Search of human proteins with 20149619

Search of human proteins with 20149619

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20149619 dehydrogenase/reductase (SDR family) member 7B
[Homo sapiens]
         (325 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...   630   0.0  
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom...   251   6e-67
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...   150   2e-36
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]         103   2e-22
gi|150247226 retinol dehydrogenase 16 [Homo sapiens]                  102   5e-22
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]        100   3e-21
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]    94   2e-19
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    91   1e-18
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...    91   1e-18
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...    91   1e-18
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...    91   1e-18
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    91   1e-18
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]           88   1e-17
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]      86   3e-17
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]       86   3e-17
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...    83   3e-16
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo...    82   5e-16
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom...    82   5e-16
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom...    82   5e-16
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo...    82   5e-16
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]        82   6e-16
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap...    82   8e-16
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]    81   1e-15
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...    80   2e-15
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi...    80   2e-15
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ...    80   2e-15
gi|223646115 short chain dehydrogenase/reductase family 16C, mem...    79   4e-15
gi|40254992 carbonic reductase 4 [Homo sapiens]                        78   1e-14
gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo sapi...    75   6e-14
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B...    75   8e-14

>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score =  630 bits (1626), Expect = 0.0
 Identities = 325/325 (100%), Positives = 325/325 (100%)

Query: 1   MVSPATRKSLPKVKAMDFITSTAILPLLFGCLGVFGLFRLLQWVRGKAYLRNAVVVITGA 60
           MVSPATRKSLPKVKAMDFITSTAILPLLFGCLGVFGLFRLLQWVRGKAYLRNAVVVITGA
Sbjct: 1   MVSPATRKSLPKVKAMDFITSTAILPLLFGCLGVFGLFRLLQWVRGKAYLRNAVVVITGA 60

Query: 61  TSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSG 120
           TSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSG
Sbjct: 61  TSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSG 120

Query: 121 AIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPS 180
           AIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPS
Sbjct: 121 AIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPS 180

Query: 181 MIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYI 240
           MIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYI
Sbjct: 181 MIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYI 240

Query: 241 HTNLSVNAITADGSRYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILADLLPSLAVYL 300
           HTNLSVNAITADGSRYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILADLLPSLAVYL
Sbjct: 241 HTNLSVNAITADGSRYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILADLLPSLAVYL 300

Query: 301 RTLAPGLFFSLMASRARKERKSKNS 325
           RTLAPGLFFSLMASRARKERKSKNS
Sbjct: 301 RTLAPGLFFSLMASRARKERKSKNS 325


>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
           sapiens]
          Length = 311

 Score =  251 bits (641), Expect = 6e-67
 Identities = 135/305 (44%), Positives = 197/305 (64%), Gaps = 7/305 (2%)

Query: 19  ITSTAILPLLFGCLGVFGLFRLLQWVR---GKAYLRNAVVVITGATSGLGKECAKVFYAA 75
           + +  +LPLL   LG+ GL  + Q V     K+ ++N VVVIT A SGLGKECA+VF+  
Sbjct: 3   VMAMLMLPLLL--LGISGLLFIYQEVSRLWSKSAVQNKVVVITDAISGLGKECARVFHTG 60

Query: 76  GAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGY 135
           GA+LVLCG+N   LE L   L  S A   +T  P LV  DL+D   +   A E+L C+G 
Sbjct: 61  GARLVLCGKNWERLENLYDALI-SVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGC 119

Query: 136 VDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSI 195
           VDIL+NNA +  +G     ++++DK++M+ NYFGP+ LTKALLP+MI RR G IV +++I
Sbjct: 120 VDILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNI 179

Query: 196 QGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHT-NLSVNAITADGS 254
           QGK  IPFR+ YAASKHA   FFDCLRAE+E+Y++ ++ +SP +I + ++       + S
Sbjct: 180 QGKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPTFIRSYHVYPEQGNWEAS 239

Query: 255 RYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILADLLPSLAVYLRTLAPGLFFSLMAS 314
            +         G  PVEVA++V+  V +KK++V +A+ +P  AVY+RT  P  FF+++A 
Sbjct: 240 IWKFFFRKLTYGVHPVEVAEEVMRTVRRKKQEVFMANPIPKAAVYVRTFFPEFFFAVVAC 299

Query: 315 RARKE 319
             +++
Sbjct: 300 GVKEK 304


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score =  150 bits (378), Expect = 2e-36
 Identities = 89/205 (43%), Positives = 125/205 (60%), Gaps = 5/205 (2%)

Query: 50  LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKP 109
           L + VV +TGA+SG+G+E A      G  LVL  R    LE + R    +   K    K 
Sbjct: 48  LTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLK---EKD 104

Query: 110 YLVT-FDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYF 168
            LV   DLTD+G+  AA   +LQ FG +DILVNN G+S R   MDT++DV ++++E NY 
Sbjct: 105 ILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYL 164

Query: 169 GPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQY 228
           G V+LTK +LP MI+R+QG IV ++SI G +S+P    Y ASKHA + FF+ LR E+  Y
Sbjct: 165 GTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATY 224

Query: 229 E-IEVTVISPGYIHTNLSVNAITAD 252
             I V+ I PG + +N+  N++  +
Sbjct: 225 PGIIVSNICPGPVQSNIVENSLAGE 249


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score =  103 bits (257), Expect = 2e-22
 Identities = 80/253 (31%), Positives = 121/253 (47%), Gaps = 36/253 (14%)

Query: 55  VVITGATSGLGKECAKVFYAAGAK---LVLCGRNGGALEELIRELTASHATKVQTHKPYL 111
           V+I+G +SG+G E A        K   +V   R+ G  E L  E  A  A   QT     
Sbjct: 8   VLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETL--EAAAGEALG-QT----- 59

Query: 112 VTFDLTDSGAIVAAAAEILQCF----GYVDILVNNAGISYRGTIMDTTVDVDKRVMETNY 167
               LT +   V +   + QC     G VD+LVNNAG+   G +   ++   + V +TN+
Sbjct: 60  ----LTVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNF 115

Query: 168 FGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQ 227
           FG V L KA+LP M +RRQGHIV ISS+ G   + F   YAASK A + FF+ L  ++ Q
Sbjct: 116 FGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQ 175

Query: 228 YEIEVTVISPGYIHTNLSVNAITADGSRYGVMDTTTAQGRSP----------VEVAQDVL 277
           + I ++++ PG + T         +G     +      G  P          +  ++ + 
Sbjct: 176 FNIFISLVEPGPVVTEF-------EGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLF 228

Query: 278 AAVGKKKKDVILA 290
            +VG+  +DV+ A
Sbjct: 229 CSVGQNPQDVVQA 241


>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
          Length = 317

 Score =  102 bits (254), Expect = 5e-22
 Identities = 74/219 (33%), Positives = 117/219 (53%), Gaps = 20/219 (9%)

Query: 32  LGVF-GLFRLLQWVRGK---AYLRNAVVVITGATSGLGKECAKVFYAAGAK-LVLCGRNG 86
           L VF GL+ LL W R +   ++LR+  V ITG  SG GK  A+   A G + L  C    
Sbjct: 5   LAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEK 64

Query: 87  GALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDI--LVNNAG 144
           GA      +L    + +++T     VT D+T + ++ AAA  + +C     +  LVNNAG
Sbjct: 65  GA-----EQLRGQTSDRLET-----VTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAG 114

Query: 145 ISYRGTIMDTTVDVD-KRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPF 203
           IS      +     D   +++ N  G + +T +LLP +++R +G +V +SS+ G++S+ F
Sbjct: 115 ISLPTAPNELLTKQDFVTILDVNLLGVIDVTLSLLP-LVRRARGRVVNVSSVMGRVSL-F 172

Query: 204 RSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHT 242
              Y  SK+  +AF D LR E+  + ++V +I PGY  T
Sbjct: 173 GGGYCISKYGVEAFSDSLRRELSYFGVKVAMIEPGYFKT 211


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score = 99.8 bits (247), Expect = 3e-21
 Identities = 83/283 (29%), Positives = 127/283 (44%), Gaps = 26/283 (9%)

Query: 24  ILPLLFGCLGVFGLFRLLQWVRGKAYLRNAVVVITGATSGLGKECAKVFYAAGAKLVLCG 83
           +LPLL  C  +    +L    R K+ +   +V+ITGA  G+G+  A  F    +KLVL  
Sbjct: 10  LLPLLIVC-SLESFVKLFIPKRRKS-VTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWD 67

Query: 84  RNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNA 143
            N   LEE   +     A      K +    D ++   I ++A ++    G V ILVNNA
Sbjct: 68  INKHGLEETAAKCKGLGA------KVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNA 121

Query: 144 GISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPF 203
           G+ Y   +  T     ++  E N       TKA LP+M K   GHIV ++S  G +S+PF
Sbjct: 122 GVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPF 181

Query: 204 RSAYAASKHATQAFFDCLRAEMEQYEI---EVTVISPGYIHTNLSVNAITADGSRYGVMD 260
             AY +SK A   F   L  E+   +I   + T + P +++T    N  T+ G       
Sbjct: 182 LLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTL---- 237

Query: 261 TTTAQGRSPVEVAQDVLAAVGKKKKDVILADLLPSLAVYLRTL 303
                   P EV   ++  +  ++K +     +PS   +L TL
Sbjct: 238 -------EPEEVVNRLMHGILTEQKMI----FIPSSIAFLTTL 269


>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
          Length = 317

 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 67/217 (30%), Positives = 115/217 (52%), Gaps = 19/217 (8%)

Query: 36  GLFRLLQWVRGK---AYLRNAVVVITGATSGLGKECAKVFYAAGAK-LVLCGRNGGALEE 91
           GL+ LL W R +   ++L++  V ITG  SG G   A+   A G + L  C    GA   
Sbjct: 10  GLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGA--- 66

Query: 92  LIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDI--LVNNAGISYRG 149
              +L    + +++T     VT D+T   +I AA   + +  G   +  LVNNAGI    
Sbjct: 67  --EQLRGQTSDRLET-----VTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPI 119

Query: 150 TIMDTTVDVDK-RVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYA 208
           T+ +     D   +++ N  G + +T ++LP +++R +G IV +SSI G+++  F   Y 
Sbjct: 120 TLCEWLNTEDSMNMLKVNLIGVIQVTLSMLP-LVRRARGRIVNVSSILGRVAF-FVGGYC 177

Query: 209 ASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHTNLS 245
            SK+  +AF D LR E++ + ++++++ PGY  T ++
Sbjct: 178 VSKYGVEAFSDILRREIQHFGVKISIVEPGYFRTGMT 214


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 61/189 (32%), Positives = 99/189 (52%), Gaps = 3/189 (1%)

Query: 50  LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKP 109
           L  A VV+TG +SG+GK  A   Y  GA + L  RN   L +  +E+        Q    
Sbjct: 30  LPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQV--V 87

Query: 110 YLVTFDLT-DSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYF 168
             ++ D++ D   +     +  +  G VD+LVN AG++  G   D  V   +R+M  NY 
Sbjct: 88  LCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYL 147

Query: 169 GPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQY 228
           G V  ++A++ +M +RR G IV +SS  G++ +   +AY+ASK A +   + L+ E++ Y
Sbjct: 148 GSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPY 207

Query: 229 EIEVTVISP 237
            + +TV  P
Sbjct: 208 NVYITVAYP 216


>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 62/187 (33%), Positives = 107/187 (57%), Gaps = 8/187 (4%)

Query: 55  VVITGATSGLGKECAKVFYAAGAKLVLCG---RNGGALEELIRELTASHATKVQTHKPYL 111
           V++TG  SG G   AK  ++ G  LV  G   ++ G   + ++EL + ++ +++T +  +
Sbjct: 58  VLVTGCDSGFGFSLAKHLHSKGF-LVFAGCLMKDKG--HDGVKELDSLNSDRLRTVQLNV 114

Query: 112 VTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPV 171
            + +  +   +    + +      +  LVNNAGIS  G +  T+++  K+V E N +G V
Sbjct: 115 CSSEEVEK-VVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTV 173

Query: 172 ALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIE 231
            +TK+ LP +I+R +G +V ISS+ G+M+ P RS Y  +K   +AF DCLR EM    ++
Sbjct: 174 RMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVK 232

Query: 232 VTVISPG 238
           V+V+ PG
Sbjct: 233 VSVVEPG 239


>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 62/187 (33%), Positives = 107/187 (57%), Gaps = 8/187 (4%)

Query: 55  VVITGATSGLGKECAKVFYAAGAKLVLCG---RNGGALEELIRELTASHATKVQTHKPYL 111
           V++TG  SG G   AK  ++ G  LV  G   ++ G   + ++EL + ++ +++T +  +
Sbjct: 58  VLVTGCDSGFGFSLAKHLHSKGF-LVFAGCLMKDKG--HDGVKELDSLNSDRLRTVQLNV 114

Query: 112 VTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPV 171
            + +  +   +    + +      +  LVNNAGIS  G +  T+++  K+V E N +G V
Sbjct: 115 CSSEEVEK-VVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTV 173

Query: 172 ALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIE 231
            +TK+ LP +I+R +G +V ISS+ G+M+ P RS Y  +K   +AF DCLR EM    ++
Sbjct: 174 RMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVK 232

Query: 232 VTVISPG 238
           V+V+ PG
Sbjct: 233 VSVVEPG 239


>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 62/187 (33%), Positives = 107/187 (57%), Gaps = 8/187 (4%)

Query: 55  VVITGATSGLGKECAKVFYAAGAKLVLCG---RNGGALEELIRELTASHATKVQTHKPYL 111
           V++TG  SG G   AK  ++ G  LV  G   ++ G   + ++EL + ++ +++T +  +
Sbjct: 58  VLVTGCDSGFGFSLAKHLHSKGF-LVFAGCLMKDKG--HDGVKELDSLNSDRLRTVQLNV 114

Query: 112 VTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPV 171
            + +  +   +    + +      +  LVNNAGIS  G +  T+++  K+V E N +G V
Sbjct: 115 CSSEEVEK-VVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTV 173

Query: 172 ALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIE 231
            +TK+ LP +I+R +G +V ISS+ G+M+ P RS Y  +K   +AF DCLR EM    ++
Sbjct: 174 RMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVK 232

Query: 232 VTVISPG 238
           V+V+ PG
Sbjct: 233 VSVVEPG 239


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 64/201 (31%), Positives = 104/201 (51%), Gaps = 11/201 (5%)

Query: 54  VVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQ-THKPYLV 112
           +V+ITGA  G+G++    F    + LVL   N   +EE     TA+   K+  T   Y+V
Sbjct: 38  IVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEE-----TAAECRKLGVTAHAYVV 92

Query: 113 TFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVA 172
             D ++   I  +  ++ +  G V I+VNNAG  Y   ++ T  +   +  E N  G   
Sbjct: 93  --DCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFW 150

Query: 173 LTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEME---QYE 229
           +TKALLPSM++R  GHIV ++S+ G   IP+   Y +SK A   F   L +E++   +  
Sbjct: 151 ITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTG 210

Query: 230 IEVTVISPGYIHTNLSVNAIT 250
           I+ + + P +++T  + N  T
Sbjct: 211 IKTSCLCPVFVNTGFTKNPST 231


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 70/255 (27%), Positives = 119/255 (46%), Gaps = 17/255 (6%)

Query: 54  VVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVT 113
           +V+ITGA SGLG+  A  F   G+ LVL   N    EE  +    + AT+V  +     T
Sbjct: 42  IVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAY-----T 96

Query: 114 FDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVAL 173
            D +    +   A ++ +  G V IL+NNAGI      +D   ++ ++  + N+   +  
Sbjct: 97  CDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWT 156

Query: 174 TKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAE---MEQYEI 230
            KA LP+MI    GH+V ISS  G   +   + Y ASK A   F + +  E    +Q  I
Sbjct: 157 YKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGI 216

Query: 231 EVTVISPGYIHTNLSVNAITADGSRYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILA 290
           + T++ P +I T +     T   S   +++        P    + ++ A+ ++K  + + 
Sbjct: 217 KTTIVCPFFIKTGMFEGCTTGCPSLLPILE--------PKYAVEKIVEAILQEKMYLYMP 268

Query: 291 DLLPSLAVYLRTLAP 305
            LL    ++L++  P
Sbjct: 269 KLL-YFMMFLKSFLP 282


>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 86.3 bits (212), Expect = 3e-17
 Identities = 56/203 (27%), Positives = 103/203 (50%), Gaps = 8/203 (3%)

Query: 50  LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKP 109
           L+   V++TGA+ G+G+E A      GA +V+  R+   L++++     SH  ++     
Sbjct: 32  LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVV-----SHCLELGAASA 86

Query: 110 YLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFG 169
           + +   + D        A+  +  G +D+L+ N   +    +    +   ++ ME N+  
Sbjct: 87  HYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLS 146

Query: 170 PVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAE--MEQ 227
            V LT A LP M+K+  G IV +SS+ GK++ P  +AY+ASK A   FF  +R E  + +
Sbjct: 147 YVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSR 205

Query: 228 YEIEVTVISPGYIHTNLSVNAIT 250
             + +T+   G I T  ++ A++
Sbjct: 206 VNVSITLCVLGLIDTETAMKAVS 228


>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 86.3 bits (212), Expect = 3e-17
 Identities = 56/203 (27%), Positives = 103/203 (50%), Gaps = 8/203 (3%)

Query: 50  LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKP 109
           L+   V++TGA+ G+G+E A      GA +V+  R+   L++++     SH  ++     
Sbjct: 32  LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVV-----SHCLELGAASA 86

Query: 110 YLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFG 169
           + +   + D        A+  +  G +D+L+ N   +    +    +   ++ ME N+  
Sbjct: 87  HYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLS 146

Query: 170 PVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAE--MEQ 227
            V LT A LP M+K+  G IV +SS+ GK++ P  +AY+ASK A   FF  +R E  + +
Sbjct: 147 YVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSR 205

Query: 228 YEIEVTVISPGYIHTNLSVNAIT 250
             + +T+   G I T  ++ A++
Sbjct: 206 VNVSITLCVLGLIDTETAMKAVS 228


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 62/206 (30%), Positives = 96/206 (46%), Gaps = 25/206 (12%)

Query: 50  LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIREL---------TASH 100
           L N V ++T +T G+G   A+     GA +V+  R    +++ +  L         T  H
Sbjct: 30  LANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCH 89

Query: 101 ATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGIS-YRGTIMDTTVDVD 159
             K +            D   +VA A ++    G +DILV+NA ++ + G+IMD T +V 
Sbjct: 90  VGKAE------------DRERLVATAVKL---HGGIDILVSNAAVNPFFGSIMDVTEEVW 134

Query: 160 KRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFD 219
            + ++ N   P  +TKA++P M KR  G +V +SSI      P  S Y  SK A      
Sbjct: 135 DKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTK 194

Query: 220 CLRAEMEQYEIEVTVISPGYIHTNLS 245
            L  E+    I V  ++PG I T+ S
Sbjct: 195 TLAIELAPRNIRVNCLAPGLIKTSFS 220


>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 66/228 (28%), Positives = 113/228 (49%), Gaps = 23/228 (10%)

Query: 27  LLFGCLGVFGLFRLLQWVRGKAYLRNAV---VVITGATSGLGKECAKVFYAAGAKLVL-C 82
           +LF  LG+  L   L   +GK  + +     + ITG  SG G   A+ F   G  ++  C
Sbjct: 1   MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60

Query: 83  GRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDI--LV 140
               G+       L A  + +++T     V  D+TD   +   A  +    G   +  L+
Sbjct: 61  LTESGSTA-----LKAETSERLRT-----VLLDVTDPENVKRTAQWVKNQVGEKGLWGLI 110

Query: 141 NNAGISYRGTIMDT---TVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQG 197
           NNAG+   G +  T   T++  +  +E N FG +++T  +LP ++K+ QG ++ +SS+ G
Sbjct: 111 NNAGVP--GVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGG 167

Query: 198 KMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHTNLS 245
           +++I     Y  SK+A + F D LR +M+ + + V+ I PG   TNL+
Sbjct: 168 RLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLA 214


>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 66/228 (28%), Positives = 113/228 (49%), Gaps = 23/228 (10%)

Query: 27  LLFGCLGVFGLFRLLQWVRGKAYLRNAV---VVITGATSGLGKECAKVFYAAGAKLVL-C 82
           +LF  LG+  L   L   +GK  + +     + ITG  SG G   A+ F   G  ++  C
Sbjct: 1   MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60

Query: 83  GRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDI--LV 140
               G+       L A  + +++T     V  D+TD   +   A  +    G   +  L+
Sbjct: 61  LTESGSTA-----LKAETSERLRT-----VLLDVTDPENVKRTAQWVKNQVGEKGLWGLI 110

Query: 141 NNAGISYRGTIMDT---TVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQG 197
           NNAG+   G +  T   T++  +  +E N FG +++T  +LP ++K+ QG ++ +SS+ G
Sbjct: 111 NNAGVP--GVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGG 167

Query: 198 KMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHTNLS 245
           +++I     Y  SK+A + F D LR +M+ + + V+ I PG   TNL+
Sbjct: 168 RLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLA 214


>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 66/228 (28%), Positives = 113/228 (49%), Gaps = 23/228 (10%)

Query: 27  LLFGCLGVFGLFRLLQWVRGKAYLRNAV---VVITGATSGLGKECAKVFYAAGAKLVL-C 82
           +LF  LG+  L   L   +GK  + +     + ITG  SG G   A+ F   G  ++  C
Sbjct: 1   MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60

Query: 83  GRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDI--LV 140
               G+       L A  + +++T     V  D+TD   +   A  +    G   +  L+
Sbjct: 61  LTESGSTA-----LKAETSERLRT-----VLLDVTDPENVKRTAQWVKNQVGEKGLWGLI 110

Query: 141 NNAGISYRGTIMDT---TVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQG 197
           NNAG+   G +  T   T++  +  +E N FG +++T  +LP ++K+ QG ++ +SS+ G
Sbjct: 111 NNAGVP--GVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGG 167

Query: 198 KMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHTNLS 245
           +++I     Y  SK+A + F D LR +M+ + + V+ I PG   TNL+
Sbjct: 168 RLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLA 214


>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 66/228 (28%), Positives = 113/228 (49%), Gaps = 23/228 (10%)

Query: 27  LLFGCLGVFGLFRLLQWVRGKAYLRNAV---VVITGATSGLGKECAKVFYAAGAKLVL-C 82
           +LF  LG+  L   L   +GK  + +     + ITG  SG G   A+ F   G  ++  C
Sbjct: 1   MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60

Query: 83  GRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDI--LV 140
               G+       L A  + +++T     V  D+TD   +   A  +    G   +  L+
Sbjct: 61  LTESGSTA-----LKAETSERLRT-----VLLDVTDPENVKRTAQWVKNQVGEKGLWGLI 110

Query: 141 NNAGISYRGTIMDT---TVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQG 197
           NNAG+   G +  T   T++  +  +E N FG +++T  +LP ++K+ QG ++ +SS+ G
Sbjct: 111 NNAGVP--GVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGG 167

Query: 198 KMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHTNLS 245
           +++I     Y  SK+A + F D LR +M+ + + V+ I PG   TNL+
Sbjct: 168 RLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLA 214


>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
          Length = 260

 Score = 82.0 bits (201), Expect = 6e-16
 Identities = 62/201 (30%), Positives = 96/201 (47%), Gaps = 10/201 (4%)

Query: 51  RNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPY 110
           R+ + ++TGA+ G+G   A+     G K+V C R  G +EEL  E     A    T  PY
Sbjct: 10  RDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAE--CKSAGYPGTLIPY 67

Query: 111 LVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGP 170
               DL++   I++  + I      VDI +NNAG++   T++  +    K +   N    
Sbjct: 68  --RCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLAL 125

Query: 171 VALTKALLPSMIKRR--QGHIVAISSIQGKMSIPFRSA--YAASKHATQAFFDCLRAEME 226
              T+    SM +R    GHI+ I+S+ G   +P      Y+A+K+A  A  + LR E+ 
Sbjct: 126 SICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELR 185

Query: 227 --QYEIEVTVISPGYIHTNLS 245
             Q  I  T ISPG + T  +
Sbjct: 186 EAQTHIRATCISPGVVETQFA 206


>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
           sapiens]
          Length = 318

 Score = 81.6 bits (200), Expect = 8e-16
 Identities = 68/225 (30%), Positives = 111/225 (49%), Gaps = 24/225 (10%)

Query: 25  LPLLFGCLGVFGLFRLLQWVRGKAYL--RNAVVVITGATSGLGKECAKVFYAAGAKLVLC 82
           LPLL G L    L+ +L  +R +  L   NA V ITG  SG G+  A      G +++  
Sbjct: 3   LPLLLGAL----LWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLAS 58

Query: 83  GRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDI--LV 140
                  E+L R         V + + +    D+TD  ++  AA  +        +  LV
Sbjct: 59  CLTPSGAEDLQR---------VASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLV 109

Query: 141 NNAGISYRGTIMDT---TVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQG 197
           NNAG++  G I  T   T D  +RV+  N  GP+ +T ALLP ++++ +G ++ I+S+ G
Sbjct: 110 NNAGVA--GIIGPTPWLTRDDFQRVLNVNTMGPIGVTLALLP-LLQQARGRVINITSVLG 166

Query: 198 KMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHT 242
           +++      Y  SK   +AF D LR ++  + I V+++ PG+  T
Sbjct: 167 RLAAN-GGGYCVSKFGLEAFSDSLRRDVAHFGIRVSIVEPGFFRT 210


>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
          Length = 312

 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 56/194 (28%), Positives = 92/194 (47%), Gaps = 11/194 (5%)

Query: 56  VITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFD 115
           V+TG+T G+GK  A+     G K+VL  R+   L+++  E+      + +T      + D
Sbjct: 54  VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASED 113

Query: 116 LTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTV----DVDKRVMETNYFGPV 171
           + D      A  EI        ILVNN G+SY        V    +V K+++  N     
Sbjct: 114 IYDKIKTGLAGLEI-------GILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVC 166

Query: 172 ALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIE 231
            +T+ +LP M++R +G I+ ISS  G + +P  + Y+A+K     F  CL  E     + 
Sbjct: 167 KMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVF 226

Query: 232 VTVISPGYIHTNLS 245
           V  + P ++ T L+
Sbjct: 227 VQSVLPYFVATKLA 240


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 56/192 (29%), Positives = 92/192 (47%), Gaps = 12/192 (6%)

Query: 54  VVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVT 113
           VVV+TG   G+G    + F  +GA++V+C ++      L +EL  +            + 
Sbjct: 11  VVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGA----------VFIL 60

Query: 114 FDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMD-TTVDVDKRVMETNYFGPVA 172
            D+T    +    +E ++ FG +D +VNNAG        + T+    ++++E N  G   
Sbjct: 61  CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT 120

Query: 173 LTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEV 232
           LTK  LP  +++ QG+++ ISS+ G +       Y A+K A  A    L  +   Y + V
Sbjct: 121 LTKLALP-YLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRV 179

Query: 233 TVISPGYIHTNL 244
             ISPG I T L
Sbjct: 180 NCISPGNIWTPL 191


>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
           sapiens]
          Length = 328

 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 58/213 (27%), Positives = 96/213 (45%), Gaps = 5/213 (2%)

Query: 50  LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKP 109
           +   VV+ITG +SG+G   A    +  ++          L+   R   A+ A        
Sbjct: 1   MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL 60

Query: 110 YLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFG 169
             +  D+ DS ++ AA   + +  G VD+LV NAG+   G +     D    V++ N  G
Sbjct: 61  ETLQLDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVG 118

Query: 170 PVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYE 229
            V + +A LP M +R  G ++   S+ G M +PF   Y ASK A +   + L   +  + 
Sbjct: 119 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG 178

Query: 230 IEVTVISPGYIHTNLSVNAITADGSRYGVMDTT 262
           + +++I  G +HT      +   GS   V+D T
Sbjct: 179 VHLSLIECGPVHTAFMEKVL---GSPEEVLDRT 208


>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
           sapiens]
          Length = 302

 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 67/248 (27%), Positives = 114/248 (45%), Gaps = 10/248 (4%)

Query: 55  VVITGATSGLGKECAKVFYAAGA-KLVLCGRNGGALEELIRELTASHATKVQTHKPYLVT 113
           V+ITG   G+G++ A+ F   GA K+VL GR    L+E   E+      ++ T   Y + 
Sbjct: 41  VLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIR-----QMGTECHYFIC 95

Query: 114 FDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVAL 173
            D+ +   +   A  + +  G + ILVNNA + +  ++MD+  D   +    N  G    
Sbjct: 96  -DVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWT 154

Query: 174 TKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLR-AEMEQYEIEV 232
           TKA LP M++ + GHIV ++S+    +IP    Y  SK +  AF + L    ++   +  
Sbjct: 155 TKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSA 214

Query: 233 TVISPGYIHTNLSVNAITADGSRYGVMDTTTAQGRS--PVEVAQDVLAAVGKKKKDVILA 290
           T + P +  T +         + +  +   T   R+   V++ Q +L         VIL 
Sbjct: 215 TTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILK 274

Query: 291 DLLPSLAV 298
            +LP  A+
Sbjct: 275 SILPQAAL 282


>gi|223646115 short chain dehydrogenase/reductase family 16C, member
           6 [Homo sapiens]
          Length = 323

 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 76/244 (31%), Positives = 112/244 (45%), Gaps = 26/244 (10%)

Query: 16  MDFITSTAILPLLFGCLGVFGLFRLLQWV-----RGKAYLRNAVVVITGATSGLGKECAK 70
           MD I  T++L      LG F  + L   V     + K  +   +V+ TGA SGLG++ A 
Sbjct: 1   MDVIADTSVL------LGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAI 54

Query: 71  VFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEIL 130
            F   GA LVL   N     E  R        KV    PY  T D ++   +   A ++ 
Sbjct: 55  YFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVF---PY--TCDCSNRQEVYRVADQVR 109

Query: 131 QCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIV 190
           + FG V ILVNNA +      +D    + ++    N        KA LP++IK   GH+V
Sbjct: 110 KEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLV 169

Query: 191 AISSIQGKMSIPFRS-------AYAASKHATQAFFDCLRAEM---EQYEIEVTVISPGYI 240
            ISSI G + I   S        Y+ASK A   F + L  E+   ++ E++ T++ P +I
Sbjct: 170 CISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFI 229

Query: 241 HTNL 244
           +T +
Sbjct: 230 NTGM 233


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 51/192 (26%), Positives = 91/192 (47%), Gaps = 9/192 (4%)

Query: 54  VVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVT 113
           V  + G + G+G+  A++    G +L +  RN    +    +L   H            +
Sbjct: 4   VCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLA---------FS 54

Query: 114 FDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVAL 173
            D+     +     E+ +  G V+ LVN AGI+  G ++ T  +     + TN  G +  
Sbjct: 55  CDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLT 114

Query: 174 TKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVT 233
            KA + +MI+++ G IV + SI G      +S Y+ASK     F   L  E+ + +I V 
Sbjct: 115 CKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVN 174

Query: 234 VISPGYIHTNLS 245
           V++PG++HT+++
Sbjct: 175 VVAPGFVHTDMT 186


>gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo
           sapiens]
          Length = 405

 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 89/329 (27%), Positives = 141/329 (42%), Gaps = 48/329 (14%)

Query: 9   SLPKVKAMDFITSTAILP----LLFGCLGVFGLFRLLQWVRGKAYLRNAVVVITGATSGL 64
           +L  + A+D++    + P     +    G   L RL +  R     R   V+ITG  SG 
Sbjct: 37  ALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATR--AVLITGCDSGF 94

Query: 65  GKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQT---HKPYLVTFDLTDSGA 121
           GKE AK   + G  ++            + EL +  A +++T    +  L+  DLT  G 
Sbjct: 95  GKETAKKLDSMGFTVLAT----------VLELNSPGAIELRTCCSPRLRLLQMDLTKPGD 144

Query: 122 I------VAAAAEILQCFGYVDILVNNAGISYRGTIMD---TTVDVDKRVMETNYFGPVA 172
           I        A       +G    LVNNAG  +   + D   + V   +  ME N+FG + 
Sbjct: 145 ISRVLEFTKAHTTSTGLWG----LVNNAG--HNEVVADAELSPVATFRSCMEVNFFGALE 198

Query: 173 LTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEV 232
           LTK LLP +++  +G IV + S  G M  P   AY  SK A     D    E+  + ++V
Sbjct: 199 LTKGLLP-LLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKV 257

Query: 233 TVISPGYIHTNLSVNAITADGSRYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILADL 292
           ++I PG   T  SV  +     R  ++            + Q++L A GK   + +    
Sbjct: 258 SIIQPGCFKTE-SVRNVGQWEKRKQLL---------LANLPQELLQAYGKDYIEHLHGQF 307

Query: 293 LPSLAVYLRTLAP---GLFFSLMASRARK 318
           L SL + +  L P    +  +L+A+R R+
Sbjct: 308 LHSLRLAMSDLTPVVDAITDALLAARPRR 336


>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
           [Homo sapiens]
          Length = 264

 Score = 75.1 bits (183), Expect = 8e-14
 Identities = 42/120 (35%), Positives = 66/120 (55%), Gaps = 3/120 (2%)

Query: 134 GYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAIS 193
           G V I+VNNAG  Y   ++ T  +   +  E N  G   +TKALLPSM++R  GHIV ++
Sbjct: 76  GDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVA 135

Query: 194 SIQGKMSIPFRSAYAASKHATQAFFDCLRAEME---QYEIEVTVISPGYIHTNLSVNAIT 250
           S+ G   IP+   Y +SK A   F   L +E++   +  I+ + + P +++T  + N  T
Sbjct: 136 SVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPST 195


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.134    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,419,487
Number of Sequences: 37866
Number of extensions: 396829
Number of successful extensions: 949
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 792
Number of HSP's gapped (non-prelim): 77
length of query: 325
length of database: 18,247,518
effective HSP length: 102
effective length of query: 223
effective length of database: 14,385,186
effective search space: 3207896478
effective search space used: 3207896478
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.