSLLKLTALLEKYTPSNKHGFSWA 1057
Query: 61 -PFLMRRLSPASDFSGALETDLKASLFDQPLSI-ICGDSDTLPRPIQDILTILCLKGPST 118
P M+R+ D+ S+F PL++ + LP+ IQ + L
Sbjct: 1058 VPKFMKRIK-VPDYKDR-------SVFGVPLTVNVQRTGQPLPQSIQQAMRYLRNHCLDQ 1109
Query: 119 EGIFRRAANEKARKELKEELNSG--DAVDLERLPVHLLAVVFKDFLRSIPRKLLSSDLFE 176
G+FR++ K+R + ++N G D V+ E + +A + K + R +P L+++ L E
Sbjct: 1110 VGLFRKSG-VKSRIQALRQMNEGAIDCVNYEGQSAYDVADMLKQYFRDLPEPLMTNKLSE 1168
Query: 177 EWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAIC 236
++ + ++ R++A+K LP N +L+ L+Y L ++ + N+M +NLA+C
Sbjct: 1169 TFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVC 1228
Query: 237 IGPNML-------------TLENDQSLSFEAQKDLNNKVCS 264
+ P++ ++ QSL QKDLN + +
Sbjct: 1229 LAPSLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAA 1269
>gi|33188437 deleted in liver cancer 1 isoform 2 [Homo sapiens]
Length = 1091
Score = 73.2 bits (178), Expect = 2e-13
Identities = 71/281 (25%), Positives = 126/281 (44%), Gaps = 37/281 (13%)
Query: 4 RSSHNASKTLNANNMETLIECQSEGDIKEHPLLASCESEDSICQLIE--VKKRKKVLSW- 60
+SSH S N++ I CQS + L S + L+E K SW
Sbjct: 569 QSSHRPS----LNSVSLQINCQSVAQMN----LLQKYSLLKLTALLEKYTPSNKHGFSWA 620
Query: 61 -PFLMRRLSPASDFSGALETDLKASLFDQPLSI-ICGDSDTLPRPIQDILTILCLKGPST 118
P M+R+ D+ S+F PL++ + LP+ IQ + L
Sbjct: 621 VPKFMKRIK-VPDYKDR-------SVFGVPLTVNVQRTGQPLPQSIQQAMRYLRNHCLDQ 672
Query: 119 EGIFRRAANEKARKELKEELNSG--DAVDLERLPVHLLAVVFKDFLRSIPRKLLSSDLFE 176
G+FR++ K+R + ++N G D V+ E + +A + K + R +P L+++ L E
Sbjct: 673 VGLFRKSG-VKSRIQALRQMNEGAIDCVNYEGQSAYDVADMLKQYFRDLPEPLMTNKLSE 731
Query: 177 EWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAIC 236
++ + ++ R++A+K LP N +L+ L+Y L ++ + N+M +NLA+C
Sbjct: 732 TFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVC 791
Query: 237 IGPNML-------------TLENDQSLSFEAQKDLNNKVCS 264
+ P++ ++ QSL QKDLN + +
Sbjct: 792 LAPSLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAA 832
>gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a
[Homo sapiens]
Length = 1071
Score = 73.2 bits (178), Expect = 2e-13
Identities = 44/162 (27%), Positives = 84/162 (51%), Gaps = 4/162 (2%)
Query: 97 SDTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGD---AVDLERLPVHL 153
S +P ++ + + G EGIFR + ++ ++K G+ A D +
Sbjct: 501 SQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDS 560
Query: 154 LAVVFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLV 213
+A V K + R + L D+F + M + M + ++R +++V LP+ L+++++L
Sbjct: 561 IAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLF 620
Query: 214 YVLHLISKNSEVNRMDSSNLAICIGPNMLTL-ENDQSLSFEA 254
L+ +S+ SE N MD NLAIC GP+++++ E +S +A
Sbjct: 621 AFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQA 662
>gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b
[Homo sapiens]
Length = 836
Score = 73.2 bits (178), Expect = 2e-13
Identities = 44/162 (27%), Positives = 84/162 (51%), Gaps = 4/162 (2%)
Query: 97 SDTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGD---AVDLERLPVHL 153
S +P ++ + + G EGIFR + ++ ++K G+ A D +
Sbjct: 501 SQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDS 560
Query: 154 LAVVFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLV 213
+A V K + R + L D+F + M + M + ++R +++V LP+ L+++++L
Sbjct: 561 IAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLF 620
Query: 214 YVLHLISKNSEVNRMDSSNLAICIGPNMLTL-ENDQSLSFEA 254
L+ +S+ SE N MD NLAIC GP+++++ E +S +A
Sbjct: 621 AFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQA 662
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 70.9 bits (172), Expect = 1e-12
Identities = 43/173 (24%), Positives = 89/173 (51%), Gaps = 4/173 (2%)
Query: 81 LKASLFDQPLSIICG-DSDTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELN 139
+K +F L+ +C + +PR +Q + + +G +G++R + N ++L+ +++
Sbjct: 322 IKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVD 381
Query: 140 SGDAVDLER---LPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQ 196
+ +DL+ VH++ K F R +P L F +++ A+++QD+ R ++
Sbjct: 382 HDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRD 441
Query: 197 VADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPNMLTLENDQS 249
+ LP PN L+ L L + ++ E NRM ++AI GP +L E +++
Sbjct: 442 LVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEET 494
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 70.9 bits (172), Expect = 1e-12
Identities = 43/173 (24%), Positives = 89/173 (51%), Gaps = 4/173 (2%)
Query: 81 LKASLFDQPLSIICG-DSDTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELN 139
+K +F L+ +C + +PR +Q + + +G +G++R + N ++L+ +++
Sbjct: 349 IKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVD 408
Query: 140 SGDAVDLER---LPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQ 196
+ +DL+ VH++ K F R +P L F +++ A+++QD+ R ++
Sbjct: 409 HDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRD 468
Query: 197 VADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPNMLTLENDQS 249
+ LP PN L+ L L + ++ E NRM ++AI GP +L E +++
Sbjct: 469 LVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEET 521
>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
Length = 1501
Score = 70.5 bits (171), Expect = 1e-12
Identities = 47/209 (22%), Positives = 102/209 (48%), Gaps = 4/209 (1%)
Query: 47 QLIEVKKRKKVLSWPFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRPIQD 106
Q ++ KK KK ++ +F+ + +++ F PL + +P ++
Sbjct: 1220 QELDDKKMKKKTHKVKEDKKKKKTKNFNPPTRRNWESNYFGMPLQDLVTAEKPIPLFVEK 1279
Query: 107 ILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVV--FKDFLRS 164
+ + G TEG++R + N+ + ++++ + ++L + V + AV K F
Sbjct: 1280 CVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSMEVTVNAVAGALKAFFAD 1339
Query: 165 IPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSE 224
+P L+ L E + A ++ D+ +R+ ALK++ K N + ++++ L+ +S+ +
Sbjct: 1340 LPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQHK 1399
Query: 225 VNRMDSSNLAICIGPNML--TLENDQSLS 251
+N M + NL+IC P ++ EN + LS
Sbjct: 1400 INLMTADNLSICFWPTLMRPDFENREFLS 1428
>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b
[Homo sapiens]
Length = 1075
Score = 70.5 bits (171), Expect = 1e-12
Identities = 36/152 (23%), Positives = 80/152 (52%), Gaps = 3/152 (1%)
Query: 100 LPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGD---AVDLERLPVHLLAV 156
+P ++ + + L G +GIFR ++ ++K G+ D ++ +A
Sbjct: 495 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 554
Query: 157 VFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVL 216
V K + R + L + F++ + +++++ +R+ ++Q+ LPR ++++++L L
Sbjct: 555 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 614
Query: 217 HLISKNSEVNRMDSSNLAICIGPNMLTLENDQ 248
+ +S+ S+ N MD NLAIC GP ++ + + Q
Sbjct: 615 NHLSQYSDENMMDPYNLAICFGPTLMHIPDGQ 646
>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
Length = 1502
Score = 70.1 bits (170), Expect = 2e-12
Identities = 46/209 (22%), Positives = 102/209 (48%), Gaps = 4/209 (1%)
Query: 47 QLIEVKKRKKVLSWPFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRPIQD 106
+L + K +KK ++ +F+ + +++ F PL + +P ++
Sbjct: 1221 ELDDKKMKKKTHKVKEDKKQKKKTKNFNPPTRRNWESNYFGMPLQDLVTAEKPIPLFVEK 1280
Query: 107 ILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVV--FKDFLRS 164
+ + G TEG++R + N+ + ++++ + ++L + V + AV K F
Sbjct: 1281 CVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSMEVTVNAVAGALKAFFAD 1340
Query: 165 IPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSE 224
+P L+ L E + A ++ D+ +R+ ALK++ K N + ++++ L+ +S+ +
Sbjct: 1341 LPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQHK 1400
Query: 225 VNRMDSSNLAICIGPNML--TLENDQSLS 251
+N M + NL+IC P ++ EN + LS
Sbjct: 1401 INLMTADNLSICFWPTLMRPDFENREFLS 1429
>gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens]
Length = 771
Score = 69.7 bits (169), Expect = 2e-12
Identities = 50/168 (29%), Positives = 85/168 (50%), Gaps = 13/168 (7%)
Query: 100 LPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERL-PVHLLAVVF 158
+PR + L G T GIFR +++K ++L+EE + G V LE VH +A +
Sbjct: 207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALL 266
Query: 159 KDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHL 218
K+FLR +P LL+ +L+ ++ L ++ EE ++ L+ + LP N L L+ L +
Sbjct: 267 KEFLRDMPDPLLTRELYTAFINTLLLEPEE-QLGTLQLLIYLLPPCNCDTLHRLLQFLSI 325
Query: 219 ISKNSE-----------VNRMDSSNLAICIGPNMLTLENDQSLSFEAQ 255
++++++ N+M S NLA GPN+L + F Q
Sbjct: 326 VARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQ 373
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,911,588
Number of Sequences: 37866
Number of extensions: 424807
Number of successful extensions: 1237
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 1072
Number of HSP's gapped (non-prelim): 126
length of query: 266
length of database: 18,247,518
effective HSP length: 100
effective length of query: 166
effective length of database: 14,460,918
effective search space: 2400512388
effective search space used: 2400512388
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.