Search of human proteins with 20127450

Search of human proteins with 20127450

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
         (673 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]          1409   0.0  
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]          1344   0.0  
gi|4506067 protein kinase C, alpha [Homo sapiens]                    1148   0.0  
gi|13384594 protein kinase C, gamma [Homo sapiens]                   1006   0.0  
gi|4885563 protein kinase C, epsilon [Homo sapiens]                   585   e-167
gi|28557781 protein kinase C, eta [Homo sapiens]                      402   e-112
gi|5453976 protein kinase C, theta [Homo sapiens]                     382   e-106
gi|47157325 protein kinase C, delta [Homo sapiens]                    375   e-104
gi|31377782 protein kinase C, delta [Homo sapiens]                    375   e-104
gi|133908623 protein kinase C, iota [Homo sapiens]                    369   e-102
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]           362   e-100
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]           362   e-100
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]           362   e-100
gi|5453974 protein kinase N2 [Homo sapiens]                           324   2e-88
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       320   4e-87
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      320   4e-87
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]                319   5e-87
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]                319   5e-87
gi|4502023 AKT2 kinase [Homo sapiens]                                 316   5e-86
gi|62241015 AKT1 kinase [Homo sapiens]                                315   9e-86
gi|62241013 AKT1 kinase [Homo sapiens]                                315   9e-86
gi|62241011 AKT1 kinase [Homo sapiens]                                315   9e-86
gi|40254851 protein kinase PKNbeta [Homo sapiens]                     303   3e-82
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   287   2e-77
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   287   2e-77
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   287   2e-77
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [...   287   2e-77
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta...   275   1e-73
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph...   273   4e-73
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   271   1e-72

>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score = 1409 bits (3646), Expect = 0.0
 Identities = 673/673 (100%), Positives = 673/673 (100%)

Query: 1   MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF 60
           MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
Sbjct: 1   MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF 60

Query: 61  GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS 120
           GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
Sbjct: 61  GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS 120

Query: 121 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA 180
           LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
Sbjct: 121 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA 180

Query: 181 KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL 240
           KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
Sbjct: 181 KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL 240

Query: 241 SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE 300
           SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
Sbjct: 241 SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE 300

Query: 301 LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE 360
           LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
Sbjct: 301 LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE 360

Query: 361 RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM 420
           RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
Sbjct: 361 RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM 420

Query: 421 EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI 480
           EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
Sbjct: 421 EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI 480

Query: 481 KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP 540
           KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
Sbjct: 481 KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP 540

Query: 541 FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600
           FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
Sbjct: 541 FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600

Query: 601 RYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFS 660
           RYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFS
Sbjct: 601 RYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFS 660

Query: 661 FVNSEFLKPEVKS 673
           FVNSEFLKPEVKS
Sbjct: 661 FVNSEFLKPEVKS 673


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score = 1344 bits (3479), Expect = 0.0
 Identities = 645/668 (96%), Positives = 652/668 (97%), Gaps = 1/668 (0%)

Query: 1   MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF 60
           MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
Sbjct: 1   MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF 60

Query: 61  GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS 120
           GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
Sbjct: 61  GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS 120

Query: 121 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA 180
           LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
Sbjct: 121 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA 180

Query: 181 KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL 240
           KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
Sbjct: 181 KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL 240

Query: 241 SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE 300
           SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
Sbjct: 241 SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE 300

Query: 301 LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE 360
           LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
Sbjct: 301 LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE 360

Query: 361 RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM 420
           RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
Sbjct: 361 RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM 420

Query: 421 EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI 480
           EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
Sbjct: 421 EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI 480

Query: 481 KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP 540
           KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
Sbjct: 481 KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP 540

Query: 541 FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600
           FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
Sbjct: 541 FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600

Query: 601 RYIDWEKLERKEIQPPYKPKACG-RNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGF 659
           RYIDWEKLERKEIQPPYKPKA   R+  NFD+ FTR P  LTP D+  I N+DQ+EF GF
Sbjct: 601 RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF 660

Query: 660 SFVNSEFL 667
           S+ N EF+
Sbjct: 661 SYTNPEFV 668


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score = 1148 bits (2969), Expect = 0.0
 Identities = 541/674 (80%), Positives = 601/674 (89%), Gaps = 5/674 (0%)

Query: 1   MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF 60
           MAD   G   +  ++   RFARKGALRQKNVHEVK+HKF ARFFKQPTFCSHCTDFIWGF
Sbjct: 1   MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF 60

Query: 61  GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS 120
           GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGP +DDPRSKHKFKIHTY SPTFCDHCGS
Sbjct: 61  GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS 120

Query: 121 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA 180
           LLYGLIHQGMKCDTC MNVHK+CV+NVPSLCG DHTE+RGRIY++A +  + L V VRDA
Sbjct: 121 LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA 180

Query: 181 KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL 240
           KNL+PMDPNGLSDPYVKLKLIPDPK+ESKQKTKTI+ +LNP+WNE+F F+LK SDKDRRL
Sbjct: 181 KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL 240

Query: 241 SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE 300
           SVEIWDWD T+RNDFMGSLSFG+SEL K    GW+KLL+QEEGEY+NVP+P    E N E
Sbjct: 241 SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME 300

Query: 301 LRQKFERAKISQ-GTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLS 359
           LRQKFE+AK+   G KV     + +  +   + N DR+KLTDFNFLMVLGKGSFGKVML+
Sbjct: 301 LRQKFEKAKLGPAGNKV----ISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLA 356

Query: 360 ERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFV 419
           +RKGT+ELYA+KILKKDVVIQDDDVECTMVEKRVLAL  KPPFLTQLHSCFQT+DRLYFV
Sbjct: 357 DRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFV 416

Query: 420 MEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH 479
           MEYVNGGDLMYHIQQVG+FKEP AVFYAAEI+IGLFFL  +GIIYRDLKLDNVMLDSEGH
Sbjct: 417 MEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGH 476

Query: 480 IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQA 539
           IKIADFGMCKE++ DGVTT+TFCGTPDYIAPEIIAYQPYGKSVDWWA+GVLLYEMLAGQ 
Sbjct: 477 IKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQP 536

Query: 540 PFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAF 599
           PF+GEDEDELFQSIMEHNV+YPKS+SKEAV+ICKGLMTKHP KRLGCGPEGERD++EHAF
Sbjct: 537 PFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAF 596

Query: 600 FRYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGF 659
           FR IDWEKLE +EIQPP+KPK CG+ AENFD+FFTR  PVLTPPDQ VI NIDQS+FEGF
Sbjct: 597 FRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGF 656

Query: 660 SFVNSEFLKPEVKS 673
           S+VN +F+ P ++S
Sbjct: 657 SYVNPQFVHPILQS 670


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score = 1006 bits (2600), Expect = 0.0
 Identities = 479/691 (69%), Positives = 566/691 (81%), Gaps = 22/691 (3%)

Query: 1   MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF 60
           MA    G   SEG    + F RKGALRQK VHEVK+HKFTARFFKQPTFCSHCTDFIWG 
Sbjct: 1   MAGLGPGVGDSEGGPRPL-FCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGI 59

Query: 61  GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS 120
           GKQG QCQVC FVVH+RCHEFVTF CPGA KGP +DDPR+KHKF++H+YSSPTFCDHCGS
Sbjct: 60  GKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGS 119

Query: 121 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDR-DVLIVLVRD 179
           LLYGL+HQGMKC  C MNVH+RCV +VPSLCG DHTERRGR+ ++      D + V V +
Sbjct: 120 LLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGE 179

Query: 180 AKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRR 239
           A+NL+PMDPNGLSDPYVKLKLIPDP++ +KQKT+T+K +LNP WNETF F LK  D +RR
Sbjct: 180 ARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERR 239

Query: 240 LSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANE 299
           LSVE+WDWD TSRNDFMG++SFG+SEL KA VDGW+KLL+QEEGEY+NVPV       N 
Sbjct: 240 LSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPV---ADADNC 296

Query: 300 ELRQKFERA--------KISQG---TKVPEEKTTNTVSKFDNNG-NRDRMKLTDFNFLMV 347
            L QKFE          ++  G   + +P    + T  K    G +  R+ ++DF+FLMV
Sbjct: 297 SLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMV 356

Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP-----F 402
           LGKGSFGKVML+ER+G+DELYA+KILKKDV++QDDDV+CT+VEKRVLAL G+ P     F
Sbjct: 357 LGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHF 416

Query: 403 LTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGI 462
           LTQLHS FQT DRLYFVMEYV GGDLMYHIQQ+G+FKEPHA FYAAEIAIGLFFL ++GI
Sbjct: 417 LTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGI 476

Query: 463 IYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSV 522
           IYRDLKLDNVMLD+EGHIKI DFGMCKEN++ G TT+TFCGTPDYIAPEIIAYQPYGKSV
Sbjct: 477 IYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSV 536

Query: 523 DWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGK 582
           DWW+FGVLLYEMLAGQ PF+GEDE+ELFQ+IME  V YPKS+S+EAVAICKG +TKHPGK
Sbjct: 537 DWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGK 596

Query: 583 RLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTP 642
           RLG GP+GE  I+ H FFR+IDWE+LER EI PP++P+ CGR+ ENFD+FFTR  P LTP
Sbjct: 597 RLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTP 656

Query: 643 PDQEVIRNIDQSEFEGFSFVNSEFLKPEVKS 673
           PD+ V+ +IDQ++F+GF++VN +F+ P+ +S
Sbjct: 657 PDRLVLASIDQADFQGFTYVNPDFVHPDARS 687


>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score =  585 bits (1508), Expect = e-167
 Identities = 313/680 (46%), Positives = 403/680 (59%), Gaps = 94/680 (13%)

Query: 5   AAGPPPSEGEESTVRFA-----RKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWG 59
           ++G  P + EE   R       R+GA+R++ VH+V  HKF A + +QPT+CSHC DFIWG
Sbjct: 134 SSGEAPKDNEERVFRERMRPRKRQGAVRRR-VHQVNGHKFMATYLRQPTYCSHCRDFIWG 192

Query: 60  -FGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSK-------HKFKIHTYSS 111
             GKQG+QCQVC  VVHKRCHE +   C G  K    D   S+       HKF IH Y  
Sbjct: 193 VIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKV 252

Query: 112 PTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRD 171
           PTFCDHCGSLL+GL+ QG++C  C MNVH+RC  NV   CG                   
Sbjct: 253 PTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCG------------------- 293

Query: 172 VLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL 231
                         +D  G++     L + PD  + S Q+ K +                
Sbjct: 294 --------------VDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESP-QPASGSSP 338

Query: 232 KESDKDRRLSVEIWDWDLTS-RNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPV 290
            E D+ +       D ++    N+   +LSF                     GE      
Sbjct: 339 SEEDRSKSAPTSPCDQEIKELENNIRKALSF------------------DNRGEEHRAAS 380

Query: 291 PPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGK 350
            P+G     +L    E  ++ QG                      R+ L +FNF+ VLGK
Sbjct: 381 SPDG-----QLMSPGENGEVRQG-------------------QAKRLGLDEFNFIKVLGK 416

Query: 351 GSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCF 410
           GSFGKVML+E KG DE+YAVK+LKKDV++QDDDV+CTM EKR+LAL  K P+LTQL+ CF
Sbjct: 417 GSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCF 476

Query: 411 QTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLD 470
           QT DRL+FVMEYVNGGDLM+ IQ+  +F EP + FYAAE+   L FL   G+IYRDLKLD
Sbjct: 477 QTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLD 536

Query: 471 NVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVL 530
           N++LD+EGH K+ADFGMCKE I +GVTT TFCGTPDYIAPEI+    YG SVDWWA GVL
Sbjct: 537 NILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVL 596

Query: 531 LYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGC--GP 588
           +YEM+AGQ PFE ++ED+LF+SI+  +V YP  +SKEAV+I K  MTK+P KRLGC    
Sbjct: 597 MYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQ 656

Query: 589 EGERDIKEHAFFRYIDWEKLERKEIQPPYKPK-ACGRNAENFDRFFTRHPPVLTPPDQEV 647
            GE  IK+H FF+ IDW  LE+K+I+PP+KP+    R+  NFD+ FTR  PVLT  D+ +
Sbjct: 657 NGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAI 716

Query: 648 IRNIDQSEFEGFSFVNSEFL 667
           ++ I+Q EF+GFS+   + +
Sbjct: 717 VKQINQEEFKGFSYFGEDLM 736


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  402 bits (1032), Expect = e-112
 Identities = 198/333 (59%), Positives = 244/333 (73%), Gaps = 2/333 (0%)

Query: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVL 394
           +R+ + +F F+ VLGKGSFGKVML+  K T +LYAVK+LKKDV++QDDDVECTM EKR+L
Sbjct: 348 NRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRIL 407

Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454
           +L    PFLTQL  CFQT DRL+FVME+VNGGDLM+HIQ+  RF E  A FYAAEI   L
Sbjct: 408 SLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 467

Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514
            FL  KGIIYRDLKLDNV+LD EGH K+ADFGMCKE I +GVTT TFCGTPDYIAPEI+ 
Sbjct: 468 MFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQ 527

Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574
              YG +VDWWA GVLLYEML G APFE E+ED+LF++I+   V YP  + ++A  I K 
Sbjct: 528 EMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKS 587

Query: 575 LMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRF 632
            MTK+P  RLG   + GE  I  H FF+ IDW +L  ++I+PP++P+   R +  NFD  
Sbjct: 588 FMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPD 647

Query: 633 FTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSE 665
           F +  PVLTP D+  +  I+Q EF  FS+V+ E
Sbjct: 648 FIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE 680



 Score =  158 bits (400), Expect = 1e-38
 Identities = 72/145 (49%), Positives = 94/145 (64%), Gaps = 10/145 (6%)

Query: 22  RKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWG-FGKQGFQCQVCCFVVHKRCHE 80
           R+ A+R++ VH++  HKF A + +QPT+CSHC +FIWG FGKQG+QCQVC  VVHKRCH 
Sbjct: 158 RQRAMRRR-VHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHH 216

Query: 81  FVTFSCPGADKGPASDDPRSK--------HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKC 132
            +  +C   +     D   ++        HKF IH Y  PTFCDHCGSLL+G++ QG++C
Sbjct: 217 LIVTACTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQC 276

Query: 133 DTCMMNVHKRCVMNVPSLCGTDHTE 157
             C MNVH RC  NV   CG +  E
Sbjct: 277 KICKMNVHIRCQANVAPNCGVNAVE 301


>gi|5453976 protein kinase C, theta [Homo sapiens]
          Length = 706

 Score =  382 bits (980), Expect = e-106
 Identities = 189/329 (57%), Positives = 236/329 (71%), Gaps = 5/329 (1%)

Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395
           ++K+ DF    +LGKGSFGKV L+E K T++ +A+K LKKDVV+ DDDVECTMVEKRVL+
Sbjct: 374 KLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 433

Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455
           L  + PFLT +   FQT + L+FVMEY+NGGDLMYHIQ   +F    A FYAAEI +GL 
Sbjct: 434 LAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 493

Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515
           FL SKGI+YRDLKLDN++LD +GHIKIADFGMCKEN+     T TFCGTPDYIAPEI+  
Sbjct: 494 FLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLG 553

Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575
           Q Y  SVDWW+FGVLLYEML GQ+PF G+DE+ELF SI   N  YP+ + KEA  +   L
Sbjct: 554 QKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKL 613

Query: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRFFT 634
             + P KRLG       DI++H  FR I+WE+LERKEI PP++PK     +  NFD+ F 
Sbjct: 614 FVREPEKRLGV----RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFL 669

Query: 635 RHPPVLTPPDQEVIRNIDQSEFEGFSFVN 663
              P L+  D+ +I ++DQ+ F  FSF+N
Sbjct: 670 NEKPRLSFADRALINSMDQNMFRNFSFMN 698



 Score =  157 bits (396), Expect = 4e-38
 Identities = 70/138 (50%), Positives = 91/138 (65%), Gaps = 7/138 (5%)

Query: 22  RKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 81
           R+GA++Q  VH VK H+FTA FF QPTFCS C +F+WG  KQG+QC+ C   +HK+C + 
Sbjct: 145 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDK 204

Query: 82  VTFSCPGA---DKGPASDDPRSK----HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDT 134
           V   C G+    +       R K    H+FK++ Y SPTFC+HCG+LL+GL  QG+KCD 
Sbjct: 205 VIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDA 264

Query: 135 CMMNVHKRCVMNVPSLCG 152
           C MNVH RC   V +LCG
Sbjct: 265 CGMNVHHRCQTKVANLCG 282


>gi|47157325 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score =  375 bits (964), Expect = e-104
 Identities = 193/332 (58%), Positives = 236/332 (71%), Gaps = 5/332 (1%)

Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395
           +  + +F F  VLGKGSFGKV+L E KG  E +A+K LKKDVV+ DDDVECTMVEKRVL 
Sbjct: 343 KCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLT 402

Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455
           L  + PFLT L   FQT D L+FVME++NGGDLMYHIQ  GRF+   A FYAAEI  GL 
Sbjct: 403 LAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQ 462

Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515
           FL SKGIIYRDLKLDNV+LD +GHIKIADFGMCKENI+      TFCGTPDYIAPEI+  
Sbjct: 463 FLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQG 522

Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575
             Y  SVDWW+FGVLLYEML GQ+PF G+DEDELF+SI      YP+ ++KE+  I + L
Sbjct: 523 LKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKL 582

Query: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKA-CGRNAENFDRFFT 634
             + P KRLG       +IK H FF+ I+W  LE++ ++PP++PK    R+  NFD+ F 
Sbjct: 583 FEREPTKRLGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFL 638

Query: 635 RHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEF 666
                L+  D+ +I ++DQS F GFSFVN +F
Sbjct: 639 NEKARLSYSDKNLIDSMDQSAFAGFSFVNPKF 670



 Score =  158 bits (400), Expect = 1e-38
 Identities = 69/149 (46%), Positives = 93/149 (62%), Gaps = 7/149 (4%)

Query: 11  SEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVC 70
           SE E       R+GA++Q  +H +KNH+F A FF QPTFCS C DF+WG  KQG++C+ C
Sbjct: 133 SEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQC 192

Query: 71  CFVVHKRCHEFVTFSCPGADKGPASDDPRSK-------HKFKIHTYSSPTFCDHCGSLLY 123
              +HK+C + +   C G          + +       H+FK+H Y SPTFCDHCGSLL+
Sbjct: 193 NAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLW 252

Query: 124 GLIHQGMKCDTCMMNVHKRCVMNVPSLCG 152
           GL+ QG+KC+ C MNVH +C   V +LCG
Sbjct: 253 GLVKQGLKCEDCGMNVHHKCREKVANLCG 281



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 21/71 (29%), Positives = 33/71 (46%)

Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGR 161
           H+F    +  PTFC  C   ++GL  QG KC  C   +HK+C+  +   C       R  
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218

Query: 162 IYIQAHIDRDV 172
           I+ +   + D+
Sbjct: 219 IFQKERFNIDM 229


>gi|31377782 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score =  375 bits (964), Expect = e-104
 Identities = 193/332 (58%), Positives = 236/332 (71%), Gaps = 5/332 (1%)

Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395
           +  + +F F  VLGKGSFGKV+L E KG  E +A+K LKKDVV+ DDDVECTMVEKRVL 
Sbjct: 343 KCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLT 402

Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455
           L  + PFLT L   FQT D L+FVME++NGGDLMYHIQ  GRF+   A FYAAEI  GL 
Sbjct: 403 LAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQ 462

Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515
           FL SKGIIYRDLKLDNV+LD +GHIKIADFGMCKENI+      TFCGTPDYIAPEI+  
Sbjct: 463 FLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQG 522

Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575
             Y  SVDWW+FGVLLYEML GQ+PF G+DEDELF+SI      YP+ ++KE+  I + L
Sbjct: 523 LKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKL 582

Query: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKA-CGRNAENFDRFFT 634
             + P KRLG       +IK H FF+ I+W  LE++ ++PP++PK    R+  NFD+ F 
Sbjct: 583 FEREPTKRLGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFL 638

Query: 635 RHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEF 666
                L+  D+ +I ++DQS F GFSFVN +F
Sbjct: 639 NEKARLSYSDKNLIDSMDQSAFAGFSFVNPKF 670



 Score =  158 bits (400), Expect = 1e-38
 Identities = 69/149 (46%), Positives = 93/149 (62%), Gaps = 7/149 (4%)

Query: 11  SEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVC 70
           SE E       R+GA++Q  +H +KNH+F A FF QPTFCS C DF+WG  KQG++C+ C
Sbjct: 133 SEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQC 192

Query: 71  CFVVHKRCHEFVTFSCPGADKGPASDDPRSK-------HKFKIHTYSSPTFCDHCGSLLY 123
              +HK+C + +   C G          + +       H+FK+H Y SPTFCDHCGSLL+
Sbjct: 193 NAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLW 252

Query: 124 GLIHQGMKCDTCMMNVHKRCVMNVPSLCG 152
           GL+ QG+KC+ C MNVH +C   V +LCG
Sbjct: 253 GLVKQGLKCEDCGMNVHHKCREKVANLCG 281



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 21/71 (29%), Positives = 33/71 (46%)

Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGR 161
           H+F    +  PTFC  C   ++GL  QG KC  C   +HK+C+  +   C       R  
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218

Query: 162 IYIQAHIDRDV 172
           I+ +   + D+
Sbjct: 219 IFQKERFNIDM 229


>gi|133908623 protein kinase C, iota [Homo sapiens]
          Length = 596

 Score =  369 bits (947), Expect = e-102
 Identities = 175/343 (51%), Positives = 238/343 (69%), Gaps = 11/343 (3%)

Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
           L DF+ L V+G+GS+ KV+L   K TD +YA+K++KK++V  D+D++    EK V     
Sbjct: 251 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 310

Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
             PFL  LHSCFQT  RL+FV+EYVNGGDLM+H+Q+  +  E HA FY+AEI++ L +L 
Sbjct: 311 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLH 370

Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
            +GIIYRDLKLDNV+LDSEGHIK+ D+GMCKE +  G TT TFCGTP+YIAPEI+  + Y
Sbjct: 371 ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY 430

Query: 519 GKSVDWWAFGVLLYEMLAGQAPF---------EGEDEDELFQSIMEHNVAYPKSMSKEAV 569
           G SVDWWA GVL++EM+AG++PF         +   ED LFQ I+E  +  P+S+S +A 
Sbjct: 431 GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAA 490

Query: 570 AICKGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAE 627
           ++ K  + K P +RLGC P+ G  DI+ H FFR +DW+ +E+K++ PP+KP   G    +
Sbjct: 491 SVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLD 550

Query: 628 NFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFLKPE 670
           NFD  FT  P  LTP D +++R IDQSEFEGF ++N   +  E
Sbjct: 551 NFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAE 593



 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 31/77 (40%), Positives = 47/77 (61%), Gaps = 2/77 (2%)

Query: 10  PSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQV 69
           P  GE+ ++   R+GA R + ++    H F A+ F +   C+ CTD IWG G+QG++C  
Sbjct: 116 PCPGEDKSIY--RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCIN 173

Query: 70  CCFVVHKRCHEFVTFSC 86
           C  +VHK+CH+ VT  C
Sbjct: 174 CKLLVHKKCHKLVTIEC 190



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 24/75 (32%), Positives = 32/75 (42%), Gaps = 8/75 (10%)

Query: 86  CPGADKGPASDDPR--------SKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMM 137
           CPG DK       R        + H F+   ++    C  C   ++GL  QG KC  C +
Sbjct: 117 CPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKL 176

Query: 138 NVHKRCVMNVPSLCG 152
            VHK+C   V   CG
Sbjct: 177 LVHKKCHKLVTIECG 191


>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  362 bits (929), Expect = e-100
 Identities = 176/341 (51%), Positives = 235/341 (68%), Gaps = 9/341 (2%)

Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
           L DF+ + V+G+GS+ KV+L   K  D++YA+K++KK++V  D+D++    EK V     
Sbjct: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125

Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
             PFL  LHSCFQT  RL+ V+EYVNGGDLM+H+Q+  +  E HA FYAAEI I L FL 
Sbjct: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185

Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
            +GIIYRDLKLDNV+LD++GHIK+ D+GMCKE +  G TT TFCGTP+YIAPEI+  + Y
Sbjct: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245

Query: 519 GKSVDWWAFGVLLYEMLAGQAPF-------EGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571
           G SVDWWA GVL++EM+AG++PF       +   ED LFQ I+E  +  P+ +S +A  +
Sbjct: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305

Query: 572 CKGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKAC-GRNAENF 629
            KG + K P +RLGC P+ G  DIK HAFFR IDW+ LE+K+  PP++P+       +NF
Sbjct: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365

Query: 630 DRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFLKPE 670
           D  FT  P  LTP D++ I+ IDQSEFEGF ++N   L  E
Sbjct: 366 DTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTE 406


>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  362 bits (929), Expect = e-100
 Identities = 176/341 (51%), Positives = 235/341 (68%), Gaps = 9/341 (2%)

Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
           L DF+ + V+G+GS+ KV+L   K  D++YA+K++KK++V  D+D++    EK V     
Sbjct: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125

Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
             PFL  LHSCFQT  RL+ V+EYVNGGDLM+H+Q+  +  E HA FYAAEI I L FL 
Sbjct: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185

Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
            +GIIYRDLKLDNV+LD++GHIK+ D+GMCKE +  G TT TFCGTP+YIAPEI+  + Y
Sbjct: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245

Query: 519 GKSVDWWAFGVLLYEMLAGQAPF-------EGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571
           G SVDWWA GVL++EM+AG++PF       +   ED LFQ I+E  +  P+ +S +A  +
Sbjct: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305

Query: 572 CKGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKAC-GRNAENF 629
            KG + K P +RLGC P+ G  DIK HAFFR IDW+ LE+K+  PP++P+       +NF
Sbjct: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365

Query: 630 DRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFLKPE 670
           D  FT  P  LTP D++ I+ IDQSEFEGF ++N   L  E
Sbjct: 366 DTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTE 406


>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
          Length = 592

 Score =  362 bits (929), Expect = e-100
 Identities = 176/341 (51%), Positives = 235/341 (68%), Gaps = 9/341 (2%)

Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
           L DF+ + V+G+GS+ KV+L   K  D++YA+K++KK++V  D+D++    EK V     
Sbjct: 249 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 308

Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
             PFL  LHSCFQT  RL+ V+EYVNGGDLM+H+Q+  +  E HA FYAAEI I L FL 
Sbjct: 309 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 368

Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
            +GIIYRDLKLDNV+LD++GHIK+ D+GMCKE +  G TT TFCGTP+YIAPEI+  + Y
Sbjct: 369 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 428

Query: 519 GKSVDWWAFGVLLYEMLAGQAPF-------EGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571
           G SVDWWA GVL++EM+AG++PF       +   ED LFQ I+E  +  P+ +S +A  +
Sbjct: 429 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 488

Query: 572 CKGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKAC-GRNAENF 629
            KG + K P +RLGC P+ G  DIK HAFFR IDW+ LE+K+  PP++P+       +NF
Sbjct: 489 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 548

Query: 630 DRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFLKPE 670
           D  FT  P  LTP D++ I+ IDQSEFEGF ++N   L  E
Sbjct: 549 DTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTE 589



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 28/77 (36%), Positives = 45/77 (58%), Gaps = 2/77 (2%)

Query: 10  PSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQV 69
           P  GE+ ++   R+GA R + ++    H F A+ F +  +C  C++ IWG  +QG++C  
Sbjct: 106 PCPGEDKSIY--RRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCIN 163

Query: 70  CCFVVHKRCHEFVTFSC 86
           C  +VHKRCH  V  +C
Sbjct: 164 CKLLVHKRCHGLVPLTC 180



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 24/74 (32%), Positives = 33/74 (44%), Gaps = 8/74 (10%)

Query: 86  CPGADKGPASDDPR--------SKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMM 137
           CPG DK       R        + H F+   ++   +C  C   ++GL  QG +C  C +
Sbjct: 107 CPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKL 166

Query: 138 NVHKRCVMNVPSLC 151
            VHKRC   VP  C
Sbjct: 167 LVHKRCHGLVPLTC 180


>gi|5453974 protein kinase N2 [Homo sapiens]
          Length = 984

 Score =  324 bits (830), Expect = 2e-88
 Identities = 156/333 (46%), Positives = 221/333 (66%), Gaps = 5/333 (1%)

Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393
           R +  L DF    VLG+G FGKV+L+E K T+E++A+K LKK  ++  D+V+  M EKR+
Sbjct: 649 RFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRI 708

Query: 394 LALPG--KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451
                  + PFL  L +CFQT + + FVMEY  GGDLM HI     F EP AVFYAA + 
Sbjct: 709 FETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-TDVFSEPRAVFYAACVV 767

Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511
           +GL +L    I+YRDLKLDN++LD+EG +KIADFG+CKE +  G  T TFCGTP+++APE
Sbjct: 768 LGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 827

Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571
           ++    Y ++VDWW  GVL+YEML G++PF G+DE+E+F SI+   V YP+ +S EA++I
Sbjct: 828 VLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISI 887

Query: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFD 630
            + L+ ++P +RLG   +   D+K+H FFR IDW  L  K+++PP+ P   GR +  NFD
Sbjct: 888 MRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFD 947

Query: 631 RFFTRHPPVLTPP-DQEVIRNIDQSEFEGFSFV 662
             FT   P+LTPP +  ++   +Q  F  F ++
Sbjct: 948 DEFTSEAPILTPPREPRILSEEEQEMFRDFDYI 980


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  320 bits (819), Expect = 4e-87
 Identities = 158/370 (42%), Positives = 232/370 (62%), Gaps = 15/370 (4%)

Query: 286 FNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRD---------R 336
           F+V  P E  E  E ++   +R +  +     E    +  S+ DN G  +         R
Sbjct: 87  FHVDTPEEREEWTEAIQAVADRLQRQE----EERMNCSPTSQIDNIGEEEMDASTTHHKR 142

Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396
             + DF++L +LGKG+FGKV+L   K + + YA+KILKK+V+I  D+V  T+ E RVL  
Sbjct: 143 KTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN 202

Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456
             + PFLT L   FQT DRL FVMEYVNGG+L +H+ +   F E    FY AEI   L +
Sbjct: 203 T-RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDY 261

Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516
           L S  I+YRDLKL+N+MLD +GHIKI DFG+CKE I D  T KTFCGTP+Y+APE++   
Sbjct: 262 LHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDN 321

Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 576
            YG++VDWW  GV++YEM+ G+ PF  +D ++LF+ I+  ++ +P+++S +A ++  GL+
Sbjct: 322 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLL 381

Query: 577 TKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRFFTR 635
            K P KRLG GP+  ++I  H+FF  ++W+ +  K++ PP+KP+     +   FD  FT 
Sbjct: 382 IKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTA 441

Query: 636 HPPVLTPPDQ 645
               +TPP++
Sbjct: 442 QTITITPPEK 451


>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  320 bits (819), Expect = 4e-87
 Identities = 158/370 (42%), Positives = 232/370 (62%), Gaps = 15/370 (4%)

Query: 286 FNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRD---------R 336
           F+V  P E  E  E ++   +R +  +     E    +  S+ DN G  +         R
Sbjct: 87  FHVDTPEEREEWTEAIQAVADRLQRQE----EERMNCSPTSQIDNIGEEEMDASTTHHKR 142

Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396
             + DF++L +LGKG+FGKV+L   K + + YA+KILKK+V+I  D+V  T+ E RVL  
Sbjct: 143 KTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN 202

Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456
             + PFLT L   FQT DRL FVMEYVNGG+L +H+ +   F E    FY AEI   L +
Sbjct: 203 T-RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDY 261

Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516
           L S  I+YRDLKL+N+MLD +GHIKI DFG+CKE I D  T KTFCGTP+Y+APE++   
Sbjct: 262 LHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDN 321

Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 576
            YG++VDWW  GV++YEM+ G+ PF  +D ++LF+ I+  ++ +P+++S +A ++  GL+
Sbjct: 322 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLL 381

Query: 577 TKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRFFTR 635
            K P KRLG GP+  ++I  H+FF  ++W+ +  K++ PP+KP+     +   FD  FT 
Sbjct: 382 IKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTA 441

Query: 636 HPPVLTPPDQ 645
               +TPP++
Sbjct: 442 QTITITPPEK 451


>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
          Length = 948

 Score =  319 bits (818), Expect = 5e-87
 Identities = 159/330 (48%), Positives = 216/330 (65%), Gaps = 5/330 (1%)

Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396
           + L DF FL VLG+G FGKV+LSE + + EL+A+K LKK  ++  D+VE  M EKR+LA 
Sbjct: 616 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 675

Query: 397 PGKP--PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454
                 PFL  L  CFQT + + FVMEY  GGDLM HI     F EP A+FY+A + +GL
Sbjct: 676 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGL 734

Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514
            FL    I+YRDLKLDN++LD+EG++KIADFG+CKE +  G  T TFCGTP+++APE++ 
Sbjct: 735 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 794

Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574
              Y ++VDWW  GVLLYEML G++PF G+DE+E+F SI+   V YP+ +S EA+ I + 
Sbjct: 795 DTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRR 854

Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRFF 633
           L+ ++P +RLG       D+K+  FFR + WE L  + + PP+ P   GR +  NFD  F
Sbjct: 855 LLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEF 914

Query: 634 TRHPPVLTPP-DQEVIRNIDQSEFEGFSFV 662
           T   P L+PP D   +   +Q+ F  F FV
Sbjct: 915 TGEAPTLSPPRDARPLTAAEQAAFLDFDFV 944


>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
          Length = 942

 Score =  319 bits (818), Expect = 5e-87
 Identities = 159/330 (48%), Positives = 216/330 (65%), Gaps = 5/330 (1%)

Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396
           + L DF FL VLG+G FGKV+LSE + + EL+A+K LKK  ++  D+VE  M EKR+LA 
Sbjct: 610 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 669

Query: 397 PGKP--PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454
                 PFL  L  CFQT + + FVMEY  GGDLM HI     F EP A+FY+A + +GL
Sbjct: 670 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGL 728

Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514
            FL    I+YRDLKLDN++LD+EG++KIADFG+CKE +  G  T TFCGTP+++APE++ 
Sbjct: 729 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 788

Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574
              Y ++VDWW  GVLLYEML G++PF G+DE+E+F SI+   V YP+ +S EA+ I + 
Sbjct: 789 DTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRR 848

Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRFF 633
           L+ ++P +RLG       D+K+  FFR + WE L  + + PP+ P   GR +  NFD  F
Sbjct: 849 LLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEF 908

Query: 634 TRHPPVLTPP-DQEVIRNIDQSEFEGFSFV 662
           T   P L+PP D   +   +Q+ F  F FV
Sbjct: 909 TGEAPTLSPPRDARPLTAAEQAAFLDFDFV 938


>gi|4502023 AKT2 kinase [Homo sapiens]
          Length = 481

 Score =  316 bits (809), Expect = 5e-86
 Identities = 149/330 (45%), Positives = 218/330 (66%), Gaps = 2/330 (0%)

Query: 317 PEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKD 376
           P + +T    +   +  R ++ + DF++L +LGKG+FGKV+L   K T   YA+KIL+K+
Sbjct: 127 PSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKE 186

Query: 377 VVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG 436
           V+I  D+V  T+ E RVL    + PFLT L   FQT DRL FVMEY NGG+L +H+ +  
Sbjct: 187 VIIAKDEVAHTVTESRVLQNT-RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRER 245

Query: 437 RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV 496
            F E  A FY AEI   L +L S+ ++YRD+KL+N+MLD +GHIKI DFG+CKE I DG 
Sbjct: 246 VFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGA 305

Query: 497 TTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH 556
           T KTFCGTP+Y+APE++    YG++VDWW  GV++YEM+ G+ PF  +D + LF+ I+  
Sbjct: 306 TMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILME 365

Query: 557 NVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPP 616
            + +P+++S EA ++  GL+ K P +RLG GP   +++ EH FF  I+W+ + +K++ PP
Sbjct: 366 EIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPP 425

Query: 617 YKPKACGR-NAENFDRFFTRHPPVLTPPDQ 645
           +KP+     +   FD  FT     +TPPD+
Sbjct: 426 FKPQVTSEVDTRYFDDEFTAQSITITPPDR 455


>gi|62241015 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  315 bits (807), Expect = 9e-86
 Identities = 161/375 (42%), Positives = 233/375 (62%), Gaps = 21/375 (5%)

Query: 286 FNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTN--TVSKFDNNGNRD-------- 335
           F+V  P E  E    ++       ++ G K  EE+  +  + S  DN+G  +        
Sbjct: 88  FHVETPEEREEWTTAIQT------VADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKP 141

Query: 336 --RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393
             R+ + +F +L +LGKG+FGKV+L + K T   YA+KILKK+V++  D+V  T+ E RV
Sbjct: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201

Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453
           L    + PFLT L   FQT DRL FVMEY NGG+L +H+ +   F E  A FY AEI   
Sbjct: 202 LQ-NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260

Query: 454 LFFLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512
           L +L S K ++YRDLKL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE+
Sbjct: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320

Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 572
           +    YG++VDWW  GV++YEM+ G+ PF  +D ++LF+ I+   + +P+++  EA ++ 
Sbjct: 321 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380

Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDR 631
            GL+ K P +RLG G E  ++I +H FF  I W+ +  K++ PP+KP+     +   FD 
Sbjct: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440

Query: 632 FFTRHPPVLTPPDQE 646
            FT     +TPPDQ+
Sbjct: 441 EFTAQMITITPPDQD 455


>gi|62241013 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  315 bits (807), Expect = 9e-86
 Identities = 161/375 (42%), Positives = 233/375 (62%), Gaps = 21/375 (5%)

Query: 286 FNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTN--TVSKFDNNGNRD-------- 335
           F+V  P E  E    ++       ++ G K  EE+  +  + S  DN+G  +        
Sbjct: 88  FHVETPEEREEWTTAIQT------VADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKP 141

Query: 336 --RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393
             R+ + +F +L +LGKG+FGKV+L + K T   YA+KILKK+V++  D+V  T+ E RV
Sbjct: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201

Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453
           L    + PFLT L   FQT DRL FVMEY NGG+L +H+ +   F E  A FY AEI   
Sbjct: 202 LQ-NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260

Query: 454 LFFLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512
           L +L S K ++YRDLKL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE+
Sbjct: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320

Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 572
           +    YG++VDWW  GV++YEM+ G+ PF  +D ++LF+ I+   + +P+++  EA ++ 
Sbjct: 321 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380

Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDR 631
            GL+ K P +RLG G E  ++I +H FF  I W+ +  K++ PP+KP+     +   FD 
Sbjct: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440

Query: 632 FFTRHPPVLTPPDQE 646
            FT     +TPPDQ+
Sbjct: 441 EFTAQMITITPPDQD 455


>gi|62241011 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  315 bits (807), Expect = 9e-86
 Identities = 161/375 (42%), Positives = 233/375 (62%), Gaps = 21/375 (5%)

Query: 286 FNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTN--TVSKFDNNGNRD-------- 335
           F+V  P E  E    ++       ++ G K  EE+  +  + S  DN+G  +        
Sbjct: 88  FHVETPEEREEWTTAIQT------VADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKP 141

Query: 336 --RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393
             R+ + +F +L +LGKG+FGKV+L + K T   YA+KILKK+V++  D+V  T+ E RV
Sbjct: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201

Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453
           L    + PFLT L   FQT DRL FVMEY NGG+L +H+ +   F E  A FY AEI   
Sbjct: 202 LQ-NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260

Query: 454 LFFLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512
           L +L S K ++YRDLKL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE+
Sbjct: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320

Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 572
           +    YG++VDWW  GV++YEM+ G+ PF  +D ++LF+ I+   + +P+++  EA ++ 
Sbjct: 321 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380

Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDR 631
            GL+ K P +RLG G E  ++I +H FF  I W+ +  K++ PP+KP+     +   FD 
Sbjct: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440

Query: 632 FFTRHPPVLTPPDQE 646
            FT     +TPPDQ+
Sbjct: 441 EFTAQMITITPPDQD 455


>gi|40254851 protein kinase PKNbeta [Homo sapiens]
          Length = 889

 Score =  303 bits (777), Expect = 3e-82
 Identities = 157/336 (46%), Positives = 210/336 (62%), Gaps = 5/336 (1%)

Query: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
           +L DF  L VLG+G FGKV+L + KGT + YA+K LKK  V+  D++E    EKR+L   
Sbjct: 555 RLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAV 614

Query: 398 GKP--PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455
           G    PFL  L +CFQT     FV E+V GGDLM  I +   F EP A FY A + +GL 
Sbjct: 615 GCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHE-DVFPEPQARFYVACVVLGLQ 673

Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515
           FL  K IIYRDLKLDN++LD++G +KIADFG+CKE I  G  T TFCGTP+++APE++  
Sbjct: 674 FLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQ 733

Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575
           + Y ++VDWW  GVLLYEML G+ PF G+ E+E+F  I+  +  YP  +S + +   + L
Sbjct: 734 EAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKL 793

Query: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACG-RNAENFDRFFT 634
           + K P KRLG G +   +IK   FFR  +W+ L  + IQPP+ P  CG  +   F+  FT
Sbjct: 794 LQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFT 853

Query: 635 RHPPVLTPP-DQEVIRNIDQSEFEGFSFVNSEFLKP 669
             PP LTPP    ++    Q+ F  F FV+  FL+P
Sbjct: 854 GLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP 889


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  287 bits (735), Expect = 2e-77
 Identities = 141/301 (46%), Positives = 196/301 (65%), Gaps = 2/301 (0%)

Query: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
           K +DF+FL V+GKGSFGKV+L+  K  +  YAVK+L+K  +++  + +  M E+ VL   
Sbjct: 94  KPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKN 153

Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457
            K PFL  LH  FQT D+LYFV++Y+NGG+L YH+Q+   F EP A FYAAEIA  L +L
Sbjct: 154 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 213

Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517
            S  I+YRDLK +N++LDS+GHI + DFG+CKENI    TT TFCGTP+Y+APE++  QP
Sbjct: 214 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 273

Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577
           Y ++VDWW  G +LYEML G  PF   +  E++ +I+   +    +++  A  + +GL+ 
Sbjct: 274 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 333

Query: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRN-AENFDRFFTRH 636
           K   KRLG   +   +IK H FF  I+W+ L  K+I PP+ P   G N   +FD  FT  
Sbjct: 334 KDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 392

Query: 637 P 637
           P
Sbjct: 393 P 393


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  287 bits (735), Expect = 2e-77
 Identities = 141/301 (46%), Positives = 196/301 (65%), Gaps = 2/301 (0%)

Query: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
           K +DF+FL V+GKGSFGKV+L+  K  +  YAVK+L+K  +++  + +  M E+ VL   
Sbjct: 108 KPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKN 167

Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457
            K PFL  LH  FQT D+LYFV++Y+NGG+L YH+Q+   F EP A FYAAEIA  L +L
Sbjct: 168 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 227

Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517
            S  I+YRDLK +N++LDS+GHI + DFG+CKENI    TT TFCGTP+Y+APE++  QP
Sbjct: 228 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 287

Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577
           Y ++VDWW  G +LYEML G  PF   +  E++ +I+   +    +++  A  + +GL+ 
Sbjct: 288 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 347

Query: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRN-AENFDRFFTRH 636
           K   KRLG   +   +IK H FF  I+W+ L  K+I PP+ P   G N   +FD  FT  
Sbjct: 348 KDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 406

Query: 637 P 637
           P
Sbjct: 407 P 407


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  287 bits (735), Expect = 2e-77
 Identities = 141/301 (46%), Positives = 196/301 (65%), Gaps = 2/301 (0%)

Query: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
           K +DF+FL V+GKGSFGKV+L+  K  +  YAVK+L+K  +++  + +  M E+ VL   
Sbjct: 122 KPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKN 181

Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457
            K PFL  LH  FQT D+LYFV++Y+NGG+L YH+Q+   F EP A FYAAEIA  L +L
Sbjct: 182 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 241

Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517
            S  I+YRDLK +N++LDS+GHI + DFG+CKENI    TT TFCGTP+Y+APE++  QP
Sbjct: 242 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 301

Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577
           Y ++VDWW  G +LYEML G  PF   +  E++ +I+   +    +++  A  + +GL+ 
Sbjct: 302 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 361

Query: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRN-AENFDRFFTRH 636
           K   KRLG   +   +IK H FF  I+W+ L  K+I PP+ P   G N   +FD  FT  
Sbjct: 362 KDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 420

Query: 637 P 637
           P
Sbjct: 421 P 421


>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
           [Homo sapiens]
          Length = 526

 Score =  287 bits (735), Expect = 2e-77
 Identities = 141/301 (46%), Positives = 196/301 (65%), Gaps = 2/301 (0%)

Query: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
           K +DF+FL V+GKGSFGKV+L+  K  +  YAVK+L+K  +++  + +  M E+ VL   
Sbjct: 189 KPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKN 248

Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457
            K PFL  LH  FQT D+LYFV++Y+NGG+L YH+Q+   F EP A FYAAEIA  L +L
Sbjct: 249 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 308

Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517
            S  I+YRDLK +N++LDS+GHI + DFG+CKENI    TT TFCGTP+Y+APE++  QP
Sbjct: 309 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 368

Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577
           Y ++VDWW  G +LYEML G  PF   +  E++ +I+   +    +++  A  + +GL+ 
Sbjct: 369 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 428

Query: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRN-AENFDRFFTRH 636
           K   KRLG   +   +IK H FF  I+W+ L  K+I PP+ P   G N   +FD  FT  
Sbjct: 429 KDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 487

Query: 637 P 637
           P
Sbjct: 488 P 488


>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
           [Homo sapiens]
          Length = 427

 Score =  275 bits (702), Expect = 1e-73
 Identities = 145/378 (38%), Positives = 219/378 (57%), Gaps = 12/378 (3%)

Query: 288 VPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMV 347
           +PVPPE  +    +           GT  P+    N       + N +    TDF+FL V
Sbjct: 48  LPVPPELPDHCYRMNSS------PAGTPSPQPSRANGNINLGPSANPNAQP-TDFDFLKV 100

Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407
           +GKG++GKV+L++RK     YAVK+L+K  +++  +    M E+ VL    + PFL  L 
Sbjct: 101 IGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLR 160

Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467
             FQT ++LYFV++YVNGG+L +H+Q+  RF EP A FYAAE+A  + +L S  IIYRDL
Sbjct: 161 YSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDL 220

Query: 468 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAF 527
           K +N++LD +GH+ + DFG+CKE +    TT TFCGTP+Y+APE++  +PY ++VDWW  
Sbjct: 221 KPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCL 280

Query: 528 GVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCG 587
           G +LYEML G  PF  +D  +++++I+   +  P   +  A  + + L+ K   +RLG  
Sbjct: 281 GAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSK 340

Query: 588 PEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACG-RNAENFDRFFTRH---PPVLTPP 643
            +   +IK H FF  I+W+ L  K + PP+ P   G  + ++FD  FT+      +   P
Sbjct: 341 AD-FLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTP 399

Query: 644 DQEVIRNIDQSEFEGFSF 661
           D     +   S F GFS+
Sbjct: 400 DTVASSSGASSAFLGFSY 417


>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
           [Homo sapiens]
          Length = 367

 Score =  273 bits (698), Expect = 4e-73
 Identities = 140/353 (39%), Positives = 211/353 (59%), Gaps = 6/353 (1%)

Query: 313 GTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKI 372
           GT  P+    N       + N +    TDF+FL V+GKG++GKV+L++RK     YAVK+
Sbjct: 7   GTPSPQPSRANGNINLGPSANPNAQP-TDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKV 65

Query: 373 LKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI 432
           L+K  +++  +    M E+ VL    + PFL  L   FQT ++LYFV++YVNGG+L +H+
Sbjct: 66  LQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHL 125

Query: 433 QQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI 492
           Q+  RF EP A FYAAE+A  + +L S  IIYRDLK +N++LD +GH+ + DFG+CKE +
Sbjct: 126 QRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGV 185

Query: 493 WDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQS 552
               TT TFCGTP+Y+APE++  +PY ++VDWW  G +LYEML G  PF  +D  +++++
Sbjct: 186 EPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYEN 245

Query: 553 IMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKE 612
           I+   +  P   +  A  + + L+ K   +RLG   +   +IK H FF  I+W+ L  K 
Sbjct: 246 ILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKAD-FLEIKNHVFFSPINWDDLYHKR 304

Query: 613 IQPPYKPKACG-RNAENFDRFFTRH---PPVLTPPDQEVIRNIDQSEFEGFSF 661
           + PP+ P   G  + ++FD  FT+      +   PD     +   S F GFS+
Sbjct: 305 LTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 357


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  271 bits (693), Expect = 1e-72
 Identities = 139/298 (46%), Positives = 191/298 (64%), Gaps = 2/298 (0%)

Query: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
           K TDF+FL V+GKGSFGKV+L++RK   + YAVK+L+K +V+   + +  M E+ VL   
Sbjct: 158 KPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKN 217

Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457
            K PFL  LH  FQT ++LYFV+++VNGG+L +H+Q+   F E  A FYAAEIA  L +L
Sbjct: 218 VKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYL 277

Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517
            S  I+YRDLK +N++LDS GH+ + DFG+CKE I    TT TFCGTP+Y+APE+I  QP
Sbjct: 278 HSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQP 337

Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577
           Y  +VDWW  G +LYEML G  PF   D  E++ +I+   ++    +S  A +I + L+ 
Sbjct: 338 YDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLE 397

Query: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACG-RNAENFDRFFT 634
           K    RLG   E   +I+ H FF  + W  L +K+I PP+ P   G  +  NFD  FT
Sbjct: 398 KDRQNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFT 454


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,927,011
Number of Sequences: 37866
Number of extensions: 1406031
Number of successful extensions: 8884
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 842
Number of HSP's successfully gapped in prelim test: 406
Number of HSP's that attempted gapping in prelim test: 4950
Number of HSP's gapped (non-prelim): 2943
length of query: 673
length of database: 18,247,518
effective HSP length: 109
effective length of query: 564
effective length of database: 14,120,124
effective search space: 7963749936
effective search space used: 7963749936
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.