BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|19923723 ribosomal protein S6 kinase, 52kDa, polypeptide 1 isoform a [Homo sapiens] (1066 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|19923723 ribosomal protein S6 kinase, 52kDa, polypeptide 1 is... 2119 0.0 gi|209915591 ribosomal protein S6 kinase, 52kDa, polypeptide 1 i... 2087 0.0 gi|13899309 ribosomal protein S6 kinase-like 1 [Homo sapiens] 209 9e-54 gi|22547191 sorting nexin 15 isoform A [Homo sapiens] 201 3e-51 gi|46370089 sorting nexin 15 isoform B [Homo sapiens] 163 9e-40 gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 126 1e-28 gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 126 1e-28 gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 122 1e-27 gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 114 4e-25 gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 114 4e-25 gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 113 1e-24 gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 112 1e-24 gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 106 1e-22 gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 104 4e-22 gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 104 4e-22 gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 104 5e-22 gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 99 2e-20 gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s... 99 2e-20 gi|112363080 microtubule associated serine/threonine kinase 2 [H... 97 6e-20 gi|5453974 protein kinase N2 [Homo sapiens] 96 1e-19 gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 96 2e-19 gi|150170729 microtubule associated serine/threonine kinase 3 [H... 96 2e-19 gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 96 2e-19 gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 96 2e-19 gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 96 2e-19 gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 96 2e-19 gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 96 2e-19 gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 96 2e-19 gi|41872583 Rho-associated, coiled-coil containing protein kinas... 96 2e-19 gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 95 3e-19 >gi|19923723 ribosomal protein S6 kinase, 52kDa, polypeptide 1 isoform a [Homo sapiens] Length = 1066 Score = 2119 bits (5490), Expect = 0.0 Identities = 1066/1066 (100%), Positives = 1066/1066 (100%) Query: 1 MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKL 60 MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKL Sbjct: 1 MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKL 60 Query: 61 HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ 120 HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ Sbjct: 61 HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ 120 Query: 121 LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD 180 LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD Sbjct: 121 LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD 180 Query: 181 GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL 240 GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL Sbjct: 181 GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL 240 Query: 241 EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA 300 EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA Sbjct: 241 EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA 300 Query: 301 ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT 360 ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT Sbjct: 301 ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT 360 Query: 361 FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL 420 FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL Sbjct: 361 FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL 420 Query: 421 NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS 480 NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS Sbjct: 421 NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS 480 Query: 481 QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN 540 QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN Sbjct: 481 QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN 540 Query: 541 GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF 600 GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF Sbjct: 541 GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF 600 Query: 601 FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI 660 FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI Sbjct: 601 FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI 660 Query: 661 SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI 720 SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI Sbjct: 661 SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI 720 Query: 721 IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA 780 IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA Sbjct: 721 IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA 780 Query: 781 VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT 840 VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT Sbjct: 781 VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT 840 Query: 841 EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY 900 EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY Sbjct: 841 EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY 900 Query: 901 IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS 960 IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS Sbjct: 901 IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS 960 Query: 961 DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV 1020 DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV Sbjct: 961 DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV 1020 Query: 1021 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR Sbjct: 1021 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066 >gi|209915591 ribosomal protein S6 kinase, 52kDa, polypeptide 1 isoform b [Homo sapiens] Length = 1054 Score = 2087 bits (5407), Expect = 0.0 Identities = 1054/1066 (98%), Positives = 1054/1066 (98%), Gaps = 12/1066 (1%) Query: 1 MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKL 60 MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTAR IIVWKRYSDFKKL Sbjct: 1 MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTAR------------IIVWKRYSDFKKL 48 Query: 61 HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ 120 HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ Sbjct: 49 HKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQ 108 Query: 121 LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD 180 LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD Sbjct: 109 LEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDD 168 Query: 181 GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL 240 GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL Sbjct: 169 GMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYL 228 Query: 241 EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA 300 EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA Sbjct: 229 EKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRA 288 Query: 301 ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT 360 ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT Sbjct: 289 ESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQT 348 Query: 361 FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL 420 FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL Sbjct: 349 FILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFL 408 Query: 421 NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS 480 NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS Sbjct: 409 NRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSS 468 Query: 481 QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN 540 QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN Sbjct: 469 QDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGN 528 Query: 541 GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF 600 GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF Sbjct: 529 GVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEF 588 Query: 601 FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI 660 FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI Sbjct: 589 FRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTI 648 Query: 661 SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI 720 SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI Sbjct: 649 SRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGI 708 Query: 721 IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA 780 IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA Sbjct: 709 IENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAA 768 Query: 781 VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT 840 VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT Sbjct: 769 VDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKT 828 Query: 841 EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY 900 EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY Sbjct: 829 EEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFY 888 Query: 901 IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS 960 IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS Sbjct: 889 IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS 948 Query: 961 DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV 1020 DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV Sbjct: 949 DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV 1008 Query: 1021 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR Sbjct: 1009 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1054 >gi|13899309 ribosomal protein S6 kinase-like 1 [Homo sapiens] Length = 541 Score = 209 bits (533), Expect = 9e-54 Identities = 91/165 (55%), Positives = 125/165 (75%) Query: 901 IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDS 960 + E +++WAAEM+VAL+ALH +G++CRDL+P N+LL+ GHI+LTYF +WSEVE C Sbjct: 353 VREEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLLDQAGHIRLTYFGQWSEVEPQCCG 412 Query: 961 DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECV 1020 +A++ +Y APEVG I+E TEACDWWS G++L+ELLTG L + HP+GI HT L +PE + Sbjct: 413 EAVDNLYSAPEVGGISELTEACDWWSFGSLLYELLTGMALSQSHPSGIQAHTQLQLPEWL 472 Query: 1021 SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELM 1065 S A SL+ +LLQF P RLG G GV +KSHPFF+ + W++L+ Sbjct: 473 SRPAASLLTELLQFEPTRRLGMGEGGVSKLKSHPFFSTIQWSKLV 517 Score = 121 bits (303), Expect = 4e-27 Identities = 73/185 (39%), Positives = 102/185 (55%), Gaps = 28/185 (15%) Query: 232 PKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKR 291 P + KRDYL A I+LAL+++ +DYEAA + Y+ GVD+LL G+ + + RREAVK Sbjct: 42 PDMTKRDYLVDAATQIRLALERDVSEDYEAAFNHYQNGVDVLLRGIHVDPNKERREAVKL 101 Query: 292 RTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLL 351 + +YL RAE I + + RPL + SP+ V L Sbjct: 102 KITKYLRRAEEIFNCH---------------LQRPLSSGASPS-------------AVQL 133 Query: 352 VMDTRTEQTFILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGK 411 V D T TF++K L + SR R TIIP VP M L +Y +SE+S+FL L+H +GG Sbjct: 134 VQDPATGGTFVVKSLPRCHMVSRERLTIIPHGVPYMTKLLRYFVSEDSIFLHLEHVQGGT 193 Query: 412 LWSYI 416 LWS++ Sbjct: 194 LWSHL 198 >gi|22547191 sorting nexin 15 isoform A [Homo sapiens] Length = 342 Score = 201 bits (511), Expect = 3e-51 Identities = 129/334 (38%), Positives = 178/334 (53%), Gaps = 31/334 (9%) Query: 5 RERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKEL 64 R+ D R YTV++P+ HP+GYT YKVTA+ +S+++PEDV+E++VWKRYSDF+KLH +L Sbjct: 3 RQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDVKEVVVWKRYSDFRKLHGDL 62 Query: 65 WQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDF 124 H+NLFR E FP F + VFGRF+ +VIEERR+ AEDLL+F+ +IPAL NS QL++F Sbjct: 63 AYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEF 122 Query: 125 FKGGIINDSSELIGPAEAHSDSLIDT----FPECSTEGFSSDSDLVSLTVDVD------- 173 F+GG + E+ LI T P S + L L V VD Sbjct: 123 FRGGEVTRPLEVSRDLHILPPPLIPTPPPDDPRLSQLLPAERRGLEELEVPVDPPPSSPA 182 Query: 174 --------SLAELDDGMASNQNSPIRTFGLNL----SSDSSALGAVASDSEQSKTEEERE 221 + ++ S P+ L L S + A + +E + E E Sbjct: 183 QEALDLLFNCESTEEASGSPARGPLTEAELALFDPFSKEEGAAPSPTHVAELATMEVESA 242 Query: 222 SRSLFPGSLKPKLGKRD--------YLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLL 273 P + + D YL +A ELI AL+ E+ Y AA YR GV +L Sbjct: 243 RLDQEPWEPGGQEEEEDGEGGPTPAYLSQATELITQALRDEKAGAYAAALQGYRDGVHVL 302 Query: 274 LEGVQGESSPTRREAVKRRTAEYLMRAESISSLY 307 L+GV + P R+E VK++ AEYL RAE I L+ Sbjct: 303 LQGVPSDPLPARQEGVKKKAAEYLKRAEEILRLH 336 >gi|46370089 sorting nexin 15 isoform B [Homo sapiens] Length = 256 Score = 163 bits (412), Expect = 9e-40 Identities = 102/257 (39%), Positives = 144/257 (56%), Gaps = 14/257 (5%) Query: 5 RERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKEL 64 R+ D R YTV++P+ HP+GYT YKVTA+ +S+++PEDV+E++VWKRYSDF+KLH +L Sbjct: 3 RQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDVKEVVVWKRYSDFRKLHGDL 62 Query: 65 WQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDF 124 H+NLFR E FP F + VFGRF+ +VIEERR+ AEDLL+F+ +IPAL NS QL++F Sbjct: 63 AYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEF 122 Query: 125 FKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMAS 184 F+GG E+ P E D I P T L + L EL+ + Sbjct: 123 FRGG------EVTRPLEVSRDLHILPPPLIPTPPPDDPRLSQLLPAERRGLEELEVPVDP 176 Query: 185 NQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEE--------RESRSLFPGSLKPKLGK 236 +SP + L + S A S + TE E +E L K Sbjct: 177 PPSSPAQEALDLLFNCESTEEASGSPARGPLTEAELALFDPFSKEGDPLPARQEGVKKKA 236 Query: 237 RDYLEKAGELIKLALKK 253 +YL++A E+++L L + Sbjct: 237 AEYLKRAEEILRLHLSQ 253 Score = 34.7 bits (78), Expect = 0.49 Identities = 15/30 (50%), Positives = 21/30 (70%) Query: 278 QGESSPTRREAVKRRTAEYLMRAESISSLY 307 +G+ P R+E VK++ AEYL RAE I L+ Sbjct: 221 EGDPLPARQEGVKKKAAEYLKRAEEILRLH 250 >gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 isoform b [Homo sapiens] Length = 741 Score = 126 bits (317), Expect = 1e-28 Identities = 73/180 (40%), Positives = 100/180 (55%), Gaps = 9/180 (5%) Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954 L+ E ++ + AE+ +ALD LH GI+ RDL P NILL++ GHI++T F E Sbjct: 158 LSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEA 217 Query: 955 EDSCDSDAIERM----YCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVEC----HPA 1006 D D A Y APEV T++ DWWS G ++FE+LTG + Sbjct: 218 IDH-DKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETM 276 Query: 1007 GINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066 + L MP+ +S EA+SL++ L + NP RLGAG+ GVE+IK HPFF +DW L R Sbjct: 277 ALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYR 336 Score = 47.0 bits (110), Expect = 1e-04 Identities = 38/144 (26%), Positives = 62/144 (43%), Gaps = 18/144 (12%) Query: 917 LDALHREGIVCRDLNPNNILLNDRG----HIQLTYFSRWSEVEDS---CDSDAIERMYCA 969 +D LH +G+V RDL P+NIL D I++ F ++ + + A Sbjct: 528 MDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVA 587 Query: 970 PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018 PEV ACD WSLG +L+ +L G T P + + Sbjct: 588 PEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWD 647 Query: 1019 CVSEEARSLIQQLLQFNPLERLGA 1042 +S+ A+ ++ ++L +P +RL A Sbjct: 648 SISDAAKDVVSKMLHVDPHQRLTA 671 >gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 isoform a [Homo sapiens] Length = 733 Score = 126 bits (317), Expect = 1e-28 Identities = 73/180 (40%), Positives = 100/180 (55%), Gaps = 9/180 (5%) Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954 L+ E ++ + AE+ +ALD LH GI+ RDL P NILL++ GHI++T F E Sbjct: 150 LSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEA 209 Query: 955 EDSCDSDAIERM----YCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVEC----HPA 1006 D D A Y APEV T++ DWWS G ++FE+LTG + Sbjct: 210 IDH-DKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETM 268 Query: 1007 GINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066 + L MP+ +S EA+SL++ L + NP RLGAG+ GVE+IK HPFF +DW L R Sbjct: 269 ALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYR 328 Score = 47.0 bits (110), Expect = 1e-04 Identities = 38/144 (26%), Positives = 62/144 (43%), Gaps = 18/144 (12%) Query: 917 LDALHREGIVCRDLNPNNILLNDRG----HIQLTYFSRWSEVEDS---CDSDAIERMYCA 969 +D LH +G+V RDL P+NIL D I++ F ++ + + A Sbjct: 520 MDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVA 579 Query: 970 PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018 PEV ACD WSLG +L+ +L G T P + + Sbjct: 580 PEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWD 639 Query: 1019 CVSEEARSLIQQLLQFNPLERLGA 1042 +S+ A+ ++ ++L +P +RL A Sbjct: 640 SISDAAKDVVSKMLHVDPHQRLTA 663 >gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo sapiens] Length = 740 Score = 122 bits (307), Expect = 1e-27 Identities = 76/183 (41%), Positives = 103/183 (56%), Gaps = 15/183 (8%) Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954 L+ E ++ + AE+ +ALD LH GI+ RDL P NILL++ GHI+LT F E Sbjct: 159 LSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKE- 217 Query: 955 EDSCDSDAIERMYC------APEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGI 1008 S D + +C APEV T++ DWWS G ++FE+LTG TL Sbjct: 218 --SIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG-TLPFQGKDRK 274 Query: 1009 NTHTT-----LNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAE 1063 T T L MP+ +S EA+SL++ L + NP RLGAG GVE+IK H FF+ +DW + Sbjct: 275 ETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNK 334 Query: 1064 LMR 1066 L R Sbjct: 335 LYR 337 Score = 50.1 bits (118), Expect = 1e-05 Identities = 46/166 (27%), Positives = 71/166 (42%), Gaps = 25/166 (15%) Query: 917 LDALHREGIVCRDLNPNNILLNDRG------HIQLTYFSRWSEVEDSC-DSDAIERMYCA 969 ++ LH +G+V RDL P+NIL D I F++ E+ + + A Sbjct: 527 VEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVA 586 Query: 970 PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018 PEV ACD WSLG +L+ +LTG T P + Sbjct: 587 PEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWN 646 Query: 1019 CVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAEL 1064 VS+ A+ L+ ++L +P +RL A + + HP+ V W +L Sbjct: 647 SVSDTAKDLVSKMLHVDPHQRLTAAL-----VLRHPWI--VHWDQL 685 >gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform b [Homo sapiens] Length = 744 Score = 114 bits (286), Expect = 4e-25 Identities = 67/179 (37%), Positives = 96/179 (53%), Gaps = 7/179 (3%) Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954 L+ E ++ + AE+ + LD LH GI+ RDL P NILL++ GHI+LT F E Sbjct: 162 LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEA 221 Query: 955 ---EDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVEC----HPAG 1007 E S Y APEV + + DWWS G ++FE+LTG + Sbjct: 222 IDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMT 281 Query: 1008 INTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066 + L MP+ +S EA+SL++ L + NP RLG+G G E+IK H F++ +DW +L R Sbjct: 282 LILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYR 340 Score = 52.0 bits (123), Expect = 3e-06 Identities = 45/162 (27%), Positives = 69/162 (42%), Gaps = 23/162 (14%) Query: 917 LDALHREGIVCRDLNPNNILLNDRG------HIQLTYFSRWSEVEDSC-DSDAIERMYCA 969 ++ LH +G+V RDL P+NIL D I F++ E+ + + A Sbjct: 532 VEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA 591 Query: 970 PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018 PEV E CD WSLG +L+ +L G T P+ + Sbjct: 592 PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 651 Query: 1019 CVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVD 1060 VSE A+ L+ ++L +P +RL A + + HP+ T D Sbjct: 652 TVSETAKDLVSKMLHVDPHQRLTA-----KQVLQHPWVTQKD 688 >gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform a [Homo sapiens] Length = 735 Score = 114 bits (286), Expect = 4e-25 Identities = 67/179 (37%), Positives = 96/179 (53%), Gaps = 7/179 (3%) Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954 L+ E ++ + AE+ + LD LH GI+ RDL P NILL++ GHI+LT F E Sbjct: 153 LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEA 212 Query: 955 ---EDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVEC----HPAG 1007 E S Y APEV + + DWWS G ++FE+LTG + Sbjct: 213 IDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMT 272 Query: 1008 INTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066 + L MP+ +S EA+SL++ L + NP RLG+G G E+IK H F++ +DW +L R Sbjct: 273 LILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYR 331 Score = 52.0 bits (123), Expect = 3e-06 Identities = 45/162 (27%), Positives = 69/162 (42%), Gaps = 23/162 (14%) Query: 917 LDALHREGIVCRDLNPNNILLNDRG------HIQLTYFSRWSEVEDSC-DSDAIERMYCA 969 ++ LH +G+V RDL P+NIL D I F++ E+ + + A Sbjct: 523 VEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA 582 Query: 970 PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018 PEV E CD WSLG +L+ +L G T P+ + Sbjct: 583 PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 642 Query: 1019 CVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVD 1060 VSE A+ L+ ++L +P +RL A + + HP+ T D Sbjct: 643 TVSETAKDLVSKMLHVDPHQRLTA-----KQVLQHPWVTQKD 679 >gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] Length = 745 Score = 113 bits (282), Expect = 1e-24 Identities = 79/218 (36%), Positives = 119/218 (54%), Gaps = 38/218 (17%) Query: 867 ETKGESGLVLE----GDKEIHQIFEDLDKKLALASRFYIPEGCIQRWAAEMVVALDALHR 922 +T+G+ L+L+ GD +F L K++ E ++ + AE+ +ALD LH+ Sbjct: 143 QTEGKLYLILDFLRGGD-----VFTRLSKEVLFT------EEDVKFYLAELALALDHLHQ 191 Query: 923 EGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYC------APEVGAIT 976 GIV RDL P NILL++ GHI+LT F E S D + +C APEV Sbjct: 192 LGIVYRDLKPENILLDEIGHIKLTDFGLSKE---SVDQEKKAYSFCGTVEYMAPEVVNRR 248 Query: 977 EETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLN--------MPECVSEEARSLI 1028 +++ DWWS G ++FE+LTG + G + + T+N MP+ +S EA+SL+ Sbjct: 249 GHSQSADWWSYGVLMFEMLTGTLPFQ----GKDRNETMNMILKAKLGMPQFLSAEAQSLL 304 Query: 1029 QQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR 1066 + L + NP RLG+ GVE+IK H FF +DW +L + Sbjct: 305 RMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYK 340 Score = 46.6 bits (109), Expect = 1e-04 Identities = 43/162 (26%), Positives = 66/162 (40%), Gaps = 23/162 (14%) Query: 917 LDALHREGIVCRDLNPNNILLNDRG----HIQLTYFSRWSEVEDSCD---SDAIERMYCA 969 +D LH +G+V RDL P+NIL D I++ F ++ + + A Sbjct: 531 VDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVA 590 Query: 970 PEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-----------E 1018 PEV ACD WSLG + + +L G T P L + + Sbjct: 591 PEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWD 650 Query: 1019 CVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVD 1060 +S+ A+ L+ +L +P +R A E I H + T D Sbjct: 651 NISDGAKDLLSHMLHMDPHQRYTA-----EQILKHSWITHRD 687 >gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo sapiens] Length = 525 Score = 112 bits (281), Expect = 1e-24 Identities = 63/171 (36%), Positives = 97/171 (56%), Gaps = 21/171 (12%) Query: 909 WAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYC 968 + AE+ +AL LH++GI+ RDL P NI+LN +GH++LT F E S + +C Sbjct: 198 YLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKE---SIHDGTVTHTFC 254 Query: 969 ------APEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTT--------L 1014 APE+ + A DWWSLGA+++++LTG G N T L Sbjct: 255 GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPF----TGENRKKTIDKILKCKL 310 Query: 1015 NMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELM 1065 N+P +++EAR L+++LL+ N RLGAG ++++HPFF ++W EL+ Sbjct: 311 NLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELL 361 >gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo sapiens] Length = 482 Score = 106 bits (265), Expect = 1e-22 Identities = 58/171 (33%), Positives = 94/171 (54%), Gaps = 21/171 (12%) Query: 909 WAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYC 968 + AE+ +AL LH +GI+ RDL P NI+L+ +GHI+LT F E S A+ +C Sbjct: 174 YLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKE---SIHEGAVTHTFC 230 Query: 969 ------APEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLN------- 1015 APE+ + A DWWSLGA+++++LTG N T++ Sbjct: 231 GTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAE----NRKKTMDKIIRGKL 286 Query: 1016 -MPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELM 1065 +P ++ +AR L+++ L+ NP +R+G G D++ HPFF ++W +L+ Sbjct: 287 ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLL 337 >gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform b [Homo sapiens] Length = 766 Score = 104 bits (260), Expect = 4e-22 Identities = 67/192 (34%), Positives = 100/192 (52%), Gaps = 31/192 (16%) Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSR---- 950 L R Y E ++ + E+V+AL+ LH+ GI+ RDL N+LL+ GHI LT F Sbjct: 127 LYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEF 186 Query: 951 WSEVEDSCDSDAIERMYCAPE-VGAITEETEACDWWSLGAVLFELLTG------------ 997 +E ++ S Y APE + + T +A DWWSLG +LFELLTG Sbjct: 187 LTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNT 246 Query: 998 -----KTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKS 1052 + +++C P P + A+ L+Q+LL +P +RLGAG G +++++ Sbjct: 247 QAEVSRRILKCSPP---------FPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRN 297 Query: 1053 HPFFTPVDWAEL 1064 HPFF +DW L Sbjct: 298 HPFFQGLDWVAL 309 Score = 50.1 bits (118), Expect = 1e-05 Identities = 46/156 (29%), Positives = 69/156 (44%), Gaps = 33/156 (21%) Query: 913 MVVALDALHRE-GIVCRDLNPNNIL-----------LNDRGHIQLTYFSRWSEVEDSCDS 960 +V A+ +H E G+V RDL P NIL + D G +L S ++ C Sbjct: 507 LVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPC-- 564 Query: 961 DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPEC- 1019 Y APE+ A E+CD WSLG +L+ +L+G+ + +G + C Sbjct: 565 --FTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQ-GASGQGGQSQAAEIMCK 621 Query: 1020 ---------------VSEEARSLIQQLLQFNPLERL 1040 VSEEA+ L++ LL +P +RL Sbjct: 622 IREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRL 657 Score = 30.4 bits (67), Expect = 9.3 Identities = 23/75 (30%), Positives = 36/75 (48%), Gaps = 3/75 (4%) Query: 359 QTFILKGLRKSSEYSRNRKTIIPRCV---PNMVCLHKYIISEESVFLVLQHAEGGKLWSY 415 Q F +K L + E + R+ R PN+V LH+ + +LVL+ GG+L + Sbjct: 429 QEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEH 488 Query: 416 ISKFLNRSPEESFDI 430 I K + S E+ I Sbjct: 489 IRKKRHFSESEASQI 503 >gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform a [Homo sapiens] Length = 772 Score = 104 bits (260), Expect = 4e-22 Identities = 67/192 (34%), Positives = 100/192 (52%), Gaps = 31/192 (16%) Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSR---- 950 L R Y E ++ + E+V+AL+ LH+ GI+ RDL N+LL+ GHI LT F Sbjct: 127 LYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEF 186 Query: 951 WSEVEDSCDSDAIERMYCAPE-VGAITEETEACDWWSLGAVLFELLTG------------ 997 +E ++ S Y APE + + T +A DWWSLG +LFELLTG Sbjct: 187 LTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNT 246 Query: 998 -----KTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKS 1052 + +++C P P + A+ L+Q+LL +P +RLGAG G +++++ Sbjct: 247 QAEVSRRILKCSPP---------FPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRN 297 Query: 1053 HPFFTPVDWAEL 1064 HPFF +DW L Sbjct: 298 HPFFQGLDWVAL 309 Score = 50.1 bits (118), Expect = 1e-05 Identities = 46/156 (29%), Positives = 69/156 (44%), Gaps = 33/156 (21%) Query: 913 MVVALDALHRE-GIVCRDLNPNNIL-----------LNDRGHIQLTYFSRWSEVEDSCDS 960 +V A+ +H E G+V RDL P NIL + D G +L S ++ C Sbjct: 513 LVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPC-- 570 Query: 961 DAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPEC- 1019 Y APE+ A E+CD WSLG +L+ +L+G+ + +G + C Sbjct: 571 --FTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQ-GASGQGGQSQAAEIMCK 627 Query: 1020 ---------------VSEEARSLIQQLLQFNPLERL 1040 VSEEA+ L++ LL +P +RL Sbjct: 628 IREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRL 663 Score = 30.4 bits (67), Expect = 9.3 Identities = 23/75 (30%), Positives = 36/75 (48%), Gaps = 3/75 (4%) Query: 359 QTFILKGLRKSSEYSRNRKTIIPRCV---PNMVCLHKYIISEESVFLVLQHAEGGKLWSY 415 Q F +K L + E + R+ R PN+V LH+ + +LVL+ GG+L + Sbjct: 435 QEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEH 494 Query: 416 ISKFLNRSPEESFDI 430 I K + S E+ I Sbjct: 495 IRKKRHFSESEASQI 509 >gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo sapiens] Length = 1551 Score = 104 bits (259), Expect = 5e-22 Identities = 85/247 (34%), Positives = 122/247 (49%), Gaps = 41/247 (16%) Query: 852 DLAKEEPTSLF--QRDSETKGESGLVLEGDKEIHQIFEDLD------------KKLALAS 897 ++ K T+ F +RD KG+S V +H F+D + L L S Sbjct: 106 EMLKRAETACFREERDVLVKGDSRWVTT----LHYAFQDEEYLYLVMDYYAGGDLLTLLS 161 Query: 898 RFY--IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVE 955 RF +P Q + AEMV+A+ +LH+ G V RD+ P+N+LL+ GHI+L F + Sbjct: 162 RFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLN 221 Query: 956 DSCDSDAIERM----YCAPEVGAITEETEA-----CDWWSLGAVLFELLTGKT------L 1000 + D+ + Y +PE+ EE + CDWWSLG +ELL G+T L Sbjct: 222 TNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESL 281 Query: 1001 VECHPAGINTHTTLNMPECVSE---EARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFT 1057 VE + +N L P V + A+ LI+QLL ERLG G G++D ++HPFF Sbjct: 282 VETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLL-CRQEERLGRG--GLDDFRNHPFFE 338 Query: 1058 PVDWAEL 1064 VDW L Sbjct: 339 GVDWERL 345 Score = 35.4 bits (80), Expect = 0.29 Identities = 27/107 (25%), Positives = 49/107 (45%), Gaps = 10/107 (9%) Query: 330 LRSPAEELKAFRVLG--VIDKVLLVMDTRTEQTFILKGLRK--------SSEYSRNRKTI 379 LR ++ + +V+G +V +V T Q F +K L K ++ + R + Sbjct: 64 LRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVL 123 Query: 380 IPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEE 426 + + LH EE ++LV+ + GG L + +S+F +R P E Sbjct: 124 VKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPE 170 >gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo sapiens] Length = 1719 Score = 99.4 bits (246), Expect = 2e-20 Identities = 76/247 (30%), Positives = 123/247 (49%), Gaps = 47/247 (19%) Query: 852 DLAKEEPTSLFQRDSETKGESGLVLEGDKE----IHQIFEDLDKKLALASRFYI------ 901 ++ K T+ F+ + + +++ GD + +H F+D D L L +Y+ Sbjct: 112 EMLKRAETACFREERD------VLVNGDNKWITTLHYAFQD-DNNLYLVMDYYVGGDLLT 164 Query: 902 ---------PEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYF-SRW 951 PE + + AEMV+A+D++H+ V RD+ P+NIL++ GHI+L F S Sbjct: 165 LLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCL 224 Query: 952 SEVEDSCDSDAI---ERMYCAPEVGAITEETEA-----CDWWSLGAVLFELLTGKT---- 999 +ED ++ Y +PE+ E+ + CDWWSLG ++E+L G+T Sbjct: 225 KLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYA 284 Query: 1000 --LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHP 1054 LVE + +N P VSE A+ LI++L+ + RLG G+ED K HP Sbjct: 285 ESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLI-CSREHRLGQN--GIEDFKKHP 341 Query: 1055 FFTPVDW 1061 FF+ +DW Sbjct: 342 FFSGIDW 348 Score = 33.1 bits (74), Expect = 1.4 Identities = 36/156 (23%), Positives = 65/156 (41%), Gaps = 33/156 (21%) Query: 281 SSPTRREAVKRRTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAF 340 +SP RRE + EYL + KP V Q +R E+ + Sbjct: 44 NSPLRRE---KNILEYLE--------WAKPFTSKVKQ------------MRLHREDFEIL 80 Query: 341 RVLG--VIDKVLLVMDTRTEQTFILKGLRK--------SSEYSRNRKTIIPRCVPNMVCL 390 +V+G +V +V ++ F +K L K ++ + R ++ + L Sbjct: 81 KVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTL 140 Query: 391 HKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEE 426 H + +++LV+ + GG L + +SKF +R PE+ Sbjct: 141 HYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPED 176 >gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo sapiens] Length = 1638 Score = 99.4 bits (246), Expect = 2e-20 Identities = 76/247 (30%), Positives = 123/247 (49%), Gaps = 47/247 (19%) Query: 852 DLAKEEPTSLFQRDSETKGESGLVLEGDKE----IHQIFEDLDKKLALASRFYI------ 901 ++ K T+ F+ + + +++ GD + +H F+D D L L +Y+ Sbjct: 112 EMLKRAETACFREERD------VLVNGDNKWITTLHYAFQD-DNNLYLVMDYYVGGDLLT 164 Query: 902 ---------PEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYF-SRW 951 PE + + AEMV+A+D++H+ V RD+ P+NIL++ GHI+L F S Sbjct: 165 LLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCL 224 Query: 952 SEVEDSCDSDAI---ERMYCAPEVGAITEETEA-----CDWWSLGAVLFELLTGKT---- 999 +ED ++ Y +PE+ E+ + CDWWSLG ++E+L G+T Sbjct: 225 KLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYA 284 Query: 1000 --LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHP 1054 LVE + +N P VSE A+ LI++L+ + RLG G+ED K HP Sbjct: 285 ESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLI-CSREHRLGQN--GIEDFKKHP 341 Query: 1055 FFTPVDW 1061 FF+ +DW Sbjct: 342 FFSGIDW 348 Score = 33.1 bits (74), Expect = 1.4 Identities = 36/156 (23%), Positives = 65/156 (41%), Gaps = 33/156 (21%) Query: 281 SSPTRREAVKRRTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAF 340 +SP RRE + EYL + KP V Q +R E+ + Sbjct: 44 NSPLRRE---KNILEYLE--------WAKPFTSKVKQ------------MRLHREDFEIL 80 Query: 341 RVLG--VIDKVLLVMDTRTEQTFILKGLRK--------SSEYSRNRKTIIPRCVPNMVCL 390 +V+G +V +V ++ F +K L K ++ + R ++ + L Sbjct: 81 KVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTL 140 Query: 391 HKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEE 426 H + +++LV+ + GG L + +SKF +R PE+ Sbjct: 141 HYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPED 176 >gi|112363080 microtubule associated serine/threonine kinase 2 [Homo sapiens] Length = 1798 Score = 97.4 bits (241), Expect = 6e-20 Identities = 94/323 (29%), Positives = 140/323 (43%), Gaps = 48/323 (14%) Query: 785 SSGDMSLLPSSDPKFQGLGV-VESAVTANNTE-ESLFRICSPLSGANEYIASTDTLKTEE 842 SS D P +D +G G + S T + + E++ I + GA + T + Sbjct: 480 SSCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFA 539 Query: 843 VLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEG----DKEIH-----QIFEDLDKKL 893 + Q L + + +RD T E+ V+ D + H + E D Sbjct: 540 MKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCAT 599 Query: 894 ALASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFS---- 949 L + +P ++ + AE V+AL+ LH GIV RDL P+N+L+ GHI+LT F Sbjct: 600 LLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKI 659 Query: 950 -----RWSEVEDSCDSDAIERM---------YCAPEVGAITEETEACDWWSLGAVLFELL 995 + E + DA E + Y APEV + DWW++G +L+E L Sbjct: 660 GLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFL 719 Query: 996 TGKTLVECHPAGINTHTTL------------NMPECVSEEARSLIQQLLQFNPLERLGAG 1043 G C P +T L E + +A+ L +LL NPLERLG G Sbjct: 720 VG-----CVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTG 774 Query: 1044 VAGVEDIKSHPFFTPVDWAELMR 1066 A ++K HPFFT +DW L+R Sbjct: 775 SA--YEVKQHPFFTGLDWTGLLR 795 >gi|5453974 protein kinase N2 [Homo sapiens] Length = 984 Score = 96.3 bits (238), Expect = 1e-19 Identities = 59/166 (35%), Positives = 88/166 (53%), Gaps = 11/166 (6%) Query: 909 WAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE---VEDSCDSDAIER 965 +AA +V+ L LH IV RDL +N+LL+ G +++ F E D + Sbjct: 762 YAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTP 821 Query: 966 MYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLV------ECHPAGINTHTTLNMPEC 1019 + APEV T T A DWW LG +++E+L G++ E + +N + P Sbjct: 822 EFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDE--VRYPRF 879 Query: 1020 VSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELM 1065 +S EA S++++LL+ NP RLGA ED+K HPFF +DW+ LM Sbjct: 880 LSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALM 925 >gi|45120119 microtubule associated serine/threonine kinase 1 [Homo sapiens] Length = 1570 Score = 95.9 bits (237), Expect = 2e-19 Identities = 93/328 (28%), Positives = 137/328 (41%), Gaps = 47/328 (14%) Query: 778 VAAVDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDT 837 V ++ SG S P D +G N +++ I + GA + DT Sbjct: 338 VVHLEEQDSGG-SNTPEQDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDT 396 Query: 838 LKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVL------EGDKEIHQIFEDL-- 889 + + Q L + + +RD T E+ V+ E + + + E + Sbjct: 397 RQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEG 456 Query: 890 -DKKLALASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYF 948 D L + +P + + AE V+AL+ LH GIV RDL P+N+L+ GHI+LT F Sbjct: 457 GDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDF 516 Query: 949 S---------RWSEVEDSCDSDAIERM---------YCAPEVGAITEETEACDWWSLGAV 990 + E + DA E + Y APEV + DWW++G + Sbjct: 517 GLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGII 576 Query: 991 LFELLTGKTLVECHPAGINTHTTL------------NMPECVSEEARSLIQQLLQFNPLE 1038 L+E L G C P +T L E + EA+ LI LLQ NPL Sbjct: 577 LYEFLVG-----CVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLV 631 Query: 1039 RLGAGVAGVEDIKSHPFFTPVDWAELMR 1066 RLGAG G ++K H FF +DW L+R Sbjct: 632 RLGAG--GAFEVKQHSFFRDLDWTGLLR 657 >gi|150170729 microtubule associated serine/threonine kinase 3 [Homo sapiens] Length = 1309 Score = 95.9 bits (237), Expect = 2e-19 Identities = 68/196 (34%), Positives = 96/196 (48%), Gaps = 37/196 (18%) Query: 901 IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFS---------RW 951 +P + + AE V+AL+ LH GIV RDL P+N+L+ GHI+LT F Sbjct: 462 LPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMAT 521 Query: 952 SEVEDSCDSDAIERM---------YCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVE 1002 + E + DA E + Y APEV + DWW++G VL+E L G Sbjct: 522 NLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVG----- 576 Query: 1003 CHPAGINTHTTL------------NMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDI 1050 C P +T L E + +A+ LI +LL+ +PL+RLG G G ++ Sbjct: 577 CVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTG--GTHEV 634 Query: 1051 KSHPFFTPVDWAELMR 1066 K HPFF +DWA L+R Sbjct: 635 KQHPFFLALDWAGLLR 650 >gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo sapiens] Length = 639 Score = 95.5 bits (236), Expect = 2e-19 Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 37/251 (14%) Query: 836 DTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLAL 895 D LK EV F ++ D L + + Q + E+ L L + + + DL L L Sbjct: 116 DMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME---YYVGGDL---LTL 169 Query: 896 ASRF--YIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE 953 S+F IP + + AE+V+A+D++HR G V RD+ P+NILL+ GHI+L F + Sbjct: 170 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 229 Query: 954 VE--------------DSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKT 999 + D + ++ + P G+ E CDWW+LG +E+ G+T Sbjct: 230 LRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPE---CDWWALGVFAYEMFYGQT 286 Query: 1000 ------LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDI 1050 E + ++ L++P E V EEAR IQ+LL P RLG G AG D Sbjct: 287 PFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAG--DF 343 Query: 1051 KSHPFFTPVDW 1061 ++HPFF +DW Sbjct: 344 RTHPFFFGLDW 354 Score = 36.6 bits (83), Expect = 0.13 Identities = 32/133 (24%), Positives = 58/133 (43%), Gaps = 10/133 (7%) Query: 304 SSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLG--VIDKVLLVMDTRTEQTF 361 S+L G P+ + PP L +R ++ + +V+G +V +V +T Q + Sbjct: 48 SALSGDPRFFSPTTPPAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVY 107 Query: 362 ILKGLRK--------SSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLW 413 +K + K S + R ++ + LH E ++LV+++ GG L Sbjct: 108 AMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLL 167 Query: 414 SYISKFLNRSPEE 426 + +SKF R P E Sbjct: 168 TLLSKFGERIPAE 180 >gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo sapiens] Length = 625 Score = 95.5 bits (236), Expect = 2e-19 Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 37/251 (14%) Query: 836 DTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLAL 895 D LK EV F ++ D L + + Q + E+ L L + + + DL L L Sbjct: 106 DMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME---YYVGGDL---LTL 159 Query: 896 ASRF--YIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE 953 S+F IP + + AE+V+A+D++HR G V RD+ P+NILL+ GHI+L F + Sbjct: 160 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219 Query: 954 VE--------------DSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKT 999 + D + ++ + P G+ E CDWW+LG +E+ G+T Sbjct: 220 LRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPE---CDWWALGVFAYEMFYGQT 276 Query: 1000 ------LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDI 1050 E + ++ L++P E V EEAR IQ+LL P RLG G AG D Sbjct: 277 PFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAG--DF 333 Query: 1051 KSHPFFTPVDW 1061 ++HPFF +DW Sbjct: 334 RTHPFFFGLDW 344 >gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo sapiens] Length = 624 Score = 95.5 bits (236), Expect = 2e-19 Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 37/251 (14%) Query: 836 DTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLAL 895 D LK EV F ++ D L + + Q + E+ L L + + + DL L L Sbjct: 106 DMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME---YYVGGDL---LTL 159 Query: 896 ASRF--YIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE 953 S+F IP + + AE+V+A+D++HR G V RD+ P+NILL+ GHI+L F + Sbjct: 160 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219 Query: 954 VE--------------DSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKT 999 + D + ++ + P G+ E CDWW+LG +E+ G+T Sbjct: 220 LRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPE---CDWWALGVFAYEMFYGQT 276 Query: 1000 ------LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDI 1050 E + ++ L++P E V EEAR IQ+LL P RLG G AG D Sbjct: 277 PFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAG--DF 333 Query: 1051 KSHPFFTPVDW 1061 ++HPFF +DW Sbjct: 334 RTHPFFFGLDW 344 >gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sapiens] Length = 629 Score = 95.5 bits (236), Expect = 2e-19 Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 37/251 (14%) Query: 836 DTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLAL 895 D LK EV F ++ D L + + Q + E+ L L + + + DL L L Sbjct: 106 DMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME---YYVGGDL---LTL 159 Query: 896 ASRF--YIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE 953 S+F IP + + AE+V+A+D++HR G V RD+ P+NILL+ GHI+L F + Sbjct: 160 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219 Query: 954 VE--------------DSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKT 999 + D + ++ + P G+ E CDWW+LG +E+ G+T Sbjct: 220 LRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPE---CDWWALGVFAYEMFYGQT 276 Query: 1000 ------LVECHPAGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDI 1050 E + ++ L++P E V EEAR IQ+LL P RLG G AG D Sbjct: 277 PFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAG--DF 333 Query: 1051 KSHPFFTPVDW 1061 ++HPFF +DW Sbjct: 334 RTHPFFFGLDW 344 >gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b [Homo sapiens] Length = 549 Score = 95.5 bits (236), Expect = 2e-19 Identities = 64/189 (33%), Positives = 98/189 (51%), Gaps = 24/189 (12%) Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954 L+ R E +Q + E+V+AL+ LH+ GI+ RD+ NILL+ GH+ LT F E Sbjct: 143 LSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEF 202 Query: 955 EDSCDSDAIERM--------YCAPEV--GAITEETEACDWWSLGAVLFELLTGKTLVECH 1004 +D ER Y AP++ G + +A DWWSLG +++ELLTG + Sbjct: 203 V----ADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTV- 257 Query: 1005 PAGINTHTTLN---------MPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPF 1055 N+ ++ P+ +S A+ LIQ+LL +P +RLG G ++IK H F Sbjct: 258 DGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLF 317 Query: 1056 FTPVDWAEL 1064 F ++W +L Sbjct: 318 FQKINWDDL 326 Score = 32.7 bits (73), Expect = 1.9 Identities = 19/71 (26%), Positives = 39/71 (54%), Gaps = 4/71 (5%) Query: 350 LLVMDTRTEQTFILKGLRKSSEYSRNRKTIIP--RCVPNMVCLHKYIISEESVFLVLQHA 407 L M + T + K K++E++R + ++ R P +V LH +E + L+L + Sbjct: 77 LYAMKVLKKATIVQKA--KTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYI 134 Query: 408 EGGKLWSYISK 418 GG+L++++S+ Sbjct: 135 NGGELFTHLSQ 145 Score = 32.7 bits (73), Expect = 1.9 Identities = 24/90 (26%), Positives = 44/90 (48%), Gaps = 3/90 (3%) Query: 356 RTEQTFILKGLRKSSEYSRNRK-TIIPRCV--PNMVCLHKYIISEESVFLVLQHAEGGKL 412 ++ Q F +K + K E + ++ T + C PN+V LH+ + FLV++ GG+L Sbjct: 447 KSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGEL 506 Query: 413 WSYISKFLNRSPEESFDIKEVKKPTLAKVH 442 + I K + S E+ I ++ +H Sbjct: 507 FERIKKKKHFSETEASYIMRKLVSAVSHMH 536 >gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a [Homo sapiens] Length = 802 Score = 95.5 bits (236), Expect = 2e-19 Identities = 64/189 (33%), Positives = 98/189 (51%), Gaps = 24/189 (12%) Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954 L+ R E +Q + E+V+AL+ LH+ GI+ RD+ NILL+ GH+ LT F E Sbjct: 143 LSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEF 202 Query: 955 EDSCDSDAIERM--------YCAPEV--GAITEETEACDWWSLGAVLFELLTGKTLVECH 1004 +D ER Y AP++ G + +A DWWSLG +++ELLTG + Sbjct: 203 V----ADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTV- 257 Query: 1005 PAGINTHTTLN---------MPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPF 1055 N+ ++ P+ +S A+ LIQ+LL +P +RLG G ++IK H F Sbjct: 258 DGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLF 317 Query: 1056 FTPVDWAEL 1064 F ++W +L Sbjct: 318 FQKINWDDL 326 Score = 58.2 bits (139), Expect = 4e-08 Identities = 45/175 (25%), Positives = 79/175 (45%), Gaps = 28/175 (16%) Query: 912 EMVVALDALHREGIVCRDLNPNNILLNDRG-HIQLTY----FSRWSEVEDS-CDSDAIER 965 ++V A+ +H G+V RDL P N+L D ++++ F+R ++ + Sbjct: 527 KLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTL 586 Query: 966 MYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP-------- 1017 Y APE+ E+CD WSLG +L+ +L+G+ + H + + + + Sbjct: 587 HYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDF 646 Query: 1018 -------ECVSEEARSLIQQLLQFNPLERL-------GAGVAGVEDIKSHPFFTP 1058 + VS+EA+ LIQ LL +P +RL + + S+P TP Sbjct: 647 SFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTP 701 Score = 32.7 bits (73), Expect = 1.9 Identities = 19/71 (26%), Positives = 39/71 (54%), Gaps = 4/71 (5%) Query: 350 LLVMDTRTEQTFILKGLRKSSEYSRNRKTIIP--RCVPNMVCLHKYIISEESVFLVLQHA 407 L M + T + K K++E++R + ++ R P +V LH +E + L+L + Sbjct: 77 LYAMKVLKKATIVQKA--KTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYI 134 Query: 408 EGGKLWSYISK 418 GG+L++++S+ Sbjct: 135 NGGELFTHLSQ 145 Score = 32.7 bits (73), Expect = 1.9 Identities = 24/90 (26%), Positives = 44/90 (48%), Gaps = 3/90 (3%) Query: 356 RTEQTFILKGLRKSSEYSRNRK-TIIPRCV--PNMVCLHKYIISEESVFLVLQHAEGGKL 412 ++ Q F +K + K E + ++ T + C PN+V LH+ + FLV++ GG+L Sbjct: 447 KSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGEL 506 Query: 413 WSYISKFLNRSPEESFDIKEVKKPTLAKVH 442 + I K + S E+ I ++ +H Sbjct: 507 FERIKKKKHFSETEASYIMRKLVSAVSHMH 536 Score = 32.3 bits (72), Expect = 2.4 Identities = 25/71 (35%), Positives = 34/71 (47%), Gaps = 4/71 (5%) Query: 421 NRSPEESFDIKEVKKPTLAKVHLQQPTSS---PQDSSSFESRGSDGGSMLKALPLKSSLT 477 N+ E F ++ V K LAK + TS+ + SSS S S S K P K +L Sbjct: 723 NKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTK-TLQ 781 Query: 478 PSSQDDSNQED 488 PS+ DSN + Sbjct: 782 PSNPADSNNPE 792 >gi|41872583 Rho-associated, coiled-coil containing protein kinase 2 [Homo sapiens] Length = 1388 Score = 95.5 bits (236), Expect = 2e-19 Identities = 63/183 (34%), Positives = 99/183 (54%), Gaps = 19/183 (10%) Query: 895 LASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEV 954 L S + +PE + + AE+V+ALDA+H G++ RD+ P+N+LL+ GH++L F ++ Sbjct: 180 LMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKM 239 Query: 955 EDS----CDSDAIERMYCAPEV----GAITEETEACDWWSLGAVLFELLTGKT------L 1000 +++ CD+ Y +PEV G CDWWS+G L+E+L G T L Sbjct: 240 DETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSL 299 Query: 1001 VECHPAGINTHTTLNMPEC--VSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTP 1058 V + ++ +L PE +S+ A++LI L + RLG GVE+I+ HPFF Sbjct: 300 VGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREV-RLGRN--GVEEIRQHPFFKN 356 Query: 1059 VDW 1061 W Sbjct: 357 DQW 359 >gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] Length = 1711 Score = 95.1 bits (235), Expect = 3e-19 Identities = 77/249 (30%), Positives = 121/249 (48%), Gaps = 29/249 (11%) Query: 836 DTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLAL 895 + LK E F ++ D L + + + E+ L L D + + DL L L Sbjct: 111 EMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMD---YYVGGDL---LTL 164 Query: 896 ASRFY--IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSE 953 S+F +PE + + EMV+A+D++H+ V RD+ P+N+LL+ GHI+L F + Sbjct: 165 LSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLK 224 Query: 954 VEDSCDSDAIERM----YCAPEVGAITEE-----TEACDWWSLGAVLFELLTGKT----- 999 + D + + Y +PE+ E+ CDWWSLG ++E+L G+T Sbjct: 225 MNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAE 284 Query: 1000 -LVECHPAGINTHTTLNMPE---CVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPF 1055 LVE + +N P VSEEA+ LIQ+L+ + RLG G+ED K H F Sbjct: 285 SLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLI-CSRERRLGQN--GIEDFKKHAF 341 Query: 1056 FTPVDWAEL 1064 F ++W + Sbjct: 342 FEGLNWENI 350 Score = 33.9 bits (76), Expect = 0.84 Identities = 24/102 (23%), Positives = 48/102 (47%), Gaps = 10/102 (9%) Query: 335 EELKAFRVLG--VIDKVLLVMDTRTEQTFILKGLRK--------SSEYSRNRKTIIPRCV 384 E+ + +V+G +V +V TE+ + +K L K ++ + R ++ Sbjct: 74 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 133 Query: 385 PNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEE 426 + LH E ++LV+ + GG L + +SKF ++ PE+ Sbjct: 134 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPED 175 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.313 0.131 0.373 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 41,963,780 Number of Sequences: 37866 Number of extensions: 1980107 Number of successful extensions: 7073 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 315 Number of HSP's successfully gapped in prelim test: 370 Number of HSP's that attempted gapping in prelim test: 5409 Number of HSP's gapped (non-prelim): 1329 length of query: 1066 length of database: 18,247,518 effective HSP length: 113 effective length of query: 953 effective length of database: 13,968,660 effective search space: 13312132980 effective search space used: 13312132980 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.