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Search of human proteins with 19923723
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19923723 ribosomal protein S6 kinase, 52kDa, polypeptide 1
isoform a [Homo sapiens]
(1066 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19923723 ribosomal protein S6 kinase, 52kDa, polypeptide 1 is... 2119 0.0
gi|209915591 ribosomal protein S6 kinase, 52kDa, polypeptide 1 i... 2087 0.0
gi|13899309 ribosomal protein S6 kinase-like 1 [Homo sapiens] 209 9e-54
gi|22547191 sorting nexin 15 isoform A [Homo sapiens] 201 3e-51
gi|46370089 sorting nexin 15 isoform B [Homo sapiens] 163 9e-40
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 126 1e-28
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 126 1e-28
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 122 1e-27
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 114 4e-25
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 114 4e-25
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 113 1e-24
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 112 1e-24
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 106 1e-22
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 104 4e-22
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 104 4e-22
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 104 5e-22
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 99 2e-20
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s... 99 2e-20
gi|112363080 microtubule associated serine/threonine kinase 2 [H... 97 6e-20
gi|5453974 protein kinase N2 [Homo sapiens] 96 1e-19
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 96 2e-19
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 96 2e-19
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 96 2e-19
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 96 2e-19
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 96 2e-19
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 96 2e-19
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 96 2e-19
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 96 2e-19
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 96 2e-19
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 95 3e-19
>gi|19923723 ribosomal protein S6 kinase, 52kDa, polypeptide 1 isoform
a [Homo sapiens]
Length = 1066
Score = 2119 bits (5490), Expect = 0.0
Identities = 1066/1066 (100%), Positives = 1066/1066 (100%)
Query: 1 MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKL 60
MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKL
Sbjct: 1 MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKL 60
Query: 61 HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ 120
HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ
Sbjct: 61 HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ 120
Query: 121 LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD 180
LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD
Sbjct: 121 LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD 180
Query: 181 GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL 240
GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL
Sbjct: 181 GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL 240
Query: 241 EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA 300
EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA
Sbjct: 241 EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA 300
Query: 301 ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT 360
ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT
Sbjct: 301 ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT 360
Query: 361 FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL 420
FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL
Sbjct: 361 FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL 420
Query: 421 NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS 480
NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS
Sbjct: 421 NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS 480
Query: 481 QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN 540
QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN
Sbjct: 481 QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN 540
Query: 541 GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF 600
GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF
Sbjct: 541 GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF 600
Query: 601 FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI 660
FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI
Sbjct: 601 FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI 660
Query: 661 SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI 720
SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI
Sbjct: 661 SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI 720
Query: 721 IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA 780
IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA
Sbjct: 721 IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA 780
Query: 781 VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT 840
VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT
Sbjct: 781 VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT 840
Query: 841 EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY 900
EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY
Sbjct: 841 EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY 900
Query: 901 IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS 960
IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS
Sbjct: 901 IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS 960
Query: 961 DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV 1020
DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV
Sbjct: 961 DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV 1020
Query: 1021 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR
Sbjct: 1021 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
>gi|209915591 ribosomal protein S6 kinase, 52kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 1054
Score = 2087 bits (5407), Expect = 0.0
Identities = 1054/1066 (98%), Positives = 1054/1066 (98%), Gaps = 12/1066 (1%)
Query: 1 MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKL 60
MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTAR IIVWKRYSDFKKL
Sbjct: 1 MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTAR------------IIVWKRYSDFKKL 48
Query: 61 HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ 120
HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ
Sbjct: 49 HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ 108
Query: 121 LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD 180
LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD
Sbjct: 109 LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD 168
Query: 181 GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL 240
GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL
Sbjct: 169 GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL 228
Query: 241 EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA 300
EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA
Sbjct: 229 EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA 288
Query: 301 ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT 360
ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT
Sbjct: 289 ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT 348
Query: 361 FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL 420
FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL
Sbjct: 349 FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL 408
Query: 421 NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS 480
NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS
Sbjct: 409 NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS 468
Query: 481 QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN 540
QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN
Sbjct: 469 QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN 528
Query: 541 GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF 600
GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF
Sbjct: 529 GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF 588
Query: 601 FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI 660
FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI
Sbjct: 589 FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI 648
Query: 661 SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI 720
SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI
Sbjct: 649 SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI 708
Query: 721 IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA 780
IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA
Sbjct: 709 IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA 768
Query: 781 VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT 840
VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT
Sbjct: 769 VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT 828
Query: 841 EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY 900
EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY
Sbjct: 829 EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY 888
Query: 901 IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS 960
IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS
Sbjct: 889 IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS 948
Query: 961 DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV 1020
DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV
Sbjct: 949 DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV 1008
Query: 1021 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR
Sbjct: 1009 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1054
>gi|13899309 ribosomal protein S6 kinase-like 1 [Homo sapiens]
Length = 541
Score = 209 bits (533), Expect = 9e-54
Identities = 91/165 (55%), Positives = 125/165 (75%)
Query: 901 IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS 960
+ E +++WAAEM+VAL+ALH +G++CRDL+P N+LL+ GHI+LTYF +WSEVE C
Sbjct: 353 VREEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLLDQAGHIRLTYFGQWSEVEPQCCG 412
Query: 961 DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV 1020
+A++ +Y APEVG I+E TEACDWWS G++L+ELLTG L + HP+GI HT L +PE +
Sbjct: 413 EAVDNLYSAPEVGGISELTEACDWWSFGSLLYELLTGMALSQSHPSGIQAHTQLQLPEWL 472
Query: 1021 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELM 1065
S A SL+ +LLQF P RLG G GV +KSHPFF+ + W++L+
Sbjct: 473 SRPAASLLTELLQFEPTRRLGMGEGGVSKLKSHPFFSTIQWSKLV 517
Score = 121 bits (303), Expect = 4e-27
Identities = 73/185 (39%), Positives = 102/185 (55%), Gaps = 28/185 (15%)
Query: 232 PKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKR 291
P + KRDYL A I+LAL+++ +DYEAA + Y+ GVD+LL G+ + + RREAVK
Sbjct: 42 PDMTKRDYLVDAATQIRLALERDVSEDYEAAFNHYQNGVDVLLRGIHVDPNKERREAVKL 101
Query: 292 RTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLL 351
+ +YL RAE I + + RPL + SP+ V L
Sbjct: 102 KITKYLRRAEEIFNCH---------------LQRPLSSGASPS-------------AVQL 133
Query: 352 VMDTRTEQTFILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGK 411
V D T TF++K L + SR R TIIP VP M L +Y +SE+S+FL L+H +GG
Sbjct: 134 VQDPATGGTFVVKSLPRCHMVSRERLTIIPHGVPYMTKLLRYFVSEDSIFLHLEHVQGGT 193
Query: 412 LWSYI 416
LWS++
Sbjct: 194 LWSHL 198
>gi|22547191 sorting nexin 15 isoform A [Homo sapiens]
Length = 342
Score = 201 bits (511), Expect = 3e-51
Identities = 129/334 (38%), Positives = 178/334 (53%), Gaps = 31/334 (9%)
Query: 5 RERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKEL 64
R+ D R YTV++P+ HP+GYT YKVTA+ +S+++PEDV+E++VWKRYSDF+KLH +L
Sbjct: 3 RQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDVKEVVVWKRYSDFRKLHGDL 62
Query: 65 WQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDF 124
H+NLFR E FP F + VFGRF+ +VIEERR+ AEDLL+F+ +IPAL NS QL++F
Sbjct: 63 AYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEF 122
Query: 125 FKGGIINDSSELIGPAEAHSDSLIDT----FPECSTEGFSSDSDLVSLTVDVD------- 173
F+GG + E+ LI T P S + L L V VD
Sbjct: 123 FRGGEVTRPLEVSRDLHILPPPLIPTPPPDDPRLSQLLPAERRGLEELEVPVDPPPSSPA 182
Query: 174 --------SLAELDDGMASNQNSPIRTFGLNL----SSDSSALGAVASDSEQSKTEEERE 221
+ ++ S P+ L L S + A + +E + E E
Sbjct: 183 QEALDLLFNCESTEEASGSPARGPLTEAELALFDPFSKEEGAAPSPTHVAELATMEVESA 242
Query: 222 SRSLFPGSLKPKLGKRD--------YLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLL 273
P + + D YL +A ELI AL+ E+ Y AA YR GV +L
Sbjct: 243 RLDQEPWEPGGQEEEEDGEGGPTPAYLSQATELITQALRDEKAGAYAAALQGYRDGVHVL 302
Query: 274 LEGVQGESSPTRREAVKRRTAEYLMRAESISSLY 307
L+GV + P R+E VK++ AEYL RAE I L+
Sbjct: 303 LQGVPSDPLPARQEGVKKKAAEYLKRAEEILRLH 336
>gi|46370089 sorting nexin 15 isoform B [Homo sapiens]
Length = 256
Score = 163 bits (412), Expect = 9e-40
Identities = 102/257 (39%), Positives = 144/257 (56%), Gaps = 14/257 (5%)
Query: 5 RERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKEL 64
R+ D R YTV++P+ HP+GYT YKVTA+ +S+++PEDV+E++VWKRYSDF+KLH +L
Sbjct: 3 RQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDVKEVVVWKRYSDFRKLHGDL 62
Query: 65 WQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDF 124
H+NLFR E FP F + VFGRF+ +VIEERR+ AEDLL+F+ +IPAL NS QL++F
Sbjct: 63 AYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEF 122
Query: 125 FKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMAS 184
F+GG E+ P E D I P T L + L EL+ +
Sbjct: 123 FRGG------EVTRPLEVSRDLHILPPPLIPTPPPDDPRLSQLLPAERRGLEELEVPVDP 176
Query: 185 NQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEE--------RESRSLFPGSLKPKLGK 236
+SP + L + S A S + TE E +E L K
Sbjct: 177 PPSSPAQEALDLLFNCESTEEASGSPARGPLTEAELALFDPFSKEGDPLPARQEGVKKKA 236
Query: 237 RDYLEKAGELIKLALKK 253
+YL++A E+++L L +
Sbjct: 237 AEYLKRAEEILRLHLSQ 253
Score = 34.7 bits (78), Expect = 0.49
Identities = 15/30 (50%), Positives = 21/30 (70%)
Query: 278 QGESSPTRREAVKRRTAEYLMRAESISSLY 307
+G+ P R+E VK++ AEYL RAE I L+
Sbjct: 221 EGDPLPARQEGVKKKAAEYLKRAEEILRLH 250
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 isoform
b [Homo sapiens]
Length = 741
Score = 126 bits (317), Expect = 1e-28
Identities = 73/180 (40%), Positives = 100/180 (55%), Gaps = 9/180 (5%)
Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954
L+ E ++ + AE+ +ALD LH GI+ RDL P NILL++ GHI++T F E
Sbjct: 158 LSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEA 217
Query: 955 EDSCDSDAIERM----YCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVEC----HPA 1006
D D A Y APEV T++ DWWS G ++FE+LTG +
Sbjct: 218 IDH-DKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETM 276
Query: 1007 GINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
+ L MP+ +S EA+SL++ L + NP RLGAG+ GVE+IK HPFF +DW L R
Sbjct: 277 ALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYR 336
Score = 47.0 bits (110), Expect = 1e-04
Identities = 38/144 (26%), Positives = 62/144 (43%), Gaps = 18/144 (12%)
Query: 917 LDALHREGIVCRDLNPNNILLNDRG----HIQLTYFSRWSEVEDS---CDSDAIERMYCA 969
+D LH +G+V RDL P+NIL D I++ F ++ + + A
Sbjct: 528 MDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVA 587
Query: 970 PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018
PEV ACD WSLG +L+ +L G T P + +
Sbjct: 588 PEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWD 647
Query: 1019 CVSEEARSLIQQLLQFNPLERLGA 1042
+S+ A+ ++ ++L +P +RL A
Sbjct: 648 SISDAAKDVVSKMLHVDPHQRLTA 671
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 isoform
a [Homo sapiens]
Length = 733
Score = 126 bits (317), Expect = 1e-28
Identities = 73/180 (40%), Positives = 100/180 (55%), Gaps = 9/180 (5%)
Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954
L+ E ++ + AE+ +ALD LH GI+ RDL P NILL++ GHI++T F E
Sbjct: 150 LSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEA 209
Query: 955 EDSCDSDAIERM----YCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVEC----HPA 1006
D D A Y APEV T++ DWWS G ++FE+LTG +
Sbjct: 210 IDH-DKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETM 268
Query: 1007 GINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
+ L MP+ +S EA+SL++ L + NP RLGAG+ GVE+IK HPFF +DW L R
Sbjct: 269 ALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYR 328
Score = 47.0 bits (110), Expect = 1e-04
Identities = 38/144 (26%), Positives = 62/144 (43%), Gaps = 18/144 (12%)
Query: 917 LDALHREGIVCRDLNPNNILLNDRG----HIQLTYFSRWSEVEDS---CDSDAIERMYCA 969
+D LH +G+V RDL P+NIL D I++ F ++ + + A
Sbjct: 520 MDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVA 579
Query: 970 PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018
PEV ACD WSLG +L+ +L G T P + +
Sbjct: 580 PEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWD 639
Query: 1019 CVSEEARSLIQQLLQFNPLERLGA 1042
+S+ A+ ++ ++L +P +RL A
Sbjct: 640 SISDAAKDVVSKMLHVDPHQRLTA 663
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 122 bits (307), Expect = 1e-27
Identities = 76/183 (41%), Positives = 103/183 (56%), Gaps = 15/183 (8%)
Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954
L+ E ++ + AE+ +ALD LH GI+ RDL P NILL++ GHI+LT F E
Sbjct: 159 LSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKE- 217
Query: 955 EDSCDSDAIERMYC------APEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGI 1008
S D + +C APEV T++ DWWS G ++FE+LTG TL
Sbjct: 218 --SIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG-TLPFQGKDRK 274
Query: 1009 NTHTT-----LNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAE 1063
T T L MP+ +S EA+SL++ L + NP RLGAG GVE+IK H FF+ +DW +
Sbjct: 275 ETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNK 334
Query: 1064 LMR 1066
L R
Sbjct: 335 LYR 337
Score = 50.1 bits (118), Expect = 1e-05
Identities = 46/166 (27%), Positives = 71/166 (42%), Gaps = 25/166 (15%)
Query: 917 LDALHREGIVCRDLNPNNILLNDRG------HIQLTYFSRWSEVEDSC-DSDAIERMYCA 969
++ LH +G+V RDL P+NIL D I F++ E+ + + A
Sbjct: 527 VEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVA 586
Query: 970 PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018
PEV ACD WSLG +L+ +LTG T P +
Sbjct: 587 PEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWN 646
Query: 1019 CVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAEL 1064
VS+ A+ L+ ++L +P +RL A + + HP+ V W +L
Sbjct: 647 SVSDTAKDLVSKMLHVDPHQRLTAAL-----VLRHPWI--VHWDQL 685
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform
b [Homo sapiens]
Length = 744
Score = 114 bits (286), Expect = 4e-25
Identities = 67/179 (37%), Positives = 96/179 (53%), Gaps = 7/179 (3%)
Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954
L+ E ++ + AE+ + LD LH GI+ RDL P NILL++ GHI+LT F E
Sbjct: 162 LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEA 221
Query: 955 ---EDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVEC----HPAG 1007
E S Y APEV + + DWWS G ++FE+LTG +
Sbjct: 222 IDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMT 281
Query: 1008 INTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
+ L MP+ +S EA+SL++ L + NP RLG+G G E+IK H F++ +DW +L R
Sbjct: 282 LILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYR 340
Score = 52.0 bits (123), Expect = 3e-06
Identities = 45/162 (27%), Positives = 69/162 (42%), Gaps = 23/162 (14%)
Query: 917 LDALHREGIVCRDLNPNNILLNDRG------HIQLTYFSRWSEVEDSC-DSDAIERMYCA 969
++ LH +G+V RDL P+NIL D I F++ E+ + + A
Sbjct: 532 VEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA 591
Query: 970 PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018
PEV E CD WSLG +L+ +L G T P+ +
Sbjct: 592 PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 651
Query: 1019 CVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVD 1060
VSE A+ L+ ++L +P +RL A + + HP+ T D
Sbjct: 652 TVSETAKDLVSKMLHVDPHQRLTA-----KQVLQHPWVTQKD 688
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform
a [Homo sapiens]
Length = 735
Score = 114 bits (286), Expect = 4e-25
Identities = 67/179 (37%), Positives = 96/179 (53%), Gaps = 7/179 (3%)
Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954
L+ E ++ + AE+ + LD LH GI+ RDL P NILL++ GHI+LT F E
Sbjct: 153 LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEA 212
Query: 955 ---EDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVEC----HPAG 1007
E S Y APEV + + DWWS G ++FE+LTG +
Sbjct: 213 IDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMT 272
Query: 1008 INTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
+ L MP+ +S EA+SL++ L + NP RLG+G G E+IK H F++ +DW +L R
Sbjct: 273 LILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYR 331
Score = 52.0 bits (123), Expect = 3e-06
Identities = 45/162 (27%), Positives = 69/162 (42%), Gaps = 23/162 (14%)
Query: 917 LDALHREGIVCRDLNPNNILLNDRG------HIQLTYFSRWSEVEDSC-DSDAIERMYCA 969
++ LH +G+V RDL P+NIL D I F++ E+ + + A
Sbjct: 523 VEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA 582
Query: 970 PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018
PEV E CD WSLG +L+ +L G T P+ +
Sbjct: 583 PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 642
Query: 1019 CVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVD 1060
VSE A+ L+ ++L +P +RL A + + HP+ T D
Sbjct: 643 TVSETAKDLVSKMLHVDPHQRLTA-----KQVLQHPWVTQKD 679
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 113 bits (282), Expect = 1e-24
Identities = 79/218 (36%), Positives = 119/218 (54%), Gaps = 38/218 (17%)
Query: 867 ETKGESGLVLE----GDKEIHQIFEDLDKKLALASRFYIPEGCIQRWAAEMVVALDALHR 922
+T+G+ L+L+ GD +F L K++ E ++ + AE+ +ALD LH+
Sbjct: 143 QTEGKLYLILDFLRGGD-----VFTRLSKEVLFT------EEDVKFYLAELALALDHLHQ 191
Query: 923 EGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYC------APEVGAIT 976
GIV RDL P NILL++ GHI+LT F E S D + +C APEV
Sbjct: 192 LGIVYRDLKPENILLDEIGHIKLTDFGLSKE---SVDQEKKAYSFCGTVEYMAPEVVNRR 248
Query: 977 EETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLN--------MPECVSEEARSLI 1028
+++ DWWS G ++FE+LTG + G + + T+N MP+ +S EA+SL+
Sbjct: 249 GHSQSADWWSYGVLMFEMLTGTLPFQ----GKDRNETMNMILKAKLGMPQFLSAEAQSLL 304
Query: 1029 QQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
+ L + NP RLG+ GVE+IK H FF +DW +L +
Sbjct: 305 RMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYK 340
Score = 46.6 bits (109), Expect = 1e-04
Identities = 43/162 (26%), Positives = 66/162 (40%), Gaps = 23/162 (14%)
Query: 917 LDALHREGIVCRDLNPNNILLNDRG----HIQLTYFSRWSEVEDSCD---SDAIERMYCA 969
+D LH +G+V RDL P+NIL D I++ F ++ + + A
Sbjct: 531 VDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVA 590
Query: 970 PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018
PEV ACD WSLG + + +L G T P L + +
Sbjct: 591 PEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWD 650
Query: 1019 CVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVD 1060
+S+ A+ L+ +L +P +R A E I H + T D
Sbjct: 651 NISDGAKDLLSHMLHMDPHQRYTA-----EQILKHSWITHRD 687
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 112 bits (281), Expect = 1e-24
Identities = 63/171 (36%), Positives = 97/171 (56%), Gaps = 21/171 (12%)
Query: 909 WAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYC 968
+ AE+ +AL LH++GI+ RDL P NI+LN +GH++LT F E S + +C
Sbjct: 198 YLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKE---SIHDGTVTHTFC 254
Query: 969 ------APEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTT--------L 1014
APE+ + A DWWSLGA+++++LTG G N T L
Sbjct: 255 GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPF----TGENRKKTIDKILKCKL 310
Query: 1015 NMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELM 1065
N+P +++EAR L+++LL+ N RLGAG ++++HPFF ++W EL+
Sbjct: 311 NLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELL 361
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 106 bits (265), Expect = 1e-22
Identities = 58/171 (33%), Positives = 94/171 (54%), Gaps = 21/171 (12%)
Query: 909 WAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYC 968
+ AE+ +AL LH +GI+ RDL P NI+L+ +GHI+LT F E S A+ +C
Sbjct: 174 YLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKE---SIHEGAVTHTFC 230
Query: 969 ------APEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLN------- 1015
APE+ + A DWWSLGA+++++LTG N T++
Sbjct: 231 GTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAE----NRKKTMDKIIRGKL 286
Query: 1016 -MPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELM 1065
+P ++ +AR L+++ L+ NP +R+G G D++ HPFF ++W +L+
Sbjct: 287 ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLL 337
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform
b [Homo sapiens]
Length = 766
Score = 104 bits (260), Expect = 4e-22
Identities = 67/192 (34%), Positives = 100/192 (52%), Gaps = 31/192 (16%)
Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSR---- 950
L R Y E ++ + E+V+AL+ LH+ GI+ RDL N+LL+ GHI LT F
Sbjct: 127 LYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEF 186
Query: 951 WSEVEDSCDSDAIERMYCAPE-VGAITEETEACDWWSLGAVLFELLTG------------ 997
+E ++ S Y APE + + T +A DWWSLG +LFELLTG
Sbjct: 187 LTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNT 246
Query: 998 -----KTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKS 1052
+ +++C P P + A+ L+Q+LL +P +RLGAG G +++++
Sbjct: 247 QAEVSRRILKCSPP---------FPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRN 297
Query: 1053 HPFFTPVDWAEL 1064
HPFF +DW L
Sbjct: 298 HPFFQGLDWVAL 309
Score = 50.1 bits (118), Expect = 1e-05
Identities = 46/156 (29%), Positives = 69/156 (44%), Gaps = 33/156 (21%)
Query: 913 MVVALDALHRE-GIVCRDLNPNNIL-----------LNDRGHIQLTYFSRWSEVEDSCDS 960
+V A+ +H E G+V RDL P NIL + D G +L S ++ C
Sbjct: 507 LVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPC-- 564
Query: 961 DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPEC- 1019
Y APE+ A E+CD WSLG +L+ +L+G+ + +G + C
Sbjct: 565 --FTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQ-GASGQGGQSQAAEIMCK 621
Query: 1020 ---------------VSEEARSLIQQLLQFNPLERL 1040
VSEEA+ L++ LL +P +RL
Sbjct: 622 IREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRL 657
Score = 30.4 bits (67), Expect = 9.3
Identities = 23/75 (30%), Positives = 36/75 (48%), Gaps = 3/75 (4%)
Query: 359 QTFILKGLRKSSEYSRNRKTIIPRCV---PNMVCLHKYIISEESVFLVLQHAEGGKLWSY 415
Q F +K L + E + R+ R PN+V LH+ + +LVL+ GG+L +
Sbjct: 429 QEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEH 488
Query: 416 ISKFLNRSPEESFDI 430
I K + S E+ I
Sbjct: 489 IRKKRHFSESEASQI 503
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform
a [Homo sapiens]
Length = 772
Score = 104 bits (260), Expect = 4e-22
Identities = 67/192 (34%), Positives = 100/192 (52%), Gaps = 31/192 (16%)
Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSR---- 950
L R Y E ++ + E+V+AL+ LH+ GI+ RDL N+LL+ GHI LT F
Sbjct: 127 LYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEF 186
Query: 951 WSEVEDSCDSDAIERMYCAPE-VGAITEETEACDWWSLGAVLFELLTG------------ 997
+E ++ S Y APE + + T +A DWWSLG +LFELLTG
Sbjct: 187 LTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNT 246
Query: 998 -----KTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKS 1052
+ +++C P P + A+ L+Q+LL +P +RLGAG G +++++
Sbjct: 247 QAEVSRRILKCSPP---------FPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRN 297
Query: 1053 HPFFTPVDWAEL 1064
HPFF +DW L
Sbjct: 298 HPFFQGLDWVAL 309
Score = 50.1 bits (118), Expect = 1e-05
Identities = 46/156 (29%), Positives = 69/156 (44%), Gaps = 33/156 (21%)
Query: 913 MVVALDALHRE-GIVCRDLNPNNIL-----------LNDRGHIQLTYFSRWSEVEDSCDS 960
+V A+ +H E G+V RDL P NIL + D G +L S ++ C
Sbjct: 513 LVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPC-- 570
Query: 961 DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPEC- 1019
Y APE+ A E+CD WSLG +L+ +L+G+ + +G + C
Sbjct: 571 --FTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQ-GASGQGGQSQAAEIMCK 627
Query: 1020 ---------------VSEEARSLIQQLLQFNPLERL 1040
VSEEA+ L++ LL +P +RL
Sbjct: 628 IREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRL 663
Score = 30.4 bits (67), Expect = 9.3
Identities = 23/75 (30%), Positives = 36/75 (48%), Gaps = 3/75 (4%)
Query: 359 QTFILKGLRKSSEYSRNRKTIIPRCV---PNMVCLHKYIISEESVFLVLQHAEGGKLWSY 415
Q F +K L + E + R+ R PN+V LH+ + +LVL+ GG+L +
Sbjct: 435 QEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEH 494
Query: 416 ISKFLNRSPEESFDI 430
I K + S E+ I
Sbjct: 495 IRKKRHFSESEASQI 509
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 104 bits (259), Expect = 5e-22
Identities = 85/247 (34%), Positives = 122/247 (49%), Gaps = 41/247 (16%)
Query: 852 DLAKEEPTSLF--QRDSETKGESGLVLEGDKEIHQIFEDLD------------KKLALAS 897
++ K T+ F +RD KG+S V +H F+D + L L S
Sbjct: 106 EMLKRAETACFREERDVLVKGDSRWVTT----LHYAFQDEEYLYLVMDYYAGGDLLTLLS 161
Query: 898 RFY--IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVE 955
RF +P Q + AEMV+A+ +LH+ G V RD+ P+N+LL+ GHI+L F +
Sbjct: 162 RFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLN 221
Query: 956 DSCDSDAIERM----YCAPEVGAITEETEA-----CDWWSLGAVLFELLTGKT------L 1000
+ D+ + Y +PE+ EE + CDWWSLG +ELL G+T L
Sbjct: 222 TNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESL 281
Query: 1001 VECHPAGINTHTTLNMPECVSE---EARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFT 1057
VE + +N L P V + A+ LI+QLL ERLG G G++D ++HPFF
Sbjct: 282 VETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLL-CRQEERLGRG--GLDDFRNHPFFE 338
Query: 1058 PVDWAEL 1064
VDW L
Sbjct: 339 GVDWERL 345
Score = 35.4 bits (80), Expect = 0.29
Identities = 27/107 (25%), Positives = 49/107 (45%), Gaps = 10/107 (9%)
Query: 330 LRSPAEELKAFRVLG--VIDKVLLVMDTRTEQTFILKGLRK--------SSEYSRNRKTI 379
LR ++ + +V+G +V +V T Q F +K L K ++ + R +
Sbjct: 64 LRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVL 123
Query: 380 IPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEE 426
+ + LH EE ++LV+ + GG L + +S+F +R P E
Sbjct: 124 VKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPE 170
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 99.4 bits (246), Expect = 2e-20
Identities = 76/247 (30%), Positives = 123/247 (49%), Gaps = 47/247 (19%)
Query: 852 DLAKEEPTSLFQRDSETKGESGLVLEGDKE----IHQIFEDLDKKLALASRFYI------ 901
++ K T+ F+ + + +++ GD + +H F+D D L L +Y+
Sbjct: 112 EMLKRAETACFREERD------VLVNGDNKWITTLHYAFQD-DNNLYLVMDYYVGGDLLT 164
Query: 902 ---------PEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYF-SRW 951
PE + + AEMV+A+D++H+ V RD+ P+NIL++ GHI+L F S
Sbjct: 165 LLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCL 224
Query: 952 SEVEDSCDSDAI---ERMYCAPEVGAITEETEA-----CDWWSLGAVLFELLTGKT---- 999
+ED ++ Y +PE+ E+ + CDWWSLG ++E+L G+T
Sbjct: 225 KLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYA 284
Query: 1000 --LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHP 1054
LVE + +N P VSE A+ LI++L+ + RLG G+ED K HP
Sbjct: 285 ESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLI-CSREHRLGQN--GIEDFKKHP 341
Query: 1055 FFTPVDW 1061
FF+ +DW
Sbjct: 342 FFSGIDW 348
Score = 33.1 bits (74), Expect = 1.4
Identities = 36/156 (23%), Positives = 65/156 (41%), Gaps = 33/156 (21%)
Query: 281 SSPTRREAVKRRTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAF 340
+SP RRE + EYL + KP V Q +R E+ +
Sbjct: 44 NSPLRRE---KNILEYLE--------WAKPFTSKVKQ------------MRLHREDFEIL 80
Query: 341 RVLG--VIDKVLLVMDTRTEQTFILKGLRK--------SSEYSRNRKTIIPRCVPNMVCL 390
+V+G +V +V ++ F +K L K ++ + R ++ + L
Sbjct: 81 KVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTL 140
Query: 391 HKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEE 426
H + +++LV+ + GG L + +SKF +R PE+
Sbjct: 141 HYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPED 176
>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
sapiens]
Length = 1638
Score = 99.4 bits (246), Expect = 2e-20
Identities = 76/247 (30%), Positives = 123/247 (49%), Gaps = 47/247 (19%)
Query: 852 DLAKEEPTSLFQRDSETKGESGLVLEGDKE----IHQIFEDLDKKLALASRFYI------ 901
++ K T+ F+ + + +++ GD + +H F+D D L L +Y+
Sbjct: 112 EMLKRAETACFREERD------VLVNGDNKWITTLHYAFQD-DNNLYLVMDYYVGGDLLT 164
Query: 902 ---------PEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYF-SRW 951
PE + + AEMV+A+D++H+ V RD+ P+NIL++ GHI+L F S
Sbjct: 165 LLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCL 224
Query: 952 SEVEDSCDSDAI---ERMYCAPEVGAITEETEA-----CDWWSLGAVLFELLTGKT---- 999
+ED ++ Y +PE+ E+ + CDWWSLG ++E+L G+T
Sbjct: 225 KLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYA 284
Query: 1000 --LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHP 1054
LVE + +N P VSE A+ LI++L+ + RLG G+ED K HP
Sbjct: 285 ESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLI-CSREHRLGQN--GIEDFKKHP 341
Query: 1055 FFTPVDW 1061
FF+ +DW
Sbjct: 342 FFSGIDW 348
Score = 33.1 bits (74), Expect = 1.4
Identities = 36/156 (23%), Positives = 65/156 (41%), Gaps = 33/156 (21%)
Query: 281 SSPTRREAVKRRTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAF 340
+SP RRE + EYL + KP V Q +R E+ +
Sbjct: 44 NSPLRRE---KNILEYLE--------WAKPFTSKVKQ------------MRLHREDFEIL 80
Query: 341 RVLG--VIDKVLLVMDTRTEQTFILKGLRK--------SSEYSRNRKTIIPRCVPNMVCL 390
+V+G +V +V ++ F +K L K ++ + R ++ + L
Sbjct: 81 KVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTL 140
Query: 391 HKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEE 426
H + +++LV+ + GG L + +SKF +R PE+
Sbjct: 141 HYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPED 176
>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
sapiens]
Length = 1798
Score = 97.4 bits (241), Expect = 6e-20
Identities = 94/323 (29%), Positives = 140/323 (43%), Gaps = 48/323 (14%)
Query: 785 SSGDMSLLPSSDPKFQGLGV-VESAVTANNTE-ESLFRICSPLSGANEYIASTDTLKTEE 842
SS D P +D +G G + S T + + E++ I + GA + T +
Sbjct: 480 SSCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFA 539
Query: 843 VLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEG----DKEIH-----QIFEDLDKKL 893
+ Q L + + +RD T E+ V+ D + H + E D
Sbjct: 540 MKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCAT 599
Query: 894 ALASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFS---- 949
L + +P ++ + AE V+AL+ LH GIV RDL P+N+L+ GHI+LT F
Sbjct: 600 LLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKI 659
Query: 950 -----RWSEVEDSCDSDAIERM---------YCAPEVGAITEETEACDWWSLGAVLFELL 995
+ E + DA E + Y APEV + DWW++G +L+E L
Sbjct: 660 GLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFL 719
Query: 996 TGKTLVECHPAGINTHTTL------------NMPECVSEEARSLIQQLLQFNPLERLGAG 1043
G C P +T L E + +A+ L +LL NPLERLG G
Sbjct: 720 VG-----CVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTG 774
Query: 1044 VAGVEDIKSHPFFTPVDWAELMR 1066
A ++K HPFFT +DW L+R
Sbjct: 775 SA--YEVKQHPFFTGLDWTGLLR 795
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 96.3 bits (238), Expect = 1e-19
Identities = 59/166 (35%), Positives = 88/166 (53%), Gaps = 11/166 (6%)
Query: 909 WAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE---VEDSCDSDAIER 965
+AA +V+ L LH IV RDL +N+LL+ G +++ F E D +
Sbjct: 762 YAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTP 821
Query: 966 MYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLV------ECHPAGINTHTTLNMPEC 1019
+ APEV T T A DWW LG +++E+L G++ E + +N + P
Sbjct: 822 EFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDE--VRYPRF 879
Query: 1020 VSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELM 1065
+S EA S++++LL+ NP RLGA ED+K HPFF +DW+ LM
Sbjct: 880 LSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALM 925
>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
sapiens]
Length = 1570
Score = 95.9 bits (237), Expect = 2e-19
Identities = 93/328 (28%), Positives = 137/328 (41%), Gaps = 47/328 (14%)
Query: 778 VAAVDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDT 837
V ++ SG S P D +G N +++ I + GA + DT
Sbjct: 338 VVHLEEQDSGG-SNTPEQDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDT 396
Query: 838 LKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVL------EGDKEIHQIFEDL-- 889
+ + Q L + + +RD T E+ V+ E + + + E +
Sbjct: 397 RQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEG 456
Query: 890 -DKKLALASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYF 948
D L + +P + + AE V+AL+ LH GIV RDL P+N+L+ GHI+LT F
Sbjct: 457 GDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDF 516
Query: 949 S---------RWSEVEDSCDSDAIERM---------YCAPEVGAITEETEACDWWSLGAV 990
+ E + DA E + Y APEV + DWW++G +
Sbjct: 517 GLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGII 576
Query: 991 LFELLTGKTLVECHPAGINTHTTL------------NMPECVSEEARSLIQQLLQFNPLE 1038
L+E L G C P +T L E + EA+ LI LLQ NPL
Sbjct: 577 LYEFLVG-----CVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLV 631
Query: 1039 RLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
RLGAG G ++K H FF +DW L+R
Sbjct: 632 RLGAG--GAFEVKQHSFFRDLDWTGLLR 657
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 95.9 bits (237), Expect = 2e-19
Identities = 68/196 (34%), Positives = 96/196 (48%), Gaps = 37/196 (18%)
Query: 901 IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFS---------RW 951
+P + + AE V+AL+ LH GIV RDL P+N+L+ GHI+LT F
Sbjct: 462 LPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMAT 521
Query: 952 SEVEDSCDSDAIERM---------YCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVE 1002
+ E + DA E + Y APEV + DWW++G VL+E L G
Sbjct: 522 NLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVG----- 576
Query: 1003 CHPAGINTHTTL------------NMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDI 1050
C P +T L E + +A+ LI +LL+ +PL+RLG G G ++
Sbjct: 577 CVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTG--GTHEV 634
Query: 1051 KSHPFFTPVDWAELMR 1066
K HPFF +DWA L+R
Sbjct: 635 KQHPFFLALDWAGLLR 650
>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
Length = 639
Score = 95.5 bits (236), Expect = 2e-19
Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 37/251 (14%)
Query: 836 DTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLAL 895
D LK EV F ++ D L + + Q + E+ L L + + + DL L L
Sbjct: 116 DMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME---YYVGGDL---LTL 169
Query: 896 ASRF--YIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE 953
S+F IP + + AE+V+A+D++HR G V RD+ P+NILL+ GHI+L F +
Sbjct: 170 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 229
Query: 954 VE--------------DSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKT 999
+ D + ++ + P G+ E CDWW+LG +E+ G+T
Sbjct: 230 LRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPE---CDWWALGVFAYEMFYGQT 286
Query: 1000 ------LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDI 1050
E + ++ L++P E V EEAR IQ+LL P RLG G AG D
Sbjct: 287 PFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAG--DF 343
Query: 1051 KSHPFFTPVDW 1061
++HPFF +DW
Sbjct: 344 RTHPFFFGLDW 354
Score = 36.6 bits (83), Expect = 0.13
Identities = 32/133 (24%), Positives = 58/133 (43%), Gaps = 10/133 (7%)
Query: 304 SSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLG--VIDKVLLVMDTRTEQTF 361
S+L G P+ + PP L +R ++ + +V+G +V +V +T Q +
Sbjct: 48 SALSGDPRFFSPTTPPAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVY 107
Query: 362 ILKGLRK--------SSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLW 413
+K + K S + R ++ + LH E ++LV+++ GG L
Sbjct: 108 AMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLL 167
Query: 414 SYISKFLNRSPEE 426
+ +SKF R P E
Sbjct: 168 TLLSKFGERIPAE 180
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 95.5 bits (236), Expect = 2e-19
Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 37/251 (14%)
Query: 836 DTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLAL 895
D LK EV F ++ D L + + Q + E+ L L + + + DL L L
Sbjct: 106 DMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME---YYVGGDL---LTL 159
Query: 896 ASRF--YIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE 953
S+F IP + + AE+V+A+D++HR G V RD+ P+NILL+ GHI+L F +
Sbjct: 160 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219
Query: 954 VE--------------DSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKT 999
+ D + ++ + P G+ E CDWW+LG +E+ G+T
Sbjct: 220 LRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPE---CDWWALGVFAYEMFYGQT 276
Query: 1000 ------LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDI 1050
E + ++ L++P E V EEAR IQ+LL P RLG G AG D
Sbjct: 277 PFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAG--DF 333
Query: 1051 KSHPFFTPVDW 1061
++HPFF +DW
Sbjct: 334 RTHPFFFGLDW 344
>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
Length = 624
Score = 95.5 bits (236), Expect = 2e-19
Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 37/251 (14%)
Query: 836 DTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLAL 895
D LK EV F ++ D L + + Q + E+ L L + + + DL L L
Sbjct: 106 DMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME---YYVGGDL---LTL 159
Query: 896 ASRF--YIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE 953
S+F IP + + AE+V+A+D++HR G V RD+ P+NILL+ GHI+L F +
Sbjct: 160 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219
Query: 954 VE--------------DSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKT 999
+ D + ++ + P G+ E CDWW+LG +E+ G+T
Sbjct: 220 LRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPE---CDWWALGVFAYEMFYGQT 276
Query: 1000 ------LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDI 1050
E + ++ L++P E V EEAR IQ+LL P RLG G AG D
Sbjct: 277 PFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAG--DF 333
Query: 1051 KSHPFFTPVDW 1061
++HPFF +DW
Sbjct: 334 RTHPFFFGLDW 344
>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
sapiens]
Length = 629
Score = 95.5 bits (236), Expect = 2e-19
Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 37/251 (14%)
Query: 836 DTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLAL 895
D LK EV F ++ D L + + Q + E+ L L + + + DL L L
Sbjct: 106 DMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME---YYVGGDL---LTL 159
Query: 896 ASRF--YIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE 953
S+F IP + + AE+V+A+D++HR G V RD+ P+NILL+ GHI+L F +
Sbjct: 160 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219
Query: 954 VE--------------DSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKT 999
+ D + ++ + P G+ E CDWW+LG +E+ G+T
Sbjct: 220 LRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPE---CDWWALGVFAYEMFYGQT 276
Query: 1000 ------LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDI 1050
E + ++ L++P E V EEAR IQ+LL P RLG G AG D
Sbjct: 277 PFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAG--DF 333
Query: 1051 KSHPFFTPVDW 1061
++HPFF +DW
Sbjct: 334 RTHPFFFGLDW 344
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 95.5 bits (236), Expect = 2e-19
Identities = 64/189 (33%), Positives = 98/189 (51%), Gaps = 24/189 (12%)
Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954
L+ R E +Q + E+V+AL+ LH+ GI+ RD+ NILL+ GH+ LT F E
Sbjct: 143 LSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEF 202
Query: 955 EDSCDSDAIERM--------YCAPEV--GAITEETEACDWWSLGAVLFELLTGKTLVECH 1004
+D ER Y AP++ G + +A DWWSLG +++ELLTG +
Sbjct: 203 V----ADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTV- 257
Query: 1005 PAGINTHTTLN---------MPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPF 1055
N+ ++ P+ +S A+ LIQ+LL +P +RLG G ++IK H F
Sbjct: 258 DGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLF 317
Query: 1056 FTPVDWAEL 1064
F ++W +L
Sbjct: 318 FQKINWDDL 326
Score = 32.7 bits (73), Expect = 1.9
Identities = 19/71 (26%), Positives = 39/71 (54%), Gaps = 4/71 (5%)
Query: 350 LLVMDTRTEQTFILKGLRKSSEYSRNRKTIIP--RCVPNMVCLHKYIISEESVFLVLQHA 407
L M + T + K K++E++R + ++ R P +V LH +E + L+L +
Sbjct: 77 LYAMKVLKKATIVQKA--KTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYI 134
Query: 408 EGGKLWSYISK 418
GG+L++++S+
Sbjct: 135 NGGELFTHLSQ 145
Score = 32.7 bits (73), Expect = 1.9
Identities = 24/90 (26%), Positives = 44/90 (48%), Gaps = 3/90 (3%)
Query: 356 RTEQTFILKGLRKSSEYSRNRK-TIIPRCV--PNMVCLHKYIISEESVFLVLQHAEGGKL 412
++ Q F +K + K E + ++ T + C PN+V LH+ + FLV++ GG+L
Sbjct: 447 KSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGEL 506
Query: 413 WSYISKFLNRSPEESFDIKEVKKPTLAKVH 442
+ I K + S E+ I ++ +H
Sbjct: 507 FERIKKKKHFSETEASYIMRKLVSAVSHMH 536
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 95.5 bits (236), Expect = 2e-19
Identities = 64/189 (33%), Positives = 98/189 (51%), Gaps = 24/189 (12%)
Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954
L+ R E +Q + E+V+AL+ LH+ GI+ RD+ NILL+ GH+ LT F E
Sbjct: 143 LSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEF 202
Query: 955 EDSCDSDAIERM--------YCAPEV--GAITEETEACDWWSLGAVLFELLTGKTLVECH 1004
+D ER Y AP++ G + +A DWWSLG +++ELLTG +
Sbjct: 203 V----ADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTV- 257
Query: 1005 PAGINTHTTLN---------MPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPF 1055
N+ ++ P+ +S A+ LIQ+LL +P +RLG G ++IK H F
Sbjct: 258 DGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLF 317
Query: 1056 FTPVDWAEL 1064
F ++W +L
Sbjct: 318 FQKINWDDL 326
Score = 58.2 bits (139), Expect = 4e-08
Identities = 45/175 (25%), Positives = 79/175 (45%), Gaps = 28/175 (16%)
Query: 912 EMVVALDALHREGIVCRDLNPNNILLNDRG-HIQLTY----FSRWSEVEDS-CDSDAIER 965
++V A+ +H G+V RDL P N+L D ++++ F+R ++ +
Sbjct: 527 KLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTL 586
Query: 966 MYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-------- 1017
Y APE+ E+CD WSLG +L+ +L+G+ + H + + + +
Sbjct: 587 HYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDF 646
Query: 1018 -------ECVSEEARSLIQQLLQFNPLERL-------GAGVAGVEDIKSHPFFTP 1058
+ VS+EA+ LIQ LL +P +RL + + S+P TP
Sbjct: 647 SFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTP 701
Score = 32.7 bits (73), Expect = 1.9
Identities = 19/71 (26%), Positives = 39/71 (54%), Gaps = 4/71 (5%)
Query: 350 LLVMDTRTEQTFILKGLRKSSEYSRNRKTIIP--RCVPNMVCLHKYIISEESVFLVLQHA 407
L M + T + K K++E++R + ++ R P +V LH +E + L+L +
Sbjct: 77 LYAMKVLKKATIVQKA--KTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYI 134
Query: 408 EGGKLWSYISK 418
GG+L++++S+
Sbjct: 135 NGGELFTHLSQ 145
Score = 32.7 bits (73), Expect = 1.9
Identities = 24/90 (26%), Positives = 44/90 (48%), Gaps = 3/90 (3%)
Query: 356 RTEQTFILKGLRKSSEYSRNRK-TIIPRCV--PNMVCLHKYIISEESVFLVLQHAEGGKL 412
++ Q F +K + K E + ++ T + C PN+V LH+ + FLV++ GG+L
Sbjct: 447 KSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGEL 506
Query: 413 WSYISKFLNRSPEESFDIKEVKKPTLAKVH 442
+ I K + S E+ I ++ +H
Sbjct: 507 FERIKKKKHFSETEASYIMRKLVSAVSHMH 536
Score = 32.3 bits (72), Expect = 2.4
Identities = 25/71 (35%), Positives = 34/71 (47%), Gaps = 4/71 (5%)
Query: 421 NRSPEESFDIKEVKKPTLAKVHLQQPTSS---PQDSSSFESRGSDGGSMLKALPLKSSLT 477
N+ E F ++ V K LAK + TS+ + SSS S S S K P K +L
Sbjct: 723 NKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTK-TLQ 781
Query: 478 PSSQDDSNQED 488
PS+ DSN +
Sbjct: 782 PSNPADSNNPE 792
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 95.5 bits (236), Expect = 2e-19
Identities = 63/183 (34%), Positives = 99/183 (54%), Gaps = 19/183 (10%)
Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954
L S + +PE + + AE+V+ALDA+H G++ RD+ P+N+LL+ GH++L F ++
Sbjct: 180 LMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKM 239
Query: 955 EDS----CDSDAIERMYCAPEV----GAITEETEACDWWSLGAVLFELLTGKT------L 1000
+++ CD+ Y +PEV G CDWWS+G L+E+L G T L
Sbjct: 240 DETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSL 299
Query: 1001 VECHPAGINTHTTLNMPEC--VSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTP 1058
V + ++ +L PE +S+ A++LI L + RLG GVE+I+ HPFF
Sbjct: 300 VGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREV-RLGRN--GVEEIRQHPFFKN 356
Query: 1059 VDW 1061
W
Sbjct: 357 DQW 359
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 95.1 bits (235), Expect = 3e-19
Identities = 77/249 (30%), Positives = 121/249 (48%), Gaps = 29/249 (11%)
Query: 836 DTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLAL 895
+ LK E F ++ D L + + + E+ L L D + + DL L L
Sbjct: 111 EMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMD---YYVGGDL---LTL 164
Query: 896 ASRFY--IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE 953
S+F +PE + + EMV+A+D++H+ V RD+ P+N+LL+ GHI+L F +
Sbjct: 165 LSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLK 224
Query: 954 VEDSCDSDAIERM----YCAPEVGAITEE-----TEACDWWSLGAVLFELLTGKT----- 999
+ D + + Y +PE+ E+ CDWWSLG ++E+L G+T
Sbjct: 225 MNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAE 284
Query: 1000 -LVECHPAGINTHTTLNMPE---CVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPF 1055
LVE + +N P VSEEA+ LIQ+L+ + RLG G+ED K H F
Sbjct: 285 SLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLI-CSRERRLGQN--GIEDFKKHAF 341
Query: 1056 FTPVDWAEL 1064
F ++W +
Sbjct: 342 FEGLNWENI 350
Score = 33.9 bits (76), Expect = 0.84
Identities = 24/102 (23%), Positives = 48/102 (47%), Gaps = 10/102 (9%)
Query: 335 EELKAFRVLG--VIDKVLLVMDTRTEQTFILKGLRK--------SSEYSRNRKTIIPRCV 384
E+ + +V+G +V +V TE+ + +K L K ++ + R ++
Sbjct: 74 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 133
Query: 385 PNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEE 426
+ LH E ++LV+ + GG L + +SKF ++ PE+
Sbjct: 134 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPED 175
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,963,780
Number of Sequences: 37866
Number of extensions: 1980107
Number of successful extensions: 7073
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 315
Number of HSP's successfully gapped in prelim test: 370
Number of HSP's that attempted gapping in prelim test: 5409
Number of HSP's gapped (non-prelim): 1329
length of query: 1066
length of database: 18,247,518
effective HSP length: 113
effective length of query: 953
effective length of database: 13,968,660
effective search space: 13312132980
effective search space used: 13312132980
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.