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Search of human proteins with 197313730
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|197313730 pleckstrin homology-like domain, family B, member
2 isoform a [Homo sapiens]
(1253 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197313732 pleckstrin homology-like domain, family B, member 2... 2467 0.0
gi|197313730 pleckstrin homology-like domain, family B, member 2... 2467 0.0
gi|197313728 pleckstrin homology-like domain, family B, member 2... 2364 0.0
gi|21955172 pleckstrin homology-like domain, family B, member 2 ... 2364 0.0
gi|221219026 pleckstrin homology-like domain, family B, member 1... 625 e-179
gi|221219024 pleckstrin homology-like domain, family B, member 1... 620 e-177
gi|38424073 pleckstrin homology-like domain, family B, member 1 ... 620 e-177
gi|157266264 pleckstrin homology-like domain, family B, member 3... 201 5e-51
gi|21735548 centrosomal protein 2 [Homo sapiens] 67 1e-10
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 67 1e-10
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 66 2e-10
gi|115511012 coiled-coil domain containing 136 [Homo sapiens] 66 2e-10
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 65 3e-10
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 65 4e-10
gi|71061468 centromere protein E [Homo sapiens] 65 4e-10
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 64 7e-10
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom... 64 7e-10
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 64 1e-09
gi|38044112 restin isoform b [Homo sapiens] 62 3e-09
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 62 3e-09
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 62 4e-09
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 62 4e-09
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 61 6e-09
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 61 6e-09
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 61 6e-09
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 61 6e-09
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 61 6e-09
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 60 1e-08
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 60 1e-08
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 60 2e-08
>gi|197313732 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 2467 bits (6395), Expect = 0.0
Identities = 1253/1253 (100%), Positives = 1253/1253 (100%)
Query: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
Query: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
Query: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
Query: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
Query: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
Query: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
Query: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
Query: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
Query: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
Query: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK
Sbjct: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
Query: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ
Sbjct: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
Query: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP
Sbjct: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
Query: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP
Sbjct: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
Query: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960
RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN
Sbjct: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960
Query: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020
HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS
Sbjct: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020
Query: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080
PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR
Sbjct: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080
Query: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140
LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS
Sbjct: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140
Query: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200
ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD
Sbjct: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200
Query: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253
HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Sbjct: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253
>gi|197313730 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 2467 bits (6395), Expect = 0.0
Identities = 1253/1253 (100%), Positives = 1253/1253 (100%)
Query: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
Query: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
Query: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
Query: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
Query: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
Query: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
Query: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
Query: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
Query: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
Query: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK
Sbjct: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
Query: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ
Sbjct: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
Query: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP
Sbjct: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
Query: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP
Sbjct: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
Query: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960
RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN
Sbjct: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960
Query: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020
HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS
Sbjct: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020
Query: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080
PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR
Sbjct: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080
Query: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140
LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS
Sbjct: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140
Query: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200
ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD
Sbjct: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200
Query: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253
HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Sbjct: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253
>gi|197313728 pleckstrin homology-like domain, family B, member 2
isoform b [Homo sapiens]
Length = 1237
Score = 2364 bits (6126), Expect = 0.0
Identities = 1210/1253 (96%), Positives = 1210/1253 (96%), Gaps = 43/1253 (3%)
Query: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 28 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 87
Query: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 88 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 147
Query: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 148 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 207
Query: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 208 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 267
Query: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 268 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 327
Query: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 328 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 387
Query: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 388 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 447
Query: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 448 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 507
Query: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 508 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 567
Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 568 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 627
Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 628 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 687
Query: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
IVGEKTK DADLLDVESK
Sbjct: 688 IVGEKTK-------------------------------------------DADLLDVESK 704
Query: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ
Sbjct: 705 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
Query: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP
Sbjct: 765 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 824
Query: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP
Sbjct: 825 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 884
Query: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960
RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN
Sbjct: 885 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 944
Query: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020
HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS
Sbjct: 945 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1004
Query: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080
PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR
Sbjct: 1005 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1064
Query: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140
LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS
Sbjct: 1065 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1124
Query: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200
ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD
Sbjct: 1125 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1184
Query: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253
HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Sbjct: 1185 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1237
>gi|21955172 pleckstrin homology-like domain, family B, member 2
isoform c [Homo sapiens]
Length = 1210
Score = 2364 bits (6126), Expect = 0.0
Identities = 1210/1253 (96%), Positives = 1210/1253 (96%), Gaps = 43/1253 (3%)
Query: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
Query: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
Query: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
Query: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
Query: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
Query: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
Query: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
Query: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
Query: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
Query: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
IVGEKTK DADLLDVESK
Sbjct: 661 IVGEKTK-------------------------------------------DADLLDVESK 677
Query: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ
Sbjct: 678 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 737
Query: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP
Sbjct: 738 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 797
Query: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP
Sbjct: 798 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 857
Query: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960
RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN
Sbjct: 858 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 917
Query: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020
HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS
Sbjct: 918 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 977
Query: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080
PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR
Sbjct: 978 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1037
Query: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140
LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS
Sbjct: 1038 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1097
Query: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200
ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD
Sbjct: 1098 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1157
Query: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253
HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Sbjct: 1158 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1210
>gi|221219026 pleckstrin homology-like domain, family B, member 1
isoform b [Homo sapiens]
Length = 1319
Score = 625 bits (1612), Expect = e-179
Identities = 386/881 (43%), Positives = 513/881 (58%), Gaps = 167/881 (18%)
Query: 407 PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 465
P RERK+SI+ IS DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D
Sbjct: 570 PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629
Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
G ++ I + L L+ P LA
Sbjct: 630 ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663
Query: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
S T R + E SD SST S++ + E +
Sbjct: 664 SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
E+ A+EE R +L ++E+LK ++K++ Q+ ES RE +ME ALL G
Sbjct: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQG-------------- 757
Query: 646 ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQ 705
E+ E+ L E++ +++LQE +T + Q
Sbjct: 758 ------------------EREAERALLQKEQKAVDQLQEKLVALETGI-----------Q 788
Query: 706 QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765
++ ++A+ L+ E+K FEDLEFQQLE ESR++EE+E Q LLR AE R+I RKE++
Sbjct: 789 KERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERL 848
Query: 766 SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPN 825
+ L QA I QA +E + ++KN + +LQ+EKE L LE++Y SL+GG+ FP +
Sbjct: 849 AILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTS 908
Query: 826 TLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEER 885
TLKE Y S + G +T+ P T+
Sbjct: 909 TLKEVYRSKMD-----GEATSPLPRTR--------------------------------- 930
Query: 886 KKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAA 945
S LP +SS S S AT+GRS +PK+ L N GS LP +LAA
Sbjct: 931 ----------SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLT--QNGTGS-LPRNLAA 977
Query: 946 MAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFH-----------YP 992
+D E++R L + Q + E R+ +E + A+E+ ++ H +P
Sbjct: 978 TLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFP 1037
Query: 993 D---HSYK-------------DQAFDTLSLDSSDSMETSIS-----ACSPDNISSASTSN 1031
HS + A+DTLSL+SSDSMETSIS ACSPDN+SSAS +
Sbjct: 1038 PLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLD 1097
Query: 1032 IARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKL 1091
+ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RRRE +E+RLQ E+++RQ+L
Sbjct: 1098 MGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQL 1157
Query: 1092 IEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLI 1151
+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +DTC HV ++ K CRG+L+
Sbjct: 1158 VEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLV 1217
Query: 1152 KMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNP 1211
KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQAIEEVYYDHL++A KSPNP
Sbjct: 1218 KMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNP 1277
Query: 1212 LLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFL 1252
LTF VKTHDR+YYMVAPS EAMRIWMDVIVTGAEGYT F+
Sbjct: 1278 ALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFM 1318
>gi|221219024 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 620 bits (1600), Expect = e-177
Identities = 388/893 (43%), Positives = 524/893 (58%), Gaps = 133/893 (14%)
Query: 407 PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 465
P RERK+SI+ IS DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D
Sbjct: 570 PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629
Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
G ++ I + L L+ P LA
Sbjct: 630 ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663
Query: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
S T R + E SD SST S++ + E +
Sbjct: 664 SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
E+ A+EE R +L ++E+LK ++K++ Q+ ES RE +ME ALL G
Sbjct: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQG-------------- 757
Query: 646 ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQ 705
E+ E+ L E++ +++LQE +T + Q
Sbjct: 758 ------------------EREAERALLQKEQKAVDQLQEKLVALETGI-----------Q 788
Query: 706 QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765
++ ++A+ L+ E+K FEDLEFQQLE ESR++EE+E Q LLR AE R+I RKE++
Sbjct: 789 KERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERL 848
Query: 766 SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPN 825
+ L QA I QA +E + ++KN + +LQ+EKE L LE++Y SL+GG+ FP +
Sbjct: 849 AILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTS 908
Query: 826 TLKE-GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEE 884
TLKE + + ++ ++ PA A ++ P AS+ + +RS +
Sbjct: 909 TLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASR--QLQVYRSKMD 966
Query: 885 RKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLA 944
+ S LP +SS S S AT+GRS +PK+ L N GS LP +LA
Sbjct: 967 GEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLT--QNGTGS-LPRNLA 1023
Query: 945 AMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFH-----------Y 991
A +D E++R L + Q + E R+ +E + A+E+ ++ H +
Sbjct: 1024 ATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGF 1083
Query: 992 PD---HSYK-------------DQAFDTLSLDSSDSMETSIS-----ACSPDNISSASTS 1030
P HS + A+DTLSL+SSDSMETSIS ACSPDN+SSAS
Sbjct: 1084 PPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGL 1143
Query: 1031 NIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1090
++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RRRE +E+RLQ E+++RQ+
Sbjct: 1144 DMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQ 1203
Query: 1091 LIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFL 1150
L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +DTC HV ++ K CRG+L
Sbjct: 1204 LVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYL 1263
Query: 1151 IKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANK--- 1207
+KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQAIEEVYYDHL++A K
Sbjct: 1264 VKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRF 1323
Query: 1208 --------SPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFL 1252
SPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIVTGAEGYT F+
Sbjct: 1324 FRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFM 1376
Score = 34.3 bits (77), Expect = 0.77
Identities = 91/427 (21%), Positives = 157/427 (36%), Gaps = 59/427 (13%)
Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLERQR 449
E+ +E R+ +G Q LR + + SI+ R + + Q + + QE ERL R +
Sbjct: 816 ESRVEEERELAG--QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDK 873
Query: 450 LETILSLCAEYTKPD------SRLSTGTTVEDVQKINKELEKLQLS--DEESVFEEALMS 501
++ L E K L+ G KE+EKL L D E ++E +
Sbjct: 874 NASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAG 933
Query: 502 PDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDL--TRTPPPPSSTFP 559
T S P A ++S RS + E S L TR+ P PSS+
Sbjct: 934 LGTGPAAASPHSSPPPLPA------KASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGS 987
Query: 560 KASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLE-----ELKQKIKDINDQ 614
+SS ++ L ++P S ++ L ++E L+QK + + ++
Sbjct: 988 SSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEE 1047
Query: 615 MDESFRELDMECALLDGEQKSETTEL---------------MKEKEILDHLNRKIAELEK 659
EL + A E + + L + IL HL A E+
Sbjct: 1048 QRRRLAELKQKAA---AEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLP---AGRER 1101
Query: 660 NIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP----------ESMREQLQQQLK 709
GE + + L++ + +E DN E M + L++
Sbjct: 1102 GEEGEHAYDTLSLESS-DSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHA 1160
Query: 710 RDADLLDVESKHFEDLEFQQLEHESRLDEEKE-NLTQQLLREVAEYQRNIVSRKEKISAL 768
L++ + E L Q LE E R E+ E L + R ++ + R+++ S
Sbjct: 1161 EKNRLMESREREME-LRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQA 1219
Query: 769 KKQANHI 775
+ ++
Sbjct: 1220 RPLTRYL 1226
>gi|38424073 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 620 bits (1600), Expect = e-177
Identities = 388/893 (43%), Positives = 524/893 (58%), Gaps = 133/893 (14%)
Query: 407 PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 465
P RERK+SI+ IS DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D
Sbjct: 570 PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629
Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
G ++ I + L L+ P LA
Sbjct: 630 ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663
Query: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
S T R + E SD SST S++ + E +
Sbjct: 664 SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
E+ A+EE R +L ++E+LK ++K++ Q+ ES RE +ME ALL G
Sbjct: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQG-------------- 757
Query: 646 ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQ 705
E+ E+ L E++ +++LQE +T + Q
Sbjct: 758 ------------------EREAERALLQKEQKAVDQLQEKLVALETGI-----------Q 788
Query: 706 QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765
++ ++A+ L+ E+K FEDLEFQQLE ESR++EE+E Q LLR AE R+I RKE++
Sbjct: 789 KERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERL 848
Query: 766 SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPN 825
+ L QA I QA +E + ++KN + +LQ+EKE L LE++Y SL+GG+ FP +
Sbjct: 849 AILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTS 908
Query: 826 TLKE-GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEE 884
TLKE + + ++ ++ PA A ++ P AS+ + +RS +
Sbjct: 909 TLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASR--QLQVYRSKMD 966
Query: 885 RKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLA 944
+ S LP +SS S S AT+GRS +PK+ L N GS LP +LA
Sbjct: 967 GEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLT--QNGTGS-LPRNLA 1023
Query: 945 AMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFH-----------Y 991
A +D E++R L + Q + E R+ +E + A+E+ ++ H +
Sbjct: 1024 ATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGF 1083
Query: 992 PD---HSYK-------------DQAFDTLSLDSSDSMETSIS-----ACSPDNISSASTS 1030
P HS + A+DTLSL+SSDSMETSIS ACSPDN+SSAS
Sbjct: 1084 PPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGL 1143
Query: 1031 NIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1090
++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RRRE +E+RLQ E+++RQ+
Sbjct: 1144 DMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQ 1203
Query: 1091 LIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFL 1150
L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +DTC HV ++ K CRG+L
Sbjct: 1204 LVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYL 1263
Query: 1151 IKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANK--- 1207
+KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQAIEEVYYDHL++A K
Sbjct: 1264 VKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRF 1323
Query: 1208 --------SPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFL 1252
SPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIVTGAEGYT F+
Sbjct: 1324 FRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFM 1376
Score = 34.3 bits (77), Expect = 0.77
Identities = 91/427 (21%), Positives = 157/427 (36%), Gaps = 59/427 (13%)
Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLERQR 449
E+ +E R+ +G Q LR + + SI+ R + + Q + + QE ERL R +
Sbjct: 816 ESRVEEERELAG--QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDK 873
Query: 450 LETILSLCAEYTKPD------SRLSTGTTVEDVQKINKELEKLQLS--DEESVFEEALMS 501
++ L E K L+ G KE+EKL L D E ++E +
Sbjct: 874 NASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAG 933
Query: 502 PDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDL--TRTPPPPSSTFP 559
T S P A ++S RS + E S L TR+ P PSS+
Sbjct: 934 LGTGPAAASPHSSPPPLPA------KASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGS 987
Query: 560 KASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLE-----ELKQKIKDINDQ 614
+SS ++ L ++P S ++ L ++E L+QK + + ++
Sbjct: 988 SSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEE 1047
Query: 615 MDESFRELDMECALLDGEQKSETTEL---------------MKEKEILDHLNRKIAELEK 659
EL + A E + + L + IL HL A E+
Sbjct: 1048 QRRRLAELKQKAA---AEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLP---AGRER 1101
Query: 660 NIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP----------ESMREQLQQQLK 709
GE + + L++ + +E DN E M + L++
Sbjct: 1102 GEEGEHAYDTLSLESS-DSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHA 1160
Query: 710 RDADLLDVESKHFEDLEFQQLEHESRLDEEKE-NLTQQLLREVAEYQRNIVSRKEKISAL 768
L++ + E L Q LE E R E+ E L + R ++ + R+++ S
Sbjct: 1161 EKNRLMESREREME-LRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQA 1219
Query: 769 KKQANHI 775
+ ++
Sbjct: 1220 RPLTRYL 1226
>gi|157266264 pleckstrin homology-like domain, family B, member 3
[Homo sapiens]
Length = 640
Score = 201 bits (510), Expect = 5e-51
Identities = 111/212 (52%), Positives = 130/212 (61%), Gaps = 31/212 (14%)
Query: 1035 IEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEK 1094
I MERLL+QA AE+ RLL++R E +R E
Sbjct: 455 IAHMERLLQQAMAERERLLKAR----EGTRRGTEGSSG---------------------- 488
Query: 1095 EVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMG 1154
A P T P DLR H+E GHN + C HV ++ CRG L+KMG
Sbjct: 489 -----PAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMG 543
Query: 1155 GKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLT 1214
G+IKTW+KRWF FDR R +YYADK ETKLKGVIYFQAIEEVYYDHL+ A KSPNP LT
Sbjct: 544 GRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLT 603
Query: 1215 FSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAE 1246
F VKT++R++YMVAPSPEAMRIWMDVIVT A+
Sbjct: 604 FCVKTYERLFYMVAPSPEAMRIWMDVIVTAAD 635
Score = 114 bits (284), Expect = 8e-25
Identities = 110/418 (26%), Positives = 189/418 (45%), Gaps = 66/418 (15%)
Query: 550 TPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIK 609
TPP + P AS+ S + G + + Q+L A+ TR+ ++ +Q++K
Sbjct: 75 TPPIAMAATPPASTSSR------EGVRGAARRLQGQQLEAL--TRVALM------EQRVK 120
Query: 610 DINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEK 669
++ Q E E+++E ALL GE E +E+E L L + A E+ ++ +E+
Sbjct: 121 ELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQ 180
Query: 670 VKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQ 729
+L ER++LE L++ + + QLD+ PE RE+L Q ++ + LDV + +EDLEFQQ
Sbjct: 181 RRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQ 240
Query: 730 LEHESRLDEEKEN---------LTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
LE ESR +EE + Q+L +A+++R + + +I L++Q + +Q
Sbjct: 241 LERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGAL--QHRIRVLEEQLKSLGEQMA 298
Query: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
E ++K + L +E+ L L + L G G + +EP
Sbjct: 299 AESRGLSRKKEEALQALSQERSRLLEL----NCLQGTPG---------------GDFSEP 339
Query: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
T L + + D + + A A A+ P S F Q GL + +LP
Sbjct: 340 NPALTKLLFTQK--TDRQLLVLQDAVAHSAATPTSSCLFS--VHSSLQGSIGLQRTGSLP 395
Query: 901 RKK--------TTSSISPHFSSATMGRSITP----KAHLPL------GQSNSCGSVLP 940
RK+ + +S H + + ++ P PL G+ NSCG++ P
Sbjct: 396 RKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHP 453
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 67.0 bits (162), Expect = 1e-10
Identities = 118/594 (19%), Positives = 248/594 (41%), Gaps = 93/594 (15%)
Query: 573 KTPEGISEEQRSQELA-----------AMEETRIVILNNLEELKQKIKDINDQMDESFRE 621
K E SE +R+Q L A++E ++ L E +++++ + Q+ E ++
Sbjct: 1391 KNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ 1450
Query: 622 LDMECALLD-------------GEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKE 668
+M+ A L+ Q+ + EL K + +L+HL + E E+ + ++ +
Sbjct: 1451 REMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI 1510
Query: 669 KVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADL----LDVESKHFED 724
+ +L+ +RE + E + + D ES R Q+Q K+ L L++E H +
Sbjct: 1511 R-ELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK- 1568
Query: 725 LEFQQL---EHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQR 781
+E QQ E E + + ++ LT L ++ E + + ++ +I L+ + + ++ Q
Sbjct: 1569 MECQQKLIKELEGQRETQRVALTHLTL-DLEERSQELQAQSSQIHDLESHSTVLARELQ- 1626
Query: 782 EQDHFVKEKNNLIMMLQREKENLC-NLEKKYSSL------------SGGKGFPVNPNTLK 828
E+D VK + I LQR+KE+L +LE++ L + + L+
Sbjct: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686
Query: 829 EGYISVNEINEPCGNSTNL----SPSTQFPADADAVATEPATAVLASQPQ----SKEHFR 880
+ +S+ E L + + P+ A + E +L + + +EH
Sbjct: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746
Query: 881 SLEERKKQHKEGLYLSDTLPRKKTTSSI---SPHFSSATMGRSITPKAHLPLGQSNSCGS 937
L+E K Q ++ L L RK +S+ + + + + S S
Sbjct: 1747 ELQELKDQLEQQL---QGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQS 1803
Query: 938 VLPPSLAAMAKDSESRRMLRGYNHQQMSEGH----RQKSEFYNRTASESNVYLNSFHYPD 993
L + A+A+ + L+ QQ ++G ++K++ ++++ L H
Sbjct: 1804 QLDEAQRALAQRDQELEALQ--QEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGEL 1861
Query: 994 HSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLL 1053
+K+QA L+ ++E R++ +E +L AE
Sbjct: 1862 QDHKEQA---RRLEEELAVEG------------------RRVQALEEVLGDLRAES---- 1896
Query: 1054 ESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQAR 1107
+E+ + A ++ E+ + E+ + LQ+ Q Q ++++ + E RA+++
Sbjct: 1897 REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQ 1950
Score = 60.5 bits (145), Expect = 1e-08
Identities = 131/596 (21%), Positives = 246/596 (41%), Gaps = 103/596 (17%)
Query: 581 EQRSQELAA-------MEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ 633
E+RSQEL A +E V+ L+E Q++K +Q++E R+ E D E+
Sbjct: 1598 EERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQ--KEHLTQDLER 1655
Query: 634 KSETTELMKEK-EIL-DHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKT 691
+ + L KE+ ++L D R+ LE+++ E++KL ER +EL ++++
Sbjct: 1656 RDQELMLQKERIQVLEDQRTRQTKILEEDL------EQIKLSLR----ERGRELTTQRQL 1705
Query: 692 QLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL--- 748
+ E Q+ + L + K +++E QQ EH L E K+ L QQL
Sbjct: 1706 MQERAEEGKGPSKAQRGSLEHMKLILRDKE-KEVECQQ-EHIHELQELKDQLEQQLQGLH 1763
Query: 749 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 808
R+V E + R+++I L++Q +Q + ++ + + L + + L L+
Sbjct: 1764 RKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQ 1823
Query: 809 KKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAV 868
++ G + +KE ADA A E A
Sbjct: 1824 QEQQQAQGQE------ERVKE------------------------KADALQGALEQAHMT 1853
Query: 869 LASQ----PQSKEHFRSLEE------RKKQHKE---GLYLSDTLPRKKTTSSISPHFSSA 915
L + KE R LEE R+ Q E G +++ ++K ++ +
Sbjct: 1854 LKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQ 1913
Query: 916 TMGRSITPKAHLPLG-QSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEF 974
+ +A Q+ + L A+ +S+S R HQ+ E R ++E
Sbjct: 1914 AQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSR------HQE--EAARARAEA 1965
Query: 975 YNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDS-METSISACSPDNISSASTSNIA 1033
+++ L + +QA + SL++S + ++ S+ AC + I
Sbjct: 1966 LQEALGKAHAALQG---KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQ 2022
Query: 1034 ---------RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEE 1084
R +E + L+QA A++ L R + +++ LE+ +R + E +QE+
Sbjct: 2023 EGEIQDQDLRYQEDVQQLQQALAQRDEEL----RHQQEREQLLEKSLAQR-VQENMIQEK 2077
Query: 1085 TSQRQKLIEKEVK-----IRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDT 1135
+ Q+ E+E++ +RE Q A+ L +R + R+++E H+ T
Sbjct: 2078 QNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELR--ETQQRNNLEALPHSHKT 2131
Score = 53.1 bits (126), Expect = 2e-06
Identities = 126/582 (21%), Positives = 237/582 (40%), Gaps = 97/582 (16%)
Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQM---DESFRELDMECALLDGEQKSETT 638
Q +LAA++E +L + +L+++++D+ Q+ D+S R ++ E E+ ET
Sbjct: 986 QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQ----EKLRETQ 1041
Query: 639 ELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPE 698
E + ++K + EK + L + ++L LQE S ++ +L +
Sbjct: 1042 EYNR--------------IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQ 1087
Query: 699 SMREQL--QQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKE--NLTQQLLR----- 749
M+E Q++L +LL E K + E L E++L EE E ++T+Q LR
Sbjct: 1088 DMQEAQGEQKELSAQMELLRQEVK---EKEADFLAQEAQLLEELEASHITEQQLRASLWA 1144
Query: 750 ---EVAEYQ---RNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKEN 803
+ A+ Q R+ S+ E ++A ++ N QAQ +L LQ+ +
Sbjct: 1145 QEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLA---------SLYSALQQALGS 1195
Query: 804 LCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPS----TQFPADADA 859
+C + S GG P SV + + +L T A+A A
Sbjct: 1196 VCESRPELS--GGGDSAP-----------SVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242
Query: 860 VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGR 919
A L Q+++ R ++ ++ L+DT K H + R
Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEER-----LTDTEAEKSQV-----HTELQDLQR 1292
Query: 920 SITPKAHLPL---GQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN 976
++ G+ NS S L MA S R+ R + ++G R+ +
Sbjct: 1293 QLSQNQEEKSKWEGKQNSLESELMELHETMA--SLQSRLRRAELQRMEAQGERELLQ--- 1347
Query: 977 RTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIE 1036
A++ N+ H + +A + + + + T+ SA N S A+
Sbjct: 1348 --AAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQAL 1405
Query: 1037 EMERLLKQAHAEK--------TRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQR 1088
+ + LK A + T+ L RE E+E + ++E +++RE ++K E S
Sbjct: 1406 QEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQRE-MQKAALELLSLD 1464
Query: 1089 QKLIEKEVKIRERQ---RAQARPLTRYLPVRKEDFDLRSHVE 1127
K +EV +++ Q + R + +LP+ ++ + + V+
Sbjct: 1465 LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQ 1506
Score = 50.8 bits (120), Expect = 8e-06
Identities = 52/226 (23%), Positives = 109/226 (48%), Gaps = 24/226 (10%)
Query: 585 QELAAMEETRIVILNNLEELKQKIKDINDQMD--ESFRELDMECALLDGEQKSETTELMK 642
QE A+ + + L+ +++ +D+ +Q+ S +EL +E +L + +Q++ E+ K
Sbjct: 729 QEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKEL-LESSLFEAQQQNSVIEVTK 787
Query: 643 EKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMRE 702
+ L+ + + + ++ I GE K++LD ER + E+ ++ + Q Q + ++ E
Sbjct: 788 GQ--LEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE 845
Query: 703 QLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRK 762
Q + +++ + L E E ++ H+ L + E+L RE E + + ++
Sbjct: 846 QQKAAHEKEVNQLR------EKWEKERSWHQQELAKALESLE----REKMELEMRLKEQQ 895
Query: 763 EKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 808
++ A+ QAQRE++ E M L+ EKE + LE
Sbjct: 896 TEMEAI---------QAQREEERTQAESALCQMQLETEKERVSLLE 932
Score = 49.3 bits (116), Expect = 2e-05
Identities = 108/505 (21%), Positives = 210/505 (41%), Gaps = 52/505 (10%)
Query: 427 DYHRRQREERLREQEMERLERQRL-ETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEK 485
D + Q+EE+ E + ER+RL E ++ L A+ ++ S L T + + EL +
Sbjct: 501 DSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLR 560
Query: 486 LQLSDEESVFEEALMSPDTRYRCHRKDSLPDADL-ASCGSLSQSSASFFTPRSTRNDELL 544
+ ++ + A S ADL A+ LS + + + N +LL
Sbjct: 561 QEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLL 620
Query: 545 SDLTRTPPPPSSTFPKASSESSYLSI----LPKTPEGISEEQRSQE--LAAMEETRIVIL 598
L S A + L + K E + E+ E L EE +
Sbjct: 621 -QLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQ 679
Query: 599 NNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELE 658
+L +++++ ++I ++ ES + E A EQ + E +++E+ L R + E E
Sbjct: 680 ADLRDIQEEKEEIQKKLSESRHQ--QEAATTQLEQLHQ--EAKRQEEV---LARAVQEKE 732
Query: 659 KNIVGEKTKEKVKLDA-EREK---LERLQELYSEQK---------TQLDNCPESMREQLQ 705
+V EK +V+L A ER++ E+LQ L S ++ Q ++ E + QL+
Sbjct: 733 A-LVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLE 791
Query: 706 QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765
Q++ +V L+ + S+ ++E++ +QL + E + + +K
Sbjct: 792 VQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQK--- 848
Query: 766 SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENL-CNLEKKYSSLSGGKGFPVNP 824
+A +K+ N + ++ ++E+ +E + L+REK L L+++ + + +
Sbjct: 849 AAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEE 908
Query: 825 NTLKEGYISVNEINEPCGNSTNLSPSTQFPAD-ADA---------------VATEPATAV 868
T E + ++ + L Q + ADA + + T +
Sbjct: 909 RTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI 968
Query: 869 LASQPQSKEHFRSLEERKKQHKEGL 893
L Q Q +E R L+E +QH++ L
Sbjct: 969 L--QTQLQEAQRELKEAARQHRDDL 991
Score = 48.5 bits (114), Expect = 4e-05
Identities = 142/736 (19%), Positives = 277/736 (37%), Gaps = 97/736 (13%)
Query: 417 SSISGRDDLMDYHRRQREERLRE-QEMERLERQRLETILSLCAEYTKPDSRLSTGTTVED 475
S + +DD ++ +E+LRE QE R++++ SL + + RL +
Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADS 1076
Query: 476 VQKINKELEKLQLSDEESVFEEALMSPDTRY-RCHRKDSLPDADLASCGSLSQSSASFFT 534
+++ +EL L+ +E+ E+ +S R K+ D L + AS T
Sbjct: 1077 IRQ--QELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHIT 1134
Query: 535 PRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETR 594
+ R + L + + S S L L + ++ Q +LA++
Sbjct: 1135 EQQLR-----ASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSAL 1189
Query: 595 IVILNNLEELKQKIKDINDQMDESF---------RELDMECALLDGEQKSETT------- 638
L ++ E + ++ D + R L LL
Sbjct: 1190 QQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249
Query: 639 -ELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP 697
+L K ++ D L ++ +LE+ + + EK ++ E + L+R E+K++ +
Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEA-EKSQVHTELQDLQRQLSQNQEEKSKWEGKQ 1308
Query: 698 ESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESR---LDEEKENLTQQLLREVAEY 754
S+ +L + + A L E Q++E + L KENLT Q V
Sbjct: 1309 NSLESELMELHETMASL----QSRLRRAELQRMEAQGERELLQAAKENLTAQ----VEHL 1360
Query: 755 QRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 814
Q +V + + SA I+++ R +K KN + + E+E L+++ L
Sbjct: 1361 QAAVVEARAQASAAG-----ILEEDLRTARSALKLKNEEV---ESERERAQALQEQ-GEL 1411
Query: 815 SGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQ 874
+G L+E NL+ TQ A+ E L Q Q
Sbjct: 1412 KVAQG-----KALQE----------------NLALLTQTLAER-----EEEVETLRGQIQ 1445
Query: 875 SKEHFRSLEERKKQHKEGLYLS--DTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQS 932
LE++++ K L L D R + RS+ + + +
Sbjct: 1446 E------LEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQER 1499
Query: 933 NSCGSVLPPSLAAMAKDSESRR------MLRGYNHQQMSEGHRQKSEFYNRTASESNVYL 986
+V + + KD E++R +L QM E Q+ + + +
Sbjct: 1500 EQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIES--QRGQVQDLKKQLVTLEC 1557
Query: 987 NSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAH 1046
+ ++ +K + L + ET A + + S + + + ++H
Sbjct: 1558 LALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESH 1617
Query: 1047 AEK-TRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQ 1105
+ R L+ R++E+++++ +EE +R++E L + L E Q L ++ +++ E QR
Sbjct: 1618 STVLARELQERDQEVKSQREQIEELQRQKEHLTQDL-ERRDQELMLQKERIQVLEDQR-- 1674
Query: 1106 ARPLTRYLPVRKEDFD 1121
TR + +ED +
Sbjct: 1675 ----TRQTKILEEDLE 1686
Score = 47.8 bits (112), Expect = 7e-05
Identities = 52/242 (21%), Positives = 110/242 (45%), Gaps = 16/242 (6%)
Query: 580 EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTE 639
+ +R +E A+E R+ LEE+ ++ + + +++ L +CA E + ET
Sbjct: 1867 QARRLEEELAVEGRRV---QALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRA 1923
Query: 640 L----MKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDN 695
L ++ + +L ++++ L + +E +A R + E LQE + L
Sbjct: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQE----EAARARAEALQEALGKAHAALQG 1979
Query: 696 CPESMREQLQQQLKRDADLLDVE-SKHFEDLEFQQLEHESRLDE-EKENLTQQLLREVAE 753
+ + EQ + +A ++ S +QLE R+ E E ++ + +V +
Sbjct: 1980 KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ 2039
Query: 754 YQRNIVSRKEKISALKKQANHIVQQ-AQREQDHFVKEKNNLIMMLQREKENLCNLEKKYS 812
Q+ + R E++ +++ + + AQR Q++ ++EK NL +RE+E + L +
Sbjct: 2040 LQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQ--EREEEEIRGLHQSVR 2097
Query: 813 SL 814
L
Sbjct: 2098 EL 2099
Score = 47.0 bits (110), Expect = 1e-04
Identities = 138/765 (18%), Positives = 295/765 (38%), Gaps = 93/765 (12%)
Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 451
EA L+ +A Q LR+ + I + + R Q+E + E E +R E
Sbjct: 665 EAQLQKAEEAGAELQADLRDIQEEKEEIQKK---LSESRHQQEAATTQLEQLHQEAKRQE 721
Query: 452 TILSLCAEYTKPDSRLSTGTTV--EDVQKINKEL-EKLQ-LSDEESVFEEALMSPDTRYR 507
+L+ + + R V + V++ ++L E+LQ LS + + E +L +
Sbjct: 722 EVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSL------FE 775
Query: 508 CHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSY 567
+++S+ + + G L + + E+ S + + +
Sbjct: 776 AQQQNSVIEV---TKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQ 832
Query: 568 LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQ----MDESFRELD 623
L+ + + E+Q+ AA E+ +N L E +K + + Q ES
Sbjct: 833 LAQAEQEGKTALEQQK----AAHEKE----VNQLREKWEKERSWHQQELAKALESLEREK 884
Query: 624 MECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQ 683
ME + EQ++E + ++E E+ E +++L+ E+E++ L+
Sbjct: 885 MELEMRLKEQQTEMEAIQAQRE------------EERTQAESALCQMQLETEKERVSLLE 932
Query: 684 ELYSEQKTQLDNCP--ESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKE 741
L QK D E +R+ ++ Q ++ + + ++ + + E + ++
Sbjct: 933 TLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLA 992
Query: 742 NLTQQ---LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQ 798
L ++ LL++ + Q+ + K ++ A + + +V+Q +E+ +E N + L+
Sbjct: 993 ALQEESSSLLQDKMDLQKQVEDLKSQLVA-QDDSQRLVEQEVQEKLRETQEYNRIQKELE 1051
Query: 799 REKEN--LCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPAD 856
REK + L +EK+ L + + L ++ E G LS +
Sbjct: 1052 REKASLTLSLMEKEQRLLVLQEADSIRQQELS---ALRQDMQEAQGEQKELSAQMELLRQ 1108
Query: 857 ADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDT------LPRKKTTSSISP 910
E LA + Q E + ++Q + L+ + L + T S +
Sbjct: 1109 E---VKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEA 1165
Query: 911 HFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQ 970
+ G +A L S S L +L ++ ESR L G S +
Sbjct: 1166 LAAEQQPGNQAQAQAQLA-----SLYSALQQALGSVC---ESRPELSGGGDSAPSVWGLE 1217
Query: 971 KSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTS 1030
+ R+ + L + S++++ +++ D + T
Sbjct: 1218 PDQNGARSLFKRGPLLTAL------------------SAEAVASALHKLHQDLWKTQQTR 1259
Query: 1031 NIAR--IEEMERLLKQAHAEKTRL---LESREREMEAKKRALEEEKRRREILEKRLQEET 1085
++ R ++++E L AEK+++ L+ +R++ + + + ++ LE L E
Sbjct: 1260 DVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELM-EL 1318
Query: 1086 SQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR-SHVETA 1129
+ ++ ++ E QR +A+ L KE+ + H++ A
Sbjct: 1319 HETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAA 1363
Score = 41.6 bits (96), Expect = 0.005
Identities = 123/711 (17%), Positives = 278/711 (39%), Gaps = 92/711 (12%)
Query: 427 DYHRRQREERLREQEMERLERQRLE-TILSLCAEYTKPDSRLSTGTTVEDVQKINKELEK 485
++H+ + +++L ++ + E QR+ T L+L E + + + + + D++ + L +
Sbjct: 1565 NHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQS-SQIHDLESHSTVLAR 1623
Query: 486 -LQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELL 544
LQ D+E + + R + H L D L + + TR ++L
Sbjct: 1624 ELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELM--LQKERIQVLEDQRTRQTKIL 1681
Query: 545 S-DLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEE 603
DL + + +++ + + +G S+ QR ++E ++++ + +E
Sbjct: 1682 EEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRG----SLEHMKLILRDKEKE 1737
Query: 604 LK------QKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAEL 657
++ +++++ DQ+++ + L + ET+ L+ ++E ++I L
Sbjct: 1738 VECQQEHIHELQELKDQLEQQLQGLHRKVG--------ETSLLLSQRE------QEIVVL 1783
Query: 658 EKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV 717
++ + + + ++K + + +L+ Q +++ +L+ + ++Q Q Q +R + D
Sbjct: 1784 QQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE-QQQAQGQEERVKEKADA 1842
Query: 718 ESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH--- 774
E E L + KE ++L E+A R + + +E + L+ ++
Sbjct: 1843 LQGALEQAHMTLKERHGELQDHKEQ-ARRLEEELAVEGRRVQALEEVLGDLRAESREQEK 1901
Query: 775 ----IVQQ-AQREQDHFVKEKNNLIMMLQRE---KENLCNLE----KKYSSLSGGKGFPV 822
+ QQ A++ Q+H V+ + LQ + KE LE + SS +
Sbjct: 1902 ALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARA 1961
Query: 823 NPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSK--EHFR 880
L+E + + G +L + +A ++ A Q S+ E
Sbjct: 1962 RAEALQEALGKAHAALQ--GKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL 2019
Query: 881 SLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLP 940
++E + Q ++ Y D ++ + + K+ Q N
Sbjct: 2020 RIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQE--K 2077
Query: 941 PSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQA 1000
+L ++ E R + + Q++ +++ R + N + HS+K
Sbjct: 2078 QNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRN----NLEALPHSHKTSP 2133
Query: 1001 FDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREM 1060
+ SL DS+E + E+ERL + R +E RE+
Sbjct: 2134 MEEQSL-KLDSLEPRLQ------------------RELERLQAALRQTEAREIEWREKAQ 2174
Query: 1061 E-----AKKRA-----------LEEEKRRREILEKRLQEETSQRQKLIEKE 1095
+ A+ +A L+ R+ ++RLQ+E ++ +EKE
Sbjct: 2175 DLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE 2225
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 66.6 bits (161), Expect = 1e-10
Identities = 125/596 (20%), Positives = 230/596 (38%), Gaps = 75/596 (12%)
Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMD----------------ESFR-ELD 623
E+ ++L +E R V+ L E+++ + Q D E+ R EL+
Sbjct: 662 ERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELE 721
Query: 624 MECALLDGEQKSETTELMKEKEILDHL-------NRKIAELEKN---IVGEKTKEKVKLD 673
+ L E+ S L K + + L NR +A+LE+ + G + + + +
Sbjct: 722 LSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT 781
Query: 674 AEREKLERLQELYSEQKTQLDNCPESMR--EQLQQQLKRDADLLDVESKHFEDLEFQQLE 731
RE+ ERL+EL EQ+ S+R EQ Q+ L++ L E ++ Q
Sbjct: 782 VAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSR 841
Query: 732 HESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ--QAQREQDHFVKE 789
S ++E E ++ R+V +R + +EK + K+ A VQ A+RE +E
Sbjct: 842 QLSGREQELEQARREAQRQVEALER---AAREKEALAKEHAGLAVQLVAAEREGRTLSEE 898
Query: 790 KNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSP 849
L + + + +L ++++ + L + EG + G L
Sbjct: 899 ATRLRLEKEALEGSLFEVQRQLAQLEARR-----EQLEAEGQALLLAKETLTGELAGLRQ 953
Query: 850 STQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSIS 909
Q A + + + +E SL E++ H+E L L R+K +
Sbjct: 954 --QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL---QRLQREKEAAWRE 1008
Query: 910 PHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHR 969
A + + + L + + L +AA+ ++ + +L
Sbjct: 1009 LEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLL----------AES 1058
Query: 970 QKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNIS-SAS 1028
+K + + SE HS T+SL+ + S D + +A
Sbjct: 1059 EKQQALSLKESEKTALSEKLMGTRHSLA-----TISLEMERQKRDAQSRQEQDRSTVNAL 1113
Query: 1029 TSNIARIEEMERLLKQAHAEKTRLLESREREM-EAKKRALEEEKRRREILEKRLQEETSQ 1087
TS + + AHA++ R L+ + R++ + + L E + R L
Sbjct: 1114 TSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGL 1173
Query: 1088 RQKLIEKEVKIRER------QRAQARPLTRYL--------PVRKEDFDLRSHVETA 1129
R++L+E + K+RE QR +A L R L +R+ + +LRS V+ A
Sbjct: 1174 RRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKA 1229
Score = 55.5 bits (132), Expect = 3e-07
Identities = 92/452 (20%), Positives = 181/452 (40%), Gaps = 44/452 (9%)
Query: 369 LAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDY 428
LAG ++ AT+ S E + L QA Q +LRE++++ ++ +
Sbjct: 948 LAGLRQQIIATQEKASLDK----ELMAQKLVQAEREAQASLREQRAA------HEEDLQR 997
Query: 429 HRRQREERLREQEMER------LERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKE 482
+R++E RE E ER L+R++ E + L AE + ++ D + E
Sbjct: 998 LQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE 1057
Query: 483 LEKLQL----SDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRST 538
EK Q E++ E LM TR+ + S + S ++
Sbjct: 1058 SEKQQALSLKESEKTALSEKLMG--TRHSLATISLEMERQKRDAQSRQEQDRSTVNALTS 1115
Query: 539 RNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVIL 598
+L + + + ++ L + +EE R+Q L +E+ R +
Sbjct: 1116 ELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQ-LRLLEDARDGLR 1174
Query: 599 NNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELE 658
L E ++K+++ + RE+ + A GE + E KE+E L N ++
Sbjct: 1175 RELLEAQRKLRE-----SQEGREVQRQEA---GELRRSLGEGAKEREALRRSNEELRSAV 1226
Query: 659 KNIVGEKTKEKVKLDAEREKLERLQELYS-------EQKTQLDNCPESMREQLQ--QQLK 709
K E+ K+ + + +KL L+E + E +T L S E + Q+L+
Sbjct: 1227 KKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELR 1286
Query: 710 RDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALK 769
R +LD E+ E +L+ L E E ++ RE ++ ++ + + ++
Sbjct: 1287 RQMKMLDSENTRL-GRELAELQGRLALGERAE---KESRRETLGLRQRLLKGEASLEVMR 1342
Query: 770 KQANHIVQQAQREQDHFVKEKNNLIMMLQREK 801
++ ++ Q ++ F + L+ L+ +
Sbjct: 1343 QELQVAQRKLQEQEGEFRTRERRLLGSLEEAR 1374
Score = 48.1 bits (113), Expect = 5e-05
Identities = 44/153 (28%), Positives = 74/153 (48%), Gaps = 7/153 (4%)
Query: 667 KEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDL- 725
K ++++ R + E Q+L + QL + ES R L++QL+R D D + ED
Sbjct: 530 KRQLQVQDMRGRYEASQDLLGTLRKQLSDS-ESERRALEEQLQRLRDKTDGAMQAHEDAQ 588
Query: 726 -EFQQLEHESRL-DEEKENLTQQLLREVAEYQ-RNIVSRKEKISALKKQANHIVQQAQRE 782
E Q+L + L EK NL L +VA+ Q + +EK+ A +++ + + E
Sbjct: 589 REVQRLRSANELLSREKSNLAHSL--QVAQQQAEELRQEREKLQAAQEELRRQRDRLEEE 646
Query: 783 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS 815
Q+ V++ + L+R L LE K S L+
Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLA 679
Score = 43.9 bits (102), Expect = 0.001
Identities = 155/774 (20%), Positives = 291/774 (37%), Gaps = 140/774 (18%)
Query: 373 SDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQ 432
S+++ TR + + S+E + ++ Q + +S++++++ +L D R Q
Sbjct: 1075 SEKLMGTRHSLATISLEMERQKRDA--------QSRQEQDRSTVNALTS--ELRDL-RAQ 1123
Query: 433 REERL--REQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSD 490
REE QE+ RL+ Q D + + + +++ +L L+ D
Sbjct: 1124 REEAAAAHAQEVRRLQEQAR-------------DLGKQRDSCLREAEELRTQLRLLE--D 1168
Query: 491 EESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRT 550
L+ + R ++ + G L +S R L R+
Sbjct: 1169 ARDGLRRELLEAQRKLRESQEGR--EVQRQEAGELRRSLGEGAKEREA--------LRRS 1218
Query: 551 PPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKD 610
S KA SE L + + E + Q+LA +EE R + EL+ +++
Sbjct: 1219 NEELRSAVKKAESERISLKL--------ANEDKEQKLALLEEARTAVGKEAGELRTGLQE 1270
Query: 611 INDQMDESFRELDMECALLDGEQKSETTELMKEKEILD----HLNRKIAELEKNI-VGEK 665
+ E+ REL EL ++ ++LD L R++AEL+ + +GE+
Sbjct: 1271 VERSRLEARRELQ---------------ELRRQMKMLDSENTRLGRELAELQGRLALGER 1315
Query: 666 TKEKVKLD--AEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFE 723
+++ + + R++L + + + +L ++EQ + R+ LL +
Sbjct: 1316 AEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLG-SLEEAR 1374
Query: 724 DLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQ 783
E QQL+H L+ + E E AE + + + + L+ + + Q + +
Sbjct: 1375 GTEKQQLDHARGLELKLE----AARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAE 1430
Query: 784 DHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGN 843
+ L L+R L + + P +P S +N P +
Sbjct: 1431 ----AQLGGLRSALRR------GLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSP--S 1478
Query: 844 STNLSPSTQFPADADAVATEPATAVL---ASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
+ SP +Q P+ AT PA+ L A + +E + L +++ E
Sbjct: 1479 TLECSPGSQPPSPGP--ATSPASPDLDPEAVRGALREFLQELRSAQRERDE--------- 1527
Query: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960
+ TS+++ + R +S S A+A+ E+RR + G
Sbjct: 1528 LRTQTSALNRQLAEMEAER-------------DSATSRARQLQKAVAESEEARRSVDGRL 1574
Query: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020
+E Q+ E R+ E L+ +L+ S S S
Sbjct: 1575 SGVQAELALQE-ESVRRSERERRATLD--------------QVATLERSLQATESELRAS 1619
Query: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR------- 1073
+ IS +N ++E +R LK E ESR ++E ++R+LE E +R
Sbjct: 1620 QEKISKMK-ANETKLEGDKRRLK----EVLDASESRTVKLELQRRSLEGELQRSRLGLSD 1674
Query: 1074 REILEKRLQEETSQRQKLI-EKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHV 1126
RE + LQ+ Q+ + + EVK Q R V + + LR V
Sbjct: 1675 REAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKV 1728
Score = 31.6 bits (70), Expect = 5.0
Identities = 34/168 (20%), Positives = 75/168 (44%), Gaps = 32/168 (19%)
Query: 568 LSILPKTPEGISEEQRSQELAAM--EETRIVILNNLEEL-KQKIKDINDQMDESFRELDM 624
L L + + E+R E +A+ E+ R+ + L+++ ++K++ D + L
Sbjct: 1847 LGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV-----RLSA 1901
Query: 625 ECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQE 684
E LD EL + + + L ++ LE++ + ++++DA++++LE QE
Sbjct: 1902 EKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQS----HSPAQLEVDAQQQQLELQQE 1957
Query: 685 LYSEQKTQ--------------------LDNCPESMREQLQQQLKRDA 712
+ + Q L+ +++ QLQQ+L+R +
Sbjct: 1958 VERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSS 2005
Score = 31.2 bits (69), Expect = 6.5
Identities = 20/49 (40%), Positives = 30/49 (61%), Gaps = 4/49 (8%)
Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEE 1084
+E+ERL + A A+ R LE+RER + R LEE+ L+ +LQ+E
Sbjct: 1956 QEVERL-RSAQAQTERTLEARERAHRQRVRGLEEQV---STLKGQLQQE 2000
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 65.9 bits (159), Expect = 2e-10
Identities = 157/749 (20%), Positives = 300/749 (40%), Gaps = 110/749 (14%)
Query: 395 LESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETIL 454
LE+L+Q + L+ K +I S + L+ +E L+EQ ERL Q LE I
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLT----SEKEALQEQLDERL--QELEKIK 334
Query: 455 SL-CAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDS 513
L AE TK ++L D + + ++LE+ ++ ++ +T+ + H
Sbjct: 335 DLHMAEKTKLITQL------RDAKNLIEQLEQ----------DKGMVIAETKRQMHETLE 378
Query: 514 LPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPK 573
+ + ++A S + +T+ +EL ++ KA S + +
Sbjct: 379 MKEEEIAQLRSRIKQM-------TTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431
Query: 574 TPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ 633
+ +EQ EE RI + L +KQ++ D+ + E + A L Q
Sbjct: 432 KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEE------QIAKL---Q 482
Query: 634 KSETTEL-MKEKEILDHL---NRKIAELEKNIVGEKTKEKVKLDAEREKLE--RLQELYS 687
K EL KE+E+ L R+ E K + + E +K+ E+E+ E L+EL
Sbjct: 483 KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELEL 542
Query: 688 EQKTQLDNCPESMREQLQQQLKRDADLLDVES---KHFEDLEFQQLEHESRLDEEKENLT 744
++K L +R+ Q+ +L++ES K ++ + Q + L+ EK
Sbjct: 543 QKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHN 602
Query: 745 QQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENL 804
+++ V +++ + S K + AL + +++Q + + ++EK ++EKE L
Sbjct: 603 KEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK------CEQEKETL 656
Query: 805 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEP 864
K + +N TL++ + E+ +LS A E
Sbjct: 657 L---KDKEIIFQAHIEEMNEKTLEKLDVKQTELE-------SLSSELSEVLKARHKLEEE 706
Query: 865 ATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPK 924
+ + + K+ + + +K H + ++ S I H S T K
Sbjct: 707 LSVLKDQTDKMKQELEAKMDEQKNHHQ----------QQVDSIIKEHEVSIQR----TEK 752
Query: 925 AHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASES-- 982
A Q N L + K+ + + + H + E ++SE + AS
Sbjct: 753 A--LKDQIN--------QLELLLKERD-KHLKEHQAHVENLEADIKRSEGELQQASAKLD 801
Query: 983 --NVYLNSFHYPDHSYKDQAFD----TLSLDSSDSMETSISACSPDNISSASTSNIARIE 1036
Y ++ H +Y++Q L L++ + T A T A
Sbjct: 802 VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKI 861
Query: 1037 EMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKE- 1095
+++ L++Q LE + EME K ++L + + LE +E+ +Q L+EKE
Sbjct: 862 QVQDLMQQ--------LEKQNSEMEQKVKSLTQVYESK--LEDGNKEQEQTKQILVEKEN 911
Query: 1096 --VKIRERQRAQARPLTRYLPVRKEDFDL 1122
+++RE Q+ + LT+ L +++ +
Sbjct: 912 MILQMREGQKKEIEILTQKLSAKEDSIHI 940
Score = 65.1 bits (157), Expect = 4e-10
Identities = 139/752 (18%), Positives = 299/752 (39%), Gaps = 99/752 (13%)
Query: 409 LRERKSSISSISGRDDLMDYHRRQREERLREQE--MERLERQRLETI--LSLCAEYTKPD 464
++ K+ I S+ + + +++ E+E + +L+++ E I ++L E K +
Sbjct: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELK-E 1364
Query: 465 SRLSTGTTVEDVQKINKELEK-LQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCG 523
++ + + + +N +L+ + LS++E+ D +C D + D
Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEE-KCELLDQVQDLSF-KVD 1422
Query: 524 SLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQR 583
+LS+ S + D+ + + S F + + L I E +
Sbjct: 1423 TLSKEKISALE----QVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI--------QLELK 1470
Query: 584 SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKE 643
S+E +E ++ L++ ++ + +M++ +++ + + L+ E KS+T +M
Sbjct: 1471 SKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM-- 1528
Query: 644 KEILDHLNRKIAELE------KNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP 697
E+ DH+ +K E+E KN +K E +L +KL+ QEL E+ ++
Sbjct: 1529 -ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKEL---VQKLQHFQELGEEKDNRVKEAE 1584
Query: 698 ESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRN 757
E + Q A+ L+ + K E + E L ++ L + ++AE +R
Sbjct: 1585 EKILTLENQVYSMKAE-LETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKR- 1642
Query: 758 IVSRKEKISALKKQANHIVQQAQREQDHFVK----EKNNLIMMLQREKENLCNLEKKYSS 813
++KI+A+KKQ ++ Q + +++ + K + L LQ + + LE+K S
Sbjct: 1643 --KAEQKIAAIKKQ---LLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKS 1697
Query: 814 LSGGKGFP-VNPNTLKE--GYISVNEI-NEPCGNST----------NLSPSTQFPADADA 859
+ + + P + K Y E ++ C T NL+ +
Sbjct: 1698 VESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ 1757
Query: 860 VATEPATAVLASQPQSKEHFRSLEERK-KQHKEGL---YLSDTL--PRKKTTSSISPHFS 913
E ++ + Q +E LE + KQH++ +L + L KK + ++ H
Sbjct: 1758 EKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVE 1817
Query: 914 SATMGRSITPKAHL---------PLGQSNSCGSVLPPSL----AAMAKDSESRRM----- 955
+I K +L L + +L + + + + E R+
Sbjct: 1818 KEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEEL 1877
Query: 956 ---LRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSM 1012
Q +G + +E E + H + + + +D +
Sbjct: 1878 TSKYEKLQALQQMDGRNKPTELLEENTEEKS--------KSHLVQPKLLSNMEAQHND-L 1928
Query: 1013 ETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLE---SREREMEAKKRALEE 1069
E ++ + I R+++ R+L++ H ++ +L+ +ERE + K+ +
Sbjct: 1929 EFKLAGAERE--KQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDL 1986
Query: 1070 EKRRREILEKRLQE-ETSQRQKLIEKEVKIRE 1100
E + L++ ++E T QK E E+ I+E
Sbjct: 1987 ELKHNSTLKQLMREFNTQLAQKEQELEMTIKE 2018
Score = 62.4 bits (150), Expect = 3e-09
Identities = 161/816 (19%), Positives = 322/816 (39%), Gaps = 120/816 (14%)
Query: 395 LESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLE--RQRLET 452
L+ L+Q T LRE+ +D + + + E + E+ +E+L+ + LE+
Sbjct: 631 LQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIF--QAHIEEMNEKTLEKLDVKQTELES 688
Query: 453 ILSLCAEYTKPDSRLSTGTTV--EDVQKINKELEKLQLSDEESVFEEALMS--PDTRYRC 508
+ S +E K +L +V + K+ +ELE ++ ++++ ++ + S +
Sbjct: 689 LSSELSEVLKARHKLEEELSVLKDQTDKMKQELEA-KMDEQKNHHQQQVDSIIKEHEVSI 747
Query: 509 HRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYL 568
R + + L + + L +D+ R+ K SY
Sbjct: 748 QRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQ 807
Query: 569 SILPKTPEGISEE--QRSQELAAMEETRIVILNNLEELKQKIKDI--------------- 611
S + + E+ Q Q+L +E RI++ + E++ + KD+
Sbjct: 808 SATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLM 867
Query: 612 ------NDQMDESFRELDM--ECALLDGEQKSETT-ELMKEKEIL------------DHL 650
N +M++ + L E L DG ++ E T +++ EKE + + L
Sbjct: 868 QQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEIL 927
Query: 651 NRKIAELEKNIV------------GEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPE 698
+K++ E +I EK EKVK A +E E L++ +Q+ +L E
Sbjct: 928 TQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKA-KEMQETLKKKLLDQEAKLKKELE 986
Query: 699 SMREQLQQQLKR-DADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRN 757
+ +L Q+ K+ +A +L++ + + E+ E+ E+LT+ RE+ + +
Sbjct: 987 NTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDV-IS 1045
Query: 758 IVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGG 817
I +K A + Q H +Q ++EQ+ V E I++ EKE + N E + G
Sbjct: 1046 IWEKKLNQQAEELQEIHEIQLQEKEQE--VAELKQKILLFGCEKEEM-NKEITWLKEEG- 1101
Query: 818 KGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKE 877
V +T ++NE+ E Q A +++A + + + K
Sbjct: 1102 ----VKQDT------TLNELQEQL---------KQKSAHVNSLAQD--------ETKLKA 1134
Query: 878 HFRSLE-ERKKQHKEGLYLSDTLPRKKTTSSISPH-FSSATMGRSITPKAHLPLGQSN-- 933
H LE + K KE +L + L K + S T T + L S+
Sbjct: 1135 HLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEK 1194
Query: 934 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPD 993
S S+ SL E L + + + +E N ++S++N L+ +
Sbjct: 1195 SNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQ 1254
Query: 994 HSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLL 1053
H + I C+ + + + ++ E + L + + T L
Sbjct: 1255 HR-----------TTKVKEALLIKTCTVSELE----AQLRQLTEEQNTLNISFQQATHQL 1299
Query: 1054 ESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYL 1113
E +E ++++ K +E +E L+K E +Q+Q EKE I + ++ + +
Sbjct: 1300 EEKENQIKSMKADIESLVTEKEALQK---EGGNQQQAASEKESCITQLKKELSENINAVT 1356
Query: 1114 PVRKEDFDLRSHVETAGH-----NIDTCYHVSITEK 1144
+++E + + + + N+ +S++EK
Sbjct: 1357 LMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392
Score = 56.6 bits (135), Expect = 1e-07
Identities = 81/431 (18%), Positives = 184/431 (42%), Gaps = 50/431 (11%)
Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 451
+A+LE+ ++ +++ ++ + ++ R + + +R EQ++ +++Q L
Sbjct: 1598 KAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLS 1657
Query: 452 TILSLCAEYTK-PDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHR 510
+ +Y K +S LS T ++ + + +L ES E L+ P +
Sbjct: 1658 QMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAA 1717
Query: 511 KDSLPDADLASCGSLS-QSSASFFTPRSTRNDELLSDLTRTPPPP-SSTFPKASSESSYL 568
+AD C + + S T ++LL + + SS F L
Sbjct: 1718 YTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERL 1777
Query: 569 --------------SILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQ 614
S++ E + E+ + L + N + KQ ++++ D
Sbjct: 1778 IKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDD 1837
Query: 615 MDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLD- 673
+ ++ +E ++ C +L+ +KI EL+ +V +K +V+++
Sbjct: 1838 VQKTLQEKELTCQILE---------------------QKIKELDSCLVRQKEVHRVEMEE 1876
Query: 674 --AEREKLERLQELYSEQK-TQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL 730
++ EKL+ LQ++ K T+L E+ E+ + L + L ++E++H DLEF+
Sbjct: 1877 LTSKYEKLQALQQMDGRNKPTEL--LEENTEEKSKSHLVQPKLLSNMEAQH-NDLEFKL- 1932
Query: 731 EHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQAN-HIVQQAQREQDHFVKE 789
+ + EK+ L ++++R + + ++++ LKK+ + ++ ++EQ+ +
Sbjct: 1933 ---AGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELK 1989
Query: 790 KNNLIMMLQRE 800
N+ + L RE
Sbjct: 1990 HNSTLKQLMRE 2000
Score = 55.8 bits (133), Expect = 2e-07
Identities = 115/621 (18%), Positives = 247/621 (39%), Gaps = 78/621 (12%)
Query: 574 TPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ 633
T + I E ++ L + + + L + Q +++ ++ D +E + + L+ +
Sbjct: 1535 TQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQV 1594
Query: 634 KSETTELMKEKEILDHLN-------RKIAELEKNIVGE--------KTKEKVKLDA-ERE 677
S EL +K+ L+H+N ++ LE + E K K + K+ A +++
Sbjct: 1595 YSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQ 1654
Query: 678 KLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL------E 731
L +++E + K ++ + +LQ++ +R+ +L+ + K E + + L +
Sbjct: 1655 LLSQMEEKEEQYKKGTESHLSELNTKLQER-EREVHILEEKLKSVESSQSETLIVPRSAK 1713
Query: 732 HESRLDEEKENLTQQLLREVAE-----YQRNIVSRKEKISALKKQ-----ANHIVQQAQR 781
+ + E++E +Q +++ E QRN+ +++ + + ++ ++H + Q
Sbjct: 1714 NVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY 1773
Query: 782 EQ-----DHFVKEKNNLIMMLQREKENLCNLEKKYSSL-------SGGKGFPVNPNTLKE 829
++ +H +++ M+ +E L KKYS + GGK L+
Sbjct: 1774 QERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLEN 1833
Query: 830 GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSK-EHFRSLEERKKQ 888
+ V + + + + D+ V + V + SK E ++L++ +
Sbjct: 1834 VFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGR 1893
Query: 889 HKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAK 948
+K L + K + + P S + + L + L + + K
Sbjct: 1894 NKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREK--QKLGKEIVRLQK 1951
Query: 949 DSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDS 1008
D RMLR + Q++ ++ + + L H + F+T
Sbjct: 1952 DL---RMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008
Query: 1009 SDSMETSISACSPDNISSASTSNIARIE----EMERLLKQAHAEK-----------TRLL 1053
+E +I + I+ A +E E +LLK+ AEK +L
Sbjct: 2009 EQELEMTIK----ETINKAQEVEAELLESHQEETNQLLKKI-AEKDDDLKRTAKRYEEIL 2063
Query: 1054 ESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYL 1113
++RE EM AK R L+ + E L+K+ Q++ Q + V I E Q A+ T
Sbjct: 2064 DAREEEMTAKVRDLQTQ---LEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLIS 2120
Query: 1114 PVRKEDFDLRSHVETAGHNID 1134
+ ++ + R + HN++
Sbjct: 2121 DSKLKEQEFREQI----HNLE 2137
Score = 51.6 bits (122), Expect = 5e-06
Identities = 92/449 (20%), Positives = 184/449 (40%), Gaps = 51/449 (11%)
Query: 391 DEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLR-EQEMERLERQR 449
+ A E L +A T Q R+ + + + + + EER+ +QE+ R++++
Sbjct: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMD--EQIKTIEKTSEEERISLQQELSRVKQEV 466
Query: 450 LETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCH 509
++ + E +L Q++ K+L+ + +E + + AL + Y
Sbjct: 467 VDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQM-KVALEKSQSEYLKI 525
Query: 510 RKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPP-------SSTFPKAS 562
++ LA Q A T ++ L DL + S+ K+
Sbjct: 526 SQEKEQQESLALEELELQKKAIL-----TESENKLRDLQQEAETYRTRILELESSLEKSL 580
Query: 563 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELK-----QKIKDINDQMDE 617
E+ S + + ++E+ M E L +L+ + +K++ + Q
Sbjct: 581 QENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQT 640
Query: 618 SFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAERE 677
+L +C EQ+ ET L+K+KEI+ A +E+ + EKT EK LD ++
Sbjct: 641 EMEKLREKC-----EQEKET--LLKDKEIIFQ-----AHIEE--MNEKTLEK--LDVKQT 684
Query: 678 KLERLQELYSEQKTQLDNCPESMR------EQLQQQLKRDADLLDVESKHFEDLEFQQLE 731
+LE L SE E + ++++Q+L+ D + ++ H + ++ E
Sbjct: 685 ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMD--EQKNHHQQQVDSIIKE 742
Query: 732 HESRLDEEKENLTQQ------LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDH 785
HE + ++ L Q LL+E ++ + + E + A K++ +QQA + D
Sbjct: 743 HEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDV 802
Query: 786 FVKEKNNLIMMLQREKENLCNLEKKYSSL 814
F ++ + +E L L++K L
Sbjct: 803 FQSYQSATHEQTKAYEEQLAQLQQKLLDL 831
Score = 47.0 bits (110), Expect = 1e-04
Identities = 115/532 (21%), Positives = 216/532 (40%), Gaps = 62/532 (11%)
Query: 602 EELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMK-EKEILDHLNRKIAELEKN 660
+ L+ K + +E +LD+ C + +++T EL+ + + +I+ +
Sbjct: 1197 KSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHR 1256
Query: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
K +K E +L++L EQ T + ++ + +++ + + D+ES
Sbjct: 1257 TTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESL 1316
Query: 721 HFEDLEFQQLE-HESRLDEEKENLTQQLLREVAE-------YQRNIVSRKEKISALKKQA 772
E Q+ ++ + EKE+ QL +E++E + + +K +IS+L KQ
Sbjct: 1317 VTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQL 1376
Query: 773 NHIVQQAQREQDHFVKEKNNLIMMLQRE-KENLCNLEKKYSSLSGGKGFPVNPNTLKEGY 831
+ Q Q + EK I L+++ E C L + LS F V+ TL +
Sbjct: 1377 TDLNVQLQNSIS--LSEKEAAISSLRKQYDEEKCELLDQVQDLS----FKVD--TLSKEK 1428
Query: 832 ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQ----SKEHFRS------ 881
IS E + N + ++ A + T+ V Q Q SKE +
Sbjct: 1429 ISALEQVDDWSNKFS-----EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINL 1483
Query: 882 -LEERKKQHK-----EGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLG--QSN 933
EE +Q+K +G D +K S++ S T R + + H+ +
Sbjct: 1484 LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQT-ARIMELEDHITQKTIEIE 1542
Query: 934 SCGSVLPPSLAAMAKDSESRRMLRGYNH-QQMSE--GHRQKSEFYNRTASESNVYLNSFH 990
S VL KD E + +++ H Q++ E +R K E+ VY
Sbjct: 1543 SLNEVLKNY--NQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMK-- 1598
Query: 991 YPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM---------ERL 1041
+ K + + ++L S S E + A D + S S + +A ++ ++L
Sbjct: 1599 -AELETKKKELEHVNL-SVKSKEEELKALE-DRLESESAAKLAELKRKAEQKIAAIKKQL 1655
Query: 1042 LKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQE-ETSQRQKLI 1092
L Q ++ + + E + L+E +R ILE++L+ E+SQ + LI
Sbjct: 1656 LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLI 1707
Score = 45.8 bits (107), Expect = 3e-04
Identities = 139/739 (18%), Positives = 275/739 (37%), Gaps = 89/739 (12%)
Query: 428 YHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQ 487
+ +E +R E L R L+ S A + P S ED+ + L K Q
Sbjct: 85 FRSSSKESLVRTSSRESLNRLDLD---SSTASFDPPSDMDSEA---EDLVGNSDSLNKEQ 138
Query: 488 LSDEESVFEEALMSPDTRYR--CHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLS 545
L E +L S +Y L G LSQS + +EL
Sbjct: 139 LIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQM 198
Query: 546 DLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELK 605
D + Y+S+L + + R+ + + +L L +L+
Sbjct: 199 DQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPM------NVDVLKPLPQLE 252
Query: 606 QKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN----- 660
+ + + + E D E + DG L + + ++L ++ E ++
Sbjct: 253 PQAEVFTKEENP---ESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQC 309
Query: 661 --IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVE 718
+ EK + +LD ++LE++++L+ +KT+L + L +QL++D ++ E
Sbjct: 310 TLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAK-NLIEQLEQDKGMVIAE 368
Query: 719 SKH--FEDLEFQQLEHESRLDEEKENLTQ--QLLREVAEYQRNIVSRKEKISALKKQANH 774
+K E LE ++ E K+ TQ +L + + +R EK + ++
Sbjct: 369 TKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEE 428
Query: 775 IVQQAQREQDHFVK--------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNT 826
++ + E D +K E+ +L L R K+ + ++ KK S
Sbjct: 429 ARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS-------------- 474
Query: 827 LKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERK 886
+E + +++E + E + + +S+ + + + K
Sbjct: 475 -EEQIAKLQKLHE----KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEK 529
Query: 887 KQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAM 946
+Q +E L L + +KK + S R + +A + S L SL
Sbjct: 530 EQ-QESLALEELELQKKAILT-----ESENKLRDLQQEAETYRTRILELESSLEKSLQEN 583
Query: 947 AKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSL 1006
S+ L + + ++ +++ + + +E L S + + + L
Sbjct: 584 KNQSKD---LAVHLEAEKNKHNKEITVMVEKHKTE----LESLKHQQDALWTEKLQVLKQ 636
Query: 1007 DSSDSMETSISACSPDNISSASTSNI---ARIEEM-ERLLKQAHAEKTRL--LESREREM 1060
ME C + + I A IEEM E+ L++ ++T L L S E+
Sbjct: 637 QYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEV 696
Query: 1061 EAKKRALEEE--------KRRREILEKRLQEETSQRQKLI-----EKEVKIRERQRAQAR 1107
+ LEEE + ++ LE ++ E+ + Q+ + E EV I+ ++A
Sbjct: 697 LKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKD 756
Query: 1108 PLTRY-LPVRKEDFDLRSH 1125
+ + L +++ D L+ H
Sbjct: 757 QINQLELLLKERDKHLKEH 775
Score = 45.8 bits (107), Expect = 3e-04
Identities = 46/194 (23%), Positives = 93/194 (47%), Gaps = 13/194 (6%)
Query: 568 LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMEC- 626
L IL K + EE+ QE +E L + LKQ +++ N Q+ + +EL+M
Sbjct: 1964 LEILKKEYDQEREEKIKQEQEDLE------LKHNSTLKQLMREFNTQLAQKEQELEMTIK 2017
Query: 627 ALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDA-EREKLERLQEL 685
++ Q+ E L +E + L +KIAE + ++ + + LDA E E ++++L
Sbjct: 2018 ETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDL 2077
Query: 686 YSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEK-ENLT 744
+TQL+ + +++L+Q+ D + + + + L +S+L E++
Sbjct: 2078 ----QTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQI 2133
Query: 745 QQLLREVAEYQRNI 758
L + +Y++N+
Sbjct: 2134 HNLEDRLKKYEKNV 2147
>gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
Length = 1154
Score = 65.9 bits (159), Expect = 2e-10
Identities = 172/818 (21%), Positives = 312/818 (38%), Gaps = 138/818 (16%)
Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 451
+A+++SLRQA+ + + E +S I+S+ ++DL R Q E ++MER+
Sbjct: 147 QAEIQSLRQAA---EDSATEHESDIASL--QEDLC---RMQNEL----EDMERIRGDYEM 194
Query: 452 TILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQ-----LSDEESVFEEALMS----- 501
I SL AE S S + D + +EL++L+ L++E +E+ S
Sbjct: 195 EIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQL 254
Query: 502 ---PDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTF 558
R + + L L+ + SQ+S F L L
Sbjct: 255 ADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMK 314
Query: 559 PKASSESSYLSILPKTPEGISEEQR---------SQELAAMEETRIVILNNLEELKQKI- 608
K L L + EEQR E+ + + V N EELK ++
Sbjct: 315 NKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQN--EELKSRLC 372
Query: 609 ---KDINDQMDESFRELDMECALLDGEQ-----KSETTELMKEKEILDHLNRKIAELEKN 660
K + DE L M+ L + KS E EKE+L L +K+ +N
Sbjct: 373 TLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRL-QKLHLQHQN 431
Query: 661 IVGEKTKEKVKLDAEREKLE----RLQELYS-----EQKTQLDNCPESMREQLQQQLKRD 711
+ EK K + +E+L+ LQ L ++ + D + ++++Q +
Sbjct: 432 VTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQAS 491
Query: 712 ADLLDVESKHFED----------LEFQQLEHESRLDEEK---ENLTQQLLREVAEYQRNI 758
D L+ KH D LE ++L+ + E+K N LL + E Q
Sbjct: 492 KDELE-RQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKY 550
Query: 759 VSRKEKISALKKQANHIVQQAQR---EQDHFVKEKNNLIMMLQR------------EKEN 803
+ ++++ L+ + +++ +R EQ +E + L + L + + E+
Sbjct: 551 KASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLED 610
Query: 804 LCNLEKKYSSLSGG-KGFPVNPNTLKEGYISVNE----INEPCGNSTNLSPSTQFPADAD 858
LC L+ Y + K N + + + + ++E E +P A +
Sbjct: 611 LCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSS 670
Query: 859 AVATEPATAVLASQPQSKEHFRSLEERKK---QHKEGLYLSDTLPRKKTTSSISPHFSSA 915
+ +L Q Q+ + + K+ Q ++G L + RK+ + +
Sbjct: 671 KCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEE---RKRLQADLQLCLEEM 727
Query: 916 TMGRSITPKAHLPL-GQSNSCGSVLPPS------LAAMAKDSESRRMLRGYNHQQMSEGH 968
+ + +P + L S GS++P + D+ES + Y Q S
Sbjct: 728 QLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNES--YYKSYTSTQTSSKS 785
Query: 969 RQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSAS 1028
KS Y+ + S S Y S+ +S +++ S +S C +SS +
Sbjct: 786 FLKS--YDSSTSASEAYGKSYCTTSNS-------SITYKKSYGSTSSSDTCQKSFVSSCT 836
Query: 1029 TSNIARIEEMERL----------------LKQAHAEKTRLLESREREMEAKKRALEEE-- 1070
A E+MER + Q E+ L+ + ++ AK++ L+EE
Sbjct: 837 DEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELD 896
Query: 1071 ------KRRREILEKRLQEETSQRQKLIEKEVKIRERQ 1102
K E LEK + + + + ++ E + K+RE Q
Sbjct: 897 ACEREFKECMECLEKPMAPQ-NDKNEIKELQTKLRELQ 933
Score = 38.5 bits (88), Expect = 0.041
Identities = 67/291 (23%), Positives = 117/291 (40%), Gaps = 32/291 (10%)
Query: 428 YHRRQREERLREQEMERL--ERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEK 485
Y Q ++ L +QE RL ER+RL+ L LC +E++Q + +
Sbjct: 692 YDAGQAKQELLQQEQGRLLEERKRLQADLQLC---------------LEEMQLLQVQSPS 736
Query: 486 LQLSDEESVFEEALMSPDTRYRCHRKDSLPDAD---LASCGSLSQSSASFFT--PRSTRN 540
+++S E M P D+ D + S S SS SF ST
Sbjct: 737 IKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSA 796
Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
E T S T+ K+ +S K+ ++ E ME +++
Sbjct: 797 SEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKV 856
Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL----MKEKEILDHLNRKIA- 655
L +L Q ++ + E +L + L +QK EL + KE ++ L + +A
Sbjct: 857 LIKL-QAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAP 915
Query: 656 ELEKNIVGE---KTKE-KVKLDAEREKLERLQELYSEQKTQLDNCPESMRE 702
+ +KN + E K +E +++ A ++ RL + + + QL C E +R+
Sbjct: 916 QNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQ 966
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 65.5 bits (158), Expect = 3e-10
Identities = 156/764 (20%), Positives = 300/764 (39%), Gaps = 108/764 (14%)
Query: 386 GSVEFDEADLESLRQASGTPQPA---LRERKSSISSISGR--DDLMDYHRRQREERLREQ 440
G V A+L+SL Q Q +++ K + + ++ D + EER +
Sbjct: 128 GLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE 187
Query: 441 EMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 500
E+ + E + + L +EDV + KEL ++Q LM
Sbjct: 188 AAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQ----------TLM 237
Query: 501 SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPK 560
T R + L D C L AS S +L S+L + P + +
Sbjct: 238 DNMTLERERESEKLKD----ECKKLQSQYASSEATIS----QLRSELAKGPQEVAVYVQE 289
Query: 561 ASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFR 620
S ++ L + + ++E +E + T++ +N E + +K + +
Sbjct: 290 LQKLKSSVNELTQKNQTLTENLLKKE---QDYTKLEEKHNEESVSKK------NIQATLH 340
Query: 621 ELDMECALLDGEQKSETT-------ELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLD 673
+ D++C L + T EL ++ E L +++E+E K + K +L
Sbjct: 341 QKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFK-QLQ 399
Query: 674 AEREKLER--------LQELYS---EQKTQLDNCPESMREQLQQQLKRDADLLDVESKHF 722
+RE+ E+ + +L+S E + QL ++EQ Q ++ L+D E +
Sbjct: 400 QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEK---LMDKEQQ-V 455
Query: 723 EDLEFQQLEHESRLDEEKENLT--QQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
DL+ + E +L E+ N T Q L + + + + ++ +A ++A + ++Q
Sbjct: 456 ADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVL 515
Query: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKK----YSSLSGGKGFPVNPNTLKEGYISVNE 836
R+ ++ NL +LQ+ KEN+ LEK+ Y+ + G+G N L+E ++ E
Sbjct: 516 RQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQE 575
Query: 837 INEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEER----------- 885
T L+ + +++ A E + Q K H R+ ++R
Sbjct: 576 ------QVTQLTEKLKNQSESHKQAQENLHDQVQEQ---KAHLRAAQDRVLSLETSVNEL 626
Query: 886 ---KKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPS 942
+ KE + D + KT +S +A + + HL Q+
Sbjct: 627 NSQLNESKEKVSQLDIQIKAKTELLLSA--EAAKTAQRADLQNHLDTAQN---------- 674
Query: 943 LAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFD 1002
A K E ++ + Q++ + K E ++ S Y + + ++
Sbjct: 675 -ALQDKQQELNKITTQLD--QVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQ 731
Query: 1003 TLSLDSSDSMETSIS-ACSPDNISSASTSNIARIEEMERLLKQAHAEK-----TRL-LES 1055
L+ +DS+E S + ++ N L KQ EK TRL L+
Sbjct: 732 IKKLE-ADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQK 790
Query: 1056 REREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIR 1099
+ +E+ K+ L +++ ++IL++ E SQ K+ +E+ R
Sbjct: 791 KSEALESIKQKLTKQEEEKQILKQDF-ETLSQETKIQHEELNNR 833
Score = 65.5 bits (158), Expect = 3e-10
Identities = 142/703 (20%), Positives = 277/703 (39%), Gaps = 111/703 (15%)
Query: 431 RQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQ-KINKELEKL-QL 488
+Q +E L +Q E+ R D LS T+V ++ ++N+ EK+ QL
Sbjct: 592 KQAQENLHDQVQEQKAHLR-----------AAQDRVLSLETSVNELNSQLNESKEKVSQL 640
Query: 489 SDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLT 548
+ E L+S + R D D A + Q +T+ D++ + L
Sbjct: 641 DIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQ--NALQDKQQELNKITTQLDQVTAKLQ 698
Query: 549 RTPPPPSSTFPKASS-ESSYLSILPKTPEGISE----EQRSQELAAMEETRIVILNNLEE 603
S + YLS+ KT E + E S E+ A +E L +L++
Sbjct: 699 DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA---LQDLQQ 755
Query: 604 LKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVG 663
+Q D+ + E ++L+ME ++ S +L K+ E L+ + +K+
Sbjct: 756 QRQLNTDLELRATELSKQLEMEKEIVS----STRLDLQKKSEALESIKQKL--------- 802
Query: 664 EKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFE 723
TK++ + ++ E L + Q +L+N ++ +LQ+ +K + + L E
Sbjct: 803 --TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK-VKMEKEALMTEL---- 855
Query: 724 DLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQ 783
S + ++ ++ L +E+++ K I L+K + Q Q +
Sbjct: 856 ----------STVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM 905
Query: 784 DHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGN 843
++ +KE+ L L++EKE L+ + +S+ + NTLK+ + E + GN
Sbjct: 906 ENTLKEQKELKKSLEKEKEASHQLKLELNSMQ--EQLIQAQNTLKQ---NEKEEQQLQGN 960
Query: 844 STNLSPST-QFPADADAVATEPATAVL---------------ASQPQSKE---------H 878
L S+ Q +A+ E AVL A+Q + E +
Sbjct: 961 INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
Query: 879 FRSLEERKKQHKEGLY--LSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCG 936
+ +E KQ + Y S+ L ++ S+ S + + +G N
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLS---LAQEDLISNRNQIGNQNKLI 1077
Query: 937 SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSY 996
L + A + +DS + QQ+ E + + + + +N
Sbjct: 1078 QELKTAKATLEQDSAKK-------EQQLQERCKALQDIQKEKSLKEKELVNE-------- 1122
Query: 997 KDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESR 1056
K + + + E + + S I +++ ++LL Q E
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE-------L 1175
Query: 1057 EREMEAKKRALEEEKRRREILEKRL-QEETSQRQKLIEKEVKI 1098
+ + ++ K A+E+EKR ++IL+ ++ +EE +++ IEKE K+
Sbjct: 1176 QGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKL 1218
Score = 60.1 bits (144), Expect = 1e-08
Identities = 94/447 (21%), Positives = 194/447 (43%), Gaps = 45/447 (10%)
Query: 396 ESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLERQ-RLET 452
ES +QA ++E+K+ + + R ++ + +L E +++ +L+ Q + +T
Sbjct: 589 ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKT 648
Query: 453 ILSLCAEYTKPDSR------LSTGTTV-----EDVQKINKELEKL--QLSDEE---SVFE 496
L L AE K R L T +++ KI +L+++ +L D++ S E
Sbjct: 649 ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLE 708
Query: 497 EALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSS 556
L +Y SL G + + A ++++ ++ L DL + +
Sbjct: 709 SHLKEYKEKYL-----SLEQKTEELEGQIKKLEADSLEVKASK-EQALQDLQQQRQLNTD 762
Query: 557 TFPKASSESSYLSI-----------LPKTPEGISEEQRSQELAAMEETRIVILNNLEELK 605
+A+ S L + L K E + E Q+L EE + ++ + E L
Sbjct: 763 LELRATELSKQLEMEKEIVSSTRLDLQKKSEAL--ESIKQKLTKQEEEKQILKQDFETLS 820
Query: 606 QKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEK 665
Q+ K +++++ + E + E+++ TEL K+ L K+++ KN E
Sbjct: 821 QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS----KVSDSLKNSKSEF 876
Query: 666 TKEKVKLDAEREKLERL-QELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFED 724
KE K A LE+ +EL + + Q++N + +E L++ L+++ +
Sbjct: 877 EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE-LKKSLEKEKEASHQLKLELNS 935
Query: 725 LEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQD 784
++ Q ++ ++ L ++ E QQL + E +++ +K++I AL+ + V Q ++
Sbjct: 936 MQEQLIQAQNTL-KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN 994
Query: 785 HFVKEKNNLIMMLQREKENLCNLEKKY 811
++ L EKE + L+ Y
Sbjct: 995 KLQQQLTQAAQELAAEKEKISVLQNNY 1021
Score = 54.3 bits (129), Expect = 7e-07
Identities = 106/537 (19%), Positives = 219/537 (40%), Gaps = 60/537 (11%)
Query: 393 ADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE------ERLREQEMERLE 446
A L+ ++ + L+E K S+ + + ++ ++ E + +EQ ++ L+
Sbjct: 695 AKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQ 754
Query: 447 RQR-LETILSLCAEYTKPDSRLS---TGTTVEDVQKINKELEKLQLS-----DEESVFEE 497
+QR L T L L A + +T D+QK ++ LE ++ +E+ + ++
Sbjct: 755 QQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQ 814
Query: 498 AL--MSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPS 555
+S +T+ + ++ + + + T ST D+L S ++ +
Sbjct: 815 DFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL-SKVSDSLKNSK 873
Query: 556 STFPKASSESSYLSI-LPKTPEGISEEQRSQELAAMEETRIVILNNLE-------ELKQK 607
S F K + + + L KT + + + + Q ++E + + +LE +LK +
Sbjct: 874 SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK-ELKKSLEKEKEASHQLKLE 932
Query: 608 IKDINDQM---DESFRELDMECALLDG---EQKSETTELMKEKEILDHLNRKIAELEKNI 661
+ + +Q+ + ++ + E L G E K + + K+ E L KIA L+K
Sbjct: 933 LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG-ELKIAVLQKTE 991
Query: 662 VGEKTKEKV-----KLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLD 716
+ K ++++ +L AE+EK+ LQ Y + + + + L DL
Sbjct: 992 LENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKS 1051
Query: 717 VESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIV 776
VE K L + L + L Q+L A +++ +++++ K I
Sbjct: 1052 VEEK--LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQ 1109
Query: 777 QQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNE 836
++ ++ V EK+ L + +E C EK+ + L N S+ E
Sbjct: 1110 KEKSLKEKELVNEKSKLAEI----EEIKCRQEKEITKL--------NEELKSHKLESIKE 1157
Query: 837 INEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGL 893
I TNL + Q A ++ A+ Q K + + L+++ K+ +E L
Sbjct: 1158 I-------TNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL 1207
Score = 53.9 bits (128), Expect = 9e-07
Identities = 52/207 (25%), Positives = 102/207 (49%), Gaps = 23/207 (11%)
Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
++ELK + + ++L C L QK ++ +KEKE+++ + K+AE+E+
Sbjct: 1077 IQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKS---LKEKELVNEKS-KLAEIEE- 1131
Query: 661 IVGEKTKEKVKLDAERE--KLERLQELYS---------EQKTQLDNCPESMREQLQQQLK 709
I + KE KL+ E + KLE ++E+ + +QK +L +S++ ++Q+ +
Sbjct: 1132 IKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKR 1191
Query: 710 RDADLLDVESKHFEDLEFQQLEHESRLD---EEKENLTQQLLREVAEYQRNIVSRKEKIS 766
L D K E+L+ + +E E++L +EKE ++ A+ I + E +
Sbjct: 1192 NQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLG 1251
Query: 767 ALKKQANHIVQQAQREQDHFVKEKNNL 793
+KK+ Q +QR K+ ++L
Sbjct: 1252 TVKKE----WQSSQRRVSELEKQTDDL 1274
Score = 50.1 bits (118), Expect = 1e-05
Identities = 128/710 (18%), Positives = 269/710 (37%), Gaps = 78/710 (10%)
Query: 474 EDVQKINKELEKLQLS-DEESVFEEALMSPDTRYR-CHRKDSLPDADLASCGSLSQSSAS 531
+DV + +E++ LQ S EE + E L +Y+ ++++ PD + + QS
Sbjct: 83 DDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQ 142
Query: 532 FFTPRSTRNDEL--LSDLTRTPPPPSSTF-----PKASSESSYLSILPKTPEGISEEQRS 584
T N + + DL +T K E S + ++EE
Sbjct: 143 QLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNK 202
Query: 585 QELAAME-ETRIVILNNLEE---LKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640
+ + +T ++ +E+ LK+++ + MD E + E L E K ++
Sbjct: 203 EATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQY 262
Query: 641 MKEKEILDHLNRKIAELEKNI---VGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP 697
+ + L ++A+ + + V E K K ++ +K + L E +++
Sbjct: 263 ASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLE 322
Query: 698 ESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDE-----------EKENLTQQ 746
E E+ + A L H +DL+ QQL+ E EK TQ+
Sbjct: 323 EKHNEESVSKKNIQATL------HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK 376
Query: 747 LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCN 806
L E++E + K LK + + QQ + ++ H ++ ++ + + + E
Sbjct: 377 LKEELSEVET-------KYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ 429
Query: 807 LEKKYSSLSGGKGFPVNPNTLKEGYIS---------VNEINEPCGNSTNLS----PSTQF 853
L + + L + KE ++ ++ E NST L + Q
Sbjct: 430 LGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ 489
Query: 854 PADADAVATEPATAVLASQPQSKEHFRSL--EERKKQHKEGLYLSDTLPRKKTTSSISPH 911
+ A+ + +Q ++ R + +++K Q+ E L
Sbjct: 490 HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDL 549
Query: 912 FSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQK 971
++ G T + ++++ + + SES + + H Q+ E
Sbjct: 550 YAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHL 609
Query: 972 SEFYNRTAS-ESNVYLNSFHYPDHSYKDQAFD------TLSLDSSDSMETSISACSPDNI 1024
+R S E++V + + K D T L S+++ +T+ A +++
Sbjct: 610 RAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHL 669
Query: 1025 SSASTSNIARIEEMERLLKQAHAEKTRL---------LESREREMEAKKRALEEEKRRRE 1075
+A + + +E+ ++ Q +L LES +E + K +LE++ E
Sbjct: 670 DTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELE 729
Query: 1076 ILEKRLQEETSQRQKLIEKEVKIRERQR-------AQARPLTRYLPVRKE 1118
K+L+ ++ + + E+ ++ ++QR +A L++ L + KE
Sbjct: 730 GQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKE 779
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 65.1 bits (157), Expect = 4e-10
Identities = 117/562 (20%), Positives = 238/562 (42%), Gaps = 59/562 (10%)
Query: 584 SQELAAMEETRIVILNNLEELKQKIKDINDQ---MDESFRELDMECALLDGEQKSETTEL 640
S A + +T+ +++L+ +D+ D+ ++ + +L+ E L +SE +
Sbjct: 575 SDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDR 634
Query: 641 MKEKEILDHLNRKIAELEKNIV-GEKTKEKVKLDAEREKLERLQELYSEQKT-------Q 692
EI++ L +I LE+++ G+ KV+L+ +R+ ER +L E+ Q
Sbjct: 635 THGSEIINDLQGRICGLEEDLKNGKILLAKVELE-KRQLQERFTDLEKEKSNMEIDMTYQ 693
Query: 693 LDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVA 752
L +S+ ++ + A L D ++K +E +E + + E+ + EK+ L ++ L++
Sbjct: 694 LKVIQQSLEQEEAEHKATKARLAD-KNKIYESIE--EAKSEAMKEMEKKLLEERTLKQKV 750
Query: 753 EYQRNIVSRKEKISALK----KQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 808
E N++ EK +L KQ+ + + +++D ++ NL + +++E + C +
Sbjct: 751 E---NLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQ 807
Query: 809 KKYSSLSGGKGFPVNPNTLKEGYISVN-EINEPCGNSTNLSPST----QFPADADAVATE 863
+ NTLK + E N NL + DAD E
Sbjct: 808 NDLKMQTQ------QVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKE 861
Query: 864 PATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITP 923
+ A Q S + + E K++ +E L L +KK +A + ++T
Sbjct: 862 LQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTK 921
Query: 924 KAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTAS--- 980
L +S + D E ++++ ++M H+Q+ + T +
Sbjct: 922 ADSEQLARSIA---------EEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLE 972
Query: 981 ESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-- 1038
E+N L S + K++ + L ++ +S + IS+A+ A+ E+
Sbjct: 973 ETNRTLTSDVANLANEKEELNNKLK-----DVQEQLSRLKDEEISAAAIK--AQFEKQLL 1025
Query: 1039 -ERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEET-SQRQKLIEKEV 1096
ER LK K + +R+ E KR + + RR+E ++L E S+R+KL ++ +
Sbjct: 1026 TERTLKTQAVNKLAEIMNRK---EPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMI 1082
Query: 1097 KIRERQRAQARPLTRYLPVRKE 1118
K ++ + +R E
Sbjct: 1083 KYQKELNEMQAQIAEESQIRIE 1104
Score = 52.0 bits (123), Expect = 4e-06
Identities = 67/277 (24%), Positives = 119/277 (42%), Gaps = 34/277 (12%)
Query: 564 ESSYLSILPKTPEGISEEQRSQE--------LAAMEETRIVILNNLEELKQKIKDINDQM 615
E+ LS P E S + R E L +EE + EEL+QK K +N ++
Sbjct: 418 ENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRL 477
Query: 616 DESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAE 675
+++ +EL+ E L + S +L +EK +L H N + + +K + +++
Sbjct: 478 EKTAKELEEEITLRKSVE-SALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSL 536
Query: 676 REKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDL---------E 726
+++LE L +++ Q QLQ+QL LL ES L +
Sbjct: 537 KDQLEDL-----KKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQ 591
Query: 727 FQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ-----R 781
QQLE +R ++K L + ++ + N+ S E + + I+ Q
Sbjct: 592 IQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGL 651
Query: 782 EQDHFVKEKNNLIMMLQREK----ENLCNLEKKYSSL 814
E+D +K L+ ++ EK E +LEK+ S++
Sbjct: 652 EED--LKNGKILLAKVELEKRQLQERFTDLEKEKSNM 686
Score = 43.9 bits (102), Expect = 0.001
Identities = 59/264 (22%), Positives = 120/264 (45%), Gaps = 31/264 (11%)
Query: 578 ISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSET 637
+SE+Q QE + E ++ + EL+++ +D + QM E +L+ E K++
Sbjct: 822 MSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAE-QYFSTLYKTQV 880
Query: 638 TELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLD-----AEREKL------ERLQELY 686
EL +E E L +++ + ++ + E+ +L+ A+ E+L E+ +L
Sbjct: 881 RELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLE 940
Query: 687 SEQKTQLDNCPESMREQLQQQLKRDADLLDVE------SKHFEDLEFQQLEHESRLDEEK 740
E+ + E M Q+ ++DA + +E + +L ++ E ++L + +
Sbjct: 941 KEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQ 1000
Query: 741 ENLTQQLLREV------AEYQRNIVS-RKEKISALKKQAN--HIVQQAQREQDHFV---- 787
E L++ E+ A++++ +++ R K A+ K A + + +R D V
Sbjct: 1001 EQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKE 1060
Query: 788 KEKNNLIMMLQREKENLCNLEKKY 811
KE L M L+ E+E L KY
Sbjct: 1061 KENRKLHMELKSEREKLTQQMIKY 1084
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 65.1 bits (157), Expect = 4e-10
Identities = 158/761 (20%), Positives = 311/761 (40%), Gaps = 112/761 (14%)
Query: 406 QPALRERKSSISS----ISGRDDLMDYHRRQREE---RLREQEM-----ERLERQRLETI 453
Q + E + S+S I DL H + +EE EQE+ E E Q
Sbjct: 1248 QETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNE 1307
Query: 454 LSLCAEYTKPDSRLSTGTTVEDVQKINKEL-EKLQLSDEE-----------SVFEEALMS 501
L L E S TT+ ++ L EK Q S EE +EAL
Sbjct: 1308 LELLTE----QSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEV 1363
Query: 502 PDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKA 561
+ + H +++L A + S + S + + +++S++ + P S+ +
Sbjct: 1364 KHDQLKEHIRETL--AKIQESQSKQEQSLNM-KEKDNETTKIVSEMEQFKPKDSALL-RI 1419
Query: 562 SSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRE 621
E LS + + E + A E+ ++L+ L++ ++ +DQ+ E+ +E
Sbjct: 1420 EIEMLGLS------KRLQESHDEMKSVAKEK------DDLQRLQEVLQSESDQLKENIKE 1467
Query: 622 LDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLE- 680
+ + + E K L +++E ++ L ++E E I T +K +L+A +KL+
Sbjct: 1468 IVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEI---STIQK-QLEAINDKLQN 1523
Query: 681 RLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEK 740
++QE+Y E++ Q + S ++ +LK+ + + + +E + LE +RL E +
Sbjct: 1524 KIQEIY-EKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQ 1582
Query: 741 ENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE 800
E + Q +++E E +R + + + LK+ IV + + Q+ KE L M E
Sbjct: 1583 EEI-QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQE---KEYQFLKMTAVNE 1638
Query: 801 -KENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADA 859
+E +C +E K +N ++ I + +I NL + D
Sbjct: 1639 TQEKMCEIEHLKEQFETQK---LNLENIETENIRLTQILH-----ENLEEMRSVTKERDD 1690
Query: 860 VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYL--------SDTLPR-----KKTTS 906
+ + T + + Q KE+ R R + +E L + +T+ + + T+
Sbjct: 1691 LRSVEET-LKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTN 1749
Query: 907 SIS------PHFSSATMGRSITPK-----AHLPLGQSNSCGSVL-------PPSLAAMAK 948
IS H + A + + + AH+ L + L L+ M K
Sbjct: 1750 EISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQK 1809
Query: 949 DSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDS 1008
D E+ Q++ Q + +E+ ++ KDQ +L+L
Sbjct: 1810 DLENSNAKLQEKIQELKANEHQLITL-KKDVNETQKKVSEMEQLKKQIKDQ---SLTLSK 1865
Query: 1009 SDSMETSISACSPDNISSAST-----SNIARIEEMERLLKQAHAEKTRLLESREREMEAK 1063
+ +++ +N+ + N+ R+EE +L E+ +L ES + E +A+
Sbjct: 1866 LEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKL------ERDQLKESLQ-ETKAR 1918
Query: 1064 KRALEEEKRRREILEKRLQEETSQ-RQKLIEKEVKIRERQR 1103
+++E + +L K +E + R+K+ EK ++I + Q+
Sbjct: 1919 DLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQK 1959
Score = 58.5 bits (140), Expect = 4e-08
Identities = 116/550 (21%), Positives = 228/550 (41%), Gaps = 74/550 (13%)
Query: 592 ETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLD--GEQKSETTELM---KEKEI 646
+T+ + N LE LKQ + IN + E+ + + GE K E + M +K+
Sbjct: 961 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD 1020
Query: 647 LDHLNRKI--AELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQL-----DNCPES 699
L+ N + A+++ N + E+ ++ L E+ +L+++ E +K QL +N +
Sbjct: 1021 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT 1080
Query: 700 MREQ-----LQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEY 754
+ Q L +LK+ +++ E H E + RL E +E L ++ +++ E
Sbjct: 1081 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKS-QQLQEK 1139
Query: 755 QRNIVSRKEKISALKKQANHI------VQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 808
Q+ +++ +E++S ++K+ N I ++ + +H E+ L L E + ++
Sbjct: 1140 QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSIT 1199
Query: 809 KKYSSLSG-GKGFPVNPNTLKEGYISVNEINEPCGNST---------NLSPSTQFPADAD 858
K+ L K F + L+ GYI EI E G T +L + +
Sbjct: 1200 KERKVLKELQKSFETERDHLR-GYI--REI-EATGLQTKEELKIAHIHLKEHQETIDELR 1255
Query: 859 AVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMG 918
+E ++ +Q K H + EE H+E + LP K S + TM
Sbjct: 1256 RSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEE----QELLPNVKEVSE-----TQETMN 1306
Query: 919 RSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRT 978
+ L QS + S +LA + E R+ Q+ E E + T
Sbjct: 1307 -----ELELLTEQSTTKDST---TLARI----EMERLRLNEKFQESQE------EIKSLT 1348
Query: 979 ASESNVYL--NSFHYPDHSYKDQAFDTLSL--DSSDSMETSISACSPDNISSASTSNIAR 1034
N+ + K+ +TL+ +S E S++ DN ++ S + +
Sbjct: 1349 KERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ 1408
Query: 1035 IEEMERLLKQAHAE----KTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1090
+ + L + E RL ES + EM++ + ++ +R +E+L+ + ++
Sbjct: 1409 FKPKDSALLRIEIEMLGLSKRLQESHD-EMKSVAKEKDDLQRLQEVLQSESDQLKENIKE 1467
Query: 1091 LIEKEVKIRE 1100
++ K ++ E
Sbjct: 1468 IVAKHLETEE 1477
Score = 55.5 bits (132), Expect = 3e-07
Identities = 136/743 (18%), Positives = 302/743 (40%), Gaps = 104/743 (13%)
Query: 432 QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQK-----------IN 480
+ E + +E +E +E +RLE L Y + S ++++QK
Sbjct: 1164 KNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYI 1223
Query: 481 KELEK--LQLSDEESVFEEALMS-PDTRYRCHRKDSLPDADLASCGSLSQSSASF--FTP 535
+E+E LQ +E + L +T R S A + + L +S P
Sbjct: 1224 REIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIP 1283
Query: 536 RSTRNDELLSDLTRTPPPPSS-------TFPKASSESSYLSILPKTPEGISE--EQRSQE 586
ELL ++ + T + +S+ L+ + ++E ++ +E
Sbjct: 1284 VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEE 1343
Query: 587 LAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEI 646
+ ++ + R +NL+ +K+ ++ +DQ+ E RE + + + K E + MKEK+
Sbjct: 1344 IKSLTKER----DNLKTIKEALEVKHDQLKEHIRE--TLAKIQESQSKQEQSLNMKEKD- 1396
Query: 647 LDHLNRKIAELEKNIVGEKTKEKVKLDAEREKL---ERLQELYSEQKTQLDNCPESMREQ 703
+ + ++E+E+ K K+ L E E L +RLQE + E K+ + R
Sbjct: 1397 -NETTKIVSEMEQ----FKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQR-- 1449
Query: 704 LQQQLKRDADLL-----DVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI 758
LQ+ L+ ++D L ++ +KH E E ++ H +E+E +L ++E + I
Sbjct: 1450 LQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCL--KEQEETINELRVNLSEKETEI 1507
Query: 759 VSRKEKISALKKQANHIVQQAQREQDHF-------VKEKNNLIMMLQREKE----NLCNL 807
+ ++++ A+ + + +Q+ +++ F V+EK N + + ++ L ++
Sbjct: 1508 STIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSI 1567
Query: 808 EKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATA 867
E K L+ N L+E + + + + + Q D E
Sbjct: 1568 ESKMLELT---------NRLQESQEEIQIMIKEKEEMKRVQEALQIERDQ---LKENTKE 1615
Query: 868 VLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHL 927
++A +S +E++ Q + +++T + + F + + ++
Sbjct: 1616 IVAKMKES-------QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENI 1668
Query: 928 PLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTA----SESN 983
L Q +L +L M ++ R LR E + K +
Sbjct: 1669 RLTQ------ILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEE 1722
Query: 984 VYLNSFHYPDHSYK-DQAFDTLSLDSSD------SMETSISACSPDNISSASTSNIARI- 1035
+ + H +H D+ +S +++ +E S A ++ IA +
Sbjct: 1723 LKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMH 1782
Query: 1036 --EEMERL--LKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR---LQEETSQR 1088
E+ E + L+ +EKT L + ++++E L+E+ + + E + L+++ ++
Sbjct: 1783 LKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNET 1842
Query: 1089 QKLIEKEVKIRERQRAQARPLTR 1111
QK + + +++++ + Q+ L++
Sbjct: 1843 QKKVSEMEQLKKQIKDQSLTLSK 1865
Score = 53.9 bits (128), Expect = 9e-07
Identities = 164/829 (19%), Positives = 308/829 (37%), Gaps = 139/829 (16%)
Query: 343 LASTSSCASDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEA--DLESLRQ 400
+ S S S+ D S + NP+ LL E+ + ++D D E LR
Sbjct: 465 VCSESDVFSNTLDTLSEIEWNPATKLLNQEN-----IESELNSLRADYDNLVLDYEQLRT 519
Query: 401 ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEY 460
+ L+E+ +DL ++ +R+ + ++QEM+ + L AE
Sbjct: 520 EKEEMELKLKEK----------NDLDEFEALERKTK-KDQEMQLIHEISNLKNLVKHAEV 568
Query: 461 TKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLA 520
D + VE +++ +++KLQ + E M D Y L
Sbjct: 569 YNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKM--DLSY-----------SLE 615
Query: 521 SCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISE 580
S Q + F + D A ES++L E +
Sbjct: 616 SIEDPKQMKQTLFDAETVALD-------------------AKRESAFLR-----SENLEL 651
Query: 581 EQRSQELAA----MEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE-QKS 635
+++ +ELA ME + + LE K+ D+ ++ +F E+ +L+DG+ K
Sbjct: 652 KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKD 711
Query: 636 ETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKV-------KLDAEREKLERLQELYSE 688
L E +I D E+E+N E +E+V L +E E+L + + SE
Sbjct: 712 LLCNLELEGKITDLQKELNKEVEEN---EALREEVILLSELKSLPSEVERLRKEIQDKSE 768
Query: 689 QKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENL----- 743
+ + + + + ++ + R LL+ K +DL Q ++S D+E +N
Sbjct: 769 ELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKS-TDQEFQNFKTLHM 827
Query: 744 ------------TQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKN 791
+++ +E+ + + ALK + ++ Q+ Q E+ V+E+
Sbjct: 828 DFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQ-EKTREVQERL 886
Query: 792 NLIMMLQREKEN----LCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNL 847
N + L+ + EN L +E++ + ++ L++ V + + + L
Sbjct: 887 NEMEQLKEQLENRDSTLQTVEREKTLIT---------EKLQQTLEEVKTLTQEKDDLKQL 937
Query: 848 SPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGL---------YLSDT 898
S Q D + ++E R+ E KQH+E + +S
Sbjct: 938 QESLQIERDQ---LKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRN 994
Query: 899 LPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRG 958
L ++ T F +G I K L + +L A KD+E R
Sbjct: 995 LHMEENTGETKDEFQQKMVG--IDKKQDLEAKNTQ--------TLTADVKDNEIIEQQRK 1044
Query: 959 Y--------NHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSD 1010
QQM E + E +T + N+ + + + D L
Sbjct: 1045 IFSLIQEKNELQQMLESVIAEKE-QLKTDLKENIEMTIENQEELRLLG---DELKKQQEI 1100
Query: 1011 SMETSISACSPDNISSASTSNIARIEE-MERLLKQAHAEKTRLLESREREMEAKKRALEE 1069
+ A + S + +A +EE ++ +Q ++ +LL +E E +K+ E
Sbjct: 1101 VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1160
Query: 1070 EKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKE 1118
E + E+ K L E + ++L E K+ E + + +T+ V KE
Sbjct: 1161 ENLKNELKNKELTLEHMETERL-ELAQKLNENYE-EVKSITKERKVLKE 1207
Score = 49.3 bits (116), Expect = 2e-05
Identities = 96/469 (20%), Positives = 195/469 (41%), Gaps = 55/469 (11%)
Query: 389 EFDEADLESLRQASGTPQPALRERKSSISSISG-RDDL------MDYHRRQREERLREQE 441
E + +LE++ + L E + S++ RDDL + R Q +E LRE
Sbjct: 1654 ETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETI 1713
Query: 442 MERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMS 501
LE+Q I+ + + + G E +I+ + L+ S++ ++ +
Sbjct: 1714 TRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ 1773
Query: 502 PDTRY-RCHRKD-------------------SLPDADLASCGSLSQSSASFFTPRSTRND 541
+ R H K+ S DL + + Q +
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLI 1833
Query: 542 ELLSDLTRTPPPPSSTFP-KASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVIL-- 598
L D+ T S K + L++ E ++ Q+ E +EE + V+
Sbjct: 1834 TLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHE--NLEEMKSVMKER 1891
Query: 599 NNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAE-- 656
+NL +++ +K DQ+ ES +E + E K+ + KE +D L KI+E
Sbjct: 1892 DNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKT 1951
Query: 657 -----LEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRD 711
++K++ +K+K++++ + + + LQ L ++ + + + EQL++Q +
Sbjct: 1952 IQISDIQKDL--DKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQF--E 2007
Query: 712 ADLLDVESKHFEDLEFQQLEHESRLDE----EKENLTQQLLREVAEYQRN--IVSRKEKI 765
A L ++S ++ + + HES L+E KE + ++E + +R+ I + +E I
Sbjct: 2008 AQNLSMQSVRMDNFQLTKKLHES-LEEIRIVAKERDELRRIKESLKMERDQFIATLREMI 2066
Query: 766 SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 814
+ + + NH Q + E+ + +L L+ + + L K+YS +
Sbjct: 2067 A--RDRQNH---QVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEM 2110
Score = 48.5 bits (114), Expect = 4e-05
Identities = 138/657 (21%), Positives = 246/657 (37%), Gaps = 141/657 (21%)
Query: 571 LPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECAL-- 628
L K E +S E R+Q AME+ ++ L ++L QK++ N++++ R L +L
Sbjct: 355 LKKQLEEVSLETRAQ---AMEKDQLAQLLEEKDLLQKVQ--NEKIENLTRMLVTSSSLTL 409
Query: 629 ---LDGEQKSETT------ELMKEKEILDHLN------RKIAELEKNIVGEKTKEKV-KL 672
L ++K T MK D N K +L N++ E + +
Sbjct: 410 QQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSES 469
Query: 673 DAEREKLERLQELYSEQKTQLDNCPESMREQLQ-------------QQLKRDADLLDVES 719
D L+ L E+ T+L N E++ +L +QL+ + + ++++
Sbjct: 470 DVFSNTLDTLSEIEWNPATKLLN-QENIESELNSLRADYDNLVLDYEQLRTEKEEMELKL 528
Query: 720 KHFEDL-EFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ 778
K DL EF+ LE +++ D+E QL+ E++ +N+V E N ++
Sbjct: 529 KEKNDLDEFEALERKTKKDQE-----MQLIHEISNL-KNLVKHAEVY-------NQDLEN 575
Query: 779 AQREQDHFVKEKNNLIMMLQR--EKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNE 836
+ ++EK + I LQ + + L N++ S S+
Sbjct: 576 ELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLS-------------------YSLES 616
Query: 837 INEPCGNSTNLSPSTQFPADADAVATEPATAVLASQP-QSKEHFRSLEERKKQHKEG--L 893
I +P T F A+ A+ + +A L S+ + KE + L KQ + L
Sbjct: 617 IEDP-----KQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQL 671
Query: 894 YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNS---CGSVLPPSLAAMAKD- 949
Y S +KK + SA IT L G+ C L + + K+
Sbjct: 672 YQSQLEAKKKMQVDLEKELQSAF--NEITKLTSLIDGKVPKDLLCNLELEGKITDLQKEL 729
Query: 950 ------------------------SESRRMLRGYN------HQQMSEGHRQKSEFYNRTA 979
SE R+ + H SE + SE ++ +
Sbjct: 730 NKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKES 789
Query: 980 -----------SESNVYLNSFHYPDHSYKDQAFDTLSLD----------SSDSMETSISA 1018
++ ++ +Y + Q F TL +D ++ M I
Sbjct: 790 RVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVN 849
Query: 1019 CSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILE 1078
S + + S++ ++ Q EKTR ++ R EME K LE + +E
Sbjct: 850 LSKE--AQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVE 907
Query: 1079 KRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDT 1135
+ T + Q+ +E EVK +++ + L L + ++ H +T NIDT
Sbjct: 908 REKTLITEKLQQTLE-EVKTLTQEKDDLKQLQESLQIERDQLKSDIH-DTVNMNIDT 962
Score = 44.7 bits (104), Expect = 6e-04
Identities = 76/384 (19%), Positives = 159/384 (41%), Gaps = 47/384 (12%)
Query: 440 QEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEAL 499
QE L+ Q LE++++ E K D + + T+E+ E+L+L +E ++ +
Sbjct: 1050 QEKNELQ-QMLESVIAE-KEQLKTDLKENIEMTIENQ-------EELRLLGDELKKQQEI 1100
Query: 500 MSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFP 559
++ + + ++ L +C L++ +E L + ++
Sbjct: 1101 VAQEKNHAIKKEGELS----RTCDRLAEV------------EEKLKEKSQQLQEKQQQLL 1144
Query: 560 KASSESSYLSILPKTPEGISEEQRSQELAA--MEETRIVILNNLEELKQKIKDINDQ--- 614
E S + E + E +++EL ME R+ + L E +++K I +
Sbjct: 1145 NVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKV 1204
Query: 615 MDESFRELDMECALLDGE-QKSETTELMKEKEI-LDHLNRK-----IAELEKNIVGEKTK 667
+ E + + E L G ++ E T L ++E+ + H++ K I EL ++ V EKT
Sbjct: 1205 LKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRS-VSEKTA 1263
Query: 668 EKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEF 727
+ + + +LQE + + P Q+ + +LL +S +
Sbjct: 1264 QIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTL 1323
Query: 728 QQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ---------Q 778
++E E EK +Q+ ++ + + + N+ + KE + Q ++ Q
Sbjct: 1324 ARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQ 1383
Query: 779 AQREQDHFVKEKNNLIMMLQREKE 802
+++EQ +KEK+N + E E
Sbjct: 1384 SKQEQSLNMKEKDNETTKIVSEME 1407
>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
sapiens]
Length = 1133
Score = 64.3 bits (155), Expect = 7e-10
Identities = 152/739 (20%), Positives = 297/739 (40%), Gaps = 86/739 (11%)
Query: 429 HRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQL 488
H Q + ++ ++ ++ + IL C + KP S G ED L + L
Sbjct: 23 HSFQGPKNMKHRQQDKDSPSESDVILP-CPKAEKPHS--GNGHQAED-------LSRDDL 72
Query: 489 SDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLT 548
S+ E L + D + + + DLA L ++ F TP+ ++L L
Sbjct: 73 LFLLSILEGELQARDEVIGILKAEKM---DLA----LLEAQYGFVTPK-----KVLEALQ 120
Query: 549 RTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS--QELAAMEETRIVILNNLEELKQ 606
R ST + ++ L K E E R +L E++R + LEE K+
Sbjct: 121 RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180
Query: 607 KIKDINDQMDESFRELDMEC----ALLDGEQKS-ETTELMKEKEI--LDHLNRKIAELEK 659
K K+ ++ DE L+ EC L+D E KS E E KEK + L K+
Sbjct: 181 KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240
Query: 660 NIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVES 719
+V E+ + +L +R+K++ L E T+L ++E+ Q+ + + +L +
Sbjct: 241 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300
Query: 720 KHFEDLE--FQQLEHESRLDEEKENLTQQL------LREVAEYQRNIVSRKEKISALKKQ 771
K +D + +L +E D + L Q+L + E+ E R++ +E++ +K++
Sbjct: 301 KFHQDQDTIMAKLTNE---DSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEK 357
Query: 772 ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS--------GGKGFPVN 823
+ + V+E ++ ++ + E L +E++ L+ K F +
Sbjct: 358 ISK-GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLE 416
Query: 824 PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE 883
L + +++ ++ + S S + + + + T+ + L S + ++E
Sbjct: 417 VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIE 476
Query: 884 ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 943
R + K L + L + KT + + TM + K L ++S V +
Sbjct: 477 SRLE--KTEFTLKEDLTKLKTLTVMFVD-ERKTMSEKL-KKTEDKLQAASSQLQVEQNKV 532
Query: 944 AAMAKD--SESRRMLRGYN--HQQMSEGHRQKSEFYNRTASES----------NVYLNSF 989
+ + E++R L+ ++M +++ + N+ +E N+ N
Sbjct: 533 TTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRL 592
Query: 990 HYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEK 1049
+ KD + L+ DS S +A +N S +E ++ LK A +
Sbjct: 593 QSLEAIEKDFLKNKLNQDSG----KSTTALHQENNKIKELSQ--EVERLKLKLKDMKAIE 646
Query: 1050 TRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQ--RQKLIEKE--------VKIR 1099
L+++ E E E +R E+ + + L K L+ + + KL EK K
Sbjct: 647 DDLMKT-EDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRL 705
Query: 1100 ERQRAQARPLTRYLPVRKE 1118
+ + A++ L+R + KE
Sbjct: 706 QEEEAKSGHLSREVDALKE 724
>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
sapiens]
Length = 1135
Score = 64.3 bits (155), Expect = 7e-10
Identities = 152/739 (20%), Positives = 297/739 (40%), Gaps = 86/739 (11%)
Query: 429 HRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQL 488
H Q + ++ ++ ++ + IL C + KP S G ED L + L
Sbjct: 23 HSFQGPKNMKHRQQDKDSPSESDVILP-CPKAEKPHS--GNGHQAED-------LSRDDL 72
Query: 489 SDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLT 548
S+ E L + D + + + DLA L ++ F TP+ ++L L
Sbjct: 73 LFLLSILEGELQARDEVIGILKAEKM---DLA----LLEAQYGFVTPK-----KVLEALQ 120
Query: 549 RTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS--QELAAMEETRIVILNNLEELKQ 606
R ST + ++ L K E E R +L E++R + LEE K+
Sbjct: 121 RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180
Query: 607 KIKDINDQMDESFRELDMEC----ALLDGEQKS-ETTELMKEKEI--LDHLNRKIAELEK 659
K K+ ++ DE L+ EC L+D E KS E E KEK + L K+
Sbjct: 181 KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240
Query: 660 NIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVES 719
+V E+ + +L +R+K++ L E T+L ++E+ Q+ + + +L +
Sbjct: 241 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300
Query: 720 KHFEDLE--FQQLEHESRLDEEKENLTQQL------LREVAEYQRNIVSRKEKISALKKQ 771
K +D + +L +E D + L Q+L + E+ E R++ +E++ +K++
Sbjct: 301 KFHQDQDTIMAKLTNE---DSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEK 357
Query: 772 ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS--------GGKGFPVN 823
+ + V+E ++ ++ + E L +E++ L+ K F +
Sbjct: 358 ISK-GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLE 416
Query: 824 PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE 883
L + +++ ++ + S S + + + + T+ + L S + ++E
Sbjct: 417 VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIE 476
Query: 884 ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 943
R + K L + L + KT + + TM + K L ++S V +
Sbjct: 477 SRLE--KTEFTLKEDLTKLKTLTVMFVD-ERKTMSEKL-KKTEDKLQAASSQLQVEQNKV 532
Query: 944 AAMAKD--SESRRMLRGYN--HQQMSEGHRQKSEFYNRTASES----------NVYLNSF 989
+ + E++R L+ ++M +++ + N+ +E N+ N
Sbjct: 533 TTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRL 592
Query: 990 HYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEK 1049
+ KD + L+ DS S +A +N S +E ++ LK A +
Sbjct: 593 QSLEAIEKDFLKNKLNQDSG----KSTTALHQENNKIKELSQ--EVERLKLKLKDMKAIE 646
Query: 1050 TRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQ--RQKLIEKE--------VKIR 1099
L+++ E E E +R E+ + + L K L+ + + KL EK K
Sbjct: 647 DDLMKT-EDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRL 705
Query: 1100 ERQRAQARPLTRYLPVRKE 1118
+ + A++ L+R + KE
Sbjct: 706 QEEEAKSGHLSREVDALKE 724
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 63.5 bits (153), Expect = 1e-09
Identities = 124/604 (20%), Positives = 237/604 (39%), Gaps = 101/604 (16%)
Query: 580 EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLD---GEQKSE 636
EE++++ LA + + V++++LEE +K + +++++ R+LD E L E +++
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1077
Query: 637 TTEL-----MKEKE--------------------ILDHLNRKIAELEKNIVGEKTKEKVK 671
EL KE+E ++ L +IAEL+++ EK
Sbjct: 1078 IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137
Query: 672 LDAEREKLERLQELYSEQKTQLDN--CPESMREQLQQQLKRDADLLDVESKHFE-DLEFQ 728
+R+ E L+ L +E + LD + +R + +Q++ L+ E+K+ E ++
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197
Query: 729 QLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQAN---HIVQQAQREQDH 785
+ H + L+E E L Q ++ N+ K+ + K+ ++QQ + E +H
Sbjct: 1198 RQRHATALEELSEQLEQ-----AKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEH 1252
Query: 786 --------------FVKEKNNLIMMLQREKENLCNLEKKYSSL-----SGGKGFPVNPNT 826
V E + L + L + L N S+L G F + +
Sbjct: 1253 KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAAS 1312
Query: 827 LKEGYISVNE-INEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEER 885
L+ E + E NLS + E L Q + +E E R
Sbjct: 1313 LESQLQDTQELLQEETRQKLNLSSRIR--------QLEEEKNSLQEQQEEEE-----EAR 1359
Query: 886 KKQHKEGLYLSDTL--PRKKTTSSISPHFSSATMGRSITPKAHL---PLGQSNSCGSVLP 940
K K+ L L L +KK + S + + A L + L
Sbjct: 1360 KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLE 1419
Query: 941 PSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQA 1000
+ + ++ + + + Q S +++ +F A E ++ S Y + +D+A
Sbjct: 1420 KTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI---SARYAEE--RDRA 1474
Query: 1001 FDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESRE--- 1057
+++ E A S ++ A + EE ER KQ A+ L+ S++
Sbjct: 1475 -------EAEAREKETKALS---LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVG 1524
Query: 1058 ---REMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLP 1114
E+E KRALE++ E + +L+E + Q + ++++ +A R L
Sbjct: 1525 KNVHELEKSKRALEQQV---EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581
Query: 1115 VRKE 1118
R E
Sbjct: 1582 TRDE 1585
Score = 63.2 bits (152), Expect = 2e-09
Identities = 109/538 (20%), Positives = 214/538 (39%), Gaps = 72/538 (13%)
Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640
+ ++ A EE R + +EL++ + D+ +++E + +L E+K +
Sbjct: 897 QAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEE----EERNQILQNEKKKMQAHI 952
Query: 641 MKEKEILDHLN--RKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPE 698
+E LD R+ +LEK K K K++ E LE + ++K +++
Sbjct: 953 QDLEEQLDEEEGARQKLQLEKVTAEAKIK---KMEEEILLLEDQNSKFIKEKKLMEDRIA 1009
Query: 699 SMREQLQQQLKRDADLLDVESKH---FEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQ 755
QL ++ ++ +L + +K DLE ++L+ E + +E E ++L E + Q
Sbjct: 1010 ECSSQLAEEEEKAKNLAKIRNKQEVMISDLE-ERLKKEEKTRQELEKAKRKLDGETTDLQ 1068
Query: 756 RNIVSRKEKISALKKQA---NHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYS 812
I + +I LK Q +Q A D KNN + +++ + + L++ +
Sbjct: 1069 DQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFE 1128
Query: 813 SLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ 872
S + N ++ ++E E T+ D A + Q
Sbjct: 1129 SEKASR------NKAEKQKRDLSEELEAL--------KTELEDTLDTTAAQQELRTKREQ 1174
Query: 873 PQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTT-SSISPHFSSATMGRSITPKAHLPLGQ 931
+ E ++LEE K H+ + D R T +S A ++ K L
Sbjct: 1175 -EVAELKKALEEETKNHEA--QIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLET 1231
Query: 932 SNSCGSVLPPSLAAMAKDSESRRMLRGYN----HQQMSEGHRQKSEFYNRTASESNVYLN 987
N + L + +SE +R H ++SEG R + E + + N
Sbjct: 1232 DNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN---- 1287
Query: 988 SFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSA--STSNIARIEEMERLLKQA 1045
D++ T + I A + S +++++ + LL++
Sbjct: 1288 --------------------ELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEE 1327
Query: 1046 HAEKTRLLESREREMEAKKRAL----EEEKRRREILEKR---LQEETSQRQKLIEKEV 1096
+K L SR R++E +K +L EEE+ R+ LEK+ LQ + + +K ++ ++
Sbjct: 1328 TRQKLNL-SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDL 1384
Score = 59.3 bits (142), Expect = 2e-08
Identities = 110/581 (18%), Positives = 223/581 (38%), Gaps = 112/581 (19%)
Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640
+ + +EL ++E + + LEE+++K + + ++ + +L E L ++
Sbjct: 855 QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLA 914
Query: 641 MKE---KEILDHLNRKIAELEKN---IVGEKTK------------------------EKV 670
K+ +EIL L ++ E E+ + EK K EKV
Sbjct: 915 AKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKV 974
Query: 671 KLDAEREKLERLQELYSEQKT-----------QLDNCPESMREQLQQQLKRDADLLDVES 719
+A+ +K+E L +Q + ++ C + E+ +++ K A + + +
Sbjct: 975 TAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE-EEKAKNLAKIRNKQE 1033
Query: 720 KHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQ---ANHIV 776
DLE ++L+ E + +E E ++L E + Q I + +I LK Q +
Sbjct: 1034 VMISDLE-ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEEL 1092
Query: 777 QQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNE 836
Q A D KNN + +++ + + L++ + S + N ++ ++E
Sbjct: 1093 QGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR------NKAEKQKRDLSE 1146
Query: 837 INEPCGNSTNLSPSTQFPADADAVAT----EPATAVLASQPQSKEHFRSLEERKKQHKEG 892
E T L + A + T E A A + ++K H +++ +++H
Sbjct: 1147 ELEAL--KTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATA 1204
Query: 893 LYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSES 952
L +S A ++ K L N + L + +SE
Sbjct: 1205 L------------EELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEH 1252
Query: 953 RRMLRGYN----HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDS 1008
+R H ++SEG R + E + + N
Sbjct: 1253 KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN------------------------E 1288
Query: 1009 SDSMETSISACSPDNISSA--STSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRA 1066
D++ T + I A + S +++++ + LL++ +K L SR R++E +K +
Sbjct: 1289 LDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLN-LSSRIRQLEEEKNS 1347
Query: 1067 LEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQAR 1107
L+E+ QEE + +K +EK+V + Q A +
Sbjct: 1348 LQEQ-----------QEEEEEARKNLEKQVLALQSQLADTK 1377
Score = 53.1 bits (126), Expect = 2e-06
Identities = 145/752 (19%), Positives = 275/752 (36%), Gaps = 141/752 (18%)
Query: 367 SLLAGESDRVFATRRNFSCGSVEF--DEADLESLRQASGTPQPALRERKSSISSISGRDD 424
S L E D V ++F D A LES Q + Q L+E ++S R
Sbjct: 1283 SKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT---QELLQEETRQKLNLSSRIR 1339
Query: 425 LMDYHRRQREERLREQEMER--LERQRLETILSLCAEYTKPDSRLSTGTTVEDVQK-INK 481
++ + +E+ E+E R LE+Q L L K D L T ++E+ +K + K
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399
Query: 482 ELEKL-QLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
+ E L Q +E+++ + L R + D D D + AS + +
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH------QRQVASNLEKKQKKF 1453
Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
D+LL++ E S + + + E R +E A+ R L
Sbjct: 1454 DQLLAE-----------------EKSISARYAEERDRAEAEAREKETKALSLARA--LEE 1494
Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
E K++ + N Q+ DME +LM K D + + + ELEK+
Sbjct: 1495 ALEAKEEFERQNKQL-----RADME-------------DLMSSK---DDVGKNVHELEKS 1533
Query: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
L++ E +TQL+ + ++ +L+ + ++ ++++
Sbjct: 1534 ------------------KRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQ 1575
Query: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI----------VSRKEKISALKK 770
DL+ + DE+ E + L+++V E + + V+ K+K+ K
Sbjct: 1576 FERDLQTR--------DEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLK 1627
Query: 771 QANHIVQQAQREQDHFVKEKNNLIMML---QREKENLCNLEKKYSSLSGGKGFPVNPNTL 827
++ A + +D +K+ L + QRE E + + S + L
Sbjct: 1628 DLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQS-----KESEKKL 1682
Query: 828 KEGYISVNEINEPCGNSTNLSPSTQFPAD--ADAVATEPA--TAVLASQPQSKEHFRSLE 883
K + ++ E +S + D AD + + +A+L + + + LE
Sbjct: 1683 KSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLE 1742
Query: 884 ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 943
E ++ + + L + RK T Q ++ + L
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTL-------------------------QVDTLNAELAAER 1777
Query: 944 AAMAKDSESRRMLRGYNHQ---QMSEGHRQKSEFYNRTASESNVYLNSFHYP-DHSYKDQ 999
+A K +R+ L N + ++ E + T S + + K++
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKER 1837
Query: 1000 AFDTLSLDSSDS------METSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLL 1053
A + ++ M+ D AR+++++R L++A E TR
Sbjct: 1838 AAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRAN 1897
Query: 1054 ESR---EREMEAKKRALEEEKRRREILEKRLQ 1082
SR +RE++ A E R L+ RL+
Sbjct: 1898 ASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929
Score = 52.8 bits (125), Expect = 2e-06
Identities = 88/446 (19%), Positives = 183/446 (41%), Gaps = 62/446 (13%)
Query: 411 ERKSSISSISGRDDLM--DYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS 468
E+ +++ I + ++M D R ++E QE+E+ +R+ L E T +++
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK-------LDGETTDLQDQIA 1072
Query: 469 TGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528
++Q EL KLQL+ +E + AL D H+ ++L +++
Sbjct: 1073 ------ELQAQIDEL-KLQLAKKEEELQGALARGDDE-TLHKNNALKVVRELQA-QIAEL 1123
Query: 529 SASFFTPRSTRN----------DEL------LSDLTRTPPPPSSTFPKASSESSYLSIL- 571
F + +++RN +EL L D T K E + L
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183
Query: 572 ---PKTPEGISEEQRSQELAAMEETRIVILN------NLEELKQKIKDINDQMDESFREL 622
K E ++ R + A+EE + NLE+ KQ ++ N ++ + L
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVL 1243
Query: 623 DMECALLDGEQK---SETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKL 679
A + ++K ++ EL + D L ++AE + E L+ +K
Sbjct: 1244 QQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKG 1303
Query: 680 ERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEE 739
+ + + ++QL + E ++E+ +Q+L + + +E + E Q+ E E+R + E
Sbjct: 1304 IKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363
Query: 740 KENLTQQ---------------LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQD 784
K+ L Q + + E ++ ++ E +S ++ + ++ ++
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN 1423
Query: 785 HFVKEKNNLIMMLQREKENLCNLEKK 810
+E ++L + L +++ NLEKK
Sbjct: 1424 RLQQELDDLTVDLDHQRQVASNLEKK 1449
Score = 50.1 bits (118), Expect = 1e-05
Identities = 146/780 (18%), Positives = 316/780 (40%), Gaps = 78/780 (10%)
Query: 391 DEADLESLRQASGTP-QPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER-Q 448
D D + +Q T + + E K ++ + + RQR E+ E+LE+ +
Sbjct: 1157 DTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216
Query: 449 RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYR 507
R + L + + D++ V+ +Q++ E E + + V E A +S R R
Sbjct: 1217 RFKANLEKNKQGLETDNK-ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR 1275
Query: 508 CH--RKDSLPDADLASCGSLSQSS----------ASFFTPRSTRNDELLSDLTRTPPPPS 555
K S +L + +L + + A+ + ELL + TR S
Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335
Query: 556 STFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETR---------IVILNNLEELKQ 606
S + E + L + E + Q LA + + + +LEE K+
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 607 KI-KD---INDQMDE---SFRELDMECALLDGEQKSETTELMKEKEILDHLNRK------ 653
K+ KD ++ +++E ++ +L+ L E T +L ++++ +L +K
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 654 -IAELEKNIVGEKTKEKVKLDAE-REK------LERLQELYSEQKTQLDNCPESMREQLQ 705
+AE EK+I +E+ + +AE REK L R E E K + + + +R ++
Sbjct: 1456 LLAE-EKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514
Query: 706 QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765
+ D+ K+ +LE + E +++E + L ++L E+ + + + +
Sbjct: 1515 DLMSSKDDV----GKNVHELEKSKRALEQQVEEMRTQL-EELEDELQATEDAKLRLEVNM 1569
Query: 766 SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS--GGKGFPVN 823
A+K Q +Q + + EK L++ RE E E+K +L+ K ++
Sbjct: 1570 QAMKAQFERDLQTRDEQNE----EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID 1625
Query: 824 PNTLKEGYISVNEI-NEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSL 882
L+ + N+ +E L + A + A +S++ +SL
Sbjct: 1626 LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL 1685
Query: 883 EERKKQHKEGLYLSDTLPR--KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLP 940
E Q +E L S+ R ++ ++ +++ G+S L + L
Sbjct: 1686 EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL------LDEKRR----LE 1735
Query: 941 PSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQA 1000
+A + ++ E + N + +++ R+ + + +E ++ D++ +
Sbjct: 1736 ARIAQLEEELEEEQS----NMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLE 1791
Query: 1001 FDTLSLDSS-DSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESRERE 1059
L + +E ++ + IS A + I ++EE + A +L+ E++
Sbjct: 1792 RQNKELKAKLQELEGAVKSKFKATIS-ALEAKIGQLEEQLEQEAKERAAANKLVRRTEKK 1850
Query: 1060 MEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKED 1119
++ +E+E+R + ++++ E+ + R K ++++++ E + +A R L +D
Sbjct: 1851 LKEIFMQVEDERRHADQYKEQM-EKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909
Score = 30.8 bits (68), Expect = 8.5
Identities = 22/83 (26%), Positives = 43/83 (51%), Gaps = 11/83 (13%)
Query: 1056 REREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQR------AQARPL 1109
+E E++AK L + K ++ +E L+E + Q+L+E++ + E+ + A+A +
Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 1110 TRYLPVRKEDF-----DLRSHVE 1127
L +K++ DL S VE
Sbjct: 910 RARLAAKKQELEEILHDLESRVE 932
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 62.0 bits (149), Expect = 3e-09
Identities = 128/605 (21%), Positives = 259/605 (42%), Gaps = 94/605 (15%)
Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQM-DESFRELDMECALLDGEQKSETTE 639
+Q + A + ++ +LN LEE K+K++D+ ++ +ES + D+E A + +KS E
Sbjct: 411 DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATV--SEKSRIME 468
Query: 640 LMKE-----KEILD------------------HLNRKIAELEKNIVGEKTKEKVKLDAER 676
L K+ +E+ + L ++I+ L++ + +T + ++ + +
Sbjct: 469 LEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK 528
Query: 677 EKLERLQELYSEQ-------KTQLDNCPESMREQLQQQLKRDADLLDV-ESKHFEDLEFQ 728
E +E + ++ +L ES++ +L+ K ++D++ + +SK LE
Sbjct: 529 EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSK----LETA 584
Query: 729 QLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDH--- 785
H+ ++E K + ++ L E AE+ K +I ++ H ++ Q +QD
Sbjct: 585 IASHQQAMEELKVSFSKGLGTETAEF----AELKTQIEKMRLDYQHEIENLQNQQDSERA 640
Query: 786 -FVKEKNNL---IMMLQREKENLCNLEKKYSSLSGGKG-----FPVNPNTLKEGYISVNE 836
KE L +M + +EKEN +LE S L + N L+E I V E
Sbjct: 641 AHAKEMEALRAKLMKVIKEKEN--SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE 698
Query: 837 ---INEPCGNSTNL--SPSTQFPADADAVATEPATAVLASQPQS--KEHFRSLEERKKQH 889
+ C T + + ++Q A + + A +S+ +S K+ + LE +KQ
Sbjct: 699 LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQI 758
Query: 890 KEGLYLSDTLPRKKTTSSISPHFSSATMGRSI-TPKAHLPLGQSNSCGSVLPPSLAAM-- 946
K K SS + + GR + L + + L L +
Sbjct: 759 KH------LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE 812
Query: 947 --AKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSY--KDQAFD 1002
A+ SE ++ + +++ H QK E +N +S+ + + + KD+ +
Sbjct: 813 KFAEASEEAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREE 871
Query: 1003 TLSLDSSDSMETSIS---ACSPDNISSASTSN------IARIEEMERLLKQAHAEKTRLL 1053
L + + + +E I+ S DN S + N +EE++ L +A+ + L
Sbjct: 872 QL-IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQ 930
Query: 1054 ESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIE------KEVKIRERQRAQAR 1107
+S E +++ +E ++ E +K L+ + S +K +E +E+K R +RA +
Sbjct: 931 KSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR-YERATSE 989
Query: 1108 PLTRY 1112
T++
Sbjct: 990 TKTKH 994
Score = 55.8 bits (133), Expect = 2e-07
Identities = 124/583 (21%), Positives = 222/583 (38%), Gaps = 87/583 (14%)
Query: 261 RATENQLTPL-SLPPRNSLGNSKRTKL------GEKDLPHSVIDNDNYLNFSSLSSGALP 313
+ATE +L L +L +S G S+ KL EK + H I+ N S + ++
Sbjct: 721 KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK----NAESSKASSI- 775
Query: 314 YKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGES 373
T +G + L S K L + F +AS + S+
Sbjct: 776 --TRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE-TV 832
Query: 374 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERK-----------------SSI 416
+++ F+ S +DLE LR+ + RE+ + I
Sbjct: 833 NKLHQKEEQFNMLS-----SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEI 887
Query: 417 SSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDV 476
+SG D+ + E RL+E+++E L+ + TK + E+
Sbjct: 888 MKMSG-DNSSQLTKMNDELRLKERDVEELQ-----------LKLTKAN---------ENA 926
Query: 477 QKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASF 532
+ K +E + + E+S E A + + RK S + + + C L
Sbjct: 927 SFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERA 986
Query: 533 FTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEE 592
+ T+++E+L +L +T A E+S +L + E + +++ E+
Sbjct: 987 TSETKTKHEEILQNLQKTLLDTEDKLKGAREENS--GLLQELEELRKQADKAKAAQTAED 1044
Query: 593 TRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNR 652
++ +E + + + D + + L E L EL K KE+L N+
Sbjct: 1045 AMQIMEQMTKEKTETLASLEDTKQTNAK-LQNELDTLKENNLKNVEELNKSKELLTVENQ 1103
Query: 653 KIAELEKNI------VGEKTKEKVKLDAEREKL-ERL----QELYSEQKTQLDNCPESMR 701
K+ E K I +K+++ L E KL E L E+ S QK L+ +
Sbjct: 1104 KMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQK--LEEERSVLN 1161
Query: 702 EQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSR 761
QL + KR++ + + L+ + + S L EK+ ++L EV V R
Sbjct: 1162 NQLLEMKKRESKFIKDADEEKASLQ-KSISITSALLTEKDAELEKLRNEVT------VLR 1214
Query: 762 KEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENL 804
E SA K + +VQ + ++ + NL + L+ K L
Sbjct: 1215 GENASA--KSLHSVVQTLESDKVKLELKVKNLELQLKENKRQL 1255
Score = 53.9 bits (128), Expect = 9e-07
Identities = 90/455 (19%), Positives = 188/455 (41%), Gaps = 80/455 (17%)
Query: 409 LRERKSSISSISGR-DDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRL 467
++E+++S+ +I + D D H + E+ L + + ++ + LE + + C E TK
Sbjct: 657 IKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK----- 711
Query: 468 STGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASC----- 522
I+ +L+ ++E+ + +AL + + K + A
Sbjct: 712 ----------VIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL 761
Query: 523 ---GSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYL--SILPKTPEG 577
+ S AS T + L++L S E L + E
Sbjct: 762 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEA 821
Query: 578 ISEEQRSQE----LAAMEETRIVILNNLEELKQKIKDINDQMDESFRELD---------- 623
+S ++ QE L EE ++ ++LE+L++ + D M+ FRE D
Sbjct: 822 VSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD----MEAKFREKDEREEQLIKAK 877
Query: 624 -------MECALLDGEQKSETTEL-----MKEKEILDHLNRKIAELEKNI-VGEKTKEKV 670
E + G+ S+ T++ +KE+++ + L K+ + +N +K+ E +
Sbjct: 878 EKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV-EELQLKLTKANENASFLQKSIEDM 936
Query: 671 KLDAEREKLERLQELYSEQKTQLDNCPESMREQLQ------QQLKR--DADLLDVESKHF 722
+ AE+ + E ++ + E+K +L+ + ++++ Q+LK + + ++KH
Sbjct: 937 TVKAEQSQQEAAKK-HEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHE 995
Query: 723 EDLEFQQ---LEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQA 779
E L+ Q L+ E +L +E LL+E+ E ++ A K +A + A
Sbjct: 996 EILQNLQKTLLDTEDKLKGAREE-NSGLLQELEELRK---------QADKAKAAQTAEDA 1045
Query: 780 QREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 814
+ + KEK + L+ K+ L+ + +L
Sbjct: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1080
Score = 53.5 bits (127), Expect = 1e-06
Identities = 116/587 (19%), Positives = 225/587 (38%), Gaps = 85/587 (14%)
Query: 577 GISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDE--SFRELDMECALLDGEQK 634
G EE +E+ A+ + E LK K++ N + + + + +E A+ +Q
Sbjct: 532 GAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQA 591
Query: 635 SETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLD 694
E ++ K L + AEL+ I EK++LD + E +E LQ ++
Sbjct: 592 MEELKVSFSKG-LGTETAEFAELKTQI------EKMRLDYQHE-IENLQNQQDSERAAHA 643
Query: 695 NCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL-EHESRLDEEKE------------ 741
E++R +L + +K + L+ + E Q L E E L++ +E
Sbjct: 644 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 703
Query: 742 -----------NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ---AQREQDHFV 787
N T QL + E ++ + ++ S K + + QQ A+++ H
Sbjct: 704 AKCNEQTKVIDNFTSQL-KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE 762
Query: 788 KEKN-------NLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
EKN ++ LQ + L NL++ S +S V KE I + E
Sbjct: 763 IEKNAESSKASSITRELQGRELKLTNLQENLSEVS-----QVKETLEKELQILKEKFAEA 817
Query: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEH-------FRSLEERKKQ---HK 890
+ ++ S Q + E + + + +E+ FR +ER++Q K
Sbjct: 818 SEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAK 877
Query: 891 EGLY--LSDTLPRKKTTSS-ISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMA 947
E L +++ + SS ++ + + L L ++N S L S+ M
Sbjct: 878 EKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMT 937
Query: 948 KDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLD 1007
+E + Q+ ++ H ++ + R S+ + + H K + ++ + +
Sbjct: 938 VKAEQ-------SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR-YERATSE 989
Query: 1008 SSDSMETSISAC------SPDNISSASTSNIARIEEMERLLKQAHAEKT--------RLL 1053
+ E + + D + A N ++E+E L KQA K +++
Sbjct: 990 TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIM 1049
Query: 1054 ESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRE 1100
E +E +LE+ K+ L+ L K +E+ K +E
Sbjct: 1050 EQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKE 1096
Score = 35.4 bits (80), Expect = 0.34
Identities = 61/280 (21%), Positives = 118/280 (42%), Gaps = 29/280 (10%)
Query: 534 TPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTP---EGISEEQR--SQELA 588
+P ++ + S + PS T + S Y + T E + E+Q+ Q LA
Sbjct: 310 SPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLA 369
Query: 589 AMEETRIVIL---NNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
+ R + +++ E++Q++ D D+ EL+ + L ++ E ++
Sbjct: 370 ERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLN 429
Query: 646 ILDHLNRKIAELEKNIVGEK-TKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQL 704
L+ RK+ +L+ + E TK +++ EK R+ EL + ++ E L
Sbjct: 430 QLEEEKRKVEDLQFRVEEESITKGDLEVATVSEK-SRIMELEKDLALRVQEVAE-----L 483
Query: 705 QQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEK 764
+++L+ + DV D+ L+ S L +EK +T+ ++QR I S KE
Sbjct: 484 RRRLESNKPAGDV------DMSLSLLQEISSL-QEKLEVTR------TDHQREITSLKEH 530
Query: 765 ISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQR-EKEN 803
A ++ ++ + KE +L L+ KEN
Sbjct: 531 FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKEN 570
Score = 34.3 bits (77), Expect = 0.77
Identities = 27/104 (25%), Positives = 52/104 (50%), Gaps = 24/104 (23%)
Query: 1028 STSNIARIEEMERLLKQAHAEKTRLLESR-----------EREMEAKKRALEEEKRRREI 1076
+TS++ IE+ L + H + LE++ +RE LEEEKR+ E
Sbjct: 381 ATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVED 440
Query: 1077 LEKRLQEET-----------SQRQKL--IEKEVKIRERQRAQAR 1107
L+ R++EE+ S++ ++ +EK++ +R ++ A+ R
Sbjct: 441 LQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELR 484
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 62.0 bits (149), Expect = 3e-09
Identities = 151/727 (20%), Positives = 292/727 (40%), Gaps = 92/727 (12%)
Query: 137 ERALRLSE-KPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISR 195
E+A+R+ + + S+Y R HD + +E K +L + + L D +R
Sbjct: 317 EKAVRVDKLESEVSRYKER--LHDIEFYKARVEELKEDNQVL-LETKTMLEDQLEGTRAR 373
Query: 196 SGAASMPSSPKQARKMSIQDSLALQPKLTRHK--ELASENINLR-TRKYSSSSLSHMGAY 252
S K + D + ++ + R K EL EN+ L +K S H+G
Sbjct: 374 SDKLHELEKENLQLKAKLHD-MEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGW- 431
Query: 253 SRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGAL 312
L ++ R +E LS P+ SLG+ + L + + L +
Sbjct: 432 --ELEQISRTSE-----LSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
Query: 313 PYKTSASE------GNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV------ 360
+ +AS+ N +S + + + V K L + + + D + + +
Sbjct: 485 SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
Query: 361 ---GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS 417
+ +L E++ + T + S EA ++ + + + +++E S +S
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
Query: 418 SISG-----RDDLMDYHRRQREERLREQEMERLER-----QRLETILSLCAEYTKPDSRL 467
I + +L Y + E E+ LE+ Q+ T L + E + +
Sbjct: 605 KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664
Query: 468 STGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYRCHRKDSLPDADLASCGSLS 526
++ ++++ N++L+K S + F+ E+L +++ + + + C S+
Sbjct: 665 NS-----ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK 719
Query: 527 QSSASFFTPRSTRNDELLSD---LTRTPPPPSSTFPKASS-ESSYLSI------LPKTPE 576
+ N EL S+ L + ++F K E SY + L KT E
Sbjct: 720 MAQLQL------ENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE 773
Query: 577 GISE--EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQK 634
++ +Q EL +E + NLEELK K + +Q+++ + L+ E + L+ ++K
Sbjct: 774 NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL-EQLEKENKSLEQETSQLEKDKK 832
Query: 635 S---ETTELMKEKEI----LDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYS 687
E L ++ EI L+ N KI LEK KT K ++ +E RL+EL
Sbjct: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE---NKTLSK-EIGIYKESCVRLKELEK 888
Query: 688 EQKTQLDNCP------ESMREQL------QQQLKRDADLLDVESKHFEDLEFQQLEHESR 735
E K + ++RE L QQ+ D + L E + L ++L H+ +
Sbjct: 889 ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI-GLNKERLLHDEQ 947
Query: 736 LDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIM 795
+++ L + L + +++ ++EKI+AL+ + Q+ + K N
Sbjct: 948 STDDRYKLLESKLESTLK--KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1005
Query: 796 MLQREKE 802
+ QR+ E
Sbjct: 1006 LKQRQDE 1012
Score = 53.5 bits (127), Expect = 1e-06
Identities = 92/453 (20%), Positives = 176/453 (38%), Gaps = 54/453 (11%)
Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREER--LREQEMERLERQR 449
+A + LRQ L + K + + ++ R Q+E L + R+ R
Sbjct: 257 KAKIRRLRQELEEKTEQLLDCKQELEQME-----IELKRLQQENMNLLSDARSARMYRDE 311
Query: 450 LETILSLCAEYTKPDSRLST-GTTVEDVQKINKELEKLQLSDEESVFEEALMSPD----T 504
L+ + K +S +S + D++ +E+L+ D + + E M D T
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK-EDNQVLLETKTMLEDQLEGT 370
Query: 505 RYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKAS-- 562
R R + L +L L R + + ++T S
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430
Query: 563 ------SESSYLSILPKTPEGIS-EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQM 615
S +S LS P+ G E S L +E + +EEL+ + +
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA 490
Query: 616 DESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAE 675
+ + ++ E L + + E+++EK+ L + L K+++ EK + + ++
Sbjct: 491 SKILK-MEKENQRLSKKVEILENEIVQEKQSLQNCQN----LSKDLMKEKAQLEKTIETL 545
Query: 676 REKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVE-------------SKHF 722
RE ER ++ ++ L+ S+R+ + Q+ +A + D+E S
Sbjct: 546 RENSERQIKILEQENEHLNQTVSSLRQ--RSQISAEARVKDIEKENKILHESIKETSSKL 603
Query: 723 EDLEFQ------QLEH---ESRLDEEKENLTQQLLREVAEYQRNIVSRK---EKISALKK 770
+EF+ +LEH + EE EN L +E Q+ I + K EKI AL++
Sbjct: 604 SKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663
Query: 771 QANHIVQQAQREQDHFVKEKNNLIMMLQREKEN 803
+ + + ++ ++ + KN + EKEN
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKEN 696
Score = 47.8 bits (112), Expect = 7e-05
Identities = 116/567 (20%), Positives = 226/567 (39%), Gaps = 56/567 (9%)
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQM-DESFRELDMECALLDGEQKSETTELMKEK 644
EL A+ E + +++L+ ++ +++ D F + +E D + ET +++++
Sbjct: 311 ELDALREKAV----RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 366
Query: 645 -EILDHLNRKIAELEKNIVGEKTK---EKVKLDAEREKLERLQELYSEQKTQLDNCPESM 700
E + K+ ELEK + K K +++ D +R+K+E L E E T +SM
Sbjct: 367 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME---ENMTLEMAQKQSM 423
Query: 701 REQLQ-----QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQ 755
E L +Q+ R ++L + K E +L L E EN Q L + V E +
Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGH-EVNELTSSRLLKLEMEN--QSLTKTVEELR 480
Query: 756 RNIVS---RKEKISALKKQANHIVQQAQREQDHFVKEKN------NLIMMLQREKENLCN 806
+ S KI ++K+ + ++ + ++ V+EK NL L +EK
Sbjct: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK---AQ 537
Query: 807 LEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPAT 866
LEK +L N+ ++ I E ++L +Q A+A E
Sbjct: 538 LEKTIETL--------RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589
Query: 867 AVL-ASQPQSKEHFRSLEERKKQHKEGL-YLSDTLPRKKTTSSISPHFSSAT--MGRSIT 922
+L S ++ +E K+Q K+ L + + R + + H + + IT
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKIT 649
Query: 923 PKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASES 982
+C + + E+R++ + + + + E N E
Sbjct: 650 -------NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE 702
Query: 983 NVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLL 1042
N+ L + L L++ + + AS R+E + L
Sbjct: 703 NLELRR-NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL 761
Query: 1043 KQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQE--ETSQRQKLIEKEVKIRE 1100
+ + LE+ ++++ + L++ + + L+K L+E +S+R + +EKE K E
Sbjct: 762 DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLE 821
Query: 1101 RQRAQARPLTRYLPVRKEDFDLRSHVE 1127
++ +Q + L KE+ LR E
Sbjct: 822 QETSQLEKDKKQL--EKENKRLRQQAE 846
Score = 47.0 bits (110), Expect = 1e-04
Identities = 86/418 (20%), Positives = 180/418 (43%), Gaps = 80/418 (19%)
Query: 432 QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINK---------- 481
+R+ ++ EQE E L +T+ SL + S++S V+D++K NK
Sbjct: 550 ERQIKILEQENEHLN----QTVSSL-----RQRSQISAEARVKDIEKENKILHESIKETS 600
Query: 482 ------ELEKLQLSDEESVFEE----ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSAS 531
E EK Q+ E ++E A + + +++ L + + + +
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
Query: 532 FFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQ-------RS 584
++ S+L R T + + L L K + EE S
Sbjct: 661 L--------EQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712
Query: 585 QELAAMEETRIVILNN-LEELKQKIKD----------INDQMDESFRELDMECALLDGEQ 633
+ A+M+ ++ + N LE K+++K ++++ S++ LD+E L
Sbjct: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772
Query: 634 KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAER-EKLERLQELYSEQKTQ 692
++ ++ + + L L + L+KN+ E++K+ ++R E+LE+ + ++ +Q
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNL------EELKISSKRLEQLEKENKSLEQETSQ 826
Query: 693 LDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDE-EKENLTQQLLREV 751
L E ++QL+++ KR +++ E E+ ++ EKEN T L +E+
Sbjct: 827 L----EKDKKQLEKENKRLRQQAEIKDTTLE-------ENNVKIGNLEKENKT--LSKEI 873
Query: 752 AEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEK 809
Y+ + V KE L+K+ +V++A + V + +L+ + ++ +LEK
Sbjct: 874 GIYKESCVRLKE----LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927
Score = 45.8 bits (107), Expect = 3e-04
Identities = 95/470 (20%), Positives = 192/470 (40%), Gaps = 46/470 (9%)
Query: 372 ESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRR 431
E+ R+ T N S ++ E++L+ L + T Q L E K S + +
Sbjct: 764 ENQRLQKTLEN-SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE---------QL 813
Query: 432 QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKI-NKELEKLQLSD 490
++E + EQE +LE+ + + L + + + + T E+ KI N E E LS
Sbjct: 814 EKENKSLEQETSQLEKDKKQ--LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
Query: 491 EESVFEEALMSPDTRYRCHRKDSLPDA--DLASCGSLSQSSASFFTPRSTRNDEL---LS 545
E +++E+ + + K+ + A D+ + +L + S N++L
Sbjct: 872 EIGIYKESCVRLKELEK-ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
Query: 546 DLTRTPPPPSSTFPKASSESSYLSILPKTPEGI---SEEQRSQELAAMEETRIVILNNLE 602
+L + S +L E S E + +++AA+E N +
Sbjct: 931 ELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 990
Query: 603 ELKQKIKDIN------------DQMDESFRELDMECALLDGEQKSETTELMKEKEILDHL 650
+L+Q++K + ++M +S + E + E + T EL+K K+ L +
Sbjct: 991 QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1050
Query: 651 NRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKR 710
R A L+ KT+ K +L+ + L+ Q L +++ Q +L+
Sbjct: 1051 ERNNATLQAEKQALKTQLK-QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ-NAKLQV 1108
Query: 711 DADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISAL-K 769
+ L+ +S + Q L +S L+ E E++ ++ ++ +++ EK+ L +
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE-REDLKSLYDSLIKDHEKLELLHE 1167
Query: 770 KQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKG 819
+QA+ E + + + L + + +LE +Y+ L KG
Sbjct: 1168 RQAS--------EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKG 1209
Score = 40.0 bits (92), Expect = 0.014
Identities = 44/193 (22%), Positives = 94/193 (48%), Gaps = 17/193 (8%)
Query: 585 QELAAMEETRIVILN-NLEELKQKIKDI---NDQMDESFRELDMECALLDGEQKSETTEL 640
+++ +E+ ++++ N N E + + K + ND+++ ++ +L E +L + K+
Sbjct: 1215 EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNL---- 1270
Query: 641 MKEKEILDHLNRKIAELEKNIVGEKTKEKVK-LDAEREKLERLQELYSEQKTQLDNCPES 699
K +L+ N K+ + K KE+ + LD KL EL S+ K L+
Sbjct: 1271 ---KSLLN--NSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1325
Query: 700 MREQLQQQLKRDADLLD--VESKHFEDLEFQQ-LEHESRLDEEKENLTQQLLREVAEYQR 756
+ +Q+Q + ++ LL+ +ESK +E +Q ++ + L +KE L ++++ + Y
Sbjct: 1326 LLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDP 1385
Query: 757 NIVSRKEKISALK 769
+ R+ LK
Sbjct: 1386 SPPRRRGNWITLK 1398
Score = 31.2 bits (69), Expect = 6.5
Identities = 43/224 (19%), Positives = 103/224 (45%), Gaps = 30/224 (13%)
Query: 605 KQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGE 664
++ +K + D + + +L+ LL Q SE L+ + L ++ + E+E + +
Sbjct: 1145 REDLKSLYDSLIKDHEKLE----LLHERQASEYESLISKHGTLKSAHKNL-EVEHRDLED 1199
Query: 665 KTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFED 724
+ + +K + E LE++ ++ E+ + E++ + ++ + L S+ ++
Sbjct: 1200 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1259
Query: 725 LEFQQLEHE--------SRLDEEKENLTQQLLREVAEYQR-NIVSRK-----EKISALK- 769
E Q +H+ S+L++ + L+E +YQ+ +I S K E +S LK
Sbjct: 1260 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE--QYQQLDITSTKLNNQCELLSQLKG 1317
Query: 770 ---KQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810
++ H++ Q Q + +N ++ E ++L ++E++
Sbjct: 1318 NLEEENRHLLDQIQT-----LMLQNRTLLEQNMESKDLFHVEQR 1356
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 61.6 bits (148), Expect = 4e-09
Identities = 102/459 (22%), Positives = 194/459 (42%), Gaps = 88/459 (19%)
Query: 411 ERKSSISSISGRDDLM--DYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS 468
E+ S++ + + + M D R R E + QE+E+ R++LE
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKT-RRKLE------------GDSTD 1059
Query: 469 TGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528
+ ++Q EL K+QL+ +E + AL + +L S +S+
Sbjct: 1060 LSDQIAELQAQIAEL-KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES--QISEL 1116
Query: 529 SASFFTPRSTRN-------------DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTP 575
+ R++RN + L ++L T ++ S ++IL KT
Sbjct: 1117 QEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTL 1176
Query: 576 EGISEEQRSQELAAMEETRIVILNNLEELKQKI---KDINDQMDESFRELDMECALLDGE 632
E EE ++ E A ++E R +EEL +++ K + ++++ + L+ E GE
Sbjct: 1177 E---EEAKTHE-AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE----RGE 1228
Query: 633 QKSETTELMKEKEILDHLNRKI-AELEKNIV----GEK---------TKEKVKLD----- 673
+E L++ K +H +K+ A+L++ V GE+ TK +V+LD
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL 1288
Query: 674 --AEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLE 731
K +L + +S ++QL + E ++E+ +Q+L L VE + E QLE
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE--QLE 1346
Query: 732 HESRLDEEKENLTQQL--------------------LREVAEYQRNIVSRKEKISALKKQ 771
E +E K NL +Q+ L E +R + E +S ++
Sbjct: 1347 EE---EEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEE 1403
Query: 772 ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810
+ ++ + +E ++L++ L ++++ CNLEKK
Sbjct: 1404 KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK 1442
Score = 58.5 bits (140), Expect = 4e-08
Identities = 102/477 (21%), Positives = 195/477 (40%), Gaps = 47/477 (9%)
Query: 394 DLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMER--LERQRLE 451
D +L Q L+E S+S + ++ + E+L E+E + LE+Q +
Sbjct: 1302 DFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQ-IA 1360
Query: 452 TILSLCAEYTKP--DSRLSTGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYRC 508
T+ + A+ K DS T E +K+ K+LE L EE V + L TR +
Sbjct: 1361 TLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ 1420
Query: 509 HRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYL 568
D L D D + SA + + D+LL++ + +A +E+
Sbjct: 1421 ELDDLLVDLDH------QRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474
Query: 569 SILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECAL 628
+ EE Q+ A +E +E+L D + +S EL+
Sbjct: 1475 ETKALSLARALEEAMEQK-AELERLNKQFRTEMEDLMSS----KDDVGKSVHELEKSKRA 1529
Query: 629 LDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSE 688
L+ + + T+L + ++ L LE N+ K + + L E+ E ++
Sbjct: 1530 LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVR 1589
Query: 689 QKTQLDNCPESMREQ----LQQQLKRDADLLDVES-------------KHFEDLEFQQLE 731
Q +++ E R+Q + + K + DL D+E+ K L+ Q +
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649
Query: 732 HESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQ---ANHIVQQAQREQDHFVK 788
LD+ + + +++L + E ++ + S + ++ L+++ A +QAQ+E+D
Sbjct: 1650 CMRELDDTRAS-REEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELAD 1708
Query: 789 E------KNNLIMMLQREKE-NLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEIN 838
E K L + +R E + LE++ G +N + LK+ + +++IN
Sbjct: 1709 EIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTEL-IN-DRLKKANLQIDQIN 1763
Score = 56.6 bits (135), Expect = 1e-07
Identities = 122/643 (18%), Positives = 252/643 (39%), Gaps = 107/643 (16%)
Query: 580 EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTE 639
EE++S+ LA ++ ++ +LEE ++ + +++++ R+L+ + L + +
Sbjct: 1011 EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ 1070
Query: 640 LMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPES 699
+ + K L ++ + E ++ + L RE ++ EL ++ + + +
Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL--QEDLESERASRN 1128
Query: 700 MREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIV 759
E+ ++ L + + L E + D Q E S+ ++E L + L E ++ I
Sbjct: 1129 KAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188
Query: 760 SRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKG 819
++K S ++ ++Q +R + + K K L+ E+ L N + L GKG
Sbjct: 1189 EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT----LENERGELAN---EVKVLLQGKG 1241
Query: 820 FPVNPNTLKEGYISVNEI--NEPCGNSTNLSPS-TQFPADADAVATEPATAVLASQPQSK 876
+ E + ++ NE T L+ T+ + D V L SQ SK
Sbjct: 1242 DSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTG------LLSQSDSK 1295
Query: 877 -----EHFRSLEER--------KKQHKEGLYLSDTLPR-KKTTSSISPHFSSATMGRSIT 922
+ F +LE + ++++++ L LS L + + +S +
Sbjct: 1296 SSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355
Query: 923 PKAHLPL-GQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN----- 976
K L Q + S+ + E +R L+ + + +S+ H +K Y+
Sbjct: 1356 EKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ-KDLEGLSQRHEEKVAAYDKLEKT 1414
Query: 977 --RTASESNVYLNSFHYPDHS-----YKDQAFDTLSLD---------------SSDSMET 1014
R E + L + S K + FD L + +++ E
Sbjct: 1415 KTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474
Query: 1015 SISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESRE------REMEAKKRALE 1068
A S ++ A + + E+ERL KQ E L+ S++ E+E KRALE
Sbjct: 1475 ETKALS---LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531
Query: 1069 EE----KRRREILEKRLQ----------------------------EETSQRQKLI---- 1092
++ K + E LE LQ E++ +++K +
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQV 1591
Query: 1093 -EKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNID 1134
E E ++ + ++ ++ + + + DL +H+++A N D
Sbjct: 1592 REMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD 1634
Score = 49.3 bits (116), Expect = 2e-05
Identities = 94/454 (20%), Positives = 191/454 (42%), Gaps = 42/454 (9%)
Query: 388 VEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMER--L 445
VE +E + L+ Q ++E + + + + E +L++ E E+ L
Sbjct: 924 VEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIIL 983
Query: 446 ERQRLETILSLCAEYTKPDSRLSTGTT-VEDVQKINKELEKLQLSDEESV--FEEALMSP 502
E Q + L E + R++ TT + + ++ +K L KL+ E + EE L
Sbjct: 984 EDQNCK----LAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039
Query: 503 DTRY----RCHRKDSLPDADLAS-CGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSST 557
+ + + RK DL+ L A + + +EL + L R +
Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQK 1099
Query: 558 FPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDIND---- 613
S + + E + E+ S+ A E+ + + LE LK +++D D
Sbjct: 1100 NMALKKIRELESQISELQEDLESERASRNKA--EKQKRDLGEELEALKTELEDTLDSTAA 1157
Query: 614 -QMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKE-KVK 671
Q S RE ++ E++++T E ++ H ++ + EL + + E+TK K
Sbjct: 1158 QQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH-SQAVEELAEQL--EQTKRVKAN 1214
Query: 672 LDAEREKLERLQ-ELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL 730
L+ ++ LE + EL +E K L +S E +++++ L V+ E + +
Sbjct: 1215 LEKAKQTLENERGELANEVKVLLQGKGDS--EHKRKKVEAQLQELQVKFNEGERVRTELA 1272
Query: 731 EHESRLDEEKENLT----------QQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
+ ++L E +N+T +L ++ + + + +E + +Q + + +
Sbjct: 1273 DKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK 1332
Query: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 814
+ +D EKN+ L+ E+E NLEK+ ++L
Sbjct: 1333 QVED----EKNSFREQLEEEEEAKHNLEKQIATL 1362
Score = 47.0 bits (110), Expect = 1e-04
Identities = 87/403 (21%), Positives = 163/403 (40%), Gaps = 50/403 (12%)
Query: 392 EADLESLRQASGTPQPALRERKSSIS-SISGRDDLMDYHRRQREERLREQEMERLERQRL 450
E +L++ A + L+ K+ + GRD+ + ++Q ++RE E E LE +R
Sbjct: 1545 EDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAE-LEDERK 1603
Query: 451 ETILSLCA----EYTKPDSRLSTGTTVEDVQKINKELEKLQ---------LSDEESVFEE 497
+ +++ A E D + ++ + K+L KLQ L D + EE
Sbjct: 1604 QRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREE 1663
Query: 498 ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSST 557
L +K +A++ ++ DEL ++ + S
Sbjct: 1664 ILAQAKEN---EKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANS----SGK 1716
Query: 558 FPKASSESSYLSI-LPKTPEGISEEQRSQEL-------AAMEETRIVILNNLEELK-QKI 608
A E L + + E + EEQ + EL A ++ +I NLE QK
Sbjct: 1717 GALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKN 1776
Query: 609 KDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKE 668
++ Q++ +EL ++ ++G KS K K + L KIA+LE+ + E TKE
Sbjct: 1777 ENARQQLERQNKELKVKLQEMEGTVKS------KYKASITALEAKIAQLEEQLDNE-TKE 1829
Query: 669 KVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQ 728
+ A +++ R ++ + Q+D+ + +Q K AD K + +
Sbjct: 1830 R---QAACKQVRRTEKKLKDVLLQVDD-----ERRNAEQYKDQADKASTRLKQLK----R 1877
Query: 729 QLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQ 771
QLE + ++L RE+ + + ++S+LK +
Sbjct: 1878 QLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920
Score = 46.2 bits (108), Expect = 2e-04
Identities = 108/554 (19%), Positives = 220/554 (39%), Gaps = 71/554 (12%)
Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELM 641
Q EL A E + L KQ++++I ++ E + C L E+K +
Sbjct: 890 QAETELCAEAEE---LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 642 KEKEILDHLN--RKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPES 699
+ +E L+ R+ +LEK K K KL+ E+ LE +++K L++
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLK---KLEEEQIILEDQNCKLAKEKKLLEDRIAE 1003
Query: 700 MREQLQQQLKRDADLLDVESKH---FEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQR 756
L ++ ++ L +++KH DLE ++L E + +E E ++L + +
Sbjct: 1004 FTTNLTEEEEKSKSLAKLKNKHEAMITDLE-ERLRREEKQRQELEKTRRKLEGDSTDLSD 1062
Query: 757 NIVSRKEKISALKKQ---ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSS 813
I + +I+ LK Q +Q A + +KN + ++ + + L++ S
Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLES 1122
Query: 814 LSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAV----L 869
+ N ++ + E E T L + A + ++ V
Sbjct: 1123 ERASR------NKAEKQKRDLGEELEAL--KTELEDTLDSTAAQQELRSKREQEVNILKK 1174
Query: 870 ASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPL 929
+ ++K H ++E +++H + + + + + T + + A K L
Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQA--VEELAEQLEQTKRVKANLEKA--------KQTLEN 1224
Query: 930 GQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQM----SEGHRQKSEFYNRTASESNVY 985
+ V L DSE +R Q++ +EG R ++E ++ ++ V
Sbjct: 1225 ERGELANEV--KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADK-VTKLQVE 1281
Query: 986 LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1045
L++ T L SDS + ++ + S+ +++++ + LL++
Sbjct: 1282 LDNV-------------TGLLSQSDSKSSKLT----KDFSALE----SQLQDTQELLQEE 1320
Query: 1046 HAEKTRL---LESREREMEAKKRALEEEKRRREILEKR---LQEETSQRQKLIEKEVKIR 1099
+ +K L L+ E E + + LEEE+ + LEK+ L + + +K +E V
Sbjct: 1321 NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCL 1380
Query: 1100 ERQRAQARPLTRYL 1113
E R L + L
Sbjct: 1381 ETAEEVKRKLQKDL 1394
Score = 32.3 bits (72), Expect = 2.9
Identities = 25/109 (22%), Positives = 53/109 (48%), Gaps = 9/109 (8%)
Query: 1037 EMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEV 1096
++ R ++ A++ L++ RE+++ A+ R E E L+ +L E Q Q+ ++ E
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTE-----METLQSQLMAEKLQLQEQLQAET 893
Query: 1097 KI-RERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEK 1144
++ E + +AR + + + DL + VE + C H+ +K
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVE---EEEERCQHLQAEKK 939
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 61.6 bits (148), Expect = 4e-09
Identities = 135/713 (18%), Positives = 274/713 (38%), Gaps = 93/713 (13%)
Query: 406 QPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEY----T 461
Q + R K S+ DDL+ RQ EE++ + ++RL+T S +Y T
Sbjct: 918 QSSQRTGKGQPSNKEDVDDLVS-QLRQTEEQVNDL------KERLKTSTSNVEQYQAMVT 970
Query: 462 KPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS 521
+ L+ V + + N E+ + ++ ++ E+ LM + K L D +
Sbjct: 971 SLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKE-----KQELQDDKRRA 1025
Query: 522 CGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEE 581
S+ Q + S+ +E+ L R S+ + + + + +
Sbjct: 1026 IESMEQQLSELKKTLSSVQNEVQEALQRASTALSN------EQQARRDCQEQAKIAVEAQ 1079
Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELM 641
+ + + + L +E K+ + ++E+ ++ + + LL+ + E E M
Sbjct: 1080 NKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ--LLECKASWEERERM 1137
Query: 642 KEKEI------LDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDN 695
+ E+ + L ++ L I EK +KV + L SE+ +
Sbjct: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQI--EKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQ 1195
Query: 696 CPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQ 755
E +R ++R+ ++ + FE + + L + R++ L RE+ E Q
Sbjct: 1196 ILEILRF-----IRREKEIAETR---FEVAQVESLRYRQRVE--------LLERELQELQ 1239
Query: 756 RNIVSRKEKISALKK-QANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 814
++ + +EK+ K A H + E + V E N ML+ EKE L E+ +
Sbjct: 1240 DSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNK---MLREEKERL---EQDLQQM 1293
Query: 815 SGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ-- 872
L+ + + E N + + + + + D + L SQ
Sbjct: 1294 QA------KVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQK 1347
Query: 873 -PQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQ 931
P ++E+ + L E++ K L++ + R K + I+ +S T +++ L +
Sbjct: 1348 DPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLK--AEIARSNASLTNNQNLIQSLKEDLNK 1405
Query: 932 SNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHY 991
+ + L A D + + Q G R K+++ A +
Sbjct: 1406 VRTEKETIQKDLDAKIIDIQEKVKTIT---QVKKIGRRYKTQYEELKAQQ---------- 1452
Query: 992 PDHSYKDQAFDTLSLDSSDSMETSISACS----PDNISSASTSNIARIEEMERLLKQAHA 1047
D+ +T + S D E +S + ++ A T + + ++E L K
Sbjct: 1453 ------DKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSE 1506
Query: 1048 EKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRE 1100
++T +E+ ++ + E R R+ L+ R +E RQ++ EKE K R+
Sbjct: 1507 KETEARNLQEQTVQLQS----ELSRLRQDLQDRTTQEEQLRQQITEKEEKTRK 1555
Score = 50.4 bits (119), Expect = 1e-05
Identities = 109/562 (19%), Positives = 221/562 (39%), Gaps = 88/562 (15%)
Query: 395 LESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETIL 454
L L +A G +R+ + S + IS +++ H R E + + QRL L
Sbjct: 504 LMELEEARGNH--VIRDEEVSSADISSSSEVISQHLVS----YRNIEELQQQNQRLLVAL 557
Query: 455 SLCAEYTKPDSRLSTGTTVEDVQ-KINK---ELEKLQLSDEESV-FEEALMSPDTRYRCH 509
E + + + +T + + ++Q K+ ELE+L+ S + + ++++ YR
Sbjct: 558 RELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRIL 617
Query: 510 RKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP-PSSTFPKASSESSYL 568
+ A SL S + TP+ + +S TP P P +A + L
Sbjct: 618 LSQTTGVAIPLHASSLDDVSLAS-TPKRPSTSQTVS----TPAPVPVIESTEAIEAKAAL 672
Query: 569 SILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDM---- 624
L + E +E+ E E+ LE+L++++ D+ Q + +LD
Sbjct: 673 KQLQEIFENYKKEKAENEKIQNEQ--------LEKLQEQVTDLRSQNTKISTQLDFASKR 724
Query: 625 -------------ECALLDGEQKSETTELMKEKEILDHL-------NRKIAELE---KNI 661
E L + T K+++I++ + N K+A E +N+
Sbjct: 725 YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
Query: 662 VGEKTKEK---VKLDAEREKL---ERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLL 715
EK K V+L +RE L +R Q L + E + +Q+L + L
Sbjct: 785 KKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKL 844
Query: 716 DVESKHFE---------------DLEFQ------QLEHESRLDEEKENLTQQLLREVAEY 754
+ E H + +L+ Q QL+ E+ L + L + +E+A
Sbjct: 845 EHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATL 904
Query: 755 QRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNL-EKKYSS 813
++++ + + ++++ Q Q + +E + ++L+ L++ +E + +L E+ +S
Sbjct: 905 KQHLSNMEVQVASQSSQRTGKGQPSNKE------DVDDLVSQLRQTEEQVNDLKERLKTS 958
Query: 814 LSGGKGFPVNPNTLKEGYISVNEINEPCGNS--TNLSPSTQFPADADAVATEPATAVLAS 871
S + + +L+E ++ E + L S +F + E
Sbjct: 959 TSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQEL 1018
Query: 872 QPQSKEHFRSLEERKKQHKEGL 893
Q + S+E++ + K+ L
Sbjct: 1019 QDDKRRAIESMEQQLSELKKTL 1040
Score = 50.4 bits (119), Expect = 1e-05
Identities = 75/415 (18%), Positives = 183/415 (44%), Gaps = 38/415 (9%)
Query: 397 SLRQASGTPQPA-LRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRL-ETIL 454
S Q TP P + E +I + + L + ++E+ ++++ + ++L E +
Sbjct: 646 STSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVT 705
Query: 455 SLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 514
L ++ TK ++L + ++ + N E + +++ S+ E T + + +
Sbjct: 706 DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREIT---SLHERNQKLTATTQKQEQIINT 762
Query: 515 PDADLASCGSLSQSSASFFTPRSTRNDELLSDLT--RTPPPPSSTFPKASSESSYLSILP 572
DL G+ + + + + + ++ + L+ R S + ++ L+ L
Sbjct: 763 MTQDLR--GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL- 819
Query: 573 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 632
+T +GI E ++ + + + + LK+K+++ +Q R LD++ +
Sbjct: 820 QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQ 879
Query: 633 QKSETTELMKEKEILDHLNRKIAELEKNI------VGEKTKEKV-------KLDAE---- 675
+ET + KE+L + ++IA L++++ V ++ ++ K D +
Sbjct: 880 LDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVS 939
Query: 676 --REKLERLQELYSEQKTQLDNCP--ESMREQLQQQLKRDADLLD-----VESKHFEDLE 726
R+ E++ +L KT N ++M L++ L ++ + + +E + E E
Sbjct: 940 QLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAE 999
Query: 727 FQ-QLEHE-SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQA 779
FQ QLE + +++EK+ L R + ++ + K+ +S+++ + +Q+A
Sbjct: 1000 FQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRA 1054
Score = 48.5 bits (114), Expect = 4e-05
Identities = 145/712 (20%), Positives = 266/712 (37%), Gaps = 110/712 (15%)
Query: 430 RRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLS 489
+RQREE R Q+ +LE + + + + ++V +++ N+ +E +Q+
Sbjct: 438 KRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSV--LERDNRRME-IQVK 494
Query: 490 DEESVFEEALMSPDTRYRCH--RKDSLPDADLASCGS-LSQSSASFFTPRSTRNDELLSD 546
D LM + H R + + AD++S +SQ S+ RN E L
Sbjct: 495 DLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSY------RNIEELQQ 548
Query: 547 LTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQ 606
L L + E E++ + + E ++ + + L EL+Q
Sbjct: 549 ----------------QNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQ 592
Query: 607 KIKDINDQM---DESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVG 663
K QM D R+ DM LL S+TT + + +A K
Sbjct: 593 LRKSRQHQMQLVDSIVRQRDMYRILL-----SQTTGVAIPLHASSLDDVSLASTPKRPST 647
Query: 664 EKTK---------EKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADL 714
+T E + + L++LQE++ K + + EQL++ ++ DL
Sbjct: 648 SQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDL 707
Query: 715 LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVS---RKEKISALKKQ 771
+K L+F +E D V Y+R I S R +K++A ++
Sbjct: 708 RSQNTKISTQLDFASKRYEMLQD------------NVEGYRREITSLHERNQKLTATTQK 755
Query: 772 ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGY 831
I+ ++ ++ N + + + ENL EK+ LS V + +E
Sbjct: 756 QEQIINTMTQD----LRGANEKLAVAEVRAENL-KKEKEMLKLS-----EVRLSQQRESL 805
Query: 832 ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKE 891
++ E G + L+ + TE L+SQ + EH + KK+ +
Sbjct: 806 LA-----EQRGQNLLLTNLQTIQGILERSETETKQR-LSSQIEKLEH--EISHLKKKLEN 857
Query: 892 GLYLSDTLPR----------KKTTSSISPHFSSATMGRS-----ITPKAHLPLGQSNSCG 936
+ TL R ++ + + H ++ + ++ T K HL SN
Sbjct: 858 EVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHL----SNMEV 913
Query: 937 SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNR-TASESNVYLNSFHYPDHS 995
V S K S + Q+ + Q ++ R S SNV
Sbjct: 914 QVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNV----------- 962
Query: 996 YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLES 1055
+ QA T SL+ S + E ++ NI + ++E+ L + EK L +
Sbjct: 963 EQYQAMVT-SLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDD 1021
Query: 1056 REREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQAR 1107
+ R +E+ ++ L E K+ ++ +QE + + E + R + QA+
Sbjct: 1022 KRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK 1073
Score = 48.1 bits (113), Expect = 5e-05
Identities = 50/230 (21%), Positives = 94/230 (40%), Gaps = 48/230 (20%)
Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELM 641
++++EL ++ I I + K++++ + + L E L + K +L
Sbjct: 94 EKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLK 153
Query: 642 KEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMR 701
+ L K+ EL+ + V K +EK +LE+ +EL Q T L+
Sbjct: 154 ESNTTKGELQLKLDELQASDVSVKYREK--------RLEQEKELLHSQNTWLNT------ 199
Query: 702 EQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSR 761
+LK D L L EK N E+ E + N+ ++
Sbjct: 200 -----ELKTKTDEL------------------LALGREKGN-------EILELKCNLENK 229
Query: 762 KEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKY 811
KE++S L++Q N + + +H K +L+ L+ KE ++E+K+
Sbjct: 230 KEEVSRLEEQMNGL----KTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF 275
Score = 42.4 bits (98), Expect = 0.003
Identities = 46/201 (22%), Positives = 90/201 (44%), Gaps = 17/201 (8%)
Query: 578 ISEEQRSQELAAMEETRIVILNNLEELKQKIKDIND----QMDESFRELDMECALLDGEQ 633
+ E Q +E ET+ L + E QK + + E +L E + L +
Sbjct: 1473 VQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDL 1532
Query: 634 KSETTELMKEKEILDHLNRKIAELEKNIVGEKTK------EKVKLDAEREKLERLQELYS 687
+ TT+ E+++ + K + K IV K+K K +L E E+L++
Sbjct: 1533 QDRTTQ---EEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALD 1589
Query: 688 EQKTQLDNCPESMREQLQQQLKR-DADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQ 746
+QK +LD +++ Q + ++ R + +L + + +H E + Q E +++ E++ +T
Sbjct: 1590 QQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQ-EPSNKVPEQQRQIT-- 1646
Query: 747 LLREVAEYQRNIVSRKEKISA 767
L A +R I S + +A
Sbjct: 1647 LKTTPASGERGIASTSDPPTA 1667
Score = 37.4 bits (85), Expect = 0.091
Identities = 87/416 (20%), Positives = 155/416 (37%), Gaps = 77/416 (18%)
Query: 689 QKTQLDNCPESMREQLQQQLKRDADLLD-VESKHFE---DLEFQQLEHESRLDEEKENLT 744
++T+L+ P+S++ +L++ L +D ++ +H + + E Q E E RL +E L
Sbjct: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69
Query: 745 QQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE---QDHFVKEKNNLIMMLQREK 801
+ RE + + ++ AL ++ + R Q F + K L+ EK
Sbjct: 70 NE-TRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEE----LEAEK 124
Query: 802 ENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVA 861
+L ++ S L+ V +NE S Q D
Sbjct: 125 RDLIRTNERLS------------QELEYLTEDVKRLNEKLKESNTTKGELQLKLD----- 167
Query: 862 TEPATAVLASQPQSKEHFRSLEERKK-QHKEGLYLSDTLPRKKTTSSISPHFSSATMGRS 920
+ AS K + LE+ K+ H + +L+ L K T +
Sbjct: 168 -----ELQASDVSVKYREKRLEQEKELLHSQNTWLNTEL--KTKTDEL------------ 208
Query: 921 ITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKS-EFYNRTA 979
L LG+ +L K E R+ N + S H QK E
Sbjct: 209 ------LALGREKG-NEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKL 261
Query: 980 SESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIAR-IEEM 1038
E+ S H+ L++ + + + D S A ++ + R +EE+
Sbjct: 262 KEAKEQQASMEEKFHN---------ELNAHIKLSNLYKSAADD--SEAKSNELTRAVEEL 310
Query: 1039 ERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK--RLQEETSQRQKLI 1092
+LLK+A E + ++ E+E K +E +E+LEK RL++E L+
Sbjct: 311 HKLLKEA-GEANKAIQDHLLEVEQSKDQME-----KEMLEKIGRLEKELENANDLL 360
Score = 36.2 bits (82), Expect = 0.20
Identities = 89/445 (20%), Positives = 173/445 (38%), Gaps = 56/445 (12%)
Query: 409 LRERKSSISSISGRDDLMDYHRRQR----EERLREQEMERLERQRLETILSLCAEYTKPD 464
L +++S I + GR + Q+ E+RL + ERL + E SL E K +
Sbjct: 29 LADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQ-ERLVNETREC-QSLRLELEKLN 86
Query: 465 SRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGS 524
++L T + NKELE ++ + ++ A+ S TR + + DL
Sbjct: 87 NQLKALT------EKNKELE---IAQDRNI---AIQSQFTRTK--EELEAEKRDLIRTNE 132
Query: 525 LSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS 584
+ T R +E L + T + + + K E E S
Sbjct: 133 RLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHS 192
Query: 585 Q-------------ELAAMEETR----IVILNNLEELKQKIKDINDQMD-----ESFREL 622
Q EL A+ + + + NLE K+++ + +QM+ +
Sbjct: 193 QNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQK 252
Query: 623 DMECALLDGEQKSETTELMKEK---EILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKL 679
+E L ++ E M+EK E+ H+ K++ L K+ + + +L E+L
Sbjct: 253 HVEDLLTKLKEAKEQQASMEEKFHNELNAHI--KLSNLYKSAADDSEAKSNELTRAVEEL 310
Query: 680 ERLQELYSEQKTQLDNC---PESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRL 736
+L + E + + E ++Q+++++ L+ E ++ DL + L
Sbjct: 311 HKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAIL 370
Query: 737 DEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIV------QQAQREQDHFVKEK 790
EE+ VA+ + + E +A + + ++ ++ + D VKE
Sbjct: 371 SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV 430
Query: 791 NNLIMMLQREKENLCNLEKKYSSLS 815
+L+R++E +K +SLS
Sbjct: 431 EAKAPILKRQREEYERAQKAVASLS 455
Score = 33.5 bits (75), Expect = 1.3
Identities = 57/318 (17%), Positives = 120/318 (37%), Gaps = 30/318 (9%)
Query: 410 RERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLST 469
+ R + S D +Y + E+ + + +++L E I L AE + ++ L+
Sbjct: 1336 KARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLT----EEIGRLKAEIARSNASLTN 1391
Query: 470 GTTV-----EDVQKINKELEKLQLSDEESVFE--------EALMSPDTRYRCH------R 510
+ ED+ K+ E E +Q + + + + RY+ +
Sbjct: 1392 NQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQ 1451
Query: 511 KDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSI 570
+D + + S G + S EL L + S + + LS
Sbjct: 1452 QDKVMETSAQSSGDHQEQHVSV-----QEMQELKETLNQAETKSKSLESQVENLQKTLSE 1506
Query: 571 LPKTPEGISEE--QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECAL 628
+ E+ Q EL+ + + E+L+Q+I + ++ ++ + A
Sbjct: 1507 KETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAH 1566
Query: 629 LDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSE 688
L G + T E + K+ L+++ EL+ I K++ + ++ +L QE + E
Sbjct: 1567 LAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLE 1626
Query: 689 QKTQLDNCPESMREQLQQ 706
Q+ + + EQ +Q
Sbjct: 1627 QRDEPQEPSNKVPEQQRQ 1644
Score = 31.2 bits (69), Expect = 6.5
Identities = 27/107 (25%), Positives = 48/107 (44%), Gaps = 7/107 (6%)
Query: 1010 DSMETSISACSPDN--ISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRAL 1067
+ + + A + N + A NIA + R ++ AEK L+ + ER + +
Sbjct: 83 EKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLT 142
Query: 1068 EEEKRRREILEKRLQEETSQRQKLIEKE-----VKIRERQRAQARPL 1109
E+ KR E L++ + + KL E + VK RE++ Q + L
Sbjct: 143 EDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKEL 189
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 61.2 bits (147), Expect = 6e-09
Identities = 124/702 (17%), Positives = 289/702 (41%), Gaps = 127/702 (18%)
Query: 475 DVQKINKELEKLQLS------DEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528
+++++N+ELE+++++ + FE A+ D G ++Q
Sbjct: 170 EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRD-------------------GIITQL 210
Query: 529 SASFFTPRSTRNDELLSDLTRTPPPP-----------SSTFPKASSESSYLSILPKTPEG 577
+A+ R +++ + L T S T ++ S+ +L +
Sbjct: 211 TANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQI 270
Query: 578 ISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSET 637
++ +Q+ +E + LE+ ++K +D Q+ SF + ++ ++ ++K E
Sbjct: 271 LTHQQQLEEQDHL----------LEDYQKKKEDFTMQI--SFLQEKIKVYEMEQDKKVEN 318
Query: 638 T---ELMKEKEILDHLNRKIAELEKNIVGEKTK----EKVKLDAEREKLERLQELYSEQK 690
+ E+ +++ I++ LN KI E EK + K K +K+ + + + +++ QE+ K
Sbjct: 319 SNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEI-KNMK 377
Query: 691 TQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLRE 750
+L N + R+ ++ + + +++ ++ +D +F+ + R+++E + +QL E
Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET-DIVQRMEQETQRKLEQLRAE 436
Query: 751 VAE-YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEK 809
+ E Y + IV K+++ H+ Q + M R K + N +
Sbjct: 437 LDEMYGQQIVQMKQELIR-----QHMAQMEE---------------MKTRHKGEMENALR 476
Query: 810 KYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVL 869
YS+++ VN + +K +++NE+N ++ S + + + E
Sbjct: 477 SYSNIT------VNEDQIKLMNVAINELNIKLQDTN--SQKEKLKEELGLILEEKCALQR 528
Query: 870 ASQPQSKEHFRSLEE----RKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKA 925
+ +E S E+ R+ ++ L++ T + SA+ R
Sbjct: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588
Query: 926 H----------LPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFY 975
H L + + +VL + + E R ++H++ ++ E
Sbjct: 589 HEAEVTNYKIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647
Query: 976 NRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTS---NI 1032
+R E HY Q D L + S +ET DN+ + I
Sbjct: 648 HRINIEKLKDNLGIHYK------QQIDGLQNEMSQKIETM--QFEKDNLITKQNQLILEI 699
Query: 1033 ARIEEMERLLKQAHAEKTRL-----------LESREREMEAKKRALEEEKRRREILEKRL 1081
++++++++ L + +E+ L L E+E ++ ++E + + E+LEK++
Sbjct: 700 SKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQM 759
Query: 1082 QE-ETSQRQKLIEKEVK---IRERQRAQARPLTRYLPVRKED 1119
+E E ++K + E + +++ ++ L + PV +E+
Sbjct: 760 KEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEE 801
Score = 61.2 bits (147), Expect = 6e-09
Identities = 136/702 (19%), Positives = 275/702 (39%), Gaps = 90/702 (12%)
Query: 422 RDDLMDYHRRQREERLREQEMER-------LERQRLETILSLCAEYTKPDSRLSTGTTVE 474
RDDL Q++ + E ++E LE+++ ++ L + + +L
Sbjct: 2016 RDDL------QKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069
Query: 475 DVQKINKELEKLQLSDEESVFEEAL-----MSPDTRYRCHRKDSLPD---ADLASCGSLS 526
D Q I++E E+ E E+ L P + ++ + L + C L
Sbjct: 2070 DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129
Query: 527 QSSASFFTPRSTRNDEL------LSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISE 580
S RN+E+ + +L + + TF K + ++ K PE E
Sbjct: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK-PELSLE 2188
Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640
Q E A++ I NLEE ++ ++ + +E ++L M+ + QK E+T
Sbjct: 2189 VQLQAERDAIDRKEKEI-TNLEEQLEQFREELENKNEEVQQLHMQLEI----QKKESTTR 2243
Query: 641 MKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESM 700
++E E + L + ++EK + K + + + + ++ E++ ++D E +
Sbjct: 2244 LQELEQENKLFKD--DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV 2301
Query: 701 REQLQQQLKRDADLLDVESKH--FEDLEFQ---QLEHESRLDEEKENLTQQLLREVAEYQ 755
+ LQQQLK D +E K+ DLE Q + + + +E +QL + + Q
Sbjct: 2302 TK-LQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQ 2360
Query: 756 RNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS 815
+ + + +K S + + + D + EK L ++ E + ++ +
Sbjct: 2361 QELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETN 2420
Query: 816 GGKGFPVNPNT-----LKEGYISVNEINEPCGNSTNLSPS--TQFPADADAVATEPATAV 868
F +N T LK SV +I NS N++ ++ + + V TE A
Sbjct: 2421 ----FKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKS 2476
Query: 869 LASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLP 928
L +++ +F+S +++ +G ++ + S++S T
Sbjct: 2477 L----ENQTYFKSF----EENGKGSIINLETRLLQLESTVSAKDLELTQ----------- 2517
Query: 929 LGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNS 988
KD + + Q+ ++ E A S + L +
Sbjct: 2518 --------------CYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEA 2563
Query: 989 FHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAE 1048
+++ Q T+S + + +++ D + S ++ RI E+E + + H
Sbjct: 2564 VQ--EYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMH-- 2619
Query: 1049 KTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1090
T L+ +E+ A+K LE+EK+ E+ + E QR+K
Sbjct: 2620 -TSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK 2660
Score = 57.4 bits (137), Expect = 8e-08
Identities = 65/275 (23%), Positives = 126/275 (45%), Gaps = 46/275 (16%)
Query: 581 EQRSQELAAMEETRIVILNNLEELK---QKIKDINDQMDESFRELDMECALLDGEQKSET 637
++++ + +E+ + N L+EL+ Q+I++ + + + E ++ + ET
Sbjct: 1939 QEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQET 1998
Query: 638 TELMKEK--------EILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQ 689
+LMKEK ++ D L +++ LE ++ + ++ ++ E+EK L +L +Q
Sbjct: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRF---IELEQEKNTELMDL-RQQ 2054
Query: 690 KTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL----------EHESRLDE- 738
L+ E MR+ L +Q DV + + LE QQL EH++R E
Sbjct: 2055 NQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE-QQLKVVPRFQPISEHQTREVEQ 2113
Query: 739 ------EKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ---------QAQREQ 783
EK + +LL + QR+I R E+I L+ + + Q Q ++
Sbjct: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDR 2173
Query: 784 DHF----VKEKNNLIMMLQREKENLCNLEKKYSSL 814
HF K + +L + LQ E++ + EK+ ++L
Sbjct: 2174 KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNL 2208
Score = 53.9 bits (128), Expect = 9e-07
Identities = 122/606 (20%), Positives = 237/606 (39%), Gaps = 111/606 (18%)
Query: 394 DLESLRQAS--GTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 451
+LE+L+Q S G + R SS + +G ++ + E+ +E+E++R
Sbjct: 1659 ELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVE----EQTFKEKELDRKPEDVPP 1714
Query: 452 TILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRK 511
ILS + R + + KI E+ K + EE++ L D +
Sbjct: 1715 EILS--------NERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSS 1766
Query: 512 DSL-----PDADLASCGS------LSQSSASFFTPRSTRND------------ELLSDLT 548
SL +A + SC +S S+ RND EL L
Sbjct: 1767 ASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLV 1826
Query: 549 R-----TPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIV------- 596
R T P + + S + + K E ISE E A + +T ++
Sbjct: 1827 RSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQK 1886
Query: 597 -----ILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETT---ELMKEKEILD 648
L EEL++++ + + ++ EL ++DG +T ++ ++ +I+D
Sbjct: 1887 QEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIID 1946
Query: 649 HLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYS------------------EQK 690
L +++ N + E E+ ++ ERE L R +E ++K
Sbjct: 1947 RLEQELL-CASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEK 2005
Query: 691 TQLDNCPESMREQLQQQLK-----------RDADLLDVESKHFEDLEFQQLEHESRLDEE 739
++ E +R+ LQ+Q+K R +L ++ DL Q E +L++
Sbjct: 2006 LEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKM 2065
Query: 740 KENLTQQLL-----REV-------AEYQRNIVSRKEKIS-----ALKKQANHIVQQAQRE 782
++ L +Q + R+V E Q +V R + IS +++ ANH+ ++ +
Sbjct: 2066 RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKC 2125
Query: 783 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 842
+ + K L +Q E + LE + L + V+ +T ++ + +
Sbjct: 2126 SE-LLLSKEQLQRDIQERNEEIEKLEFRVRELE--QALLVSADTFQK--VEDRKHFGAVE 2180
Query: 843 NSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRK 902
LS Q A+ DA+ + + + + E FR E K + + L++ + +K
Sbjct: 2181 AKPELSLEVQLQAERDAI--DRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK 2238
Query: 903 KTTSSI 908
++T+ +
Sbjct: 2239 ESTTRL 2244
Score = 51.6 bits (122), Expect = 5e-06
Identities = 101/498 (20%), Positives = 202/498 (40%), Gaps = 95/498 (19%)
Query: 390 FDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLER 447
+ + + S++Q S +P L ERK+ I++IS DL+ + QRE + + Q E
Sbjct: 2965 YSDGEDHSIQQVS---EPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSD 3021
Query: 448 QRLETILSLCAEYTKPDSRL---------STGTT-------------VEDVQKINKELEK 485
R E +L+L + + S L + GTT E + +E
Sbjct: 3022 WRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMEC 3081
Query: 486 LQLSDEESVFEE------ALMSPDTRYRCHRKDSLPDADLASCGSLSQSS--------AS 531
LQ +D S+ E + + ++ P +L + S S
Sbjct: 3082 LQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3141
Query: 532 FFTPRSTRND-----------ELLSDLTRTPPPPSSTFPKASS-----ESSYLSILPKTP 575
R+T EL S+L +T +T E+ L + KT
Sbjct: 3142 SMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTD 3201
Query: 576 EG-------ISEEQRSQELA-AMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECA 627
E SE+++S+EL A+E+ + + + E K++++D+ + ES ++ +++
Sbjct: 3202 EVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSL-ESQKQRNLQLN 3260
Query: 628 LL---------DGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVK-----LD 673
LL + +QK E+ ++ + ++ + R LE ++ E K +++ LD
Sbjct: 3261 LLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGR---NLELQVLLESEKVRIREMSSTLD 3317
Query: 674 AEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHE 733
ERE +LQ +++ E + ++LQ+QL E KH +E +
Sbjct: 3318 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL---------EEKHSRIVELLNETEK 3368
Query: 734 SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNL 793
+LD + T+Q + + + R + +++ + ++ H +Q + ++EK
Sbjct: 3369 YKLDSLQ---TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
Query: 794 IMMLQREKENLCNLEKKY 811
+ L E + L + +++
Sbjct: 3426 VYKLDLEGQRLQGIMQEF 3443
Score = 50.4 bits (119), Expect = 1e-05
Identities = 80/453 (17%), Positives = 196/453 (43%), Gaps = 51/453 (11%)
Query: 388 VEFDEADLESLRQASGTPQPALRERKSSISSISG-RDDLMDYHRRQREERLREQ------ 440
+ F ++ RQ + L E S+S++ + +++ ++E L+ +
Sbjct: 537 LSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNY 596
Query: 441 --EMERLERQRLETILSLCAEYTKPD-SRLSTGTTVEDVQKINKELEKLQLSDEESVFEE 497
++E LE+++ +L AE + + RL T ++++K E L++ ++ E+
Sbjct: 597 KIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINI-EK 654
Query: 498 ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSST 557
+ Y+ + D L + ++ + T + ++L+ ++++ S
Sbjct: 655 LKDNLGIHYK-QQIDGLQNEMSQKIETMQFEKDNLIT----KQNQLILEISKLKDLQQSL 709
Query: 558 FPKASSESSY-LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMD 616
S E + ++ L K E + +E++ + E + + L L++++K+ + +
Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL--LEKQMKEKENDLQ 767
Query: 617 ESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAER 676
E F +L+ E ++L E+K+ +++K ++ +++ E+ I + K K K
Sbjct: 768 EKFAQLEAENSILKDEKKT-LEDMLK-------IHTPVSQEERLIFLDSIKSKSKDSVWE 819
Query: 677 EKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHE-SR 735
+++E L E + K Q QL +++++ + K+FE + +Q+L+ E +
Sbjct: 820 KEIEILIEENEDLKQQC--------IQLNEEIEKQRNTFSFAEKNFE-VNYQELQEEYAC 870
Query: 736 LDEEKENLTQQLLREVAEYQRNIVSRKEKI-------------SALKKQANHIVQQAQRE 782
L + K++L ++ EY+ + + E++ S++ + V +
Sbjct: 871 LLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEM 930
Query: 783 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS 815
+ K+ L+ L+ K L ++ S LS
Sbjct: 931 GEVVEKDTTELMEKLEVTKREKLELSQRLSDLS 963
Score = 46.6 bits (109), Expect = 1e-04
Identities = 100/565 (17%), Positives = 220/565 (38%), Gaps = 70/565 (12%)
Query: 555 SSTFPKASSESSYLSILPKT--PEGISEEQR-------SQELAAMEETRIVILNN-LEEL 604
S+T SSE + S + +T P + E+ S++ A T + ++ + L
Sbjct: 108 STTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGK 167
Query: 605 KQKIKDINDQMDE-----------SFRELDMECALLDGEQKSETTELMKEKEILDHLNRK 653
+ +I+++N +++E +E + DG T L + + D R+
Sbjct: 168 QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMRE 227
Query: 654 IAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQL---QQQLKR 710
EL T++ KL + ++L+ + L + + ++Q+ QQQL+
Sbjct: 228 FLEL--------TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 279
Query: 711 DADLLDVESKHFEDLEFQ-----------QLEHESRLD-------EEKENLTQQLLREVA 752
LL+ K ED Q ++E + +++ +EKE + ++L ++
Sbjct: 280 QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKII 339
Query: 753 EYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYS 812
E ++ + K+K++ K + +Q ++ K L Q+E+++ +++
Sbjct: 340 EEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMG 399
Query: 813 SLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ 872
++ + K+ + + Q A+ D + + V Q
Sbjct: 400 TVE-----ELQKRNHKDSQFETDIVQRM--EQETQRKLEQLRAELDEMYGQ--QIVQMKQ 450
Query: 873 PQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQS 932
++H +EE K +HK + ++ S+I+ + + + ++ L +
Sbjct: 451 ELIRQHMAQMEEMKTRHK-----GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDT 505
Query: 933 NSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYP 992
NS L L + ++ + + +++S R++ + +T +E LN H
Sbjct: 506 NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS-REQIQRARQTIAEQESKLNEAHKS 564
Query: 993 DHSYKDQAFDTLSL-DSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAE--- 1048
+ +D + +S +S +E A + + ++R+ + AE
Sbjct: 565 LSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELER 624
Query: 1049 -KTRLLESREREMEAKKRALEEEKR 1072
+T+LL S E E+ K LE E R
Sbjct: 625 LRTQLLFSHEEELSKLKEDLEIEHR 649
Score = 42.4 bits (98), Expect = 0.003
Identities = 56/246 (22%), Positives = 110/246 (44%), Gaps = 53/246 (21%)
Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640
+++ Q M + +IV L + E K ++ E+ +E C Q ++T
Sbjct: 2526 QEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFC------QDNQTISS 2579
Query: 641 MKEKEILDHLNR---------------KIAELEKNIVGEKT-----KEKVKLDAEREKLE 680
E+ + +LN+ +I+ELE +V T KE+V++ AE+ LE
Sbjct: 2580 EPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEI-AEKNVLE 2638
Query: 681 RLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV---------ESKHFEDLEFQQLE 731
+ ++L QK L+ + RE+ +++ +D ++L ES F +LE + E
Sbjct: 2639 KEKKLLELQKL-LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE 2697
Query: 732 HES-------------RLDEE---KENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI 775
+ +L EE KE L +++++ + ++ KEK+S L+K+
Sbjct: 2698 SVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE 2757
Query: 776 VQQAQR 781
VQ++++
Sbjct: 2758 VQESKK 2763
Score = 41.6 bits (96), Expect = 0.005
Identities = 84/429 (19%), Positives = 161/429 (37%), Gaps = 106/429 (24%)
Query: 431 RQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKL--QL 488
+Q E LR+ M ++ERQR ED +++ +E+++L QL
Sbjct: 1602 QQATELLRQAHMRQMERQR------------------------EDQEQLQEEIKRLNRQL 1637
Query: 489 SDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASFFTPRSTRNDELL 544
+ S+ E L+S R ++L LA C L SS T N +
Sbjct: 1638 AQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ--TQNGNENQGEV 1695
Query: 545 SDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEEL 604
+ TF + L + PE + E S E A+++ +L L E+
Sbjct: 1696 EE---------QTFKEKE--------LDRKPEDVPPEILSNERYALQKANNRLLKILLEV 1738
Query: 605 KQKIKDINDQ--------MDESFRELDMECALLDGEQKSETTELMKE-------KEILDH 649
+ + + +D S + + E ++ + E + I +
Sbjct: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798
Query: 650 LNRKIAELEKNIVGEKTKEKVKL--------------DAEREKL------------ERLQ 683
+ + N+ + T+E +L D E E+L E+L
Sbjct: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLL 1858
Query: 684 ELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEE---- 739
E SE +QL++ + E +++ ++ + ES ++ ++L ESR E+
Sbjct: 1859 EAISETSSQLEHAKVTQTELMRESFRQKQEA--TESLKCQEELRERLHEESRAREQLAVE 1916
Query: 740 ---KENLTQQLLREVAEYQRNIVSRKEKISALKKQ---ANHIVQQAQREQDHFVKEKNNL 793
E + E ++R I + + I L+++ A++ +Q+ + EQ +E+
Sbjct: 1917 LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE-- 1974
Query: 794 IMMLQREKE 802
+L R+KE
Sbjct: 1975 --LLSRQKE 1981
Score = 40.8 bits (94), Expect = 0.008
Identities = 75/349 (21%), Positives = 140/349 (40%), Gaps = 45/349 (12%)
Query: 474 EDVQKINKE--LEKLQLSDEESV-FEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSA 530
E QKI + L QLS+E+ E ++ + R S D + L S
Sbjct: 3272 ESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3331
Query: 531 SFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS---QEL 587
+ + +++LL +L + S + +E+ + E+ R + L
Sbjct: 3332 TGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTL 3391
Query: 588 AAMEETRIVILNNLEELKQKIKDINDQMDESFRE---LDMECALLDG------EQKSETT 638
+E + EL+ K++D+ Q++E ++ LD+E L G +Q+ E
Sbjct: 3392 QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3451
Query: 639 ELMKEKEIL-DHLNRKIA-----------ELEKNIVGEKTKEK-----VKLDAE----RE 677
E + + IL +LN L++ I GE TKE ++++
Sbjct: 3452 EKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGE-TKESNYAKLIEMNGGGTGCNH 3510
Query: 678 KLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK------HFEDLEFQQLE 731
+LE +++ ++L P+ E+LQ + D D + V+ + L QQ E
Sbjct: 3511 ELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGE 3570
Query: 732 HESRLDEEKE--NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ 778
S + +LT++LLR+ AE +I E+ + L+ + +Q
Sbjct: 3571 EPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3619
Score = 39.3 bits (90), Expect = 0.024
Identities = 97/488 (19%), Positives = 190/488 (38%), Gaps = 69/488 (14%)
Query: 363 NPSH-----SLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS 417
+P+H S LAG+ + R V + L+ L++ + A+++R I+
Sbjct: 153 SPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEF----EAAIKQRDGIIT 208
Query: 418 SISGRDDLMDYHRRQREERLRE---------------QEMERLERQRLETILSLCAEYTK 462
++ + RR+++E +RE Q+++ E R T S A+ +
Sbjct: 209 QLTAN---LQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQ 265
Query: 463 PDSRLSTGTT--------VEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 514
++ T +ED QK KE +Q+S + + M D + K+ +
Sbjct: 266 AKQQILTHQQQLEEQDHLLEDYQK-KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 324
Query: 515 PDAD-----LASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLS 569
+ + L + + + T D+LL +L + E +
Sbjct: 325 QEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTN-- 382
Query: 570 ILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALL 629
K E S E+ Q + +EE + N ++ + + + E+ R+L+ A L
Sbjct: 383 --SKQKERQSSEEIKQLMGTVEELQ---KRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437
Query: 630 DGEQKSETTELMKEKEILDHL-------NRKIAELEK------NIVGEKTKEKVKLDAER 676
D E + MK++ I H+ R E+E NI + + K+ A
Sbjct: 438 D-EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN 496
Query: 677 EKLERLQELYSEQKTQLDNCPESMREQ--LQQQLKRDADLLDVESKHFEDLEFQQLEHES 734
E +LQ+ S+++ + + E+ LQ+QL+ + L + + E ES
Sbjct: 497 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQES 556
Query: 735 RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLI 794
+L+E ++L+ V + + IVS E L+ + V + + + KEKN ++
Sbjct: 557 KLNEAHKSLST-----VEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611
Query: 795 MMLQREKE 802
+ +E
Sbjct: 612 DRMAESQE 619
Score = 38.5 bits (88), Expect = 0.041
Identities = 100/540 (18%), Positives = 212/540 (39%), Gaps = 72/540 (13%)
Query: 603 ELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN-I 661
+ K++ K ++ ++ E +E+ + S+ ++ + K+ + ++ ++ +K I
Sbjct: 1509 KFKEEFKPLSKELGEHGKEILLS--------NSDPHDIPESKDCVLTISEEMFSKDKTFI 1560
Query: 662 VGEKTKEKVK---LDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV- 717
V + +++ +DA R+ + ++L E MR++L +Q + ++
Sbjct: 1561 VRQSIHDEISVSSMDASRQLMLNEEQL------------EDMRQELVRQYQEHQQATELL 1608
Query: 718 ESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ 777
H +E +Q E + +L EE + L +QL + + N+VS +E++ + +A +
Sbjct: 1609 RQAHMRQME-RQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLS 1667
Query: 778 QAQREQDHFVKEKNNLIMMLQREKENLCNLEK---KYSSLSGGKGFPVNPNTLKEGYISV 834
A RE+ E N Q EN +E+ K L K V P L ++
Sbjct: 1668 LAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELD-RKPEDVPPEILSNERYAL 1724
Query: 835 NEINE------------PCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSL 882
+ N + D + + A+ + S+ ++
Sbjct: 1725 QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVH 1784
Query: 883 EERKKQHKEGL--YLSDTLPR----------KKTTSSISPHFSSATMGRSITPK-AHLPL 929
EE + E + Y +PR ++ T S G I P+ L L
Sbjct: 1785 EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELML 1844
Query: 930 GQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSF 989
S+ + + L A+++ S + + M E RQK E A+ES
Sbjct: 1845 NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQE-----ATESLKCQEEL 1899
Query: 990 HYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEK 1049
H + +A + L+++ S + D + T +I+E ++ + E
Sbjct: 1900 RERLHE-ESRAREQLAVELSKAEGVI------DGYADEKTLFERQIQEKTDIIDRLEQE- 1951
Query: 1050 TRLLESREREMEAKKRALEEEKRRREILEKRLQEETS--QRQKLIEKEVKIRERQRAQAR 1107
+R +E+EA+++ ++EE+ ++ ++ E ++Q L E E ++E+ Q +
Sbjct: 1952 LLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011
Score = 33.1 bits (74), Expect = 1.7
Identities = 32/154 (20%), Positives = 74/154 (48%), Gaps = 22/154 (14%)
Query: 590 MEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDH 649
++E +V N+ L++ + + D + E+ +L ++L+ E ++E E K+ + +
Sbjct: 2715 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKL----SILEKEDETEVQE-SKKACMFEP 2769
Query: 650 LNRKIAELEKNIVGEKTKEKVKLDAEREKLERL-----------QELYSEQKTQLDNCPE 698
L K+++ + +T +K+ + + + L E SE+ T++ +
Sbjct: 2770 LPIKLSKS----IASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFT 2825
Query: 699 SMREQLQQQLKRDADLLDVESKHFEDLEFQQLEH 732
E++Q+ A++LD+ES+H + E + EH
Sbjct: 2826 EKIEKMQEL--HAAEILDMESRHISETETLKREH 2857
Score = 32.7 bits (73), Expect = 2.2
Identities = 80/406 (19%), Positives = 151/406 (37%), Gaps = 64/406 (15%)
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
E+ +E +LN + E K+ + ++ + + + L GE+ L KE+
Sbjct: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEEN-----LPKEET 1302
Query: 646 ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLE-RLQELYSEQKTQLDNCPESMREQL 704
++ ++ LE V K+K D E+ KLE ++QEL ES+ L
Sbjct: 1303 EFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL------------ESLISSL 1350
Query: 705 QQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEK 764
QQQLK + E + ++L+ S ++ ++ QR +
Sbjct: 1351 QQQLKETEQNYEAEIHCLQ----KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPG--- 1403
Query: 765 ISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE-----KENLCNL----------EK 809
S +KK + ++ + + VKE+ N++ +L+++ +E + + +
Sbjct: 1404 -SCVKKNIDGTIEFS---GEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQT 1459
Query: 810 KYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVL 869
+ S +SGG KE S + + C + + D T V
Sbjct: 1460 ELSRISGG----------KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDV- 1508
Query: 870 ASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR-----KKTTSSISPHFSSATMGRSITPK 924
+ KE F+ L + +H + + LS++ P K +IS S +
Sbjct: 1509 ----KFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQS 1564
Query: 925 AHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQ 970
H + S+ S +D + + HQQ +E RQ
Sbjct: 1565 IHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQ 1610
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 61.2 bits (147), Expect = 6e-09
Identities = 124/702 (17%), Positives = 289/702 (41%), Gaps = 127/702 (18%)
Query: 475 DVQKINKELEKLQLS------DEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528
+++++N+ELE+++++ + FE A+ D G ++Q
Sbjct: 170 EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRD-------------------GIITQL 210
Query: 529 SASFFTPRSTRNDELLSDLTRTPPPP-----------SSTFPKASSESSYLSILPKTPEG 577
+A+ R +++ + L T S T ++ S+ +L +
Sbjct: 211 TANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQI 270
Query: 578 ISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSET 637
++ +Q+ +E + LE+ ++K +D Q+ SF + ++ ++ ++K E
Sbjct: 271 LTHQQQLEEQDHL----------LEDYQKKKEDFTMQI--SFLQEKIKVYEMEQDKKVEN 318
Query: 638 T---ELMKEKEILDHLNRKIAELEKNIVGEKTK----EKVKLDAEREKLERLQELYSEQK 690
+ E+ +++ I++ LN KI E EK + K K +K+ + + + +++ QE+ K
Sbjct: 319 SNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEI-KNMK 377
Query: 691 TQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLRE 750
+L N + R+ ++ + + +++ ++ +D +F+ + R+++E + +QL E
Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET-DIVQRMEQETQRKLEQLRAE 436
Query: 751 VAE-YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEK 809
+ E Y + IV K+++ H+ Q + M R K + N +
Sbjct: 437 LDEMYGQQIVQMKQELIR-----QHMAQMEE---------------MKTRHKGEMENALR 476
Query: 810 KYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVL 869
YS+++ VN + +K +++NE+N ++ S + + + E
Sbjct: 477 SYSNIT------VNEDQIKLMNVAINELNIKLQDTN--SQKEKLKEELGLILEEKCALQR 528
Query: 870 ASQPQSKEHFRSLEE----RKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKA 925
+ +E S E+ R+ ++ L++ T + SA+ R
Sbjct: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588
Query: 926 H----------LPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFY 975
H L + + +VL + + E R ++H++ ++ E
Sbjct: 589 HEAEVTNYKIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647
Query: 976 NRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTS---NI 1032
+R E HY Q D L + S +ET DN+ + I
Sbjct: 648 HRINIEKLKDNLGIHYK------QQIDGLQNEMSQKIETM--QFEKDNLITKQNQLILEI 699
Query: 1033 ARIEEMERLLKQAHAEKTRL-----------LESREREMEAKKRALEEEKRRREILEKRL 1081
++++++++ L + +E+ L L E+E ++ ++E + + E+LEK++
Sbjct: 700 SKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQM 759
Query: 1082 QE-ETSQRQKLIEKEVK---IRERQRAQARPLTRYLPVRKED 1119
+E E ++K + E + +++ ++ L + PV +E+
Sbjct: 760 KEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEE 801
Score = 58.2 bits (139), Expect = 5e-08
Identities = 64/267 (23%), Positives = 125/267 (46%), Gaps = 38/267 (14%)
Query: 581 EQRSQELAAMEETRIVILNNLEELK---QKIKDINDQMDESFRELDMECALLDGEQKSET 637
++++ + +E+ + N L+EL+ Q+I++ + + + E ++ + ET
Sbjct: 1939 QEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQET 1998
Query: 638 TELMKEK--------EILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQ 689
+LMKEK ++ D L +++ LE ++ + ++ ++ E+EK L +L +Q
Sbjct: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRF---IELEQEKNTELMDL-RQQ 2054
Query: 690 KTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQL----------EHESRLDE- 738
L+ E MR+ L +Q DV + + LE QQL EH++R E
Sbjct: 2055 NQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE-QQLKVVPRFQPISEHQTREVEQ 2113
Query: 739 ------EKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ-AQREQDHF----V 787
EK + +LL + QR+I R E+I L+ + + Q ++ HF
Sbjct: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEA 2173
Query: 788 KEKNNLIMMLQREKENLCNLEKKYSSL 814
K + +L + LQ E++ + EK+ ++L
Sbjct: 2174 KPELSLEVQLQAERDAIDRKEKEITNL 2200
Score = 57.4 bits (137), Expect = 8e-08
Identities = 114/571 (19%), Positives = 230/571 (40%), Gaps = 91/571 (15%)
Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDE-SFRELDMECALLDGEQK----- 634
EQ + L + +L + E+L++ I++ N+++++ FR ++E ALL ++K
Sbjct: 2112 EQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAV 2171
Query: 635 ------SETTELMKEKEILDHLNRKIAELEKNI------VGEKTKEKVKLDAE-----RE 677
S +L E++ +D ++I LE+ + + K +E +L + +E
Sbjct: 2172 EAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKE 2231
Query: 678 KLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHES--- 734
RLQEL E K D+ E+L +K ++D + + +H +F Q+ E
Sbjct: 2232 STTRLQELEQENKLFKDDM-----EKLGLAIK-ESDAMSTQDQHVLFGKFAQIIQEKEVE 2285
Query: 735 --RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ---REQDHFVKE 789
+L+E+ L QQL ++ + I + E I L+ Q ++ + R ++ +++
Sbjct: 2286 IDQLNEQVTKLQQQL--KITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2343
Query: 790 KNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISV-NEINEPCGNSTNLS 848
N +I LQ+E N+ G+ +N ++L E S+ ++++ L
Sbjct: 2344 LNEVIEKLQQELANI------------GQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2391
Query: 849 PSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSI 908
+ + Q + SL K+ +E + ++P +I
Sbjct: 2392 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSL----KRERESVEKIQSIPENSVNVAI 2447
Query: 909 SPHFS----------SATMGRSITPKAHLPLGQSNSCGSV-------LPPSLAAMAKDSE 951
H S + +S+ + + + N GS+ L AKD E
Sbjct: 2448 D-HLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLE 2506
Query: 952 SR---RMLRGYNHQQMSEGHRQKSEFYN---------RTASESNVYLNSFHYPDHSYKDQ 999
+ ++ Q E + + N A S + L + +++ Q
Sbjct: 2507 LTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQ--EYAKFCQ 2564
Query: 1000 AFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESRERE 1059
T+S + + +++ D + S ++ RI E+E + + H T L+ +E+
Sbjct: 2565 DNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMH---TSLILEKEQV 2621
Query: 1060 MEAKKRALEEEKRRREILEKRLQEETSQRQK 1090
A+K LE+EK+ E+ + E QR+K
Sbjct: 2622 EIAEKNVLEKEKKLLELQKLLEGNEKKQREK 2652
Score = 54.3 bits (129), Expect = 7e-07
Identities = 125/600 (20%), Positives = 240/600 (40%), Gaps = 107/600 (17%)
Query: 394 DLESLRQAS--GTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 451
+LE+L+Q S G + R SS + +G ++ + E+ +E+E++R
Sbjct: 1659 ELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVE----EQTFKEKELDRKPEDVPP 1714
Query: 452 TILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRK 511
ILS + R + + KI E+ K + EE++ L D +
Sbjct: 1715 EILS--------NERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSS 1766
Query: 512 DSL-----PDADLASCGS------LSQSSASFFTPRSTRND------------ELLSDLT 548
SL +A + SC +S S+ RND EL L
Sbjct: 1767 ASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLV 1826
Query: 549 R-----TPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIV------- 596
R T P + + S + + K E ISE E A + +T ++
Sbjct: 1827 RSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQK 1886
Query: 597 -----ILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETT---ELMKEKEILD 648
L EEL++++ + + ++ EL ++DG +T ++ ++ +I+D
Sbjct: 1887 QEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIID 1946
Query: 649 HLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYS------------------EQK 690
L +++ N + E E+ ++ ERE L R +E ++K
Sbjct: 1947 RLEQELL-CASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEK 2005
Query: 691 TQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKEN--LTQQL- 747
++ E +R+ LQ+Q+K A +DVE + +E +Q ++ +D ++N L +QL
Sbjct: 2006 LEVQCQAEKVRDDLQKQVK--ALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLE 2063
Query: 748 -----LREVA---EYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQR 799
L E A E++R++ +++I L++Q +V + Q +H +E L L +
Sbjct: 2064 KMRKFLDEQAIDREHERDVF--QQEIQKLEQQLK-VVPRFQPISEHQTREVEQLANHL-K 2119
Query: 800 EKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINE-----------PCGNSTNLS 848
EK + C+ E S + +++ V E+ + LS
Sbjct: 2120 EKTDKCS-ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELS 2178
Query: 849 PSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSI 908
Q A+ DA+ + + + + E FR E K + + L++ + +K++T+ +
Sbjct: 2179 LEVQLQAERDAI--DRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 2236
Score = 51.6 bits (122), Expect = 5e-06
Identities = 101/498 (20%), Positives = 202/498 (40%), Gaps = 95/498 (19%)
Query: 390 FDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLER 447
+ + + S++Q S +P L ERK+ I++IS DL+ + QRE + + Q E
Sbjct: 2957 YSDGEDHSIQQVS---EPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSD 3013
Query: 448 QRLETILSLCAEYTKPDSRL---------STGTT-------------VEDVQKINKELEK 485
R E +L+L + + S L + GTT E + +E
Sbjct: 3014 WRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMEC 3073
Query: 486 LQLSDEESVFEE------ALMSPDTRYRCHRKDSLPDADLASCGSLSQSS--------AS 531
LQ +D S+ E + + ++ P +L + S S
Sbjct: 3074 LQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3133
Query: 532 FFTPRSTRND-----------ELLSDLTRTPPPPSSTFPKASS-----ESSYLSILPKTP 575
R+T EL S+L +T +T E+ L + KT
Sbjct: 3134 SMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTD 3193
Query: 576 EG-------ISEEQRSQELA-AMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECA 627
E SE+++S+EL A+E+ + + + E K++++D+ + ES ++ +++
Sbjct: 3194 EVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSL-ESQKQRNLQLN 3252
Query: 628 LL---------DGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVK-----LD 673
LL + +QK E+ ++ + ++ + R LE ++ E K +++ LD
Sbjct: 3253 LLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGR---NLELQVLLESEKVRIREMSSTLD 3309
Query: 674 AEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHE 733
ERE +LQ +++ E + ++LQ+QL E KH +E +
Sbjct: 3310 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL---------EEKHSRIVELLNETEK 3360
Query: 734 SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNL 793
+LD + T+Q + + + R + +++ + ++ H +Q + ++EK
Sbjct: 3361 YKLDSLQ---TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3417
Query: 794 IMMLQREKENLCNLEKKY 811
+ L E + L + +++
Sbjct: 3418 VYKLDLEGQRLQGIMQEF 3435
Score = 50.8 bits (120), Expect = 8e-06
Identities = 89/438 (20%), Positives = 180/438 (41%), Gaps = 59/438 (13%)
Query: 398 LRQASGTPQPALRERKSSISSISGRDDLMDYHRRQ---REERLREQEMERLERQRLETIL 454
L +A G E+ I + D++D ++ RL+E E E+ + Q +L
Sbjct: 1917 LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL 1976
Query: 455 SLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 514
S E K ++ +++ +K+ KE ++Q E+ +D L
Sbjct: 1977 SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKV-----------------RDDL 2019
Query: 515 PDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKT 574
A + + + F +N EL+ DL + K +I +
Sbjct: 2020 QKQVKALEIDVEEQVSRFIELEQEKNTELM-DLRQQNQALEKQLEKMRKFLDEQAIDREH 2078
Query: 575 PEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQK 634
+ + QE+ +E+ V+ + + +++ +Q+ +E +C+ L ++
Sbjct: 2079 ERDVFQ----QEIQKLEQQLKVVPRFQPISEHQTREV-EQLANHLKEKTDKCSELLLSKE 2133
Query: 635 SETTELMKEKEILDHLNRKIAELEKNIVGEKTKE------------KVKLDAEREKLERL 682
++ + E ++ L ++ ELE+ ++ E K +V+L AER+ ++R
Sbjct: 2134 QLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK 2193
Query: 683 QELYSEQKTQLDNCPESMREQLQQQLKRDADL---LDVESKHFEDLEFQQLEHESRL--- 736
+ ++ T L+ E RE+L+ + + L L+++ K Q+LE E++L
Sbjct: 2194 E----KEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKE-STTRLQELEQENKLFKD 2248
Query: 737 DEEKENL---------TQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDH-F 786
D EK L TQ ++ + I ++ +I L +Q + QQ + D+
Sbjct: 2249 DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKV 2308
Query: 787 VKEKNNLIMMLQREKENL 804
++EKN LI L+ + E L
Sbjct: 2309 IEEKNELIRDLETQIECL 2326
Score = 50.4 bits (119), Expect = 1e-05
Identities = 80/453 (17%), Positives = 196/453 (43%), Gaps = 51/453 (11%)
Query: 388 VEFDEADLESLRQASGTPQPALRERKSSISSISG-RDDLMDYHRRQREERLREQ------ 440
+ F ++ RQ + L E S+S++ + +++ ++E L+ +
Sbjct: 537 LSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNY 596
Query: 441 --EMERLERQRLETILSLCAEYTKPD-SRLSTGTTVEDVQKINKELEKLQLSDEESVFEE 497
++E LE+++ +L AE + + RL T ++++K E L++ ++ E+
Sbjct: 597 KIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINI-EK 654
Query: 498 ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSST 557
+ Y+ + D L + ++ + T + ++L+ ++++ S
Sbjct: 655 LKDNLGIHYK-QQIDGLQNEMSQKIETMQFEKDNLIT----KQNQLILEISKLKDLQQSL 709
Query: 558 FPKASSESSY-LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMD 616
S E + ++ L K E + +E++ + E + + L L++++K+ + +
Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL--LEKQMKEKENDLQ 767
Query: 617 ESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAER 676
E F +L+ E ++L E+K+ +++K ++ +++ E+ I + K K K
Sbjct: 768 EKFAQLEAENSILKDEKKT-LEDMLK-------IHTPVSQEERLIFLDSIKSKSKDSVWE 819
Query: 677 EKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHE-SR 735
+++E L E + K Q QL +++++ + K+FE + +Q+L+ E +
Sbjct: 820 KEIEILIEENEDLKQQC--------IQLNEEIEKQRNTFSFAEKNFE-VNYQELQEEYAC 870
Query: 736 LDEEKENLTQQLLREVAEYQRNIVSRKEKI-------------SALKKQANHIVQQAQRE 782
L + K++L ++ EY+ + + E++ S++ + V +
Sbjct: 871 LLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEM 930
Query: 783 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS 815
+ K+ L+ L+ K L ++ S LS
Sbjct: 931 GEVVEKDTTELMEKLEVTKREKLELSQRLSDLS 963
Score = 46.6 bits (109), Expect = 1e-04
Identities = 100/565 (17%), Positives = 220/565 (38%), Gaps = 70/565 (12%)
Query: 555 SSTFPKASSESSYLSILPKT--PEGISEEQR-------SQELAAMEETRIVILNN-LEEL 604
S+T SSE + S + +T P + E+ S++ A T + ++ + L
Sbjct: 108 STTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGK 167
Query: 605 KQKIKDINDQMDE-----------SFRELDMECALLDGEQKSETTELMKEKEILDHLNRK 653
+ +I+++N +++E +E + DG T L + + D R+
Sbjct: 168 QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMRE 227
Query: 654 IAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQL---QQQLKR 710
EL T++ KL + ++L+ + L + + ++Q+ QQQL+
Sbjct: 228 FLEL--------TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 279
Query: 711 DADLLDVESKHFEDLEFQ-----------QLEHESRLD-------EEKENLTQQLLREVA 752
LL+ K ED Q ++E + +++ +EKE + ++L ++
Sbjct: 280 QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKII 339
Query: 753 EYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYS 812
E ++ + K+K++ K + +Q ++ K L Q+E+++ +++
Sbjct: 340 EEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMG 399
Query: 813 SLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ 872
++ + K+ + + Q A+ D + + V Q
Sbjct: 400 TVE-----ELQKRNHKDSQFETDIVQRM--EQETQRKLEQLRAELDEMYGQ--QIVQMKQ 450
Query: 873 PQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQS 932
++H +EE K +HK + ++ S+I+ + + + ++ L +
Sbjct: 451 ELIRQHMAQMEEMKTRHK-----GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDT 505
Query: 933 NSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYP 992
NS L L + ++ + + +++S R++ + +T +E LN H
Sbjct: 506 NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS-REQIQRARQTIAEQESKLNEAHKS 564
Query: 993 DHSYKDQAFDTLSL-DSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAE--- 1048
+ +D + +S +S +E A + + ++R+ + AE
Sbjct: 565 LSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELER 624
Query: 1049 -KTRLLESREREMEAKKRALEEEKR 1072
+T+LL S E E+ K LE E R
Sbjct: 625 LRTQLLFSHEEELSKLKEDLEIEHR 649
Score = 42.4 bits (98), Expect = 0.003
Identities = 56/246 (22%), Positives = 110/246 (44%), Gaps = 53/246 (21%)
Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640
+++ Q M + +IV L + E K ++ E+ +E C Q ++T
Sbjct: 2518 QEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFC------QDNQTISS 2571
Query: 641 MKEKEILDHLNR---------------KIAELEKNIVGEKT-----KEKVKLDAEREKLE 680
E+ + +LN+ +I+ELE +V T KE+V++ AE+ LE
Sbjct: 2572 EPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEI-AEKNVLE 2630
Query: 681 RLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV---------ESKHFEDLEFQQLE 731
+ ++L QK L+ + RE+ +++ +D ++L ES F +LE + E
Sbjct: 2631 KEKKLLELQKL-LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE 2689
Query: 732 HES-------------RLDEE---KENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI 775
+ +L EE KE L +++++ + ++ KEK+S L+K+
Sbjct: 2690 SVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE 2749
Query: 776 VQQAQR 781
VQ++++
Sbjct: 2750 VQESKK 2755
Score = 41.6 bits (96), Expect = 0.005
Identities = 84/429 (19%), Positives = 161/429 (37%), Gaps = 106/429 (24%)
Query: 431 RQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKL--QL 488
+Q E LR+ M ++ERQR ED +++ +E+++L QL
Sbjct: 1602 QQATELLRQAHMRQMERQR------------------------EDQEQLQEEIKRLNRQL 1637
Query: 489 SDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASFFTPRSTRNDELL 544
+ S+ E L+S R ++L LA C L SS T N +
Sbjct: 1638 AQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ--TQNGNENQGEV 1695
Query: 545 SDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEEL 604
+ TF + L + PE + E S E A+++ +L L E+
Sbjct: 1696 EE---------QTFKEKE--------LDRKPEDVPPEILSNERYALQKANNRLLKILLEV 1738
Query: 605 KQKIKDINDQ--------MDESFRELDMECALLDGEQKSETTELMKE-------KEILDH 649
+ + + +D S + + E ++ + E + I +
Sbjct: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798
Query: 650 LNRKIAELEKNIVGEKTKEKVKL--------------DAEREKL------------ERLQ 683
+ + N+ + T+E +L D E E+L E+L
Sbjct: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLL 1858
Query: 684 ELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEE---- 739
E SE +QL++ + E +++ ++ + ES ++ ++L ESR E+
Sbjct: 1859 EAISETSSQLEHAKVTQTELMRESFRQKQEA--TESLKCQEELRERLHEESRAREQLAVE 1916
Query: 740 ---KENLTQQLLREVAEYQRNIVSRKEKISALKKQ---ANHIVQQAQREQDHFVKEKNNL 793
E + E ++R I + + I L+++ A++ +Q+ + EQ +E+
Sbjct: 1917 LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE-- 1974
Query: 794 IMMLQREKE 802
+L R+KE
Sbjct: 1975 --LLSRQKE 1981
Score = 40.8 bits (94), Expect = 0.008
Identities = 75/349 (21%), Positives = 140/349 (40%), Gaps = 45/349 (12%)
Query: 474 EDVQKINKE--LEKLQLSDEESV-FEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSA 530
E QKI + L QLS+E+ E ++ + R S D + L S
Sbjct: 3264 ESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3323
Query: 531 SFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS---QEL 587
+ + +++LL +L + S + +E+ + E+ R + L
Sbjct: 3324 TGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTL 3383
Query: 588 AAMEETRIVILNNLEELKQKIKDINDQMDESFRE---LDMECALLDG------EQKSETT 638
+E + EL+ K++D+ Q++E ++ LD+E L G +Q+ E
Sbjct: 3384 QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3443
Query: 639 ELMKEKEIL-DHLNRKIA-----------ELEKNIVGEKTKEK-----VKLDAE----RE 677
E + + IL +LN L++ I GE TKE ++++
Sbjct: 3444 EKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGE-TKESNYAKLIEMNGGGTGCNH 3502
Query: 678 KLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK------HFEDLEFQQLE 731
+LE +++ ++L P+ E+LQ + D D + V+ + L QQ E
Sbjct: 3503 ELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGE 3562
Query: 732 HESRLDEEKE--NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ 778
S + +LT++LLR+ AE +I E+ + L+ + +Q
Sbjct: 3563 EPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3611
Score = 40.0 bits (92), Expect = 0.014
Identities = 111/495 (22%), Positives = 198/495 (40%), Gaps = 87/495 (17%)
Query: 365 SHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS---SISG 421
S LL+ E + RN +EF +LE E K +S +
Sbjct: 2126 SELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQA 2185
Query: 422 RDDLMDYHRRQRE----ERLREQEMERLERQRLETI-LSLCAEYTKPDSRLSTGTTVEDV 476
D +D R+++E E EQ E LE + E L + E K +S T ++++
Sbjct: 2186 ERDAID--RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKEST----TRLQEL 2239
Query: 477 QKINK----ELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASF 532
++ NK ++EKL L+ +ES +A+ + D L A
Sbjct: 2240 EQENKLFKDDMEKLGLAIKES---DAMSTQDQHV------------------LFGKFAQI 2278
Query: 533 FTPRSTRNDELLSDLTRTPPPPSSTFPKASSE--SSYLSILPKTPEGISEEQ------RS 584
+ D+L +T+ T E + + L E + +Q R
Sbjct: 2279 IQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNRE 2338
Query: 585 QELAAMEETRIVILNNLEELKQKIK----DINDQMDESFRELDMECA-LLDGEQKSETT- 638
+E+ + E + L + QK ++++ D +LD+ A L EQ+ ET
Sbjct: 2339 EEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETAN 2398
Query: 639 -ELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCP 697
E+ K +L N K+ +L T+E L ERE +E++Q + +
Sbjct: 2399 EEMTFMKNVLKETNFKMNQL--------TQELFSLKRERESVEKIQSIPENSVNVAIDHL 2450
Query: 698 ESMREQLQQQLKRDADLLDVES----KHFED--------LEFQQLEHESRLDEEKENLTQ 745
+ +L+ L DA L +E+ K FE+ LE + L+ ES + + LTQ
Sbjct: 2451 SKDKPELEVVLTEDA-LKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2509
Query: 746 -----QLLREVAEYQRNIVSRK----EKISALKKQANHIVQQAQRE--QDHFVKEKNNLI 794
+ ++E +++ ++ +K +KI +K A +V Q Q E Q++ ++N
Sbjct: 2510 CYKQIKDMQEQGQFETEMLQKKIVNLQKI-VEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2568
Query: 795 MMLQREKENLCNLEK 809
+ + E+ N+ NL +
Sbjct: 2569 ISSEPERTNIQNLNQ 2583
Score = 39.3 bits (90), Expect = 0.024
Identities = 97/488 (19%), Positives = 190/488 (38%), Gaps = 69/488 (14%)
Query: 363 NPSH-----SLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS 417
+P+H S LAG+ + R V + L+ L++ + A+++R I+
Sbjct: 153 SPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEF----EAAIKQRDGIIT 208
Query: 418 SISGRDDLMDYHRRQREERLRE---------------QEMERLERQRLETILSLCAEYTK 462
++ + RR+++E +RE Q+++ E R T S A+ +
Sbjct: 209 QLTAN---LQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQ 265
Query: 463 PDSRLSTGTT--------VEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 514
++ T +ED QK KE +Q+S + + M D + K+ +
Sbjct: 266 AKQQILTHQQQLEEQDHLLEDYQK-KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 324
Query: 515 PDAD-----LASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLS 569
+ + L + + + T D+LL +L + E +
Sbjct: 325 QEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTN-- 382
Query: 570 ILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALL 629
K E S E+ Q + +EE + N ++ + + + E+ R+L+ A L
Sbjct: 383 --SKQKERQSSEEIKQLMGTVEELQ---KRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437
Query: 630 DGEQKSETTELMKEKEILDHL-------NRKIAELEK------NIVGEKTKEKVKLDAER 676
D E + MK++ I H+ R E+E NI + + K+ A
Sbjct: 438 D-EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN 496
Query: 677 EKLERLQELYSEQKTQLDNCPESMREQ--LQQQLKRDADLLDVESKHFEDLEFQQLEHES 734
E +LQ+ S+++ + + E+ LQ+QL+ + L + + E ES
Sbjct: 497 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQES 556
Query: 735 RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLI 794
+L+E ++L+ V + + IVS E L+ + V + + + KEKN ++
Sbjct: 557 KLNEAHKSLST-----VEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611
Query: 795 MMLQREKE 802
+ +E
Sbjct: 612 DRMAESQE 619
Score = 38.5 bits (88), Expect = 0.041
Identities = 100/540 (18%), Positives = 212/540 (39%), Gaps = 72/540 (13%)
Query: 603 ELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN-I 661
+ K++ K ++ ++ E +E+ + S+ ++ + K+ + ++ ++ +K I
Sbjct: 1509 KFKEEFKPLSKELGEHGKEILLS--------NSDPHDIPESKDCVLTISEEMFSKDKTFI 1560
Query: 662 VGEKTKEKVK---LDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV- 717
V + +++ +DA R+ + ++L E MR++L +Q + ++
Sbjct: 1561 VRQSIHDEISVSSMDASRQLMLNEEQL------------EDMRQELVRQYQEHQQATELL 1608
Query: 718 ESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ 777
H +E +Q E + +L EE + L +QL + + N+VS +E++ + +A +
Sbjct: 1609 RQAHMRQME-RQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLS 1667
Query: 778 QAQREQDHFVKEKNNLIMMLQREKENLCNLEK---KYSSLSGGKGFPVNPNTLKEGYISV 834
A RE+ E N Q EN +E+ K L K V P L ++
Sbjct: 1668 LAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELD-RKPEDVPPEILSNERYAL 1724
Query: 835 NEINE------------PCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSL 882
+ N + D + + A+ + S+ ++
Sbjct: 1725 QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVH 1784
Query: 883 EERKKQHKEGL--YLSDTLPR----------KKTTSSISPHFSSATMGRSITPK-AHLPL 929
EE + E + Y +PR ++ T S G I P+ L L
Sbjct: 1785 EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELML 1844
Query: 930 GQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSF 989
S+ + + L A+++ S + + M E RQK E A+ES
Sbjct: 1845 NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQE-----ATESLKCQEEL 1899
Query: 990 HYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEK 1049
H + +A + L+++ S + D + T +I+E ++ + E
Sbjct: 1900 RERLHE-ESRAREQLAVELSKAEGVI------DGYADEKTLFERQIQEKTDIIDRLEQE- 1951
Query: 1050 TRLLESREREMEAKKRALEEEKRRREILEKRLQEETS--QRQKLIEKEVKIRERQRAQAR 1107
+R +E+EA+++ ++EE+ ++ ++ E ++Q L E E ++E+ Q +
Sbjct: 1952 LLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011
Score = 33.1 bits (74), Expect = 1.7
Identities = 32/154 (20%), Positives = 74/154 (48%), Gaps = 22/154 (14%)
Query: 590 MEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDH 649
++E +V N+ L++ + + D + E+ +L ++L+ E ++E E K+ + +
Sbjct: 2707 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKL----SILEKEDETEVQE-SKKACMFEP 2761
Query: 650 LNRKIAELEKNIVGEKTKEKVKLDAEREKLERL-----------QELYSEQKTQLDNCPE 698
L K+++ + +T +K+ + + + L E SE+ T++ +
Sbjct: 2762 LPIKLSKS----IASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFT 2817
Query: 699 SMREQLQQQLKRDADLLDVESKHFEDLEFQQLEH 732
E++Q+ A++LD+ES+H + E + EH
Sbjct: 2818 EKIEKMQEL--HAAEILDMESRHISETETLKREH 2849
Score = 32.7 bits (73), Expect = 2.2
Identities = 80/406 (19%), Positives = 151/406 (37%), Gaps = 64/406 (15%)
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
E+ +E +LN + E K+ + ++ + + + L GE+ L KE+
Sbjct: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEEN-----LPKEET 1302
Query: 646 ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLE-RLQELYSEQKTQLDNCPESMREQL 704
++ ++ LE V K+K D E+ KLE ++QEL ES+ L
Sbjct: 1303 EFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL------------ESLISSL 1350
Query: 705 QQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEK 764
QQQLK + E + ++L+ S ++ ++ QR +
Sbjct: 1351 QQQLKETEQNYEAEIHCLQ----KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPG--- 1403
Query: 765 ISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE-----KENLCNL----------EK 809
S +KK + ++ + + VKE+ N++ +L+++ +E + + +
Sbjct: 1404 -SCVKKNIDGTIEFS---GEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQT 1459
Query: 810 KYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVL 869
+ S +SGG KE S + + C + + D T V
Sbjct: 1460 ELSRISGG----------KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDV- 1508
Query: 870 ASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR-----KKTTSSISPHFSSATMGRSITPK 924
+ KE F+ L + +H + + LS++ P K +IS S +
Sbjct: 1509 ----KFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQS 1564
Query: 925 AHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQ 970
H + S+ S +D + + HQQ +E RQ
Sbjct: 1565 IHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQ 1610
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 61.2 bits (147), Expect = 6e-09
Identities = 89/439 (20%), Positives = 182/439 (41%), Gaps = 65/439 (14%)
Query: 474 EDVQKINKEL--EKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSAS 531
ED ++IN EL +K +L DE S ++ + + K+ +++
Sbjct: 928 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEK----------HATENKVK 977
Query: 532 FFTPRSTRNDELLSDLTRTPPPPSSTFPKA----SSESSYLSILPKTPEGISEEQRSQEL 587
T + DE ++ LTR +A +E ++ L KT + ++ E
Sbjct: 978 NLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLES 1037
Query: 588 AAMEETRIVILNNLEELKQKIK--------------DINDQMDESFRELDMECALLDGEQ 633
+ +E ++ + +LE K+K++ + Q+DE ++ D E L +
Sbjct: 1038 SLEQEKKLRV--DLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKV 1095
Query: 634 KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQL 693
+ E T ++ ++ + L +I ELE+ I E+ + E+++ + +EL E +L
Sbjct: 1096 EDEQTLGLQFQKKIKELQARIEELEEEIEAERA---TRAKTEKQRSDYAREL-EELSERL 1151
Query: 694 DNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAE 753
+ Q++ KR+A+ L + DLE L+HE+ + ++ +
Sbjct: 1152 EEAGGVTSTQIELNKKREAEFLKLR----RDLEEATLQHEAMVAALRK-----------K 1196
Query: 754 YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSS 813
+ ++ E+I L++ + Q+ ++E+ F E ++L ++ ++ NLEK +
Sbjct: 1197 HADSVAELGEQIDNLQR----VKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRT 1252
Query: 814 LSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQP 873
L + L E EI T Q A + E ++++
Sbjct: 1253 LE---------DQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLS 1303
Query: 874 QSKEHF-RSLEERKKQHKE 891
+SK+ F + EE K+Q +E
Sbjct: 1304 RSKQAFTQQTEELKRQLEE 1322
Score = 52.0 bits (123), Expect = 4e-06
Identities = 87/408 (21%), Positives = 182/408 (44%), Gaps = 52/408 (12%)
Query: 433 REERLREQEMERLERQRLETILSLCAEY-TKPDSRLSTGTTVEDVQKINKEL-EKLQLSD 490
RE+ EQE + ++ L S A++ TK ++ T E++++ K+L ++LQ S+
Sbjct: 1345 REQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT--EELEEAKKKLAQRLQDSE 1402
Query: 491 E--ESVFEEALMSPDTRYRCHRK--DSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD 546
E E+V + T+ R + D + D + A+ S A+ + D++L++
Sbjct: 1403 EQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERAN------SLAAALDKKQRNFDKVLAE 1456
Query: 547 LTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQ 606
+ + ES LS + EE A+++ V N + L+Q
Sbjct: 1457 WKTKCEESQAELEASLKESRSLSTELFKLKNAYEE-------ALDQLETVKREN-KNLEQ 1508
Query: 607 KIKDINDQMDES---FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVG 663
+I D+ +Q+ E+ EL+ ++ E+ L + + L+H KI ++ +
Sbjct: 1509 EIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQ 1568
Query: 664 EKTKEKVKLDAEREKLERLQELYSE----QKTQLDNCPESMREQLQQQLKRDADLLDVE- 718
K++ K+ + E++E+L+ Y ++ LD S E ++ + K + DL ++E
Sbjct: 1569 VKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEI 1628
Query: 719 ------------SKHFEDLEFQQLEHESRLDEE---KENLTQQLLREVAEYQRNIVSRK- 762
KH ++ Q + + LD+ +E+L +QL + E + N++ +
Sbjct: 1629 QLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQL--AIVERRANLLQAEV 1686
Query: 763 EKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810
E++ A +Q + A++E + + N + +L + +L + +KK
Sbjct: 1687 EELRATLEQTERARKLAEQE----LLDSNERVQLLHTQNTSLIHTKKK 1730
Score = 48.9 bits (115), Expect = 3e-05
Identities = 104/536 (19%), Positives = 211/536 (39%), Gaps = 73/536 (13%)
Query: 568 LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECA 627
L + ++ + E+R +L + + + E + ++IN ++ R+L+ EC+
Sbjct: 890 LQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECS 949
Query: 628 LLDGE-QKSETTELMKEKE------ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLE 680
L + E T EKE + +L +++ L++ I ++K +A ++ L+
Sbjct: 950 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALD 1009
Query: 681 RLQ------ELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHES 734
LQ ++ K++L+ E + L+Q+ K DL + K DL+ Q E
Sbjct: 1010 DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQ-ESIL 1068
Query: 735 RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLI 794
L+ +K+ L ++L ++ EY + + S+ E L Q +++ Q + +E
Sbjct: 1069 DLENDKQQLDERLKKKDFEYCQ-LQSKVEDEQTLGLQFQKKIKELQARIEELEEE----- 1122
Query: 795 MMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFP 854
++ E+ EK+ S + L+E ++E E G T+
Sbjct: 1123 --IEAERATRAKTEKQRSDYA---------RELEE----LSERLEEAGGVTSTQIELNKK 1167
Query: 855 ADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSS 914
+A+ + R LEE QH+ + RKK S++
Sbjct: 1168 REAEFLKLR----------------RDLEEATLQHEAMV----AALRKKHADSVAELGEQ 1207
Query: 915 ATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEF 974
+ + K + L S+ +++K + + Q+SE R K+E
Sbjct: 1208 IDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEA-RGKNEE 1266
Query: 975 YNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIAR 1034
R+ SE + T + + S +E S S +S + + +
Sbjct: 1267 IQRSLSELTT------------QKSRLQTEAGELSRQLEEKESIVS--QLSRSKQAFTQQ 1312
Query: 1035 IEEMERLLKQAHAEKTRL---LESREREMEAKKRALEEEKRRREILEKRLQEETSQ 1087
EE++R L++ + K L L+S + + + EEE+ + L++ L + S+
Sbjct: 1313 TEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE 1368
Score = 47.4 bits (111), Expect = 9e-05
Identities = 101/477 (21%), Positives = 184/477 (38%), Gaps = 69/477 (14%)
Query: 396 ESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLE--RQRLETI 453
E ++ Q AL + S ++ + + R + E +++ +RL+ +++E +
Sbjct: 1349 EEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAV 1408
Query: 454 LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQ--LSDEESVFEEALMSPDTRYRCHRK 511
+ CA K RL VED+ + L L ++ F++ L T+ C
Sbjct: 1409 NAKCASLEKTKQRLQG--EVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTK--CEES 1464
Query: 512 DSLPDADLASCGSLSQSSASFFTPRSTRNDEL-------------LSDLTRTPPPPSSTF 558
+ +A L SLS D+L ++DLT T
Sbjct: 1465 QAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTI 1524
Query: 559 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 618
+ + + + EE AA+E IL EL Q +I+ ++ E
Sbjct: 1525 HELEKSRKQIELEKADIQLALEEAE----AALEHEEAKILRIQLELTQVKSEIDRKIAEK 1580
Query: 619 FRELD------------MECALLDGEQKSETTELMKEKEI----------LDHLNRKIAE 656
E++ M+ AL D E +S + +K++ L H NR+ AE
Sbjct: 1581 DEEIEQLKRNYQRTVETMQSAL-DAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAE 1639
Query: 657 LEKN---IVGEKTKEKVKLDAEREKLERLQE---LYSEQKTQLDNCPESMREQLQQQLKR 710
K+ + G+ ++ LD E L+E + + L E +R L+Q +
Sbjct: 1640 TLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERA 1699
Query: 711 ----DADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQ--QLLREVAEYQRNIVSRKEK 764
+ +LLD E ++ ++ S + +K+ T QL EV + R+ + +EK
Sbjct: 1700 RKLAEQELLDSN----ERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEK 1755
Query: 765 ISALKKQANHIVQQAQREQD---HFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGK 818
A + ++ ++EQD H + K NL ++ + L E+ +L GGK
Sbjct: 1756 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ--LALKGGK 1810
Score = 41.6 bits (96), Expect = 0.005
Identities = 39/184 (21%), Positives = 82/184 (44%), Gaps = 23/184 (12%)
Query: 584 SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKE 643
++EL ++T + + L+Q +KD+ ++DE+ E L
Sbjct: 1767 AEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA-----------------EQLALKGG 1809
Query: 644 KEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNC--PESMR 701
K+ + L +I ELE + GE+ K + R+ R++EL + + N + +
Sbjct: 1810 KKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLV 1869
Query: 702 EQLQ---QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI 758
++LQ + KR A+ D E + +F++ +HE EE+ ++ + + ++ R+
Sbjct: 1870 DKLQVKVKSYKRQAEEAD-EQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDF 1928
Query: 759 VSRK 762
S +
Sbjct: 1929 TSSR 1932
Score = 35.8 bits (81), Expect = 0.26
Identities = 80/377 (21%), Positives = 140/377 (37%), Gaps = 58/377 (15%)
Query: 748 LREVAEYQRNIVSRKEKISALKKQ-ANHIVQQAQREQD--HFVKEKNNLIMMLQREKENL 804
L + AE ++ + + KE+ K + A ++ + E+ V+EKN+L + +Q E ENL
Sbjct: 840 LLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENL 899
Query: 805 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEP 864
+ E++ L K F + + E+ E + ++ A E
Sbjct: 900 LDAEERCDQLIKAK-FQLE--------AKIKEVTERAEDEEEINAE----LTAKKRKLED 946
Query: 865 ATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPK 924
+ L E + E++K E + T + S + + T + +
Sbjct: 947 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLT----EELSGLDETIAKLTREKKALQE 1002
Query: 925 AHL-----------PLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSE 973
AH + N S L + + E + LR E +++K E
Sbjct: 1003 AHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLR-----VDLERNKRKLE 1057
Query: 974 FYNRTASESNVYL-NSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNI 1032
+ A ES + L N D K + F+ L S E ++ I
Sbjct: 1058 GDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQ---- 1113
Query: 1033 ARIEEMERLLKQAHAEKTRLLESRE---REMEAKKRALEE------------EKRRREIL 1077
ARIEE+E ++ A + + + R RE+E LEE +KR E L
Sbjct: 1114 ARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFL 1173
Query: 1078 EKR--LQEETSQRQKLI 1092
+ R L+E T Q + ++
Sbjct: 1174 KLRRDLEEATLQHEAMV 1190
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 61.2 bits (147), Expect = 6e-09
Identities = 151/727 (20%), Positives = 289/727 (39%), Gaps = 91/727 (12%)
Query: 137 ERALRLSE-KPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISR 195
E+A+R+ + + S+Y R HD + +E K +L + + L D +R
Sbjct: 317 EKAVRVDKLESEVSRYKER--LHDIEFYKARVEELKEDNQVL-LETKTMLEDQLEGTRAR 373
Query: 196 SGAASMPSSPKQARKMSIQDSLALQPKLTRHK--ELASENINLR-TRKYSSSSLSHMGAY 252
S K + D + ++ + R K EL EN+ L +K S H+G
Sbjct: 374 SDKLHELEKENLQLKAKLHD-MEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGW- 431
Query: 253 SRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGAL 312
L ++ R +E LS P+ SLG+ + L + + L +
Sbjct: 432 --ELEQISRTSE-----LSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
Query: 313 PYKTSASE------GNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV------ 360
+ +AS+ N +S + + + V K L + + + D + + +
Sbjct: 485 SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
Query: 361 ---GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS 417
+ +L E++ + T + S EA ++ + + + +++E S +S
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
Query: 418 SISG-----RDDLMDYHRRQREERLREQEMERLER-----QRLETILSLCAEYTKPDSRL 467
I + +L Y + E E+ LE+ Q+ T L + E + +
Sbjct: 605 KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664
Query: 468 STGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYRCHRKDSLPDADLASCGSLS 526
++ ++++ N++L+K S + F+ E+L +++ + + + C S+
Sbjct: 665 NS-----ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK 719
Query: 527 QSSASFFTPRSTRNDELLSD---LTRTPPPPSSTFPKASS-ESSYLSI------LPKTPE 576
+ N EL S+ L + ++F K E SY + L KT E
Sbjct: 720 MAQLQL------ENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE 773
Query: 577 GISE--EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQK 634
++ +Q EL +E + NLEELK K + +Q+++ + L+ E + L+ ++K
Sbjct: 774 NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL-EQLEKENKSLEQETSQLEKDKK 832
Query: 635 S---ETTELMKEKEI----LDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYS 687
E L ++ EI L+ N KI LEK KT K ++ +E RL+EL
Sbjct: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE---NKTLSK-EIGIYKESCVRLKELEK 888
Query: 688 EQKTQLDNCP------ESMREQL------QQQLKRDADLLDVESKHFEDLEFQQLEHESR 735
E K + ++RE L QQ+ D + L E + + + L E
Sbjct: 889 ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS 948
Query: 736 LDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIM 795
D+ + L + L + +++ ++EKI+AL+ + Q+ + K N
Sbjct: 949 TDDSRYKLLESKLESTLK--KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1006
Query: 796 MLQREKE 802
+ QR+ E
Sbjct: 1007 LKQRQDE 1013
Score = 53.5 bits (127), Expect = 1e-06
Identities = 92/453 (20%), Positives = 176/453 (38%), Gaps = 54/453 (11%)
Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREER--LREQEMERLERQR 449
+A + LRQ L + K + + ++ R Q+E L + R+ R
Sbjct: 257 KAKIRRLRQELEEKTEQLLDCKQELEQME-----IELKRLQQENMNLLSDARSARMYRDE 311
Query: 450 LETILSLCAEYTKPDSRLST-GTTVEDVQKINKELEKLQLSDEESVFEEALMSPD----T 504
L+ + K +S +S + D++ +E+L+ D + + E M D T
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK-EDNQVLLETKTMLEDQLEGT 370
Query: 505 RYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKAS-- 562
R R + L +L L R + + ++T S
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430
Query: 563 ------SESSYLSILPKTPEGIS-EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQM 615
S +S LS P+ G E S L +E + +EEL+ + +
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA 490
Query: 616 DESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAE 675
+ + ++ E L + + E+++EK+ L + L K+++ EK + + ++
Sbjct: 491 SKILK-MEKENQRLSKKVEILENEIVQEKQSLQNCQN----LSKDLMKEKAQLEKTIETL 545
Query: 676 REKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVE-------------SKHF 722
RE ER ++ ++ L+ S+R+ + Q+ +A + D+E S
Sbjct: 546 RENSERQIKILEQENEHLNQTVSSLRQ--RSQISAEARVKDIEKENKILHESIKETSSKL 603
Query: 723 EDLEFQ------QLEH---ESRLDEEKENLTQQLLREVAEYQRNIVSRK---EKISALKK 770
+EF+ +LEH + EE EN L +E Q+ I + K EKI AL++
Sbjct: 604 SKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663
Query: 771 QANHIVQQAQREQDHFVKEKNNLIMMLQREKEN 803
+ + + ++ ++ + KN + EKEN
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKEN 696
Score = 47.8 bits (112), Expect = 7e-05
Identities = 116/567 (20%), Positives = 226/567 (39%), Gaps = 56/567 (9%)
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQM-DESFRELDMECALLDGEQKSETTELMKEK 644
EL A+ E + +++L+ ++ +++ D F + +E D + ET +++++
Sbjct: 311 ELDALREKAV----RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 366
Query: 645 -EILDHLNRKIAELEKNIVGEKTK---EKVKLDAEREKLERLQELYSEQKTQLDNCPESM 700
E + K+ ELEK + K K +++ D +R+K+E L E E T +SM
Sbjct: 367 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME---ENMTLEMAQKQSM 423
Query: 701 REQLQ-----QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQ 755
E L +Q+ R ++L + K E +L L E EN Q L + V E +
Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGH-EVNELTSSRLLKLEMEN--QSLTKTVEELR 480
Query: 756 RNIVS---RKEKISALKKQANHIVQQAQREQDHFVKEKN------NLIMMLQREKENLCN 806
+ S KI ++K+ + ++ + ++ V+EK NL L +EK
Sbjct: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK---AQ 537
Query: 807 LEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPAT 866
LEK +L N+ ++ I E ++L +Q A+A E
Sbjct: 538 LEKTIETL--------RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589
Query: 867 AVL-ASQPQSKEHFRSLEERKKQHKEGL-YLSDTLPRKKTTSSISPHFSSAT--MGRSIT 922
+L S ++ +E K+Q K+ L + + R + + H + + IT
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKIT 649
Query: 923 PKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASES 982
+C + + E+R++ + + + + E N E
Sbjct: 650 -------NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE 702
Query: 983 NVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLL 1042
N+ L + L L++ + + AS R+E + L
Sbjct: 703 NLELRR-NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL 761
Query: 1043 KQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQE--ETSQRQKLIEKEVKIRE 1100
+ + LE+ ++++ + L++ + + L+K L+E +S+R + +EKE K E
Sbjct: 762 DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLE 821
Query: 1101 RQRAQARPLTRYLPVRKEDFDLRSHVE 1127
++ +Q + L KE+ LR E
Sbjct: 822 QETSQLEKDKKQL--EKENKRLRQQAE 846
Score = 47.0 bits (110), Expect = 1e-04
Identities = 86/418 (20%), Positives = 180/418 (43%), Gaps = 80/418 (19%)
Query: 432 QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINK---------- 481
+R+ ++ EQE E L +T+ SL + S++S V+D++K NK
Sbjct: 550 ERQIKILEQENEHLN----QTVSSL-----RQRSQISAEARVKDIEKENKILHESIKETS 600
Query: 482 ------ELEKLQLSDEESVFEE----ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSAS 531
E EK Q+ E ++E A + + +++ L + + + +
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
Query: 532 FFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQ-------RS 584
++ S+L R T + + L L K + EE S
Sbjct: 661 L--------EQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712
Query: 585 QELAAMEETRIVILNN-LEELKQKIKD----------INDQMDESFRELDMECALLDGEQ 633
+ A+M+ ++ + N LE K+++K ++++ S++ LD+E L
Sbjct: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772
Query: 634 KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAER-EKLERLQELYSEQKTQ 692
++ ++ + + L L + L+KN+ E++K+ ++R E+LE+ + ++ +Q
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNL------EELKISSKRLEQLEKENKSLEQETSQ 826
Query: 693 LDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDE-EKENLTQQLLREV 751
L E ++QL+++ KR +++ E E+ ++ EKEN T L +E+
Sbjct: 827 L----EKDKKQLEKENKRLRQQAEIKDTTLE-------ENNVKIGNLEKENKT--LSKEI 873
Query: 752 AEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEK 809
Y+ + V KE L+K+ +V++A + V + +L+ + ++ +LEK
Sbjct: 874 GIYKESCVRLKE----LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927
Score = 45.4 bits (106), Expect = 3e-04
Identities = 97/472 (20%), Positives = 195/472 (41%), Gaps = 49/472 (10%)
Query: 372 ESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRR 431
E+ R+ T N S ++ E++L+ L + T Q L E K S + +
Sbjct: 764 ENQRLQKTLEN-SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE---------QL 813
Query: 432 QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKI-NKELEKLQLSD 490
++E + EQE +LE+ + + L + + + + T E+ KI N E E LS
Sbjct: 814 EKENKSLEQETSQLEKDKKQ--LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
Query: 491 EESVFEEALMSPDTRYRCHRKDSLPDA--DLASCGSLSQSSASFFTPRSTRNDELLSDLT 548
E +++E+ + + K+ + A D+ + +L + S N++L LT
Sbjct: 872 EIGIYKESCVRLKELEK-ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL-EKLT 929
Query: 549 RTPPPPSST-----FPKASSESSYLSILPKTPEGI---SEEQRSQELAAMEETRIVILNN 600
+ S++ S +L E S E + +++AA+E N
Sbjct: 930 HELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY 989
Query: 601 LEELKQKIKDIN------------DQMDESFRELDMECALLDGEQKSETTELMKEKEILD 648
++L+Q++K + ++M +S + E + E + T EL+K K+ L
Sbjct: 990 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1049
Query: 649 HLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQL 708
+ R A L+ KT+ K +L+ + L+ Q L +++ Q +L
Sbjct: 1050 EVERNNATLQAEKQALKTQLK-QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ-NAKL 1107
Query: 709 KRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISAL 768
+ + L+ +S + Q L +S L+ E E++ ++ ++ +++ EK+ L
Sbjct: 1108 QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE-REDLKSLYDSLIKDHEKLELL 1166
Query: 769 -KKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKG 819
++QA+ E + + + L + + +LE +Y+ L KG
Sbjct: 1167 HERQAS--------EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKG 1210
Score = 40.0 bits (92), Expect = 0.014
Identities = 44/193 (22%), Positives = 94/193 (48%), Gaps = 17/193 (8%)
Query: 585 QELAAMEETRIVILN-NLEELKQKIKDI---NDQMDESFRELDMECALLDGEQKSETTEL 640
+++ +E+ ++++ N N E + + K + ND+++ ++ +L E +L + K+
Sbjct: 1216 EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNL---- 1271
Query: 641 MKEKEILDHLNRKIAELEKNIVGEKTKEKVK-LDAEREKLERLQELYSEQKTQLDNCPES 699
K +L+ N K+ + K KE+ + LD KL EL S+ K L+
Sbjct: 1272 ---KSLLN--NSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1326
Query: 700 MREQLQQQLKRDADLLD--VESKHFEDLEFQQ-LEHESRLDEEKENLTQQLLREVAEYQR 756
+ +Q+Q + ++ LL+ +ESK +E +Q ++ + L +KE L ++++ + Y
Sbjct: 1327 LLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDP 1386
Query: 757 NIVSRKEKISALK 769
+ R+ LK
Sbjct: 1387 SPPRRRGNWITLK 1399
Score = 31.2 bits (69), Expect = 6.5
Identities = 43/224 (19%), Positives = 103/224 (45%), Gaps = 30/224 (13%)
Query: 605 KQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGE 664
++ +K + D + + +L+ LL Q SE L+ + L ++ + E+E + +
Sbjct: 1146 REDLKSLYDSLIKDHEKLE----LLHERQASEYESLISKHGTLKSAHKNL-EVEHRDLED 1200
Query: 665 KTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFED 724
+ + +K + E LE++ ++ E+ + E++ + ++ + L S+ ++
Sbjct: 1201 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1260
Query: 725 LEFQQLEHE--------SRLDEEKENLTQQLLREVAEYQR-NIVSRK-----EKISALK- 769
E Q +H+ S+L++ + L+E +YQ+ +I S K E +S LK
Sbjct: 1261 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE--QYQQLDITSTKLNNQCELLSQLKG 1318
Query: 770 ---KQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810
++ H++ Q Q + +N ++ E ++L ++E++
Sbjct: 1319 NLEEENRHLLDQIQT-----LMLQNRTLLEQNMESKDLFHVEQR 1357
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 61.2 bits (147), Expect = 6e-09
Identities = 110/502 (21%), Positives = 204/502 (40%), Gaps = 81/502 (16%)
Query: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
G D L+ ++ +E R++E E +E I C E K S+ S ++++
Sbjct: 990 GNDYLVS--KQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKS-----HQIEELE 1042
Query: 481 KELEKLQ------------LSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528
+++EKLQ L ++E ++ L+ K+ L + ++ +
Sbjct: 1043 QQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHV 1102
Query: 529 SASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELA 588
LS+LT+ T KA + + + E + Q++
Sbjct: 1103 ---------VEGKRALSELTQ-----GVTCYKAKIKELETILETQKVECSHSAKLEQDIL 1148
Query: 589 AMEETRIVILNNLEELKQKIKD-INDQMDESFRELDMECALLDGEQKSETTELMKEKEIL 647
E + + NL+E ++ ++D + + D + +EL + K E T+L + +
Sbjct: 1149 EKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKL---------KEEITQLTNNLQDM 1199
Query: 648 DHLNRKIAELEKNIVGEKTKEKVKLDAE-------REKLERLQELYSEQKTQLDNCPESM 700
HL + E E+ E K K +L A + L+R +E Y++ K +L + + +
Sbjct: 1200 KHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQI 1259
Query: 701 RE-QLQQQLKRDAD-LLDVESKHFEDLE---FQQLEHESR-LDEEKENLTQQLLRE-VAE 753
++ Q + + RD D LL ++ E + Q+L+ + R + + KE L Q + E + +
Sbjct: 1260 KQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQ 1319
Query: 754 YQR--NIVSRKEKISALKKQANHIVQQAQREQDHFVKEK----NNLIMMLQREKENLCNL 807
Y+R ++ KEKI + +Q Q EQD ++ K L L++ KE +L
Sbjct: 1320 YERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDL 1379
Query: 808 EKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPA---DADAVATEP 864
E K + S K N + L G TNL Q +AD
Sbjct: 1380 ETKNNQRS-NKEHENNTDVL--------------GKLTNLQDELQESEQKYNADRKKWLE 1424
Query: 865 ATAVLASQPQSKEHFRSLEERK 886
+L +Q + E+ R+ E +K
Sbjct: 1425 EKMMLITQAKEAENIRNKEMKK 1446
Score = 37.4 bits (85), Expect = 0.091
Identities = 62/306 (20%), Positives = 125/306 (40%), Gaps = 49/306 (16%)
Query: 559 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN------LEELKQKIKDIN 612
P A S ++S + SEE R +A +E+ R++ NN L ++ ++K+
Sbjct: 804 PPAKKGSIHVSSAITEDQKKSEEVRPN-IAEIEDIRVLQENNEGLRAFLLTIENELKNEK 862
Query: 613 DQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAEL--EKNIVGEKTKEKV 670
++ E +++ L +K T + ++I + + IAEL +K+ E+ ++ +
Sbjct: 863 EEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIM 922
Query: 671 KLDAERE------------------KLERLQELYSEQKTQLDNCPESMREQLQQQLKRD- 711
KL E E K++ L+ L + +Q+ N L + D
Sbjct: 923 KLSNEIETATRSITNNVSQIKLMHTKIDELRTL--DSVSQISNIDLLNLRDLSNGSEEDN 980
Query: 712 -----ADLLDVE---SKHFEDLEFQQLEHESRLDEEKENLTQQLLR----------EVAE 753
DLL + SK ++ Q+ E+ E + ++ ++ E
Sbjct: 981 LPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEE 1040
Query: 754 YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE-KENLCNLEKKYS 812
++ I + ++ K + N + ++ + QD +KEK LI L+ E +E L+ +
Sbjct: 1041 LEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQ 1100
Query: 813 SLSGGK 818
+ GK
Sbjct: 1101 HVVEGK 1106
Score = 32.0 bits (71), Expect = 3.8
Identities = 21/88 (23%), Positives = 45/88 (51%), Gaps = 5/88 (5%)
Query: 1035 IEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--REILEKRLQEETSQRQKLI 1092
+EE+E + + E L E ++ +E K + E++R +++E ++ +++++ +
Sbjct: 536 VEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKL 595
Query: 1093 EKEVKIRERQRAQARPLTRYLPVRKEDF 1120
E KIRE + T+Y R+ DF
Sbjct: 596 TLEFKIREE---VTQEFTQYWAQREADF 620
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 60.5 bits (145), Expect = 1e-08
Identities = 101/452 (22%), Positives = 195/452 (43%), Gaps = 58/452 (12%)
Query: 392 EADLESLRQASGTPQPALRERKSSISSISGR-DDLMDYHRRQREE-RLREQEMERLERQR 449
E +LE+ R A + E + +S R ++ QRE R RE E+ RL R+
Sbjct: 1168 EEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRREL 1227
Query: 450 LETILSLCAEYT-----KPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDT 504
E L A + + G V+ +Q++ ++LEK E+S E M D
Sbjct: 1228 EEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEK-----EKS---ELRMEVD- 1278
Query: 505 RYRCHRKDSLPDADLAS-CGSLSQSSASFFTPRSTRNDEL------LSDLTRTPPPPSST 557
DLA+ +L+++ AS T D+L + +L R S+
Sbjct: 1279 -------------DLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQ 1325
Query: 558 FPKASSESSYLSILPKTPEG-ISEEQRSQELAAMEETRIVILNNLEELKQKIKD---IND 613
+ +ES LS L + E IS+ R + LAA +LEEL++++++
Sbjct: 1326 RGRLQTESGELSRLLEEKECLISQLSRGKALAAQ---------SLEELRRQLEEESKAKS 1376
Query: 614 QMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLD 673
+ + + L +C LL + + E + + +L N ++A+ + + +L+
Sbjct: 1377 ALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELE 1436
Query: 674 AEREKLE-RLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEF---QQ 729
++KL RLQE +E+ + N S E+ + +L+ +++ + +E + ++
Sbjct: 1437 EAKKKLALRLQE--AEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKK 1494
Query: 730 LEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALK---KQANHIVQQAQREQDHF 786
H R EE+ +++ RE+ QR ++ L+ ++A ++ +RE +
Sbjct: 1495 QRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNL 1554
Query: 787 VKEKNNLIMMLQREKENLCNLEKKYSSLSGGK 818
+E ++L + +++ LEK +L G K
Sbjct: 1555 QEEISDLTDQVSLSGKSIQELEKTKKALEGEK 1586
Score = 47.4 bits (111), Expect = 9e-05
Identities = 164/785 (20%), Positives = 278/785 (35%), Gaps = 166/785 (21%)
Query: 396 ESLRQASGTPQPALRERKSSISSISGR--DDLMDYHRRQREERLREQEMERLERQRLETI 453
E+ +QA G Q A +R S+++ R + D +E+ + ER +R +LE
Sbjct: 1050 EAHQQALGDLQ-AEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKR-KLEGD 1107
Query: 454 LSLCAEYT---------------KPDSRLST-GTTVEDVQ----KINKELEKLQLSDEES 493
L L E K DS LS VED Q ++ K++++LQ EE
Sbjct: 1108 LKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEEL 1167
Query: 494 VFE-EALMSPDTRYRCHRKDSLPDAD-----LASCGSLSQSSASFFTPRSTRNDELLSDL 547
E EA + R R ++ + + L G S R L +L
Sbjct: 1168 EEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRREL 1227
Query: 548 TRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQK 607
E++ ++ K EG +E +++ +++ R + EL+ +
Sbjct: 1228 EEAA---------LRHEATVAALRRKQAEGAAE--LGEQVDSLQRVRQKLEKEKSELRME 1276
Query: 608 IKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTK 667
+ D+ ++ R A E+ T E + L K+ EL++ + T
Sbjct: 1277 VDDLAANVETLTR------AKASAEKLCRTYE-----DQLSEAKIKVEELQRQLADAST- 1324
Query: 668 EKVKLDAEREKLERLQE-------LYSEQKTQLDNCPESMREQLQQQLKRDADLLDVES- 719
++ +L E +L RL E S K E +R QL+++ K + L
Sbjct: 1325 QRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQA 1384
Query: 720 -KHFEDLEFQQLEHESRLDEEKENLTQQLLREVAE----YQRNIVSRKEKISALKKQANH 774
+H DL +Q E E+ E + L + EVA+ Y+ + + R E++ KK+
Sbjct: 1385 LRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKK--- 1441
Query: 775 IVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISV 834
L + LQ +E + K SSL K + T E
Sbjct: 1442 ------------------LALRLQEAEEGVEAANAKCSSLEKAK---LRLQTESEDV--- 1477
Query: 835 NEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQ------ 888
+ L +T A D A+ + Q +E R LE +++
Sbjct: 1478 ---------TLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGT 1528
Query: 889 --------HKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPL--------GQS 932
H+E L +TL K+ ++ S T S++ K+ L G+
Sbjct: 1529 ELFRLRHGHEEALEALETL--KRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEK 1586
Query: 933 NSCGSVLPPSLAAM--------------------------AKDSESRRMLRGYNHQQMSE 966
+ + L + A+ KD E + R NHQ+ E
Sbjct: 1587 SEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRR--NHQRAVE 1644
Query: 967 GHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISS 1026
+ + R +E + D L L + T A + +
Sbjct: 1645 SLQASLDAETRARNE------ALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQ 1698
Query: 1027 ASTSNIARIEEMERLLKQAHAEKTRLLESR----EREMEAKKRALEEEKRRREILEKRLQ 1082
R EE +RL + H E+ + LE R E+E + ALE+ +R R + E+ L
Sbjct: 1699 LKEEQAGRDEE-QRLAAELH-EQAQALERRASLLAAELEELRAALEQGERSRRLAEQELL 1756
Query: 1083 EETSQ 1087
E T +
Sbjct: 1757 EATER 1761
Score = 42.4 bits (98), Expect = 0.003
Identities = 105/467 (22%), Positives = 174/467 (37%), Gaps = 71/467 (15%)
Query: 398 LRQASGTPQPALRERKSSISSISGRDDL----MDYHRRQREER----------------- 436
L+ SG L E++ IS +S L ++ RRQ EE
Sbjct: 1329 LQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHD 1388
Query: 437 ---LREQEMERLERQ-RLETILSLC-AEYTKPDSRLSTGTT--VEDVQKINKELEKLQLS 489
LREQ E E Q L+ +LS AE + S+ E++++ K+L L+L
Sbjct: 1389 CDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLA-LRLQ 1447
Query: 490 DEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTR 549
+ E E A + + + D+ + S+A+ + + L + R
Sbjct: 1448 EAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRR 1507
Query: 550 TPPPPSSTFPKASSESSYLSI-LPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKI 608
A ES L L + G E + E E NL+E +
Sbjct: 1508 QEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKREN------KNLQEEISDL 1561
Query: 609 KDINDQMDESFRELDMECALLDGEQKSETTELMKEKE-ILDHLNRKIAELEKNIVGEKTK 667
D +S +EL+ L+GE KSE ++E E L+ K ++ + K +
Sbjct: 1562 TDQVSLSGKSIQELEKTKKALEGE-KSEIQAALEEAEGALELEETKTLRIQLELSQVKAE 1620
Query: 668 EKVKLDAEREKLERL----QELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFE 723
KL + E+ L Q + LD + E L+ + K + DL D+E
Sbjct: 1621 VDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLE----- 1675
Query: 724 DLEFQQLEHESRLDEEKENLTQ----QLLREVA---EYQRNIVSRKEKISALKKQANHIV 776
QL H +R E + T+ QL E A E QR E+ AL+++A+ +
Sbjct: 1676 ----LQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLA 1731
Query: 777 -------------QQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810
++++R + + E + +L + L N +KK
Sbjct: 1732 AELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKK 1778
Score = 40.8 bits (94), Expect = 0.008
Identities = 38/172 (22%), Positives = 79/172 (45%), Gaps = 14/172 (8%)
Query: 652 RKIAELEKNIVGEKTKEKVKLDAEREKLERLQE---LYSEQKTQLDNCPESMREQLQQQL 708
+++ E +I EK ++L AE++ L +E L + K QL+ + + E+L+ +
Sbjct: 920 QELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEE 979
Query: 709 KRDADL------LDVE----SKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI 758
+ +ADL L+ E K +DL+ + E + EN + L E+A ++
Sbjct: 980 EVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKE-KQATENKVKNLTEEMAALDESV 1038
Query: 759 VSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810
++ AL++ + Q E+D + + Q+ ++ C+LE++
Sbjct: 1039 ARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQE 1090
Score = 39.3 bits (90), Expect = 0.024
Identities = 76/363 (20%), Positives = 141/363 (38%), Gaps = 45/363 (12%)
Query: 372 ESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRR 431
E D A R +VE +A L++ +A ALR +K ++ + + + R
Sbjct: 1627 EKDEECANLRRNHQRAVESLQASLDAETRARNE---ALRLKKKMEGDLNDLELQLGHATR 1683
Query: 432 QREE----------RLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINK 481
Q E +L+E++ R E QRL L A+ + + L +E+++ +
Sbjct: 1684 QATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASL-LAAELEELRAALE 1742
Query: 482 ELEKLQLSDEESVFEEA----LMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRS 537
+ E+ + E+ + E L+ ++K L +ADLA + +A
Sbjct: 1743 QGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKL-EADLAQLSGEVEEAAQERREAE 1801
Query: 538 TRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVI 597
+ + ++D + K S++L + KT E E + A +EE
Sbjct: 1802 EKAKKAITDAAMM----AEELKKEQDTSAHLERMKKTLEQTVRELQ----ARLEEAEQAA 1853
Query: 598 LNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAEL 657
L ++ QK+ + REL+ E LD EQK L K + H R
Sbjct: 1854 LRGGKKQVQKL-------EAKVRELEAE---LDAEQKKHAEAL---KGVRKHERRV---- 1896
Query: 658 EKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDV 717
K + + +++ L ++ +++LQ K Q + + L + K +L D
Sbjct: 1897 -KELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDA 1955
Query: 718 ESK 720
E +
Sbjct: 1956 EER 1958
Score = 33.1 bits (74), Expect = 1.7
Identities = 25/105 (23%), Positives = 57/105 (54%), Gaps = 8/105 (7%)
Query: 1026 SASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRA---LEEEKRRREI---LEK 1079
+A ++AR+ + ++ L++AH + L++ E + A +A LE++ E EK
Sbjct: 1032 AALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEK 1091
Query: 1080 RLQEETSQRQKLIEKEVKIRERQRAQARPLTRYL--PVRKEDFDL 1122
+L+ +T + ++ +E ++K+ + A A + L ++K+D +L
Sbjct: 1092 KLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSEL 1136
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 60.1 bits (144), Expect = 1e-08
Identities = 73/393 (18%), Positives = 167/393 (42%), Gaps = 26/393 (6%)
Query: 431 RQREERLREQEMERLERQRLETILSLCAEYTKPD---SRLSTGTTVEDVQKINKELEKLQ 487
++ EE++ E E E++ + L A K + SR T T E+++ + E ++L
Sbjct: 947 KELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLS 1006
Query: 488 LSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDL 547
S + + + A + ++ D + + R RN L +
Sbjct: 1007 ASMRDLI-QGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDL--TRQLRNSTLQCET 1063
Query: 548 TRTPPPPS-STFPKASSESSYLSI----LPKTPEGISEEQRSQELAAMEETR--IVILNN 600
+ + S + L + + + + +E +++L ++ + +N
Sbjct: 1064 INSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123
Query: 601 LEELKQKIKDINDQMDESFREL-----DMECALLDGEQKSETTELMKE-KEILDHLNRKI 654
LEEL+ +++ Q+ ++ +EL D + L + ++ LMKE + L + N KI
Sbjct: 1124 LEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKI 1183
Query: 655 AELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADL 714
+LE+ I +K K++ L E L+ + Y E+ T++ +++L + + D
Sbjct: 1184 EDLEQEIKIQKQKQET-LQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDH 1242
Query: 715 LDVESKHFEDLEFQQLEHE------SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISAL 768
L +++ +LE Q + E + + EK + + L ++QR + + +++++AL
Sbjct: 1243 LILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTAL 1302
Query: 769 KKQANHIVQQAQREQDHFVKEKNNLIMMLQREK 801
+++ + F K + +L+++K
Sbjct: 1303 QEECRAAKAEQATVTSEFESYKVRVHNVLKQQK 1335
Score = 54.3 bits (129), Expect = 7e-07
Identities = 76/304 (25%), Positives = 130/304 (42%), Gaps = 43/304 (14%)
Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
++L+ D +P P + S L LPK + I ++ L ++R L
Sbjct: 2 EDLVQDGVASPATPGTG-------KSKLETLPKE-DLIKFAKKQMMLIQKAKSRCTELEK 53
Query: 601 -LEELKQK-----IKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKI 654
+EEL+ K DI + E L +E A + + S E +K K+ ++ K+
Sbjct: 54 EIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKM 113
Query: 655 AELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDN-CPESMREQLQ--QQLKRD 711
+ K + +++ + +L ++ YSE K L E+M QL+ +QLK
Sbjct: 114 GDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQ 173
Query: 712 ADLLDVESKHFEDLE-----------FQQLEHESRLDEEKENLTQQLLREVAE-----YQ 755
+ D K E++E + Q + ++ DE+KE +TQ L+ + E YQ
Sbjct: 174 NNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQ--LQNIIEANSQHYQ 231
Query: 756 RNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLC--------NL 807
+NI S +E++ LK V++ + + KE I L KENL N+
Sbjct: 232 KNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNI 291
Query: 808 EKKY 811
+KKY
Sbjct: 292 QKKY 295
Score = 50.8 bits (120), Expect = 8e-06
Identities = 159/803 (19%), Positives = 306/803 (38%), Gaps = 178/803 (22%)
Query: 426 MDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEK 485
++ H R+ + L+EQ + + ET LS DS T + ++Q + ++ E
Sbjct: 419 VEQHNREVQS-LKEQHQKEISELN-ETFLS--------DSEKEKLTLMFEIQGLKEQCEN 468
Query: 486 LQLSDEESVFE-----------EALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFT 534
LQ +E++ + + +S+ + L Q + FT
Sbjct: 469 LQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFT 528
Query: 535 PRST----------RNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRS 584
+ N++LLS P ++ YL +S QR
Sbjct: 529 EKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYL---------LSLSQRD 579
Query: 585 QELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALL--------------- 629
L +E + ++ K+K+ +++MD ++ + E L+
Sbjct: 580 TMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNS 639
Query: 630 DGEQK-SETT----ELMKEKEILDH------LNRKIAELEKNIVGEKTK----EKVKLDA 674
+ EQK +E T E +KEK+ D + K+ +K ++ + K E KL +
Sbjct: 640 ELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSS 699
Query: 675 EREKLERLQELYSEQK---------TQLDNCPESMREQ---LQQQLKRD----------- 711
E+++L R E++ QK TQL+ + M E+ L + L+ +
Sbjct: 700 EKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQL 759
Query: 712 -ADLLDVESKHFEDLEFQQL--------EHESRLDEEKENLTQQLLREVAEYQRNIVSRK 762
L ++ S+ ED E + + E ++++EEK NL Q +V E ++ I +
Sbjct: 760 YGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQ 819
Query: 763 EKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCN--LEKKYSSLSGGKGF 820
E+ ++ +++ ++E+ KE + +Q EKE L + LE K ++ K
Sbjct: 820 EESVVQCEELKSLLRDYEQEKVLLRKE----LEEIQSEKEALQSDLLEMKNAN---EKTR 872
Query: 821 PVNPNTLKEGYISVNEINEPCGNS--------------TNLSP----------STQFPAD 856
N N L I V E+++ C S NL P +
Sbjct: 873 LENQNLL----IQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILL 928
Query: 857 ADAVATEPATA--VLASQPQSKEHFRSLEERKKQHKE---GLYLSDTLPRKKTTSSISPH 911
D++A P+ L+S + +E +LE+ K+ +E + L +K+ SS
Sbjct: 929 KDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSS---- 984
Query: 912 FSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSES-RRMLRGYNHQ--QMSEGH 968
R T L S L S+ + + +ES + +L Y Q Q+
Sbjct: 985 -------RKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEK 1037
Query: 969 RQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSAS 1028
+ + F +R + NS +T++ D+ D + + S +
Sbjct: 1038 ERANNFEHRIEDLTRQLRNS---------TLQCETINSDNEDLLARIETLQSNAKLLEVQ 1088
Query: 1029 TSNIARIE-------EMERLLKQ----AHAEKTRLLESREREMEAKKRALEEEKRRREIL 1077
+ R + E E+L K+ HA LE + +++ +K+ L++ + E++
Sbjct: 1089 ILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELV 1148
Query: 1078 EKRLQEETSQRQKLIEKEVKIRE 1100
+K Q+ T ++ + E ++E
Sbjct: 1149 KKDAQQTTLMNMEIADYERLMKE 1171
Score = 35.0 bits (79), Expect = 0.45
Identities = 33/137 (24%), Positives = 58/137 (42%), Gaps = 4/137 (2%)
Query: 959 YNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISA 1018
Y +Q+ +K E T ++ + NS HY + Q + L L + E
Sbjct: 200 YLQKQLDATTDEKKETV--TQLQNIIEANSQHYQKNINSLQE-ELLQLKAIHQEEVKELM 256
Query: 1019 CSPDNISSASTSNIARIEEM-ERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREIL 1077
C + + + I ++ E+ E L+KQ A + + + E E+E ++A + +I
Sbjct: 257 CQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQIC 316
Query: 1078 EKRLQEETSQRQKLIEK 1094
LQE T Q + EK
Sbjct: 317 SILLQENTFVEQVVNEK 333
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 59.7 bits (143), Expect = 2e-08
Identities = 66/259 (25%), Positives = 125/259 (48%), Gaps = 28/259 (10%)
Query: 576 EGISEEQRSQELAAM--EETRI----VILNNLEELKQKIKDINDQMDESFRELDMECALL 629
E I EE++ QE M +E +I I E++ ++ + I Q ++ +R+ E +
Sbjct: 464 EKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQ---EEKIR 520
Query: 630 DGEQKSETTE--LMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYS 687
+ E+K E + +++E + E EK EK E+ K + +K+ R +E
Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIR 580
Query: 688 EQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLE-FQQLEHESRLDEEK----EN 742
EQ+ ++ E +REQ +++ +++ + E K E E Q+ E + R EEK E
Sbjct: 581 EQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEE 640
Query: 743 LTQQLLREVAEYQRNIVSRKEKI----SALKKQANHIVQQAQ--REQDHFVKEKNNLIMM 796
+TQ+ ++ E + + ++EK+ + +Q I +Q + REQ+ ++E+ + M
Sbjct: 641 MTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEM-MQ 699
Query: 797 LQREK-----ENLCNLEKK 810
Q EK E +C E+K
Sbjct: 700 EQEEKMWEQEEKMCEQEEK 718
Score = 46.6 bits (109), Expect = 1e-04
Identities = 51/270 (18%), Positives = 119/270 (44%), Gaps = 33/270 (12%)
Query: 574 TPEGISEEQRS--QELAAMEETRIVILNNLEELKQKIK---------DINDQMDESFREL 622
T E + E+ ++L +E + I N++ELK+K++ + + D +EL
Sbjct: 215 TDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL 274
Query: 623 DMECALLDGE----------QKSETTELMKEKEILDHLNRKIAELEKNI---------VG 663
A L + + + ++ +++E + KI E E+ I
Sbjct: 275 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE 334
Query: 664 EKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFE 723
EK + + ++ E+E+ R QE +K + E M + +++++R +++ + +
Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 394
Query: 724 DLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQR-- 781
+LE + E E ++E++ ++ +RE + Q + +++Q I +Q ++
Sbjct: 395 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMW 454
Query: 782 EQDHFVKEKNNLIMMLQR-EKENLCNLEKK 810
Q+ + E+ + +R E+E + E+K
Sbjct: 455 RQEEKIHEQEKIREEEKRQEQEEMWRQEEK 484
Score = 45.1 bits (105), Expect = 4e-04
Identities = 30/148 (20%), Positives = 75/148 (50%), Gaps = 5/148 (3%)
Query: 602 EELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNI 661
EE +Q+ ++ + +E RE + + + + + + ++ +++E+ K+ E E+ +
Sbjct: 597 EEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKM 656
Query: 662 VGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKH 721
+++ K+ + E + R +E EQ+ ++ E +REQ + +++ + + E K
Sbjct: 657 C----EQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 712
Query: 722 FEDLEFQQLEHESRLDEEKENLTQQLLR 749
E E Q E E ++ ++E + +Q +R
Sbjct: 713 CEQEEKMQ-EQEEKMRRQEEKMWEQEVR 739
Score = 43.5 bits (101), Expect = 0.001
Identities = 45/235 (19%), Positives = 107/235 (45%), Gaps = 21/235 (8%)
Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELM 641
+R +E+ +E +I L ++KI++ ++ E + + E +++ + ++
Sbjct: 380 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE------KRQEQEAKMW 433
Query: 642 KEKEILDHLNRKIAELEKNIVGEKTK----EKVKLDAEREKLERL--QELYSEQKTQLDN 695
+++E + KI E EK + ++ K EK++ + +R++ E + QE ++ ++
Sbjct: 434 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWR 493
Query: 696 CPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQ 755
E M EQ ++ K++ + E K ++ E + R EEK ++ +RE E
Sbjct: 494 QKEKMHEQEEKIRKQEEKVWRQEEK------IREQEEKIREQEEKMWRQEEKIREQEEMW 547
Query: 756 RNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK 810
R E+ +++ + Q+ ++E+ + R++E + E+K
Sbjct: 548 REEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVW---RQEEKIREQEEK 599
Score = 41.2 bits (95), Expect = 0.006
Identities = 49/234 (20%), Positives = 102/234 (43%), Gaps = 46/234 (19%)
Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELM 641
++ +++ EE ++ EE ++ +++ + +E REL E+K E +
Sbjct: 360 EKEEKMRRQEE----MMWEKEEKMRRQEEMMWEKEEKIREL---------EEKMHEQEKI 406
Query: 642 KEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMR 701
+E+E EK EK +E+ K + K+ R +E EQ+ E +R
Sbjct: 407 REQE------------EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE-------EKIR 447
Query: 702 EQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSR 761
EQ ++ +++ + + E E E R ++E+ ++ + E E R
Sbjct: 448 EQEKKMWRQEEKIHEQEKIR---------EEEKRQEQEEMWRQEEKIHEQEEIWRQKEKM 498
Query: 762 KEKISALKKQANHIVQQAQ--REQDHFVKEKNNLIMMLQ---REKENLCNLEKK 810
E+ ++KQ + +Q + REQ+ ++E+ + + RE+E + E+K
Sbjct: 499 HEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEK 552
Score = 40.4 bits (93), Expect = 0.011
Identities = 36/151 (23%), Positives = 72/151 (47%), Gaps = 11/151 (7%)
Query: 580 EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRE---LDMECALLDGEQKSE 636
EE+R ++ M + I E+++++ + I +Q +E RE + E GEQ+ +
Sbjct: 597 EEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQ-EEKIREQEEMTQEQEEKMGEQEEK 655
Query: 637 TTE----LMKEKEILDHLNRKIAELEKNIVGEKTK---EKVKLDAEREKLERLQELYSEQ 689
E + +++E + KI E EK I ++ K ++ + + EK+ +E EQ
Sbjct: 656 MCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 715
Query: 690 KTQLDNCPESMREQLQQQLKRDADLLDVESK 720
+ ++ E MR Q ++ +++ L E K
Sbjct: 716 EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746
Score = 35.8 bits (81), Expect = 0.26
Identities = 25/79 (31%), Positives = 43/79 (54%), Gaps = 7/79 (8%)
Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREIL----EKRLQEETS---QR 1088
E+M R + ++ ++ E E+ E +K +EEKR+ E EKR ++E Q
Sbjct: 377 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 436
Query: 1089 QKLIEKEVKIRERQRAQAR 1107
+K+ E+E KIRE+++ R
Sbjct: 437 EKIREQEEKIREQEKKMWR 455
Score = 35.4 bits (80), Expect = 0.34
Identities = 25/82 (30%), Positives = 46/82 (56%), Gaps = 3/82 (3%)
Query: 1024 ISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQ 1082
+ S S A++EE E + ++ ++ E+ E +++ E+E++ RE EK R Q
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333
Query: 1083 EETSQRQK--LIEKEVKIRERQ 1102
EE +RQ+ + EKE K+R ++
Sbjct: 334 EEKMRRQEEMMWEKEEKMRRQE 355
Score = 35.0 bits (79), Expect = 0.45
Identities = 46/252 (18%), Positives = 103/252 (40%), Gaps = 26/252 (10%)
Query: 653 KIAELEKNIVGE--KTKEKVKLDAEREKLERLQELYSEQKTQLDNC--PESMRE---QLQ 705
K+AE ++ + +T V A K +++ + + T C PE ++ Q Q
Sbjct: 59 KLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQKASHQHQ 118
Query: 706 QQLKRDAD-------LLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI 758
+ L+R+ + +L + + + +L+ E +L +L + ++ +
Sbjct: 119 EALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL-HDSWKFAGEL 177
Query: 759 VSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGK 818
++ KK+A+ +++ +E+D E + + KE L++K + K
Sbjct: 178 EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEK 237
Query: 819 GFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATE--PATAVLASQPQSK 876
E ++V E+ + L P Q A+AD + E +A L +Q +
Sbjct: 238 ---------SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 288
Query: 877 EHFRSLEERKKQ 888
E + L +++++
Sbjct: 289 ELWNRLNQQQEE 300
Score = 34.7 bits (78), Expect = 0.59
Identities = 26/71 (36%), Positives = 41/71 (57%), Gaps = 4/71 (5%)
Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQ--KL 1091
+I+E E +++ EK R E +E E +K +EEK + + + QEET RQ K+
Sbjct: 620 KIQEQEEKIREQE-EKIREQEEMTQEQE-EKMGEQEEKMCEQEEKMQEQEETMWRQEEKI 677
Query: 1092 IEKEVKIRERQ 1102
E+E KIRE++
Sbjct: 678 REQEKKIREQE 688
Score = 33.9 bits (76), Expect = 1.0
Identities = 26/77 (33%), Positives = 41/77 (53%), Gaps = 9/77 (11%)
Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEE------EKRRR--EILEKRLQEET 1085
+I+E E + Q EK R E + RE E K R EE EK RR E++ ++ ++
Sbjct: 308 KIQEWEEKI-QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366
Query: 1086 SQRQKLIEKEVKIRERQ 1102
Q + + EKE K+R ++
Sbjct: 367 RQEEMMWEKEEKMRRQE 383
Score = 33.9 bits (76), Expect = 1.0
Identities = 24/67 (35%), Positives = 40/67 (59%), Gaps = 8/67 (11%)
Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKE 1095
E+ E++ +Q EK R E + +E E K EE+ R +E +++QE Q +K+ E+E
Sbjct: 581 EQEEKVWRQE--EKIREQEEKRQEQEEKMWKQEEKIREQE---EKIQE---QEEKIREQE 632
Query: 1096 VKIRERQ 1102
KIRE++
Sbjct: 633 EKIREQE 639
Score = 33.5 bits (75), Expect = 1.3
Identities = 30/126 (23%), Positives = 59/126 (46%), Gaps = 26/126 (20%)
Query: 577 GISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSE 636
G EE+ ++ M+E + E+++++ K I +Q +E RE +
Sbjct: 650 GEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQ-EEKIREQE------------- 695
Query: 637 TTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNC 696
E+M+E+E K+ E E+ + +++ K+ + EK+ R +E EQ+ +L
Sbjct: 696 --EMMQEQE------EKMWEQEEKMC----EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 743
Query: 697 PESMRE 702
E M+E
Sbjct: 744 EEKMQE 749
Score = 33.1 bits (74), Expect = 1.7
Identities = 23/72 (31%), Positives = 40/72 (55%), Gaps = 3/72 (4%)
Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIE 1093
+I E E K+ EK R E R+ E EAK EE+ R +E + +++ ++++ I
Sbjct: 405 KIREQEE--KRQEEEKIREQEKRQ-EQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH 461
Query: 1094 KEVKIRERQRAQ 1105
++ KIRE ++ Q
Sbjct: 462 EQEKIREEEKRQ 473
Score = 33.1 bits (74), Expect = 1.7
Identities = 21/72 (29%), Positives = 45/72 (62%), Gaps = 6/72 (8%)
Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQEETSQRQ--K 1090
+I E E+ +++ ++ ++ E E E +++ E+E++ E EK + QEE +RQ K
Sbjct: 676 KIREQEKKIRE---QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 732
Query: 1091 LIEKEVKIRERQ 1102
+ E+EV++R+++
Sbjct: 733 MWEQEVRLRQQE 744
Score = 32.7 bits (73), Expect = 2.2
Identities = 16/70 (22%), Positives = 43/70 (61%), Gaps = 2/70 (2%)
Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK--RLQEETSQRQKLIE 1093
EE+ R ++ H ++ ++ + E+ +++ E+E++ RE EK R +E+ +++++
Sbjct: 489 EEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR 548
Query: 1094 KEVKIRERQR 1103
+E K+ E+++
Sbjct: 549 EEEKMHEQEK 558
Score = 32.3 bits (72), Expect = 2.9
Identities = 25/97 (25%), Positives = 49/97 (50%), Gaps = 6/97 (6%)
Query: 1034 RIEEMERLLKQAHAEKTRLLES---REREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1090
+I E E +++ + R E +E+ E +KR +EE R+E +E Q++K
Sbjct: 438 KIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEK 497
Query: 1091 LIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVE 1127
+ E+E KIR+++ R + +R+++ +R E
Sbjct: 498 MHEQEEKIRKQEEKVWRQEEK---IREQEEKIREQEE 531
Score = 32.3 bits (72), Expect = 2.9
Identities = 26/71 (36%), Positives = 40/71 (56%), Gaps = 5/71 (7%)
Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQEETSQRQKLIEK 1094
E+ E++ KQ EK E + RE E K R EE+ R+E EK R QEE + ++ + +
Sbjct: 500 EQEEKIRKQE--EKVWRQEEKIREQEEKIREQEEKMWRQE--EKIREQEEMWREEEKMHE 555
Query: 1095 EVKIRERQRAQ 1105
+ KI E ++ Q
Sbjct: 556 QEKIWEEEKRQ 566
Score = 32.3 bits (72), Expect = 2.9
Identities = 32/104 (30%), Positives = 51/104 (49%), Gaps = 16/104 (15%)
Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQEETSQRQ--- 1089
+I E E +Q EK E + RE E K + EE+ R +E EK R QEE +Q Q
Sbjct: 592 KIREQEEK-RQEQEEKMWKQEEKIREQEEKIQEQEEKIREQE--EKIREQEEMTQEQEEK 648
Query: 1090 ------KLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVE 1127
K+ E+E K++E++ R + +R+++ +R E
Sbjct: 649 MGEQEEKMCEQEEKMQEQEETMWRQEEK---IREQEKKIREQEE 689
Score = 32.0 bits (71), Expect = 3.8
Identities = 21/76 (27%), Positives = 42/76 (55%), Gaps = 10/76 (13%)
Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEK---------RRREILEKRLQEETS 1086
EEM R ++ H E+ ++ E +R+ + K +EEK R+ E + ++ ++
Sbjct: 544 EEMWREEEKMH-EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQE 602
Query: 1087 QRQKLIEKEVKIRERQ 1102
Q +K+ ++E KIRE++
Sbjct: 603 QEEKMWKQEEKIREQE 618
Score = 31.6 bits (70), Expect = 5.0
Identities = 26/75 (34%), Positives = 38/75 (50%), Gaps = 9/75 (12%)
Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEE------EKRRR--EILEKRLQEET 1085
+I E E +++ EK R E E E K R EE EK RR E++ ++ ++
Sbjct: 322 KIREQEEKIREQE-EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 380
Query: 1086 SQRQKLIEKEVKIRE 1100
Q + + EKE KIRE
Sbjct: 381 RQEEMMWEKEEKIRE 395
Score = 31.6 bits (70), Expect = 5.0
Identities = 23/64 (35%), Positives = 36/64 (56%), Gaps = 6/64 (9%)
Query: 1048 EKTRLLESREREMEAKKRALEE-----EKRRREILEK-RLQEETSQRQKLIEKEVKIRER 1101
EK R E E E K R EE E++ RE+ EK QE+ ++++ ++E KIRE+
Sbjct: 363 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 422
Query: 1102 QRAQ 1105
++ Q
Sbjct: 423 EKRQ 426
Score = 31.2 bits (69), Expect = 6.5
Identities = 21/77 (27%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 1034 RIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQEETSQRQ--K 1090
+I E E++ ++ ++ + +E ++ ++ ++++ E EK R QEE RQ K
Sbjct: 459 KIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEK 518
Query: 1091 LIEKEVKIRERQRAQAR 1107
+ E+E KIRE++ R
Sbjct: 519 IREQEEKIREQEEKMWR 535
Score = 30.8 bits (68), Expect = 8.5
Identities = 24/82 (29%), Positives = 42/82 (51%), Gaps = 14/82 (17%)
Query: 1036 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK-RLQEETSQRQ----- 1089
E+ E++ +Q + ++ E E +++ E+EK+ RE EK R QEE Q Q
Sbjct: 651 EQEEKMCEQ----EEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 706
Query: 1090 ----KLIEKEVKIRERQRAQAR 1107
K+ E+E K++E++ R
Sbjct: 707 EQEEKMCEQEEKMQEQEEKMRR 728
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.347
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,573,611
Number of Sequences: 37866
Number of extensions: 2376058
Number of successful extensions: 24724
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 328
Number of HSP's successfully gapped in prelim test: 1108
Number of HSP's that attempted gapping in prelim test: 12257
Number of HSP's gapped (non-prelim): 9512
length of query: 1253
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1139
effective length of database: 13,930,794
effective search space: 15867174366
effective search space used: 15867174366
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.