Guide to the Human Genome
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Search of human proteins with 19923723

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19923723 ribosomal protein S6 kinase, 52kDa, polypeptide 1
isoform a [Homo sapiens]
         (1066 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19923723 ribosomal protein S6 kinase, 52kDa, polypeptide 1 is...  2119   0.0  
gi|209915591 ribosomal protein S6 kinase, 52kDa, polypeptide 1 i...  2087   0.0  
gi|13899309 ribosomal protein S6 kinase-like 1 [Homo sapiens]         209   9e-54
gi|22547191 sorting nexin 15 isoform A [Homo sapiens]                 201   3e-51
gi|46370089 sorting nexin 15 isoform B [Homo sapiens]                 163   9e-40
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   126   1e-28
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   126   1e-28
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho...   122   1e-27
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   114   4e-25
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   114   4e-25
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]   113   1e-24
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho...   112   1e-24
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H...   106   1e-22
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is...   104   4e-22
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso...   104   4e-22
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom...   104   5e-22
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s...    99   2e-20
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s...    99   2e-20
gi|112363080 microtubule associated serine/threonine kinase 2 [H...    97   6e-20
gi|5453974 protein kinase N2 [Homo sapiens]                            96   1e-19
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho...    96   2e-19
gi|150170729 microtubule associated serine/threonine kinase 3 [H...    96   2e-19
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s...    96   2e-19
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s...    96   2e-19
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s...    96   2e-19
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa...    96   2e-19
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b...    96   2e-19
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a...    96   2e-19
gi|41872583 Rho-associated, coiled-coil containing protein kinas...    96   2e-19
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]          95   3e-19

>gi|19923723 ribosomal protein S6 kinase, 52kDa, polypeptide 1 isoform
            a [Homo sapiens]
          Length = 1066

 Score = 2119 bits (5490), Expect = 0.0
 Identities = 1066/1066 (100%), Positives = 1066/1066 (100%)

Query: 1    MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKL 60
            MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKL
Sbjct: 1    MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKL 60

Query: 61   HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ 120
            HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ
Sbjct: 61   HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ 120

Query: 121  LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD 180
            LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD
Sbjct: 121  LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD 180

Query: 181  GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL 240
            GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL
Sbjct: 181  GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL 240

Query: 241  EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA 300
            EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA
Sbjct: 241  EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA 300

Query: 301  ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT 360
            ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT
Sbjct: 301  ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT 360

Query: 361  FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL 420
            FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL
Sbjct: 361  FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL 420

Query: 421  NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS 480
            NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS
Sbjct: 421  NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS 480

Query: 481  QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN 540
            QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN
Sbjct: 481  QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN 540

Query: 541  GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF 600
            GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF
Sbjct: 541  GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF 600

Query: 601  FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI 660
            FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI
Sbjct: 601  FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI 660

Query: 661  SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI 720
            SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI
Sbjct: 661  SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI 720

Query: 721  IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA 780
            IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA
Sbjct: 721  IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA 780

Query: 781  VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT 840
            VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT
Sbjct: 781  VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT 840

Query: 841  EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY 900
            EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY
Sbjct: 841  EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY 900

Query: 901  IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS 960
            IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS
Sbjct: 901  IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS 960

Query: 961  DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV 1020
            DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV
Sbjct: 961  DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV 1020

Query: 1021 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
            SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR
Sbjct: 1021 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066


>gi|209915591 ribosomal protein S6 kinase, 52kDa, polypeptide 1
            isoform b [Homo sapiens]
          Length = 1054

 Score = 2087 bits (5407), Expect = 0.0
 Identities = 1054/1066 (98%), Positives = 1054/1066 (98%), Gaps = 12/1066 (1%)

Query: 1    MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKL 60
            MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTAR            IIVWKRYSDFKKL
Sbjct: 1    MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTAR------------IIVWKRYSDFKKL 48

Query: 61   HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ 120
            HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ
Sbjct: 49   HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ 108

Query: 121  LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD 180
            LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD
Sbjct: 109  LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD 168

Query: 181  GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL 240
            GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL
Sbjct: 169  GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL 228

Query: 241  EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA 300
            EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA
Sbjct: 229  EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA 288

Query: 301  ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT 360
            ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT
Sbjct: 289  ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT 348

Query: 361  FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL 420
            FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL
Sbjct: 349  FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL 408

Query: 421  NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS 480
            NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS
Sbjct: 409  NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS 468

Query: 481  QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN 540
            QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN
Sbjct: 469  QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN 528

Query: 541  GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF 600
            GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF
Sbjct: 529  GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF 588

Query: 601  FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI 660
            FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI
Sbjct: 589  FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI 648

Query: 661  SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI 720
            SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI
Sbjct: 649  SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI 708

Query: 721  IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA 780
            IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA
Sbjct: 709  IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA 768

Query: 781  VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT 840
            VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT
Sbjct: 769  VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT 828

Query: 841  EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY 900
            EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY
Sbjct: 829  EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY 888

Query: 901  IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS 960
            IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS
Sbjct: 889  IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS 948

Query: 961  DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV 1020
            DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV
Sbjct: 949  DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV 1008

Query: 1021 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
            SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR
Sbjct: 1009 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1054


>gi|13899309 ribosomal protein S6 kinase-like 1 [Homo sapiens]
          Length = 541

 Score =  209 bits (533), Expect = 9e-54
 Identities = 91/165 (55%), Positives = 125/165 (75%)

Query: 901  IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS 960
            + E  +++WAAEM+VAL+ALH +G++CRDL+P N+LL+  GHI+LTYF +WSEVE  C  
Sbjct: 353  VREEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLLDQAGHIRLTYFGQWSEVEPQCCG 412

Query: 961  DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV 1020
            +A++ +Y APEVG I+E TEACDWWS G++L+ELLTG  L + HP+GI  HT L +PE +
Sbjct: 413  EAVDNLYSAPEVGGISELTEACDWWSFGSLLYELLTGMALSQSHPSGIQAHTQLQLPEWL 472

Query: 1021 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELM 1065
            S  A SL+ +LLQF P  RLG G  GV  +KSHPFF+ + W++L+
Sbjct: 473  SRPAASLLTELLQFEPTRRLGMGEGGVSKLKSHPFFSTIQWSKLV 517



 Score =  121 bits (303), Expect = 4e-27
 Identities = 73/185 (39%), Positives = 102/185 (55%), Gaps = 28/185 (15%)

Query: 232 PKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKR 291
           P + KRDYL  A   I+LAL+++  +DYEAA + Y+ GVD+LL G+  + +  RREAVK 
Sbjct: 42  PDMTKRDYLVDAATQIRLALERDVSEDYEAAFNHYQNGVDVLLRGIHVDPNKERREAVKL 101

Query: 292 RTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLL 351
           +  +YL RAE I + +                 RPL +  SP+              V L
Sbjct: 102 KITKYLRRAEEIFNCH---------------LQRPLSSGASPS-------------AVQL 133

Query: 352 VMDTRTEQTFILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGK 411
           V D  T  TF++K L +    SR R TIIP  VP M  L +Y +SE+S+FL L+H +GG 
Sbjct: 134 VQDPATGGTFVVKSLPRCHMVSRERLTIIPHGVPYMTKLLRYFVSEDSIFLHLEHVQGGT 193

Query: 412 LWSYI 416
           LWS++
Sbjct: 194 LWSHL 198


>gi|22547191 sorting nexin 15 isoform A [Homo sapiens]
          Length = 342

 Score =  201 bits (511), Expect = 3e-51
 Identities = 129/334 (38%), Positives = 178/334 (53%), Gaps = 31/334 (9%)

Query: 5   RERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKEL 64
           R+   D  R YTV++P+ HP+GYT YKVTA+ +S+++PEDV+E++VWKRYSDF+KLH +L
Sbjct: 3   RQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDVKEVVVWKRYSDFRKLHGDL 62

Query: 65  WQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDF 124
              H+NLFR  E FP F +  VFGRF+ +VIEERR+ AEDLL+F+ +IPAL NS QL++F
Sbjct: 63  AYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEF 122

Query: 125 FKGGIINDSSELIGPAEAHSDSLIDT----FPECSTEGFSSDSDLVSLTVDVD------- 173
           F+GG +    E+          LI T     P  S    +    L  L V VD       
Sbjct: 123 FRGGEVTRPLEVSRDLHILPPPLIPTPPPDDPRLSQLLPAERRGLEELEVPVDPPPSSPA 182

Query: 174 --------SLAELDDGMASNQNSPIRTFGLNL----SSDSSALGAVASDSEQSKTEEERE 221
                   +    ++   S    P+    L L    S +  A  +    +E +  E E  
Sbjct: 183 QEALDLLFNCESTEEASGSPARGPLTEAELALFDPFSKEEGAAPSPTHVAELATMEVESA 242

Query: 222 SRSLFPGSLKPKLGKRD--------YLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLL 273
                P     +  + D        YL +A ELI  AL+ E+   Y AA   YR GV +L
Sbjct: 243 RLDQEPWEPGGQEEEEDGEGGPTPAYLSQATELITQALRDEKAGAYAAALQGYRDGVHVL 302

Query: 274 LEGVQGESSPTRREAVKRRTAEYLMRAESISSLY 307
           L+GV  +  P R+E VK++ AEYL RAE I  L+
Sbjct: 303 LQGVPSDPLPARQEGVKKKAAEYLKRAEEILRLH 336


>gi|46370089 sorting nexin 15 isoform B [Homo sapiens]
          Length = 256

 Score =  163 bits (412), Expect = 9e-40
 Identities = 102/257 (39%), Positives = 144/257 (56%), Gaps = 14/257 (5%)

Query: 5   RERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKEL 64
           R+   D  R YTV++P+ HP+GYT YKVTA+ +S+++PEDV+E++VWKRYSDF+KLH +L
Sbjct: 3   RQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDVKEVVVWKRYSDFRKLHGDL 62

Query: 65  WQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDF 124
              H+NLFR  E FP F +  VFGRF+ +VIEERR+ AEDLL+F+ +IPAL NS QL++F
Sbjct: 63  AYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEF 122

Query: 125 FKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMAS 184
           F+GG      E+  P E   D  I   P   T           L  +   L EL+  +  
Sbjct: 123 FRGG------EVTRPLEVSRDLHILPPPLIPTPPPDDPRLSQLLPAERRGLEELEVPVDP 176

Query: 185 NQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEE--------RESRSLFPGSLKPKLGK 236
             +SP +     L +  S   A  S +    TE E        +E   L       K   
Sbjct: 177 PPSSPAQEALDLLFNCESTEEASGSPARGPLTEAELALFDPFSKEGDPLPARQEGVKKKA 236

Query: 237 RDYLEKAGELIKLALKK 253
            +YL++A E+++L L +
Sbjct: 237 AEYLKRAEEILRLHLSQ 253



 Score = 34.7 bits (78), Expect = 0.49
 Identities = 15/30 (50%), Positives = 21/30 (70%)

Query: 278 QGESSPTRREAVKRRTAEYLMRAESISSLY 307
           +G+  P R+E VK++ AEYL RAE I  L+
Sbjct: 221 EGDPLPARQEGVKKKAAEYLKRAEEILRLH 250


>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 isoform
            b [Homo sapiens]
          Length = 741

 Score =  126 bits (317), Expect = 1e-28
 Identities = 73/180 (40%), Positives = 100/180 (55%), Gaps = 9/180 (5%)

Query: 895  LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954
            L+      E  ++ + AE+ +ALD LH  GI+ RDL P NILL++ GHI++T F    E 
Sbjct: 158  LSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEA 217

Query: 955  EDSCDSDAIERM----YCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVEC----HPA 1006
             D  D  A        Y APEV      T++ DWWS G ++FE+LTG    +        
Sbjct: 218  IDH-DKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETM 276

Query: 1007 GINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
             +     L MP+ +S EA+SL++ L + NP  RLGAG+ GVE+IK HPFF  +DW  L R
Sbjct: 277  ALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYR 336



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 38/144 (26%), Positives = 62/144 (43%), Gaps = 18/144 (12%)

Query: 917  LDALHREGIVCRDLNPNNILLNDRG----HIQLTYFSRWSEVEDS---CDSDAIERMYCA 969
            +D LH +G+V RDL P+NIL  D       I++  F    ++        +      + A
Sbjct: 528  MDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVA 587

Query: 970  PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018
            PEV        ACD WSLG +L+ +L G T     P          +            +
Sbjct: 588  PEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWD 647

Query: 1019 CVSEEARSLIQQLLQFNPLERLGA 1042
             +S+ A+ ++ ++L  +P +RL A
Sbjct: 648  SISDAAKDVVSKMLHVDPHQRLTA 671


>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 isoform
            a [Homo sapiens]
          Length = 733

 Score =  126 bits (317), Expect = 1e-28
 Identities = 73/180 (40%), Positives = 100/180 (55%), Gaps = 9/180 (5%)

Query: 895  LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954
            L+      E  ++ + AE+ +ALD LH  GI+ RDL P NILL++ GHI++T F    E 
Sbjct: 150  LSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEA 209

Query: 955  EDSCDSDAIERM----YCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVEC----HPA 1006
             D  D  A        Y APEV      T++ DWWS G ++FE+LTG    +        
Sbjct: 210  IDH-DKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETM 268

Query: 1007 GINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
             +     L MP+ +S EA+SL++ L + NP  RLGAG+ GVE+IK HPFF  +DW  L R
Sbjct: 269  ALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYR 328



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 38/144 (26%), Positives = 62/144 (43%), Gaps = 18/144 (12%)

Query: 917  LDALHREGIVCRDLNPNNILLNDRG----HIQLTYFSRWSEVEDS---CDSDAIERMYCA 969
            +D LH +G+V RDL P+NIL  D       I++  F    ++        +      + A
Sbjct: 520  MDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVA 579

Query: 970  PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018
            PEV        ACD WSLG +L+ +L G T     P          +            +
Sbjct: 580  PEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWD 639

Query: 1019 CVSEEARSLIQQLLQFNPLERLGA 1042
             +S+ A+ ++ ++L  +P +RL A
Sbjct: 640  SISDAAKDVVSKMLHVDPHQRLTA 663


>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
            sapiens]
          Length = 740

 Score =  122 bits (307), Expect = 1e-27
 Identities = 76/183 (41%), Positives = 103/183 (56%), Gaps = 15/183 (8%)

Query: 895  LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954
            L+      E  ++ + AE+ +ALD LH  GI+ RDL P NILL++ GHI+LT F    E 
Sbjct: 159  LSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKE- 217

Query: 955  EDSCDSDAIERMYC------APEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGI 1008
              S D +     +C      APEV      T++ DWWS G ++FE+LTG TL        
Sbjct: 218  --SIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG-TLPFQGKDRK 274

Query: 1009 NTHTT-----LNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAE 1063
             T T      L MP+ +S EA+SL++ L + NP  RLGAG  GVE+IK H FF+ +DW +
Sbjct: 275  ETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNK 334

Query: 1064 LMR 1066
            L R
Sbjct: 335  LYR 337



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 46/166 (27%), Positives = 71/166 (42%), Gaps = 25/166 (15%)

Query: 917  LDALHREGIVCRDLNPNNILLNDRG------HIQLTYFSRWSEVEDSC-DSDAIERMYCA 969
            ++ LH +G+V RDL P+NIL  D         I    F++    E+    +      + A
Sbjct: 527  VEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVA 586

Query: 970  PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018
            PEV        ACD WSLG +L+ +LTG T     P          +             
Sbjct: 587  PEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWN 646

Query: 1019 CVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAEL 1064
             VS+ A+ L+ ++L  +P +RL A +     +  HP+   V W +L
Sbjct: 647  SVSDTAKDLVSKMLHVDPHQRLTAAL-----VLRHPWI--VHWDQL 685


>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform
            b [Homo sapiens]
          Length = 744

 Score =  114 bits (286), Expect = 4e-25
 Identities = 67/179 (37%), Positives = 96/179 (53%), Gaps = 7/179 (3%)

Query: 895  LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954
            L+      E  ++ + AE+ + LD LH  GI+ RDL P NILL++ GHI+LT F    E 
Sbjct: 162  LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEA 221

Query: 955  ---EDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVEC----HPAG 1007
               E    S      Y APEV      + + DWWS G ++FE+LTG    +         
Sbjct: 222  IDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMT 281

Query: 1008 INTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
            +     L MP+ +S EA+SL++ L + NP  RLG+G  G E+IK H F++ +DW +L R
Sbjct: 282  LILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYR 340



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 45/162 (27%), Positives = 69/162 (42%), Gaps = 23/162 (14%)

Query: 917  LDALHREGIVCRDLNPNNILLNDRG------HIQLTYFSRWSEVEDSC-DSDAIERMYCA 969
            ++ LH +G+V RDL P+NIL  D         I    F++    E+    +      + A
Sbjct: 532  VEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA 591

Query: 970  PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018
            PEV       E CD WSLG +L+ +L G T     P+         +             
Sbjct: 592  PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 651

Query: 1019 CVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVD 1060
             VSE A+ L+ ++L  +P +RL A     + +  HP+ T  D
Sbjct: 652  TVSETAKDLVSKMLHVDPHQRLTA-----KQVLQHPWVTQKD 688


>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform
            a [Homo sapiens]
          Length = 735

 Score =  114 bits (286), Expect = 4e-25
 Identities = 67/179 (37%), Positives = 96/179 (53%), Gaps = 7/179 (3%)

Query: 895  LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954
            L+      E  ++ + AE+ + LD LH  GI+ RDL P NILL++ GHI+LT F    E 
Sbjct: 153  LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEA 212

Query: 955  ---EDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVEC----HPAG 1007
               E    S      Y APEV      + + DWWS G ++FE+LTG    +         
Sbjct: 213  IDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMT 272

Query: 1008 INTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
            +     L MP+ +S EA+SL++ L + NP  RLG+G  G E+IK H F++ +DW +L R
Sbjct: 273  LILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYR 331



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 45/162 (27%), Positives = 69/162 (42%), Gaps = 23/162 (14%)

Query: 917  LDALHREGIVCRDLNPNNILLNDRG------HIQLTYFSRWSEVEDSC-DSDAIERMYCA 969
            ++ LH +G+V RDL P+NIL  D         I    F++    E+    +      + A
Sbjct: 523  VEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA 582

Query: 970  PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018
            PEV       E CD WSLG +L+ +L G T     P+         +             
Sbjct: 583  PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 642

Query: 1019 CVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVD 1060
             VSE A+ L+ ++L  +P +RL A     + +  HP+ T  D
Sbjct: 643  TVSETAKDLVSKMLHVDPHQRLTA-----KQVLQHPWVTQKD 679


>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
          Length = 745

 Score =  113 bits (282), Expect = 1e-24
 Identities = 79/218 (36%), Positives = 119/218 (54%), Gaps = 38/218 (17%)

Query: 867  ETKGESGLVLE----GDKEIHQIFEDLDKKLALASRFYIPEGCIQRWAAEMVVALDALHR 922
            +T+G+  L+L+    GD     +F  L K++         E  ++ + AE+ +ALD LH+
Sbjct: 143  QTEGKLYLILDFLRGGD-----VFTRLSKEVLFT------EEDVKFYLAELALALDHLHQ 191

Query: 923  EGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYC------APEVGAIT 976
             GIV RDL P NILL++ GHI+LT F    E   S D +     +C      APEV    
Sbjct: 192  LGIVYRDLKPENILLDEIGHIKLTDFGLSKE---SVDQEKKAYSFCGTVEYMAPEVVNRR 248

Query: 977  EETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLN--------MPECVSEEARSLI 1028
              +++ DWWS G ++FE+LTG    +    G + + T+N        MP+ +S EA+SL+
Sbjct: 249  GHSQSADWWSYGVLMFEMLTGTLPFQ----GKDRNETMNMILKAKLGMPQFLSAEAQSLL 304

Query: 1029 QQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
            + L + NP  RLG+   GVE+IK H FF  +DW +L +
Sbjct: 305  RMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYK 340



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 43/162 (26%), Positives = 66/162 (40%), Gaps = 23/162 (14%)

Query: 917  LDALHREGIVCRDLNPNNILLNDRG----HIQLTYFSRWSEVEDSCD---SDAIERMYCA 969
            +D LH +G+V RDL P+NIL  D       I++  F    ++        +      + A
Sbjct: 531  VDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVA 590

Query: 970  PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018
            PEV        ACD WSLG + + +L G T     P        L +            +
Sbjct: 591  PEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWD 650

Query: 1019 CVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVD 1060
             +S+ A+ L+  +L  +P +R  A     E I  H + T  D
Sbjct: 651  NISDGAKDLLSHMLHMDPHQRYTA-----EQILKHSWITHRD 687


>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
            sapiens]
          Length = 525

 Score =  112 bits (281), Expect = 1e-24
 Identities = 63/171 (36%), Positives = 97/171 (56%), Gaps = 21/171 (12%)

Query: 909  WAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYC 968
            + AE+ +AL  LH++GI+ RDL P NI+LN +GH++LT F    E   S     +   +C
Sbjct: 198  YLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKE---SIHDGTVTHTFC 254

Query: 969  ------APEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTT--------L 1014
                  APE+   +    A DWWSLGA+++++LTG         G N   T        L
Sbjct: 255  GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPF----TGENRKKTIDKILKCKL 310

Query: 1015 NMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELM 1065
            N+P  +++EAR L+++LL+ N   RLGAG     ++++HPFF  ++W EL+
Sbjct: 311  NLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELL 361


>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
            sapiens]
          Length = 482

 Score =  106 bits (265), Expect = 1e-22
 Identities = 58/171 (33%), Positives = 94/171 (54%), Gaps = 21/171 (12%)

Query: 909  WAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYC 968
            + AE+ +AL  LH +GI+ RDL P NI+L+ +GHI+LT F    E   S    A+   +C
Sbjct: 174  YLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKE---SIHEGAVTHTFC 230

Query: 969  ------APEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLN------- 1015
                  APE+   +    A DWWSLGA+++++LTG           N   T++       
Sbjct: 231  GTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAE----NRKKTMDKIIRGKL 286

Query: 1016 -MPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELM 1065
             +P  ++ +AR L+++ L+ NP +R+G G     D++ HPFF  ++W +L+
Sbjct: 287  ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLL 337


>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform
            b [Homo sapiens]
          Length = 766

 Score =  104 bits (260), Expect = 4e-22
 Identities = 67/192 (34%), Positives = 100/192 (52%), Gaps = 31/192 (16%)

Query: 895  LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSR---- 950
            L  R Y  E  ++ +  E+V+AL+ LH+ GI+ RDL   N+LL+  GHI LT F      
Sbjct: 127  LYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEF 186

Query: 951  WSEVEDSCDSDAIERMYCAPE-VGAITEETEACDWWSLGAVLFELLTG------------ 997
             +E ++   S      Y APE + + T   +A DWWSLG +LFELLTG            
Sbjct: 187  LTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNT 246

Query: 998  -----KTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKS 1052
                 + +++C P           P  +   A+ L+Q+LL  +P +RLGAG  G +++++
Sbjct: 247  QAEVSRRILKCSPP---------FPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRN 297

Query: 1053 HPFFTPVDWAEL 1064
            HPFF  +DW  L
Sbjct: 298  HPFFQGLDWVAL 309



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 46/156 (29%), Positives = 69/156 (44%), Gaps = 33/156 (21%)

Query: 913  MVVALDALHRE-GIVCRDLNPNNIL-----------LNDRGHIQLTYFSRWSEVEDSCDS 960
            +V A+  +H E G+V RDL P NIL           + D G  +L   S    ++  C  
Sbjct: 507  LVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPC-- 564

Query: 961  DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPEC- 1019
                  Y APE+ A     E+CD WSLG +L+ +L+G+   +   +G    +      C 
Sbjct: 565  --FTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQ-GASGQGGQSQAAEIMCK 621

Query: 1020 ---------------VSEEARSLIQQLLQFNPLERL 1040
                           VSEEA+ L++ LL  +P +RL
Sbjct: 622  IREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRL 657



 Score = 30.4 bits (67), Expect = 9.3
 Identities = 23/75 (30%), Positives = 36/75 (48%), Gaps = 3/75 (4%)

Query: 359 QTFILKGLRKSSEYSRNRKTIIPRCV---PNMVCLHKYIISEESVFLVLQHAEGGKLWSY 415
           Q F +K L +  E +  R+    R     PN+V LH+    +   +LVL+   GG+L  +
Sbjct: 429 QEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEH 488

Query: 416 ISKFLNRSPEESFDI 430
           I K  + S  E+  I
Sbjct: 489 IRKKRHFSESEASQI 503


>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform
            a [Homo sapiens]
          Length = 772

 Score =  104 bits (260), Expect = 4e-22
 Identities = 67/192 (34%), Positives = 100/192 (52%), Gaps = 31/192 (16%)

Query: 895  LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSR---- 950
            L  R Y  E  ++ +  E+V+AL+ LH+ GI+ RDL   N+LL+  GHI LT F      
Sbjct: 127  LYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEF 186

Query: 951  WSEVEDSCDSDAIERMYCAPE-VGAITEETEACDWWSLGAVLFELLTG------------ 997
             +E ++   S      Y APE + + T   +A DWWSLG +LFELLTG            
Sbjct: 187  LTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNT 246

Query: 998  -----KTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKS 1052
                 + +++C P           P  +   A+ L+Q+LL  +P +RLGAG  G +++++
Sbjct: 247  QAEVSRRILKCSPP---------FPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRN 297

Query: 1053 HPFFTPVDWAEL 1064
            HPFF  +DW  L
Sbjct: 298  HPFFQGLDWVAL 309



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 46/156 (29%), Positives = 69/156 (44%), Gaps = 33/156 (21%)

Query: 913  MVVALDALHRE-GIVCRDLNPNNIL-----------LNDRGHIQLTYFSRWSEVEDSCDS 960
            +V A+  +H E G+V RDL P NIL           + D G  +L   S    ++  C  
Sbjct: 513  LVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPC-- 570

Query: 961  DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPEC- 1019
                  Y APE+ A     E+CD WSLG +L+ +L+G+   +   +G    +      C 
Sbjct: 571  --FTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQ-GASGQGGQSQAAEIMCK 627

Query: 1020 ---------------VSEEARSLIQQLLQFNPLERL 1040
                           VSEEA+ L++ LL  +P +RL
Sbjct: 628  IREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRL 663



 Score = 30.4 bits (67), Expect = 9.3
 Identities = 23/75 (30%), Positives = 36/75 (48%), Gaps = 3/75 (4%)

Query: 359 QTFILKGLRKSSEYSRNRKTIIPRCV---PNMVCLHKYIISEESVFLVLQHAEGGKLWSY 415
           Q F +K L +  E +  R+    R     PN+V LH+    +   +LVL+   GG+L  +
Sbjct: 435 QEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEH 494

Query: 416 ISKFLNRSPEESFDI 430
           I K  + S  E+  I
Sbjct: 495 IRKKRHFSESEASQI 509


>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
            sapiens]
          Length = 1551

 Score =  104 bits (259), Expect = 5e-22
 Identities = 85/247 (34%), Positives = 122/247 (49%), Gaps = 41/247 (16%)

Query: 852  DLAKEEPTSLF--QRDSETKGESGLVLEGDKEIHQIFEDLD------------KKLALAS 897
            ++ K   T+ F  +RD   KG+S  V      +H  F+D +              L L S
Sbjct: 106  EMLKRAETACFREERDVLVKGDSRWVTT----LHYAFQDEEYLYLVMDYYAGGDLLTLLS 161

Query: 898  RFY--IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVE 955
            RF   +P    Q + AEMV+A+ +LH+ G V RD+ P+N+LL+  GHI+L  F     + 
Sbjct: 162  RFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLN 221

Query: 956  DSCDSDAIERM----YCAPEVGAITEETEA-----CDWWSLGAVLFELLTGKT------L 1000
             +   D+   +    Y +PE+    EE +      CDWWSLG   +ELL G+T      L
Sbjct: 222  TNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESL 281

Query: 1001 VECHPAGINTHTTLNMPECVSE---EARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFT 1057
            VE +   +N    L  P  V +    A+ LI+QLL     ERLG G  G++D ++HPFF 
Sbjct: 282  VETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLL-CRQEERLGRG--GLDDFRNHPFFE 338

Query: 1058 PVDWAEL 1064
             VDW  L
Sbjct: 339  GVDWERL 345



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 27/107 (25%), Positives = 49/107 (45%), Gaps = 10/107 (9%)

Query: 330 LRSPAEELKAFRVLG--VIDKVLLVMDTRTEQTFILKGLRK--------SSEYSRNRKTI 379
           LR   ++ +  +V+G     +V +V    T Q F +K L K        ++ +   R  +
Sbjct: 64  LRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVL 123

Query: 380 IPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEE 426
           +      +  LH     EE ++LV+ +  GG L + +S+F +R P E
Sbjct: 124 VKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPE 170


>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
            sapiens]
          Length = 1719

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 76/247 (30%), Positives = 123/247 (49%), Gaps = 47/247 (19%)

Query: 852  DLAKEEPTSLFQRDSETKGESGLVLEGDKE----IHQIFEDLDKKLALASRFYI------ 901
            ++ K   T+ F+ + +      +++ GD +    +H  F+D D  L L   +Y+      
Sbjct: 112  EMLKRAETACFREERD------VLVNGDNKWITTLHYAFQD-DNNLYLVMDYYVGGDLLT 164

Query: 902  ---------PEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYF-SRW 951
                     PE   + + AEMV+A+D++H+   V RD+ P+NIL++  GHI+L  F S  
Sbjct: 165  LLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCL 224

Query: 952  SEVEDSCDSDAI---ERMYCAPEVGAITEETEA-----CDWWSLGAVLFELLTGKT---- 999
              +ED     ++      Y +PE+    E+ +      CDWWSLG  ++E+L G+T    
Sbjct: 225  KLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYA 284

Query: 1000 --LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHP 1054
              LVE +   +N       P     VSE A+ LI++L+  +   RLG    G+ED K HP
Sbjct: 285  ESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLI-CSREHRLGQN--GIEDFKKHP 341

Query: 1055 FFTPVDW 1061
            FF+ +DW
Sbjct: 342  FFSGIDW 348



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 36/156 (23%), Positives = 65/156 (41%), Gaps = 33/156 (21%)

Query: 281 SSPTRREAVKRRTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAF 340
           +SP RRE   +   EYL         + KP    V Q            +R   E+ +  
Sbjct: 44  NSPLRRE---KNILEYLE--------WAKPFTSKVKQ------------MRLHREDFEIL 80

Query: 341 RVLG--VIDKVLLVMDTRTEQTFILKGLRK--------SSEYSRNRKTIIPRCVPNMVCL 390
           +V+G     +V +V     ++ F +K L K        ++ +   R  ++      +  L
Sbjct: 81  KVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTL 140

Query: 391 HKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEE 426
           H     + +++LV+ +  GG L + +SKF +R PE+
Sbjct: 141 HYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPED 176


>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
            sapiens]
          Length = 1638

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 76/247 (30%), Positives = 123/247 (49%), Gaps = 47/247 (19%)

Query: 852  DLAKEEPTSLFQRDSETKGESGLVLEGDKE----IHQIFEDLDKKLALASRFYI------ 901
            ++ K   T+ F+ + +      +++ GD +    +H  F+D D  L L   +Y+      
Sbjct: 112  EMLKRAETACFREERD------VLVNGDNKWITTLHYAFQD-DNNLYLVMDYYVGGDLLT 164

Query: 902  ---------PEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYF-SRW 951
                     PE   + + AEMV+A+D++H+   V RD+ P+NIL++  GHI+L  F S  
Sbjct: 165  LLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCL 224

Query: 952  SEVEDSCDSDAI---ERMYCAPEVGAITEETEA-----CDWWSLGAVLFELLTGKT---- 999
              +ED     ++      Y +PE+    E+ +      CDWWSLG  ++E+L G+T    
Sbjct: 225  KLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYA 284

Query: 1000 --LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHP 1054
              LVE +   +N       P     VSE A+ LI++L+  +   RLG    G+ED K HP
Sbjct: 285  ESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLI-CSREHRLGQN--GIEDFKKHP 341

Query: 1055 FFTPVDW 1061
            FF+ +DW
Sbjct: 342  FFSGIDW 348



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 36/156 (23%), Positives = 65/156 (41%), Gaps = 33/156 (21%)

Query: 281 SSPTRREAVKRRTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAF 340
           +SP RRE   +   EYL         + KP    V Q            +R   E+ +  
Sbjct: 44  NSPLRRE---KNILEYLE--------WAKPFTSKVKQ------------MRLHREDFEIL 80

Query: 341 RVLG--VIDKVLLVMDTRTEQTFILKGLRK--------SSEYSRNRKTIIPRCVPNMVCL 390
           +V+G     +V +V     ++ F +K L K        ++ +   R  ++      +  L
Sbjct: 81  KVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTL 140

Query: 391 HKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEE 426
           H     + +++LV+ +  GG L + +SKF +R PE+
Sbjct: 141 HYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPED 176


>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
            sapiens]
          Length = 1798

 Score = 97.4 bits (241), Expect = 6e-20
 Identities = 94/323 (29%), Positives = 140/323 (43%), Gaps = 48/323 (14%)

Query: 785  SSGDMSLLPSSDPKFQGLGV-VESAVTANNTE-ESLFRICSPLSGANEYIASTDTLKTEE 842
            SS D    P +D   +G G  + S  T +  + E++  I +   GA   +    T +   
Sbjct: 480  SSCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFA 539

Query: 843  VLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEG----DKEIH-----QIFEDLDKKL 893
            +     Q   L  +   +  +RD  T  E+  V+      D + H     +  E  D   
Sbjct: 540  MKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCAT 599

Query: 894  ALASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFS---- 949
             L +   +P   ++ + AE V+AL+ LH  GIV RDL P+N+L+   GHI+LT F     
Sbjct: 600  LLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKI 659

Query: 950  -----RWSEVEDSCDSDAIERM---------YCAPEVGAITEETEACDWWSLGAVLFELL 995
                   +  E   + DA E +         Y APEV       +  DWW++G +L+E L
Sbjct: 660  GLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFL 719

Query: 996  TGKTLVECHPAGINTHTTL------------NMPECVSEEARSLIQQLLQFNPLERLGAG 1043
             G     C P   +T   L               E +  +A+ L  +LL  NPLERLG G
Sbjct: 720  VG-----CVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTG 774

Query: 1044 VAGVEDIKSHPFFTPVDWAELMR 1066
             A   ++K HPFFT +DW  L+R
Sbjct: 775  SA--YEVKQHPFFTGLDWTGLLR 795


>gi|5453974 protein kinase N2 [Homo sapiens]
          Length = 984

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 59/166 (35%), Positives = 88/166 (53%), Gaps = 11/166 (6%)

Query: 909  WAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE---VEDSCDSDAIER 965
            +AA +V+ L  LH   IV RDL  +N+LL+  G +++  F    E     D   +     
Sbjct: 762  YAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTP 821

Query: 966  MYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLV------ECHPAGINTHTTLNMPEC 1019
             + APEV   T  T A DWW LG +++E+L G++        E   + +N    +  P  
Sbjct: 822  EFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDE--VRYPRF 879

Query: 1020 VSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELM 1065
            +S EA S++++LL+ NP  RLGA     ED+K HPFF  +DW+ LM
Sbjct: 880  LSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALM 925


>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
            sapiens]
          Length = 1570

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 93/328 (28%), Positives = 137/328 (41%), Gaps = 47/328 (14%)

Query: 778  VAAVDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDT 837
            V  ++   SG  S  P  D   +G           N  +++  I +   GA   +   DT
Sbjct: 338  VVHLEEQDSGG-SNTPEQDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDT 396

Query: 838  LKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVL------EGDKEIHQIFEDL-- 889
             +   +     Q   L  +   +  +RD  T  E+  V+      E  + +  + E +  
Sbjct: 397  RQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEG 456

Query: 890  -DKKLALASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYF 948
             D    L +   +P    + + AE V+AL+ LH  GIV RDL P+N+L+   GHI+LT F
Sbjct: 457  GDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDF 516

Query: 949  S---------RWSEVEDSCDSDAIERM---------YCAPEVGAITEETEACDWWSLGAV 990
                        +  E   + DA E +         Y APEV       +  DWW++G +
Sbjct: 517  GLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGII 576

Query: 991  LFELLTGKTLVECHPAGINTHTTL------------NMPECVSEEARSLIQQLLQFNPLE 1038
            L+E L G     C P   +T   L               E +  EA+ LI  LLQ NPL 
Sbjct: 577  LYEFLVG-----CVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLV 631

Query: 1039 RLGAGVAGVEDIKSHPFFTPVDWAELMR 1066
            RLGAG  G  ++K H FF  +DW  L+R
Sbjct: 632  RLGAG--GAFEVKQHSFFRDLDWTGLLR 657


>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
            sapiens]
          Length = 1309

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 68/196 (34%), Positives = 96/196 (48%), Gaps = 37/196 (18%)

Query: 901  IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFS---------RW 951
            +P    + + AE V+AL+ LH  GIV RDL P+N+L+   GHI+LT F            
Sbjct: 462  LPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMAT 521

Query: 952  SEVEDSCDSDAIERM---------YCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVE 1002
            +  E   + DA E +         Y APEV       +  DWW++G VL+E L G     
Sbjct: 522  NLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVG----- 576

Query: 1003 CHPAGINTHTTL------------NMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDI 1050
            C P   +T   L               E +  +A+ LI +LL+ +PL+RLG G  G  ++
Sbjct: 577  CVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTG--GTHEV 634

Query: 1051 KSHPFFTPVDWAELMR 1066
            K HPFF  +DWA L+R
Sbjct: 635  KQHPFFLALDWAGLLR 650


>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
            sapiens]
          Length = 639

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 37/251 (14%)

Query: 836  DTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLAL 895
            D LK  EV  F ++ D L   +   + Q     + E+ L L  +   + +  DL   L L
Sbjct: 116  DMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME---YYVGGDL---LTL 169

Query: 896  ASRF--YIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE 953
             S+F   IP    + + AE+V+A+D++HR G V RD+ P+NILL+  GHI+L  F    +
Sbjct: 170  LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 229

Query: 954  VE--------------DSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKT 999
            +               D    + ++ +   P  G+   E   CDWW+LG   +E+  G+T
Sbjct: 230  LRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPE---CDWWALGVFAYEMFYGQT 286

Query: 1000 ------LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDI 1050
                    E +   ++    L++P   E V EEAR  IQ+LL   P  RLG G AG  D 
Sbjct: 287  PFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAG--DF 343

Query: 1051 KSHPFFTPVDW 1061
            ++HPFF  +DW
Sbjct: 344  RTHPFFFGLDW 354



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 32/133 (24%), Positives = 58/133 (43%), Gaps = 10/133 (7%)

Query: 304 SSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLG--VIDKVLLVMDTRTEQTF 361
           S+L G P+    + PP       L  +R   ++ +  +V+G     +V +V   +T Q +
Sbjct: 48  SALSGDPRFFSPTTPPAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVY 107

Query: 362 ILKGLRK--------SSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLW 413
            +K + K         S +   R  ++      +  LH     E  ++LV+++  GG L 
Sbjct: 108 AMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLL 167

Query: 414 SYISKFLNRSPEE 426
           + +SKF  R P E
Sbjct: 168 TLLSKFGERIPAE 180


>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
            sapiens]
          Length = 625

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 37/251 (14%)

Query: 836  DTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLAL 895
            D LK  EV  F ++ D L   +   + Q     + E+ L L  +   + +  DL   L L
Sbjct: 106  DMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME---YYVGGDL---LTL 159

Query: 896  ASRF--YIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE 953
             S+F   IP    + + AE+V+A+D++HR G V RD+ P+NILL+  GHI+L  F    +
Sbjct: 160  LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219

Query: 954  VE--------------DSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKT 999
            +               D    + ++ +   P  G+   E   CDWW+LG   +E+  G+T
Sbjct: 220  LRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPE---CDWWALGVFAYEMFYGQT 276

Query: 1000 ------LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDI 1050
                    E +   ++    L++P   E V EEAR  IQ+LL   P  RLG G AG  D 
Sbjct: 277  PFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAG--DF 333

Query: 1051 KSHPFFTPVDW 1061
            ++HPFF  +DW
Sbjct: 334  RTHPFFFGLDW 344


>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
            sapiens]
          Length = 624

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 37/251 (14%)

Query: 836  DTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLAL 895
            D LK  EV  F ++ D L   +   + Q     + E+ L L  +   + +  DL   L L
Sbjct: 106  DMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME---YYVGGDL---LTL 159

Query: 896  ASRF--YIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE 953
             S+F   IP    + + AE+V+A+D++HR G V RD+ P+NILL+  GHI+L  F    +
Sbjct: 160  LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219

Query: 954  VE--------------DSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKT 999
            +               D    + ++ +   P  G+   E   CDWW+LG   +E+  G+T
Sbjct: 220  LRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPE---CDWWALGVFAYEMFYGQT 276

Query: 1000 ------LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDI 1050
                    E +   ++    L++P   E V EEAR  IQ+LL   P  RLG G AG  D 
Sbjct: 277  PFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAG--DF 333

Query: 1051 KSHPFFTPVDW 1061
            ++HPFF  +DW
Sbjct: 334  RTHPFFFGLDW 344


>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
            sapiens]
          Length = 629

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 37/251 (14%)

Query: 836  DTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLAL 895
            D LK  EV  F ++ D L   +   + Q     + E+ L L  +   + +  DL   L L
Sbjct: 106  DMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME---YYVGGDL---LTL 159

Query: 896  ASRF--YIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE 953
             S+F   IP    + + AE+V+A+D++HR G V RD+ P+NILL+  GHI+L  F    +
Sbjct: 160  LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219

Query: 954  VE--------------DSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKT 999
            +               D    + ++ +   P  G+   E   CDWW+LG   +E+  G+T
Sbjct: 220  LRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPE---CDWWALGVFAYEMFYGQT 276

Query: 1000 ------LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDI 1050
                    E +   ++    L++P   E V EEAR  IQ+LL   P  RLG G AG  D 
Sbjct: 277  PFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAG--DF 333

Query: 1051 KSHPFFTPVDW 1061
            ++HPFF  +DW
Sbjct: 334  RTHPFFFGLDW 344


>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
            [Homo sapiens]
          Length = 549

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 64/189 (33%), Positives = 98/189 (51%), Gaps = 24/189 (12%)

Query: 895  LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954
            L+ R    E  +Q +  E+V+AL+ LH+ GI+ RD+   NILL+  GH+ LT F    E 
Sbjct: 143  LSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEF 202

Query: 955  EDSCDSDAIERM--------YCAPEV--GAITEETEACDWWSLGAVLFELLTGKTLVECH 1004
                 +D  ER         Y AP++  G  +   +A DWWSLG +++ELLTG +     
Sbjct: 203  V----ADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTV- 257

Query: 1005 PAGINTHTTLN---------MPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPF 1055
                N+   ++          P+ +S  A+ LIQ+LL  +P +RLG G    ++IK H F
Sbjct: 258  DGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLF 317

Query: 1056 FTPVDWAEL 1064
            F  ++W +L
Sbjct: 318  FQKINWDDL 326



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 19/71 (26%), Positives = 39/71 (54%), Gaps = 4/71 (5%)

Query: 350 LLVMDTRTEQTFILKGLRKSSEYSRNRKTIIP--RCVPNMVCLHKYIISEESVFLVLQHA 407
           L  M    + T + K   K++E++R  + ++   R  P +V LH    +E  + L+L + 
Sbjct: 77  LYAMKVLKKATIVQKA--KTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYI 134

Query: 408 EGGKLWSYISK 418
            GG+L++++S+
Sbjct: 135 NGGELFTHLSQ 145



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 24/90 (26%), Positives = 44/90 (48%), Gaps = 3/90 (3%)

Query: 356 RTEQTFILKGLRKSSEYSRNRK-TIIPRCV--PNMVCLHKYIISEESVFLVLQHAEGGKL 412
           ++ Q F +K + K  E +  ++ T +  C   PN+V LH+    +   FLV++   GG+L
Sbjct: 447 KSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGEL 506

Query: 413 WSYISKFLNRSPEESFDIKEVKKPTLAKVH 442
           +  I K  + S  E+  I       ++ +H
Sbjct: 507 FERIKKKKHFSETEASYIMRKLVSAVSHMH 536


>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
            [Homo sapiens]
          Length = 802

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 64/189 (33%), Positives = 98/189 (51%), Gaps = 24/189 (12%)

Query: 895  LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954
            L+ R    E  +Q +  E+V+AL+ LH+ GI+ RD+   NILL+  GH+ LT F    E 
Sbjct: 143  LSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEF 202

Query: 955  EDSCDSDAIERM--------YCAPEV--GAITEETEACDWWSLGAVLFELLTGKTLVECH 1004
                 +D  ER         Y AP++  G  +   +A DWWSLG +++ELLTG +     
Sbjct: 203  V----ADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTV- 257

Query: 1005 PAGINTHTTLN---------MPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPF 1055
                N+   ++          P+ +S  A+ LIQ+LL  +P +RLG G    ++IK H F
Sbjct: 258  DGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLF 317

Query: 1056 FTPVDWAEL 1064
            F  ++W +L
Sbjct: 318  FQKINWDDL 326



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 45/175 (25%), Positives = 79/175 (45%), Gaps = 28/175 (16%)

Query: 912  EMVVALDALHREGIVCRDLNPNNILLNDRG-HIQLTY----FSRWSEVEDS-CDSDAIER 965
            ++V A+  +H  G+V RDL P N+L  D   ++++      F+R    ++    +     
Sbjct: 527  KLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTL 586

Query: 966  MYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-------- 1017
             Y APE+       E+CD WSLG +L+ +L+G+   + H   +   + + +         
Sbjct: 587  HYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDF 646

Query: 1018 -------ECVSEEARSLIQQLLQFNPLERL-------GAGVAGVEDIKSHPFFTP 1058
                   + VS+EA+ LIQ LL  +P +RL          +     + S+P  TP
Sbjct: 647  SFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTP 701



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 19/71 (26%), Positives = 39/71 (54%), Gaps = 4/71 (5%)

Query: 350 LLVMDTRTEQTFILKGLRKSSEYSRNRKTIIP--RCVPNMVCLHKYIISEESVFLVLQHA 407
           L  M    + T + K   K++E++R  + ++   R  P +V LH    +E  + L+L + 
Sbjct: 77  LYAMKVLKKATIVQKA--KTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYI 134

Query: 408 EGGKLWSYISK 418
            GG+L++++S+
Sbjct: 135 NGGELFTHLSQ 145



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 24/90 (26%), Positives = 44/90 (48%), Gaps = 3/90 (3%)

Query: 356 RTEQTFILKGLRKSSEYSRNRK-TIIPRCV--PNMVCLHKYIISEESVFLVLQHAEGGKL 412
           ++ Q F +K + K  E +  ++ T +  C   PN+V LH+    +   FLV++   GG+L
Sbjct: 447 KSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGEL 506

Query: 413 WSYISKFLNRSPEESFDIKEVKKPTLAKVH 442
           +  I K  + S  E+  I       ++ +H
Sbjct: 507 FERIKKKKHFSETEASYIMRKLVSAVSHMH 536



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 25/71 (35%), Positives = 34/71 (47%), Gaps = 4/71 (5%)

Query: 421 NRSPEESFDIKEVKKPTLAKVHLQQPTSS---PQDSSSFESRGSDGGSMLKALPLKSSLT 477
           N+   E F ++ V K  LAK    + TS+    + SSS  S  S   S  K  P K +L 
Sbjct: 723 NKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTK-TLQ 781

Query: 478 PSSQDDSNQED 488
           PS+  DSN  +
Sbjct: 782 PSNPADSNNPE 792


>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
            [Homo sapiens]
          Length = 1388

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 63/183 (34%), Positives = 99/183 (54%), Gaps = 19/183 (10%)

Query: 895  LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954
            L S + +PE   + + AE+V+ALDA+H  G++ RD+ P+N+LL+  GH++L  F    ++
Sbjct: 180  LMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKM 239

Query: 955  EDS----CDSDAIERMYCAPEV----GAITEETEACDWWSLGAVLFELLTGKT------L 1000
            +++    CD+      Y +PEV    G        CDWWS+G  L+E+L G T      L
Sbjct: 240  DETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSL 299

Query: 1001 VECHPAGINTHTTLNMPEC--VSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTP 1058
            V  +   ++   +L  PE   +S+ A++LI   L    + RLG    GVE+I+ HPFF  
Sbjct: 300  VGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREV-RLGRN--GVEEIRQHPFFKN 356

Query: 1059 VDW 1061
              W
Sbjct: 357  DQW 359


>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
          Length = 1711

 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 77/249 (30%), Positives = 121/249 (48%), Gaps = 29/249 (11%)

Query: 836  DTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLAL 895
            + LK  E   F ++ D L   +   +       + E+ L L  D   + +  DL   L L
Sbjct: 111  EMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMD---YYVGGDL---LTL 164

Query: 896  ASRFY--IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE 953
             S+F   +PE   + +  EMV+A+D++H+   V RD+ P+N+LL+  GHI+L  F    +
Sbjct: 165  LSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLK 224

Query: 954  VEDSCDSDAIERM----YCAPEVGAITEE-----TEACDWWSLGAVLFELLTGKT----- 999
            + D     +   +    Y +PE+    E+        CDWWSLG  ++E+L G+T     
Sbjct: 225  MNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAE 284

Query: 1000 -LVECHPAGINTHTTLNMPE---CVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPF 1055
             LVE +   +N       P     VSEEA+ LIQ+L+  +   RLG    G+ED K H F
Sbjct: 285  SLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLI-CSRERRLGQN--GIEDFKKHAF 341

Query: 1056 FTPVDWAEL 1064
            F  ++W  +
Sbjct: 342  FEGLNWENI 350



 Score = 33.9 bits (76), Expect = 0.84
 Identities = 24/102 (23%), Positives = 48/102 (47%), Gaps = 10/102 (9%)

Query: 335 EELKAFRVLG--VIDKVLLVMDTRTEQTFILKGLRK--------SSEYSRNRKTIIPRCV 384
           E+ +  +V+G     +V +V    TE+ + +K L K        ++ +   R  ++    
Sbjct: 74  EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 133

Query: 385 PNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEE 426
             +  LH     E  ++LV+ +  GG L + +SKF ++ PE+
Sbjct: 134 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPED 175


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.131    0.373 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,963,780
Number of Sequences: 37866
Number of extensions: 1980107
Number of successful extensions: 7073
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 315
Number of HSP's successfully gapped in prelim test: 370
Number of HSP's that attempted gapping in prelim test: 5409
Number of HSP's gapped (non-prelim): 1329
length of query: 1066
length of database: 18,247,518
effective HSP length: 113
effective length of query: 953
effective length of database: 13,968,660
effective search space: 13312132980
effective search space used: 13312132980
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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