Search of human proteins with 20149560

Search of human proteins with 20149560

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20149560 syntaxin 4 [Homo sapiens]
         (297 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20149560 syntaxin 4 [Homo sapiens]                                 570   e-163
gi|16418379 syntaxin 1B [Homo sapiens]                                245   4e-65
gi|37577287 syntaxin 2 isoform 1 [Homo sapiens]                       236   1e-62
gi|4759182 syntaxin 1A (brain) [Homo sapiens]                         236   2e-62
gi|37577162 syntaxin 2 isoform 2 [Homo sapiens]                       233   2e-61
gi|4759184 syntaxin 3 [Homo sapiens]                                  213   2e-55
gi|33667038 syntaxin 11 [Homo sapiens]                                118   5e-27
gi|49258196 syntaxin 19 [Homo sapiens]                                117   9e-27
gi|28933465 syntaxin 12 [Homo sapiens]                                 89   6e-18
gi|170932494 syntaxin 7 [Homo sapiens]                                 86   5e-17
gi|198041692 syntaxin 16 isoform d [Homo sapiens]                      70   3e-12
gi|47778943 syntaxin 16 isoform a [Homo sapiens]                       69   5e-12
gi|198041688 syntaxin 16 isoform c [Homo sapiens]                      69   5e-12
gi|34447229 syntaxin 16 isoform b [Homo sapiens]                       69   5e-12
gi|21735548 centrosomal protein 2 [Homo sapiens]                       52   8e-07
gi|112420968 coiled-coil domain containing 158 [Homo sapiens]          51   1e-06
gi|223972648 t-SNARE domain containing 1 [Homo sapiens]                49   5e-06
gi|64085252 hypothetical protein LOC145508 [Homo sapiens]              49   5e-06
gi|42794779 myosin 18A isoform b [Homo sapiens]                        49   7e-06
gi|28416946 myosin 18A isoform a [Homo sapiens]                        49   7e-06
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         47   3e-05
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         47   3e-05
gi|31542634 filamin A interacting protein 1 [Homo sapiens]             44   1e-04
gi|154354990 ankyrin repeat domain 26 [Homo sapiens]                   44   1e-04
gi|237858621 polyamine modulated factor 1 binding protein 1 isof...    44   2e-04
gi|237858619 polyamine modulated factor 1 binding protein 1 isof...    44   2e-04
gi|10864047 epidermal growth factor receptor pathway substrate 1...    43   3e-04
gi|219521893 coiled-coil transcriptional coactivator isoform 2 [...    43   4e-04
gi|4885583 Rho-associated, coiled-coil containing protein kinase...    42   5e-04
gi|31652238 cut-like homeobox 1 isoform c [Homo sapiens]               42   5e-04

>gi|20149560 syntaxin 4 [Homo sapiens]
          Length = 297

 Score =  570 bits (1468), Expect = e-163
 Identities = 297/297 (100%), Positives = 297/297 (100%)

Query: 1   MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQ 60
           MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQ
Sbjct: 1   MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQ 60

Query: 61  ELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNT 120
           ELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNT
Sbjct: 61  ELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNT 120

Query: 121 RMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSG 180
           RMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSG
Sbjct: 121 RMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSG 180

Query: 181 QSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINR 240
           QSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINR
Sbjct: 181 QSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINR 240

Query: 241 IEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG 297
           IEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG
Sbjct: 241 IEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG 297


>gi|16418379 syntaxin 1B [Homo sapiens]
          Length = 288

 Score =  245 bits (625), Expect = 4e-65
 Identities = 140/296 (47%), Positives = 196/296 (66%), Gaps = 11/296 (3%)

Query: 1   MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQ 60
           M+DRT ELR   DS DEE+      VVH          +EFF +V  IR  I KL   V+
Sbjct: 1   MKDRTQELRSAKDSDDEEE------VVHVDRDHFM---DEFFEQVEEIRGCIEKLSEDVE 51

Query: 61  ELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADE-NYNSVN 119
           +++KQ   ILA P P+E  KQEL++L  +IK+   ++R +LKAIE   E+ +  N +S +
Sbjct: 52  QVKKQHSAILAAPNPDEKTKQELEDLTADIKKTANKVRSKLKAIEQSIEQEEGLNRSSAD 111

Query: 120 TRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDS 179
            R+RKTQH  LS++FVE++ + N+ QS+YR++  +RI+RQL+IT     ++EELE ML+S
Sbjct: 112 LRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGR-TTTNEELEDMLES 170

Query: 180 GQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMIN 239
           G+  +F  +I  D+Q+T+QALNEI  RH+EI +LE SIRELHD+F  +A  VE QGEMI+
Sbjct: 171 GKLAIFTDDIKMDSQMTKQALNEIETRHNEIIKLETSIRELHDMFVDMAMLVESQGEMID 230

Query: 240 RIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTV 295
           RIE N+  S DYVER     K A++ Q KAR+KK++I IC  +  V+LA  IG T+
Sbjct: 231 RIEYNVEHSVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVVLGVVLASSIGGTL 286


>gi|37577287 syntaxin 2 isoform 1 [Homo sapiens]
          Length = 287

 Score =  236 bits (603), Expect = 1e-62
 Identities = 123/259 (47%), Positives = 186/259 (71%), Gaps = 4/259 (1%)

Query: 39  EEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIR 98
           ++FFH+V  IR +I K+   V+E++K    IL+ P PE  +K+EL++L  EIK+   +IR
Sbjct: 30  DDFFHQVEEIRNSIDKITQYVEEVKKNHSIILSAPNPEGKIKEELEDLNKEIKKTANKIR 89

Query: 99  LQLKAIEPQKEEADENYN--SVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERI 156
            +LKAIE Q  + DE+ N  SV+ R+R+TQH VLS++FVE + + N  Q+ +RE++  RI
Sbjct: 90  AKLKAIE-QSFDQDESGNRTSVDLRIRRTQHSVLSRKFVEAMAEYNEAQTLFRERSKGRI 148

Query: 157 RRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERS 216
           +RQL+IT     +D+ELE+ML+SG+  +F S+I+ D+Q+TRQALNEI +RH +I +LE S
Sbjct: 149 QRQLEITGR-TTTDDELEEMLESGKPSIFTSDIISDSQITRQALNEIESRHKDIMKLETS 207

Query: 217 IRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLI 276
           IRELH++F  +A  VE QGEMIN IE+N++++ DYVE  +E  K A++ Q KAR+K + I
Sbjct: 208 IRELHEMFMDMAMFVETQGEMINNIERNVMNATDYVEHAKEETKKAIKYQSKARRKLMFI 267

Query: 277 AICVSITVVLLAVIIGVTV 295
            ICV + +V+L +I+  T+
Sbjct: 268 IICVIVLLVILGIILATTL 286


>gi|4759182 syntaxin 1A (brain) [Homo sapiens]
          Length = 288

 Score =  236 bits (602), Expect = 2e-62
 Identities = 135/298 (45%), Positives = 195/298 (65%), Gaps = 14/298 (4%)

Query: 1   MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQ 60
           M+DRT ELR   DS D++D   VA+ V           +EFF +V  IR  I K+   V+
Sbjct: 1   MKDRTQELRTAKDSDDDDD---VAVTVDRDRFM-----DEFFEQVEEIRGFIDKIAENVE 52

Query: 61  ELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADE-NYNSVN 119
           E++++   ILA+P P+E  K+EL+ L  +IK+   ++R +LK+IE   E+ +  N +S +
Sbjct: 53  EVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSIEQEEGLNRSSAD 112

Query: 120 TRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDS 179
            R+RKTQH  LS++FVE++++ N+ QS+YRE+   RI+RQL+IT     S EELE ML+S
Sbjct: 113 LRIRKTQHSTLSRKFVEVMSEYNATQSDYRERCKGRIQRQLEITGRTTTS-EELEDMLES 171

Query: 180 GQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMIN 239
           G   +F S I+ D+ +++QAL+EI  RHSEI +LE SIRELHD+F  +A  VE QGEMI+
Sbjct: 172 GNPAIFASGIIMDSSISKQALSEIETRHSEIIKLENSIRELHDMFMDMAMLVESQGEMID 231

Query: 240 RIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG 297
           RIE N+  + DYVER     K A++ Q KAR+KK++I IC     V+L ++I  TV G
Sbjct: 232 RIEYNVEHAVDYVERAVSDTKKAVKYQSKARRKKIMIIIC----CVILGIVIASTVGG 285


>gi|37577162 syntaxin 2 isoform 2 [Homo sapiens]
          Length = 288

 Score =  233 bits (594), Expect = 2e-61
 Identities = 123/259 (47%), Positives = 186/259 (71%), Gaps = 4/259 (1%)

Query: 39  EEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIR 98
           ++FFH+V  IR +I K+   V+E++K    IL+ P PE  +K+EL++L  EIK+   +IR
Sbjct: 30  DDFFHQVEEIRNSIDKITQYVEEVKKNHSIILSAPNPEGKIKEELEDLNKEIKKTANKIR 89

Query: 99  LQLKAIEPQKEEADENYN--SVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERI 156
            +LKAIE Q  + DE+ N  SV+ R+R+TQH VLS++FVE + + N  Q+ +RE++  RI
Sbjct: 90  AKLKAIE-QSFDQDESGNRTSVDLRIRRTQHSVLSRKFVEAMAEYNEAQTLFRERSKGRI 148

Query: 157 RRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERS 216
           +RQL+IT     +D+ELE+ML+SG+  +F S+I+ D+Q+TRQALNEI +RH +I +LE S
Sbjct: 149 QRQLEITGR-TTTDDELEEMLESGKPSIFTSDIISDSQITRQALNEIESRHKDIMKLETS 207

Query: 217 IRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLI 276
           IRELH++F  +A  VE QGEMIN IE+N++++ DYVE  +E  K A++ Q KAR+KK +I
Sbjct: 208 IRELHEMFMDMAMFVETQGEMINNIERNVMNATDYVEHAKEETKKAIKYQSKARRKKWII 267

Query: 277 AICVSITVVLLAVIIGVTV 295
                + V ++A+IIG++V
Sbjct: 268 IAVSVVLVAIIALIIGLSV 286


>gi|4759184 syntaxin 3 [Homo sapiens]
          Length = 289

 Score =  213 bits (542), Expect = 2e-55
 Identities = 120/295 (40%), Positives = 194/295 (65%), Gaps = 9/295 (3%)

Query: 1   MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQ 60
           M+DR  +L+    + D+ D + V + +   TA +    +EFF ++   R  I K+   V+
Sbjct: 1   MKDRLEQLKAKQLTQDD-DTDAVEIAID-NTAFM----DEFFSEIEETRLNIDKISEHVE 54

Query: 61  ELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNT 120
           E +K    IL+ P+PE   K +L+ L  EIK+    +R +LK++E   EE DE  +S + 
Sbjct: 55  EAKKLYSIILSAPIPEPKTKDDLEQLTTEIKKRANNVRNKLKSMEKHIEE-DEVRSSADL 113

Query: 121 RMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSG 180
           R+RK+QH VLS++FVE++ K N  Q ++RE++  RI+RQL+IT     +DEELE+ML+SG
Sbjct: 114 RIRKSQHSVLSRKFVEVMTKYNEAQVDFRERSKGRIQRQLEITGK-KTTDEELEEMLESG 172

Query: 181 QSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINR 240
              +F S I+ D+Q+++QAL+EI  RH +I +LE SI+ELHD+F  +A  VE QGEM++ 
Sbjct: 173 NPAIFTSGII-DSQISKQALSEIEGRHKDIVRLESSIKELHDMFMDIAMLVENQGEMLDN 231

Query: 241 IEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTV 295
           IE N++ + D+VE+ ++  K A++ Q +ARKK ++I + V + + +LA+IIG++V
Sbjct: 232 IELNVMHTVDHVEKARDETKKAVKYQSQARKKLIIIIVLVVVLLGILALIIGLSV 286


>gi|33667038 syntaxin 11 [Homo sapiens]
          Length = 287

 Score =  118 bits (296), Expect = 5e-27
 Identities = 81/278 (29%), Positives = 139/278 (50%), Gaps = 16/278 (5%)

Query: 1   MRDRTHEL--------RQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTI 52
           M+DR  EL        +Q  D  DE D     +V            E  +  +R I+   
Sbjct: 1   MKDRLAELLDLSKQYDQQFPDGDDEFDSPHEDIVFETDHIL-----ESLYRDIRDIQDEN 55

Query: 53  VKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEAD 112
             L   V+ L KQ    L +     S+K++  ++   IK  G  I  +L+A++   E A+
Sbjct: 56  QLLVADVKRLGKQNARFLTSMRRLSSIKRDTNSIAKAIKARGEVIHCKLRAMKELSEAAE 115

Query: 113 ENY--NSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSD 170
             +  +S   R+ + Q+  L+  F   ++  N  + + R+    RI+RQL+I     VS 
Sbjct: 116 AQHGPHSAVARISRAQYNALTLTFQRAMHDYNQAEMKQRDNCKIRIQRQLEIMGKE-VSG 174

Query: 171 EELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATE 230
           +++E M + G+ +VF  N+L D +  R ALNEI +RH E+ +LE  IR++H++F  +A  
Sbjct: 175 DQIEDMFEQGKWDVFSENLLADVKGARAALNEIESRHRELLRLESRIRDVHELFLQMAVL 234

Query: 231 VEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKK 268
           VE Q + +N IE N+  + DY  + +  V+ A++ ++K
Sbjct: 235 VEKQADTLNVIELNVQKTVDYTGQAKAQVRKAVQYEEK 272


>gi|49258196 syntaxin 19 [Homo sapiens]
          Length = 294

 Score =  117 bits (294), Expect = 9e-27
 Identities = 84/283 (29%), Positives = 145/283 (51%), Gaps = 7/283 (2%)

Query: 1   MRDRTHELRQGDDS--SDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNK 58
           ++ RT E+    DS  S  E +E+   +            E   H+++ ++++I  L + 
Sbjct: 8   LKQRTKEIELSRDSHVSTTETEEQGVFLQQAVIYEREPVAERHLHEIQKLQESINNLADN 67

Query: 59  VQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAI--EPQKEEADENYN 116
           VQ+  +QQ +++A+      +K+E   +  EIK     I   L  +  E +K E +   +
Sbjct: 68  VQKFGQQQKSLVASMRRFSLLKRE-STITKEIKIQAEYINRSLNDLVKEVKKSEVENGPS 126

Query: 117 SVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQM 176
           SV TR+ K+QH  + + F +++   N   +  +EK    I RQL++    M S+E++  M
Sbjct: 127 SVVTRILKSQHAAMFRHFQQIMFIYNDTIAAKQEKCKTFILRQLEVAGKEM-SEEDVNDM 185

Query: 177 LDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGE 236
           L  G+ EVF  ++L +  +T+  L+EI  RH E+  LE  I++L D+F  ++  VE QGE
Sbjct: 186 LHQGKWEVFNESLLTEINITKAQLSEIEQRHKELVNLENQIKDLRDLFIQISLLVEEQGE 245

Query: 237 MINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAIC 279
            IN IE  + S+ +YV   +E    A++  KK    +VL   C
Sbjct: 246 SINNIEMTVNSTKEYVNNTKEKFGLAVK-YKKRNPCRVLCCWC 287


>gi|28933465 syntaxin 12 [Homo sapiens]
          Length = 276

 Score = 88.6 bits (218), Expect = 6e-18
 Identities = 69/266 (25%), Positives = 125/266 (46%), Gaps = 9/266 (3%)

Query: 28  HPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLR 87
           +PG +  G    +F   ++T    I ++     ++ K  ++ L T      +++ LQ L+
Sbjct: 11  NPGPS--GPQLRDFSSIIQTCSGNIQRISQATAQI-KNLMSQLGTKQDSSKLQENLQQLQ 67

Query: 88  DEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSE 147
               QL +E    LK +           ++   R ++ Q   L   F   +N   ++Q  
Sbjct: 68  HSTNQLAKETNELLKELG----SLPLPLSTSEQRQQRLQKERLMNDFSAALNNFQAVQRR 123

Query: 148 YREKNVERIRRQLKITNAGMVSDEELEQML--DSGQSEVFVSNILKDTQVTRQALNEISA 205
             EK  E I R    +       +  EQ++  DS +    + +   +  +T Q L  I  
Sbjct: 124 VSEKEKESIARARAGSRLSAEERQREEQLVSFDSHEEWNQMQSQEDEVAITEQDLELIKE 183

Query: 206 RHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALEN 265
           R + I+QLE  I +++ IF  LA  +  QG++I+ IE N+ SS  +VER  E ++ A   
Sbjct: 184 RETAIRQLEADILDVNQIFKDLAMMIHDQGDLIDSIEANVESSEVHVERATEQLQRAAYY 243

Query: 266 QKKARKKKVLIAICVSITVVLLAVII 291
           QKK+RKK  ++ + +S+ +++L +II
Sbjct: 244 QKKSRKKMCILVLVLSVIILILGLII 269


>gi|170932494 syntaxin 7 [Homo sapiens]
          Length = 261

 Score = 85.5 bits (210), Expect = 5e-17
 Identities = 64/264 (24%), Positives = 122/264 (46%), Gaps = 14/264 (5%)

Query: 31  TARLGSPDEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEI 90
           T  +G    +   ++ +  Q I +   ++Q    Q    L TP     ++Q+LQ  +   
Sbjct: 4   TPGVGGDPAQLAQRISSNIQKITQCSVEIQRTLNQ----LGTPQDSPELRQQLQQKQQYT 59

Query: 91  KQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYRE 150
            QL +E    +K          E       R RK Q   L  +F   +     +Q +  E
Sbjct: 60  NQLAKETDKYIKEFGSLPTTPSEQ------RQRKIQKDRLVAEFTTSLTNFQKVQRQAAE 113

Query: 151 KNVE---RIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARH 207
           +  E   R+R   +++ +    D   E+ L S +S+      ++D ++T   L  I  R 
Sbjct: 114 REKEFVARVRASSRVSGS-FPEDSSKERNLVSWESQTQPQVQVQDEEITEDDLRLIHERE 172

Query: 208 SEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQK 267
           S I+QLE  I ++++IF  L   +  QG++I+ IE N+ ++  +V++  + +  A + Q+
Sbjct: 173 SSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVENAEVHVQQANQQLSRAADYQR 232

Query: 268 KARKKKVLIAICVSITVVLLAVII 291
           K+RK   +I + + I V ++++II
Sbjct: 233 KSRKTLCIIILILVIGVAIISLII 256


>gi|198041692 syntaxin 16 isoform d [Homo sapiens]
          Length = 308

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 77/306 (25%), Positives = 142/306 (46%), Gaps = 26/306 (8%)

Query: 1   MRDRTHELRQ--GDDSSDEEDKERVALV----VHPGTARLG---SPDEEFFHKVRTIRQT 51
           +R+ + + RQ   +   DE   +R+ALV    + P  A +G    P  ++   V  I+  
Sbjct: 13  LRNNSIQNRQLLAEQELDELADDRMALVSGISLDPEAA-IGVTKRPPPKWVDGVDEIQYD 71

Query: 52  IVKLGNKVQELEKQQVTILATPLPEESMKQE--LQNLRDEIKQLGREIRLQLKAIEPQKE 109
           + ++  K++EL       L  P  ++S ++E  ++    EI QL    +  ++A+  +  
Sbjct: 72  VGRIKQKMKELASLHDKHLNRPTLDDSSEEEHAIEITTQEITQLFHRCQRAVQALPSRAR 131

Query: 110 EADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEY--REKNVERIRRQLKITNAGM 167
              E       R+       L+Q   EL       QS Y  R KN E   +    T+  +
Sbjct: 132 ACSEQEG----RLLGNVVASLAQALQELSTSFRHAQSGYLKRMKNREERSQHFFDTSVPL 187

Query: 168 VSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFL 227
           + D +   +   G +E  +  + ++T +  +       R  EI+Q+ +SI +L++IF  L
Sbjct: 188 MDDGDDNTLYHRGFTEDQLVLVEQNTLMVEE-------REREIRQIVQSISDLNEIFRDL 240

Query: 228 ATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLL 287
              +  QG +++RI+ N+  S    E G + +  A + QKK RK  V++ + V I +VL+
Sbjct: 241 GAMIVEQGTVLDRIDYNVEQSCIKTEDGLKQLHKAEQYQKKNRKMLVILILFV-IIIVLI 299

Query: 288 AVIIGV 293
            V++GV
Sbjct: 300 VVLVGV 305


>gi|47778943 syntaxin 16 isoform a [Homo sapiens]
          Length = 325

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 65/261 (24%), Positives = 121/261 (46%), Gaps = 16/261 (6%)

Query: 37  PDEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQE--LQNLRDEIKQLG 94
           P  ++   V  I+  + ++  K++EL       L  P  ++S ++E  ++    EI QL 
Sbjct: 74  PPPKWVDGVDEIQYDVGRIKQKMKELASLHDKHLNRPTLDDSSEEEHAIEITTQEITQLF 133

Query: 95  REIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEY--REKN 152
              +  ++A+  +     E       R+       L+Q   EL       QS Y  R KN
Sbjct: 134 HRCQRAVQALPSRARACSEQEG----RLLGNVVASLAQALQELSTSFRHAQSGYLKRMKN 189

Query: 153 VERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQ 212
            E   +    T+  ++ D +   +   G +E  +  + ++T +  +       R  EI+Q
Sbjct: 190 REERSQHFFDTSVPLMDDGDDNTLYHRGFTEDQLVLVEQNTLMVEE-------REREIRQ 242

Query: 213 LERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKK 272
           + +SI +L++IF  L   +  QG +++RI+ N+  S    E G + +  A + QKK RK 
Sbjct: 243 IVQSISDLNEIFRDLGAMIVEQGTVLDRIDYNVEQSCIKTEDGLKQLHKAEQYQKKNRKM 302

Query: 273 KVLIAICVSITVVLLAVIIGV 293
            V++ + V I +VL+ V++GV
Sbjct: 303 LVILILFV-IIIVLIVVLVGV 322


>gi|198041688 syntaxin 16 isoform c [Homo sapiens]
          Length = 321

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 65/261 (24%), Positives = 121/261 (46%), Gaps = 16/261 (6%)

Query: 37  PDEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQE--LQNLRDEIKQLG 94
           P  ++   V  I+  + ++  K++EL       L  P  ++S ++E  ++    EI QL 
Sbjct: 70  PPPKWVDGVDEIQYDVGRIKQKMKELASLHDKHLNRPTLDDSSEEEHAIEITTQEITQLF 129

Query: 95  REIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEY--REKN 152
              +  ++A+  +     E       R+       L+Q   EL       QS Y  R KN
Sbjct: 130 HRCQRAVQALPSRARACSEQEG----RLLGNVVASLAQALQELSTSFRHAQSGYLKRMKN 185

Query: 153 VERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQ 212
            E   +    T+  ++ D +   +   G +E  +  + ++T +  +       R  EI+Q
Sbjct: 186 REERSQHFFDTSVPLMDDGDDNTLYHRGFTEDQLVLVEQNTLMVEE-------REREIRQ 238

Query: 213 LERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKK 272
           + +SI +L++IF  L   +  QG +++RI+ N+  S    E G + +  A + QKK RK 
Sbjct: 239 IVQSISDLNEIFRDLGAMIVEQGTVLDRIDYNVEQSCIKTEDGLKQLHKAEQYQKKNRKM 298

Query: 273 KVLIAICVSITVVLLAVIIGV 293
            V++ + V I +VL+ V++GV
Sbjct: 299 LVILILFV-IIIVLIVVLVGV 318


>gi|34447229 syntaxin 16 isoform b [Homo sapiens]
          Length = 304

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 65/261 (24%), Positives = 121/261 (46%), Gaps = 16/261 (6%)

Query: 37  PDEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQE--LQNLRDEIKQLG 94
           P  ++   V  I+  + ++  K++EL       L  P  ++S ++E  ++    EI QL 
Sbjct: 53  PPPKWVDGVDEIQYDVGRIKQKMKELASLHDKHLNRPTLDDSSEEEHAIEITTQEITQLF 112

Query: 95  REIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEY--REKN 152
              +  ++A+  +     E       R+       L+Q   EL       QS Y  R KN
Sbjct: 113 HRCQRAVQALPSRARACSEQEG----RLLGNVVASLAQALQELSTSFRHAQSGYLKRMKN 168

Query: 153 VERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQ 212
            E   +    T+  ++ D +   +   G +E  +  + ++T +  +       R  EI+Q
Sbjct: 169 REERSQHFFDTSVPLMDDGDDNTLYHRGFTEDQLVLVEQNTLMVEE-------REREIRQ 221

Query: 213 LERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKK 272
           + +SI +L++IF  L   +  QG +++RI+ N+  S    E G + +  A + QKK RK 
Sbjct: 222 IVQSISDLNEIFRDLGAMIVEQGTVLDRIDYNVEQSCIKTEDGLKQLHKAEQYQKKNRKM 281

Query: 273 KVLIAICVSITVVLLAVIIGV 293
            V++ + V I +VL+ V++GV
Sbjct: 282 LVILILFV-IIIVLIVVLVGV 301


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 51.6 bits (122), Expect = 8e-07
 Identities = 65/280 (23%), Positives = 126/280 (45%), Gaps = 37/280 (13%)

Query: 2    RDRTHELRQGDDSSDEEDK---ERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNK 58
            R+R   L++  +    + K   E +AL+    T  L   +EE    V T+R  I +L  K
Sbjct: 1399 RERAQALQEQGELKVAQGKALQENLALL----TQTLAEREEE----VETLRGQIQEL-EK 1449

Query: 59   VQELEKQQVTILATPLPEESMK--------QELQNLRDEIKQLGREIRLQLKAIEPQKEE 110
             +E++K  + +L+  L + + +        QEL+  R  ++ L   ++ + + +  Q+E+
Sbjct: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509

Query: 111  ADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSD 170
              E       + R+TQ  VL  Q +EL  K   ++S+     V+ +++QL       +  
Sbjct: 1510 IRE-----LEKDRETQRNVLEHQLLELEKKDQMIESQ--RGQVQDLKKQLVTLECLALEL 1562

Query: 171  EELEQMLDSGQSEVFVSNILKDTQVTRQALN----EISARHSEIQQLERSIRELHDIFTF 226
            EE    ++  Q  +      ++TQ  R AL     ++  R  E+Q     I +L    T 
Sbjct: 1563 EENHHKMECQQKLIKELEGQRETQ--RVALTHLTLDLEERSQELQAQSSQIHDLESHSTV 1620

Query: 227  LATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQ 266
            LA E++ + + +    + I    + ++R +EH+   LE +
Sbjct: 1621 LARELQERDQEVKSQREQI----EELQRQKEHLTQDLERR 1656



 Score = 45.8 bits (107), Expect = 5e-05
 Identities = 41/218 (18%), Positives = 95/218 (43%), Gaps = 9/218 (4%)

Query: 58   KVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNS 117
            ++QELEK +  +   P+  +  +Q+L   R++I++L ++   Q   +E Q  E ++    
Sbjct: 1478 QIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQM 1537

Query: 118  VNTRMRKTQH--------GVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVS 169
            + ++  + Q           L+ +  E  +K    Q   +E   +R  +++ +T+  +  
Sbjct: 1538 IESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDL 1597

Query: 170  DEELEQM-LDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLA 228
            +E  +++   S Q     S+     +  ++   E+ ++  +I++L+R    L        
Sbjct: 1598 EERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRD 1657

Query: 229  TEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQ 266
             E+ +Q E I  +E         +E   E +K +L  +
Sbjct: 1658 QELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRER 1695



 Score = 38.9 bits (89), Expect = 0.006
 Identities = 47/236 (19%), Positives = 108/236 (45%), Gaps = 19/236 (8%)

Query: 38   DEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEES----MKQELQNLRDEIKQL 93
            ++E    + T+ QT  +L +  Q+LE+ +  +    L E+     ++ +LQ  + E+K+ 
Sbjct: 924  EKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEA 983

Query: 94   GREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYRE-KN 152
             R+ R  L A++ +     ++   +  ++   +  +++Q   + + +   +Q + RE + 
Sbjct: 984  ARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVE-QEVQEKLRETQE 1042

Query: 153  VERIRRQLKITNAGM-VSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQ 211
              RI+++L+   A + +S  E EQ L           +L++    RQ   E+SA   ++Q
Sbjct: 1043 YNRIQKELEREKASLTLSLMEKEQRL----------LVLQEADSIRQ--QELSALRQDMQ 1090

Query: 212  QLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQK 267
            + +   +EL      L  EV+ +       E  +L   +     ++ ++ +L  Q+
Sbjct: 1091 EAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQE 1146



 Score = 38.1 bits (87), Expect = 0.009
 Identities = 51/233 (21%), Positives = 97/233 (41%), Gaps = 42/233 (18%)

Query: 49   RQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRL---QLKAIE 105
            +QT   L ++VQ+LE++   +  T   +  +  ELQ+L+ ++ Q   E      +  ++E
Sbjct: 1256 QQTRDVLRDQVQKLEER---LTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLE 1312

Query: 106  PQKEEADENYNSVNTRMRKTQ-HGVLSQQFVELIN--------------------KCNSM 144
             +  E  E   S+ +R+R+ +   + +Q   EL+                     +  + 
Sbjct: 1313 SELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQAS 1372

Query: 145  QSEYREKNVERIRRQLKITNAGMVSDEELEQMLDS------GQSEVFVSNILKDTQVTRQ 198
             +   E+++   R  LK+ N  + S+ E  Q L         Q +    N+   TQ   +
Sbjct: 1373 AAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAE 1432

Query: 199  ALNEISARHSEIQQLERSIRELHDIFTFLAT--------EVEMQGEMINRIEK 243
               E+     +IQ+LE+  RE+      L +        EV++Q E I  +EK
Sbjct: 1433 REEEVETLRGQIQELEKQ-REMQKAALELLSLDLKKRNQEVDLQQEQIQELEK 1484



 Score = 33.5 bits (75), Expect = 0.23
 Identities = 39/180 (21%), Positives = 75/180 (41%), Gaps = 21/180 (11%)

Query: 46  RTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQ------------- 92
           + +RQ + KL  +   L  Q V +          ++ LQ  R+E++Q             
Sbjct: 431 KALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLR 490

Query: 93  -LGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVL------SQQFVELINKCNSMQ 145
            +  E++LQ  + + QKEE  E  +       + Q  ++      S+   ELI    +++
Sbjct: 491 RVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALE 550

Query: 146 SEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISA 205
           S + E  + R + Q ++T A   +++ + ++  S  +       L+   V   ALNE  A
Sbjct: 551 SSHLEGELLR-QEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALA 609



 Score = 33.1 bits (74), Expect = 0.30
 Identities = 55/230 (23%), Positives = 101/230 (43%), Gaps = 40/230 (17%)

Query: 50   QTIVKLGNKVQELEKQQVTI--LATPLPEESMKQEL-QNLRDEIKQLGREIRLQLKAIEP 106
            Q I     +VQ+L+KQ VT+  LA  L E   K E  Q L  E++      R+ L  +  
Sbjct: 1536 QMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTL 1595

Query: 107  QKEEADENYNSVNTRMR--KTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITN 164
              EE  +   + ++++   ++   VL+++  E   +  S + +     +E ++RQ     
Sbjct: 1596 DLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQ-----IEELQRQ----- 1645

Query: 165  AGMVSDEELEQMLDSGQSEVFVS----NILKDTQVTRQALNEISARHSEIQQLERSIREL 220
                  E L Q L+    E+ +      +L+D Q TRQ          +++Q++ S+RE 
Sbjct: 1646 -----KEHLTQDLERRDQELMLQKERIQVLED-QRTRQT----KILEEDLEQIKLSLRE- 1694

Query: 221  HDIFTFLATEVEMQGEMI-NRIEKNILSSADYVERGQ-EHVKTALENQKK 268
                     E+  Q +++  R E+         +RG  EH+K  L +++K
Sbjct: 1695 ------RGRELTTQRQLMQERAEEG--KGPSKAQRGSLEHMKLILRDKEK 1736



 Score = 32.3 bits (72), Expect = 0.52
 Identities = 48/189 (25%), Positives = 82/189 (43%), Gaps = 28/189 (14%)

Query: 34   LGSPDEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNL-----RD 88
            L   DEE  H+               QE E+     LA  + +E+M QE QNL      +
Sbjct: 2044 LAQRDEELRHQ---------------QEREQLLEKSLAQRV-QENMIQEKQNLGQEREEE 2087

Query: 89   EIKQLGREIR-LQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSE 147
            EI+ L + +R LQL   + ++E  +         +    H   +    E   K +S++  
Sbjct: 2088 EIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPR 2147

Query: 148  YREKNVERIRRQLKITNAGMVSDEELEQ--MLDSGQSEVFVSNILKDTQVTRQALNEISA 205
              ++ +ER++  L+ T A  +   E  Q   L   Q++  VS+ L++  +  QA   +  
Sbjct: 2148 L-QRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSS-LQEVAMFLQA--SVLE 2203

Query: 206  RHSEIQQLE 214
            R SE Q+L+
Sbjct: 2204 RDSEQQRLQ 2212


>gi|112420968 coiled-coil domain containing 158 [Homo sapiens]
          Length = 1113

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 61/258 (23%), Positives = 113/258 (43%), Gaps = 24/258 (9%)

Query: 17  EEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPE 76
           E  KE +  VV   TA+  + +       RTI      L  K + +E     I       
Sbjct: 471 ESTKEMLRKVVEELTAKKMTLESS----ERTISDLTTSLQEKERAIEATNAEITKLRSRV 526

Query: 77  ESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKT-----QH---- 127
           +   QELQ+L++E   L R ++ + +A++ Q  E D+    +  ++        QH    
Sbjct: 527 DLKLQELQHLKNEGDHL-RNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTA 585

Query: 128 GVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITN-AGMVSDEELE--QMLDSGQSEV 184
           G +  +  +L  + N  + E +E  + + ++  KI      VSD ELE  +++++G   +
Sbjct: 586 GAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERL 645

Query: 185 FVSNILKDTQVTR-QALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEK 243
                +KD +  R Q LNE+    SE+  L      L   F   + E+EM     N+++ 
Sbjct: 646 ---RAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEM---TTNKLKM 699

Query: 244 NILSSADYVERGQEHVKT 261
            + S+   +E+ +  +K+
Sbjct: 700 QLKSAQSELEQTRNTLKS 717



 Score = 36.6 bits (83), Expect = 0.027
 Identities = 50/227 (22%), Positives = 97/227 (42%), Gaps = 31/227 (13%)

Query: 52  IVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEA 111
           I +L  +V +LE ++V              +L N   E          +L+A++  K+E 
Sbjct: 620 IRELEARVSDLELEKV--------------KLVNAGSE----------RLRAVKDIKQER 655

Query: 112 DENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDE 171
           D+  N V T   +++   LS+++ E++ +    +SE  E    +++ QLK   + +    
Sbjct: 656 DQLLNEVKT--SRSELNNLSEEY-EVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTR 712

Query: 172 ELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEV 231
              + ++          +    Q+T +   +I A  S+IQ LE ++   +    FL  E 
Sbjct: 713 NTLKSMEGSDGHAMKVAMGMQKQITAKR-GQIDALQSKIQFLEEAMTNANKEKHFLKEEK 771

Query: 232 EMQGEMINRI--EKNILSSADYVERGQE-HVKTALENQKKARKKKVL 275
               + ++ +  EKN ++    V R QE  +K  + N + A  K  L
Sbjct: 772 SKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASL 818



 Score = 34.7 bits (78), Expect = 0.10
 Identities = 36/178 (20%), Positives = 83/178 (46%), Gaps = 20/178 (11%)

Query: 50  QTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKE 109
           +++ K+ +   +LE  +  +        + K  L++    I  L   ++ + +AIE    
Sbjct: 458 ESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNA 517

Query: 110 EADENYNSVNTRMRKTQHGVLSQQFVELIN---KCNSMQSEYREKN--VERIRRQL---- 160
           E  +  + V+ ++++ QH  L  +   L N   +C +++ +  EK+  +E +R+Q+    
Sbjct: 518 EITKLRSRVDLKLQELQH--LKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMT 575

Query: 161 -------KITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQ 211
                  +   A  V   +LE+ ++  + E+    ILKD +  +  + E+ AR S+++
Sbjct: 576 QLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAK--IRELEARVSDLE 631



 Score = 28.5 bits (62), Expect = 7.4
 Identities = 24/88 (27%), Positives = 49/88 (55%), Gaps = 10/88 (11%)

Query: 48  IRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQ 107
           +RQ+++ L  K+QE++ ++   +A     ES  QE  +LR++++    E    L+A +  
Sbjct: 108 LRQSVIDLQTKLQEMQMER-DAMADIRRRESQSQE--DLRNQLQNTVHE----LEAAKCL 160

Query: 108 KEEADENYNSVNTRMRK---TQHGVLSQ 132
           KE+  ++ N+   ++RK   +  GVL +
Sbjct: 161 KEDMLKDSNTQIEQLRKMMLSHEGVLQE 188


>gi|223972648 t-SNARE domain containing 1 [Homo sapiens]
          Length = 513

 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 51/255 (20%), Positives = 109/255 (42%), Gaps = 21/255 (8%)

Query: 52  IVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEA 111
           + ++ + V  LE+  +  L TP   + ++  L   + E     + I     +++   E  
Sbjct: 268 VFRINSSVTSLERS-LQSLGTPSDTQELRDSLHTAQQETN---KTIAASASSVKQMAELL 323

Query: 112 DENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERI-------RRQLKITN 164
             +      +  + Q   L  Q  + I     +Q +  EK+   +       ++  +   
Sbjct: 324 RSSCPQERLQQERPQLDRLKTQLSDAIQCYGVVQKKIAEKSRALLPMAQRGSKQSPQAPF 383

Query: 165 AGMVSDEELEQMLDS---GQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELH 221
           A +  DE++    D+   GQ +  + +I      T + L  I  R   I Q+E ++ +++
Sbjct: 384 AELADDEKVFNGSDNMWQGQEQALLPDI------TEEDLEAIRLREEAILQMESNLLDVN 437

Query: 222 DIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVS 281
            I   LA+ V  QGE ++ IE ++ +++ + E  ++ +  A  +Q +  K K    +   
Sbjct: 438 QIIKDLASMVSEQGEAVDSIEASLEAASSHAEAARQLLAGASRHQLQRHKIKCCF-LSAG 496

Query: 282 ITVVLLAVIIGVTVV 296
           +T +L+ +II  T V
Sbjct: 497 VTALLVIIIIIATSV 511


>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
          Length = 1094

 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 53/245 (21%), Positives = 112/245 (45%), Gaps = 25/245 (10%)

Query: 49  RQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIK----QLGREIRLQLK-A 103
           ++ + +L  K+ E +KQ+V         + +++E++  R+ ++    QLG  + LQL+ A
Sbjct: 197 KRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGL-MSLQLQEA 255

Query: 104 IEPQKEEADENYNSVNTRMRKTQHGVLS-QQFVELINKCNSMQSEYREK---NVERIRRQ 159
           ++ Q+ +ADE+  ++  ++R+T+      +Q +EL  +  +     RE     VE +R Q
Sbjct: 256 LKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQ 315

Query: 160 LKITNA---------GMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEI------S 204
           L                +S ++     + G+   F   + ++ Q   + ++++      S
Sbjct: 316 LTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFS 375

Query: 205 ARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALE 264
           A  SE+++++R +         LA++VE     +   EK  L   D ++  Q H  T   
Sbjct: 376 AMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEA 435

Query: 265 NQKKA 269
            +K A
Sbjct: 436 ERKHA 440



 Score = 36.6 bits (83), Expect = 0.027
 Identities = 49/215 (22%), Positives = 98/215 (45%), Gaps = 28/215 (13%)

Query: 77  ESMKQELQN-LRDEIKQLGR--EIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQ 133
           E++ +EL+N  + +++ L R  EI+      E +++ AD   + + TR  +       + 
Sbjct: 403 ENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISEL-TRHAEDATKQAERY 461

Query: 134 FVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSD-----EELEQMLDSGQSEVFVSN 188
             EL       QSE  ++  E+ R  LK+     +       ++LE+ L+  QSE     
Sbjct: 462 LSEL------QQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEK-QSETVDEL 514

Query: 189 ILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLA---TEVEMQGEMINRI---- 241
             K+ Q+ ++     +  ++ +QQ+E   +EL+D+ T  A    E+  + E +  I    
Sbjct: 515 TGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQ 574

Query: 242 ---EKNILSSADYVERGQEHVK--TALENQKKARK 271
              E  + +S D + R +  +K  + +++Q K  K
Sbjct: 575 ADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEK 609


>gi|42794779 myosin 18A isoform b [Homo sapiens]
          Length = 2039

 Score = 48.5 bits (114), Expect = 7e-06
 Identities = 53/233 (22%), Positives = 105/233 (45%), Gaps = 45/233 (19%)

Query: 49   RQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLR---DEIKQLGREIRLQLKAIE 105
            ++ I +L N   +LE+ + T  A     ++M+ E+++L    D+I +    +  QL  ++
Sbjct: 1682 KREIAQLKN---QLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQ 1738

Query: 106  PQKEEA----DENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLK 161
             +K E     +E+   +N  M+K  H     Q    + + N +Q++  E N E+      
Sbjct: 1739 REKNEIQNRLEEDQEDMNELMKK--HKAAVAQASRDLAQINDLQAQLEEANKEK------ 1790

Query: 162  ITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELH 221
                     +EL++ L + QS+V             + L +     S + + E  IREL 
Sbjct: 1791 ---------QELQEKLQALQSQV-------------EFLEQSMVDKSLVSRQEAKIRELE 1828

Query: 222  DIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKV 274
                F  T+V+    + +R+++N+    +  ER Q   + A EN++K + K++
Sbjct: 1829 TRLEFERTQVKRLESLASRLKENMEKLTE--ERDQ---RIAAENREKEQNKRL 1876


>gi|28416946 myosin 18A isoform a [Homo sapiens]
          Length = 2054

 Score = 48.5 bits (114), Expect = 7e-06
 Identities = 53/233 (22%), Positives = 105/233 (45%), Gaps = 45/233 (19%)

Query: 49   RQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLR---DEIKQLGREIRLQLKAIE 105
            ++ I +L N   +LE+ + T  A     ++M+ E+++L    D+I +    +  QL  ++
Sbjct: 1682 KREIAQLKN---QLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQ 1738

Query: 106  PQKEEA----DENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLK 161
             +K E     +E+   +N  M+K  H     Q    + + N +Q++  E N E+      
Sbjct: 1739 REKNEIQNRLEEDQEDMNELMKK--HKAAVAQASRDLAQINDLQAQLEEANKEK------ 1790

Query: 162  ITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELH 221
                     +EL++ L + QS+V             + L +     S + + E  IREL 
Sbjct: 1791 ---------QELQEKLQALQSQV-------------EFLEQSMVDKSLVSRQEAKIRELE 1828

Query: 222  DIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKV 274
                F  T+V+    + +R+++N+    +  ER Q   + A EN++K + K++
Sbjct: 1829 TRLEFERTQVKRLESLASRLKENMEKLTE--ERDQ---RIAAENREKEQNKRL 1876


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 58/277 (20%), Positives = 126/277 (45%), Gaps = 31/277 (11%)

Query: 10  QGDDSSDEEDKERVALVVHPGTA---RLGSPDEEFF---HKVRTIRQTIVKLGNKVQELE 63
           Q  +S  E+ KE + L++    A   +L    EE      +++  RQTI +  +K+ E  
Sbjct: 503 QDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAH 562

Query: 64  KQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMR 123
           K   T+       E +K E+ +  +  K+L  +   ++   + + E  ++  N+V  RM 
Sbjct: 563 KSLSTV-------EDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMA 615

Query: 124 KTQHGVLSQQFVELINKCNSMQSEYREK-------NVERIRRQLKITNAGMVSDEELEQM 176
           ++Q   L +   +L+       S+ +E        N+E+++      N G+   ++++ +
Sbjct: 616 ESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLK-----DNLGIHYKQQIDGL 670

Query: 177 LDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERS-IRELHDIFTFLATEVEMQG 235
            +    ++      KD  +T+Q  N++    S+++ L++S +    +  T    E++ + 
Sbjct: 671 QNEMSQKIETMQFEKDNLITKQ--NQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEI 728

Query: 236 EMINRIEKNILSSADYVERGQEHVKT-ALENQKKARK 271
           E++ + EK   +    V+  Q  +KT  LE Q K ++
Sbjct: 729 EILRQEEKEKGTLEQEVQELQ--LKTELLEKQMKEKE 763



 Score = 41.6 bits (96), Expect = 8e-04
 Identities = 53/278 (19%), Positives = 110/278 (39%), Gaps = 57/278 (20%)

Query: 39   EEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESM------------------- 79
            E+   +VR + Q ++   +  Q++E ++        PE S+                   
Sbjct: 2147 EKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEIT 2206

Query: 80   ---------KQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRK------ 124
                     ++EL+N  +E++QL  ++ +Q K    + +E ++        M K      
Sbjct: 2207 NLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIK 2266

Query: 125  --------TQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQM 176
                     QH VL  +F ++I +   ++ +   + V ++++QLKIT    V +E+ E +
Sbjct: 2267 ESDAMSTQDQH-VLFGKFAQIIQE-KEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELI 2324

Query: 177  LDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGE 236
             D    E  +  ++ D +  ++       R  EI+QL   I +L      +  +  M   
Sbjct: 2325 RD---LETQIECLMSDQECVKR------NREEEIEQLNEVIEKLQQELANIGQKTSMNAH 2375

Query: 237  MINRIEKNILSSADYVERGQEHVKTALENQKKARKKKV 274
             ++    ++    D V       K ALE Q +   +++
Sbjct: 2376 SLSEEADSLKHQLDVVIA----EKLALEQQVETANEEM 2409



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 70/288 (24%), Positives = 125/288 (43%), Gaps = 55/288 (19%)

Query: 21   ERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQEL-----EKQQVTILATPLP 75
            E++AL     TA     +EE       +++T  K+    QEL     E++ V  + + +P
Sbjct: 2394 EKLALEQQVETA-----NEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS-IP 2447

Query: 76   EESMKQELQNLRDEIKQLGREIRLQ---LKAIEPQ------KEEADENYNSVNTRMRKTQ 126
            E S+   + +L  +  +L  E+ L    LK++E Q      +E    +  ++ TR+ + +
Sbjct: 2448 ENSVNVAIDHLSKDKPEL--EVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLE 2505

Query: 127  HGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITN----------AGMVSDEELEQM 176
              V S + +EL      ++    +   E    Q KI N          A +VS  +LE +
Sbjct: 2506 STV-SAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAV 2564

Query: 177  LDSGQ---------SEVFVSNILKDTQVTRQAL-NEISARHSEIQQLERSIRELHDIFTF 226
             +  +         SE   +NI    Q+    L ++ISA    I +LE  + E+H     
Sbjct: 2565 QEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMH----- 2619

Query: 227  LATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALE-NQKKARKKK 273
              T + ++ E +   EKN+L      E+    ++  LE N+KK R+K+
Sbjct: 2620 --TSLILEKEQVEIAEKNVLEK----EKKLLELQKLLEGNEKKQREKE 2661



 Score = 37.7 bits (86), Expect = 0.012
 Identities = 67/282 (23%), Positives = 122/282 (43%), Gaps = 70/282 (24%)

Query: 48   IRQTIVKLGNKVQELEKQQVTILAT----PLPEESMKQEL----QNLRDEIKQLGRE--- 96
            + Q ++   N++QELE +Q  I          +E+MK E     Q L  E ++L +E   
Sbjct: 1948 LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLE 2007

Query: 97   -----------IRLQLKAIEPQKEEADENYNSV----NTRMR--KTQHGVLSQQFVELIN 139
                       ++ Q+KA+E   EE    +  +    NT +   + Q+  L +Q +E + 
Sbjct: 2008 VQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQ-LEKMR 2066

Query: 140  KCNSMQSEYRE-------KNVERIRRQLKITNAGMVSDE----ELEQMLD--SGQSEVFV 186
            K    Q+  RE       + ++++ +QLK+        E    E+EQ+ +    +++   
Sbjct: 2067 KFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCS 2126

Query: 187  SNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIF-----TF--------------- 226
              +L   Q+ R    +I  R+ EI++LE  +REL         TF               
Sbjct: 2127 ELLLSKEQLQR----DIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK 2182

Query: 227  --LATEVEMQGE--MINRIEKNILSSADYVERGQEHVKTALE 264
              L+ EV++Q E   I+R EK I +  + +E+ +E ++   E
Sbjct: 2183 PELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNE 2224



 Score = 33.9 bits (76), Expect = 0.18
 Identities = 34/160 (21%), Positives = 73/160 (45%), Gaps = 12/160 (7%)

Query: 77  ESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVE 136
           E +KQ+   L +EI++         K  E   +E  E Y  +  +++       ++Q +E
Sbjct: 830 EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACL-LKVKDDLEDSKNKQELE 888

Query: 137 LINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEE---LEQMLDSGQ-SEVFVSNILKD 192
             +K  ++  E   + +     ++K      V DE+   + + L+ G+  E   + +++ 
Sbjct: 889 YKSKLKALNEELHLQRINPTTVKMK----SSVFDEDKTFVAETLEMGEVVEKDTTELMEK 944

Query: 193 TQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVE 232
            +VT++   E+S R S+   L   +++ H   +FL  EV+
Sbjct: 945 LEVTKREKLELSQRLSD---LSEQLKQKHGEISFLNEEVK 981



 Score = 31.6 bits (70), Expect = 0.88
 Identities = 49/264 (18%), Positives = 115/264 (43%), Gaps = 28/264 (10%)

Query: 27   VHPGTARLGSP--DEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQ 84
            ++P T ++ S   DE+      T+    V   +  + +EK +VT       +  + Q L 
Sbjct: 905  INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVT----KREKLELSQRLS 960

Query: 85   NLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCN-- 142
            +L +++KQ   EI    + ++  K+E ++    V+ R R+ +  +++    E +  C+  
Sbjct: 961  DLSEQLKQKHGEISFLNEEVKSLKQEKEQ----VSLRCRELEI-IINHNRAENVQSCDTQ 1015

Query: 143  ---------SMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDT 193
                     +M S   E +V ++ +     +  MV D+   + +  G+       IL   
Sbjct: 1016 VSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHL 1075

Query: 194  QVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVE 253
                +  +  + + SE  +L++ +  L      L  ++E Q     RI  +++ S  +V+
Sbjct: 1076 PSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQ-----RICLSLVYST-HVD 1129

Query: 254  RGQEHVKTALENQKKARKKKVLIA 277
            + +E+++   +    + K++++ A
Sbjct: 1130 QVREYMENEKDKALCSLKEELIFA 1153



 Score = 30.8 bits (68), Expect = 1.5
 Identities = 56/294 (19%), Positives = 130/294 (44%), Gaps = 36/294 (12%)

Query: 4   RTHELRQG---DDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQ 60
           + +E+ Q    ++S+ EE +E+  ++    T  +   +EE   K   ++  +      + 
Sbjct: 306 KVYEMEQDKKVENSNKEEIQEKETIIEELNTKII---EEE--KKTLELKDKLTTADKLLG 360

Query: 61  ELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIE--PQKEEADENYNS- 117
           EL++Q   I+      ++MK EL N + + +Q   EI+  +  +E   ++   D  + + 
Sbjct: 361 ELQEQ---IVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETD 417

Query: 118 -VNTRMRKTQH----------GVLSQQFV----ELINKCNSMQSEYREKNVERIRRQLKI 162
            V    ++TQ            +  QQ V    ELI +  +   E + ++   +   L+ 
Sbjct: 418 IVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRS 477

Query: 163 TNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQAL-NEISARHSEIQQLERSIRELH 221
            +   V+++++ ++++   +E+ +   L+DT   ++ L  E+     E   L+R + +L 
Sbjct: 478 YSNITVNEDQI-KLMNVAINELNIK--LQDTNSQKEKLKEELGLILEEKCALQRQLEDLV 534

Query: 222 DIFTFLATEVEMQGEMINRIEKNI---LSSADYVERGQEHVKTALENQKKARKK 272
           +  +F   +++   + I   E  +     S   VE  +  + +A E++K+   K
Sbjct: 535 EELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 58/277 (20%), Positives = 126/277 (45%), Gaps = 31/277 (11%)

Query: 10  QGDDSSDEEDKERVALVVHPGTA---RLGSPDEEFF---HKVRTIRQTIVKLGNKVQELE 63
           Q  +S  E+ KE + L++    A   +L    EE      +++  RQTI +  +K+ E  
Sbjct: 503 QDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAH 562

Query: 64  KQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMR 123
           K   T+       E +K E+ +  +  K+L  +   ++   + + E  ++  N+V  RM 
Sbjct: 563 KSLSTV-------EDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMA 615

Query: 124 KTQHGVLSQQFVELINKCNSMQSEYREK-------NVERIRRQLKITNAGMVSDEELEQM 176
           ++Q   L +   +L+       S+ +E        N+E+++      N G+   ++++ +
Sbjct: 616 ESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLK-----DNLGIHYKQQIDGL 670

Query: 177 LDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERS-IRELHDIFTFLATEVEMQG 235
            +    ++      KD  +T+Q  N++    S+++ L++S +    +  T    E++ + 
Sbjct: 671 QNEMSQKIETMQFEKDNLITKQ--NQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEI 728

Query: 236 EMINRIEKNILSSADYVERGQEHVKT-ALENQKKARK 271
           E++ + EK   +    V+  Q  +KT  LE Q K ++
Sbjct: 729 EILRQEEKEKGTLEQEVQELQ--LKTELLEKQMKEKE 763



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 70/288 (24%), Positives = 125/288 (43%), Gaps = 55/288 (19%)

Query: 21   ERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQEL-----EKQQVTILATPLP 75
            E++AL     TA     +EE       +++T  K+    QEL     E++ V  + + +P
Sbjct: 2386 EKLALEQQVETA-----NEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS-IP 2439

Query: 76   EESMKQELQNLRDEIKQLGREIRLQ---LKAIEPQ------KEEADENYNSVNTRMRKTQ 126
            E S+   + +L  +  +L  E+ L    LK++E Q      +E    +  ++ TR+ + +
Sbjct: 2440 ENSVNVAIDHLSKDKPEL--EVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLE 2497

Query: 127  HGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITN----------AGMVSDEELEQM 176
              V S + +EL      ++    +   E    Q KI N          A +VS  +LE +
Sbjct: 2498 STV-SAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAV 2556

Query: 177  LDSGQ---------SEVFVSNILKDTQVTRQAL-NEISARHSEIQQLERSIRELHDIFTF 226
             +  +         SE   +NI    Q+    L ++ISA    I +LE  + E+H     
Sbjct: 2557 QEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMH----- 2611

Query: 227  LATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALE-NQKKARKKK 273
              T + ++ E +   EKN+L      E+    ++  LE N+KK R+K+
Sbjct: 2612 --TSLILEKEQVEIAEKNVLEK----EKKLLELQKLLEGNEKKQREKE 2653



 Score = 37.0 bits (84), Expect = 0.021
 Identities = 55/284 (19%), Positives = 110/284 (38%), Gaps = 63/284 (22%)

Query: 39   EEFFHKVRTIRQTIVKLGNKVQELEKQQVTI------LATPLPEESMK------------ 80
            E+    ++   + I KL  +V+ELE+  +             PE S++            
Sbjct: 2133 EQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDR 2192

Query: 81   ----------------QELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRK 124
                            +EL+N  +E++QL  ++ +Q K    + +E ++        M K
Sbjct: 2193 KEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEK 2252

Query: 125  --------------TQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSD 170
                           QH VL  +F ++I +   ++ +   + V ++++QLKIT    V +
Sbjct: 2253 LGLAIKESDAMSTQDQH-VLFGKFAQIIQE-KEVEIDQLNEQVTKLQQQLKITTDNKVIE 2310

Query: 171  EELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATE 230
            E+ E + D    E  +  ++ D +  ++       R  EI+QL   I +L      +  +
Sbjct: 2311 EKNELIRD---LETQIECLMSDQECVKR------NREEEIEQLNEVIEKLQQELANIGQK 2361

Query: 231  VEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKV 274
              M    ++    ++    D V       K ALE Q +   +++
Sbjct: 2362 TSMNAHSLSEEADSLKHQLDVVIA----EKLALEQQVETANEEM 2401



 Score = 33.9 bits (76), Expect = 0.18
 Identities = 34/160 (21%), Positives = 73/160 (45%), Gaps = 12/160 (7%)

Query: 77  ESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVE 136
           E +KQ+   L +EI++         K  E   +E  E Y  +  +++       ++Q +E
Sbjct: 830 EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACL-LKVKDDLEDSKNKQELE 888

Query: 137 LINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEE---LEQMLDSGQ-SEVFVSNILKD 192
             +K  ++  E   + +     ++K      V DE+   + + L+ G+  E   + +++ 
Sbjct: 889 YKSKLKALNEELHLQRINPTTVKMK----SSVFDEDKTFVAETLEMGEVVEKDTTELMEK 944

Query: 193 TQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVE 232
            +VT++   E+S R S+   L   +++ H   +FL  EV+
Sbjct: 945 LEVTKREKLELSQRLSD---LSEQLKQKHGEISFLNEEVK 981



 Score = 31.6 bits (70), Expect = 0.88
 Identities = 49/264 (18%), Positives = 115/264 (43%), Gaps = 28/264 (10%)

Query: 27   VHPGTARLGSP--DEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQ 84
            ++P T ++ S   DE+      T+    V   +  + +EK +VT       +  + Q L 
Sbjct: 905  INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVT----KREKLELSQRLS 960

Query: 85   NLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCN-- 142
            +L +++KQ   EI    + ++  K+E ++    V+ R R+ +  +++    E +  C+  
Sbjct: 961  DLSEQLKQKHGEISFLNEEVKSLKQEKEQ----VSLRCRELEI-IINHNRAENVQSCDTQ 1015

Query: 143  ---------SMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDT 193
                     +M S   E +V ++ +     +  MV D+   + +  G+       IL   
Sbjct: 1016 VSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHL 1075

Query: 194  QVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVE 253
                +  +  + + SE  +L++ +  L      L  ++E Q     RI  +++ S  +V+
Sbjct: 1076 PSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQ-----RICLSLVYST-HVD 1129

Query: 254  RGQEHVKTALENQKKARKKKVLIA 277
            + +E+++   +    + K++++ A
Sbjct: 1130 QVREYMENEKDKALCSLKEELIFA 1153



 Score = 30.8 bits (68), Expect = 1.5
 Identities = 56/294 (19%), Positives = 130/294 (44%), Gaps = 36/294 (12%)

Query: 4   RTHELRQG---DDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQ 60
           + +E+ Q    ++S+ EE +E+  ++    T  +   +EE   K   ++  +      + 
Sbjct: 306 KVYEMEQDKKVENSNKEEIQEKETIIEELNTKII---EEE--KKTLELKDKLTTADKLLG 360

Query: 61  ELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIE--PQKEEADENYNS- 117
           EL++Q   I+      ++MK EL N + + +Q   EI+  +  +E   ++   D  + + 
Sbjct: 361 ELQEQ---IVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETD 417

Query: 118 -VNTRMRKTQH----------GVLSQQFV----ELINKCNSMQSEYREKNVERIRRQLKI 162
            V    ++TQ            +  QQ V    ELI +  +   E + ++   +   L+ 
Sbjct: 418 IVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRS 477

Query: 163 TNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQAL-NEISARHSEIQQLERSIRELH 221
            +   V+++++ ++++   +E+ +   L+DT   ++ L  E+     E   L+R + +L 
Sbjct: 478 YSNITVNEDQI-KLMNVAINELNIK--LQDTNSQKEKLKEELGLILEEKCALQRQLEDLV 534

Query: 222 DIFTFLATEVEMQGEMINRIEKNI---LSSADYVERGQEHVKTALENQKKARKK 272
           +  +F   +++   + I   E  +     S   VE  +  + +A E++K+   K
Sbjct: 535 EELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588


>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
          Length = 1213

 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 63/311 (20%), Positives = 131/311 (42%), Gaps = 58/311 (18%)

Query: 1   MRDRTHELRQGDD------SSDEEDKERVALV---VHPGTARLGSPDEEFFHKV------ 45
           ++D T +LR+ ++      S  +ED++++  +        +R     EE   K+      
Sbjct: 268 VQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESH 327

Query: 46  -RTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAI 104
            R +R  +V L  +++ELE+    +       +  ++ELQ LRD+I +        +  +
Sbjct: 328 NRQLRLKLVGLTQRIEELEETNKNL-------QKAEEELQELRDKIAKGECGNSSLMAEV 380

Query: 105 EPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREK--NVERIRRQLKI 162
           E             N R R  +     ++  +  ++C  ++ + +E+  + + +R +++ 
Sbjct: 381 E-------------NLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEK 427

Query: 163 TNAGMVSDEELEQMLDSGQSEV--FVSNILKDTQVTRQALNEISARHSEIQQLERS---- 216
               M   E+LE+     +SE      N+ K+  +T+  LNE+    S +++LE S    
Sbjct: 428 LQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRL 487

Query: 217 ----------IRELHDIFTFLATEVEMQGEMINRIEKNI--LSSADYVERGQ--EHVKTA 262
                     + +L      L  E +   E I + E+ +  L+    VE+G+  +  +  
Sbjct: 488 EKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKL 547

Query: 263 LENQKKARKKK 273
           +E  KK  K K
Sbjct: 548 IEESKKLLKLK 558



 Score = 28.9 bits (63), Expect = 5.7
 Identities = 51/283 (18%), Positives = 110/283 (38%), Gaps = 58/283 (20%)

Query: 1   MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQ 60
           ++ R  EL + +++  +   E   L  H    +  +  ++  +++  ++  + +L     
Sbjct: 428 LQKRMSELEKLEEAFSKSKSECTQL--HLNLEKEKNLTKDLLNELEVVKSRVKELECSES 485

Query: 61  ELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNT 120
            LEK ++          S+K +L  L+     L  E +  ++ I+ ++ + D     +N 
Sbjct: 486 RLEKAEL----------SLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVD----GLNK 531

Query: 121 RMRKTQHGVL--SQQFVELINKCNSMQSEYREK--NVERIRRQL---------------- 160
             +  Q  V+  +++ +E   K   ++SE  EK  N+ R R +L                
Sbjct: 532 NFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSC 591

Query: 161 --KITNAGMVSDEELEQMLDSGQSE-----------------VFVSNILKDTQVTRQALN 201
              +    +   EE+E+ +  G+S                  + +  + K  Q       
Sbjct: 592 SVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEG 651

Query: 202 EISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKN 244
           ++     E  QLE+  R   D   FL+ ++E   E+ ++I KN
Sbjct: 652 DLMKTEDEYDQLEQKFRTEQDKANFLSQQLE---EIKHQIAKN 691


>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
          Length = 1710

 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 55/264 (20%), Positives = 111/264 (42%), Gaps = 50/264 (18%)

Query: 47   TIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQ--------------NLRDEIKQ 92
            T+ QTI +   ++  L  +   + +    E+  K+ L+              + RD+ + 
Sbjct: 966  TLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSET 1025

Query: 93   LGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEY---- 148
              RE+ L  +    +     +  N   + + K  + +LSQQ  +  +K NS++ E+    
Sbjct: 1026 SKRELELAFQRARDECSRLQDKMNFDVSNL-KDNNEILSQQLFKTESKLNSLEIEFHHTR 1084

Query: 149  ---REK--NVERIRRQLKITNAGMVSDEELEQMLDSGQSEV------------FVSNILK 191
               REK   +ER+++ L  T   M   +E+EQ   + Q +V             +S +  
Sbjct: 1085 DALREKTLGLERVQKDLSQTQCQM---KEMEQKYQNEQVKVNKYIGKQESVEERLSQLQS 1141

Query: 192  DTQVTRQALNEISARHSEIQQLERSI----RELHDIFTFLATEVEMQGEMINRIEKNILS 247
            +  + RQ L++    H++    E+++     + H I   L  E E Q  ++    K ++S
Sbjct: 1142 ENMLLRQQLDD---AHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELIS 1198

Query: 248  SADYVERGQEHVKTALENQKKARK 271
              ++++  Q       EN+K  R+
Sbjct: 1199 ECNHLKERQYQ----YENEKAERE 1218



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 59/295 (20%), Positives = 129/295 (43%), Gaps = 50/295 (16%)

Query: 12   DDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILA 71
            D S+ +++ E ++  +    ++L S + EF H    +R+       K   LE+ Q  +  
Sbjct: 1051 DVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALRE-------KTLGLERVQKDLSQ 1103

Query: 72   TPLPEESMKQELQNLRDEI-KQLGREIRLQLKAIEPQKE------EADENYNSVNTRMR- 123
            T    + M+Q+ QN + ++ K +G++  ++ +  + Q E      + D+ +N  + + + 
Sbjct: 1104 TQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKT 1163

Query: 124  -------------------KTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITN 164
                               + Q  +L ++  ELI++CN ++    +   E+  R++ +  
Sbjct: 1164 VINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQ 1223

Query: 165  AGM-VSDEELEQMLDSGQSEV---FVSNILKDTQ-------VTRQALNEISARHSE---- 209
                ++D   +Q +     EV   +  N+  +TQ         R  L E   RH+E    
Sbjct: 1224 LQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRC 1283

Query: 210  IQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALE 264
             ++++   ++L      L   V+ Q + I  ++KN+L +A+  E  +E +K  +E
Sbjct: 1284 AEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLL-NANLSEDEKEQLKKLME 1337



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 31/221 (14%), Positives = 92/221 (41%), Gaps = 23/221 (10%)

Query: 43   HKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREI----- 97
            HK+  +   +   G+K   L+ +   +    L  ++++++ + L+   K+L +E+     
Sbjct: 1404 HKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRS 1463

Query: 98   -----RLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKN 152
                  ++L  ++  K+E +E          K  +  L  Q     N       ++RE N
Sbjct: 1464 HIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQEN-----LEQFRENN 1518

Query: 153  VERIRRQLKITNAGMVSD----EELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHS 208
               ++ Q+++    + S+    +  ++  +  + E +    L++ +V +   ++++  + 
Sbjct: 1519 FASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNE 1578

Query: 209  EIQQLERSI----RELHDIFTFLATEVEMQGEMINRIEKNI 245
             + ++   +    ++   +FT L T   M+   +  +  ++
Sbjct: 1579 RLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLNNSL 1619


>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
           b [Homo sapiens]
          Length = 882

 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 49/246 (19%), Positives = 109/246 (44%), Gaps = 42/246 (17%)

Query: 39  EEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQ-------------ELQN 85
           +E   K+  ++ +++K   K +ELEKQQ       +  +  KQ             E+Q 
Sbjct: 266 QELEKKLTQVQNSLLK---KEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQK 322

Query: 86  LRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQ 145
           L++ +++  ++ RL  +     KEEA      +    RK Q G+L  +      K +++Q
Sbjct: 323 LKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDK-----QKADTIQ 377

Query: 146 SEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISA 205
              RE  ++ ++++  +      S+ +  + L    SE               AL ++  
Sbjct: 378 ELQRE--LQMLQKESSMAEKEQTSNRKRVEELSLELSE---------------ALRKLEN 420

Query: 206 RHSEIQQLERSIRE----LHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKT 261
              E +QL++++ E    ++D+   +  +   QG +  ++E+++  +   +E  +E +K 
Sbjct: 421 SDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKK 480

Query: 262 ALENQK 267
           + E++K
Sbjct: 481 SKEHEK 486


>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
           a [Homo sapiens]
          Length = 1007

 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 49/246 (19%), Positives = 109/246 (44%), Gaps = 42/246 (17%)

Query: 39  EEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQ-------------ELQN 85
           +E   K+  ++ +++K   K +ELEKQQ       +  +  KQ             E+Q 
Sbjct: 411 QELEKKLTQVQNSLLK---KEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQK 467

Query: 86  LRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQ 145
           L++ +++  ++ RL  +     KEEA      +    RK Q G+L  +      K +++Q
Sbjct: 468 LKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDK-----QKADTIQ 522

Query: 146 SEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISA 205
              RE  ++ ++++  +      S+ +  + L    SE               AL ++  
Sbjct: 523 ELQRE--LQMLQKESSMAEKEQTSNRKRVEELSLELSE---------------ALRKLEN 565

Query: 206 RHSEIQQLERSIRE----LHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKT 261
              E +QL++++ E    ++D+   +  +   QG +  ++E+++  +   +E  +E +K 
Sbjct: 566 SDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKK 625

Query: 262 ALENQK 267
           + E++K
Sbjct: 626 SKEHEK 631


>gi|10864047 epidermal growth factor receptor pathway substrate
           15-like 1 [Homo sapiens]
          Length = 864

 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 39/179 (21%), Positives = 80/179 (44%), Gaps = 18/179 (10%)

Query: 45  VRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAI 104
           +R   + I +  ++VQEL+       ++    E+ KQ+ Q+  DE+ Q   ++R  L  +
Sbjct: 407 IREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDV 466

Query: 105 EPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITN 164
             + ++  +  +S+ T+++  +  + SQ+     +  N  +SE      E  + +  I  
Sbjct: 467 RQKCQDETQMISSLKTQIQSQESDLKSQE-----DDLNRAKSELNRLQQEETQLEQSI-Q 520

Query: 165 AGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDI 223
           AG V  E + + L S Q E+             QA +++S  H   Q+  RS+ +   +
Sbjct: 521 AGRVQLETIIKSLKSTQDEI------------NQARSKLSQLHESRQEAHRSLEQYDQV 567


>gi|219521893 coiled-coil transcriptional coactivator isoform 2
           [Homo sapiens]
          Length = 606

 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 60/236 (25%), Positives = 113/236 (47%), Gaps = 25/236 (10%)

Query: 58  KVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGRE---IRLQLKAIEPQKEEADEN 114
           ++ ELE    TI    L +E    EL  LRD +K L RE   +  QLK ++  KE+++  
Sbjct: 196 RILELEDDIQTISEKVLTKEV---ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAE 252

Query: 115 YNSVNTRMRKTQH-GVLSQQFVELINKCNSMQSEYREKNVERIRR-QLKITNA-GMVSDE 171
              +  ++R  Q     SQQ   L+ +  +  +  R++ +  + R +L++    G +++ 
Sbjct: 253 LEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAEL 312

Query: 172 ELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRE---LHDIF-TFL 227
            L    +  Q     + +L+  +  +  + ++SA   EI +LE++++E    + +F T L
Sbjct: 313 GLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSA---EILRLEKAVQEERTQNQVFKTEL 369

Query: 228 ATEVEMQGEMINRIEKNI--LSSADYV-----ERGQEHVKTALENQKK--ARKKKV 274
           A E +     ++  ++ +  L SA  V     E+ QE  +  LE  +K  AR +KV
Sbjct: 370 AREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKV 425


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
           [Homo sapiens]
          Length = 1354

 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 58/283 (20%), Positives = 119/283 (42%), Gaps = 53/283 (18%)

Query: 40  EFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPE------------ESMKQELQNLR 87
           E   K++  R+   K  N+V ++EKQ  ++L   L +            E M+ E++NL 
Sbjct: 715 EMEKKLKEEREAREKAENRVVQIEKQ-CSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLT 773

Query: 88  DEIKQ-------LGREIRLQ------LKAIEPQ-KEEAD-----------------ENYN 116
            +++Q       L  E++ Q      LK +E Q K+E +                 + Y 
Sbjct: 774 LQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYR 833

Query: 117 SVNTRMRKTQHGVLSQQFVELINK--CNSMQSEYREKNVERIRRQLKITNAGMVSDEELE 174
               +MR+ Q  + ++Q+   + K     ++ E  EKN E +++  ++ N       +L+
Sbjct: 834 GNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLD 893

Query: 175 QMLDSGQSEVFVSNILKDT--QVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVE 232
                 +SE     +L++   ++T+++    S    EI   + ++  L +  + L  ++E
Sbjct: 894 LAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIE 953

Query: 233 -MQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKV 274
            ++ E     EK   +  +Y    +E +     N K A +K +
Sbjct: 954 ILRRENEELTEKMKKAEEEYKLEKEEEI----SNLKAAFEKNI 992



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 40/206 (19%), Positives = 97/206 (47%), Gaps = 18/206 (8%)

Query: 80   KQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQ--HGVLSQQFVEL 137
            K +++ L++EI++  RE   +++ ++ +KE      +   T+    Q   G+L +Q+ EL
Sbjct: 857  KTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFEL 916

Query: 138  INKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTR 197
              +     S  R++  ++     ++  A  +  +++E +L     E+        T+  +
Sbjct: 917  TQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIE-ILRRENEEL--------TEKMK 967

Query: 198  QALNEIS-ARHSEIQQLERSI-RELHDIFTFLATEVEMQGEMINR----IEKNILSSADY 251
            +A  E    +  EI  L+ +  + ++   T     V    E++NR    I++   ++ D 
Sbjct: 968  KAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDL 1027

Query: 252  VERGQEHVKTALE-NQKKARKKKVLI 276
             ++ +E+ K  LE NQ++ +  ++++
Sbjct: 1028 RKKEKENRKLQLELNQEREKFNQMVV 1053



 Score = 33.9 bits (76), Expect = 0.18
 Identities = 35/196 (17%), Positives = 83/196 (42%), Gaps = 15/196 (7%)

Query: 76  EESMKQELQNLRDEIKQLGREIRLQL-KAIEPQKEEADENYNSVNTRMRKTQHGVLSQQF 134
           EE +  E+Q L+DE++Q  R   ++L K ++   EE ++  N  +T  +  +  +L Q  
Sbjct: 436 EEQLHNEMQ-LKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHR 494

Query: 135 VELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQ 194
           +          +EY+ K  +   ++  + N      ++LE +    Q+    +  L   Q
Sbjct: 495 I----------NEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQ 544

Query: 195 VTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVER 254
              +  N++    S+       +R+ H   +   +++E     +    + + +S    ++
Sbjct: 545 KQLEEANDLLRTESDTAV---RLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDK 601

Query: 255 GQEHVKTALENQKKAR 270
               ++  LE +++ R
Sbjct: 602 DYYQLQAILEAERRDR 617


>gi|31652238 cut-like homeobox 1 isoform c [Homo sapiens]
          Length = 676

 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 47/220 (21%), Positives = 99/220 (45%), Gaps = 22/220 (10%)

Query: 48  IRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQ 107
           +R+T+ +   +  E++ Q+VTI A              L+++I++  + ++ Q + I  +
Sbjct: 129 LRETLEEYNKEFAEVKNQEVTIKA--------------LKEKIREYEQTLKNQAETIALE 174

Query: 108 KEEADEN-YNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAG 166
           KE+  +N +     ++++TQ    S +  E  +K  S+Q+   +   E    + K     
Sbjct: 175 KEQKLQNDFAEKERKLQETQMSTTS-KLEEAEHKVQSLQTALEKTRTELFDLKTKYDEET 233

Query: 167 MVSDEELEQ-MLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFT 225
               +E+E  M D  ++        ++ +  R+ L+  SA HS   QL   I++  D+  
Sbjct: 234 TAKADEIEMIMTDLERANQRAEVAQREAETLREQLS--SANHS--LQLASQIQKAPDVAI 289

Query: 226 FLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALEN 265
            + T   ++ E+  + E+ I    + V+R Q  +    EN
Sbjct: 290 EVLTRSSLEVELAAK-EREIAQLVEDVQRLQASLTKLREN 328


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.339 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,540,929
Number of Sequences: 37866
Number of extensions: 395081
Number of successful extensions: 2723
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 394
Number of HSP's that attempted gapping in prelim test: 2060
Number of HSP's gapped (non-prelim): 954
length of query: 297
length of database: 18,247,518
effective HSP length: 102
effective length of query: 195
effective length of database: 14,385,186
effective search space: 2805111270
effective search space used: 2805111270
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.