Guide to the Human Genome
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Search of human proteins with 197313732

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|197313732 pleckstrin homology-like domain, family B, member
2 isoform a [Homo sapiens]
         (1253 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|197313732 pleckstrin homology-like domain, family B, member 2...  2467   0.0  
gi|197313730 pleckstrin homology-like domain, family B, member 2...  2467   0.0  
gi|197313728 pleckstrin homology-like domain, family B, member 2...  2364   0.0  
gi|21955172 pleckstrin homology-like domain, family B, member 2 ...  2364   0.0  
gi|221219026 pleckstrin homology-like domain, family B, member 1...   625   e-179
gi|221219024 pleckstrin homology-like domain, family B, member 1...   620   e-177
gi|38424073 pleckstrin homology-like domain, family B, member 1 ...   620   e-177
gi|157266264 pleckstrin homology-like domain, family B, member 3...   201   5e-51
gi|21735548 centrosomal protein 2 [Homo sapiens]                       67   1e-10
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                67   1e-10
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     66   2e-10
gi|115511012 coiled-coil domain containing 136 [Homo sapiens]          66   2e-10
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             65   3e-10
gi|41872583 Rho-associated, coiled-coil containing protein kinas...    65   4e-10
gi|71061468 centromere protein E [Homo sapiens]                        65   4e-10
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom...    64   7e-10
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom...    64   7e-10
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    64   1e-09
gi|38044112 restin isoform b [Homo sapiens]                            62   3e-09
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    62   3e-09
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     62   4e-09
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...    62   4e-09
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         61   6e-09
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         61   6e-09
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    61   6e-09
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    61   6e-09
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]                    61   6e-09
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...    60   1e-08
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]    60   1e-08
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    60   2e-08

>gi|197313732 pleckstrin homology-like domain, family B, member 2
            isoform a [Homo sapiens]
          Length = 1253

 Score = 2467 bits (6395), Expect = 0.0
 Identities = 1253/1253 (100%), Positives = 1253/1253 (100%)

Query: 1    MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
            MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 1    MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60

Query: 61   TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
            TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 61   TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120

Query: 121  YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
            YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 121  YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180

Query: 181  NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
            NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 181  NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240

Query: 241  YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
            YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 241  YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300

Query: 301  YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
            YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 301  YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360

Query: 361  GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
            GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 361  GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420

Query: 421  GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
            GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 421  GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480

Query: 481  KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
            KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 481  KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540

Query: 541  DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
            DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 541  DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600

Query: 601  LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
            LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 601  LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660

Query: 661  IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
            IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK
Sbjct: 661  IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720

Query: 721  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
            HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ
Sbjct: 721  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780

Query: 781  REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
            REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP
Sbjct: 781  REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840

Query: 841  CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
            CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP
Sbjct: 841  CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900

Query: 901  RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960
            RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN
Sbjct: 901  RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960

Query: 961  HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020
            HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS
Sbjct: 961  HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020

Query: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080
            PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR
Sbjct: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080

Query: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140
            LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS
Sbjct: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140

Query: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200
            ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD
Sbjct: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200

Query: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253
            HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Sbjct: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253


>gi|197313730 pleckstrin homology-like domain, family B, member 2
            isoform a [Homo sapiens]
          Length = 1253

 Score = 2467 bits (6395), Expect = 0.0
 Identities = 1253/1253 (100%), Positives = 1253/1253 (100%)

Query: 1    MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
            MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 1    MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60

Query: 61   TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
            TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 61   TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120

Query: 121  YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
            YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 121  YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180

Query: 181  NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
            NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 181  NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240

Query: 241  YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
            YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 241  YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300

Query: 301  YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
            YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 301  YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360

Query: 361  GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
            GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 361  GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420

Query: 421  GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
            GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 421  GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480

Query: 481  KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
            KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 481  KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540

Query: 541  DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
            DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 541  DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600

Query: 601  LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
            LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 601  LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660

Query: 661  IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
            IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK
Sbjct: 661  IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720

Query: 721  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
            HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ
Sbjct: 721  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780

Query: 781  REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
            REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP
Sbjct: 781  REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840

Query: 841  CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
            CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP
Sbjct: 841  CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900

Query: 901  RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960
            RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN
Sbjct: 901  RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960

Query: 961  HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020
            HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS
Sbjct: 961  HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020

Query: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080
            PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR
Sbjct: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080

Query: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140
            LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS
Sbjct: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140

Query: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200
            ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD
Sbjct: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200

Query: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253
            HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Sbjct: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253


>gi|197313728 pleckstrin homology-like domain, family B, member 2
            isoform b [Homo sapiens]
          Length = 1237

 Score = 2364 bits (6126), Expect = 0.0
 Identities = 1210/1253 (96%), Positives = 1210/1253 (96%), Gaps = 43/1253 (3%)

Query: 1    MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
            MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 28   MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 87

Query: 61   TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
            TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 88   TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 147

Query: 121  YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
            YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 148  YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 207

Query: 181  NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
            NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 208  NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 267

Query: 241  YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
            YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 268  YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 327

Query: 301  YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
            YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 328  YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 387

Query: 361  GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
            GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 388  GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 447

Query: 421  GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
            GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 448  GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 507

Query: 481  KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
            KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 508  KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 567

Query: 541  DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
            DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 568  DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 627

Query: 601  LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
            LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 628  LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 687

Query: 661  IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
            IVGEKTK                                           DADLLDVESK
Sbjct: 688  IVGEKTK-------------------------------------------DADLLDVESK 704

Query: 721  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
            HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ
Sbjct: 705  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764

Query: 781  REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
            REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP
Sbjct: 765  REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 824

Query: 841  CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
            CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP
Sbjct: 825  CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 884

Query: 901  RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960
            RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN
Sbjct: 885  RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 944

Query: 961  HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020
            HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS
Sbjct: 945  HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1004

Query: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080
            PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR
Sbjct: 1005 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1064

Query: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140
            LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS
Sbjct: 1065 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1124

Query: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200
            ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD
Sbjct: 1125 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1184

Query: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253
            HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Sbjct: 1185 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1237


>gi|21955172 pleckstrin homology-like domain, family B, member 2
            isoform c [Homo sapiens]
          Length = 1210

 Score = 2364 bits (6126), Expect = 0.0
 Identities = 1210/1253 (96%), Positives = 1210/1253 (96%), Gaps = 43/1253 (3%)

Query: 1    MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
            MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 1    MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60

Query: 61   TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
            TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 61   TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120

Query: 121  YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
            YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 121  YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180

Query: 181  NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
            NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 181  NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240

Query: 241  YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
            YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 241  YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300

Query: 301  YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
            YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 301  YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360

Query: 361  GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
            GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 361  GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420

Query: 421  GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
            GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 421  GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480

Query: 481  KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
            KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 481  KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540

Query: 541  DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
            DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 541  DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600

Query: 601  LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
            LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 601  LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660

Query: 661  IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
            IVGEKTK                                           DADLLDVESK
Sbjct: 661  IVGEKTK-------------------------------------------DADLLDVESK 677

Query: 721  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
            HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ
Sbjct: 678  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 737

Query: 781  REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
            REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP
Sbjct: 738  REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 797

Query: 841  CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
            CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP
Sbjct: 798  CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 857

Query: 901  RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960
            RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN
Sbjct: 858  RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 917

Query: 961  HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020
            HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS
Sbjct: 918  HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 977

Query: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080
            PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR
Sbjct: 978  PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1037

Query: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140
            LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS
Sbjct: 1038 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1097

Query: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200
            ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD
Sbjct: 1098 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1157

Query: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253
            HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Sbjct: 1158 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1210


>gi|221219026 pleckstrin homology-like domain, family B, member 1
            isoform b [Homo sapiens]
          Length = 1319

 Score =  625 bits (1612), Expect = e-179
 Identities = 386/881 (43%), Positives = 513/881 (58%), Gaps = 167/881 (18%)

Query: 407  PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 465
            P  RERK+SI+ IS   DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D 
Sbjct: 570  PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629

Query: 466  RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
                G    ++  I +    L L+                         P   LA     
Sbjct: 630  ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663

Query: 526  SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
            S       T R   + E  SD        SST    S++  +        E     +   
Sbjct: 664  SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711

Query: 586  ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
            E+ A+EE R  +L ++E+LK ++K++  Q+ ES RE +ME ALL G              
Sbjct: 712  EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQG-------------- 757

Query: 646  ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQ 705
                              E+  E+  L  E++ +++LQE     +T +           Q
Sbjct: 758  ------------------EREAERALLQKEQKAVDQLQEKLVALETGI-----------Q 788

Query: 706  QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765
            ++  ++A+ L+ E+K FEDLEFQQLE ESR++EE+E   Q LLR  AE  R+I  RKE++
Sbjct: 789  KERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERL 848

Query: 766  SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPN 825
            + L  QA  I  QA +E +   ++KN  + +LQ+EKE L  LE++Y SL+GG+ FP   +
Sbjct: 849  AILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTS 908

Query: 826  TLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEER 885
            TLKE Y S  +     G +T+  P T+                                 
Sbjct: 909  TLKEVYRSKMD-----GEATSPLPRTR--------------------------------- 930

Query: 886  KKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAA 945
                      S  LP    +SS S   S AT+GRS +PK+ L     N  GS LP +LAA
Sbjct: 931  ----------SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLT--QNGTGS-LPRNLAA 977

Query: 946  MAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFH-----------YP 992
              +D E++R L  +    Q + E  R+ +E   + A+E+    ++ H           +P
Sbjct: 978  TLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFP 1037

Query: 993  D---HSYK-------------DQAFDTLSLDSSDSMETSIS-----ACSPDNISSASTSN 1031
                HS               + A+DTLSL+SSDSMETSIS     ACSPDN+SSAS  +
Sbjct: 1038 PLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLD 1097

Query: 1032 IARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKL 1091
            + +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RRRE +E+RLQ E+++RQ+L
Sbjct: 1098 MGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQL 1157

Query: 1092 IEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLI 1151
            +EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +DTC HV ++ K CRG+L+
Sbjct: 1158 VEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLV 1217

Query: 1152 KMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNP 1211
            KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQAIEEVYYDHL++A KSPNP
Sbjct: 1218 KMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNP 1277

Query: 1212 LLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFL 1252
             LTF VKTHDR+YYMVAPS EAMRIWMDVIVTGAEGYT F+
Sbjct: 1278 ALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFM 1318


>gi|221219024 pleckstrin homology-like domain, family B, member 1
            isoform a [Homo sapiens]
          Length = 1377

 Score =  620 bits (1600), Expect = e-177
 Identities = 388/893 (43%), Positives = 524/893 (58%), Gaps = 133/893 (14%)

Query: 407  PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 465
            P  RERK+SI+ IS   DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D 
Sbjct: 570  PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629

Query: 466  RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
                G    ++  I +    L L+                         P   LA     
Sbjct: 630  ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663

Query: 526  SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
            S       T R   + E  SD        SST    S++  +        E     +   
Sbjct: 664  SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711

Query: 586  ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
            E+ A+EE R  +L ++E+LK ++K++  Q+ ES RE +ME ALL G              
Sbjct: 712  EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQG-------------- 757

Query: 646  ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQ 705
                              E+  E+  L  E++ +++LQE     +T +           Q
Sbjct: 758  ------------------EREAERALLQKEQKAVDQLQEKLVALETGI-----------Q 788

Query: 706  QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765
            ++  ++A+ L+ E+K FEDLEFQQLE ESR++EE+E   Q LLR  AE  R+I  RKE++
Sbjct: 789  KERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERL 848

Query: 766  SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPN 825
            + L  QA  I  QA +E +   ++KN  + +LQ+EKE L  LE++Y SL+GG+ FP   +
Sbjct: 849  AILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTS 908

Query: 826  TLKE-GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEE 884
            TLKE   + +  ++        ++     PA A   ++ P     AS+    + +RS  +
Sbjct: 909  TLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASR--QLQVYRSKMD 966

Query: 885  RKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLA 944
             +         S  LP    +SS S   S AT+GRS +PK+ L     N  GS LP +LA
Sbjct: 967  GEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLT--QNGTGS-LPRNLA 1023

Query: 945  AMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFH-----------Y 991
            A  +D E++R L  +    Q + E  R+ +E   + A+E+    ++ H           +
Sbjct: 1024 ATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGF 1083

Query: 992  PD---HSYK-------------DQAFDTLSLDSSDSMETSIS-----ACSPDNISSASTS 1030
            P    HS               + A+DTLSL+SSDSMETSIS     ACSPDN+SSAS  
Sbjct: 1084 PPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGL 1143

Query: 1031 NIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1090
            ++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RRRE +E+RLQ E+++RQ+
Sbjct: 1144 DMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQ 1203

Query: 1091 LIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFL 1150
            L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +DTC HV ++ K CRG+L
Sbjct: 1204 LVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYL 1263

Query: 1151 IKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANK--- 1207
            +KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQAIEEVYYDHL++A K   
Sbjct: 1264 VKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRF 1323

Query: 1208 --------SPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFL 1252
                    SPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIVTGAEGYT F+
Sbjct: 1324 FRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFM 1376



 Score = 34.3 bits (77), Expect = 0.77
 Identities = 91/427 (21%), Positives = 157/427 (36%), Gaps = 59/427 (13%)

Query: 392  EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLERQR 449
            E+ +E  R+ +G  Q  LR +   + SI+ R + +     Q  +   +  QE ERL R +
Sbjct: 816  ESRVEEERELAG--QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDK 873

Query: 450  LETILSLCAEYTKPD------SRLSTGTTVEDVQKINKELEKLQLS--DEESVFEEALMS 501
              ++  L  E  K          L+ G          KE+EKL L   D E  ++E +  
Sbjct: 874  NASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAG 933

Query: 502  PDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDL--TRTPPPPSSTFP 559
              T        S P    A      ++S      RS  + E  S L  TR+ P PSS+  
Sbjct: 934  LGTGPAAASPHSSPPPLPA------KASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGS 987

Query: 560  KASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLE-----ELKQKIKDINDQ 614
             +SS    ++ L ++P   S         ++       L ++E      L+QK + + ++
Sbjct: 988  SSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEE 1047

Query: 615  MDESFRELDMECALLDGEQKSETTEL---------------MKEKEILDHLNRKIAELEK 659
                  EL  + A    E + +   L               +    IL HL    A  E+
Sbjct: 1048 QRRRLAELKQKAA---AEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLP---AGRER 1101

Query: 660  NIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP----------ESMREQLQQQLK 709
               GE   + + L++  + +E             DN            E M + L++   
Sbjct: 1102 GEEGEHAYDTLSLESS-DSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHA 1160

Query: 710  RDADLLDVESKHFEDLEFQQLEHESRLDEEKE-NLTQQLLREVAEYQRNIVSRKEKISAL 768
                L++   +  E L  Q LE E R  E+ E  L  +  R     ++ +  R+++ S  
Sbjct: 1161 EKNRLMESREREME-LRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQA 1219

Query: 769  KKQANHI 775
            +    ++
Sbjct: 1220 RPLTRYL 1226


>gi|38424073 pleckstrin homology-like domain, family B, member 1
            isoform a [Homo sapiens]
          Length = 1377

 Score =  620 bits (1600), Expect = e-177
 Identities = 388/893 (43%), Positives = 524/893 (58%), Gaps = 133/893 (14%)

Query: 407  PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 465
            P  RERK+SI+ IS   DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D 
Sbjct: 570  PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629

Query: 466  RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
                G    ++  I +    L L+                         P   LA     
Sbjct: 630  ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663

Query: 526  SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
            S       T R   + E  SD        SST    S++  +        E     +   
Sbjct: 664  SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711

Query: 586  ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
            E+ A+EE R  +L ++E+LK ++K++  Q+ ES RE +ME ALL G              
Sbjct: 712  EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQG-------------- 757

Query: 646  ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQ 705
                              E+  E+  L  E++ +++LQE     +T +           Q
Sbjct: 758  ------------------EREAERALLQKEQKAVDQLQEKLVALETGI-----------Q 788

Query: 706  QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765
            ++  ++A+ L+ E+K FEDLEFQQLE ESR++EE+E   Q LLR  AE  R+I  RKE++
Sbjct: 789  KERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERL 848

Query: 766  SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPN 825
            + L  QA  I  QA +E +   ++KN  + +LQ+EKE L  LE++Y SL+GG+ FP   +
Sbjct: 849  AILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTS 908

Query: 826  TLKE-GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEE 884
            TLKE   + +  ++        ++     PA A   ++ P     AS+    + +RS  +
Sbjct: 909  TLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASR--QLQVYRSKMD 966

Query: 885  RKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLA 944
             +         S  LP    +SS S   S AT+GRS +PK+ L     N  GS LP +LA
Sbjct: 967  GEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLT--QNGTGS-LPRNLA 1023

Query: 945  AMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFH-----------Y 991
            A  +D E++R L  +    Q + E  R+ +E   + A+E+    ++ H           +
Sbjct: 1024 ATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGF 1083

Query: 992  PD---HSYK-------------DQAFDTLSLDSSDSMETSIS-----ACSPDNISSASTS 1030
            P    HS               + A+DTLSL+SSDSMETSIS     ACSPDN+SSAS  
Sbjct: 1084 PPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGL 1143

Query: 1031 NIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1090
            ++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RRRE +E+RLQ E+++RQ+
Sbjct: 1144 DMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQ 1203

Query: 1091 LIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFL 1150
            L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +DTC HV ++ K CRG+L
Sbjct: 1204 LVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYL 1263

Query: 1151 IKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANK--- 1207
            +KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQAIEEVYYDHL++A K   
Sbjct: 1264 VKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRF 1323

Query: 1208 --------SPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFL 1252
                    SPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIVTGAEGYT F+
Sbjct: 1324 FRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFM 1376



 Score = 34.3 bits (77), Expect = 0.77
 Identities = 91/427 (21%), Positives = 157/427 (36%), Gaps = 59/427 (13%)

Query: 392  EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLERQR 449
            E+ +E  R+ +G  Q  LR +   + SI+ R + +     Q  +   +  QE ERL R +
Sbjct: 816  ESRVEEERELAG--QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDK 873

Query: 450  LETILSLCAEYTKPD------SRLSTGTTVEDVQKINKELEKLQLS--DEESVFEEALMS 501
              ++  L  E  K          L+ G          KE+EKL L   D E  ++E +  
Sbjct: 874  NASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAG 933

Query: 502  PDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDL--TRTPPPPSSTFP 559
              T        S P    A      ++S      RS  + E  S L  TR+ P PSS+  
Sbjct: 934  LGTGPAAASPHSSPPPLPA------KASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGS 987

Query: 560  KASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLE-----ELKQKIKDINDQ 614
             +SS    ++ L ++P   S         ++       L ++E      L+QK + + ++
Sbjct: 988  SSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEE 1047

Query: 615  MDESFRELDMECALLDGEQKSETTEL---------------MKEKEILDHLNRKIAELEK 659
                  EL  + A    E + +   L               +    IL HL    A  E+
Sbjct: 1048 QRRRLAELKQKAA---AEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLP---AGRER 1101

Query: 660  NIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP----------ESMREQLQQQLK 709
               GE   + + L++  + +E             DN            E M + L++   
Sbjct: 1102 GEEGEHAYDTLSLESS-DSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHA 1160

Query: 710  RDADLLDVESKHFEDLEFQQLEHESRLDEEKE-NLTQQLLREVAEYQRNIVSRKEKISAL 768
                L++   +  E L  Q LE E R  E+ E  L  +  R     ++ +  R+++ S  
Sbjct: 1161 EKNRLMESREREME-LRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQA 1219

Query: 769  KKQANHI 775
            +    ++
Sbjct: 1220 RPLTRYL 1226


>gi|157266264 pleckstrin homology-like domain, family B, member 3
            [Homo sapiens]
          Length = 640

 Score =  201 bits (510), Expect = 5e-51
 Identities = 111/212 (52%), Positives = 130/212 (61%), Gaps = 31/212 (14%)

Query: 1035 IEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEK 1094
            I  MERLL+QA AE+ RLL++R    E  +R  E                          
Sbjct: 455  IAHMERLLQQAMAERERLLKAR----EGTRRGTEGSSG---------------------- 488

Query: 1095 EVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMG 1154
                     A   P T   P      DLR H+E  GHN + C HV ++   CRG L+KMG
Sbjct: 489  -----PAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMG 543

Query: 1155 GKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLT 1214
            G+IKTW+KRWF FDR  R  +YYADK ETKLKGVIYFQAIEEVYYDHL+ A KSPNP LT
Sbjct: 544  GRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLT 603

Query: 1215 FSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAE 1246
            F VKT++R++YMVAPSPEAMRIWMDVIVT A+
Sbjct: 604  FCVKTYERLFYMVAPSPEAMRIWMDVIVTAAD 635



 Score =  114 bits (284), Expect = 8e-25
 Identities = 110/418 (26%), Positives = 189/418 (45%), Gaps = 66/418 (15%)

Query: 550 TPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIK 609
           TPP   +  P AS+ S       +   G +   + Q+L A+  TR+ ++      +Q++K
Sbjct: 75  TPPIAMAATPPASTSSR------EGVRGAARRLQGQQLEAL--TRVALM------EQRVK 120

Query: 610 DINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEK 669
           ++  Q  E   E+++E ALL GE   E     +E+E L  L  + A  E+    ++ +E+
Sbjct: 121 ELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQ 180

Query: 670 VKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQ 729
            +L  ER++LE L++   + + QLD+ PE  RE+L Q ++   + LDV  + +EDLEFQQ
Sbjct: 181 RRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQ 240

Query: 730 LEHESRLDEEKEN---------LTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
           LE ESR +EE  +           Q+L   +A+++R  +  + +I  L++Q   + +Q  
Sbjct: 241 LERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGAL--QHRIRVLEEQLKSLGEQMA 298

Query: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
            E     ++K   +  L +E+  L  L    + L G  G                + +EP
Sbjct: 299 AESRGLSRKKEEALQALSQERSRLLEL----NCLQGTPG---------------GDFSEP 339

Query: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
               T L  + +   D   +  + A A  A+ P S   F        Q   GL  + +LP
Sbjct: 340 NPALTKLLFTQK--TDRQLLVLQDAVAHSAATPTSSCLFS--VHSSLQGSIGLQRTGSLP 395

Query: 901 RKK--------TTSSISPHFSSATMGRSITP----KAHLPL------GQSNSCGSVLP 940
           RK+        +   +S H + +    ++ P        PL      G+ NSCG++ P
Sbjct: 396 RKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHP 453


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 118/594 (19%), Positives = 248/594 (41%), Gaps = 93/594 (15%)

Query: 573  KTPEGISEEQRSQELA-----------AMEETRIVILNNLEELKQKIKDINDQMDESFRE 621
            K  E  SE +R+Q L            A++E   ++   L E +++++ +  Q+ E  ++
Sbjct: 1391 KNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ 1450

Query: 622  LDMECALLD-------------GEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKE 668
             +M+ A L+               Q+ +  EL K + +L+HL   + E E+ +  ++ + 
Sbjct: 1451 REMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI 1510

Query: 669  KVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADL----LDVESKHFED 724
            + +L+ +RE    + E    +  + D   ES R Q+Q   K+   L    L++E  H + 
Sbjct: 1511 R-ELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK- 1568

Query: 725  LEFQQL---EHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQR 781
            +E QQ    E E + + ++  LT   L ++ E  + + ++  +I  L+  +  + ++ Q 
Sbjct: 1569 MECQQKLIKELEGQRETQRVALTHLTL-DLEERSQELQAQSSQIHDLESHSTVLARELQ- 1626

Query: 782  EQDHFVKEKNNLIMMLQREKENLC-NLEKKYSSL------------SGGKGFPVNPNTLK 828
            E+D  VK +   I  LQR+KE+L  +LE++   L               +   +    L+
Sbjct: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686

Query: 829  EGYISVNEINEPCGNSTNL----SPSTQFPADADAVATEPATAVLASQPQ----SKEHFR 880
            +  +S+ E          L    +   + P+ A   + E    +L  + +     +EH  
Sbjct: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746

Query: 881  SLEERKKQHKEGLYLSDTLPRKKTTSSI---SPHFSSATMGRSITPKAHLPLGQSNSCGS 937
             L+E K Q ++ L     L RK   +S+           + + +         +  S  S
Sbjct: 1747 ELQELKDQLEQQL---QGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQS 1803

Query: 938  VLPPSLAAMAKDSESRRMLRGYNHQQMSEGH----RQKSEFYNRTASESNVYLNSFHYPD 993
             L  +  A+A+  +    L+    QQ ++G     ++K++       ++++ L   H   
Sbjct: 1804 QLDEAQRALAQRDQELEALQ--QEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGEL 1861

Query: 994  HSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLL 1053
              +K+QA     L+   ++E                    R++ +E +L    AE     
Sbjct: 1862 QDHKEQA---RRLEEELAVEG------------------RRVQALEEVLGDLRAES---- 1896

Query: 1054 ESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQAR 1107
              +E+ + A ++   E+ +  E+  + LQ+   Q Q ++++  +  E  RA+++
Sbjct: 1897 REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQ 1950



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 131/596 (21%), Positives = 246/596 (41%), Gaps = 103/596 (17%)

Query: 581  EQRSQELAA-------MEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ 633
            E+RSQEL A       +E    V+   L+E  Q++K   +Q++E  R+   E    D E+
Sbjct: 1598 EERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQ--KEHLTQDLER 1655

Query: 634  KSETTELMKEK-EIL-DHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKT 691
            + +   L KE+ ++L D   R+   LE+++      E++KL       ER +EL ++++ 
Sbjct: 1656 RDQELMLQKERIQVLEDQRTRQTKILEEDL------EQIKLSLR----ERGRELTTQRQL 1705

Query: 692  QLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL--- 748
              +   E       Q+   +   L +  K  +++E QQ EH   L E K+ L QQL    
Sbjct: 1706 MQERAEEGKGPSKAQRGSLEHMKLILRDKE-KEVECQQ-EHIHELQELKDQLEQQLQGLH 1763

Query: 749  REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 808
            R+V E    +  R+++I  L++Q     +Q + ++     + +     L +  + L  L+
Sbjct: 1764 RKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQ 1823

Query: 809  KKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAV 868
            ++     G +        +KE                         ADA   A E A   
Sbjct: 1824 QEQQQAQGQE------ERVKE------------------------KADALQGALEQAHMT 1853

Query: 869  LASQ----PQSKEHFRSLEE------RKKQHKE---GLYLSDTLPRKKTTSSISPHFSSA 915
            L  +       KE  R LEE      R+ Q  E   G   +++  ++K   ++    +  
Sbjct: 1854 LKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQ 1913

Query: 916  TMGRSITPKAHLPLG-QSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEF 974
                 +  +A      Q+ +        L A+  +S+S R      HQ+  E  R ++E 
Sbjct: 1914 AQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSR------HQE--EAARARAEA 1965

Query: 975  YNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDS-METSISACSPDNISSASTSNIA 1033
                  +++  L      +    +QA  + SL++S + ++ S+ AC   +        I 
Sbjct: 1966 LQEALGKAHAALQG---KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQ 2022

Query: 1034 ---------RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEE 1084
                     R +E  + L+QA A++   L    R  + +++ LE+   +R + E  +QE+
Sbjct: 2023 EGEIQDQDLRYQEDVQQLQQALAQRDEEL----RHQQEREQLLEKSLAQR-VQENMIQEK 2077

Query: 1085 TSQRQKLIEKEVK-----IRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDT 1135
             +  Q+  E+E++     +RE Q   A+     L +R  +   R+++E   H+  T
Sbjct: 2078 QNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELR--ETQQRNNLEALPHSHKT 2131



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 126/582 (21%), Positives = 237/582 (40%), Gaps = 97/582 (16%)

Query: 582  QRSQELAAMEETRIVILNNLEELKQKIKDINDQM---DESFRELDMECALLDGEQKSETT 638
            Q   +LAA++E    +L +  +L+++++D+  Q+   D+S R ++ E      E+  ET 
Sbjct: 986  QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQ----EKLRETQ 1041

Query: 639  ELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPE 698
            E  +              ++K +  EK    + L  + ++L  LQE  S ++ +L    +
Sbjct: 1042 EYNR--------------IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQ 1087

Query: 699  SMREQL--QQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKE--NLTQQLLR----- 749
             M+E    Q++L    +LL  E K   + E   L  E++L EE E  ++T+Q LR     
Sbjct: 1088 DMQEAQGEQKELSAQMELLRQEVK---EKEADFLAQEAQLLEELEASHITEQQLRASLWA 1144

Query: 750  ---EVAEYQ---RNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKEN 803
               + A+ Q   R+  S+ E ++A ++  N    QAQ           +L   LQ+   +
Sbjct: 1145 QEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLA---------SLYSALQQALGS 1195

Query: 804  LCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPS----TQFPADADA 859
            +C    + S   GG   P           SV  +      + +L       T   A+A A
Sbjct: 1196 VCESRPELS--GGGDSAP-----------SVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242

Query: 860  VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGR 919
             A       L    Q+++  R   ++ ++      L+DT   K        H     + R
Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEER-----LTDTEAEKSQV-----HTELQDLQR 1292

Query: 920  SITPKAHLPL---GQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN 976
             ++          G+ NS  S L      MA  S   R+ R    +  ++G R+  +   
Sbjct: 1293 QLSQNQEEKSKWEGKQNSLESELMELHETMA--SLQSRLRRAELQRMEAQGERELLQ--- 1347

Query: 977  RTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIE 1036
              A++ N+     H      + +A  + +    + + T+ SA    N    S    A+  
Sbjct: 1348 --AAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQAL 1405

Query: 1037 EMERLLKQAHAEK--------TRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQR 1088
            + +  LK A  +         T+ L  RE E+E  +  ++E +++RE ++K   E  S  
Sbjct: 1406 QEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQRE-MQKAALELLSLD 1464

Query: 1089 QKLIEKEVKIRERQ---RAQARPLTRYLPVRKEDFDLRSHVE 1127
             K   +EV +++ Q     + R +  +LP+  ++ + +  V+
Sbjct: 1465 LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQ 1506



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 52/226 (23%), Positives = 109/226 (48%), Gaps = 24/226 (10%)

Query: 585 QELAAMEETRIVILNNLEELKQKIKDINDQMD--ESFRELDMECALLDGEQKSETTELMK 642
           QE  A+   +  +   L+ +++  +D+ +Q+    S +EL +E +L + +Q++   E+ K
Sbjct: 729 QEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKEL-LESSLFEAQQQNSVIEVTK 787

Query: 643 EKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMRE 702
            +  L+   + + + ++ I GE    K++LD ER + E+ ++  + Q  Q +   ++  E
Sbjct: 788 GQ--LEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE 845

Query: 703 QLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRK 762
           Q +   +++ + L       E  E ++  H+  L +  E+L     RE  E +  +  ++
Sbjct: 846 QQKAAHEKEVNQLR------EKWEKERSWHQQELAKALESLE----REKMELEMRLKEQQ 895

Query: 763 EKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 808
            ++ A+         QAQRE++    E     M L+ EKE +  LE
Sbjct: 896 TEMEAI---------QAQREEERTQAESALCQMQLETEKERVSLLE 932



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 108/505 (21%), Positives = 210/505 (41%), Gaps = 52/505 (10%)

Query: 427 DYHRRQREERLREQEMERLERQRL-ETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEK 485
           D  + Q+EE+  E  +   ER+RL E ++ L A+ ++  S L T     +   +  EL +
Sbjct: 501 DSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLR 560

Query: 486 LQLSDEESVFEEALMSPDTRYRCHRKDSLPDADL-ASCGSLSQSSASFFTPRSTRNDELL 544
            + ++  +    A  S               ADL A+   LS  + +    +   N +LL
Sbjct: 561 QEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLL 620

Query: 545 SDLTRTPPPPSSTFPKASSESSYLSI----LPKTPEGISEEQRSQE--LAAMEETRIVIL 598
             L        S    A    + L +      K  E + E+    E  L   EE    + 
Sbjct: 621 -QLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQ 679

Query: 599 NNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELE 658
            +L +++++ ++I  ++ ES  +   E A    EQ  +  E  +++E+   L R + E E
Sbjct: 680 ADLRDIQEEKEEIQKKLSESRHQ--QEAATTQLEQLHQ--EAKRQEEV---LARAVQEKE 732

Query: 659 KNIVGEKTKEKVKLDA-EREK---LERLQELYSEQK---------TQLDNCPESMREQLQ 705
             +V EK   +V+L A ER++    E+LQ L S ++          Q ++  E  + QL+
Sbjct: 733 A-LVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLE 791

Query: 706 QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765
            Q++      +V       L+ +     S+ ++E++   +QL +   E +  +  +K   
Sbjct: 792 VQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQK--- 848

Query: 766 SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENL-CNLEKKYSSLSGGKGFPVNP 824
           +A +K+ N + ++ ++E+    +E    +  L+REK  L   L+++ + +   +      
Sbjct: 849 AAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEE 908

Query: 825 NTLKEGYISVNEINEPCGNSTNLSPSTQFPAD-ADA---------------VATEPATAV 868
            T  E  +   ++       + L    Q   + ADA               +  +  T +
Sbjct: 909 RTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI 968

Query: 869 LASQPQSKEHFRSLEERKKQHKEGL 893
           L  Q Q +E  R L+E  +QH++ L
Sbjct: 969 L--QTQLQEAQRELKEAARQHRDDL 991



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 142/736 (19%), Positives = 277/736 (37%), Gaps = 97/736 (13%)

Query: 417  SSISGRDDLMDYHRRQREERLRE-QEMERLERQRLETILSLCAEYTKPDSRLSTGTTVED 475
            S +  +DD      ++ +E+LRE QE  R++++      SL     + + RL      + 
Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADS 1076

Query: 476  VQKINKELEKLQLSDEESVFEEALMSPDTRY-RCHRKDSLPDADLASCGSLSQSSASFFT 534
            +++  +EL  L+   +E+  E+  +S      R   K+   D        L +  AS  T
Sbjct: 1077 IRQ--QELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHIT 1134

Query: 535  PRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETR 594
             +  R     + L       +    +  S  S L  L    +  ++ Q   +LA++    
Sbjct: 1135 EQQLR-----ASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSAL 1189

Query: 595  IVILNNLEELKQKIKDINDQMDESF---------RELDMECALLDGEQKSETT------- 638
               L ++ E + ++    D     +         R L     LL                
Sbjct: 1190 QQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249

Query: 639  -ELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP 697
             +L K ++  D L  ++ +LE+ +   +  EK ++  E + L+R      E+K++ +   
Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEA-EKSQVHTELQDLQRQLSQNQEEKSKWEGKQ 1308

Query: 698  ESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESR---LDEEKENLTQQLLREVAEY 754
             S+  +L +  +  A L           E Q++E +     L   KENLT Q    V   
Sbjct: 1309 NSLESELMELHETMASL----QSRLRRAELQRMEAQGERELLQAAKENLTAQ----VEHL 1360

Query: 755  QRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 814
            Q  +V  + + SA       I+++  R     +K KN  +   + E+E    L+++   L
Sbjct: 1361 QAAVVEARAQASAAG-----ILEEDLRTARSALKLKNEEV---ESERERAQALQEQ-GEL 1411

Query: 815  SGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQ 874
               +G       L+E                NL+  TQ  A+      E     L  Q Q
Sbjct: 1412 KVAQG-----KALQE----------------NLALLTQTLAER-----EEEVETLRGQIQ 1445

Query: 875  SKEHFRSLEERKKQHKEGLYLS--DTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQS 932
                   LE++++  K  L L   D   R +               RS+     + + + 
Sbjct: 1446 E------LEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQER 1499

Query: 933  NSCGSVLPPSLAAMAKDSESRR------MLRGYNHQQMSEGHRQKSEFYNRTASESNVYL 986
                +V    +  + KD E++R      +L      QM E   Q+ +  +       +  
Sbjct: 1500 EQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIES--QRGQVQDLKKQLVTLEC 1557

Query: 987  NSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAH 1046
             +    ++ +K +    L  +     ET   A +   +     S   + +  +    ++H
Sbjct: 1558 LALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESH 1617

Query: 1047 AEK-TRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQ 1105
            +    R L+ R++E+++++  +EE +R++E L + L E   Q   L ++ +++ E QR  
Sbjct: 1618 STVLARELQERDQEVKSQREQIEELQRQKEHLTQDL-ERRDQELMLQKERIQVLEDQR-- 1674

Query: 1106 ARPLTRYLPVRKEDFD 1121
                TR   + +ED +
Sbjct: 1675 ----TRQTKILEEDLE 1686



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 52/242 (21%), Positives = 110/242 (45%), Gaps = 16/242 (6%)

Query: 580  EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTE 639
            + +R +E  A+E  R+     LEE+   ++  + + +++   L  +CA    E + ET  
Sbjct: 1867 QARRLEEELAVEGRRV---QALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRA 1923

Query: 640  L----MKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDN 695
            L    ++ + +L   ++++  L       + +E    +A R + E LQE   +    L  
Sbjct: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQE----EAARARAEALQEALGKAHAALQG 1979

Query: 696  CPESMREQLQQQLKRDADLLDVE-SKHFEDLEFQQLEHESRLDE-EKENLTQQLLREVAE 753
              + + EQ +     +A    ++ S        +QLE   R+ E E ++   +   +V +
Sbjct: 1980 KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ 2039

Query: 754  YQRNIVSRKEKISALKKQANHIVQQ-AQREQDHFVKEKNNLIMMLQREKENLCNLEKKYS 812
             Q+ +  R E++   +++   + +  AQR Q++ ++EK NL    +RE+E +  L +   
Sbjct: 2040 LQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQ--EREEEEIRGLHQSVR 2097

Query: 813  SL 814
             L
Sbjct: 2098 EL 2099



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 138/765 (18%), Positives = 295/765 (38%), Gaps = 93/765 (12%)

Query: 392  EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 451
            EA L+   +A    Q  LR+ +     I  +   +   R Q+E    + E    E +R E
Sbjct: 665  EAQLQKAEEAGAELQADLRDIQEEKEEIQKK---LSESRHQQEAATTQLEQLHQEAKRQE 721

Query: 452  TILSLCAEYTKPDSRLSTGTTV--EDVQKINKEL-EKLQ-LSDEESVFEEALMSPDTRYR 507
             +L+   +  +   R      V  + V++  ++L E+LQ LS  + + E +L      + 
Sbjct: 722  EVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSL------FE 775

Query: 508  CHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSY 567
              +++S+ +    + G L     +    +     E+           S    +  + +  
Sbjct: 776  AQQQNSVIEV---TKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQ 832

Query: 568  LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQ----MDESFRELD 623
            L+   +  +   E+Q+    AA E+     +N L E  +K +  + Q      ES     
Sbjct: 833  LAQAEQEGKTALEQQK----AAHEKE----VNQLREKWEKERSWHQQELAKALESLEREK 884

Query: 624  MECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQ 683
            ME  +   EQ++E   +  ++E            E+    E    +++L+ E+E++  L+
Sbjct: 885  MELEMRLKEQQTEMEAIQAQRE------------EERTQAESALCQMQLETEKERVSLLE 932

Query: 684  ELYSEQKTQLDNCP--ESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKE 741
             L   QK   D     E +R+ ++ Q  ++ +   +     ++ + +  E   +  ++  
Sbjct: 933  TLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLA 992

Query: 742  NLTQQ---LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQ 798
             L ++   LL++  + Q+ +   K ++ A +  +  +V+Q  +E+    +E N +   L+
Sbjct: 993  ALQEESSSLLQDKMDLQKQVEDLKSQLVA-QDDSQRLVEQEVQEKLRETQEYNRIQKELE 1051

Query: 799  REKEN--LCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPAD 856
            REK +  L  +EK+   L   +   +    L        ++ E  G    LS   +    
Sbjct: 1052 REKASLTLSLMEKEQRLLVLQEADSIRQQELS---ALRQDMQEAQGEQKELSAQMELLRQ 1108

Query: 857  ADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDT------LPRKKTTSSISP 910
                  E     LA + Q  E   +    ++Q +  L+  +       L  + T S +  
Sbjct: 1109 E---VKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEA 1165

Query: 911  HFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQ 970
              +    G     +A L      S  S L  +L ++    ESR  L G      S    +
Sbjct: 1166 LAAEQQPGNQAQAQAQLA-----SLYSALQQALGSVC---ESRPELSGGGDSAPSVWGLE 1217

Query: 971  KSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTS 1030
              +   R+  +    L +                   S++++ +++     D   +  T 
Sbjct: 1218 PDQNGARSLFKRGPLLTAL------------------SAEAVASALHKLHQDLWKTQQTR 1259

Query: 1031 NIAR--IEEMERLLKQAHAEKTRL---LESREREMEAKKRALEEEKRRREILEKRLQEET 1085
            ++ R  ++++E  L    AEK+++   L+  +R++   +    + + ++  LE  L  E 
Sbjct: 1260 DVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELM-EL 1318

Query: 1086 SQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR-SHVETA 1129
             +    ++  ++  E QR +A+     L   KE+   +  H++ A
Sbjct: 1319 HETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAA 1363



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 123/711 (17%), Positives = 278/711 (39%), Gaps = 92/711 (12%)

Query: 427  DYHRRQREERLREQEMERLERQRLE-TILSLCAEYTKPDSRLSTGTTVEDVQKINKELEK 485
            ++H+ + +++L ++   + E QR+  T L+L  E    + +  + + + D++  +  L +
Sbjct: 1565 NHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQS-SQIHDLESHSTVLAR 1623

Query: 486  -LQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELL 544
             LQ  D+E   +   +    R + H    L   D      L +        + TR  ++L
Sbjct: 1624 ELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELM--LQKERIQVLEDQRTRQTKIL 1681

Query: 545  S-DLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEE 603
              DL +          + +++   +    +  +G S+ QR     ++E  ++++ +  +E
Sbjct: 1682 EEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRG----SLEHMKLILRDKEKE 1737

Query: 604  LK------QKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAEL 657
            ++       +++++ DQ+++  + L  +          ET+ L+ ++E      ++I  L
Sbjct: 1738 VECQQEHIHELQELKDQLEQQLQGLHRKVG--------ETSLLLSQRE------QEIVVL 1783

Query: 658  EKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV 717
            ++ +   + + ++K  + + +L+  Q   +++  +L+   +  ++Q Q Q +R  +  D 
Sbjct: 1784 QQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE-QQQAQGQEERVKEKADA 1842

Query: 718  ESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH--- 774
                 E       E    L + KE   ++L  E+A   R + + +E +  L+ ++     
Sbjct: 1843 LQGALEQAHMTLKERHGELQDHKEQ-ARRLEEELAVEGRRVQALEEVLGDLRAESREQEK 1901

Query: 775  ----IVQQ-AQREQDHFVKEKNNLIMMLQRE---KENLCNLE----KKYSSLSGGKGFPV 822
                + QQ A++ Q+H V+ +      LQ +   KE    LE    +  SS    +    
Sbjct: 1902 ALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARA 1961

Query: 823  NPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSK--EHFR 880
                L+E     +   +  G   +L    +     +A       ++ A Q  S+  E   
Sbjct: 1962 RAEALQEALGKAHAALQ--GKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL 2019

Query: 881  SLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLP 940
             ++E + Q ++  Y  D    ++  +              +  K+     Q N       
Sbjct: 2020 RIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQE--K 2077

Query: 941  PSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQA 1000
             +L    ++ E R + +     Q++   +++     R   + N    +     HS+K   
Sbjct: 2078 QNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRN----NLEALPHSHKTSP 2133

Query: 1001 FDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREM 1060
             +  SL   DS+E  +                    E+ERL       + R +E RE+  
Sbjct: 2134 MEEQSL-KLDSLEPRLQ------------------RELERLQAALRQTEAREIEWREKAQ 2174

Query: 1061 E-----AKKRA-----------LEEEKRRREILEKRLQEETSQRQKLIEKE 1095
            +     A+ +A           L+     R+  ++RLQ+E    ++ +EKE
Sbjct: 2175 DLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE 2225


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 125/596 (20%), Positives = 230/596 (38%), Gaps = 75/596 (12%)

Query: 581  EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMD----------------ESFR-ELD 623
            E+  ++L  +E  R V+   L E+++ +     Q D                E+ R EL+
Sbjct: 662  ERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELE 721

Query: 624  MECALLDGEQKSETTELMKEKEILDHL-------NRKIAELEKN---IVGEKTKEKVKLD 673
            +    L  E+ S    L K   + + L       NR +A+LE+    + G + + + +  
Sbjct: 722  LSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT 781

Query: 674  AEREKLERLQELYSEQKTQLDNCPESMR--EQLQQQLKRDADLLDVESKHFEDLEFQQLE 731
              RE+ ERL+EL  EQ+        S+R  EQ Q+ L++    L  E    ++   Q   
Sbjct: 782  VAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSR 841

Query: 732  HESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ--QAQREQDHFVKE 789
              S  ++E E   ++  R+V   +R   + +EK +  K+ A   VQ   A+RE     +E
Sbjct: 842  QLSGREQELEQARREAQRQVEALER---AAREKEALAKEHAGLAVQLVAAEREGRTLSEE 898

Query: 790  KNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSP 849
               L +  +  + +L  ++++ + L   +          EG   +       G    L  
Sbjct: 899  ATRLRLEKEALEGSLFEVQRQLAQLEARR-----EQLEAEGQALLLAKETLTGELAGLRQ 953

Query: 850  STQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSIS 909
              Q  A  +  + +            +E   SL E++  H+E L     L R+K  +   
Sbjct: 954  --QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL---QRLQREKEAAWRE 1008

Query: 910  PHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHR 969
                 A +   +  +    L +  +    L   +AA+ ++ +   +L             
Sbjct: 1009 LEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLL----------AES 1058

Query: 970  QKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNIS-SAS 1028
            +K +  +   SE            HS       T+SL+       + S    D  + +A 
Sbjct: 1059 EKQQALSLKESEKTALSEKLMGTRHSLA-----TISLEMERQKRDAQSRQEQDRSTVNAL 1113

Query: 1029 TSNIARIEEMERLLKQAHAEKTRLLESREREM-EAKKRALEEEKRRREILEKRLQEETSQ 1087
            TS +  +         AHA++ R L+ + R++ + +   L E +  R  L          
Sbjct: 1114 TSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGL 1173

Query: 1088 RQKLIEKEVKIRER------QRAQARPLTRYL--------PVRKEDFDLRSHVETA 1129
            R++L+E + K+RE       QR +A  L R L         +R+ + +LRS V+ A
Sbjct: 1174 RRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKA 1229



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 92/452 (20%), Positives = 181/452 (40%), Gaps = 44/452 (9%)

Query: 369  LAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDY 428
            LAG   ++ AT+   S       E   + L QA    Q +LRE++++       ++ +  
Sbjct: 948  LAGLRQQIIATQEKASLDK----ELMAQKLVQAEREAQASLREQRAA------HEEDLQR 997

Query: 429  HRRQREERLREQEMER------LERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKE 482
             +R++E   RE E ER      L+R++ E +  L AE  +    ++      D   +  E
Sbjct: 998  LQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE 1057

Query: 483  LEKLQL----SDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRST 538
             EK Q       E++   E LM   TR+         +       S  +   S     ++
Sbjct: 1058 SEKQQALSLKESEKTALSEKLMG--TRHSLATISLEMERQKRDAQSRQEQDRSTVNALTS 1115

Query: 539  RNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVIL 598
               +L +         +    +   ++  L     +    +EE R+Q L  +E+ R  + 
Sbjct: 1116 ELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQ-LRLLEDARDGLR 1174

Query: 599  NNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELE 658
              L E ++K+++      +  RE+  + A   GE +    E  KE+E L   N ++    
Sbjct: 1175 RELLEAQRKLRE-----SQEGREVQRQEA---GELRRSLGEGAKEREALRRSNEELRSAV 1226

Query: 659  KNIVGEKTKEKVKLDAEREKLERLQELYS-------EQKTQLDNCPESMREQLQ--QQLK 709
            K    E+   K+  + + +KL  L+E  +       E +T L     S  E  +  Q+L+
Sbjct: 1227 KKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELR 1286

Query: 710  RDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALK 769
            R   +LD E+      E  +L+    L E  E   ++  RE    ++ ++  +  +  ++
Sbjct: 1287 RQMKMLDSENTRL-GRELAELQGRLALGERAE---KESRRETLGLRQRLLKGEASLEVMR 1342

Query: 770  KQANHIVQQAQREQDHFVKEKNNLIMMLQREK 801
            ++     ++ Q ++  F   +  L+  L+  +
Sbjct: 1343 QELQVAQRKLQEQEGEFRTRERRLLGSLEEAR 1374



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 44/153 (28%), Positives = 74/153 (48%), Gaps = 7/153 (4%)

Query: 667 KEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDL- 725
           K ++++   R + E  Q+L    + QL +  ES R  L++QL+R  D  D   +  ED  
Sbjct: 530 KRQLQVQDMRGRYEASQDLLGTLRKQLSDS-ESERRALEEQLQRLRDKTDGAMQAHEDAQ 588

Query: 726 -EFQQLEHESRL-DEEKENLTQQLLREVAEYQ-RNIVSRKEKISALKKQANHIVQQAQRE 782
            E Q+L   + L   EK NL   L  +VA+ Q   +   +EK+ A +++      + + E
Sbjct: 589 REVQRLRSANELLSREKSNLAHSL--QVAQQQAEELRQEREKLQAAQEELRRQRDRLEEE 646

Query: 783 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS 815
           Q+  V++   +   L+R    L  LE K S L+
Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLA 679



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 155/774 (20%), Positives = 291/774 (37%), Gaps = 140/774 (18%)

Query: 373  SDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQ 432
            S+++  TR + +  S+E +    ++        Q    + +S++++++   +L D  R Q
Sbjct: 1075 SEKLMGTRHSLATISLEMERQKRDA--------QSRQEQDRSTVNALTS--ELRDL-RAQ 1123

Query: 433  REERL--REQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSD 490
            REE      QE+ RL+ Q               D      + + + +++  +L  L+  D
Sbjct: 1124 REEAAAAHAQEVRRLQEQAR-------------DLGKQRDSCLREAEELRTQLRLLE--D 1168

Query: 491  EESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRT 550
                    L+    + R  ++    +      G L +S       R          L R+
Sbjct: 1169 ARDGLRRELLEAQRKLRESQEGR--EVQRQEAGELRRSLGEGAKEREA--------LRRS 1218

Query: 551  PPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKD 610
                 S   KA SE   L +        + E + Q+LA +EE R  +     EL+  +++
Sbjct: 1219 NEELRSAVKKAESERISLKL--------ANEDKEQKLALLEEARTAVGKEAGELRTGLQE 1270

Query: 611  INDQMDESFRELDMECALLDGEQKSETTELMKEKEILD----HLNRKIAELEKNI-VGEK 665
            +     E+ REL                EL ++ ++LD     L R++AEL+  + +GE+
Sbjct: 1271 VERSRLEARRELQ---------------ELRRQMKMLDSENTRLGRELAELQGRLALGER 1315

Query: 666  TKEKVKLD--AEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFE 723
             +++ + +    R++L + +      + +L      ++EQ  +   R+  LL    +   
Sbjct: 1316 AEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLG-SLEEAR 1374

Query: 724  DLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQ 783
              E QQL+H   L+ + E        E AE    + + + +   L+ +   +  Q +  +
Sbjct: 1375 GTEKQQLDHARGLELKLE----AARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAE 1430

Query: 784  DHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGN 843
                 +   L   L+R       L    +     +  P +P        S   +N P  +
Sbjct: 1431 ----AQLGGLRSALRR------GLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSP--S 1478

Query: 844  STNLSPSTQFPADADAVATEPATAVL---ASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
            +   SP +Q P+     AT PA+  L   A +   +E  + L   +++  E         
Sbjct: 1479 TLECSPGSQPPSPGP--ATSPASPDLDPEAVRGALREFLQELRSAQRERDE--------- 1527

Query: 901  RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960
             +  TS+++   +     R             +S  S       A+A+  E+RR + G  
Sbjct: 1528 LRTQTSALNRQLAEMEAER-------------DSATSRARQLQKAVAESEEARRSVDGRL 1574

Query: 961  HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020
                +E   Q+ E   R+  E    L+                 +L+ S     S    S
Sbjct: 1575 SGVQAELALQE-ESVRRSERERRATLD--------------QVATLERSLQATESELRAS 1619

Query: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR------- 1073
             + IS    +N  ++E  +R LK    E     ESR  ++E ++R+LE E +R       
Sbjct: 1620 QEKISKMK-ANETKLEGDKRRLK----EVLDASESRTVKLELQRRSLEGELQRSRLGLSD 1674

Query: 1074 REILEKRLQEETSQRQKLI-EKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHV 1126
            RE   + LQ+     Q+ + + EVK    Q    R       V + +  LR  V
Sbjct: 1675 REAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKV 1728



 Score = 31.6 bits (70), Expect = 5.0
 Identities = 34/168 (20%), Positives = 75/168 (44%), Gaps = 32/168 (19%)

Query: 568  LSILPKTPEGISEEQRSQELAAM--EETRIVILNNLEEL-KQKIKDINDQMDESFRELDM 624
            L  L +    +  E+R  E +A+  E+ R+ +   L+++ ++K++   D +      L  
Sbjct: 1847 LGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV-----RLSA 1901

Query: 625  ECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQE 684
            E   LD        EL + +  +  L  ++  LE++     +  ++++DA++++LE  QE
Sbjct: 1902 EKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQS----HSPAQLEVDAQQQQLELQQE 1957

Query: 685  LYSEQKTQ--------------------LDNCPESMREQLQQQLKRDA 712
            +   +  Q                    L+    +++ QLQQ+L+R +
Sbjct: 1958 VERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSS 2005



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 20/49 (40%), Positives = 30/49 (61%), Gaps = 4/49 (8%)

Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEE 1084
            +E+ERL + A A+  R LE+RER    + R LEE+      L+ +LQ+E
Sbjct: 1956 QEVERL-RSAQAQTERTLEARERAHRQRVRGLEEQV---STLKGQLQQE 2000


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 157/749 (20%), Positives = 300/749 (40%), Gaps = 110/749 (14%)

Query: 395  LESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETIL 454
            LE+L+Q     +  L+  K +I S   +  L+       +E L+EQ  ERL  Q LE I 
Sbjct: 281  LETLQQRVKRQENLLKRCKETIQSHKEQCTLLT----SEKEALQEQLDERL--QELEKIK 334

Query: 455  SL-CAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDS 513
             L  AE TK  ++L       D + + ++LE+          ++ ++  +T+ + H    
Sbjct: 335  DLHMAEKTKLITQL------RDAKNLIEQLEQ----------DKGMVIAETKRQMHETLE 378

Query: 514  LPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPK 573
            + + ++A   S  +         +T+ +EL     ++         KA S +       +
Sbjct: 379  MKEEEIAQLRSRIKQM-------TTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431

Query: 574  TPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ 633
              +   +EQ        EE RI +   L  +KQ++ D+  +  E       + A L   Q
Sbjct: 432  KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEE------QIAKL---Q 482

Query: 634  KSETTEL-MKEKEILDHL---NRKIAELEKNIVGEKTKEKVKLDAEREKLE--RLQELYS 687
            K    EL  KE+E+   L    R+  E  K  + +   E +K+  E+E+ E   L+EL  
Sbjct: 483  KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELEL 542

Query: 688  EQKTQLDNCPESMREQLQQQLKRDADLLDVES---KHFEDLEFQQLEHESRLDEEKENLT 744
            ++K  L      +R+  Q+       +L++ES   K  ++ + Q  +    L+ EK    
Sbjct: 543  QKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHN 602

Query: 745  QQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENL 804
            +++   V +++  + S K +  AL  +   +++Q  + +   ++EK       ++EKE L
Sbjct: 603  KEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK------CEQEKETL 656

Query: 805  CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEP 864
                K    +       +N  TL++  +   E+        +LS        A     E 
Sbjct: 657  L---KDKEIIFQAHIEEMNEKTLEKLDVKQTELE-------SLSSELSEVLKARHKLEEE 706

Query: 865  ATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPK 924
             + +     + K+   +  + +K H +          ++  S I  H  S       T K
Sbjct: 707  LSVLKDQTDKMKQELEAKMDEQKNHHQ----------QQVDSIIKEHEVSIQR----TEK 752

Query: 925  AHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASES-- 982
            A     Q N         L  + K+ + + +     H +  E   ++SE   + AS    
Sbjct: 753  A--LKDQIN--------QLELLLKERD-KHLKEHQAHVENLEADIKRSEGELQQASAKLD 801

Query: 983  --NVYLNSFHYPDHSYKDQAFD----TLSLDSSDSMETSISACSPDNISSASTSNIARIE 1036
                Y ++ H    +Y++Q        L L++   + T   A          T   A   
Sbjct: 802  VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKI 861

Query: 1037 EMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKE- 1095
            +++ L++Q        LE +  EME K ++L +    +  LE   +E+   +Q L+EKE 
Sbjct: 862  QVQDLMQQ--------LEKQNSEMEQKVKSLTQVYESK--LEDGNKEQEQTKQILVEKEN 911

Query: 1096 --VKIRERQRAQARPLTRYLPVRKEDFDL 1122
              +++RE Q+ +   LT+ L  +++   +
Sbjct: 912  MILQMREGQKKEIEILTQKLSAKEDSIHI 940



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 139/752 (18%), Positives = 299/752 (39%), Gaps = 99/752 (13%)

Query: 409  LRERKSSISSISGRDDLMDYHRRQREERLREQE--MERLERQRLETI--LSLCAEYTKPD 464
            ++  K+ I S+    + +      +++   E+E  + +L+++  E I  ++L  E  K +
Sbjct: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELK-E 1364

Query: 465  SRLSTGTTVEDVQKINKELEK-LQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCG 523
             ++   +  + +  +N +L+  + LS++E+         D   +C   D + D       
Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEE-KCELLDQVQDLSF-KVD 1422

Query: 524  SLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQR 583
            +LS+   S       + D+  +  +       S F +  +    L I          E +
Sbjct: 1423 TLSKEKISALE----QVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI--------QLELK 1470

Query: 584  SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKE 643
            S+E    +E   ++   L++  ++   +  +M++   +++ + + L+ E KS+T  +M  
Sbjct: 1471 SKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM-- 1528

Query: 644  KEILDHLNRKIAELE------KNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP 697
             E+ DH+ +K  E+E      KN   +K  E  +L    +KL+  QEL  E+  ++    
Sbjct: 1529 -ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKEL---VQKLQHFQELGEEKDNRVKEAE 1584

Query: 698  ESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRN 757
            E +     Q     A+ L+ + K  E +       E  L   ++ L  +   ++AE +R 
Sbjct: 1585 EKILTLENQVYSMKAE-LETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKR- 1642

Query: 758  IVSRKEKISALKKQANHIVQQAQREQDHFVK----EKNNLIMMLQREKENLCNLEKKYSS 813
                ++KI+A+KKQ   ++ Q + +++ + K      + L   LQ  +  +  LE+K  S
Sbjct: 1643 --KAEQKIAAIKKQ---LLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKS 1697

Query: 814  LSGGKGFP-VNPNTLKE--GYISVNEI-NEPCGNST----------NLSPSTQFPADADA 859
            +   +    + P + K    Y    E  ++ C   T          NL+   +       
Sbjct: 1698 VESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ 1757

Query: 860  VATEPATAVLASQPQSKEHFRSLEERK-KQHKEGL---YLSDTL--PRKKTTSSISPHFS 913
               E  ++    + Q +E    LE  + KQH++     +L + L    KK +  ++ H  
Sbjct: 1758 EKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVE 1817

Query: 914  SATMGRSITPKAHL---------PLGQSNSCGSVLPPSL----AAMAKDSESRRM----- 955
                  +I  K +L          L +      +L   +    + + +  E  R+     
Sbjct: 1818 KEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEEL 1877

Query: 956  ---LRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSM 1012
                      Q  +G  + +E       E +          H  + +    +    +D +
Sbjct: 1878 TSKYEKLQALQQMDGRNKPTELLEENTEEKS--------KSHLVQPKLLSNMEAQHND-L 1928

Query: 1013 ETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLE---SREREMEAKKRALEE 1069
            E  ++    +         I R+++  R+L++ H ++  +L+    +ERE + K+   + 
Sbjct: 1929 EFKLAGAERE--KQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDL 1986

Query: 1070 EKRRREILEKRLQE-ETSQRQKLIEKEVKIRE 1100
            E +    L++ ++E  T   QK  E E+ I+E
Sbjct: 1987 ELKHNSTLKQLMREFNTQLAQKEQELEMTIKE 2018



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 161/816 (19%), Positives = 322/816 (39%), Gaps = 120/816 (14%)

Query: 395  LESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLE--RQRLET 452
            L+ L+Q   T    LRE+         +D  + +  +   E + E+ +E+L+  +  LE+
Sbjct: 631  LQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIF--QAHIEEMNEKTLEKLDVKQTELES 688

Query: 453  ILSLCAEYTKPDSRLSTGTTV--EDVQKINKELEKLQLSDEESVFEEALMS--PDTRYRC 508
            + S  +E  K   +L    +V  +   K+ +ELE  ++ ++++  ++ + S   +     
Sbjct: 689  LSSELSEVLKARHKLEEELSVLKDQTDKMKQELEA-KMDEQKNHHQQQVDSIIKEHEVSI 747

Query: 509  HRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYL 568
             R +      +     L +             + L +D+ R+         K     SY 
Sbjct: 748  QRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQ 807

Query: 569  SILPKTPEGISEE--QRSQELAAMEETRIVILNNLEELKQKIKDI--------------- 611
            S   +  +   E+  Q  Q+L  +E  RI++   + E++ + KD+               
Sbjct: 808  SATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLM 867

Query: 612  ------NDQMDESFRELDM--ECALLDGEQKSETT-ELMKEKEIL------------DHL 650
                  N +M++  + L    E  L DG ++ E T +++ EKE +            + L
Sbjct: 868  QQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEIL 927

Query: 651  NRKIAELEKNIV------------GEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPE 698
             +K++  E +I              EK  EKVK  A +E  E L++   +Q+ +L    E
Sbjct: 928  TQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKA-KEMQETLKKKLLDQEAKLKKELE 986

Query: 699  SMREQLQQQLKR-DADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRN 757
            +   +L Q+ K+ +A +L++   +   +       E+   E+ E+LT+   RE+ +   +
Sbjct: 987  NTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDV-IS 1045

Query: 758  IVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGG 817
            I  +K    A + Q  H +Q  ++EQ+  V E    I++   EKE + N E  +    G 
Sbjct: 1046 IWEKKLNQQAEELQEIHEIQLQEKEQE--VAELKQKILLFGCEKEEM-NKEITWLKEEG- 1101

Query: 818  KGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKE 877
                V  +T      ++NE+ E            Q  A  +++A +        + + K 
Sbjct: 1102 ----VKQDT------TLNELQEQL---------KQKSAHVNSLAQD--------ETKLKA 1134

Query: 878  HFRSLE-ERKKQHKEGLYLSDTLPRKKTTSSISPH-FSSATMGRSITPKAHLPLGQSN-- 933
            H   LE +  K  KE  +L + L   K  +       S  T     T +    L  S+  
Sbjct: 1135 HLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEK 1194

Query: 934  SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPD 993
            S  S+   SL       E    L     +  +    + +E  N ++S++N  L+   +  
Sbjct: 1195 SNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQ 1254

Query: 994  HSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLL 1053
            H             +       I  C+   +     + + ++ E +  L  +  + T  L
Sbjct: 1255 HR-----------TTKVKEALLIKTCTVSELE----AQLRQLTEEQNTLNISFQQATHQL 1299

Query: 1054 ESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYL 1113
            E +E ++++ K  +E     +E L+K   E  +Q+Q   EKE  I + ++  +  +    
Sbjct: 1300 EEKENQIKSMKADIESLVTEKEALQK---EGGNQQQAASEKESCITQLKKELSENINAVT 1356

Query: 1114 PVRKEDFDLRSHVETAGH-----NIDTCYHVSITEK 1144
             +++E  + +  + +        N+     +S++EK
Sbjct: 1357 LMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 81/431 (18%), Positives = 184/431 (42%), Gaps = 50/431 (11%)

Query: 392  EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 451
            +A+LE+ ++       +++ ++  + ++  R +     +    +R  EQ++  +++Q L 
Sbjct: 1598 KAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLS 1657

Query: 452  TILSLCAEYTK-PDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHR 510
             +     +Y K  +S LS   T    ++    + + +L   ES   E L+ P +      
Sbjct: 1658 QMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAA 1717

Query: 511  KDSLPDADLASCGSLS-QSSASFFTPRSTRNDELLSDLTRTPPPP-SSTFPKASSESSYL 568
                 +AD   C   + +   S      T  ++LL  + +      SS F         L
Sbjct: 1718 YTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERL 1777

Query: 569  --------------SILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQ 614
                          S++    E + E+ +   L   +        N  + KQ ++++ D 
Sbjct: 1778 IKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDD 1837

Query: 615  MDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLD- 673
            + ++ +E ++ C +L+                     +KI EL+  +V +K   +V+++ 
Sbjct: 1838 VQKTLQEKELTCQILE---------------------QKIKELDSCLVRQKEVHRVEMEE 1876

Query: 674  --AEREKLERLQELYSEQK-TQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL 730
              ++ EKL+ LQ++    K T+L    E+  E+ +  L +   L ++E++H  DLEF+  
Sbjct: 1877 LTSKYEKLQALQQMDGRNKPTEL--LEENTEEKSKSHLVQPKLLSNMEAQH-NDLEFKL- 1932

Query: 731  EHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQAN-HIVQQAQREQDHFVKE 789
               +  + EK+ L ++++R   + +      ++++  LKK+ +    ++ ++EQ+    +
Sbjct: 1933 ---AGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELK 1989

Query: 790  KNNLIMMLQRE 800
             N+ +  L RE
Sbjct: 1990 HNSTLKQLMRE 2000



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 115/621 (18%), Positives = 247/621 (39%), Gaps = 78/621 (12%)

Query: 574  TPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ 633
            T + I  E  ++ L    + + +    L +  Q  +++ ++ D   +E + +   L+ + 
Sbjct: 1535 TQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQV 1594

Query: 634  KSETTELMKEKEILDHLN-------RKIAELEKNIVGE--------KTKEKVKLDA-ERE 677
             S   EL  +K+ L+H+N        ++  LE  +  E        K K + K+ A +++
Sbjct: 1595 YSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQ 1654

Query: 678  KLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL------E 731
             L +++E   + K   ++    +  +LQ++ +R+  +L+ + K  E  + + L      +
Sbjct: 1655 LLSQMEEKEEQYKKGTESHLSELNTKLQER-EREVHILEEKLKSVESSQSETLIVPRSAK 1713

Query: 732  HESRLDEEKENLTQQLLREVAE-----YQRNIVSRKEKISALKKQ-----ANHIVQQAQR 781
            + +   E++E  +Q  +++  E      QRN+  +++ +  + ++     ++H   + Q 
Sbjct: 1714 NVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY 1773

Query: 782  EQ-----DHFVKEKNNLIMMLQREKENLCNLEKKYSSL-------SGGKGFPVNPNTLKE 829
            ++     +H   +++    M+   +E L    KKYS +        GGK        L+ 
Sbjct: 1774 QERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLEN 1833

Query: 830  GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSK-EHFRSLEERKKQ 888
             +  V +  +    +  +        D+  V  +    V   +  SK E  ++L++   +
Sbjct: 1834 VFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGR 1893

Query: 889  HKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAK 948
            +K    L +    K  +  + P   S    +    +  L   +       L   +  + K
Sbjct: 1894 NKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREK--QKLGKEIVRLQK 1951

Query: 949  DSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDS 1008
            D    RMLR  + Q++    ++  +       +    L   H        + F+T     
Sbjct: 1952 DL---RMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008

Query: 1009 SDSMETSISACSPDNISSASTSNIARIE----EMERLLKQAHAEK-----------TRLL 1053
               +E +I     + I+ A       +E    E  +LLK+  AEK             +L
Sbjct: 2009 EQELEMTIK----ETINKAQEVEAELLESHQEETNQLLKKI-AEKDDDLKRTAKRYEEIL 2063

Query: 1054 ESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYL 1113
            ++RE EM AK R L+ +    E L+K+ Q++  Q +      V I E Q   A+  T   
Sbjct: 2064 DAREEEMTAKVRDLQTQ---LEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLIS 2120

Query: 1114 PVRKEDFDLRSHVETAGHNID 1134
              + ++ + R  +    HN++
Sbjct: 2121 DSKLKEQEFREQI----HNLE 2137



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 92/449 (20%), Positives = 184/449 (40%), Gaps = 51/449 (11%)

Query: 391 DEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLR-EQEMERLERQR 449
           + A  E L +A  T Q     R+   + +   + +    +   EER+  +QE+ R++++ 
Sbjct: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMD--EQIKTIEKTSEEERISLQQELSRVKQEV 466

Query: 450 LETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCH 509
           ++ +     E      +L         Q++ K+L+  +   +E + + AL    + Y   
Sbjct: 467 VDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQM-KVALEKSQSEYLKI 525

Query: 510 RKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPP-------SSTFPKAS 562
            ++      LA      Q  A       T ++  L DL +             S+  K+ 
Sbjct: 526 SQEKEQQESLALEELELQKKAIL-----TESENKLRDLQQEAETYRTRILELESSLEKSL 580

Query: 563 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELK-----QKIKDINDQMDE 617
            E+   S          + + ++E+  M E     L +L+  +     +K++ +  Q   
Sbjct: 581 QENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQT 640

Query: 618 SFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAERE 677
              +L  +C     EQ+ ET  L+K+KEI+       A +E+  + EKT EK  LD ++ 
Sbjct: 641 EMEKLREKC-----EQEKET--LLKDKEIIFQ-----AHIEE--MNEKTLEK--LDVKQT 684

Query: 678 KLERLQELYSEQKTQLDNCPESMR------EQLQQQLKRDADLLDVESKHFEDLEFQQLE 731
           +LE L    SE         E +       ++++Q+L+   D  + ++ H + ++    E
Sbjct: 685 ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMD--EQKNHHQQQVDSIIKE 742

Query: 732 HESRLDEEKENLTQQ------LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDH 785
           HE  +   ++ L  Q      LL+E  ++ +   +  E + A  K++   +QQA  + D 
Sbjct: 743 HEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDV 802

Query: 786 FVKEKNNLIMMLQREKENLCNLEKKYSSL 814
           F   ++      +  +E L  L++K   L
Sbjct: 803 FQSYQSATHEQTKAYEEQLAQLQQKLLDL 831



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 115/532 (21%), Positives = 216/532 (40%), Gaps = 62/532 (11%)

Query: 602  EELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMK-EKEILDHLNRKIAELEKN 660
            + L+ K  +     +E   +LD+ C   +   +++T EL+       + +  +I+  +  
Sbjct: 1197 KSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHR 1256

Query: 661  IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
                K    +K     E   +L++L  EQ T   +  ++  +  +++ +  +   D+ES 
Sbjct: 1257 TTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESL 1316

Query: 721  HFEDLEFQQLE-HESRLDEEKENLTQQLLREVAE-------YQRNIVSRKEKISALKKQA 772
              E    Q+   ++ +   EKE+   QL +E++E        +  +  +K +IS+L KQ 
Sbjct: 1317 VTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQL 1376

Query: 773  NHIVQQAQREQDHFVKEKNNLIMMLQRE-KENLCNLEKKYSSLSGGKGFPVNPNTLKEGY 831
              +  Q Q      + EK   I  L+++  E  C L  +   LS    F V+  TL +  
Sbjct: 1377 TDLNVQLQNSIS--LSEKEAAISSLRKQYDEEKCELLDQVQDLS----FKVD--TLSKEK 1428

Query: 832  ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQ----SKEHFRS------ 881
            IS  E  +   N  +     ++   A +  T+    V   Q Q    SKE +        
Sbjct: 1429 ISALEQVDDWSNKFS-----EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINL 1483

Query: 882  -LEERKKQHK-----EGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLG--QSN 933
              EE  +Q+K     +G    D    +K  S++     S T  R +  + H+     +  
Sbjct: 1484 LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQT-ARIMELEDHITQKTIEIE 1542

Query: 934  SCGSVLPPSLAAMAKDSESRRMLRGYNH-QQMSE--GHRQKSEFYNRTASESNVYLNSFH 990
            S   VL        KD E + +++   H Q++ E   +R K         E+ VY     
Sbjct: 1543 SLNEVLKNY--NQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMK-- 1598

Query: 991  YPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM---------ERL 1041
              +   K +  + ++L S  S E  + A   D + S S + +A ++           ++L
Sbjct: 1599 -AELETKKKELEHVNL-SVKSKEEELKALE-DRLESESAAKLAELKRKAEQKIAAIKKQL 1655

Query: 1042 LKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQE-ETSQRQKLI 1092
            L Q   ++ +  +  E  +      L+E +R   ILE++L+  E+SQ + LI
Sbjct: 1656 LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLI 1707



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 139/739 (18%), Positives = 275/739 (37%), Gaps = 89/739 (12%)

Query: 428  YHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQ 487
            +    +E  +R    E L R  L+   S  A +  P    S     ED+   +  L K Q
Sbjct: 85   FRSSSKESLVRTSSRESLNRLDLD---SSTASFDPPSDMDSEA---EDLVGNSDSLNKEQ 138

Query: 488  LSDEESVFEEALMSPDTRYR--CHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLS 545
            L       E +L S   +Y         L        G LSQS        +   +EL  
Sbjct: 139  LIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQM 198

Query: 546  DLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELK 605
            D                 +  Y+S+L      + +  R+  +       + +L  L +L+
Sbjct: 199  DQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPM------NVDVLKPLPQLE 252

Query: 606  QKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN----- 660
             + +    + +    E D E  + DG        L +  +  ++L ++  E  ++     
Sbjct: 253  PQAEVFTKEENP---ESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQC 309

Query: 661  --IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVE 718
              +  EK   + +LD   ++LE++++L+  +KT+L       +  L +QL++D  ++  E
Sbjct: 310  TLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAK-NLIEQLEQDKGMVIAE 368

Query: 719  SKH--FEDLEFQQLEHESRLDEEKENLTQ--QLLREVAEYQRNIVSRKEKISALKKQANH 774
            +K    E LE ++ E        K+  TQ  +L  +  + +R      EK  +  ++   
Sbjct: 369  TKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEE 428

Query: 775  IVQQAQREQDHFVK--------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNT 826
              ++ + E D  +K        E+ +L   L R K+ + ++ KK S              
Sbjct: 429  ARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS-------------- 474

Query: 827  LKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERK 886
             +E    + +++E            +          E    +  +  +S+  +  + + K
Sbjct: 475  -EEQIAKLQKLHE----KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEK 529

Query: 887  KQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAM 946
            +Q +E L L +   +KK   +      S    R +  +A     +     S L  SL   
Sbjct: 530  EQ-QESLALEELELQKKAILT-----ESENKLRDLQQEAETYRTRILELESSLEKSLQEN 583

Query: 947  AKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSL 1006
               S+    L  +   + ++ +++ +    +  +E    L S  +   +   +    L  
Sbjct: 584  KNQSKD---LAVHLEAEKNKHNKEITVMVEKHKTE----LESLKHQQDALWTEKLQVLKQ 636

Query: 1007 DSSDSMETSISACSPDNISSASTSNI---ARIEEM-ERLLKQAHAEKTRL--LESREREM 1060
                 ME     C  +  +      I   A IEEM E+ L++   ++T L  L S   E+
Sbjct: 637  QYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEV 696

Query: 1061 EAKKRALEEE--------KRRREILEKRLQEETSQRQKLI-----EKEVKIRERQRAQAR 1107
               +  LEEE         + ++ LE ++ E+ +  Q+ +     E EV I+  ++A   
Sbjct: 697  LKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKD 756

Query: 1108 PLTRY-LPVRKEDFDLRSH 1125
             + +  L +++ D  L+ H
Sbjct: 757  QINQLELLLKERDKHLKEH 775



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 46/194 (23%), Positives = 93/194 (47%), Gaps = 13/194 (6%)

Query: 568  LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMEC- 626
            L IL K  +   EE+  QE   +E      L +   LKQ +++ N Q+ +  +EL+M   
Sbjct: 1964 LEILKKEYDQEREEKIKQEQEDLE------LKHNSTLKQLMREFNTQLAQKEQELEMTIK 2017

Query: 627  ALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDA-EREKLERLQEL 685
              ++  Q+ E   L   +E  + L +KIAE + ++     + +  LDA E E   ++++L
Sbjct: 2018 ETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDL 2077

Query: 686  YSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEK-ENLT 744
                +TQL+   +  +++L+Q+     D + +     +  +   L  +S+L E++     
Sbjct: 2078 ----QTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQI 2133

Query: 745  QQLLREVAEYQRNI 758
              L   + +Y++N+
Sbjct: 2134 HNLEDRLKKYEKNV 2147


>gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
          Length = 1154

 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 172/818 (21%), Positives = 312/818 (38%), Gaps = 138/818 (16%)

Query: 392  EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 451
            +A+++SLRQA+   + +  E +S I+S+  ++DL    R Q E     ++MER+      
Sbjct: 147  QAEIQSLRQAA---EDSATEHESDIASL--QEDLC---RMQNEL----EDMERIRGDYEM 194

Query: 452  TILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQ-----LSDEESVFEEALMS----- 501
             I SL AE     S  S    + D   + +EL++L+     L++E    +E+  S     
Sbjct: 195  EIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQL 254

Query: 502  ---PDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTF 558
                  R +   +  L    L+   + SQ+S   F         L   L           
Sbjct: 255  ADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMK 314

Query: 559  PKASSESSYLSILPKTPEGISEEQR---------SQELAAMEETRIVILNNLEELKQKI- 608
             K       L  L    +   EEQR           E+   + +  V  N  EELK ++ 
Sbjct: 315  NKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQN--EELKSRLC 372

Query: 609  ---KDINDQMDESFRELDMECALLDGEQ-----KSETTELMKEKEILDHLNRKIAELEKN 660
               K  +   DE    L M+  L    +     KS   E   EKE+L  L +K+    +N
Sbjct: 373  TLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRL-QKLHLQHQN 431

Query: 661  IVGEKTKEKVKLDAEREKLE----RLQELYS-----EQKTQLDNCPESMREQLQQQLKRD 711
            +  EK K   +    +E+L+     LQ L       ++  + D    +  ++++Q  +  
Sbjct: 432  VTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQAS 491

Query: 712  ADLLDVESKHFED----------LEFQQLEHESRLDEEK---ENLTQQLLREVAEYQRNI 758
             D L+   KH  D          LE ++L+    + E+K    N    LL  + E Q   
Sbjct: 492  KDELE-RQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKY 550

Query: 759  VSRKEKISALKKQANHIVQQAQR---EQDHFVKEKNNLIMMLQR------------EKEN 803
             + ++++  L+ +   +++  +R   EQ    +E + L + L +            + E+
Sbjct: 551  KASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLED 610

Query: 804  LCNLEKKYSSLSGG-KGFPVNPNTLKEGYISVNE----INEPCGNSTNLSPSTQFPADAD 858
            LC L+  Y  +    K    N + + +  + ++E      E        +P     A + 
Sbjct: 611  LCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSS 670

Query: 859  AVATEPATAVLASQPQSKEHFRSLEERKK---QHKEGLYLSDTLPRKKTTSSISPHFSSA 915
                   + +L  Q Q+ +      + K+   Q ++G  L +   RK+  + +       
Sbjct: 671  KCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEE---RKRLQADLQLCLEEM 727

Query: 916  TMGRSITPKAHLPL-GQSNSCGSVLPPS------LAAMAKDSESRRMLRGYNHQQMSEGH 968
             + +  +P   + L     S GS++P +            D+ES    + Y   Q S   
Sbjct: 728  QLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNES--YYKSYTSTQTSSKS 785

Query: 969  RQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSAS 1028
              KS  Y+ + S S  Y  S+    +S       +++   S    +S   C    +SS +
Sbjct: 786  FLKS--YDSSTSASEAYGKSYCTTSNS-------SITYKKSYGSTSSSDTCQKSFVSSCT 836

Query: 1029 TSNIARIEEMERL----------------LKQAHAEKTRLLESREREMEAKKRALEEE-- 1070
                A  E+MER                 + Q   E+   L+ +  ++ AK++ L+EE  
Sbjct: 837  DEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELD 896

Query: 1071 ------KRRREILEKRLQEETSQRQKLIEKEVKIRERQ 1102
                  K   E LEK +  + + + ++ E + K+RE Q
Sbjct: 897  ACEREFKECMECLEKPMAPQ-NDKNEIKELQTKLRELQ 933



 Score = 38.5 bits (88), Expect = 0.041
 Identities = 67/291 (23%), Positives = 117/291 (40%), Gaps = 32/291 (10%)

Query: 428 YHRRQREERLREQEMERL--ERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEK 485
           Y   Q ++ L +QE  RL  ER+RL+  L LC               +E++Q +  +   
Sbjct: 692 YDAGQAKQELLQQEQGRLLEERKRLQADLQLC---------------LEEMQLLQVQSPS 736

Query: 486 LQLSDEESVFEEALMSPDTRYRCHRKDSLPDAD---LASCGSLSQSSASFFT--PRSTRN 540
           +++S E        M P         D+  D +     S  S   SS SF      ST  
Sbjct: 737 IKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSA 796

Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
            E       T    S T+ K+   +S      K+      ++   E   ME    +++  
Sbjct: 797 SEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKV 856

Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL----MKEKEILDHLNRKIA- 655
           L +L Q ++ +     E   +L  +   L  +QK    EL     + KE ++ L + +A 
Sbjct: 857 LIKL-QAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAP 915

Query: 656 ELEKNIVGE---KTKE-KVKLDAEREKLERLQELYSEQKTQLDNCPESMRE 702
           + +KN + E   K +E +++  A  ++  RL  +  + + QL  C E +R+
Sbjct: 916 QNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQ 966


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 156/764 (20%), Positives = 300/764 (39%), Gaps = 108/764 (14%)

Query: 386  GSVEFDEADLESLRQASGTPQPA---LRERKSSISSISGR--DDLMDYHRRQREERLREQ 440
            G V    A+L+SL Q     Q     +++ K      + +   ++ D   +  EER   +
Sbjct: 128  GLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE 187

Query: 441  EMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 500
              E+   +  E +           + L     +EDV  + KEL ++Q           LM
Sbjct: 188  AAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQ----------TLM 237

Query: 501  SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPK 560
               T  R    + L D     C  L    AS     S    +L S+L + P   +    +
Sbjct: 238  DNMTLERERESEKLKD----ECKKLQSQYASSEATIS----QLRSELAKGPQEVAVYVQE 289

Query: 561  ASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFR 620
                 S ++ L +  + ++E    +E    + T++   +N E + +K       +  +  
Sbjct: 290  LQKLKSSVNELTQKNQTLTENLLKKE---QDYTKLEEKHNEESVSKK------NIQATLH 340

Query: 621  ELDMECALLDGEQKSETT-------ELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLD 673
            + D++C  L     +  T       EL ++ E    L  +++E+E      K + K +L 
Sbjct: 341  QKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFK-QLQ 399

Query: 674  AEREKLER--------LQELYS---EQKTQLDNCPESMREQLQQQLKRDADLLDVESKHF 722
             +RE+ E+        + +L+S   E + QL      ++EQ Q   ++   L+D E +  
Sbjct: 400  QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEK---LMDKEQQ-V 455

Query: 723  EDLEFQQLEHESRLDEEKENLT--QQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
             DL+ +    E +L E+  N T  Q  L +  +  +   + ++  +A  ++A + ++Q  
Sbjct: 456  ADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVL 515

Query: 781  REQDHFVKEKNNLIMMLQREKENLCNLEKK----YSSLSGGKGFPVNPNTLKEGYISVNE 836
            R+     ++  NL  +LQ+ KEN+  LEK+    Y+ +  G+G     N L+E   ++ E
Sbjct: 516  RQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQE 575

Query: 837  INEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEER----------- 885
                    T L+   +  +++   A E     +  Q   K H R+ ++R           
Sbjct: 576  ------QVTQLTEKLKNQSESHKQAQENLHDQVQEQ---KAHLRAAQDRVLSLETSVNEL 626

Query: 886  ---KKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPS 942
                 + KE +   D   + KT   +S    +A   +    + HL   Q+          
Sbjct: 627  NSQLNESKEKVSQLDIQIKAKTELLLSA--EAAKTAQRADLQNHLDTAQN---------- 674

Query: 943  LAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFD 1002
             A   K  E  ++    +  Q++   + K E  ++  S    Y   +   +   ++    
Sbjct: 675  -ALQDKQQELNKITTQLD--QVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQ 731

Query: 1003 TLSLDSSDSMETSIS-ACSPDNISSASTSNIARIEEMERLLKQAHAEK-----TRL-LES 1055
               L+ +DS+E   S   +  ++      N         L KQ   EK     TRL L+ 
Sbjct: 732  IKKLE-ADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQK 790

Query: 1056 REREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIR 1099
            +   +E+ K+ L +++  ++IL++   E  SQ  K+  +E+  R
Sbjct: 791  KSEALESIKQKLTKQEEEKQILKQDF-ETLSQETKIQHEELNNR 833



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 142/703 (20%), Positives = 277/703 (39%), Gaps = 111/703 (15%)

Query: 431  RQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQ-KINKELEKL-QL 488
            +Q +E L +Q  E+    R              D  LS  T+V ++  ++N+  EK+ QL
Sbjct: 592  KQAQENLHDQVQEQKAHLR-----------AAQDRVLSLETSVNELNSQLNESKEKVSQL 640

Query: 489  SDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLT 548
              +     E L+S +      R D     D A   +  Q         +T+ D++ + L 
Sbjct: 641  DIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQ--NALQDKQQELNKITTQLDQVTAKLQ 698

Query: 549  RTPPPPSSTFPKASS-ESSYLSILPKTPEGISE----EQRSQELAAMEETRIVILNNLEE 603
                  S         +  YLS+  KT E   +    E  S E+ A +E     L +L++
Sbjct: 699  DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA---LQDLQQ 755

Query: 604  LKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVG 663
             +Q   D+  +  E  ++L+ME  ++     S   +L K+ E L+ + +K+         
Sbjct: 756  QRQLNTDLELRATELSKQLEMEKEIVS----STRLDLQKKSEALESIKQKL--------- 802

Query: 664  EKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFE 723
              TK++ +    ++  E L +    Q  +L+N  ++   +LQ+ +K + + L  E     
Sbjct: 803  --TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK-VKMEKEALMTEL---- 855

Query: 724  DLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQ 783
                      S + ++   ++  L    +E+++     K  I  L+K    +  Q Q + 
Sbjct: 856  ----------STVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM 905

Query: 784  DHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGN 843
            ++ +KE+  L   L++EKE    L+ + +S+   +      NTLK+   +  E  +  GN
Sbjct: 906  ENTLKEQKELKKSLEKEKEASHQLKLELNSMQ--EQLIQAQNTLKQ---NEKEEQQLQGN 960

Query: 844  STNLSPST-QFPADADAVATEPATAVL---------------ASQPQSKE---------H 878
               L  S+ Q     +A+  E   AVL               A+Q  + E         +
Sbjct: 961  INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020

Query: 879  FRSLEERKKQHKEGLY--LSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCG 936
            +   +E  KQ +   Y   S+ L  ++   S+    S   + +         +G  N   
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLS---LAQEDLISNRNQIGNQNKLI 1077

Query: 937  SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSY 996
              L  + A + +DS  +        QQ+ E  +   +     + +    +N         
Sbjct: 1078 QELKTAKATLEQDSAKK-------EQQLQERCKALQDIQKEKSLKEKELVNE-------- 1122

Query: 997  KDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESR 1056
            K +  +   +      E +       +    S   I  +++ ++LL Q   E        
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE-------L 1175

Query: 1057 EREMEAKKRALEEEKRRREILEKRL-QEETSQRQKLIEKEVKI 1098
            + + ++ K A+E+EKR ++IL+ ++ +EE   +++ IEKE K+
Sbjct: 1176 QGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKL 1218



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 94/447 (21%), Positives = 194/447 (43%), Gaps = 45/447 (10%)

Query: 396  ESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLERQ-RLET 452
            ES +QA       ++E+K+ + +   R   ++    +   +L E  +++ +L+ Q + +T
Sbjct: 589  ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKT 648

Query: 453  ILSLCAEYTKPDSR------LSTGTTV-----EDVQKINKELEKL--QLSDEE---SVFE 496
             L L AE  K   R      L T         +++ KI  +L+++  +L D++   S  E
Sbjct: 649  ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLE 708

Query: 497  EALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSS 556
              L     +Y      SL        G + +  A     ++++ ++ L DL +     + 
Sbjct: 709  SHLKEYKEKYL-----SLEQKTEELEGQIKKLEADSLEVKASK-EQALQDLQQQRQLNTD 762

Query: 557  TFPKASSESSYLSI-----------LPKTPEGISEEQRSQELAAMEETRIVILNNLEELK 605
               +A+  S  L +           L K  E +  E   Q+L   EE + ++  + E L 
Sbjct: 763  LELRATELSKQLEMEKEIVSSTRLDLQKKSEAL--ESIKQKLTKQEEEKQILKQDFETLS 820

Query: 606  QKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEK 665
            Q+ K  +++++   +    E   +  E+++  TEL   K+ L     K+++  KN   E 
Sbjct: 821  QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS----KVSDSLKNSKSEF 876

Query: 666  TKEKVKLDAEREKLERL-QELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFED 724
             KE  K  A    LE+  +EL  + + Q++N  +  +E L++ L+++ +           
Sbjct: 877  EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE-LKKSLEKEKEASHQLKLELNS 935

Query: 725  LEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQD 784
            ++ Q ++ ++ L ++ E   QQL   + E +++   +K++I AL+ +    V Q    ++
Sbjct: 936  MQEQLIQAQNTL-KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN 994

Query: 785  HFVKEKNNLIMMLQREKENLCNLEKKY 811
               ++       L  EKE +  L+  Y
Sbjct: 995  KLQQQLTQAAQELAAEKEKISVLQNNY 1021



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 106/537 (19%), Positives = 219/537 (40%), Gaps = 60/537 (11%)

Query: 393  ADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE------ERLREQEMERLE 446
            A L+  ++     +  L+E K    S+  + + ++   ++ E      +  +EQ ++ L+
Sbjct: 695  AKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQ 754

Query: 447  RQR-LETILSLCAEYTKPDSRLS---TGTTVEDVQKINKELEKLQLS-----DEESVFEE 497
            +QR L T L L A        +      +T  D+QK ++ LE ++       +E+ + ++
Sbjct: 755  QQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQ 814

Query: 498  AL--MSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPS 555
                +S +T+ +    ++     +     +     +  T  ST  D+L S ++ +     
Sbjct: 815  DFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL-SKVSDSLKNSK 873

Query: 556  STFPKASSESSYLSI-LPKTPEGISEEQRSQELAAMEETRIVILNNLE-------ELKQK 607
            S F K + +     + L KT + +  + + Q    ++E +  +  +LE       +LK +
Sbjct: 874  SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK-ELKKSLEKEKEASHQLKLE 932

Query: 608  IKDINDQM---DESFRELDMECALLDG---EQKSETTELMKEKEILDHLNRKIAELEKNI 661
            +  + +Q+     + ++ + E   L G   E K  + +  K+ E L     KIA L+K  
Sbjct: 933  LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG-ELKIAVLQKTE 991

Query: 662  VGEKTKEKV-----KLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLD 716
            +  K ++++     +L AE+EK+  LQ  Y + +            +  + L    DL  
Sbjct: 992  LENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKS 1051

Query: 717  VESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIV 776
            VE K    L  + L         +  L Q+L    A  +++   +++++    K    I 
Sbjct: 1052 VEEK--LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQ 1109

Query: 777  QQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNE 836
            ++   ++   V EK+ L  +    +E  C  EK+ + L        N         S+ E
Sbjct: 1110 KEKSLKEKELVNEKSKLAEI----EEIKCRQEKEITKL--------NEELKSHKLESIKE 1157

Query: 837  INEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGL 893
            I       TNL  + Q            A ++ A+  Q K + + L+++ K+ +E L
Sbjct: 1158 I-------TNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL 1207



 Score = 53.9 bits (128), Expect = 9e-07
 Identities = 52/207 (25%), Positives = 102/207 (49%), Gaps = 23/207 (11%)

Query: 601  LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
            ++ELK     +     +  ++L   C  L   QK ++   +KEKE+++  + K+AE+E+ 
Sbjct: 1077 IQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKS---LKEKELVNEKS-KLAEIEE- 1131

Query: 661  IVGEKTKEKVKLDAERE--KLERLQELYS---------EQKTQLDNCPESMREQLQQQLK 709
            I   + KE  KL+ E +  KLE ++E+ +         +QK +L    +S++  ++Q+ +
Sbjct: 1132 IKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKR 1191

Query: 710  RDADLLDVESKHFEDLEFQQLEHESRLD---EEKENLTQQLLREVAEYQRNIVSRKEKIS 766
                L D   K  E+L+ + +E E++L    +EKE   ++     A+    I +  E + 
Sbjct: 1192 NQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLG 1251

Query: 767  ALKKQANHIVQQAQREQDHFVKEKNNL 793
             +KK+     Q +QR      K+ ++L
Sbjct: 1252 TVKKE----WQSSQRRVSELEKQTDDL 1274



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 128/710 (18%), Positives = 269/710 (37%), Gaps = 78/710 (10%)

Query: 474  EDVQKINKELEKLQLS-DEESVFEEALMSPDTRYR-CHRKDSLPDADLASCGSLSQSSAS 531
            +DV  + +E++ LQ S  EE  + E L     +Y+   ++++ PD  +    +  QS   
Sbjct: 83   DDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQ 142

Query: 532  FFTPRSTRNDEL--LSDLTRTPPPPSSTF-----PKASSESSYLSILPKTPEGISEEQRS 584
                  T N  +  + DL        +T       K   E S      +    ++EE   
Sbjct: 143  QLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNK 202

Query: 585  QELAAME-ETRIVILNNLEE---LKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640
            +     + +T ++    +E+   LK+++  +   MD    E + E   L  E K   ++ 
Sbjct: 203  EATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQY 262

Query: 641  MKEKEILDHLNRKIAELEKNI---VGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP 697
               +  +  L  ++A+  + +   V E  K K  ++   +K + L E   +++       
Sbjct: 263  ASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLE 322

Query: 698  ESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDE-----------EKENLTQQ 746
            E   E+   +    A L      H +DL+ QQL+      E           EK   TQ+
Sbjct: 323  EKHNEESVSKKNIQATL------HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK 376

Query: 747  LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCN 806
            L  E++E +        K   LK +   + QQ + ++ H ++ ++ +  +  +  E    
Sbjct: 377  LKEELSEVET-------KYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ 429

Query: 807  LEKKYSSLSGGKGFPVNPNTLKEGYIS---------VNEINEPCGNSTNLS----PSTQF 853
            L + +  L   +         KE  ++           ++ E   NST L      + Q 
Sbjct: 430  LGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ 489

Query: 854  PADADAVATEPATAVLASQPQSKEHFRSL--EERKKQHKEGLYLSDTLPRKKTTSSISPH 911
              +  A+       +  +Q   ++  R +  +++K Q+ E L                  
Sbjct: 490  HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDL 549

Query: 912  FSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQK 971
            ++    G   T   +    ++++    +      +   SES +  +   H Q+ E     
Sbjct: 550  YAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHL 609

Query: 972  SEFYNRTAS-ESNVYLNSFHYPDHSYKDQAFD------TLSLDSSDSMETSISACSPDNI 1024
                +R  S E++V   +    +   K    D      T  L S+++ +T+  A   +++
Sbjct: 610  RAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHL 669

Query: 1025 SSASTSNIARIEEMERLLKQAHAEKTRL---------LESREREMEAKKRALEEEKRRRE 1075
             +A  +   + +E+ ++  Q      +L         LES  +E + K  +LE++    E
Sbjct: 670  DTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELE 729

Query: 1076 ILEKRLQEETSQRQKLIEKEVKIRERQR-------AQARPLTRYLPVRKE 1118
               K+L+ ++ + +   E+ ++  ++QR        +A  L++ L + KE
Sbjct: 730  GQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKE 779


>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
            [Homo sapiens]
          Length = 1388

 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 117/562 (20%), Positives = 238/562 (42%), Gaps = 59/562 (10%)

Query: 584  SQELAAMEETRIVILNNLEELKQKIKDINDQ---MDESFRELDMECALLDGEQKSETTEL 640
            S   A + +T+      +++L+   +D+ D+   ++ +  +L+ E   L    +SE  + 
Sbjct: 575  SDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDR 634

Query: 641  MKEKEILDHLNRKIAELEKNIV-GEKTKEKVKLDAEREKLERLQELYSEQKT-------Q 692
                EI++ L  +I  LE+++  G+    KV+L+ +R+  ER  +L  E+         Q
Sbjct: 635  THGSEIINDLQGRICGLEEDLKNGKILLAKVELE-KRQLQERFTDLEKEKSNMEIDMTYQ 693

Query: 693  LDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVA 752
            L    +S+ ++  +     A L D ++K +E +E  + + E+  + EK+ L ++ L++  
Sbjct: 694  LKVIQQSLEQEEAEHKATKARLAD-KNKIYESIE--EAKSEAMKEMEKKLLEERTLKQKV 750

Query: 753  EYQRNIVSRKEKISALK----KQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 808
            E   N++   EK  +L     KQ+   + +  +++D   ++  NL + +++E +  C  +
Sbjct: 751  E---NLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQ 807

Query: 809  KKYSSLSGGKGFPVNPNTLKEGYISVN-EINEPCGNSTNLSPST----QFPADADAVATE 863
                  +         NTLK     +  E N       NL        +   DAD    E
Sbjct: 808  NDLKMQTQ------QVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKE 861

Query: 864  PATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITP 923
                + A Q  S  +   + E K++ +E   L   L +KK          +A +  ++T 
Sbjct: 862  LQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTK 921

Query: 924  KAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTAS--- 980
                 L +S +              D E  ++++    ++M   H+Q+    + T +   
Sbjct: 922  ADSEQLARSIA---------EEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLE 972

Query: 981  ESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-- 1038
            E+N  L S      + K++  + L       ++  +S    + IS+A+    A+ E+   
Sbjct: 973  ETNRTLTSDVANLANEKEELNNKLK-----DVQEQLSRLKDEEISAAAIK--AQFEKQLL 1025

Query: 1039 -ERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEET-SQRQKLIEKEV 1096
             ER LK     K   + +R+   E  KR  + + RR+E   ++L  E  S+R+KL ++ +
Sbjct: 1026 TERTLKTQAVNKLAEIMNRK---EPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMI 1082

Query: 1097 KIRERQRAQARPLTRYLPVRKE 1118
            K ++        +     +R E
Sbjct: 1083 KYQKELNEMQAQIAEESQIRIE 1104



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 67/277 (24%), Positives = 119/277 (42%), Gaps = 34/277 (12%)

Query: 564 ESSYLSILPKTPEGISEEQRSQE--------LAAMEETRIVILNNLEELKQKIKDINDQM 615
           E+  LS  P   E  S + R  E        L  +EE     +   EEL+QK K +N ++
Sbjct: 418 ENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRL 477

Query: 616 DESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAE 675
           +++ +EL+ E  L    + S   +L +EK +L H N +      +   +K   +  +++ 
Sbjct: 478 EKTAKELEEEITLRKSVE-SALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSL 536

Query: 676 REKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDL---------E 726
           +++LE L     +++ Q          QLQ+QL     LL  ES     L         +
Sbjct: 537 KDQLEDL-----KKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQ 591

Query: 727 FQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ-----R 781
            QQLE  +R  ++K  L +    ++ +   N+ S  E     +   + I+   Q      
Sbjct: 592 IQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGL 651

Query: 782 EQDHFVKEKNNLIMMLQREK----ENLCNLEKKYSSL 814
           E+D  +K    L+  ++ EK    E   +LEK+ S++
Sbjct: 652 EED--LKNGKILLAKVELEKRQLQERFTDLEKEKSNM 686



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 59/264 (22%), Positives = 120/264 (45%), Gaps = 31/264 (11%)

Query: 578  ISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSET 637
            +SE+Q  QE   + E ++ +     EL+++ +D + QM E   +L+ E        K++ 
Sbjct: 822  MSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAE-QYFSTLYKTQV 880

Query: 638  TELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLD-----AEREKL------ERLQELY 686
             EL +E E    L +++ + ++ +  E+     +L+     A+ E+L      E+  +L 
Sbjct: 881  RELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLE 940

Query: 687  SEQKTQLDNCPESMREQLQQQLKRDADLLDVE------SKHFEDLEFQQLEHESRLDEEK 740
             E+  +     E M    Q+  ++DA +  +E      +    +L  ++ E  ++L + +
Sbjct: 941  KEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQ 1000

Query: 741  ENLTQQLLREV------AEYQRNIVS-RKEKISALKKQAN--HIVQQAQREQDHFV---- 787
            E L++    E+      A++++ +++ R  K  A+ K A   +  +  +R  D  V    
Sbjct: 1001 EQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKE 1060

Query: 788  KEKNNLIMMLQREKENLCNLEKKY 811
            KE   L M L+ E+E L     KY
Sbjct: 1061 KENRKLHMELKSEREKLTQQMIKY 1084


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 158/761 (20%), Positives = 311/761 (40%), Gaps = 112/761 (14%)

Query: 406  QPALRERKSSISS----ISGRDDLMDYHRRQREE---RLREQEM-----ERLERQRLETI 453
            Q  + E + S+S     I    DL   H + +EE      EQE+     E  E Q     
Sbjct: 1248 QETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNE 1307

Query: 454  LSLCAEYTKPDSRLSTGTTVEDVQKINKEL-EKLQLSDEE-----------SVFEEALMS 501
            L L  E     S     TT+  ++     L EK Q S EE              +EAL  
Sbjct: 1308 LELLTE----QSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEV 1363

Query: 502  PDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKA 561
               + + H +++L  A +    S  + S +    +     +++S++ +  P  S+   + 
Sbjct: 1364 KHDQLKEHIRETL--AKIQESQSKQEQSLNM-KEKDNETTKIVSEMEQFKPKDSALL-RI 1419

Query: 562  SSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRE 621
              E   LS      + + E     +  A E+      ++L+ L++ ++  +DQ+ E+ +E
Sbjct: 1420 EIEMLGLS------KRLQESHDEMKSVAKEK------DDLQRLQEVLQSESDQLKENIKE 1467

Query: 622  LDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLE- 680
            +  +    + E K     L +++E ++ L   ++E E  I    T +K +L+A  +KL+ 
Sbjct: 1468 IVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEI---STIQK-QLEAINDKLQN 1523

Query: 681  RLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEK 740
            ++QE+Y E++ Q +    S  ++   +LK+  +    +    + +E + LE  +RL E +
Sbjct: 1524 KIQEIY-EKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQ 1582

Query: 741  ENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE 800
            E + Q +++E  E +R   + + +   LK+    IV + +  Q+   KE   L M    E
Sbjct: 1583 EEI-QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQE---KEYQFLKMTAVNE 1638

Query: 801  -KENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADA 859
             +E +C +E         K   +N   ++   I + +I        NL        + D 
Sbjct: 1639 TQEKMCEIEHLKEQFETQK---LNLENIETENIRLTQILH-----ENLEEMRSVTKERDD 1690

Query: 860  VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYL--------SDTLPR-----KKTTS 906
            + +   T +   + Q KE+ R    R  + +E L +         +T+ +      + T+
Sbjct: 1691 LRSVEET-LKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTN 1749

Query: 907  SIS------PHFSSATMGRSITPK-----AHLPLGQSNSCGSVL-------PPSLAAMAK 948
             IS       H + A   + +  +     AH+ L +       L          L+ M K
Sbjct: 1750 EISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQK 1809

Query: 949  DSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDS 1008
            D E+         Q++     Q      +  +E+   ++         KDQ   +L+L  
Sbjct: 1810 DLENSNAKLQEKIQELKANEHQLITL-KKDVNETQKKVSEMEQLKKQIKDQ---SLTLSK 1865

Query: 1009 SDSMETSISACSPDNISSAST-----SNIARIEEMERLLKQAHAEKTRLLESREREMEAK 1063
             +    +++    +N+    +      N+ R+EE  +L      E+ +L ES + E +A+
Sbjct: 1866 LEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKL------ERDQLKESLQ-ETKAR 1918

Query: 1064 KRALEEEKRRREILEKRLQEETSQ-RQKLIEKEVKIRERQR 1103
               +++E +   +L K  +E   + R+K+ EK ++I + Q+
Sbjct: 1919 DLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQK 1959



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 116/550 (21%), Positives = 228/550 (41%), Gaps = 74/550 (13%)

Query: 592  ETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLD--GEQKSETTELM---KEKEI 646
            +T+  + N LE LKQ  + IN    +   E+     + +  GE K E  + M    +K+ 
Sbjct: 961  DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD 1020

Query: 647  LDHLNRKI--AELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQL-----DNCPES 699
            L+  N +   A+++ N + E+ ++   L  E+ +L+++ E    +K QL     +N   +
Sbjct: 1021 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT 1080

Query: 700  MREQ-----LQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEY 754
            +  Q     L  +LK+  +++  E  H    E +      RL E +E L ++  +++ E 
Sbjct: 1081 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKS-QQLQEK 1139

Query: 755  QRNIVSRKEKISALKKQANHI------VQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 808
            Q+ +++ +E++S ++K+ N I      ++  +   +H   E+  L   L    E + ++ 
Sbjct: 1140 QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSIT 1199

Query: 809  KKYSSLSG-GKGFPVNPNTLKEGYISVNEINEPCGNST---------NLSPSTQFPADAD 858
            K+   L    K F    + L+ GYI   EI E  G  T         +L    +   +  
Sbjct: 1200 KERKVLKELQKSFETERDHLR-GYI--REI-EATGLQTKEELKIAHIHLKEHQETIDELR 1255

Query: 859  AVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMG 918
               +E    ++ +Q   K H +  EE    H+E     + LP  K  S      +  TM 
Sbjct: 1256 RSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEE----QELLPNVKEVSE-----TQETMN 1306

Query: 919  RSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRT 978
                 +  L   QS +  S    +LA +    E  R+      Q+  E      E  + T
Sbjct: 1307 -----ELELLTEQSTTKDST---TLARI----EMERLRLNEKFQESQE------EIKSLT 1348

Query: 979  ASESNVYL--NSFHYPDHSYKDQAFDTLSL--DSSDSMETSISACSPDNISSASTSNIAR 1034
                N+     +        K+   +TL+   +S    E S++    DN ++   S + +
Sbjct: 1349 KERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ 1408

Query: 1035 IEEMERLLKQAHAE----KTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1090
             +  +  L +   E      RL ES + EM++  +  ++ +R +E+L+    +     ++
Sbjct: 1409 FKPKDSALLRIEIEMLGLSKRLQESHD-EMKSVAKEKDDLQRLQEVLQSESDQLKENIKE 1467

Query: 1091 LIEKEVKIRE 1100
            ++ K ++  E
Sbjct: 1468 IVAKHLETEE 1477



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 136/743 (18%), Positives = 302/743 (40%), Gaps = 104/743 (13%)

Query: 432  QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQK-----------IN 480
            + E + +E  +E +E +RLE    L   Y +  S       ++++QK             
Sbjct: 1164 KNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYI 1223

Query: 481  KELEK--LQLSDEESVFEEALMS-PDTRYRCHRKDSLPDADLASCGSLSQSSASF--FTP 535
            +E+E   LQ  +E  +    L    +T     R  S   A + +   L +S        P
Sbjct: 1224 REIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIP 1283

Query: 536  RSTRNDELLSDLTRTPPPPSS-------TFPKASSESSYLSILPKTPEGISE--EQRSQE 586
                  ELL ++        +       T    + +S+ L+ +      ++E  ++  +E
Sbjct: 1284 VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEE 1343

Query: 587  LAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEI 646
            + ++ + R    +NL+ +K+ ++  +DQ+ E  RE      + + + K E +  MKEK+ 
Sbjct: 1344 IKSLTKER----DNLKTIKEALEVKHDQLKEHIRE--TLAKIQESQSKQEQSLNMKEKD- 1396

Query: 647  LDHLNRKIAELEKNIVGEKTKEKVKLDAEREKL---ERLQELYSEQKTQLDNCPESMREQ 703
             +   + ++E+E+     K K+   L  E E L   +RLQE + E K+      +  R  
Sbjct: 1397 -NETTKIVSEMEQ----FKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQR-- 1449

Query: 704  LQQQLKRDADLL-----DVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI 758
            LQ+ L+ ++D L     ++ +KH E  E  ++ H     +E+E    +L   ++E +  I
Sbjct: 1450 LQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCL--KEQEETINELRVNLSEKETEI 1507

Query: 759  VSRKEKISALKKQANHIVQQAQREQDHF-------VKEKNNLIMMLQREKE----NLCNL 807
             + ++++ A+  +  + +Q+   +++ F       V+EK N +   +  ++     L ++
Sbjct: 1508 STIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSI 1567

Query: 808  EKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATA 867
            E K   L+         N L+E    +  + +       +  + Q   D      E    
Sbjct: 1568 ESKMLELT---------NRLQESQEEIQIMIKEKEEMKRVQEALQIERDQ---LKENTKE 1615

Query: 868  VLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHL 927
            ++A   +S       +E++ Q  +   +++T  +      +   F +  +        ++
Sbjct: 1616 IVAKMKES-------QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENI 1668

Query: 928  PLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTA----SESN 983
             L Q      +L  +L  M   ++ R  LR        E  + K             +  
Sbjct: 1669 RLTQ------ILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEE 1722

Query: 984  VYLNSFHYPDHSYK-DQAFDTLSLDSSD------SMETSISACSPDNISSASTSNIARI- 1035
            + +   H  +H    D+    +S  +++       +E S  A    ++       IA + 
Sbjct: 1723 LKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMH 1782

Query: 1036 --EEMERL--LKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR---LQEETSQR 1088
              E+ E +  L+   +EKT  L + ++++E     L+E+ +  +  E +   L+++ ++ 
Sbjct: 1783 LKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNET 1842

Query: 1089 QKLIEKEVKIRERQRAQARPLTR 1111
            QK + +  +++++ + Q+  L++
Sbjct: 1843 QKKVSEMEQLKKQIKDQSLTLSK 1865



 Score = 53.9 bits (128), Expect = 9e-07
 Identities = 164/829 (19%), Positives = 308/829 (37%), Gaps = 139/829 (16%)

Query: 343  LASTSSCASDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEA--DLESLRQ 400
            + S S   S+  D  S +  NP+  LL  E+          +    ++D    D E LR 
Sbjct: 465  VCSESDVFSNTLDTLSEIEWNPATKLLNQEN-----IESELNSLRADYDNLVLDYEQLRT 519

Query: 401  ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEY 460
                 +  L+E+          +DL ++   +R+ + ++QEM+ +        L   AE 
Sbjct: 520  EKEEMELKLKEK----------NDLDEFEALERKTK-KDQEMQLIHEISNLKNLVKHAEV 568

Query: 461  TKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLA 520
               D      + VE +++   +++KLQ   +    E   M  D  Y            L 
Sbjct: 569  YNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKM--DLSY-----------SLE 615

Query: 521  SCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISE 580
            S     Q   + F   +   D                   A  ES++L       E +  
Sbjct: 616  SIEDPKQMKQTLFDAETVALD-------------------AKRESAFLR-----SENLEL 651

Query: 581  EQRSQELAA----MEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE-QKS 635
            +++ +ELA     ME    +  + LE  K+   D+  ++  +F E+    +L+DG+  K 
Sbjct: 652  KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKD 711

Query: 636  ETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKV-------KLDAEREKLERLQELYSE 688
                L  E +I D       E+E+N   E  +E+V        L +E E+L +  +  SE
Sbjct: 712  LLCNLELEGKITDLQKELNKEVEEN---EALREEVILLSELKSLPSEVERLRKEIQDKSE 768

Query: 689  QKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENL----- 743
            +   + +  + +  ++  +  R   LL+   K  +DL   Q  ++S  D+E +N      
Sbjct: 769  ELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKS-TDQEFQNFKTLHM 827

Query: 744  ------------TQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKN 791
                         +++ +E+    +        + ALK + ++  Q+ Q E+   V+E+ 
Sbjct: 828  DFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQ-EKTREVQERL 886

Query: 792  NLIMMLQREKEN----LCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNL 847
            N +  L+ + EN    L  +E++ + ++           L++    V  + +   +   L
Sbjct: 887  NEMEQLKEQLENRDSTLQTVEREKTLIT---------EKLQQTLEEVKTLTQEKDDLKQL 937

Query: 848  SPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGL---------YLSDT 898
              S Q   D            +     ++E  R+  E  KQH+E +          +S  
Sbjct: 938  QESLQIERDQ---LKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRN 994

Query: 899  LPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRG 958
            L  ++ T      F    +G  I  K  L    +         +L A  KD+E     R 
Sbjct: 995  LHMEENTGETKDEFQQKMVG--IDKKQDLEAKNTQ--------TLTADVKDNEIIEQQRK 1044

Query: 959  Y--------NHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSD 1010
                       QQM E    + E   +T  + N+ +   +  +        D L      
Sbjct: 1045 IFSLIQEKNELQQMLESVIAEKE-QLKTDLKENIEMTIENQEELRLLG---DELKKQQEI 1100

Query: 1011 SMETSISACSPDNISSASTSNIARIEE-MERLLKQAHAEKTRLLESREREMEAKKRALEE 1069
              +    A   +   S +   +A +EE ++   +Q   ++ +LL  +E   E +K+  E 
Sbjct: 1101 VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1160

Query: 1070 EKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKE 1118
            E  + E+  K L  E  + ++L E   K+ E    + + +T+   V KE
Sbjct: 1161 ENLKNELKNKELTLEHMETERL-ELAQKLNENYE-EVKSITKERKVLKE 1207



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 96/469 (20%), Positives = 195/469 (41%), Gaps = 55/469 (11%)

Query: 389  EFDEADLESLRQASGTPQPALRERKSSISSISG-RDDL------MDYHRRQREERLREQE 441
            E  + +LE++   +      L E    + S++  RDDL      +   R Q +E LRE  
Sbjct: 1654 ETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETI 1713

Query: 442  MERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMS 501
               LE+Q    I+ +  +  +       G   E   +I+   + L+ S++    ++  + 
Sbjct: 1714 TRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ 1773

Query: 502  PDTRY-RCHRKD-------------------SLPDADLASCGSLSQSSASFFTPRSTRND 541
             + R    H K+                   S    DL +  +  Q           +  
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLI 1833

Query: 542  ELLSDLTRTPPPPSSTFP-KASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVIL-- 598
             L  D+  T    S     K   +   L++     E ++  Q+  E   +EE + V+   
Sbjct: 1834 TLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHE--NLEEMKSVMKER 1891

Query: 599  NNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAE-- 656
            +NL  +++ +K   DQ+ ES +E       +  E K+      + KE +D L  KI+E  
Sbjct: 1892 DNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKT 1951

Query: 657  -----LEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRD 711
                 ++K++  +K+K++++   +  + + LQ L  ++   + +   +  EQL++Q   +
Sbjct: 1952 IQISDIQKDL--DKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQF--E 2007

Query: 712  ADLLDVESKHFEDLEFQQLEHESRLDE----EKENLTQQLLREVAEYQRN--IVSRKEKI 765
            A  L ++S   ++ +  +  HES L+E     KE    + ++E  + +R+  I + +E I
Sbjct: 2008 AQNLSMQSVRMDNFQLTKKLHES-LEEIRIVAKERDELRRIKESLKMERDQFIATLREMI 2066

Query: 766  SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 814
            +  + + NH   Q + E+      + +L   L+ +   +  L K+YS +
Sbjct: 2067 A--RDRQNH---QVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEM 2110



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 138/657 (21%), Positives = 246/657 (37%), Gaps = 141/657 (21%)

Query: 571  LPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECAL-- 628
            L K  E +S E R+Q   AME+ ++  L   ++L QK++  N++++   R L    +L  
Sbjct: 355  LKKQLEEVSLETRAQ---AMEKDQLAQLLEEKDLLQKVQ--NEKIENLTRMLVTSSSLTL 409

Query: 629  ---LDGEQKSETT------ELMKEKEILDHLN------RKIAELEKNIVGEKTKEKV-KL 672
               L  ++K   T        MK     D  N       K  +L  N++ E  +    + 
Sbjct: 410  QQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSES 469

Query: 673  DAEREKLERLQELYSEQKTQLDNCPESMREQLQ-------------QQLKRDADLLDVES 719
            D     L+ L E+     T+L N  E++  +L              +QL+ + + ++++ 
Sbjct: 470  DVFSNTLDTLSEIEWNPATKLLN-QENIESELNSLRADYDNLVLDYEQLRTEKEEMELKL 528

Query: 720  KHFEDL-EFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ 778
            K   DL EF+ LE +++ D+E      QL+ E++   +N+V   E         N  ++ 
Sbjct: 529  KEKNDLDEFEALERKTKKDQE-----MQLIHEISNL-KNLVKHAEVY-------NQDLEN 575

Query: 779  AQREQDHFVKEKNNLIMMLQR--EKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNE 836
                +   ++EK + I  LQ   + + L N++   S                    S+  
Sbjct: 576  ELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLS-------------------YSLES 616

Query: 837  INEPCGNSTNLSPSTQFPADADAVATEPATAVLASQP-QSKEHFRSLEERKKQHKEG--L 893
            I +P          T F A+  A+  +  +A L S+  + KE  + L    KQ +    L
Sbjct: 617  IEDP-----KQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQL 671

Query: 894  YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNS---CGSVLPPSLAAMAKD- 949
            Y S    +KK    +     SA     IT    L  G+      C   L   +  + K+ 
Sbjct: 672  YQSQLEAKKKMQVDLEKELQSAF--NEITKLTSLIDGKVPKDLLCNLELEGKITDLQKEL 729

Query: 950  ------------------------SESRRMLRGYN------HQQMSEGHRQKSEFYNRTA 979
                                    SE  R+ +         H   SE  +  SE  ++ +
Sbjct: 730  NKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKES 789

Query: 980  -----------SESNVYLNSFHYPDHSYKDQAFDTLSLD----------SSDSMETSISA 1018
                       ++ ++     +Y     + Q F TL +D           ++ M   I  
Sbjct: 790  RVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVN 849

Query: 1019 CSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILE 1078
             S +  +    S++  ++       Q   EKTR ++ R  EME  K  LE      + +E
Sbjct: 850  LSKE--AQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVE 907

Query: 1079 KRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDT 1135
            +     T + Q+ +E EVK   +++   + L   L + ++      H +T   NIDT
Sbjct: 908  REKTLITEKLQQTLE-EVKTLTQEKDDLKQLQESLQIERDQLKSDIH-DTVNMNIDT 962



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 76/384 (19%), Positives = 159/384 (41%), Gaps = 47/384 (12%)

Query: 440  QEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEAL 499
            QE   L+ Q LE++++   E  K D + +   T+E+        E+L+L  +E   ++ +
Sbjct: 1050 QEKNELQ-QMLESVIAE-KEQLKTDLKENIEMTIENQ-------EELRLLGDELKKQQEI 1100

Query: 500  MSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFP 559
            ++ +  +   ++  L      +C  L++             +E L + ++          
Sbjct: 1101 VAQEKNHAIKKEGELS----RTCDRLAEV------------EEKLKEKSQQLQEKQQQLL 1144

Query: 560  KASSESSYLSILPKTPEGISEEQRSQELAA--MEETRIVILNNLEELKQKIKDINDQ--- 614
                E S +       E +  E +++EL    ME  R+ +   L E  +++K I  +   
Sbjct: 1145 NVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKV 1204

Query: 615  MDESFRELDMECALLDGE-QKSETTELMKEKEI-LDHLNRK-----IAELEKNIVGEKTK 667
            + E  +  + E   L G  ++ E T L  ++E+ + H++ K     I EL ++ V EKT 
Sbjct: 1205 LKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRS-VSEKTA 1263

Query: 668  EKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEF 727
            + +      +   +LQE       + +  P        Q+   + +LL  +S   +    
Sbjct: 1264 QIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTL 1323

Query: 728  QQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ---------Q 778
             ++E E     EK   +Q+ ++ + + + N+ + KE +     Q    ++         Q
Sbjct: 1324 ARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQ 1383

Query: 779  AQREQDHFVKEKNNLIMMLQREKE 802
            +++EQ   +KEK+N    +  E E
Sbjct: 1384 SKQEQSLNMKEKDNETTKIVSEME 1407


>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
            sapiens]
          Length = 1133

 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 152/739 (20%), Positives = 297/739 (40%), Gaps = 86/739 (11%)

Query: 429  HRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQL 488
            H  Q  + ++ ++ ++      + IL  C +  KP S    G   ED       L +  L
Sbjct: 23   HSFQGPKNMKHRQQDKDSPSESDVILP-CPKAEKPHS--GNGHQAED-------LSRDDL 72

Query: 489  SDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLT 548
                S+ E  L + D      + + +   DLA    L ++   F TP+     ++L  L 
Sbjct: 73   LFLLSILEGELQARDEVIGILKAEKM---DLA----LLEAQYGFVTPK-----KVLEALQ 120

Query: 549  RTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS--QELAAMEETRIVILNNLEELKQ 606
            R      ST  +       ++ L K  E   E  R    +L   E++R   +  LEE K+
Sbjct: 121  RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180

Query: 607  KIKDINDQMDESFRELDMEC----ALLDGEQKS-ETTELMKEKEI--LDHLNRKIAELEK 659
            K K+  ++ DE    L+ EC     L+D E KS E  E  KEK +  L     K+     
Sbjct: 181  KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240

Query: 660  NIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVES 719
             +V E+ +   +L  +R+K++ L     E  T+L      ++E+ Q+  + + +L    +
Sbjct: 241  MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300

Query: 720  KHFEDLE--FQQLEHESRLDEEKENLTQQL------LREVAEYQRNIVSRKEKISALKKQ 771
            K  +D +    +L +E   D +   L Q+L      + E+ E  R++   +E++  +K++
Sbjct: 301  KFHQDQDTIMAKLTNE---DSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEK 357

Query: 772  ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS--------GGKGFPVN 823
             +   +         V+E    ++ ++ + E L  +E++   L+          K F + 
Sbjct: 358  ISK-GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLE 416

Query: 824  PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE 883
               L +  +++ ++ +    S     S +   + + + T+  +  L S     +   ++E
Sbjct: 417  VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIE 476

Query: 884  ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 943
             R +  K    L + L + KT + +       TM   +  K    L  ++S   V    +
Sbjct: 477  SRLE--KTEFTLKEDLTKLKTLTVMFVD-ERKTMSEKL-KKTEDKLQAASSQLQVEQNKV 532

Query: 944  AAMAKD--SESRRMLRGYN--HQQMSEGHRQKSEFYNRTASES----------NVYLNSF 989
              + +    E++R L+      ++M    +++ +  N+  +E           N+  N  
Sbjct: 533  TTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRL 592

Query: 990  HYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEK 1049
               +   KD   + L+ DS      S +A   +N      S    +E ++  LK   A +
Sbjct: 593  QSLEAIEKDFLKNKLNQDSG----KSTTALHQENNKIKELSQ--EVERLKLKLKDMKAIE 646

Query: 1050 TRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQ--RQKLIEKE--------VKIR 1099
              L+++ E E E  +R    E+ + + L K L+    +  + KL EK          K  
Sbjct: 647  DDLMKT-EDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRL 705

Query: 1100 ERQRAQARPLTRYLPVRKE 1118
            + + A++  L+R +   KE
Sbjct: 706  QEEEAKSGHLSREVDALKE 724


>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
            sapiens]
          Length = 1135

 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 152/739 (20%), Positives = 297/739 (40%), Gaps = 86/739 (11%)

Query: 429  HRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQL 488
            H  Q  + ++ ++ ++      + IL  C +  KP S    G   ED       L +  L
Sbjct: 23   HSFQGPKNMKHRQQDKDSPSESDVILP-CPKAEKPHS--GNGHQAED-------LSRDDL 72

Query: 489  SDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLT 548
                S+ E  L + D      + + +   DLA    L ++   F TP+     ++L  L 
Sbjct: 73   LFLLSILEGELQARDEVIGILKAEKM---DLA----LLEAQYGFVTPK-----KVLEALQ 120

Query: 549  RTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS--QELAAMEETRIVILNNLEELKQ 606
            R      ST  +       ++ L K  E   E  R    +L   E++R   +  LEE K+
Sbjct: 121  RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180

Query: 607  KIKDINDQMDESFRELDMEC----ALLDGEQKS-ETTELMKEKEI--LDHLNRKIAELEK 659
            K K+  ++ DE    L+ EC     L+D E KS E  E  KEK +  L     K+     
Sbjct: 181  KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240

Query: 660  NIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVES 719
             +V E+ +   +L  +R+K++ L     E  T+L      ++E+ Q+  + + +L    +
Sbjct: 241  MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300

Query: 720  KHFEDLE--FQQLEHESRLDEEKENLTQQL------LREVAEYQRNIVSRKEKISALKKQ 771
            K  +D +    +L +E   D +   L Q+L      + E+ E  R++   +E++  +K++
Sbjct: 301  KFHQDQDTIMAKLTNE---DSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEK 357

Query: 772  ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS--------GGKGFPVN 823
             +   +         V+E    ++ ++ + E L  +E++   L+          K F + 
Sbjct: 358  ISK-GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLE 416

Query: 824  PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE 883
               L +  +++ ++ +    S     S +   + + + T+  +  L S     +   ++E
Sbjct: 417  VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIE 476

Query: 884  ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 943
             R +  K    L + L + KT + +       TM   +  K    L  ++S   V    +
Sbjct: 477  SRLE--KTEFTLKEDLTKLKTLTVMFVD-ERKTMSEKL-KKTEDKLQAASSQLQVEQNKV 532

Query: 944  AAMAKD--SESRRMLRGYN--HQQMSEGHRQKSEFYNRTASES----------NVYLNSF 989
              + +    E++R L+      ++M    +++ +  N+  +E           N+  N  
Sbjct: 533  TTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRL 592

Query: 990  HYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEK 1049
               +   KD   + L+ DS      S +A   +N      S    +E ++  LK   A +
Sbjct: 593  QSLEAIEKDFLKNKLNQDSG----KSTTALHQENNKIKELSQ--EVERLKLKLKDMKAIE 646

Query: 1050 TRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQ--RQKLIEKE--------VKIR 1099
              L+++ E E E  +R    E+ + + L K L+    +  + KL EK          K  
Sbjct: 647  DDLMKT-EDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRL 705

Query: 1100 ERQRAQARPLTRYLPVRKE 1118
            + + A++  L+R +   KE
Sbjct: 706  QEEEAKSGHLSREVDALKE 724


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 124/604 (20%), Positives = 237/604 (39%), Gaps = 101/604 (16%)

Query: 580  EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLD---GEQKSE 636
            EE++++ LA +   + V++++LEE  +K +    +++++ R+LD E   L     E +++
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1077

Query: 637  TTEL-----MKEKE--------------------ILDHLNRKIAELEKNIVGEKTKEKVK 671
              EL      KE+E                    ++  L  +IAEL+++   EK      
Sbjct: 1078 IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137

Query: 672  LDAEREKLERLQELYSEQKTQLDN--CPESMREQLQQQLKRDADLLDVESKHFE-DLEFQ 728
               +R+  E L+ L +E +  LD     + +R + +Q++      L+ E+K+ E  ++  
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197

Query: 729  QLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQAN---HIVQQAQREQDH 785
            +  H + L+E  E L Q        ++ N+   K+ +    K+      ++QQ + E +H
Sbjct: 1198 RQRHATALEELSEQLEQ-----AKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEH 1252

Query: 786  --------------FVKEKNNLIMMLQREKENLCNLEKKYSSL-----SGGKGFPVNPNT 826
                           V E + L + L  +   L N     S+L       G  F  +  +
Sbjct: 1253 KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAAS 1312

Query: 827  LKEGYISVNE-INEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEER 885
            L+       E + E      NLS   +          E     L  Q + +E     E R
Sbjct: 1313 LESQLQDTQELLQEETRQKLNLSSRIR--------QLEEEKNSLQEQQEEEE-----EAR 1359

Query: 886  KKQHKEGLYLSDTL--PRKKTTSSISPHFSSATMGRSITPKAHL---PLGQSNSCGSVLP 940
            K   K+ L L   L   +KK    +    S     + +   A      L +       L 
Sbjct: 1360 KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLE 1419

Query: 941  PSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQA 1000
             +   + ++ +   +   +  Q  S   +++ +F    A E ++   S  Y +   +D+A
Sbjct: 1420 KTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI---SARYAEE--RDRA 1474

Query: 1001 FDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESRE--- 1057
                    +++ E    A S   ++ A    +   EE ER  KQ  A+   L+ S++   
Sbjct: 1475 -------EAEAREKETKALS---LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVG 1524

Query: 1058 ---REMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLP 1114
                E+E  KRALE++    E +  +L+E   + Q   + ++++    +A      R L 
Sbjct: 1525 KNVHELEKSKRALEQQV---EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581

Query: 1115 VRKE 1118
             R E
Sbjct: 1582 TRDE 1585



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 109/538 (20%), Positives = 214/538 (39%), Gaps = 72/538 (13%)

Query: 581  EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640
            +  ++  A  EE R  +    +EL++ + D+  +++E     +    +L  E+K     +
Sbjct: 897  QAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEE----EERNQILQNEKKKMQAHI 952

Query: 641  MKEKEILDHLN--RKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPE 698
               +E LD     R+  +LEK     K K   K++ E   LE     + ++K  +++   
Sbjct: 953  QDLEEQLDEEEGARQKLQLEKVTAEAKIK---KMEEEILLLEDQNSKFIKEKKLMEDRIA 1009

Query: 699  SMREQLQQQLKRDADLLDVESKH---FEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQ 755
                QL ++ ++  +L  + +K      DLE ++L+ E +  +E E   ++L  E  + Q
Sbjct: 1010 ECSSQLAEEEEKAKNLAKIRNKQEVMISDLE-ERLKKEEKTRQELEKAKRKLDGETTDLQ 1068

Query: 756  RNIVSRKEKISALKKQA---NHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYS 812
              I   + +I  LK Q       +Q A    D     KNN + +++  +  +  L++ + 
Sbjct: 1069 DQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFE 1128

Query: 813  SLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ 872
            S    +      N  ++    ++E  E           T+     D  A +        Q
Sbjct: 1129 SEKASR------NKAEKQKRDLSEELEAL--------KTELEDTLDTTAAQQELRTKREQ 1174

Query: 873  PQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTT-SSISPHFSSATMGRSITPKAHLPLGQ 931
             +  E  ++LEE  K H+    + D   R  T    +S     A   ++   K    L  
Sbjct: 1175 -EVAELKKALEEETKNHEA--QIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLET 1231

Query: 932  SNSCGSVLPPSLAAMAKDSESRRMLRGYN----HQQMSEGHRQKSEFYNRTASESNVYLN 987
             N   +     L  +  +SE +R          H ++SEG R + E   + +   N    
Sbjct: 1232 DNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN---- 1287

Query: 988  SFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSA--STSNIARIEEMERLLKQA 1045
                                  D++ T +       I  A  + S  +++++ + LL++ 
Sbjct: 1288 --------------------ELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEE 1327

Query: 1046 HAEKTRLLESREREMEAKKRAL----EEEKRRREILEKR---LQEETSQRQKLIEKEV 1096
              +K  L  SR R++E +K +L    EEE+  R+ LEK+   LQ + +  +K ++ ++
Sbjct: 1328 TRQKLNL-SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDL 1384



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 110/581 (18%), Positives = 223/581 (38%), Gaps = 112/581 (19%)

Query: 581  EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640
            + + +EL  ++E +  +   LEE+++K + + ++ +    +L  E  L    ++      
Sbjct: 855  QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLA 914

Query: 641  MKE---KEILDHLNRKIAELEKN---IVGEKTK------------------------EKV 670
             K+   +EIL  L  ++ E E+    +  EK K                        EKV
Sbjct: 915  AKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKV 974

Query: 671  KLDAEREKLERLQELYSEQKT-----------QLDNCPESMREQLQQQLKRDADLLDVES 719
              +A+ +K+E    L  +Q +           ++  C   + E+ +++ K  A + + + 
Sbjct: 975  TAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE-EEKAKNLAKIRNKQE 1033

Query: 720  KHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQ---ANHIV 776
                DLE ++L+ E +  +E E   ++L  E  + Q  I   + +I  LK Q       +
Sbjct: 1034 VMISDLE-ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEEL 1092

Query: 777  QQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNE 836
            Q A    D     KNN + +++  +  +  L++ + S    +      N  ++    ++E
Sbjct: 1093 QGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR------NKAEKQKRDLSE 1146

Query: 837  INEPCGNSTNLSPSTQFPADADAVAT----EPATAVLASQPQSKEHFRSLEERKKQHKEG 892
              E     T L  +    A    + T    E A    A + ++K H   +++ +++H   
Sbjct: 1147 ELEAL--KTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATA 1204

Query: 893  LYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSES 952
            L              +S     A   ++   K    L   N   +     L  +  +SE 
Sbjct: 1205 L------------EELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEH 1252

Query: 953  RRMLRGYN----HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDS 1008
            +R          H ++SEG R + E   + +   N                         
Sbjct: 1253 KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN------------------------E 1288

Query: 1009 SDSMETSISACSPDNISSA--STSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRA 1066
             D++ T +       I  A  + S  +++++ + LL++   +K   L SR R++E +K +
Sbjct: 1289 LDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLN-LSSRIRQLEEEKNS 1347

Query: 1067 LEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQAR 1107
            L+E+           QEE  + +K +EK+V   + Q A  +
Sbjct: 1348 LQEQ-----------QEEEEEARKNLEKQVLALQSQLADTK 1377



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 145/752 (19%), Positives = 275/752 (36%), Gaps = 141/752 (18%)

Query: 367  SLLAGESDRVFATRRNFSCGSVEF--DEADLESLRQASGTPQPALRERKSSISSISGRDD 424
            S L  E D V           ++F  D A LES  Q +   Q  L+E      ++S R  
Sbjct: 1283 SKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT---QELLQEETRQKLNLSSRIR 1339

Query: 425  LMDYHRRQREERLREQEMER--LERQRLETILSLCAEYTKPDSRLSTGTTVEDVQK-INK 481
             ++  +   +E+  E+E  R  LE+Q L     L     K D  L T  ++E+ +K + K
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399

Query: 482  ELEKL-QLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
            + E L Q  +E+++  + L     R +    D   D D        +  AS    +  + 
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH------QRQVASNLEKKQKKF 1453

Query: 541  DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
            D+LL++                 E S  +   +  +    E R +E  A+   R   L  
Sbjct: 1454 DQLLAE-----------------EKSISARYAEERDRAEAEAREKETKALSLARA--LEE 1494

Query: 601  LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
              E K++ +  N Q+       DME             +LM  K   D + + + ELEK+
Sbjct: 1495 ALEAKEEFERQNKQL-----RADME-------------DLMSSK---DDVGKNVHELEKS 1533

Query: 661  IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
                                 L++   E +TQL+   + ++     +L+ + ++  ++++
Sbjct: 1534 ------------------KRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQ 1575

Query: 721  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI----------VSRKEKISALKK 770
               DL+ +        DE+ E   + L+++V E +  +          V+ K+K+    K
Sbjct: 1576 FERDLQTR--------DEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLK 1627

Query: 771  QANHIVQQAQREQDHFVKEKNNLIMML---QREKENLCNLEKKYSSLSGGKGFPVNPNTL 827
                 ++ A + +D  +K+   L   +   QRE E       +  + S       +   L
Sbjct: 1628 DLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQS-----KESEKKL 1682

Query: 828  KEGYISVNEINEPCGNSTNLSPSTQFPAD--ADAVATEPA--TAVLASQPQSKEHFRSLE 883
            K     + ++ E   +S       +   D  AD +    +  +A+L  + + +     LE
Sbjct: 1683 KSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLE 1742

Query: 884  ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 943
            E  ++ +  + L +   RK T                          Q ++  + L    
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTL-------------------------QVDTLNAELAAER 1777

Query: 944  AAMAKDSESRRMLRGYNHQ---QMSEGHRQKSEFYNRTASESNVYLNSFHYP-DHSYKDQ 999
            +A  K   +R+ L   N +   ++ E        +  T S     +       +   K++
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKER 1837

Query: 1000 AFDTLSLDSSDS------METSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLL 1053
            A     +  ++       M+        D          AR+++++R L++A  E TR  
Sbjct: 1838 AAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRAN 1897

Query: 1054 ESR---EREMEAKKRALEEEKRRREILEKRLQ 1082
             SR   +RE++    A E   R    L+ RL+
Sbjct: 1898 ASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 88/446 (19%), Positives = 183/446 (41%), Gaps = 62/446 (13%)

Query: 411  ERKSSISSISGRDDLM--DYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS 468
            E+  +++ I  + ++M  D   R ++E    QE+E+ +R+       L  E T    +++
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK-------LDGETTDLQDQIA 1072

Query: 469  TGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528
                  ++Q    EL KLQL+ +E   + AL   D     H+ ++L          +++ 
Sbjct: 1073 ------ELQAQIDEL-KLQLAKKEEELQGALARGDDE-TLHKNNALKVVRELQA-QIAEL 1123

Query: 529  SASFFTPRSTRN----------DEL------LSDLTRTPPPPSSTFPKASSESSYLSIL- 571
               F + +++RN          +EL      L D   T         K   E + L    
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183

Query: 572  ---PKTPEGISEEQRSQELAAMEETRIVILN------NLEELKQKIKDINDQMDESFREL 622
                K  E   ++ R +   A+EE    +        NLE+ KQ ++  N ++    + L
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVL 1243

Query: 623  DMECALLDGEQK---SETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKL 679
                A  + ++K   ++  EL  +    D L  ++AE    +  E       L+   +K 
Sbjct: 1244 QQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKG 1303

Query: 680  ERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEE 739
             +  +  +  ++QL +  E ++E+ +Q+L   + +  +E +     E Q+ E E+R + E
Sbjct: 1304 IKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363

Query: 740  KENLTQQ---------------LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQD 784
            K+ L  Q                +  + E ++ ++   E +S   ++      + ++ ++
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN 1423

Query: 785  HFVKEKNNLIMMLQREKENLCNLEKK 810
               +E ++L + L  +++   NLEKK
Sbjct: 1424 RLQQELDDLTVDLDHQRQVASNLEKK 1449



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 146/780 (18%), Positives = 316/780 (40%), Gaps = 78/780 (10%)

Query: 391  DEADLESLRQASGTP-QPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER-Q 448
            D  D  + +Q   T  +  + E K ++   +   +      RQR     E+  E+LE+ +
Sbjct: 1157 DTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216

Query: 449  RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYR 507
            R +  L    +  + D++      V+ +Q++  E E  +   +  V E  A +S   R R
Sbjct: 1217 RFKANLEKNKQGLETDNK-ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR 1275

Query: 508  CH--RKDSLPDADLASCGSLSQSS----------ASFFTPRSTRNDELLSDLTRTPPPPS 555
                 K S    +L +  +L + +          A+    +     ELL + TR     S
Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335

Query: 556  STFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETR---------IVILNNLEELKQ 606
            S   +   E + L    +  E   +    Q LA   +           +  + +LEE K+
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395

Query: 607  KI-KD---INDQMDE---SFRELDMECALLDGEQKSETTELMKEKEILDHLNRK------ 653
            K+ KD   ++ +++E   ++ +L+     L  E    T +L  ++++  +L +K      
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455

Query: 654  -IAELEKNIVGEKTKEKVKLDAE-REK------LERLQELYSEQKTQLDNCPESMREQLQ 705
             +AE EK+I     +E+ + +AE REK      L R  E   E K + +   + +R  ++
Sbjct: 1456 LLAE-EKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514

Query: 706  QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765
              +    D+     K+  +LE  +   E +++E +  L ++L  E+   +   +  +  +
Sbjct: 1515 DLMSSKDDV----GKNVHELEKSKRALEQQVEEMRTQL-EELEDELQATEDAKLRLEVNM 1569

Query: 766  SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS--GGKGFPVN 823
             A+K Q    +Q    + +    EK  L++   RE E     E+K  +L+    K   ++
Sbjct: 1570 QAMKAQFERDLQTRDEQNE----EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID 1625

Query: 824  PNTLKEGYISVNEI-NEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSL 882
               L+    + N+  +E       L    +        A      + A   +S++  +SL
Sbjct: 1626 LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL 1685

Query: 883  EERKKQHKEGLYLSDTLPR--KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLP 940
            E    Q +E L  S+   R  ++    ++   +++  G+S        L +       L 
Sbjct: 1686 EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL------LDEKRR----LE 1735

Query: 941  PSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQA 1000
              +A + ++ E  +     N + +++  R+ +   +   +E     ++    D++ +   
Sbjct: 1736 ARIAQLEEELEEEQS----NMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLE 1791

Query: 1001 FDTLSLDSS-DSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESRERE 1059
                 L +    +E ++ +     IS A  + I ++EE      +  A   +L+   E++
Sbjct: 1792 RQNKELKAKLQELEGAVKSKFKATIS-ALEAKIGQLEEQLEQEAKERAAANKLVRRTEKK 1850

Query: 1060 MEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKED 1119
            ++     +E+E+R  +  ++++ E+ + R K ++++++  E +  +A    R L    +D
Sbjct: 1851 LKEIFMQVEDERRHADQYKEQM-EKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909



 Score = 30.8 bits (68), Expect = 8.5
 Identities = 22/83 (26%), Positives = 43/83 (51%), Gaps = 11/83 (13%)

Query: 1056 REREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQR------AQARPL 1109
            +E E++AK   L + K ++  +E  L+E   + Q+L+E++  + E+ +      A+A  +
Sbjct: 850  QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909

Query: 1110 TRYLPVRKEDF-----DLRSHVE 1127
               L  +K++      DL S VE
Sbjct: 910  RARLAAKKQELEEILHDLESRVE 932


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 128/605 (21%), Positives = 259/605 (42%), Gaps = 94/605 (15%)

Query: 581  EQRSQELAAMEETRIVILNNLEELKQKIKDINDQM-DESFRELDMECALLDGEQKSETTE 639
            +Q    + A +  ++ +LN LEE K+K++D+  ++ +ES  + D+E A +   +KS   E
Sbjct: 411  DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATV--SEKSRIME 468

Query: 640  LMKE-----KEILD------------------HLNRKIAELEKNIVGEKTKEKVKLDAER 676
            L K+     +E+ +                   L ++I+ L++ +   +T  + ++ + +
Sbjct: 469  LEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK 528

Query: 677  EKLERLQELYSEQ-------KTQLDNCPESMREQLQQQLKRDADLLDV-ESKHFEDLEFQ 728
            E     +E + ++         +L    ES++ +L+   K ++D++ + +SK    LE  
Sbjct: 529  EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSK----LETA 584

Query: 729  QLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDH--- 785
               H+  ++E K + ++ L  E AE+       K +I  ++    H ++  Q +QD    
Sbjct: 585  IASHQQAMEELKVSFSKGLGTETAEF----AELKTQIEKMRLDYQHEIENLQNQQDSERA 640

Query: 786  -FVKEKNNL---IMMLQREKENLCNLEKKYSSLSGGKG-----FPVNPNTLKEGYISVNE 836
               KE   L   +M + +EKEN  +LE   S L   +           N L+E  I V E
Sbjct: 641  AHAKEMEALRAKLMKVIKEKEN--SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE 698

Query: 837  ---INEPCGNSTNL--SPSTQFPADADAVATEPATAVLASQPQS--KEHFRSLEERKKQH 889
               +   C   T +  + ++Q  A  + +    A    +S+ +S  K+  + LE  +KQ 
Sbjct: 699  LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQI 758

Query: 890  KEGLYLSDTLPRKKTTSSISPHFSSATMGRSI-TPKAHLPLGQSNSCGSVLPPSLAAM-- 946
            K           K   SS +   +    GR +        L + +     L   L  +  
Sbjct: 759  KH------LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE 812

Query: 947  --AKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSY--KDQAFD 1002
              A+ SE    ++    + +++ H QK E +N  +S+      +    +  +  KD+  +
Sbjct: 813  KFAEASEEAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREE 871

Query: 1003 TLSLDSSDSMETSIS---ACSPDNISSASTSN------IARIEEMERLLKQAHAEKTRLL 1053
             L + + + +E  I+     S DN S  +  N         +EE++  L +A+   + L 
Sbjct: 872  QL-IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQ 930

Query: 1054 ESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIE------KEVKIRERQRAQAR 1107
            +S E      +++ +E  ++ E  +K L+ + S  +K +E      +E+K R  +RA + 
Sbjct: 931  KSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR-YERATSE 989

Query: 1108 PLTRY 1112
              T++
Sbjct: 990  TKTKH 994



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 124/583 (21%), Positives = 222/583 (38%), Gaps = 87/583 (14%)

Query: 261  RATENQLTPL-SLPPRNSLGNSKRTKL------GEKDLPHSVIDNDNYLNFSSLSSGALP 313
            +ATE +L  L +L   +S G S+  KL       EK + H  I+     N  S  + ++ 
Sbjct: 721  KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK----NAESSKASSI- 775

Query: 314  YKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGES 373
              T   +G     + L    S     K  L        + F +AS    +   S+     
Sbjct: 776  --TRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE-TV 832

Query: 374  DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERK-----------------SSI 416
            +++      F+  S     +DLE LR+     +   RE+                  + I
Sbjct: 833  NKLHQKEEQFNMLS-----SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEI 887

Query: 417  SSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDV 476
              +SG D+     +   E RL+E+++E L+            + TK +         E+ 
Sbjct: 888  MKMSG-DNSSQLTKMNDELRLKERDVEELQ-----------LKLTKAN---------ENA 926

Query: 477  QKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASF 532
              + K +E + +  E+S  E A    + +    RK S  +  + +    C  L       
Sbjct: 927  SFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERA 986

Query: 533  FTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEE 592
             +   T+++E+L +L +T          A  E+S   +L +  E   +  +++     E+
Sbjct: 987  TSETKTKHEEILQNLQKTLLDTEDKLKGAREENS--GLLQELEELRKQADKAKAAQTAED 1044

Query: 593  TRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNR 652
               ++    +E  + +  + D    + + L  E   L         EL K KE+L   N+
Sbjct: 1045 AMQIMEQMTKEKTETLASLEDTKQTNAK-LQNELDTLKENNLKNVEELNKSKELLTVENQ 1103

Query: 653  KIAELEKNI------VGEKTKEKVKLDAEREKL-ERL----QELYSEQKTQLDNCPESMR 701
            K+ E  K I        +K+++   L  E  KL E L     E+ S QK  L+     + 
Sbjct: 1104 KMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQK--LEEERSVLN 1161

Query: 702  EQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSR 761
             QL +  KR++  +    +    L+ + +   S L  EK+   ++L  EV       V R
Sbjct: 1162 NQLLEMKKRESKFIKDADEEKASLQ-KSISITSALLTEKDAELEKLRNEVT------VLR 1214

Query: 762  KEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENL 804
             E  SA  K  + +VQ  + ++     +  NL + L+  K  L
Sbjct: 1215 GENASA--KSLHSVVQTLESDKVKLELKVKNLELQLKENKRQL 1255



 Score = 53.9 bits (128), Expect = 9e-07
 Identities = 90/455 (19%), Positives = 188/455 (41%), Gaps = 80/455 (17%)

Query: 409  LRERKSSISSISGR-DDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRL 467
            ++E+++S+ +I  + D   D H  + E+ L + +   ++ + LE + + C E TK     
Sbjct: 657  IKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK----- 711

Query: 468  STGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASC----- 522
                       I+    +L+ ++E+ +  +AL    +  +   K      + A       
Sbjct: 712  ----------VIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL 761

Query: 523  ---GSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYL--SILPKTPEG 577
                +   S AS  T      +  L++L       S        E   L       + E 
Sbjct: 762  EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEA 821

Query: 578  ISEEQRSQE----LAAMEETRIVILNNLEELKQKIKDINDQMDESFRELD---------- 623
            +S ++  QE    L   EE   ++ ++LE+L++ + D    M+  FRE D          
Sbjct: 822  VSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD----MEAKFREKDEREEQLIKAK 877

Query: 624  -------MECALLDGEQKSETTEL-----MKEKEILDHLNRKIAELEKNI-VGEKTKEKV 670
                    E   + G+  S+ T++     +KE+++ + L  K+ +  +N    +K+ E +
Sbjct: 878  EKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV-EELQLKLTKANENASFLQKSIEDM 936

Query: 671  KLDAEREKLERLQELYSEQKTQLDNCPESMREQLQ------QQLKR--DADLLDVESKHF 722
             + AE+ + E  ++ + E+K +L+     + ++++      Q+LK   +    + ++KH 
Sbjct: 937  TVKAEQSQQEAAKK-HEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHE 995

Query: 723  EDLEFQQ---LEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQA 779
            E L+  Q   L+ E +L   +E     LL+E+ E ++          A K +A    + A
Sbjct: 996  EILQNLQKTLLDTEDKLKGAREE-NSGLLQELEELRK---------QADKAKAAQTAEDA 1045

Query: 780  QREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 814
             +  +   KEK   +  L+  K+    L+ +  +L
Sbjct: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1080



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 116/587 (19%), Positives = 225/587 (38%), Gaps = 85/587 (14%)

Query: 577  GISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDE--SFRELDMECALLDGEQK 634
            G  EE   +E+ A+      +    E LK K++  N +  +  +  +  +E A+   +Q 
Sbjct: 532  GAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQA 591

Query: 635  SETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLD 694
             E  ++   K  L     + AEL+  I      EK++LD + E +E LQ     ++    
Sbjct: 592  MEELKVSFSKG-LGTETAEFAELKTQI------EKMRLDYQHE-IENLQNQQDSERAAHA 643

Query: 695  NCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL-EHESRLDEEKE------------ 741
               E++R +L + +K   + L+      +  E Q L E E  L++ +E            
Sbjct: 644  KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 703

Query: 742  -----------NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ---AQREQDHFV 787
                       N T QL +   E   ++ + ++  S  K +   + QQ   A+++  H  
Sbjct: 704  AKCNEQTKVIDNFTSQL-KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE 762

Query: 788  KEKN-------NLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
             EKN       ++   LQ  +  L NL++  S +S      V     KE  I   +  E 
Sbjct: 763  IEKNAESSKASSITRELQGRELKLTNLQENLSEVS-----QVKETLEKELQILKEKFAEA 817

Query: 841  CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEH-------FRSLEERKKQ---HK 890
               + ++  S Q   +      E    + +   + +E+       FR  +ER++Q    K
Sbjct: 818  SEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAK 877

Query: 891  EGLY--LSDTLPRKKTTSS-ISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMA 947
            E L   +++ +      SS ++       +      +  L L ++N   S L  S+  M 
Sbjct: 878  EKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMT 937

Query: 948  KDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLD 1007
              +E        + Q+ ++ H ++ +   R  S+    + + H      K + ++  + +
Sbjct: 938  VKAEQ-------SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR-YERATSE 989

Query: 1008 SSDSMETSISAC------SPDNISSASTSNIARIEEMERLLKQAHAEKT--------RLL 1053
            +    E  +         + D +  A   N   ++E+E L KQA   K         +++
Sbjct: 990  TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIM 1049

Query: 1054 ESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRE 1100
            E   +E      +LE+ K+    L+  L        K +E+  K +E
Sbjct: 1050 EQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKE 1096



 Score = 35.4 bits (80), Expect = 0.34
 Identities = 61/280 (21%), Positives = 118/280 (42%), Gaps = 29/280 (10%)

Query: 534 TPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTP---EGISEEQR--SQELA 588
           +P ++    + S  +     PS T     + S Y   +  T    E + E+Q+   Q LA
Sbjct: 310 SPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLA 369

Query: 589 AMEETRIVIL---NNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
             +  R  +    +++ E++Q++    D  D+   EL+ +   L    ++   E ++   
Sbjct: 370 ERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLN 429

Query: 646 ILDHLNRKIAELEKNIVGEK-TKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQL 704
            L+   RK+ +L+  +  E  TK  +++    EK  R+ EL  +   ++    E     L
Sbjct: 430 QLEEEKRKVEDLQFRVEEESITKGDLEVATVSEK-SRIMELEKDLALRVQEVAE-----L 483

Query: 705 QQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEK 764
           +++L+ +    DV      D+    L+  S L +EK  +T+       ++QR I S KE 
Sbjct: 484 RRRLESNKPAGDV------DMSLSLLQEISSL-QEKLEVTR------TDHQREITSLKEH 530

Query: 765 ISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQR-EKEN 803
             A ++     ++      +   KE  +L   L+   KEN
Sbjct: 531 FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKEN 570



 Score = 34.3 bits (77), Expect = 0.77
 Identities = 27/104 (25%), Positives = 52/104 (50%), Gaps = 24/104 (23%)

Query: 1028 STSNIARIEEMERLLKQAHAEKTRLLESR-----------EREMEAKKRALEEEKRRREI 1076
            +TS++  IE+   L +  H +    LE++           +RE       LEEEKR+ E 
Sbjct: 381  ATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVED 440

Query: 1077 LEKRLQEET-----------SQRQKL--IEKEVKIRERQRAQAR 1107
            L+ R++EE+           S++ ++  +EK++ +R ++ A+ R
Sbjct: 441  LQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELR 484


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 151/727 (20%), Positives = 292/727 (40%), Gaps = 92/727 (12%)

Query: 137  ERALRLSE-KPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISR 195
            E+A+R+ + +   S+Y  R   HD  +    +E  K    +L +   + L D      +R
Sbjct: 317  EKAVRVDKLESEVSRYKER--LHDIEFYKARVEELKEDNQVL-LETKTMLEDQLEGTRAR 373

Query: 196  SGAASMPSSPKQARKMSIQDSLALQPKLTRHK--ELASENINLR-TRKYSSSSLSHMGAY 252
            S             K  + D + ++  + R K  EL  EN+ L   +K S     H+G  
Sbjct: 374  SDKLHELEKENLQLKAKLHD-MEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGW- 431

Query: 253  SRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGAL 312
               L ++ R +E     LS  P+ SLG+        + L   + +         L +   
Sbjct: 432  --ELEQISRTSE-----LSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484

Query: 313  PYKTSASE------GNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV------ 360
              + +AS+       N  +S  + +  +  V  K  L +  + + D   + + +      
Sbjct: 485  SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544

Query: 361  ---GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS 417
                +     +L  E++ +  T  +    S    EA ++ + + +     +++E  S +S
Sbjct: 545  LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604

Query: 418  SISG-----RDDLMDYHRRQREERLREQEMERLER-----QRLETILSLCAEYTKPDSRL 467
             I       + +L  Y  +       E E+  LE+     Q+  T L +  E  +   + 
Sbjct: 605  KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664

Query: 468  STGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYRCHRKDSLPDADLASCGSLS 526
            ++     ++++ N++L+K   S +   F+ E+L   +++      +   + +   C S+ 
Sbjct: 665  NS-----ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK 719

Query: 527  QSSASFFTPRSTRNDELLSD---LTRTPPPPSSTFPKASS-ESSYLSI------LPKTPE 576
             +           N EL S+   L +      ++F K    E SY  +      L KT E
Sbjct: 720  MAQLQL------ENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE 773

Query: 577  GISE--EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQK 634
              ++  +Q   EL  +E     +  NLEELK   K + +Q+++  + L+ E + L+ ++K
Sbjct: 774  NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL-EQLEKENKSLEQETSQLEKDKK 832

Query: 635  S---ETTELMKEKEI----LDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYS 687
                E   L ++ EI    L+  N KI  LEK     KT  K ++   +E   RL+EL  
Sbjct: 833  QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE---NKTLSK-EIGIYKESCVRLKELEK 888

Query: 688  EQKTQLDNCP------ESMREQL------QQQLKRDADLLDVESKHFEDLEFQQLEHESR 735
            E K  +           ++RE L       QQ+  D + L  E +    L  ++L H+ +
Sbjct: 889  ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI-GLNKERLLHDEQ 947

Query: 736  LDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIM 795
              +++  L +  L    +  +++  ++EKI+AL+ +        Q+ +      K N   
Sbjct: 948  STDDRYKLLESKLESTLK--KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1005

Query: 796  MLQREKE 802
            + QR+ E
Sbjct: 1006 LKQRQDE 1012



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 92/453 (20%), Positives = 176/453 (38%), Gaps = 54/453 (11%)

Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREER--LREQEMERLERQR 449
           +A +  LRQ        L + K  +  +      ++  R Q+E    L +    R+ R  
Sbjct: 257 KAKIRRLRQELEEKTEQLLDCKQELEQME-----IELKRLQQENMNLLSDARSARMYRDE 311

Query: 450 LETILSLCAEYTKPDSRLST-GTTVEDVQKINKELEKLQLSDEESVFEEALMSPD----T 504
           L+ +        K +S +S     + D++     +E+L+  D + + E   M  D    T
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK-EDNQVLLETKTMLEDQLEGT 370

Query: 505 RYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKAS-- 562
           R R  +   L   +L     L          R    + +  ++T       S        
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430

Query: 563 ------SESSYLSILPKTPEGIS-EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQM 615
                 S +S LS  P+   G    E  S  L  +E     +   +EEL+  +  +    
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA 490

Query: 616 DESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAE 675
            +  + ++ E   L  + +    E+++EK+ L +       L K+++ EK + +  ++  
Sbjct: 491 SKILK-MEKENQRLSKKVEILENEIVQEKQSLQNCQN----LSKDLMKEKAQLEKTIETL 545

Query: 676 REKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVE-------------SKHF 722
           RE  ER  ++  ++   L+    S+R+  + Q+  +A + D+E             S   
Sbjct: 546 RENSERQIKILEQENEHLNQTVSSLRQ--RSQISAEARVKDIEKENKILHESIKETSSKL 603

Query: 723 EDLEFQ------QLEH---ESRLDEEKENLTQQLLREVAEYQRNIVSRK---EKISALKK 770
             +EF+      +LEH   +    EE EN    L +E    Q+ I + K   EKI AL++
Sbjct: 604 SKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663

Query: 771 QANHIVQQAQREQDHFVKEKNNLIMMLQREKEN 803
           + + + ++ ++ +      KN    +   EKEN
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKEN 696



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 116/567 (20%), Positives = 226/567 (39%), Gaps = 56/567 (9%)

Query: 586  ELAAMEETRIVILNNLEELKQKIKDINDQM-DESFRELDMECALLDGEQKSETTELMKEK 644
            EL A+ E  +     +++L+ ++    +++ D  F +  +E    D +   ET  +++++
Sbjct: 311  ELDALREKAV----RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 366

Query: 645  -EILDHLNRKIAELEKNIVGEKTK---EKVKLDAEREKLERLQELYSEQKTQLDNCPESM 700
             E     + K+ ELEK  +  K K    +++ D +R+K+E L E   E  T      +SM
Sbjct: 367  LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME---ENMTLEMAQKQSM 423

Query: 701  REQLQ-----QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQ 755
             E L      +Q+ R ++L +   K     E  +L     L  E EN  Q L + V E +
Sbjct: 424  DESLHLGWELEQISRTSELSEAPQKSLGH-EVNELTSSRLLKLEMEN--QSLTKTVEELR 480

Query: 756  RNIVS---RKEKISALKKQANHIVQQAQREQDHFVKEKN------NLIMMLQREKENLCN 806
              + S      KI  ++K+   + ++ +  ++  V+EK       NL   L +EK     
Sbjct: 481  TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK---AQ 537

Query: 807  LEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPAT 866
            LEK   +L          N+ ++  I   E        ++L   +Q  A+A     E   
Sbjct: 538  LEKTIETL--------RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589

Query: 867  AVL-ASQPQSKEHFRSLEERKKQHKEGL-YLSDTLPRKKTTSSISPHFSSAT--MGRSIT 922
             +L  S  ++      +E  K+Q K+ L +  +   R +   +   H       + + IT
Sbjct: 590  KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKIT 649

Query: 923  PKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASES 982
                       +C  +          + E+R++ +  +  +      +  E  N    E 
Sbjct: 650  -------NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE 702

Query: 983  NVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLL 1042
            N+ L   +             L L++ +             +  AS     R+E   + L
Sbjct: 703  NLELRR-NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL 761

Query: 1043 KQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQE--ETSQRQKLIEKEVKIRE 1100
               +    + LE+  ++++  +  L++ +   + L+K L+E   +S+R + +EKE K  E
Sbjct: 762  DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLE 821

Query: 1101 RQRAQARPLTRYLPVRKEDFDLRSHVE 1127
            ++ +Q     + L   KE+  LR   E
Sbjct: 822  QETSQLEKDKKQL--EKENKRLRQQAE 846



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 86/418 (20%), Positives = 180/418 (43%), Gaps = 80/418 (19%)

Query: 432 QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINK---------- 481
           +R+ ++ EQE E L     +T+ SL     +  S++S    V+D++K NK          
Sbjct: 550 ERQIKILEQENEHLN----QTVSSL-----RQRSQISAEARVKDIEKENKILHESIKETS 600

Query: 482 ------ELEKLQLSDEESVFEE----ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSAS 531
                 E EK Q+  E   ++E    A    +  +   +++ L    + +     +   +
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660

Query: 532 FFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQ-------RS 584
                    ++  S+L R       T     + +  L  L K    + EE         S
Sbjct: 661 L--------EQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712

Query: 585 QELAAMEETRIVILNN-LEELKQKIKD----------INDQMDESFRELDMECALLDGEQ 633
            + A+M+  ++ + N  LE  K+++K             ++++ S++ LD+E   L    
Sbjct: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772

Query: 634 KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAER-EKLERLQELYSEQKTQ 692
           ++   ++ + +  L  L  +   L+KN+      E++K+ ++R E+LE+  +   ++ +Q
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNL------EELKISSKRLEQLEKENKSLEQETSQ 826

Query: 693 LDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDE-EKENLTQQLLREV 751
           L    E  ++QL+++ KR     +++    E       E+  ++   EKEN T  L +E+
Sbjct: 827 L----EKDKKQLEKENKRLRQQAEIKDTTLE-------ENNVKIGNLEKENKT--LSKEI 873

Query: 752 AEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEK 809
             Y+ + V  KE    L+K+   +V++A  +    V  + +L+    + ++   +LEK
Sbjct: 874 GIYKESCVRLKE----LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 95/470 (20%), Positives = 192/470 (40%), Gaps = 46/470 (9%)

Query: 372  ESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRR 431
            E+ R+  T  N S   ++  E++L+ L   + T Q  L E K S   +          + 
Sbjct: 764  ENQRLQKTLEN-SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE---------QL 813

Query: 432  QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKI-NKELEKLQLSD 490
            ++E +  EQE  +LE+ + +  L    +  +  + +   T  E+  KI N E E   LS 
Sbjct: 814  EKENKSLEQETSQLEKDKKQ--LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871

Query: 491  EESVFEEALMSPDTRYRCHRKDSLPDA--DLASCGSLSQSSASFFTPRSTRNDEL---LS 545
            E  +++E+ +      +   K+ +  A  D+ +  +L +   S        N++L     
Sbjct: 872  EIGIYKESCVRLKELEK-ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930

Query: 546  DLTRTPPPPSSTFPKASSESSYLSILPKTPEGI---SEEQRSQELAAMEETRIVILNNLE 602
            +L +             S      +L    E     S E + +++AA+E       N  +
Sbjct: 931  ELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 990

Query: 603  ELKQKIKDIN------------DQMDESFRELDMECALLDGEQKSETTELMKEKEILDHL 650
            +L+Q++K +             ++M +S   +  E    + E +  T EL+K K+ L  +
Sbjct: 991  QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1050

Query: 651  NRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKR 710
             R  A L+      KT+ K +L+ +   L+        Q   L     +++ Q   +L+ 
Sbjct: 1051 ERNNATLQAEKQALKTQLK-QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ-NAKLQV 1108

Query: 711  DADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISAL-K 769
            +   L+ +S    +   Q L  +S L+ E E++ ++   ++     +++   EK+  L +
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE-REDLKSLYDSLIKDHEKLELLHE 1167

Query: 770  KQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKG 819
            +QA+        E +  + +   L    +  +    +LE +Y+ L   KG
Sbjct: 1168 RQAS--------EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKG 1209



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 44/193 (22%), Positives = 94/193 (48%), Gaps = 17/193 (8%)

Query: 585  QELAAMEETRIVILN-NLEELKQKIKDI---NDQMDESFRELDMECALLDGEQKSETTEL 640
            +++  +E+ ++++ N N E +  + K +   ND+++ ++ +L  E  +L  + K+     
Sbjct: 1215 EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNL---- 1270

Query: 641  MKEKEILDHLNRKIAELEKNIVGEKTKEKVK-LDAEREKLERLQELYSEQKTQLDNCPES 699
               K +L+  N K+ +        K KE+ + LD    KL    EL S+ K  L+     
Sbjct: 1271 ---KSLLN--NSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1325

Query: 700  MREQLQQQLKRDADLLD--VESKHFEDLEFQQ-LEHESRLDEEKENLTQQLLREVAEYQR 756
            + +Q+Q  + ++  LL+  +ESK    +E +Q ++  + L  +KE L ++++ +   Y  
Sbjct: 1326 LLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDP 1385

Query: 757  NIVSRKEKISALK 769
            +   R+     LK
Sbjct: 1386 SPPRRRGNWITLK 1398



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 43/224 (19%), Positives = 103/224 (45%), Gaps = 30/224 (13%)

Query: 605  KQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGE 664
            ++ +K + D + +   +L+    LL   Q SE   L+ +   L   ++ + E+E   + +
Sbjct: 1145 REDLKSLYDSLIKDHEKLE----LLHERQASEYESLISKHGTLKSAHKNL-EVEHRDLED 1199

Query: 665  KTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFED 724
            +  + +K   + E LE++ ++  E+    +   E++  + ++    +  L    S+  ++
Sbjct: 1200 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1259

Query: 725  LEFQQLEHE--------SRLDEEKENLTQQLLREVAEYQR-NIVSRK-----EKISALK- 769
             E  Q +H+        S+L++ +       L+E  +YQ+ +I S K     E +S LK 
Sbjct: 1260 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE--QYQQLDITSTKLNNQCELLSQLKG 1317

Query: 770  ---KQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810
               ++  H++ Q Q      +  +N  ++    E ++L ++E++
Sbjct: 1318 NLEEENRHLLDQIQT-----LMLQNRTLLEQNMESKDLFHVEQR 1356


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 102/459 (22%), Positives = 194/459 (42%), Gaps = 88/459 (19%)

Query: 411  ERKSSISSISGRDDLM--DYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS 468
            E+  S++ +  + + M  D   R R E  + QE+E+  R++LE                 
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKT-RRKLE------------GDSTD 1059

Query: 469  TGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528
                + ++Q    EL K+QL+ +E   + AL   +              +L S   +S+ 
Sbjct: 1060 LSDQIAELQAQIAEL-KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES--QISEL 1116

Query: 529  SASFFTPRSTRN-------------DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTP 575
                 + R++RN             + L ++L  T    ++     S     ++IL KT 
Sbjct: 1117 QEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTL 1176

Query: 576  EGISEEQRSQELAAMEETRIVILNNLEELKQKI---KDINDQMDESFRELDMECALLDGE 632
            E   EE ++ E A ++E R      +EEL +++   K +   ++++ + L+ E     GE
Sbjct: 1177 E---EEAKTHE-AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE----RGE 1228

Query: 633  QKSETTELMKEKEILDHLNRKI-AELEKNIV----GEK---------TKEKVKLD----- 673
              +E   L++ K   +H  +K+ A+L++  V    GE+         TK +V+LD     
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL 1288

Query: 674  --AEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLE 731
                  K  +L + +S  ++QL +  E ++E+ +Q+L     L  VE +     E  QLE
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE--QLE 1346

Query: 732  HESRLDEEKENLTQQL--------------------LREVAEYQRNIVSRKEKISALKKQ 771
             E   +E K NL +Q+                    L    E +R +    E +S   ++
Sbjct: 1347 EE---EEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEE 1403

Query: 772  ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810
                  + ++ +    +E ++L++ L  ++++ CNLEKK
Sbjct: 1404 KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK 1442



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 102/477 (21%), Positives = 195/477 (40%), Gaps = 47/477 (9%)

Query: 394  DLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMER--LERQRLE 451
            D  +L       Q  L+E      S+S +   ++  +    E+L E+E  +  LE+Q + 
Sbjct: 1302 DFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQ-IA 1360

Query: 452  TILSLCAEYTKP--DSRLSTGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYRC 508
            T+ +  A+  K   DS     T  E  +K+ K+LE L    EE V   + L    TR + 
Sbjct: 1361 TLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ 1420

Query: 509  HRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYL 568
               D L D D        + SA     +  + D+LL++        +    +A +E+   
Sbjct: 1421 ELDDLLVDLDH------QRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474

Query: 569  SILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECAL 628
                 +     EE   Q+ A +E         +E+L        D + +S  EL+     
Sbjct: 1475 ETKALSLARALEEAMEQK-AELERLNKQFRTEMEDLMSS----KDDVGKSVHELEKSKRA 1529

Query: 629  LDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSE 688
            L+ + +   T+L + ++ L         LE N+   K + +  L    E+ E  ++    
Sbjct: 1530 LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVR 1589

Query: 689  QKTQLDNCPESMREQ----LQQQLKRDADLLDVES-------------KHFEDLEFQQLE 731
            Q  +++   E  R+Q    +  + K + DL D+E+             K    L+ Q  +
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649

Query: 732  HESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQ---ANHIVQQAQREQDHFVK 788
                LD+ + +  +++L +  E ++ + S + ++  L+++   A    +QAQ+E+D    
Sbjct: 1650 CMRELDDTRAS-REEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELAD 1708

Query: 789  E------KNNLIMMLQREKE-NLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEIN 838
            E      K  L +  +R  E  +  LE++     G     +N + LK+  + +++IN
Sbjct: 1709 EIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTEL-IN-DRLKKANLQIDQIN 1763



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 122/643 (18%), Positives = 252/643 (39%), Gaps = 107/643 (16%)

Query: 580  EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTE 639
            EE++S+ LA ++     ++ +LEE  ++ +    +++++ R+L+ +   L  +      +
Sbjct: 1011 EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ 1070

Query: 640  LMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPES 699
            + + K  L     ++      +  E  ++ + L   RE   ++ EL  ++  + +    +
Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL--QEDLESERASRN 1128

Query: 700  MREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIV 759
              E+ ++ L  + + L  E +   D    Q E  S+ ++E   L + L  E   ++  I 
Sbjct: 1129 KAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188

Query: 760  SRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKG 819
              ++K S   ++    ++Q +R + +  K K      L+ E+  L N   +   L  GKG
Sbjct: 1189 EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT----LENERGELAN---EVKVLLQGKG 1241

Query: 820  FPVNPNTLKEGYISVNEI--NEPCGNSTNLSPS-TQFPADADAVATEPATAVLASQPQSK 876
               +     E  +   ++  NE     T L+   T+   + D V        L SQ  SK
Sbjct: 1242 DSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTG------LLSQSDSK 1295

Query: 877  -----EHFRSLEER--------KKQHKEGLYLSDTLPR-KKTTSSISPHFSSATMGRSIT 922
                 + F +LE +        ++++++ L LS  L + +   +S           +   
Sbjct: 1296 SSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355

Query: 923  PKAHLPL-GQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN----- 976
             K    L  Q       +  S+  +    E +R L+  + + +S+ H +K   Y+     
Sbjct: 1356 EKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ-KDLEGLSQRHEEKVAAYDKLEKT 1414

Query: 977  --RTASESNVYLNSFHYPDHS-----YKDQAFDTLSLD---------------SSDSMET 1014
              R   E +  L    +   S      K + FD L  +                +++ E 
Sbjct: 1415 KTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474

Query: 1015 SISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESRE------REMEAKKRALE 1068
               A S   ++ A    + +  E+ERL KQ   E   L+ S++       E+E  KRALE
Sbjct: 1475 ETKALS---LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531

Query: 1069 EE----KRRREILEKRLQ----------------------------EETSQRQKLI---- 1092
            ++    K + E LE  LQ                            E++ +++K +    
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQV 1591

Query: 1093 -EKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNID 1134
             E E ++ + ++ ++  +     +  +  DL +H+++A  N D
Sbjct: 1592 REMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD 1634



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 94/454 (20%), Positives = 191/454 (42%), Gaps = 42/454 (9%)

Query: 388  VEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMER--L 445
            VE +E   + L+      Q  ++E +  +         +   +   E +L++ E E+  L
Sbjct: 924  VEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIIL 983

Query: 446  ERQRLETILSLCAEYTKPDSRLSTGTT-VEDVQKINKELEKLQLSDEESV--FEEALMSP 502
            E Q  +    L  E    + R++  TT + + ++ +K L KL+   E  +   EE L   
Sbjct: 984  EDQNCK----LAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039

Query: 503  DTRY----RCHRKDSLPDADLAS-CGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSST 557
            + +     +  RK      DL+     L    A      + + +EL + L R     +  
Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQK 1099

Query: 558  FPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDIND---- 613
                       S + +  E +  E+ S+  A  E+ +  +   LE LK +++D  D    
Sbjct: 1100 NMALKKIRELESQISELQEDLESERASRNKA--EKQKRDLGEELEALKTELEDTLDSTAA 1157

Query: 614  -QMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKE-KVK 671
             Q   S RE ++       E++++T E   ++    H ++ + EL + +  E+TK  K  
Sbjct: 1158 QQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH-SQAVEELAEQL--EQTKRVKAN 1214

Query: 672  LDAEREKLERLQ-ELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL 730
            L+  ++ LE  + EL +E K  L    +S  E  +++++     L V+    E +  +  
Sbjct: 1215 LEKAKQTLENERGELANEVKVLLQGKGDS--EHKRKKVEAQLQELQVKFNEGERVRTELA 1272

Query: 731  EHESRLDEEKENLT----------QQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
            +  ++L  E +N+T           +L ++ +  +  +   +E +    +Q   +  + +
Sbjct: 1273 DKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK 1332

Query: 781  REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 814
            + +D    EKN+    L+ E+E   NLEK+ ++L
Sbjct: 1333 QVED----EKNSFREQLEEEEEAKHNLEKQIATL 1362



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 87/403 (21%), Positives = 163/403 (40%), Gaps = 50/403 (12%)

Query: 392  EADLESLRQASGTPQPALRERKSSIS-SISGRDDLMDYHRRQREERLREQEMERLERQRL 450
            E +L++   A    +  L+  K+     + GRD+  +  ++Q   ++RE E E LE +R 
Sbjct: 1545 EDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAE-LEDERK 1603

Query: 451  ETILSLCA----EYTKPDSRLSTGTTVEDVQKINKELEKLQ---------LSDEESVFEE 497
            +  +++ A    E    D      +  ++  +  K+L KLQ         L D  +  EE
Sbjct: 1604 QRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREE 1663

Query: 498  ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSST 557
             L          +K    +A++        ++           DEL  ++  +    S  
Sbjct: 1664 ILAQAKEN---EKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANS----SGK 1716

Query: 558  FPKASSESSYLSI-LPKTPEGISEEQRSQEL-------AAMEETRIVILNNLEELK-QKI 608
               A  E   L   + +  E + EEQ + EL       A ++  +I    NLE    QK 
Sbjct: 1717 GALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKN 1776

Query: 609  KDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKE 668
            ++   Q++   +EL ++   ++G  KS      K K  +  L  KIA+LE+ +  E TKE
Sbjct: 1777 ENARQQLERQNKELKVKLQEMEGTVKS------KYKASITALEAKIAQLEEQLDNE-TKE 1829

Query: 669  KVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQ 728
            +    A  +++ R ++   +   Q+D+       +  +Q K  AD      K  +    +
Sbjct: 1830 R---QAACKQVRRTEKKLKDVLLQVDD-----ERRNAEQYKDQADKASTRLKQLK----R 1877

Query: 729  QLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQ 771
            QLE      +      ++L RE+ +      +   ++S+LK +
Sbjct: 1878 QLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 108/554 (19%), Positives = 220/554 (39%), Gaps = 71/554 (12%)

Query: 582  QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELM 641
            Q   EL A  E    +   L   KQ++++I   ++    E +  C  L  E+K     + 
Sbjct: 890  QAETELCAEAEE---LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946

Query: 642  KEKEILDHLN--RKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPES 699
            + +E L+     R+  +LEK     K K   KL+ E+  LE      +++K  L++    
Sbjct: 947  ELEEQLEEEESARQKLQLEKVTTEAKLK---KLEEEQIILEDQNCKLAKEKKLLEDRIAE 1003

Query: 700  MREQLQQQLKRDADLLDVESKH---FEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQR 756
                L ++ ++   L  +++KH     DLE ++L  E +  +E E   ++L  +  +   
Sbjct: 1004 FTTNLTEEEEKSKSLAKLKNKHEAMITDLE-ERLRREEKQRQELEKTRRKLEGDSTDLSD 1062

Query: 757  NIVSRKEKISALKKQ---ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSS 813
             I   + +I+ LK Q       +Q A    +    +KN  +  ++  +  +  L++   S
Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLES 1122

Query: 814  LSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAV----L 869
                +      N  ++    + E  E     T L  +    A    + ++    V     
Sbjct: 1123 ERASR------NKAEKQKRDLGEELEAL--KTELEDTLDSTAAQQELRSKREQEVNILKK 1174

Query: 870  ASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPL 929
              + ++K H   ++E +++H +   + +   + + T  +  +   A        K  L  
Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQA--VEELAEQLEQTKRVKANLEKA--------KQTLEN 1224

Query: 930  GQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQM----SEGHRQKSEFYNRTASESNVY 985
             +      V    L     DSE +R       Q++    +EG R ++E  ++  ++  V 
Sbjct: 1225 ERGELANEV--KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADK-VTKLQVE 1281

Query: 986  LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1045
            L++              T  L  SDS  + ++     + S+      +++++ + LL++ 
Sbjct: 1282 LDNV-------------TGLLSQSDSKSSKLT----KDFSALE----SQLQDTQELLQEE 1320

Query: 1046 HAEKTRL---LESREREMEAKKRALEEEKRRREILEKR---LQEETSQRQKLIEKEVKIR 1099
            + +K  L   L+  E E  + +  LEEE+  +  LEK+   L  + +  +K +E  V   
Sbjct: 1321 NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCL 1380

Query: 1100 ERQRAQARPLTRYL 1113
            E      R L + L
Sbjct: 1381 ETAEEVKRKLQKDL 1394



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 25/109 (22%), Positives = 53/109 (48%), Gaps = 9/109 (8%)

Query: 1037 EMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEV 1096
            ++ R  ++  A++  L++ RE+++ A+ R  E      E L+ +L  E  Q Q+ ++ E 
Sbjct: 839  QVSRQEEEMMAKEEELVKVREKQLAAENRLTE-----METLQSQLMAEKLQLQEQLQAET 893

Query: 1097 KI-RERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEK 1144
            ++  E +  +AR   +   + +   DL + VE      + C H+   +K
Sbjct: 894  ELCAEAEELRARLTAKKQELEEICHDLEARVE---EEEERCQHLQAEKK 939


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 135/713 (18%), Positives = 274/713 (38%), Gaps = 93/713 (13%)

Query: 406  QPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEY----T 461
            Q + R  K   S+    DDL+    RQ EE++ +       ++RL+T  S   +Y    T
Sbjct: 918  QSSQRTGKGQPSNKEDVDDLVS-QLRQTEEQVNDL------KERLKTSTSNVEQYQAMVT 970

Query: 462  KPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS 521
              +  L+    V +  + N E+   + ++ ++  E+ LM  +       K  L D    +
Sbjct: 971  SLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKE-----KQELQDDKRRA 1025

Query: 522  CGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEE 581
              S+ Q  +      S+  +E+   L R     S+       + +      +    +  +
Sbjct: 1026 IESMEQQLSELKKTLSSVQNEVQEALQRASTALSN------EQQARRDCQEQAKIAVEAQ 1079

Query: 582  QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELM 641
             + +    +    +  L   +E   K+  +   ++E+ ++ + +  LL+ +   E  E M
Sbjct: 1080 NKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ--LLECKASWEERERM 1137

Query: 642  KEKEI------LDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDN 695
             + E+       + L ++   L   I  EK  +KV    +      L    SE+    + 
Sbjct: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQI--EKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQ 1195

Query: 696  CPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQ 755
              E +R      ++R+ ++ +     FE  + + L +  R++         L RE+ E Q
Sbjct: 1196 ILEILRF-----IRREKEIAETR---FEVAQVESLRYRQRVE--------LLERELQELQ 1239

Query: 756  RNIVSRKEKISALKK-QANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 814
             ++ + +EK+    K  A H     + E  + V E N    ML+ EKE L   E+    +
Sbjct: 1240 DSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNK---MLREEKERL---EQDLQQM 1293

Query: 815  SGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ-- 872
                        L+   + + E N      + +  + +   + D    +     L SQ  
Sbjct: 1294 QA------KVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQK 1347

Query: 873  -PQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQ 931
             P ++E+ + L E++   K    L++ + R K  + I+   +S T  +++       L +
Sbjct: 1348 DPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLK--AEIARSNASLTNNQNLIQSLKEDLNK 1405

Query: 932  SNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHY 991
              +    +   L A   D + +        Q    G R K+++    A +          
Sbjct: 1406 VRTEKETIQKDLDAKIIDIQEKVKTIT---QVKKIGRRYKTQYEELKAQQ---------- 1452

Query: 992  PDHSYKDQAFDTLSLDSSDSMETSISACS----PDNISSASTSNIARIEEMERLLKQAHA 1047
                  D+  +T +  S D  E  +S        + ++ A T + +   ++E L K    
Sbjct: 1453 ------DKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSE 1506

Query: 1048 EKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRE 1100
            ++T     +E+ ++ +     E  R R+ L+ R  +E   RQ++ EKE K R+
Sbjct: 1507 KETEARNLQEQTVQLQS----ELSRLRQDLQDRTTQEEQLRQQITEKEEKTRK 1555



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 109/562 (19%), Positives = 221/562 (39%), Gaps = 88/562 (15%)

Query: 395  LESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETIL 454
            L  L +A G     +R+ + S + IS   +++  H        R  E  + + QRL   L
Sbjct: 504  LMELEEARGNH--VIRDEEVSSADISSSSEVISQHLVS----YRNIEELQQQNQRLLVAL 557

Query: 455  SLCAEYTKPDSRLSTGTTVEDVQ-KINK---ELEKLQLSDEESV-FEEALMSPDTRYRCH 509
                E  + + + +T + + ++Q K+     ELE+L+ S +  +   ++++     YR  
Sbjct: 558  RELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRIL 617

Query: 510  RKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP-PSSTFPKASSESSYL 568
               +   A      SL   S +  TP+     + +S    TP P P     +A    + L
Sbjct: 618  LSQTTGVAIPLHASSLDDVSLAS-TPKRPSTSQTVS----TPAPVPVIESTEAIEAKAAL 672

Query: 569  SILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDM---- 624
              L +  E   +E+   E    E+        LE+L++++ D+  Q  +   +LD     
Sbjct: 673  KQLQEIFENYKKEKAENEKIQNEQ--------LEKLQEQVTDLRSQNTKISTQLDFASKR 724

Query: 625  -------------ECALLDGEQKSETTELMKEKEILDHL-------NRKIAELE---KNI 661
                         E   L    +  T    K+++I++ +       N K+A  E   +N+
Sbjct: 725  YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784

Query: 662  VGEKTKEK---VKLDAEREKL---ERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLL 715
              EK   K   V+L  +RE L   +R Q L       +    E    + +Q+L    + L
Sbjct: 785  KKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKL 844

Query: 716  DVESKHFE---------------DLEFQ------QLEHESRLDEEKENLTQQLLREVAEY 754
            + E  H +               +L+ Q      QL+ E+ L    + L +   +E+A  
Sbjct: 845  EHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATL 904

Query: 755  QRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNL-EKKYSS 813
            ++++ + + ++++   Q     Q + +E      + ++L+  L++ +E + +L E+  +S
Sbjct: 905  KQHLSNMEVQVASQSSQRTGKGQPSNKE------DVDDLVSQLRQTEEQVNDLKERLKTS 958

Query: 814  LSGGKGFPVNPNTLKEGYISVNEINEPCGNS--TNLSPSTQFPADADAVATEPATAVLAS 871
             S  + +     +L+E      ++ E    +    L  S +F    +    E        
Sbjct: 959  TSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQEL 1018

Query: 872  QPQSKEHFRSLEERKKQHKEGL 893
            Q   +    S+E++  + K+ L
Sbjct: 1019 QDDKRRAIESMEQQLSELKKTL 1040



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 75/415 (18%), Positives = 183/415 (44%), Gaps = 38/415 (9%)

Query: 397  SLRQASGTPQPA-LRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRL-ETIL 454
            S  Q   TP P  + E   +I + +    L +     ++E+   ++++  + ++L E + 
Sbjct: 646  STSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVT 705

Query: 455  SLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 514
             L ++ TK  ++L   +   ++ + N E  + +++   S+ E       T  +  +  + 
Sbjct: 706  DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREIT---SLHERNQKLTATTQKQEQIINT 762

Query: 515  PDADLASCGSLSQSSASFFTPRSTRNDELLSDLT--RTPPPPSSTFPKASSESSYLSILP 572
               DL   G+  + + +     + + ++ +  L+  R      S   +   ++  L+ L 
Sbjct: 763  MTQDLR--GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL- 819

Query: 573  KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 632
            +T +GI E   ++    +      + + +  LK+K+++  +Q     R LD++      +
Sbjct: 820  QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQ 879

Query: 633  QKSETTELMKEKEILDHLNRKIAELEKNI------VGEKTKEKV-------KLDAE---- 675
              +ET   +  KE+L +  ++IA L++++      V  ++ ++        K D +    
Sbjct: 880  LDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVS 939

Query: 676  --REKLERLQELYSEQKTQLDNCP--ESMREQLQQQLKRDADLLD-----VESKHFEDLE 726
              R+  E++ +L    KT   N    ++M   L++ L ++  + +     +E +  E  E
Sbjct: 940  QLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAE 999

Query: 727  FQ-QLEHE-SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQA 779
            FQ QLE +   +++EK+ L     R +   ++ +   K+ +S+++ +    +Q+A
Sbjct: 1000 FQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRA 1054



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 145/712 (20%), Positives = 266/712 (37%), Gaps = 110/712 (15%)

Query: 430  RRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLS 489
            +RQREE  R Q+       +LE  +       +   + +  ++V  +++ N+ +E +Q+ 
Sbjct: 438  KRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSV--LERDNRRME-IQVK 494

Query: 490  DEESVFEEALMSPDTRYRCH--RKDSLPDADLASCGS-LSQSSASFFTPRSTRNDELLSD 546
            D        LM  +     H  R + +  AD++S    +SQ   S+      RN E L  
Sbjct: 495  DLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSY------RNIEELQQ 548

Query: 547  LTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQ 606
                                 L  L +  E    E++    + + E ++ + + L EL+Q
Sbjct: 549  ----------------QNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQ 592

Query: 607  KIKDINDQM---DESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVG 663
              K    QM   D   R+ DM   LL     S+TT +          +  +A   K    
Sbjct: 593  LRKSRQHQMQLVDSIVRQRDMYRILL-----SQTTGVAIPLHASSLDDVSLASTPKRPST 647

Query: 664  EKTK---------EKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADL 714
             +T          E  +    +  L++LQE++   K +     +   EQL++  ++  DL
Sbjct: 648  SQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDL 707

Query: 715  LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVS---RKEKISALKKQ 771
                +K    L+F    +E   D             V  Y+R I S   R +K++A  ++
Sbjct: 708  RSQNTKISTQLDFASKRYEMLQD------------NVEGYRREITSLHERNQKLTATTQK 755

Query: 772  ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGY 831
               I+    ++    ++  N  + + +   ENL   EK+   LS      V  +  +E  
Sbjct: 756  QEQIINTMTQD----LRGANEKLAVAEVRAENL-KKEKEMLKLS-----EVRLSQQRESL 805

Query: 832  ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKE 891
            ++     E  G +  L+         +   TE     L+SQ +  EH   +   KK+ + 
Sbjct: 806  LA-----EQRGQNLLLTNLQTIQGILERSETETKQR-LSSQIEKLEH--EISHLKKKLEN 857

Query: 892  GLYLSDTLPR----------KKTTSSISPHFSSATMGRS-----ITPKAHLPLGQSNSCG 936
             +    TL R          ++  +  + H ++  + ++      T K HL    SN   
Sbjct: 858  EVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHL----SNMEV 913

Query: 937  SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNR-TASESNVYLNSFHYPDHS 995
             V   S     K   S +        Q+ +   Q ++   R   S SNV           
Sbjct: 914  QVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNV----------- 962

Query: 996  YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLES 1055
             + QA  T SL+ S + E  ++     NI      +     ++E+ L +   EK  L + 
Sbjct: 963  EQYQAMVT-SLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDD 1021

Query: 1056 REREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQAR 1107
            + R +E+ ++ L E K+    ++  +QE   +    +  E + R   + QA+
Sbjct: 1022 KRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK 1073



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 50/230 (21%), Positives = 94/230 (40%), Gaps = 48/230 (20%)

Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELM 641
           ++++EL   ++  I I +     K++++     +  +   L  E   L  + K    +L 
Sbjct: 94  EKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLK 153

Query: 642 KEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMR 701
           +       L  K+ EL+ + V  K +EK        +LE+ +EL   Q T L+       
Sbjct: 154 ESNTTKGELQLKLDELQASDVSVKYREK--------RLEQEKELLHSQNTWLNT------ 199

Query: 702 EQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSR 761
                +LK   D L                    L  EK N       E+ E + N+ ++
Sbjct: 200 -----ELKTKTDEL------------------LALGREKGN-------EILELKCNLENK 229

Query: 762 KEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKY 811
           KE++S L++Q N +    +   +H  K   +L+  L+  KE   ++E+K+
Sbjct: 230 KEEVSRLEEQMNGL----KTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF 275



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 46/201 (22%), Positives = 90/201 (44%), Gaps = 17/201 (8%)

Query: 578  ISEEQRSQELAAMEETRIVILNNLEELKQKIKDIND----QMDESFRELDMECALLDGEQ 633
            + E Q  +E     ET+   L +  E  QK     +     + E   +L  E + L  + 
Sbjct: 1473 VQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDL 1532

Query: 634  KSETTELMKEKEILDHLNRKIAELEKNIVGEKTK------EKVKLDAEREKLERLQELYS 687
            +  TT+   E+++   +  K  +  K IV  K+K       K +L  E E+L++      
Sbjct: 1533 QDRTTQ---EEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALD 1589

Query: 688  EQKTQLDNCPESMREQLQQQLKR-DADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQ 746
            +QK +LD    +++ Q + ++ R + +L + + +H E  +  Q E  +++ E++  +T  
Sbjct: 1590 QQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQ-EPSNKVPEQQRQIT-- 1646

Query: 747  LLREVAEYQRNIVSRKEKISA 767
            L    A  +R I S  +  +A
Sbjct: 1647 LKTTPASGERGIASTSDPPTA 1667



 Score = 37.4 bits (85), Expect = 0.091
 Identities = 87/416 (20%), Positives = 155/416 (37%), Gaps = 77/416 (18%)

Query: 689  QKTQLDNCPESMREQLQQQLKRDADLLD-VESKHFE---DLEFQQLEHESRLDEEKENLT 744
            ++T+L+  P+S++ +L++ L      +D ++ +H +   + E Q  E E RL   +E L 
Sbjct: 10   ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69

Query: 745  QQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE---QDHFVKEKNNLIMMLQREK 801
             +  RE    +  +     ++ AL ++   +     R    Q  F + K      L+ EK
Sbjct: 70   NE-TRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEE----LEAEK 124

Query: 802  ENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVA 861
             +L    ++ S              L+     V  +NE    S       Q   D     
Sbjct: 125  RDLIRTNERLS------------QELEYLTEDVKRLNEKLKESNTTKGELQLKLD----- 167

Query: 862  TEPATAVLASQPQSKEHFRSLEERKK-QHKEGLYLSDTLPRKKTTSSISPHFSSATMGRS 920
                  + AS    K   + LE+ K+  H +  +L+  L  K  T  +            
Sbjct: 168  -----ELQASDVSVKYREKRLEQEKELLHSQNTWLNTEL--KTKTDEL------------ 208

Query: 921  ITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKS-EFYNRTA 979
                  L LG+      +L        K  E  R+    N  + S  H QK  E      
Sbjct: 209  ------LALGREKG-NEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKL 261

Query: 980  SESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIAR-IEEM 1038
             E+     S     H+          L++   +     + + D  S A ++ + R +EE+
Sbjct: 262  KEAKEQQASMEEKFHN---------ELNAHIKLSNLYKSAADD--SEAKSNELTRAVEEL 310

Query: 1039 ERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK--RLQEETSQRQKLI 1092
             +LLK+A  E  + ++    E+E  K  +E     +E+LEK  RL++E      L+
Sbjct: 311  HKLLKEA-GEANKAIQDHLLEVEQSKDQME-----KEMLEKIGRLEKELENANDLL 360



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 89/445 (20%), Positives = 173/445 (38%), Gaps = 56/445 (12%)

Query: 409 LRERKSSISSISGRDDLMDYHRRQR----EERLREQEMERLERQRLETILSLCAEYTKPD 464
           L +++S I  + GR +       Q+    E+RL   + ERL  +  E   SL  E  K +
Sbjct: 29  LADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQ-ERLVNETREC-QSLRLELEKLN 86

Query: 465 SRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGS 524
           ++L   T      + NKELE   ++ + ++   A+ S  TR +   +      DL     
Sbjct: 87  NQLKALT------EKNKELE---IAQDRNI---AIQSQFTRTK--EELEAEKRDLIRTNE 132

Query: 525 LSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS 584
                  + T    R +E L +   T         +  +    +    K  E   E   S
Sbjct: 133 RLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHS 192

Query: 585 Q-------------ELAAMEETR----IVILNNLEELKQKIKDINDQMD-----ESFREL 622
           Q             EL A+   +    + +  NLE  K+++  + +QM+         + 
Sbjct: 193 QNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQK 252

Query: 623 DMECALLDGEQKSETTELMKEK---EILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKL 679
            +E  L   ++  E    M+EK   E+  H+  K++ L K+   +   +  +L    E+L
Sbjct: 253 HVEDLLTKLKEAKEQQASMEEKFHNELNAHI--KLSNLYKSAADDSEAKSNELTRAVEEL 310

Query: 680 ERLQELYSEQKTQLDNC---PESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRL 736
            +L +   E    + +     E  ++Q+++++      L+ E ++  DL        + L
Sbjct: 311 HKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAIL 370

Query: 737 DEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIV------QQAQREQDHFVKEK 790
            EE+          VA+  +  +   E  +A  +  + ++      ++  +  D  VKE 
Sbjct: 371 SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV 430

Query: 791 NNLIMMLQREKENLCNLEKKYSSLS 815
                +L+R++E     +K  +SLS
Sbjct: 431 EAKAPILKRQREEYERAQKAVASLS 455



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 57/318 (17%), Positives = 120/318 (37%), Gaps = 30/318 (9%)

Query: 410  RERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLST 469
            + R   + S     D  +Y +   E+ +  + +++L     E I  L AE  + ++ L+ 
Sbjct: 1336 KARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLT----EEIGRLKAEIARSNASLTN 1391

Query: 470  GTTV-----EDVQKINKELEKLQLSDEESVFE--------EALMSPDTRYRCH------R 510
               +     ED+ K+  E E +Q   +  + +          +     RY+        +
Sbjct: 1392 NQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQ 1451

Query: 511  KDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSI 570
            +D + +    S G   +   S          EL   L +      S   +  +    LS 
Sbjct: 1452 QDKVMETSAQSSGDHQEQHVSV-----QEMQELKETLNQAETKSKSLESQVENLQKTLSE 1506

Query: 571  LPKTPEGISEE--QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECAL 628
                   + E+  Q   EL+ + +         E+L+Q+I +  ++  ++      + A 
Sbjct: 1507 KETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAH 1566

Query: 629  LDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSE 688
            L G +   T E  + K+    L+++  EL+  I   K++ + ++     +L   QE + E
Sbjct: 1567 LAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLE 1626

Query: 689  QKTQLDNCPESMREQLQQ 706
            Q+ +       + EQ +Q
Sbjct: 1627 QRDEPQEPSNKVPEQQRQ 1644



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 27/107 (25%), Positives = 48/107 (44%), Gaps = 7/107 (6%)

Query: 1010 DSMETSISACSPDN--ISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRAL 1067
            + +   + A +  N  +  A   NIA   +  R  ++  AEK  L+ + ER  +  +   
Sbjct: 83   EKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLT 142

Query: 1068 EEEKRRREILEKRLQEETSQRQKLIEKE-----VKIRERQRAQARPL 1109
            E+ KR  E L++    +   + KL E +     VK RE++  Q + L
Sbjct: 143  EDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKEL 189


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 124/702 (17%), Positives = 289/702 (41%), Gaps = 127/702 (18%)

Query: 475  DVQKINKELEKLQLS------DEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528
            +++++N+ELE+++++       +   FE A+   D                   G ++Q 
Sbjct: 170  EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRD-------------------GIITQL 210

Query: 529  SASFFTPRSTRNDELLSDLTRTPPPP-----------SSTFPKASSESSYLSILPKTPEG 577
            +A+    R  +++ +   L  T               S T   ++  S+   +L    + 
Sbjct: 211  TANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQI 270

Query: 578  ISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSET 637
            ++ +Q+ +E   +          LE+ ++K +D   Q+  SF +  ++   ++ ++K E 
Sbjct: 271  LTHQQQLEEQDHL----------LEDYQKKKEDFTMQI--SFLQEKIKVYEMEQDKKVEN 318

Query: 638  T---ELMKEKEILDHLNRKIAELEKNIVGEKTK----EKVKLDAEREKLERLQELYSEQK 690
            +   E+ +++ I++ LN KI E EK  +  K K    +K+  + + + +++ QE+    K
Sbjct: 319  SNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEI-KNMK 377

Query: 691  TQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLRE 750
             +L N  +  R+  ++  +    + +++ ++ +D +F+  +   R+++E +   +QL  E
Sbjct: 378  LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET-DIVQRMEQETQRKLEQLRAE 436

Query: 751  VAE-YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEK 809
            + E Y + IV  K+++        H+ Q  +               M  R K  + N  +
Sbjct: 437  LDEMYGQQIVQMKQELIR-----QHMAQMEE---------------MKTRHKGEMENALR 476

Query: 810  KYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVL 869
             YS+++      VN + +K   +++NE+N    ++   S   +   +   +  E      
Sbjct: 477  SYSNIT------VNEDQIKLMNVAINELNIKLQDTN--SQKEKLKEELGLILEEKCALQR 528

Query: 870  ASQPQSKEHFRSLEE----RKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKA 925
              +   +E   S E+    R+   ++   L++      T   +     SA+  R      
Sbjct: 529  QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588

Query: 926  H----------LPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFY 975
            H          L + +     +VL     +   + E  R    ++H++     ++  E  
Sbjct: 589  HEAEVTNYKIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647

Query: 976  NRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTS---NI 1032
            +R   E        HY       Q  D L  + S  +ET       DN+ +        I
Sbjct: 648  HRINIEKLKDNLGIHYK------QQIDGLQNEMSQKIETM--QFEKDNLITKQNQLILEI 699

Query: 1033 ARIEEMERLLKQAHAEKTRL-----------LESREREMEAKKRALEEEKRRREILEKRL 1081
            ++++++++ L  + +E+  L           L   E+E    ++ ++E + + E+LEK++
Sbjct: 700  SKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQM 759

Query: 1082 QE-ETSQRQKLIEKEVK---IRERQRAQARPLTRYLPVRKED 1119
            +E E   ++K  + E +   +++ ++     L  + PV +E+
Sbjct: 760  KEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEE 801



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 136/702 (19%), Positives = 275/702 (39%), Gaps = 90/702 (12%)

Query: 422  RDDLMDYHRRQREERLREQEMER-------LERQRLETILSLCAEYTKPDSRLSTGTTVE 474
            RDDL      Q++ +  E ++E        LE+++   ++ L  +    + +L       
Sbjct: 2016 RDDL------QKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069

Query: 475  DVQKINKELEKLQLSDEESVFEEAL-----MSPDTRYRCHRKDSLPD---ADLASCGSLS 526
            D Q I++E E+     E    E+ L       P + ++    + L +        C  L 
Sbjct: 2070 DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129

Query: 527  QSSASFFTPRSTRNDEL------LSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISE 580
             S          RN+E+      + +L +     + TF K      + ++  K PE   E
Sbjct: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK-PELSLE 2188

Query: 581  EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640
             Q   E  A++     I  NLEE  ++ ++  +  +E  ++L M+  +    QK E+T  
Sbjct: 2189 VQLQAERDAIDRKEKEI-TNLEEQLEQFREELENKNEEVQQLHMQLEI----QKKESTTR 2243

Query: 641  MKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESM 700
            ++E E  + L +   ++EK  +  K  + +    +     +  ++  E++ ++D   E +
Sbjct: 2244 LQELEQENKLFKD--DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV 2301

Query: 701  REQLQQQLKRDADLLDVESKH--FEDLEFQ---QLEHESRLDEEKENLTQQLLREVAEYQ 755
             + LQQQLK   D   +E K+    DLE Q    +  +  +   +E   +QL   + + Q
Sbjct: 2302 TK-LQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQ 2360

Query: 756  RNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS 815
            + + +  +K S      +      + + D  + EK  L   ++   E +  ++      +
Sbjct: 2361 QELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETN 2420

Query: 816  GGKGFPVNPNT-----LKEGYISVNEINEPCGNSTNLSPS--TQFPADADAVATEPATAV 868
                F +N  T     LK    SV +I     NS N++    ++   + + V TE A   
Sbjct: 2421 ----FKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKS 2476

Query: 869  LASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLP 928
            L    +++ +F+S     +++ +G  ++      +  S++S      T            
Sbjct: 2477 L----ENQTYFKSF----EENGKGSIINLETRLLQLESTVSAKDLELTQ----------- 2517

Query: 929  LGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNS 988
                               KD + +        Q+     ++  E     A  S + L +
Sbjct: 2518 --------------CYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEA 2563

Query: 989  FHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAE 1048
                +++   Q   T+S +   +   +++    D + S  ++   RI E+E  + + H  
Sbjct: 2564 VQ--EYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMH-- 2619

Query: 1049 KTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1090
             T L+  +E+   A+K  LE+EK+  E+ +     E  QR+K
Sbjct: 2620 -TSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK 2660



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 65/275 (23%), Positives = 126/275 (45%), Gaps = 46/275 (16%)

Query: 581  EQRSQELAAMEETRIVILNNLEELK---QKIKDINDQMDESFRELDMECALLDGEQKSET 637
            ++++  +  +E+  +   N L+EL+   Q+I++  + +      +  E   ++ +   ET
Sbjct: 1939 QEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQET 1998

Query: 638  TELMKEK--------EILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQ 689
             +LMKEK        ++ D L +++  LE ++  + ++    ++ E+EK   L +L  +Q
Sbjct: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRF---IELEQEKNTELMDL-RQQ 2054

Query: 690  KTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL----------EHESRLDE- 738
               L+   E MR+ L +Q        DV  +  + LE QQL          EH++R  E 
Sbjct: 2055 NQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE-QQLKVVPRFQPISEHQTREVEQ 2113

Query: 739  ------EKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ---------QAQREQ 783
                  EK +   +LL    + QR+I  R E+I  L+ +   + Q         Q   ++
Sbjct: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDR 2173

Query: 784  DHF----VKEKNNLIMMLQREKENLCNLEKKYSSL 814
             HF     K + +L + LQ E++ +   EK+ ++L
Sbjct: 2174 KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNL 2208



 Score = 53.9 bits (128), Expect = 9e-07
 Identities = 122/606 (20%), Positives = 237/606 (39%), Gaps = 111/606 (18%)

Query: 394  DLESLRQAS--GTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 451
            +LE+L+Q S  G  +     R SS  + +G ++  +      E+  +E+E++R       
Sbjct: 1659 ELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVE----EQTFKEKELDRKPEDVPP 1714

Query: 452  TILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRK 511
             ILS        + R +       + KI  E+ K   + EE++    L   D   +    
Sbjct: 1715 EILS--------NERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSS 1766

Query: 512  DSL-----PDADLASCGS------LSQSSASFFTPRSTRND------------ELLSDLT 548
             SL      +A + SC          +S  S+      RND            EL   L 
Sbjct: 1767 ASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLV 1826

Query: 549  R-----TPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIV------- 596
            R     T   P +     +  S   + + K  E ISE     E A + +T ++       
Sbjct: 1827 RSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQK 1886

Query: 597  -----ILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETT---ELMKEKEILD 648
                  L   EEL++++ + +   ++   EL     ++DG    +T    ++ ++ +I+D
Sbjct: 1887 QEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIID 1946

Query: 649  HLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYS------------------EQK 690
             L +++     N + E   E+ ++  ERE L R +E                     ++K
Sbjct: 1947 RLEQELL-CASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEK 2005

Query: 691  TQLDNCPESMREQLQQQLK-----------RDADLLDVESKHFEDLEFQQLEHESRLDEE 739
             ++    E +R+ LQ+Q+K           R  +L   ++    DL  Q    E +L++ 
Sbjct: 2006 LEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKM 2065

Query: 740  KENLTQQLL-----REV-------AEYQRNIVSRKEKIS-----ALKKQANHIVQQAQRE 782
            ++ L +Q +     R+V        E Q  +V R + IS      +++ ANH+ ++  + 
Sbjct: 2066 RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKC 2125

Query: 783  QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 842
             +  +  K  L   +Q   E +  LE +   L   +   V+ +T ++  +   +      
Sbjct: 2126 SE-LLLSKEQLQRDIQERNEEIEKLEFRVRELE--QALLVSADTFQK--VEDRKHFGAVE 2180

Query: 843  NSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRK 902
                LS   Q  A+ DA+  +     + +  +  E FR   E K +  + L++   + +K
Sbjct: 2181 AKPELSLEVQLQAERDAI--DRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK 2238

Query: 903  KTTSSI 908
            ++T+ +
Sbjct: 2239 ESTTRL 2244



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 101/498 (20%), Positives = 202/498 (40%), Gaps = 95/498 (19%)

Query: 390  FDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLER 447
            + + +  S++Q S   +P L ERK+ I++IS   DL+   + QRE  + +  Q  E    
Sbjct: 2965 YSDGEDHSIQQVS---EPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSD 3021

Query: 448  QRLETILSLCAEYTKPDSRL---------STGTT-------------VEDVQKINKELEK 485
             R E +L+L   + +  S L         + GTT              E   +    +E 
Sbjct: 3022 WRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMEC 3081

Query: 486  LQLSDEESVFEE------ALMSPDTRYRCHRKDSLPDADLASCGSLSQSS--------AS 531
            LQ +D  S+  E       +       +  ++   P  +L       + S         S
Sbjct: 3082 LQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3141

Query: 532  FFTPRSTRND-----------ELLSDLTRTPPPPSSTFPKASS-----ESSYLSILPKTP 575
                R+T              EL S+L +T     +T           E+  L +  KT 
Sbjct: 3142 SMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTD 3201

Query: 576  EG-------ISEEQRSQELA-AMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECA 627
            E         SE+++S+EL  A+E+ +  +  + E  K++++D+   + ES ++ +++  
Sbjct: 3202 EVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSL-ESQKQRNLQLN 3260

Query: 628  LL---------DGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVK-----LD 673
            LL         + +QK E+  ++ + ++ +   R    LE  ++ E  K +++     LD
Sbjct: 3261 LLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGR---NLELQVLLESEKVRIREMSSTLD 3317

Query: 674  AEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHE 733
             ERE   +LQ      +++     E + ++LQ+QL         E KH   +E      +
Sbjct: 3318 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL---------EEKHSRIVELLNETEK 3368

Query: 734  SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNL 793
             +LD  +   T+Q + +  +  R  +  +++ +   ++  H +Q    +    ++EK   
Sbjct: 3369 YKLDSLQ---TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425

Query: 794  IMMLQREKENLCNLEKKY 811
            +  L  E + L  + +++
Sbjct: 3426 VYKLDLEGQRLQGIMQEF 3443



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 80/453 (17%), Positives = 196/453 (43%), Gaps = 51/453 (11%)

Query: 388 VEFDEADLESLRQASGTPQPALRERKSSISSISG-RDDLMDYHRRQREERLREQ------ 440
           + F    ++  RQ     +  L E   S+S++   + +++     ++E  L+ +      
Sbjct: 537 LSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNY 596

Query: 441 --EMERLERQRLETILSLCAEYTKPD-SRLSTGTTVEDVQKINKELEKLQLSDEESVFEE 497
             ++E LE+++   +L   AE  + +  RL T       ++++K  E L++    ++ E+
Sbjct: 597 KIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINI-EK 654

Query: 498 ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSST 557
              +    Y+  + D L +       ++     +  T    + ++L+ ++++      S 
Sbjct: 655 LKDNLGIHYK-QQIDGLQNEMSQKIETMQFEKDNLIT----KQNQLILEISKLKDLQQSL 709

Query: 558 FPKASSESSY-LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMD 616
               S E +  ++ L K  E + +E++ +     E   + +   L  L++++K+  + + 
Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL--LEKQMKEKENDLQ 767

Query: 617 ESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAER 676
           E F +L+ E ++L  E+K+   +++K       ++  +++ E+ I  +  K K K     
Sbjct: 768 EKFAQLEAENSILKDEKKT-LEDMLK-------IHTPVSQEERLIFLDSIKSKSKDSVWE 819

Query: 677 EKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHE-SR 735
           +++E L E   + K Q          QL +++++  +      K+FE + +Q+L+ E + 
Sbjct: 820 KEIEILIEENEDLKQQC--------IQLNEEIEKQRNTFSFAEKNFE-VNYQELQEEYAC 870

Query: 736 LDEEKENLTQQLLREVAEYQRNIVSRKEKI-------------SALKKQANHIVQQAQRE 782
           L + K++L     ++  EY+  + +  E++             S++  +    V +    
Sbjct: 871 LLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEM 930

Query: 783 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS 815
            +   K+   L+  L+  K     L ++ S LS
Sbjct: 931 GEVVEKDTTELMEKLEVTKREKLELSQRLSDLS 963



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 100/565 (17%), Positives = 220/565 (38%), Gaps = 70/565 (12%)

Query: 555  SSTFPKASSESSYLSILPKT--PEGISEEQR-------SQELAAMEETRIVILNN-LEEL 604
            S+T    SSE +  S + +T  P  +  E+        S++ A    T + ++ + L   
Sbjct: 108  STTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGK 167

Query: 605  KQKIKDINDQMDE-----------SFRELDMECALLDGEQKSETTELMKEKEILDHLNRK 653
            + +I+++N +++E             +E +      DG     T  L + +   D   R+
Sbjct: 168  QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMRE 227

Query: 654  IAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQL---QQQLKR 710
              EL        T++  KL  + ++L+  + L +   +         ++Q+   QQQL+ 
Sbjct: 228  FLEL--------TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 279

Query: 711  DADLLDVESKHFEDLEFQ-----------QLEHESRLD-------EEKENLTQQLLREVA 752
               LL+   K  ED   Q           ++E + +++       +EKE + ++L  ++ 
Sbjct: 280  QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKII 339

Query: 753  EYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYS 812
            E ++  +  K+K++   K    + +Q  ++       K  L    Q+E+++   +++   
Sbjct: 340  EEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMG 399

Query: 813  SLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ 872
            ++       +     K+     + +              Q  A+ D +  +    V   Q
Sbjct: 400  TVE-----ELQKRNHKDSQFETDIVQRM--EQETQRKLEQLRAELDEMYGQ--QIVQMKQ 450

Query: 873  PQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQS 932
               ++H   +EE K +HK      +     ++ S+I+ +     +      + ++ L  +
Sbjct: 451  ELIRQHMAQMEEMKTRHK-----GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDT 505

Query: 933  NSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYP 992
            NS    L   L  + ++  + +       +++S   R++ +   +T +E    LN  H  
Sbjct: 506  NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS-REQIQRARQTIAEQESKLNEAHKS 564

Query: 993  DHSYKDQAFDTLSL-DSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAE--- 1048
              + +D   + +S  +S   +E    A   +           +   ++R+ +   AE   
Sbjct: 565  LSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELER 624

Query: 1049 -KTRLLESREREMEAKKRALEEEKR 1072
             +T+LL S E E+   K  LE E R
Sbjct: 625  LRTQLLFSHEEELSKLKEDLEIEHR 649



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 56/246 (22%), Positives = 110/246 (44%), Gaps = 53/246 (21%)

Query: 581  EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640
            +++ Q    M + +IV L  + E K     ++    E+ +E    C      Q ++T   
Sbjct: 2526 QEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFC------QDNQTISS 2579

Query: 641  MKEKEILDHLNR---------------KIAELEKNIVGEKT-----KEKVKLDAEREKLE 680
              E+  + +LN+               +I+ELE  +V   T     KE+V++ AE+  LE
Sbjct: 2580 EPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEI-AEKNVLE 2638

Query: 681  RLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV---------ESKHFEDLEFQQLE 731
            + ++L   QK  L+   +  RE+ +++  +D ++L           ES  F +LE  + E
Sbjct: 2639 KEKKLLELQKL-LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE 2697

Query: 732  HES-------------RLDEE---KENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI 775
              +             +L EE   KE     L +++++ + ++   KEK+S L+K+    
Sbjct: 2698 SVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE 2757

Query: 776  VQQAQR 781
            VQ++++
Sbjct: 2758 VQESKK 2763



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 84/429 (19%), Positives = 161/429 (37%), Gaps = 106/429 (24%)

Query: 431  RQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKL--QL 488
            +Q  E LR+  M ++ERQR                        ED +++ +E+++L  QL
Sbjct: 1602 QQATELLRQAHMRQMERQR------------------------EDQEQLQEEIKRLNRQL 1637

Query: 489  SDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASFFTPRSTRNDELL 544
            +   S+  E L+S   R      ++L    LA     C  L  SS    T     N   +
Sbjct: 1638 AQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ--TQNGNENQGEV 1695

Query: 545  SDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEEL 604
             +          TF +          L + PE +  E  S E  A+++    +L  L E+
Sbjct: 1696 EE---------QTFKEKE--------LDRKPEDVPPEILSNERYALQKANNRLLKILLEV 1738

Query: 605  KQKIKDINDQ--------MDESFRELDMECALLDGEQKSETTELMKE-------KEILDH 649
             +    + +         +D S +       +   E ++     + E       + I  +
Sbjct: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798

Query: 650  LNRKIAELEKNIVGEKTKEKVKL--------------DAEREKL------------ERLQ 683
                +   + N+  + T+E  +L              D E E+L            E+L 
Sbjct: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLL 1858

Query: 684  ELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEE---- 739
            E  SE  +QL++   +  E +++  ++  +    ES   ++   ++L  ESR  E+    
Sbjct: 1859 EAISETSSQLEHAKVTQTELMRESFRQKQEA--TESLKCQEELRERLHEESRAREQLAVE 1916

Query: 740  ---KENLTQQLLREVAEYQRNIVSRKEKISALKKQ---ANHIVQQAQREQDHFVKEKNNL 793
                E +      E   ++R I  + + I  L+++   A++ +Q+ + EQ    +E+   
Sbjct: 1917 LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE-- 1974

Query: 794  IMMLQREKE 802
              +L R+KE
Sbjct: 1975 --LLSRQKE 1981



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 75/349 (21%), Positives = 140/349 (40%), Gaps = 45/349 (12%)

Query: 474  EDVQKINKE--LEKLQLSDEESV-FEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSA 530
            E  QKI  +  L   QLS+E+    E  ++    + R     S  D +      L  S  
Sbjct: 3272 ESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3331

Query: 531  SFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS---QEL 587
            +  +     +++LL +L +      S   +  +E+    +         E+ R    + L
Sbjct: 3332 TGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTL 3391

Query: 588  AAMEETRIVILNNLEELKQKIKDINDQMDESFRE---LDMECALLDG------EQKSETT 638
               +E        + EL+ K++D+  Q++E  ++   LD+E   L G      +Q+ E  
Sbjct: 3392 QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3451

Query: 639  ELMKEKEIL-DHLNRKIA-----------ELEKNIVGEKTKEK-----VKLDAE----RE 677
            E  + + IL  +LN                L++ I GE TKE      ++++        
Sbjct: 3452 EKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGE-TKESNYAKLIEMNGGGTGCNH 3510

Query: 678  KLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK------HFEDLEFQQLE 731
            +LE +++      ++L   P+   E+LQ +   D D + V+          + L  QQ E
Sbjct: 3511 ELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGE 3570

Query: 732  HESRLDEEKE--NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ 778
              S +       +LT++LLR+ AE   +I    E+ + L+     + +Q
Sbjct: 3571 EPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3619



 Score = 39.3 bits (90), Expect = 0.024
 Identities = 97/488 (19%), Positives = 190/488 (38%), Gaps = 69/488 (14%)

Query: 363 NPSH-----SLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS 417
           +P+H     S LAG+   +    R      V +    L+ L++     + A+++R   I+
Sbjct: 153 SPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEF----EAAIKQRDGIIT 208

Query: 418 SISGRDDLMDYHRRQREERLRE---------------QEMERLERQRLETILSLCAEYTK 462
            ++     +   RR+++E +RE               Q+++  E  R  T  S  A+  +
Sbjct: 209 QLTAN---LQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQ 265

Query: 463 PDSRLSTGTT--------VEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 514
              ++ T           +ED QK  KE   +Q+S  +   +   M  D +     K+ +
Sbjct: 266 AKQQILTHQQQLEEQDHLLEDYQK-KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 324

Query: 515 PDAD-----LASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLS 569
            + +     L +     +        + T  D+LL +L       +        E +   
Sbjct: 325 QEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTN-- 382

Query: 570 ILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALL 629
              K  E  S E+  Q +  +EE +     N ++ + +   +     E+ R+L+   A L
Sbjct: 383 --SKQKERQSSEEIKQLMGTVEELQ---KRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437

Query: 630 DGEQKSETTELMKEKEILDHL-------NRKIAELEK------NIVGEKTKEKVKLDAER 676
           D E   +    MK++ I  H+        R   E+E       NI   + + K+   A  
Sbjct: 438 D-EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN 496

Query: 677 EKLERLQELYSEQKTQLDNCPESMREQ--LQQQLKRDADLLDVESKHFEDLEFQQLEHES 734
           E   +LQ+  S+++   +     + E+  LQ+QL+   + L    +  +       E ES
Sbjct: 497 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQES 556

Query: 735 RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLI 794
           +L+E  ++L+      V + +  IVS  E    L+ +    V   + + +   KEKN ++
Sbjct: 557 KLNEAHKSLST-----VEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611

Query: 795 MMLQREKE 802
             +   +E
Sbjct: 612 DRMAESQE 619



 Score = 38.5 bits (88), Expect = 0.041
 Identities = 100/540 (18%), Positives = 212/540 (39%), Gaps = 72/540 (13%)

Query: 603  ELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN-I 661
            + K++ K ++ ++ E  +E+ +          S+  ++ + K+ +  ++ ++   +K  I
Sbjct: 1509 KFKEEFKPLSKELGEHGKEILLS--------NSDPHDIPESKDCVLTISEEMFSKDKTFI 1560

Query: 662  VGEKTKEKVK---LDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV- 717
            V +   +++    +DA R+ +   ++L            E MR++L +Q +      ++ 
Sbjct: 1561 VRQSIHDEISVSSMDASRQLMLNEEQL------------EDMRQELVRQYQEHQQATELL 1608

Query: 718  ESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ 777
               H   +E +Q E + +L EE + L +QL +  +    N+VS +E++   + +A   + 
Sbjct: 1609 RQAHMRQME-RQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLS 1667

Query: 778  QAQREQDHFVKEKNNLIMMLQREKENLCNLEK---KYSSLSGGKGFPVNPNTLKEGYISV 834
             A RE+     E  N     Q   EN   +E+   K   L   K   V P  L     ++
Sbjct: 1668 LAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELD-RKPEDVPPEILSNERYAL 1724

Query: 835  NEINE------------PCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSL 882
             + N                    +        D  + +   A+ +  S+ ++       
Sbjct: 1725 QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVH 1784

Query: 883  EERKKQHKEGL--YLSDTLPR----------KKTTSSISPHFSSATMGRSITPK-AHLPL 929
            EE  +   E +  Y    +PR          ++ T        S   G  I P+   L L
Sbjct: 1785 EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELML 1844

Query: 930  GQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSF 989
              S+   + +   L A+++ S      +    + M E  RQK E     A+ES       
Sbjct: 1845 NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQE-----ATESLKCQEEL 1899

Query: 990  HYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEK 1049
                H  + +A + L+++ S +          D  +   T    +I+E   ++ +   E 
Sbjct: 1900 RERLHE-ESRAREQLAVELSKAEGVI------DGYADEKTLFERQIQEKTDIIDRLEQE- 1951

Query: 1050 TRLLESREREMEAKKRALEEEKRRREILEKRLQEETS--QRQKLIEKEVKIRERQRAQAR 1107
                 +R +E+EA+++ ++EE+      ++ ++ E    ++Q L E E  ++E+   Q +
Sbjct: 1952 LLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 32/154 (20%), Positives = 74/154 (48%), Gaps = 22/154 (14%)

Query: 590  MEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDH 649
            ++E  +V   N+  L++ +  + D + E+  +L    ++L+ E ++E  E  K+  + + 
Sbjct: 2715 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKL----SILEKEDETEVQE-SKKACMFEP 2769

Query: 650  LNRKIAELEKNIVGEKTKEKVKLDAEREKLERL-----------QELYSEQKTQLDNCPE 698
            L  K+++     +  +T   +K+ +  +  + L            E  SE+ T++ +   
Sbjct: 2770 LPIKLSKS----IASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFT 2825

Query: 699  SMREQLQQQLKRDADLLDVESKHFEDLEFQQLEH 732
               E++Q+     A++LD+ES+H  + E  + EH
Sbjct: 2826 EKIEKMQEL--HAAEILDMESRHISETETLKREH 2857



 Score = 32.7 bits (73), Expect = 2.2
 Identities = 80/406 (19%), Positives = 151/406 (37%), Gaps = 64/406 (15%)

Query: 586  ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
            E+   +E    +LN + E   K+  +  ++ + + +      L  GE+      L KE+ 
Sbjct: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEEN-----LPKEET 1302

Query: 646  ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLE-RLQELYSEQKTQLDNCPESMREQL 704
                ++ ++  LE   V  K+K     D E+ KLE ++QEL            ES+   L
Sbjct: 1303 EFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL------------ESLISSL 1350

Query: 705  QQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEK 764
            QQQLK      + E    +    ++L+  S            ++   ++ QR +      
Sbjct: 1351 QQQLKETEQNYEAEIHCLQ----KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPG--- 1403

Query: 765  ISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE-----KENLCNL----------EK 809
             S +KK  +  ++ +    +  VKE+ N++ +L+++     +E +  +          + 
Sbjct: 1404 -SCVKKNIDGTIEFS---GEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQT 1459

Query: 810  KYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVL 869
            + S +SGG          KE   S  + +  C    +     +   D     T     V 
Sbjct: 1460 ELSRISGG----------KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDV- 1508

Query: 870  ASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR-----KKTTSSISPHFSSATMGRSITPK 924
                + KE F+ L +   +H + + LS++ P      K    +IS    S      +   
Sbjct: 1509 ----KFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQS 1564

Query: 925  AHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQ 970
             H  +  S+   S          +D     + +   HQQ +E  RQ
Sbjct: 1565 IHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQ 1610


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 124/702 (17%), Positives = 289/702 (41%), Gaps = 127/702 (18%)

Query: 475  DVQKINKELEKLQLS------DEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528
            +++++N+ELE+++++       +   FE A+   D                   G ++Q 
Sbjct: 170  EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRD-------------------GIITQL 210

Query: 529  SASFFTPRSTRNDELLSDLTRTPPPP-----------SSTFPKASSESSYLSILPKTPEG 577
            +A+    R  +++ +   L  T               S T   ++  S+   +L    + 
Sbjct: 211  TANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQI 270

Query: 578  ISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSET 637
            ++ +Q+ +E   +          LE+ ++K +D   Q+  SF +  ++   ++ ++K E 
Sbjct: 271  LTHQQQLEEQDHL----------LEDYQKKKEDFTMQI--SFLQEKIKVYEMEQDKKVEN 318

Query: 638  T---ELMKEKEILDHLNRKIAELEKNIVGEKTK----EKVKLDAEREKLERLQELYSEQK 690
            +   E+ +++ I++ LN KI E EK  +  K K    +K+  + + + +++ QE+    K
Sbjct: 319  SNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEI-KNMK 377

Query: 691  TQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLRE 750
             +L N  +  R+  ++  +    + +++ ++ +D +F+  +   R+++E +   +QL  E
Sbjct: 378  LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET-DIVQRMEQETQRKLEQLRAE 436

Query: 751  VAE-YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEK 809
            + E Y + IV  K+++        H+ Q  +               M  R K  + N  +
Sbjct: 437  LDEMYGQQIVQMKQELIR-----QHMAQMEE---------------MKTRHKGEMENALR 476

Query: 810  KYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVL 869
             YS+++      VN + +K   +++NE+N    ++   S   +   +   +  E      
Sbjct: 477  SYSNIT------VNEDQIKLMNVAINELNIKLQDTN--SQKEKLKEELGLILEEKCALQR 528

Query: 870  ASQPQSKEHFRSLEE----RKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKA 925
              +   +E   S E+    R+   ++   L++      T   +     SA+  R      
Sbjct: 529  QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588

Query: 926  H----------LPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFY 975
            H          L + +     +VL     +   + E  R    ++H++     ++  E  
Sbjct: 589  HEAEVTNYKIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647

Query: 976  NRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTS---NI 1032
            +R   E        HY       Q  D L  + S  +ET       DN+ +        I
Sbjct: 648  HRINIEKLKDNLGIHYK------QQIDGLQNEMSQKIETM--QFEKDNLITKQNQLILEI 699

Query: 1033 ARIEEMERLLKQAHAEKTRL-----------LESREREMEAKKRALEEEKRRREILEKRL 1081
            ++++++++ L  + +E+  L           L   E+E    ++ ++E + + E+LEK++
Sbjct: 700  SKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQM 759

Query: 1082 QE-ETSQRQKLIEKEVK---IRERQRAQARPLTRYLPVRKED 1119
            +E E   ++K  + E +   +++ ++     L  + PV +E+
Sbjct: 760  KEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEE 801



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 64/267 (23%), Positives = 125/267 (46%), Gaps = 38/267 (14%)

Query: 581  EQRSQELAAMEETRIVILNNLEELK---QKIKDINDQMDESFRELDMECALLDGEQKSET 637
            ++++  +  +E+  +   N L+EL+   Q+I++  + +      +  E   ++ +   ET
Sbjct: 1939 QEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQET 1998

Query: 638  TELMKEK--------EILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQ 689
             +LMKEK        ++ D L +++  LE ++  + ++    ++ E+EK   L +L  +Q
Sbjct: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRF---IELEQEKNTELMDL-RQQ 2054

Query: 690  KTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL----------EHESRLDE- 738
               L+   E MR+ L +Q        DV  +  + LE QQL          EH++R  E 
Sbjct: 2055 NQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE-QQLKVVPRFQPISEHQTREVEQ 2113

Query: 739  ------EKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ-AQREQDHF----V 787
                  EK +   +LL    + QR+I  R E+I  L+ +   + Q     ++ HF     
Sbjct: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEA 2173

Query: 788  KEKNNLIMMLQREKENLCNLEKKYSSL 814
            K + +L + LQ E++ +   EK+ ++L
Sbjct: 2174 KPELSLEVQLQAERDAIDRKEKEITNL 2200



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 114/571 (19%), Positives = 230/571 (40%), Gaps = 91/571 (15%)

Query: 581  EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDE-SFRELDMECALLDGEQK----- 634
            EQ +  L    +    +L + E+L++ I++ N+++++  FR  ++E ALL  ++K     
Sbjct: 2112 EQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAV 2171

Query: 635  ------SETTELMKEKEILDHLNRKIAELEKNI------VGEKTKEKVKLDAE-----RE 677
                  S   +L  E++ +D   ++I  LE+ +      +  K +E  +L  +     +E
Sbjct: 2172 EAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKE 2231

Query: 678  KLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHES--- 734
               RLQEL  E K   D+      E+L   +K ++D +  + +H    +F Q+  E    
Sbjct: 2232 STTRLQELEQENKLFKDDM-----EKLGLAIK-ESDAMSTQDQHVLFGKFAQIIQEKEVE 2285

Query: 735  --RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ---REQDHFVKE 789
              +L+E+   L QQL  ++    + I  + E I  L+ Q   ++   +   R ++  +++
Sbjct: 2286 IDQLNEQVTKLQQQL--KITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2343

Query: 790  KNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISV-NEINEPCGNSTNLS 848
             N +I  LQ+E  N+            G+   +N ++L E   S+ ++++        L 
Sbjct: 2344 LNEVIEKLQQELANI------------GQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2391

Query: 849  PSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSI 908
               +   +                 Q  +   SL    K+ +E +    ++P      +I
Sbjct: 2392 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSL----KRERESVEKIQSIPENSVNVAI 2447

Query: 909  SPHFS----------SATMGRSITPKAHLPLGQSNSCGSV-------LPPSLAAMAKDSE 951
              H S          +    +S+  + +    + N  GS+       L       AKD E
Sbjct: 2448 D-HLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLE 2506

Query: 952  SR---RMLRGYNHQQMSEGHRQKSEFYN---------RTASESNVYLNSFHYPDHSYKDQ 999
                 + ++    Q   E    + +  N           A  S + L +    +++   Q
Sbjct: 2507 LTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQ--EYAKFCQ 2564

Query: 1000 AFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESRERE 1059
               T+S +   +   +++    D + S  ++   RI E+E  + + H   T L+  +E+ 
Sbjct: 2565 DNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMH---TSLILEKEQV 2621

Query: 1060 MEAKKRALEEEKRRREILEKRLQEETSQRQK 1090
              A+K  LE+EK+  E+ +     E  QR+K
Sbjct: 2622 EIAEKNVLEKEKKLLELQKLLEGNEKKQREK 2652



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 125/600 (20%), Positives = 240/600 (40%), Gaps = 107/600 (17%)

Query: 394  DLESLRQAS--GTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 451
            +LE+L+Q S  G  +     R SS  + +G ++  +      E+  +E+E++R       
Sbjct: 1659 ELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVE----EQTFKEKELDRKPEDVPP 1714

Query: 452  TILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRK 511
             ILS        + R +       + KI  E+ K   + EE++    L   D   +    
Sbjct: 1715 EILS--------NERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSS 1766

Query: 512  DSL-----PDADLASCGS------LSQSSASFFTPRSTRND------------ELLSDLT 548
             SL      +A + SC          +S  S+      RND            EL   L 
Sbjct: 1767 ASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLV 1826

Query: 549  R-----TPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIV------- 596
            R     T   P +     +  S   + + K  E ISE     E A + +T ++       
Sbjct: 1827 RSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQK 1886

Query: 597  -----ILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETT---ELMKEKEILD 648
                  L   EEL++++ + +   ++   EL     ++DG    +T    ++ ++ +I+D
Sbjct: 1887 QEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIID 1946

Query: 649  HLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYS------------------EQK 690
             L +++     N + E   E+ ++  ERE L R +E                     ++K
Sbjct: 1947 RLEQELL-CASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEK 2005

Query: 691  TQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKEN--LTQQL- 747
             ++    E +R+ LQ+Q+K  A  +DVE +    +E +Q ++   +D  ++N  L +QL 
Sbjct: 2006 LEVQCQAEKVRDDLQKQVK--ALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLE 2063

Query: 748  -----LREVA---EYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQR 799
                 L E A   E++R++   +++I  L++Q   +V + Q   +H  +E   L   L +
Sbjct: 2064 KMRKFLDEQAIDREHERDVF--QQEIQKLEQQLK-VVPRFQPISEHQTREVEQLANHL-K 2119

Query: 800  EKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINE-----------PCGNSTNLS 848
            EK + C+ E   S     +        +++    V E+ +                  LS
Sbjct: 2120 EKTDKCS-ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELS 2178

Query: 849  PSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSI 908
               Q  A+ DA+  +     + +  +  E FR   E K +  + L++   + +K++T+ +
Sbjct: 2179 LEVQLQAERDAI--DRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 2236



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 101/498 (20%), Positives = 202/498 (40%), Gaps = 95/498 (19%)

Query: 390  FDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLER 447
            + + +  S++Q S   +P L ERK+ I++IS   DL+   + QRE  + +  Q  E    
Sbjct: 2957 YSDGEDHSIQQVS---EPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSD 3013

Query: 448  QRLETILSLCAEYTKPDSRL---------STGTT-------------VEDVQKINKELEK 485
             R E +L+L   + +  S L         + GTT              E   +    +E 
Sbjct: 3014 WRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMEC 3073

Query: 486  LQLSDEESVFEE------ALMSPDTRYRCHRKDSLPDADLASCGSLSQSS--------AS 531
            LQ +D  S+  E       +       +  ++   P  +L       + S         S
Sbjct: 3074 LQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3133

Query: 532  FFTPRSTRND-----------ELLSDLTRTPPPPSSTFPKASS-----ESSYLSILPKTP 575
                R+T              EL S+L +T     +T           E+  L +  KT 
Sbjct: 3134 SMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTD 3193

Query: 576  EG-------ISEEQRSQELA-AMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECA 627
            E         SE+++S+EL  A+E+ +  +  + E  K++++D+   + ES ++ +++  
Sbjct: 3194 EVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSL-ESQKQRNLQLN 3252

Query: 628  LL---------DGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVK-----LD 673
            LL         + +QK E+  ++ + ++ +   R    LE  ++ E  K +++     LD
Sbjct: 3253 LLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGR---NLELQVLLESEKVRIREMSSTLD 3309

Query: 674  AEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHE 733
             ERE   +LQ      +++     E + ++LQ+QL         E KH   +E      +
Sbjct: 3310 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL---------EEKHSRIVELLNETEK 3360

Query: 734  SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNL 793
             +LD  +   T+Q + +  +  R  +  +++ +   ++  H +Q    +    ++EK   
Sbjct: 3361 YKLDSLQ---TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3417

Query: 794  IMMLQREKENLCNLEKKY 811
            +  L  E + L  + +++
Sbjct: 3418 VYKLDLEGQRLQGIMQEF 3435



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 89/438 (20%), Positives = 180/438 (41%), Gaps = 59/438 (13%)

Query: 398  LRQASGTPQPALRERKSSISSISGRDDLMDYHRRQ---REERLREQEMERLERQRLETIL 454
            L +A G       E+      I  + D++D   ++      RL+E E E+ + Q    +L
Sbjct: 1917 LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL 1976

Query: 455  SLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 514
            S   E  K ++       +++ +K+ KE  ++Q   E+                  +D L
Sbjct: 1977 SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKV-----------------RDDL 2019

Query: 515  PDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKT 574
                 A    + +  + F      +N EL+ DL +          K        +I  + 
Sbjct: 2020 QKQVKALEIDVEEQVSRFIELEQEKNTELM-DLRQQNQALEKQLEKMRKFLDEQAIDREH 2078

Query: 575  PEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQK 634
               + +    QE+  +E+   V+       + + +++ +Q+    +E   +C+ L   ++
Sbjct: 2079 ERDVFQ----QEIQKLEQQLKVVPRFQPISEHQTREV-EQLANHLKEKTDKCSELLLSKE 2133

Query: 635  SETTELMKEKEILDHLNRKIAELEKNIVGEKTKE------------KVKLDAEREKLERL 682
                ++ +  E ++ L  ++ ELE+ ++ E  K             +V+L AER+ ++R 
Sbjct: 2134 QLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK 2193

Query: 683  QELYSEQKTQLDNCPESMREQLQQQLKRDADL---LDVESKHFEDLEFQQLEHESRL--- 736
            +    ++ T L+   E  RE+L+ + +    L   L+++ K       Q+LE E++L   
Sbjct: 2194 E----KEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKE-STTRLQELEQENKLFKD 2248

Query: 737  DEEKENL---------TQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDH-F 786
            D EK  L         TQ       ++ + I  ++ +I  L +Q   + QQ +   D+  
Sbjct: 2249 DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKV 2308

Query: 787  VKEKNNLIMMLQREKENL 804
            ++EKN LI  L+ + E L
Sbjct: 2309 IEEKNELIRDLETQIECL 2326



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 80/453 (17%), Positives = 196/453 (43%), Gaps = 51/453 (11%)

Query: 388 VEFDEADLESLRQASGTPQPALRERKSSISSISG-RDDLMDYHRRQREERLREQ------ 440
           + F    ++  RQ     +  L E   S+S++   + +++     ++E  L+ +      
Sbjct: 537 LSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNY 596

Query: 441 --EMERLERQRLETILSLCAEYTKPD-SRLSTGTTVEDVQKINKELEKLQLSDEESVFEE 497
             ++E LE+++   +L   AE  + +  RL T       ++++K  E L++    ++ E+
Sbjct: 597 KIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINI-EK 654

Query: 498 ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSST 557
              +    Y+  + D L +       ++     +  T    + ++L+ ++++      S 
Sbjct: 655 LKDNLGIHYK-QQIDGLQNEMSQKIETMQFEKDNLIT----KQNQLILEISKLKDLQQSL 709

Query: 558 FPKASSESSY-LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMD 616
               S E +  ++ L K  E + +E++ +     E   + +   L  L++++K+  + + 
Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL--LEKQMKEKENDLQ 767

Query: 617 ESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAER 676
           E F +L+ E ++L  E+K+   +++K       ++  +++ E+ I  +  K K K     
Sbjct: 768 EKFAQLEAENSILKDEKKT-LEDMLK-------IHTPVSQEERLIFLDSIKSKSKDSVWE 819

Query: 677 EKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHE-SR 735
           +++E L E   + K Q          QL +++++  +      K+FE + +Q+L+ E + 
Sbjct: 820 KEIEILIEENEDLKQQC--------IQLNEEIEKQRNTFSFAEKNFE-VNYQELQEEYAC 870

Query: 736 LDEEKENLTQQLLREVAEYQRNIVSRKEKI-------------SALKKQANHIVQQAQRE 782
           L + K++L     ++  EY+  + +  E++             S++  +    V +    
Sbjct: 871 LLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEM 930

Query: 783 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS 815
            +   K+   L+  L+  K     L ++ S LS
Sbjct: 931 GEVVEKDTTELMEKLEVTKREKLELSQRLSDLS 963



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 100/565 (17%), Positives = 220/565 (38%), Gaps = 70/565 (12%)

Query: 555  SSTFPKASSESSYLSILPKT--PEGISEEQR-------SQELAAMEETRIVILNN-LEEL 604
            S+T    SSE +  S + +T  P  +  E+        S++ A    T + ++ + L   
Sbjct: 108  STTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGK 167

Query: 605  KQKIKDINDQMDE-----------SFRELDMECALLDGEQKSETTELMKEKEILDHLNRK 653
            + +I+++N +++E             +E +      DG     T  L + +   D   R+
Sbjct: 168  QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMRE 227

Query: 654  IAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQL---QQQLKR 710
              EL        T++  KL  + ++L+  + L +   +         ++Q+   QQQL+ 
Sbjct: 228  FLEL--------TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 279

Query: 711  DADLLDVESKHFEDLEFQ-----------QLEHESRLD-------EEKENLTQQLLREVA 752
               LL+   K  ED   Q           ++E + +++       +EKE + ++L  ++ 
Sbjct: 280  QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKII 339

Query: 753  EYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYS 812
            E ++  +  K+K++   K    + +Q  ++       K  L    Q+E+++   +++   
Sbjct: 340  EEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMG 399

Query: 813  SLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ 872
            ++       +     K+     + +              Q  A+ D +  +    V   Q
Sbjct: 400  TVE-----ELQKRNHKDSQFETDIVQRM--EQETQRKLEQLRAELDEMYGQ--QIVQMKQ 450

Query: 873  PQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQS 932
               ++H   +EE K +HK      +     ++ S+I+ +     +      + ++ L  +
Sbjct: 451  ELIRQHMAQMEEMKTRHK-----GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDT 505

Query: 933  NSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYP 992
            NS    L   L  + ++  + +       +++S   R++ +   +T +E    LN  H  
Sbjct: 506  NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS-REQIQRARQTIAEQESKLNEAHKS 564

Query: 993  DHSYKDQAFDTLSL-DSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAE--- 1048
              + +D   + +S  +S   +E    A   +           +   ++R+ +   AE   
Sbjct: 565  LSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELER 624

Query: 1049 -KTRLLESREREMEAKKRALEEEKR 1072
             +T+LL S E E+   K  LE E R
Sbjct: 625  LRTQLLFSHEEELSKLKEDLEIEHR 649



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 56/246 (22%), Positives = 110/246 (44%), Gaps = 53/246 (21%)

Query: 581  EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640
            +++ Q    M + +IV L  + E K     ++    E+ +E    C      Q ++T   
Sbjct: 2518 QEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFC------QDNQTISS 2571

Query: 641  MKEKEILDHLNR---------------KIAELEKNIVGEKT-----KEKVKLDAEREKLE 680
              E+  + +LN+               +I+ELE  +V   T     KE+V++ AE+  LE
Sbjct: 2572 EPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEI-AEKNVLE 2630

Query: 681  RLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV---------ESKHFEDLEFQQLE 731
            + ++L   QK  L+   +  RE+ +++  +D ++L           ES  F +LE  + E
Sbjct: 2631 KEKKLLELQKL-LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE 2689

Query: 732  HES-------------RLDEE---KENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI 775
              +             +L EE   KE     L +++++ + ++   KEK+S L+K+    
Sbjct: 2690 SVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE 2749

Query: 776  VQQAQR 781
            VQ++++
Sbjct: 2750 VQESKK 2755



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 84/429 (19%), Positives = 161/429 (37%), Gaps = 106/429 (24%)

Query: 431  RQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKL--QL 488
            +Q  E LR+  M ++ERQR                        ED +++ +E+++L  QL
Sbjct: 1602 QQATELLRQAHMRQMERQR------------------------EDQEQLQEEIKRLNRQL 1637

Query: 489  SDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASFFTPRSTRNDELL 544
            +   S+  E L+S   R      ++L    LA     C  L  SS    T     N   +
Sbjct: 1638 AQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ--TQNGNENQGEV 1695

Query: 545  SDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEEL 604
             +          TF +          L + PE +  E  S E  A+++    +L  L E+
Sbjct: 1696 EE---------QTFKEKE--------LDRKPEDVPPEILSNERYALQKANNRLLKILLEV 1738

Query: 605  KQKIKDINDQ--------MDESFRELDMECALLDGEQKSETTELMKE-------KEILDH 649
             +    + +         +D S +       +   E ++     + E       + I  +
Sbjct: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798

Query: 650  LNRKIAELEKNIVGEKTKEKVKL--------------DAEREKL------------ERLQ 683
                +   + N+  + T+E  +L              D E E+L            E+L 
Sbjct: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLL 1858

Query: 684  ELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEE---- 739
            E  SE  +QL++   +  E +++  ++  +    ES   ++   ++L  ESR  E+    
Sbjct: 1859 EAISETSSQLEHAKVTQTELMRESFRQKQEA--TESLKCQEELRERLHEESRAREQLAVE 1916

Query: 740  ---KENLTQQLLREVAEYQRNIVSRKEKISALKKQ---ANHIVQQAQREQDHFVKEKNNL 793
                E +      E   ++R I  + + I  L+++   A++ +Q+ + EQ    +E+   
Sbjct: 1917 LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE-- 1974

Query: 794  IMMLQREKE 802
              +L R+KE
Sbjct: 1975 --LLSRQKE 1981



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 75/349 (21%), Positives = 140/349 (40%), Gaps = 45/349 (12%)

Query: 474  EDVQKINKE--LEKLQLSDEESV-FEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSA 530
            E  QKI  +  L   QLS+E+    E  ++    + R     S  D +      L  S  
Sbjct: 3264 ESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3323

Query: 531  SFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS---QEL 587
            +  +     +++LL +L +      S   +  +E+    +         E+ R    + L
Sbjct: 3324 TGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTL 3383

Query: 588  AAMEETRIVILNNLEELKQKIKDINDQMDESFRE---LDMECALLDG------EQKSETT 638
               +E        + EL+ K++D+  Q++E  ++   LD+E   L G      +Q+ E  
Sbjct: 3384 QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3443

Query: 639  ELMKEKEIL-DHLNRKIA-----------ELEKNIVGEKTKEK-----VKLDAE----RE 677
            E  + + IL  +LN                L++ I GE TKE      ++++        
Sbjct: 3444 EKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGE-TKESNYAKLIEMNGGGTGCNH 3502

Query: 678  KLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK------HFEDLEFQQLE 731
            +LE +++      ++L   P+   E+LQ +   D D + V+          + L  QQ E
Sbjct: 3503 ELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGE 3562

Query: 732  HESRLDEEKE--NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ 778
              S +       +LT++LLR+ AE   +I    E+ + L+     + +Q
Sbjct: 3563 EPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3611



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 111/495 (22%), Positives = 198/495 (40%), Gaps = 87/495 (17%)

Query: 365  SHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS---SISG 421
            S  LL+ E  +     RN     +EF   +LE              E K  +S    +  
Sbjct: 2126 SELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQA 2185

Query: 422  RDDLMDYHRRQRE----ERLREQEMERLERQRLETI-LSLCAEYTKPDSRLSTGTTVEDV 476
              D +D  R+++E    E   EQ  E LE +  E   L +  E  K +S     T ++++
Sbjct: 2186 ERDAID--RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKEST----TRLQEL 2239

Query: 477  QKINK----ELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASF 532
            ++ NK    ++EKL L+ +ES   +A+ + D                     L    A  
Sbjct: 2240 EQENKLFKDDMEKLGLAIKES---DAMSTQDQHV------------------LFGKFAQI 2278

Query: 533  FTPRSTRNDELLSDLTRTPPPPSSTFPKASSE--SSYLSILPKTPEGISEEQ------RS 584
               +    D+L   +T+       T      E  +  +  L    E +  +Q      R 
Sbjct: 2279 IQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNRE 2338

Query: 585  QELAAMEETRIVILNNLEELKQKIK----DINDQMDESFRELDMECA-LLDGEQKSETT- 638
            +E+  + E    +   L  + QK       ++++ D    +LD+  A  L  EQ+ ET  
Sbjct: 2339 EEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETAN 2398

Query: 639  -ELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP 697
             E+   K +L   N K+ +L        T+E   L  ERE +E++Q +         +  
Sbjct: 2399 EEMTFMKNVLKETNFKMNQL--------TQELFSLKRERESVEKIQSIPENSVNVAIDHL 2450

Query: 698  ESMREQLQQQLKRDADLLDVES----KHFED--------LEFQQLEHESRLDEEKENLTQ 745
               + +L+  L  DA L  +E+    K FE+        LE + L+ ES +  +   LTQ
Sbjct: 2451 SKDKPELEVVLTEDA-LKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2509

Query: 746  -----QLLREVAEYQRNIVSRK----EKISALKKQANHIVQQAQRE--QDHFVKEKNNLI 794
                 + ++E  +++  ++ +K    +KI   +K A  +V Q Q E  Q++    ++N  
Sbjct: 2510 CYKQIKDMQEQGQFETEMLQKKIVNLQKI-VEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2568

Query: 795  MMLQREKENLCNLEK 809
            +  + E+ N+ NL +
Sbjct: 2569 ISSEPERTNIQNLNQ 2583



 Score = 39.3 bits (90), Expect = 0.024
 Identities = 97/488 (19%), Positives = 190/488 (38%), Gaps = 69/488 (14%)

Query: 363 NPSH-----SLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS 417
           +P+H     S LAG+   +    R      V +    L+ L++     + A+++R   I+
Sbjct: 153 SPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEF----EAAIKQRDGIIT 208

Query: 418 SISGRDDLMDYHRRQREERLRE---------------QEMERLERQRLETILSLCAEYTK 462
            ++     +   RR+++E +RE               Q+++  E  R  T  S  A+  +
Sbjct: 209 QLTAN---LQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQ 265

Query: 463 PDSRLSTGTT--------VEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 514
              ++ T           +ED QK  KE   +Q+S  +   +   M  D +     K+ +
Sbjct: 266 AKQQILTHQQQLEEQDHLLEDYQK-KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 324

Query: 515 PDAD-----LASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLS 569
            + +     L +     +        + T  D+LL +L       +        E +   
Sbjct: 325 QEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTN-- 382

Query: 570 ILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALL 629
              K  E  S E+  Q +  +EE +     N ++ + +   +     E+ R+L+   A L
Sbjct: 383 --SKQKERQSSEEIKQLMGTVEELQ---KRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437

Query: 630 DGEQKSETTELMKEKEILDHL-------NRKIAELEK------NIVGEKTKEKVKLDAER 676
           D E   +    MK++ I  H+        R   E+E       NI   + + K+   A  
Sbjct: 438 D-EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN 496

Query: 677 EKLERLQELYSEQKTQLDNCPESMREQ--LQQQLKRDADLLDVESKHFEDLEFQQLEHES 734
           E   +LQ+  S+++   +     + E+  LQ+QL+   + L    +  +       E ES
Sbjct: 497 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQES 556

Query: 735 RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLI 794
           +L+E  ++L+      V + +  IVS  E    L+ +    V   + + +   KEKN ++
Sbjct: 557 KLNEAHKSLST-----VEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611

Query: 795 MMLQREKE 802
             +   +E
Sbjct: 612 DRMAESQE 619



 Score = 38.5 bits (88), Expect = 0.041
 Identities = 100/540 (18%), Positives = 212/540 (39%), Gaps = 72/540 (13%)

Query: 603  ELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN-I 661
            + K++ K ++ ++ E  +E+ +          S+  ++ + K+ +  ++ ++   +K  I
Sbjct: 1509 KFKEEFKPLSKELGEHGKEILLS--------NSDPHDIPESKDCVLTISEEMFSKDKTFI 1560

Query: 662  VGEKTKEKVK---LDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV- 717
            V +   +++    +DA R+ +   ++L            E MR++L +Q +      ++ 
Sbjct: 1561 VRQSIHDEISVSSMDASRQLMLNEEQL------------EDMRQELVRQYQEHQQATELL 1608

Query: 718  ESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ 777
               H   +E +Q E + +L EE + L +QL +  +    N+VS +E++   + +A   + 
Sbjct: 1609 RQAHMRQME-RQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLS 1667

Query: 778  QAQREQDHFVKEKNNLIMMLQREKENLCNLEK---KYSSLSGGKGFPVNPNTLKEGYISV 834
             A RE+     E  N     Q   EN   +E+   K   L   K   V P  L     ++
Sbjct: 1668 LAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELD-RKPEDVPPEILSNERYAL 1724

Query: 835  NEINE------------PCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSL 882
             + N                    +        D  + +   A+ +  S+ ++       
Sbjct: 1725 QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVH 1784

Query: 883  EERKKQHKEGL--YLSDTLPR----------KKTTSSISPHFSSATMGRSITPK-AHLPL 929
            EE  +   E +  Y    +PR          ++ T        S   G  I P+   L L
Sbjct: 1785 EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELML 1844

Query: 930  GQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSF 989
              S+   + +   L A+++ S      +    + M E  RQK E     A+ES       
Sbjct: 1845 NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQE-----ATESLKCQEEL 1899

Query: 990  HYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEK 1049
                H  + +A + L+++ S +          D  +   T    +I+E   ++ +   E 
Sbjct: 1900 RERLHE-ESRAREQLAVELSKAEGVI------DGYADEKTLFERQIQEKTDIIDRLEQE- 1951

Query: 1050 TRLLESREREMEAKKRALEEEKRRREILEKRLQEETS--QRQKLIEKEVKIRERQRAQAR 1107
                 +R +E+EA+++ ++EE+      ++ ++ E    ++Q L E E  ++E+   Q +
Sbjct: 1952 LLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 32/154 (20%), Positives = 74/154 (48%), Gaps = 22/154 (14%)

Query: 590  MEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDH 649
            ++E  +V   N+  L++ +  + D + E+  +L    ++L+ E ++E  E  K+  + + 
Sbjct: 2707 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKL----SILEKEDETEVQE-SKKACMFEP 2761

Query: 650  LNRKIAELEKNIVGEKTKEKVKLDAEREKLERL-----------QELYSEQKTQLDNCPE 698
            L  K+++     +  +T   +K+ +  +  + L            E  SE+ T++ +   
Sbjct: 2762 LPIKLSKS----IASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFT 2817

Query: 699  SMREQLQQQLKRDADLLDVESKHFEDLEFQQLEH 732
               E++Q+     A++LD+ES+H  + E  + EH
Sbjct: 2818 EKIEKMQEL--HAAEILDMESRHISETETLKREH 2849



 Score = 32.7 bits (73), Expect = 2.2
 Identities = 80/406 (19%), Positives = 151/406 (37%), Gaps = 64/406 (15%)

Query: 586  ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
            E+   +E    +LN + E   K+  +  ++ + + +      L  GE+      L KE+ 
Sbjct: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEEN-----LPKEET 1302

Query: 646  ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLE-RLQELYSEQKTQLDNCPESMREQL 704
                ++ ++  LE   V  K+K     D E+ KLE ++QEL            ES+   L
Sbjct: 1303 EFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL------------ESLISSL 1350

Query: 705  QQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEK 764
            QQQLK      + E    +    ++L+  S            ++   ++ QR +      
Sbjct: 1351 QQQLKETEQNYEAEIHCLQ----KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPG--- 1403

Query: 765  ISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE-----KENLCNL----------EK 809
             S +KK  +  ++ +    +  VKE+ N++ +L+++     +E +  +          + 
Sbjct: 1404 -SCVKKNIDGTIEFS---GEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQT 1459

Query: 810  KYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVL 869
            + S +SGG          KE   S  + +  C    +     +   D     T     V 
Sbjct: 1460 ELSRISGG----------KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDV- 1508

Query: 870  ASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR-----KKTTSSISPHFSSATMGRSITPK 924
                + KE F+ L +   +H + + LS++ P      K    +IS    S      +   
Sbjct: 1509 ----KFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQS 1564

Query: 925  AHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQ 970
             H  +  S+   S          +D     + +   HQQ +E  RQ
Sbjct: 1565 IHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQ 1610


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 89/439 (20%), Positives = 182/439 (41%), Gaps = 65/439 (14%)

Query: 474  EDVQKINKEL--EKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSAS 531
            ED ++IN EL  +K +L DE S  ++ +   +       K+             +++   
Sbjct: 928  EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEK----------HATENKVK 977

Query: 532  FFTPRSTRNDELLSDLTRTPPPPSSTFPKA----SSESSYLSILPKTPEGISEEQRSQEL 587
              T   +  DE ++ LTR          +A     +E   ++ L KT   + ++    E 
Sbjct: 978  NLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLES 1037

Query: 588  AAMEETRIVILNNLEELKQKIK--------------DINDQMDESFRELDMECALLDGEQ 633
            +  +E ++ +  +LE  K+K++              +   Q+DE  ++ D E   L  + 
Sbjct: 1038 SLEQEKKLRV--DLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKV 1095

Query: 634  KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQL 693
            + E T  ++ ++ +  L  +I ELE+ I  E+     +   E+++ +  +EL  E   +L
Sbjct: 1096 EDEQTLGLQFQKKIKELQARIEELEEEIEAERA---TRAKTEKQRSDYAREL-EELSERL 1151

Query: 694  DNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAE 753
            +        Q++   KR+A+ L +      DLE   L+HE+ +   ++           +
Sbjct: 1152 EEAGGVTSTQIELNKKREAEFLKLR----RDLEEATLQHEAMVAALRK-----------K 1196

Query: 754  YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSS 813
            +  ++    E+I  L++    + Q+ ++E+  F  E ++L   ++   ++  NLEK   +
Sbjct: 1197 HADSVAELGEQIDNLQR----VKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRT 1252

Query: 814  LSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQP 873
            L          + L E      EI       T      Q  A   +   E   ++++   
Sbjct: 1253 LE---------DQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLS 1303

Query: 874  QSKEHF-RSLEERKKQHKE 891
            +SK+ F +  EE K+Q +E
Sbjct: 1304 RSKQAFTQQTEELKRQLEE 1322



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 87/408 (21%), Positives = 182/408 (44%), Gaps = 52/408 (12%)

Query: 433  REERLREQEMERLERQRLETILSLCAEY-TKPDSRLSTGTTVEDVQKINKEL-EKLQLSD 490
            RE+   EQE +   ++ L    S  A++ TK ++     T  E++++  K+L ++LQ S+
Sbjct: 1345 REQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT--EELEEAKKKLAQRLQDSE 1402

Query: 491  E--ESVFEEALMSPDTRYRCHRK--DSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD 546
            E  E+V  +      T+ R   +  D + D + A+      S A+    +    D++L++
Sbjct: 1403 EQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERAN------SLAAALDKKQRNFDKVLAE 1456

Query: 547  LTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQ 606
                     +    +  ES  LS      +   EE       A+++   V   N + L+Q
Sbjct: 1457 WKTKCEESQAELEASLKESRSLSTELFKLKNAYEE-------ALDQLETVKREN-KNLEQ 1508

Query: 607  KIKDINDQMDES---FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVG 663
            +I D+ +Q+ E+     EL+     ++ E+      L + +  L+H   KI  ++  +  
Sbjct: 1509 EIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQ 1568

Query: 664  EKTKEKVKLDAEREKLERLQELYSE----QKTQLDNCPESMREQLQQQLKRDADLLDVE- 718
             K++   K+  + E++E+L+  Y       ++ LD    S  E ++ + K + DL ++E 
Sbjct: 1569 VKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEI 1628

Query: 719  ------------SKHFEDLEFQQLEHESRLDEE---KENLTQQLLREVAEYQRNIVSRK- 762
                         KH   ++ Q  + +  LD+    +E+L +QL   + E + N++  + 
Sbjct: 1629 QLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQL--AIVERRANLLQAEV 1686

Query: 763  EKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810
            E++ A  +Q     + A++E    + + N  + +L  +  +L + +KK
Sbjct: 1687 EELRATLEQTERARKLAEQE----LLDSNERVQLLHTQNTSLIHTKKK 1730



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 104/536 (19%), Positives = 211/536 (39%), Gaps = 73/536 (13%)

Query: 568  LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECA 627
            L +  ++   +  E+R  +L   +      +  + E  +  ++IN ++    R+L+ EC+
Sbjct: 890  LQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECS 949

Query: 628  LLDGE-QKSETTELMKEKE------ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLE 680
             L  +    E T    EKE       + +L  +++ L++ I     ++K   +A ++ L+
Sbjct: 950  ELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALD 1009

Query: 681  RLQ------ELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHES 734
             LQ         ++ K++L+   E +   L+Q+ K   DL   + K   DL+  Q E   
Sbjct: 1010 DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQ-ESIL 1068

Query: 735  RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLI 794
             L+ +K+ L ++L ++  EY + + S+ E    L  Q    +++ Q   +   +E     
Sbjct: 1069 DLENDKQQLDERLKKKDFEYCQ-LQSKVEDEQTLGLQFQKKIKELQARIEELEEE----- 1122

Query: 795  MMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFP 854
              ++ E+      EK+ S  +           L+E    ++E  E  G  T+        
Sbjct: 1123 --IEAERATRAKTEKQRSDYA---------RELEE----LSERLEEAGGVTSTQIELNKK 1167

Query: 855  ADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSS 914
             +A+ +                   R LEE   QH+  +       RKK   S++     
Sbjct: 1168 REAEFLKLR----------------RDLEEATLQHEAMV----AALRKKHADSVAELGEQ 1207

Query: 915  ATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEF 974
                + +  K      +       L  S+ +++K   +   +      Q+SE  R K+E 
Sbjct: 1208 IDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEA-RGKNEE 1266

Query: 975  YNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIAR 1034
              R+ SE               +     T + + S  +E   S  S   +S +  +   +
Sbjct: 1267 IQRSLSELTT------------QKSRLQTEAGELSRQLEEKESIVS--QLSRSKQAFTQQ 1312

Query: 1035 IEEMERLLKQAHAEKTRL---LESREREMEAKKRALEEEKRRREILEKRLQEETSQ 1087
             EE++R L++ +  K  L   L+S   + +  +   EEE+  +  L++ L +  S+
Sbjct: 1313 TEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE 1368



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 101/477 (21%), Positives = 184/477 (38%), Gaps = 69/477 (14%)

Query: 396  ESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLE--RQRLETI 453
            E  ++     Q AL +  S ++    + +     R +  E  +++  +RL+   +++E +
Sbjct: 1349 EEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAV 1408

Query: 454  LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQ--LSDEESVFEEALMSPDTRYRCHRK 511
             + CA   K   RL     VED+    +    L   L  ++  F++ L    T+  C   
Sbjct: 1409 NAKCASLEKTKQRLQG--EVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTK--CEES 1464

Query: 512  DSLPDADLASCGSLSQSSASFFTPRSTRNDEL-------------LSDLTRTPPPPSSTF 558
             +  +A L    SLS              D+L             ++DLT        T 
Sbjct: 1465 QAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTI 1524

Query: 559  PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 618
             +       + +     +   EE      AA+E     IL    EL Q   +I+ ++ E 
Sbjct: 1525 HELEKSRKQIELEKADIQLALEEAE----AALEHEEAKILRIQLELTQVKSEIDRKIAEK 1580

Query: 619  FRELD------------MECALLDGEQKSETTELMKEKEI----------LDHLNRKIAE 656
              E++            M+ AL D E +S    +  +K++          L H NR+ AE
Sbjct: 1581 DEEIEQLKRNYQRTVETMQSAL-DAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAE 1639

Query: 657  LEKN---IVGEKTKEKVKLDAEREKLERLQE---LYSEQKTQLDNCPESMREQLQQQLKR 710
              K+   + G+    ++ LD      E L+E   +   +   L    E +R  L+Q  + 
Sbjct: 1640 TLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERA 1699

Query: 711  ----DADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQ--QLLREVAEYQRNIVSRKEK 764
                + +LLD      E ++    ++ S +  +K+  T   QL  EV +  R+  + +EK
Sbjct: 1700 RKLAEQELLDSN----ERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEK 1755

Query: 765  ISALKKQANHIVQQAQREQD---HFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGK 818
                   A  + ++ ++EQD   H  + K NL   ++  +  L   E+   +L GGK
Sbjct: 1756 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ--LALKGGK 1810



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 39/184 (21%), Positives = 82/184 (44%), Gaps = 23/184 (12%)

Query: 584  SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKE 643
            ++EL   ++T   +    + L+Q +KD+  ++DE+                 E   L   
Sbjct: 1767 AEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA-----------------EQLALKGG 1809

Query: 644  KEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNC--PESMR 701
            K+ +  L  +I ELE  + GE+ K    +   R+   R++EL  + +    N    + + 
Sbjct: 1810 KKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLV 1869

Query: 702  EQLQ---QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI 758
            ++LQ   +  KR A+  D E  +    +F++ +HE    EE+ ++ +  + ++    R+ 
Sbjct: 1870 DKLQVKVKSYKRQAEEAD-EQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDF 1928

Query: 759  VSRK 762
             S +
Sbjct: 1929 TSSR 1932



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 80/377 (21%), Positives = 140/377 (37%), Gaps = 58/377 (15%)

Query: 748  LREVAEYQRNIVSRKEKISALKKQ-ANHIVQQAQREQD--HFVKEKNNLIMMLQREKENL 804
            L + AE ++ + + KE+    K + A    ++ + E+     V+EKN+L + +Q E ENL
Sbjct: 840  LLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENL 899

Query: 805  CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEP 864
             + E++   L   K F +           + E+ E   +   ++        A     E 
Sbjct: 900  LDAEERCDQLIKAK-FQLE--------AKIKEVTERAEDEEEINAE----LTAKKRKLED 946

Query: 865  ATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPK 924
              + L       E   +  E++K   E    + T    +  S +    +  T  +    +
Sbjct: 947  ECSELKKDIDDLELTLAKVEKEKHATENKVKNLT----EELSGLDETIAKLTREKKALQE 1002

Query: 925  AHL-----------PLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSE 973
            AH             +   N   S L   +  +    E  + LR        E +++K E
Sbjct: 1003 AHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLR-----VDLERNKRKLE 1057

Query: 974  FYNRTASESNVYL-NSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNI 1032
               + A ES + L N     D   K + F+   L S    E ++       I        
Sbjct: 1058 GDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQ---- 1113

Query: 1033 ARIEEMERLLKQAHAEKTRLLESRE---REMEAKKRALEE------------EKRRREIL 1077
            ARIEE+E  ++   A + +  + R    RE+E     LEE            +KR  E L
Sbjct: 1114 ARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFL 1173

Query: 1078 EKR--LQEETSQRQKLI 1092
            + R  L+E T Q + ++
Sbjct: 1174 KLRRDLEEATLQHEAMV 1190


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 151/727 (20%), Positives = 289/727 (39%), Gaps = 91/727 (12%)

Query: 137  ERALRLSE-KPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISR 195
            E+A+R+ + +   S+Y  R   HD  +    +E  K    +L +   + L D      +R
Sbjct: 317  EKAVRVDKLESEVSRYKER--LHDIEFYKARVEELKEDNQVL-LETKTMLEDQLEGTRAR 373

Query: 196  SGAASMPSSPKQARKMSIQDSLALQPKLTRHK--ELASENINLR-TRKYSSSSLSHMGAY 252
            S             K  + D + ++  + R K  EL  EN+ L   +K S     H+G  
Sbjct: 374  SDKLHELEKENLQLKAKLHD-MEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGW- 431

Query: 253  SRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGAL 312
               L ++ R +E     LS  P+ SLG+        + L   + +         L +   
Sbjct: 432  --ELEQISRTSE-----LSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484

Query: 313  PYKTSASE------GNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV------ 360
              + +AS+       N  +S  + +  +  V  K  L +  + + D   + + +      
Sbjct: 485  SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544

Query: 361  ---GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS 417
                +     +L  E++ +  T  +    S    EA ++ + + +     +++E  S +S
Sbjct: 545  LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604

Query: 418  SISG-----RDDLMDYHRRQREERLREQEMERLER-----QRLETILSLCAEYTKPDSRL 467
             I       + +L  Y  +       E E+  LE+     Q+  T L +  E  +   + 
Sbjct: 605  KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664

Query: 468  STGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYRCHRKDSLPDADLASCGSLS 526
            ++     ++++ N++L+K   S +   F+ E+L   +++      +   + +   C S+ 
Sbjct: 665  NS-----ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK 719

Query: 527  QSSASFFTPRSTRNDELLSD---LTRTPPPPSSTFPKASS-ESSYLSI------LPKTPE 576
             +           N EL S+   L +      ++F K    E SY  +      L KT E
Sbjct: 720  MAQLQL------ENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE 773

Query: 577  GISE--EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQK 634
              ++  +Q   EL  +E     +  NLEELK   K + +Q+++  + L+ E + L+ ++K
Sbjct: 774  NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL-EQLEKENKSLEQETSQLEKDKK 832

Query: 635  S---ETTELMKEKEI----LDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYS 687
                E   L ++ EI    L+  N KI  LEK     KT  K ++   +E   RL+EL  
Sbjct: 833  QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE---NKTLSK-EIGIYKESCVRLKELEK 888

Query: 688  EQKTQLDNCP------ESMREQL------QQQLKRDADLLDVESKHFEDLEFQQLEHESR 735
            E K  +           ++RE L       QQ+  D + L  E +     + + L  E  
Sbjct: 889  ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS 948

Query: 736  LDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIM 795
             D+ +  L +  L    +  +++  ++EKI+AL+ +        Q+ +      K N   
Sbjct: 949  TDDSRYKLLESKLESTLK--KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1006

Query: 796  MLQREKE 802
            + QR+ E
Sbjct: 1007 LKQRQDE 1013



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 92/453 (20%), Positives = 176/453 (38%), Gaps = 54/453 (11%)

Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREER--LREQEMERLERQR 449
           +A +  LRQ        L + K  +  +      ++  R Q+E    L +    R+ R  
Sbjct: 257 KAKIRRLRQELEEKTEQLLDCKQELEQME-----IELKRLQQENMNLLSDARSARMYRDE 311

Query: 450 LETILSLCAEYTKPDSRLST-GTTVEDVQKINKELEKLQLSDEESVFEEALMSPD----T 504
           L+ +        K +S +S     + D++     +E+L+  D + + E   M  D    T
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK-EDNQVLLETKTMLEDQLEGT 370

Query: 505 RYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKAS-- 562
           R R  +   L   +L     L          R    + +  ++T       S        
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430

Query: 563 ------SESSYLSILPKTPEGIS-EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQM 615
                 S +S LS  P+   G    E  S  L  +E     +   +EEL+  +  +    
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA 490

Query: 616 DESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAE 675
            +  + ++ E   L  + +    E+++EK+ L +       L K+++ EK + +  ++  
Sbjct: 491 SKILK-MEKENQRLSKKVEILENEIVQEKQSLQNCQN----LSKDLMKEKAQLEKTIETL 545

Query: 676 REKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVE-------------SKHF 722
           RE  ER  ++  ++   L+    S+R+  + Q+  +A + D+E             S   
Sbjct: 546 RENSERQIKILEQENEHLNQTVSSLRQ--RSQISAEARVKDIEKENKILHESIKETSSKL 603

Query: 723 EDLEFQ------QLEH---ESRLDEEKENLTQQLLREVAEYQRNIVSRK---EKISALKK 770
             +EF+      +LEH   +    EE EN    L +E    Q+ I + K   EKI AL++
Sbjct: 604 SKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663

Query: 771 QANHIVQQAQREQDHFVKEKNNLIMMLQREKEN 803
           + + + ++ ++ +      KN    +   EKEN
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKEN 696



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 116/567 (20%), Positives = 226/567 (39%), Gaps = 56/567 (9%)

Query: 586  ELAAMEETRIVILNNLEELKQKIKDINDQM-DESFRELDMECALLDGEQKSETTELMKEK 644
            EL A+ E  +     +++L+ ++    +++ D  F +  +E    D +   ET  +++++
Sbjct: 311  ELDALREKAV----RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 366

Query: 645  -EILDHLNRKIAELEKNIVGEKTK---EKVKLDAEREKLERLQELYSEQKTQLDNCPESM 700
             E     + K+ ELEK  +  K K    +++ D +R+K+E L E   E  T      +SM
Sbjct: 367  LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME---ENMTLEMAQKQSM 423

Query: 701  REQLQ-----QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQ 755
             E L      +Q+ R ++L +   K     E  +L     L  E EN  Q L + V E +
Sbjct: 424  DESLHLGWELEQISRTSELSEAPQKSLGH-EVNELTSSRLLKLEMEN--QSLTKTVEELR 480

Query: 756  RNIVS---RKEKISALKKQANHIVQQAQREQDHFVKEKN------NLIMMLQREKENLCN 806
              + S      KI  ++K+   + ++ +  ++  V+EK       NL   L +EK     
Sbjct: 481  TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK---AQ 537

Query: 807  LEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPAT 866
            LEK   +L          N+ ++  I   E        ++L   +Q  A+A     E   
Sbjct: 538  LEKTIETL--------RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589

Query: 867  AVL-ASQPQSKEHFRSLEERKKQHKEGL-YLSDTLPRKKTTSSISPHFSSAT--MGRSIT 922
             +L  S  ++      +E  K+Q K+ L +  +   R +   +   H       + + IT
Sbjct: 590  KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKIT 649

Query: 923  PKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASES 982
                       +C  +          + E+R++ +  +  +      +  E  N    E 
Sbjct: 650  -------NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE 702

Query: 983  NVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLL 1042
            N+ L   +             L L++ +             +  AS     R+E   + L
Sbjct: 703  NLELRR-NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL 761

Query: 1043 KQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQE--ETSQRQKLIEKEVKIRE 1100
               +    + LE+  ++++  +  L++ +   + L+K L+E   +S+R + +EKE K  E
Sbjct: 762  DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLE 821

Query: 1101 RQRAQARPLTRYLPVRKEDFDLRSHVE 1127
            ++ +Q     + L   KE+  LR   E
Sbjct: 822  QETSQLEKDKKQL--EKENKRLRQQAE 846



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 86/418 (20%), Positives = 180/418 (43%), Gaps = 80/418 (19%)

Query: 432 QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINK---------- 481
           +R+ ++ EQE E L     +T+ SL     +  S++S    V+D++K NK          
Sbjct: 550 ERQIKILEQENEHLN----QTVSSL-----RQRSQISAEARVKDIEKENKILHESIKETS 600

Query: 482 ------ELEKLQLSDEESVFEE----ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSAS 531
                 E EK Q+  E   ++E    A    +  +   +++ L    + +     +   +
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660

Query: 532 FFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQ-------RS 584
                    ++  S+L R       T     + +  L  L K    + EE         S
Sbjct: 661 L--------EQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712

Query: 585 QELAAMEETRIVILNN-LEELKQKIKD----------INDQMDESFRELDMECALLDGEQ 633
            + A+M+  ++ + N  LE  K+++K             ++++ S++ LD+E   L    
Sbjct: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772

Query: 634 KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAER-EKLERLQELYSEQKTQ 692
           ++   ++ + +  L  L  +   L+KN+      E++K+ ++R E+LE+  +   ++ +Q
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNL------EELKISSKRLEQLEKENKSLEQETSQ 826

Query: 693 LDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDE-EKENLTQQLLREV 751
           L    E  ++QL+++ KR     +++    E       E+  ++   EKEN T  L +E+
Sbjct: 827 L----EKDKKQLEKENKRLRQQAEIKDTTLE-------ENNVKIGNLEKENKT--LSKEI 873

Query: 752 AEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEK 809
             Y+ + V  KE    L+K+   +V++A  +    V  + +L+    + ++   +LEK
Sbjct: 874 GIYKESCVRLKE----LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 97/472 (20%), Positives = 195/472 (41%), Gaps = 49/472 (10%)

Query: 372  ESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRR 431
            E+ R+  T  N S   ++  E++L+ L   + T Q  L E K S   +          + 
Sbjct: 764  ENQRLQKTLEN-SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE---------QL 813

Query: 432  QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKI-NKELEKLQLSD 490
            ++E +  EQE  +LE+ + +  L    +  +  + +   T  E+  KI N E E   LS 
Sbjct: 814  EKENKSLEQETSQLEKDKKQ--LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871

Query: 491  EESVFEEALMSPDTRYRCHRKDSLPDA--DLASCGSLSQSSASFFTPRSTRNDELLSDLT 548
            E  +++E+ +      +   K+ +  A  D+ +  +L +   S        N++L   LT
Sbjct: 872  EIGIYKESCVRLKELEK-ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL-EKLT 929

Query: 549  RTPPPPSST-----FPKASSESSYLSILPKTPEGI---SEEQRSQELAAMEETRIVILNN 600
                            + S++ S   +L    E     S E + +++AA+E       N 
Sbjct: 930  HELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY 989

Query: 601  LEELKQKIKDIN------------DQMDESFRELDMECALLDGEQKSETTELMKEKEILD 648
             ++L+Q++K +             ++M +S   +  E    + E +  T EL+K K+ L 
Sbjct: 990  NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1049

Query: 649  HLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQL 708
             + R  A L+      KT+ K +L+ +   L+        Q   L     +++ Q   +L
Sbjct: 1050 EVERNNATLQAEKQALKTQLK-QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ-NAKL 1107

Query: 709  KRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISAL 768
            + +   L+ +S    +   Q L  +S L+ E E++ ++   ++     +++   EK+  L
Sbjct: 1108 QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE-REDLKSLYDSLIKDHEKLELL 1166

Query: 769  -KKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKG 819
             ++QA+        E +  + +   L    +  +    +LE +Y+ L   KG
Sbjct: 1167 HERQAS--------EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKG 1210



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 44/193 (22%), Positives = 94/193 (48%), Gaps = 17/193 (8%)

Query: 585  QELAAMEETRIVILN-NLEELKQKIKDI---NDQMDESFRELDMECALLDGEQKSETTEL 640
            +++  +E+ ++++ N N E +  + K +   ND+++ ++ +L  E  +L  + K+     
Sbjct: 1216 EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNL---- 1271

Query: 641  MKEKEILDHLNRKIAELEKNIVGEKTKEKVK-LDAEREKLERLQELYSEQKTQLDNCPES 699
               K +L+  N K+ +        K KE+ + LD    KL    EL S+ K  L+     
Sbjct: 1272 ---KSLLN--NSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1326

Query: 700  MREQLQQQLKRDADLLD--VESKHFEDLEFQQ-LEHESRLDEEKENLTQQLLREVAEYQR 756
            + +Q+Q  + ++  LL+  +ESK    +E +Q ++  + L  +KE L ++++ +   Y  
Sbjct: 1327 LLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDP 1386

Query: 757  NIVSRKEKISALK 769
            +   R+     LK
Sbjct: 1387 SPPRRRGNWITLK 1399



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 43/224 (19%), Positives = 103/224 (45%), Gaps = 30/224 (13%)

Query: 605  KQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGE 664
            ++ +K + D + +   +L+    LL   Q SE   L+ +   L   ++ + E+E   + +
Sbjct: 1146 REDLKSLYDSLIKDHEKLE----LLHERQASEYESLISKHGTLKSAHKNL-EVEHRDLED 1200

Query: 665  KTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFED 724
            +  + +K   + E LE++ ++  E+    +   E++  + ++    +  L    S+  ++
Sbjct: 1201 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1260

Query: 725  LEFQQLEHE--------SRLDEEKENLTQQLLREVAEYQR-NIVSRK-----EKISALK- 769
             E  Q +H+        S+L++ +       L+E  +YQ+ +I S K     E +S LK 
Sbjct: 1261 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE--QYQQLDITSTKLNNQCELLSQLKG 1318

Query: 770  ---KQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810
               ++  H++ Q Q      +  +N  ++    E ++L ++E++
Sbjct: 1319 NLEEENRHLLDQIQT-----LMLQNRTLLEQNMESKDLFHVEQR 1357


>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
          Length = 1780

 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 110/502 (21%), Positives = 204/502 (40%), Gaps = 81/502 (16%)

Query: 421  GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
            G D L+   ++ +E R++E   E      +E I   C E  K  S+ S       ++++ 
Sbjct: 990  GNDYLVS--KQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKS-----HQIEELE 1042

Query: 481  KELEKLQ------------LSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528
            +++EKLQ            L ++E   ++ L+          K+ L + ++     +   
Sbjct: 1043 QQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHV 1102

Query: 529  SASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELA 588
                           LS+LT+       T  KA  +     +  +  E     +  Q++ 
Sbjct: 1103 ---------VEGKRALSELTQ-----GVTCYKAKIKELETILETQKVECSHSAKLEQDIL 1148

Query: 589  AMEETRIVILNNLEELKQKIKD-INDQMDESFRELDMECALLDGEQKSETTELMKEKEIL 647
              E   + +  NL+E ++ ++D + +  D + +EL +         K E T+L    + +
Sbjct: 1149 EKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKL---------KEEITQLTNNLQDM 1199

Query: 648  DHLNRKIAELEKNIVGEKTKEKVKLDAE-------REKLERLQELYSEQKTQLDNCPESM 700
             HL +   E E+    E  K K +L A        +  L+R +E Y++ K +L +  + +
Sbjct: 1200 KHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQI 1259

Query: 701  RE-QLQQQLKRDAD-LLDVESKHFEDLE---FQQLEHESR-LDEEKENLTQQLLRE-VAE 753
            ++ Q +  + RD D LL ++    E  +    Q+L+ + R + + KE L  Q + E + +
Sbjct: 1260 KQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQ 1319

Query: 754  YQR--NIVSRKEKISALKKQANHIVQQAQREQDHFVKEK----NNLIMMLQREKENLCNL 807
            Y+R    ++ KEKI    +      +Q Q EQD  ++ K      L   L++ KE   +L
Sbjct: 1320 YERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDL 1379

Query: 808  EKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPA---DADAVATEP 864
            E K +  S  K    N + L              G  TNL    Q      +AD      
Sbjct: 1380 ETKNNQRS-NKEHENNTDVL--------------GKLTNLQDELQESEQKYNADRKKWLE 1424

Query: 865  ATAVLASQPQSKEHFRSLEERK 886
               +L +Q +  E+ R+ E +K
Sbjct: 1425 EKMMLITQAKEAENIRNKEMKK 1446



 Score = 37.4 bits (85), Expect = 0.091
 Identities = 62/306 (20%), Positives = 125/306 (40%), Gaps = 49/306 (16%)

Query: 559  PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN------LEELKQKIKDIN 612
            P A   S ++S      +  SEE R   +A +E+ R++  NN      L  ++ ++K+  
Sbjct: 804  PPAKKGSIHVSSAITEDQKKSEEVRPN-IAEIEDIRVLQENNEGLRAFLLTIENELKNEK 862

Query: 613  DQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAEL--EKNIVGEKTKEKV 670
            ++  E  +++      L   +K   T   + ++I  + +  IAEL  +K+   E+ ++ +
Sbjct: 863  EEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIM 922

Query: 671  KLDAERE------------------KLERLQELYSEQKTQLDNCPESMREQLQQQLKRD- 711
            KL  E E                  K++ L+ L  +  +Q+ N        L    + D 
Sbjct: 923  KLSNEIETATRSITNNVSQIKLMHTKIDELRTL--DSVSQISNIDLLNLRDLSNGSEEDN 980

Query: 712  -----ADLLDVE---SKHFEDLEFQQLEHESRLDEEKENLTQQLLR----------EVAE 753
                  DLL  +   SK  ++   Q+   E+      E + ++             ++ E
Sbjct: 981  LPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEE 1040

Query: 754  YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE-KENLCNLEKKYS 812
             ++ I   + ++   K + N + ++  + QD  +KEK  LI  L+ E +E    L+ +  
Sbjct: 1041 LEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQ 1100

Query: 813  SLSGGK 818
             +  GK
Sbjct: 1101 HVVEGK 1106



 Score = 32.0 bits (71), Expect = 3.8
 Identities = 21/88 (23%), Positives = 45/88 (51%), Gaps = 5/88 (5%)

Query: 1035 IEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--REILEKRLQEETSQRQKLI 1092
            +EE+E   +  + E   L E  ++ +E  K  +  E++R   +++E   ++  +++++ +
Sbjct: 536  VEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKL 595

Query: 1093 EKEVKIRERQRAQARPLTRYLPVRKEDF 1120
              E KIRE      +  T+Y   R+ DF
Sbjct: 596  TLEFKIREE---VTQEFTQYWAQREADF 620


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 101/452 (22%), Positives = 195/452 (43%), Gaps = 58/452 (12%)

Query: 392  EADLESLRQASGTPQPALRERKSSISSISGR-DDLMDYHRRQREE-RLREQEMERLERQR 449
            E +LE+ R A    +    E    +  +S R ++       QRE  R RE E+ RL R+ 
Sbjct: 1168 EEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRREL 1227

Query: 450  LETILSLCAEYT-----KPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDT 504
             E  L   A        + +     G  V+ +Q++ ++LEK     E+S   E  M  D 
Sbjct: 1228 EEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEK-----EKS---ELRMEVD- 1278

Query: 505  RYRCHRKDSLPDADLAS-CGSLSQSSASFFTPRSTRNDEL------LSDLTRTPPPPSST 557
                         DLA+   +L+++ AS      T  D+L      + +L R     S+ 
Sbjct: 1279 -------------DLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQ 1325

Query: 558  FPKASSESSYLSILPKTPEG-ISEEQRSQELAAMEETRIVILNNLEELKQKIKD---IND 613
              +  +ES  LS L +  E  IS+  R + LAA          +LEEL++++++      
Sbjct: 1326 RGRLQTESGELSRLLEEKECLISQLSRGKALAAQ---------SLEELRRQLEEESKAKS 1376

Query: 614  QMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLD 673
             +  + + L  +C LL  + + E     + + +L   N ++A+       +  +   +L+
Sbjct: 1377 ALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELE 1436

Query: 674  AEREKLE-RLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEF---QQ 729
              ++KL  RLQE  +E+  +  N   S  E+ + +L+ +++ + +E +          ++
Sbjct: 1437 EAKKKLALRLQE--AEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKK 1494

Query: 730  LEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALK---KQANHIVQQAQREQDHF 786
              H  R  EE+    +++ RE+   QR       ++  L+   ++A   ++  +RE  + 
Sbjct: 1495 QRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNL 1554

Query: 787  VKEKNNLIMMLQREKENLCNLEKKYSSLSGGK 818
             +E ++L   +    +++  LEK   +L G K
Sbjct: 1555 QEEISDLTDQVSLSGKSIQELEKTKKALEGEK 1586



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 164/785 (20%), Positives = 278/785 (35%), Gaps = 166/785 (21%)

Query: 396  ESLRQASGTPQPALRERKSSISSISGR--DDLMDYHRRQREERLREQEMERLERQRLETI 453
            E+ +QA G  Q A  +R S+++    R    + D      +E+    + ER +R +LE  
Sbjct: 1050 EAHQQALGDLQ-AEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKR-KLEGD 1107

Query: 454  LSLCAEYT---------------KPDSRLST-GTTVEDVQ----KINKELEKLQLSDEES 493
            L L  E                 K DS LS     VED Q    ++ K++++LQ   EE 
Sbjct: 1108 LKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEEL 1167

Query: 494  VFE-EALMSPDTRYRCHRKDSLPDAD-----LASCGSLSQSSASFFTPRSTRNDELLSDL 547
              E EA  +   R    R ++  + +     L   G  S         R      L  +L
Sbjct: 1168 EEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRREL 1227

Query: 548  TRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQK 607
                            E++  ++  K  EG +E    +++ +++  R  +     EL+ +
Sbjct: 1228 EEAA---------LRHEATVAALRRKQAEGAAE--LGEQVDSLQRVRQKLEKEKSELRME 1276

Query: 608  IKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTK 667
            + D+   ++   R      A    E+   T E     + L     K+ EL++ +    T 
Sbjct: 1277 VDDLAANVETLTR------AKASAEKLCRTYE-----DQLSEAKIKVEELQRQLADAST- 1324

Query: 668  EKVKLDAEREKLERLQE-------LYSEQKTQLDNCPESMREQLQQQLKRDADLLDVES- 719
            ++ +L  E  +L RL E         S  K       E +R QL+++ K  + L      
Sbjct: 1325 QRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQA 1384

Query: 720  -KHFEDLEFQQLEHESRLDEEKENLTQQLLREVAE----YQRNIVSRKEKISALKKQANH 774
             +H  DL  +Q E E+    E + L  +   EVA+    Y+ + + R E++   KK+   
Sbjct: 1385 LRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKK--- 1441

Query: 775  IVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISV 834
                              L + LQ  +E +     K SSL   K   +   T  E     
Sbjct: 1442 ------------------LALRLQEAEEGVEAANAKCSSLEKAK---LRLQTESEDV--- 1477

Query: 835  NEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQ------ 888
                     +  L  +T   A  D        A+   + Q +E  R LE  +++      
Sbjct: 1478 ---------TLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGT 1528

Query: 889  --------HKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPL--------GQS 932
                    H+E L   +TL  K+   ++    S  T   S++ K+   L        G+ 
Sbjct: 1529 ELFRLRHGHEEALEALETL--KRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEK 1586

Query: 933  NSCGSVLPPSLAAM--------------------------AKDSESRRMLRGYNHQQMSE 966
            +   + L  +  A+                           KD E   + R  NHQ+  E
Sbjct: 1587 SEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRR--NHQRAVE 1644

Query: 967  GHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISS 1026
              +   +   R  +E      +         D     L L  +    T   A +    + 
Sbjct: 1645 SLQASLDAETRARNE------ALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQ 1698

Query: 1027 ASTSNIARIEEMERLLKQAHAEKTRLLESR----EREMEAKKRALEEEKRRREILEKRLQ 1082
                   R EE +RL  + H E+ + LE R      E+E  + ALE+ +R R + E+ L 
Sbjct: 1699 LKEEQAGRDEE-QRLAAELH-EQAQALERRASLLAAELEELRAALEQGERSRRLAEQELL 1756

Query: 1083 EETSQ 1087
            E T +
Sbjct: 1757 EATER 1761



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 105/467 (22%), Positives = 174/467 (37%), Gaps = 71/467 (15%)

Query: 398  LRQASGTPQPALRERKSSISSISGRDDL----MDYHRRQREER----------------- 436
            L+  SG     L E++  IS +S    L    ++  RRQ EE                  
Sbjct: 1329 LQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHD 1388

Query: 437  ---LREQEMERLERQ-RLETILSLC-AEYTKPDSRLSTGTT--VEDVQKINKELEKLQLS 489
               LREQ  E  E Q  L+ +LS   AE  +  S+         E++++  K+L  L+L 
Sbjct: 1389 CDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLA-LRLQ 1447

Query: 490  DEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTR 549
            + E   E A     +  +   +      D+      + S+A+    +    +  L +  R
Sbjct: 1448 EAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRR 1507

Query: 550  TPPPPSSTFPKASSESSYLSI-LPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKI 608
                       A  ES  L   L +   G  E   + E    E        NL+E    +
Sbjct: 1508 QEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKREN------KNLQEEISDL 1561

Query: 609  KDINDQMDESFRELDMECALLDGEQKSETTELMKEKE-ILDHLNRKIAELEKNIVGEKTK 667
             D      +S +EL+     L+GE KSE    ++E E  L+    K   ++  +   K +
Sbjct: 1562 TDQVSLSGKSIQELEKTKKALEGE-KSEIQAALEEAEGALELEETKTLRIQLELSQVKAE 1620

Query: 668  EKVKLDAEREKLERL----QELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFE 723
               KL  + E+   L    Q      +  LD    +  E L+ + K + DL D+E     
Sbjct: 1621 VDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLE----- 1675

Query: 724  DLEFQQLEHESRLDEEKENLTQ----QLLREVA---EYQRNIVSRKEKISALKKQANHIV 776
                 QL H +R   E +  T+    QL  E A   E QR      E+  AL+++A+ + 
Sbjct: 1676 ----LQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLA 1731

Query: 777  -------------QQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810
                         ++++R  +  + E    + +L  +   L N +KK
Sbjct: 1732 AELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKK 1778



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 38/172 (22%), Positives = 79/172 (45%), Gaps = 14/172 (8%)

Query: 652  RKIAELEKNIVGEKTKEKVKLDAEREKLERLQE---LYSEQKTQLDNCPESMREQLQQQL 708
            +++ E   +I  EK    ++L AE++ L   +E   L  + K QL+   + + E+L+ + 
Sbjct: 920  QELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEE 979

Query: 709  KRDADL------LDVE----SKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI 758
            + +ADL      L+ E     K  +DL+    + E    +  EN  + L  E+A    ++
Sbjct: 980  EVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKE-KQATENKVKNLTEEMAALDESV 1038

Query: 759  VSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810
                ++  AL++     +   Q E+D         + + Q+ ++  C+LE++
Sbjct: 1039 ARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQE 1090



 Score = 39.3 bits (90), Expect = 0.024
 Identities = 76/363 (20%), Positives = 141/363 (38%), Gaps = 45/363 (12%)

Query: 372  ESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRR 431
            E D   A  R     +VE  +A L++  +A      ALR +K     ++  +  + +  R
Sbjct: 1627 EKDEECANLRRNHQRAVESLQASLDAETRARNE---ALRLKKKMEGDLNDLELQLGHATR 1683

Query: 432  QREE----------RLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINK 481
            Q  E          +L+E++  R E QRL   L   A+  +  + L     +E+++   +
Sbjct: 1684 QATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASL-LAAELEELRAALE 1742

Query: 482  ELEKLQLSDEESVFEEA----LMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRS 537
            + E+ +   E+ + E      L+        ++K  L +ADLA      + +A       
Sbjct: 1743 QGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKL-EADLAQLSGEVEEAAQERREAE 1801

Query: 538  TRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVI 597
             +  + ++D        +    K    S++L  + KT E    E +    A +EE     
Sbjct: 1802 EKAKKAITDAAMM----AEELKKEQDTSAHLERMKKTLEQTVRELQ----ARLEEAEQAA 1853

Query: 598  LNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAEL 657
            L   ++  QK+       +   REL+ E   LD EQK     L   K +  H  R     
Sbjct: 1854 LRGGKKQVQKL-------EAKVRELEAE---LDAEQKKHAEAL---KGVRKHERRV---- 1896

Query: 658  EKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV 717
             K +  +  +++  L   ++ +++LQ      K Q +   +     L +  K   +L D 
Sbjct: 1897 -KELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDA 1955

Query: 718  ESK 720
            E +
Sbjct: 1956 EER 1958



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 25/105 (23%), Positives = 57/105 (54%), Gaps = 8/105 (7%)

Query: 1026 SASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRA---LEEEKRRREI---LEK 1079
            +A   ++AR+ + ++ L++AH +    L++ E  + A  +A   LE++    E     EK
Sbjct: 1032 AALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEK 1091

Query: 1080 RLQEETSQRQKLIEKEVKIRERQRAQARPLTRYL--PVRKEDFDL 1122
            +L+ +T + ++ +E ++K+ +   A A    + L   ++K+D +L
Sbjct: 1092 KLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSEL 1136


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 73/393 (18%), Positives = 167/393 (42%), Gaps = 26/393 (6%)

Query: 431  RQREERLREQEMERLERQRLETILSLCAEYTKPD---SRLSTGTTVEDVQKINKELEKLQ 487
            ++ EE++   E E  E++     + L A   K +   SR  T T  E+++ +  E ++L 
Sbjct: 947  KELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLS 1006

Query: 488  LSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDL 547
             S  + + + A    +      ++    D +     +           R  RN  L  + 
Sbjct: 1007 ASMRDLI-QGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDL--TRQLRNSTLQCET 1063

Query: 548  TRTPPPPS-STFPKASSESSYLSI----LPKTPEGISEEQRSQELAAMEETR--IVILNN 600
              +      +      S +  L +    + +    + +E  +++L   ++ +     +N 
Sbjct: 1064 INSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123

Query: 601  LEELKQKIKDINDQMDESFREL-----DMECALLDGEQKSETTELMKE-KEILDHLNRKI 654
            LEEL+ +++    Q+ ++ +EL     D +   L   + ++   LMKE  + L + N KI
Sbjct: 1124 LEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKI 1183

Query: 655  AELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADL 714
             +LE+ I  +K K++  L  E   L+   + Y E+ T++       +++L    + + D 
Sbjct: 1184 EDLEQEIKIQKQKQET-LQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDH 1242

Query: 715  LDVESKHFEDLEFQQLEHE------SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISAL 768
            L +++    +LE  Q + E      + +  EK  + + L     ++QR + + +++++AL
Sbjct: 1243 LILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTAL 1302

Query: 769  KKQANHIVQQAQREQDHFVKEKNNLIMMLQREK 801
            +++      +       F   K  +  +L+++K
Sbjct: 1303 QEECRAAKAEQATVTSEFESYKVRVHNVLKQQK 1335



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 76/304 (25%), Positives = 130/304 (42%), Gaps = 43/304 (14%)

Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
           ++L+ D   +P  P +         S L  LPK  + I   ++   L    ++R   L  
Sbjct: 2   EDLVQDGVASPATPGTG-------KSKLETLPKE-DLIKFAKKQMMLIQKAKSRCTELEK 53

Query: 601 -LEELKQK-----IKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKI 654
            +EEL+ K       DI   + E    L +E A  + +  S   E +K K+ ++    K+
Sbjct: 54  EIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKM 113

Query: 655 AELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDN-CPESMREQLQ--QQLKRD 711
            +  K +         +++  + +L  ++  YSE K  L     E+M  QL+  +QLK  
Sbjct: 114 GDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQ 173

Query: 712 ADLLDVESKHFEDLE-----------FQQLEHESRLDEEKENLTQQLLREVAE-----YQ 755
            +  D   K  E++E           + Q + ++  DE+KE +TQ  L+ + E     YQ
Sbjct: 174 NNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQ--LQNIIEANSQHYQ 231

Query: 756 RNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLC--------NL 807
           +NI S +E++  LK      V++   + +   KE    I  L   KENL         N+
Sbjct: 232 KNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNI 291

Query: 808 EKKY 811
           +KKY
Sbjct: 292 QKKY 295



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 159/803 (19%), Positives = 306/803 (38%), Gaps = 178/803 (22%)

Query: 426  MDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEK 485
            ++ H R+ +  L+EQ  + +     ET LS        DS     T + ++Q + ++ E 
Sbjct: 419  VEQHNREVQS-LKEQHQKEISELN-ETFLS--------DSEKEKLTLMFEIQGLKEQCEN 468

Query: 486  LQLSDEESVFE-----------EALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFT 534
            LQ   +E++             +  +           +S+     +    L Q   + FT
Sbjct: 469  LQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFT 528

Query: 535  PRST----------RNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS 584
             +             N++LLS     P   ++          YL         +S  QR 
Sbjct: 529  EKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYL---------LSLSQRD 579

Query: 585  QELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALL--------------- 629
              L  +E     +    ++   K+K+ +++MD   ++ + E  L+               
Sbjct: 580  TMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNS 639

Query: 630  DGEQK-SETT----ELMKEKEILDH------LNRKIAELEKNIVGEKTK----EKVKLDA 674
            + EQK +E T    E +KEK+  D       +  K+   +K ++  + K    E  KL +
Sbjct: 640  ELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSS 699

Query: 675  EREKLERLQELYSEQK---------TQLDNCPESMREQ---LQQQLKRD----------- 711
            E+++L R  E++  QK         TQL+   + M E+   L + L+ +           
Sbjct: 700  EKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQL 759

Query: 712  -ADLLDVESKHFEDLEFQQL--------EHESRLDEEKENLTQQLLREVAEYQRNIVSRK 762
               L ++ S+  ED E + +        E  ++++EEK NL  Q   +V E ++ I   +
Sbjct: 760  YGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQ 819

Query: 763  EKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCN--LEKKYSSLSGGKGF 820
            E+     ++   +++  ++E+    KE    +  +Q EKE L +  LE K ++    K  
Sbjct: 820  EESVVQCEELKSLLRDYEQEKVLLRKE----LEEIQSEKEALQSDLLEMKNAN---EKTR 872

Query: 821  PVNPNTLKEGYISVNEINEPCGNS--------------TNLSP----------STQFPAD 856
              N N L    I V E+++ C  S               NL P            +    
Sbjct: 873  LENQNLL----IQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILL 928

Query: 857  ADAVATEPATA--VLASQPQSKEHFRSLEERKKQHKE---GLYLSDTLPRKKTTSSISPH 911
             D++A  P+     L+S  + +E   +LE+  K+ +E    + L     +K+  SS    
Sbjct: 929  KDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSS---- 984

Query: 912  FSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSES-RRMLRGYNHQ--QMSEGH 968
                   R  T      L    S    L  S+  + + +ES + +L  Y  Q  Q+    
Sbjct: 985  -------RKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEK 1037

Query: 969  RQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSAS 1028
             + + F +R    +    NS             +T++ D+ D +    +  S   +    
Sbjct: 1038 ERANNFEHRIEDLTRQLRNS---------TLQCETINSDNEDLLARIETLQSNAKLLEVQ 1088

Query: 1029 TSNIARIE-------EMERLLKQ----AHAEKTRLLESREREMEAKKRALEEEKRRREIL 1077
               + R +       E E+L K+     HA     LE  + +++ +K+ L++  +  E++
Sbjct: 1089 ILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELV 1148

Query: 1078 EKRLQEETSQRQKLIEKEVKIRE 1100
            +K  Q+ T    ++ + E  ++E
Sbjct: 1149 KKDAQQTTLMNMEIADYERLMKE 1171



 Score = 35.0 bits (79), Expect = 0.45
 Identities = 33/137 (24%), Positives = 58/137 (42%), Gaps = 4/137 (2%)

Query: 959  YNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISA 1018
            Y  +Q+     +K E    T  ++ +  NS HY  +    Q  + L L +    E     
Sbjct: 200  YLQKQLDATTDEKKETV--TQLQNIIEANSQHYQKNINSLQE-ELLQLKAIHQEEVKELM 256

Query: 1019 CSPDNISSASTSNIARIEEM-ERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREIL 1077
            C  +  +    + I ++ E+ E L+KQ  A +  + +  E E+E  ++A     +  +I 
Sbjct: 257  CQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQIC 316

Query: 1078 EKRLQEETSQRQKLIEK 1094
               LQE T   Q + EK
Sbjct: 317  SILLQENTFVEQVVNEK 333


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 66/259 (25%), Positives = 125/259 (48%), Gaps = 28/259 (10%)

Query: 576 EGISEEQRSQELAAM--EETRI----VILNNLEELKQKIKDINDQMDESFRELDMECALL 629
           E I EE++ QE   M  +E +I     I    E++ ++ + I  Q ++ +R+   E  + 
Sbjct: 464 EKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQ---EEKIR 520

Query: 630 DGEQKSETTE--LMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYS 687
           + E+K    E  + +++E +        E EK    EK  E+ K   + +K+ R +E   
Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIR 580

Query: 688 EQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLE-FQQLEHESRLDEEK----EN 742
           EQ+ ++    E +REQ +++ +++  +   E K  E  E  Q+ E + R  EEK    E 
Sbjct: 581 EQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEE 640

Query: 743 LTQQLLREVAEYQRNIVSRKEKI----SALKKQANHIVQQAQ--REQDHFVKEKNNLIMM 796
           +TQ+   ++ E +  +  ++EK+      + +Q   I +Q +  REQ+  ++E+  + M 
Sbjct: 641 MTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEM-MQ 699

Query: 797 LQREK-----ENLCNLEKK 810
            Q EK     E +C  E+K
Sbjct: 700 EQEEKMWEQEEKMCEQEEK 718



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 51/270 (18%), Positives = 119/270 (44%), Gaps = 33/270 (12%)

Query: 574 TPEGISEEQRS--QELAAMEETRIVILNNLEELKQKIK---------DINDQMDESFREL 622
           T E + E+     ++L  +E  +  I  N++ELK+K++          +  + D   +EL
Sbjct: 215 TDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL 274

Query: 623 DMECALLDGE----------QKSETTELMKEKEILDHLNRKIAELEKNI---------VG 663
               A L  +           + +  ++ +++E +     KI E E+ I           
Sbjct: 275 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE 334

Query: 664 EKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFE 723
           EK + + ++  E+E+  R QE    +K +     E M  + +++++R  +++  + +   
Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 394

Query: 724 DLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQR-- 781
           +LE +  E E   ++E++   ++ +RE  + Q        +   +++Q   I +Q ++  
Sbjct: 395 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMW 454

Query: 782 EQDHFVKEKNNLIMMLQR-EKENLCNLEKK 810
            Q+  + E+  +    +R E+E +   E+K
Sbjct: 455 RQEEKIHEQEKIREEEKRQEQEEMWRQEEK 484



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 30/148 (20%), Positives = 75/148 (50%), Gaps = 5/148 (3%)

Query: 602 EELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNI 661
           EE +Q+ ++   + +E  RE + +    + + + +  ++ +++E+      K+ E E+ +
Sbjct: 597 EEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKM 656

Query: 662 VGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKH 721
                +++ K+  + E + R +E   EQ+ ++    E +REQ +   +++  + + E K 
Sbjct: 657 C----EQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 712

Query: 722 FEDLEFQQLEHESRLDEEKENLTQQLLR 749
            E  E  Q E E ++  ++E + +Q +R
Sbjct: 713 CEQEEKMQ-EQEEKMRRQEEKMWEQEVR 739



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 45/235 (19%), Positives = 107/235 (45%), Gaps = 21/235 (8%)

Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELM 641
           +R +E+   +E +I  L      ++KI++  ++  E  +  + E      +++ +  ++ 
Sbjct: 380 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE------KRQEQEAKMW 433

Query: 642 KEKEILDHLNRKIAELEKNIVGEKTK----EKVKLDAEREKLERL--QELYSEQKTQLDN 695
           +++E +     KI E EK +  ++ K    EK++ + +R++ E +  QE    ++ ++  
Sbjct: 434 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWR 493

Query: 696 CPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQ 755
             E M EQ ++  K++  +   E K       ++ E + R  EEK    ++ +RE  E  
Sbjct: 494 QKEKMHEQEEKIRKQEEKVWRQEEK------IREQEEKIREQEEKMWRQEEKIREQEEMW 547

Query: 756 RNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810
           R      E+    +++     +     Q+  ++E+   +    R++E +   E+K
Sbjct: 548 REEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVW---RQEEKIREQEEK 599



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 49/234 (20%), Positives = 102/234 (43%), Gaps = 46/234 (19%)

Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELM 641
           ++ +++   EE    ++   EE  ++ +++  + +E  REL         E+K    E +
Sbjct: 360 EKEEKMRRQEE----MMWEKEEKMRRQEEMMWEKEEKIREL---------EEKMHEQEKI 406

Query: 642 KEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMR 701
           +E+E            EK    EK +E+ K   +  K+ R +E   EQ+       E +R
Sbjct: 407 REQE------------EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE-------EKIR 447

Query: 702 EQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSR 761
           EQ ++  +++  + + E            E E R ++E+    ++ + E  E  R     
Sbjct: 448 EQEKKMWRQEEKIHEQEKIR---------EEEKRQEQEEMWRQEEKIHEQEEIWRQKEKM 498

Query: 762 KEKISALKKQANHIVQQAQ--REQDHFVKEKNNLIMMLQ---REKENLCNLEKK 810
            E+   ++KQ   + +Q +  REQ+  ++E+   +   +   RE+E +   E+K
Sbjct: 499 HEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEK 552



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 36/151 (23%), Positives = 72/151 (47%), Gaps = 11/151 (7%)

Query: 580 EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRE---LDMECALLDGEQKSE 636
           EE+R ++   M +    I    E+++++ + I +Q +E  RE   +  E     GEQ+ +
Sbjct: 597 EEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQ-EEKIREQEEMTQEQEEKMGEQEEK 655

Query: 637 TTE----LMKEKEILDHLNRKIAELEKNIVGEKTK---EKVKLDAEREKLERLQELYSEQ 689
             E    + +++E +     KI E EK I  ++ K   ++  +  + EK+   +E   EQ
Sbjct: 656 MCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 715

Query: 690 KTQLDNCPESMREQLQQQLKRDADLLDVESK 720
           + ++    E MR Q ++  +++  L   E K
Sbjct: 716 EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 25/79 (31%), Positives = 43/79 (54%), Gaps = 7/79 (8%)

Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREIL----EKRLQEETS---QR 1088
            E+M R  +    ++ ++ E  E+  E +K   +EEKR+ E      EKR ++E     Q 
Sbjct: 377  EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 436

Query: 1089 QKLIEKEVKIRERQRAQAR 1107
            +K+ E+E KIRE+++   R
Sbjct: 437  EKIREQEEKIREQEKKMWR 455



 Score = 35.4 bits (80), Expect = 0.34
 Identities = 25/82 (30%), Positives = 46/82 (56%), Gaps = 3/82 (3%)

Query: 1024 ISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQ 1082
            + S S    A++EE E   +    ++ ++    E+  E +++  E+E++ RE  EK R Q
Sbjct: 274  LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333

Query: 1083 EETSQRQK--LIEKEVKIRERQ 1102
            EE  +RQ+  + EKE K+R ++
Sbjct: 334  EEKMRRQEEMMWEKEEKMRRQE 355



 Score = 35.0 bits (79), Expect = 0.45
 Identities = 46/252 (18%), Positives = 103/252 (40%), Gaps = 26/252 (10%)

Query: 653 KIAELEKNIVGE--KTKEKVKLDAEREKLERLQELYSEQKTQLDNC--PESMRE---QLQ 705
           K+AE ++ +     +T   V   A   K +++    + + T    C  PE  ++   Q Q
Sbjct: 59  KLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQKASHQHQ 118

Query: 706 QQLKRDAD-------LLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI 758
           + L+R+ +       +L  +    +   +       +L+ E  +L  +L  +  ++   +
Sbjct: 119 EALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL-HDSWKFAGEL 177

Query: 759 VSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGK 818
                 ++  KK+A+  +++  +E+D    E     +  +  KE    L++K   +   K
Sbjct: 178 EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEK 237

Query: 819 GFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATE--PATAVLASQPQSK 876
                     E  ++V E+      +  L P  Q  A+AD +  E    +A L +Q +  
Sbjct: 238 ---------SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 288

Query: 877 EHFRSLEERKKQ 888
           E +  L +++++
Sbjct: 289 ELWNRLNQQQEE 300



 Score = 34.7 bits (78), Expect = 0.59
 Identities = 26/71 (36%), Positives = 41/71 (57%), Gaps = 4/71 (5%)

Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQ--KL 1091
            +I+E E  +++   EK R  E   +E E +K   +EEK   +  + + QEET  RQ  K+
Sbjct: 620  KIQEQEEKIREQE-EKIREQEEMTQEQE-EKMGEQEEKMCEQEEKMQEQEETMWRQEEKI 677

Query: 1092 IEKEVKIRERQ 1102
             E+E KIRE++
Sbjct: 678  REQEKKIREQE 688



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 26/77 (33%), Positives = 41/77 (53%), Gaps = 9/77 (11%)

Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEE------EKRRR--EILEKRLQEET 1085
            +I+E E  + Q   EK R  E + RE E K R  EE      EK RR  E++ ++ ++  
Sbjct: 308  KIQEWEEKI-QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366

Query: 1086 SQRQKLIEKEVKIRERQ 1102
             Q + + EKE K+R ++
Sbjct: 367  RQEEMMWEKEEKMRRQE 383



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 24/67 (35%), Positives = 40/67 (59%), Gaps = 8/67 (11%)

Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKE 1095
            E+ E++ +Q   EK R  E + +E E K    EE+ R +E   +++QE   Q +K+ E+E
Sbjct: 581  EQEEKVWRQE--EKIREQEEKRQEQEEKMWKQEEKIREQE---EKIQE---QEEKIREQE 632

Query: 1096 VKIRERQ 1102
             KIRE++
Sbjct: 633  EKIREQE 639



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 30/126 (23%), Positives = 59/126 (46%), Gaps = 26/126 (20%)

Query: 577 GISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSE 636
           G  EE+  ++   M+E    +    E+++++ K I +Q +E  RE +             
Sbjct: 650 GEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQ-EEKIREQE------------- 695

Query: 637 TTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNC 696
             E+M+E+E       K+ E E+ +     +++ K+  + EK+ R +E   EQ+ +L   
Sbjct: 696 --EMMQEQE------EKMWEQEEKMC----EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 743

Query: 697 PESMRE 702
            E M+E
Sbjct: 744 EEKMQE 749



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 23/72 (31%), Positives = 40/72 (55%), Gaps = 3/72 (4%)

Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIE 1093
            +I E E   K+   EK R  E R+ E EAK    EE+ R +E   +  +++  ++++ I 
Sbjct: 405  KIREQEE--KRQEEEKIREQEKRQ-EQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH 461

Query: 1094 KEVKIRERQRAQ 1105
            ++ KIRE ++ Q
Sbjct: 462  EQEKIREEEKRQ 473



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 21/72 (29%), Positives = 45/72 (62%), Gaps = 6/72 (8%)

Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQEETSQRQ--K 1090
            +I E E+ +++   ++ ++ E  E   E +++  E+E++  E  EK + QEE  +RQ  K
Sbjct: 676  KIREQEKKIRE---QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 732

Query: 1091 LIEKEVKIRERQ 1102
            + E+EV++R+++
Sbjct: 733  MWEQEVRLRQQE 744



 Score = 32.7 bits (73), Expect = 2.2
 Identities = 16/70 (22%), Positives = 43/70 (61%), Gaps = 2/70 (2%)

Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK--RLQEETSQRQKLIE 1093
            EE+ R  ++ H ++ ++ +  E+    +++  E+E++ RE  EK  R +E+  +++++  
Sbjct: 489  EEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR 548

Query: 1094 KEVKIRERQR 1103
            +E K+ E+++
Sbjct: 549  EEEKMHEQEK 558



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 25/97 (25%), Positives = 49/97 (50%), Gaps = 6/97 (6%)

Query: 1034 RIEEMERLLKQAHAEKTRLLES---REREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1090
            +I E E  +++   +  R  E    +E+  E +KR  +EE  R+E      +E   Q++K
Sbjct: 438  KIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEK 497

Query: 1091 LIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVE 1127
            + E+E KIR+++    R   +   +R+++  +R   E
Sbjct: 498  MHEQEEKIRKQEEKVWRQEEK---IREQEEKIREQEE 531



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 26/71 (36%), Positives = 40/71 (56%), Gaps = 5/71 (7%)

Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQEETSQRQKLIEK 1094
            E+ E++ KQ   EK    E + RE E K R  EE+  R+E  EK R QEE  + ++ + +
Sbjct: 500  EQEEKIRKQE--EKVWRQEEKIREQEEKIREQEEKMWRQE--EKIREQEEMWREEEKMHE 555

Query: 1095 EVKIRERQRAQ 1105
            + KI E ++ Q
Sbjct: 556  QEKIWEEEKRQ 566



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 32/104 (30%), Positives = 51/104 (49%), Gaps = 16/104 (15%)

Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQEETSQRQ--- 1089
            +I E E   +Q   EK    E + RE E K +  EE+ R +E  EK R QEE +Q Q   
Sbjct: 592  KIREQEEK-RQEQEEKMWKQEEKIREQEEKIQEQEEKIREQE--EKIREQEEMTQEQEEK 648

Query: 1090 ------KLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVE 1127
                  K+ E+E K++E++    R   +   +R+++  +R   E
Sbjct: 649  MGEQEEKMCEQEEKMQEQEETMWRQEEK---IREQEKKIREQEE 689



 Score = 32.0 bits (71), Expect = 3.8
 Identities = 21/76 (27%), Positives = 42/76 (55%), Gaps = 10/76 (13%)

Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEK---------RRREILEKRLQEETS 1086
            EEM R  ++ H E+ ++ E  +R+ +  K   +EEK         R+ E + ++ ++   
Sbjct: 544  EEMWREEEKMH-EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQE 602

Query: 1087 QRQKLIEKEVKIRERQ 1102
            Q +K+ ++E KIRE++
Sbjct: 603  QEEKMWKQEEKIREQE 618



 Score = 31.6 bits (70), Expect = 5.0
 Identities = 26/75 (34%), Positives = 38/75 (50%), Gaps = 9/75 (12%)

Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEE------EKRRR--EILEKRLQEET 1085
            +I E E  +++   EK R  E    E E K R  EE      EK RR  E++ ++ ++  
Sbjct: 322  KIREQEEKIREQE-EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 380

Query: 1086 SQRQKLIEKEVKIRE 1100
             Q + + EKE KIRE
Sbjct: 381  RQEEMMWEKEEKIRE 395



 Score = 31.6 bits (70), Expect = 5.0
 Identities = 23/64 (35%), Positives = 36/64 (56%), Gaps = 6/64 (9%)

Query: 1048 EKTRLLESREREMEAKKRALEE-----EKRRREILEK-RLQEETSQRQKLIEKEVKIRER 1101
            EK R  E    E E K R  EE     E++ RE+ EK   QE+  ++++  ++E KIRE+
Sbjct: 363  EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 422

Query: 1102 QRAQ 1105
            ++ Q
Sbjct: 423  EKRQ 426



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 21/77 (27%), Positives = 42/77 (54%), Gaps = 3/77 (3%)

Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQEETSQRQ--K 1090
            +I E E++ ++   ++   +  +E ++  ++    ++++  E  EK R QEE   RQ  K
Sbjct: 459  KIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEK 518

Query: 1091 LIEKEVKIRERQRAQAR 1107
            + E+E KIRE++    R
Sbjct: 519  IREQEEKIREQEEKMWR 535



 Score = 30.8 bits (68), Expect = 8.5
 Identities = 24/82 (29%), Positives = 42/82 (51%), Gaps = 14/82 (17%)

Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQEETSQRQ----- 1089
            E+ E++ +Q    + ++ E  E     +++  E+EK+ RE  EK R QEE  Q Q     
Sbjct: 651  EQEEKMCEQ----EEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 706

Query: 1090 ----KLIEKEVKIRERQRAQAR 1107
                K+ E+E K++E++    R
Sbjct: 707  EQEEKMCEQEEKMQEQEEKMRR 728


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.126    0.347 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,573,611
Number of Sequences: 37866
Number of extensions: 2376058
Number of successful extensions: 24724
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 328
Number of HSP's successfully gapped in prelim test: 1108
Number of HSP's that attempted gapping in prelim test: 12257
Number of HSP's gapped (non-prelim): 9512
length of query: 1253
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1139
effective length of database: 13,930,794
effective search space: 15867174366
effective search space used: 15867174366
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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