Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 197313728
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|197313728 pleckstrin homology-like domain, family B, member
2 isoform b [Homo sapiens]
(1237 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197313728 pleckstrin homology-like domain, family B, member 2... 2439 0.0
gi|21955172 pleckstrin homology-like domain, family B, member 2 ... 2385 0.0
gi|197313732 pleckstrin homology-like domain, family B, member 2... 2364 0.0
gi|197313730 pleckstrin homology-like domain, family B, member 2... 2364 0.0
gi|221219026 pleckstrin homology-like domain, family B, member 1... 657 0.0
gi|221219024 pleckstrin homology-like domain, family B, member 1... 652 0.0
gi|38424073 pleckstrin homology-like domain, family B, member 1 ... 652 0.0
gi|157266264 pleckstrin homology-like domain, family B, member 3... 201 5e-51
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 67 8e-11
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 65 5e-10
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 62 3e-09
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 60 1e-08
gi|29788755 SET binding factor 2 [Homo sapiens] 59 2e-08
gi|239735519 SET binding factor 1 [Homo sapiens] 58 6e-08
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 57 8e-08
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 57 1e-07
gi|38044112 restin isoform b [Homo sapiens] 56 2e-07
gi|4506751 restin isoform a [Homo sapiens] 56 2e-07
gi|21735548 centrosomal protein 2 [Homo sapiens] 56 2e-07
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 56 2e-07
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 55 3e-07
gi|118498356 kinectin 1 isoform a [Homo sapiens] 55 4e-07
gi|33620775 kinectin 1 isoform a [Homo sapiens] 55 4e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 54 7e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 54 7e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 54 7e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 54 7e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 54 7e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 54 7e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 54 7e-07
>gi|197313728 pleckstrin homology-like domain, family B, member 2
isoform b [Homo sapiens]
Length = 1237
Score = 2439 bits (6321), Expect = 0.0
Identities = 1237/1237 (100%), Positives = 1237/1237 (100%)
Query: 1 MEEEDTKREVPKEDGVGDVQHFDSSKIMEEHSYIQKELDLQNGSLEEDSVVHSVENDSQN 60
MEEEDTKREVPKEDGVGDVQHFDSSKIMEEHSYIQKELDLQNGSLEEDSVVHSVENDSQN
Sbjct: 1 MEEEDTKREVPKEDGVGDVQHFDSSKIMEEHSYIQKELDLQNGSLEEDSVVHSVENDSQN 60
Query: 61 MMESLSPKKYSSSLRFKANGDYSGSYLTLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQ 120
MMESLSPKKYSSSLRFKANGDYSGSYLTLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQ
Sbjct: 61 MMESLSPKKYSSSLRFKANGDYSGSYLTLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQ 120
Query: 121 FSYDGTDKNIPMKPPTPLLNTTSSLSGYPLGRADFDHYTGRDSERALRLSEKPPYSKYSS 180
FSYDGTDKNIPMKPPTPLLNTTSSLSGYPLGRADFDHYTGRDSERALRLSEKPPYSKYSS
Sbjct: 121 FSYDGTDKNIPMKPPTPLLNTTSSLSGYPLGRADFDHYTGRDSERALRLSEKPPYSKYSS 180
Query: 181 RHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISRSGAASMPSSPKQARKMSI 240
RHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISRSGAASMPSSPKQARKMSI
Sbjct: 181 RHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISRSGAASMPSSPKQARKMSI 240
Query: 241 QDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLP 300
QDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLP
Sbjct: 241 QDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLP 300
Query: 301 PRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPA 360
PRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPA
Sbjct: 301 PRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPA 360
Query: 361 SPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEA 420
SPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEA
Sbjct: 361 SPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEA 420
Query: 421 DLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETI 480
DLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETI
Sbjct: 421 DLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETI 480
Query: 481 LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDS 540
LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDS
Sbjct: 481 LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDS 540
Query: 541 LPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPK 600
LPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPK
Sbjct: 541 LPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPK 600
Query: 601 TPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ 660
TPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ
Sbjct: 601 TPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ 660
Query: 661 KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRL 720
KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRL
Sbjct: 661 KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRL 720
Query: 721 DEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMM 780
DEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMM
Sbjct: 721 DEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMM 780
Query: 781 LQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPAD 840
LQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPAD
Sbjct: 781 LQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPAD 840
Query: 841 ADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSAT 900
ADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSAT
Sbjct: 841 ADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSAT 900
Query: 901 MGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN 960
MGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN
Sbjct: 901 MGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN 960
Query: 961 RTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIE 1020
RTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIE
Sbjct: 961 RTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIE 1020
Query: 1021 EMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEV 1080
EMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEV
Sbjct: 1021 EMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEV 1080
Query: 1081 KIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMGGK 1140
KIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMGGK
Sbjct: 1081 KIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMGGK 1140
Query: 1141 IKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFS 1200
IKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFS
Sbjct: 1141 IKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFS 1200
Query: 1201 VKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1237
VKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Sbjct: 1201 VKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1237
>gi|21955172 pleckstrin homology-like domain, family B, member 2
isoform c [Homo sapiens]
Length = 1210
Score = 2385 bits (6180), Expect = 0.0
Identities = 1210/1210 (100%), Positives = 1210/1210 (100%)
Query: 28 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 87
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
Query: 88 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 147
TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
Query: 148 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 207
YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
Query: 208 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 267
NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
Query: 268 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 327
YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
Query: 328 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 387
YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
Query: 388 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 447
GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
Query: 448 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 507
GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
Query: 508 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 567
KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
Query: 568 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 627
DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
Query: 628 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 687
LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
Query: 688 IVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKE 747
IVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKE
Sbjct: 661 IVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKE 720
Query: 748 KISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
KISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN
Sbjct: 721 KISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 780
Query: 808 PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE 867
PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE
Sbjct: 781 PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE 840
Query: 868 ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 927
ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL
Sbjct: 841 ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 900
Query: 928 AAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDT 987
AAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDT
Sbjct: 901 AAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDT 960
Query: 988 LSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAK 1047
LSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAK
Sbjct: 961 LSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAK 1020
Query: 1048 KRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR 1107
KRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR
Sbjct: 1021 KRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR 1080
Query: 1108 SHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHET 1167
SHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHET
Sbjct: 1081 SHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHET 1140
Query: 1168 KLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVT 1227
KLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVT
Sbjct: 1141 KLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVT 1200
Query: 1228 GAEGYTHFLL 1237
GAEGYTHFLL
Sbjct: 1201 GAEGYTHFLL 1210
>gi|197313732 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 2364 bits (6126), Expect = 0.0
Identities = 1210/1253 (96%), Positives = 1210/1253 (96%), Gaps = 43/1253 (3%)
Query: 28 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 87
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
Query: 88 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 147
TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
Query: 148 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 207
YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
Query: 208 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 267
NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
Query: 268 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 327
YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
Query: 328 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 387
YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
Query: 388 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 447
GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
Query: 448 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 507
GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
Query: 508 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 567
KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
Query: 568 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 627
DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
Query: 628 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 687
LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
Query: 688 IVGEKTK-------------------------------------------DADLLDVESK 704
IVGEKTK DADLLDVESK
Sbjct: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
Query: 705 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ
Sbjct: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
Query: 765 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 824
REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP
Sbjct: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
Query: 825 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 884
CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP
Sbjct: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
Query: 885 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 944
RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN
Sbjct: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960
Query: 945 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1004
HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS
Sbjct: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020
Query: 1005 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1064
PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR
Sbjct: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080
Query: 1065 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1124
LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS
Sbjct: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140
Query: 1125 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1184
ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD
Sbjct: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200
Query: 1185 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1237
HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Sbjct: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253
>gi|197313730 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 2364 bits (6126), Expect = 0.0
Identities = 1210/1253 (96%), Positives = 1210/1253 (96%), Gaps = 43/1253 (3%)
Query: 28 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 87
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
Query: 88 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 147
TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
Query: 148 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 207
YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
Query: 208 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 267
NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
Query: 268 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 327
YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
Query: 328 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 387
YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
Query: 388 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 447
GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
Query: 448 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 507
GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
Query: 508 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 567
KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
Query: 568 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 627
DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
Query: 628 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 687
LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
Query: 688 IVGEKTK-------------------------------------------DADLLDVESK 704
IVGEKTK DADLLDVESK
Sbjct: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
Query: 705 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ
Sbjct: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
Query: 765 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 824
REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP
Sbjct: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
Query: 825 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 884
CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP
Sbjct: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
Query: 885 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 944
RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN
Sbjct: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960
Query: 945 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1004
HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS
Sbjct: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020
Query: 1005 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1064
PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR
Sbjct: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080
Query: 1065 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1124
LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS
Sbjct: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140
Query: 1125 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1184
ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD
Sbjct: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200
Query: 1185 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1237
HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Sbjct: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253
>gi|221219026 pleckstrin homology-like domain, family B, member 1
isoform b [Homo sapiens]
Length = 1319
Score = 657 bits (1695), Expect = 0.0
Identities = 390/838 (46%), Positives = 513/838 (61%), Gaps = 124/838 (14%)
Query: 434 PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 492
P RERK+SI+ IS DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D
Sbjct: 570 PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629
Query: 493 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
G ++ I + L L+ P LA
Sbjct: 630 ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663
Query: 553 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
S T R + E SD SST S++ + E +
Sbjct: 664 SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711
Query: 613 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
E+ A+EE R +L ++E+LK ++K++ Q+ ES RE +ME ALL GE+++E L KE++
Sbjct: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQK 771
Query: 673 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
+D L K+ LE I E+ K+A+ L+ E+K FEDLEFQQLE ESR++EE+E Q LL
Sbjct: 772 AVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
Query: 733 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 792
R AE R+I RKE+++ L QA I QA +E + ++KN + +LQ+EKE L LE
Sbjct: 832 RSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLE 891
Query: 793 KKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAV 852
++Y SL+GG+ FP +TLKE Y S + G +T+ P T+
Sbjct: 892 RRYHSLTGGRPFPKTTSTLKEVYRSKMD-----GEATSPLPRTR---------------- 930
Query: 853 LASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLP 912
S LP +SS S S AT+GRS +PK+ L
Sbjct: 931 ---------------------------SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALL 963
Query: 913 LGQSNSCGSVLPPSLAAMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVYL 970
N GS LP +LAA +D E++R L + Q + E R+ +E + A+E+
Sbjct: 964 T--QNGTGS-LPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW 1020
Query: 971 NSFH-----------YPD---HSYK-------------DQAFDTLSLDSSDSMETSIS-- 1001
++ H +P HS + A+DTLSL+SSDSMETSIS
Sbjct: 1021 DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG 1080
Query: 1002 ---ACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRR 1058
ACSPDN+SSAS ++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RRR
Sbjct: 1081 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR 1140
Query: 1059 EILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNID 1118
E +E+RLQ E+++RQ+L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +D
Sbjct: 1141 EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD 1200
Query: 1119 TCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAI 1178
TC HV ++ K CRG+L+KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQAI
Sbjct: 1201 TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI 1260
Query: 1179 EEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFL 1236
EEVYYDHL++A KSPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIVTGAEGYT F+
Sbjct: 1261 EEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFM 1318
>gi|221219024 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 652 bits (1683), Expect = 0.0
Identities = 392/850 (46%), Positives = 524/850 (61%), Gaps = 90/850 (10%)
Query: 434 PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 492
P RERK+SI+ IS DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D
Sbjct: 570 PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629
Query: 493 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
G ++ I + L L+ P LA
Sbjct: 630 ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663
Query: 553 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
S T R + E SD SST S++ + E +
Sbjct: 664 SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711
Query: 613 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
E+ A+EE R +L ++E+LK ++K++ Q+ ES RE +ME ALL GE+++E L KE++
Sbjct: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQK 771
Query: 673 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
+D L K+ LE I E+ K+A+ L+ E+K FEDLEFQQLE ESR++EE+E Q LL
Sbjct: 772 AVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
Query: 733 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 792
R AE R+I RKE+++ L QA I QA +E + ++KN + +LQ+EKE L LE
Sbjct: 832 RSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLE 891
Query: 793 KKYSSLSGGKGFPVNPNTLKE-GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATA 851
++Y SL+GG+ FP +TLKE + + ++ ++ PA A ++ P
Sbjct: 892 RRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLP 951
Query: 852 VLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHL 911
AS+ + +RS + + S LP +SS S S AT+GRS +PK+ L
Sbjct: 952 AKASR--QLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSAL 1009
Query: 912 PLGQSNSCGSVLPPSLAAMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVY 969
N GS LP +LAA +D E++R L + Q + E R+ +E + A+E+
Sbjct: 1010 LT--QNGTGS-LPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQ 1066
Query: 970 LNSFH-----------YPD---HSYK-------------DQAFDTLSLDSSDSMETSIS- 1001
++ H +P HS + A+DTLSL+SSDSMETSIS
Sbjct: 1067 WDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSIST 1126
Query: 1002 ----ACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR 1057
ACSPDN+SSAS ++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RR
Sbjct: 1127 GGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRR 1186
Query: 1058 REILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNI 1117
RE +E+RLQ E+++RQ+L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +
Sbjct: 1187 REQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGV 1246
Query: 1118 DTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQA 1177
DTC HV ++ K CRG+L+KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQA
Sbjct: 1247 DTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQA 1306
Query: 1178 IEEVYYDHLKNANK-----------SPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIV 1226
IEEVYYDHL++A K SPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIV
Sbjct: 1307 IEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIV 1366
Query: 1227 TGAEGYTHFL 1236
TGAEGYT F+
Sbjct: 1367 TGAEGYTQFM 1376
>gi|38424073 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 652 bits (1683), Expect = 0.0
Identities = 392/850 (46%), Positives = 524/850 (61%), Gaps = 90/850 (10%)
Query: 434 PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 492
P RERK+SI+ IS DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D
Sbjct: 570 PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629
Query: 493 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
G ++ I + L L+ P LA
Sbjct: 630 ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663
Query: 553 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
S T R + E SD SST S++ + E +
Sbjct: 664 SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711
Query: 613 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
E+ A+EE R +L ++E+LK ++K++ Q+ ES RE +ME ALL GE+++E L KE++
Sbjct: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQK 771
Query: 673 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
+D L K+ LE I E+ K+A+ L+ E+K FEDLEFQQLE ESR++EE+E Q LL
Sbjct: 772 AVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
Query: 733 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 792
R AE R+I RKE+++ L QA I QA +E + ++KN + +LQ+EKE L LE
Sbjct: 832 RSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLE 891
Query: 793 KKYSSLSGGKGFPVNPNTLKE-GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATA 851
++Y SL+GG+ FP +TLKE + + ++ ++ PA A ++ P
Sbjct: 892 RRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLP 951
Query: 852 VLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHL 911
AS+ + +RS + + S LP +SS S S AT+GRS +PK+ L
Sbjct: 952 AKASR--QLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSAL 1009
Query: 912 PLGQSNSCGSVLPPSLAAMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVY 969
N GS LP +LAA +D E++R L + Q + E R+ +E + A+E+
Sbjct: 1010 LT--QNGTGS-LPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQ 1066
Query: 970 LNSFH-----------YPD---HSYK-------------DQAFDTLSLDSSDSMETSIS- 1001
++ H +P HS + A+DTLSL+SSDSMETSIS
Sbjct: 1067 WDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSIST 1126
Query: 1002 ----ACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR 1057
ACSPDN+SSAS ++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RR
Sbjct: 1127 GGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRR 1186
Query: 1058 REILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNI 1117
RE +E+RLQ E+++RQ+L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +
Sbjct: 1187 REQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGV 1246
Query: 1118 DTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQA 1177
DTC HV ++ K CRG+L+KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQA
Sbjct: 1247 DTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQA 1306
Query: 1178 IEEVYYDHLKNANK-----------SPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIV 1226
IEEVYYDHL++A K SPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIV
Sbjct: 1307 IEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIV 1366
Query: 1227 TGAEGYTHFL 1236
TGAEGYT F+
Sbjct: 1367 TGAEGYTQFM 1376
>gi|157266264 pleckstrin homology-like domain, family B, member 3
[Homo sapiens]
Length = 640
Score = 201 bits (510), Expect = 5e-51
Identities = 111/212 (52%), Positives = 130/212 (61%), Gaps = 31/212 (14%)
Query: 1019 IEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEK 1078
I MERLL+QA AE+ RLL++R E +R E
Sbjct: 455 IAHMERLLQQAMAERERLLKAR----EGTRRGTEGSSG---------------------- 488
Query: 1079 EVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMG 1138
A P T P DLR H+E GHN + C HV ++ CRG L+KMG
Sbjct: 489 -----PAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMG 543
Query: 1139 GKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLT 1198
G+IKTW+KRWF FDR R +YYADK ETKLKGVIYFQAIEEVYYDHL+ A KSPNP LT
Sbjct: 544 GRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLT 603
Query: 1199 FSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAE 1230
F VKT++R++YMVAPSPEAMRIWMDVIVT A+
Sbjct: 604 FCVKTYERLFYMVAPSPEAMRIWMDVIVTAAD 635
Score = 67.4 bits (163), Expect = 8e-11
Identities = 95/418 (22%), Positives = 165/418 (39%), Gaps = 109/418 (26%)
Query: 577 TPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIK 636
TPP + P AS+ S + G + + Q+L A+ TR+ ++ +Q++K
Sbjct: 75 TPPIAMAATPPASTSSR------EGVRGAARRLQGQQLEAL--TRVALM------EQRVK 120
Query: 637 DINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHL------------------N 678
++ Q E E+++E ALL GE E +E+E L L
Sbjct: 121 ELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQ 180
Query: 679 RKIAELEKNIVG--EKTKDA-----------------------DLLDVESKHFEDLEFQQ 713
R++++ + G ++ + A + LDV + +EDLEFQQ
Sbjct: 181 RRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQ 240
Query: 714 LEHESRLDEEKEN---------LTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
LE ESR +EE + Q+L +A+++R + + +I L++Q + +Q
Sbjct: 241 LERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGAL--QHRIRVLEEQLKSLGEQMA 298
Query: 765 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 824
E ++K + L +E+ L L + L G G + +EP
Sbjct: 299 AESRGLSRKKEEALQALSQERSRLLEL----NCLQGTPG---------------GDFSEP 339
Query: 825 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 884
T L + + D + + A A A+ P S F Q GL + +LP
Sbjct: 340 NPALTKLLFTQK--TDRQLLVLQDAVAHSAATPTSSCLFS--VHSSLQGSIGLQRTGSLP 395
Query: 885 RKK--------TTSSISPHFSSATMGRSITP----KAHLPL------GQSNSCGSVLP 924
RK+ + +S H + + ++ P PL G+ NSCG++ P
Sbjct: 396 RKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHP 453
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 67.4 bits (163), Expect = 8e-11
Identities = 139/673 (20%), Positives = 269/673 (39%), Gaps = 94/673 (13%)
Query: 458 RQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQ-KINKELEKL-QL 515
+Q +E L +Q E+ R D LS T+V ++ ++N+ EK+ QL
Sbjct: 592 KQAQENLHDQVQEQKAHLR-----------AAQDRVLSLETSVNELNSQLNESKEKVSQL 640
Query: 516 SDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLT 575
+ E L+S + R D D A + Q +T+ D++ + L
Sbjct: 641 DIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQ--NALQDKQQELNKITTQLDQVTAKLQ 698
Query: 576 RTPPPPSSTFPKASS-ESSYLSILPKTPEGISE----EQRSQELAAMEETRIVILNNLEE 630
S + YLS+ KT E + E S E+ A +E L +L++
Sbjct: 699 DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA---LQDLQQ 755
Query: 631 LKQKIKDINDQMDESFRELDMECAL-----LDGEQKSETTELMKEKEILDHLNRKIAELE 685
+Q D+ + E ++L+ME + LD ++KSE E +K+K ++I + +
Sbjct: 756 QRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD 815
Query: 686 KNIVGEKTK--DADLLDVESKHFEDLEFQQLEHESRLDE------EKENLTQQLLREVAE 737
+ ++TK +L + +L+ ++E E+ + E + ++ L +E
Sbjct: 816 FETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE 875
Query: 738 YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSS 797
+++ K I L+K + Q Q + ++ +KE+ L L++EKE L+ + +S
Sbjct: 876 FEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNS 935
Query: 798 LSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPST-QFPADADAVATEPATAVL--- 853
+ + NTLK+ + E + GN L S+ Q +A+ E AVL
Sbjct: 936 MQ--EQLIQAQNTLKQ---NEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKT 990
Query: 854 ------------ASQPQSKE---------HFRSLEERKKQHKEGLY--LSDTLPRKKTTS 890
A+Q + E ++ +E KQ + Y S+ L ++
Sbjct: 991 ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLK 1050
Query: 891 SISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSE 950
S+ S + + +G N L + A + +DS + QQ+ E
Sbjct: 1051 SVEEKLS---LAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKK-------EQQLQE 1100
Query: 951 GHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISS 1010
+ + + + +N K + + + E + +
Sbjct: 1101 RCKALQDIQKEKSLKEKELVNE--------KSKLAEIEEIKCRQEKEITKLNEELKSHKL 1152
Query: 1011 ASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRL-QEET 1069
S I +++ ++LL Q E + + ++ K A+E+EKR ++IL+ ++ +EE
Sbjct: 1153 ESIKEITNLKDAKQLLIQQKLE-------LQGKADSLKAAVEQEKRNQQILKDQVKKEEE 1205
Query: 1070 SQRQKLIEKEVKI 1082
+++ IEKE K+
Sbjct: 1206 ELKKEFIEKEAKL 1218
Score = 61.2 bits (147), Expect = 6e-09
Identities = 144/732 (19%), Positives = 285/732 (38%), Gaps = 87/732 (11%)
Query: 413 GSVEFDEADLESLRQASGTPQPA---LRERKSSISSISGR--DDLMDYHRRQREERLREQ 467
G V A+L+SL Q Q +++ K + + ++ D + EER +
Sbjct: 128 GLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE 187
Query: 468 EMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 527
E+ + E + + L +EDV + KEL ++Q + E
Sbjct: 188 AAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERE 247
Query: 528 SPDTRYRCHRKDSLPDADLASCGSLSQSSA-----------------SFFTPRSTRNDEL 570
S + C + S + A+ L A S + +N L
Sbjct: 248 SEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTL 307
Query: 571 LSDLTRTPPPPSSTFPKASSESSYLSILPKT--PEGISEEQRSQELAAMEET--RI-VIL 625
+L + + K + ES + T + + +Q L+A E + RI V L
Sbjct: 308 TENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL 367
Query: 626 NNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELE 685
+ E QK+K+ +++ ++ L E L +++ + ++ + ++ L+ K+ E E
Sbjct: 368 SEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427
Query: 686 KNIVGEKTKDADLLDVESKHFEDLEFQQLEHE---SRLDEE-KENLT-----QQLLREVA 736
+ + + + + S+ D E Q + + SRL+E+ KE +T Q L +
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK 487
Query: 737 EYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK-- 794
+ + + ++ +A ++A + ++Q R+ ++ NL +LQ+ KEN+ LEK+
Sbjct: 488 QQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547
Query: 795 --YSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAV 852
Y+ + G+G N L+E ++ E T L+ + +++ A E
Sbjct: 548 DLYAKIQAGEGETAVLNQLQEKNHTLQE------QVTQLTEKLKNQSESHKQAQENLHDQ 601
Query: 853 LASQPQSKEHFRSLEER--------------KKQHKEGLYLSDTLPRKKTTSSISPHFSS 898
+ Q K H R+ ++R + KE + D + KT +S +
Sbjct: 602 VQEQ---KAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA--EA 656
Query: 899 ATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEF 958
A + + HL Q+ A K E ++ + Q++ + K E
Sbjct: 657 AKTAQRADLQNHLDTAQN-----------ALQDKQQELNKITTQLD--QVTAKLQDKQEH 703
Query: 959 YNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSIS-ACSPDNISSASTSNIA 1017
++ S Y + + ++ L+ +DS+E S + ++ N
Sbjct: 704 CSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE-ADSLEVKASKEQALQDLQQQRQLNTD 762
Query: 1018 RIEEMERLLKQAHAEK-----TRL-LESREREMEAKKRALEEEKRRREILEKRLQEETSQ 1071
L KQ EK TRL L+ + +E+ K+ L +++ ++IL++ E SQ
Sbjct: 763 LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDF-ETLSQ 821
Query: 1072 RQKLIEKEVKIR 1083
K+ +E+ R
Sbjct: 822 ETKIQHEELNNR 833
Score = 48.5 bits (114), Expect = 4e-05
Identities = 78/395 (19%), Positives = 162/395 (41%), Gaps = 52/395 (13%)
Query: 420 ADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLET 479
A L+ T Q AL++++ ++ I+ + D + + ++E + E E +
Sbjct: 660 AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYK---- 715
Query: 480 ILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKD 539
+ LS E+++ K+LE L + S E+AL + + +
Sbjct: 716 -----------EKYLSLEQKTEELEGQIKKLEADSLEVKASK-EQALQDLQQQRQLNTDL 763
Query: 540 SLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILP 599
L +L+ + + S STR DL + S K + + IL
Sbjct: 764 ELRATELSKQLEMEKEIVS-----STR-----LDLQKKSEALESIKQKLTKQEEEKQILK 813
Query: 600 KTPEGISEEQRSQ-------------ELAAMEETRIVILNNLEELKQKIKDINDQMDESF 646
+ E +S+E + Q EL ++ + ++ L +K K+ ++D + S
Sbjct: 814 QDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK 873
Query: 647 RELDME-----CALLDGEQKSETTELMKEKEI-LDHLNRKIAELEKNIVGEKTKDADLLD 700
E + E A+LD E+ + EL + ++ +++ ++ EL+K++ EK L
Sbjct: 874 SEFEKENQKGKAAILDLEKTCK--ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQL-- 929
Query: 701 VESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIV 760
++ Q ++ ++ L ++ E QQL + E +++ +K++I AL+ + V
Sbjct: 930 --KLELNSMQEQLIQAQNTL-KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAV 986
Query: 761 QQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
Q ++ ++ L EKE + L+ Y
Sbjct: 987 LQKTELENKLQQQLTQAAQELAAEKEKISVLQNNY 1021
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 64.7 bits (156), Expect = 5e-10
Identities = 102/496 (20%), Positives = 201/496 (40%), Gaps = 79/496 (15%)
Query: 618 EETRIVILNNLEELKQKIKDINDQMDE---SFRELDMECALLDGEQKSETTELM------ 668
EE ++ N ++++ I+D+ +Q+DE + ++L +E + + K E++
Sbjct: 935 EERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQN 994
Query: 669 ----KEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKH---FEDLEFQQLEHESRLD 721
KEK++++ +IAE + E+ K +L + +K DLE ++L+ E +
Sbjct: 995 SKFIKEKKLMED---RIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLE-ERLKKEEKTR 1050
Query: 722 EEKENLTQQLLREVAEYQRNIVSRKEKISALKKQA---NHIVQQAQREQDHFVKEKNNLI 778
+E E ++L E + Q I + +I LK Q +Q A D KNN +
Sbjct: 1051 QELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL 1110
Query: 779 MMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFP 838
+++ + + L++ + S + N ++ ++E E T+
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASR------NKAEKQKRDLSEELEAL--------KTELE 1156
Query: 839 ADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTT-SSISPHFS 897
D A + Q + E ++LEE K H+ + D R T +S
Sbjct: 1157 DTLDTTAAQQELRTKREQ-EVAELKKALEEETKNHEA--QIQDMRQRHATALEELSEQLE 1213
Query: 898 SATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN----HQQMSEGHR 953
A ++ K L N + L + +SE +R H ++SEG R
Sbjct: 1214 QAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDR 1273
Query: 954 QKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSA-- 1011
+ E + + N D++ T + I A
Sbjct: 1274 LRVELAEKASKLQN------------------------ELDNVSTLLEEAEKKGIKFAKD 1309
Query: 1012 STSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRAL----EEEKRRREILEKR--- 1064
+ S +++++ + LL++ +K L SR R++E +K +L EEE+ R+ LEK+
Sbjct: 1310 AASLESQLQDTQELLQEETRQKLNL-SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLA 1368
Query: 1065 LQEETSQRQKLIEKEV 1080
LQ + + +K ++ ++
Sbjct: 1369 LQSQLADTKKKVDDDL 1384
Score = 48.5 bits (114), Expect = 4e-05
Identities = 140/707 (19%), Positives = 270/707 (38%), Gaps = 94/707 (13%)
Query: 394 SLLAGESDRVFATRRNFSCGSVEF--DEADLESLRQASGTPQPALRERKSSISSISGRDD 451
S L E D V ++F D A LES Q + Q L+E ++S R
Sbjct: 1283 SKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT---QELLQEETRQKLNLSSRIR 1339
Query: 452 LMDYHRRQREERLREQEMER--LERQRLETILSLCAEYTKPDSRLSTGTTVEDVQK-INK 508
++ + +E+ E+E R LE+Q L L K D L T ++E+ +K + K
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399
Query: 509 ELEKL-QLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 567
+ E L Q +E+++ + L R + D D D + AS + +
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH------QRQVASNLEKKQKKF 1453
Query: 568 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQE-LAAMEETRIVILN 626
D+LL++ + +A +E+ K + +S + +E L A EE
Sbjct: 1454 DQLLAEEKSISARYAEERDRAEAEAR-----EKETKALSLARALEEALEAKEEFE----R 1504
Query: 627 NLEELKQKIKDI---NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAE 683
++L+ ++D+ D + ++ EL+ L+ + + T+L + ++ L
Sbjct: 1505 QNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLR 1564
Query: 684 LEKNIVGEKT---KDADLLDVESKHFEDLEFQQL-EHESRLDEEKENLTQQLLREVAEYQ 739
LE N+ K +D D +++ + L +Q+ E E+ L++E++ R +A
Sbjct: 1565 LEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ------RALA--- 1615
Query: 740 RNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML---QREKENLCNLEKKYS 796
V+ K+K+ K ++ A + +D +K+ L + QRE E +
Sbjct: 1616 ---VASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIF 1672
Query: 797 SLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPAD--ADAVATEPA--TAV 852
+ S + LK + ++ E +S + D AD + + +A+
Sbjct: 1673 AQS-----KESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727
Query: 853 LASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLP 912
L + + + LEE ++ + + L + RK T
Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL----------------------- 1764
Query: 913 LGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQ---QMSEGHRQKSEFYNRTASESNVY 969
Q ++ + L +A K +R+ L N + ++ E + T S
Sbjct: 1765 --QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAK 1822
Query: 970 LNSFHYP-DHSYKDQAFDTLSLDSSDS------METSISACSPDNISSASTSNIARIEEM 1022
+ + K++A + ++ M+ D AR++++
Sbjct: 1823 IGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQL 1882
Query: 1023 ERLLKQAHAEKTRLLESR---EREMEAKKRALEEEKRRREILEKRLQ 1066
+R L++A E TR SR +RE++ A E R L+ RL+
Sbjct: 1883 KRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929
Score = 48.1 bits (113), Expect = 5e-05
Identities = 112/586 (19%), Positives = 229/586 (39%), Gaps = 108/586 (18%)
Query: 607 EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLD---GEQKSE 663
EE++++ LA + + V++++LEE +K + +++++ R+LD E L E +++
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1077
Query: 664 TTEL-----MKEKE--------------------ILDHLNRKIAELEKNIVGEK------ 692
EL KE+E ++ L +IAEL+++ EK
Sbjct: 1078 IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137
Query: 693 -------TKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSR 745
+++ + L E + D Q E ++ ++E L + L E ++ I
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197
Query: 746 KEKISALKKQANHIVQQAQREQDHFVKEKNNL----------IMMLQREKENLCNLEKK- 794
+++ + ++ + ++QA+R + + K K L + +LQ+ K + KK
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL 1257
Query: 795 -------YSSLSGGKGFPV----NPNTLKEGYISVNEINEP--------CGNSTNLSPST 835
++ +S G V + L+ +V+ + E ++ +L
Sbjct: 1258 DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL 1317
Query: 836 QFPADADAVATEPATAVLASQPQSKEHFRSLEE--------RKKQHKEGLYLSDTL--PR 885
Q + T + + Q +E SL+E RK K+ L L L +
Sbjct: 1318 QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTK 1377
Query: 886 KKTTSSISPHFSSATMGRSITPKAHL---PLGQSNSCGSVLPPSLAAMAKDSESRRMLRG 942
KK + S + + A L + L + + ++ + +
Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLD 1437
Query: 943 YNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISA 1002
+ Q S +++ +F A E ++ S Y + +D+A +++ E A
Sbjct: 1438 HQRQVASNLEKKQKKFDQLLAEEKSI---SARYAEE--RDRA-------EAEAREKETKA 1485
Query: 1003 CSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESRE------REMEAKKRALEEEKR 1056
S ++ A + EE ER KQ A+ L+ S++ E+E KRALE++
Sbjct: 1486 LS---LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQV- 1541
Query: 1057 RREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKE 1102
E + +L+E + Q + ++++ +A R L R E
Sbjct: 1542 --EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDE 1585
Score = 47.4 bits (111), Expect = 9e-05
Identities = 73/375 (19%), Positives = 158/375 (42%), Gaps = 39/375 (10%)
Query: 438 ERKSSISSISGRDDLM--DYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS 495
E+ +++ I + ++M D R ++E QE+E+ +R+ L E T +++
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK-------LDGETTDLQDQIA 1072
Query: 496 TGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 555
++Q EL KLQL+ +E + AL D H+ ++L +++
Sbjct: 1073 ------ELQAQIDEL-KLQLAKKEEELQGALARGDDE-TLHKNNALKVVRELQA-QIAEL 1123
Query: 556 SASFFTPRSTRN----------DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGI 605
F + +++RN +EL + T +T + + + + + +
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183
Query: 606 SEEQRSQE--LAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSE 663
EE ++ E + M + L L E ++ K ++++ + L+ + + E E
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD----NKELACE 1239
Query: 664 TTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEE 723
L + K +H +K+ + + + K + D L VE +L++ S L EE
Sbjct: 1240 VKVLQQVKAESEHKRKKL-DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEE 1298
Query: 724 KENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQR 783
E + ++ A + + +E + +Q ++ + ++ ++ EKN+L +
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEE----EKNSLQEQQEE 1354
Query: 784 EKENLCNLEKKYSSL 798
E+E NLEK+ +L
Sbjct: 1355 EEEARKNLEKQVLAL 1369
Score = 44.7 bits (104), Expect = 6e-04
Identities = 42/190 (22%), Positives = 91/190 (47%), Gaps = 16/190 (8%)
Query: 608 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 667
+ + +EL ++E + + LEE+++K + + ++ + +L E L E + L
Sbjct: 855 QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF-AEAEEMRARL 913
Query: 668 MKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESK---HFEDLEFQQLEHESRLDEEK 724
+K+ L+ + + +LE + E+ ++ L + + K H +DLE Q LDEE
Sbjct: 914 AAKKQELEEI---LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ-------LDEE- 962
Query: 725 ENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE 784
E Q+L E + I +E+I L+ Q + +++ + +D + E ++ + + +
Sbjct: 963 EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR-IAECSSQLAEEEEK 1021
Query: 785 KENLCNLEKK 794
+NL + K
Sbjct: 1022 AKNLAKIRNK 1031
Score = 38.9 bits (89), Expect = 0.031
Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 11/87 (12%)
Query: 1011 ASTSNIARIEEMERLL---KQAHAEKTRLLESREREMEAKKRALEEEKRRREI----LEK 1063
A T A EEM L KQ E LESR E E + + L+ EK++ + LE+
Sbjct: 898 AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957
Query: 1064 RLQEETSQRQKL----IEKEVKIRERQ 1086
+L EE RQKL + E KI++ +
Sbjct: 958 QLDEEEGARQKLQLEKVTAEAKIKKME 984
Score = 38.5 bits (88), Expect = 0.040
Identities = 140/771 (18%), Positives = 302/771 (39%), Gaps = 103/771 (13%)
Query: 418 DEADLESLRQASGTP-QPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER-Q 475
D D + +Q T + + E K ++ + + RQR E+ E+LE+ +
Sbjct: 1157 DTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216
Query: 476 RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYR 534
R + L + + D++ V+ +Q++ E E + + V E A +S R R
Sbjct: 1217 RFKANLEKNKQGLETDNK-ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR 1275
Query: 535 CH--RKDSLPDADLASCGSLSQSS----------ASFFTPRSTRNDELLSDLTRTPPPPS 582
K S +L + +L + + A+ + ELL + TR S
Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335
Query: 583 STFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETR---------IVILNNLEELKQ 633
S + E + L + E + Q LA + + + +LEE K+
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 634 K-IKD---INDQMDE---SFRELDMECALLDGEQKSETTELMKEKEILDHLNRK------ 680
K +KD ++ +++E ++ +L+ L E T +L ++++ +L +K
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 681 -IAELEKNIVGEKTKDADLLDVESKHFEDL----------------EFQQLEHESRLD-- 721
+AE EK+I ++ D + E++ E EF++ + R D
Sbjct: 1456 LLAE-EKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514
Query: 722 -------------EEKENLTQQLLREVAEYQRNIVSRKEKISA-----LKKQANHIVQQA 763
E E + L ++V E + + ++++ A L+ + N +A
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574
Query: 764 QREQDHFVK-----EKNNLIMMLQREKENLCNLEKKYSSL--SGGKGFPVNPNTLKEGYI 816
Q E+D + EK L++ RE E E+K +L + K ++ L+
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIE 1634
Query: 817 SVNEI-NEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKE 875
+ N+ +E L + A + A +S++ +SLE Q +E
Sbjct: 1635 AANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE 1694
Query: 876 GLYLSDTLPR--KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKD 933
L S+ R ++ ++ +++ G+S L + L +A + ++
Sbjct: 1695 ELASSERARRHAEQERDELADEITNSASGKSAL------LDEKRR----LEARIAQLEEE 1744
Query: 934 SESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSS 993
E + N + +++ R+ + + +E ++ D++ + L +
Sbjct: 1745 LEEEQS----NMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAK 1800
Query: 994 -DSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALE 1052
+E ++ + I SA + I ++EE + A +L+ E++++ +E
Sbjct: 1801 LQELEGAVKSKFKATI-SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVE 1859
Query: 1053 EEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKED 1103
+E+R + ++++ E+ + R K ++++++ E + +A R L +D
Sbjct: 1860 DERRHADQYKEQM-EKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909
Score = 30.8 bits (68), Expect = 8.4
Identities = 22/83 (26%), Positives = 43/83 (51%), Gaps = 11/83 (13%)
Query: 1040 REREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQR------AQARPL 1093
+E E++AK L + K ++ +E L+E + Q+L+E++ + E+ + A+A +
Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 1094 TRYLPVRKEDF-----DLRSHVE 1111
L +K++ DL S VE
Sbjct: 910 RARLAAKKQELEEILHDLESRVE 932
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 62.0 bits (149), Expect = 3e-09
Identities = 150/717 (20%), Positives = 285/717 (39%), Gaps = 89/717 (12%)
Query: 422 LESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETIL 481
LE+L+Q + L+ K +I S + L+ +E L+EQ ERL Q LE I
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLT----SEKEALQEQLDERL--QELEKIK 334
Query: 482 SL-CAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDS 540
L AE TK ++L D + + ++LE+ ++ ++ +T+ + H
Sbjct: 335 DLHMAEKTKLITQL------RDAKNLIEQLEQ----------DKGMVIAETKRQMHETLE 378
Query: 541 LPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPK 600
+ + ++A S + +T+ +EL ++ KA S + +
Sbjct: 379 MKEEEIAQLRSRIKQM-------TTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431
Query: 601 TPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ 660
+ +EQ EE RI + L +KQ++ D+ + E + A L Q
Sbjct: 432 KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEE------QIAKL---Q 482
Query: 661 KSETTEL-MKEKEILDHLNRKIAELEK--NIVGEKTKDADL-LDVESKHFEDLEFQQLEH 716
K EL KE+E+ L + E ++ + EK++ L + E + E L ++LE
Sbjct: 483 KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELEL 542
Query: 717 ESR-LDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKN 775
+ + + E EN + L +E Y+ I+ E S+L+K Q++ H EKN
Sbjct: 543 QKKAILTESENKLRDLQQEAETYRTRIL---ELESSLEKSLQENKNQSKDLAVHLEAEKN 599
Query: 776 ----NLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGY-ISVNEINEPCGNSTN 830
+ +M+++ K L +L+ + +L + LK+ Y + ++ E C
Sbjct: 600 KHNKEITVMVEKHKTELESLKHQQDAL-----WTEKLQVLKQQYQTEMEKLREKCEQEKE 654
Query: 831 L---SPSTQFPADADAVATEPATAVLASQPQ----SKEHFRSLEERKKQHKEGLYLSDTL 883
F A + + + + Q + S E L+ R K +E L D
Sbjct: 655 TLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQT 714
Query: 884 PRKKTTSSISPHFSS---ATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRML 940
+ K SI + + + ++ L + K+ + + +
Sbjct: 715 DKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERD-KHLK 773
Query: 941 RGYNHQQMSEGHRQKSEFYNRTASES----NVYLNSFHYPDHSYKDQAFD----TLSLDS 992
H + E ++SE + AS Y ++ H +Y++Q L L++
Sbjct: 774 EHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLET 833
Query: 993 SDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALE 1052
+ T A T A +++ L++Q LE + EME K ++L
Sbjct: 834 ERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ--------LEKQNSEMEQKVKSLT 885
Query: 1053 EEKRRREILEKRLQEETSQRQKLIEKE---VKIRERQRAQARPLTRYLPVRKEDFDL 1106
+ + LE +E+ +Q L+EKE +++RE Q+ + LT+ L +++ +
Sbjct: 886 QVYESK--LEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHI 940
Score = 58.2 bits (139), Expect = 5e-08
Identities = 73/372 (19%), Positives = 161/372 (43%), Gaps = 37/372 (9%)
Query: 436 LRERKSSISSISGRDDLMDYHRRQREERLREQE--MERLERQRLETI--LSLCAEYTKPD 491
++ K+ I S+ + + +++ E+E + +L+++ E I ++L E K +
Sbjct: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELK-E 1364
Query: 492 SRLSTGTTVEDVQKINKELEK-LQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCG 550
++ + + + +N +L+ + LS++E+ D +C D + D
Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEE-KCELLDQVQDLSF-KVD 1422
Query: 551 SLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQR 610
+LS+ S + D+ + + S F + + L I E +
Sbjct: 1423 TLSKEKISALE----QVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI--------QLELK 1470
Query: 611 SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKE 670
S+E +E ++ L++ ++ + +M++ +++ + + L+ E KS+T +M
Sbjct: 1471 SKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM-- 1528
Query: 671 KEILDHLNRKIAELEKNIVGEKTKDADLL-DVESKHFEDLEFQQLEHESRLDEEKENLTQ 729
E+ DH+ +K E+E + E K+ + D+E K Q+L+H L EEK+N +
Sbjct: 1529 -ELEDHITQKTIEIES--LNEVLKNYNQQKDIEHKEL----VQKLQHFQELGEEKDNRVK 1581
Query: 730 QLLREVAEYQRNIVSRKEKISALKKQANHI---VQQAQRE----QDHFVKEKNNLIMMLQ 782
+ ++ + + S K ++ KK+ H+ V+ + E +D E + L+
Sbjct: 1582 EAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELK 1641
Query: 783 REKENLCNLEKK 794
R+ E KK
Sbjct: 1642 RKAEQKIAAIKK 1653
Score = 49.7 bits (117), Expect = 2e-05
Identities = 107/561 (19%), Positives = 218/561 (38%), Gaps = 76/561 (13%)
Query: 600 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
KT E + +Q EL ++ +L +L++++ + DQ D+ +EL+ +
Sbjct: 674 KTLEKLDVKQT--ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNH 731
Query: 660 QKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL-LDVESKHFEDLEFQQLEHES 718
+ + ++KE E+ K + + N + K+ D L H E+LE E
Sbjct: 732 HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEG 791
Query: 719 RLDEEKENL-------------TQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQR 765
L + L T+ ++A+ Q+ ++ + + L KQ + Q +
Sbjct: 792 ELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKD 851
Query: 766 EQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS---------GGKGFPVNPNTLKEGYI 816
K + ++Q+ ++ +E+K SL+ G K L E
Sbjct: 852 VCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKEN 911
Query: 817 SVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQS--KEHFRSLEERKKQHK 874
+ ++ E G + TQ A E + +L + ++ K + +E+ K++ K
Sbjct: 912 MILQMRE--GQKKEIEILTQ-----KLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 964
Query: 875 EGLYLSDTLPRK--KTTSSISPHFSSATMGRSITPKAH----LPLGQSNSCGSVLPPSLA 928
E + +TL +K + + + + S K L + Q+NS G S A
Sbjct: 965 E---MQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGI----SDA 1017
Query: 929 AMAKDSESRRMLRGYNHQQMSEGHRQK----SEFYNRTASESNVYLNSFHYPDHSYKDQA 984
++ + + + ++E HR++ + + ++ L H K+Q
Sbjct: 1018 VSRLETNQKEQI-----ESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQE 1072
Query: 985 FDTLSLD------SSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLE 1038
L + M I+ + + +T N E++ LKQ A L +
Sbjct: 1073 VAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLN-----ELQEQLKQKSAHVNSLAQ 1127
Query: 1039 SREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLP 1098
E +++A LE + L K L+E T +++L+E ++ + E + + LT L
Sbjct: 1128 D-ETKLKAHLEKLEVD------LNKSLKENTFLQEQLVELKM-LAEEDKRKVSELTSKLK 1179
Query: 1099 VRKEDF-DLRSHVETAGHNID 1118
E+F L+S E + +++
Sbjct: 1180 TTDEEFQSLKSSHEKSNKSLE 1200
Score = 49.7 bits (117), Expect = 2e-05
Identities = 142/670 (21%), Positives = 257/670 (38%), Gaps = 100/670 (14%)
Query: 459 QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDE 518
++EE +E + E + +T L+ E K S + +D K+ LEKL++
Sbjct: 1086 EKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSA-HVNSLAQDETKLKAHLEKLEVDLN 1144
Query: 519 ESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDL---- 574
+S+ E + +L + S T + DE L
Sbjct: 1145 KSLKENTFLQEQL------------VELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSH 1192
Query: 575 ---TRTPPPPSSTFPKASSESSY-LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEE 630
++ S F K S E + L I K E + E + ++ + IL+ +
Sbjct: 1193 EKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISH 1252
Query: 631 LKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILD----HLNRKIAELEK 686
+ + + + + L C + E +++ +L +E+ L+ ++ E E
Sbjct: 1253 CQHRTTKVKEAL------LIKTCTV--SELEAQLRQLTEEQNTLNISFQQATHQLEEKEN 1304
Query: 687 NIVGEKTKDADLLDVESKHFEDLEFQQLE-HESRLDEEKENLTQQLLREVAE-------Y 738
I K D+ES E Q+ ++ + EKE+ QL +E++E
Sbjct: 1305 QIKSMKA------DIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLM 1358
Query: 739 QRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE-KENLCNLEKKYSS 797
+ + +K +IS+L KQ + Q Q + EK I L+++ E C L +
Sbjct: 1359 KEELKEKKVEISSLSKQLTDLNVQLQNSIS--LSEKEAAISSLRKQYDEEKCELLDQVQD 1416
Query: 798 LSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQP 857
LS F V+ TL + IS E + N + ++ A + T+ V Q
Sbjct: 1417 LS----FKVD--TLSKEKISALEQVDDWSNKFS-----EWKKKAQSRFTQHQNTVKELQI 1465
Query: 858 Q----SKEHFRS-------LEERKKQHK-----EGLYLSDTLPRKKTTSSISPHFSSATM 901
Q SKE + EE +Q+K +G D +K S++ S T
Sbjct: 1466 QLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQT- 1524
Query: 902 GRSITPKAHLPLG--QSNSCGSVLPPSLAAMAKDSESRRMLRGYNH-QQMSE--GHRQKS 956
R + + H+ + S VL KD E + +++ H Q++ E +R K
Sbjct: 1525 ARIMELEDHITQKTIEIESLNEVLKNY--NQQKDIEHKELVQKLQHFQELGEEKDNRVKE 1582
Query: 957 EFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNI 1016
E+ VY + K + + ++L S S E + A D + S S + +
Sbjct: 1583 AEEKILTLENQVYSMK---AELETKKKELEHVNL-SVKSKEEELKALE-DRLESESAAKL 1637
Query: 1017 ARIEEM---------ERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQE 1067
A ++ ++LL Q ++ + + E + L+E +R ILE++L+
Sbjct: 1638 AELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKS 1697
Query: 1068 -ETSQRQKLI 1076
E+SQ + LI
Sbjct: 1698 VESSQSETLI 1707
Score = 45.8 bits (107), Expect = 3e-04
Identities = 111/550 (20%), Positives = 209/550 (38%), Gaps = 61/550 (11%)
Query: 605 ISEEQRSQELAAME-----ETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
+S + + +EL A+E E+ + + +QKI I Q+ E + +
Sbjct: 1613 LSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTES 1672
Query: 660 QKSETTELMKEKEILDH-LNRKIAELEKN-----IVGEKTKDADLLDVESKHFEDLEFQQ 713
SE ++E+E H L K+ +E + IV K+ E + + Q
Sbjct: 1673 HLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAY-TEQEEADSQGCVQ 1731
Query: 714 LEHESRLDEEKENLTQQ--LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFV 771
+E ++ + NLT++ LL+ V + + VS ++ ++ ++ A+ +Q
Sbjct: 1732 KTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQH--- 1788
Query: 772 KEKNNLIMMLQREKENLCNLEKKYSSL-------SGGKGFPVNPNTLKEGYISVNEINEP 824
E ++I LQ E E KKYS + GGK L+ + V + +
Sbjct: 1789 -EDQSMIGHLQEELEEK---NKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQE 1844
Query: 825 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSK-EHFRSLEERKKQHKEGLYLSDTL 883
+ + D+ V + V + SK E ++L++ ++K L +
Sbjct: 1845 KELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENT 1904
Query: 884 PRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGY 943
K + + P S + + L + L + + KD RMLR
Sbjct: 1905 EEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREK--QKLGKEIVRLQKDL---RMLRKE 1959
Query: 944 NHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISAC 1003
+ Q++ ++ + + L H + F+T +E +I
Sbjct: 1960 HQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIK-- 2017
Query: 1004 SPDNISSASTSNIARIE----EMERLLKQAHAEK-----------TRLLESREREMEAKK 1048
+ I+ A +E E +LLK+ AEK +L++RE EM AK
Sbjct: 2018 --ETINKAQEVEAELLESHQEETNQLLKKI-AEKDDDLKRTAKRYEEILDAREEEMTAKV 2074
Query: 1049 RALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRS 1108
R L+ + E L+K+ Q++ Q + V I E Q A+ T + ++ + R
Sbjct: 2075 RDLQTQ---LEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFRE 2131
Query: 1109 HVETAGHNID 1118
+ HN++
Sbjct: 2132 QI----HNLE 2137
Score = 44.7 bits (104), Expect = 6e-04
Identities = 44/193 (22%), Positives = 87/193 (45%), Gaps = 19/193 (9%)
Query: 595 LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMEC- 653
L IL K + EE+ QE +E L + LKQ +++ N Q+ + +EL+M
Sbjct: 1964 LEILKKEYDQEREEKIKQEQEDLE------LKHNSTLKQLMREFNTQLAQKEQELEMTIK 2017
Query: 654 ALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQ 713
++ Q+ E L +E + L +KIAE + ++ + ++LD E++ +
Sbjct: 2018 ETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDARE---EEMTAKV 2074
Query: 714 LEHESRLDEEKENLTQQLLRE---------VAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
+ +++L+E ++ Q+L +E + E Q + + IS K + +Q
Sbjct: 2075 RDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIH 2134
Query: 765 REQDHFVKEKNNL 777
+D K + N+
Sbjct: 2135 NLEDRLKKYEKNV 2147
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 60.1 bits (144), Expect = 1e-08
Identities = 78/399 (19%), Positives = 179/399 (44%), Gaps = 57/399 (14%)
Query: 436 LRERKSSISSISGRDDLMDYHRR----QREERLREQEMERLERQRLETILSLCAEYTKPD 491
+ E K+ +I+ +++MD + + EE E +E + S+ A+
Sbjct: 611 IEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEME------VRSVVAD----T 660
Query: 492 SRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS--- 548
+ + G+ V+D K+ +++K + S+ +E ++ ++ + +P ++ S
Sbjct: 661 DQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG 720
Query: 549 -----CGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPE 603
GSLS++ + P S E +D +S+ S SS+LS K
Sbjct: 721 ENKEEIGSLSKTE-TILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLS-KTKDSG 778
Query: 604 GISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSE 663
IS ++ ++ +++TR I++ +E K + D D EL L ++ E
Sbjct: 779 SISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDS-DSKTEEL----RFLRRQELRE 833
Query: 664 TTELMKEKE-ILDHLNRKIAE--------LEKNIVGEKTK-DADLLDVESKHFEDLEFQQ 713
L KE++ LN K+ + E+ ++ +K + D ++ ++E + + +E +
Sbjct: 834 LRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLE 893
Query: 714 LEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI-------------SALKKQANHIV 760
EH +RL +E + + + +E++++Q + +RK+++ +K++ +
Sbjct: 894 QEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELA 953
Query: 761 QQAQREQDHFVKEK-----NNLIMMLQREKENLCNLEKK 794
Q ++ FV+++ +L ++Q++K L N+E++
Sbjct: 954 QSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERE 992
Score = 53.1 bits (126), Expect = 2e-06
Identities = 125/620 (20%), Positives = 247/620 (39%), Gaps = 77/620 (12%)
Query: 505 KINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASC--GSLSQS-----SA 557
++ +E+E + DEE E +L P + K + D +AS LSQ+ S
Sbjct: 310 EVTEEVEDGKEEDEEEETENSLPIPAS------KRASSDLSIASSEEDKLSQNACILESV 363
Query: 558 SFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAM 617
S T RS D+L S + P K E I+E +L AM
Sbjct: 364 SEKTERSNSEDKLNSKILNEKPTTDEP--------------EKAVEDINEHITDAQLEAM 409
Query: 618 EETR---IVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL------- 667
E VI N E + K++++ D D+ +++ ++ +G++ + L
Sbjct: 410 TELHDRTAVIKENEREKRPKLENLPDTEDQETVDIN---SVSEGKENNIMITLETNIEHN 466
Query: 668 MKEKEILDHLNRKIAELEKNIVGEKTKDADL--LDVESKHFEDLEFQQLEHESRLDEEKE 725
+K +E D +++ E K I E+ KD L +D+ S+ + E +S + KE
Sbjct: 467 LKSEEEKDQEKQQMFE-NKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKE 525
Query: 726 NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREK 785
+ TQ+ L E + Q++++S + + A+ + Q+ ++D ++N +
Sbjct: 526 D-TQEKLGEDDKTQKDVISNTSDVIGTCEAAD-VAQKV--DEDSAEDTQSNDGKEVVEVG 581
Query: 786 ENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVA 845
+ L N G K P+ + +NEI E ++ S +
Sbjct: 582 QKLINKPMVGPEAGGTKEVPIKE------IVEMNEIEEGKNKEQAINSSENIMDINEEPG 635
Query: 846 TEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSI 905
T + S + RS+ Q G + D K T+ I +
Sbjct: 636 TTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDA---SKVTTQIDKEKKEIPVSIKK 692
Query: 906 TPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQM-----SEGHRQKSEFYN 960
P+ + + Q VL PS+ + E++ + + + SE ++
Sbjct: 693 EPEVTV-VSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSG 751
Query: 961 R--TASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP---DNIS-SASTS 1014
TA S++ LN K + ++SL + + ++ D + S +TS
Sbjct: 752 TGSTADTSSIDLN-LSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTS 810
Query: 1015 NI-----ARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEET 1069
I ++ EE+ R L++ + R L+ E+ A+++ + +++RE + +R ++E
Sbjct: 811 KIVTDSDSKTEEL-RFLRRQELRELRFLQKEEQR--AQQQLNSKLQQQREQIFRRFEQEM 867
Query: 1070 SQRQKLIEKEVKIRERQRAQ 1089
+++ ++E++ E+Q+ Q
Sbjct: 868 MSKKRQYDQEIENLEKQQKQ 887
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 59.3 bits (142), Expect = 2e-08
Identities = 56/228 (24%), Positives = 89/228 (39%), Gaps = 18/228 (7%)
Query: 1000 ISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRRE 1059
+S PD A TS + IE++E L QA + +L E +++ + R
Sbjct: 1631 VSCTQPD----ALTSLFSEIEKLEHKLNQAPEKWQQLWERVTVDLKEEPRT--------- 1677
Query: 1060 ILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDT 1119
R Q S+ ++ + +++ P + + + VE + +
Sbjct: 1678 ---DRSQRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEEQNSSISPSNGVERRAATLYS 1734
Query: 1120 CYHVSITE-KTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAI 1178
Y E ++ G L K G +K WK RWFV D K YY +T KG I +
Sbjct: 1735 QYTSKNDENRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEV 1794
Query: 1179 EEVY-YDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1225
E V A K + F +KT R+Y A ++ + WMD I
Sbjct: 1795 EMVIPAGPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDKI 1842
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 57.8 bits (138), Expect = 6e-08
Identities = 34/99 (34%), Positives = 48/99 (48%), Gaps = 1/99 (1%)
Query: 1128 KTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVY-YDHL 1186
++ G L K G +K WK RWFV D+ K YY + +T+ KGVI +E V
Sbjct: 1788 RSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPT 1847
Query: 1187 KNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1225
A K+ + F VKT R+Y A + + W+D I
Sbjct: 1848 MGAPKTVDEKAFFDVKTTRRVYNFCAQDVPSAQQWVDRI 1886
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 57.4 bits (137), Expect = 8e-08
Identities = 134/685 (19%), Positives = 267/685 (38%), Gaps = 99/685 (14%)
Query: 449 RDDLMDYHRRQREERLREQEMER-------LERQRLETILSLCAEYTKPDSRLSTGTTVE 501
RDDL Q++ + E ++E LE+++ ++ L + + +L
Sbjct: 2016 RDDL------QKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069
Query: 502 DVQKINKELEKLQLSDEESVFEEAL-----MSPDTRYRCHRKDSLPD---ADLASCGSLS 553
D Q I++E E+ E E+ L P + ++ + L + C L
Sbjct: 2070 DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129
Query: 554 QSSASFFTPRSTRNDEL------LSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISE 607
S RN+E+ + +L + + TF K + ++ K PE E
Sbjct: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK-PELSLE 2188
Query: 608 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 667
Q E A++ I NLEE ++ ++ + +E ++L M+ + QK E+T
Sbjct: 2189 VQLQAERDAIDRKEKEI-TNLEEQLEQFREELENKNEEVQQLHMQLEI----QKKESTTR 2243
Query: 668 MKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHES-----RLDE 722
++E E + L + ++EK +G K++D + + +H +F Q+ E +L+E
Sbjct: 2244 LQELEQENKLFKD--DMEK--LGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNE 2299
Query: 723 EKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ---REQDHFVKEKNNLIM 779
+ L QQL ++ + I + E I L+ Q ++ + R ++ +++ N +I
Sbjct: 2300 QVTKLQQQL--KITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
Query: 780 MLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISV-NEINEPCGNSTNLSPSTQFP 838
LQ+E N+ G+ +N ++L E S+ ++++ L +
Sbjct: 2358 KLQQELANI------------GQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETA 2405
Query: 839 ADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFS- 897
+ Q + SL K+ +E + ++P +I H S
Sbjct: 2406 NEEMTFMKNVLKETNFKMNQLTQELFSL----KRERESVEKIQSIPENSVNVAID-HLSK 2460
Query: 898 ---------SATMGRSITPKAHLPLGQSNSCGSV-------LPPSLAAMAKDSESR---R 938
+ +S+ + + + N GS+ L AKD E +
Sbjct: 2461 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2520
Query: 939 MLRGYNHQQMSEGHRQKSEFYN---------RTASESNVYLNSFHYPDHSYKDQAFDTLS 989
++ Q E + + N A S + L + +++ Q T+S
Sbjct: 2521 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQ--EYAKFCQDNQTIS 2578
Query: 990 LDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKR 1049
+ + +++ D + S ++ RI E+E + + H T L+ +E+ A+K
Sbjct: 2579 SEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMH---TSLILEKEQVEIAEKN 2635
Query: 1050 ALEEEKRRREILEKRLQEETSQRQK 1074
LE+EK+ E+ + E QR+K
Sbjct: 2636 VLEKEKKLLELQKLLEGNEKKQREK 2660
Score = 52.0 bits (123), Expect = 4e-06
Identities = 40/200 (20%), Positives = 97/200 (48%), Gaps = 24/200 (12%)
Query: 607 EEQRSQELAAMEETRIVILNNLEEL--------------KQKIKDINDQMDESFREL--- 649
+E+ +EL + E + + LE+L +Q I + +++E+ + L
Sbjct: 509 KEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTV 568
Query: 650 -DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFE 707
D++ ++ + + EL E E+ ++ + ++ E EKN V ++ ++ ++E +
Sbjct: 569 EDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQ 628
Query: 708 DLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI-VSRKEKISALKKQANHIVQQAQRE 766
L HE L + KE+L + + + + N+ + K++I L+ + + ++ Q E
Sbjct: 629 LL----FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFE 684
Query: 767 QDHFVKEKNNLIMMLQREKE 786
+D+ + ++N LI+ + + K+
Sbjct: 685 KDNLITKQNQLILEISKLKD 704
Score = 50.1 bits (118), Expect = 1e-05
Identities = 124/684 (18%), Positives = 270/684 (39%), Gaps = 134/684 (19%)
Query: 502 DVQKINKELEKLQLS------DEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 555
+++++N+ELE+++++ + FE A+ D G ++Q
Sbjct: 170 EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRD-------------------GIITQL 210
Query: 556 SASFFTPRSTRNDELLSDLTRTPPPP-----------SSTFPKASSESSYLSILPKTPEG 604
+A+ R +++ + L T S T ++ S+ +L +
Sbjct: 211 TANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQI 270
Query: 605 ISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSET 664
++ +Q+ +E + LE+ ++K +D Q+ SF + ++ ++ ++K E
Sbjct: 271 LTHQQQLEEQDHL----------LEDYQKKKEDFTMQI--SFLQEKIKVYEMEQDKKVEN 318
Query: 665 T---ELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLD 721
+ E+ +++ I++ LN KI E EK + K K L K +L+ Q ++ +
Sbjct: 319 SNKEEIQEKETIIEELNTKIIEEEKKTLELKDK----LTTADKLLGELQEQIVQKNQEIK 374
Query: 722 EEKENLT-------------QQLLREVAEYQR----------NIVSRKE-----KISALK 753
K LT +QL+ V E Q+ +IV R E K+ L+
Sbjct: 375 NMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLR 434
Query: 754 KQANHIVQQ--AQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTL 811
+ + + Q Q +Q+ + + M R K + N + YS+++ VN + +
Sbjct: 435 AELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT------VNEDQI 488
Query: 812 KEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEE--- 868
K +++NE+N ++ S + + + E + +E S E+
Sbjct: 489 KLMNVAINELNIKLQDTN--SQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQR 546
Query: 869 -RKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAH----------LPLGQSN 917
R+ ++ L++ T + SA+ R H L + +
Sbjct: 547 ARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKE 606
Query: 918 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPD 977
+VL + + E R ++H++ ++ E +R E HY
Sbjct: 607 K-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYK- 664
Query: 978 HSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTS---NIARIEEMERLLKQAHAEKT 1034
Q D L + S +ET DN+ + I++++++++ L + +E+
Sbjct: 665 -----QQIDGLQNEMSQKIETM--QFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEM 717
Query: 1035 RL-----------LESREREMEAKKRALEEEKRRREILEKRLQE-ETSQRQKLIEKEVK- 1081
L L E+E ++ ++E + + E+LEK+++E E ++K + E +
Sbjct: 718 TLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAEN 777
Query: 1082 --IRERQRAQARPLTRYLPVRKED 1103
+++ ++ L + PV +E+
Sbjct: 778 SILKDEKKTLEDMLKIHTPVSQEE 801
Score = 45.4 bits (106), Expect = 3e-04
Identities = 98/456 (21%), Positives = 184/456 (40%), Gaps = 86/456 (18%)
Query: 417 FDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLER 474
+ + + S++Q S +P L ERK+ I++IS DL+ + QRE + + Q E
Sbjct: 2965 YSDGEDHSIQQVS---EPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSD 3021
Query: 475 QRLETILSLCAEYTKPDSRL---------STGTT-------------VEDVQKINKELEK 512
R E +L+L + + S L + GTT E + +E
Sbjct: 3022 WRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMEC 3081
Query: 513 LQLSDEESVFEE------ALMSPDTRYRCHRKDSLPDADLASCGSLSQSS--------AS 558
LQ +D S+ E + + ++ P +L + S S
Sbjct: 3082 LQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3141
Query: 559 FFTPRSTRND-----------ELLSDLTRTPPPPSSTFPKASS-----ESSYLSILPKTP 602
R+T EL S+L +T +T E+ L + KT
Sbjct: 3142 SMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTD 3201
Query: 603 EG-------ISEEQRSQELA-AMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECA 654
E SE+++S+EL A+E+ + + + E K++++D+ + ES ++ +++
Sbjct: 3202 EVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSL-ESQKQRNLQLN 3260
Query: 655 LL---------DGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL---LDVE 702
LL + +QK E+ ++ + ++ + R + EL+ + EK + ++ LD E
Sbjct: 3261 LLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL-ELQVLLESEKVRIREMSSTLDRE 3319
Query: 703 SKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ 762
+ L+ +SR E+L ++L +++ E IV + K + + + +
Sbjct: 3320 RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETE--KYKLDSLQTR 3377
Query: 763 AQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 798
Q E+D V K LQ E+E +KK L
Sbjct: 3378 QQMEKDRQVHRKT-----LQTEQEANTEGQKKMHEL 3408
Score = 45.1 bits (105), Expect = 4e-04
Identities = 82/387 (21%), Positives = 165/387 (42%), Gaps = 45/387 (11%)
Query: 421 DLESLRQAS--GTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 478
+LE+L+Q S G + R SS + +G ++ + E+ +E+E++R
Sbjct: 1659 ELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVE----EQTFKEKELDRKPEDVPP 1714
Query: 479 TILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRK 538
ILS + R + + KI E+ K + EE++ L D +
Sbjct: 1715 EILS--------NERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSS 1766
Query: 539 DSL-----PDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPS--STFPKASSE 591
SL +A + SC + + DE + + + P + + + K + E
Sbjct: 1767 ASLIWRSEAEASVKSCVHEEHTRVT---------DESIPSYSGSDMPRNDINMWSKVTEE 1817
Query: 592 SSYLS--ILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 649
+ LS ++ G + ++EL +R+ +E+L + I + + Q++ + +
Sbjct: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAA--VEKLLEAISETSSQLEHA-KVT 1874
Query: 650 DMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDV---ESKHF 706
E QK E TE +K +E L + + + + E +K ++D E F
Sbjct: 1875 QTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLF 1934
Query: 707 EDLEFQQLEHESRLDEE---KENLTQQLLREVAEYQ--RNIVSRKEKISALKKQANHIVQ 761
E ++ + RL++E N Q+L E + Q R ++SR+++ A+K +A + Q
Sbjct: 1935 ERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKE--AMKAEAGPVEQ 1992
Query: 762 QAQREQDHFVKEKNNLIMMLQREKENL 788
Q +E + +KEK + ++ +++L
Sbjct: 1993 QLLQETEKLMKEKLEVQCQAEKVRDDL 2019
Score = 44.7 bits (104), Expect = 6e-04
Identities = 83/414 (20%), Positives = 176/414 (42%), Gaps = 55/414 (13%)
Query: 415 VEFDEADLESLRQASGTPQPALRERKSSISSISG-RDDLMDYHRRQREERLREQ------ 467
+ F ++ RQ + L E S+S++ + +++ ++E L+ +
Sbjct: 537 LSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNY 596
Query: 468 --EMERLERQRLETILSLCAEYTKPD-SRLSTGTTVEDVQKINKELEKLQLSDEESVFEE 524
++E LE+++ +L AE + + RL T ++++K E L++ ++ E+
Sbjct: 597 KIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINI-EK 654
Query: 525 ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSST 584
+ Y+ + D L + ++ + T + ++L+ ++++ S
Sbjct: 655 LKDNLGIHYK-QQIDGLQNEMSQKIETMQFEKDNLIT----KQNQLILEISKLKDLQQSL 709
Query: 585 FPKASSESSY-LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMD 643
S E + ++ L K E + +E++ + E + + L L++++K+ + +
Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL--LEKQMKEKENDLQ 767
Query: 644 ESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVES 703
E F +L+ E ++L E+K+ +++K ++ +++ E+ I + K V
Sbjct: 768 EKFAQLEAENSILKDEKKT-LEDMLK-------IHTPVSQEERLIFLDSIKSKSKDSVWE 819
Query: 704 KHFEDLEFQQLEHESRLDEEKENLTQQL--LREVAEYQRNIVSRKEKISALKKQANHIVQ 761
K E L EE E+L QQ L E E QRN S EK + N+ Q
Sbjct: 820 KEIE-----------ILIEENEDLKQQCIQLNEEIEKQRNTFSFAEK----NFEVNY--Q 862
Query: 762 QAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGF---PVNPNTLK 812
+ Q E +K K++L + +N LE K + + +NP T+K
Sbjct: 863 ELQEEYACLLKVKDDL-----EDSKNKQELEYKSKLKALNEELHLQRINPTTVK 911
Score = 42.7 bits (99), Expect = 0.002
Identities = 59/241 (24%), Positives = 106/241 (43%), Gaps = 46/241 (19%)
Query: 597 ILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALL 656
+L + E + E E ++ET ++ LE Q K + D + + + L+++
Sbjct: 1975 LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK-VRDDLQKQVKALEIDVE-- 2031
Query: 657 DGEQKSETTELMKEK--EILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDL---EF 711
EQ S EL +EK E++D L ++ LEK + + K D ++ +H D+ E
Sbjct: 2032 --EQVSRFIELEQEKNTELMD-LRQQNQALEKQLE-KMRKFLDEQAIDREHERDVFQQEI 2087
Query: 712 QQLE--------------HESRLDE-------EKENLTQQLLREVAEYQRNIVSRKEKIS 750
Q+LE H++R E EK + +LL + QR+I R E+I
Sbjct: 2088 QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIE 2147
Query: 751 ALKKQANHIVQ---------QAQREQDHF----VKEKNNLIMMLQREKENLCNLEKKYSS 797
L+ + + Q Q ++ HF K + +L + LQ E++ + EK+ ++
Sbjct: 2148 KLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITN 2207
Query: 798 L 798
L
Sbjct: 2208 L 2208
Score = 34.7 bits (78), Expect = 0.58
Identities = 71/346 (20%), Positives = 128/346 (36%), Gaps = 77/346 (22%)
Query: 458 RQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKL--QL 515
+Q E LR+ M ++ERQR ED +++ +E+++L QL
Sbjct: 1602 QQATELLRQAHMRQMERQR------------------------EDQEQLQEEIKRLNRQL 1637
Query: 516 SDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASFFTPRSTRNDELL 571
+ S+ E L+S R ++L LA C L SS T N +
Sbjct: 1638 AQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ--TQNGNENQGEV 1695
Query: 572 SDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEEL 631
+ TF + L + PE + E S E A+++ +L L E+
Sbjct: 1696 EE---------QTFKEKE--------LDRKPEDVPPEILSNERYALQKANNRLLKILLEV 1738
Query: 632 KQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELE-KNIVG 690
+ + + + +LD KS+++ + + R AE K+ V
Sbjct: 1739 VKTTAAVEETIGRHV------LGILDRSSKSQSSASL--------IWRSEAEASVKSCVH 1784
Query: 691 EKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLR----------EVAEYQR 740
E+ + S D+ + S++ EE L+Q+L+R E E
Sbjct: 1785 EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELML 1844
Query: 741 NIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKE 786
NI SR + A ++ + + + +H + L+ R+K+
Sbjct: 1845 NISSR---LQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ 1887
Score = 34.7 bits (78), Expect = 0.58
Identities = 44/193 (22%), Positives = 73/193 (37%), Gaps = 27/193 (13%)
Query: 618 EETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHL 677
E T I LN L E D++ L + + L+ + T L+ EKE ++
Sbjct: 2582 ERTNIQNLNQLRE---------DELGSDISALTLRISELESQVVEMHTSLILEKEQVEIA 2632
Query: 678 NRKIAELEKNIVG-------------EKTKDADLLDVESKHFEDLEFQQLEHESRLDEEK 724
+ + E EK ++ EK K DVE F E ES E
Sbjct: 2633 EKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNE-ESGFFNEL 2691
Query: 725 ENLTQQLLR---EVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML 781
E L + + E+A Y+ +E++ + + + + +DH + K L +L
Sbjct: 2692 EALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKL-SIL 2750
Query: 782 QREKENLCNLEKK 794
++E E KK
Sbjct: 2751 EKEDETEVQESKK 2763
Score = 33.1 bits (74), Expect = 1.7
Identities = 101/519 (19%), Positives = 202/519 (38%), Gaps = 63/519 (12%)
Query: 611 SQELAAMEETRIVILNN-----LEELKQKIKDINDQMDESFRELDMECALLDGEQKSE-- 663
S+EL E + ++L+N + E K + I+++M + + ++ D S
Sbjct: 1518 SKELG--EHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMD 1575
Query: 664 -TTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDE 722
+ +LM +E L+ + +++ + E + +LL H +E +Q E + +L E
Sbjct: 1576 ASRQLMLNEEQLEDMRQELVRQYQ----EHQQATELL--RQAHMRQME-RQREDQEQLQE 1628
Query: 723 EKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQ 782
E + L +QL + + N+VS +E++ + +A + A RE+ E N Q
Sbjct: 1629 EIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREK--LCCELRNSSTQTQ 1686
Query: 783 REKENLCNLEK---KYSSLSGGKGFPVNPNTLKEGYISVNEINE------------PCGN 827
EN +E+ K L K V P L ++ + N
Sbjct: 1687 NGNENQGEVEEQTFKEKELD-RKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAV 1745
Query: 828 STNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGL--YLSDTLPR 885
+ D + + A+ + S+ ++ EE + E + Y +PR
Sbjct: 1746 EETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPR 1805
Query: 886 ----------KKTTSSISPHFSSATMGRSITPK-AHLPLGQSNSCGSVLPPSLAAMAKDS 934
++ T S G I P+ L L S+ + + L A+++ S
Sbjct: 1806 NDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETS 1865
Query: 935 ESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSD 994
+ + M E RQK E A+ES H + +A + L+++ S
Sbjct: 1866 SQLEHAKVTQTELMRESFRQKQE-----ATESLKCQEELRERLHE-ESRAREQLAVELSK 1919
Query: 995 SMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEE 1054
+ D + T +I+E ++ + E +R +E+EA+++ ++EE
Sbjct: 1920 AEGVI------DGYADEKTLFERQIQEKTDIIDRLEQE-LLCASNRLQELEAEQQQIQEE 1972
Query: 1055 KRRREILEKRLQEETS--QRQKLIEKEVKIRERQRAQAR 1091
+ ++ ++ E ++Q L E E ++E+ Q +
Sbjct: 1973 RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011
Score = 30.8 bits (68), Expect = 8.4
Identities = 55/260 (21%), Positives = 95/260 (36%), Gaps = 39/260 (15%)
Query: 461 EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 520
E+ + E+E + LE Q+L K + +DV+ + E ++E
Sbjct: 2633 EKNVLEKEKKLLELQKL------LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESG 2686
Query: 521 VFEEALMSPDTRYRCHRKDSLPD-ADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPP 579
F E R +S+ A+LAS ++ + T L DL++
Sbjct: 2687 FFNEL--------EALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRD 2738
Query: 580 PPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQ---KIK 636
+ K LSIL K E +E Q S++ E I + ++ KI
Sbjct: 2739 HLAEAKEK-------LSILEKEDE--TEVQESKKACMFEPLPIKLSKSIASQTDGTLKIS 2789
Query: 637 DINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDA 696
N + ++ L E TE I+ KI ++++ A
Sbjct: 2790 SSNQTPQILVKNAGIQINLQSECSSEEVTE------IISQFTEKIEKMQE------LHAA 2837
Query: 697 DLLDVESKHFEDLEFQQLEH 716
++LD+ES+H + E + EH
Sbjct: 2838 EILDMESRHISETETLKREH 2857
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 57.0 bits (136), Expect = 1e-07
Identities = 156/771 (20%), Positives = 309/771 (40%), Gaps = 129/771 (16%)
Query: 437 RERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLST 496
R ++ +S++ +D L D + + +L +++ +L++Q LE L T+ D+ +
Sbjct: 510 RNVENEVSTL--KDQLEDLKKVSQNSQLANEKLSQLQKQ-LEEANDLLR--TESDTAVRL 564
Query: 497 GTTVEDVQKINKELEKL--QLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQ 554
+ ++ K +LE L +L + + E + D Y ++ ++ +A+ G
Sbjct: 565 RKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDY--YQLQAILEAERRDRG---- 618
Query: 555 SSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQEL 614
+ E++ DL + E +L + EG E + +Q++
Sbjct: 619 -----------HDSEMIGDL-------QARITSLQEEVKHLKHNLEKVEG--ERKEAQDM 658
Query: 615 AAMEETRIVILNNLE-ELKQKIKDINDQMDESFRELDMECA-LLDGEQKSETTELMKEKE 672
E NNLE +L K+K + ++++ E + A L D Q E + + E
Sbjct: 659 LNHSEKE---KNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCE 715
Query: 673 ILDHLN--RKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEH----ESRLDEEKEN 726
+ L R+ E +N V + K +LDV+ K + Q+LEH + R+++E +N
Sbjct: 716 MEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQ----QKLEHLTGNKERMEDEVKN 771
Query: 727 LTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKE 786
LT QL +E +R ++ + K A + +++ +++ + + E L+ +
Sbjct: 772 LTLQLEQE--SNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLL------EF 823
Query: 787 NLCNLEKKYSSLSGGKGFPVNPNTLKEGYIS------VNEINEPC--GNSTNLSPSTQFP 838
L L K+Y + G+ + E Y S V E+ E N NL +
Sbjct: 824 ELAQLTKQYRG-NEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQ 882
Query: 839 ADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSS 898
+ + +AT+ A ++ +S++ R L E + Y T KK S
Sbjct: 883 NEKETLATQLDLA--ETKAESEQLARGLLEEQ-------YFELTQESKKAAS-------- 925
Query: 899 ATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEF 958
+ IT K H S L + + + KD E R +++++E ++ E
Sbjct: 926 -RNRQEITDKDHTV--------SRLEEANSMLTKDIEILRR----ENEELTEKMKKAEEE 972
Query: 959 YNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIAR 1018
Y E L + AF+ ++++ +++T + + +A
Sbjct: 973 YKLEKEEEISNLKA-----------AFEK-NINTERTLKTQ------------AVNKLAE 1008
Query: 1019 IEEMERLLKQAHAEKTRLLESREREMEAKKRALE---EEKRRREILEKRLQEETSQRQKL 1075
I M R + +K + R++E E +K LE E ++ +++ K +E + +L
Sbjct: 1009 I--MNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQL 1066
Query: 1076 IEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFL- 1134
+E+ E Q A + +R + DL A ++ E G+L
Sbjct: 1067 VEECAHRNELQMQLASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLS 1126
Query: 1135 IKMGGKIKT--WKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYY 1183
+ G IK WKK++ V K F Y D+ + + I+++++
Sbjct: 1127 VPNRGNIKRYGWKKQYVVVSSKKILF--YNDEQDKEQSNPSMVLDIDKLFH 1175
Score = 43.9 bits (102), Expect = 0.001
Identities = 120/630 (19%), Positives = 247/630 (39%), Gaps = 114/630 (18%)
Query: 607 EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQK----S 662
+E + + +EE + +E++QK + N ++D+ +ELD E G Q+ S
Sbjct: 425 QESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEE-----GNQRRNLES 479
Query: 663 ETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLE-FQQLEHESRLD 721
+++ KEK +L H +I E ++ E K ++ + S + LE +++ S+L
Sbjct: 480 TVSQIEKEKMLLQH---RINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLA 536
Query: 722 EEKENLTQQLLREVAEYQR-----------------NIVSRKEKISALKKQANHIVQ--Q 762
EK + Q+ L E + R +S+ E ++ ++ N I++ +
Sbjct: 537 NEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSK 596
Query: 763 AQREQDHF-------------------VKEKNNLIMMLQREKENL-CNLEKKYSSLSGGK 802
+Q ++D++ + + I LQ E ++L NLEK +
Sbjct: 597 SQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQ 656
Query: 803 GFPVNPNTLKEGYISVN--------------EINEPCGNSTNLSPSTQFPADADAVATEP 848
+N + ++ + ++ E+NE L+ Q +A +VA
Sbjct: 657 DM-LNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCE 715
Query: 849 ATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPK 908
L + +++E E R Q ++ + D + K++ + +
Sbjct: 716 MEKKLKEEREARE---KAENRVVQIEKQCSMLD-VDLKQSQQKLEHLTGNKERMEDEVKN 771
Query: 909 AHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNV 968
L L Q ++ +L L A ++++ + L Q+++ K A +
Sbjct: 772 LTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQ 831
Query: 969 YLNS----FHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMER 1024
Y + D +Q F TL ++ + I + N+ +I+E++
Sbjct: 832 YRGNEGQMRELQDQLEAEQYFSTLYKTQVKELK--------EEIEEKNRENLKKIQELQN 883
Query: 1025 LLKQAHAEKTRLLESREREMEAKKRALEEE-------------KRRREILEK-----RLQ 1066
K+ A + L E++ + + LEE+ + R+EI +K RL+
Sbjct: 884 -EKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLE 942
Query: 1067 EETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSI- 1125
E S ++ K+++I R+ + LT + +E++ L E + N+ + +I
Sbjct: 943 EANS----MLTKDIEILRRENEE---LTEKMKKAEEEYKLEKEEEIS--NLKAAFEKNIN 993
Query: 1126 TEKTCRGFLIKMGGKIKTWKKRWFVFDRNK 1155
TE+T + + +I K F DR K
Sbjct: 994 TERTLKTQAVNKLAEIMNRKD--FKIDRKK 1021
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 56.2 bits (134), Expect = 2e-07
Identities = 113/552 (20%), Positives = 211/552 (38%), Gaps = 75/552 (13%)
Query: 288 RATENQLTPL-SLPPRNSLGNSKRTKL------GEKDLPHSVIDNDNYLNFSSLSSGALP 340
+ATE +L L +L +S G S+ KL EK + H I+ N S + ++
Sbjct: 721 KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK----NAESSKASSI- 775
Query: 341 YKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGES 400
T +G + L S K L + F +AS + S+
Sbjct: 776 --TRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE-TV 832
Query: 401 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERK-----------------SSI 443
+++ F+ S +DLE LR+ + RE+ + I
Sbjct: 833 NKLHQKEEQFNMLS-----SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEI 887
Query: 444 SSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDV 503
+SG D+ + E RL+E+++E L+ + TK + E+
Sbjct: 888 MKMSG-DNSSQLTKMNDELRLKERDVEELQ-----------LKLTKAN---------ENA 926
Query: 504 QKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASF 559
+ K +E + + E+S E A + + RK S + + + C L
Sbjct: 927 SFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERA 986
Query: 560 FTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEE 619
+ T+++E+L +L +T A E+S +L + E + +++ E+
Sbjct: 987 TSETKTKHEEILQNLQKTLLDTEDKLKGAREENS--GLLQELEELRKQADKAKAAQTAED 1044
Query: 620 TRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNR 679
++ +E + + + D + + L E L EL K KE+L N+
Sbjct: 1045 AMQIMEQMTKEKTETLASLEDTKQTNAK-LQNELDTLKENNLKNVEELNKSKELLTVENQ 1103
Query: 680 KIAELEKNI------VGEKTKDADLLDVES-KHFEDL--EFQQLEHESRLDEEKENLTQQ 730
K+ E K I +K++ L E+ K E+L ++ +L+EE+ L Q
Sbjct: 1104 KMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQ 1163
Query: 731 LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCN 790
LL + I E+ ++L+K + I E+D +++ N + +L+ E + +
Sbjct: 1164 LLEMKKRESKFIKDADEEKASLQKSIS-ITSALLTEKDAELEKLRNEVTVLRGENASAKS 1222
Query: 791 LEKKYSSLSGGK 802
L +L K
Sbjct: 1223 LHSVVQTLESDK 1234
Score = 50.4 bits (119), Expect = 1e-05
Identities = 202/1068 (18%), Positives = 377/1068 (35%), Gaps = 183/1068 (17%)
Query: 91 QPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSGYPL 150
Q PA R+ SPL TS S S S T NIP KP P P
Sbjct: 138 QTTPASRATSPLCTSTASMVS----------SSPSTPSNIPQKPSQPAAKE-------PS 180
Query: 151 GRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEG----RKASGSLLAM 206
+ T SE LSE K K D V G G +
Sbjct: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240
Query: 207 WNGSSLSDA-GPPPISRSGAASMPSSPK--------QARKMSIQDSLALQPKLTRHKELA 257
W G L + G + +G PK + K+ + + K + +
Sbjct: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM 300
Query: 258 SENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKD 317
+ R S+SSLS M + + S+ S P R L ++ K
Sbjct: 301 ATTSASLKRSPSASSLSSMSSVASSVS-------------SRPSRTGLLTETSSRYARK- 346
Query: 318 LPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCA 377
SG + + E ++ L A + R + +TS
Sbjct: 347 -----------------ISGTTALQEALKEKQQHIEQLL---AERDLERAEVAKATSHVG 386
Query: 378 SDDFDQASYVGTNPSHSL-LAGESDRVFATRRNFSCGSVEFDEADLESLRQASG----TP 432
+ + A + H L L + D++ VE E R+
Sbjct: 387 EIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVE 446
Query: 433 QPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 492
+ ++ + ++++S + +M+ +++ LR QE+ L R+RLE+ KP
Sbjct: 447 EESITKGDLEVATVSEKSRIMEL---EKDLALRVQEVAEL-RRRLES--------NKPAG 494
Query: 493 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD--TRYRCHRKDSLPDADLASCG 550
+ ++ +Q+I+ EKL+++ + E + R H+K+
Sbjct: 495 DVDMSLSL--LQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEI---------- 542
Query: 551 SLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQR 610
+ T + ++ +E L S A+ E+S + L K+ +
Sbjct: 543 ----KALYTATEKLSKENESLK----------SKLEHANKENSDVIALWKSKLETAIASH 588
Query: 611 SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKE 670
Q AMEE ++ L + ++ Q+++ + E L +Q SE KE
Sbjct: 589 QQ---AMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKE 645
Query: 671 KEILDHLNRKIAELEKNIVG------EKTKDADLLDVES------------KHFEDLEFQ 712
E L K+ + ++N + +K +D L+++E K E L+ +
Sbjct: 646 MEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAK 705
Query: 713 QLEHESRLDEEKENL--TQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHF 770
E +D L T++ L ++ ++ K ++ L++Q ++ A+++ H
Sbjct: 706 CNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQ----LEAAEKQIKHL 761
Query: 771 VKEKN-------NLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINE 823
EKN ++ LQ + L NL++ S +S V KE I + E
Sbjct: 762 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVS-----QVKETLEKELQILKEKFAE 816
Query: 824 PCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEH-------FRSLEERKKQ---H 873
+ ++ S Q + E + + + +E+ FR +ER++Q
Sbjct: 817 ASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 876
Query: 874 KEGLY--LSDTLPRKKTTSS-ISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAM 930
KE L +++ + SS ++ + + L L ++N S L S+ M
Sbjct: 877 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 936
Query: 931 AKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSL 990
+E + Q+ ++ H ++ + R S+ + + H K + ++ +
Sbjct: 937 TVKAEQ-------SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR-YERATS 988
Query: 991 DSSDSMETSISAC------SPDNISSASTSNIARIEEMERLLKQAHAEKT--------RL 1036
++ E + + D + A N ++E+E L KQA K ++
Sbjct: 989 ETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQI 1048
Query: 1037 LESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRE 1084
+E +E +LE+ K+ L+ L K +E+ K +E
Sbjct: 1049 MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKE 1096
Score = 39.3 bits (90), Expect = 0.023
Identities = 112/563 (19%), Positives = 224/563 (39%), Gaps = 99/563 (17%)
Query: 605 ISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDG----EQ 660
+SE+ R EL E+ + + + EL+++++ ++ ++DM +LL ++
Sbjct: 460 VSEKSRIMEL---EKDLALRVQEVAELRRRLES-----NKPAGDVDMSLSLLQEISSLQE 511
Query: 661 KSETTELMKEKEIL---DHLNRKIAELEKNIVGEKTKDADL----------LDVESKHFE 707
K E T ++EI +H + +K I T L L+ +K
Sbjct: 512 KLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENS 571
Query: 708 D--------LEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI 759
D LE H+ ++E K + ++ L E AE+ K +I ++ H
Sbjct: 572 DVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEF----AELKTQIEKMRLDYQHE 627
Query: 760 VQQAQREQDH----FVKEKNNL---IMMLQREKENLCNLEKKYSSLSGGKGFPV-----N 807
++ Q +QD KE L +M + +EKEN +LE S L + +
Sbjct: 628 IENLQNQQDSERAAHAKEMEALRAKLMKVIKEKEN--SLEAIRSKLDKAEDQHLVEMEDT 685
Query: 808 PNTLKEGYISVNEIN---EPCGNSTNLSPS--TQFPADADAVATEPATAVLASQPQS--K 860
N L+E I V E+ C T + + +Q A + + A +S+ +S K
Sbjct: 686 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMK 745
Query: 861 EHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSIT-PKAHLPLGQSNSC 919
+ + LE +KQ K K SS + + GR + L + +
Sbjct: 746 KLRQQLEAAEKQIKH------LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQV 799
Query: 920 GSVLPPSLAAM----AKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHY 975
L L + A+ SE ++ + +++ H QK E +N +S+ +
Sbjct: 800 KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLAD 858
Query: 976 PDHSY--KDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEK 1033
+ + KD+ + L + + + +E I+ +S ++S + ++ + RL
Sbjct: 859 MEAKFREKDEREEQL-IKAKEKLENDIAEIM--KMSGDNSSQLTKMNDELRL-------- 907
Query: 1034 TRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPL 1093
+ER++E + L + L+K +++ T + ++ ++ K E ++ +
Sbjct: 908 ------KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE---- 957
Query: 1094 TRYLPVRKEDFDLRSHVETAGHN 1116
+ ++ DL +ET+ HN
Sbjct: 958 -----LERKLSDLEKKMETS-HN 974
Score = 34.3 bits (77), Expect = 0.76
Identities = 27/104 (25%), Positives = 52/104 (50%), Gaps = 24/104 (23%)
Query: 1012 STSNIARIEEMERLLKQAHAEKTRLLESR-----------EREMEAKKRALEEEKRRREI 1060
+TS++ IE+ L + H + LE++ +RE LEEEKR+ E
Sbjct: 381 ATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVED 440
Query: 1061 LEKRLQEET-----------SQRQKL--IEKEVKIRERQRAQAR 1091
L+ R++EE+ S++ ++ +EK++ +R ++ A+ R
Sbjct: 441 LQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELR 484
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 56.2 bits (134), Expect = 2e-07
Identities = 113/552 (20%), Positives = 211/552 (38%), Gaps = 75/552 (13%)
Query: 288 RATENQLTPL-SLPPRNSLGNSKRTKL------GEKDLPHSVIDNDNYLNFSSLSSGALP 340
+ATE +L L +L +S G S+ KL EK + H I+ N S + ++
Sbjct: 756 KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK----NAESSKASSI- 810
Query: 341 YKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGES 400
T +G + L S K L + F +AS + S+
Sbjct: 811 --TRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE-TV 867
Query: 401 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERK-----------------SSI 443
+++ F+ S +DLE LR+ + RE+ + I
Sbjct: 868 NKLHQKEEQFNMLS-----SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEI 922
Query: 444 SSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDV 503
+SG D+ + E RL+E+++E L+ + TK + E+
Sbjct: 923 MKMSG-DNSSQLTKMNDELRLKERDVEELQ-----------LKLTKAN---------ENA 961
Query: 504 QKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASF 559
+ K +E + + E+S E A + + RK S + + + C L
Sbjct: 962 SFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERA 1021
Query: 560 FTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEE 619
+ T+++E+L +L +T A E+S +L + E + +++ E+
Sbjct: 1022 TSETKTKHEEILQNLQKTLLDTEDKLKGAREENS--GLLQELEELRKQADKAKAAQTAED 1079
Query: 620 TRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNR 679
++ +E + + + D + + L E L EL K KE+L N+
Sbjct: 1080 AMQIMEQMTKEKTETLASLEDTKQTNAK-LQNELDTLKENNLKNVEELNKSKELLTVENQ 1138
Query: 680 KIAELEKNI------VGEKTKDADLLDVES-KHFEDL--EFQQLEHESRLDEEKENLTQQ 730
K+ E K I +K++ L E+ K E+L ++ +L+EE+ L Q
Sbjct: 1139 KMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQ 1198
Query: 731 LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCN 790
LL + I E+ ++L+K + I E+D +++ N + +L+ E + +
Sbjct: 1199 LLEMKKRESKFIKDADEEKASLQKSIS-ITSALLTEKDAELEKLRNEVTVLRGENASAKS 1257
Query: 791 LEKKYSSLSGGK 802
L +L K
Sbjct: 1258 LHSVVQTLESDK 1269
Score = 53.5 bits (127), Expect = 1e-06
Identities = 207/1090 (18%), Positives = 379/1090 (34%), Gaps = 192/1090 (17%)
Query: 91 QPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSGYPL 150
Q PA R+ SPL TS S S S T NIP KP P P
Sbjct: 138 QTTPASRATSPLCTSTASMVS----------SSPSTPSNIPQKPSQPAAKE-------PS 180
Query: 151 GRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEG----RKASGSLLAM 206
+ T SE LSE K K D V G G +
Sbjct: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240
Query: 207 WNGSSLSDA-GPPPISRSGAASMPSSPK--------QARKMSIQDSLALQPKLTRHKELA 257
W G L + G + +G PK + K+ + + K + +
Sbjct: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM 300
Query: 258 SENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKD 317
+ R S+SSLS M + + S+ S P R L ++ K
Sbjct: 301 ATTSASLKRSPSASSLSSMSSVASSVS-------------SRPSRTGLLTETSSRYARK- 346
Query: 318 LPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCA 377
SG + + E ++ L A
Sbjct: 347 -----------------ISGTTALQEALKEKQQHIEQLL--------------------A 369
Query: 378 SDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALR 437
D ++A V SH GE ++ A R+ V EA ++ LR + A R
Sbjct: 370 ERDLERAE-VAKATSH---VGEIEQELALARDGHDQHVLELEAKMDQLRTMV---EAADR 422
Query: 438 ERKSSISSISG-RDDLMDYHRRQREERLREQEME---RLERQRLETI-LSLCAEYTKPDS 492
E+ ++ + + + D R EE + + ++E +LE R++ + SL E TK D
Sbjct: 423 EKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKAD- 481
Query: 493 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
+L V ++++ ++L + ++ + + R ++ D L+ +
Sbjct: 482 KLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEI 541
Query: 553 SQSSASFFTPRSTRNDELLS------------------------DLTRTPPPPSSTFPKA 588
S R+ E+ S L++ S A
Sbjct: 542 SSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHA 601
Query: 589 SSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRE 648
+ E+S + L K+ + Q AMEE ++ L + ++ Q+++ +
Sbjct: 602 NKENSDVIALWKSKLETAIASHQQ---AMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 658
Query: 649 LDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVG------EKTKDADLLDVE 702
E L +Q SE KE E L K+ + ++N + +K +D L+++E
Sbjct: 659 YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME 718
Query: 703 S------------KHFEDLEFQQLEHESRLDEEKENL--TQQLLREVAEYQRNIVSRKEK 748
K E L+ + E +D L T++ L ++ ++ K +
Sbjct: 719 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 778
Query: 749 ISALKKQANHIVQQAQREQDHFVKEKN-------NLIMMLQREKENLCNLEKKYSSLSGG 801
+ L++Q ++ A+++ H EKN ++ LQ + L NL++ S +S
Sbjct: 779 MKKLRQQ----LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVS-- 832
Query: 802 KGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKE 861
V KE I + E + ++ S Q + E + + + +E
Sbjct: 833 ---QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE 889
Query: 862 H-------FRSLEERKKQ---HKEGLY--LSDTLPRKKTTSS-ISPHFSSATMGRSITPK 908
+ FR +ER++Q KE L +++ + SS ++ + +
Sbjct: 890 NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 949
Query: 909 AHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNV 968
L L ++N S L S+ M +E + Q+ ++ H ++ + R S+
Sbjct: 950 LQLKLTKANENASFLQKSIEDMTVKAEQ-------SQQEAAKKHEEEKKELERKLSDLEK 1002
Query: 969 YLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISAC------SPDNISSASTSNIARIEEM 1022
+ + H K + ++ + ++ E + + D + A N ++E+
Sbjct: 1003 KMETSHNQCQELKAR-YERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQEL 1061
Query: 1023 ERLLKQAHAEKT--------RLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1074
E L KQA K +++E +E +LE+ K+ L+ L K
Sbjct: 1062 EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK 1121
Query: 1075 LIEKEVKIRE 1084
+E+ K +E
Sbjct: 1122 NVEELNKSKE 1131
Score = 42.4 bits (98), Expect = 0.003
Identities = 141/725 (19%), Positives = 275/725 (37%), Gaps = 94/725 (12%)
Query: 426 RQASGTP--QPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLERQRLETIL 481
R+ SGT Q AL+E++ I + DL + + E QE+ + +L
Sbjct: 345 RKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVL 404
Query: 482 SLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 541
L A+ +L T D +K+ EL QL +E+ E D ++R ++S+
Sbjct: 405 ELEAKM----DQLRTMVEAADREKV--ELLN-QLEEEKRKVE------DLQFRVE-EESI 450
Query: 542 PDADLASCGSLSQSSASFFTP----RSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSI 597
DL + L + T+ D+L +L T S + L++
Sbjct: 451 TKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLAL 510
Query: 598 LPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLD 657
+ + S + A + + +L + L++K++ L +
Sbjct: 511 RVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGARE 570
Query: 658 GEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHE 717
+ E L E L N + ++ E + DV + LE H+
Sbjct: 571 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENS------DVIALWKSKLETAIASHQ 624
Query: 718 SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDH----FVKE 773
++E K + ++ L E AE+ K +I ++ H ++ Q +QD KE
Sbjct: 625 QAMEELKVSFSKGLGTETAEF----AELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKE 680
Query: 774 KNNL---IMMLQREKENLCNLEKKYSSLSGGKGFPV-----NPNTLKEGYISVNEIN--- 822
L +M + +EKEN +LE S L + + N L+E I V E+
Sbjct: 681 MEALRAKLMKVIKEKEN--SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 738
Query: 823 EPCGNSTNLSPS--TQFPADADAVATEPATAVLASQPQS--KEHFRSLEERKKQHKEGLY 878
C T + + +Q A + + A +S+ +S K+ + LE +KQ K
Sbjct: 739 AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKH--- 795
Query: 879 LSDTLPRKKTTSSISPHFSSATMGRSIT-PKAHLPLGQSNSCGSVLPPSLAAM----AKD 933
K SS + + GR + L + + L L + A+
Sbjct: 796 ---LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 852
Query: 934 SESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSY--KDQAFDTLSLD 991
SE ++ + +++ H QK E +N +S+ + + + KD+ + L +
Sbjct: 853 SEEAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQL-IK 910
Query: 992 SSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRAL 1051
+ + +E I+ +S ++S + ++ + RL +ER++E + L
Sbjct: 911 AKEKLENDIAEIM--KMSGDNSSQLTKMNDELRL--------------KERDVEELQLKL 954
Query: 1052 EEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVE 1111
+ L+K +++ T + ++ ++ K E ++ + + ++ DL +E
Sbjct: 955 TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE---------LERKLSDLEKKME 1005
Query: 1112 TAGHN 1116
T+ HN
Sbjct: 1006 TS-HN 1009
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 55.8 bits (133), Expect = 2e-07
Identities = 133/695 (19%), Positives = 280/695 (40%), Gaps = 112/695 (16%)
Query: 451 DLMDYHRRQR--EERLREQEMERLERQRLETILS------------LCAEYTKPDSRLST 496
+LM+ H + RLR E++R+E Q +L L A + ++ S
Sbjct: 1314 ELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASA 1373
Query: 497 GTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSS 556
+E+ + + KL+ + ES R R + +A +L ++
Sbjct: 1374 AGILEEDLRTARSALKLKNEEVES----------ERERAQALQEQGELKVAQGKALQENL 1423
Query: 557 ASFFTPRSTRNDEL------LSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQR 610
A + R +E+ + +L + KA+ E L + + E ++++
Sbjct: 1424 ALLTQTLAEREEEVETLRGQIQELEK-----QREMQKAALELLSLDLKKRNQEVDLQQEQ 1478
Query: 611 SQELAAMEETRIVILNNLEELKQKIKDINDQMD---ESFRELDMECALLDGEQKSETTEL 667
QEL E+ R V LE L +++ ++ E REL+ + + + EL
Sbjct: 1479 IQEL---EKCRSV----LEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531
Query: 668 MKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQL---EHESRLDEEK 724
K+ ++++ ++ +L+K +V T + L++E H + +E QQ E E + + ++
Sbjct: 1532 EKKDQMIESQRGQVQDLKKQLV---TLECLALELEENHHK-MECQQKLIKELEGQRETQR 1587
Query: 725 ENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE 784
LT L ++ E + + ++ +I L+ + + ++ Q E+D VK + I LQR+
Sbjct: 1588 VALTHLTL-DLEERSQELQAQSSQIHDLESHSTVLARELQ-ERDQEVKSQREQIEELQRQ 1645
Query: 785 KENLC-NLEKKYSSL------------SGGKGFPVNPNTLKEGYISVNEINEPCGNSTNL 831
KE+L +LE++ L + + L++ +S+ E L
Sbjct: 1646 KEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQL 1705
Query: 832 ----SPSTQFPADADAVATEPATAVLASQPQ----SKEHFRSLEERKKQHKEGLYLSDTL 883
+ + P+ A + E +L + + +EH L+E K Q ++ L L
Sbjct: 1706 MQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQL---QGL 1762
Query: 884 PRKKTTSSI---SPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRML 940
RK +S+ + + + + S S L + A+A+ + L
Sbjct: 1763 HRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEAL 1822
Query: 941 RGYNHQQMSEGH----RQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSM 996
+ QQ ++G ++K++ ++++ L H +K+QA L+ ++
Sbjct: 1823 Q--QEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQA---RRLEEELAV 1877
Query: 997 ETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKR 1056
E R++ +E +L AE +E+ + A ++ E+ +
Sbjct: 1878 EG------------------RRVQALEEVLGDLRAES----REQEKALLALQQQCAEQAQ 1915
Query: 1057 RREILEKRLQEETSQRQKLIEKEVKIRERQRAQAR 1091
E+ + LQ+ Q Q ++++ + E RA+++
Sbjct: 1916 EHEVETRALQDSWLQAQAVLKERDQELEALRAESQ 1950
Score = 47.4 bits (111), Expect = 9e-05
Identities = 160/762 (20%), Positives = 295/762 (38%), Gaps = 129/762 (16%)
Query: 407 RRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS-------SISGRDDLMDYHRRQ 459
+R ++E DL+ Q Q ++E + S ++ R+ + R Q
Sbjct: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509
Query: 460 REERLREQEMER--LERQRLETILSLCAEYTKPDSRL-STGTTVEDVQKINKELEKLQLS 516
E +++E +R LE Q LE K D + S V+D++K LE L L
Sbjct: 1510 IRELEKDRETQRNVLEHQLLEL--------EKKDQMIESQRGQVQDLKKQLVTLECLALE 1561
Query: 517 DEESVF----EEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLS 572
EE+ ++ L+ R ++ +L L L + S +S++ +L S
Sbjct: 1562 LEENHHKMECQQKLIKELEGQRETQRVALTHLTL----DLEERSQEL-QAQSSQIHDLES 1616
Query: 573 DLTRTPPPPSSTFPKASSESSYLSILPKTPEGISE--EQRSQELAAMEETRIVILNNLEE 630
T + S+ + L + E +++ E+R QEL +E RI +L +
Sbjct: 1617 HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKE-RIQVLEDQRT 1675
Query: 631 LKQKIKDIN-DQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIV 689
+ KI + + +Q+ S RE E Q+ E +E + R E K I+
Sbjct: 1676 RQTKILEEDLEQIKLSLRERGRELTT----QRQLMQERAEEGKGPSKAQRGSLEHMKLIL 1731
Query: 690 GEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL---REVAEYQRNIVSRK 746
+K K+ + Q EH L E K+ L QQL R+V E + R+
Sbjct: 1732 RDKEKEVEC--------------QQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQRE 1777
Query: 747 EKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPV 806
++I L++Q +Q + ++ + + L + + L L+++ G +
Sbjct: 1778 QEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQE---- 1833
Query: 807 NPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ----PQSKEH 862
+KE ADA A E A L + KE
Sbjct: 1834 --ERVKE------------------------KADALQGALEQAHMTLKERHGELQDHKEQ 1867
Query: 863 FRSLEE------RKKQHKE---GLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPL 913
R LEE R+ Q E G +++ ++K ++ + + +A
Sbjct: 1868 ARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDS 1927
Query: 914 G-QSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNS 972
Q+ + L A+ +S+S R HQ+ E R ++E +++ L
Sbjct: 1928 WLQAQAVLKERDQELEALRAESQSSR------HQE--EAARARAEALQEALGKAHAALQG 1979
Query: 973 FHYPDHSYKDQAFDTLSLDSSDS-METSISACSPDNISSASTSNIA---------RIEEM 1022
+ +QA + SL++S + ++ S+ AC + I R +E
Sbjct: 1980 ---KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQED 2036
Query: 1023 ERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK- 1081
+ L+QA A++ L R + +++ LE+ +R + E +QE+ + Q+ E+E++
Sbjct: 2037 VQQLQQALAQRDEEL----RHQQEREQLLEKSLAQR-VQENMIQEKQNLGQEREEEEIRG 2091
Query: 1082 ----IRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDT 1119
+RE Q A+ L +R + R+++E H+ T
Sbjct: 2092 LHQSVRELQLTLAQKEQEILELR--ETQQRNNLEALPHSHKT 2131
Score = 46.2 bits (108), Expect = 2e-04
Identities = 147/723 (20%), Positives = 277/723 (38%), Gaps = 126/723 (17%)
Query: 422 LESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQR---LE 478
LESL + + L+E+++ + +I + + R Q E L + ++E E++R LE
Sbjct: 877 LESLEREKMELEMRLKEQQTEMEAIQAQ---REEERTQAESALCQMQLET-EKERVSLLE 932
Query: 479 TILSLCAEYTKPDSRLSTGTTVEDVQKINKE----LEKLQLSDEESVFEEALMSPDTRYR 534
T+L E +L VQK+ ++ + + QL + + +EA R
Sbjct: 933 TLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA-------R 985
Query: 535 CHRKDSLPDADLASCGSLSQSSASFFTPR---STRNDELLSDLTRTPPPPSSTFPKASSE 591
HR D +L + S+S + + ++L S L + +
Sbjct: 986 QHRDD---------LAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEK 1036
Query: 592 SSYLSILPKTPEGISEEQRSQELAAME-ETRIVILNNLEELKQK-IKDINDQMDESFREL 649
+ + + E+ S L+ ME E R+++L + ++Q+ + + M E+
Sbjct: 1037 LRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEA---- 1092
Query: 650 DMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDL 709
GEQK EL + E+L K K+AD L E++ E+L
Sbjct: 1093 -------QGEQK----ELSAQMELLRQ-------------EVKEKEADFLAQEAQLLEEL 1128
Query: 710 EFQQLEHE---SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 766
E + + + L ++ Q LR R+ S+ E ++A ++ N QAQ
Sbjct: 1129 EASHITEQQLRASLWAQEAKAAQLQLR-----LRSTESQLEALAAEQQPGNQAQAQAQLA 1183
Query: 767 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 826
+L LQ+ ++C + S GG P SV +
Sbjct: 1184 ---------SLYSALQQALGSVCESRPELS--GGGDSAP-----------SVWGLEPDQN 1221
Query: 827 NSTNLSPS----TQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDT 882
+ +L T A+A A A L Q+++ R ++ ++ L+DT
Sbjct: 1222 GARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEER-----LTDT 1276
Query: 883 LPRKKTTSSISPHFSSATMGRSITPKAHLPL---GQSNSCGSVLPPSLAAMAKDSESRRM 939
K H + R ++ G+ NS S L MA S R+
Sbjct: 1277 EAEKSQV-----HTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMA--SLQSRL 1329
Query: 940 LRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETS 999
R + ++G R+ + A++ N+ H + +A + + + + T+
Sbjct: 1330 RRAELQRMEAQGERELLQ-----AAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTA 1384
Query: 1000 ISACSPDNISSASTSNIARIEEMERLLKQAHAEK--------TRLLESREREMEAKKRAL 1051
SA N S A+ + + LK A + T+ L RE E+E + +
Sbjct: 1385 RSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQI 1444
Query: 1052 EEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQ---RAQARPLTRYLPVRKEDFDLRS 1108
+E +++RE ++K E S K +EV +++ Q + R + +LP+ ++ + +
Sbjct: 1445 QELEKQRE-MQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKL 1503
Query: 1109 HVE 1111
V+
Sbjct: 1504 TVQ 1506
Score = 45.4 bits (106), Expect = 3e-04
Identities = 90/529 (17%), Positives = 214/529 (40%), Gaps = 57/529 (10%)
Query: 607 EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTE 666
+++ ++ L ++E ++ + L+E + +++ I Q +E + + + E + E
Sbjct: 870 QQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVS 929
Query: 667 LMK-----EKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLD 721
L++ +KE+ D ++++ L +++ +K K+ + + ++ + + E +
Sbjct: 930 LLETLLQTQKELAD-ASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHR 988
Query: 722 EEKENLTQQ---LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLI 778
++ L ++ LL++ + Q+ + K ++ A + + +V+Q +E+ +E N +
Sbjct: 989 DDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA-QDDSQRLVEQEVQEKLRETQEYNRIQ 1047
Query: 779 MMLQREKEN--LCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQ 836
L+REK + L +EK+ L + + L ++ E G LS +
Sbjct: 1048 KELEREKASLTLSLMEKEQRLLVLQEADSIRQQELS---ALRQDMQEAQGEQKELSAQME 1104
Query: 837 FPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDT------LPRKKTTS 890
E LA + Q E + ++Q + L+ + L + T S
Sbjct: 1105 LLRQE---VKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTES 1161
Query: 891 SISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSE 950
+ + G +A L S S L +L ++ ESR L G S
Sbjct: 1162 QLEALAAEQQPGNQAQAQAQLA-----SLYSALQQALGSVC---ESRPELSGGGDSAPSV 1213
Query: 951 GHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISS 1010
+ + R+ + L + S++++ +++ D +
Sbjct: 1214 WGLEPDQNGARSLFKRGPLLTAL------------------SAEAVASALHKLHQDLWKT 1255
Query: 1011 ASTSNIAR--IEEMERLLKQAHAEKTRL---LESREREMEAKKRALEEEKRRREILEKRL 1065
T ++ R ++++E L AEK+++ L+ +R++ + + + ++ LE L
Sbjct: 1256 QQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESEL 1315
Query: 1066 QEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR-SHVETA 1113
E + ++ ++ E QR +A+ L KE+ + H++ A
Sbjct: 1316 M-ELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAA 1363
Score = 43.1 bits (100), Expect = 0.002
Identities = 127/703 (18%), Positives = 262/703 (37%), Gaps = 74/703 (10%)
Query: 444 SSISGRDDLMDYHRRQREERLRE-QEMERLERQRLETILSLCAEYTKPDSRLSTGTTVED 502
S + +DD ++ +E+LRE QE R++++ SL + + RL +
Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADS 1076
Query: 503 VQKINKELEKLQLSDEESVFEEALMSPDTRY-RCHRKDSLPDADLASCGSLSQSSASFFT 561
+++ +EL L+ +E+ E+ +S R K+ D L + AS T
Sbjct: 1077 IRQ--QELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHIT 1134
Query: 562 PRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETR 621
+ R + L + + S S L L + ++ Q +LA++
Sbjct: 1135 EQQLR-----ASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSAL 1189
Query: 622 IVILNNLEELKQKIKDINDQMDESF---------RELDMECALLDGEQKSETT------- 665
L ++ E + ++ D + R L LL
Sbjct: 1190 QQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249
Query: 666 -ELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQ--QLEHESRLDE 722
+L K ++ D L ++ +LE+ + + + + + +DL+ Q Q + E E
Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQV----HTELQDLQRQLSQNQEEKSKWE 1305
Query: 723 EKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQ 782
K+N + L E+ E ++ SR + + +A Q +RE KE + Q
Sbjct: 1306 GKQNSLESELMELHETMASLQSRLRRAELQRMEA-----QGERELLQAAKEN----LTAQ 1356
Query: 783 REKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPAD-- 840
E +E + + + G + L+ ++ NE + + + Q +
Sbjct: 1357 VEHLQAAVVEARAQASAAG----ILEEDLRTARSALKLKNEEVESERERAQALQEQGELK 1412
Query: 841 -ADAVATEPATAVLASQPQSKEH--------FRSLEERKKQHKEGLYLS--DTLPRKKTT 889
A A + A+L +E + LE++++ K L L D R +
Sbjct: 1413 VAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEV 1472
Query: 890 SSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRR------MLRGY 943
RS+ + + + +V + + KD E++R +L
Sbjct: 1473 DLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELE 1532
Query: 944 NHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISAC 1003
QM E Q+ + + + + ++ +K + L + ET A
Sbjct: 1533 KKDQMIES--QRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVAL 1590
Query: 1004 SPDNISSASTSNIARIEEMERLLKQAHAEK-TRLLESREREMEAKKRALEEEKRRREILE 1062
+ + S + + + ++H+ R L+ R++E+++++ +EE +R++E L
Sbjct: 1591 THLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLT 1650
Query: 1063 KRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFD 1105
+ L E Q L ++ +++ E QR TR + +ED +
Sbjct: 1651 QDL-ERRDQELMLQKERIQVLEDQR------TRQTKILEEDLE 1686
Score = 37.4 bits (85), Expect = 0.089
Identities = 126/662 (19%), Positives = 257/662 (38%), Gaps = 90/662 (13%)
Query: 440 KSSISSISGRDDLMDYHRRQREERLR--EQEMERLERQRLETILSL-CAEYTKPDSRLST 496
+ + S+S +L+ R + ++L EQE RL R +E L A+ K + +
Sbjct: 455 QGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL 514
Query: 497 GTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSS 556
V + +++ + L L+ ES+ E + +++L + L G L +
Sbjct: 515 HLAVRERERLQEMLMGLEAKQSESLSELITL----------REALESSHLE--GELLRQE 562
Query: 557 ASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAA 616
+ T R ++ +++L+ + + + + LS L + + + +Q+L
Sbjct: 563 QTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEAL-ALDKVGLNQQLLQ 621
Query: 617 MEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDH 676
+EE + + +E +Q + + E+ + + AL + E +L K +E
Sbjct: 622 LEEENQSVCSRMEAAEQARNALQVDLAEAEKRRE---ALWEKNTHLEA-QLQKAEEAGAE 677
Query: 677 LNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVA 736
L + ++++ EK + L ES+H ++ QLE +L +E + + L R V
Sbjct: 678 LQADLRDIQE----EKEEIQKKLS-ESRHQQEAATTQLE---QLHQEAKRQEEVLARAVQ 729
Query: 737 EYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYS 796
E KE + K +Q +R++ ++ L + + +L +++ S
Sbjct: 730 E--------KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNS 781
Query: 797 SLSGGKG-FPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLAS 855
+ KG V T+ + V + C + +Q + DA A + A A
Sbjct: 782 VIEVTKGQLEVQIQTVTQAK-EVIQGEVRCLKLELDTERSQAEQERDAAARQLAQA---- 836
Query: 856 QPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQ 915
+E +LE++K H++ + R+K S H
Sbjct: 837 ---EQEGKTALEQQKAAHEKEV----NQLREKWEKERSWHQQE----------------- 872
Query: 916 SNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHY 975
L +L ++ ++ M +M Q+ E RT +ES L
Sbjct: 873 -------LAKALESLEREKMELEMRLKEQQTEMEAIQAQREE--ERTQAES--ALCQMQL 921
Query: 976 PDHSYKDQAFDTL------SLDSSDSMETSISACSPDNISSASTSNI--ARIEEMERLLK 1027
+ +TL D+S +E + T+ I +++E +R LK
Sbjct: 922 ETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELK 981
Query: 1028 Q-AHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEV--KIRE 1084
+ A + L +E + ++ +K+ ++ + + ++ SQR L+E+EV K+RE
Sbjct: 982 EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQR--LVEQEVQEKLRE 1039
Query: 1085 RQ 1086
Q
Sbjct: 1040 TQ 1041
Score = 35.4 bits (80), Expect = 0.34
Identities = 92/496 (18%), Positives = 190/496 (38%), Gaps = 70/496 (14%)
Query: 609 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL---DMECALLDGEQKSETT 665
QR QE+ +++ + E+ + K + + Q+DE+ R L D E L EQ+
Sbjct: 1775 QREQEIVVLQQQ---LQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQG 1831
Query: 666 ELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKE 725
+ + KE D L LE+ + K + +L D H E + ++LE E ++ +
Sbjct: 1832 QEERVKEKADALQ---GALEQAHMTLKERHGELQD----HKE--QARRLEEELAVEGRRV 1882
Query: 726 NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE----QDHFVKEKNNLIMML 781
+++L ++ R +++ + AL++Q Q+ + E QD +++ + ++
Sbjct: 1883 QALEEVLGDLRAESR---EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQ---AVLK 1936
Query: 782 QREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADA 841
+R++E + SS + L+E + + G +L +
Sbjct: 1937 ERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQ--GKEQHLLEQAELSRSL 1994
Query: 842 DAVATEPATAVLASQPQSK--EHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSA 899
+A ++ A Q S+ E ++E + Q ++ Y D ++ +
Sbjct: 1995 EASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQ 2054
Query: 900 TMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFY 959
+ K+ Q N +L ++ E R + + Q++ +++
Sbjct: 2055 QEREQLLEKSLAQRVQENMIQE--KQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILE 2112
Query: 960 NRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARI 1019
R + N+ HS+K + SL DS+E +
Sbjct: 2113 LRETQQR----NNLEALPHSHKTSPMEEQSL-KLDSLEPRLQ------------------ 2149
Query: 1020 EEMERLLKQAHAEKTRLLESREREME-----AKKRA-----------LEEEKRRREILEK 1063
E+ERL + R +E RE+ + A+ +A L+ R+ ++
Sbjct: 2150 RELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQ 2209
Query: 1064 RLQEETSQRQKLIEKE 1079
RLQ+E ++ +EKE
Sbjct: 2210 RLQDELELTRRALEKE 2225
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 55.8 bits (133), Expect = 2e-07
Identities = 129/696 (18%), Positives = 264/696 (37%), Gaps = 102/696 (14%)
Query: 433 QPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEY----T 488
Q + R K S+ DDL+ RQ EE++ + ++RL+T S +Y T
Sbjct: 918 QSSQRTGKGQPSNKEDVDDLVS-QLRQTEEQVNDL------KERLKTSTSNVEQYQAMVT 970
Query: 489 KPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS 548
+ L+ V + + N E+ + ++ ++ E+ LM + K L D +
Sbjct: 971 SLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKE-----KQELQDDKRRA 1025
Query: 549 CGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEE 608
S+ Q + S+ +E+ L R S+ + + + + +
Sbjct: 1026 IESMEQQLSELKKTLSSVQNEVQEALQRASTALSN------EQQARRDCQEQAKIAVEAQ 1079
Query: 609 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELD---MECALLDGEQ----K 661
+ + + + L +E K+ + ++E+ ++ + +EC E+ K
Sbjct: 1080 NKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLK 1139
Query: 662 SETTELMKEKEILDHLNRK------------IAELEKNIVG--------EKTKDADLLDV 701
E ++ + E L+ NR +A +++ + G E +L++
Sbjct: 1140 DEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEI 1199
Query: 702 -----ESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKK-Q 755
K + F+ + ES ++ L + RE+ E Q ++ + +EK+ K
Sbjct: 1200 LRFIRREKEIAETRFEVAQVESLRYRQRVELLE---RELQELQDSLNAEREKVQVTAKTM 1256
Query: 756 ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGY 815
A H + E + V E N ML+ EKE L E+ + L+
Sbjct: 1257 AQHEELMKKTETMNVVMETNK---MLREEKERL---EQDLQQMQA------KVRKLELDI 1304
Query: 816 ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ---PQSKEHFRSLEERKKQ 872
+ + E N + + + + + D + L SQ P ++E+ + L E++
Sbjct: 1305 LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVH 1364
Query: 873 HKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAK 932
K L++ + R K + I+ +S T +++ L + + + L A
Sbjct: 1365 TKRIQQLTEEIGRLK--AEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII 1422
Query: 933 DSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDS 992
D + + Q G R K+++ A + D+ +T + S
Sbjct: 1423 DIQEKVKTIT---QVKKIGRRYKTQYEELKAQQ----------------DKVMETSAQSS 1463
Query: 993 SDSMETSISACS----PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKK 1048
D E +S + ++ A T + + ++E L K ++T +E+ ++ +
Sbjct: 1464 GDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQS 1523
Query: 1049 RALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRE 1084
E R R+ L+ R +E RQ++ EKE K R+
Sbjct: 1524 ----ELSRLRQDLQDRTTQEEQLRQQITEKEEKTRK 1555
Score = 50.8 bits (120), Expect = 8e-06
Identities = 54/238 (22%), Positives = 104/238 (43%), Gaps = 38/238 (15%)
Query: 587 KASSESSYLSI---LPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMD 643
K SE Y I L + E + E R + +E ++ N L+ L +K K++ D
Sbjct: 47 KVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLN--NQLKALTEKNKELEIAQD 104
Query: 644 ESFRELDMECALLDGEQKSETTELMKEKEIL----DHLNRKIAELEKNIVGEKTKDADL- 698
+ + + E ++E +L++ E L ++L + L + + T +L
Sbjct: 105 RNIA-IQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQ 163
Query: 699 LDVESKHFEDLEFQQLEHESRLDEEKENL--------------TQQLL-------REVAE 737
L ++ D+ + E RL++EKE L T +LL E+ E
Sbjct: 164 LKLDELQASDVSVKY--REKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE 221
Query: 738 YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
+ N+ ++KE++S L++Q N + + +H K +L+ L+ KE ++E+K+
Sbjct: 222 LKCNLENKKEEVSRLEEQMNGL----KTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF 275
Score = 48.1 bits (113), Expect = 5e-05
Identities = 67/380 (17%), Positives = 166/380 (43%), Gaps = 22/380 (5%)
Query: 424 SLRQASGTPQPA-LRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRL-ETIL 481
S Q TP P + E +I + + L + ++E+ ++++ + ++L E +
Sbjct: 646 STSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVT 705
Query: 482 SLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 541
L ++ TK ++L + ++ + N E + +++ S+ E T + + +
Sbjct: 706 DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREIT---SLHERNQKLTATTQKQEQIINT 762
Query: 542 PDADLASCGSLSQSSASFFTPRSTRNDELLSDLT--RTPPPPSSTFPKASSESSYLSILP 599
DL G+ + + + + + ++ + L+ R S + ++ L+ L
Sbjct: 763 MTQDLR--GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL- 819
Query: 600 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
+T +GI E ++ + + + + LK+K+++ +Q R LD++ +
Sbjct: 820 QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQ 879
Query: 660 QKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVES--------KHFEDLEF 711
+ET + KE+L + ++IA L++++ + + A + + +DL
Sbjct: 880 LDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVS 939
Query: 712 QQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI---VQQAQREQD 768
Q + E ++++ KE L + V +YQ + S +E ++ K+ + ++ +E
Sbjct: 940 QLRQTEEQVNDLKERL-KTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESA 998
Query: 769 HFVKEKNNLIMMLQREKENL 788
F + +M +++EK+ L
Sbjct: 999 EFQTQLEKKLMEVEKEKQEL 1018
Score = 38.5 bits (88), Expect = 0.040
Identities = 92/448 (20%), Positives = 174/448 (38%), Gaps = 54/448 (12%)
Query: 663 ETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDE 722
E+TE ++ K L L +K + + L+ + DL Q + ++LD
Sbjct: 661 ESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDF 720
Query: 723 EKENLTQQLLREVAEYQRNIVS---RKEKISALKKQANHIVQQAQREQDHFVKEKNNLIM 779
+ + L V Y+R I S R +K++A ++ I+ ++ ++ N +
Sbjct: 721 ASKRY-EMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQD----LRGANEKLA 775
Query: 780 MLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPA 839
+ + ENL EK+ LS V + +E ++ E G + L+
Sbjct: 776 VAEVRAENL-KKEKEMLKLS-----EVRLSQQRESLLA-----EQRGQNLLLTNLQTIQG 824
Query: 840 DADAVATEPATAVLASQPQSKEHFRSLEERKKQHKE----------GLYLSDTLPRKKTT 889
+ TE L+SQ + EH S ++K +++ + L DT + T
Sbjct: 825 ILERSETETKQR-LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTE 883
Query: 890 SSISPHFSSATMGRSI-----TPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 944
+++ H ++ + ++ T K HL SN V S K S +
Sbjct: 884 TNL--HLNTKELLKNAQKEIATLKQHL----SNMEVQVASQSSQRTGKGQPSNKEDVDDL 937
Query: 945 HQQMSEGHRQKSEFYNRT-ASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISAC 1003
Q+ + Q ++ R S SNV + QA T SL+ S + E ++
Sbjct: 938 VSQLRQTEEQVNDLKERLKTSTSNVE-----------QYQAMVT-SLEESLNKEKQVTEE 985
Query: 1004 SPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK 1063
NI + ++E+ L + EK L + + R +E+ ++ L E K+ ++
Sbjct: 986 VRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQN 1045
Query: 1064 RLQEETSQRQKLIEKEVKIRERQRAQAR 1091
+QE + + E + R + QA+
Sbjct: 1046 EVQEALQRASTALSNEQQARRDCQEQAK 1073
Score = 37.7 bits (86), Expect = 0.068
Identities = 85/404 (21%), Positives = 157/404 (38%), Gaps = 78/404 (19%)
Query: 435 ALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRL 494
AL E+ + R+ + + +E L E E+ + R LS EY
Sbjct: 91 ALTEKNKELEIAQDRNIAIQSQFTRTKEEL---EAEKRDLIRTNERLSQELEYL------ 141
Query: 495 STGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYRCHRKDSLPDADLASCGSLS 553
EDV+++N++L++ + E + + L + D + K + +L L
Sbjct: 142 -----TEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKEL-----LH 191
Query: 554 QSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQE 613
+ T T+ DELL+ L R K + L E +S + ++
Sbjct: 192 SQNTWLNTELKTKTDELLA-LGRE---------KGNEILELKCNLENKKEEVSRLE--EQ 239
Query: 614 LAAMEETRIVILNNLEELKQKIKDINDQ---MDESFR-ELDMECALLDGEQKSETTELMK 669
+ ++ + + ++E+L K+K+ +Q M+E F EL+ L + + + K
Sbjct: 240 MNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAK 299
Query: 670 EKEILDHLNRKIAELEKNI--VGEKTKDAD--LLDVESKHFEDLEFQQLEHESRLDEEKE 725
E L R + EL K + GE K LL+VE + +E + LE RL++E E
Sbjct: 300 SNE----LTRAVEELHKLLKEAGEANKAIQDHLLEVEQSK-DQMEKEMLEKIGRLEKELE 354
Query: 726 NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ------------------------ 761
N L A ++ + +E+++A+ A + +
Sbjct: 355 NANDLLS---ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
Query: 762 ------QAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS 799
+ + D VKE +L+R++E +K +SLS
Sbjct: 412 EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLS 455
Score = 31.2 bits (69), Expect = 6.4
Identities = 27/107 (25%), Positives = 48/107 (44%), Gaps = 7/107 (6%)
Query: 994 DSMETSISACSPDN--ISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRAL 1051
+ + + A + N + A NIA + R ++ AEK L+ + ER + +
Sbjct: 83 EKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLT 142
Query: 1052 EEEKRRREILEKRLQEETSQRQKLIEKE-----VKIRERQRAQARPL 1093
E+ KR E L++ + + KL E + VK RE++ Q + L
Sbjct: 143 EDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKEL 189
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 55.5 bits (132), Expect = 3e-07
Identities = 79/392 (20%), Positives = 170/392 (43%), Gaps = 43/392 (10%)
Query: 413 GSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQE--ME 470
G ++ + + L + L++++ +S + + D H Q +++++E + +E
Sbjct: 1061 GDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIE 1120
Query: 471 RLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 530
LE + +E +L A+ K S L+ ++++I++ LE + S S E +
Sbjct: 1121 ELEEE-IEAEHTLRAKIEKQRSDLA-----RELEEISERLE--EASGATSAQIEMNKKRE 1172
Query: 531 TRYRCHRKDSLPDADL---ASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPK 587
++ R+D L +A L A+ +L + A + D L + S +
Sbjct: 1173 AEFQKMRRD-LEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME 1231
Query: 588 ASSESSYLSILPKTPEGISE-----EQRSQELAAMEETRIVILNNLEELKQKIKDINDQM 642
+S + L K+ I E + E+ A +E + ++++L K +++ N ++
Sbjct: 1232 IDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGEL 1291
Query: 643 DESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGE-KTKDADLLDV 701
E ++S ++L K K+ L +++ EL++ + E K K+A +
Sbjct: 1292 SHRVEE-----------KESLISQLTKSKQAL---TQQLEELKRQMEEETKAKNAMAHAL 1337
Query: 702 ES-KHFEDLEFQQLEHESRLDEEKENLTQQLLREVAE----YQRNIVSRKEKISALKKQA 756
+S +H DL +Q E E E + + EVA+ Y+ + + R E++ KK+
Sbjct: 1338 QSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1397
Query: 757 NHIVQQAQREQDHFVKEKNNLIMMLQREKENL 788
+Q+A+ + N+ L++ K+ L
Sbjct: 1398 AQRLQEAEEN----TETANSKCASLEKTKQRL 1425
Score = 46.6 bits (109), Expect = 1e-04
Identities = 76/372 (20%), Positives = 151/372 (40%), Gaps = 35/372 (9%)
Query: 415 VEFDE--ADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERL 472
+E D+ +++E+L ++ + R + S I +D+ Q+ + + + M++
Sbjct: 1230 MEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDE-------QQTQLIHDLNMQKA 1282
Query: 473 ERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTR 532
Q LS E + +S +S T + Q + ++LE+L+ EE + M+ +
Sbjct: 1283 RLQTQNGELSHRVE--EKESLISQLT--KSKQALTQQLEELKRQMEEETKAKNAMAHALQ 1338
Query: 533 YRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSES 592
H D L + ++ A S N E+ T+ +
Sbjct: 1339 SSRHDCDLLRE----QYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1394
Query: 593 SYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDME 652
L+ QR QE ET +LE+ KQ+++ + +
Sbjct: 1395 KKLA------------QRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA 1442
Query: 653 CALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQ 712
CA LD +Q++ L + K+ LD ++ +K T+ + + + + LE
Sbjct: 1443 CATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETL 1502
Query: 713 QLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVK 772
+ E+++ L EE +LT+Q +AE +N+ EK L +Q +Q A E + ++
Sbjct: 1503 RRENKN-LQEEISDLTEQ----IAETGKNL-QEAEKTKKLVEQEKSDLQVALEEVEGSLE 1556
Query: 773 EKNNLIMMLQRE 784
+ + I+ +Q E
Sbjct: 1557 HEESKILRVQLE 1568
Score = 45.1 bits (105), Expect = 4e-04
Identities = 41/209 (19%), Positives = 88/209 (42%), Gaps = 16/209 (7%)
Query: 606 SEEQRSQELAAMEETRIVILNNLEELKQKIKDIND---QMDESFRELDMECALLDGEQKS 662
S EQ + A +E + + +L+ ++ I D+ + Q++E ++ + E + L +
Sbjct: 1041 SLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDD 1100
Query: 663 ETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLE------------ 710
E ++ ++ + L +I ELE+ I E T A + S +LE
Sbjct: 1101 EQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGA 1160
Query: 711 -FQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDH 769
Q+E + + E + + + L +++ + ++K + + + QR +
Sbjct: 1161 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK 1220
Query: 770 FVKEKNNLIMMLQREKENLCNLEKKYSSL 798
KEK+ L M + N+ L K S++
Sbjct: 1221 LEKEKSELKMEIDDMASNIEALSKSKSNI 1249
Score = 38.9 bits (89), Expect = 0.031
Identities = 78/387 (20%), Positives = 166/387 (42%), Gaps = 53/387 (13%)
Query: 439 RKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS-TG 497
RK S++ + +D +R +++ +E+ ++E ++ + S +K S + T
Sbjct: 1197 RKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME---IDDMASNIEALSKSKSNIERTC 1253
Query: 498 TTVED---------------VQKINKELEKLQLSDEESVF----EEALMSPDTRYRCHRK 538
TVED + +N + +LQ + E +E+L+S T+ +
Sbjct: 1254 RTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALT 1313
Query: 539 DSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSIL 598
L + +A +S+R+D DL R + +++ L
Sbjct: 1314 QQLEELKRQMEEETKAKNAMAHALQSSRHD---CDLLR-----EQYEEEQEAKAELQRAL 1365
Query: 599 PKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDG 658
K +++ + E A++ T LEE K+K+ + +E+ + +CA L+
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTE-----ELEEAKKKLAQRLQEAEENTETANSKCASLEK 1420
Query: 659 EQ---KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFE---DLEFQ 712
+ + E +LM++ L+ + A L+K ++ D L + + K E +LE
Sbjct: 1421 TKQRLQGEVEDLMRD---LERSHTACATLDKK---QRNFDKVLAEWKQKLDESQAELEAA 1474
Query: 713 QLEHESRLDE--EKENLTQQLLREVAEYQRNIVSRKEKISALKKQ---ANHIVQQAQREQ 767
Q E S E + N ++++ ++ +R + +E+IS L +Q +Q+A++ +
Sbjct: 1475 QKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTK 1534
Query: 768 DHFVKEKNNLIMMLQREKENLCNLEKK 794
+EK++L + L+ + +L + E K
Sbjct: 1535 KLVEQEKSDLQVALEEVEGSLEHEESK 1561
Score = 38.1 bits (87), Expect = 0.052
Identities = 72/360 (20%), Positives = 151/360 (41%), Gaps = 43/360 (11%)
Query: 415 VEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEME--RL 472
+E DE ++E L++ S AL+ + I R+D + +++ E L E E++
Sbjct: 1581 IEKDE-EIEQLKRNSQRAAEALQSVLDA--EIRSRNDALRL-KKKMEGDLNEMEIQLGHS 1636
Query: 473 ERQRLETILSL-CAEYTKPDSRLSTGTTVEDVQKINKEL-EKLQLSDEES--VFEEALMS 528
RQ ET L + DS+L ++D + N++L E+L + + + + EE
Sbjct: 1637 NRQMAETQKHLRTVQGQLKDSQLH----LDDALRSNEDLKEQLAIVERRNGLLLEELEEM 1692
Query: 529 PDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKA 588
+ R L + +L Q S T +L +D+ + ++ ++
Sbjct: 1693 KVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQES 1752
Query: 589 SSESSYLSILPKTPEGISEE-QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFR 647
+ K + I++ ++EL ++T + + L+Q +KD+ ++DE
Sbjct: 1753 RNAEE------KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE--- 1803
Query: 648 ELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFE 707
+E L K+ + L ++ ELE + E+ + A+ L + H
Sbjct: 1804 --------------AEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEAL--KGAHKY 1847
Query: 708 DLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQ 767
+ + +++ +++ D + Q L V + Q + S K + ++QAN + + +R Q
Sbjct: 1848 ERKVKEMTYQAEEDHKNILRLQDL---VDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQ 1904
Score = 35.8 bits (81), Expect = 0.26
Identities = 37/145 (25%), Positives = 60/145 (41%), Gaps = 37/145 (25%)
Query: 1017 ARIEEMERLLKQAHAEKTRLLESRE---REMEA-------------------KKRALEEE 1054
ARIEE+E ++ H + ++ + R RE+E KKR E +
Sbjct: 1117 ARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQ 1176
Query: 1055 KRRREILEKRLQEETS-------QRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR 1107
K RR++ E LQ E + Q + E +I QR + + + KE +L+
Sbjct: 1177 KMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK-------LEKEKSELK 1229
Query: 1108 SHVETAGHNIDT-CYHVSITEKTCR 1131
++ NI+ S E+TCR
Sbjct: 1230 MEIDDMASNIEALSKSKSNIERTCR 1254
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 55.1 bits (131), Expect = 4e-07
Identities = 145/741 (19%), Positives = 292/741 (39%), Gaps = 88/741 (11%)
Query: 425 LRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLC 484
+R+ + + A ++ +S ++ +++ H + + + +Q++E+ Q +E+
Sbjct: 504 IRKRTAEHEAAQQDLQSKF--VAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES----- 556
Query: 485 AEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDA 544
E + + S V+D+ + N+ L K Q+ S + H+ + D
Sbjct: 557 -EQKRVNKEESLQMQVQDILEQNEAL-KAQIQQFHSQIAAQTSASVLAEELHKVIAEKDK 614
Query: 545 DLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPK----ASSESSYLSILPK 600
+ ++ S + R T +E L D+ + K A+ +++ L K
Sbjct: 615 QIKQ----TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEK 670
Query: 601 TPEGIS---------EEQRSQELA-AMEETRIVILNN--LEELKQKI---------KDIN 639
+ + EEQ E++ MEE +I+ N L+ QK+ KD+
Sbjct: 671 MQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV 730
Query: 640 DQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL 699
+QM++ +E D + ++ ++ ++ ++E L+ + + + L K + K K D +
Sbjct: 731 EQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQV 790
Query: 700 DVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI 759
S E+L+ E + ++ +E L +LL+ VA ++ + K++I ALK++ ++
Sbjct: 791 SFASL-VEELKKVIHEKDGKIKSVEELLEAELLK-VANKEKTVQDLKQEIKALKEEIGNV 848
Query: 760 VQQAQREQDHFVKEKNNLIMMLQREKENLCN-----LEKKYSSLSG-GKGFPVNPNTLKE 813
Q ++ Q + K + L + KE N LE+K L+ GK +
Sbjct: 849 --QLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENES 906
Query: 814 GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKK-- 871
V E+ + N S ++QF + + V E + + KE L + +
Sbjct: 907 LKAHVQEVAQ--HNLKEASSASQF-EELEIVLKEKENELKRLEAMLKERESDLSSKTQLL 963
Query: 872 ---QHKEGLYLSDTLPRK----KTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLP 924
Q + L+ S K + SS PH + + I+ + G N S L
Sbjct: 964 QDVQDENKLFKSQIEQLKQQNYQQASSFPPH---EELLKVISEREKEISGLWNELDS-LK 1019
Query: 925 PSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQA 984
++ K + R + ++ + + N+T+ E + + +
Sbjct: 1020 DAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKL 1079
Query: 985 FDTLSLDSSDS-------METSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLL 1037
F +S+ S+ S E C A TS ++ +E LK+A T L
Sbjct: 1080 FPKVSVPSNLSYGEWLHGFEKKAKEC------MAGTSGSEEVKVLEHKLKEADEMHTLL- 1132
Query: 1038 ESREREMEAKKRALEEEKRRREILEKRL-QEETSQRQKLIEKEVKIRERQRAQARPLTRY 1096
+ E E K L E + + L++ + QEE + K+ E I++ Q +
Sbjct: 1133 ---QLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQEL 1189
Query: 1097 LPVRKEDFDL------RSHVE 1111
+R E+ D+ R H+E
Sbjct: 1190 ERLRSENKDIENLRREREHLE 1210
Score = 46.2 bits (108), Expect = 2e-04
Identities = 67/328 (20%), Positives = 126/328 (38%), Gaps = 29/328 (8%)
Query: 436 LRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS 495
LRE+ + M + + + R+Q++E +E + E + L + + P S LS
Sbjct: 1032 LREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVP-SNLS 1090
Query: 496 TGTTVEDVQKINKE-LEKLQLSDEESVFEEALMSPDTRY-----RCHRKDSLPDADLASC 549
G + +K KE + S+E V E L D + C + S+ LA
Sbjct: 1091 YGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSV----LAET 1146
Query: 550 GSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQ 609
+ Q + + + +T S+F + E L K E + E+
Sbjct: 1147 EGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRER 1206
Query: 610 R--SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL---DMECALLDGEQKSET 664
EL E R + + ELK + ++ ++D+S+ E + E LL +
Sbjct: 1207 EHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETL 1266
Query: 665 TELMKEKEILD------HLNRKIAELEKNIVGEKTKDADLL-------DVESKHFEDLEF 711
T+L E+ H ++ EL ++ + + D ++ + ES E +
Sbjct: 1267 TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSV 1326
Query: 712 QQLEHESRLDEEKENLTQQLLREVAEYQ 739
+ ++L + + + QQL +E YQ
Sbjct: 1327 SLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1354
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 55.1 bits (131), Expect = 4e-07
Identities = 145/741 (19%), Positives = 292/741 (39%), Gaps = 88/741 (11%)
Query: 425 LRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLC 484
+R+ + + A ++ +S ++ +++ H + + + +Q++E+ Q +E+
Sbjct: 504 IRKRTAEHEAAQQDLQSKF--VAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES----- 556
Query: 485 AEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDA 544
E + + S V+D+ + N+ L K Q+ S + H+ + D
Sbjct: 557 -EQKRVNKEESLQMQVQDILEQNEAL-KAQIQQFHSQIAAQTSASVLAEELHKVIAEKDK 614
Query: 545 DLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPK----ASSESSYLSILPK 600
+ ++ S + R T +E L D+ + K A+ +++ L K
Sbjct: 615 QIKQ----TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEK 670
Query: 601 TPEGIS---------EEQRSQELA-AMEETRIVILNN--LEELKQKI---------KDIN 639
+ + EEQ E++ MEE +I+ N L+ QK+ KD+
Sbjct: 671 MQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV 730
Query: 640 DQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL 699
+QM++ +E D + ++ ++ ++ ++E L+ + + + L K + K K D +
Sbjct: 731 EQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQV 790
Query: 700 DVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI 759
S E+L+ E + ++ +E L +LL+ VA ++ + K++I ALK++ ++
Sbjct: 791 SFASL-VEELKKVIHEKDGKIKSVEELLEAELLK-VANKEKTVQDLKQEIKALKEEIGNV 848
Query: 760 VQQAQREQDHFVKEKNNLIMMLQREKENLCN-----LEKKYSSLSG-GKGFPVNPNTLKE 813
Q ++ Q + K + L + KE N LE+K L+ GK +
Sbjct: 849 --QLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENES 906
Query: 814 GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKK-- 871
V E+ + N S ++QF + + V E + + KE L + +
Sbjct: 907 LKAHVQEVAQ--HNLKEASSASQF-EELEIVLKEKENELKRLEAMLKERESDLSSKTQLL 963
Query: 872 ---QHKEGLYLSDTLPRK----KTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLP 924
Q + L+ S K + SS PH + + I+ + G N S L
Sbjct: 964 QDVQDENKLFKSQIEQLKQQNYQQASSFPPH---EELLKVISEREKEISGLWNELDS-LK 1019
Query: 925 PSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQA 984
++ K + R + ++ + + N+T+ E + + +
Sbjct: 1020 DAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKL 1079
Query: 985 FDTLSLDSSDS-------METSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLL 1037
F +S+ S+ S E C A TS ++ +E LK+A T L
Sbjct: 1080 FPKVSVPSNLSYGEWLHGFEKKAKEC------MAGTSGSEEVKVLEHKLKEADEMHTLL- 1132
Query: 1038 ESREREMEAKKRALEEEKRRREILEKRL-QEETSQRQKLIEKEVKIRERQRAQARPLTRY 1096
+ E E K L E + + L++ + QEE + K+ E I++ Q +
Sbjct: 1133 ---QLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQEL 1189
Query: 1097 LPVRKEDFDL------RSHVE 1111
+R E+ D+ R H+E
Sbjct: 1190 ERLRSENKDIENLRREREHLE 1210
Score = 46.2 bits (108), Expect = 2e-04
Identities = 67/328 (20%), Positives = 126/328 (38%), Gaps = 29/328 (8%)
Query: 436 LRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS 495
LRE+ + M + + + R+Q++E +E + E + L + + P S LS
Sbjct: 1032 LREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVP-SNLS 1090
Query: 496 TGTTVEDVQKINKE-LEKLQLSDEESVFEEALMSPDTRY-----RCHRKDSLPDADLASC 549
G + +K KE + S+E V E L D + C + S+ LA
Sbjct: 1091 YGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSV----LAET 1146
Query: 550 GSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQ 609
+ Q + + + +T S+F + E L K E + E+
Sbjct: 1147 EGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRER 1206
Query: 610 R--SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL---DMECALLDGEQKSET 664
EL E R + + ELK + ++ ++D+S+ E + E LL +
Sbjct: 1207 EHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETL 1266
Query: 665 TELMKEKEILD------HLNRKIAELEKNIVGEKTKDADLL-------DVESKHFEDLEF 711
T+L E+ H ++ EL ++ + + D ++ + ES E +
Sbjct: 1267 TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSV 1326
Query: 712 QQLEHESRLDEEKENLTQQLLREVAEYQ 739
+ ++L + + + QQL +E YQ
Sbjct: 1327 SLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1354
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 54.3 bits (129), Expect = 7e-07
Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)
Query: 416 EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 474
E E +LE RQ A GT Q L + I + + + +++ +L E+E+ RL+R
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1741
Query: 475 Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 527
+ R E L + + L++ E+ + E K +L E F E L
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1800
Query: 528 SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 585
R R +++ LA + Q + + ++L + + TR
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1856
Query: 586 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 645
+ +E+ L L + + + +R +E AA + ++EE +++ +D E
Sbjct: 1857 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1908
Query: 646 FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 704
+ L +E L Q E E++ K + AELE + ++ D L E
Sbjct: 1909 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1965
Query: 705 HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 760
E +QL E E R E +E + + L E A ++ + E++ A ++A +
Sbjct: 1966 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2025
Query: 761 QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
++A++E ++ EK + + Q+E+E L+++ S L +G
Sbjct: 2026 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2085
Query: 808 PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 865
E V E + + + + A+ A A A A++ KE +
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2145
Query: 866 LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 922
R + + L +D K + A + + +T L L +++ ++
Sbjct: 2146 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2204
Query: 923 LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 979
L L + ++ R +++ Q E R +E+ +
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 980 YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1035
+ + + + + ++ S++A + + ++A+ + E++LK QA E TR
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 1036 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1079
L E + K+ A E+ +R +E E+ +L EET Q+ +E E
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 1080 --VKIRERQRAQAR 1091
+++ E RAQAR
Sbjct: 2385 LKLRVAEMSRAQAR 2398
Score = 48.5 bits (114), Expect = 4e-05
Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)
Query: 600 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
K E I E+ ELA E ++ ++ LE +Q+ +++ E+ EL+ E L E
Sbjct: 2408 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465
Query: 660 QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 704
K SE + ++++++L L+ K + + E+ I EK K L E
Sbjct: 2466 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525
Query: 705 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
+ L +Q + ++++E+ Q+L+ + E +R +E + +++ + QQ +
Sbjct: 2526 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2580
Query: 765 REQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
R+Q+ + E+N QR +E L LE+++
Sbjct: 2581 RQQEELLAEEN------QRLREQLQLLEEQH 2605
Score = 45.1 bits (105), Expect = 4e-04
Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)
Query: 227 SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 286
+MP + QA + ++ AL ++ RH E E ++++ ++ + Y L
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1288
Query: 287 YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 341
Y+A QL P++ P + + + G + + +D +Y ++L+S + +
Sbjct: 1289 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340
Query: 342 -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 394
+ A + L+ + ++ L + + + +A +
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400
Query: 395 LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 438
++ E V A ++ S + EA++++ RQA + LR +
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 439 RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 492
+++ G + + R + EE R ++E ERL RQ + E+ AE
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520
Query: 493 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
+ + Q+ + LE+L+L EE+ E L + + +L A ++ L
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 553 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
ASF E + L R S + ++++ E E+R+Q
Sbjct: 1579 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1615
Query: 613 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
+ A E R EE +++++ + +E+ R L ++ + ++ E K+KE
Sbjct: 1616 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1667
Query: 673 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
+ R+ + E+ V ++ L+ + + E + RL E+E + +
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1721
Query: 733 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 788
E E QR ++ +E+++ L+++A Q+ Q + K + + ++L + E+E+
Sbjct: 1722 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 789 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 846
EK L G L E + + E L+ + + A+A+ V
Sbjct: 1780 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836
Query: 847 EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 877
E A+ +A + + E+ R LEE+ QHK +
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896
Query: 878 ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 918
+ DTL +++ ++ F A G++ + L LG+ S
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1953
Query: 919 CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 969
+ L + E RR Q S +++ + A E
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 970 LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1029
L + +++A +S+ ++ + A + + + ++ +++ E+ L+Q
Sbjct: 2014 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 1030 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1083
++ +L+ E EA +RA EE + RE + R Q E ++R K E++ + R
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128
Query: 1084 ERQRAQARPLTR 1095
+ +A A L +
Sbjct: 2129 AQAQAAAEKLRK 2140
Score = 45.1 bits (105), Expect = 4e-04
Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)
Query: 401 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 460
+ + A + +F + E +LE R S + ++ + + R + RR+R
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1984
Query: 461 EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 520
E R Q+ SL AE R + +E+V+++ ++E+ + E +
Sbjct: 1985 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2028
Query: 521 VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 580
E A + ++ L + A ++ Q ++ + ++ + D R
Sbjct: 2029 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2081
Query: 581 PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 638
+ +A+ E+ + + S Q ++ L E + + +K++
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 639 NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 698
+Q E+ R E A L +Q ++ E+ K K+ + R+ A++E+ + +
Sbjct: 2142 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2192
Query: 699 LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 758
L+ ++ +H+ L +E+ Q+L E E R +E++ +++ Q
Sbjct: 2193 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 759 IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 814
+ + +A+ E ++ +++K+N LQ E E + + ++ + LS L E
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299
Query: 815 YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 863
++ + E + +T L + +A E A + + Q +
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359
Query: 864 ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 917
R+LE +++ E ++ L K + +S + A K +G+
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 918 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 971
+ + + E +R ++ +++ E + + E+ + +
Sbjct: 2418 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2477
Query: 972 SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 1021
+ + QA L DS+ + + D ++ A EE
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2533
Query: 1022 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1081
+R +Q E+ RL+ S E + A E +R++E L++ Q+ Q + L E+ +
Sbjct: 2534 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593
Query: 1082 IRER 1085
+RE+
Sbjct: 2594 LREQ 2597
Score = 41.6 bits (96), Expect = 0.005
Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)
Query: 419 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 474
EA+L+S R AS + A ER ++ + RR ++ ER RE+ LER
Sbjct: 1575 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Query: 475 QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 530
+L+ L L AE L+ + ++ +E + ++E++V + L +
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Query: 531 TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 589
+ + LA+ L + A T + + +LL + L R ++ K
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1751
Query: 590 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 649
+ L+ + E + + E EE+R + E+ KQ+++ + FREL
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1799
Query: 650 DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 708
E A L ++ E +++++ + R+ AE E+ + + + ++++
Sbjct: 1800 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
Query: 709 LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 766
L+ ++ E+E RL E++ ++L + A+++ +I +E+++ L+K ++ +++ +
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1912
Query: 767 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 826
+ ++++ + +E + L+ + + GK E + + I
Sbjct: 1913 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1956
Query: 827 NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 885
++ + A +A E ++ + ++ + EE +Q K L + L
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016
Query: 886 KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 945
K + + R + + Q + A K+ E ++ L+
Sbjct: 2017 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2072
Query: 946 QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 1005
Q + + R ++E R A E+ + ++ A ++ ++ ++ S +
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126
Query: 1006 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1055
+ + + E+L K+A E R ++ + EME K+ E+
Sbjct: 2127 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 1056 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1108
R++ +E+ L EET ++ L+++E+ +R +A+A R V +E F +R
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2235
Query: 1109 HVE 1111
+E
Sbjct: 2236 QME 2238
Score = 34.3 bits (77), Expect = 0.76
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)
Query: 1020 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1066
+E+E L + AE LL S+ R E + E+ K+R RE+ E + L
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810
Query: 1067 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1113
EE ++++L E++ RQRA+A R L L E L++ E A
Sbjct: 1811 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 54.3 bits (129), Expect = 7e-07
Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)
Query: 416 EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 474
E E +LE RQ A GT Q L + I + + + +++ +L E+E+ RL+R
Sbjct: 1692 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1745
Query: 475 Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 527
+ R E L + + L++ E+ + E K +L E F E L
Sbjct: 1746 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1804
Query: 528 SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 585
R R +++ LA + Q + + ++L + + TR
Sbjct: 1805 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1860
Query: 586 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 645
+ +E+ L L + + + +R +E AA + ++EE +++ +D E
Sbjct: 1861 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1912
Query: 646 FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 704
+ L +E L Q E E++ K + AELE + ++ D L E
Sbjct: 1913 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1969
Query: 705 HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 760
E +QL E E R E +E + + L E A ++ + E++ A ++A +
Sbjct: 1970 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2029
Query: 761 QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
++A++E ++ EK + + Q+E+E L+++ S L +G
Sbjct: 2030 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2089
Query: 808 PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 865
E V E + + + + A+ A A A A++ KE +
Sbjct: 2090 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2149
Query: 866 LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 922
R + + L +D K + A + + +T L L +++ ++
Sbjct: 2150 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2208
Query: 923 LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 979
L L + ++ R +++ Q E R +E+ +
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268
Query: 980 YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1035
+ + + + + ++ S++A + + ++A+ + E++LK QA E TR
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328
Query: 1036 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1079
L E + K+ A E+ +R +E E+ +L EET Q+ +E E
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388
Query: 1080 --VKIRERQRAQAR 1091
+++ E RAQAR
Sbjct: 2389 LKLRVAEMSRAQAR 2402
Score = 48.5 bits (114), Expect = 4e-05
Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)
Query: 600 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
K E I E+ ELA E ++ ++ LE +Q+ +++ E+ EL+ E L E
Sbjct: 2412 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2469
Query: 660 QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 704
K SE + ++++++L L+ K + + E+ I EK K L E
Sbjct: 2470 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2529
Query: 705 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
+ L +Q + ++++E+ Q+L+ + E +R +E + +++ + QQ +
Sbjct: 2530 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2584
Query: 765 REQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
R+Q+ + E+N QR +E L LE+++
Sbjct: 2585 RQQEELLAEEN------QRLREQLQLLEEQH 2609
Score = 45.1 bits (105), Expect = 4e-04
Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)
Query: 227 SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 286
+MP + QA + ++ AL ++ RH E E ++++ ++ + Y L
Sbjct: 1239 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1292
Query: 287 YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 341
Y+A QL P++ P + + + G + + +D +Y ++L+S + +
Sbjct: 1293 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1344
Query: 342 -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 394
+ A + L+ + ++ L + + + +A +
Sbjct: 1345 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1404
Query: 395 LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 438
++ E V A ++ S + EA++++ RQA + LR +
Sbjct: 1405 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1464
Query: 439 RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 492
+++ G + + R + EE R ++E ERL RQ + E+ AE
Sbjct: 1465 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1524
Query: 493 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
+ + Q+ + LE+L+L EE+ E L + + +L A ++ L
Sbjct: 1525 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1582
Query: 553 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
ASF E + L R S + ++++ E E+R+Q
Sbjct: 1583 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1619
Query: 613 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
+ A E R EE +++++ + +E+ R L ++ + ++ E K+KE
Sbjct: 1620 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1671
Query: 673 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
+ R+ + E+ V ++ L+ + + E + RL E+E + +
Sbjct: 1672 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1725
Query: 733 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 788
E E QR ++ +E+++ L+++A Q+ Q + K + + ++L + E+E+
Sbjct: 1726 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783
Query: 789 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 846
EK L G L E + + E L+ + + A+A+ V
Sbjct: 1784 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1840
Query: 847 EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 877
E A+ +A + + E+ R LEE+ QHK +
Sbjct: 1841 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1900
Query: 878 ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 918
+ DTL +++ ++ F A G++ + L LG+ S
Sbjct: 1901 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1957
Query: 919 CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 969
+ L + E RR Q S +++ + A E
Sbjct: 1958 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2017
Query: 970 LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1029
L + +++A +S+ ++ + A + + + ++ +++ E+ L+Q
Sbjct: 2018 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2072
Query: 1030 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1083
++ +L+ E EA +RA EE + RE + R Q E ++R K E++ + R
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2132
Query: 1084 ERQRAQARPLTR 1095
+ +A A L +
Sbjct: 2133 AQAQAAAEKLRK 2144
Score = 45.1 bits (105), Expect = 4e-04
Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)
Query: 401 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 460
+ + A + +F + E +LE R S + ++ + + R + RR+R
Sbjct: 1929 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1988
Query: 461 EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 520
E R Q+ SL AE R + +E+V+++ ++E+ + E +
Sbjct: 1989 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2032
Query: 521 VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 580
E A + ++ L + A ++ Q ++ + ++ + D R
Sbjct: 2033 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2085
Query: 581 PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 638
+ +A+ E+ + + S Q ++ L E + + +K++
Sbjct: 2086 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2145
Query: 639 NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 698
+Q E+ R E A L +Q ++ E+ K K+ + R+ A++E+ + +
Sbjct: 2146 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2196
Query: 699 LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 758
L+ ++ +H+ L +E+ Q+L E E R +E++ +++ Q
Sbjct: 2197 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243
Query: 759 IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 814
+ + +A+ E ++ +++K+N LQ E E + + ++ + LS L E
Sbjct: 2244 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2303
Query: 815 YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 863
++ + E + +T L + +A E A + + Q +
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2363
Query: 864 ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 917
R+LE +++ E ++ L K + +S + A K +G+
Sbjct: 2364 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421
Query: 918 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 971
+ + + E +R ++ +++ E + + E+ + +
Sbjct: 2422 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2481
Query: 972 SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 1021
+ + QA L DS+ + + D ++ A EE
Sbjct: 2482 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2537
Query: 1022 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1081
+R +Q E+ RL+ S E + A E +R++E L++ Q+ Q + L E+ +
Sbjct: 2538 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2597
Query: 1082 IRER 1085
+RE+
Sbjct: 2598 LREQ 2601
Score = 41.6 bits (96), Expect = 0.005
Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)
Query: 419 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 474
EA+L+S R AS + A ER ++ + RR ++ ER RE+ LER
Sbjct: 1579 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637
Query: 475 QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 530
+L+ L L AE L+ + ++ +E + ++E++V + L +
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1697
Query: 531 TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 589
+ + LA+ L + A T + + +LL + L R ++ K
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1755
Query: 590 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 649
+ L+ + E + + E EE+R + E+ KQ+++ + FREL
Sbjct: 1756 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1803
Query: 650 DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 708
E A L ++ E +++++ + R+ AE E+ + + + ++++
Sbjct: 1804 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1859
Query: 709 LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 766
L+ ++ E+E RL E++ ++L + A+++ +I +E+++ L+K ++ +++ +
Sbjct: 1860 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1916
Query: 767 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 826
+ ++++ + +E + L+ + + GK E + + I
Sbjct: 1917 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1960
Query: 827 NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 885
++ + A +A E ++ + ++ + EE +Q K L + L
Sbjct: 1961 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2020
Query: 886 KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 945
K + + R + + Q + A K+ E ++ L+
Sbjct: 2021 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2076
Query: 946 QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 1005
Q + + R ++E R A E+ + ++ A ++ ++ ++ S +
Sbjct: 2077 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2130
Query: 1006 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1055
+ + + E+L K+A E R ++ + EME K+ E+
Sbjct: 2131 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182
Query: 1056 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1108
R++ +E+ L EET ++ L+++E+ +R +A+A R V +E F +R
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2239
Query: 1109 HVE 1111
+E
Sbjct: 2240 QME 2242
Score = 34.3 bits (77), Expect = 0.76
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)
Query: 1020 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1066
+E+E L + AE LL S+ R E + E+ K+R RE+ E + L
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1814
Query: 1067 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1113
EE ++++L E++ RQRA+A R L L E L++ E A
Sbjct: 1815 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1859
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 54.3 bits (129), Expect = 7e-07
Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)
Query: 416 EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 474
E E +LE RQ A GT Q L + I + + + +++ +L E+E+ RL+R
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1741
Query: 475 Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 527
+ R E L + + L++ E+ + E K +L E F E L
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1800
Query: 528 SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 585
R R +++ LA + Q + + ++L + + TR
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1856
Query: 586 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 645
+ +E+ L L + + + +R +E AA + ++EE +++ +D E
Sbjct: 1857 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1908
Query: 646 FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 704
+ L +E L Q E E++ K + AELE + ++ D L E
Sbjct: 1909 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1965
Query: 705 HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 760
E +QL E E R E +E + + L E A ++ + E++ A ++A +
Sbjct: 1966 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2025
Query: 761 QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
++A++E ++ EK + + Q+E+E L+++ S L +G
Sbjct: 2026 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2085
Query: 808 PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 865
E V E + + + + A+ A A A A++ KE +
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2145
Query: 866 LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 922
R + + L +D K + A + + +T L L +++ ++
Sbjct: 2146 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2204
Query: 923 LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 979
L L + ++ R +++ Q E R +E+ +
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 980 YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1035
+ + + + + ++ S++A + + ++A+ + E++LK QA E TR
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 1036 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1079
L E + K+ A E+ +R +E E+ +L EET Q+ +E E
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 1080 --VKIRERQRAQAR 1091
+++ E RAQAR
Sbjct: 2385 LKLRVAEMSRAQAR 2398
Score = 48.5 bits (114), Expect = 4e-05
Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)
Query: 600 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
K E I E+ ELA E ++ ++ LE +Q+ +++ E+ EL+ E L E
Sbjct: 2408 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465
Query: 660 QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 704
K SE + ++++++L L+ K + + E+ I EK K L E
Sbjct: 2466 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525
Query: 705 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
+ L +Q + ++++E+ Q+L+ + E +R +E + +++ + QQ +
Sbjct: 2526 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2580
Query: 765 REQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
R+Q+ + E+N QR +E L LE+++
Sbjct: 2581 RQQEELLAEEN------QRLREQLQLLEEQH 2605
Score = 45.1 bits (105), Expect = 4e-04
Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)
Query: 227 SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 286
+MP + QA + ++ AL ++ RH E E ++++ ++ + Y L
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1288
Query: 287 YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 341
Y+A QL P++ P + + + G + + +D +Y ++L+S + +
Sbjct: 1289 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340
Query: 342 -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 394
+ A + L+ + ++ L + + + +A +
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400
Query: 395 LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 438
++ E V A ++ S + EA++++ RQA + LR +
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 439 RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 492
+++ G + + R + EE R ++E ERL RQ + E+ AE
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520
Query: 493 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
+ + Q+ + LE+L+L EE+ E L + + +L A ++ L
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 553 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
ASF E + L R S + ++++ E E+R+Q
Sbjct: 1579 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1615
Query: 613 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
+ A E R EE +++++ + +E+ R L ++ + ++ E K+KE
Sbjct: 1616 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1667
Query: 673 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
+ R+ + E+ V ++ L+ + + E + RL E+E + +
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1721
Query: 733 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 788
E E QR ++ +E+++ L+++A Q+ Q + K + + ++L + E+E+
Sbjct: 1722 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 789 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 846
EK L G L E + + E L+ + + A+A+ V
Sbjct: 1780 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836
Query: 847 EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 877
E A+ +A + + E+ R LEE+ QHK +
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896
Query: 878 ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 918
+ DTL +++ ++ F A G++ + L LG+ S
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1953
Query: 919 CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 969
+ L + E RR Q S +++ + A E
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 970 LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1029
L + +++A +S+ ++ + A + + + ++ +++ E+ L+Q
Sbjct: 2014 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 1030 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1083
++ +L+ E EA +RA EE + RE + R Q E ++R K E++ + R
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128
Query: 1084 ERQRAQARPLTR 1095
+ +A A L +
Sbjct: 2129 AQAQAAAEKLRK 2140
Score = 45.1 bits (105), Expect = 4e-04
Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)
Query: 401 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 460
+ + A + +F + E +LE R S + ++ + + R + RR+R
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1984
Query: 461 EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 520
E R Q+ SL AE R + +E+V+++ ++E+ + E +
Sbjct: 1985 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2028
Query: 521 VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 580
E A + ++ L + A ++ Q ++ + ++ + D R
Sbjct: 2029 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2081
Query: 581 PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 638
+ +A+ E+ + + S Q ++ L E + + +K++
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 639 NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 698
+Q E+ R E A L +Q ++ E+ K K+ + R+ A++E+ + +
Sbjct: 2142 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2192
Query: 699 LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 758
L+ ++ +H+ L +E+ Q+L E E R +E++ +++ Q
Sbjct: 2193 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 759 IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 814
+ + +A+ E ++ +++K+N LQ E E + + ++ + LS L E
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299
Query: 815 YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 863
++ + E + +T L + +A E A + + Q +
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359
Query: 864 ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 917
R+LE +++ E ++ L K + +S + A K +G+
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 918 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 971
+ + + E +R ++ +++ E + + E+ + +
Sbjct: 2418 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2477
Query: 972 SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 1021
+ + QA L DS+ + + D ++ A EE
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2533
Query: 1022 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1081
+R +Q E+ RL+ S E + A E +R++E L++ Q+ Q + L E+ +
Sbjct: 2534 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593
Query: 1082 IRER 1085
+RE+
Sbjct: 2594 LREQ 2597
Score = 41.6 bits (96), Expect = 0.005
Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)
Query: 419 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 474
EA+L+S R AS + A ER ++ + RR ++ ER RE+ LER
Sbjct: 1575 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Query: 475 QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 530
+L+ L L AE L+ + ++ +E + ++E++V + L +
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Query: 531 TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 589
+ + LA+ L + A T + + +LL + L R ++ K
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1751
Query: 590 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 649
+ L+ + E + + E EE+R + E+ KQ+++ + FREL
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1799
Query: 650 DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 708
E A L ++ E +++++ + R+ AE E+ + + + ++++
Sbjct: 1800 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
Query: 709 LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 766
L+ ++ E+E RL E++ ++L + A+++ +I +E+++ L+K ++ +++ +
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1912
Query: 767 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 826
+ ++++ + +E + L+ + + GK E + + I
Sbjct: 1913 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1956
Query: 827 NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 885
++ + A +A E ++ + ++ + EE +Q K L + L
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016
Query: 886 KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 945
K + + R + + Q + A K+ E ++ L+
Sbjct: 2017 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2072
Query: 946 QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 1005
Q + + R ++E R A E+ + ++ A ++ ++ ++ S +
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126
Query: 1006 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1055
+ + + E+L K+A E R ++ + EME K+ E+
Sbjct: 2127 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 1056 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1108
R++ +E+ L EET ++ L+++E+ +R +A+A R V +E F +R
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2235
Query: 1109 HVE 1111
+E
Sbjct: 2236 QME 2238
Score = 34.3 bits (77), Expect = 0.76
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)
Query: 1020 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1066
+E+E L + AE LL S+ R E + E+ K+R RE+ E + L
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810
Query: 1067 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1113
EE ++++L E++ RQRA+A R L L E L++ E A
Sbjct: 1811 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 54.3 bits (129), Expect = 7e-07
Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)
Query: 416 EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 474
E E +LE RQ A GT Q L + I + + + +++ +L E+E+ RL+R
Sbjct: 1656 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1709
Query: 475 Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 527
+ R E L + + L++ E+ + E K +L E F E L
Sbjct: 1710 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1768
Query: 528 SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 585
R R +++ LA + Q + + ++L + + TR
Sbjct: 1769 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1824
Query: 586 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 645
+ +E+ L L + + + +R +E AA + ++EE +++ +D E
Sbjct: 1825 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1876
Query: 646 FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 704
+ L +E L Q E E++ K + AELE + ++ D L E
Sbjct: 1877 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1933
Query: 705 HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 760
E +QL E E R E +E + + L E A ++ + E++ A ++A +
Sbjct: 1934 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 1993
Query: 761 QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
++A++E ++ EK + + Q+E+E L+++ S L +G
Sbjct: 1994 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2053
Query: 808 PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 865
E V E + + + + A+ A A A A++ KE +
Sbjct: 2054 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2113
Query: 866 LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 922
R + + L +D K + A + + +T L L +++ ++
Sbjct: 2114 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2172
Query: 923 LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 979
L L + ++ R +++ Q E R +E+ +
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232
Query: 980 YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1035
+ + + + + ++ S++A + + ++A+ + E++LK QA E TR
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292
Query: 1036 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1079
L E + K+ A E+ +R +E E+ +L EET Q+ +E E
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352
Query: 1080 --VKIRERQRAQAR 1091
+++ E RAQAR
Sbjct: 2353 LKLRVAEMSRAQAR 2366
Score = 48.5 bits (114), Expect = 4e-05
Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)
Query: 600 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
K E I E+ ELA E ++ ++ LE +Q+ +++ E+ EL+ E L E
Sbjct: 2376 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2433
Query: 660 QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 704
K SE + ++++++L L+ K + + E+ I EK K L E
Sbjct: 2434 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2493
Query: 705 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
+ L +Q + ++++E+ Q+L+ + E +R +E + +++ + QQ +
Sbjct: 2494 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2548
Query: 765 REQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
R+Q+ + E+N QR +E L LE+++
Sbjct: 2549 RQQEELLAEEN------QRLREQLQLLEEQH 2573
Score = 45.1 bits (105), Expect = 4e-04
Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)
Query: 227 SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 286
+MP + QA + ++ AL ++ RH E E ++++ ++ + Y L
Sbjct: 1203 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1256
Query: 287 YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 341
Y+A QL P++ P + + + G + + +D +Y ++L+S + +
Sbjct: 1257 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1308
Query: 342 -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 394
+ A + L+ + ++ L + + + +A +
Sbjct: 1309 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1368
Query: 395 LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 438
++ E V A ++ S + EA++++ RQA + LR +
Sbjct: 1369 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428
Query: 439 RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 492
+++ G + + R + EE R ++E ERL RQ + E+ AE
Sbjct: 1429 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1488
Query: 493 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
+ + Q+ + LE+L+L EE+ E L + + +L A ++ L
Sbjct: 1489 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1546
Query: 553 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
ASF E + L R S + ++++ E E+R+Q
Sbjct: 1547 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1583
Query: 613 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
+ A E R EE +++++ + +E+ R L ++ + ++ E K+KE
Sbjct: 1584 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1635
Query: 673 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
+ R+ + E+ V ++ L+ + + E + RL E+E + +
Sbjct: 1636 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1689
Query: 733 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 788
E E QR ++ +E+++ L+++A Q+ Q + K + + ++L + E+E+
Sbjct: 1690 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747
Query: 789 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 846
EK L G L E + + E L+ + + A+A+ V
Sbjct: 1748 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1804
Query: 847 EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 877
E A+ +A + + E+ R LEE+ QHK +
Sbjct: 1805 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1864
Query: 878 ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 918
+ DTL +++ ++ F A G++ + L LG+ S
Sbjct: 1865 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1921
Query: 919 CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 969
+ L + E RR Q S +++ + A E
Sbjct: 1922 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1981
Query: 970 LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1029
L + +++A +S+ ++ + A + + + ++ +++ E+ L+Q
Sbjct: 1982 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2036
Query: 1030 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1083
++ +L+ E EA +RA EE + RE + R Q E ++R K E++ + R
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2096
Query: 1084 ERQRAQARPLTR 1095
+ +A A L +
Sbjct: 2097 AQAQAAAEKLRK 2108
Score = 45.1 bits (105), Expect = 4e-04
Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)
Query: 401 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 460
+ + A + +F + E +LE R S + ++ + + R + RR+R
Sbjct: 1893 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1952
Query: 461 EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 520
E R Q+ SL AE R + +E+V+++ ++E+ + E +
Sbjct: 1953 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 1996
Query: 521 VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 580
E A + ++ L + A ++ Q ++ + ++ + D R
Sbjct: 1997 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2049
Query: 581 PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 638
+ +A+ E+ + + S Q ++ L E + + +K++
Sbjct: 2050 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2109
Query: 639 NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 698
+Q E+ R E A L +Q ++ E+ K K+ + R+ A++E+ + +
Sbjct: 2110 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2160
Query: 699 LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 758
L+ ++ +H+ L +E+ Q+L E E R +E++ +++ Q
Sbjct: 2161 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207
Query: 759 IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 814
+ + +A+ E ++ +++K+N LQ E E + + ++ + LS L E
Sbjct: 2208 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2267
Query: 815 YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 863
++ + E + +T L + +A E A + + Q +
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2327
Query: 864 ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 917
R+LE +++ E ++ L K + +S + A K +G+
Sbjct: 2328 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2385
Query: 918 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 971
+ + + E +R ++ +++ E + + E+ + +
Sbjct: 2386 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2445
Query: 972 SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 1021
+ + QA L DS+ + + D ++ A EE
Sbjct: 2446 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2501
Query: 1022 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1081
+R +Q E+ RL+ S E + A E +R++E L++ Q+ Q + L E+ +
Sbjct: 2502 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2561
Query: 1082 IRER 1085
+RE+
Sbjct: 2562 LREQ 2565
Score = 41.6 bits (96), Expect = 0.005
Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)
Query: 419 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 474
EA+L+S R AS + A ER ++ + RR ++ ER RE+ LER
Sbjct: 1543 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601
Query: 475 QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 530
+L+ L L AE L+ + ++ +E + ++E++V + L +
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1661
Query: 531 TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 589
+ + LA+ L + A T + + +LL + L R ++ K
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1719
Query: 590 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 649
+ L+ + E + + E EE+R + E+ KQ+++ + FREL
Sbjct: 1720 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1767
Query: 650 DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 708
E A L ++ E +++++ + R+ AE E+ + + + ++++
Sbjct: 1768 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1823
Query: 709 LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 766
L+ ++ E+E RL E++ ++L + A+++ +I +E+++ L+K ++ +++ +
Sbjct: 1824 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1880
Query: 767 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 826
+ ++++ + +E + L+ + + GK E + + I
Sbjct: 1881 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1924
Query: 827 NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 885
++ + A +A E ++ + ++ + EE +Q K L + L
Sbjct: 1925 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1984
Query: 886 KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 945
K + + R + + Q + A K+ E ++ L+
Sbjct: 1985 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2040
Query: 946 QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 1005
Q + + R ++E R A E+ + ++ A ++ ++ ++ S +
Sbjct: 2041 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2094
Query: 1006 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1055
+ + + E+L K+A E R ++ + EME K+ E+
Sbjct: 2095 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146
Query: 1056 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1108
R++ +E+ L EET ++ L+++E+ +R +A+A R V +E F +R
Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2203
Query: 1109 HVE 1111
+E
Sbjct: 2204 QME 2206
Score = 34.3 bits (77), Expect = 0.76
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)
Query: 1020 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1066
+E+E L + AE LL S+ R E + E+ K+R RE+ E + L
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1778
Query: 1067 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1113
EE ++++L E++ RQRA+A R L L E L++ E A
Sbjct: 1779 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1823
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 54.3 bits (129), Expect = 7e-07
Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)
Query: 416 EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 474
E E +LE RQ A GT Q L + I + + + +++ +L E+E+ RL+R
Sbjct: 1825 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1878
Query: 475 Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 527
+ R E L + + L++ E+ + E K +L E F E L
Sbjct: 1879 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1937
Query: 528 SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 585
R R +++ LA + Q + + ++L + + TR
Sbjct: 1938 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1993
Query: 586 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 645
+ +E+ L L + + + +R +E AA + ++EE +++ +D E
Sbjct: 1994 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 2045
Query: 646 FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 704
+ L +E L Q E E++ K + AELE + ++ D L E
Sbjct: 2046 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 2102
Query: 705 HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 760
E +QL E E R E +E + + L E A ++ + E++ A ++A +
Sbjct: 2103 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2162
Query: 761 QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
++A++E ++ EK + + Q+E+E L+++ S L +G
Sbjct: 2163 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2222
Query: 808 PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 865
E V E + + + + A+ A A A A++ KE +
Sbjct: 2223 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2282
Query: 866 LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 922
R + + L +D K + A + + +T L L +++ ++
Sbjct: 2283 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2341
Query: 923 LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 979
L L + ++ R +++ Q E R +E+ +
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401
Query: 980 YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1035
+ + + + + ++ S++A + + ++A+ + E++LK QA E TR
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461
Query: 1036 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1079
L E + K+ A E+ +R +E E+ +L EET Q+ +E E
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521
Query: 1080 --VKIRERQRAQAR 1091
+++ E RAQAR
Sbjct: 2522 LKLRVAEMSRAQAR 2535
Score = 48.5 bits (114), Expect = 4e-05
Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)
Query: 600 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
K E I E+ ELA E ++ ++ LE +Q+ +++ E+ EL+ E L E
Sbjct: 2545 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2602
Query: 660 QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 704
K SE + ++++++L L+ K + + E+ I EK K L E
Sbjct: 2603 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2662
Query: 705 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
+ L +Q + ++++E+ Q+L+ + E +R +E + +++ + QQ +
Sbjct: 2663 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2717
Query: 765 REQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
R+Q+ + E+N QR +E L LE+++
Sbjct: 2718 RQQEELLAEEN------QRLREQLQLLEEQH 2742
Score = 45.1 bits (105), Expect = 4e-04
Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)
Query: 227 SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 286
+MP + QA + ++ AL ++ RH E E ++++ ++ + Y L
Sbjct: 1372 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1425
Query: 287 YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 341
Y+A QL P++ P + + + G + + +D +Y ++L+S + +
Sbjct: 1426 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1477
Query: 342 -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 394
+ A + L+ + ++ L + + + +A +
Sbjct: 1478 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1537
Query: 395 LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 438
++ E V A ++ S + EA++++ RQA + LR +
Sbjct: 1538 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1597
Query: 439 RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 492
+++ G + + R + EE R ++E ERL RQ + E+ AE
Sbjct: 1598 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1657
Query: 493 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
+ + Q+ + LE+L+L EE+ E L + + +L A ++ L
Sbjct: 1658 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1715
Query: 553 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
ASF E + L R S + ++++ E E+R+Q
Sbjct: 1716 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1752
Query: 613 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
+ A E R EE +++++ + +E+ R L ++ + ++ E K+KE
Sbjct: 1753 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1804
Query: 673 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
+ R+ + E+ V ++ L+ + + E + RL E+E + +
Sbjct: 1805 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1858
Query: 733 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 788
E E QR ++ +E+++ L+++A Q+ Q + K + + ++L + E+E+
Sbjct: 1859 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916
Query: 789 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 846
EK L G L E + + E L+ + + A+A+ V
Sbjct: 1917 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1973
Query: 847 EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 877
E A+ +A + + E+ R LEE+ QHK +
Sbjct: 1974 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 2033
Query: 878 ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 918
+ DTL +++ ++ F A G++ + L LG+ S
Sbjct: 2034 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 2090
Query: 919 CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 969
+ L + E RR Q S +++ + A E
Sbjct: 2091 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150
Query: 970 LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1029
L + +++A +S+ ++ + A + + + ++ +++ E+ L+Q
Sbjct: 2151 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2205
Query: 1030 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1083
++ +L+ E EA +RA EE + RE + R Q E ++R K E++ + R
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2265
Query: 1084 ERQRAQARPLTR 1095
+ +A A L +
Sbjct: 2266 AQAQAAAEKLRK 2277
Score = 45.1 bits (105), Expect = 4e-04
Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)
Query: 401 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 460
+ + A + +F + E +LE R S + ++ + + R + RR+R
Sbjct: 2062 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 2121
Query: 461 EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 520
E R Q+ SL AE R + +E+V+++ ++E+ + E +
Sbjct: 2122 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2165
Query: 521 VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 580
E A + ++ L + A ++ Q ++ + ++ + D R
Sbjct: 2166 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2218
Query: 581 PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 638
+ +A+ E+ + + S Q ++ L E + + +K++
Sbjct: 2219 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2278
Query: 639 NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 698
+Q E+ R E A L +Q ++ E+ K K+ + R+ A++E+ + +
Sbjct: 2279 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2329
Query: 699 LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 758
L+ ++ +H+ L +E+ Q+L E E R +E++ +++ Q
Sbjct: 2330 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376
Query: 759 IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 814
+ + +A+ E ++ +++K+N LQ E E + + ++ + LS L E
Sbjct: 2377 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2436
Query: 815 YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 863
++ + E + +T L + +A E A + + Q +
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2496
Query: 864 ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 917
R+LE +++ E ++ L K + +S + A K +G+
Sbjct: 2497 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2554
Query: 918 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 971
+ + + E +R ++ +++ E + + E+ + +
Sbjct: 2555 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2614
Query: 972 SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 1021
+ + QA L DS+ + + D ++ A EE
Sbjct: 2615 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2670
Query: 1022 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1081
+R +Q E+ RL+ S E + A E +R++E L++ Q+ Q + L E+ +
Sbjct: 2671 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2730
Query: 1082 IRER 1085
+RE+
Sbjct: 2731 LREQ 2734
Score = 41.6 bits (96), Expect = 0.005
Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)
Query: 419 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 474
EA+L+S R AS + A ER ++ + RR ++ ER RE+ LER
Sbjct: 1712 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770
Query: 475 QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 530
+L+ L L AE L+ + ++ +E + ++E++V + L +
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830
Query: 531 TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 589
+ + LA+ L + A T + + +LL + L R ++ K
Sbjct: 1831 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1888
Query: 590 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 649
+ L+ + E + + E EE+R + E+ KQ+++ + FREL
Sbjct: 1889 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1936
Query: 650 DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 708
E A L ++ E +++++ + R+ AE E+ + + + ++++
Sbjct: 1937 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1992
Query: 709 LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 766
L+ ++ E+E RL E++ ++L + A+++ +I +E+++ L+K ++ +++ +
Sbjct: 1993 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 2049
Query: 767 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 826
+ ++++ + +E + L+ + + GK E + + I
Sbjct: 2050 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 2093
Query: 827 NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 885
++ + A +A E ++ + ++ + EE +Q K L + L
Sbjct: 2094 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2153
Query: 886 KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 945
K + + R + + Q + A K+ E ++ L+
Sbjct: 2154 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2209
Query: 946 QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 1005
Q + + R ++E R A E+ + ++ A ++ ++ ++ S +
Sbjct: 2210 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2263
Query: 1006 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1055
+ + + E+L K+A E R ++ + EME K+ E+
Sbjct: 2264 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315
Query: 1056 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1108
R++ +E+ L EET ++ L+++E+ +R +A+A R V +E F +R
Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2372
Query: 1109 HVE 1111
+E
Sbjct: 2373 QME 2375
Score = 34.3 bits (77), Expect = 0.76
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)
Query: 1020 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1066
+E+E L + AE LL S+ R E + E+ K+R RE+ E + L
Sbjct: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1947
Query: 1067 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1113
EE ++++L E++ RQRA+A R L L E L++ E A
Sbjct: 1948 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1992
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 54.3 bits (129), Expect = 7e-07
Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)
Query: 416 EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 474
E E +LE RQ A GT Q L + I + + + +++ +L E+E+ RL+R
Sbjct: 1666 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1719
Query: 475 Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 527
+ R E L + + L++ E+ + E K +L E F E L
Sbjct: 1720 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1778
Query: 528 SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 585
R R +++ LA + Q + + ++L + + TR
Sbjct: 1779 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1834
Query: 586 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 645
+ +E+ L L + + + +R +E AA + ++EE +++ +D E
Sbjct: 1835 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1886
Query: 646 FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 704
+ L +E L Q E E++ K + AELE + ++ D L E
Sbjct: 1887 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1943
Query: 705 HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 760
E +QL E E R E +E + + L E A ++ + E++ A ++A +
Sbjct: 1944 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2003
Query: 761 QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
++A++E ++ EK + + Q+E+E L+++ S L +G
Sbjct: 2004 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2063
Query: 808 PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 865
E V E + + + + A+ A A A A++ KE +
Sbjct: 2064 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2123
Query: 866 LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 922
R + + L +D K + A + + +T L L +++ ++
Sbjct: 2124 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2182
Query: 923 LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 979
L L + ++ R +++ Q E R +E+ +
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
Query: 980 YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1035
+ + + + + ++ S++A + + ++A+ + E++LK QA E TR
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302
Query: 1036 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1079
L E + K+ A E+ +R +E E+ +L EET Q+ +E E
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362
Query: 1080 --VKIRERQRAQAR 1091
+++ E RAQAR
Sbjct: 2363 LKLRVAEMSRAQAR 2376
Score = 48.5 bits (114), Expect = 4e-05
Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)
Query: 600 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
K E I E+ ELA E ++ ++ LE +Q+ +++ E+ EL+ E L E
Sbjct: 2386 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2443
Query: 660 QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 704
K SE + ++++++L L+ K + + E+ I EK K L E
Sbjct: 2444 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2503
Query: 705 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
+ L +Q + ++++E+ Q+L+ + E +R +E + +++ + QQ +
Sbjct: 2504 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2558
Query: 765 REQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
R+Q+ + E+N QR +E L LE+++
Sbjct: 2559 RQQEELLAEEN------QRLREQLQLLEEQH 2583
Score = 45.1 bits (105), Expect = 4e-04
Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)
Query: 227 SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 286
+MP + QA + ++ AL ++ RH E E ++++ ++ + Y L
Sbjct: 1213 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1266
Query: 287 YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 341
Y+A QL P++ P + + + G + + +D +Y ++L+S + +
Sbjct: 1267 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1318
Query: 342 -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 394
+ A + L+ + ++ L + + + +A +
Sbjct: 1319 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1378
Query: 395 LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 438
++ E V A ++ S + EA++++ RQA + LR +
Sbjct: 1379 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1438
Query: 439 RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 492
+++ G + + R + EE R ++E ERL RQ + E+ AE
Sbjct: 1439 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1498
Query: 493 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
+ + Q+ + LE+L+L EE+ E L + + +L A ++ L
Sbjct: 1499 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1556
Query: 553 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
ASF E + L R S + ++++ E E+R+Q
Sbjct: 1557 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1593
Query: 613 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
+ A E R EE +++++ + +E+ R L ++ + ++ E K+KE
Sbjct: 1594 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1645
Query: 673 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
+ R+ + E+ V ++ L+ + + E + RL E+E + +
Sbjct: 1646 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1699
Query: 733 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 788
E E QR ++ +E+++ L+++A Q+ Q + K + + ++L + E+E+
Sbjct: 1700 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757
Query: 789 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 846
EK L G L E + + E L+ + + A+A+ V
Sbjct: 1758 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1814
Query: 847 EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 877
E A+ +A + + E+ R LEE+ QHK +
Sbjct: 1815 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1874
Query: 878 ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 918
+ DTL +++ ++ F A G++ + L LG+ S
Sbjct: 1875 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1931
Query: 919 CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 969
+ L + E RR Q S +++ + A E
Sbjct: 1932 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991
Query: 970 LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1029
L + +++A +S+ ++ + A + + + ++ +++ E+ L+Q
Sbjct: 1992 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2046
Query: 1030 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1083
++ +L+ E EA +RA EE + RE + R Q E ++R K E++ + R
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2106
Query: 1084 ERQRAQARPLTR 1095
+ +A A L +
Sbjct: 2107 AQAQAAAEKLRK 2118
Score = 45.1 bits (105), Expect = 4e-04
Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)
Query: 401 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 460
+ + A + +F + E +LE R S + ++ + + R + RR+R
Sbjct: 1903 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1962
Query: 461 EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 520
E R Q+ SL AE R + +E+V+++ ++E+ + E +
Sbjct: 1963 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2006
Query: 521 VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 580
E A + ++ L + A ++ Q ++ + ++ + D R
Sbjct: 2007 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2059
Query: 581 PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 638
+ +A+ E+ + + S Q ++ L E + + +K++
Sbjct: 2060 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2119
Query: 639 NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 698
+Q E+ R E A L +Q ++ E+ K K+ + R+ A++E+ + +
Sbjct: 2120 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2170
Query: 699 LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 758
L+ ++ +H+ L +E+ Q+L E E R +E++ +++ Q
Sbjct: 2171 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217
Query: 759 IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 814
+ + +A+ E ++ +++K+N LQ E E + + ++ + LS L E
Sbjct: 2218 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2277
Query: 815 YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 863
++ + E + +T L + +A E A + + Q +
Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2337
Query: 864 ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 917
R+LE +++ E ++ L K + +S + A K +G+
Sbjct: 2338 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2395
Query: 918 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 971
+ + + E +R ++ +++ E + + E+ + +
Sbjct: 2396 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2455
Query: 972 SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 1021
+ + QA L DS+ + + D ++ A EE
Sbjct: 2456 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2511
Query: 1022 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1081
+R +Q E+ RL+ S E + A E +R++E L++ Q+ Q + L E+ +
Sbjct: 2512 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2571
Query: 1082 IRER 1085
+RE+
Sbjct: 2572 LREQ 2575
Score = 41.6 bits (96), Expect = 0.005
Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)
Query: 419 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 474
EA+L+S R AS + A ER ++ + RR ++ ER RE+ LER
Sbjct: 1553 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611
Query: 475 QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 530
+L+ L L AE L+ + ++ +E + ++E++V + L +
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671
Query: 531 TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 589
+ + LA+ L + A T + + +LL + L R ++ K
Sbjct: 1672 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1729
Query: 590 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 649
+ L+ + E + + E EE+R + E+ KQ+++ + FREL
Sbjct: 1730 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1777
Query: 650 DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 708
E A L ++ E +++++ + R+ AE E+ + + + ++++
Sbjct: 1778 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1833
Query: 709 LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 766
L+ ++ E+E RL E++ ++L + A+++ +I +E+++ L+K ++ +++ +
Sbjct: 1834 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1890
Query: 767 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 826
+ ++++ + +E + L+ + + GK E + + I
Sbjct: 1891 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1934
Query: 827 NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 885
++ + A +A E ++ + ++ + EE +Q K L + L
Sbjct: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1994
Query: 886 KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 945
K + + R + + Q + A K+ E ++ L+
Sbjct: 1995 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2050
Query: 946 QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 1005
Q + + R ++E R A E+ + ++ A ++ ++ ++ S +
Sbjct: 2051 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2104
Query: 1006 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1055
+ + + E+L K+A E R ++ + EME K+ E+
Sbjct: 2105 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156
Query: 1056 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1108
R++ +E+ L EET ++ L+++E+ +R +A+A R V +E F +R
Sbjct: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2213
Query: 1109 HVE 1111
+E
Sbjct: 2214 QME 2216
Score = 34.3 bits (77), Expect = 0.76
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)
Query: 1020 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1066
+E+E L + AE LL S+ R E + E+ K+R RE+ E + L
Sbjct: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1788
Query: 1067 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1113
EE ++++L E++ RQRA+A R L L E L++ E A
Sbjct: 1789 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1833
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 54.3 bits (129), Expect = 7e-07
Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)
Query: 416 EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 474
E E +LE RQ A GT Q L + I + + + +++ +L E+E+ RL+R
Sbjct: 1674 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1727
Query: 475 Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 527
+ R E L + + L++ E+ + E K +L E F E L
Sbjct: 1728 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1786
Query: 528 SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 585
R R +++ LA + Q + + ++L + + TR
Sbjct: 1787 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1842
Query: 586 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 645
+ +E+ L L + + + +R +E AA + ++EE +++ +D E
Sbjct: 1843 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1894
Query: 646 FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 704
+ L +E L Q E E++ K + AELE + ++ D L E
Sbjct: 1895 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1951
Query: 705 HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 760
E +QL E E R E +E + + L E A ++ + E++ A ++A +
Sbjct: 1952 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2011
Query: 761 QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
++A++E ++ EK + + Q+E+E L+++ S L +G
Sbjct: 2012 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2071
Query: 808 PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 865
E V E + + + + A+ A A A A++ KE +
Sbjct: 2072 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2131
Query: 866 LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 922
R + + L +D K + A + + +T L L +++ ++
Sbjct: 2132 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2190
Query: 923 LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 979
L L + ++ R +++ Q E R +E+ +
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250
Query: 980 YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1035
+ + + + + ++ S++A + + ++A+ + E++LK QA E TR
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310
Query: 1036 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1079
L E + K+ A E+ +R +E E+ +L EET Q+ +E E
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370
Query: 1080 --VKIRERQRAQAR 1091
+++ E RAQAR
Sbjct: 2371 LKLRVAEMSRAQAR 2384
Score = 48.5 bits (114), Expect = 4e-05
Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)
Query: 600 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
K E I E+ ELA E ++ ++ LE +Q+ +++ E+ EL+ E L E
Sbjct: 2394 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2451
Query: 660 QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 704
K SE + ++++++L L+ K + + E+ I EK K L E
Sbjct: 2452 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2511
Query: 705 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
+ L +Q + ++++E+ Q+L+ + E +R +E + +++ + QQ +
Sbjct: 2512 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2566
Query: 765 REQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
R+Q+ + E+N QR +E L LE+++
Sbjct: 2567 RQQEELLAEEN------QRLREQLQLLEEQH 2591
Score = 45.1 bits (105), Expect = 4e-04
Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)
Query: 227 SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 286
+MP + QA + ++ AL ++ RH E E ++++ ++ + Y L
Sbjct: 1221 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1274
Query: 287 YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 341
Y+A QL P++ P + + + G + + +D +Y ++L+S + +
Sbjct: 1275 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1326
Query: 342 -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 394
+ A + L+ + ++ L + + + +A +
Sbjct: 1327 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1386
Query: 395 LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 438
++ E V A ++ S + EA++++ RQA + LR +
Sbjct: 1387 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1446
Query: 439 RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 492
+++ G + + R + EE R ++E ERL RQ + E+ AE
Sbjct: 1447 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1506
Query: 493 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
+ + Q+ + LE+L+L EE+ E L + + +L A ++ L
Sbjct: 1507 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1564
Query: 553 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
ASF E + L R S + ++++ E E+R+Q
Sbjct: 1565 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1601
Query: 613 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
+ A E R EE +++++ + +E+ R L ++ + ++ E K+KE
Sbjct: 1602 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1653
Query: 673 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
+ R+ + E+ V ++ L+ + + E + RL E+E + +
Sbjct: 1654 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1707
Query: 733 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 788
E E QR ++ +E+++ L+++A Q+ Q + K + + ++L + E+E+
Sbjct: 1708 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765
Query: 789 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 846
EK L G L E + + E L+ + + A+A+ V
Sbjct: 1766 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1822
Query: 847 EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 877
E A+ +A + + E+ R LEE+ QHK +
Sbjct: 1823 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1882
Query: 878 ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 918
+ DTL +++ ++ F A G++ + L LG+ S
Sbjct: 1883 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1939
Query: 919 CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 969
+ L + E RR Q S +++ + A E
Sbjct: 1940 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1999
Query: 970 LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1029
L + +++A +S+ ++ + A + + + ++ +++ E+ L+Q
Sbjct: 2000 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2054
Query: 1030 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1083
++ +L+ E EA +RA EE + RE + R Q E ++R K E++ + R
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2114
Query: 1084 ERQRAQARPLTR 1095
+ +A A L +
Sbjct: 2115 AQAQAAAEKLRK 2126
Score = 45.1 bits (105), Expect = 4e-04
Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)
Query: 401 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 460
+ + A + +F + E +LE R S + ++ + + R + RR+R
Sbjct: 1911 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1970
Query: 461 EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 520
E R Q+ SL AE R + +E+V+++ ++E+ + E +
Sbjct: 1971 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2014
Query: 521 VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 580
E A + ++ L + A ++ Q ++ + ++ + D R
Sbjct: 2015 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2067
Query: 581 PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 638
+ +A+ E+ + + S Q ++ L E + + +K++
Sbjct: 2068 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2127
Query: 639 NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 698
+Q E+ R E A L +Q ++ E+ K K+ + R+ A++E+ + +
Sbjct: 2128 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2178
Query: 699 LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 758
L+ ++ +H+ L +E+ Q+L E E R +E++ +++ Q
Sbjct: 2179 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2225
Query: 759 IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 814
+ + +A+ E ++ +++K+N LQ E E + + ++ + LS L E
Sbjct: 2226 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2285
Query: 815 YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 863
++ + E + +T L + +A E A + + Q +
Sbjct: 2286 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2345
Query: 864 ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 917
R+LE +++ E ++ L K + +S + A K +G+
Sbjct: 2346 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2403
Query: 918 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 971
+ + + E +R ++ +++ E + + E+ + +
Sbjct: 2404 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2463
Query: 972 SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 1021
+ + QA L DS+ + + D ++ A EE
Sbjct: 2464 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2519
Query: 1022 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1081
+R +Q E+ RL+ S E + A E +R++E L++ Q+ Q + L E+ +
Sbjct: 2520 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2579
Query: 1082 IRER 1085
+RE+
Sbjct: 2580 LREQ 2583
Score = 41.6 bits (96), Expect = 0.005
Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)
Query: 419 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 474
EA+L+S R AS + A ER ++ + RR ++ ER RE+ LER
Sbjct: 1561 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619
Query: 475 QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 530
+L+ L L AE L+ + ++ +E + ++E++V + L +
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1679
Query: 531 TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 589
+ + LA+ L + A T + + +LL + L R ++ K
Sbjct: 1680 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1737
Query: 590 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 649
+ L+ + E + + E EE+R + E+ KQ+++ + FREL
Sbjct: 1738 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1785
Query: 650 DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 708
E A L ++ E +++++ + R+ AE E+ + + + ++++
Sbjct: 1786 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1841
Query: 709 LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 766
L+ ++ E+E RL E++ ++L + A+++ +I +E+++ L+K ++ +++ +
Sbjct: 1842 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1898
Query: 767 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 826
+ ++++ + +E + L+ + + GK E + + I
Sbjct: 1899 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1942
Query: 827 NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 885
++ + A +A E ++ + ++ + EE +Q K L + L
Sbjct: 1943 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2002
Query: 886 KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 945
K + + R + + Q + A K+ E ++ L+
Sbjct: 2003 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2058
Query: 946 QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 1005
Q + + R ++E R A E+ + ++ A ++ ++ ++ S +
Sbjct: 2059 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2112
Query: 1006 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1055
+ + + E+L K+A E R ++ + EME K+ E+
Sbjct: 2113 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164
Query: 1056 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1108
R++ +E+ L EET ++ L+++E+ +R +A+A R V +E F +R
Sbjct: 2165 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2221
Query: 1109 HVE 1111
+E
Sbjct: 2222 QME 2224
Score = 34.3 bits (77), Expect = 0.76
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)
Query: 1020 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1066
+E+E L + AE LL S+ R E + E+ K+R RE+ E + L
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1796
Query: 1067 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1113
EE ++++L E++ RQRA+A R L L E L++ E A
Sbjct: 1797 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1841
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.348
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,136,678
Number of Sequences: 37866
Number of extensions: 2345914
Number of successful extensions: 21841
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 310
Number of HSP's successfully gapped in prelim test: 893
Number of HSP's that attempted gapping in prelim test: 12033
Number of HSP's gapped (non-prelim): 8072
length of query: 1237
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1123
effective length of database: 13,930,794
effective search space: 15644281662
effective search space used: 15644281662
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.