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Search of human proteins with 19923983
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
(313 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo... 629 e-180
gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo ... 629 e-180
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens] 72 8e-13
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens] 65 6e-11
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens] 64 1e-10
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 64 2e-10
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 63 3e-10
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 63 3e-10
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 62 9e-10
gi|40254992 carbonic reductase 4 [Homo sapiens] 60 3e-09
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens] 60 3e-09
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 60 3e-09
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 59 6e-09
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens] 59 7e-09
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens] 58 1e-08
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 55 1e-07
gi|223646115 short chain dehydrogenase/reductase family 16C, mem... 54 1e-07
gi|186928839 retinol dehydrogenase 12 [Homo sapiens] 54 1e-07
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 54 1e-07
gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Hom... 52 5e-07
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ... 52 9e-07
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens] 51 1e-06
gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo... 51 1e-06
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform... 51 2e-06
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 50 3e-06
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 49 4e-06
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 49 6e-06
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 49 8e-06
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 49 8e-06
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 49 8e-06
>gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 629 bits (1622), Expect = e-180
Identities = 313/313 (100%), Positives = 313/313 (100%)
Query: 1 MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVP 60
MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVP
Sbjct: 1 MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVP 60
Query: 61 VVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDIN 120
VVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDIN
Sbjct: 61 VVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDIN 120
Query: 121 NVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHE 180
NVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHE
Sbjct: 121 NVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHE 180
Query: 181 LRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCVVALA 240
LRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCVVALA
Sbjct: 181 LRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCVVALA 240
Query: 241 TDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSVLSHVSGLGWLASYLPSFLR 300
TDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSVLSHVSGLGWLASYLPSFLR
Sbjct: 241 TDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSVLSHVSGLGWLASYLPSFLR 300
Query: 301 VPKWIIALYTSKF 313
VPKWIIALYTSKF
Sbjct: 301 VPKWIIALYTSKF 313
>gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 629 bits (1622), Expect = e-180
Identities = 313/313 (100%), Positives = 313/313 (100%)
Query: 1 MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVP 60
MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVP
Sbjct: 1 MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVP 60
Query: 61 VVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDIN 120
VVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDIN
Sbjct: 61 VVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDIN 120
Query: 121 NVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHE 180
NVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHE
Sbjct: 121 NVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHE 180
Query: 181 LRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCVVALA 240
LRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCVVALA
Sbjct: 181 LRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCVVALA 240
Query: 241 TDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSVLSHVSGLGWLASYLPSFLR 300
TDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSVLSHVSGLGWLASYLPSFLR
Sbjct: 241 TDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSVLSHVSGLGWLASYLPSFLR 300
Query: 301 VPKWIIALYTSKF 313
VPKWIIALYTSKF
Sbjct: 301 VPKWIIALYTSKF 313
>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
Length = 418
Score = 71.6 bits (174), Expect = 8e-13
Identities = 57/197 (28%), Positives = 93/197 (47%), Gaps = 19/197 (9%)
Query: 7 GQVCVVTGASRGIGRGIALQLCKAGATVYITGRH-------LDTLRVVAQEAQSLGGQCV 59
G +TGASRGIG+ IAL+ K GA + I + L T+ A+E +++GG+ +
Sbjct: 10 GCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIEAVGGKAL 69
Query: 60 PVVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDI 119
P + D E ++ + E+ + + G +D+LVNNA A ++ NT +TP D +
Sbjct: 70 PCIVDVRDEQQISAAVEKAIK-KFGGIDILVNNASA--ISLTNT-----LDTPTKRLDLM 121
Query: 120 NNVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQ---YMFNVPYGVGKAACDKLAAD 176
NV RG Y S + + I+ IS P +L + + Y + K
Sbjct: 122 MNVNTRGTYLASKACIPYLKKSKVAHILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLG 181
Query: 177 CAHELRRHGVSCVSLWP 193
A E + ++ +LWP
Sbjct: 182 MAEEFKGE-IAVNALWP 197
>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
Length = 261
Score = 65.5 bits (158), Expect = 6e-11
Identities = 61/212 (28%), Positives = 91/212 (42%), Gaps = 24/212 (11%)
Query: 5 MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSL---------- 54
+ + +VTGA GIGR ++++L GATV D R AQE L
Sbjct: 9 LRSALALVTGAGSGIGRAVSVRLAGEGATVAAC----DLDRAAAQETVRLLGGPGSKEGP 64
Query: 55 -GGQCVPVVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPA 113
G D S+ R L EQV V+V+ AG+ T+++
Sbjct: 65 PRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVS--CAGI-----TQDEFLLHMSE 117
Query: 114 SMWDDINNVGLRGHYFCSVYGARLMVPAG-QGLIVVISS-PGSLQYMFNVPYGVGKAACD 171
WD + V L+G + + A+ +V G +G I+ ISS G + + Y KA
Sbjct: 118 DDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVI 177
Query: 172 KLAADCAHELRRHGVSCVSLWPGIVQTELLKE 203
L A EL RHG+ C S+ PG + T + ++
Sbjct: 178 GLTQTAARELGRHGIRCNSVLPGFIATPMTQK 209
>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
Length = 303
Score = 64.3 bits (155), Expect = 1e-10
Identities = 55/206 (26%), Positives = 89/206 (43%), Gaps = 15/206 (7%)
Query: 5 MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQ-----SLGGQCV 59
+ GQV +VTG + GIG+ I +L + G+ V I R L+ L+ A E Q + + +
Sbjct: 16 LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
Query: 60 PVVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDI 119
P+ C+ E EV +L + + G+++ LVNN G Q + + + W +
Sbjct: 76 PIQCNIRNEEEVNNLVKST-LDTFGKINFLVNN--GGGQFLSPAEH-----ISSKGWHAV 127
Query: 120 NNVGLRG-HYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCA 178
L G Y C + M G G IV I P + V G +A L A
Sbjct: 128 LETNLTGTFYMCKAVYSSWMKEHG-GSIVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLA 186
Query: 179 HELRRHGVSCVSLWPGIVQTELLKEH 204
E G+ + PG++ ++ E+
Sbjct: 187 LEWACSGIRINCVAPGVIYSQTAVEN 212
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 63.5 bits (153), Expect = 2e-10
Identities = 65/212 (30%), Positives = 98/212 (46%), Gaps = 22/212 (10%)
Query: 7 GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCDSS 66
G+V VVTG RGIG GI +GA V I + R + QE V ++CD +
Sbjct: 9 GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPG----AVFILCDVT 64
Query: 67 QESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLRG 126
QE +V++L + R + GRLD +VNNA + + ET A + + + L G
Sbjct: 65 QEDDVKTLVSETIR-RFGRLDCVVNNAGH------HPPPQRPEETSAQGFRQLLELNLLG 117
Query: 127 HYFCSVYGARLMVP---AGQGLIVVISS-PGSLQYMFNVPYGVGKAACDKLAADCAHELR 182
Y + +L +P QG ++ ISS G++ VPY K A + A +
Sbjct: 118 TYTLT----KLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDES 173
Query: 183 RHGVSCVSLWPGIVQTELLKEHMAKEEVLQDP 214
+GV + PG + T L +E A ++ DP
Sbjct: 174 PYGVRVNCISPGNIWTPLWEELAA---LMPDP 202
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 63.2 bits (152), Expect = 3e-10
Identities = 57/198 (28%), Positives = 83/198 (41%), Gaps = 11/198 (5%)
Query: 5 MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCD 64
+ G+ +VTGAS+GIGR +A L K GA V +T R +TL+ V LG +
Sbjct: 32 LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAG 91
Query: 65 SSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGL 124
+ ++ F + G LD+L+ N T LN + SM ++N +
Sbjct: 92 TMEDMTFAEQFVAQAGKLMGGLDMLILNHI--TNTSLNLFHDDIHHVRKSM--EVNFLS- 146
Query: 125 RGHYFCSVYGARLMVPAGQGLIVVISS-PGSLQYMFNVPYGVGKAACDKLAADCAHE--L 181
Y A M+ G IVV+SS G + Y Y K A D + E +
Sbjct: 147 ---YVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV 203
Query: 182 RRHGVSCVSLWPGIVQTE 199
R VS G++ TE
Sbjct: 204 SRVNVSITLCVLGLIDTE 221
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 63.2 bits (152), Expect = 3e-10
Identities = 57/198 (28%), Positives = 83/198 (41%), Gaps = 11/198 (5%)
Query: 5 MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCD 64
+ G+ +VTGAS+GIGR +A L K GA V +T R +TL+ V LG +
Sbjct: 32 LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAG 91
Query: 65 SSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGL 124
+ ++ F + G LD+L+ N T LN + SM ++N +
Sbjct: 92 TMEDMTFAEQFVAQAGKLMGGLDMLILNHI--TNTSLNLFHDDIHHVRKSM--EVNFLS- 146
Query: 125 RGHYFCSVYGARLMVPAGQGLIVVISS-PGSLQYMFNVPYGVGKAACDKLAADCAHE--L 181
Y A M+ G IVV+SS G + Y Y K A D + E +
Sbjct: 147 ---YVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV 203
Query: 182 RRHGVSCVSLWPGIVQTE 199
R VS G++ TE
Sbjct: 204 SRVNVSITLCVLGLIDTE 221
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 61.6 bits (148), Expect = 9e-10
Identities = 59/204 (28%), Positives = 89/204 (43%), Gaps = 23/204 (11%)
Query: 8 QVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLG--GQCVPVVCDS 65
++ +VTGAS GIG +A L + G V R + + +A E +S G G +P CD
Sbjct: 12 RLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDL 71
Query: 66 SQESEVRSLFEQVDREQQGRLDVLVNNA-YAGVQTILNTRNKAFWETPASMWDDINNVGL 124
S E ++ S+F + R Q +D+ +NNA A T+L+ S W D+ NV +
Sbjct: 72 SNEEDILSMFSAI-RSQHSGVDICINNAGLARPDTLLS--------GSTSGWKDMFNVNV 122
Query: 125 RGHYFCS--VYGARLMVPAGQGLIVVISSPGS---LQYMFNVPYGVGKAACDKLAADCAH 179
C+ Y + G I+ I+S L Y K A L
Sbjct: 123 LALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQ 182
Query: 180 ELRRH----GVSCVSLWPGIVQTE 199
ELR +C+S PG+V+T+
Sbjct: 183 ELREAQTHIRATCIS--PGVVETQ 204
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 59.7 bits (143), Expect = 3e-09
Identities = 54/205 (26%), Positives = 91/205 (44%), Gaps = 12/205 (5%)
Query: 8 QVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCDSSQ 67
+VC V G SRGIGR +A + + G + + R+L+ + A + LGG + CD ++
Sbjct: 3 KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGD---LGGDHLAFSCDVAK 59
Query: 68 ESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLRGH 127
E +V++ FE++++ GR++ LVN A +L R K M ++ L
Sbjct: 60 EHDVQNTFEELEK-HLGRVNFLVNAAGINRDGLL-VRTKT-----EDMVSQLHTNLLGSM 112
Query: 128 YFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHELRRHGVS 187
C ++ G ++ V S G Y K + A E+ R +
Sbjct: 113 LTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIR 172
Query: 188 CVSLWPGIVQTELLKEHMAKEEVLQ 212
+ PG V T++ K+ KEE L+
Sbjct: 173 VNVVAPGFVHTDMTKD--LKEEHLK 195
>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
Length = 245
Score = 59.7 bits (143), Expect = 3e-09
Identities = 66/245 (26%), Positives = 111/245 (45%), Gaps = 28/245 (11%)
Query: 5 MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCD 64
++G+V ++T A++GIG+ AL + GA V T D QE + G V+ D
Sbjct: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIAT----DINESKLQELEKYPGIQTRVL-D 58
Query: 65 SSQESEVRSLFEQVDREQQGRLDVLVNNA-YAGVQTILNTRNKAFWETPASMWDDINNVG 123
+++ ++ +V+ RLDVL N A + T+L+ K WD N+
Sbjct: 59 VTKKKQIDQFANEVE-----RLDVLFNVAGFVHHGTVLDCEEKD--------WDFSMNLN 105
Query: 124 LRGHY-FCSVYGARLMVPAGQGLIVVISSPGSLQYMFN-VPYGVGKAACDKLAADCAHEL 181
+R Y + +++ +I + S S++ + N Y KAA L A +
Sbjct: 106 VRSMYLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADF 165
Query: 182 RRHGVSCVSLWPGIVQTELLKEHMA----KEEVLQDPVLKQFKSAFSSAETTELSGKCVV 237
+ G+ C + PG V T L+E + EE D + +Q F++AE E++ CV
Sbjct: 166 IQQGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAE--EIAMLCVY 223
Query: 238 ALATD 242
LA+D
Sbjct: 224 -LASD 227
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 59.7 bits (143), Expect = 3e-09
Identities = 60/211 (28%), Positives = 97/211 (45%), Gaps = 25/211 (11%)
Query: 7 GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGG--QCVPVVCD 64
G+V VVTGA+ GIG+ A +L + GA VY+ R ++ +VA+E Q+ G Q + D
Sbjct: 41 GKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLD 100
Query: 65 SSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGL 124
S +R+ F + ++ L VL+NN AGV ++ +E M +N++
Sbjct: 101 LSDTKSIRA-FAKGFLAEEKHLHVLINN--AGVMMCPYSKTADGFE----MHIGVNHL-- 151
Query: 125 RGHYFCSVYGARLMVPAGQGLIVVISS-------------PGSLQYMFNVPYGVGKAACD 171
GH+ + + + IV +SS G Y + Y K A
Sbjct: 152 -GHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANI 210
Query: 172 KLAADCAHELRRHGVSCVSLWPGIVQTELLK 202
+ A L+ GV+ S+ PG VQ+EL++
Sbjct: 211 LFTQELARRLKGSGVTTYSVHPGTVQSELVR 241
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 58.9 bits (141), Expect = 6e-09
Identities = 65/211 (30%), Positives = 97/211 (45%), Gaps = 21/211 (9%)
Query: 5 MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLD--TLRVVAQEAQSLGGQCVPVV 62
+NG+V +VTGA++GIGR A L GA V + +L+ A + Q + + +
Sbjct: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
Query: 63 CDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNV 122
CD + + ++R F +V + GRLD+LVNNA N+ WE IN V
Sbjct: 63 CDVADQQQLRDTFRKV-VDHFGRLDILVNNA--------GVNNEKNWEKTL----QINLV 109
Query: 123 G-LRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVP-YGVGKAACDKL--AADCA 178
+ G Y Y ++ G G+I+ +SS L + P Y K +A A
Sbjct: 110 SVISGTYLGLDYMSKQNGGEG-GIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALA 168
Query: 179 HELRRHGVSCVSLWPGIVQTELLKEHMAKEE 209
L GV ++ PG V T +L E + KEE
Sbjct: 169 ANLMNSGVRLNAICPGFVNTAIL-ESIEKEE 198
>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
Length = 736
Score = 58.5 bits (140), Expect = 7e-09
Identities = 60/207 (28%), Positives = 92/207 (44%), Gaps = 27/207 (13%)
Query: 1 MAAPM--NGQVCVVTGASRGIGRGIALQLCKAGATVYI---------TGRHLDTLRVVAQ 49
M +P+ +G+V +VTGA G+GR AL + GA V + G+ V +
Sbjct: 1 MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVE 60
Query: 50 EAQSLGGQCVPVVCDSSQESE--VRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKA 107
E + GG+ V DS +E E V++ + GR+DV+VNN AG+ R+++
Sbjct: 61 EIRRRGGKAV-ANYDSVEEGEKVVKTALDAF-----GRIDVVVNN--AGI-----LRDRS 107
Query: 108 FWETPASMWDDINNVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMF-NVPYGVG 166
F WD I+ V LRG + + M G I++ SS + F Y
Sbjct: 108 FARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAA 167
Query: 167 KAACDKLAADCAHELRRHGVSCVSLWP 193
K LA A E R+ + C ++ P
Sbjct: 168 KLGLLGLANSLAIEGRKSNIHCNTIAP 194
>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
Length = 335
Score = 57.8 bits (138), Expect = 1e-08
Identities = 46/199 (23%), Positives = 89/199 (44%), Gaps = 17/199 (8%)
Query: 7 GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVV-CDS 65
G+V +TG G+G+G+ L GA I R +D L+ A++ S G V + CD
Sbjct: 59 GKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDV 118
Query: 66 SQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLR 125
V++ ++ + G ++++NNA + + W+T I ++ L
Sbjct: 119 RDPDMVQNTVSELIK-VAGHPNIVINNAAGNFISPTERLSPNAWKT-------ITDIVLN 170
Query: 126 GHYFCSVYGARLMVPAGQG-----LIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHE 180
G F ++ + ++ A +G + + + GS F VP KA + ++ A E
Sbjct: 171 GTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGS---GFVVPSASAKAGVEAMSKSLAAE 227
Query: 181 LRRHGVSCVSLWPGIVQTE 199
++G+ + PG ++T+
Sbjct: 228 WGKYGMRFNVIQPGPIKTK 246
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 54.7 bits (130), Expect = 1e-07
Identities = 52/214 (24%), Positives = 89/214 (41%), Gaps = 11/214 (5%)
Query: 4 PMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVC 63
P+ +V +VT ++ GIG IA +L + GA V ++ R + Q G VC
Sbjct: 29 PLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVC 88
Query: 64 DSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVG 123
+ +E R + G +D+LV+NA +N + + +WD ++
Sbjct: 89 HVGK-AEDRERLVATAVKLHGGIDILVSNA------AVNPFFGSIMDVTEEVWDKTLDIN 141
Query: 124 LRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNV-PYGVGKAACDKLAADCAHELR 182
++ + M G G +V++SS + PY V K A L A EL
Sbjct: 142 VKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELA 201
Query: 183 RHGVSCVSLWPGIVQT---ELLKEHMAKEEVLQD 213
+ L PG+++T +L KEE +++
Sbjct: 202 PRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKE 235
>gi|223646115 short chain dehydrogenase/reductase family 16C, member
6 [Homo sapiens]
Length = 323
Score = 54.3 bits (129), Expect = 1e-07
Identities = 56/224 (25%), Positives = 95/224 (42%), Gaps = 21/224 (9%)
Query: 7 GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCV-PVVCDS 65
G++ + TGA G+GR +A+ + GA + + + + + A+ GG+ V P CD
Sbjct: 36 GEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDC 95
Query: 66 SQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLR 125
S EV + +QV R++ G + +LVNNA K F + P M + V
Sbjct: 96 SNRQEVYRVADQV-RKEFGDVTILVNNADL-------VTGKPFLDIPDHMVEKSFLVNAI 147
Query: 126 GHYFCSVYGARLMVPAGQGLIVVISSPGSL--------QYMFNVPYGVGKAACDKLAADC 177
H++ ++ A G +V ISS + +Y + Y K A A
Sbjct: 148 THFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESL 207
Query: 178 AHEL---RRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQ 218
EL ++ V + P + T + + +K L P+L+Q
Sbjct: 208 FFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLL-PILEQ 250
>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
Length = 316
Score = 54.3 bits (129), Expect = 1e-07
Identities = 72/267 (26%), Positives = 118/267 (44%), Gaps = 37/267 (13%)
Query: 7 GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQE--AQSLGGQCVPVVCD 64
G+V V+TGA+ GIG+ A +L GA VYI R + A E + Q + D
Sbjct: 39 GKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLD 98
Query: 65 SSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGL 124
S +R+ E E++ +L +L+NN AGV ++ +ET +N++
Sbjct: 99 LSDTKSIRAFAEGFLAEEK-QLHILINN--AGVMMCPYSKTADGFETHLG----VNHL-- 149
Query: 125 RGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVP---------YGVGKAAC-DKLA 174
GH+ + + + +V +SS ++ +P Y G A C KLA
Sbjct: 150 -GHFLLTYLLLERLKVSAPARVVNVSSVA--HHIGKIPFHDLQSEKRYSRGFAYCHSKLA 206
Query: 175 -----ADCAHELRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETT 229
+ A L+ GV+ ++ PG+V++EL++ H + +L K+A A+T
Sbjct: 207 NVLFTRELAKRLQGTGVTTYAVHPGVVRSELVR-HSSLLCLLWRLFSPFVKTAREGAQT- 264
Query: 230 ELSGKCVVALATDPNILSLSGKVLPSC 256
S C +A +P LSGK C
Sbjct: 265 --SLHCALAEGLEP----LSGKYFSDC 285
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 54.3 bits (129), Expect = 1e-07
Identities = 41/150 (27%), Positives = 71/150 (47%), Gaps = 9/150 (6%)
Query: 7 GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCV-PVVCDS 65
G++ ++TGA G+GR +ALQ + G+ + + + + + A+ G V CD
Sbjct: 40 GEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDC 99
Query: 66 SQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLR 125
SQ+ V + +QV +E G + +L+NN AG+ T K F + P + + +V +
Sbjct: 100 SQKEGVYRVADQVKKE-VGDVSILINN--AGIVT-----GKKFLDCPDELMEKSFDVNFK 151
Query: 126 GHYFCSVYGARLMVPAGQGLIVVISSPGSL 155
H + M+ G +V ISS L
Sbjct: 152 AHLWTYKAFLPAMIANDHGHLVCISSSAGL 181
>gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Homo
sapiens]
Length = 377
Score = 52.4 bits (124), Expect = 5e-07
Identities = 56/222 (25%), Positives = 96/222 (43%), Gaps = 37/222 (16%)
Query: 5 MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGG--QCVPVV 62
+ G+ VVTGA+ GIG+ AL+L + GA V + R + A + + G + + +
Sbjct: 34 LRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMA 93
Query: 63 CDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNV 122
D + + VR+ F + RLD+L++N AG+ + TR +AF N+
Sbjct: 94 LDLASLASVRA-FATAFLSSEPRLDILIHN--AGISSCGRTR-EAF------------NL 137
Query: 123 GLRGHYFCSVYGARLMVP----AGQGLIVVISSPGSLQYMFNV---------------PY 163
LR ++ L++P +VV++S + + Y
Sbjct: 138 LLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAY 197
Query: 164 GVGKAACDKLAADCAHELRRHGVSCVSLWPGIVQTELLKEHM 205
K A A + A++L GV+C + PG V +EL H+
Sbjct: 198 ADTKLANVLFARELANQLEATGVTCYAAHPGPVNSELFLRHV 239
>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
sapiens]
Length = 302
Score = 51.6 bits (122), Expect = 9e-07
Identities = 29/84 (34%), Positives = 46/84 (54%), Gaps = 2/84 (2%)
Query: 11 VVTGASRGIGRGIALQLCKAGA-TVYITGRHLDTLRVVAQEAQSLGGQCVPVVCDSSQES 69
++TG RGIGR +A + + GA + + GR L+ +E + +G +C +CD
Sbjct: 42 LITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNRE 101
Query: 70 EVRSLFEQVDREQQGRLDVLVNNA 93
EV + V RE+ G + +LVNNA
Sbjct: 102 EVYQTAKAV-REKVGDITILVNNA 124
>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
Length = 244
Score = 51.2 bits (121), Expect = 1e-06
Identities = 60/197 (30%), Positives = 84/197 (42%), Gaps = 20/197 (10%)
Query: 7 GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCDSS 66
G+ +VTGA +GIGRG L GA V R L + +E + CV + +
Sbjct: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEA 66
Query: 67 QESEVRSLFEQVDREQQGRLDVLVNN-AYAGVQTILNTRNKAFWETPASMWDDINNVGLR 125
E + S+ G +D+LVNN A A +Q L +AF D V LR
Sbjct: 67 TERALGSV---------GPVDLLVNNAAVALLQPFLEVTKEAF--------DRSFEVNLR 109
Query: 126 GHYFCSVYGARLMVPAG-QGLIVVISSPGSLQYMFN-VPYGVGKAACDKLAADCAHELRR 183
S AR ++ G G IV +SS S + + N Y K A D L A EL
Sbjct: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169
Query: 184 HGVSCVSLWPGIVQTEL 200
H + ++ P +V T +
Sbjct: 170 HKIRVNAVNPTVVMTSM 186
>gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo
sapiens]
Length = 336
Score = 51.2 bits (121), Expect = 1e-06
Identities = 72/281 (25%), Positives = 119/281 (42%), Gaps = 44/281 (15%)
Query: 5 MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRH-------LDTLRVVAQEAQSLG-- 55
M+G+ ++TGA+ G+GR A +L + GA V + R LR ++A G
Sbjct: 41 MHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPE 100
Query: 56 ------GQCVPVVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFW 109
G+ + D + VR+ +++ +E+ RLDVL+NNA + T
Sbjct: 101 PGVSGVGELIVRELDLASLRSVRAFCQEMLQEEP-RLDVLINNAGIFQCPYMKT------ 153
Query: 110 ETPASMWDDINNVGLRGHYFCSVYGARLMVPAGQGLIVVISSP----GSLQY-MFNVPYG 164
E M +N++ GH+ + L+ + IVV+SS G + + N
Sbjct: 154 EDGFEMQFGVNHL---GHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQS 210
Query: 165 VGKAAC---DKLA-----ADCAHELRRHGVSCVSLWPGIVQTELLKE-HMAKEEVLQDPV 215
K+ C KLA + A L V+ L PGIV+T L + H+ +L P+
Sbjct: 211 YNKSFCYSRSKLANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHI---PLLVKPL 267
Query: 216 LKQFKSAFSSAETTELSGKCVVALATDPNILSLSGKVLPSC 256
AF +T + + LA+ P + +SG+ C
Sbjct: 268 FNLVSWAF--FKTPVEGAQTSIYLASSPEVEGVSGRYFGDC 306
>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform
2 [Homo sapiens]
Length = 178
Score = 50.8 bits (120), Expect = 2e-06
Identities = 33/91 (36%), Positives = 52/91 (57%), Gaps = 3/91 (3%)
Query: 5 MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLD--TLRVVAQEAQSLGGQCVPVV 62
+NG+V +VTGA++GIGR A L GA V + +L+ A + Q + + +
Sbjct: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
Query: 63 CDSSQESEVRSLFEQVDREQQGRLDVLVNNA 93
CD + + ++R F +V + GRLD+LVNNA
Sbjct: 63 CDVADQQQLRDTFRKV-VDHFGRLDILVNNA 92
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 50.1 bits (118), Expect = 3e-06
Identities = 58/247 (23%), Positives = 110/247 (44%), Gaps = 17/247 (6%)
Query: 8 QVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCDSSQ 67
+V VVTG++ GIG IA +L + GA V I+ R + + Q G +VC +
Sbjct: 37 RVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGK 96
Query: 68 ESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLRGH 127
+ L + E G +D LV AGV ++ + T +WD I +V ++
Sbjct: 97 AEDREQLVAKA-LEHCGGVDFLV--CSAGVNPLVGST----LGTSEQIWDKILSVNVKSP 149
Query: 128 YFCSVYGARLM--VPAGQGLIVVISSPGSLQYMFNV-PYGVGKAACDKLAADCAHELRRH 184
++ ++L+ + +G ++++SS + + + Y V K A L A EL
Sbjct: 150 ---ALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPK 206
Query: 185 GVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCVVALATDPN 244
+ + PGI++T+ K E + ++ K+ E+ + +G +V+ P+
Sbjct: 207 DIRVNCVVPGIIKTDFSKVFHGNESLWKN--FKEHHQLQRIGESEDCAG--IVSFLCSPD 262
Query: 245 ILSLSGK 251
++G+
Sbjct: 263 ASYVNGE 269
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 49.3 bits (116), Expect = 4e-06
Identities = 51/207 (24%), Positives = 86/207 (41%), Gaps = 22/207 (10%)
Query: 5 MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCD 64
+ G++ ++TGA GIGR A + K + + + + L A + + LG + V D
Sbjct: 34 VTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVD 93
Query: 65 SSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGL 124
S ++ S ++V + + G + +LVNN AGV + T + V +
Sbjct: 94 CSNREDIYSSAKKV-KAEIGDVSILVNN--AGV-----VYTSDLFATQDPQIEKTFEVNV 145
Query: 125 RGHYFCSVYGARLMVPAGQG-LIVVISSPGSLQYMFNVPY--------GVGKAACDKLAA 175
H++ + M G ++ V S+ G + F + Y G K D+LAA
Sbjct: 146 LAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAA 205
Query: 176 DCAHELRRHGVSCVSLWPGIVQTELLK 202
L+ GV L P V T +K
Sbjct: 206 -----LQITGVKTTCLCPNFVNTGFIK 227
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 48.9 bits (115), Expect = 6e-06
Identities = 57/198 (28%), Positives = 95/198 (47%), Gaps = 24/198 (12%)
Query: 7 GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQ--SLGGQCVPVVC- 63
G VVTG S GIG+ IA++ K GA + + R+ D L +E + S+ + V V+C
Sbjct: 32 GAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQV-VLCI 90
Query: 64 --DSSQE-SEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDIN 120
D SQ+ ++V ++ +Q +E+ G +D+LVN A V + F + S ++ +
Sbjct: 91 SVDVSQDYNQVENVIKQA-QEKLGPVDMLVNCAGMAV-------SGKFEDLEVSTFERLM 142
Query: 121 NVGLRGHYFCSVYGARLMVPAGQ----GLIVVISS-PGSLQYMFNVPYGVGKAACDKLAA 175
++ +Y SVY +R ++ + G IV +SS G L Y K A LA
Sbjct: 143 SI----NYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAE 198
Query: 176 DCAHELRRHGVSCVSLWP 193
E++ + V +P
Sbjct: 199 ALQMEVKPYNVYITVAYP 216
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 48.5 bits (114), Expect = 8e-06
Identities = 51/198 (25%), Positives = 90/198 (45%), Gaps = 13/198 (6%)
Query: 8 QVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCDSSQ 67
+V VVTG++ GIG IA +L + GA V I+ R + + Q G +VC +
Sbjct: 37 RVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGK 96
Query: 68 ESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLRGH 127
+ L + E G +D LV AGV ++ + T +WD I +V ++
Sbjct: 97 AEDREQLVAKA-LEHCGGVDFLV--CSAGVNPLVGST----LGTSEQIWDKILSVNVKSP 149
Query: 128 YFCSVYGARLM--VPAGQGLIVVISSPGSLQYMFNV-PYGVGKAACDKLAADCAHELRRH 184
++ ++L+ + +G ++++SS + + + Y V K A L A EL
Sbjct: 150 ---ALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPK 206
Query: 185 GVSCVSLWPGIVQTELLK 202
+ + PGI++T+ K
Sbjct: 207 DIRVNCVVPGIIKTDFSK 224
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 48.5 bits (114), Expect = 8e-06
Identities = 48/214 (22%), Positives = 93/214 (43%), Gaps = 26/214 (12%)
Query: 3 APMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQE--AQSLGGQCVP 60
A + G+ +VTGA+ GIG+ AL+L + G + + R ++ A++ ++L
Sbjct: 34 ATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNA 93
Query: 61 VVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDIN 120
D + +R ++ E++ R+D+L+NNA GV + + +E M +N
Sbjct: 94 RHLDLASLKSIREFAAKIIEEEE-RVDILINNA--GVMRCPHWTTEDGFE----MQFGVN 146
Query: 121 NVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSL--------------QYMFNVPYGVG 166
++G H+ + + + I+ +SS + +Y Y
Sbjct: 147 HLG---HFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQS 203
Query: 167 KAACDKLAADCAHELRRHGVSCVSLWPGIVQTEL 200
K A + + L+ GV+ +L PG+ +TEL
Sbjct: 204 KLAIVLFTKELSRRLQGSGVTVNALHPGVARTEL 237
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 48.5 bits (114), Expect = 8e-06
Identities = 63/263 (23%), Positives = 107/263 (40%), Gaps = 42/263 (15%)
Query: 3 APMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVP-- 60
A + V V+TGA+ G+G+ A AGA + + GR+ L + +E + V
Sbjct: 48 AYLRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTH 107
Query: 61 ----VVCDSSQESEVRSLFEQVDREQQGRLDVLVNNA---YAGVQTILNTRNKAFWETPA 113
V D + + + ++ + G +D+LVNNA Y G TI++T
Sbjct: 108 KPYLVTFDLTDSGAIVAAAAEI-LQCFGYVDILVNNAGISYRG--TIMDTT--------- 155
Query: 114 SMWDDINNVGLRGHYFCSVYGARLMVPA----GQGLIVVISS-PGSLQYMFNVPYGVGKA 168
D++ + +YF V + ++P+ QG IV ISS G + F Y K
Sbjct: 156 ---VDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKH 212
Query: 169 ACDKLAADCAHELRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAET 228
A E+ ++ + + PG + T L + + S + +T
Sbjct: 213 ATQAFFDCLRAEMEQYEIEVTVISPGYIHTNLSVNAITAD-----------GSRYGVMDT 261
Query: 229 TELSGKCVVALATDPNILSLSGK 251
T G+ V +A D +L+ GK
Sbjct: 262 TTAQGRSPVEVAQD--VLAAVGK 282
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,574,671
Number of Sequences: 37866
Number of extensions: 488669
Number of successful extensions: 1256
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 1171
Number of HSP's gapped (non-prelim): 76
length of query: 313
length of database: 18,247,518
effective HSP length: 102
effective length of query: 211
effective length of database: 14,385,186
effective search space: 3035274246
effective search space used: 3035274246
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.