BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|197313732 pleckstrin homology-like domain, family B, member 2 isoform a [Homo sapiens] (1253 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|197313732 pleckstrin homology-like domain, family B, member 2... 2467 0.0 gi|197313730 pleckstrin homology-like domain, family B, member 2... 2467 0.0 gi|197313728 pleckstrin homology-like domain, family B, member 2... 2364 0.0 gi|21955172 pleckstrin homology-like domain, family B, member 2 ... 2364 0.0 gi|221219026 pleckstrin homology-like domain, family B, member 1... 625 e-179 gi|221219024 pleckstrin homology-like domain, family B, member 1... 620 e-177 gi|38424073 pleckstrin homology-like domain, family B, member 1 ... 620 e-177 gi|157266264 pleckstrin homology-like domain, family B, member 3... 201 5e-51 gi|21735548 centrosomal protein 2 [Homo sapiens] 67 1e-10 gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 67 1e-10 gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 66 2e-10 gi|115511012 coiled-coil domain containing 136 [Homo sapiens] 66 2e-10 gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 65 3e-10 gi|41872583 Rho-associated, coiled-coil containing protein kinas... 65 4e-10 gi|71061468 centromere protein E [Homo sapiens] 65 4e-10 gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 64 7e-10 gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom... 64 7e-10 gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 64 1e-09 gi|38044112 restin isoform b [Homo sapiens] 62 3e-09 gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 62 3e-09 gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 62 4e-09 gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 62 4e-09 gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 61 6e-09 gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 61 6e-09 gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 61 6e-09 gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 61 6e-09 gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 61 6e-09 gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 60 1e-08 gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 60 1e-08 gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 60 2e-08 >gi|197313732 pleckstrin homology-like domain, family B, member 2 isoform a [Homo sapiens] Length = 1253 Score = 2467 bits (6395), Expect = 0.0 Identities = 1253/1253 (100%), Positives = 1253/1253 (100%) Query: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL Sbjct: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60 Query: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG Sbjct: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120 Query: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW Sbjct: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180 Query: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK Sbjct: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240 Query: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN Sbjct: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300 Query: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV Sbjct: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360 Query: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS Sbjct: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420 Query: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN Sbjct: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480 Query: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN Sbjct: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540 Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN Sbjct: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600 Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN Sbjct: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660 Query: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK Sbjct: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720 Query: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ Sbjct: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780 Query: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP Sbjct: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840 Query: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP Sbjct: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900 Query: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN Sbjct: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960 Query: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS Sbjct: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020 Query: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR Sbjct: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080 Query: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS Sbjct: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140 Query: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD Sbjct: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200 Query: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL Sbjct: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253 >gi|197313730 pleckstrin homology-like domain, family B, member 2 isoform a [Homo sapiens] Length = 1253 Score = 2467 bits (6395), Expect = 0.0 Identities = 1253/1253 (100%), Positives = 1253/1253 (100%) Query: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL Sbjct: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60 Query: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG Sbjct: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120 Query: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW Sbjct: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180 Query: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK Sbjct: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240 Query: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN Sbjct: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300 Query: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV Sbjct: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360 Query: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS Sbjct: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420 Query: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN Sbjct: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480 Query: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN Sbjct: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540 Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN Sbjct: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600 Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN Sbjct: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660 Query: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK Sbjct: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720 Query: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ Sbjct: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780 Query: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP Sbjct: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840 Query: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP Sbjct: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900 Query: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN Sbjct: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960 Query: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS Sbjct: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020 Query: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR Sbjct: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080 Query: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS Sbjct: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140 Query: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD Sbjct: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200 Query: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL Sbjct: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253 >gi|197313728 pleckstrin homology-like domain, family B, member 2 isoform b [Homo sapiens] Length = 1237 Score = 2364 bits (6126), Expect = 0.0 Identities = 1210/1253 (96%), Positives = 1210/1253 (96%), Gaps = 43/1253 (3%) Query: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL Sbjct: 28 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 87 Query: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG Sbjct: 88 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 147 Query: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW Sbjct: 148 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 207 Query: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK Sbjct: 208 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 267 Query: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN Sbjct: 268 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 327 Query: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV Sbjct: 328 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 387 Query: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS Sbjct: 388 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 447 Query: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN Sbjct: 448 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 507 Query: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN Sbjct: 508 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 567 Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN Sbjct: 568 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 627 Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN Sbjct: 628 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 687 Query: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720 IVGEKTK DADLLDVESK Sbjct: 688 IVGEKTK-------------------------------------------DADLLDVESK 704 Query: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ Sbjct: 705 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764 Query: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP Sbjct: 765 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 824 Query: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP Sbjct: 825 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 884 Query: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN Sbjct: 885 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 944 Query: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS Sbjct: 945 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1004 Query: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR Sbjct: 1005 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1064 Query: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS Sbjct: 1065 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1124 Query: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD Sbjct: 1125 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1184 Query: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL Sbjct: 1185 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1237 >gi|21955172 pleckstrin homology-like domain, family B, member 2 isoform c [Homo sapiens] Length = 1210 Score = 2364 bits (6126), Expect = 0.0 Identities = 1210/1253 (96%), Positives = 1210/1253 (96%), Gaps = 43/1253 (3%) Query: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL Sbjct: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60 Query: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG Sbjct: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120 Query: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW Sbjct: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180 Query: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK Sbjct: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240 Query: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN Sbjct: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300 Query: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV Sbjct: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360 Query: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS Sbjct: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420 Query: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN Sbjct: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480 Query: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN Sbjct: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540 Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN Sbjct: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600 Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN Sbjct: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660 Query: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720 IVGEKTK DADLLDVESK Sbjct: 661 IVGEKTK-------------------------------------------DADLLDVESK 677 Query: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ Sbjct: 678 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 737 Query: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP Sbjct: 738 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 797 Query: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP Sbjct: 798 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 857 Query: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN Sbjct: 858 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 917 Query: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS Sbjct: 918 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 977 Query: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR Sbjct: 978 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1037 Query: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS Sbjct: 1038 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1097 Query: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD Sbjct: 1098 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1157 Query: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL Sbjct: 1158 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1210 >gi|221219026 pleckstrin homology-like domain, family B, member 1 isoform b [Homo sapiens] Length = 1319 Score = 625 bits (1612), Expect = e-179 Identities = 386/881 (43%), Positives = 513/881 (58%), Gaps = 167/881 (18%) Query: 407 PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 465 P RERK+SI+ IS DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D Sbjct: 570 PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629 Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525 G ++ I + L L+ P LA Sbjct: 630 ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663 Query: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585 S T R + E SD SST S++ + E + Sbjct: 664 SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711 Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645 E+ A+EE R +L ++E+LK ++K++ Q+ ES RE +ME ALL G Sbjct: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQG-------------- 757 Query: 646 ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQ 705 E+ E+ L E++ +++LQE +T + Q Sbjct: 758 ------------------EREAERALLQKEQKAVDQLQEKLVALETGI-----------Q 788 Query: 706 QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765 ++ ++A+ L+ E+K FEDLEFQQLE ESR++EE+E Q LLR AE R+I RKE++ Sbjct: 789 KERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERL 848 Query: 766 SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPN 825 + L QA I QA +E + ++KN + +LQ+EKE L LE++Y SL+GG+ FP + Sbjct: 849 AILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTS 908 Query: 826 TLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEER 885 TLKE Y S + G +T+ P T+ Sbjct: 909 TLKEVYRSKMD-----GEATSPLPRTR--------------------------------- 930 Query: 886 KKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAA 945 S LP +SS S S AT+GRS +PK+ L N GS LP +LAA Sbjct: 931 ----------SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLT--QNGTGS-LPRNLAA 977 Query: 946 MAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFH-----------YP 992 +D E++R L + Q + E R+ +E + A+E+ ++ H +P Sbjct: 978 TLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFP 1037 Query: 993 D---HSYK-------------DQAFDTLSLDSSDSMETSIS-----ACSPDNISSASTSN 1031 HS + A+DTLSL+SSDSMETSIS ACSPDN+SSAS + Sbjct: 1038 PLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLD 1097 Query: 1032 IARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKL 1091 + +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RRRE +E+RLQ E+++RQ+L Sbjct: 1098 MGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQL 1157 Query: 1092 IEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLI 1151 +EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +DTC HV ++ K CRG+L+ Sbjct: 1158 VEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLV 1217 Query: 1152 KMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNP 1211 KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQAIEEVYYDHL++A KSPNP Sbjct: 1218 KMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNP 1277 Query: 1212 LLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFL 1252 LTF VKTHDR+YYMVAPS EAMRIWMDVIVTGAEGYT F+ Sbjct: 1278 ALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFM 1318 >gi|221219024 pleckstrin homology-like domain, family B, member 1 isoform a [Homo sapiens] Length = 1377 Score = 620 bits (1600), Expect = e-177 Identities = 388/893 (43%), Positives = 524/893 (58%), Gaps = 133/893 (14%) Query: 407 PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 465 P RERK+SI+ IS DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D Sbjct: 570 PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629 Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525 G ++ I + L L+ P LA Sbjct: 630 ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663 Query: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585 S T R + E SD SST S++ + E + Sbjct: 664 SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711 Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645 E+ A+EE R +L ++E+LK ++K++ Q+ ES RE +ME ALL G Sbjct: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQG-------------- 757 Query: 646 ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQ 705 E+ E+ L E++ +++LQE +T + Q Sbjct: 758 ------------------EREAERALLQKEQKAVDQLQEKLVALETGI-----------Q 788 Query: 706 QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765 ++ ++A+ L+ E+K FEDLEFQQLE ESR++EE+E Q LLR AE R+I RKE++ Sbjct: 789 KERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERL 848 Query: 766 SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPN 825 + L QA I QA +E + ++KN + +LQ+EKE L LE++Y SL+GG+ FP + Sbjct: 849 AILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTS 908 Query: 826 TLKE-GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEE 884 TLKE + + ++ ++ PA A ++ P AS+ + +RS + Sbjct: 909 TLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASR--QLQVYRSKMD 966 Query: 885 RKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLA 944 + S LP +SS S S AT+GRS +PK+ L N GS LP +LA Sbjct: 967 GEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLT--QNGTGS-LPRNLA 1023 Query: 945 AMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFH-----------Y 991 A +D E++R L + Q + E R+ +E + A+E+ ++ H + Sbjct: 1024 ATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGF 1083 Query: 992 PD---HSYK-------------DQAFDTLSLDSSDSMETSIS-----ACSPDNISSASTS 1030 P HS + A+DTLSL+SSDSMETSIS ACSPDN+SSAS Sbjct: 1084 PPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGL 1143 Query: 1031 NIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1090 ++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RRRE +E+RLQ E+++RQ+ Sbjct: 1144 DMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQ 1203 Query: 1091 LIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFL 1150 L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +DTC HV ++ K CRG+L Sbjct: 1204 LVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYL 1263 Query: 1151 IKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANK--- 1207 +KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQAIEEVYYDHL++A K Sbjct: 1264 VKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRF 1323 Query: 1208 --------SPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFL 1252 SPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIVTGAEGYT F+ Sbjct: 1324 FRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFM 1376 Score = 34.3 bits (77), Expect = 0.77 Identities = 91/427 (21%), Positives = 157/427 (36%), Gaps = 59/427 (13%) Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLERQR 449 E+ +E R+ +G Q LR + + SI+ R + + Q + + QE ERL R + Sbjct: 816 ESRVEEERELAG--QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDK 873 Query: 450 LETILSLCAEYTKPD------SRLSTGTTVEDVQKINKELEKLQLS--DEESVFEEALMS 501 ++ L E K L+ G KE+EKL L D E ++E + Sbjct: 874 NASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAG 933 Query: 502 PDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDL--TRTPPPPSSTFP 559 T S P A ++S RS + E S L TR+ P PSS+ Sbjct: 934 LGTGPAAASPHSSPPPLPA------KASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGS 987 Query: 560 KASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLE-----ELKQKIKDINDQ 614 +SS ++ L ++P S ++ L ++E L+QK + + ++ Sbjct: 988 SSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEE 1047 Query: 615 MDESFRELDMECALLDGEQKSETTEL---------------MKEKEILDHLNRKIAELEK 659 EL + A E + + L + IL HL A E+ Sbjct: 1048 QRRRLAELKQKAA---AEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLP---AGRER 1101 Query: 660 NIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP----------ESMREQLQQQLK 709 GE + + L++ + +E DN E M + L++ Sbjct: 1102 GEEGEHAYDTLSLESS-DSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHA 1160 Query: 710 RDADLLDVESKHFEDLEFQQLEHESRLDEEKE-NLTQQLLREVAEYQRNIVSRKEKISAL 768 L++ + E L Q LE E R E+ E L + R ++ + R+++ S Sbjct: 1161 EKNRLMESREREME-LRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQA 1219 Query: 769 KKQANHI 775 + ++ Sbjct: 1220 RPLTRYL 1226 >gi|38424073 pleckstrin homology-like domain, family B, member 1 isoform a [Homo sapiens] Length = 1377 Score = 620 bits (1600), Expect = e-177 Identities = 388/893 (43%), Positives = 524/893 (58%), Gaps = 133/893 (14%) Query: 407 PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 465 P RERK+SI+ IS DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D Sbjct: 570 PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629 Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525 G ++ I + L L+ P LA Sbjct: 630 ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663 Query: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585 S T R + E SD SST S++ + E + Sbjct: 664 SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711 Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645 E+ A+EE R +L ++E+LK ++K++ Q+ ES RE +ME ALL G Sbjct: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQG-------------- 757 Query: 646 ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQ 705 E+ E+ L E++ +++LQE +T + Q Sbjct: 758 ------------------EREAERALLQKEQKAVDQLQEKLVALETGI-----------Q 788 Query: 706 QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765 ++ ++A+ L+ E+K FEDLEFQQLE ESR++EE+E Q LLR AE R+I RKE++ Sbjct: 789 KERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERL 848 Query: 766 SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPN 825 + L QA I QA +E + ++KN + +LQ+EKE L LE++Y SL+GG+ FP + Sbjct: 849 AILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTS 908 Query: 826 TLKE-GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEE 884 TLKE + + ++ ++ PA A ++ P AS+ + +RS + Sbjct: 909 TLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASR--QLQVYRSKMD 966 Query: 885 RKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLA 944 + S LP +SS S S AT+GRS +PK+ L N GS LP +LA Sbjct: 967 GEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLT--QNGTGS-LPRNLA 1023 Query: 945 AMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFH-----------Y 991 A +D E++R L + Q + E R+ +E + A+E+ ++ H + Sbjct: 1024 ATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGF 1083 Query: 992 PD---HSYK-------------DQAFDTLSLDSSDSMETSIS-----ACSPDNISSASTS 1030 P HS + A+DTLSL+SSDSMETSIS ACSPDN+SSAS Sbjct: 1084 PPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGL 1143 Query: 1031 NIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1090 ++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RRRE +E+RLQ E+++RQ+ Sbjct: 1144 DMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQ 1203 Query: 1091 LIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFL 1150 L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +DTC HV ++ K CRG+L Sbjct: 1204 LVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYL 1263 Query: 1151 IKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANK--- 1207 +KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQAIEEVYYDHL++A K Sbjct: 1264 VKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRF 1323 Query: 1208 --------SPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFL 1252 SPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIVTGAEGYT F+ Sbjct: 1324 FRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFM 1376 Score = 34.3 bits (77), Expect = 0.77 Identities = 91/427 (21%), Positives = 157/427 (36%), Gaps = 59/427 (13%) Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLERQR 449 E+ +E R+ +G Q LR + + SI+ R + + Q + + QE ERL R + Sbjct: 816 ESRVEEERELAG--QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDK 873 Query: 450 LETILSLCAEYTKPD------SRLSTGTTVEDVQKINKELEKLQLS--DEESVFEEALMS 501 ++ L E K L+ G KE+EKL L D E ++E + Sbjct: 874 NASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAG 933 Query: 502 PDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDL--TRTPPPPSSTFP 559 T S P A ++S RS + E S L TR+ P PSS+ Sbjct: 934 LGTGPAAASPHSSPPPLPA------KASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGS 987 Query: 560 KASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLE-----ELKQKIKDINDQ 614 +SS ++ L ++P S ++ L ++E L+QK + + ++ Sbjct: 988 SSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEE 1047 Query: 615 MDESFRELDMECALLDGEQKSETTEL---------------MKEKEILDHLNRKIAELEK 659 EL + A E + + L + IL HL A E+ Sbjct: 1048 QRRRLAELKQKAA---AEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLP---AGRER 1101 Query: 660 NIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP----------ESMREQLQQQLK 709 GE + + L++ + +E DN E M + L++ Sbjct: 1102 GEEGEHAYDTLSLESS-DSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHA 1160 Query: 710 RDADLLDVESKHFEDLEFQQLEHESRLDEEKE-NLTQQLLREVAEYQRNIVSRKEKISAL 768 L++ + E L Q LE E R E+ E L + R ++ + R+++ S Sbjct: 1161 EKNRLMESREREME-LRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQA 1219 Query: 769 KKQANHI 775 + ++ Sbjct: 1220 RPLTRYL 1226 >gi|157266264 pleckstrin homology-like domain, family B, member 3 [Homo sapiens] Length = 640 Score = 201 bits (510), Expect = 5e-51 Identities = 111/212 (52%), Positives = 130/212 (61%), Gaps = 31/212 (14%) Query: 1035 IEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEK 1094 I MERLL+QA AE+ RLL++R E +R E Sbjct: 455 IAHMERLLQQAMAERERLLKAR----EGTRRGTEGSSG---------------------- 488 Query: 1095 EVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMG 1154 A P T P DLR H+E GHN + C HV ++ CRG L+KMG Sbjct: 489 -----PAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMG 543 Query: 1155 GKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLT 1214 G+IKTW+KRWF FDR R +YYADK ETKLKGVIYFQAIEEVYYDHL+ A KSPNP LT Sbjct: 544 GRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLT 603 Query: 1215 FSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAE 1246 F VKT++R++YMVAPSPEAMRIWMDVIVT A+ Sbjct: 604 FCVKTYERLFYMVAPSPEAMRIWMDVIVTAAD 635 Score = 114 bits (284), Expect = 8e-25 Identities = 110/418 (26%), Positives = 189/418 (45%), Gaps = 66/418 (15%) Query: 550 TPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIK 609 TPP + P AS+ S + G + + Q+L A+ TR+ ++ +Q++K Sbjct: 75 TPPIAMAATPPASTSSR------EGVRGAARRLQGQQLEAL--TRVALM------EQRVK 120 Query: 610 DINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEK 669 ++ Q E E+++E ALL GE E +E+E L L + A E+ ++ +E+ Sbjct: 121 ELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQ 180 Query: 670 VKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQ 729 +L ER++LE L++ + + QLD+ PE RE+L Q ++ + LDV + +EDLEFQQ Sbjct: 181 RRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQ 240 Query: 730 LEHESRLDEEKEN---------LTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780 LE ESR +EE + Q+L +A+++R + + +I L++Q + +Q Sbjct: 241 LERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGAL--QHRIRVLEEQLKSLGEQMA 298 Query: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840 E ++K + L +E+ L L + L G G + +EP Sbjct: 299 AESRGLSRKKEEALQALSQERSRLLEL----NCLQGTPG---------------GDFSEP 339 Query: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900 T L + + D + + A A A+ P S F Q GL + +LP Sbjct: 340 NPALTKLLFTQK--TDRQLLVLQDAVAHSAATPTSSCLFS--VHSSLQGSIGLQRTGSLP 395 Query: 901 RKK--------TTSSISPHFSSATMGRSITP----KAHLPL------GQSNSCGSVLP 940 RK+ + +S H + + ++ P PL G+ NSCG++ P Sbjct: 396 RKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHP 453 >gi|21735548 centrosomal protein 2 [Homo sapiens] Length = 2442 Score = 67.0 bits (162), Expect = 1e-10 Identities = 118/594 (19%), Positives = 248/594 (41%), Gaps = 93/594 (15%) Query: 573 KTPEGISEEQRSQELA-----------AMEETRIVILNNLEELKQKIKDINDQMDESFRE 621 K E SE +R+Q L A++E ++ L E +++++ + Q+ E ++ Sbjct: 1391 KNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ 1450 Query: 622 LDMECALLD-------------GEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKE 668 +M+ A L+ Q+ + EL K + +L+HL + E E+ + ++ + Sbjct: 1451 REMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI 1510 Query: 669 KVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADL----LDVESKHFED 724 + +L+ +RE + E + + D ES R Q+Q K+ L L++E H + Sbjct: 1511 R-ELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK- 1568 Query: 725 LEFQQL---EHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQR 781 +E QQ E E + + ++ LT L ++ E + + ++ +I L+ + + ++ Q Sbjct: 1569 MECQQKLIKELEGQRETQRVALTHLTL-DLEERSQELQAQSSQIHDLESHSTVLARELQ- 1626 Query: 782 EQDHFVKEKNNLIMMLQREKENLC-NLEKKYSSL------------SGGKGFPVNPNTLK 828 E+D VK + I LQR+KE+L +LE++ L + + L+ Sbjct: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686 Query: 829 EGYISVNEINEPCGNSTNL----SPSTQFPADADAVATEPATAVLASQPQ----SKEHFR 880 + +S+ E L + + P+ A + E +L + + +EH Sbjct: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746 Query: 881 SLEERKKQHKEGLYLSDTLPRKKTTSSI---SPHFSSATMGRSITPKAHLPLGQSNSCGS 937 L+E K Q ++ L L RK +S+ + + + + S S Sbjct: 1747 ELQELKDQLEQQL---QGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQS 1803 Query: 938 VLPPSLAAMAKDSESRRMLRGYNHQQMSEGH----RQKSEFYNRTASESNVYLNSFHYPD 993 L + A+A+ + L+ QQ ++G ++K++ ++++ L H Sbjct: 1804 QLDEAQRALAQRDQELEALQ--QEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGEL 1861 Query: 994 HSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLL 1053 +K+QA L+ ++E R++ +E +L AE Sbjct: 1862 QDHKEQA---RRLEEELAVEG------------------RRVQALEEVLGDLRAES---- 1896 Query: 1054 ESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQAR 1107 +E+ + A ++ E+ + E+ + LQ+ Q Q ++++ + E RA+++ Sbjct: 1897 REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQ 1950 Score = 60.5 bits (145), Expect = 1e-08 Identities = 131/596 (21%), Positives = 246/596 (41%), Gaps = 103/596 (17%) Query: 581 EQRSQELAA-------MEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ 633 E+RSQEL A +E V+ L+E Q++K +Q++E R+ E D E+ Sbjct: 1598 EERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQ--KEHLTQDLER 1655 Query: 634 KSETTELMKEK-EIL-DHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKT 691 + + L KE+ ++L D R+ LE+++ E++KL ER +EL ++++ Sbjct: 1656 RDQELMLQKERIQVLEDQRTRQTKILEEDL------EQIKLSLR----ERGRELTTQRQL 1705 Query: 692 QLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL--- 748 + E Q+ + L + K +++E QQ EH L E K+ L QQL Sbjct: 1706 MQERAEEGKGPSKAQRGSLEHMKLILRDKE-KEVECQQ-EHIHELQELKDQLEQQLQGLH 1763 Query: 749 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 808 R+V E + R+++I L++Q +Q + ++ + + L + + L L+ Sbjct: 1764 RKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQ 1823 Query: 809 KKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAV 868 ++ G + +KE ADA A E A Sbjct: 1824 QEQQQAQGQE------ERVKE------------------------KADALQGALEQAHMT 1853 Query: 869 LASQ----PQSKEHFRSLEE------RKKQHKE---GLYLSDTLPRKKTTSSISPHFSSA 915 L + KE R LEE R+ Q E G +++ ++K ++ + Sbjct: 1854 LKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQ 1913 Query: 916 TMGRSITPKAHLPLG-QSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEF 974 + +A Q+ + L A+ +S+S R HQ+ E R ++E Sbjct: 1914 AQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSR------HQE--EAARARAEA 1965 Query: 975 YNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDS-METSISACSPDNISSASTSNIA 1033 +++ L + +QA + SL++S + ++ S+ AC + I Sbjct: 1966 LQEALGKAHAALQG---KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQ 2022 Query: 1034 ---------RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEE 1084 R +E + L+QA A++ L R + +++ LE+ +R + E +QE+ Sbjct: 2023 EGEIQDQDLRYQEDVQQLQQALAQRDEEL----RHQQEREQLLEKSLAQR-VQENMIQEK 2077 Query: 1085 TSQRQKLIEKEVK-----IRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDT 1135 + Q+ E+E++ +RE Q A+ L +R + R+++E H+ T Sbjct: 2078 QNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELR--ETQQRNNLEALPHSHKT 2131 Score = 53.1 bits (126), Expect = 2e-06 Identities = 126/582 (21%), Positives = 237/582 (40%), Gaps = 97/582 (16%) Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQM---DESFRELDMECALLDGEQKSETT 638 Q +LAA++E +L + +L+++++D+ Q+ D+S R ++ E E+ ET Sbjct: 986 QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQ----EKLRETQ 1041 Query: 639 ELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPE 698 E + ++K + EK + L + ++L LQE S ++ +L + Sbjct: 1042 EYNR--------------IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQ 1087 Query: 699 SMREQL--QQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKE--NLTQQLLR----- 749 M+E Q++L +LL E K + E L E++L EE E ++T+Q LR Sbjct: 1088 DMQEAQGEQKELSAQMELLRQEVK---EKEADFLAQEAQLLEELEASHITEQQLRASLWA 1144 Query: 750 ---EVAEYQ---RNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKEN 803 + A+ Q R+ S+ E ++A ++ N QAQ +L LQ+ + Sbjct: 1145 QEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLA---------SLYSALQQALGS 1195 Query: 804 LCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPS----TQFPADADA 859 +C + S GG P SV + + +L T A+A A Sbjct: 1196 VCESRPELS--GGGDSAP-----------SVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242 Query: 860 VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGR 919 A L Q+++ R ++ ++ L+DT K H + R Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEER-----LTDTEAEKSQV-----HTELQDLQR 1292 Query: 920 SITPKAHLPL---GQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN 976 ++ G+ NS S L MA S R+ R + ++G R+ + Sbjct: 1293 QLSQNQEEKSKWEGKQNSLESELMELHETMA--SLQSRLRRAELQRMEAQGERELLQ--- 1347 Query: 977 RTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIE 1036 A++ N+ H + +A + + + + T+ SA N S A+ Sbjct: 1348 --AAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQAL 1405 Query: 1037 EMERLLKQAHAEK--------TRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQR 1088 + + LK A + T+ L RE E+E + ++E +++RE ++K E S Sbjct: 1406 QEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQRE-MQKAALELLSLD 1464 Query: 1089 QKLIEKEVKIRERQ---RAQARPLTRYLPVRKEDFDLRSHVE 1127 K +EV +++ Q + R + +LP+ ++ + + V+ Sbjct: 1465 LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQ 1506 Score = 50.8 bits (120), Expect = 8e-06 Identities = 52/226 (23%), Positives = 109/226 (48%), Gaps = 24/226 (10%) Query: 585 QELAAMEETRIVILNNLEELKQKIKDINDQMD--ESFRELDMECALLDGEQKSETTELMK 642 QE A+ + + L+ +++ +D+ +Q+ S +EL +E +L + +Q++ E+ K Sbjct: 729 QEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKEL-LESSLFEAQQQNSVIEVTK 787 Query: 643 EKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMRE 702 + L+ + + + ++ I GE K++LD ER + E+ ++ + Q Q + ++ E Sbjct: 788 GQ--LEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE 845 Query: 703 QLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRK 762 Q + +++ + L E E ++ H+ L + E+L RE E + + ++ Sbjct: 846 QQKAAHEKEVNQLR------EKWEKERSWHQQELAKALESLE----REKMELEMRLKEQQ 895 Query: 763 EKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 808 ++ A+ QAQRE++ E M L+ EKE + LE Sbjct: 896 TEMEAI---------QAQREEERTQAESALCQMQLETEKERVSLLE 932 Score = 49.3 bits (116), Expect = 2e-05 Identities = 108/505 (21%), Positives = 210/505 (41%), Gaps = 52/505 (10%) Query: 427 DYHRRQREERLREQEMERLERQRL-ETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEK 485 D + Q+EE+ E + ER+RL E ++ L A+ ++ S L T + + EL + Sbjct: 501 DSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLR 560 Query: 486 LQLSDEESVFEEALMSPDTRYRCHRKDSLPDADL-ASCGSLSQSSASFFTPRSTRNDELL 544 + ++ + A S ADL A+ LS + + + N +LL Sbjct: 561 QEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLL 620 Query: 545 SDLTRTPPPPSSTFPKASSESSYLSI----LPKTPEGISEEQRSQE--LAAMEETRIVIL 598 L S A + L + K E + E+ E L EE + Sbjct: 621 -QLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQ 679 Query: 599 NNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELE 658 +L +++++ ++I ++ ES + E A EQ + E +++E+ L R + E E Sbjct: 680 ADLRDIQEEKEEIQKKLSESRHQ--QEAATTQLEQLHQ--EAKRQEEV---LARAVQEKE 732 Query: 659 KNIVGEKTKEKVKLDA-EREK---LERLQELYSEQK---------TQLDNCPESMREQLQ 705 +V EK +V+L A ER++ E+LQ L S ++ Q ++ E + QL+ Sbjct: 733 A-LVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLE 791 Query: 706 QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765 Q++ +V L+ + S+ ++E++ +QL + E + + +K Sbjct: 792 VQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQK--- 848 Query: 766 SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENL-CNLEKKYSSLSGGKGFPVNP 824 +A +K+ N + ++ ++E+ +E + L+REK L L+++ + + + Sbjct: 849 AAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEE 908 Query: 825 NTLKEGYISVNEINEPCGNSTNLSPSTQFPAD-ADA---------------VATEPATAV 868 T E + ++ + L Q + ADA + + T + Sbjct: 909 RTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI 968 Query: 869 LASQPQSKEHFRSLEERKKQHKEGL 893 L Q Q +E R L+E +QH++ L Sbjct: 969 L--QTQLQEAQRELKEAARQHRDDL 991 Score = 48.5 bits (114), Expect = 4e-05 Identities = 142/736 (19%), Positives = 277/736 (37%), Gaps = 97/736 (13%) Query: 417 SSISGRDDLMDYHRRQREERLRE-QEMERLERQRLETILSLCAEYTKPDSRLSTGTTVED 475 S + +DD ++ +E+LRE QE R++++ SL + + RL + Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADS 1076 Query: 476 VQKINKELEKLQLSDEESVFEEALMSPDTRY-RCHRKDSLPDADLASCGSLSQSSASFFT 534 +++ +EL L+ +E+ E+ +S R K+ D L + AS T Sbjct: 1077 IRQ--QELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHIT 1134 Query: 535 PRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETR 594 + R + L + + S S L L + ++ Q +LA++ Sbjct: 1135 EQQLR-----ASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSAL 1189 Query: 595 IVILNNLEELKQKIKDINDQMDESF---------RELDMECALLDGEQKSETT------- 638 L ++ E + ++ D + R L LL Sbjct: 1190 QQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249 Query: 639 -ELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP 697 +L K ++ D L ++ +LE+ + + EK ++ E + L+R E+K++ + Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEA-EKSQVHTELQDLQRQLSQNQEEKSKWEGKQ 1308 Query: 698 ESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESR---LDEEKENLTQQLLREVAEY 754 S+ +L + + A L E Q++E + L KENLT Q V Sbjct: 1309 NSLESELMELHETMASL----QSRLRRAELQRMEAQGERELLQAAKENLTAQ----VEHL 1360 Query: 755 QRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 814 Q +V + + SA I+++ R +K KN + + E+E L+++ L Sbjct: 1361 QAAVVEARAQASAAG-----ILEEDLRTARSALKLKNEEV---ESERERAQALQEQ-GEL 1411 Query: 815 SGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQ 874 +G L+E NL+ TQ A+ E L Q Q Sbjct: 1412 KVAQG-----KALQE----------------NLALLTQTLAER-----EEEVETLRGQIQ 1445 Query: 875 SKEHFRSLEERKKQHKEGLYLS--DTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQS 932 LE++++ K L L D R + RS+ + + + Sbjct: 1446 E------LEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQER 1499 Query: 933 NSCGSVLPPSLAAMAKDSESRR------MLRGYNHQQMSEGHRQKSEFYNRTASESNVYL 986 +V + + KD E++R +L QM E Q+ + + + Sbjct: 1500 EQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIES--QRGQVQDLKKQLVTLEC 1557 Query: 987 NSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAH 1046 + ++ +K + L + ET A + + S + + + ++H Sbjct: 1558 LALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESH 1617 Query: 1047 AEK-TRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQ 1105 + R L+ R++E+++++ +EE +R++E L + L E Q L ++ +++ E QR Sbjct: 1618 STVLARELQERDQEVKSQREQIEELQRQKEHLTQDL-ERRDQELMLQKERIQVLEDQR-- 1674 Query: 1106 ARPLTRYLPVRKEDFD 1121 TR + +ED + Sbjct: 1675 ----TRQTKILEEDLE 1686 Score = 47.8 bits (112), Expect = 7e-05 Identities = 52/242 (21%), Positives = 110/242 (45%), Gaps = 16/242 (6%) Query: 580 EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTE 639 + +R +E A+E R+ LEE+ ++ + + +++ L +CA E + ET Sbjct: 1867 QARRLEEELAVEGRRV---QALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRA 1923 Query: 640 L----MKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDN 695 L ++ + +L ++++ L + +E +A R + E LQE + L Sbjct: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQE----EAARARAEALQEALGKAHAALQG 1979 Query: 696 CPESMREQLQQQLKRDADLLDVE-SKHFEDLEFQQLEHESRLDE-EKENLTQQLLREVAE 753 + + EQ + +A ++ S +QLE R+ E E ++ + +V + Sbjct: 1980 KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ 2039 Query: 754 YQRNIVSRKEKISALKKQANHIVQQ-AQREQDHFVKEKNNLIMMLQREKENLCNLEKKYS 812 Q+ + R E++ +++ + + AQR Q++ ++EK NL +RE+E + L + Sbjct: 2040 LQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQ--EREEEEIRGLHQSVR 2097 Query: 813 SL 814 L Sbjct: 2098 EL 2099 Score = 47.0 bits (110), Expect = 1e-04 Identities = 138/765 (18%), Positives = 295/765 (38%), Gaps = 93/765 (12%) Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 451 EA L+ +A Q LR+ + I + + R Q+E + E E +R E Sbjct: 665 EAQLQKAEEAGAELQADLRDIQEEKEEIQKK---LSESRHQQEAATTQLEQLHQEAKRQE 721 Query: 452 TILSLCAEYTKPDSRLSTGTTV--EDVQKINKEL-EKLQ-LSDEESVFEEALMSPDTRYR 507 +L+ + + R V + V++ ++L E+LQ LS + + E +L + Sbjct: 722 EVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSL------FE 775 Query: 508 CHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSY 567 +++S+ + + G L + + E+ S + + + Sbjct: 776 AQQQNSVIEV---TKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQ 832 Query: 568 LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQ----MDESFRELD 623 L+ + + E+Q+ AA E+ +N L E +K + + Q ES Sbjct: 833 LAQAEQEGKTALEQQK----AAHEKE----VNQLREKWEKERSWHQQELAKALESLEREK 884 Query: 624 MECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQ 683 ME + EQ++E + ++E E+ E +++L+ E+E++ L+ Sbjct: 885 MELEMRLKEQQTEMEAIQAQRE------------EERTQAESALCQMQLETEKERVSLLE 932 Query: 684 ELYSEQKTQLDNCP--ESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKE 741 L QK D E +R+ ++ Q ++ + + ++ + + E + ++ Sbjct: 933 TLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLA 992 Query: 742 NLTQQ---LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQ 798 L ++ LL++ + Q+ + K ++ A + + +V+Q +E+ +E N + L+ Sbjct: 993 ALQEESSSLLQDKMDLQKQVEDLKSQLVA-QDDSQRLVEQEVQEKLRETQEYNRIQKELE 1051 Query: 799 REKEN--LCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPAD 856 REK + L +EK+ L + + L ++ E G LS + Sbjct: 1052 REKASLTLSLMEKEQRLLVLQEADSIRQQELS---ALRQDMQEAQGEQKELSAQMELLRQ 1108 Query: 857 ADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDT------LPRKKTTSSISP 910 E LA + Q E + ++Q + L+ + L + T S + Sbjct: 1109 E---VKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEA 1165 Query: 911 HFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQ 970 + G +A L S S L +L ++ ESR L G S + Sbjct: 1166 LAAEQQPGNQAQAQAQLA-----SLYSALQQALGSVC---ESRPELSGGGDSAPSVWGLE 1217 Query: 971 KSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTS 1030 + R+ + L + S++++ +++ D + T Sbjct: 1218 PDQNGARSLFKRGPLLTAL------------------SAEAVASALHKLHQDLWKTQQTR 1259 Query: 1031 NIAR--IEEMERLLKQAHAEKTRL---LESREREMEAKKRALEEEKRRREILEKRLQEET 1085 ++ R ++++E L AEK+++ L+ +R++ + + + ++ LE L E Sbjct: 1260 DVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELM-EL 1318 Query: 1086 SQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR-SHVETA 1129 + ++ ++ E QR +A+ L KE+ + H++ A Sbjct: 1319 HETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAA 1363 Score = 41.6 bits (96), Expect = 0.005 Identities = 123/711 (17%), Positives = 278/711 (39%), Gaps = 92/711 (12%) Query: 427 DYHRRQREERLREQEMERLERQRLE-TILSLCAEYTKPDSRLSTGTTVEDVQKINKELEK 485 ++H+ + +++L ++ + E QR+ T L+L E + + + + + D++ + L + Sbjct: 1565 NHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQS-SQIHDLESHSTVLAR 1623 Query: 486 -LQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELL 544 LQ D+E + + R + H L D L + + TR ++L Sbjct: 1624 ELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELM--LQKERIQVLEDQRTRQTKIL 1681 Query: 545 S-DLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEE 603 DL + + +++ + + +G S+ QR ++E ++++ + +E Sbjct: 1682 EEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRG----SLEHMKLILRDKEKE 1737 Query: 604 LK------QKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAEL 657 ++ +++++ DQ+++ + L + ET+ L+ ++E ++I L Sbjct: 1738 VECQQEHIHELQELKDQLEQQLQGLHRKVG--------ETSLLLSQRE------QEIVVL 1783 Query: 658 EKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV 717 ++ + + + ++K + + +L+ Q +++ +L+ + ++Q Q Q +R + D Sbjct: 1784 QQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE-QQQAQGQEERVKEKADA 1842 Query: 718 ESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH--- 774 E E L + KE ++L E+A R + + +E + L+ ++ Sbjct: 1843 LQGALEQAHMTLKERHGELQDHKEQ-ARRLEEELAVEGRRVQALEEVLGDLRAESREQEK 1901 Query: 775 ----IVQQ-AQREQDHFVKEKNNLIMMLQRE---KENLCNLE----KKYSSLSGGKGFPV 822 + QQ A++ Q+H V+ + LQ + KE LE + SS + Sbjct: 1902 ALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARA 1961 Query: 823 NPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSK--EHFR 880 L+E + + G +L + +A ++ A Q S+ E Sbjct: 1962 RAEALQEALGKAHAALQ--GKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL 2019 Query: 881 SLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLP 940 ++E + Q ++ Y D ++ + + K+ Q N Sbjct: 2020 RIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQE--K 2077 Query: 941 PSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQA 1000 +L ++ E R + + Q++ +++ R + N + HS+K Sbjct: 2078 QNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRN----NLEALPHSHKTSP 2133 Query: 1001 FDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREM 1060 + SL DS+E + E+ERL + R +E RE+ Sbjct: 2134 MEEQSL-KLDSLEPRLQ------------------RELERLQAALRQTEAREIEWREKAQ 2174 Query: 1061 E-----AKKRA-----------LEEEKRRREILEKRLQEETSQRQKLIEKE 1095 + A+ +A L+ R+ ++RLQ+E ++ +EKE Sbjct: 2175 DLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE 2225 >gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] Length = 2017 Score = 66.6 bits (161), Expect = 1e-10 Identities = 125/596 (20%), Positives = 230/596 (38%), Gaps = 75/596 (12%) Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMD----------------ESFR-ELD 623 E+ ++L +E R V+ L E+++ + Q D E+ R EL+ Sbjct: 662 ERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELE 721 Query: 624 MECALLDGEQKSETTELMKEKEILDHL-------NRKIAELEKN---IVGEKTKEKVKLD 673 + L E+ S L K + + L NR +A+LE+ + G + + + + Sbjct: 722 LSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT 781 Query: 674 AEREKLERLQELYSEQKTQLDNCPESMR--EQLQQQLKRDADLLDVESKHFEDLEFQQLE 731 RE+ ERL+EL EQ+ S+R EQ Q+ L++ L E ++ Q Sbjct: 782 VAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSR 841 Query: 732 HESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ--QAQREQDHFVKE 789 S ++E E ++ R+V +R + +EK + K+ A VQ A+RE +E Sbjct: 842 QLSGREQELEQARREAQRQVEALER---AAREKEALAKEHAGLAVQLVAAEREGRTLSEE 898 Query: 790 KNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSP 849 L + + + +L ++++ + L + EG + G L Sbjct: 899 ATRLRLEKEALEGSLFEVQRQLAQLEARR-----EQLEAEGQALLLAKETLTGELAGLRQ 953 Query: 850 STQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSIS 909 Q A + + + +E SL E++ H+E L L R+K + Sbjct: 954 --QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL---QRLQREKEAAWRE 1008 Query: 910 PHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHR 969 A + + + L + + L +AA+ ++ + +L Sbjct: 1009 LEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLL----------AES 1058 Query: 970 QKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNIS-SAS 1028 +K + + SE HS T+SL+ + S D + +A Sbjct: 1059 EKQQALSLKESEKTALSEKLMGTRHSLA-----TISLEMERQKRDAQSRQEQDRSTVNAL 1113 Query: 1029 TSNIARIEEMERLLKQAHAEKTRLLESREREM-EAKKRALEEEKRRREILEKRLQEETSQ 1087 TS + + AHA++ R L+ + R++ + + L E + R L Sbjct: 1114 TSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGL 1173 Query: 1088 RQKLIEKEVKIRER------QRAQARPLTRYL--------PVRKEDFDLRSHVETA 1129 R++L+E + K+RE QR +A L R L +R+ + +LRS V+ A Sbjct: 1174 RRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKA 1229 Score = 55.5 bits (132), Expect = 3e-07 Identities = 92/452 (20%), Positives = 181/452 (40%), Gaps = 44/452 (9%) Query: 369 LAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDY 428 LAG ++ AT+ S E + L QA Q +LRE++++ ++ + Sbjct: 948 LAGLRQQIIATQEKASLDK----ELMAQKLVQAEREAQASLREQRAA------HEEDLQR 997 Query: 429 HRRQREERLREQEMER------LERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKE 482 +R++E RE E ER L+R++ E + L AE + ++ D + E Sbjct: 998 LQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE 1057 Query: 483 LEKLQL----SDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRST 538 EK Q E++ E LM TR+ + S + S ++ Sbjct: 1058 SEKQQALSLKESEKTALSEKLMG--TRHSLATISLEMERQKRDAQSRQEQDRSTVNALTS 1115 Query: 539 RNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVIL 598 +L + + + ++ L + +EE R+Q L +E+ R + Sbjct: 1116 ELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQ-LRLLEDARDGLR 1174 Query: 599 NNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELE 658 L E ++K+++ + RE+ + A GE + E KE+E L N ++ Sbjct: 1175 RELLEAQRKLRE-----SQEGREVQRQEA---GELRRSLGEGAKEREALRRSNEELRSAV 1226 Query: 659 KNIVGEKTKEKVKLDAEREKLERLQELYS-------EQKTQLDNCPESMREQLQ--QQLK 709 K E+ K+ + + +KL L+E + E +T L S E + Q+L+ Sbjct: 1227 KKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELR 1286 Query: 710 RDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALK 769 R +LD E+ E +L+ L E E ++ RE ++ ++ + + ++ Sbjct: 1287 RQMKMLDSENTRL-GRELAELQGRLALGERAE---KESRRETLGLRQRLLKGEASLEVMR 1342 Query: 770 KQANHIVQQAQREQDHFVKEKNNLIMMLQREK 801 ++ ++ Q ++ F + L+ L+ + Sbjct: 1343 QELQVAQRKLQEQEGEFRTRERRLLGSLEEAR 1374 Score = 48.1 bits (113), Expect = 5e-05 Identities = 44/153 (28%), Positives = 74/153 (48%), Gaps = 7/153 (4%) Query: 667 KEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDL- 725 K ++++ R + E Q+L + QL + ES R L++QL+R D D + ED Sbjct: 530 KRQLQVQDMRGRYEASQDLLGTLRKQLSDS-ESERRALEEQLQRLRDKTDGAMQAHEDAQ 588 Query: 726 -EFQQLEHESRL-DEEKENLTQQLLREVAEYQ-RNIVSRKEKISALKKQANHIVQQAQRE 782 E Q+L + L EK NL L +VA+ Q + +EK+ A +++ + + E Sbjct: 589 REVQRLRSANELLSREKSNLAHSL--QVAQQQAEELRQEREKLQAAQEELRRQRDRLEEE 646 Query: 783 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS 815 Q+ V++ + L+R L LE K S L+ Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLA 679 Score = 43.9 bits (102), Expect = 0.001 Identities = 155/774 (20%), Positives = 291/774 (37%), Gaps = 140/774 (18%) Query: 373 SDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQ 432 S+++ TR + + S+E + ++ Q + +S++++++ +L D R Q Sbjct: 1075 SEKLMGTRHSLATISLEMERQKRDA--------QSRQEQDRSTVNALTS--ELRDL-RAQ 1123 Query: 433 REERL--REQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSD 490 REE QE+ RL+ Q D + + + +++ +L L+ D Sbjct: 1124 REEAAAAHAQEVRRLQEQAR-------------DLGKQRDSCLREAEELRTQLRLLE--D 1168 Query: 491 EESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRT 550 L+ + R ++ + G L +S R L R+ Sbjct: 1169 ARDGLRRELLEAQRKLRESQEGR--EVQRQEAGELRRSLGEGAKEREA--------LRRS 1218 Query: 551 PPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKD 610 S KA SE L + + E + Q+LA +EE R + EL+ +++ Sbjct: 1219 NEELRSAVKKAESERISLKL--------ANEDKEQKLALLEEARTAVGKEAGELRTGLQE 1270 Query: 611 INDQMDESFRELDMECALLDGEQKSETTELMKEKEILD----HLNRKIAELEKNI-VGEK 665 + E+ REL EL ++ ++LD L R++AEL+ + +GE+ Sbjct: 1271 VERSRLEARRELQ---------------ELRRQMKMLDSENTRLGRELAELQGRLALGER 1315 Query: 666 TKEKVKLD--AEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFE 723 +++ + + R++L + + + +L ++EQ + R+ LL + Sbjct: 1316 AEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLG-SLEEAR 1374 Query: 724 DLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQ 783 E QQL+H L+ + E E AE + + + + L+ + + Q + + Sbjct: 1375 GTEKQQLDHARGLELKLE----AARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAE 1430 Query: 784 DHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGN 843 + L L+R L + + P +P S +N P + Sbjct: 1431 ----AQLGGLRSALRR------GLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSP--S 1478 Query: 844 STNLSPSTQFPADADAVATEPATAVL---ASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900 + SP +Q P+ AT PA+ L A + +E + L +++ E Sbjct: 1479 TLECSPGSQPPSPGP--ATSPASPDLDPEAVRGALREFLQELRSAQRERDE--------- 1527 Query: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960 + TS+++ + R +S S A+A+ E+RR + G Sbjct: 1528 LRTQTSALNRQLAEMEAER-------------DSATSRARQLQKAVAESEEARRSVDGRL 1574 Query: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020 +E Q+ E R+ E L+ +L+ S S S Sbjct: 1575 SGVQAELALQE-ESVRRSERERRATLD--------------QVATLERSLQATESELRAS 1619 Query: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR------- 1073 + IS +N ++E +R LK E ESR ++E ++R+LE E +R Sbjct: 1620 QEKISKMK-ANETKLEGDKRRLK----EVLDASESRTVKLELQRRSLEGELQRSRLGLSD 1674 Query: 1074 REILEKRLQEETSQRQKLI-EKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHV 1126 RE + LQ+ Q+ + + EVK Q R V + + LR V Sbjct: 1675 REAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKV 1728 Score = 31.6 bits (70), Expect = 5.0 Identities = 34/168 (20%), Positives = 75/168 (44%), Gaps = 32/168 (19%) Query: 568 LSILPKTPEGISEEQRSQELAAM--EETRIVILNNLEEL-KQKIKDINDQMDESFRELDM 624 L L + + E+R E +A+ E+ R+ + L+++ ++K++ D + L Sbjct: 1847 LGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV-----RLSA 1901 Query: 625 ECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQE 684 E LD EL + + + L ++ LE++ + ++++DA++++LE QE Sbjct: 1902 EKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQS----HSPAQLEVDAQQQQLELQQE 1957 Query: 685 LYSEQKTQ--------------------LDNCPESMREQLQQQLKRDA 712 + + Q L+ +++ QLQQ+L+R + Sbjct: 1958 VERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSS 2005 Score = 31.2 bits (69), Expect = 6.5 Identities = 20/49 (40%), Positives = 30/49 (61%), Gaps = 4/49 (8%) Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEE 1084 +E+ERL + A A+ R LE+RER + R LEE+ L+ +LQ+E Sbjct: 1956 QEVERL-RSAQAQTERTLEARERAHRQRVRGLEEQV---STLKGQLQQE 2000 >gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] Length = 2230 Score = 65.9 bits (159), Expect = 2e-10 Identities = 157/749 (20%), Positives = 300/749 (40%), Gaps = 110/749 (14%) Query: 395 LESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETIL 454 LE+L+Q + L+ K +I S + L+ +E L+EQ ERL Q LE I Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLT----SEKEALQEQLDERL--QELEKIK 334 Query: 455 SL-CAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDS 513 L AE TK ++L D + + ++LE+ ++ ++ +T+ + H Sbjct: 335 DLHMAEKTKLITQL------RDAKNLIEQLEQ----------DKGMVIAETKRQMHETLE 378 Query: 514 LPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPK 573 + + ++A S + +T+ +EL ++ KA S + + Sbjct: 379 MKEEEIAQLRSRIKQM-------TTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431 Query: 574 TPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ 633 + +EQ EE RI + L +KQ++ D+ + E + A L Q Sbjct: 432 KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEE------QIAKL---Q 482 Query: 634 KSETTEL-MKEKEILDHL---NRKIAELEKNIVGEKTKEKVKLDAEREKLE--RLQELYS 687 K EL KE+E+ L R+ E K + + E +K+ E+E+ E L+EL Sbjct: 483 KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELEL 542 Query: 688 EQKTQLDNCPESMREQLQQQLKRDADLLDVES---KHFEDLEFQQLEHESRLDEEKENLT 744 ++K L +R+ Q+ +L++ES K ++ + Q + L+ EK Sbjct: 543 QKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHN 602 Query: 745 QQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENL 804 +++ V +++ + S K + AL + +++Q + + ++EK ++EKE L Sbjct: 603 KEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK------CEQEKETL 656 Query: 805 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEP 864 K + +N TL++ + E+ +LS A E Sbjct: 657 L---KDKEIIFQAHIEEMNEKTLEKLDVKQTELE-------SLSSELSEVLKARHKLEEE 706 Query: 865 ATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPK 924 + + + K+ + + +K H + ++ S I H S T K Sbjct: 707 LSVLKDQTDKMKQELEAKMDEQKNHHQ----------QQVDSIIKEHEVSIQR----TEK 752 Query: 925 AHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASES-- 982 A Q N L + K+ + + + H + E ++SE + AS Sbjct: 753 A--LKDQIN--------QLELLLKERD-KHLKEHQAHVENLEADIKRSEGELQQASAKLD 801 Query: 983 --NVYLNSFHYPDHSYKDQAFD----TLSLDSSDSMETSISACSPDNISSASTSNIARIE 1036 Y ++ H +Y++Q L L++ + T A T A Sbjct: 802 VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKI 861 Query: 1037 EMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKE- 1095 +++ L++Q LE + EME K ++L + + LE +E+ +Q L+EKE Sbjct: 862 QVQDLMQQ--------LEKQNSEMEQKVKSLTQVYESK--LEDGNKEQEQTKQILVEKEN 911 Query: 1096 --VKIRERQRAQARPLTRYLPVRKEDFDL 1122 +++RE Q+ + LT+ L +++ + Sbjct: 912 MILQMREGQKKEIEILTQKLSAKEDSIHI 940 Score = 65.1 bits (157), Expect = 4e-10 Identities = 139/752 (18%), Positives = 299/752 (39%), Gaps = 99/752 (13%) Query: 409 LRERKSSISSISGRDDLMDYHRRQREERLREQE--MERLERQRLETI--LSLCAEYTKPD 464 ++ K+ I S+ + + +++ E+E + +L+++ E I ++L E K + Sbjct: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELK-E 1364 Query: 465 SRLSTGTTVEDVQKINKELEK-LQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCG 523 ++ + + + +N +L+ + LS++E+ D +C D + D Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEE-KCELLDQVQDLSF-KVD 1422 Query: 524 SLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQR 583 +LS+ S + D+ + + S F + + L I E + Sbjct: 1423 TLSKEKISALE----QVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI--------QLELK 1470 Query: 584 SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKE 643 S+E +E ++ L++ ++ + +M++ +++ + + L+ E KS+T +M Sbjct: 1471 SKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM-- 1528 Query: 644 KEILDHLNRKIAELE------KNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP 697 E+ DH+ +K E+E KN +K E +L +KL+ QEL E+ ++ Sbjct: 1529 -ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKEL---VQKLQHFQELGEEKDNRVKEAE 1584 Query: 698 ESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRN 757 E + Q A+ L+ + K E + E L ++ L + ++AE +R Sbjct: 1585 EKILTLENQVYSMKAE-LETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKR- 1642 Query: 758 IVSRKEKISALKKQANHIVQQAQREQDHFVK----EKNNLIMMLQREKENLCNLEKKYSS 813 ++KI+A+KKQ ++ Q + +++ + K + L LQ + + LE+K S Sbjct: 1643 --KAEQKIAAIKKQ---LLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKS 1697 Query: 814 LSGGKGFP-VNPNTLKE--GYISVNEI-NEPCGNST----------NLSPSTQFPADADA 859 + + + P + K Y E ++ C T NL+ + Sbjct: 1698 VESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ 1757 Query: 860 VATEPATAVLASQPQSKEHFRSLEERK-KQHKEGL---YLSDTL--PRKKTTSSISPHFS 913 E ++ + Q +E LE + KQH++ +L + L KK + ++ H Sbjct: 1758 EKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVE 1817 Query: 914 SATMGRSITPKAHL---------PLGQSNSCGSVLPPSL----AAMAKDSESRRM----- 955 +I K +L L + +L + + + + E R+ Sbjct: 1818 KEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEEL 1877 Query: 956 ---LRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSM 1012 Q +G + +E E + H + + + +D + Sbjct: 1878 TSKYEKLQALQQMDGRNKPTELLEENTEEKS--------KSHLVQPKLLSNMEAQHND-L 1928 Query: 1013 ETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLE---SREREMEAKKRALEE 1069 E ++ + I R+++ R+L++ H ++ +L+ +ERE + K+ + Sbjct: 1929 EFKLAGAERE--KQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDL 1986 Query: 1070 EKRRREILEKRLQE-ETSQRQKLIEKEVKIRE 1100 E + L++ ++E T QK E E+ I+E Sbjct: 1987 ELKHNSTLKQLMREFNTQLAQKEQELEMTIKE 2018 Score = 62.4 bits (150), Expect = 3e-09 Identities = 161/816 (19%), Positives = 322/816 (39%), Gaps = 120/816 (14%) Query: 395 LESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLE--RQRLET 452 L+ L+Q T LRE+ +D + + + E + E+ +E+L+ + LE+ Sbjct: 631 LQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIF--QAHIEEMNEKTLEKLDVKQTELES 688 Query: 453 ILSLCAEYTKPDSRLSTGTTV--EDVQKINKELEKLQLSDEESVFEEALMS--PDTRYRC 508 + S +E K +L +V + K+ +ELE ++ ++++ ++ + S + Sbjct: 689 LSSELSEVLKARHKLEEELSVLKDQTDKMKQELEA-KMDEQKNHHQQQVDSIIKEHEVSI 747 Query: 509 HRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYL 568 R + + L + + L +D+ R+ K SY Sbjct: 748 QRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQ 807 Query: 569 SILPKTPEGISEE--QRSQELAAMEETRIVILNNLEELKQKIKDI--------------- 611 S + + E+ Q Q+L +E RI++ + E++ + KD+ Sbjct: 808 SATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLM 867 Query: 612 ------NDQMDESFRELDM--ECALLDGEQKSETT-ELMKEKEIL------------DHL 650 N +M++ + L E L DG ++ E T +++ EKE + + L Sbjct: 868 QQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEIL 927 Query: 651 NRKIAELEKNIV------------GEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPE 698 +K++ E +I EK EKVK A +E E L++ +Q+ +L E Sbjct: 928 TQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKA-KEMQETLKKKLLDQEAKLKKELE 986 Query: 699 SMREQLQQQLKR-DADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRN 757 + +L Q+ K+ +A +L++ + + E+ E+ E+LT+ RE+ + + Sbjct: 987 NTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDV-IS 1045 Query: 758 IVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGG 817 I +K A + Q H +Q ++EQ+ V E I++ EKE + N E + G Sbjct: 1046 IWEKKLNQQAEELQEIHEIQLQEKEQE--VAELKQKILLFGCEKEEM-NKEITWLKEEG- 1101 Query: 818 KGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKE 877 V +T ++NE+ E Q A +++A + + + K Sbjct: 1102 ----VKQDT------TLNELQEQL---------KQKSAHVNSLAQD--------ETKLKA 1134 Query: 878 HFRSLE-ERKKQHKEGLYLSDTLPRKKTTSSISPH-FSSATMGRSITPKAHLPLGQSN-- 933 H LE + K KE +L + L K + S T T + L S+ Sbjct: 1135 HLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEK 1194 Query: 934 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPD 993 S S+ SL E L + + + +E N ++S++N L+ + Sbjct: 1195 SNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQ 1254 Query: 994 HSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLL 1053 H + I C+ + + + ++ E + L + + T L Sbjct: 1255 HR-----------TTKVKEALLIKTCTVSELE----AQLRQLTEEQNTLNISFQQATHQL 1299 Query: 1054 ESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYL 1113 E +E ++++ K +E +E L+K E +Q+Q EKE I + ++ + + Sbjct: 1300 EEKENQIKSMKADIESLVTEKEALQK---EGGNQQQAASEKESCITQLKKELSENINAVT 1356 Query: 1114 PVRKEDFDLRSHVETAGH-----NIDTCYHVSITEK 1144 +++E + + + + N+ +S++EK Sbjct: 1357 LMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392 Score = 56.6 bits (135), Expect = 1e-07 Identities = 81/431 (18%), Positives = 184/431 (42%), Gaps = 50/431 (11%) Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 451 +A+LE+ ++ +++ ++ + ++ R + + +R EQ++ +++Q L Sbjct: 1598 KAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLS 1657 Query: 452 TILSLCAEYTK-PDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHR 510 + +Y K +S LS T ++ + + +L ES E L+ P + Sbjct: 1658 QMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAA 1717 Query: 511 KDSLPDADLASCGSLS-QSSASFFTPRSTRNDELLSDLTRTPPPP-SSTFPKASSESSYL 568 +AD C + + S T ++LL + + SS F L Sbjct: 1718 YTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERL 1777 Query: 569 --------------SILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQ 614 S++ E + E+ + L + N + KQ ++++ D Sbjct: 1778 IKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDD 1837 Query: 615 MDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLD- 673 + ++ +E ++ C +L+ +KI EL+ +V +K +V+++ Sbjct: 1838 VQKTLQEKELTCQILE---------------------QKIKELDSCLVRQKEVHRVEMEE 1876 Query: 674 --AEREKLERLQELYSEQK-TQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL 730 ++ EKL+ LQ++ K T+L E+ E+ + L + L ++E++H DLEF+ Sbjct: 1877 LTSKYEKLQALQQMDGRNKPTEL--LEENTEEKSKSHLVQPKLLSNMEAQH-NDLEFKL- 1932 Query: 731 EHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQAN-HIVQQAQREQDHFVKE 789 + + EK+ L ++++R + + ++++ LKK+ + ++ ++EQ+ + Sbjct: 1933 ---AGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELK 1989 Query: 790 KNNLIMMLQRE 800 N+ + L RE Sbjct: 1990 HNSTLKQLMRE 2000 Score = 55.8 bits (133), Expect = 2e-07 Identities = 115/621 (18%), Positives = 247/621 (39%), Gaps = 78/621 (12%) Query: 574 TPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ 633 T + I E ++ L + + + L + Q +++ ++ D +E + + L+ + Sbjct: 1535 TQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQV 1594 Query: 634 KSETTELMKEKEILDHLN-------RKIAELEKNIVGE--------KTKEKVKLDA-ERE 677 S EL +K+ L+H+N ++ LE + E K K + K+ A +++ Sbjct: 1595 YSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQ 1654 Query: 678 KLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL------E 731 L +++E + K ++ + +LQ++ +R+ +L+ + K E + + L + Sbjct: 1655 LLSQMEEKEEQYKKGTESHLSELNTKLQER-EREVHILEEKLKSVESSQSETLIVPRSAK 1713 Query: 732 HESRLDEEKENLTQQLLREVAE-----YQRNIVSRKEKISALKKQ-----ANHIVQQAQR 781 + + E++E +Q +++ E QRN+ +++ + + ++ ++H + Q Sbjct: 1714 NVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY 1773 Query: 782 EQ-----DHFVKEKNNLIMMLQREKENLCNLEKKYSSL-------SGGKGFPVNPNTLKE 829 ++ +H +++ M+ +E L KKYS + GGK L+ Sbjct: 1774 QERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLEN 1833 Query: 830 GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSK-EHFRSLEERKKQ 888 + V + + + + D+ V + V + SK E ++L++ + Sbjct: 1834 VFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGR 1893 Query: 889 HKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAK 948 +K L + K + + P S + + L + L + + K Sbjct: 1894 NKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREK--QKLGKEIVRLQK 1951 Query: 949 DSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDS 1008 D RMLR + Q++ ++ + + L H + F+T Sbjct: 1952 DL---RMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008 Query: 1009 SDSMETSISACSPDNISSASTSNIARIE----EMERLLKQAHAEK-----------TRLL 1053 +E +I + I+ A +E E +LLK+ AEK +L Sbjct: 2009 EQELEMTIK----ETINKAQEVEAELLESHQEETNQLLKKI-AEKDDDLKRTAKRYEEIL 2063 Query: 1054 ESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYL 1113 ++RE EM AK R L+ + E L+K+ Q++ Q + V I E Q A+ T Sbjct: 2064 DAREEEMTAKVRDLQTQ---LEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLIS 2120 Query: 1114 PVRKEDFDLRSHVETAGHNID 1134 + ++ + R + HN++ Sbjct: 2121 DSKLKEQEFREQI----HNLE 2137 Score = 51.6 bits (122), Expect = 5e-06 Identities = 92/449 (20%), Positives = 184/449 (40%), Gaps = 51/449 (11%) Query: 391 DEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLR-EQEMERLERQR 449 + A E L +A T Q R+ + + + + + EER+ +QE+ R++++ Sbjct: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMD--EQIKTIEKTSEEERISLQQELSRVKQEV 466 Query: 450 LETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCH 509 ++ + E +L Q++ K+L+ + +E + + AL + Y Sbjct: 467 VDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQM-KVALEKSQSEYLKI 525 Query: 510 RKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPP-------SSTFPKAS 562 ++ LA Q A T ++ L DL + S+ K+ Sbjct: 526 SQEKEQQESLALEELELQKKAIL-----TESENKLRDLQQEAETYRTRILELESSLEKSL 580 Query: 563 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELK-----QKIKDINDQMDE 617 E+ S + + ++E+ M E L +L+ + +K++ + Q Sbjct: 581 QENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQT 640 Query: 618 SFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAERE 677 +L +C EQ+ ET L+K+KEI+ A +E+ + EKT EK LD ++ Sbjct: 641 EMEKLREKC-----EQEKET--LLKDKEIIFQ-----AHIEE--MNEKTLEK--LDVKQT 684 Query: 678 KLERLQELYSEQKTQLDNCPESMR------EQLQQQLKRDADLLDVESKHFEDLEFQQLE 731 +LE L SE E + ++++Q+L+ D + ++ H + ++ E Sbjct: 685 ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMD--EQKNHHQQQVDSIIKE 742 Query: 732 HESRLDEEKENLTQQ------LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDH 785 HE + ++ L Q LL+E ++ + + E + A K++ +QQA + D Sbjct: 743 HEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDV 802 Query: 786 FVKEKNNLIMMLQREKENLCNLEKKYSSL 814 F ++ + +E L L++K L Sbjct: 803 FQSYQSATHEQTKAYEEQLAQLQQKLLDL 831 Score = 47.0 bits (110), Expect = 1e-04 Identities = 115/532 (21%), Positives = 216/532 (40%), Gaps = 62/532 (11%) Query: 602 EELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMK-EKEILDHLNRKIAELEKN 660 + L+ K + +E +LD+ C + +++T EL+ + + +I+ + Sbjct: 1197 KSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHR 1256 Query: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720 K +K E +L++L EQ T + ++ + +++ + + D+ES Sbjct: 1257 TTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESL 1316 Query: 721 HFEDLEFQQLE-HESRLDEEKENLTQQLLREVAE-------YQRNIVSRKEKISALKKQA 772 E Q+ ++ + EKE+ QL +E++E + + +K +IS+L KQ Sbjct: 1317 VTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQL 1376 Query: 773 NHIVQQAQREQDHFVKEKNNLIMMLQRE-KENLCNLEKKYSSLSGGKGFPVNPNTLKEGY 831 + Q Q + EK I L+++ E C L + LS F V+ TL + Sbjct: 1377 TDLNVQLQNSIS--LSEKEAAISSLRKQYDEEKCELLDQVQDLS----FKVD--TLSKEK 1428 Query: 832 ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQ----SKEHFRS------ 881 IS E + N + ++ A + T+ V Q Q SKE + Sbjct: 1429 ISALEQVDDWSNKFS-----EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINL 1483 Query: 882 -LEERKKQHK-----EGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLG--QSN 933 EE +Q+K +G D +K S++ S T R + + H+ + Sbjct: 1484 LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQT-ARIMELEDHITQKTIEIE 1542 Query: 934 SCGSVLPPSLAAMAKDSESRRMLRGYNH-QQMSE--GHRQKSEFYNRTASESNVYLNSFH 990 S VL KD E + +++ H Q++ E +R K E+ VY Sbjct: 1543 SLNEVLKNY--NQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMK-- 1598 Query: 991 YPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM---------ERL 1041 + K + + ++L S S E + A D + S S + +A ++ ++L Sbjct: 1599 -AELETKKKELEHVNL-SVKSKEEELKALE-DRLESESAAKLAELKRKAEQKIAAIKKQL 1655 Query: 1042 LKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQE-ETSQRQKLI 1092 L Q ++ + + E + L+E +R ILE++L+ E+SQ + LI Sbjct: 1656 LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLI 1707 Score = 45.8 bits (107), Expect = 3e-04 Identities = 139/739 (18%), Positives = 275/739 (37%), Gaps = 89/739 (12%) Query: 428 YHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQ 487 + +E +R E L R L+ S A + P S ED+ + L K Q Sbjct: 85 FRSSSKESLVRTSSRESLNRLDLD---SSTASFDPPSDMDSEA---EDLVGNSDSLNKEQ 138 Query: 488 LSDEESVFEEALMSPDTRYR--CHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLS 545 L E +L S +Y L G LSQS + +EL Sbjct: 139 LIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQM 198 Query: 546 DLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELK 605 D + Y+S+L + + R+ + + +L L +L+ Sbjct: 199 DQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPM------NVDVLKPLPQLE 252 Query: 606 QKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN----- 660 + + + + E D E + DG L + + ++L ++ E ++ Sbjct: 253 PQAEVFTKEENP---ESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQC 309 Query: 661 --IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVE 718 + EK + +LD ++LE++++L+ +KT+L + L +QL++D ++ E Sbjct: 310 TLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAK-NLIEQLEQDKGMVIAE 368 Query: 719 SKH--FEDLEFQQLEHESRLDEEKENLTQ--QLLREVAEYQRNIVSRKEKISALKKQANH 774 +K E LE ++ E K+ TQ +L + + +R EK + ++ Sbjct: 369 TKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEE 428 Query: 775 IVQQAQREQDHFVK--------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNT 826 ++ + E D +K E+ +L L R K+ + ++ KK S Sbjct: 429 ARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS-------------- 474 Query: 827 LKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERK 886 +E + +++E + E + + +S+ + + + K Sbjct: 475 -EEQIAKLQKLHE----KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEK 529 Query: 887 KQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAM 946 +Q +E L L + +KK + S R + +A + S L SL Sbjct: 530 EQ-QESLALEELELQKKAILT-----ESENKLRDLQQEAETYRTRILELESSLEKSLQEN 583 Query: 947 AKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSL 1006 S+ L + + ++ +++ + + +E L S + + + L Sbjct: 584 KNQSKD---LAVHLEAEKNKHNKEITVMVEKHKTE----LESLKHQQDALWTEKLQVLKQ 636 Query: 1007 DSSDSMETSISACSPDNISSASTSNI---ARIEEM-ERLLKQAHAEKTRL--LESREREM 1060 ME C + + I A IEEM E+ L++ ++T L L S E+ Sbjct: 637 QYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEV 696 Query: 1061 EAKKRALEEE--------KRRREILEKRLQEETSQRQKLI-----EKEVKIRERQRAQAR 1107 + LEEE + ++ LE ++ E+ + Q+ + E EV I+ ++A Sbjct: 697 LKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKD 756 Query: 1108 PLTRY-LPVRKEDFDLRSH 1125 + + L +++ D L+ H Sbjct: 757 QINQLELLLKERDKHLKEH 775 Score = 45.8 bits (107), Expect = 3e-04 Identities = 46/194 (23%), Positives = 93/194 (47%), Gaps = 13/194 (6%) Query: 568 LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMEC- 626 L IL K + EE+ QE +E L + LKQ +++ N Q+ + +EL+M Sbjct: 1964 LEILKKEYDQEREEKIKQEQEDLE------LKHNSTLKQLMREFNTQLAQKEQELEMTIK 2017 Query: 627 ALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDA-EREKLERLQEL 685 ++ Q+ E L +E + L +KIAE + ++ + + LDA E E ++++L Sbjct: 2018 ETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDL 2077 Query: 686 YSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEK-ENLT 744 +TQL+ + +++L+Q+ D + + + + L +S+L E++ Sbjct: 2078 ----QTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQI 2133 Query: 745 QQLLREVAEYQRNI 758 L + +Y++N+ Sbjct: 2134 HNLEDRLKKYEKNV 2147 >gi|115511012 coiled-coil domain containing 136 [Homo sapiens] Length = 1154 Score = 65.9 bits (159), Expect = 2e-10 Identities = 172/818 (21%), Positives = 312/818 (38%), Gaps = 138/818 (16%) Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 451 +A+++SLRQA+ + + E +S I+S+ ++DL R Q E ++MER+ Sbjct: 147 QAEIQSLRQAA---EDSATEHESDIASL--QEDLC---RMQNEL----EDMERIRGDYEM 194 Query: 452 TILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQ-----LSDEESVFEEALMS----- 501 I SL AE S S + D + +EL++L+ L++E +E+ S Sbjct: 195 EIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQL 254 Query: 502 ---PDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTF 558 R + + L L+ + SQ+S F L L Sbjct: 255 ADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMK 314 Query: 559 PKASSESSYLSILPKTPEGISEEQR---------SQELAAMEETRIVILNNLEELKQKI- 608 K L L + EEQR E+ + + V N EELK ++ Sbjct: 315 NKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQN--EELKSRLC 372 Query: 609 ---KDINDQMDESFRELDMECALLDGEQ-----KSETTELMKEKEILDHLNRKIAELEKN 660 K + DE L M+ L + KS E EKE+L L +K+ +N Sbjct: 373 TLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRL-QKLHLQHQN 431 Query: 661 IVGEKTKEKVKLDAEREKLE----RLQELYS-----EQKTQLDNCPESMREQLQQQLKRD 711 + EK K + +E+L+ LQ L ++ + D + ++++Q + Sbjct: 432 VTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQAS 491 Query: 712 ADLLDVESKHFED----------LEFQQLEHESRLDEEK---ENLTQQLLREVAEYQRNI 758 D L+ KH D LE ++L+ + E+K N LL + E Q Sbjct: 492 KDELE-RQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKY 550 Query: 759 VSRKEKISALKKQANHIVQQAQR---EQDHFVKEKNNLIMMLQR------------EKEN 803 + ++++ L+ + +++ +R EQ +E + L + L + + E+ Sbjct: 551 KASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLED 610 Query: 804 LCNLEKKYSSLSGG-KGFPVNPNTLKEGYISVNE----INEPCGNSTNLSPSTQFPADAD 858 LC L+ Y + K N + + + + ++E E +P A + Sbjct: 611 LCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSS 670 Query: 859 AVATEPATAVLASQPQSKEHFRSLEERKK---QHKEGLYLSDTLPRKKTTSSISPHFSSA 915 + +L Q Q+ + + K+ Q ++G L + RK+ + + Sbjct: 671 KCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEE---RKRLQADLQLCLEEM 727 Query: 916 TMGRSITPKAHLPL-GQSNSCGSVLPPS------LAAMAKDSESRRMLRGYNHQQMSEGH 968 + + +P + L S GS++P + D+ES + Y Q S Sbjct: 728 QLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNES--YYKSYTSTQTSSKS 785 Query: 969 RQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSAS 1028 KS Y+ + S S Y S+ +S +++ S +S C +SS + Sbjct: 786 FLKS--YDSSTSASEAYGKSYCTTSNS-------SITYKKSYGSTSSSDTCQKSFVSSCT 836 Query: 1029 TSNIARIEEMERL----------------LKQAHAEKTRLLESREREMEAKKRALEEE-- 1070 A E+MER + Q E+ L+ + ++ AK++ L+EE Sbjct: 837 DEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELD 896 Query: 1071 ------KRRREILEKRLQEETSQRQKLIEKEVKIRERQ 1102 K E LEK + + + + ++ E + K+RE Q Sbjct: 897 ACEREFKECMECLEKPMAPQ-NDKNEIKELQTKLRELQ 933 Score = 38.5 bits (88), Expect = 0.041 Identities = 67/291 (23%), Positives = 117/291 (40%), Gaps = 32/291 (10%) Query: 428 YHRRQREERLREQEMERL--ERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEK 485 Y Q ++ L +QE RL ER+RL+ L LC +E++Q + + Sbjct: 692 YDAGQAKQELLQQEQGRLLEERKRLQADLQLC---------------LEEMQLLQVQSPS 736 Query: 486 LQLSDEESVFEEALMSPDTRYRCHRKDSLPDAD---LASCGSLSQSSASFFT--PRSTRN 540 +++S E M P D+ D + S S SS SF ST Sbjct: 737 IKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSA 796 Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600 E T S T+ K+ +S K+ ++ E ME +++ Sbjct: 797 SEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKV 856 Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL----MKEKEILDHLNRKIA- 655 L +L Q ++ + E +L + L +QK EL + KE ++ L + +A Sbjct: 857 LIKL-QAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAP 915 Query: 656 ELEKNIVGE---KTKE-KVKLDAEREKLERLQELYSEQKTQLDNCPESMRE 702 + +KN + E K +E +++ A ++ RL + + + QL C E +R+ Sbjct: 916 QNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQ 966 >gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] Length = 1411 Score = 65.5 bits (158), Expect = 3e-10 Identities = 156/764 (20%), Positives = 300/764 (39%), Gaps = 108/764 (14%) Query: 386 GSVEFDEADLESLRQASGTPQPA---LRERKSSISSISGR--DDLMDYHRRQREERLREQ 440 G V A+L+SL Q Q +++ K + + ++ D + EER + Sbjct: 128 GLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE 187 Query: 441 EMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 500 E+ + E + + L +EDV + KEL ++Q LM Sbjct: 188 AAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQ----------TLM 237 Query: 501 SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPK 560 T R + L D C L AS S +L S+L + P + + Sbjct: 238 DNMTLERERESEKLKD----ECKKLQSQYASSEATIS----QLRSELAKGPQEVAVYVQE 289 Query: 561 ASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFR 620 S ++ L + + ++E +E + T++ +N E + +K + + Sbjct: 290 LQKLKSSVNELTQKNQTLTENLLKKE---QDYTKLEEKHNEESVSKK------NIQATLH 340 Query: 621 ELDMECALLDGEQKSETT-------ELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLD 673 + D++C L + T EL ++ E L +++E+E K + K +L Sbjct: 341 QKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFK-QLQ 399 Query: 674 AEREKLER--------LQELYS---EQKTQLDNCPESMREQLQQQLKRDADLLDVESKHF 722 +RE+ E+ + +L+S E + QL ++EQ Q ++ L+D E + Sbjct: 400 QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEK---LMDKEQQ-V 455 Query: 723 EDLEFQQLEHESRLDEEKENLT--QQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780 DL+ + E +L E+ N T Q L + + + + ++ +A ++A + ++Q Sbjct: 456 ADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVL 515 Query: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKK----YSSLSGGKGFPVNPNTLKEGYISVNE 836 R+ ++ NL +LQ+ KEN+ LEK+ Y+ + G+G N L+E ++ E Sbjct: 516 RQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQE 575 Query: 837 INEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEER----------- 885 T L+ + +++ A E + Q K H R+ ++R Sbjct: 576 ------QVTQLTEKLKNQSESHKQAQENLHDQVQEQ---KAHLRAAQDRVLSLETSVNEL 626 Query: 886 ---KKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPS 942 + KE + D + KT +S +A + + HL Q+ Sbjct: 627 NSQLNESKEKVSQLDIQIKAKTELLLSA--EAAKTAQRADLQNHLDTAQN---------- 674 Query: 943 LAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFD 1002 A K E ++ + Q++ + K E ++ S Y + + ++ Sbjct: 675 -ALQDKQQELNKITTQLD--QVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQ 731 Query: 1003 TLSLDSSDSMETSIS-ACSPDNISSASTSNIARIEEMERLLKQAHAEK-----TRL-LES 1055 L+ +DS+E S + ++ N L KQ EK TRL L+ Sbjct: 732 IKKLE-ADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQK 790 Query: 1056 REREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIR 1099 + +E+ K+ L +++ ++IL++ E SQ K+ +E+ R Sbjct: 791 KSEALESIKQKLTKQEEEKQILKQDF-ETLSQETKIQHEELNNR 833 Score = 65.5 bits (158), Expect = 3e-10 Identities = 142/703 (20%), Positives = 277/703 (39%), Gaps = 111/703 (15%) Query: 431 RQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQ-KINKELEKL-QL 488 +Q +E L +Q E+ R D LS T+V ++ ++N+ EK+ QL Sbjct: 592 KQAQENLHDQVQEQKAHLR-----------AAQDRVLSLETSVNELNSQLNESKEKVSQL 640 Query: 489 SDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLT 548 + E L+S + R D D A + Q +T+ D++ + L Sbjct: 641 DIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQ--NALQDKQQELNKITTQLDQVTAKLQ 698 Query: 549 RTPPPPSSTFPKASS-ESSYLSILPKTPEGISE----EQRSQELAAMEETRIVILNNLEE 603 S + YLS+ KT E + E S E+ A +E L +L++ Sbjct: 699 DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA---LQDLQQ 755 Query: 604 LKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVG 663 +Q D+ + E ++L+ME ++ S +L K+ E L+ + +K+ Sbjct: 756 QRQLNTDLELRATELSKQLEMEKEIVS----STRLDLQKKSEALESIKQKL--------- 802 Query: 664 EKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFE 723 TK++ + ++ E L + Q +L+N ++ +LQ+ +K + + L E Sbjct: 803 --TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK-VKMEKEALMTEL---- 855 Query: 724 DLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQ 783 S + ++ ++ L +E+++ K I L+K + Q Q + Sbjct: 856 ----------STVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM 905 Query: 784 DHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGN 843 ++ +KE+ L L++EKE L+ + +S+ + NTLK+ + E + GN Sbjct: 906 ENTLKEQKELKKSLEKEKEASHQLKLELNSMQ--EQLIQAQNTLKQ---NEKEEQQLQGN 960 Query: 844 STNLSPST-QFPADADAVATEPATAVL---------------ASQPQSKE---------H 878 L S+ Q +A+ E AVL A+Q + E + Sbjct: 961 INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020 Query: 879 FRSLEERKKQHKEGLY--LSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCG 936 + +E KQ + Y S+ L ++ S+ S + + +G N Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLS---LAQEDLISNRNQIGNQNKLI 1077 Query: 937 SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSY 996 L + A + +DS + QQ+ E + + + + +N Sbjct: 1078 QELKTAKATLEQDSAKK-------EQQLQERCKALQDIQKEKSLKEKELVNE-------- 1122 Query: 997 KDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESR 1056 K + + + E + + S I +++ ++LL Q E Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE-------L 1175 Query: 1057 EREMEAKKRALEEEKRRREILEKRL-QEETSQRQKLIEKEVKI 1098 + + ++ K A+E+EKR ++IL+ ++ +EE +++ IEKE K+ Sbjct: 1176 QGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKL 1218 Score = 60.1 bits (144), Expect = 1e-08 Identities = 94/447 (21%), Positives = 194/447 (43%), Gaps = 45/447 (10%) Query: 396 ESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLERQ-RLET 452 ES +QA ++E+K+ + + R ++ + +L E +++ +L+ Q + +T Sbjct: 589 ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKT 648 Query: 453 ILSLCAEYTKPDSR------LSTGTTV-----EDVQKINKELEKL--QLSDEE---SVFE 496 L L AE K R L T +++ KI +L+++ +L D++ S E Sbjct: 649 ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLE 708 Query: 497 EALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSS 556 L +Y SL G + + A ++++ ++ L DL + + Sbjct: 709 SHLKEYKEKYL-----SLEQKTEELEGQIKKLEADSLEVKASK-EQALQDLQQQRQLNTD 762 Query: 557 TFPKASSESSYLSI-----------LPKTPEGISEEQRSQELAAMEETRIVILNNLEELK 605 +A+ S L + L K E + E Q+L EE + ++ + E L Sbjct: 763 LELRATELSKQLEMEKEIVSSTRLDLQKKSEAL--ESIKQKLTKQEEEKQILKQDFETLS 820 Query: 606 QKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEK 665 Q+ K +++++ + E + E+++ TEL K+ L K+++ KN E Sbjct: 821 QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS----KVSDSLKNSKSEF 876 Query: 666 TKEKVKLDAEREKLERL-QELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFED 724 KE K A LE+ +EL + + Q++N + +E L++ L+++ + Sbjct: 877 EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE-LKKSLEKEKEASHQLKLELNS 935 Query: 725 LEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQD 784 ++ Q ++ ++ L ++ E QQL + E +++ +K++I AL+ + V Q ++ Sbjct: 936 MQEQLIQAQNTL-KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN 994 Query: 785 HFVKEKNNLIMMLQREKENLCNLEKKY 811 ++ L EKE + L+ Y Sbjct: 995 KLQQQLTQAAQELAAEKEKISVLQNNY 1021 Score = 54.3 bits (129), Expect = 7e-07 Identities = 106/537 (19%), Positives = 219/537 (40%), Gaps = 60/537 (11%) Query: 393 ADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE------ERLREQEMERLE 446 A L+ ++ + L+E K S+ + + ++ ++ E + +EQ ++ L+ Sbjct: 695 AKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQ 754 Query: 447 RQR-LETILSLCAEYTKPDSRLS---TGTTVEDVQKINKELEKLQLS-----DEESVFEE 497 +QR L T L L A + +T D+QK ++ LE ++ +E+ + ++ Sbjct: 755 QQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQ 814 Query: 498 AL--MSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPS 555 +S +T+ + ++ + + + T ST D+L S ++ + Sbjct: 815 DFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL-SKVSDSLKNSK 873 Query: 556 STFPKASSESSYLSI-LPKTPEGISEEQRSQELAAMEETRIVILNNLE-------ELKQK 607 S F K + + + L KT + + + + Q ++E + + +LE +LK + Sbjct: 874 SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK-ELKKSLEKEKEASHQLKLE 932 Query: 608 IKDINDQM---DESFRELDMECALLDG---EQKSETTELMKEKEILDHLNRKIAELEKNI 661 + + +Q+ + ++ + E L G E K + + K+ E L KIA L+K Sbjct: 933 LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG-ELKIAVLQKTE 991 Query: 662 VGEKTKEKV-----KLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLD 716 + K ++++ +L AE+EK+ LQ Y + + + + L DL Sbjct: 992 LENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKS 1051 Query: 717 VESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIV 776 VE K L + L + L Q+L A +++ +++++ K I Sbjct: 1052 VEEK--LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQ 1109 Query: 777 QQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNE 836 ++ ++ V EK+ L + +E C EK+ + L N S+ E Sbjct: 1110 KEKSLKEKELVNEKSKLAEI----EEIKCRQEKEITKL--------NEELKSHKLESIKE 1157 Query: 837 INEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGL 893 I TNL + Q A ++ A+ Q K + + L+++ K+ +E L Sbjct: 1158 I-------TNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL 1207 Score = 53.9 bits (128), Expect = 9e-07 Identities = 52/207 (25%), Positives = 102/207 (49%), Gaps = 23/207 (11%) Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660 ++ELK + + ++L C L QK ++ +KEKE+++ + K+AE+E+ Sbjct: 1077 IQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKS---LKEKELVNEKS-KLAEIEE- 1131 Query: 661 IVGEKTKEKVKLDAERE--KLERLQELYS---------EQKTQLDNCPESMREQLQQQLK 709 I + KE KL+ E + KLE ++E+ + +QK +L +S++ ++Q+ + Sbjct: 1132 IKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKR 1191 Query: 710 RDADLLDVESKHFEDLEFQQLEHESRLD---EEKENLTQQLLREVAEYQRNIVSRKEKIS 766 L D K E+L+ + +E E++L +EKE ++ A+ I + E + Sbjct: 1192 NQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLG 1251 Query: 767 ALKKQANHIVQQAQREQDHFVKEKNNL 793 +KK+ Q +QR K+ ++L Sbjct: 1252 TVKKE----WQSSQRRVSELEKQTDDL 1274 Score = 50.1 bits (118), Expect = 1e-05 Identities = 128/710 (18%), Positives = 269/710 (37%), Gaps = 78/710 (10%) Query: 474 EDVQKINKELEKLQLS-DEESVFEEALMSPDTRYR-CHRKDSLPDADLASCGSLSQSSAS 531 +DV + +E++ LQ S EE + E L +Y+ ++++ PD + + QS Sbjct: 83 DDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQ 142 Query: 532 FFTPRSTRNDEL--LSDLTRTPPPPSSTF-----PKASSESSYLSILPKTPEGISEEQRS 584 T N + + DL +T K E S + ++EE Sbjct: 143 QLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNK 202 Query: 585 QELAAME-ETRIVILNNLEE---LKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640 + + +T ++ +E+ LK+++ + MD E + E L E K ++ Sbjct: 203 EATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQY 262 Query: 641 MKEKEILDHLNRKIAELEKNI---VGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP 697 + + L ++A+ + + V E K K ++ +K + L E +++ Sbjct: 263 ASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLE 322 Query: 698 ESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDE-----------EKENLTQQ 746 E E+ + A L H +DL+ QQL+ E EK TQ+ Sbjct: 323 EKHNEESVSKKNIQATL------HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK 376 Query: 747 LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCN 806 L E++E + K LK + + QQ + ++ H ++ ++ + + + E Sbjct: 377 LKEELSEVET-------KYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ 429 Query: 807 LEKKYSSLSGGKGFPVNPNTLKEGYIS---------VNEINEPCGNSTNLS----PSTQF 853 L + + L + KE ++ ++ E NST L + Q Sbjct: 430 LGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ 489 Query: 854 PADADAVATEPATAVLASQPQSKEHFRSL--EERKKQHKEGLYLSDTLPRKKTTSSISPH 911 + A+ + +Q ++ R + +++K Q+ E L Sbjct: 490 HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDL 549 Query: 912 FSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQK 971 ++ G T + ++++ + + SES + + H Q+ E Sbjct: 550 YAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHL 609 Query: 972 SEFYNRTAS-ESNVYLNSFHYPDHSYKDQAFD------TLSLDSSDSMETSISACSPDNI 1024 +R S E++V + + K D T L S+++ +T+ A +++ Sbjct: 610 RAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHL 669 Query: 1025 SSASTSNIARIEEMERLLKQAHAEKTRL---------LESREREMEAKKRALEEEKRRRE 1075 +A + + +E+ ++ Q +L LES +E + K +LE++ E Sbjct: 670 DTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELE 729 Query: 1076 ILEKRLQEETSQRQKLIEKEVKIRERQR-------AQARPLTRYLPVRKE 1118 K+L+ ++ + + E+ ++ ++QR +A L++ L + KE Sbjct: 730 GQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKE 779 >gi|41872583 Rho-associated, coiled-coil containing protein kinase 2 [Homo sapiens] Length = 1388 Score = 65.1 bits (157), Expect = 4e-10 Identities = 117/562 (20%), Positives = 238/562 (42%), Gaps = 59/562 (10%) Query: 584 SQELAAMEETRIVILNNLEELKQKIKDINDQ---MDESFRELDMECALLDGEQKSETTEL 640 S A + +T+ +++L+ +D+ D+ ++ + +L+ E L +SE + Sbjct: 575 SDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDR 634 Query: 641 MKEKEILDHLNRKIAELEKNIV-GEKTKEKVKLDAEREKLERLQELYSEQKT-------Q 692 EI++ L +I LE+++ G+ KV+L+ +R+ ER +L E+ Q Sbjct: 635 THGSEIINDLQGRICGLEEDLKNGKILLAKVELE-KRQLQERFTDLEKEKSNMEIDMTYQ 693 Query: 693 LDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVA 752 L +S+ ++ + A L D ++K +E +E + + E+ + EK+ L ++ L++ Sbjct: 694 LKVIQQSLEQEEAEHKATKARLAD-KNKIYESIE--EAKSEAMKEMEKKLLEERTLKQKV 750 Query: 753 EYQRNIVSRKEKISALK----KQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 808 E N++ EK +L KQ+ + + +++D ++ NL + +++E + C + Sbjct: 751 E---NLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQ 807 Query: 809 KKYSSLSGGKGFPVNPNTLKEGYISVN-EINEPCGNSTNLSPST----QFPADADAVATE 863 + NTLK + E N NL + DAD E Sbjct: 808 NDLKMQTQ------QVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKE 861 Query: 864 PATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITP 923 + A Q S + + E K++ +E L L +KK +A + ++T Sbjct: 862 LQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTK 921 Query: 924 KAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTAS--- 980 L +S + D E ++++ ++M H+Q+ + T + Sbjct: 922 ADSEQLARSIA---------EEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLE 972 Query: 981 ESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-- 1038 E+N L S + K++ + L ++ +S + IS+A+ A+ E+ Sbjct: 973 ETNRTLTSDVANLANEKEELNNKLK-----DVQEQLSRLKDEEISAAAIK--AQFEKQLL 1025 Query: 1039 -ERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEET-SQRQKLIEKEV 1096 ER LK K + +R+ E KR + + RR+E ++L E S+R+KL ++ + Sbjct: 1026 TERTLKTQAVNKLAEIMNRK---EPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMI 1082 Query: 1097 KIRERQRAQARPLTRYLPVRKE 1118 K ++ + +R E Sbjct: 1083 KYQKELNEMQAQIAEESQIRIE 1104 Score = 52.0 bits (123), Expect = 4e-06 Identities = 67/277 (24%), Positives = 119/277 (42%), Gaps = 34/277 (12%) Query: 564 ESSYLSILPKTPEGISEEQRSQE--------LAAMEETRIVILNNLEELKQKIKDINDQM 615 E+ LS P E S + R E L +EE + EEL+QK K +N ++ Sbjct: 418 ENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRL 477 Query: 616 DESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAE 675 +++ +EL+ E L + S +L +EK +L H N + + +K + +++ Sbjct: 478 EKTAKELEEEITLRKSVE-SALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSL 536 Query: 676 REKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDL---------E 726 +++LE L +++ Q QLQ+QL LL ES L + Sbjct: 537 KDQLEDL-----KKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQ 591 Query: 727 FQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ-----R 781 QQLE +R ++K L + ++ + N+ S E + + I+ Q Sbjct: 592 IQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGL 651 Query: 782 EQDHFVKEKNNLIMMLQREK----ENLCNLEKKYSSL 814 E+D +K L+ ++ EK E +LEK+ S++ Sbjct: 652 EED--LKNGKILLAKVELEKRQLQERFTDLEKEKSNM 686 Score = 43.9 bits (102), Expect = 0.001 Identities = 59/264 (22%), Positives = 120/264 (45%), Gaps = 31/264 (11%) Query: 578 ISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSET 637 +SE+Q QE + E ++ + EL+++ +D + QM E +L+ E K++ Sbjct: 822 MSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAE-QYFSTLYKTQV 880 Query: 638 TELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLD-----AEREKL------ERLQELY 686 EL +E E L +++ + ++ + E+ +L+ A+ E+L E+ +L Sbjct: 881 RELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLE 940 Query: 687 SEQKTQLDNCPESMREQLQQQLKRDADLLDVE------SKHFEDLEFQQLEHESRLDEEK 740 E+ + E M Q+ ++DA + +E + +L ++ E ++L + + Sbjct: 941 KEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQ 1000 Query: 741 ENLTQQLLREV------AEYQRNIVS-RKEKISALKKQAN--HIVQQAQREQDHFV---- 787 E L++ E+ A++++ +++ R K A+ K A + + +R D V Sbjct: 1001 EQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKE 1060 Query: 788 KEKNNLIMMLQREKENLCNLEKKY 811 KE L M L+ E+E L KY Sbjct: 1061 KENRKLHMELKSEREKLTQQMIKY 1084 >gi|71061468 centromere protein E [Homo sapiens] Length = 2701 Score = 65.1 bits (157), Expect = 4e-10 Identities = 158/761 (20%), Positives = 311/761 (40%), Gaps = 112/761 (14%) Query: 406 QPALRERKSSISS----ISGRDDLMDYHRRQREE---RLREQEM-----ERLERQRLETI 453 Q + E + S+S I DL H + +EE EQE+ E E Q Sbjct: 1248 QETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNE 1307 Query: 454 LSLCAEYTKPDSRLSTGTTVEDVQKINKEL-EKLQLSDEE-----------SVFEEALMS 501 L L E S TT+ ++ L EK Q S EE +EAL Sbjct: 1308 LELLTE----QSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEV 1363 Query: 502 PDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKA 561 + + H +++L A + S + S + + +++S++ + P S+ + Sbjct: 1364 KHDQLKEHIRETL--AKIQESQSKQEQSLNM-KEKDNETTKIVSEMEQFKPKDSALL-RI 1419 Query: 562 SSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRE 621 E LS + + E + A E+ ++L+ L++ ++ +DQ+ E+ +E Sbjct: 1420 EIEMLGLS------KRLQESHDEMKSVAKEK------DDLQRLQEVLQSESDQLKENIKE 1467 Query: 622 LDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLE- 680 + + + E K L +++E ++ L ++E E I T +K +L+A +KL+ Sbjct: 1468 IVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEI---STIQK-QLEAINDKLQN 1523 Query: 681 RLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEK 740 ++QE+Y E++ Q + S ++ +LK+ + + + +E + LE +RL E + Sbjct: 1524 KIQEIY-EKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQ 1582 Query: 741 ENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE 800 E + Q +++E E +R + + + LK+ IV + + Q+ KE L M E Sbjct: 1583 EEI-QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQE---KEYQFLKMTAVNE 1638 Query: 801 -KENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADA 859 +E +C +E K +N ++ I + +I NL + D Sbjct: 1639 TQEKMCEIEHLKEQFETQK---LNLENIETENIRLTQILH-----ENLEEMRSVTKERDD 1690 Query: 860 VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYL--------SDTLPR-----KKTTS 906 + + T + + Q KE+ R R + +E L + +T+ + + T+ Sbjct: 1691 LRSVEET-LKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTN 1749 Query: 907 SIS------PHFSSATMGRSITPK-----AHLPLGQSNSCGSVL-------PPSLAAMAK 948 IS H + A + + + AH+ L + L L+ M K Sbjct: 1750 EISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQK 1809 Query: 949 DSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDS 1008 D E+ Q++ Q + +E+ ++ KDQ +L+L Sbjct: 1810 DLENSNAKLQEKIQELKANEHQLITL-KKDVNETQKKVSEMEQLKKQIKDQ---SLTLSK 1865 Query: 1009 SDSMETSISACSPDNISSAST-----SNIARIEEMERLLKQAHAEKTRLLESREREMEAK 1063 + +++ +N+ + N+ R+EE +L E+ +L ES + E +A+ Sbjct: 1866 LEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKL------ERDQLKESLQ-ETKAR 1918 Query: 1064 KRALEEEKRRREILEKRLQEETSQ-RQKLIEKEVKIRERQR 1103 +++E + +L K +E + R+K+ EK ++I + Q+ Sbjct: 1919 DLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQK 1959 Score = 58.5 bits (140), Expect = 4e-08 Identities = 116/550 (21%), Positives = 228/550 (41%), Gaps = 74/550 (13%) Query: 592 ETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLD--GEQKSETTELM---KEKEI 646 +T+ + N LE LKQ + IN + E+ + + GE K E + M +K+ Sbjct: 961 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD 1020 Query: 647 LDHLNRKI--AELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQL-----DNCPES 699 L+ N + A+++ N + E+ ++ L E+ +L+++ E +K QL +N + Sbjct: 1021 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT 1080 Query: 700 MREQ-----LQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEY 754 + Q L +LK+ +++ E H E + RL E +E L ++ +++ E Sbjct: 1081 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKS-QQLQEK 1139 Query: 755 QRNIVSRKEKISALKKQANHI------VQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 808 Q+ +++ +E++S ++K+ N I ++ + +H E+ L L E + ++ Sbjct: 1140 QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSIT 1199 Query: 809 KKYSSLSG-GKGFPVNPNTLKEGYISVNEINEPCGNST---------NLSPSTQFPADAD 858 K+ L K F + L+ GYI EI E G T +L + + Sbjct: 1200 KERKVLKELQKSFETERDHLR-GYI--REI-EATGLQTKEELKIAHIHLKEHQETIDELR 1255 Query: 859 AVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMG 918 +E ++ +Q K H + EE H+E + LP K S + TM Sbjct: 1256 RSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEE----QELLPNVKEVSE-----TQETMN 1306 Query: 919 RSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRT 978 + L QS + S +LA + E R+ Q+ E E + T Sbjct: 1307 -----ELELLTEQSTTKDST---TLARI----EMERLRLNEKFQESQE------EIKSLT 1348 Query: 979 ASESNVYL--NSFHYPDHSYKDQAFDTLSL--DSSDSMETSISACSPDNISSASTSNIAR 1034 N+ + K+ +TL+ +S E S++ DN ++ S + + Sbjct: 1349 KERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ 1408 Query: 1035 IEEMERLLKQAHAE----KTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1090 + + L + E RL ES + EM++ + ++ +R +E+L+ + ++ Sbjct: 1409 FKPKDSALLRIEIEMLGLSKRLQESHD-EMKSVAKEKDDLQRLQEVLQSESDQLKENIKE 1467 Query: 1091 LIEKEVKIRE 1100 ++ K ++ E Sbjct: 1468 IVAKHLETEE 1477 Score = 55.5 bits (132), Expect = 3e-07 Identities = 136/743 (18%), Positives = 302/743 (40%), Gaps = 104/743 (13%) Query: 432 QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQK-----------IN 480 + E + +E +E +E +RLE L Y + S ++++QK Sbjct: 1164 KNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYI 1223 Query: 481 KELEK--LQLSDEESVFEEALMS-PDTRYRCHRKDSLPDADLASCGSLSQSSASF--FTP 535 +E+E LQ +E + L +T R S A + + L +S P Sbjct: 1224 REIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIP 1283 Query: 536 RSTRNDELLSDLTRTPPPPSS-------TFPKASSESSYLSILPKTPEGISE--EQRSQE 586 ELL ++ + T + +S+ L+ + ++E ++ +E Sbjct: 1284 VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEE 1343 Query: 587 LAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEI 646 + ++ + R +NL+ +K+ ++ +DQ+ E RE + + + K E + MKEK+ Sbjct: 1344 IKSLTKER----DNLKTIKEALEVKHDQLKEHIRE--TLAKIQESQSKQEQSLNMKEKD- 1396 Query: 647 LDHLNRKIAELEKNIVGEKTKEKVKLDAEREKL---ERLQELYSEQKTQLDNCPESMREQ 703 + + ++E+E+ K K+ L E E L +RLQE + E K+ + R Sbjct: 1397 -NETTKIVSEMEQ----FKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQR-- 1449 Query: 704 LQQQLKRDADLL-----DVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI 758 LQ+ L+ ++D L ++ +KH E E ++ H +E+E +L ++E + I Sbjct: 1450 LQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCL--KEQEETINELRVNLSEKETEI 1507 Query: 759 VSRKEKISALKKQANHIVQQAQREQDHF-------VKEKNNLIMMLQREKE----NLCNL 807 + ++++ A+ + + +Q+ +++ F V+EK N + + ++ L ++ Sbjct: 1508 STIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSI 1567 Query: 808 EKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATA 867 E K L+ N L+E + + + + + Q D E Sbjct: 1568 ESKMLELT---------NRLQESQEEIQIMIKEKEEMKRVQEALQIERDQ---LKENTKE 1615 Query: 868 VLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHL 927 ++A +S +E++ Q + +++T + + F + + ++ Sbjct: 1616 IVAKMKES-------QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENI 1668 Query: 928 PLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTA----SESN 983 L Q +L +L M ++ R LR E + K + Sbjct: 1669 RLTQ------ILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEE 1722 Query: 984 VYLNSFHYPDHSYK-DQAFDTLSLDSSD------SMETSISACSPDNISSASTSNIARI- 1035 + + H +H D+ +S +++ +E S A ++ IA + Sbjct: 1723 LKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMH 1782 Query: 1036 --EEMERL--LKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR---LQEETSQR 1088 E+ E + L+ +EKT L + ++++E L+E+ + + E + L+++ ++ Sbjct: 1783 LKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNET 1842 Query: 1089 QKLIEKEVKIRERQRAQARPLTR 1111 QK + + +++++ + Q+ L++ Sbjct: 1843 QKKVSEMEQLKKQIKDQSLTLSK 1865 Score = 53.9 bits (128), Expect = 9e-07 Identities = 164/829 (19%), Positives = 308/829 (37%), Gaps = 139/829 (16%) Query: 343 LASTSSCASDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEA--DLESLRQ 400 + S S S+ D S + NP+ LL E+ + ++D D E LR Sbjct: 465 VCSESDVFSNTLDTLSEIEWNPATKLLNQEN-----IESELNSLRADYDNLVLDYEQLRT 519 Query: 401 ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEY 460 + L+E+ +DL ++ +R+ + ++QEM+ + L AE Sbjct: 520 EKEEMELKLKEK----------NDLDEFEALERKTK-KDQEMQLIHEISNLKNLVKHAEV 568 Query: 461 TKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLA 520 D + VE +++ +++KLQ + E M D Y L Sbjct: 569 YNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKM--DLSY-----------SLE 615 Query: 521 SCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISE 580 S Q + F + D A ES++L E + Sbjct: 616 SIEDPKQMKQTLFDAETVALD-------------------AKRESAFLR-----SENLEL 651 Query: 581 EQRSQELAA----MEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE-QKS 635 +++ +ELA ME + + LE K+ D+ ++ +F E+ +L+DG+ K Sbjct: 652 KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKD 711 Query: 636 ETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKV-------KLDAEREKLERLQELYSE 688 L E +I D E+E+N E +E+V L +E E+L + + SE Sbjct: 712 LLCNLELEGKITDLQKELNKEVEEN---EALREEVILLSELKSLPSEVERLRKEIQDKSE 768 Query: 689 QKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENL----- 743 + + + + + ++ + R LL+ K +DL Q ++S D+E +N Sbjct: 769 ELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKS-TDQEFQNFKTLHM 827 Query: 744 ------------TQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKN 791 +++ +E+ + + ALK + ++ Q+ Q E+ V+E+ Sbjct: 828 DFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQ-EKTREVQERL 886 Query: 792 NLIMMLQREKEN----LCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNL 847 N + L+ + EN L +E++ + ++ L++ V + + + L Sbjct: 887 NEMEQLKEQLENRDSTLQTVEREKTLIT---------EKLQQTLEEVKTLTQEKDDLKQL 937 Query: 848 SPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGL---------YLSDT 898 S Q D + ++E R+ E KQH+E + +S Sbjct: 938 QESLQIERDQ---LKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRN 994 Query: 899 LPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRG 958 L ++ T F +G I K L + +L A KD+E R Sbjct: 995 LHMEENTGETKDEFQQKMVG--IDKKQDLEAKNTQ--------TLTADVKDNEIIEQQRK 1044 Query: 959 Y--------NHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSD 1010 QQM E + E +T + N+ + + + D L Sbjct: 1045 IFSLIQEKNELQQMLESVIAEKE-QLKTDLKENIEMTIENQEELRLLG---DELKKQQEI 1100 Query: 1011 SMETSISACSPDNISSASTSNIARIEE-MERLLKQAHAEKTRLLESREREMEAKKRALEE 1069 + A + S + +A +EE ++ +Q ++ +LL +E E +K+ E Sbjct: 1101 VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1160 Query: 1070 EKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKE 1118 E + E+ K L E + ++L E K+ E + + +T+ V KE Sbjct: 1161 ENLKNELKNKELTLEHMETERL-ELAQKLNENYE-EVKSITKERKVLKE 1207 Score = 49.3 bits (116), Expect = 2e-05 Identities = 96/469 (20%), Positives = 195/469 (41%), Gaps = 55/469 (11%) Query: 389 EFDEADLESLRQASGTPQPALRERKSSISSISG-RDDL------MDYHRRQREERLREQE 441 E + +LE++ + L E + S++ RDDL + R Q +E LRE Sbjct: 1654 ETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETI 1713 Query: 442 MERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMS 501 LE+Q I+ + + + G E +I+ + L+ S++ ++ + Sbjct: 1714 TRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ 1773 Query: 502 PDTRY-RCHRKD-------------------SLPDADLASCGSLSQSSASFFTPRSTRND 541 + R H K+ S DL + + Q + Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLI 1833 Query: 542 ELLSDLTRTPPPPSSTFP-KASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVIL-- 598 L D+ T S K + L++ E ++ Q+ E +EE + V+ Sbjct: 1834 TLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHE--NLEEMKSVMKER 1891 Query: 599 NNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAE-- 656 +NL +++ +K DQ+ ES +E + E K+ + KE +D L KI+E Sbjct: 1892 DNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKT 1951 Query: 657 -----LEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRD 711 ++K++ +K+K++++ + + + LQ L ++ + + + EQL++Q + Sbjct: 1952 IQISDIQKDL--DKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQF--E 2007 Query: 712 ADLLDVESKHFEDLEFQQLEHESRLDE----EKENLTQQLLREVAEYQRN--IVSRKEKI 765 A L ++S ++ + + HES L+E KE + ++E + +R+ I + +E I Sbjct: 2008 AQNLSMQSVRMDNFQLTKKLHES-LEEIRIVAKERDELRRIKESLKMERDQFIATLREMI 2066 Query: 766 SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 814 + + + NH Q + E+ + +L L+ + + L K+YS + Sbjct: 2067 A--RDRQNH---QVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEM 2110 Score = 48.5 bits (114), Expect = 4e-05 Identities = 138/657 (21%), Positives = 246/657 (37%), Gaps = 141/657 (21%) Query: 571 LPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECAL-- 628 L K E +S E R+Q AME+ ++ L ++L QK++ N++++ R L +L Sbjct: 355 LKKQLEEVSLETRAQ---AMEKDQLAQLLEEKDLLQKVQ--NEKIENLTRMLVTSSSLTL 409 Query: 629 ---LDGEQKSETT------ELMKEKEILDHLN------RKIAELEKNIVGEKTKEKV-KL 672 L ++K T MK D N K +L N++ E + + Sbjct: 410 QQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSES 469 Query: 673 DAEREKLERLQELYSEQKTQLDNCPESMREQLQ-------------QQLKRDADLLDVES 719 D L+ L E+ T+L N E++ +L +QL+ + + ++++ Sbjct: 470 DVFSNTLDTLSEIEWNPATKLLN-QENIESELNSLRADYDNLVLDYEQLRTEKEEMELKL 528 Query: 720 KHFEDL-EFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ 778 K DL EF+ LE +++ D+E QL+ E++ +N+V E N ++ Sbjct: 529 KEKNDLDEFEALERKTKKDQE-----MQLIHEISNL-KNLVKHAEVY-------NQDLEN 575 Query: 779 AQREQDHFVKEKNNLIMMLQR--EKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNE 836 + ++EK + I LQ + + L N++ S S+ Sbjct: 576 ELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLS-------------------YSLES 616 Query: 837 INEPCGNSTNLSPSTQFPADADAVATEPATAVLASQP-QSKEHFRSLEERKKQHKEG--L 893 I +P T F A+ A+ + +A L S+ + KE + L KQ + L Sbjct: 617 IEDP-----KQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQL 671 Query: 894 YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNS---CGSVLPPSLAAMAKD- 949 Y S +KK + SA IT L G+ C L + + K+ Sbjct: 672 YQSQLEAKKKMQVDLEKELQSAF--NEITKLTSLIDGKVPKDLLCNLELEGKITDLQKEL 729 Query: 950 ------------------------SESRRMLRGYN------HQQMSEGHRQKSEFYNRTA 979 SE R+ + H SE + SE ++ + Sbjct: 730 NKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKES 789 Query: 980 -----------SESNVYLNSFHYPDHSYKDQAFDTLSLD----------SSDSMETSISA 1018 ++ ++ +Y + Q F TL +D ++ M I Sbjct: 790 RVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVN 849 Query: 1019 CSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILE 1078 S + + S++ ++ Q EKTR ++ R EME K LE + +E Sbjct: 850 LSKE--AQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVE 907 Query: 1079 KRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDT 1135 + T + Q+ +E EVK +++ + L L + ++ H +T NIDT Sbjct: 908 REKTLITEKLQQTLE-EVKTLTQEKDDLKQLQESLQIERDQLKSDIH-DTVNMNIDT 962 Score = 44.7 bits (104), Expect = 6e-04 Identities = 76/384 (19%), Positives = 159/384 (41%), Gaps = 47/384 (12%) Query: 440 QEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEAL 499 QE L+ Q LE++++ E K D + + T+E+ E+L+L +E ++ + Sbjct: 1050 QEKNELQ-QMLESVIAE-KEQLKTDLKENIEMTIENQ-------EELRLLGDELKKQQEI 1100 Query: 500 MSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFP 559 ++ + + ++ L +C L++ +E L + ++ Sbjct: 1101 VAQEKNHAIKKEGELS----RTCDRLAEV------------EEKLKEKSQQLQEKQQQLL 1144 Query: 560 KASSESSYLSILPKTPEGISEEQRSQELAA--MEETRIVILNNLEELKQKIKDINDQ--- 614 E S + E + E +++EL ME R+ + L E +++K I + Sbjct: 1145 NVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKV 1204 Query: 615 MDESFRELDMECALLDGE-QKSETTELMKEKEI-LDHLNRK-----IAELEKNIVGEKTK 667 + E + + E L G ++ E T L ++E+ + H++ K I EL ++ V EKT Sbjct: 1205 LKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRS-VSEKTA 1263 Query: 668 EKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEF 727 + + + +LQE + + P Q+ + +LL +S + Sbjct: 1264 QIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTL 1323 Query: 728 QQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ---------Q 778 ++E E EK +Q+ ++ + + + N+ + KE + Q ++ Q Sbjct: 1324 ARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQ 1383 Query: 779 AQREQDHFVKEKNNLIMMLQREKE 802 +++EQ +KEK+N + E E Sbjct: 1384 SKQEQSLNMKEKDNETTKIVSEME 1407 >gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo sapiens] Length = 1133 Score = 64.3 bits (155), Expect = 7e-10 Identities = 152/739 (20%), Positives = 297/739 (40%), Gaps = 86/739 (11%) Query: 429 HRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQL 488 H Q + ++ ++ ++ + IL C + KP S G ED L + L Sbjct: 23 HSFQGPKNMKHRQQDKDSPSESDVILP-CPKAEKPHS--GNGHQAED-------LSRDDL 72 Query: 489 SDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLT 548 S+ E L + D + + + DLA L ++ F TP+ ++L L Sbjct: 73 LFLLSILEGELQARDEVIGILKAEKM---DLA----LLEAQYGFVTPK-----KVLEALQ 120 Query: 549 RTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS--QELAAMEETRIVILNNLEELKQ 606 R ST + ++ L K E E R +L E++R + LEE K+ Sbjct: 121 RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180 Query: 607 KIKDINDQMDESFRELDMEC----ALLDGEQKS-ETTELMKEKEI--LDHLNRKIAELEK 659 K K+ ++ DE L+ EC L+D E KS E E KEK + L K+ Sbjct: 181 KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240 Query: 660 NIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVES 719 +V E+ + +L +R+K++ L E T+L ++E+ Q+ + + +L + Sbjct: 241 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300 Query: 720 KHFEDLE--FQQLEHESRLDEEKENLTQQL------LREVAEYQRNIVSRKEKISALKKQ 771 K +D + +L +E D + L Q+L + E+ E R++ +E++ +K++ Sbjct: 301 KFHQDQDTIMAKLTNE---DSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEK 357 Query: 772 ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS--------GGKGFPVN 823 + + V+E ++ ++ + E L +E++ L+ K F + Sbjct: 358 ISK-GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLE 416 Query: 824 PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE 883 L + +++ ++ + S S + + + + T+ + L S + ++E Sbjct: 417 VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIE 476 Query: 884 ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 943 R + K L + L + KT + + TM + K L ++S V + Sbjct: 477 SRLE--KTEFTLKEDLTKLKTLTVMFVD-ERKTMSEKL-KKTEDKLQAASSQLQVEQNKV 532 Query: 944 AAMAKD--SESRRMLRGYN--HQQMSEGHRQKSEFYNRTASES----------NVYLNSF 989 + + E++R L+ ++M +++ + N+ +E N+ N Sbjct: 533 TTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRL 592 Query: 990 HYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEK 1049 + KD + L+ DS S +A +N S +E ++ LK A + Sbjct: 593 QSLEAIEKDFLKNKLNQDSG----KSTTALHQENNKIKELSQ--EVERLKLKLKDMKAIE 646 Query: 1050 TRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQ--RQKLIEKE--------VKIR 1099 L+++ E E E +R E+ + + L K L+ + + KL EK K Sbjct: 647 DDLMKT-EDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRL 705 Query: 1100 ERQRAQARPLTRYLPVRKE 1118 + + A++ L+R + KE Sbjct: 706 QEEEAKSGHLSREVDALKE 724 >gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo sapiens] Length = 1135 Score = 64.3 bits (155), Expect = 7e-10 Identities = 152/739 (20%), Positives = 297/739 (40%), Gaps = 86/739 (11%) Query: 429 HRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQL 488 H Q + ++ ++ ++ + IL C + KP S G ED L + L Sbjct: 23 HSFQGPKNMKHRQQDKDSPSESDVILP-CPKAEKPHS--GNGHQAED-------LSRDDL 72 Query: 489 SDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLT 548 S+ E L + D + + + DLA L ++ F TP+ ++L L Sbjct: 73 LFLLSILEGELQARDEVIGILKAEKM---DLA----LLEAQYGFVTPK-----KVLEALQ 120 Query: 549 RTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS--QELAAMEETRIVILNNLEELKQ 606 R ST + ++ L K E E R +L E++R + LEE K+ Sbjct: 121 RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180 Query: 607 KIKDINDQMDESFRELDMEC----ALLDGEQKS-ETTELMKEKEI--LDHLNRKIAELEK 659 K K+ ++ DE L+ EC L+D E KS E E KEK + L K+ Sbjct: 181 KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240 Query: 660 NIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVES 719 +V E+ + +L +R+K++ L E T+L ++E+ Q+ + + +L + Sbjct: 241 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300 Query: 720 KHFEDLE--FQQLEHESRLDEEKENLTQQL------LREVAEYQRNIVSRKEKISALKKQ 771 K +D + +L +E D + L Q+L + E+ E R++ +E++ +K++ Sbjct: 301 KFHQDQDTIMAKLTNE---DSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEK 357 Query: 772 ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS--------GGKGFPVN 823 + + V+E ++ ++ + E L +E++ L+ K F + Sbjct: 358 ISK-GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLE 416 Query: 824 PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE 883 L + +++ ++ + S S + + + + T+ + L S + ++E Sbjct: 417 VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIE 476 Query: 884 ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 943 R + K L + L + KT + + TM + K L ++S V + Sbjct: 477 SRLE--KTEFTLKEDLTKLKTLTVMFVD-ERKTMSEKL-KKTEDKLQAASSQLQVEQNKV 532 Query: 944 AAMAKD--SESRRMLRGYN--HQQMSEGHRQKSEFYNRTASES----------NVYLNSF 989 + + E++R L+ ++M +++ + N+ +E N+ N Sbjct: 533 TTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRL 592 Query: 990 HYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEK 1049 + KD + L+ DS S +A +N S +E ++ LK A + Sbjct: 593 QSLEAIEKDFLKNKLNQDSG----KSTTALHQENNKIKELSQ--EVERLKLKLKDMKAIE 646 Query: 1050 TRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQ--RQKLIEKE--------VKIR 1099 L+++ E E E +R E+ + + L K L+ + + KL EK K Sbjct: 647 DDLMKT-EDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRL 705 Query: 1100 ERQRAQARPLTRYLPVRKE 1118 + + A++ L+R + KE Sbjct: 706 QEEEAKSGHLSREVDALKE 724 >gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] Length = 1976 Score = 63.5 bits (153), Expect = 1e-09 Identities = 124/604 (20%), Positives = 237/604 (39%), Gaps = 101/604 (16%) Query: 580 EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLD---GEQKSE 636 EE++++ LA + + V++++LEE +K + +++++ R+LD E L E +++ Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1077 Query: 637 TTEL-----MKEKE--------------------ILDHLNRKIAELEKNIVGEKTKEKVK 671 EL KE+E ++ L +IAEL+++ EK Sbjct: 1078 IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137 Query: 672 LDAEREKLERLQELYSEQKTQLDN--CPESMREQLQQQLKRDADLLDVESKHFE-DLEFQ 728 +R+ E L+ L +E + LD + +R + +Q++ L+ E+K+ E ++ Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197 Query: 729 QLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQAN---HIVQQAQREQDH 785 + H + L+E E L Q ++ N+ K+ + K+ ++QQ + E +H Sbjct: 1198 RQRHATALEELSEQLEQ-----AKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEH 1252 Query: 786 --------------FVKEKNNLIMMLQREKENLCNLEKKYSSL-----SGGKGFPVNPNT 826 V E + L + L + L N S+L G F + + Sbjct: 1253 KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAAS 1312 Query: 827 LKEGYISVNE-INEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEER 885 L+ E + E NLS + E L Q + +E E R Sbjct: 1313 LESQLQDTQELLQEETRQKLNLSSRIR--------QLEEEKNSLQEQQEEEE-----EAR 1359 Query: 886 KKQHKEGLYLSDTL--PRKKTTSSISPHFSSATMGRSITPKAHL---PLGQSNSCGSVLP 940 K K+ L L L +KK + S + + A L + L Sbjct: 1360 KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLE 1419 Query: 941 PSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQA 1000 + + ++ + + + Q S +++ +F A E ++ S Y + +D+A Sbjct: 1420 KTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI---SARYAEE--RDRA 1474 Query: 1001 FDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESRE--- 1057 +++ E A S ++ A + EE ER KQ A+ L+ S++ Sbjct: 1475 -------EAEAREKETKALS---LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVG 1524 Query: 1058 ---REMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLP 1114 E+E KRALE++ E + +L+E + Q + ++++ +A R L Sbjct: 1525 KNVHELEKSKRALEQQV---EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581 Query: 1115 VRKE 1118 R E Sbjct: 1582 TRDE 1585 Score = 63.2 bits (152), Expect = 2e-09 Identities = 109/538 (20%), Positives = 214/538 (39%), Gaps = 72/538 (13%) Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640 + ++ A EE R + +EL++ + D+ +++E + +L E+K + Sbjct: 897 QAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEE----EERNQILQNEKKKMQAHI 952 Query: 641 MKEKEILDHLN--RKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPE 698 +E LD R+ +LEK K K K++ E LE + ++K +++ Sbjct: 953 QDLEEQLDEEEGARQKLQLEKVTAEAKIK---KMEEEILLLEDQNSKFIKEKKLMEDRIA 1009 Query: 699 SMREQLQQQLKRDADLLDVESKH---FEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQ 755 QL ++ ++ +L + +K DLE ++L+ E + +E E ++L E + Q Sbjct: 1010 ECSSQLAEEEEKAKNLAKIRNKQEVMISDLE-ERLKKEEKTRQELEKAKRKLDGETTDLQ 1068 Query: 756 RNIVSRKEKISALKKQA---NHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYS 812 I + +I LK Q +Q A D KNN + +++ + + L++ + Sbjct: 1069 DQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFE 1128 Query: 813 SLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ 872 S + N ++ ++E E T+ D A + Q Sbjct: 1129 SEKASR------NKAEKQKRDLSEELEAL--------KTELEDTLDTTAAQQELRTKREQ 1174 Query: 873 PQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTT-SSISPHFSSATMGRSITPKAHLPLGQ 931 + E ++LEE K H+ + D R T +S A ++ K L Sbjct: 1175 -EVAELKKALEEETKNHEA--QIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLET 1231 Query: 932 SNSCGSVLPPSLAAMAKDSESRRMLRGYN----HQQMSEGHRQKSEFYNRTASESNVYLN 987 N + L + +SE +R H ++SEG R + E + + N Sbjct: 1232 DNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN---- 1287 Query: 988 SFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSA--STSNIARIEEMERLLKQA 1045 D++ T + I A + S +++++ + LL++ Sbjct: 1288 --------------------ELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEE 1327 Query: 1046 HAEKTRLLESREREMEAKKRAL----EEEKRRREILEKR---LQEETSQRQKLIEKEV 1096 +K L SR R++E +K +L EEE+ R+ LEK+ LQ + + +K ++ ++ Sbjct: 1328 TRQKLNL-SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDL 1384 Score = 59.3 bits (142), Expect = 2e-08 Identities = 110/581 (18%), Positives = 223/581 (38%), Gaps = 112/581 (19%) Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640 + + +EL ++E + + LEE+++K + + ++ + +L E L ++ Sbjct: 855 QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLA 914 Query: 641 MKE---KEILDHLNRKIAELEKN---IVGEKTK------------------------EKV 670 K+ +EIL L ++ E E+ + EK K EKV Sbjct: 915 AKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKV 974 Query: 671 KLDAEREKLERLQELYSEQKT-----------QLDNCPESMREQLQQQLKRDADLLDVES 719 +A+ +K+E L +Q + ++ C + E+ +++ K A + + + Sbjct: 975 TAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE-EEKAKNLAKIRNKQE 1033 Query: 720 KHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQ---ANHIV 776 DLE ++L+ E + +E E ++L E + Q I + +I LK Q + Sbjct: 1034 VMISDLE-ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEEL 1092 Query: 777 QQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNE 836 Q A D KNN + +++ + + L++ + S + N ++ ++E Sbjct: 1093 QGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR------NKAEKQKRDLSE 1146 Query: 837 INEPCGNSTNLSPSTQFPADADAVAT----EPATAVLASQPQSKEHFRSLEERKKQHKEG 892 E T L + A + T E A A + ++K H +++ +++H Sbjct: 1147 ELEAL--KTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATA 1204 Query: 893 LYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSES 952 L +S A ++ K L N + L + +SE Sbjct: 1205 L------------EELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEH 1252 Query: 953 RRMLRGYN----HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDS 1008 +R H ++SEG R + E + + N Sbjct: 1253 KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN------------------------E 1288 Query: 1009 SDSMETSISACSPDNISSA--STSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRA 1066 D++ T + I A + S +++++ + LL++ +K L SR R++E +K + Sbjct: 1289 LDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLN-LSSRIRQLEEEKNS 1347 Query: 1067 LEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQAR 1107 L+E+ QEE + +K +EK+V + Q A + Sbjct: 1348 LQEQ-----------QEEEEEARKNLEKQVLALQSQLADTK 1377 Score = 53.1 bits (126), Expect = 2e-06 Identities = 145/752 (19%), Positives = 275/752 (36%), Gaps = 141/752 (18%) Query: 367 SLLAGESDRVFATRRNFSCGSVEF--DEADLESLRQASGTPQPALRERKSSISSISGRDD 424 S L E D V ++F D A LES Q + Q L+E ++S R Sbjct: 1283 SKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT---QELLQEETRQKLNLSSRIR 1339 Query: 425 LMDYHRRQREERLREQEMER--LERQRLETILSLCAEYTKPDSRLSTGTTVEDVQK-INK 481 ++ + +E+ E+E R LE+Q L L K D L T ++E+ +K + K Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399 Query: 482 ELEKL-QLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540 + E L Q +E+++ + L R + D D D + AS + + Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH------QRQVASNLEKKQKKF 1453 Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600 D+LL++ E S + + + E R +E A+ R L Sbjct: 1454 DQLLAE-----------------EKSISARYAEERDRAEAEAREKETKALSLARA--LEE 1494 Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660 E K++ + N Q+ DME +LM K D + + + ELEK+ Sbjct: 1495 ALEAKEEFERQNKQL-----RADME-------------DLMSSK---DDVGKNVHELEKS 1533 Query: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720 L++ E +TQL+ + ++ +L+ + ++ ++++ Sbjct: 1534 ------------------KRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQ 1575 Query: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI----------VSRKEKISALKK 770 DL+ + DE+ E + L+++V E + + V+ K+K+ K Sbjct: 1576 FERDLQTR--------DEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLK 1627 Query: 771 QANHIVQQAQREQDHFVKEKNNLIMML---QREKENLCNLEKKYSSLSGGKGFPVNPNTL 827 ++ A + +D +K+ L + QRE E + + S + L Sbjct: 1628 DLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQS-----KESEKKL 1682 Query: 828 KEGYISVNEINEPCGNSTNLSPSTQFPAD--ADAVATEPA--TAVLASQPQSKEHFRSLE 883 K + ++ E +S + D AD + + +A+L + + + LE Sbjct: 1683 KSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLE 1742 Query: 884 ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 943 E ++ + + L + RK T Q ++ + L Sbjct: 1743 EELEEEQSNMELLNDRFRKTTL-------------------------QVDTLNAELAAER 1777 Query: 944 AAMAKDSESRRMLRGYNHQ---QMSEGHRQKSEFYNRTASESNVYLNSFHYP-DHSYKDQ 999 +A K +R+ L N + ++ E + T S + + K++ Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKER 1837 Query: 1000 AFDTLSLDSSDS------METSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLL 1053 A + ++ M+ D AR+++++R L++A E TR Sbjct: 1838 AAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRAN 1897 Query: 1054 ESR---EREMEAKKRALEEEKRRREILEKRLQ 1082 SR +RE++ A E R L+ RL+ Sbjct: 1898 ASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929 Score = 52.8 bits (125), Expect = 2e-06 Identities = 88/446 (19%), Positives = 183/446 (41%), Gaps = 62/446 (13%) Query: 411 ERKSSISSISGRDDLM--DYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS 468 E+ +++ I + ++M D R ++E QE+E+ +R+ L E T +++ Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK-------LDGETTDLQDQIA 1072 Query: 469 TGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528 ++Q EL KLQL+ +E + AL D H+ ++L +++ Sbjct: 1073 ------ELQAQIDEL-KLQLAKKEEELQGALARGDDE-TLHKNNALKVVRELQA-QIAEL 1123 Query: 529 SASFFTPRSTRN----------DEL------LSDLTRTPPPPSSTFPKASSESSYLSIL- 571 F + +++RN +EL L D T K E + L Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183 Query: 572 ---PKTPEGISEEQRSQELAAMEETRIVILN------NLEELKQKIKDINDQMDESFREL 622 K E ++ R + A+EE + NLE+ KQ ++ N ++ + L Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVL 1243 Query: 623 DMECALLDGEQK---SETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKL 679 A + ++K ++ EL + D L ++AE + E L+ +K Sbjct: 1244 QQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKG 1303 Query: 680 ERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEE 739 + + + ++QL + E ++E+ +Q+L + + +E + E Q+ E E+R + E Sbjct: 1304 IKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363 Query: 740 KENLTQQ---------------LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQD 784 K+ L Q + + E ++ ++ E +S ++ + ++ ++ Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN 1423 Query: 785 HFVKEKNNLIMMLQREKENLCNLEKK 810 +E ++L + L +++ NLEKK Sbjct: 1424 RLQQELDDLTVDLDHQRQVASNLEKK 1449 Score = 50.1 bits (118), Expect = 1e-05 Identities = 146/780 (18%), Positives = 316/780 (40%), Gaps = 78/780 (10%) Query: 391 DEADLESLRQASGTP-QPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER-Q 448 D D + +Q T + + E K ++ + + RQR E+ E+LE+ + Sbjct: 1157 DTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216 Query: 449 RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYR 507 R + L + + D++ V+ +Q++ E E + + V E A +S R R Sbjct: 1217 RFKANLEKNKQGLETDNK-ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR 1275 Query: 508 CH--RKDSLPDADLASCGSLSQSS----------ASFFTPRSTRNDELLSDLTRTPPPPS 555 K S +L + +L + + A+ + ELL + TR S Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335 Query: 556 STFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETR---------IVILNNLEELKQ 606 S + E + L + E + Q LA + + + +LEE K+ Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395 Query: 607 KI-KD---INDQMDE---SFRELDMECALLDGEQKSETTELMKEKEILDHLNRK------ 653 K+ KD ++ +++E ++ +L+ L E T +L ++++ +L +K Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455 Query: 654 -IAELEKNIVGEKTKEKVKLDAE-REK------LERLQELYSEQKTQLDNCPESMREQLQ 705 +AE EK+I +E+ + +AE REK L R E E K + + + +R ++ Sbjct: 1456 LLAE-EKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514 Query: 706 QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765 + D+ K+ +LE + E +++E + L ++L E+ + + + + Sbjct: 1515 DLMSSKDDV----GKNVHELEKSKRALEQQVEEMRTQL-EELEDELQATEDAKLRLEVNM 1569 Query: 766 SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS--GGKGFPVN 823 A+K Q +Q + + EK L++ RE E E+K +L+ K ++ Sbjct: 1570 QAMKAQFERDLQTRDEQNE----EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID 1625 Query: 824 PNTLKEGYISVNEI-NEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSL 882 L+ + N+ +E L + A + A +S++ +SL Sbjct: 1626 LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL 1685 Query: 883 EERKKQHKEGLYLSDTLPR--KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLP 940 E Q +E L S+ R ++ ++ +++ G+S L + L Sbjct: 1686 EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL------LDEKRR----LE 1735 Query: 941 PSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQA 1000 +A + ++ E + N + +++ R+ + + +E ++ D++ + Sbjct: 1736 ARIAQLEEELEEEQS----NMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLE 1791 Query: 1001 FDTLSLDSS-DSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESRERE 1059 L + +E ++ + IS A + I ++EE + A +L+ E++ Sbjct: 1792 RQNKELKAKLQELEGAVKSKFKATIS-ALEAKIGQLEEQLEQEAKERAAANKLVRRTEKK 1850 Query: 1060 MEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKED 1119 ++ +E+E+R + ++++ E+ + R K ++++++ E + +A R L +D Sbjct: 1851 LKEIFMQVEDERRHADQYKEQM-EKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909 Score = 30.8 bits (68), Expect = 8.5 Identities = 22/83 (26%), Positives = 43/83 (51%), Gaps = 11/83 (13%) Query: 1056 REREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQR------AQARPL 1109 +E E++AK L + K ++ +E L+E + Q+L+E++ + E+ + A+A + Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909 Query: 1110 TRYLPVRKEDF-----DLRSHVE 1127 L +K++ DL S VE Sbjct: 910 RARLAAKKQELEEILHDLESRVE 932 >gi|38044112 restin isoform b [Homo sapiens] Length = 1392 Score = 62.0 bits (149), Expect = 3e-09 Identities = 128/605 (21%), Positives = 259/605 (42%), Gaps = 94/605 (15%) Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQM-DESFRELDMECALLDGEQKSETTE 639 +Q + A + ++ +LN LEE K+K++D+ ++ +ES + D+E A + +KS E Sbjct: 411 DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATV--SEKSRIME 468 Query: 640 LMKE-----KEILD------------------HLNRKIAELEKNIVGEKTKEKVKLDAER 676 L K+ +E+ + L ++I+ L++ + +T + ++ + + Sbjct: 469 LEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK 528 Query: 677 EKLERLQELYSEQ-------KTQLDNCPESMREQLQQQLKRDADLLDV-ESKHFEDLEFQ 728 E +E + ++ +L ES++ +L+ K ++D++ + +SK LE Sbjct: 529 EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSK----LETA 584 Query: 729 QLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDH--- 785 H+ ++E K + ++ L E AE+ K +I ++ H ++ Q +QD Sbjct: 585 IASHQQAMEELKVSFSKGLGTETAEF----AELKTQIEKMRLDYQHEIENLQNQQDSERA 640 Query: 786 -FVKEKNNL---IMMLQREKENLCNLEKKYSSLSGGKG-----FPVNPNTLKEGYISVNE 836 KE L +M + +EKEN +LE S L + N L+E I V E Sbjct: 641 AHAKEMEALRAKLMKVIKEKEN--SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE 698 Query: 837 ---INEPCGNSTNL--SPSTQFPADADAVATEPATAVLASQPQS--KEHFRSLEERKKQH 889 + C T + + ++Q A + + A +S+ +S K+ + LE +KQ Sbjct: 699 LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQI 758 Query: 890 KEGLYLSDTLPRKKTTSSISPHFSSATMGRSI-TPKAHLPLGQSNSCGSVLPPSLAAM-- 946 K K SS + + GR + L + + L L + Sbjct: 759 KH------LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE 812 Query: 947 --AKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSY--KDQAFD 1002 A+ SE ++ + +++ H QK E +N +S+ + + + KD+ + Sbjct: 813 KFAEASEEAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREE 871 Query: 1003 TLSLDSSDSMETSIS---ACSPDNISSASTSN------IARIEEMERLLKQAHAEKTRLL 1053 L + + + +E I+ S DN S + N +EE++ L +A+ + L Sbjct: 872 QL-IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQ 930 Query: 1054 ESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIE------KEVKIRERQRAQAR 1107 +S E +++ +E ++ E +K L+ + S +K +E +E+K R +RA + Sbjct: 931 KSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR-YERATSE 989 Query: 1108 PLTRY 1112 T++ Sbjct: 990 TKTKH 994 Score = 55.8 bits (133), Expect = 2e-07 Identities = 124/583 (21%), Positives = 222/583 (38%), Gaps = 87/583 (14%) Query: 261 RATENQLTPL-SLPPRNSLGNSKRTKL------GEKDLPHSVIDNDNYLNFSSLSSGALP 313 +ATE +L L +L +S G S+ KL EK + H I+ N S + ++ Sbjct: 721 KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK----NAESSKASSI- 775 Query: 314 YKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGES 373 T +G + L S K L + F +AS + S+ Sbjct: 776 --TRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE-TV 832 Query: 374 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERK-----------------SSI 416 +++ F+ S +DLE LR+ + RE+ + I Sbjct: 833 NKLHQKEEQFNMLS-----SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEI 887 Query: 417 SSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDV 476 +SG D+ + E RL+E+++E L+ + TK + E+ Sbjct: 888 MKMSG-DNSSQLTKMNDELRLKERDVEELQ-----------LKLTKAN---------ENA 926 Query: 477 QKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASF 532 + K +E + + E+S E A + + RK S + + + C L Sbjct: 927 SFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERA 986 Query: 533 FTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEE 592 + T+++E+L +L +T A E+S +L + E + +++ E+ Sbjct: 987 TSETKTKHEEILQNLQKTLLDTEDKLKGAREENS--GLLQELEELRKQADKAKAAQTAED 1044 Query: 593 TRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNR 652 ++ +E + + + D + + L E L EL K KE+L N+ Sbjct: 1045 AMQIMEQMTKEKTETLASLEDTKQTNAK-LQNELDTLKENNLKNVEELNKSKELLTVENQ 1103 Query: 653 KIAELEKNI------VGEKTKEKVKLDAEREKL-ERL----QELYSEQKTQLDNCPESMR 701 K+ E K I +K+++ L E KL E L E+ S QK L+ + Sbjct: 1104 KMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQK--LEEERSVLN 1161 Query: 702 EQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSR 761 QL + KR++ + + L+ + + S L EK+ ++L EV V R Sbjct: 1162 NQLLEMKKRESKFIKDADEEKASLQ-KSISITSALLTEKDAELEKLRNEVT------VLR 1214 Query: 762 KEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENL 804 E SA K + +VQ + ++ + NL + L+ K L Sbjct: 1215 GENASA--KSLHSVVQTLESDKVKLELKVKNLELQLKENKRQL 1255 Score = 53.9 bits (128), Expect = 9e-07 Identities = 90/455 (19%), Positives = 188/455 (41%), Gaps = 80/455 (17%) Query: 409 LRERKSSISSISGR-DDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRL 467 ++E+++S+ +I + D D H + E+ L + + ++ + LE + + C E TK Sbjct: 657 IKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK----- 711 Query: 468 STGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASC----- 522 I+ +L+ ++E+ + +AL + + K + A Sbjct: 712 ----------VIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL 761 Query: 523 ---GSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYL--SILPKTPEG 577 + S AS T + L++L S E L + E Sbjct: 762 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEA 821 Query: 578 ISEEQRSQE----LAAMEETRIVILNNLEELKQKIKDINDQMDESFRELD---------- 623 +S ++ QE L EE ++ ++LE+L++ + D M+ FRE D Sbjct: 822 VSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD----MEAKFREKDEREEQLIKAK 877 Query: 624 -------MECALLDGEQKSETTEL-----MKEKEILDHLNRKIAELEKNI-VGEKTKEKV 670 E + G+ S+ T++ +KE+++ + L K+ + +N +K+ E + Sbjct: 878 EKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV-EELQLKLTKANENASFLQKSIEDM 936 Query: 671 KLDAEREKLERLQELYSEQKTQLDNCPESMREQLQ------QQLKR--DADLLDVESKHF 722 + AE+ + E ++ + E+K +L+ + ++++ Q+LK + + ++KH Sbjct: 937 TVKAEQSQQEAAKK-HEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHE 995 Query: 723 EDLEFQQ---LEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQA 779 E L+ Q L+ E +L +E LL+E+ E ++ A K +A + A Sbjct: 996 EILQNLQKTLLDTEDKLKGAREE-NSGLLQELEELRK---------QADKAKAAQTAEDA 1045 Query: 780 QREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 814 + + KEK + L+ K+ L+ + +L Sbjct: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1080 Score = 53.5 bits (127), Expect = 1e-06 Identities = 116/587 (19%), Positives = 225/587 (38%), Gaps = 85/587 (14%) Query: 577 GISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDE--SFRELDMECALLDGEQK 634 G EE +E+ A+ + E LK K++ N + + + + +E A+ +Q Sbjct: 532 GAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQA 591 Query: 635 SETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLD 694 E ++ K L + AEL+ I EK++LD + E +E LQ ++ Sbjct: 592 MEELKVSFSKG-LGTETAEFAELKTQI------EKMRLDYQHE-IENLQNQQDSERAAHA 643 Query: 695 NCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL-EHESRLDEEKE------------ 741 E++R +L + +K + L+ + E Q L E E L++ +E Sbjct: 644 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 703 Query: 742 -----------NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ---AQREQDHFV 787 N T QL + E ++ + ++ S K + + QQ A+++ H Sbjct: 704 AKCNEQTKVIDNFTSQL-KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE 762 Query: 788 KEKN-------NLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840 EKN ++ LQ + L NL++ S +S V KE I + E Sbjct: 763 IEKNAESSKASSITRELQGRELKLTNLQENLSEVS-----QVKETLEKELQILKEKFAEA 817 Query: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEH-------FRSLEERKKQ---HK 890 + ++ S Q + E + + + +E+ FR +ER++Q K Sbjct: 818 SEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAK 877 Query: 891 EGLY--LSDTLPRKKTTSS-ISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMA 947 E L +++ + SS ++ + + L L ++N S L S+ M Sbjct: 878 EKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMT 937 Query: 948 KDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLD 1007 +E + Q+ ++ H ++ + R S+ + + H K + ++ + + Sbjct: 938 VKAEQ-------SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR-YERATSE 989 Query: 1008 SSDSMETSISAC------SPDNISSASTSNIARIEEMERLLKQAHAEKT--------RLL 1053 + E + + D + A N ++E+E L KQA K +++ Sbjct: 990 TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIM 1049 Query: 1054 ESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRE 1100 E +E +LE+ K+ L+ L K +E+ K +E Sbjct: 1050 EQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKE 1096 Score = 35.4 bits (80), Expect = 0.34 Identities = 61/280 (21%), Positives = 118/280 (42%), Gaps = 29/280 (10%) Query: 534 TPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTP---EGISEEQR--SQELA 588 +P ++ + S + PS T + S Y + T E + E+Q+ Q LA Sbjct: 310 SPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLA 369 Query: 589 AMEETRIVIL---NNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645 + R + +++ E++Q++ D D+ EL+ + L ++ E ++ Sbjct: 370 ERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLN 429 Query: 646 ILDHLNRKIAELEKNIVGEK-TKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQL 704 L+ RK+ +L+ + E TK +++ EK R+ EL + ++ E L Sbjct: 430 QLEEEKRKVEDLQFRVEEESITKGDLEVATVSEK-SRIMELEKDLALRVQEVAE-----L 483 Query: 705 QQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEK 764 +++L+ + DV D+ L+ S L +EK +T+ ++QR I S KE Sbjct: 484 RRRLESNKPAGDV------DMSLSLLQEISSL-QEKLEVTR------TDHQREITSLKEH 530 Query: 765 ISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQR-EKEN 803 A ++ ++ + KE +L L+ KEN Sbjct: 531 FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKEN 570 Score = 34.3 bits (77), Expect = 0.77 Identities = 27/104 (25%), Positives = 52/104 (50%), Gaps = 24/104 (23%) Query: 1028 STSNIARIEEMERLLKQAHAEKTRLLESR-----------EREMEAKKRALEEEKRRREI 1076 +TS++ IE+ L + H + LE++ +RE LEEEKR+ E Sbjct: 381 ATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVED 440 Query: 1077 LEKRLQEET-----------SQRQKL--IEKEVKIRERQRAQAR 1107 L+ R++EE+ S++ ++ +EK++ +R ++ A+ R Sbjct: 441 LQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELR 484 >gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo sapiens] Length = 1870 Score = 62.0 bits (149), Expect = 3e-09 Identities = 151/727 (20%), Positives = 292/727 (40%), Gaps = 92/727 (12%) Query: 137 ERALRLSE-KPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISR 195 E+A+R+ + + S+Y R HD + +E K +L + + L D +R Sbjct: 317 EKAVRVDKLESEVSRYKER--LHDIEFYKARVEELKEDNQVL-LETKTMLEDQLEGTRAR 373 Query: 196 SGAASMPSSPKQARKMSIQDSLALQPKLTRHK--ELASENINLR-TRKYSSSSLSHMGAY 252 S K + D + ++ + R K EL EN+ L +K S H+G Sbjct: 374 SDKLHELEKENLQLKAKLHD-MEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGW- 431 Query: 253 SRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGAL 312 L ++ R +E LS P+ SLG+ + L + + L + Sbjct: 432 --ELEQISRTSE-----LSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484 Query: 313 PYKTSASE------GNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV------ 360 + +AS+ N +S + + + V K L + + + D + + + Sbjct: 485 SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544 Query: 361 ---GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS 417 + +L E++ + T + S EA ++ + + + +++E S +S Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604 Query: 418 SISG-----RDDLMDYHRRQREERLREQEMERLER-----QRLETILSLCAEYTKPDSRL 467 I + +L Y + E E+ LE+ Q+ T L + E + + Sbjct: 605 KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664 Query: 468 STGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYRCHRKDSLPDADLASCGSLS 526 ++ ++++ N++L+K S + F+ E+L +++ + + + C S+ Sbjct: 665 NS-----ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK 719 Query: 527 QSSASFFTPRSTRNDELLSD---LTRTPPPPSSTFPKASS-ESSYLSI------LPKTPE 576 + N EL S+ L + ++F K E SY + L KT E Sbjct: 720 MAQLQL------ENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE 773 Query: 577 GISE--EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQK 634 ++ +Q EL +E + NLEELK K + +Q+++ + L+ E + L+ ++K Sbjct: 774 NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL-EQLEKENKSLEQETSQLEKDKK 832 Query: 635 S---ETTELMKEKEI----LDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYS 687 E L ++ EI L+ N KI LEK KT K ++ +E RL+EL Sbjct: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE---NKTLSK-EIGIYKESCVRLKELEK 888 Query: 688 EQKTQLDNCP------ESMREQL------QQQLKRDADLLDVESKHFEDLEFQQLEHESR 735 E K + ++RE L QQ+ D + L E + L ++L H+ + Sbjct: 889 ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI-GLNKERLLHDEQ 947 Query: 736 LDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIM 795 +++ L + L + +++ ++EKI+AL+ + Q+ + K N Sbjct: 948 STDDRYKLLESKLESTLK--KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1005 Query: 796 MLQREKE 802 + QR+ E Sbjct: 1006 LKQRQDE 1012 Score = 53.5 bits (127), Expect = 1e-06 Identities = 92/453 (20%), Positives = 176/453 (38%), Gaps = 54/453 (11%) Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREER--LREQEMERLERQR 449 +A + LRQ L + K + + ++ R Q+E L + R+ R Sbjct: 257 KAKIRRLRQELEEKTEQLLDCKQELEQME-----IELKRLQQENMNLLSDARSARMYRDE 311 Query: 450 LETILSLCAEYTKPDSRLST-GTTVEDVQKINKELEKLQLSDEESVFEEALMSPD----T 504 L+ + K +S +S + D++ +E+L+ D + + E M D T Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK-EDNQVLLETKTMLEDQLEGT 370 Query: 505 RYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKAS-- 562 R R + L +L L R + + ++T S Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430 Query: 563 ------SESSYLSILPKTPEGIS-EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQM 615 S +S LS P+ G E S L +E + +EEL+ + + Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA 490 Query: 616 DESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAE 675 + + ++ E L + + E+++EK+ L + L K+++ EK + + ++ Sbjct: 491 SKILK-MEKENQRLSKKVEILENEIVQEKQSLQNCQN----LSKDLMKEKAQLEKTIETL 545 Query: 676 REKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVE-------------SKHF 722 RE ER ++ ++ L+ S+R+ + Q+ +A + D+E S Sbjct: 546 RENSERQIKILEQENEHLNQTVSSLRQ--RSQISAEARVKDIEKENKILHESIKETSSKL 603 Query: 723 EDLEFQ------QLEH---ESRLDEEKENLTQQLLREVAEYQRNIVSRK---EKISALKK 770 +EF+ +LEH + EE EN L +E Q+ I + K EKI AL++ Sbjct: 604 SKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663 Query: 771 QANHIVQQAQREQDHFVKEKNNLIMMLQREKEN 803 + + + ++ ++ + KN + EKEN Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKEN 696 Score = 47.8 bits (112), Expect = 7e-05 Identities = 116/567 (20%), Positives = 226/567 (39%), Gaps = 56/567 (9%) Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQM-DESFRELDMECALLDGEQKSETTELMKEK 644 EL A+ E + +++L+ ++ +++ D F + +E D + ET +++++ Sbjct: 311 ELDALREKAV----RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 366 Query: 645 -EILDHLNRKIAELEKNIVGEKTK---EKVKLDAEREKLERLQELYSEQKTQLDNCPESM 700 E + K+ ELEK + K K +++ D +R+K+E L E E T +SM Sbjct: 367 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME---ENMTLEMAQKQSM 423 Query: 701 REQLQ-----QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQ 755 E L +Q+ R ++L + K E +L L E EN Q L + V E + Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGH-EVNELTSSRLLKLEMEN--QSLTKTVEELR 480 Query: 756 RNIVS---RKEKISALKKQANHIVQQAQREQDHFVKEKN------NLIMMLQREKENLCN 806 + S KI ++K+ + ++ + ++ V+EK NL L +EK Sbjct: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK---AQ 537 Query: 807 LEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPAT 866 LEK +L N+ ++ I E ++L +Q A+A E Sbjct: 538 LEKTIETL--------RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589 Query: 867 AVL-ASQPQSKEHFRSLEERKKQHKEGL-YLSDTLPRKKTTSSISPHFSSAT--MGRSIT 922 +L S ++ +E K+Q K+ L + + R + + H + + IT Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKIT 649 Query: 923 PKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASES 982 +C + + E+R++ + + + + E N E Sbjct: 650 -------NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE 702 Query: 983 NVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLL 1042 N+ L + L L++ + + AS R+E + L Sbjct: 703 NLELRR-NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL 761 Query: 1043 KQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQE--ETSQRQKLIEKEVKIRE 1100 + + LE+ ++++ + L++ + + L+K L+E +S+R + +EKE K E Sbjct: 762 DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLE 821 Query: 1101 RQRAQARPLTRYLPVRKEDFDLRSHVE 1127 ++ +Q + L KE+ LR E Sbjct: 822 QETSQLEKDKKQL--EKENKRLRQQAE 846 Score = 47.0 bits (110), Expect = 1e-04 Identities = 86/418 (20%), Positives = 180/418 (43%), Gaps = 80/418 (19%) Query: 432 QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINK---------- 481 +R+ ++ EQE E L +T+ SL + S++S V+D++K NK Sbjct: 550 ERQIKILEQENEHLN----QTVSSL-----RQRSQISAEARVKDIEKENKILHESIKETS 600 Query: 482 ------ELEKLQLSDEESVFEE----ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSAS 531 E EK Q+ E ++E A + + +++ L + + + + Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660 Query: 532 FFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQ-------RS 584 ++ S+L R T + + L L K + EE S Sbjct: 661 L--------EQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712 Query: 585 QELAAMEETRIVILNN-LEELKQKIKD----------INDQMDESFRELDMECALLDGEQ 633 + A+M+ ++ + N LE K+++K ++++ S++ LD+E L Sbjct: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772 Query: 634 KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAER-EKLERLQELYSEQKTQ 692 ++ ++ + + L L + L+KN+ E++K+ ++R E+LE+ + ++ +Q Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNL------EELKISSKRLEQLEKENKSLEQETSQ 826 Query: 693 LDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDE-EKENLTQQLLREV 751 L E ++QL+++ KR +++ E E+ ++ EKEN T L +E+ Sbjct: 827 L----EKDKKQLEKENKRLRQQAEIKDTTLE-------ENNVKIGNLEKENKT--LSKEI 873 Query: 752 AEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEK 809 Y+ + V KE L+K+ +V++A + V + +L+ + ++ +LEK Sbjct: 874 GIYKESCVRLKE----LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927 Score = 45.8 bits (107), Expect = 3e-04 Identities = 95/470 (20%), Positives = 192/470 (40%), Gaps = 46/470 (9%) Query: 372 ESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRR 431 E+ R+ T N S ++ E++L+ L + T Q L E K S + + Sbjct: 764 ENQRLQKTLEN-SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE---------QL 813 Query: 432 QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKI-NKELEKLQLSD 490 ++E + EQE +LE+ + + L + + + + T E+ KI N E E LS Sbjct: 814 EKENKSLEQETSQLEKDKKQ--LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871 Query: 491 EESVFEEALMSPDTRYRCHRKDSLPDA--DLASCGSLSQSSASFFTPRSTRNDEL---LS 545 E +++E+ + + K+ + A D+ + +L + S N++L Sbjct: 872 EIGIYKESCVRLKELEK-ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930 Query: 546 DLTRTPPPPSSTFPKASSESSYLSILPKTPEGI---SEEQRSQELAAMEETRIVILNNLE 602 +L + S +L E S E + +++AA+E N + Sbjct: 931 ELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 990 Query: 603 ELKQKIKDIN------------DQMDESFRELDMECALLDGEQKSETTELMKEKEILDHL 650 +L+Q++K + ++M +S + E + E + T EL+K K+ L + Sbjct: 991 QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1050 Query: 651 NRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKR 710 R A L+ KT+ K +L+ + L+ Q L +++ Q +L+ Sbjct: 1051 ERNNATLQAEKQALKTQLK-QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ-NAKLQV 1108 Query: 711 DADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISAL-K 769 + L+ +S + Q L +S L+ E E++ ++ ++ +++ EK+ L + Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE-REDLKSLYDSLIKDHEKLELLHE 1167 Query: 770 KQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKG 819 +QA+ E + + + L + + +LE +Y+ L KG Sbjct: 1168 RQAS--------EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKG 1209 Score = 40.0 bits (92), Expect = 0.014 Identities = 44/193 (22%), Positives = 94/193 (48%), Gaps = 17/193 (8%) Query: 585 QELAAMEETRIVILN-NLEELKQKIKDI---NDQMDESFRELDMECALLDGEQKSETTEL 640 +++ +E+ ++++ N N E + + K + ND+++ ++ +L E +L + K+ Sbjct: 1215 EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNL---- 1270 Query: 641 MKEKEILDHLNRKIAELEKNIVGEKTKEKVK-LDAEREKLERLQELYSEQKTQLDNCPES 699 K +L+ N K+ + K KE+ + LD KL EL S+ K L+ Sbjct: 1271 ---KSLLN--NSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1325 Query: 700 MREQLQQQLKRDADLLD--VESKHFEDLEFQQ-LEHESRLDEEKENLTQQLLREVAEYQR 756 + +Q+Q + ++ LL+ +ESK +E +Q ++ + L +KE L ++++ + Y Sbjct: 1326 LLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDP 1385 Query: 757 NIVSRKEKISALK 769 + R+ LK Sbjct: 1386 SPPRRRGNWITLK 1398 Score = 31.2 bits (69), Expect = 6.5 Identities = 43/224 (19%), Positives = 103/224 (45%), Gaps = 30/224 (13%) Query: 605 KQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGE 664 ++ +K + D + + +L+ LL Q SE L+ + L ++ + E+E + + Sbjct: 1145 REDLKSLYDSLIKDHEKLE----LLHERQASEYESLISKHGTLKSAHKNL-EVEHRDLED 1199 Query: 665 KTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFED 724 + + +K + E LE++ ++ E+ + E++ + ++ + L S+ ++ Sbjct: 1200 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1259 Query: 725 LEFQQLEHE--------SRLDEEKENLTQQLLREVAEYQR-NIVSRK-----EKISALK- 769 E Q +H+ S+L++ + L+E +YQ+ +I S K E +S LK Sbjct: 1260 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE--QYQQLDITSTKLNNQCELLSQLKG 1317 Query: 770 ---KQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810 ++ H++ Q Q + +N ++ E ++L ++E++ Sbjct: 1318 NLEEENRHLLDQIQT-----LMLQNRTLLEQNMESKDLFHVEQR 1356 >gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] Length = 1960 Score = 61.6 bits (148), Expect = 4e-09 Identities = 102/459 (22%), Positives = 194/459 (42%), Gaps = 88/459 (19%) Query: 411 ERKSSISSISGRDDLM--DYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS 468 E+ S++ + + + M D R R E + QE+E+ R++LE Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKT-RRKLE------------GDSTD 1059 Query: 469 TGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528 + ++Q EL K+QL+ +E + AL + +L S +S+ Sbjct: 1060 LSDQIAELQAQIAEL-KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES--QISEL 1116 Query: 529 SASFFTPRSTRN-------------DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTP 575 + R++RN + L ++L T ++ S ++IL KT Sbjct: 1117 QEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTL 1176 Query: 576 EGISEEQRSQELAAMEETRIVILNNLEELKQKI---KDINDQMDESFRELDMECALLDGE 632 E EE ++ E A ++E R +EEL +++ K + ++++ + L+ E GE Sbjct: 1177 E---EEAKTHE-AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE----RGE 1228 Query: 633 QKSETTELMKEKEILDHLNRKI-AELEKNIV----GEK---------TKEKVKLD----- 673 +E L++ K +H +K+ A+L++ V GE+ TK +V+LD Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL 1288 Query: 674 --AEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLE 731 K +L + +S ++QL + E ++E+ +Q+L L VE + E QLE Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE--QLE 1346 Query: 732 HESRLDEEKENLTQQL--------------------LREVAEYQRNIVSRKEKISALKKQ 771 E +E K NL +Q+ L E +R + E +S ++ Sbjct: 1347 EE---EEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEE 1403 Query: 772 ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810 + ++ + +E ++L++ L ++++ CNLEKK Sbjct: 1404 KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK 1442 Score = 58.5 bits (140), Expect = 4e-08 Identities = 102/477 (21%), Positives = 195/477 (40%), Gaps = 47/477 (9%) Query: 394 DLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMER--LERQRLE 451 D +L Q L+E S+S + ++ + E+L E+E + LE+Q + Sbjct: 1302 DFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQ-IA 1360 Query: 452 TILSLCAEYTKP--DSRLSTGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYRC 508 T+ + A+ K DS T E +K+ K+LE L EE V + L TR + Sbjct: 1361 TLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ 1420 Query: 509 HRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYL 568 D L D D + SA + + D+LL++ + +A +E+ Sbjct: 1421 ELDDLLVDLDH------QRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474 Query: 569 SILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECAL 628 + EE Q+ A +E +E+L D + +S EL+ Sbjct: 1475 ETKALSLARALEEAMEQK-AELERLNKQFRTEMEDLMSS----KDDVGKSVHELEKSKRA 1529 Query: 629 LDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSE 688 L+ + + T+L + ++ L LE N+ K + + L E+ E ++ Sbjct: 1530 LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVR 1589 Query: 689 QKTQLDNCPESMREQ----LQQQLKRDADLLDVES-------------KHFEDLEFQQLE 731 Q +++ E R+Q + + K + DL D+E+ K L+ Q + Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649 Query: 732 HESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQ---ANHIVQQAQREQDHFVK 788 LD+ + + +++L + E ++ + S + ++ L+++ A +QAQ+E+D Sbjct: 1650 CMRELDDTRAS-REEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELAD 1708 Query: 789 E------KNNLIMMLQREKE-NLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEIN 838 E K L + +R E + LE++ G +N + LK+ + +++IN Sbjct: 1709 EIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTEL-IN-DRLKKANLQIDQIN 1763 Score = 56.6 bits (135), Expect = 1e-07 Identities = 122/643 (18%), Positives = 252/643 (39%), Gaps = 107/643 (16%) Query: 580 EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTE 639 EE++S+ LA ++ ++ +LEE ++ + +++++ R+L+ + L + + Sbjct: 1011 EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ 1070 Query: 640 LMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPES 699 + + K L ++ + E ++ + L RE ++ EL ++ + + + Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL--QEDLESERASRN 1128 Query: 700 MREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIV 759 E+ ++ L + + L E + D Q E S+ ++E L + L E ++ I Sbjct: 1129 KAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188 Query: 760 SRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKG 819 ++K S ++ ++Q +R + + K K L+ E+ L N + L GKG Sbjct: 1189 EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT----LENERGELAN---EVKVLLQGKG 1241 Query: 820 FPVNPNTLKEGYISVNEI--NEPCGNSTNLSPS-TQFPADADAVATEPATAVLASQPQSK 876 + E + ++ NE T L+ T+ + D V L SQ SK Sbjct: 1242 DSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTG------LLSQSDSK 1295 Query: 877 -----EHFRSLEER--------KKQHKEGLYLSDTLPR-KKTTSSISPHFSSATMGRSIT 922 + F +LE + ++++++ L LS L + + +S + Sbjct: 1296 SSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355 Query: 923 PKAHLPL-GQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN----- 976 K L Q + S+ + E +R L+ + + +S+ H +K Y+ Sbjct: 1356 EKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ-KDLEGLSQRHEEKVAAYDKLEKT 1414 Query: 977 --RTASESNVYLNSFHYPDHS-----YKDQAFDTLSLD---------------SSDSMET 1014 R E + L + S K + FD L + +++ E Sbjct: 1415 KTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474 Query: 1015 SISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESRE------REMEAKKRALE 1068 A S ++ A + + E+ERL KQ E L+ S++ E+E KRALE Sbjct: 1475 ETKALS---LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531 Query: 1069 EE----KRRREILEKRLQ----------------------------EETSQRQKLI---- 1092 ++ K + E LE LQ E++ +++K + Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQV 1591 Query: 1093 -EKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNID 1134 E E ++ + ++ ++ + + + DL +H+++A N D Sbjct: 1592 REMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD 1634 Score = 49.3 bits (116), Expect = 2e-05 Identities = 94/454 (20%), Positives = 191/454 (42%), Gaps = 42/454 (9%) Query: 388 VEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMER--L 445 VE +E + L+ Q ++E + + + + E +L++ E E+ L Sbjct: 924 VEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIIL 983 Query: 446 ERQRLETILSLCAEYTKPDSRLSTGTT-VEDVQKINKELEKLQLSDEESV--FEEALMSP 502 E Q + L E + R++ TT + + ++ +K L KL+ E + EE L Sbjct: 984 EDQNCK----LAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039 Query: 503 DTRY----RCHRKDSLPDADLAS-CGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSST 557 + + + RK DL+ L A + + +EL + L R + Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQK 1099 Query: 558 FPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDIND---- 613 S + + E + E+ S+ A E+ + + LE LK +++D D Sbjct: 1100 NMALKKIRELESQISELQEDLESERASRNKA--EKQKRDLGEELEALKTELEDTLDSTAA 1157 Query: 614 -QMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKE-KVK 671 Q S RE ++ E++++T E ++ H ++ + EL + + E+TK K Sbjct: 1158 QQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH-SQAVEELAEQL--EQTKRVKAN 1214 Query: 672 LDAEREKLERLQ-ELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL 730 L+ ++ LE + EL +E K L +S E +++++ L V+ E + + Sbjct: 1215 LEKAKQTLENERGELANEVKVLLQGKGDS--EHKRKKVEAQLQELQVKFNEGERVRTELA 1272 Query: 731 EHESRLDEEKENLT----------QQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780 + ++L E +N+T +L ++ + + + +E + +Q + + + Sbjct: 1273 DKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK 1332 Query: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 814 + +D EKN+ L+ E+E NLEK+ ++L Sbjct: 1333 QVED----EKNSFREQLEEEEEAKHNLEKQIATL 1362 Score = 47.0 bits (110), Expect = 1e-04 Identities = 87/403 (21%), Positives = 163/403 (40%), Gaps = 50/403 (12%) Query: 392 EADLESLRQASGTPQPALRERKSSIS-SISGRDDLMDYHRRQREERLREQEMERLERQRL 450 E +L++ A + L+ K+ + GRD+ + ++Q ++RE E E LE +R Sbjct: 1545 EDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAE-LEDERK 1603 Query: 451 ETILSLCA----EYTKPDSRLSTGTTVEDVQKINKELEKLQ---------LSDEESVFEE 497 + +++ A E D + ++ + K+L KLQ L D + EE Sbjct: 1604 QRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREE 1663 Query: 498 ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSST 557 L +K +A++ ++ DEL ++ + S Sbjct: 1664 ILAQAKEN---EKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANS----SGK 1716 Query: 558 FPKASSESSYLSI-LPKTPEGISEEQRSQEL-------AAMEETRIVILNNLEELK-QKI 608 A E L + + E + EEQ + EL A ++ +I NLE QK Sbjct: 1717 GALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKN 1776 Query: 609 KDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKE 668 ++ Q++ +EL ++ ++G KS K K + L KIA+LE+ + E TKE Sbjct: 1777 ENARQQLERQNKELKVKLQEMEGTVKS------KYKASITALEAKIAQLEEQLDNE-TKE 1829 Query: 669 KVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQ 728 + A +++ R ++ + Q+D+ + +Q K AD K + + Sbjct: 1830 R---QAACKQVRRTEKKLKDVLLQVDD-----ERRNAEQYKDQADKASTRLKQLK----R 1877 Query: 729 QLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQ 771 QLE + ++L RE+ + + ++S+LK + Sbjct: 1878 QLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920 Score = 46.2 bits (108), Expect = 2e-04 Identities = 108/554 (19%), Positives = 220/554 (39%), Gaps = 71/554 (12%) Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELM 641 Q EL A E + L KQ++++I ++ E + C L E+K + Sbjct: 890 QAETELCAEAEE---LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946 Query: 642 KEKEILDHLN--RKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPES 699 + +E L+ R+ +LEK K K KL+ E+ LE +++K L++ Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLK---KLEEEQIILEDQNCKLAKEKKLLEDRIAE 1003 Query: 700 MREQLQQQLKRDADLLDVESKH---FEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQR 756 L ++ ++ L +++KH DLE ++L E + +E E ++L + + Sbjct: 1004 FTTNLTEEEEKSKSLAKLKNKHEAMITDLE-ERLRREEKQRQELEKTRRKLEGDSTDLSD 1062 Query: 757 NIVSRKEKISALKKQ---ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSS 813 I + +I+ LK Q +Q A + +KN + ++ + + L++ S Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLES 1122 Query: 814 LSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAV----L 869 + N ++ + E E T L + A + ++ V Sbjct: 1123 ERASR------NKAEKQKRDLGEELEAL--KTELEDTLDSTAAQQELRSKREQEVNILKK 1174 Query: 870 ASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPL 929 + ++K H ++E +++H + + + + + T + + A K L Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQA--VEELAEQLEQTKRVKANLEKA--------KQTLEN 1224 Query: 930 GQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQM----SEGHRQKSEFYNRTASESNVY 985 + V L DSE +R Q++ +EG R ++E ++ ++ V Sbjct: 1225 ERGELANEV--KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADK-VTKLQVE 1281 Query: 986 LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1045 L++ T L SDS + ++ + S+ +++++ + LL++ Sbjct: 1282 LDNV-------------TGLLSQSDSKSSKLT----KDFSALE----SQLQDTQELLQEE 1320 Query: 1046 HAEKTRL---LESREREMEAKKRALEEEKRRREILEKR---LQEETSQRQKLIEKEVKIR 1099 + +K L L+ E E + + LEEE+ + LEK+ L + + +K +E V Sbjct: 1321 NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCL 1380 Query: 1100 ERQRAQARPLTRYL 1113 E R L + L Sbjct: 1381 ETAEEVKRKLQKDL 1394 Score = 32.3 bits (72), Expect = 2.9 Identities = 25/109 (22%), Positives = 53/109 (48%), Gaps = 9/109 (8%) Query: 1037 EMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEV 1096 ++ R ++ A++ L++ RE+++ A+ R E E L+ +L E Q Q+ ++ E Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTE-----METLQSQLMAEKLQLQEQLQAET 893 Query: 1097 KI-RERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEK 1144 ++ E + +AR + + + DL + VE + C H+ +K Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVE---EEEERCQHLQAEKK 939 >gi|114155142 nuclear pore complex-associated protein TPR [Homo sapiens] Length = 2363 Score = 61.6 bits (148), Expect = 4e-09 Identities = 135/713 (18%), Positives = 274/713 (38%), Gaps = 93/713 (13%) Query: 406 QPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEY----T 461 Q + R K S+ DDL+ RQ EE++ + ++RL+T S +Y T Sbjct: 918 QSSQRTGKGQPSNKEDVDDLVS-QLRQTEEQVNDL------KERLKTSTSNVEQYQAMVT 970 Query: 462 KPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS 521 + L+ V + + N E+ + ++ ++ E+ LM + K L D + Sbjct: 971 SLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKE-----KQELQDDKRRA 1025 Query: 522 CGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEE 581 S+ Q + S+ +E+ L R S+ + + + + + Sbjct: 1026 IESMEQQLSELKKTLSSVQNEVQEALQRASTALSN------EQQARRDCQEQAKIAVEAQ 1079 Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELM 641 + + + + L +E K+ + ++E+ ++ + + LL+ + E E M Sbjct: 1080 NKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ--LLECKASWEERERM 1137 Query: 642 KEKEI------LDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDN 695 + E+ + L ++ L I EK +KV + L SE+ + Sbjct: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQI--EKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQ 1195 Query: 696 CPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQ 755 E +R ++R+ ++ + FE + + L + R++ L RE+ E Q Sbjct: 1196 ILEILRF-----IRREKEIAETR---FEVAQVESLRYRQRVE--------LLERELQELQ 1239 Query: 756 RNIVSRKEKISALKK-QANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 814 ++ + +EK+ K A H + E + V E N ML+ EKE L E+ + Sbjct: 1240 DSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNK---MLREEKERL---EQDLQQM 1293 Query: 815 SGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ-- 872 L+ + + E N + + + + + D + L SQ Sbjct: 1294 QA------KVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQK 1347 Query: 873 -PQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQ 931 P ++E+ + L E++ K L++ + R K + I+ +S T +++ L + Sbjct: 1348 DPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLK--AEIARSNASLTNNQNLIQSLKEDLNK 1405 Query: 932 SNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHY 991 + + L A D + + Q G R K+++ A + Sbjct: 1406 VRTEKETIQKDLDAKIIDIQEKVKTIT---QVKKIGRRYKTQYEELKAQQ---------- 1452 Query: 992 PDHSYKDQAFDTLSLDSSDSMETSISACS----PDNISSASTSNIARIEEMERLLKQAHA 1047 D+ +T + S D E +S + ++ A T + + ++E L K Sbjct: 1453 ------DKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSE 1506 Query: 1048 EKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRE 1100 ++T +E+ ++ + E R R+ L+ R +E RQ++ EKE K R+ Sbjct: 1507 KETEARNLQEQTVQLQS----ELSRLRQDLQDRTTQEEQLRQQITEKEEKTRK 1555 Score = 50.4 bits (119), Expect = 1e-05 Identities = 109/562 (19%), Positives = 221/562 (39%), Gaps = 88/562 (15%) Query: 395 LESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETIL 454 L L +A G +R+ + S + IS +++ H R E + + QRL L Sbjct: 504 LMELEEARGNH--VIRDEEVSSADISSSSEVISQHLVS----YRNIEELQQQNQRLLVAL 557 Query: 455 SLCAEYTKPDSRLSTGTTVEDVQ-KINK---ELEKLQLSDEESV-FEEALMSPDTRYRCH 509 E + + + +T + + ++Q K+ ELE+L+ S + + ++++ YR Sbjct: 558 RELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRIL 617 Query: 510 RKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP-PSSTFPKASSESSYL 568 + A SL S + TP+ + +S TP P P +A + L Sbjct: 618 LSQTTGVAIPLHASSLDDVSLAS-TPKRPSTSQTVS----TPAPVPVIESTEAIEAKAAL 672 Query: 569 SILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDM---- 624 L + E +E+ E E+ LE+L++++ D+ Q + +LD Sbjct: 673 KQLQEIFENYKKEKAENEKIQNEQ--------LEKLQEQVTDLRSQNTKISTQLDFASKR 724 Query: 625 -------------ECALLDGEQKSETTELMKEKEILDHL-------NRKIAELE---KNI 661 E L + T K+++I++ + N K+A E +N+ Sbjct: 725 YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784 Query: 662 VGEKTKEK---VKLDAEREKL---ERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLL 715 EK K V+L +RE L +R Q L + E + +Q+L + L Sbjct: 785 KKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKL 844 Query: 716 DVESKHFE---------------DLEFQ------QLEHESRLDEEKENLTQQLLREVAEY 754 + E H + +L+ Q QL+ E+ L + L + +E+A Sbjct: 845 EHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATL 904 Query: 755 QRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNL-EKKYSS 813 ++++ + + ++++ Q Q + +E + ++L+ L++ +E + +L E+ +S Sbjct: 905 KQHLSNMEVQVASQSSQRTGKGQPSNKE------DVDDLVSQLRQTEEQVNDLKERLKTS 958 Query: 814 LSGGKGFPVNPNTLKEGYISVNEINEPCGNS--TNLSPSTQFPADADAVATEPATAVLAS 871 S + + +L+E ++ E + L S +F + E Sbjct: 959 TSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQEL 1018 Query: 872 QPQSKEHFRSLEERKKQHKEGL 893 Q + S+E++ + K+ L Sbjct: 1019 QDDKRRAIESMEQQLSELKKTL 1040 Score = 50.4 bits (119), Expect = 1e-05 Identities = 75/415 (18%), Positives = 183/415 (44%), Gaps = 38/415 (9%) Query: 397 SLRQASGTPQPA-LRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRL-ETIL 454 S Q TP P + E +I + + L + ++E+ ++++ + ++L E + Sbjct: 646 STSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVT 705 Query: 455 SLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 514 L ++ TK ++L + ++ + N E + +++ S+ E T + + + Sbjct: 706 DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREIT---SLHERNQKLTATTQKQEQIINT 762 Query: 515 PDADLASCGSLSQSSASFFTPRSTRNDELLSDLT--RTPPPPSSTFPKASSESSYLSILP 572 DL G+ + + + + + ++ + L+ R S + ++ L+ L Sbjct: 763 MTQDLR--GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL- 819 Query: 573 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 632 +T +GI E ++ + + + + LK+K+++ +Q R LD++ + Sbjct: 820 QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQ 879 Query: 633 QKSETTELMKEKEILDHLNRKIAELEKNI------VGEKTKEKV-------KLDAE---- 675 +ET + KE+L + ++IA L++++ V ++ ++ K D + Sbjct: 880 LDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVS 939 Query: 676 --REKLERLQELYSEQKTQLDNCP--ESMREQLQQQLKRDADLLD-----VESKHFEDLE 726 R+ E++ +L KT N ++M L++ L ++ + + +E + E E Sbjct: 940 QLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAE 999 Query: 727 FQ-QLEHE-SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQA 779 FQ QLE + +++EK+ L R + ++ + K+ +S+++ + +Q+A Sbjct: 1000 FQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRA 1054 Score = 48.5 bits (114), Expect = 4e-05 Identities = 145/712 (20%), Positives = 266/712 (37%), Gaps = 110/712 (15%) Query: 430 RRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLS 489 +RQREE R Q+ +LE + + + + ++V +++ N+ +E +Q+ Sbjct: 438 KRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSV--LERDNRRME-IQVK 494 Query: 490 DEESVFEEALMSPDTRYRCH--RKDSLPDADLASCGS-LSQSSASFFTPRSTRNDELLSD 546 D LM + H R + + AD++S +SQ S+ RN E L Sbjct: 495 DLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSY------RNIEELQQ 548 Query: 547 LTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQ 606 L L + E E++ + + E ++ + + L EL+Q Sbjct: 549 ----------------QNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQ 592 Query: 607 KIKDINDQM---DESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVG 663 K QM D R+ DM LL S+TT + + +A K Sbjct: 593 LRKSRQHQMQLVDSIVRQRDMYRILL-----SQTTGVAIPLHASSLDDVSLASTPKRPST 647 Query: 664 EKTK---------EKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADL 714 +T E + + L++LQE++ K + + EQL++ ++ DL Sbjct: 648 SQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDL 707 Query: 715 LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVS---RKEKISALKKQ 771 +K L+F +E D V Y+R I S R +K++A ++ Sbjct: 708 RSQNTKISTQLDFASKRYEMLQD------------NVEGYRREITSLHERNQKLTATTQK 755 Query: 772 ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGY 831 I+ ++ ++ N + + + ENL EK+ LS V + +E Sbjct: 756 QEQIINTMTQD----LRGANEKLAVAEVRAENL-KKEKEMLKLS-----EVRLSQQRESL 805 Query: 832 ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKE 891 ++ E G + L+ + TE L+SQ + EH + KK+ + Sbjct: 806 LA-----EQRGQNLLLTNLQTIQGILERSETETKQR-LSSQIEKLEH--EISHLKKKLEN 857 Query: 892 GLYLSDTLPR----------KKTTSSISPHFSSATMGRS-----ITPKAHLPLGQSNSCG 936 + TL R ++ + + H ++ + ++ T K HL SN Sbjct: 858 EVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHL----SNMEV 913 Query: 937 SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNR-TASESNVYLNSFHYPDHS 995 V S K S + Q+ + Q ++ R S SNV Sbjct: 914 QVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNV----------- 962 Query: 996 YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLES 1055 + QA T SL+ S + E ++ NI + ++E+ L + EK L + Sbjct: 963 EQYQAMVT-SLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDD 1021 Query: 1056 REREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQAR 1107 + R +E+ ++ L E K+ ++ +QE + + E + R + QA+ Sbjct: 1022 KRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK 1073 Score = 48.1 bits (113), Expect = 5e-05 Identities = 50/230 (21%), Positives = 94/230 (40%), Gaps = 48/230 (20%) Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELM 641 ++++EL ++ I I + K++++ + + L E L + K +L Sbjct: 94 EKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLK 153 Query: 642 KEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMR 701 + L K+ EL+ + V K +EK +LE+ +EL Q T L+ Sbjct: 154 ESNTTKGELQLKLDELQASDVSVKYREK--------RLEQEKELLHSQNTWLNT------ 199 Query: 702 EQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSR 761 +LK D L L EK N E+ E + N+ ++ Sbjct: 200 -----ELKTKTDEL------------------LALGREKGN-------EILELKCNLENK 229 Query: 762 KEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKY 811 KE++S L++Q N + + +H K +L+ L+ KE ++E+K+ Sbjct: 230 KEEVSRLEEQMNGL----KTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF 275 Score = 42.4 bits (98), Expect = 0.003 Identities = 46/201 (22%), Positives = 90/201 (44%), Gaps = 17/201 (8%) Query: 578 ISEEQRSQELAAMEETRIVILNNLEELKQKIKDIND----QMDESFRELDMECALLDGEQ 633 + E Q +E ET+ L + E QK + + E +L E + L + Sbjct: 1473 VQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDL 1532 Query: 634 KSETTELMKEKEILDHLNRKIAELEKNIVGEKTK------EKVKLDAEREKLERLQELYS 687 + TT+ E+++ + K + K IV K+K K +L E E+L++ Sbjct: 1533 QDRTTQ---EEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALD 1589 Query: 688 EQKTQLDNCPESMREQLQQQLKR-DADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQ 746 +QK +LD +++ Q + ++ R + +L + + +H E + Q E +++ E++ +T Sbjct: 1590 QQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQ-EPSNKVPEQQRQIT-- 1646 Query: 747 LLREVAEYQRNIVSRKEKISA 767 L A +R I S + +A Sbjct: 1647 LKTTPASGERGIASTSDPPTA 1667 Score = 37.4 bits (85), Expect = 0.091 Identities = 87/416 (20%), Positives = 155/416 (37%), Gaps = 77/416 (18%) Query: 689 QKTQLDNCPESMREQLQQQLKRDADLLD-VESKHFE---DLEFQQLEHESRLDEEKENLT 744 ++T+L+ P+S++ +L++ L +D ++ +H + + E Q E E RL +E L Sbjct: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69 Query: 745 QQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE---QDHFVKEKNNLIMMLQREK 801 + RE + + ++ AL ++ + R Q F + K L+ EK Sbjct: 70 NE-TRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEE----LEAEK 124 Query: 802 ENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVA 861 +L ++ S L+ V +NE S Q D Sbjct: 125 RDLIRTNERLS------------QELEYLTEDVKRLNEKLKESNTTKGELQLKLD----- 167 Query: 862 TEPATAVLASQPQSKEHFRSLEERKK-QHKEGLYLSDTLPRKKTTSSISPHFSSATMGRS 920 + AS K + LE+ K+ H + +L+ L K T + Sbjct: 168 -----ELQASDVSVKYREKRLEQEKELLHSQNTWLNTEL--KTKTDEL------------ 208 Query: 921 ITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKS-EFYNRTA 979 L LG+ +L K E R+ N + S H QK E Sbjct: 209 ------LALGREKG-NEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKL 261 Query: 980 SESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIAR-IEEM 1038 E+ S H+ L++ + + + D S A ++ + R +EE+ Sbjct: 262 KEAKEQQASMEEKFHN---------ELNAHIKLSNLYKSAADD--SEAKSNELTRAVEEL 310 Query: 1039 ERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK--RLQEETSQRQKLI 1092 +LLK+A E + ++ E+E K +E +E+LEK RL++E L+ Sbjct: 311 HKLLKEA-GEANKAIQDHLLEVEQSKDQME-----KEMLEKIGRLEKELENANDLL 360 Score = 36.2 bits (82), Expect = 0.20 Identities = 89/445 (20%), Positives = 173/445 (38%), Gaps = 56/445 (12%) Query: 409 LRERKSSISSISGRDDLMDYHRRQR----EERLREQEMERLERQRLETILSLCAEYTKPD 464 L +++S I + GR + Q+ E+RL + ERL + E SL E K + Sbjct: 29 LADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQ-ERLVNETREC-QSLRLELEKLN 86 Query: 465 SRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGS 524 ++L T + NKELE ++ + ++ A+ S TR + + DL Sbjct: 87 NQLKALT------EKNKELE---IAQDRNI---AIQSQFTRTK--EELEAEKRDLIRTNE 132 Query: 525 LSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS 584 + T R +E L + T + + + K E E S Sbjct: 133 RLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHS 192 Query: 585 Q-------------ELAAMEETR----IVILNNLEELKQKIKDINDQMD-----ESFREL 622 Q EL A+ + + + NLE K+++ + +QM+ + Sbjct: 193 QNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQK 252 Query: 623 DMECALLDGEQKSETTELMKEK---EILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKL 679 +E L ++ E M+EK E+ H+ K++ L K+ + + +L E+L Sbjct: 253 HVEDLLTKLKEAKEQQASMEEKFHNELNAHI--KLSNLYKSAADDSEAKSNELTRAVEEL 310 Query: 680 ERLQELYSEQKTQLDNC---PESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRL 736 +L + E + + E ++Q+++++ L+ E ++ DL + L Sbjct: 311 HKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAIL 370 Query: 737 DEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIV------QQAQREQDHFVKEK 790 EE+ VA+ + + E +A + + ++ ++ + D VKE Sbjct: 371 SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV 430 Query: 791 NNLIMMLQREKENLCNLEKKYSSLS 815 +L+R++E +K +SLS Sbjct: 431 EAKAPILKRQREEYERAQKAVASLS 455 Score = 33.5 bits (75), Expect = 1.3 Identities = 57/318 (17%), Positives = 120/318 (37%), Gaps = 30/318 (9%) Query: 410 RERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLST 469 + R + S D +Y + E+ + + +++L E I L AE + ++ L+ Sbjct: 1336 KARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLT----EEIGRLKAEIARSNASLTN 1391 Query: 470 GTTV-----EDVQKINKELEKLQLSDEESVFE--------EALMSPDTRYRCH------R 510 + ED+ K+ E E +Q + + + + RY+ + Sbjct: 1392 NQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQ 1451 Query: 511 KDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSI 570 +D + + S G + S EL L + S + + LS Sbjct: 1452 QDKVMETSAQSSGDHQEQHVSV-----QEMQELKETLNQAETKSKSLESQVENLQKTLSE 1506 Query: 571 LPKTPEGISEE--QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECAL 628 + E+ Q EL+ + + E+L+Q+I + ++ ++ + A Sbjct: 1507 KETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAH 1566 Query: 629 LDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSE 688 L G + T E + K+ L+++ EL+ I K++ + ++ +L QE + E Sbjct: 1567 LAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLE 1626 Query: 689 QKTQLDNCPESMREQLQQ 706 Q+ + + EQ +Q Sbjct: 1627 QRDEPQEPSNKVPEQQRQ 1644 Score = 31.2 bits (69), Expect = 6.5 Identities = 27/107 (25%), Positives = 48/107 (44%), Gaps = 7/107 (6%) Query: 1010 DSMETSISACSPDN--ISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRAL 1067 + + + A + N + A NIA + R ++ AEK L+ + ER + + Sbjct: 83 EKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLT 142 Query: 1068 EEEKRRREILEKRLQEETSQRQKLIEKE-----VKIRERQRAQARPL 1109 E+ KR E L++ + + KL E + VK RE++ Q + L Sbjct: 143 EDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKEL 189 >gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] Length = 3907 Score = 61.2 bits (147), Expect = 6e-09 Identities = 124/702 (17%), Positives = 289/702 (41%), Gaps = 127/702 (18%) Query: 475 DVQKINKELEKLQLS------DEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528 +++++N+ELE+++++ + FE A+ D G ++Q Sbjct: 170 EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRD-------------------GIITQL 210 Query: 529 SASFFTPRSTRNDELLSDLTRTPPPP-----------SSTFPKASSESSYLSILPKTPEG 577 +A+ R +++ + L T S T ++ S+ +L + Sbjct: 211 TANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQI 270 Query: 578 ISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSET 637 ++ +Q+ +E + LE+ ++K +D Q+ SF + ++ ++ ++K E Sbjct: 271 LTHQQQLEEQDHL----------LEDYQKKKEDFTMQI--SFLQEKIKVYEMEQDKKVEN 318 Query: 638 T---ELMKEKEILDHLNRKIAELEKNIVGEKTK----EKVKLDAEREKLERLQELYSEQK 690 + E+ +++ I++ LN KI E EK + K K +K+ + + + +++ QE+ K Sbjct: 319 SNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEI-KNMK 377 Query: 691 TQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLRE 750 +L N + R+ ++ + + +++ ++ +D +F+ + R+++E + +QL E Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET-DIVQRMEQETQRKLEQLRAE 436 Query: 751 VAE-YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEK 809 + E Y + IV K+++ H+ Q + M R K + N + Sbjct: 437 LDEMYGQQIVQMKQELIR-----QHMAQMEE---------------MKTRHKGEMENALR 476 Query: 810 KYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVL 869 YS+++ VN + +K +++NE+N ++ S + + + E Sbjct: 477 SYSNIT------VNEDQIKLMNVAINELNIKLQDTN--SQKEKLKEELGLILEEKCALQR 528 Query: 870 ASQPQSKEHFRSLEE----RKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKA 925 + +E S E+ R+ ++ L++ T + SA+ R Sbjct: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588 Query: 926 H----------LPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFY 975 H L + + +VL + + E R ++H++ ++ E Sbjct: 589 HEAEVTNYKIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647 Query: 976 NRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTS---NI 1032 +R E HY Q D L + S +ET DN+ + I Sbjct: 648 HRINIEKLKDNLGIHYK------QQIDGLQNEMSQKIETM--QFEKDNLITKQNQLILEI 699 Query: 1033 ARIEEMERLLKQAHAEKTRL-----------LESREREMEAKKRALEEEKRRREILEKRL 1081 ++++++++ L + +E+ L L E+E ++ ++E + + E+LEK++ Sbjct: 700 SKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQM 759 Query: 1082 QE-ETSQRQKLIEKEVK---IRERQRAQARPLTRYLPVRKED 1119 +E E ++K + E + +++ ++ L + PV +E+ Sbjct: 760 KEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEE 801 Score = 61.2 bits (147), Expect = 6e-09 Identities = 136/702 (19%), Positives = 275/702 (39%), Gaps = 90/702 (12%) Query: 422 RDDLMDYHRRQREERLREQEMER-------LERQRLETILSLCAEYTKPDSRLSTGTTVE 474 RDDL Q++ + E ++E LE+++ ++ L + + +L Sbjct: 2016 RDDL------QKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069 Query: 475 DVQKINKELEKLQLSDEESVFEEAL-----MSPDTRYRCHRKDSLPD---ADLASCGSLS 526 D Q I++E E+ E E+ L P + ++ + L + C L Sbjct: 2070 DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129 Query: 527 QSSASFFTPRSTRNDEL------LSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISE 580 S RN+E+ + +L + + TF K + ++ K PE E Sbjct: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK-PELSLE 2188 Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640 Q E A++ I NLEE ++ ++ + +E ++L M+ + QK E+T Sbjct: 2189 VQLQAERDAIDRKEKEI-TNLEEQLEQFREELENKNEEVQQLHMQLEI----QKKESTTR 2243 Query: 641 MKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESM 700 ++E E + L + ++EK + K + + + + ++ E++ ++D E + Sbjct: 2244 LQELEQENKLFKD--DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV 2301 Query: 701 REQLQQQLKRDADLLDVESKH--FEDLEFQ---QLEHESRLDEEKENLTQQLLREVAEYQ 755 + LQQQLK D +E K+ DLE Q + + + +E +QL + + Q Sbjct: 2302 TK-LQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQ 2360 Query: 756 RNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS 815 + + + +K S + + + D + EK L ++ E + ++ + Sbjct: 2361 QELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETN 2420 Query: 816 GGKGFPVNPNT-----LKEGYISVNEINEPCGNSTNLSPS--TQFPADADAVATEPATAV 868 F +N T LK SV +I NS N++ ++ + + V TE A Sbjct: 2421 ----FKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKS 2476 Query: 869 LASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLP 928 L +++ +F+S +++ +G ++ + S++S T Sbjct: 2477 L----ENQTYFKSF----EENGKGSIINLETRLLQLESTVSAKDLELTQ----------- 2517 Query: 929 LGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNS 988 KD + + Q+ ++ E A S + L + Sbjct: 2518 --------------CYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEA 2563 Query: 989 FHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAE 1048 +++ Q T+S + + +++ D + S ++ RI E+E + + H Sbjct: 2564 VQ--EYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMH-- 2619 Query: 1049 KTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1090 T L+ +E+ A+K LE+EK+ E+ + E QR+K Sbjct: 2620 -TSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK 2660 Score = 57.4 bits (137), Expect = 8e-08 Identities = 65/275 (23%), Positives = 126/275 (45%), Gaps = 46/275 (16%) Query: 581 EQRSQELAAMEETRIVILNNLEELK---QKIKDINDQMDESFRELDMECALLDGEQKSET 637 ++++ + +E+ + N L+EL+ Q+I++ + + + E ++ + ET Sbjct: 1939 QEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQET 1998 Query: 638 TELMKEK--------EILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQ 689 +LMKEK ++ D L +++ LE ++ + ++ ++ E+EK L +L +Q Sbjct: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRF---IELEQEKNTELMDL-RQQ 2054 Query: 690 KTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL----------EHESRLDE- 738 L+ E MR+ L +Q DV + + LE QQL EH++R E Sbjct: 2055 NQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE-QQLKVVPRFQPISEHQTREVEQ 2113 Query: 739 ------EKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ---------QAQREQ 783 EK + +LL + QR+I R E+I L+ + + Q Q ++ Sbjct: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDR 2173 Query: 784 DHF----VKEKNNLIMMLQREKENLCNLEKKYSSL 814 HF K + +L + LQ E++ + EK+ ++L Sbjct: 2174 KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNL 2208 Score = 53.9 bits (128), Expect = 9e-07 Identities = 122/606 (20%), Positives = 237/606 (39%), Gaps = 111/606 (18%) Query: 394 DLESLRQAS--GTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 451 +LE+L+Q S G + R SS + +G ++ + E+ +E+E++R Sbjct: 1659 ELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVE----EQTFKEKELDRKPEDVPP 1714 Query: 452 TILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRK 511 ILS + R + + KI E+ K + EE++ L D + Sbjct: 1715 EILS--------NERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSS 1766 Query: 512 DSL-----PDADLASCGS------LSQSSASFFTPRSTRND------------ELLSDLT 548 SL +A + SC +S S+ RND EL L Sbjct: 1767 ASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLV 1826 Query: 549 R-----TPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIV------- 596 R T P + + S + + K E ISE E A + +T ++ Sbjct: 1827 RSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQK 1886 Query: 597 -----ILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETT---ELMKEKEILD 648 L EEL++++ + + ++ EL ++DG +T ++ ++ +I+D Sbjct: 1887 QEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIID 1946 Query: 649 HLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYS------------------EQK 690 L +++ N + E E+ ++ ERE L R +E ++K Sbjct: 1947 RLEQELL-CASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEK 2005 Query: 691 TQLDNCPESMREQLQQQLK-----------RDADLLDVESKHFEDLEFQQLEHESRLDEE 739 ++ E +R+ LQ+Q+K R +L ++ DL Q E +L++ Sbjct: 2006 LEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKM 2065 Query: 740 KENLTQQLL-----REV-------AEYQRNIVSRKEKIS-----ALKKQANHIVQQAQRE 782 ++ L +Q + R+V E Q +V R + IS +++ ANH+ ++ + Sbjct: 2066 RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKC 2125 Query: 783 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 842 + + K L +Q E + LE + L + V+ +T ++ + + Sbjct: 2126 SE-LLLSKEQLQRDIQERNEEIEKLEFRVRELE--QALLVSADTFQK--VEDRKHFGAVE 2180 Query: 843 NSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRK 902 LS Q A+ DA+ + + + + E FR E K + + L++ + +K Sbjct: 2181 AKPELSLEVQLQAERDAI--DRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK 2238 Query: 903 KTTSSI 908 ++T+ + Sbjct: 2239 ESTTRL 2244 Score = 51.6 bits (122), Expect = 5e-06 Identities = 101/498 (20%), Positives = 202/498 (40%), Gaps = 95/498 (19%) Query: 390 FDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLER 447 + + + S++Q S +P L ERK+ I++IS DL+ + QRE + + Q E Sbjct: 2965 YSDGEDHSIQQVS---EPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSD 3021 Query: 448 QRLETILSLCAEYTKPDSRL---------STGTT-------------VEDVQKINKELEK 485 R E +L+L + + S L + GTT E + +E Sbjct: 3022 WRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMEC 3081 Query: 486 LQLSDEESVFEE------ALMSPDTRYRCHRKDSLPDADLASCGSLSQSS--------AS 531 LQ +D S+ E + + ++ P +L + S S Sbjct: 3082 LQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3141 Query: 532 FFTPRSTRND-----------ELLSDLTRTPPPPSSTFPKASS-----ESSYLSILPKTP 575 R+T EL S+L +T +T E+ L + KT Sbjct: 3142 SMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTD 3201 Query: 576 EG-------ISEEQRSQELA-AMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECA 627 E SE+++S+EL A+E+ + + + E K++++D+ + ES ++ +++ Sbjct: 3202 EVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSL-ESQKQRNLQLN 3260 Query: 628 LL---------DGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVK-----LD 673 LL + +QK E+ ++ + ++ + R LE ++ E K +++ LD Sbjct: 3261 LLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGR---NLELQVLLESEKVRIREMSSTLD 3317 Query: 674 AEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHE 733 ERE +LQ +++ E + ++LQ+QL E KH +E + Sbjct: 3318 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL---------EEKHSRIVELLNETEK 3368 Query: 734 SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNL 793 +LD + T+Q + + + R + +++ + ++ H +Q + ++EK Sbjct: 3369 YKLDSLQ---TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425 Query: 794 IMMLQREKENLCNLEKKY 811 + L E + L + +++ Sbjct: 3426 VYKLDLEGQRLQGIMQEF 3443 Score = 50.4 bits (119), Expect = 1e-05 Identities = 80/453 (17%), Positives = 196/453 (43%), Gaps = 51/453 (11%) Query: 388 VEFDEADLESLRQASGTPQPALRERKSSISSISG-RDDLMDYHRRQREERLREQ------ 440 + F ++ RQ + L E S+S++ + +++ ++E L+ + Sbjct: 537 LSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNY 596 Query: 441 --EMERLERQRLETILSLCAEYTKPD-SRLSTGTTVEDVQKINKELEKLQLSDEESVFEE 497 ++E LE+++ +L AE + + RL T ++++K E L++ ++ E+ Sbjct: 597 KIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINI-EK 654 Query: 498 ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSST 557 + Y+ + D L + ++ + T + ++L+ ++++ S Sbjct: 655 LKDNLGIHYK-QQIDGLQNEMSQKIETMQFEKDNLIT----KQNQLILEISKLKDLQQSL 709 Query: 558 FPKASSESSY-LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMD 616 S E + ++ L K E + +E++ + E + + L L++++K+ + + Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL--LEKQMKEKENDLQ 767 Query: 617 ESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAER 676 E F +L+ E ++L E+K+ +++K ++ +++ E+ I + K K K Sbjct: 768 EKFAQLEAENSILKDEKKT-LEDMLK-------IHTPVSQEERLIFLDSIKSKSKDSVWE 819 Query: 677 EKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHE-SR 735 +++E L E + K Q QL +++++ + K+FE + +Q+L+ E + Sbjct: 820 KEIEILIEENEDLKQQC--------IQLNEEIEKQRNTFSFAEKNFE-VNYQELQEEYAC 870 Query: 736 LDEEKENLTQQLLREVAEYQRNIVSRKEKI-------------SALKKQANHIVQQAQRE 782 L + K++L ++ EY+ + + E++ S++ + V + Sbjct: 871 LLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEM 930 Query: 783 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS 815 + K+ L+ L+ K L ++ S LS Sbjct: 931 GEVVEKDTTELMEKLEVTKREKLELSQRLSDLS 963 Score = 46.6 bits (109), Expect = 1e-04 Identities = 100/565 (17%), Positives = 220/565 (38%), Gaps = 70/565 (12%) Query: 555 SSTFPKASSESSYLSILPKT--PEGISEEQR-------SQELAAMEETRIVILNN-LEEL 604 S+T SSE + S + +T P + E+ S++ A T + ++ + L Sbjct: 108 STTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGK 167 Query: 605 KQKIKDINDQMDE-----------SFRELDMECALLDGEQKSETTELMKEKEILDHLNRK 653 + +I+++N +++E +E + DG T L + + D R+ Sbjct: 168 QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMRE 227 Query: 654 IAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQL---QQQLKR 710 EL T++ KL + ++L+ + L + + ++Q+ QQQL+ Sbjct: 228 FLEL--------TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 279 Query: 711 DADLLDVESKHFEDLEFQ-----------QLEHESRLD-------EEKENLTQQLLREVA 752 LL+ K ED Q ++E + +++ +EKE + ++L ++ Sbjct: 280 QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKII 339 Query: 753 EYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYS 812 E ++ + K+K++ K + +Q ++ K L Q+E+++ +++ Sbjct: 340 EEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMG 399 Query: 813 SLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ 872 ++ + K+ + + Q A+ D + + V Q Sbjct: 400 TVE-----ELQKRNHKDSQFETDIVQRM--EQETQRKLEQLRAELDEMYGQ--QIVQMKQ 450 Query: 873 PQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQS 932 ++H +EE K +HK + ++ S+I+ + + + ++ L + Sbjct: 451 ELIRQHMAQMEEMKTRHK-----GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDT 505 Query: 933 NSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYP 992 NS L L + ++ + + +++S R++ + +T +E LN H Sbjct: 506 NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS-REQIQRARQTIAEQESKLNEAHKS 564 Query: 993 DHSYKDQAFDTLSL-DSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAE--- 1048 + +D + +S +S +E A + + ++R+ + AE Sbjct: 565 LSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELER 624 Query: 1049 -KTRLLESREREMEAKKRALEEEKR 1072 +T+LL S E E+ K LE E R Sbjct: 625 LRTQLLFSHEEELSKLKEDLEIEHR 649 Score = 42.4 bits (98), Expect = 0.003 Identities = 56/246 (22%), Positives = 110/246 (44%), Gaps = 53/246 (21%) Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640 +++ Q M + +IV L + E K ++ E+ +E C Q ++T Sbjct: 2526 QEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFC------QDNQTISS 2579 Query: 641 MKEKEILDHLNR---------------KIAELEKNIVGEKT-----KEKVKLDAEREKLE 680 E+ + +LN+ +I+ELE +V T KE+V++ AE+ LE Sbjct: 2580 EPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEI-AEKNVLE 2638 Query: 681 RLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV---------ESKHFEDLEFQQLE 731 + ++L QK L+ + RE+ +++ +D ++L ES F +LE + E Sbjct: 2639 KEKKLLELQKL-LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE 2697 Query: 732 HES-------------RLDEE---KENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI 775 + +L EE KE L +++++ + ++ KEK+S L+K+ Sbjct: 2698 SVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE 2757 Query: 776 VQQAQR 781 VQ++++ Sbjct: 2758 VQESKK 2763 Score = 41.6 bits (96), Expect = 0.005 Identities = 84/429 (19%), Positives = 161/429 (37%), Gaps = 106/429 (24%) Query: 431 RQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKL--QL 488 +Q E LR+ M ++ERQR ED +++ +E+++L QL Sbjct: 1602 QQATELLRQAHMRQMERQR------------------------EDQEQLQEEIKRLNRQL 1637 Query: 489 SDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASFFTPRSTRNDELL 544 + S+ E L+S R ++L LA C L SS T N + Sbjct: 1638 AQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ--TQNGNENQGEV 1695 Query: 545 SDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEEL 604 + TF + L + PE + E S E A+++ +L L E+ Sbjct: 1696 EE---------QTFKEKE--------LDRKPEDVPPEILSNERYALQKANNRLLKILLEV 1738 Query: 605 KQKIKDINDQ--------MDESFRELDMECALLDGEQKSETTELMKE-------KEILDH 649 + + + +D S + + E ++ + E + I + Sbjct: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798 Query: 650 LNRKIAELEKNIVGEKTKEKVKL--------------DAEREKL------------ERLQ 683 + + N+ + T+E +L D E E+L E+L Sbjct: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLL 1858 Query: 684 ELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEE---- 739 E SE +QL++ + E +++ ++ + ES ++ ++L ESR E+ Sbjct: 1859 EAISETSSQLEHAKVTQTELMRESFRQKQEA--TESLKCQEELRERLHEESRAREQLAVE 1916 Query: 740 ---KENLTQQLLREVAEYQRNIVSRKEKISALKKQ---ANHIVQQAQREQDHFVKEKNNL 793 E + E ++R I + + I L+++ A++ +Q+ + EQ +E+ Sbjct: 1917 LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE-- 1974 Query: 794 IMMLQREKE 802 +L R+KE Sbjct: 1975 --LLSRQKE 1981 Score = 40.8 bits (94), Expect = 0.008 Identities = 75/349 (21%), Positives = 140/349 (40%), Gaps = 45/349 (12%) Query: 474 EDVQKINKE--LEKLQLSDEESV-FEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSA 530 E QKI + L QLS+E+ E ++ + R S D + L S Sbjct: 3272 ESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3331 Query: 531 SFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS---QEL 587 + + +++LL +L + S + +E+ + E+ R + L Sbjct: 3332 TGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTL 3391 Query: 588 AAMEETRIVILNNLEELKQKIKDINDQMDESFRE---LDMECALLDG------EQKSETT 638 +E + EL+ K++D+ Q++E ++ LD+E L G +Q+ E Sbjct: 3392 QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3451 Query: 639 ELMKEKEIL-DHLNRKIA-----------ELEKNIVGEKTKEK-----VKLDAE----RE 677 E + + IL +LN L++ I GE TKE ++++ Sbjct: 3452 EKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGE-TKESNYAKLIEMNGGGTGCNH 3510 Query: 678 KLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK------HFEDLEFQQLE 731 +LE +++ ++L P+ E+LQ + D D + V+ + L QQ E Sbjct: 3511 ELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGE 3570 Query: 732 HESRLDEEKE--NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ 778 S + +LT++LLR+ AE +I E+ + L+ + +Q Sbjct: 3571 EPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3619 Score = 39.3 bits (90), Expect = 0.024 Identities = 97/488 (19%), Positives = 190/488 (38%), Gaps = 69/488 (14%) Query: 363 NPSH-----SLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS 417 +P+H S LAG+ + R V + L+ L++ + A+++R I+ Sbjct: 153 SPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEF----EAAIKQRDGIIT 208 Query: 418 SISGRDDLMDYHRRQREERLRE---------------QEMERLERQRLETILSLCAEYTK 462 ++ + RR+++E +RE Q+++ E R T S A+ + Sbjct: 209 QLTAN---LQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQ 265 Query: 463 PDSRLSTGTT--------VEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 514 ++ T +ED QK KE +Q+S + + M D + K+ + Sbjct: 266 AKQQILTHQQQLEEQDHLLEDYQK-KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 324 Query: 515 PDAD-----LASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLS 569 + + L + + + T D+LL +L + E + Sbjct: 325 QEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTN-- 382 Query: 570 ILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALL 629 K E S E+ Q + +EE + N ++ + + + E+ R+L+ A L Sbjct: 383 --SKQKERQSSEEIKQLMGTVEELQ---KRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437 Query: 630 DGEQKSETTELMKEKEILDHL-------NRKIAELEK------NIVGEKTKEKVKLDAER 676 D E + MK++ I H+ R E+E NI + + K+ A Sbjct: 438 D-EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN 496 Query: 677 EKLERLQELYSEQKTQLDNCPESMREQ--LQQQLKRDADLLDVESKHFEDLEFQQLEHES 734 E +LQ+ S+++ + + E+ LQ+QL+ + L + + E ES Sbjct: 497 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQES 556 Query: 735 RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLI 794 +L+E ++L+ V + + IVS E L+ + V + + + KEKN ++ Sbjct: 557 KLNEAHKSLST-----VEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611 Query: 795 MMLQREKE 802 + +E Sbjct: 612 DRMAESQE 619 Score = 38.5 bits (88), Expect = 0.041 Identities = 100/540 (18%), Positives = 212/540 (39%), Gaps = 72/540 (13%) Query: 603 ELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN-I 661 + K++ K ++ ++ E +E+ + S+ ++ + K+ + ++ ++ +K I Sbjct: 1509 KFKEEFKPLSKELGEHGKEILLS--------NSDPHDIPESKDCVLTISEEMFSKDKTFI 1560 Query: 662 VGEKTKEKVK---LDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV- 717 V + +++ +DA R+ + ++L E MR++L +Q + ++ Sbjct: 1561 VRQSIHDEISVSSMDASRQLMLNEEQL------------EDMRQELVRQYQEHQQATELL 1608 Query: 718 ESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ 777 H +E +Q E + +L EE + L +QL + + N+VS +E++ + +A + Sbjct: 1609 RQAHMRQME-RQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLS 1667 Query: 778 QAQREQDHFVKEKNNLIMMLQREKENLCNLEK---KYSSLSGGKGFPVNPNTLKEGYISV 834 A RE+ E N Q EN +E+ K L K V P L ++ Sbjct: 1668 LAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELD-RKPEDVPPEILSNERYAL 1724 Query: 835 NEINE------------PCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSL 882 + N + D + + A+ + S+ ++ Sbjct: 1725 QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVH 1784 Query: 883 EERKKQHKEGL--YLSDTLPR----------KKTTSSISPHFSSATMGRSITPK-AHLPL 929 EE + E + Y +PR ++ T S G I P+ L L Sbjct: 1785 EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELML 1844 Query: 930 GQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSF 989 S+ + + L A+++ S + + M E RQK E A+ES Sbjct: 1845 NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQE-----ATESLKCQEEL 1899 Query: 990 HYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEK 1049 H + +A + L+++ S + D + T +I+E ++ + E Sbjct: 1900 RERLHE-ESRAREQLAVELSKAEGVI------DGYADEKTLFERQIQEKTDIIDRLEQE- 1951 Query: 1050 TRLLESREREMEAKKRALEEEKRRREILEKRLQEETS--QRQKLIEKEVKIRERQRAQAR 1107 +R +E+EA+++ ++EE+ ++ ++ E ++Q L E E ++E+ Q + Sbjct: 1952 LLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011 Score = 33.1 bits (74), Expect = 1.7 Identities = 32/154 (20%), Positives = 74/154 (48%), Gaps = 22/154 (14%) Query: 590 MEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDH 649 ++E +V N+ L++ + + D + E+ +L ++L+ E ++E E K+ + + Sbjct: 2715 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKL----SILEKEDETEVQE-SKKACMFEP 2769 Query: 650 LNRKIAELEKNIVGEKTKEKVKLDAEREKLERL-----------QELYSEQKTQLDNCPE 698 L K+++ + +T +K+ + + + L E SE+ T++ + Sbjct: 2770 LPIKLSKS----IASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFT 2825 Query: 699 SMREQLQQQLKRDADLLDVESKHFEDLEFQQLEH 732 E++Q+ A++LD+ES+H + E + EH Sbjct: 2826 EKIEKMQEL--HAAEILDMESRHISETETLKREH 2857 Score = 32.7 bits (73), Expect = 2.2 Identities = 80/406 (19%), Positives = 151/406 (37%), Gaps = 64/406 (15%) Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645 E+ +E +LN + E K+ + ++ + + + L GE+ L KE+ Sbjct: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEEN-----LPKEET 1302 Query: 646 ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLE-RLQELYSEQKTQLDNCPESMREQL 704 ++ ++ LE V K+K D E+ KLE ++QEL ES+ L Sbjct: 1303 EFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL------------ESLISSL 1350 Query: 705 QQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEK 764 QQQLK + E + ++L+ S ++ ++ QR + Sbjct: 1351 QQQLKETEQNYEAEIHCLQ----KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPG--- 1403 Query: 765 ISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE-----KENLCNL----------EK 809 S +KK + ++ + + VKE+ N++ +L+++ +E + + + Sbjct: 1404 -SCVKKNIDGTIEFS---GEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQT 1459 Query: 810 KYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVL 869 + S +SGG KE S + + C + + D T V Sbjct: 1460 ELSRISGG----------KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDV- 1508 Query: 870 ASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR-----KKTTSSISPHFSSATMGRSITPK 924 + KE F+ L + +H + + LS++ P K +IS S + Sbjct: 1509 ----KFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQS 1564 Query: 925 AHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQ 970 H + S+ S +D + + HQQ +E RQ Sbjct: 1565 IHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQ 1610 >gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] Length = 3899 Score = 61.2 bits (147), Expect = 6e-09 Identities = 124/702 (17%), Positives = 289/702 (41%), Gaps = 127/702 (18%) Query: 475 DVQKINKELEKLQLS------DEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528 +++++N+ELE+++++ + FE A+ D G ++Q Sbjct: 170 EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRD-------------------GIITQL 210 Query: 529 SASFFTPRSTRNDELLSDLTRTPPPP-----------SSTFPKASSESSYLSILPKTPEG 577 +A+ R +++ + L T S T ++ S+ +L + Sbjct: 211 TANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQI 270 Query: 578 ISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSET 637 ++ +Q+ +E + LE+ ++K +D Q+ SF + ++ ++ ++K E Sbjct: 271 LTHQQQLEEQDHL----------LEDYQKKKEDFTMQI--SFLQEKIKVYEMEQDKKVEN 318 Query: 638 T---ELMKEKEILDHLNRKIAELEKNIVGEKTK----EKVKLDAEREKLERLQELYSEQK 690 + E+ +++ I++ LN KI E EK + K K +K+ + + + +++ QE+ K Sbjct: 319 SNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEI-KNMK 377 Query: 691 TQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLRE 750 +L N + R+ ++ + + +++ ++ +D +F+ + R+++E + +QL E Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET-DIVQRMEQETQRKLEQLRAE 436 Query: 751 VAE-YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEK 809 + E Y + IV K+++ H+ Q + M R K + N + Sbjct: 437 LDEMYGQQIVQMKQELIR-----QHMAQMEE---------------MKTRHKGEMENALR 476 Query: 810 KYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVL 869 YS+++ VN + +K +++NE+N ++ S + + + E Sbjct: 477 SYSNIT------VNEDQIKLMNVAINELNIKLQDTN--SQKEKLKEELGLILEEKCALQR 528 Query: 870 ASQPQSKEHFRSLEE----RKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKA 925 + +E S E+ R+ ++ L++ T + SA+ R Sbjct: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588 Query: 926 H----------LPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFY 975 H L + + +VL + + E R ++H++ ++ E Sbjct: 589 HEAEVTNYKIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647 Query: 976 NRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTS---NI 1032 +R E HY Q D L + S +ET DN+ + I Sbjct: 648 HRINIEKLKDNLGIHYK------QQIDGLQNEMSQKIETM--QFEKDNLITKQNQLILEI 699 Query: 1033 ARIEEMERLLKQAHAEKTRL-----------LESREREMEAKKRALEEEKRRREILEKRL 1081 ++++++++ L + +E+ L L E+E ++ ++E + + E+LEK++ Sbjct: 700 SKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQM 759 Query: 1082 QE-ETSQRQKLIEKEVK---IRERQRAQARPLTRYLPVRKED 1119 +E E ++K + E + +++ ++ L + PV +E+ Sbjct: 760 KEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEE 801 Score = 58.2 bits (139), Expect = 5e-08 Identities = 64/267 (23%), Positives = 125/267 (46%), Gaps = 38/267 (14%) Query: 581 EQRSQELAAMEETRIVILNNLEELK---QKIKDINDQMDESFRELDMECALLDGEQKSET 637 ++++ + +E+ + N L+EL+ Q+I++ + + + E ++ + ET Sbjct: 1939 QEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQET 1998 Query: 638 TELMKEK--------EILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQ 689 +LMKEK ++ D L +++ LE ++ + ++ ++ E+EK L +L +Q Sbjct: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRF---IELEQEKNTELMDL-RQQ 2054 Query: 690 KTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL----------EHESRLDE- 738 L+ E MR+ L +Q DV + + LE QQL EH++R E Sbjct: 2055 NQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE-QQLKVVPRFQPISEHQTREVEQ 2113 Query: 739 ------EKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ-AQREQDHF----V 787 EK + +LL + QR+I R E+I L+ + + Q ++ HF Sbjct: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEA 2173 Query: 788 KEKNNLIMMLQREKENLCNLEKKYSSL 814 K + +L + LQ E++ + EK+ ++L Sbjct: 2174 KPELSLEVQLQAERDAIDRKEKEITNL 2200 Score = 57.4 bits (137), Expect = 8e-08 Identities = 114/571 (19%), Positives = 230/571 (40%), Gaps = 91/571 (15%) Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDE-SFRELDMECALLDGEQK----- 634 EQ + L + +L + E+L++ I++ N+++++ FR ++E ALL ++K Sbjct: 2112 EQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAV 2171 Query: 635 ------SETTELMKEKEILDHLNRKIAELEKNI------VGEKTKEKVKLDAE-----RE 677 S +L E++ +D ++I LE+ + + K +E +L + +E Sbjct: 2172 EAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKE 2231 Query: 678 KLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHES--- 734 RLQEL E K D+ E+L +K ++D + + +H +F Q+ E Sbjct: 2232 STTRLQELEQENKLFKDDM-----EKLGLAIK-ESDAMSTQDQHVLFGKFAQIIQEKEVE 2285 Query: 735 --RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ---REQDHFVKE 789 +L+E+ L QQL ++ + I + E I L+ Q ++ + R ++ +++ Sbjct: 2286 IDQLNEQVTKLQQQL--KITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2343 Query: 790 KNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISV-NEINEPCGNSTNLS 848 N +I LQ+E N+ G+ +N ++L E S+ ++++ L Sbjct: 2344 LNEVIEKLQQELANI------------GQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2391 Query: 849 PSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSI 908 + + Q + SL K+ +E + ++P +I Sbjct: 2392 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSL----KRERESVEKIQSIPENSVNVAI 2447 Query: 909 SPHFS----------SATMGRSITPKAHLPLGQSNSCGSV-------LPPSLAAMAKDSE 951 H S + +S+ + + + N GS+ L AKD E Sbjct: 2448 D-HLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLE 2506 Query: 952 SR---RMLRGYNHQQMSEGHRQKSEFYN---------RTASESNVYLNSFHYPDHSYKDQ 999 + ++ Q E + + N A S + L + +++ Q Sbjct: 2507 LTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQ--EYAKFCQ 2564 Query: 1000 AFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESRERE 1059 T+S + + +++ D + S ++ RI E+E + + H T L+ +E+ Sbjct: 2565 DNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMH---TSLILEKEQV 2621 Query: 1060 MEAKKRALEEEKRRREILEKRLQEETSQRQK 1090 A+K LE+EK+ E+ + E QR+K Sbjct: 2622 EIAEKNVLEKEKKLLELQKLLEGNEKKQREK 2652 Score = 54.3 bits (129), Expect = 7e-07 Identities = 125/600 (20%), Positives = 240/600 (40%), Gaps = 107/600 (17%) Query: 394 DLESLRQAS--GTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 451 +LE+L+Q S G + R SS + +G ++ + E+ +E+E++R Sbjct: 1659 ELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVE----EQTFKEKELDRKPEDVPP 1714 Query: 452 TILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRK 511 ILS + R + + KI E+ K + EE++ L D + Sbjct: 1715 EILS--------NERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSS 1766 Query: 512 DSL-----PDADLASCGS------LSQSSASFFTPRSTRND------------ELLSDLT 548 SL +A + SC +S S+ RND EL L Sbjct: 1767 ASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLV 1826 Query: 549 R-----TPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIV------- 596 R T P + + S + + K E ISE E A + +T ++ Sbjct: 1827 RSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQK 1886 Query: 597 -----ILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETT---ELMKEKEILD 648 L EEL++++ + + ++ EL ++DG +T ++ ++ +I+D Sbjct: 1887 QEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIID 1946 Query: 649 HLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYS------------------EQK 690 L +++ N + E E+ ++ ERE L R +E ++K Sbjct: 1947 RLEQELL-CASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEK 2005 Query: 691 TQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKEN--LTQQL- 747 ++ E +R+ LQ+Q+K A +DVE + +E +Q ++ +D ++N L +QL Sbjct: 2006 LEVQCQAEKVRDDLQKQVK--ALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLE 2063 Query: 748 -----LREVA---EYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQR 799 L E A E++R++ +++I L++Q +V + Q +H +E L L + Sbjct: 2064 KMRKFLDEQAIDREHERDVF--QQEIQKLEQQLK-VVPRFQPISEHQTREVEQLANHL-K 2119 Query: 800 EKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINE-----------PCGNSTNLS 848 EK + C+ E S + +++ V E+ + LS Sbjct: 2120 EKTDKCS-ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELS 2178 Query: 849 PSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSI 908 Q A+ DA+ + + + + E FR E K + + L++ + +K++T+ + Sbjct: 2179 LEVQLQAERDAI--DRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 2236 Score = 51.6 bits (122), Expect = 5e-06 Identities = 101/498 (20%), Positives = 202/498 (40%), Gaps = 95/498 (19%) Query: 390 FDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLER 447 + + + S++Q S +P L ERK+ I++IS DL+ + QRE + + Q E Sbjct: 2957 YSDGEDHSIQQVS---EPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSD 3013 Query: 448 QRLETILSLCAEYTKPDSRL---------STGTT-------------VEDVQKINKELEK 485 R E +L+L + + S L + GTT E + +E Sbjct: 3014 WRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMEC 3073 Query: 486 LQLSDEESVFEE------ALMSPDTRYRCHRKDSLPDADLASCGSLSQSS--------AS 531 LQ +D S+ E + + ++ P +L + S S Sbjct: 3074 LQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3133 Query: 532 FFTPRSTRND-----------ELLSDLTRTPPPPSSTFPKASS-----ESSYLSILPKTP 575 R+T EL S+L +T +T E+ L + KT Sbjct: 3134 SMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTD 3193 Query: 576 EG-------ISEEQRSQELA-AMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECA 627 E SE+++S+EL A+E+ + + + E K++++D+ + ES ++ +++ Sbjct: 3194 EVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSL-ESQKQRNLQLN 3252 Query: 628 LL---------DGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVK-----LD 673 LL + +QK E+ ++ + ++ + R LE ++ E K +++ LD Sbjct: 3253 LLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGR---NLELQVLLESEKVRIREMSSTLD 3309 Query: 674 AEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHE 733 ERE +LQ +++ E + ++LQ+QL E KH +E + Sbjct: 3310 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL---------EEKHSRIVELLNETEK 3360 Query: 734 SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNL 793 +LD + T+Q + + + R + +++ + ++ H +Q + ++EK Sbjct: 3361 YKLDSLQ---TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3417 Query: 794 IMMLQREKENLCNLEKKY 811 + L E + L + +++ Sbjct: 3418 VYKLDLEGQRLQGIMQEF 3435 Score = 50.8 bits (120), Expect = 8e-06 Identities = 89/438 (20%), Positives = 180/438 (41%), Gaps = 59/438 (13%) Query: 398 LRQASGTPQPALRERKSSISSISGRDDLMDYHRRQ---REERLREQEMERLERQRLETIL 454 L +A G E+ I + D++D ++ RL+E E E+ + Q +L Sbjct: 1917 LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL 1976 Query: 455 SLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 514 S E K ++ +++ +K+ KE ++Q E+ +D L Sbjct: 1977 SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKV-----------------RDDL 2019 Query: 515 PDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKT 574 A + + + F +N EL+ DL + K +I + Sbjct: 2020 QKQVKALEIDVEEQVSRFIELEQEKNTELM-DLRQQNQALEKQLEKMRKFLDEQAIDREH 2078 Query: 575 PEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQK 634 + + QE+ +E+ V+ + + +++ +Q+ +E +C+ L ++ Sbjct: 2079 ERDVFQ----QEIQKLEQQLKVVPRFQPISEHQTREV-EQLANHLKEKTDKCSELLLSKE 2133 Query: 635 SETTELMKEKEILDHLNRKIAELEKNIVGEKTKE------------KVKLDAEREKLERL 682 ++ + E ++ L ++ ELE+ ++ E K +V+L AER+ ++R Sbjct: 2134 QLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK 2193 Query: 683 QELYSEQKTQLDNCPESMREQLQQQLKRDADL---LDVESKHFEDLEFQQLEHESRL--- 736 + ++ T L+ E RE+L+ + + L L+++ K Q+LE E++L Sbjct: 2194 E----KEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKE-STTRLQELEQENKLFKD 2248 Query: 737 DEEKENL---------TQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDH-F 786 D EK L TQ ++ + I ++ +I L +Q + QQ + D+ Sbjct: 2249 DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKV 2308 Query: 787 VKEKNNLIMMLQREKENL 804 ++EKN LI L+ + E L Sbjct: 2309 IEEKNELIRDLETQIECL 2326 Score = 50.4 bits (119), Expect = 1e-05 Identities = 80/453 (17%), Positives = 196/453 (43%), Gaps = 51/453 (11%) Query: 388 VEFDEADLESLRQASGTPQPALRERKSSISSISG-RDDLMDYHRRQREERLREQ------ 440 + F ++ RQ + L E S+S++ + +++ ++E L+ + Sbjct: 537 LSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNY 596 Query: 441 --EMERLERQRLETILSLCAEYTKPD-SRLSTGTTVEDVQKINKELEKLQLSDEESVFEE 497 ++E LE+++ +L AE + + RL T ++++K E L++ ++ E+ Sbjct: 597 KIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINI-EK 654 Query: 498 ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSST 557 + Y+ + D L + ++ + T + ++L+ ++++ S Sbjct: 655 LKDNLGIHYK-QQIDGLQNEMSQKIETMQFEKDNLIT----KQNQLILEISKLKDLQQSL 709 Query: 558 FPKASSESSY-LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMD 616 S E + ++ L K E + +E++ + E + + L L++++K+ + + Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL--LEKQMKEKENDLQ 767 Query: 617 ESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAER 676 E F +L+ E ++L E+K+ +++K ++ +++ E+ I + K K K Sbjct: 768 EKFAQLEAENSILKDEKKT-LEDMLK-------IHTPVSQEERLIFLDSIKSKSKDSVWE 819 Query: 677 EKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHE-SR 735 +++E L E + K Q QL +++++ + K+FE + +Q+L+ E + Sbjct: 820 KEIEILIEENEDLKQQC--------IQLNEEIEKQRNTFSFAEKNFE-VNYQELQEEYAC 870 Query: 736 LDEEKENLTQQLLREVAEYQRNIVSRKEKI-------------SALKKQANHIVQQAQRE 782 L + K++L ++ EY+ + + E++ S++ + V + Sbjct: 871 LLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEM 930 Query: 783 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS 815 + K+ L+ L+ K L ++ S LS Sbjct: 931 GEVVEKDTTELMEKLEVTKREKLELSQRLSDLS 963 Score = 46.6 bits (109), Expect = 1e-04 Identities = 100/565 (17%), Positives = 220/565 (38%), Gaps = 70/565 (12%) Query: 555 SSTFPKASSESSYLSILPKT--PEGISEEQR-------SQELAAMEETRIVILNN-LEEL 604 S+T SSE + S + +T P + E+ S++ A T + ++ + L Sbjct: 108 STTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGK 167 Query: 605 KQKIKDINDQMDE-----------SFRELDMECALLDGEQKSETTELMKEKEILDHLNRK 653 + +I+++N +++E +E + DG T L + + D R+ Sbjct: 168 QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMRE 227 Query: 654 IAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQL---QQQLKR 710 EL T++ KL + ++L+ + L + + ++Q+ QQQL+ Sbjct: 228 FLEL--------TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 279 Query: 711 DADLLDVESKHFEDLEFQ-----------QLEHESRLD-------EEKENLTQQLLREVA 752 LL+ K ED Q ++E + +++ +EKE + ++L ++ Sbjct: 280 QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKII 339 Query: 753 EYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYS 812 E ++ + K+K++ K + +Q ++ K L Q+E+++ +++ Sbjct: 340 EEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMG 399 Query: 813 SLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ 872 ++ + K+ + + Q A+ D + + V Q Sbjct: 400 TVE-----ELQKRNHKDSQFETDIVQRM--EQETQRKLEQLRAELDEMYGQ--QIVQMKQ 450 Query: 873 PQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQS 932 ++H +EE K +HK + ++ S+I+ + + + ++ L + Sbjct: 451 ELIRQHMAQMEEMKTRHK-----GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDT 505 Query: 933 NSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYP 992 NS L L + ++ + + +++S R++ + +T +E LN H Sbjct: 506 NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS-REQIQRARQTIAEQESKLNEAHKS 564 Query: 993 DHSYKDQAFDTLSL-DSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAE--- 1048 + +D + +S +S +E A + + ++R+ + AE Sbjct: 565 LSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELER 624 Query: 1049 -KTRLLESREREMEAKKRALEEEKR 1072 +T+LL S E E+ K LE E R Sbjct: 625 LRTQLLFSHEEELSKLKEDLEIEHR 649 Score = 42.4 bits (98), Expect = 0.003 Identities = 56/246 (22%), Positives = 110/246 (44%), Gaps = 53/246 (21%) Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640 +++ Q M + +IV L + E K ++ E+ +E C Q ++T Sbjct: 2518 QEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFC------QDNQTISS 2571 Query: 641 MKEKEILDHLNR---------------KIAELEKNIVGEKT-----KEKVKLDAEREKLE 680 E+ + +LN+ +I+ELE +V T KE+V++ AE+ LE Sbjct: 2572 EPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEI-AEKNVLE 2630 Query: 681 RLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV---------ESKHFEDLEFQQLE 731 + ++L QK L+ + RE+ +++ +D ++L ES F +LE + E Sbjct: 2631 KEKKLLELQKL-LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE 2689 Query: 732 HES-------------RLDEE---KENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI 775 + +L EE KE L +++++ + ++ KEK+S L+K+ Sbjct: 2690 SVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE 2749 Query: 776 VQQAQR 781 VQ++++ Sbjct: 2750 VQESKK 2755 Score = 41.6 bits (96), Expect = 0.005 Identities = 84/429 (19%), Positives = 161/429 (37%), Gaps = 106/429 (24%) Query: 431 RQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKL--QL 488 +Q E LR+ M ++ERQR ED +++ +E+++L QL Sbjct: 1602 QQATELLRQAHMRQMERQR------------------------EDQEQLQEEIKRLNRQL 1637 Query: 489 SDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASFFTPRSTRNDELL 544 + S+ E L+S R ++L LA C L SS T N + Sbjct: 1638 AQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ--TQNGNENQGEV 1695 Query: 545 SDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEEL 604 + TF + L + PE + E S E A+++ +L L E+ Sbjct: 1696 EE---------QTFKEKE--------LDRKPEDVPPEILSNERYALQKANNRLLKILLEV 1738 Query: 605 KQKIKDINDQ--------MDESFRELDMECALLDGEQKSETTELMKE-------KEILDH 649 + + + +D S + + E ++ + E + I + Sbjct: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798 Query: 650 LNRKIAELEKNIVGEKTKEKVKL--------------DAEREKL------------ERLQ 683 + + N+ + T+E +L D E E+L E+L Sbjct: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLL 1858 Query: 684 ELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEE---- 739 E SE +QL++ + E +++ ++ + ES ++ ++L ESR E+ Sbjct: 1859 EAISETSSQLEHAKVTQTELMRESFRQKQEA--TESLKCQEELRERLHEESRAREQLAVE 1916 Query: 740 ---KENLTQQLLREVAEYQRNIVSRKEKISALKKQ---ANHIVQQAQREQDHFVKEKNNL 793 E + E ++R I + + I L+++ A++ +Q+ + EQ +E+ Sbjct: 1917 LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE-- 1974 Query: 794 IMMLQREKE 802 +L R+KE Sbjct: 1975 --LLSRQKE 1981 Score = 40.8 bits (94), Expect = 0.008 Identities = 75/349 (21%), Positives = 140/349 (40%), Gaps = 45/349 (12%) Query: 474 EDVQKINKE--LEKLQLSDEESV-FEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSA 530 E QKI + L QLS+E+ E ++ + R S D + L S Sbjct: 3264 ESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3323 Query: 531 SFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS---QEL 587 + + +++LL +L + S + +E+ + E+ R + L Sbjct: 3324 TGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTL 3383 Query: 588 AAMEETRIVILNNLEELKQKIKDINDQMDESFRE---LDMECALLDG------EQKSETT 638 +E + EL+ K++D+ Q++E ++ LD+E L G +Q+ E Sbjct: 3384 QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3443 Query: 639 ELMKEKEIL-DHLNRKIA-----------ELEKNIVGEKTKEK-----VKLDAE----RE 677 E + + IL +LN L++ I GE TKE ++++ Sbjct: 3444 EKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGE-TKESNYAKLIEMNGGGTGCNH 3502 Query: 678 KLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK------HFEDLEFQQLE 731 +LE +++ ++L P+ E+LQ + D D + V+ + L QQ E Sbjct: 3503 ELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGE 3562 Query: 732 HESRLDEEKE--NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ 778 S + +LT++LLR+ AE +I E+ + L+ + +Q Sbjct: 3563 EPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3611 Score = 40.0 bits (92), Expect = 0.014 Identities = 111/495 (22%), Positives = 198/495 (40%), Gaps = 87/495 (17%) Query: 365 SHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS---SISG 421 S LL+ E + RN +EF +LE E K +S + Sbjct: 2126 SELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQA 2185 Query: 422 RDDLMDYHRRQRE----ERLREQEMERLERQRLETI-LSLCAEYTKPDSRLSTGTTVEDV 476 D +D R+++E E EQ E LE + E L + E K +S T ++++ Sbjct: 2186 ERDAID--RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKEST----TRLQEL 2239 Query: 477 QKINK----ELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASF 532 ++ NK ++EKL L+ +ES +A+ + D L A Sbjct: 2240 EQENKLFKDDMEKLGLAIKES---DAMSTQDQHV------------------LFGKFAQI 2278 Query: 533 FTPRSTRNDELLSDLTRTPPPPSSTFPKASSE--SSYLSILPKTPEGISEEQ------RS 584 + D+L +T+ T E + + L E + +Q R Sbjct: 2279 IQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNRE 2338 Query: 585 QELAAMEETRIVILNNLEELKQKIK----DINDQMDESFRELDMECA-LLDGEQKSETT- 638 +E+ + E + L + QK ++++ D +LD+ A L EQ+ ET Sbjct: 2339 EEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETAN 2398 Query: 639 -ELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP 697 E+ K +L N K+ +L T+E L ERE +E++Q + + Sbjct: 2399 EEMTFMKNVLKETNFKMNQL--------TQELFSLKRERESVEKIQSIPENSVNVAIDHL 2450 Query: 698 ESMREQLQQQLKRDADLLDVES----KHFED--------LEFQQLEHESRLDEEKENLTQ 745 + +L+ L DA L +E+ K FE+ LE + L+ ES + + LTQ Sbjct: 2451 SKDKPELEVVLTEDA-LKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2509 Query: 746 -----QLLREVAEYQRNIVSRK----EKISALKKQANHIVQQAQRE--QDHFVKEKNNLI 794 + ++E +++ ++ +K +KI +K A +V Q Q E Q++ ++N Sbjct: 2510 CYKQIKDMQEQGQFETEMLQKKIVNLQKI-VEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2568 Query: 795 MMLQREKENLCNLEK 809 + + E+ N+ NL + Sbjct: 2569 ISSEPERTNIQNLNQ 2583 Score = 39.3 bits (90), Expect = 0.024 Identities = 97/488 (19%), Positives = 190/488 (38%), Gaps = 69/488 (14%) Query: 363 NPSH-----SLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS 417 +P+H S LAG+ + R V + L+ L++ + A+++R I+ Sbjct: 153 SPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEF----EAAIKQRDGIIT 208 Query: 418 SISGRDDLMDYHRRQREERLRE---------------QEMERLERQRLETILSLCAEYTK 462 ++ + RR+++E +RE Q+++ E R T S A+ + Sbjct: 209 QLTAN---LQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQ 265 Query: 463 PDSRLSTGTT--------VEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 514 ++ T +ED QK KE +Q+S + + M D + K+ + Sbjct: 266 AKQQILTHQQQLEEQDHLLEDYQK-KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 324 Query: 515 PDAD-----LASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLS 569 + + L + + + T D+LL +L + E + Sbjct: 325 QEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTN-- 382 Query: 570 ILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALL 629 K E S E+ Q + +EE + N ++ + + + E+ R+L+ A L Sbjct: 383 --SKQKERQSSEEIKQLMGTVEELQ---KRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437 Query: 630 DGEQKSETTELMKEKEILDHL-------NRKIAELEK------NIVGEKTKEKVKLDAER 676 D E + MK++ I H+ R E+E NI + + K+ A Sbjct: 438 D-EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN 496 Query: 677 EKLERLQELYSEQKTQLDNCPESMREQ--LQQQLKRDADLLDVESKHFEDLEFQQLEHES 734 E +LQ+ S+++ + + E+ LQ+QL+ + L + + E ES Sbjct: 497 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQES 556 Query: 735 RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLI 794 +L+E ++L+ V + + IVS E L+ + V + + + KEKN ++ Sbjct: 557 KLNEAHKSLST-----VEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611 Query: 795 MMLQREKE 802 + +E Sbjct: 612 DRMAESQE 619 Score = 38.5 bits (88), Expect = 0.041 Identities = 100/540 (18%), Positives = 212/540 (39%), Gaps = 72/540 (13%) Query: 603 ELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN-I 661 + K++ K ++ ++ E +E+ + S+ ++ + K+ + ++ ++ +K I Sbjct: 1509 KFKEEFKPLSKELGEHGKEILLS--------NSDPHDIPESKDCVLTISEEMFSKDKTFI 1560 Query: 662 VGEKTKEKVK---LDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV- 717 V + +++ +DA R+ + ++L E MR++L +Q + ++ Sbjct: 1561 VRQSIHDEISVSSMDASRQLMLNEEQL------------EDMRQELVRQYQEHQQATELL 1608 Query: 718 ESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ 777 H +E +Q E + +L EE + L +QL + + N+VS +E++ + +A + Sbjct: 1609 RQAHMRQME-RQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLS 1667 Query: 778 QAQREQDHFVKEKNNLIMMLQREKENLCNLEK---KYSSLSGGKGFPVNPNTLKEGYISV 834 A RE+ E N Q EN +E+ K L K V P L ++ Sbjct: 1668 LAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELD-RKPEDVPPEILSNERYAL 1724 Query: 835 NEINE------------PCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSL 882 + N + D + + A+ + S+ ++ Sbjct: 1725 QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVH 1784 Query: 883 EERKKQHKEGL--YLSDTLPR----------KKTTSSISPHFSSATMGRSITPK-AHLPL 929 EE + E + Y +PR ++ T S G I P+ L L Sbjct: 1785 EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELML 1844 Query: 930 GQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSF 989 S+ + + L A+++ S + + M E RQK E A+ES Sbjct: 1845 NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQE-----ATESLKCQEEL 1899 Query: 990 HYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEK 1049 H + +A + L+++ S + D + T +I+E ++ + E Sbjct: 1900 RERLHE-ESRAREQLAVELSKAEGVI------DGYADEKTLFERQIQEKTDIIDRLEQE- 1951 Query: 1050 TRLLESREREMEAKKRALEEEKRRREILEKRLQEETS--QRQKLIEKEVKIRERQRAQAR 1107 +R +E+EA+++ ++EE+ ++ ++ E ++Q L E E ++E+ Q + Sbjct: 1952 LLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011 Score = 33.1 bits (74), Expect = 1.7 Identities = 32/154 (20%), Positives = 74/154 (48%), Gaps = 22/154 (14%) Query: 590 MEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDH 649 ++E +V N+ L++ + + D + E+ +L ++L+ E ++E E K+ + + Sbjct: 2707 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKL----SILEKEDETEVQE-SKKACMFEP 2761 Query: 650 LNRKIAELEKNIVGEKTKEKVKLDAEREKLERL-----------QELYSEQKTQLDNCPE 698 L K+++ + +T +K+ + + + L E SE+ T++ + Sbjct: 2762 LPIKLSKS----IASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFT 2817 Query: 699 SMREQLQQQLKRDADLLDVESKHFEDLEFQQLEH 732 E++Q+ A++LD+ES+H + E + EH Sbjct: 2818 EKIEKMQEL--HAAEILDMESRHISETETLKREH 2849 Score = 32.7 bits (73), Expect = 2.2 Identities = 80/406 (19%), Positives = 151/406 (37%), Gaps = 64/406 (15%) Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645 E+ +E +LN + E K+ + ++ + + + L GE+ L KE+ Sbjct: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEEN-----LPKEET 1302 Query: 646 ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLE-RLQELYSEQKTQLDNCPESMREQL 704 ++ ++ LE V K+K D E+ KLE ++QEL ES+ L Sbjct: 1303 EFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL------------ESLISSL 1350 Query: 705 QQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEK 764 QQQLK + E + ++L+ S ++ ++ QR + Sbjct: 1351 QQQLKETEQNYEAEIHCLQ----KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPG--- 1403 Query: 765 ISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE-----KENLCNL----------EK 809 S +KK + ++ + + VKE+ N++ +L+++ +E + + + Sbjct: 1404 -SCVKKNIDGTIEFS---GEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQT 1459 Query: 810 KYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVL 869 + S +SGG KE S + + C + + D T V Sbjct: 1460 ELSRISGG----------KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDV- 1508 Query: 870 ASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR-----KKTTSSISPHFSSATMGRSITPK 924 + KE F+ L + +H + + LS++ P K +IS S + Sbjct: 1509 ----KFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQS 1564 Query: 925 AHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQ 970 H + S+ S +D + + HQQ +E RQ Sbjct: 1565 IHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQ 1610 >gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo sapiens] Length = 1940 Score = 61.2 bits (147), Expect = 6e-09 Identities = 89/439 (20%), Positives = 182/439 (41%), Gaps = 65/439 (14%) Query: 474 EDVQKINKEL--EKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSAS 531 ED ++IN EL +K +L DE S ++ + + K+ +++ Sbjct: 928 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEK----------HATENKVK 977 Query: 532 FFTPRSTRNDELLSDLTRTPPPPSSTFPKA----SSESSYLSILPKTPEGISEEQRSQEL 587 T + DE ++ LTR +A +E ++ L KT + ++ E Sbjct: 978 NLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLES 1037 Query: 588 AAMEETRIVILNNLEELKQKIK--------------DINDQMDESFRELDMECALLDGEQ 633 + +E ++ + +LE K+K++ + Q+DE ++ D E L + Sbjct: 1038 SLEQEKKLRV--DLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKV 1095 Query: 634 KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQL 693 + E T ++ ++ + L +I ELE+ I E+ + E+++ + +EL E +L Sbjct: 1096 EDEQTLGLQFQKKIKELQARIEELEEEIEAERA---TRAKTEKQRSDYAREL-EELSERL 1151 Query: 694 DNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAE 753 + Q++ KR+A+ L + DLE L+HE+ + ++ + Sbjct: 1152 EEAGGVTSTQIELNKKREAEFLKLR----RDLEEATLQHEAMVAALRK-----------K 1196 Query: 754 YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSS 813 + ++ E+I L++ + Q+ ++E+ F E ++L ++ ++ NLEK + Sbjct: 1197 HADSVAELGEQIDNLQR----VKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRT 1252 Query: 814 LSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQP 873 L + L E EI T Q A + E ++++ Sbjct: 1253 LE---------DQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLS 1303 Query: 874 QSKEHF-RSLEERKKQHKE 891 +SK+ F + EE K+Q +E Sbjct: 1304 RSKQAFTQQTEELKRQLEE 1322 Score = 52.0 bits (123), Expect = 4e-06 Identities = 87/408 (21%), Positives = 182/408 (44%), Gaps = 52/408 (12%) Query: 433 REERLREQEMERLERQRLETILSLCAEY-TKPDSRLSTGTTVEDVQKINKEL-EKLQLSD 490 RE+ EQE + ++ L S A++ TK ++ T E++++ K+L ++LQ S+ Sbjct: 1345 REQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT--EELEEAKKKLAQRLQDSE 1402 Query: 491 E--ESVFEEALMSPDTRYRCHRK--DSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD 546 E E+V + T+ R + D + D + A+ S A+ + D++L++ Sbjct: 1403 EQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERAN------SLAAALDKKQRNFDKVLAE 1456 Query: 547 LTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQ 606 + + ES LS + EE A+++ V N + L+Q Sbjct: 1457 WKTKCEESQAELEASLKESRSLSTELFKLKNAYEE-------ALDQLETVKREN-KNLEQ 1508 Query: 607 KIKDINDQMDES---FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVG 663 +I D+ +Q+ E+ EL+ ++ E+ L + + L+H KI ++ + Sbjct: 1509 EIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQ 1568 Query: 664 EKTKEKVKLDAEREKLERLQELYSE----QKTQLDNCPESMREQLQQQLKRDADLLDVE- 718 K++ K+ + E++E+L+ Y ++ LD S E ++ + K + DL ++E Sbjct: 1569 VKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEI 1628 Query: 719 ------------SKHFEDLEFQQLEHESRLDEE---KENLTQQLLREVAEYQRNIVSRK- 762 KH ++ Q + + LD+ +E+L +QL + E + N++ + Sbjct: 1629 QLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQL--AIVERRANLLQAEV 1686 Query: 763 EKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810 E++ A +Q + A++E + + N + +L + +L + +KK Sbjct: 1687 EELRATLEQTERARKLAEQE----LLDSNERVQLLHTQNTSLIHTKKK 1730 Score = 48.9 bits (115), Expect = 3e-05 Identities = 104/536 (19%), Positives = 211/536 (39%), Gaps = 73/536 (13%) Query: 568 LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECA 627 L + ++ + E+R +L + + + E + ++IN ++ R+L+ EC+ Sbjct: 890 LQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECS 949 Query: 628 LLDGE-QKSETTELMKEKE------ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLE 680 L + E T EKE + +L +++ L++ I ++K +A ++ L+ Sbjct: 950 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALD 1009 Query: 681 RLQ------ELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHES 734 LQ ++ K++L+ E + L+Q+ K DL + K DL+ Q E Sbjct: 1010 DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQ-ESIL 1068 Query: 735 RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLI 794 L+ +K+ L ++L ++ EY + + S+ E L Q +++ Q + +E Sbjct: 1069 DLENDKQQLDERLKKKDFEYCQ-LQSKVEDEQTLGLQFQKKIKELQARIEELEEE----- 1122 Query: 795 MMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFP 854 ++ E+ EK+ S + L+E ++E E G T+ Sbjct: 1123 --IEAERATRAKTEKQRSDYA---------RELEE----LSERLEEAGGVTSTQIELNKK 1167 Query: 855 ADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSS 914 +A+ + R LEE QH+ + RKK S++ Sbjct: 1168 REAEFLKLR----------------RDLEEATLQHEAMV----AALRKKHADSVAELGEQ 1207 Query: 915 ATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEF 974 + + K + L S+ +++K + + Q+SE R K+E Sbjct: 1208 IDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEA-RGKNEE 1266 Query: 975 YNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIAR 1034 R+ SE + T + + S +E S S +S + + + Sbjct: 1267 IQRSLSELTT------------QKSRLQTEAGELSRQLEEKESIVS--QLSRSKQAFTQQ 1312 Query: 1035 IEEMERLLKQAHAEKTRL---LESREREMEAKKRALEEEKRRREILEKRLQEETSQ 1087 EE++R L++ + K L L+S + + + EEE+ + L++ L + S+ Sbjct: 1313 TEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE 1368 Score = 47.4 bits (111), Expect = 9e-05 Identities = 101/477 (21%), Positives = 184/477 (38%), Gaps = 69/477 (14%) Query: 396 ESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLE--RQRLETI 453 E ++ Q AL + S ++ + + R + E +++ +RL+ +++E + Sbjct: 1349 EEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAV 1408 Query: 454 LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQ--LSDEESVFEEALMSPDTRYRCHRK 511 + CA K RL VED+ + L L ++ F++ L T+ C Sbjct: 1409 NAKCASLEKTKQRLQG--EVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTK--CEES 1464 Query: 512 DSLPDADLASCGSLSQSSASFFTPRSTRNDEL-------------LSDLTRTPPPPSSTF 558 + +A L SLS D+L ++DLT T Sbjct: 1465 QAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTI 1524 Query: 559 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 618 + + + + EE AA+E IL EL Q +I+ ++ E Sbjct: 1525 HELEKSRKQIELEKADIQLALEEAE----AALEHEEAKILRIQLELTQVKSEIDRKIAEK 1580 Query: 619 FRELD------------MECALLDGEQKSETTELMKEKEI----------LDHLNRKIAE 656 E++ M+ AL D E +S + +K++ L H NR+ AE Sbjct: 1581 DEEIEQLKRNYQRTVETMQSAL-DAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAE 1639 Query: 657 LEKN---IVGEKTKEKVKLDAEREKLERLQE---LYSEQKTQLDNCPESMREQLQQQLKR 710 K+ + G+ ++ LD E L+E + + L E +R L+Q + Sbjct: 1640 TLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERA 1699 Query: 711 ----DADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQ--QLLREVAEYQRNIVSRKEK 764 + +LLD E ++ ++ S + +K+ T QL EV + R+ + +EK Sbjct: 1700 RKLAEQELLDSN----ERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEK 1755 Query: 765 ISALKKQANHIVQQAQREQD---HFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGK 818 A + ++ ++EQD H + K NL ++ + L E+ +L GGK Sbjct: 1756 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ--LALKGGK 1810 Score = 41.6 bits (96), Expect = 0.005 Identities = 39/184 (21%), Positives = 82/184 (44%), Gaps = 23/184 (12%) Query: 584 SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKE 643 ++EL ++T + + L+Q +KD+ ++DE+ E L Sbjct: 1767 AEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA-----------------EQLALKGG 1809 Query: 644 KEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNC--PESMR 701 K+ + L +I ELE + GE+ K + R+ R++EL + + N + + Sbjct: 1810 KKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLV 1869 Query: 702 EQLQ---QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI 758 ++LQ + KR A+ D E + +F++ +HE EE+ ++ + + ++ R+ Sbjct: 1870 DKLQVKVKSYKRQAEEAD-EQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDF 1928 Query: 759 VSRK 762 S + Sbjct: 1929 TSSR 1932 Score = 35.8 bits (81), Expect = 0.26 Identities = 80/377 (21%), Positives = 140/377 (37%), Gaps = 58/377 (15%) Query: 748 LREVAEYQRNIVSRKEKISALKKQ-ANHIVQQAQREQD--HFVKEKNNLIMMLQREKENL 804 L + AE ++ + + KE+ K + A ++ + E+ V+EKN+L + +Q E ENL Sbjct: 840 LLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENL 899 Query: 805 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEP 864 + E++ L K F + + E+ E + ++ A E Sbjct: 900 LDAEERCDQLIKAK-FQLE--------AKIKEVTERAEDEEEINAE----LTAKKRKLED 946 Query: 865 ATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPK 924 + L E + E++K E + T + S + + T + + Sbjct: 947 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLT----EELSGLDETIAKLTREKKALQE 1002 Query: 925 AHL-----------PLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSE 973 AH + N S L + + E + LR E +++K E Sbjct: 1003 AHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLR-----VDLERNKRKLE 1057 Query: 974 FYNRTASESNVYL-NSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNI 1032 + A ES + L N D K + F+ L S E ++ I Sbjct: 1058 GDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQ---- 1113 Query: 1033 ARIEEMERLLKQAHAEKTRLLESRE---REMEAKKRALEE------------EKRRREIL 1077 ARIEE+E ++ A + + + R RE+E LEE +KR E L Sbjct: 1114 ARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFL 1173 Query: 1078 EKR--LQEETSQRQKLI 1092 + R L+E T Q + ++ Sbjct: 1174 KLRRDLEEATLQHEAMV 1190 >gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sapiens] Length = 1843 Score = 61.2 bits (147), Expect = 6e-09 Identities = 151/727 (20%), Positives = 289/727 (39%), Gaps = 91/727 (12%) Query: 137 ERALRLSE-KPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISR 195 E+A+R+ + + S+Y R HD + +E K +L + + L D +R Sbjct: 317 EKAVRVDKLESEVSRYKER--LHDIEFYKARVEELKEDNQVL-LETKTMLEDQLEGTRAR 373 Query: 196 SGAASMPSSPKQARKMSIQDSLALQPKLTRHK--ELASENINLR-TRKYSSSSLSHMGAY 252 S K + D + ++ + R K EL EN+ L +K S H+G Sbjct: 374 SDKLHELEKENLQLKAKLHD-MEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGW- 431 Query: 253 SRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGAL 312 L ++ R +E LS P+ SLG+ + L + + L + Sbjct: 432 --ELEQISRTSE-----LSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484 Query: 313 PYKTSASE------GNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV------ 360 + +AS+ N +S + + + V K L + + + D + + + Sbjct: 485 SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544 Query: 361 ---GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS 417 + +L E++ + T + S EA ++ + + + +++E S +S Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604 Query: 418 SISG-----RDDLMDYHRRQREERLREQEMERLER-----QRLETILSLCAEYTKPDSRL 467 I + +L Y + E E+ LE+ Q+ T L + E + + Sbjct: 605 KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664 Query: 468 STGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYRCHRKDSLPDADLASCGSLS 526 ++ ++++ N++L+K S + F+ E+L +++ + + + C S+ Sbjct: 665 NS-----ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK 719 Query: 527 QSSASFFTPRSTRNDELLSD---LTRTPPPPSSTFPKASS-ESSYLSI------LPKTPE 576 + N EL S+ L + ++F K E SY + L KT E Sbjct: 720 MAQLQL------ENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE 773 Query: 577 GISE--EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQK 634 ++ +Q EL +E + NLEELK K + +Q+++ + L+ E + L+ ++K Sbjct: 774 NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL-EQLEKENKSLEQETSQLEKDKK 832 Query: 635 S---ETTELMKEKEI----LDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYS 687 E L ++ EI L+ N KI LEK KT K ++ +E RL+EL Sbjct: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE---NKTLSK-EIGIYKESCVRLKELEK 888 Query: 688 EQKTQLDNCP------ESMREQL------QQQLKRDADLLDVESKHFEDLEFQQLEHESR 735 E K + ++RE L QQ+ D + L E + + + L E Sbjct: 889 ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS 948 Query: 736 LDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIM 795 D+ + L + L + +++ ++EKI+AL+ + Q+ + K N Sbjct: 949 TDDSRYKLLESKLESTLK--KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1006 Query: 796 MLQREKE 802 + QR+ E Sbjct: 1007 LKQRQDE 1013 Score = 53.5 bits (127), Expect = 1e-06 Identities = 92/453 (20%), Positives = 176/453 (38%), Gaps = 54/453 (11%) Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREER--LREQEMERLERQR 449 +A + LRQ L + K + + ++ R Q+E L + R+ R Sbjct: 257 KAKIRRLRQELEEKTEQLLDCKQELEQME-----IELKRLQQENMNLLSDARSARMYRDE 311 Query: 450 LETILSLCAEYTKPDSRLST-GTTVEDVQKINKELEKLQLSDEESVFEEALMSPD----T 504 L+ + K +S +S + D++ +E+L+ D + + E M D T Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK-EDNQVLLETKTMLEDQLEGT 370 Query: 505 RYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKAS-- 562 R R + L +L L R + + ++T S Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430 Query: 563 ------SESSYLSILPKTPEGIS-EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQM 615 S +S LS P+ G E S L +E + +EEL+ + + Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA 490 Query: 616 DESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAE 675 + + ++ E L + + E+++EK+ L + L K+++ EK + + ++ Sbjct: 491 SKILK-MEKENQRLSKKVEILENEIVQEKQSLQNCQN----LSKDLMKEKAQLEKTIETL 545 Query: 676 REKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVE-------------SKHF 722 RE ER ++ ++ L+ S+R+ + Q+ +A + D+E S Sbjct: 546 RENSERQIKILEQENEHLNQTVSSLRQ--RSQISAEARVKDIEKENKILHESIKETSSKL 603 Query: 723 EDLEFQ------QLEH---ESRLDEEKENLTQQLLREVAEYQRNIVSRK---EKISALKK 770 +EF+ +LEH + EE EN L +E Q+ I + K EKI AL++ Sbjct: 604 SKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663 Query: 771 QANHIVQQAQREQDHFVKEKNNLIMMLQREKEN 803 + + + ++ ++ + KN + EKEN Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKEN 696 Score = 47.8 bits (112), Expect = 7e-05 Identities = 116/567 (20%), Positives = 226/567 (39%), Gaps = 56/567 (9%) Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQM-DESFRELDMECALLDGEQKSETTELMKEK 644 EL A+ E + +++L+ ++ +++ D F + +E D + ET +++++ Sbjct: 311 ELDALREKAV----RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 366 Query: 645 -EILDHLNRKIAELEKNIVGEKTK---EKVKLDAEREKLERLQELYSEQKTQLDNCPESM 700 E + K+ ELEK + K K +++ D +R+K+E L E E T +SM Sbjct: 367 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME---ENMTLEMAQKQSM 423 Query: 701 REQLQ-----QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQ 755 E L +Q+ R ++L + K E +L L E EN Q L + V E + Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGH-EVNELTSSRLLKLEMEN--QSLTKTVEELR 480 Query: 756 RNIVS---RKEKISALKKQANHIVQQAQREQDHFVKEKN------NLIMMLQREKENLCN 806 + S KI ++K+ + ++ + ++ V+EK NL L +EK Sbjct: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK---AQ 537 Query: 807 LEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPAT 866 LEK +L N+ ++ I E ++L +Q A+A E Sbjct: 538 LEKTIETL--------RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589 Query: 867 AVL-ASQPQSKEHFRSLEERKKQHKEGL-YLSDTLPRKKTTSSISPHFSSAT--MGRSIT 922 +L S ++ +E K+Q K+ L + + R + + H + + IT Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKIT 649 Query: 923 PKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASES 982 +C + + E+R++ + + + + E N E Sbjct: 650 -------NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE 702 Query: 983 NVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLL 1042 N+ L + L L++ + + AS R+E + L Sbjct: 703 NLELRR-NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL 761 Query: 1043 KQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQE--ETSQRQKLIEKEVKIRE 1100 + + LE+ ++++ + L++ + + L+K L+E +S+R + +EKE K E Sbjct: 762 DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLE 821 Query: 1101 RQRAQARPLTRYLPVRKEDFDLRSHVE 1127 ++ +Q + L KE+ LR E Sbjct: 822 QETSQLEKDKKQL--EKENKRLRQQAE 846 Score = 47.0 bits (110), Expect = 1e-04 Identities = 86/418 (20%), Positives = 180/418 (43%), Gaps = 80/418 (19%) Query: 432 QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINK---------- 481 +R+ ++ EQE E L +T+ SL + S++S V+D++K NK Sbjct: 550 ERQIKILEQENEHLN----QTVSSL-----RQRSQISAEARVKDIEKENKILHESIKETS 600 Query: 482 ------ELEKLQLSDEESVFEE----ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSAS 531 E EK Q+ E ++E A + + +++ L + + + + Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660 Query: 532 FFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQ-------RS 584 ++ S+L R T + + L L K + EE S Sbjct: 661 L--------EQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712 Query: 585 QELAAMEETRIVILNN-LEELKQKIKD----------INDQMDESFRELDMECALLDGEQ 633 + A+M+ ++ + N LE K+++K ++++ S++ LD+E L Sbjct: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772 Query: 634 KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAER-EKLERLQELYSEQKTQ 692 ++ ++ + + L L + L+KN+ E++K+ ++R E+LE+ + ++ +Q Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNL------EELKISSKRLEQLEKENKSLEQETSQ 826 Query: 693 LDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDE-EKENLTQQLLREV 751 L E ++QL+++ KR +++ E E+ ++ EKEN T L +E+ Sbjct: 827 L----EKDKKQLEKENKRLRQQAEIKDTTLE-------ENNVKIGNLEKENKT--LSKEI 873 Query: 752 AEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEK 809 Y+ + V KE L+K+ +V++A + V + +L+ + ++ +LEK Sbjct: 874 GIYKESCVRLKE----LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927 Score = 45.4 bits (106), Expect = 3e-04 Identities = 97/472 (20%), Positives = 195/472 (41%), Gaps = 49/472 (10%) Query: 372 ESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRR 431 E+ R+ T N S ++ E++L+ L + T Q L E K S + + Sbjct: 764 ENQRLQKTLEN-SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE---------QL 813 Query: 432 QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKI-NKELEKLQLSD 490 ++E + EQE +LE+ + + L + + + + T E+ KI N E E LS Sbjct: 814 EKENKSLEQETSQLEKDKKQ--LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871 Query: 491 EESVFEEALMSPDTRYRCHRKDSLPDA--DLASCGSLSQSSASFFTPRSTRNDELLSDLT 548 E +++E+ + + K+ + A D+ + +L + S N++L LT Sbjct: 872 EIGIYKESCVRLKELEK-ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL-EKLT 929 Query: 549 RTPPPPSST-----FPKASSESSYLSILPKTPEGI---SEEQRSQELAAMEETRIVILNN 600 + S++ S +L E S E + +++AA+E N Sbjct: 930 HELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY 989 Query: 601 LEELKQKIKDIN------------DQMDESFRELDMECALLDGEQKSETTELMKEKEILD 648 ++L+Q++K + ++M +S + E + E + T EL+K K+ L Sbjct: 990 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1049 Query: 649 HLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQL 708 + R A L+ KT+ K +L+ + L+ Q L +++ Q +L Sbjct: 1050 EVERNNATLQAEKQALKTQLK-QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ-NAKL 1107 Query: 709 KRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISAL 768 + + L+ +S + Q L +S L+ E E++ ++ ++ +++ EK+ L Sbjct: 1108 QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE-REDLKSLYDSLIKDHEKLELL 1166 Query: 769 -KKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKG 819 ++QA+ E + + + L + + +LE +Y+ L KG Sbjct: 1167 HERQAS--------EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKG 1210 Score = 40.0 bits (92), Expect = 0.014 Identities = 44/193 (22%), Positives = 94/193 (48%), Gaps = 17/193 (8%) Query: 585 QELAAMEETRIVILN-NLEELKQKIKDI---NDQMDESFRELDMECALLDGEQKSETTEL 640 +++ +E+ ++++ N N E + + K + ND+++ ++ +L E +L + K+ Sbjct: 1216 EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNL---- 1271 Query: 641 MKEKEILDHLNRKIAELEKNIVGEKTKEKVK-LDAEREKLERLQELYSEQKTQLDNCPES 699 K +L+ N K+ + K KE+ + LD KL EL S+ K L+ Sbjct: 1272 ---KSLLN--NSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1326 Query: 700 MREQLQQQLKRDADLLD--VESKHFEDLEFQQ-LEHESRLDEEKENLTQQLLREVAEYQR 756 + +Q+Q + ++ LL+ +ESK +E +Q ++ + L +KE L ++++ + Y Sbjct: 1327 LLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDP 1386 Query: 757 NIVSRKEKISALK 769 + R+ LK Sbjct: 1387 SPPRRRGNWITLK 1399 Score = 31.2 bits (69), Expect = 6.5 Identities = 43/224 (19%), Positives = 103/224 (45%), Gaps = 30/224 (13%) Query: 605 KQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGE 664 ++ +K + D + + +L+ LL Q SE L+ + L ++ + E+E + + Sbjct: 1146 REDLKSLYDSLIKDHEKLE----LLHERQASEYESLISKHGTLKSAHKNL-EVEHRDLED 1200 Query: 665 KTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFED 724 + + +K + E LE++ ++ E+ + E++ + ++ + L S+ ++ Sbjct: 1201 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1260 Query: 725 LEFQQLEHE--------SRLDEEKENLTQQLLREVAEYQR-NIVSRK-----EKISALK- 769 E Q +H+ S+L++ + L+E +YQ+ +I S K E +S LK Sbjct: 1261 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE--QYQQLDITSTKLNNQCELLSQLKG 1318 Query: 770 ---KQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810 ++ H++ Q Q + +N ++ E ++L ++E++ Sbjct: 1319 NLEEENRHLLDQIQT-----LMLQNRTLLEQNMESKDLFHVEQR 1357 >gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] Length = 1780 Score = 61.2 bits (147), Expect = 6e-09 Identities = 110/502 (21%), Positives = 204/502 (40%), Gaps = 81/502 (16%) Query: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480 G D L+ ++ +E R++E E +E I C E K S+ S ++++ Sbjct: 990 GNDYLVS--KQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKS-----HQIEELE 1042 Query: 481 KELEKLQ------------LSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528 +++EKLQ L ++E ++ L+ K+ L + ++ + Sbjct: 1043 QQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHV 1102 Query: 529 SASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELA 588 LS+LT+ T KA + + + E + Q++ Sbjct: 1103 ---------VEGKRALSELTQ-----GVTCYKAKIKELETILETQKVECSHSAKLEQDIL 1148 Query: 589 AMEETRIVILNNLEELKQKIKD-INDQMDESFRELDMECALLDGEQKSETTELMKEKEIL 647 E + + NL+E ++ ++D + + D + +EL + K E T+L + + Sbjct: 1149 EKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKL---------KEEITQLTNNLQDM 1199 Query: 648 DHLNRKIAELEKNIVGEKTKEKVKLDAE-------REKLERLQELYSEQKTQLDNCPESM 700 HL + E E+ E K K +L A + L+R +E Y++ K +L + + + Sbjct: 1200 KHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQI 1259 Query: 701 RE-QLQQQLKRDAD-LLDVESKHFEDLE---FQQLEHESR-LDEEKENLTQQLLRE-VAE 753 ++ Q + + RD D LL ++ E + Q+L+ + R + + KE L Q + E + + Sbjct: 1260 KQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQ 1319 Query: 754 YQR--NIVSRKEKISALKKQANHIVQQAQREQDHFVKEK----NNLIMMLQREKENLCNL 807 Y+R ++ KEKI + +Q Q EQD ++ K L L++ KE +L Sbjct: 1320 YERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDL 1379 Query: 808 EKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPA---DADAVATEP 864 E K + S K N + L G TNL Q +AD Sbjct: 1380 ETKNNQRS-NKEHENNTDVL--------------GKLTNLQDELQESEQKYNADRKKWLE 1424 Query: 865 ATAVLASQPQSKEHFRSLEERK 886 +L +Q + E+ R+ E +K Sbjct: 1425 EKMMLITQAKEAENIRNKEMKK 1446 Score = 37.4 bits (85), Expect = 0.091 Identities = 62/306 (20%), Positives = 125/306 (40%), Gaps = 49/306 (16%) Query: 559 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN------LEELKQKIKDIN 612 P A S ++S + SEE R +A +E+ R++ NN L ++ ++K+ Sbjct: 804 PPAKKGSIHVSSAITEDQKKSEEVRPN-IAEIEDIRVLQENNEGLRAFLLTIENELKNEK 862 Query: 613 DQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAEL--EKNIVGEKTKEKV 670 ++ E +++ L +K T + ++I + + IAEL +K+ E+ ++ + Sbjct: 863 EEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIM 922 Query: 671 KLDAERE------------------KLERLQELYSEQKTQLDNCPESMREQLQQQLKRD- 711 KL E E K++ L+ L + +Q+ N L + D Sbjct: 923 KLSNEIETATRSITNNVSQIKLMHTKIDELRTL--DSVSQISNIDLLNLRDLSNGSEEDN 980 Query: 712 -----ADLLDVE---SKHFEDLEFQQLEHESRLDEEKENLTQQLLR----------EVAE 753 DLL + SK ++ Q+ E+ E + ++ ++ E Sbjct: 981 LPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEE 1040 Query: 754 YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE-KENLCNLEKKYS 812 ++ I + ++ K + N + ++ + QD +KEK LI L+ E +E L+ + Sbjct: 1041 LEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQ 1100 Query: 813 SLSGGK 818 + GK Sbjct: 1101 HVVEGK 1106 Score = 32.0 bits (71), Expect = 3.8 Identities = 21/88 (23%), Positives = 45/88 (51%), Gaps = 5/88 (5%) Query: 1035 IEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--REILEKRLQEETSQRQKLI 1092 +EE+E + + E L E ++ +E K + E++R +++E ++ +++++ + Sbjct: 536 VEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKL 595 Query: 1093 EKEVKIRERQRAQARPLTRYLPVRKEDF 1120 E KIRE + T+Y R+ DF Sbjct: 596 TLEFKIREE---VTQEFTQYWAQREADF 620 >gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo sapiens] Length = 1983 Score = 60.5 bits (145), Expect = 1e-08 Identities = 101/452 (22%), Positives = 195/452 (43%), Gaps = 58/452 (12%) Query: 392 EADLESLRQASGTPQPALRERKSSISSISGR-DDLMDYHRRQREE-RLREQEMERLERQR 449 E +LE+ R A + E + +S R ++ QRE R RE E+ RL R+ Sbjct: 1168 EEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRREL 1227 Query: 450 LETILSLCAEYT-----KPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDT 504 E L A + + G V+ +Q++ ++LEK E+S E M D Sbjct: 1228 EEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEK-----EKS---ELRMEVD- 1278 Query: 505 RYRCHRKDSLPDADLAS-CGSLSQSSASFFTPRSTRNDEL------LSDLTRTPPPPSST 557 DLA+ +L+++ AS T D+L + +L R S+ Sbjct: 1279 -------------DLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQ 1325 Query: 558 FPKASSESSYLSILPKTPEG-ISEEQRSQELAAMEETRIVILNNLEELKQKIKD---IND 613 + +ES LS L + E IS+ R + LAA +LEEL++++++ Sbjct: 1326 RGRLQTESGELSRLLEEKECLISQLSRGKALAAQ---------SLEELRRQLEEESKAKS 1376 Query: 614 QMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLD 673 + + + L +C LL + + E + + +L N ++A+ + + +L+ Sbjct: 1377 ALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELE 1436 Query: 674 AEREKLE-RLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEF---QQ 729 ++KL RLQE +E+ + N S E+ + +L+ +++ + +E + ++ Sbjct: 1437 EAKKKLALRLQE--AEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKK 1494 Query: 730 LEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALK---KQANHIVQQAQREQDHF 786 H R EE+ +++ RE+ QR ++ L+ ++A ++ +RE + Sbjct: 1495 QRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNL 1554 Query: 787 VKEKNNLIMMLQREKENLCNLEKKYSSLSGGK 818 +E ++L + +++ LEK +L G K Sbjct: 1555 QEEISDLTDQVSLSGKSIQELEKTKKALEGEK 1586 Score = 47.4 bits (111), Expect = 9e-05 Identities = 164/785 (20%), Positives = 278/785 (35%), Gaps = 166/785 (21%) Query: 396 ESLRQASGTPQPALRERKSSISSISGR--DDLMDYHRRQREERLREQEMERLERQRLETI 453 E+ +QA G Q A +R S+++ R + D +E+ + ER +R +LE Sbjct: 1050 EAHQQALGDLQ-AEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKR-KLEGD 1107 Query: 454 LSLCAEYT---------------KPDSRLST-GTTVEDVQ----KINKELEKLQLSDEES 493 L L E K DS LS VED Q ++ K++++LQ EE Sbjct: 1108 LKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEEL 1167 Query: 494 VFE-EALMSPDTRYRCHRKDSLPDAD-----LASCGSLSQSSASFFTPRSTRNDELLSDL 547 E EA + R R ++ + + L G S R L +L Sbjct: 1168 EEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRREL 1227 Query: 548 TRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQK 607 E++ ++ K EG +E +++ +++ R + EL+ + Sbjct: 1228 EEAA---------LRHEATVAALRRKQAEGAAE--LGEQVDSLQRVRQKLEKEKSELRME 1276 Query: 608 IKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTK 667 + D+ ++ R A E+ T E + L K+ EL++ + T Sbjct: 1277 VDDLAANVETLTR------AKASAEKLCRTYE-----DQLSEAKIKVEELQRQLADAST- 1324 Query: 668 EKVKLDAEREKLERLQE-------LYSEQKTQLDNCPESMREQLQQQLKRDADLLDVES- 719 ++ +L E +L RL E S K E +R QL+++ K + L Sbjct: 1325 QRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQA 1384 Query: 720 -KHFEDLEFQQLEHESRLDEEKENLTQQLLREVAE----YQRNIVSRKEKISALKKQANH 774 +H DL +Q E E+ E + L + EVA+ Y+ + + R E++ KK+ Sbjct: 1385 LRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKK--- 1441 Query: 775 IVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISV 834 L + LQ +E + K SSL K + T E Sbjct: 1442 ------------------LALRLQEAEEGVEAANAKCSSLEKAK---LRLQTESEDV--- 1477 Query: 835 NEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQ------ 888 + L +T A D A+ + Q +E R LE +++ Sbjct: 1478 ---------TLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGT 1528 Query: 889 --------HKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPL--------GQS 932 H+E L +TL K+ ++ S T S++ K+ L G+ Sbjct: 1529 ELFRLRHGHEEALEALETL--KRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEK 1586 Query: 933 NSCGSVLPPSLAAM--------------------------AKDSESRRMLRGYNHQQMSE 966 + + L + A+ KD E + R NHQ+ E Sbjct: 1587 SEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRR--NHQRAVE 1644 Query: 967 GHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISS 1026 + + R +E + D L L + T A + + Sbjct: 1645 SLQASLDAETRARNE------ALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQ 1698 Query: 1027 ASTSNIARIEEMERLLKQAHAEKTRLLESR----EREMEAKKRALEEEKRRREILEKRLQ 1082 R EE +RL + H E+ + LE R E+E + ALE+ +R R + E+ L Sbjct: 1699 LKEEQAGRDEE-QRLAAELH-EQAQALERRASLLAAELEELRAALEQGERSRRLAEQELL 1756 Query: 1083 EETSQ 1087 E T + Sbjct: 1757 EATER 1761 Score = 42.4 bits (98), Expect = 0.003 Identities = 105/467 (22%), Positives = 174/467 (37%), Gaps = 71/467 (15%) Query: 398 LRQASGTPQPALRERKSSISSISGRDDL----MDYHRRQREER----------------- 436 L+ SG L E++ IS +S L ++ RRQ EE Sbjct: 1329 LQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHD 1388 Query: 437 ---LREQEMERLERQ-RLETILSLC-AEYTKPDSRLSTGTT--VEDVQKINKELEKLQLS 489 LREQ E E Q L+ +LS AE + S+ E++++ K+L L+L Sbjct: 1389 CDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLA-LRLQ 1447 Query: 490 DEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTR 549 + E E A + + + D+ + S+A+ + + L + R Sbjct: 1448 EAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRR 1507 Query: 550 TPPPPSSTFPKASSESSYLSI-LPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKI 608 A ES L L + G E + E E NL+E + Sbjct: 1508 QEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKREN------KNLQEEISDL 1561 Query: 609 KDINDQMDESFRELDMECALLDGEQKSETTELMKEKE-ILDHLNRKIAELEKNIVGEKTK 667 D +S +EL+ L+GE KSE ++E E L+ K ++ + K + Sbjct: 1562 TDQVSLSGKSIQELEKTKKALEGE-KSEIQAALEEAEGALELEETKTLRIQLELSQVKAE 1620 Query: 668 EKVKLDAEREKLERL----QELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFE 723 KL + E+ L Q + LD + E L+ + K + DL D+E Sbjct: 1621 VDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLE----- 1675 Query: 724 DLEFQQLEHESRLDEEKENLTQ----QLLREVA---EYQRNIVSRKEKISALKKQANHIV 776 QL H +R E + T+ QL E A E QR E+ AL+++A+ + Sbjct: 1676 ----LQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLA 1731 Query: 777 -------------QQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810 ++++R + + E + +L + L N +KK Sbjct: 1732 AELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKK 1778 Score = 40.8 bits (94), Expect = 0.008 Identities = 38/172 (22%), Positives = 79/172 (45%), Gaps = 14/172 (8%) Query: 652 RKIAELEKNIVGEKTKEKVKLDAEREKLERLQE---LYSEQKTQLDNCPESMREQLQQQL 708 +++ E +I EK ++L AE++ L +E L + K QL+ + + E+L+ + Sbjct: 920 QELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEE 979 Query: 709 KRDADL------LDVE----SKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI 758 + +ADL L+ E K +DL+ + E + EN + L E+A ++ Sbjct: 980 EVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKE-KQATENKVKNLTEEMAALDESV 1038 Query: 759 VSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810 ++ AL++ + Q E+D + + Q+ ++ C+LE++ Sbjct: 1039 ARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQE 1090 Score = 39.3 bits (90), Expect = 0.024 Identities = 76/363 (20%), Positives = 141/363 (38%), Gaps = 45/363 (12%) Query: 372 ESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRR 431 E D A R +VE +A L++ +A ALR +K ++ + + + R Sbjct: 1627 EKDEECANLRRNHQRAVESLQASLDAETRARNE---ALRLKKKMEGDLNDLELQLGHATR 1683 Query: 432 QREE----------RLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINK 481 Q E +L+E++ R E QRL L A+ + + L +E+++ + Sbjct: 1684 QATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASL-LAAELEELRAALE 1742 Query: 482 ELEKLQLSDEESVFEEA----LMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRS 537 + E+ + E+ + E L+ ++K L +ADLA + +A Sbjct: 1743 QGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKL-EADLAQLSGEVEEAAQERREAE 1801 Query: 538 TRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVI 597 + + ++D + K S++L + KT E E + A +EE Sbjct: 1802 EKAKKAITDAAMM----AEELKKEQDTSAHLERMKKTLEQTVRELQ----ARLEEAEQAA 1853 Query: 598 LNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAEL 657 L ++ QK+ + REL+ E LD EQK L K + H R Sbjct: 1854 LRGGKKQVQKL-------EAKVRELEAE---LDAEQKKHAEAL---KGVRKHERRV---- 1896 Query: 658 EKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV 717 K + + +++ L ++ +++LQ K Q + + L + K +L D Sbjct: 1897 -KELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDA 1955 Query: 718 ESK 720 E + Sbjct: 1956 EER 1958 Score = 33.1 bits (74), Expect = 1.7 Identities = 25/105 (23%), Positives = 57/105 (54%), Gaps = 8/105 (7%) Query: 1026 SASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRA---LEEEKRRREI---LEK 1079 +A ++AR+ + ++ L++AH + L++ E + A +A LE++ E EK Sbjct: 1032 AALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEK 1091 Query: 1080 RLQEETSQRQKLIEKEVKIRERQRAQARPLTRYL--PVRKEDFDL 1122 +L+ +T + ++ +E ++K+ + A A + L ++K+D +L Sbjct: 1092 KLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSEL 1136 >gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] Length = 1684 Score = 60.1 bits (144), Expect = 1e-08 Identities = 73/393 (18%), Positives = 167/393 (42%), Gaps = 26/393 (6%) Query: 431 RQREERLREQEMERLERQRLETILSLCAEYTKPD---SRLSTGTTVEDVQKINKELEKLQ 487 ++ EE++ E E E++ + L A K + SR T T E+++ + E ++L Sbjct: 947 KELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLS 1006 Query: 488 LSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDL 547 S + + + A + ++ D + + R RN L + Sbjct: 1007 ASMRDLI-QGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDL--TRQLRNSTLQCET 1063 Query: 548 TRTPPPPS-STFPKASSESSYLSI----LPKTPEGISEEQRSQELAAMEETR--IVILNN 600 + + S + L + + + + +E +++L ++ + +N Sbjct: 1064 INSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123 Query: 601 LEELKQKIKDINDQMDESFREL-----DMECALLDGEQKSETTELMKE-KEILDHLNRKI 654 LEEL+ +++ Q+ ++ +EL D + L + ++ LMKE + L + N KI Sbjct: 1124 LEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKI 1183 Query: 655 AELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADL 714 +LE+ I +K K++ L E L+ + Y E+ T++ +++L + + D Sbjct: 1184 EDLEQEIKIQKQKQET-LQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDH 1242 Query: 715 LDVESKHFEDLEFQQLEHE------SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISAL 768 L +++ +LE Q + E + + EK + + L ++QR + + +++++AL Sbjct: 1243 LILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTAL 1302 Query: 769 KKQANHIVQQAQREQDHFVKEKNNLIMMLQREK 801 +++ + F K + +L+++K Sbjct: 1303 QEECRAAKAEQATVTSEFESYKVRVHNVLKQQK 1335 Score = 54.3 bits (129), Expect = 7e-07 Identities = 76/304 (25%), Positives = 130/304 (42%), Gaps = 43/304 (14%) Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600 ++L+ D +P P + S L LPK + I ++ L ++R L Sbjct: 2 EDLVQDGVASPATPGTG-------KSKLETLPKE-DLIKFAKKQMMLIQKAKSRCTELEK 53 Query: 601 -LEELKQK-----IKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKI 654 +EEL+ K DI + E L +E A + + S E +K K+ ++ K+ Sbjct: 54 EIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKM 113 Query: 655 AELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDN-CPESMREQLQ--QQLKRD 711 + K + +++ + +L ++ YSE K L E+M QL+ +QLK Sbjct: 114 GDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQ 173 Query: 712 ADLLDVESKHFEDLE-----------FQQLEHESRLDEEKENLTQQLLREVAE-----YQ 755 + D K E++E + Q + ++ DE+KE +TQ L+ + E YQ Sbjct: 174 NNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQ--LQNIIEANSQHYQ 231 Query: 756 RNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLC--------NL 807 +NI S +E++ LK V++ + + KE I L KENL N+ Sbjct: 232 KNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNI 291 Query: 808 EKKY 811 +KKY Sbjct: 292 QKKY 295 Score = 50.8 bits (120), Expect = 8e-06 Identities = 159/803 (19%), Positives = 306/803 (38%), Gaps = 178/803 (22%) Query: 426 MDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEK 485 ++ H R+ + L+EQ + + ET LS DS T + ++Q + ++ E Sbjct: 419 VEQHNREVQS-LKEQHQKEISELN-ETFLS--------DSEKEKLTLMFEIQGLKEQCEN 468 Query: 486 LQLSDEESVFE-----------EALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFT 534 LQ +E++ + + +S+ + L Q + FT Sbjct: 469 LQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFT 528 Query: 535 PRST----------RNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS 584 + N++LLS P ++ YL +S QR Sbjct: 529 EKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYL---------LSLSQRD 579 Query: 585 QELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALL--------------- 629 L +E + ++ K+K+ +++MD ++ + E L+ Sbjct: 580 TMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNS 639 Query: 630 DGEQK-SETT----ELMKEKEILDH------LNRKIAELEKNIVGEKTK----EKVKLDA 674 + EQK +E T E +KEK+ D + K+ +K ++ + K E KL + Sbjct: 640 ELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSS 699 Query: 675 EREKLERLQELYSEQK---------TQLDNCPESMREQ---LQQQLKRD----------- 711 E+++L R E++ QK TQL+ + M E+ L + L+ + Sbjct: 700 EKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQL 759 Query: 712 -ADLLDVESKHFEDLEFQQL--------EHESRLDEEKENLTQQLLREVAEYQRNIVSRK 762 L ++ S+ ED E + + E ++++EEK NL Q +V E ++ I + Sbjct: 760 YGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQ 819 Query: 763 EKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCN--LEKKYSSLSGGKGF 820 E+ ++ +++ ++E+ KE + +Q EKE L + LE K ++ K Sbjct: 820 EESVVQCEELKSLLRDYEQEKVLLRKE----LEEIQSEKEALQSDLLEMKNAN---EKTR 872 Query: 821 PVNPNTLKEGYISVNEINEPCGNS--------------TNLSP----------STQFPAD 856 N N L I V E+++ C S NL P + Sbjct: 873 LENQNLL----IQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILL 928 Query: 857 ADAVATEPATA--VLASQPQSKEHFRSLEERKKQHKE---GLYLSDTLPRKKTTSSISPH 911 D++A P+ L+S + +E +LE+ K+ +E + L +K+ SS Sbjct: 929 KDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSS---- 984 Query: 912 FSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSES-RRMLRGYNHQ--QMSEGH 968 R T L S L S+ + + +ES + +L Y Q Q+ Sbjct: 985 -------RKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEK 1037 Query: 969 RQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSAS 1028 + + F +R + NS +T++ D+ D + + S + Sbjct: 1038 ERANNFEHRIEDLTRQLRNS---------TLQCETINSDNEDLLARIETLQSNAKLLEVQ 1088 Query: 1029 TSNIARIE-------EMERLLKQ----AHAEKTRLLESREREMEAKKRALEEEKRRREIL 1077 + R + E E+L K+ HA LE + +++ +K+ L++ + E++ Sbjct: 1089 ILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELV 1148 Query: 1078 EKRLQEETSQRQKLIEKEVKIRE 1100 +K Q+ T ++ + E ++E Sbjct: 1149 KKDAQQTTLMNMEIADYERLMKE 1171 Score = 35.0 bits (79), Expect = 0.45 Identities = 33/137 (24%), Positives = 58/137 (42%), Gaps = 4/137 (2%) Query: 959 YNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISA 1018 Y +Q+ +K E T ++ + NS HY + Q + L L + E Sbjct: 200 YLQKQLDATTDEKKETV--TQLQNIIEANSQHYQKNINSLQE-ELLQLKAIHQEEVKELM 256 Query: 1019 CSPDNISSASTSNIARIEEM-ERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREIL 1077 C + + + I ++ E+ E L+KQ A + + + E E+E ++A + +I Sbjct: 257 CQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQIC 316 Query: 1078 EKRLQEETSQRQKLIEK 1094 LQE T Q + EK Sbjct: 317 SILLQENTFVEQVVNEK 333 >gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 750 Score = 59.7 bits (143), Expect = 2e-08 Identities = 66/259 (25%), Positives = 125/259 (48%), Gaps = 28/259 (10%) Query: 576 EGISEEQRSQELAAM--EETRI----VILNNLEELKQKIKDINDQMDESFRELDMECALL 629 E I EE++ QE M +E +I I E++ ++ + I Q ++ +R+ E + Sbjct: 464 EKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQ---EEKIR 520 Query: 630 DGEQKSETTE--LMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYS 687 + E+K E + +++E + E EK EK E+ K + +K+ R +E Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIR 580 Query: 688 EQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLE-FQQLEHESRLDEEK----EN 742 EQ+ ++ E +REQ +++ +++ + E K E E Q+ E + R EEK E Sbjct: 581 EQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEE 640 Query: 743 LTQQLLREVAEYQRNIVSRKEKI----SALKKQANHIVQQAQ--REQDHFVKEKNNLIMM 796 +TQ+ ++ E + + ++EK+ + +Q I +Q + REQ+ ++E+ + M Sbjct: 641 MTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEM-MQ 699 Query: 797 LQREK-----ENLCNLEKK 810 Q EK E +C E+K Sbjct: 700 EQEEKMWEQEEKMCEQEEK 718 Score = 46.6 bits (109), Expect = 1e-04 Identities = 51/270 (18%), Positives = 119/270 (44%), Gaps = 33/270 (12%) Query: 574 TPEGISEEQRS--QELAAMEETRIVILNNLEELKQKIK---------DINDQMDESFREL 622 T E + E+ ++L +E + I N++ELK+K++ + + D +EL Sbjct: 215 TDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL 274 Query: 623 DMECALLDGE----------QKSETTELMKEKEILDHLNRKIAELEKNI---------VG 663 A L + + + ++ +++E + KI E E+ I Sbjct: 275 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE 334 Query: 664 EKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFE 723 EK + + ++ E+E+ R QE +K + E M + +++++R +++ + + Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 394 Query: 724 DLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQR-- 781 +LE + E E ++E++ ++ +RE + Q + +++Q I +Q ++ Sbjct: 395 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMW 454 Query: 782 EQDHFVKEKNNLIMMLQR-EKENLCNLEKK 810 Q+ + E+ + +R E+E + E+K Sbjct: 455 RQEEKIHEQEKIREEEKRQEQEEMWRQEEK 484 Score = 45.1 bits (105), Expect = 4e-04 Identities = 30/148 (20%), Positives = 75/148 (50%), Gaps = 5/148 (3%) Query: 602 EELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNI 661 EE +Q+ ++ + +E RE + + + + + + ++ +++E+ K+ E E+ + Sbjct: 597 EEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKM 656 Query: 662 VGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKH 721 +++ K+ + E + R +E EQ+ ++ E +REQ + +++ + + E K Sbjct: 657 C----EQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 712 Query: 722 FEDLEFQQLEHESRLDEEKENLTQQLLR 749 E E Q E E ++ ++E + +Q +R Sbjct: 713 CEQEEKMQ-EQEEKMRRQEEKMWEQEVR 739 Score = 43.5 bits (101), Expect = 0.001 Identities = 45/235 (19%), Positives = 107/235 (45%), Gaps = 21/235 (8%) Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELM 641 +R +E+ +E +I L ++KI++ ++ E + + E +++ + ++ Sbjct: 380 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE------KRQEQEAKMW 433 Query: 642 KEKEILDHLNRKIAELEKNIVGEKTK----EKVKLDAEREKLERL--QELYSEQKTQLDN 695 +++E + KI E EK + ++ K EK++ + +R++ E + QE ++ ++ Sbjct: 434 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWR 493 Query: 696 CPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQ 755 E M EQ ++ K++ + E K ++ E + R EEK ++ +RE E Sbjct: 494 QKEKMHEQEEKIRKQEEKVWRQEEK------IREQEEKIREQEEKMWRQEEKIREQEEMW 547 Query: 756 RNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810 R E+ +++ + Q+ ++E+ + R++E + E+K Sbjct: 548 REEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVW---RQEEKIREQEEK 599 Score = 41.2 bits (95), Expect = 0.006 Identities = 49/234 (20%), Positives = 102/234 (43%), Gaps = 46/234 (19%) Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELM 641 ++ +++ EE ++ EE ++ +++ + +E REL E+K E + Sbjct: 360 EKEEKMRRQEE----MMWEKEEKMRRQEEMMWEKEEKIREL---------EEKMHEQEKI 406 Query: 642 KEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMR 701 +E+E EK EK +E+ K + K+ R +E EQ+ E +R Sbjct: 407 REQE------------EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE-------EKIR 447 Query: 702 EQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSR 761 EQ ++ +++ + + E E E R ++E+ ++ + E E R Sbjct: 448 EQEKKMWRQEEKIHEQEKIR---------EEEKRQEQEEMWRQEEKIHEQEEIWRQKEKM 498 Query: 762 KEKISALKKQANHIVQQAQ--REQDHFVKEKNNLIMMLQ---REKENLCNLEKK 810 E+ ++KQ + +Q + REQ+ ++E+ + + RE+E + E+K Sbjct: 499 HEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEK 552 Score = 40.4 bits (93), Expect = 0.011 Identities = 36/151 (23%), Positives = 72/151 (47%), Gaps = 11/151 (7%) Query: 580 EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRE---LDMECALLDGEQKSE 636 EE+R ++ M + I E+++++ + I +Q +E RE + E GEQ+ + Sbjct: 597 EEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQ-EEKIREQEEMTQEQEEKMGEQEEK 655 Query: 637 TTE----LMKEKEILDHLNRKIAELEKNIVGEKTK---EKVKLDAEREKLERLQELYSEQ 689 E + +++E + KI E EK I ++ K ++ + + EK+ +E EQ Sbjct: 656 MCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 715 Query: 690 KTQLDNCPESMREQLQQQLKRDADLLDVESK 720 + ++ E MR Q ++ +++ L E K Sbjct: 716 EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746 Score = 35.8 bits (81), Expect = 0.26 Identities = 25/79 (31%), Positives = 43/79 (54%), Gaps = 7/79 (8%) Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREIL----EKRLQEETS---QR 1088 E+M R + ++ ++ E E+ E +K +EEKR+ E EKR ++E Q Sbjct: 377 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 436 Query: 1089 QKLIEKEVKIRERQRAQAR 1107 +K+ E+E KIRE+++ R Sbjct: 437 EKIREQEEKIREQEKKMWR 455 Score = 35.4 bits (80), Expect = 0.34 Identities = 25/82 (30%), Positives = 46/82 (56%), Gaps = 3/82 (3%) Query: 1024 ISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQ 1082 + S S A++EE E + ++ ++ E+ E +++ E+E++ RE EK R Q Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333 Query: 1083 EETSQRQK--LIEKEVKIRERQ 1102 EE +RQ+ + EKE K+R ++ Sbjct: 334 EEKMRRQEEMMWEKEEKMRRQE 355 Score = 35.0 bits (79), Expect = 0.45 Identities = 46/252 (18%), Positives = 103/252 (40%), Gaps = 26/252 (10%) Query: 653 KIAELEKNIVGE--KTKEKVKLDAEREKLERLQELYSEQKTQLDNC--PESMRE---QLQ 705 K+AE ++ + +T V A K +++ + + T C PE ++ Q Q Sbjct: 59 KLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQKASHQHQ 118 Query: 706 QQLKRDAD-------LLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI 758 + L+R+ + +L + + + +L+ E +L +L + ++ + Sbjct: 119 EALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL-HDSWKFAGEL 177 Query: 759 VSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGK 818 ++ KK+A+ +++ +E+D E + + KE L++K + K Sbjct: 178 EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEK 237 Query: 819 GFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATE--PATAVLASQPQSK 876 E ++V E+ + L P Q A+AD + E +A L +Q + Sbjct: 238 ---------SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 288 Query: 877 EHFRSLEERKKQ 888 E + L +++++ Sbjct: 289 ELWNRLNQQQEE 300 Score = 34.7 bits (78), Expect = 0.59 Identities = 26/71 (36%), Positives = 41/71 (57%), Gaps = 4/71 (5%) Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQ--KL 1091 +I+E E +++ EK R E +E E +K +EEK + + + QEET RQ K+ Sbjct: 620 KIQEQEEKIREQE-EKIREQEEMTQEQE-EKMGEQEEKMCEQEEKMQEQEETMWRQEEKI 677 Query: 1092 IEKEVKIRERQ 1102 E+E KIRE++ Sbjct: 678 REQEKKIREQE 688 Score = 33.9 bits (76), Expect = 1.0 Identities = 26/77 (33%), Positives = 41/77 (53%), Gaps = 9/77 (11%) Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEE------EKRRR--EILEKRLQEET 1085 +I+E E + Q EK R E + RE E K R EE EK RR E++ ++ ++ Sbjct: 308 KIQEWEEKI-QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366 Query: 1086 SQRQKLIEKEVKIRERQ 1102 Q + + EKE K+R ++ Sbjct: 367 RQEEMMWEKEEKMRRQE 383 Score = 33.9 bits (76), Expect = 1.0 Identities = 24/67 (35%), Positives = 40/67 (59%), Gaps = 8/67 (11%) Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKE 1095 E+ E++ +Q EK R E + +E E K EE+ R +E +++QE Q +K+ E+E Sbjct: 581 EQEEKVWRQE--EKIREQEEKRQEQEEKMWKQEEKIREQE---EKIQE---QEEKIREQE 632 Query: 1096 VKIRERQ 1102 KIRE++ Sbjct: 633 EKIREQE 639 Score = 33.5 bits (75), Expect = 1.3 Identities = 30/126 (23%), Positives = 59/126 (46%), Gaps = 26/126 (20%) Query: 577 GISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSE 636 G EE+ ++ M+E + E+++++ K I +Q +E RE + Sbjct: 650 GEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQ-EEKIREQE------------- 695 Query: 637 TTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNC 696 E+M+E+E K+ E E+ + +++ K+ + EK+ R +E EQ+ +L Sbjct: 696 --EMMQEQE------EKMWEQEEKMC----EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 743 Query: 697 PESMRE 702 E M+E Sbjct: 744 EEKMQE 749 Score = 33.1 bits (74), Expect = 1.7 Identities = 23/72 (31%), Positives = 40/72 (55%), Gaps = 3/72 (4%) Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIE 1093 +I E E K+ EK R E R+ E EAK EE+ R +E + +++ ++++ I Sbjct: 405 KIREQEE--KRQEEEKIREQEKRQ-EQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH 461 Query: 1094 KEVKIRERQRAQ 1105 ++ KIRE ++ Q Sbjct: 462 EQEKIREEEKRQ 473 Score = 33.1 bits (74), Expect = 1.7 Identities = 21/72 (29%), Positives = 45/72 (62%), Gaps = 6/72 (8%) Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQEETSQRQ--K 1090 +I E E+ +++ ++ ++ E E E +++ E+E++ E EK + QEE +RQ K Sbjct: 676 KIREQEKKIRE---QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 732 Query: 1091 LIEKEVKIRERQ 1102 + E+EV++R+++ Sbjct: 733 MWEQEVRLRQQE 744 Score = 32.7 bits (73), Expect = 2.2 Identities = 16/70 (22%), Positives = 43/70 (61%), Gaps = 2/70 (2%) Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK--RLQEETSQRQKLIE 1093 EE+ R ++ H ++ ++ + E+ +++ E+E++ RE EK R +E+ +++++ Sbjct: 489 EEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR 548 Query: 1094 KEVKIRERQR 1103 +E K+ E+++ Sbjct: 549 EEEKMHEQEK 558 Score = 32.3 bits (72), Expect = 2.9 Identities = 25/97 (25%), Positives = 49/97 (50%), Gaps = 6/97 (6%) Query: 1034 RIEEMERLLKQAHAEKTRLLES---REREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1090 +I E E +++ + R E +E+ E +KR +EE R+E +E Q++K Sbjct: 438 KIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEK 497 Query: 1091 LIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVE 1127 + E+E KIR+++ R + +R+++ +R E Sbjct: 498 MHEQEEKIRKQEEKVWRQEEK---IREQEEKIREQEE 531 Score = 32.3 bits (72), Expect = 2.9 Identities = 26/71 (36%), Positives = 40/71 (56%), Gaps = 5/71 (7%) Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQEETSQRQKLIEK 1094 E+ E++ KQ EK E + RE E K R EE+ R+E EK R QEE + ++ + + Sbjct: 500 EQEEKIRKQE--EKVWRQEEKIREQEEKIREQEEKMWRQE--EKIREQEEMWREEEKMHE 555 Query: 1095 EVKIRERQRAQ 1105 + KI E ++ Q Sbjct: 556 QEKIWEEEKRQ 566 Score = 32.3 bits (72), Expect = 2.9 Identities = 32/104 (30%), Positives = 51/104 (49%), Gaps = 16/104 (15%) Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQEETSQRQ--- 1089 +I E E +Q EK E + RE E K + EE+ R +E EK R QEE +Q Q Sbjct: 592 KIREQEEK-RQEQEEKMWKQEEKIREQEEKIQEQEEKIREQE--EKIREQEEMTQEQEEK 648 Query: 1090 ------KLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVE 1127 K+ E+E K++E++ R + +R+++ +R E Sbjct: 649 MGEQEEKMCEQEEKMQEQEETMWRQEEK---IREQEKKIREQEE 689 Score = 32.0 bits (71), Expect = 3.8 Identities = 21/76 (27%), Positives = 42/76 (55%), Gaps = 10/76 (13%) Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEK---------RRREILEKRLQEETS 1086 EEM R ++ H E+ ++ E +R+ + K +EEK R+ E + ++ ++ Sbjct: 544 EEMWREEEKMH-EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQE 602 Query: 1087 QRQKLIEKEVKIRERQ 1102 Q +K+ ++E KIRE++ Sbjct: 603 QEEKMWKQEEKIREQE 618 Score = 31.6 bits (70), Expect = 5.0 Identities = 26/75 (34%), Positives = 38/75 (50%), Gaps = 9/75 (12%) Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEE------EKRRR--EILEKRLQEET 1085 +I E E +++ EK R E E E K R EE EK RR E++ ++ ++ Sbjct: 322 KIREQEEKIREQE-EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 380 Query: 1086 SQRQKLIEKEVKIRE 1100 Q + + EKE KIRE Sbjct: 381 RQEEMMWEKEEKIRE 395 Score = 31.6 bits (70), Expect = 5.0 Identities = 23/64 (35%), Positives = 36/64 (56%), Gaps = 6/64 (9%) Query: 1048 EKTRLLESREREMEAKKRALEE-----EKRRREILEK-RLQEETSQRQKLIEKEVKIRER 1101 EK R E E E K R EE E++ RE+ EK QE+ ++++ ++E KIRE+ Sbjct: 363 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 422 Query: 1102 QRAQ 1105 ++ Q Sbjct: 423 EKRQ 426 Score = 31.2 bits (69), Expect = 6.5 Identities = 21/77 (27%), Positives = 42/77 (54%), Gaps = 3/77 (3%) Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQEETSQRQ--K 1090 +I E E++ ++ ++ + +E ++ ++ ++++ E EK R QEE RQ K Sbjct: 459 KIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEK 518 Query: 1091 LIEKEVKIRERQRAQAR 1107 + E+E KIRE++ R Sbjct: 519 IREQEEKIREQEEKMWR 535 Score = 30.8 bits (68), Expect = 8.5 Identities = 24/82 (29%), Positives = 42/82 (51%), Gaps = 14/82 (17%) Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQEETSQRQ----- 1089 E+ E++ +Q + ++ E E +++ E+EK+ RE EK R QEE Q Q Sbjct: 651 EQEEKMCEQ----EEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 706 Query: 1090 ----KLIEKEVKIRERQRAQAR 1107 K+ E+E K++E++ R Sbjct: 707 EQEEKMCEQEEKMQEQEEKMRR 728 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.310 0.126 0.347 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 48,573,611 Number of Sequences: 37866 Number of extensions: 2376058 Number of successful extensions: 24724 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 328 Number of HSP's successfully gapped in prelim test: 1108 Number of HSP's that attempted gapping in prelim test: 12257 Number of HSP's gapped (non-prelim): 9512 length of query: 1253 length of database: 18,247,518 effective HSP length: 114 effective length of query: 1139 effective length of database: 13,930,794 effective search space: 15867174366 effective search space used: 15867174366 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.8 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.