Guide to the Human Genome
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Search of human proteins with 197313728

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|197313728 pleckstrin homology-like domain, family B, member
2 isoform b [Homo sapiens]
         (1237 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|197313728 pleckstrin homology-like domain, family B, member 2...  2439   0.0  
gi|21955172 pleckstrin homology-like domain, family B, member 2 ...  2385   0.0  
gi|197313732 pleckstrin homology-like domain, family B, member 2...  2364   0.0  
gi|197313730 pleckstrin homology-like domain, family B, member 2...  2364   0.0  
gi|221219026 pleckstrin homology-like domain, family B, member 1...   657   0.0  
gi|221219024 pleckstrin homology-like domain, family B, member 1...   652   0.0  
gi|38424073 pleckstrin homology-like domain, family B, member 1 ...   652   0.0  
gi|157266264 pleckstrin homology-like domain, family B, member 3...   201   5e-51
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             67   8e-11
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    65   5e-10
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     62   3e-09
gi|41281453 serine/threonine kinase 2 [Homo sapiens]                   60   1e-08
gi|29788755 SET binding factor 2 [Homo sapiens]                        59   2e-08
gi|239735519 SET binding factor 1 [Homo sapiens]                       58   6e-08
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         57   8e-08
gi|4885583 Rho-associated, coiled-coil containing protein kinase...    57   1e-07
gi|38044112 restin isoform b [Homo sapiens]                            56   2e-07
gi|4506751 restin isoform a [Homo sapiens]                             56   2e-07
gi|21735548 centrosomal protein 2 [Homo sapiens]                       56   2e-07
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...    56   2e-07
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    55   3e-07
gi|118498356 kinectin 1 isoform a [Homo sapiens]                       55   4e-07
gi|33620775 kinectin 1 isoform a [Homo sapiens]                        55   4e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        54   7e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        54   7e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         54   7e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         54   7e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         54   7e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         54   7e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         54   7e-07

>gi|197313728 pleckstrin homology-like domain, family B, member 2
            isoform b [Homo sapiens]
          Length = 1237

 Score = 2439 bits (6321), Expect = 0.0
 Identities = 1237/1237 (100%), Positives = 1237/1237 (100%)

Query: 1    MEEEDTKREVPKEDGVGDVQHFDSSKIMEEHSYIQKELDLQNGSLEEDSVVHSVENDSQN 60
            MEEEDTKREVPKEDGVGDVQHFDSSKIMEEHSYIQKELDLQNGSLEEDSVVHSVENDSQN
Sbjct: 1    MEEEDTKREVPKEDGVGDVQHFDSSKIMEEHSYIQKELDLQNGSLEEDSVVHSVENDSQN 60

Query: 61   MMESLSPKKYSSSLRFKANGDYSGSYLTLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQ 120
            MMESLSPKKYSSSLRFKANGDYSGSYLTLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQ
Sbjct: 61   MMESLSPKKYSSSLRFKANGDYSGSYLTLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQ 120

Query: 121  FSYDGTDKNIPMKPPTPLLNTTSSLSGYPLGRADFDHYTGRDSERALRLSEKPPYSKYSS 180
            FSYDGTDKNIPMKPPTPLLNTTSSLSGYPLGRADFDHYTGRDSERALRLSEKPPYSKYSS
Sbjct: 121  FSYDGTDKNIPMKPPTPLLNTTSSLSGYPLGRADFDHYTGRDSERALRLSEKPPYSKYSS 180

Query: 181  RHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISRSGAASMPSSPKQARKMSI 240
            RHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISRSGAASMPSSPKQARKMSI
Sbjct: 181  RHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISRSGAASMPSSPKQARKMSI 240

Query: 241  QDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLP 300
            QDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLP
Sbjct: 241  QDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLP 300

Query: 301  PRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPA 360
            PRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPA
Sbjct: 301  PRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPA 360

Query: 361  SPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEA 420
            SPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEA
Sbjct: 361  SPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEA 420

Query: 421  DLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETI 480
            DLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETI
Sbjct: 421  DLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETI 480

Query: 481  LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDS 540
            LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDS
Sbjct: 481  LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDS 540

Query: 541  LPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPK 600
            LPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPK
Sbjct: 541  LPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPK 600

Query: 601  TPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ 660
            TPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ
Sbjct: 601  TPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ 660

Query: 661  KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRL 720
            KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRL
Sbjct: 661  KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRL 720

Query: 721  DEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMM 780
            DEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMM
Sbjct: 721  DEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMM 780

Query: 781  LQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPAD 840
            LQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPAD
Sbjct: 781  LQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPAD 840

Query: 841  ADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSAT 900
            ADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSAT
Sbjct: 841  ADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSAT 900

Query: 901  MGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN 960
            MGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN
Sbjct: 901  MGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN 960

Query: 961  RTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIE 1020
            RTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIE
Sbjct: 961  RTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIE 1020

Query: 1021 EMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEV 1080
            EMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEV
Sbjct: 1021 EMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEV 1080

Query: 1081 KIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMGGK 1140
            KIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMGGK
Sbjct: 1081 KIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMGGK 1140

Query: 1141 IKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFS 1200
            IKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFS
Sbjct: 1141 IKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFS 1200

Query: 1201 VKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1237
            VKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Sbjct: 1201 VKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1237


>gi|21955172 pleckstrin homology-like domain, family B, member 2
            isoform c [Homo sapiens]
          Length = 1210

 Score = 2385 bits (6180), Expect = 0.0
 Identities = 1210/1210 (100%), Positives = 1210/1210 (100%)

Query: 28   MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 87
            MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 1    MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60

Query: 88   TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 147
            TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 61   TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120

Query: 148  YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 207
            YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 121  YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180

Query: 208  NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 267
            NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 181  NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240

Query: 268  YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 327
            YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 241  YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300

Query: 328  YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 387
            YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 301  YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360

Query: 388  GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 447
            GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 361  GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420

Query: 448  GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 507
            GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 421  GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480

Query: 508  KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 567
            KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 481  KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540

Query: 568  DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 627
            DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 541  DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600

Query: 628  LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 687
            LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 601  LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660

Query: 688  IVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKE 747
            IVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKE
Sbjct: 661  IVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKE 720

Query: 748  KISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
            KISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN
Sbjct: 721  KISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 780

Query: 808  PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE 867
            PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE
Sbjct: 781  PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE 840

Query: 868  ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 927
            ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL
Sbjct: 841  ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 900

Query: 928  AAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDT 987
            AAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDT
Sbjct: 901  AAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDT 960

Query: 988  LSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAK 1047
            LSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAK
Sbjct: 961  LSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAK 1020

Query: 1048 KRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR 1107
            KRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR
Sbjct: 1021 KRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR 1080

Query: 1108 SHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHET 1167
            SHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHET
Sbjct: 1081 SHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHET 1140

Query: 1168 KLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVT 1227
            KLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVT
Sbjct: 1141 KLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVT 1200

Query: 1228 GAEGYTHFLL 1237
            GAEGYTHFLL
Sbjct: 1201 GAEGYTHFLL 1210


>gi|197313732 pleckstrin homology-like domain, family B, member 2
            isoform a [Homo sapiens]
          Length = 1253

 Score = 2364 bits (6126), Expect = 0.0
 Identities = 1210/1253 (96%), Positives = 1210/1253 (96%), Gaps = 43/1253 (3%)

Query: 28   MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 87
            MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 1    MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60

Query: 88   TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 147
            TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 61   TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120

Query: 148  YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 207
            YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 121  YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180

Query: 208  NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 267
            NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 181  NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240

Query: 268  YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 327
            YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 241  YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300

Query: 328  YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 387
            YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 301  YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360

Query: 388  GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 447
            GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 361  GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420

Query: 448  GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 507
            GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 421  GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480

Query: 508  KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 567
            KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 481  KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540

Query: 568  DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 627
            DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 541  DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600

Query: 628  LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 687
            LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 601  LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660

Query: 688  IVGEKTK-------------------------------------------DADLLDVESK 704
            IVGEKTK                                           DADLLDVESK
Sbjct: 661  IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720

Query: 705  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
            HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ
Sbjct: 721  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780

Query: 765  REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 824
            REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP
Sbjct: 781  REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840

Query: 825  CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 884
            CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP
Sbjct: 841  CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900

Query: 885  RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 944
            RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN
Sbjct: 901  RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960

Query: 945  HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1004
            HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS
Sbjct: 961  HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020

Query: 1005 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1064
            PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR
Sbjct: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080

Query: 1065 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1124
            LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS
Sbjct: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140

Query: 1125 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1184
            ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD
Sbjct: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200

Query: 1185 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1237
            HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Sbjct: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253


>gi|197313730 pleckstrin homology-like domain, family B, member 2
            isoform a [Homo sapiens]
          Length = 1253

 Score = 2364 bits (6126), Expect = 0.0
 Identities = 1210/1253 (96%), Positives = 1210/1253 (96%), Gaps = 43/1253 (3%)

Query: 28   MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 87
            MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 1    MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60

Query: 88   TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 147
            TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 61   TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120

Query: 148  YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 207
            YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 121  YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180

Query: 208  NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 267
            NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 181  NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240

Query: 268  YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 327
            YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 241  YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300

Query: 328  YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 387
            YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 301  YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360

Query: 388  GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 447
            GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 361  GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420

Query: 448  GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 507
            GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 421  GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480

Query: 508  KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 567
            KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 481  KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540

Query: 568  DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 627
            DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 541  DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600

Query: 628  LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 687
            LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 601  LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660

Query: 688  IVGEKTK-------------------------------------------DADLLDVESK 704
            IVGEKTK                                           DADLLDVESK
Sbjct: 661  IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720

Query: 705  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
            HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ
Sbjct: 721  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780

Query: 765  REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 824
            REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP
Sbjct: 781  REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840

Query: 825  CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 884
            CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP
Sbjct: 841  CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900

Query: 885  RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 944
            RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN
Sbjct: 901  RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960

Query: 945  HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1004
            HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS
Sbjct: 961  HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020

Query: 1005 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1064
            PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR
Sbjct: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080

Query: 1065 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1124
            LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS
Sbjct: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140

Query: 1125 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1184
            ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD
Sbjct: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200

Query: 1185 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1237
            HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Sbjct: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253


>gi|221219026 pleckstrin homology-like domain, family B, member 1
            isoform b [Homo sapiens]
          Length = 1319

 Score =  657 bits (1695), Expect = 0.0
 Identities = 390/838 (46%), Positives = 513/838 (61%), Gaps = 124/838 (14%)

Query: 434  PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 492
            P  RERK+SI+ IS   DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D 
Sbjct: 570  PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629

Query: 493  RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
                G    ++  I +    L L+                         P   LA     
Sbjct: 630  ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663

Query: 553  SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
            S       T R   + E  SD        SST    S++  +        E     +   
Sbjct: 664  SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711

Query: 613  ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
            E+ A+EE R  +L ++E+LK ++K++  Q+ ES RE +ME ALL GE+++E   L KE++
Sbjct: 712  EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQK 771

Query: 673  ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
             +D L  K+  LE  I  E+ K+A+ L+ E+K FEDLEFQQLE ESR++EE+E   Q LL
Sbjct: 772  AVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831

Query: 733  REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 792
            R  AE  R+I  RKE+++ L  QA  I  QA +E +   ++KN  + +LQ+EKE L  LE
Sbjct: 832  RSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLE 891

Query: 793  KKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAV 852
            ++Y SL+GG+ FP   +TLKE Y S  +     G +T+  P T+                
Sbjct: 892  RRYHSLTGGRPFPKTTSTLKEVYRSKMD-----GEATSPLPRTR---------------- 930

Query: 853  LASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLP 912
                                       S  LP    +SS S   S AT+GRS +PK+ L 
Sbjct: 931  ---------------------------SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALL 963

Query: 913  LGQSNSCGSVLPPSLAAMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVYL 970
                N  GS LP +LAA  +D E++R L  +    Q + E  R+ +E   + A+E+    
Sbjct: 964  T--QNGTGS-LPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW 1020

Query: 971  NSFH-----------YPD---HSYK-------------DQAFDTLSLDSSDSMETSIS-- 1001
            ++ H           +P    HS               + A+DTLSL+SSDSMETSIS  
Sbjct: 1021 DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG 1080

Query: 1002 ---ACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRR 1058
               ACSPDN+SSAS  ++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RRR
Sbjct: 1081 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR 1140

Query: 1059 EILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNID 1118
            E +E+RLQ E+++RQ+L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +D
Sbjct: 1141 EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD 1200

Query: 1119 TCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAI 1178
            TC HV ++ K CRG+L+KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQAI
Sbjct: 1201 TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI 1260

Query: 1179 EEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFL 1236
            EEVYYDHL++A KSPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIVTGAEGYT F+
Sbjct: 1261 EEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFM 1318


>gi|221219024 pleckstrin homology-like domain, family B, member 1
            isoform a [Homo sapiens]
          Length = 1377

 Score =  652 bits (1683), Expect = 0.0
 Identities = 392/850 (46%), Positives = 524/850 (61%), Gaps = 90/850 (10%)

Query: 434  PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 492
            P  RERK+SI+ IS   DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D 
Sbjct: 570  PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629

Query: 493  RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
                G    ++  I +    L L+                         P   LA     
Sbjct: 630  ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663

Query: 553  SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
            S       T R   + E  SD        SST    S++  +        E     +   
Sbjct: 664  SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711

Query: 613  ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
            E+ A+EE R  +L ++E+LK ++K++  Q+ ES RE +ME ALL GE+++E   L KE++
Sbjct: 712  EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQK 771

Query: 673  ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
             +D L  K+  LE  I  E+ K+A+ L+ E+K FEDLEFQQLE ESR++EE+E   Q LL
Sbjct: 772  AVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831

Query: 733  REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 792
            R  AE  R+I  RKE+++ L  QA  I  QA +E +   ++KN  + +LQ+EKE L  LE
Sbjct: 832  RSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLE 891

Query: 793  KKYSSLSGGKGFPVNPNTLKE-GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATA 851
            ++Y SL+GG+ FP   +TLKE   + +  ++        ++     PA A   ++ P   
Sbjct: 892  RRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLP 951

Query: 852  VLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHL 911
              AS+    + +RS  + +         S  LP    +SS S   S AT+GRS +PK+ L
Sbjct: 952  AKASR--QLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSAL 1009

Query: 912  PLGQSNSCGSVLPPSLAAMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVY 969
                 N  GS LP +LAA  +D E++R L  +    Q + E  R+ +E   + A+E+   
Sbjct: 1010 LT--QNGTGS-LPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQ 1066

Query: 970  LNSFH-----------YPD---HSYK-------------DQAFDTLSLDSSDSMETSIS- 1001
             ++ H           +P    HS               + A+DTLSL+SSDSMETSIS 
Sbjct: 1067 WDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSIST 1126

Query: 1002 ----ACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR 1057
                ACSPDN+SSAS  ++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RR
Sbjct: 1127 GGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRR 1186

Query: 1058 REILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNI 1117
            RE +E+RLQ E+++RQ+L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +
Sbjct: 1187 REQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGV 1246

Query: 1118 DTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQA 1177
            DTC HV ++ K CRG+L+KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQA
Sbjct: 1247 DTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQA 1306

Query: 1178 IEEVYYDHLKNANK-----------SPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIV 1226
            IEEVYYDHL++A K           SPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIV
Sbjct: 1307 IEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIV 1366

Query: 1227 TGAEGYTHFL 1236
            TGAEGYT F+
Sbjct: 1367 TGAEGYTQFM 1376


>gi|38424073 pleckstrin homology-like domain, family B, member 1
            isoform a [Homo sapiens]
          Length = 1377

 Score =  652 bits (1683), Expect = 0.0
 Identities = 392/850 (46%), Positives = 524/850 (61%), Gaps = 90/850 (10%)

Query: 434  PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 492
            P  RERK+SI+ IS   DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D 
Sbjct: 570  PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629

Query: 493  RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
                G    ++  I +    L L+                         P   LA     
Sbjct: 630  ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663

Query: 553  SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
            S       T R   + E  SD        SST    S++  +        E     +   
Sbjct: 664  SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711

Query: 613  ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
            E+ A+EE R  +L ++E+LK ++K++  Q+ ES RE +ME ALL GE+++E   L KE++
Sbjct: 712  EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQK 771

Query: 673  ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
             +D L  K+  LE  I  E+ K+A+ L+ E+K FEDLEFQQLE ESR++EE+E   Q LL
Sbjct: 772  AVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831

Query: 733  REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 792
            R  AE  R+I  RKE+++ L  QA  I  QA +E +   ++KN  + +LQ+EKE L  LE
Sbjct: 832  RSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLE 891

Query: 793  KKYSSLSGGKGFPVNPNTLKE-GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATA 851
            ++Y SL+GG+ FP   +TLKE   + +  ++        ++     PA A   ++ P   
Sbjct: 892  RRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLP 951

Query: 852  VLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHL 911
              AS+    + +RS  + +         S  LP    +SS S   S AT+GRS +PK+ L
Sbjct: 952  AKASR--QLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSAL 1009

Query: 912  PLGQSNSCGSVLPPSLAAMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVY 969
                 N  GS LP +LAA  +D E++R L  +    Q + E  R+ +E   + A+E+   
Sbjct: 1010 LT--QNGTGS-LPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQ 1066

Query: 970  LNSFH-----------YPD---HSYK-------------DQAFDTLSLDSSDSMETSIS- 1001
             ++ H           +P    HS               + A+DTLSL+SSDSMETSIS 
Sbjct: 1067 WDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSIST 1126

Query: 1002 ----ACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR 1057
                ACSPDN+SSAS  ++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RR
Sbjct: 1127 GGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRR 1186

Query: 1058 REILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNI 1117
            RE +E+RLQ E+++RQ+L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +
Sbjct: 1187 REQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGV 1246

Query: 1118 DTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQA 1177
            DTC HV ++ K CRG+L+KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQA
Sbjct: 1247 DTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQA 1306

Query: 1178 IEEVYYDHLKNANK-----------SPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIV 1226
            IEEVYYDHL++A K           SPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIV
Sbjct: 1307 IEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIV 1366

Query: 1227 TGAEGYTHFL 1236
            TGAEGYT F+
Sbjct: 1367 TGAEGYTQFM 1376


>gi|157266264 pleckstrin homology-like domain, family B, member 3
            [Homo sapiens]
          Length = 640

 Score =  201 bits (510), Expect = 5e-51
 Identities = 111/212 (52%), Positives = 130/212 (61%), Gaps = 31/212 (14%)

Query: 1019 IEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEK 1078
            I  MERLL+QA AE+ RLL++R    E  +R  E                          
Sbjct: 455  IAHMERLLQQAMAERERLLKAR----EGTRRGTEGSSG---------------------- 488

Query: 1079 EVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMG 1138
                     A   P T   P      DLR H+E  GHN + C HV ++   CRG L+KMG
Sbjct: 489  -----PAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMG 543

Query: 1139 GKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLT 1198
            G+IKTW+KRWF FDR  R  +YYADK ETKLKGVIYFQAIEEVYYDHL+ A KSPNP LT
Sbjct: 544  GRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLT 603

Query: 1199 FSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAE 1230
            F VKT++R++YMVAPSPEAMRIWMDVIVT A+
Sbjct: 604  FCVKTYERLFYMVAPSPEAMRIWMDVIVTAAD 635



 Score = 67.4 bits (163), Expect = 8e-11
 Identities = 95/418 (22%), Positives = 165/418 (39%), Gaps = 109/418 (26%)

Query: 577 TPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIK 636
           TPP   +  P AS+ S       +   G +   + Q+L A+  TR+ ++      +Q++K
Sbjct: 75  TPPIAMAATPPASTSSR------EGVRGAARRLQGQQLEAL--TRVALM------EQRVK 120

Query: 637 DINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHL------------------N 678
           ++  Q  E   E+++E ALL GE   E     +E+E L  L                   
Sbjct: 121 ELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQ 180

Query: 679 RKIAELEKNIVG--EKTKDA-----------------------DLLDVESKHFEDLEFQQ 713
           R++++    + G  ++ + A                       + LDV  + +EDLEFQQ
Sbjct: 181 RRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQ 240

Query: 714 LEHESRLDEEKEN---------LTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
           LE ESR +EE  +           Q+L   +A+++R  +  + +I  L++Q   + +Q  
Sbjct: 241 LERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGAL--QHRIRVLEEQLKSLGEQMA 298

Query: 765 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 824
            E     ++K   +  L +E+  L  L    + L G  G                + +EP
Sbjct: 299 AESRGLSRKKEEALQALSQERSRLLEL----NCLQGTPG---------------GDFSEP 339

Query: 825 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 884
               T L  + +   D   +  + A A  A+ P S   F        Q   GL  + +LP
Sbjct: 340 NPALTKLLFTQK--TDRQLLVLQDAVAHSAATPTSSCLFS--VHSSLQGSIGLQRTGSLP 395

Query: 885 RKK--------TTSSISPHFSSATMGRSITP----KAHLPL------GQSNSCGSVLP 924
           RK+        +   +S H + +    ++ P        PL      G+ NSCG++ P
Sbjct: 396 RKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHP 453


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 67.4 bits (163), Expect = 8e-11
 Identities = 139/673 (20%), Positives = 269/673 (39%), Gaps = 94/673 (13%)

Query: 458  RQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQ-KINKELEKL-QL 515
            +Q +E L +Q  E+    R              D  LS  T+V ++  ++N+  EK+ QL
Sbjct: 592  KQAQENLHDQVQEQKAHLR-----------AAQDRVLSLETSVNELNSQLNESKEKVSQL 640

Query: 516  SDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLT 575
              +     E L+S +      R D     D A   +  Q         +T+ D++ + L 
Sbjct: 641  DIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQ--NALQDKQQELNKITTQLDQVTAKLQ 698

Query: 576  RTPPPPSSTFPKASS-ESSYLSILPKTPEGISE----EQRSQELAAMEETRIVILNNLEE 630
                  S         +  YLS+  KT E   +    E  S E+ A +E     L +L++
Sbjct: 699  DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA---LQDLQQ 755

Query: 631  LKQKIKDINDQMDESFRELDMECAL-----LDGEQKSETTELMKEKEILDHLNRKIAELE 685
             +Q   D+  +  E  ++L+ME  +     LD ++KSE  E +K+K       ++I + +
Sbjct: 756  QRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD 815

Query: 686  KNIVGEKTK--DADLLDVESKHFEDLEFQQLEHESRLDE------EKENLTQQLLREVAE 737
               + ++TK    +L +       +L+  ++E E+ + E      +   ++  L    +E
Sbjct: 816  FETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE 875

Query: 738  YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSS 797
            +++     K  I  L+K    +  Q Q + ++ +KE+  L   L++EKE    L+ + +S
Sbjct: 876  FEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNS 935

Query: 798  LSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPST-QFPADADAVATEPATAVL--- 853
            +   +      NTLK+   +  E  +  GN   L  S+ Q     +A+  E   AVL   
Sbjct: 936  MQ--EQLIQAQNTLKQ---NEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKT 990

Query: 854  ------------ASQPQSKE---------HFRSLEERKKQHKEGLY--LSDTLPRKKTTS 890
                        A+Q  + E         ++   +E  KQ +   Y   S+ L  ++   
Sbjct: 991  ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLK 1050

Query: 891  SISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSE 950
            S+    S   + +         +G  N     L  + A + +DS  +        QQ+ E
Sbjct: 1051 SVEEKLS---LAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKK-------EQQLQE 1100

Query: 951  GHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISS 1010
              +   +     + +    +N         K +  +   +      E +       +   
Sbjct: 1101 RCKALQDIQKEKSLKEKELVNE--------KSKLAEIEEIKCRQEKEITKLNEELKSHKL 1152

Query: 1011 ASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRL-QEET 1069
             S   I  +++ ++LL Q   E        + + ++ K A+E+EKR ++IL+ ++ +EE 
Sbjct: 1153 ESIKEITNLKDAKQLLIQQKLE-------LQGKADSLKAAVEQEKRNQQILKDQVKKEEE 1205

Query: 1070 SQRQKLIEKEVKI 1082
              +++ IEKE K+
Sbjct: 1206 ELKKEFIEKEAKL 1218



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 144/732 (19%), Positives = 285/732 (38%), Gaps = 87/732 (11%)

Query: 413  GSVEFDEADLESLRQASGTPQPA---LRERKSSISSISGR--DDLMDYHRRQREERLREQ 467
            G V    A+L+SL Q     Q     +++ K      + +   ++ D   +  EER   +
Sbjct: 128  GLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE 187

Query: 468  EMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 527
              E+   +  E +           + L     +EDV  + KEL ++Q   +    E    
Sbjct: 188  AAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERE 247

Query: 528  SPDTRYRCHRKDSLPDADLASCGSLSQSSA-----------------SFFTPRSTRNDEL 570
            S   +  C +  S   +  A+   L    A                 S     + +N  L
Sbjct: 248  SEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTL 307

Query: 571  LSDLTRTPPPPSSTFPKASSESSYLSILPKT--PEGISEEQRSQELAAMEET--RI-VIL 625
              +L +     +    K + ES     +  T   + +  +Q    L+A E +  RI V L
Sbjct: 308  TENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL 367

Query: 626  NNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELE 685
            +   E  QK+K+   +++  ++ L  E   L  +++ +    ++ +  ++ L+ K+ E E
Sbjct: 368  SEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427

Query: 686  KNIVGEKTKDADLLDVESKHFEDLEFQQLEHE---SRLDEE-KENLT-----QQLLREVA 736
            + +     +  +   + S+   D E Q  + +   SRL+E+ KE +T     Q  L +  
Sbjct: 428  RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK 487

Query: 737  EYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK-- 794
            +  +   + ++  +A  ++A + ++Q  R+     ++  NL  +LQ+ KEN+  LEK+  
Sbjct: 488  QQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547

Query: 795  --YSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAV 852
              Y+ +  G+G     N L+E   ++ E        T L+   +  +++   A E     
Sbjct: 548  DLYAKIQAGEGETAVLNQLQEKNHTLQE------QVTQLTEKLKNQSESHKQAQENLHDQ 601

Query: 853  LASQPQSKEHFRSLEER--------------KKQHKEGLYLSDTLPRKKTTSSISPHFSS 898
            +  Q   K H R+ ++R                + KE +   D   + KT   +S    +
Sbjct: 602  VQEQ---KAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA--EA 656

Query: 899  ATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEF 958
            A   +    + HL   Q+           A   K  E  ++    +  Q++   + K E 
Sbjct: 657  AKTAQRADLQNHLDTAQN-----------ALQDKQQELNKITTQLD--QVTAKLQDKQEH 703

Query: 959  YNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSIS-ACSPDNISSASTSNIA 1017
             ++  S    Y   +   +   ++       L+ +DS+E   S   +  ++      N  
Sbjct: 704  CSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE-ADSLEVKASKEQALQDLQQQRQLNTD 762

Query: 1018 RIEEMERLLKQAHAEK-----TRL-LESREREMEAKKRALEEEKRRREILEKRLQEETSQ 1071
                   L KQ   EK     TRL L+ +   +E+ K+ L +++  ++IL++   E  SQ
Sbjct: 763  LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDF-ETLSQ 821

Query: 1072 RQKLIEKEVKIR 1083
              K+  +E+  R
Sbjct: 822  ETKIQHEELNNR 833



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 78/395 (19%), Positives = 162/395 (41%), Gaps = 52/395 (13%)

Query: 420  ADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLET 479
            A    L+    T Q AL++++  ++ I+ + D +    + ++E   + E    E +    
Sbjct: 660  AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYK---- 715

Query: 480  ILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKD 539
                       +  LS     E+++   K+LE   L  + S  E+AL     + + +   
Sbjct: 716  -----------EKYLSLEQKTEELEGQIKKLEADSLEVKASK-EQALQDLQQQRQLNTDL 763

Query: 540  SLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILP 599
             L   +L+    + +   S     STR      DL +      S   K + +     IL 
Sbjct: 764  ELRATELSKQLEMEKEIVS-----STR-----LDLQKKSEALESIKQKLTKQEEEKQILK 813

Query: 600  KTPEGISEEQRSQ-------------ELAAMEETRIVILNNLEELKQKIKDINDQMDESF 646
            +  E +S+E + Q             EL  ++  +  ++  L  +K K+  ++D +  S 
Sbjct: 814  QDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK 873

Query: 647  RELDME-----CALLDGEQKSETTELMKEKEI-LDHLNRKIAELEKNIVGEKTKDADLLD 700
             E + E      A+LD E+  +  EL  + ++ +++  ++  EL+K++  EK     L  
Sbjct: 874  SEFEKENQKGKAAILDLEKTCK--ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQL-- 929

Query: 701  VESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIV 760
                    ++ Q ++ ++ L ++ E   QQL   + E +++   +K++I AL+ +    V
Sbjct: 930  --KLELNSMQEQLIQAQNTL-KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAV 986

Query: 761  QQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
             Q    ++   ++       L  EKE +  L+  Y
Sbjct: 987  LQKTELENKLQQQLTQAAQELAAEKEKISVLQNNY 1021


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 102/496 (20%), Positives = 201/496 (40%), Gaps = 79/496 (15%)

Query: 618  EETRIVILNNLEELKQKIKDINDQMDE---SFRELDMECALLDGEQKSETTELM------ 668
            EE   ++ N  ++++  I+D+ +Q+DE   + ++L +E    + + K    E++      
Sbjct: 935  EERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQN 994

Query: 669  ----KEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKH---FEDLEFQQLEHESRLD 721
                KEK++++    +IAE    +  E+ K  +L  + +K      DLE ++L+ E +  
Sbjct: 995  SKFIKEKKLMED---RIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLE-ERLKKEEKTR 1050

Query: 722  EEKENLTQQLLREVAEYQRNIVSRKEKISALKKQA---NHIVQQAQREQDHFVKEKNNLI 778
            +E E   ++L  E  + Q  I   + +I  LK Q       +Q A    D     KNN +
Sbjct: 1051 QELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL 1110

Query: 779  MMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFP 838
             +++  +  +  L++ + S    +      N  ++    ++E  E           T+  
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASR------NKAEKQKRDLSEELEAL--------KTELE 1156

Query: 839  ADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTT-SSISPHFS 897
               D  A +        Q +  E  ++LEE  K H+    + D   R  T    +S    
Sbjct: 1157 DTLDTTAAQQELRTKREQ-EVAELKKALEEETKNHEA--QIQDMRQRHATALEELSEQLE 1213

Query: 898  SATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN----HQQMSEGHR 953
             A   ++   K    L   N   +     L  +  +SE +R          H ++SEG R
Sbjct: 1214 QAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDR 1273

Query: 954  QKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSA-- 1011
             + E   + +   N                          D++ T +       I  A  
Sbjct: 1274 LRVELAEKASKLQN------------------------ELDNVSTLLEEAEKKGIKFAKD 1309

Query: 1012 STSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRAL----EEEKRRREILEKR--- 1064
            + S  +++++ + LL++   +K  L  SR R++E +K +L    EEE+  R+ LEK+   
Sbjct: 1310 AASLESQLQDTQELLQEETRQKLNL-SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLA 1368

Query: 1065 LQEETSQRQKLIEKEV 1080
            LQ + +  +K ++ ++
Sbjct: 1369 LQSQLADTKKKVDDDL 1384



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 140/707 (19%), Positives = 270/707 (38%), Gaps = 94/707 (13%)

Query: 394  SLLAGESDRVFATRRNFSCGSVEF--DEADLESLRQASGTPQPALRERKSSISSISGRDD 451
            S L  E D V           ++F  D A LES  Q +   Q  L+E      ++S R  
Sbjct: 1283 SKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT---QELLQEETRQKLNLSSRIR 1339

Query: 452  LMDYHRRQREERLREQEMER--LERQRLETILSLCAEYTKPDSRLSTGTTVEDVQK-INK 508
             ++  +   +E+  E+E  R  LE+Q L     L     K D  L T  ++E+ +K + K
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399

Query: 509  ELEKL-QLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 567
            + E L Q  +E+++  + L     R +    D   D D        +  AS    +  + 
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH------QRQVASNLEKKQKKF 1453

Query: 568  DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQE-LAAMEETRIVILN 626
            D+LL++        +    +A +E+       K  + +S  +  +E L A EE       
Sbjct: 1454 DQLLAEEKSISARYAEERDRAEAEAR-----EKETKALSLARALEEALEAKEEFE----R 1504

Query: 627  NLEELKQKIKDI---NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAE 683
              ++L+  ++D+    D + ++  EL+     L+ + +   T+L + ++ L         
Sbjct: 1505 QNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLR 1564

Query: 684  LEKNIVGEKT---KDADLLDVESKHFEDLEFQQL-EHESRLDEEKENLTQQLLREVAEYQ 739
            LE N+   K    +D    D +++  + L  +Q+ E E+ L++E++       R +A   
Sbjct: 1565 LEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ------RALA--- 1615

Query: 740  RNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML---QREKENLCNLEKKYS 796
               V+ K+K+    K     ++ A + +D  +K+   L   +   QRE E       +  
Sbjct: 1616 ---VASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIF 1672

Query: 797  SLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPAD--ADAVATEPA--TAV 852
            + S       +   LK     + ++ E   +S       +   D  AD +    +  +A+
Sbjct: 1673 AQS-----KESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727

Query: 853  LASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLP 912
            L  + + +     LEE  ++ +  + L +   RK T                        
Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL----------------------- 1764

Query: 913  LGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQ---QMSEGHRQKSEFYNRTASESNVY 969
              Q ++  + L    +A  K   +R+ L   N +   ++ E        +  T S     
Sbjct: 1765 --QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAK 1822

Query: 970  LNSFHYP-DHSYKDQAFDTLSLDSSDS------METSISACSPDNISSASTSNIARIEEM 1022
            +       +   K++A     +  ++       M+        D          AR++++
Sbjct: 1823 IGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQL 1882

Query: 1023 ERLLKQAHAEKTRLLESR---EREMEAKKRALEEEKRRREILEKRLQ 1066
            +R L++A  E TR   SR   +RE++    A E   R    L+ RL+
Sbjct: 1883 KRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 112/586 (19%), Positives = 229/586 (39%), Gaps = 108/586 (18%)

Query: 607  EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLD---GEQKSE 663
            EE++++ LA +   + V++++LEE  +K +    +++++ R+LD E   L     E +++
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1077

Query: 664  TTEL-----MKEKE--------------------ILDHLNRKIAELEKNIVGEK------ 692
              EL      KE+E                    ++  L  +IAEL+++   EK      
Sbjct: 1078 IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137

Query: 693  -------TKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSR 745
                   +++ + L  E +   D    Q E  ++ ++E   L + L  E   ++  I   
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197

Query: 746  KEKISALKKQANHIVQQAQREQDHFVKEKNNL----------IMMLQREKENLCNLEKK- 794
            +++ +   ++ +  ++QA+R + +  K K  L          + +LQ+ K    +  KK 
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL 1257

Query: 795  -------YSSLSGGKGFPV----NPNTLKEGYISVNEINEP--------CGNSTNLSPST 835
                   ++ +S G    V      + L+    +V+ + E           ++ +L    
Sbjct: 1258 DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL 1317

Query: 836  QFPADADAVATEPATAVLASQPQSKEHFRSLEE--------RKKQHKEGLYLSDTL--PR 885
            Q   +     T     + +   Q +E   SL+E        RK   K+ L L   L   +
Sbjct: 1318 QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTK 1377

Query: 886  KKTTSSISPHFSSATMGRSITPKAHL---PLGQSNSCGSVLPPSLAAMAKDSESRRMLRG 942
            KK    +    S     + +   A      L +       L  +   + ++ +   +   
Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLD 1437

Query: 943  YNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISA 1002
            +  Q  S   +++ +F    A E ++   S  Y +   +D+A        +++ E    A
Sbjct: 1438 HQRQVASNLEKKQKKFDQLLAEEKSI---SARYAEE--RDRA-------EAEAREKETKA 1485

Query: 1003 CSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESRE------REMEAKKRALEEEKR 1056
             S   ++ A    +   EE ER  KQ  A+   L+ S++       E+E  KRALE++  
Sbjct: 1486 LS---LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQV- 1541

Query: 1057 RREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKE 1102
              E +  +L+E   + Q   + ++++    +A      R L  R E
Sbjct: 1542 --EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDE 1585



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 73/375 (19%), Positives = 158/375 (42%), Gaps = 39/375 (10%)

Query: 438  ERKSSISSISGRDDLM--DYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS 495
            E+  +++ I  + ++M  D   R ++E    QE+E+ +R+       L  E T    +++
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK-------LDGETTDLQDQIA 1072

Query: 496  TGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 555
                  ++Q    EL KLQL+ +E   + AL   D     H+ ++L          +++ 
Sbjct: 1073 ------ELQAQIDEL-KLQLAKKEEELQGALARGDDE-TLHKNNALKVVRELQA-QIAEL 1123

Query: 556  SASFFTPRSTRN----------DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGI 605
               F + +++RN          +EL +  T       +T  +    +     + +  + +
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183

Query: 606  SEEQRSQE--LAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSE 663
             EE ++ E  +  M +     L  L E  ++ K     ++++ + L+ +    + E   E
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD----NKELACE 1239

Query: 664  TTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEE 723
               L + K   +H  +K+ + +   +  K  + D L VE          +L++ S L EE
Sbjct: 1240 VKVLQQVKAESEHKRKKL-DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEE 1298

Query: 724  KENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQR 783
             E    +  ++ A  +  +   +E +    +Q  ++  + ++ ++    EKN+L    + 
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEE----EKNSLQEQQEE 1354

Query: 784  EKENLCNLEKKYSSL 798
            E+E   NLEK+  +L
Sbjct: 1355 EEEARKNLEKQVLAL 1369



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 42/190 (22%), Positives = 91/190 (47%), Gaps = 16/190 (8%)

Query: 608  EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 667
            + + +EL  ++E +  +   LEE+++K + + ++ +    +L  E  L   E +     L
Sbjct: 855  QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF-AEAEEMRARL 913

Query: 668  MKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESK---HFEDLEFQQLEHESRLDEEK 724
              +K+ L+ +   + +LE  +  E+ ++  L + + K   H +DLE Q       LDEE 
Sbjct: 914  AAKKQELEEI---LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ-------LDEE- 962

Query: 725  ENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE 784
            E   Q+L  E    +  I   +E+I  L+ Q +  +++ +  +D  + E ++ +   + +
Sbjct: 963  EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR-IAECSSQLAEEEEK 1021

Query: 785  KENLCNLEKK 794
             +NL  +  K
Sbjct: 1022 AKNLAKIRNK 1031



 Score = 38.9 bits (89), Expect = 0.031
 Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 11/87 (12%)

Query: 1011 ASTSNIARIEEMERLL---KQAHAEKTRLLESREREMEAKKRALEEEKRRREI----LEK 1063
            A T   A  EEM   L   KQ   E    LESR  E E + + L+ EK++ +     LE+
Sbjct: 898  AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957

Query: 1064 RLQEETSQRQKL----IEKEVKIRERQ 1086
            +L EE   RQKL    +  E KI++ +
Sbjct: 958  QLDEEEGARQKLQLEKVTAEAKIKKME 984



 Score = 38.5 bits (88), Expect = 0.040
 Identities = 140/771 (18%), Positives = 302/771 (39%), Gaps = 103/771 (13%)

Query: 418  DEADLESLRQASGTP-QPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER-Q 475
            D  D  + +Q   T  +  + E K ++   +   +      RQR     E+  E+LE+ +
Sbjct: 1157 DTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216

Query: 476  RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYR 534
            R +  L    +  + D++      V+ +Q++  E E  +   +  V E  A +S   R R
Sbjct: 1217 RFKANLEKNKQGLETDNK-ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR 1275

Query: 535  CH--RKDSLPDADLASCGSLSQSS----------ASFFTPRSTRNDELLSDLTRTPPPPS 582
                 K S    +L +  +L + +          A+    +     ELL + TR     S
Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335

Query: 583  STFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETR---------IVILNNLEELKQ 633
            S   +   E + L    +  E   +    Q LA   +           +  + +LEE K+
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395

Query: 634  K-IKD---INDQMDE---SFRELDMECALLDGEQKSETTELMKEKEILDHLNRK------ 680
            K +KD   ++ +++E   ++ +L+     L  E    T +L  ++++  +L +K      
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455

Query: 681  -IAELEKNIVGEKTKDADLLDVESKHFEDL----------------EFQQLEHESRLD-- 721
             +AE EK+I     ++ D  + E++  E                  EF++   + R D  
Sbjct: 1456 LLAE-EKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514

Query: 722  -------------EEKENLTQQLLREVAEYQRNIVSRKEKISA-----LKKQANHIVQQA 763
                          E E   + L ++V E +  +   ++++ A     L+ + N    +A
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574

Query: 764  QREQDHFVK-----EKNNLIMMLQREKENLCNLEKKYSSL--SGGKGFPVNPNTLKEGYI 816
            Q E+D   +     EK  L++   RE E     E+K  +L  +  K   ++   L+    
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIE 1634

Query: 817  SVNEI-NEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKE 875
            + N+  +E       L    +        A      + A   +S++  +SLE    Q +E
Sbjct: 1635 AANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE 1694

Query: 876  GLYLSDTLPR--KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKD 933
             L  S+   R  ++    ++   +++  G+S        L +       L   +A + ++
Sbjct: 1695 ELASSERARRHAEQERDELADEITNSASGKSAL------LDEKRR----LEARIAQLEEE 1744

Query: 934  SESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSS 993
             E  +     N + +++  R+ +   +   +E     ++    D++ +        L + 
Sbjct: 1745 LEEEQS----NMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAK 1800

Query: 994  -DSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALE 1052
               +E ++ +     I SA  + I ++EE      +  A   +L+   E++++     +E
Sbjct: 1801 LQELEGAVKSKFKATI-SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVE 1859

Query: 1053 EEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKED 1103
            +E+R  +  ++++ E+ + R K ++++++  E +  +A    R L    +D
Sbjct: 1860 DERRHADQYKEQM-EKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909



 Score = 30.8 bits (68), Expect = 8.4
 Identities = 22/83 (26%), Positives = 43/83 (51%), Gaps = 11/83 (13%)

Query: 1040 REREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQR------AQARPL 1093
            +E E++AK   L + K ++  +E  L+E   + Q+L+E++  + E+ +      A+A  +
Sbjct: 850  QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909

Query: 1094 TRYLPVRKEDF-----DLRSHVE 1111
               L  +K++      DL S VE
Sbjct: 910  RARLAAKKQELEEILHDLESRVE 932


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 150/717 (20%), Positives = 285/717 (39%), Gaps = 89/717 (12%)

Query: 422  LESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETIL 481
            LE+L+Q     +  L+  K +I S   +  L+       +E L+EQ  ERL  Q LE I 
Sbjct: 281  LETLQQRVKRQENLLKRCKETIQSHKEQCTLLT----SEKEALQEQLDERL--QELEKIK 334

Query: 482  SL-CAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDS 540
             L  AE TK  ++L       D + + ++LE+          ++ ++  +T+ + H    
Sbjct: 335  DLHMAEKTKLITQL------RDAKNLIEQLEQ----------DKGMVIAETKRQMHETLE 378

Query: 541  LPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPK 600
            + + ++A   S  +         +T+ +EL     ++         KA S +       +
Sbjct: 379  MKEEEIAQLRSRIKQM-------TTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431

Query: 601  TPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ 660
              +   +EQ        EE RI +   L  +KQ++ D+  +  E       + A L   Q
Sbjct: 432  KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEE------QIAKL---Q 482

Query: 661  KSETTEL-MKEKEILDHLNRKIAELEK--NIVGEKTKDADL-LDVESKHFEDLEFQQLEH 716
            K    EL  KE+E+   L  +  E ++   +  EK++   L +  E +  E L  ++LE 
Sbjct: 483  KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELEL 542

Query: 717  ESR-LDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKN 775
            + + +  E EN  + L +E   Y+  I+   E  S+L+K       Q++    H   EKN
Sbjct: 543  QKKAILTESENKLRDLQQEAETYRTRIL---ELESSLEKSLQENKNQSKDLAVHLEAEKN 599

Query: 776  ----NLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGY-ISVNEINEPCGNSTN 830
                 + +M+++ K  L +L+ +  +L     +      LK+ Y   + ++ E C     
Sbjct: 600  KHNKEITVMVEKHKTELESLKHQQDAL-----WTEKLQVLKQQYQTEMEKLREKCEQEKE 654

Query: 831  L---SPSTQFPADADAVATEPATAVLASQPQ----SKEHFRSLEERKKQHKEGLYLSDTL 883
                     F A  + +  +    +   Q +    S E    L+ R K  +E   L D  
Sbjct: 655  TLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQT 714

Query: 884  PRKKTTSSISPHFSS---ATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRML 940
             + K                   SI  +  + + ++          L  + K+ + + + 
Sbjct: 715  DKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERD-KHLK 773

Query: 941  RGYNHQQMSEGHRQKSEFYNRTASES----NVYLNSFHYPDHSYKDQAFD----TLSLDS 992
                H +  E   ++SE   + AS        Y ++ H    +Y++Q        L L++
Sbjct: 774  EHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLET 833

Query: 993  SDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALE 1052
               + T   A          T   A   +++ L++Q        LE +  EME K ++L 
Sbjct: 834  ERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ--------LEKQNSEMEQKVKSLT 885

Query: 1053 EEKRRREILEKRLQEETSQRQKLIEKE---VKIRERQRAQARPLTRYLPVRKEDFDL 1106
            +    +  LE   +E+   +Q L+EKE   +++RE Q+ +   LT+ L  +++   +
Sbjct: 886  QVYESK--LEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHI 940



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 73/372 (19%), Positives = 161/372 (43%), Gaps = 37/372 (9%)

Query: 436  LRERKSSISSISGRDDLMDYHRRQREERLREQE--MERLERQRLETI--LSLCAEYTKPD 491
            ++  K+ I S+    + +      +++   E+E  + +L+++  E I  ++L  E  K +
Sbjct: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELK-E 1364

Query: 492  SRLSTGTTVEDVQKINKELEK-LQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCG 550
             ++   +  + +  +N +L+  + LS++E+         D   +C   D + D       
Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEE-KCELLDQVQDLSF-KVD 1422

Query: 551  SLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQR 610
            +LS+   S       + D+  +  +       S F +  +    L I          E +
Sbjct: 1423 TLSKEKISALE----QVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI--------QLELK 1470

Query: 611  SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKE 670
            S+E    +E   ++   L++  ++   +  +M++   +++ + + L+ E KS+T  +M  
Sbjct: 1471 SKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM-- 1528

Query: 671  KEILDHLNRKIAELEKNIVGEKTKDADLL-DVESKHFEDLEFQQLEHESRLDEEKENLTQ 729
             E+ DH+ +K  E+E   + E  K+ +   D+E K       Q+L+H   L EEK+N  +
Sbjct: 1529 -ELEDHITQKTIEIES--LNEVLKNYNQQKDIEHKEL----VQKLQHFQELGEEKDNRVK 1581

Query: 730  QLLREVAEYQRNIVSRKEKISALKKQANHI---VQQAQRE----QDHFVKEKNNLIMMLQ 782
            +   ++   +  + S K ++   KK+  H+   V+  + E    +D    E    +  L+
Sbjct: 1582 EAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELK 1641

Query: 783  REKENLCNLEKK 794
            R+ E      KK
Sbjct: 1642 RKAEQKIAAIKK 1653



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 107/561 (19%), Positives = 218/561 (38%), Gaps = 76/561 (13%)

Query: 600  KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
            KT E +  +Q   EL ++      +L    +L++++  + DQ D+  +EL+ +       
Sbjct: 674  KTLEKLDVKQT--ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNH 731

Query: 660  QKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL-LDVESKHFEDLEFQQLEHES 718
             + +   ++KE E+      K  + + N +    K+ D  L     H E+LE      E 
Sbjct: 732  HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEG 791

Query: 719  RLDEEKENL-------------TQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQR 765
             L +    L             T+    ++A+ Q+ ++  + +   L KQ   +  Q + 
Sbjct: 792  ELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKD 851

Query: 766  EQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS---------GGKGFPVNPNTLKEGYI 816
                    K  +  ++Q+ ++    +E+K  SL+         G K        L E   
Sbjct: 852  VCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKEN 911

Query: 817  SVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQS--KEHFRSLEERKKQHK 874
             + ++ E  G    +   TQ        A E +  +L  + ++  K   + +E+ K++ K
Sbjct: 912  MILQMRE--GQKKEIEILTQ-----KLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 964

Query: 875  EGLYLSDTLPRK--KTTSSISPHFSSATMGRSITPKAH----LPLGQSNSCGSVLPPSLA 928
            E   + +TL +K     + +     +  +  S   K      L + Q+NS G     S A
Sbjct: 965  E---MQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGI----SDA 1017

Query: 929  AMAKDSESRRMLRGYNHQQMSEGHRQK----SEFYNRTASESNVYLNSFHYPDHSYKDQA 984
                ++  +  +     + ++E HR++       + +  ++    L   H      K+Q 
Sbjct: 1018 VSRLETNQKEQI-----ESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQE 1072

Query: 985  FDTLSLD------SSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLE 1038
               L           + M   I+    + +   +T N     E++  LKQ  A    L +
Sbjct: 1073 VAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLN-----ELQEQLKQKSAHVNSLAQ 1127

Query: 1039 SREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLP 1098
              E +++A    LE +      L K L+E T  +++L+E ++ + E  + +   LT  L 
Sbjct: 1128 D-ETKLKAHLEKLEVD------LNKSLKENTFLQEQLVELKM-LAEEDKRKVSELTSKLK 1179

Query: 1099 VRKEDF-DLRSHVETAGHNID 1118
               E+F  L+S  E +  +++
Sbjct: 1180 TTDEEFQSLKSSHEKSNKSLE 1200



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 142/670 (21%), Positives = 257/670 (38%), Gaps = 100/670 (14%)

Query: 459  QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDE 518
            ++EE  +E    + E  + +T L+   E  K  S     +  +D  K+   LEKL++   
Sbjct: 1086 EKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSA-HVNSLAQDETKLKAHLEKLEVDLN 1144

Query: 519  ESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDL---- 574
            +S+ E   +                 +L       +   S  T +    DE    L    
Sbjct: 1145 KSLKENTFLQEQL------------VELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSH 1192

Query: 575  ---TRTPPPPSSTFPKASSESSY-LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEE 630
                ++    S  F K S E +  L I  K  E + E + ++ +         IL+ +  
Sbjct: 1193 EKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISH 1252

Query: 631  LKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILD----HLNRKIAELEK 686
             + +   + + +      L   C +   E +++  +L +E+  L+        ++ E E 
Sbjct: 1253 CQHRTTKVKEAL------LIKTCTV--SELEAQLRQLTEEQNTLNISFQQATHQLEEKEN 1304

Query: 687  NIVGEKTKDADLLDVESKHFEDLEFQQLE-HESRLDEEKENLTQQLLREVAE-------Y 738
             I   K       D+ES   E    Q+   ++ +   EKE+   QL +E++E        
Sbjct: 1305 QIKSMKA------DIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLM 1358

Query: 739  QRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE-KENLCNLEKKYSS 797
            +  +  +K +IS+L KQ   +  Q Q      + EK   I  L+++  E  C L  +   
Sbjct: 1359 KEELKEKKVEISSLSKQLTDLNVQLQNSIS--LSEKEAAISSLRKQYDEEKCELLDQVQD 1416

Query: 798  LSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQP 857
            LS    F V+  TL +  IS  E  +   N  +     ++   A +  T+    V   Q 
Sbjct: 1417 LS----FKVD--TLSKEKISALEQVDDWSNKFS-----EWKKKAQSRFTQHQNTVKELQI 1465

Query: 858  Q----SKEHFRS-------LEERKKQHK-----EGLYLSDTLPRKKTTSSISPHFSSATM 901
            Q    SKE +          EE  +Q+K     +G    D    +K  S++     S T 
Sbjct: 1466 QLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQT- 1524

Query: 902  GRSITPKAHLPLG--QSNSCGSVLPPSLAAMAKDSESRRMLRGYNH-QQMSE--GHRQKS 956
             R +  + H+     +  S   VL        KD E + +++   H Q++ E   +R K 
Sbjct: 1525 ARIMELEDHITQKTIEIESLNEVLKNY--NQQKDIEHKELVQKLQHFQELGEEKDNRVKE 1582

Query: 957  EFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNI 1016
                    E+ VY       +   K +  + ++L S  S E  + A   D + S S + +
Sbjct: 1583 AEEKILTLENQVYSMK---AELETKKKELEHVNL-SVKSKEEELKALE-DRLESESAAKL 1637

Query: 1017 ARIEEM---------ERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQE 1067
            A ++           ++LL Q   ++ +  +  E  +      L+E +R   ILE++L+ 
Sbjct: 1638 AELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKS 1697

Query: 1068 -ETSQRQKLI 1076
             E+SQ + LI
Sbjct: 1698 VESSQSETLI 1707



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 111/550 (20%), Positives = 209/550 (38%), Gaps = 61/550 (11%)

Query: 605  ISEEQRSQELAAME-----ETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
            +S + + +EL A+E     E+   +     + +QKI  I  Q+     E + +       
Sbjct: 1613 LSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTES 1672

Query: 660  QKSETTELMKEKEILDH-LNRKIAELEKN-----IVGEKTKDADLLDVESKHFEDLEFQQ 713
              SE    ++E+E   H L  K+  +E +     IV    K+      E +  +     Q
Sbjct: 1673 HLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAY-TEQEEADSQGCVQ 1731

Query: 714  LEHESRLDEEKENLTQQ--LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFV 771
              +E ++   + NLT++  LL+ V + +   VS   ++    ++    ++ A+ +Q    
Sbjct: 1732 KTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQH--- 1788

Query: 772  KEKNNLIMMLQREKENLCNLEKKYSSL-------SGGKGFPVNPNTLKEGYISVNEINEP 824
             E  ++I  LQ E E      KKYS +        GGK        L+  +  V +  + 
Sbjct: 1789 -EDQSMIGHLQEELEEK---NKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQE 1844

Query: 825  CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSK-EHFRSLEERKKQHKEGLYLSDTL 883
               +  +        D+  V  +    V   +  SK E  ++L++   ++K    L +  
Sbjct: 1845 KELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENT 1904

Query: 884  PRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGY 943
              K  +  + P   S    +    +  L   +       L   +  + KD    RMLR  
Sbjct: 1905 EEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREK--QKLGKEIVRLQKDL---RMLRKE 1959

Query: 944  NHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISAC 1003
            + Q++    ++  +       +    L   H        + F+T        +E +I   
Sbjct: 1960 HQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIK-- 2017

Query: 1004 SPDNISSASTSNIARIE----EMERLLKQAHAEK-----------TRLLESREREMEAKK 1048
              + I+ A       +E    E  +LLK+  AEK             +L++RE EM AK 
Sbjct: 2018 --ETINKAQEVEAELLESHQEETNQLLKKI-AEKDDDLKRTAKRYEEILDAREEEMTAKV 2074

Query: 1049 RALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRS 1108
            R L+ +    E L+K+ Q++  Q +      V I E Q   A+  T     + ++ + R 
Sbjct: 2075 RDLQTQ---LEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFRE 2131

Query: 1109 HVETAGHNID 1118
             +    HN++
Sbjct: 2132 QI----HNLE 2137



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 44/193 (22%), Positives = 87/193 (45%), Gaps = 19/193 (9%)

Query: 595  LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMEC- 653
            L IL K  +   EE+  QE   +E      L +   LKQ +++ N Q+ +  +EL+M   
Sbjct: 1964 LEILKKEYDQEREEKIKQEQEDLE------LKHNSTLKQLMREFNTQLAQKEQELEMTIK 2017

Query: 654  ALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQ 713
              ++  Q+ E   L   +E  + L +KIAE + ++     +  ++LD      E++  + 
Sbjct: 2018 ETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDARE---EEMTAKV 2074

Query: 714  LEHESRLDEEKENLTQQLLRE---------VAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
             + +++L+E ++   Q+L +E         + E Q  +  +   IS  K +     +Q  
Sbjct: 2075 RDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIH 2134

Query: 765  REQDHFVKEKNNL 777
              +D   K + N+
Sbjct: 2135 NLEDRLKKYEKNV 2147


>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
          Length = 1235

 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 78/399 (19%), Positives = 179/399 (44%), Gaps = 57/399 (14%)

Query: 436 LRERKSSISSISGRDDLMDYHRR----QREERLREQEMERLERQRLETILSLCAEYTKPD 491
           + E K+   +I+  +++MD +      + EE       E +E      + S+ A+     
Sbjct: 611 IEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEME------VRSVVAD----T 660

Query: 492 SRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS--- 548
            + + G+ V+D  K+  +++K +     S+ +E  ++  ++    +   +P  ++ S   
Sbjct: 661 DQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG 720

Query: 549 -----CGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPE 603
                 GSLS++  +   P S    E  +D        +S+     S SS+LS   K   
Sbjct: 721 ENKEEIGSLSKTE-TILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLS-KTKDSG 778

Query: 604 GISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSE 663
            IS ++  ++   +++TR  I++ +E      K + D  D    EL      L  ++  E
Sbjct: 779 SISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDS-DSKTEEL----RFLRRQELRE 833

Query: 664 TTELMKEKE-ILDHLNRKIAE--------LEKNIVGEKTK-DADLLDVESKHFEDLEFQQ 713
              L KE++     LN K+ +         E+ ++ +K + D ++ ++E +  + +E  +
Sbjct: 834 LRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLE 893

Query: 714 LEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI-------------SALKKQANHIV 760
            EH +RL +E + +  +  +E++++Q  + +RK+++               +K++   + 
Sbjct: 894 QEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELA 953

Query: 761 QQAQREQDHFVKEK-----NNLIMMLQREKENLCNLEKK 794
           Q    ++  FV+++      +L  ++Q++K  L N+E++
Sbjct: 954 QSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERE 992



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 125/620 (20%), Positives = 247/620 (39%), Gaps = 77/620 (12%)

Query: 505  KINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASC--GSLSQS-----SA 557
            ++ +E+E  +  DEE   E +L  P +      K +  D  +AS     LSQ+     S 
Sbjct: 310  EVTEEVEDGKEEDEEEETENSLPIPAS------KRASSDLSIASSEEDKLSQNACILESV 363

Query: 558  SFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAM 617
            S  T RS   D+L S +    P                    K  E I+E     +L AM
Sbjct: 364  SEKTERSNSEDKLNSKILNEKPTTDEP--------------EKAVEDINEHITDAQLEAM 409

Query: 618  EETR---IVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL------- 667
             E      VI  N  E + K++++ D  D+   +++   ++ +G++ +    L       
Sbjct: 410  TELHDRTAVIKENEREKRPKLENLPDTEDQETVDIN---SVSEGKENNIMITLETNIEHN 466

Query: 668  MKEKEILDHLNRKIAELEKNIVGEKTKDADL--LDVESKHFEDLEFQQLEHESRLDEEKE 725
            +K +E  D   +++ E  K I  E+ KD  L  +D+ S+   + E      +S +   KE
Sbjct: 467  LKSEEEKDQEKQQMFE-NKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKE 525

Query: 726  NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREK 785
            + TQ+ L E  + Q++++S    +    + A+ + Q+   ++D     ++N    +    
Sbjct: 526  D-TQEKLGEDDKTQKDVISNTSDVIGTCEAAD-VAQKV--DEDSAEDTQSNDGKEVVEVG 581

Query: 786  ENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVA 845
            + L N         G K  P+         + +NEI E       ++ S       +   
Sbjct: 582  QKLINKPMVGPEAGGTKEVPIKE------IVEMNEIEEGKNKEQAINSSENIMDINEEPG 635

Query: 846  TEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSI 905
            T     +  S    +   RS+     Q   G  + D     K T+ I        +    
Sbjct: 636  TTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDA---SKVTTQIDKEKKEIPVSIKK 692

Query: 906  TPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQM-----SEGHRQKSEFYN 960
             P+  + + Q      VL PS+   +   E++  +   +  +      SE  ++      
Sbjct: 693  EPEVTV-VSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSG 751

Query: 961  R--TASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP---DNIS-SASTS 1014
               TA  S++ LN         K +   ++SL  +   + ++        D +  S +TS
Sbjct: 752  TGSTADTSSIDLN-LSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTS 810

Query: 1015 NI-----ARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEET 1069
             I     ++ EE+ R L++    + R L+  E+   A+++   + +++RE + +R ++E 
Sbjct: 811  KIVTDSDSKTEEL-RFLRRQELRELRFLQKEEQR--AQQQLNSKLQQQREQIFRRFEQEM 867

Query: 1070 SQRQKLIEKEVKIRERQRAQ 1089
              +++  ++E++  E+Q+ Q
Sbjct: 868  MSKKRQYDQEIENLEKQQKQ 887


>gi|29788755 SET binding factor 2 [Homo sapiens]
          Length = 1849

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 56/228 (24%), Positives = 89/228 (39%), Gaps = 18/228 (7%)

Query: 1000 ISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRRE 1059
            +S   PD    A TS  + IE++E  L QA  +  +L E    +++ + R          
Sbjct: 1631 VSCTQPD----ALTSLFSEIEKLEHKLNQAPEKWQQLWERVTVDLKEEPRT--------- 1677

Query: 1060 ILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDT 1119
                R Q   S+   ++   +   +++     P +     +       + VE     + +
Sbjct: 1678 ---DRSQRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEEQNSSISPSNGVERRAATLYS 1734

Query: 1120 CYHVSITE-KTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAI 1178
             Y     E ++  G L K G  +K WK RWFV D  K    YY    +T  KG I    +
Sbjct: 1735 QYTSKNDENRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEV 1794

Query: 1179 EEVY-YDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1225
            E V        A K  +    F +KT  R+Y   A   ++ + WMD I
Sbjct: 1795 EMVIPAGPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDKI 1842


>gi|239735519 SET binding factor 1 [Homo sapiens]
          Length = 1893

 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 34/99 (34%), Positives = 48/99 (48%), Gaps = 1/99 (1%)

Query: 1128 KTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVY-YDHL 1186
            ++  G L K G  +K WK RWFV D+ K    YY  + +T+ KGVI    +E V      
Sbjct: 1788 RSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPT 1847

Query: 1187 KNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1225
              A K+ +    F VKT  R+Y   A    + + W+D I
Sbjct: 1848 MGAPKTVDEKAFFDVKTTRRVYNFCAQDVPSAQQWVDRI 1886


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 134/685 (19%), Positives = 267/685 (38%), Gaps = 99/685 (14%)

Query: 449  RDDLMDYHRRQREERLREQEMER-------LERQRLETILSLCAEYTKPDSRLSTGTTVE 501
            RDDL      Q++ +  E ++E        LE+++   ++ L  +    + +L       
Sbjct: 2016 RDDL------QKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069

Query: 502  DVQKINKELEKLQLSDEESVFEEAL-----MSPDTRYRCHRKDSLPD---ADLASCGSLS 553
            D Q I++E E+     E    E+ L       P + ++    + L +        C  L 
Sbjct: 2070 DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129

Query: 554  QSSASFFTPRSTRNDEL------LSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISE 607
             S          RN+E+      + +L +     + TF K      + ++  K PE   E
Sbjct: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK-PELSLE 2188

Query: 608  EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 667
             Q   E  A++     I  NLEE  ++ ++  +  +E  ++L M+  +    QK E+T  
Sbjct: 2189 VQLQAERDAIDRKEKEI-TNLEEQLEQFREELENKNEEVQQLHMQLEI----QKKESTTR 2243

Query: 668  MKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHES-----RLDE 722
            ++E E  + L +   ++EK  +G   K++D +  + +H    +F Q+  E      +L+E
Sbjct: 2244 LQELEQENKLFKD--DMEK--LGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNE 2299

Query: 723  EKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ---REQDHFVKEKNNLIM 779
            +   L QQL  ++    + I  + E I  L+ Q   ++   +   R ++  +++ N +I 
Sbjct: 2300 QVTKLQQQL--KITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357

Query: 780  MLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISV-NEINEPCGNSTNLSPSTQFP 838
             LQ+E  N+            G+   +N ++L E   S+ ++++        L    +  
Sbjct: 2358 KLQQELANI------------GQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETA 2405

Query: 839  ADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFS- 897
             +                 Q  +   SL    K+ +E +    ++P      +I  H S 
Sbjct: 2406 NEEMTFMKNVLKETNFKMNQLTQELFSL----KRERESVEKIQSIPENSVNVAID-HLSK 2460

Query: 898  ---------SATMGRSITPKAHLPLGQSNSCGSV-------LPPSLAAMAKDSESR---R 938
                     +    +S+  + +    + N  GS+       L       AKD E     +
Sbjct: 2461 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2520

Query: 939  MLRGYNHQQMSEGHRQKSEFYN---------RTASESNVYLNSFHYPDHSYKDQAFDTLS 989
             ++    Q   E    + +  N           A  S + L +    +++   Q   T+S
Sbjct: 2521 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQ--EYAKFCQDNQTIS 2578

Query: 990  LDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKR 1049
             +   +   +++    D + S  ++   RI E+E  + + H   T L+  +E+   A+K 
Sbjct: 2579 SEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMH---TSLILEKEQVEIAEKN 2635

Query: 1050 ALEEEKRRREILEKRLQEETSQRQK 1074
             LE+EK+  E+ +     E  QR+K
Sbjct: 2636 VLEKEKKLLELQKLLEGNEKKQREK 2660



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 40/200 (20%), Positives = 97/200 (48%), Gaps = 24/200 (12%)

Query: 607 EEQRSQELAAMEETRIVILNNLEEL--------------KQKIKDINDQMDESFREL--- 649
           +E+  +EL  + E +  +   LE+L              +Q I +   +++E+ + L   
Sbjct: 509 KEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTV 568

Query: 650 -DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFE 707
            D++  ++   +  +  EL  E E+ ++ +  ++ E EKN V ++  ++   ++E    +
Sbjct: 569 EDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQ 628

Query: 708 DLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI-VSRKEKISALKKQANHIVQQAQRE 766
            L      HE  L + KE+L  +    + + + N+ +  K++I  L+ + +  ++  Q E
Sbjct: 629 LL----FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFE 684

Query: 767 QDHFVKEKNNLIMMLQREKE 786
           +D+ + ++N LI+ + + K+
Sbjct: 685 KDNLITKQNQLILEISKLKD 704



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 124/684 (18%), Positives = 270/684 (39%), Gaps = 134/684 (19%)

Query: 502  DVQKINKELEKLQLS------DEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 555
            +++++N+ELE+++++       +   FE A+   D                   G ++Q 
Sbjct: 170  EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRD-------------------GIITQL 210

Query: 556  SASFFTPRSTRNDELLSDLTRTPPPP-----------SSTFPKASSESSYLSILPKTPEG 604
            +A+    R  +++ +   L  T               S T   ++  S+   +L    + 
Sbjct: 211  TANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQI 270

Query: 605  ISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSET 664
            ++ +Q+ +E   +          LE+ ++K +D   Q+  SF +  ++   ++ ++K E 
Sbjct: 271  LTHQQQLEEQDHL----------LEDYQKKKEDFTMQI--SFLQEKIKVYEMEQDKKVEN 318

Query: 665  T---ELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLD 721
            +   E+ +++ I++ LN KI E EK  +  K K    L    K   +L+ Q ++    + 
Sbjct: 319  SNKEEIQEKETIIEELNTKIIEEEKKTLELKDK----LTTADKLLGELQEQIVQKNQEIK 374

Query: 722  EEKENLT-------------QQLLREVAEYQR----------NIVSRKE-----KISALK 753
              K  LT             +QL+  V E Q+          +IV R E     K+  L+
Sbjct: 375  NMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLR 434

Query: 754  KQANHIVQQ--AQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTL 811
             + + +  Q   Q +Q+   +    +  M  R K  + N  + YS+++      VN + +
Sbjct: 435  AELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT------VNEDQI 488

Query: 812  KEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEE--- 868
            K   +++NE+N    ++   S   +   +   +  E        +   +E   S E+   
Sbjct: 489  KLMNVAINELNIKLQDTN--SQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQR 546

Query: 869  -RKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAH----------LPLGQSN 917
             R+   ++   L++      T   +     SA+  R      H          L + +  
Sbjct: 547  ARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKE 606

Query: 918  SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPD 977
               +VL     +   + E  R    ++H++     ++  E  +R   E        HY  
Sbjct: 607  K-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYK- 664

Query: 978  HSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTS---NIARIEEMERLLKQAHAEKT 1034
                 Q  D L  + S  +ET       DN+ +        I++++++++ L  + +E+ 
Sbjct: 665  -----QQIDGLQNEMSQKIETM--QFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEM 717

Query: 1035 RL-----------LESREREMEAKKRALEEEKRRREILEKRLQE-ETSQRQKLIEKEVK- 1081
             L           L   E+E    ++ ++E + + E+LEK+++E E   ++K  + E + 
Sbjct: 718  TLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAEN 777

Query: 1082 --IRERQRAQARPLTRYLPVRKED 1103
              +++ ++     L  + PV +E+
Sbjct: 778  SILKDEKKTLEDMLKIHTPVSQEE 801



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 98/456 (21%), Positives = 184/456 (40%), Gaps = 86/456 (18%)

Query: 417  FDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLER 474
            + + +  S++Q S   +P L ERK+ I++IS   DL+   + QRE  + +  Q  E    
Sbjct: 2965 YSDGEDHSIQQVS---EPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSD 3021

Query: 475  QRLETILSLCAEYTKPDSRL---------STGTT-------------VEDVQKINKELEK 512
             R E +L+L   + +  S L         + GTT              E   +    +E 
Sbjct: 3022 WRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMEC 3081

Query: 513  LQLSDEESVFEE------ALMSPDTRYRCHRKDSLPDADLASCGSLSQSS--------AS 558
            LQ +D  S+  E       +       +  ++   P  +L       + S         S
Sbjct: 3082 LQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3141

Query: 559  FFTPRSTRND-----------ELLSDLTRTPPPPSSTFPKASS-----ESSYLSILPKTP 602
                R+T              EL S+L +T     +T           E+  L +  KT 
Sbjct: 3142 SMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTD 3201

Query: 603  EG-------ISEEQRSQELA-AMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECA 654
            E         SE+++S+EL  A+E+ +  +  + E  K++++D+   + ES ++ +++  
Sbjct: 3202 EVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSL-ESQKQRNLQLN 3260

Query: 655  LL---------DGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL---LDVE 702
            LL         + +QK E+  ++ + ++ +   R + EL+  +  EK +  ++   LD E
Sbjct: 3261 LLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL-ELQVLLESEKVRIREMSSTLDRE 3319

Query: 703  SKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ 762
             +    L+      +SR     E+L ++L +++ E    IV    +    K + + +  +
Sbjct: 3320 RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETE--KYKLDSLQTR 3377

Query: 763  AQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 798
             Q E+D  V  K      LQ E+E     +KK   L
Sbjct: 3378 QQMEKDRQVHRKT-----LQTEQEANTEGQKKMHEL 3408



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 82/387 (21%), Positives = 165/387 (42%), Gaps = 45/387 (11%)

Query: 421  DLESLRQAS--GTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 478
            +LE+L+Q S  G  +     R SS  + +G ++  +      E+  +E+E++R       
Sbjct: 1659 ELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVE----EQTFKEKELDRKPEDVPP 1714

Query: 479  TILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRK 538
             ILS        + R +       + KI  E+ K   + EE++    L   D   +    
Sbjct: 1715 EILS--------NERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSS 1766

Query: 539  DSL-----PDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPS--STFPKASSE 591
             SL      +A + SC     +  +         DE +   + +  P +  + + K + E
Sbjct: 1767 ASLIWRSEAEASVKSCVHEEHTRVT---------DESIPSYSGSDMPRNDINMWSKVTEE 1817

Query: 592  SSYLS--ILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 649
             + LS  ++     G   +  ++EL     +R+     +E+L + I + + Q++ + +  
Sbjct: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAA--VEKLLEAISETSSQLEHA-KVT 1874

Query: 650  DMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDV---ESKHF 706
              E       QK E TE +K +E L     + +   + +  E +K   ++D    E   F
Sbjct: 1875 QTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLF 1934

Query: 707  EDLEFQQLEHESRLDEE---KENLTQQLLREVAEYQ--RNIVSRKEKISALKKQANHIVQ 761
            E    ++ +   RL++E     N  Q+L  E  + Q  R ++SR+++  A+K +A  + Q
Sbjct: 1935 ERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKE--AMKAEAGPVEQ 1992

Query: 762  QAQREQDHFVKEKNNLIMMLQREKENL 788
            Q  +E +  +KEK  +    ++ +++L
Sbjct: 1993 QLLQETEKLMKEKLEVQCQAEKVRDDL 2019



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 83/414 (20%), Positives = 176/414 (42%), Gaps = 55/414 (13%)

Query: 415 VEFDEADLESLRQASGTPQPALRERKSSISSISG-RDDLMDYHRRQREERLREQ------ 467
           + F    ++  RQ     +  L E   S+S++   + +++     ++E  L+ +      
Sbjct: 537 LSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNY 596

Query: 468 --EMERLERQRLETILSLCAEYTKPD-SRLSTGTTVEDVQKINKELEKLQLSDEESVFEE 524
             ++E LE+++   +L   AE  + +  RL T       ++++K  E L++    ++ E+
Sbjct: 597 KIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINI-EK 654

Query: 525 ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSST 584
              +    Y+  + D L +       ++     +  T    + ++L+ ++++      S 
Sbjct: 655 LKDNLGIHYK-QQIDGLQNEMSQKIETMQFEKDNLIT----KQNQLILEISKLKDLQQSL 709

Query: 585 FPKASSESSY-LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMD 643
               S E +  ++ L K  E + +E++ +     E   + +   L  L++++K+  + + 
Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL--LEKQMKEKENDLQ 767

Query: 644 ESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVES 703
           E F +L+ E ++L  E+K+   +++K       ++  +++ E+ I  +  K      V  
Sbjct: 768 EKFAQLEAENSILKDEKKT-LEDMLK-------IHTPVSQEERLIFLDSIKSKSKDSVWE 819

Query: 704 KHFEDLEFQQLEHESRLDEEKENLTQQL--LREVAEYQRNIVSRKEKISALKKQANHIVQ 761
           K  E            L EE E+L QQ   L E  E QRN  S  EK      + N+  Q
Sbjct: 820 KEIE-----------ILIEENEDLKQQCIQLNEEIEKQRNTFSFAEK----NFEVNY--Q 862

Query: 762 QAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGF---PVNPNTLK 812
           + Q E    +K K++L      + +N   LE K    +  +      +NP T+K
Sbjct: 863 ELQEEYACLLKVKDDL-----EDSKNKQELEYKSKLKALNEELHLQRINPTTVK 911



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 59/241 (24%), Positives = 106/241 (43%), Gaps = 46/241 (19%)

Query: 597  ILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALL 656
            +L +  E +  E    E   ++ET  ++   LE   Q  K + D + +  + L+++    
Sbjct: 1975 LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK-VRDDLQKQVKALEIDVE-- 2031

Query: 657  DGEQKSETTELMKEK--EILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDL---EF 711
              EQ S   EL +EK  E++D L ++   LEK +  +  K  D   ++ +H  D+   E 
Sbjct: 2032 --EQVSRFIELEQEKNTELMD-LRQQNQALEKQLE-KMRKFLDEQAIDREHERDVFQQEI 2087

Query: 712  QQLE--------------HESRLDE-------EKENLTQQLLREVAEYQRNIVSRKEKIS 750
            Q+LE              H++R  E       EK +   +LL    + QR+I  R E+I 
Sbjct: 2088 QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIE 2147

Query: 751  ALKKQANHIVQ---------QAQREQDHF----VKEKNNLIMMLQREKENLCNLEKKYSS 797
             L+ +   + Q         Q   ++ HF     K + +L + LQ E++ +   EK+ ++
Sbjct: 2148 KLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITN 2207

Query: 798  L 798
            L
Sbjct: 2208 L 2208



 Score = 34.7 bits (78), Expect = 0.58
 Identities = 71/346 (20%), Positives = 128/346 (36%), Gaps = 77/346 (22%)

Query: 458  RQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKL--QL 515
            +Q  E LR+  M ++ERQR                        ED +++ +E+++L  QL
Sbjct: 1602 QQATELLRQAHMRQMERQR------------------------EDQEQLQEEIKRLNRQL 1637

Query: 516  SDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASFFTPRSTRNDELL 571
            +   S+  E L+S   R      ++L    LA     C  L  SS    T     N   +
Sbjct: 1638 AQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ--TQNGNENQGEV 1695

Query: 572  SDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEEL 631
             +          TF +          L + PE +  E  S E  A+++    +L  L E+
Sbjct: 1696 EE---------QTFKEKE--------LDRKPEDVPPEILSNERYALQKANNRLLKILLEV 1738

Query: 632  KQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELE-KNIVG 690
             +    + + +            +LD   KS+++  +        + R  AE   K+ V 
Sbjct: 1739 VKTTAAVEETIGRHV------LGILDRSSKSQSSASL--------IWRSEAEASVKSCVH 1784

Query: 691  EKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLR----------EVAEYQR 740
            E+        + S    D+    +   S++ EE   L+Q+L+R          E  E   
Sbjct: 1785 EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELML 1844

Query: 741  NIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKE 786
            NI SR   + A  ++    + +   + +H    +  L+    R+K+
Sbjct: 1845 NISSR---LQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ 1887



 Score = 34.7 bits (78), Expect = 0.58
 Identities = 44/193 (22%), Positives = 73/193 (37%), Gaps = 27/193 (13%)

Query: 618  EETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHL 677
            E T I  LN L E         D++      L +  + L+ +     T L+ EKE ++  
Sbjct: 2582 ERTNIQNLNQLRE---------DELGSDISALTLRISELESQVVEMHTSLILEKEQVEIA 2632

Query: 678  NRKIAELEKNIVG-------------EKTKDADLLDVESKHFEDLEFQQLEHESRLDEEK 724
             + + E EK ++              EK K     DVE        F   E ES    E 
Sbjct: 2633 EKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNE-ESGFFNEL 2691

Query: 725  ENLTQQLLR---EVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML 781
            E L  + +    E+A Y+      +E++   +     + +   + +DH  + K  L  +L
Sbjct: 2692 EALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKL-SIL 2750

Query: 782  QREKENLCNLEKK 794
            ++E E      KK
Sbjct: 2751 EKEDETEVQESKK 2763



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 101/519 (19%), Positives = 202/519 (38%), Gaps = 63/519 (12%)

Query: 611  SQELAAMEETRIVILNN-----LEELKQKIKDINDQMDESFRELDMECALLDGEQKSE-- 663
            S+EL   E  + ++L+N     + E K  +  I+++M    +   +  ++ D    S   
Sbjct: 1518 SKELG--EHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMD 1575

Query: 664  -TTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDE 722
             + +LM  +E L+ + +++    +    E  +  +LL     H   +E +Q E + +L E
Sbjct: 1576 ASRQLMLNEEQLEDMRQELVRQYQ----EHQQATELL--RQAHMRQME-RQREDQEQLQE 1628

Query: 723  EKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQ 782
            E + L +QL +  +    N+VS +E++   + +A   +  A RE+     E  N     Q
Sbjct: 1629 EIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREK--LCCELRNSSTQTQ 1686

Query: 783  REKENLCNLEK---KYSSLSGGKGFPVNPNTLKEGYISVNEINE------------PCGN 827
               EN   +E+   K   L   K   V P  L     ++ + N                 
Sbjct: 1687 NGNENQGEVEEQTFKEKELD-RKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAV 1745

Query: 828  STNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGL--YLSDTLPR 885
               +        D  + +   A+ +  S+ ++       EE  +   E +  Y    +PR
Sbjct: 1746 EETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPR 1805

Query: 886  ----------KKTTSSISPHFSSATMGRSITPK-AHLPLGQSNSCGSVLPPSLAAMAKDS 934
                      ++ T        S   G  I P+   L L  S+   + +   L A+++ S
Sbjct: 1806 NDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETS 1865

Query: 935  ESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSD 994
                  +    + M E  RQK E     A+ES           H  + +A + L+++ S 
Sbjct: 1866 SQLEHAKVTQTELMRESFRQKQE-----ATESLKCQEELRERLHE-ESRAREQLAVELSK 1919

Query: 995  SMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEE 1054
            +          D  +   T    +I+E   ++ +   E      +R +E+EA+++ ++EE
Sbjct: 1920 AEGVI------DGYADEKTLFERQIQEKTDIIDRLEQE-LLCASNRLQELEAEQQQIQEE 1972

Query: 1055 KRRREILEKRLQEETS--QRQKLIEKEVKIRERQRAQAR 1091
            +      ++ ++ E    ++Q L E E  ++E+   Q +
Sbjct: 1973 RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011



 Score = 30.8 bits (68), Expect = 8.4
 Identities = 55/260 (21%), Positives = 95/260 (36%), Gaps = 39/260 (15%)

Query: 461  EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 520
            E+ + E+E + LE Q+L           K         + +DV+ +    E    ++E  
Sbjct: 2633 EKNVLEKEKKLLELQKL------LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESG 2686

Query: 521  VFEEALMSPDTRYRCHRKDSLPD-ADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPP 579
             F E            R +S+   A+LAS    ++        + T    L  DL++   
Sbjct: 2687 FFNEL--------EALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRD 2738

Query: 580  PPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQ---KIK 636
              +    K       LSIL K  E  +E Q S++    E   I +  ++        KI 
Sbjct: 2739 HLAEAKEK-------LSILEKEDE--TEVQESKKACMFEPLPIKLSKSIASQTDGTLKIS 2789

Query: 637  DINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDA 696
              N       +   ++  L       E TE      I+     KI ++++         A
Sbjct: 2790 SSNQTPQILVKNAGIQINLQSECSSEEVTE------IISQFTEKIEKMQE------LHAA 2837

Query: 697  DLLDVESKHFEDLEFQQLEH 716
            ++LD+ES+H  + E  + EH
Sbjct: 2838 EILDMESRHISETETLKREH 2857


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
            [Homo sapiens]
          Length = 1354

 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 156/771 (20%), Positives = 309/771 (40%), Gaps = 129/771 (16%)

Query: 437  RERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLST 496
            R  ++ +S++  +D L D  +  +  +L  +++ +L++Q LE    L    T+ D+ +  
Sbjct: 510  RNVENEVSTL--KDQLEDLKKVSQNSQLANEKLSQLQKQ-LEEANDLLR--TESDTAVRL 564

Query: 497  GTTVEDVQKINKELEKL--QLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQ 554
              +  ++ K   +LE L  +L +   + E +    D  Y  ++  ++ +A+    G    
Sbjct: 565  RKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDY--YQLQAILEAERRDRG---- 618

Query: 555  SSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQEL 614
                        + E++ DL        +       E  +L    +  EG  E + +Q++
Sbjct: 619  -----------HDSEMIGDL-------QARITSLQEEVKHLKHNLEKVEG--ERKEAQDM 658

Query: 615  AAMEETRIVILNNLE-ELKQKIKDINDQMDESFRELDMECA-LLDGEQKSETTELMKEKE 672
                E      NNLE +L  K+K +  ++++   E  +  A L D  Q  E  + +   E
Sbjct: 659  LNHSEKE---KNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCE 715

Query: 673  ILDHLN--RKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEH----ESRLDEEKEN 726
            +   L   R+  E  +N V +  K   +LDV+ K  +    Q+LEH    + R+++E +N
Sbjct: 716  MEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQ----QKLEHLTGNKERMEDEVKN 771

Query: 727  LTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKE 786
            LT QL +E    +R ++  + K  A +      +++  +++ + + E   L+      + 
Sbjct: 772  LTLQLEQE--SNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLL------EF 823

Query: 787  NLCNLEKKYSSLSGGKGFPVNPNTLKEGYIS------VNEINEPC--GNSTNLSPSTQFP 838
             L  L K+Y   + G+   +      E Y S      V E+ E     N  NL    +  
Sbjct: 824  ELAQLTKQYRG-NEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQ 882

Query: 839  ADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSS 898
             + + +AT+   A   ++ +S++  R L E +       Y   T   KK  S        
Sbjct: 883  NEKETLATQLDLA--ETKAESEQLARGLLEEQ-------YFELTQESKKAAS-------- 925

Query: 899  ATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEF 958
                + IT K H          S L  + + + KD E  R      +++++E  ++  E 
Sbjct: 926  -RNRQEITDKDHTV--------SRLEEANSMLTKDIEILRR----ENEELTEKMKKAEEE 972

Query: 959  YNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIAR 1018
            Y     E    L +           AF+  ++++  +++T             + + +A 
Sbjct: 973  YKLEKEEEISNLKA-----------AFEK-NINTERTLKTQ------------AVNKLAE 1008

Query: 1019 IEEMERLLKQAHAEKTRLLESREREMEAKKRALE---EEKRRREILEKRLQEETSQRQKL 1075
            I  M R   +   +K    + R++E E +K  LE   E ++  +++ K  +E    + +L
Sbjct: 1009 I--MNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQL 1066

Query: 1076 IEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFL- 1134
            +E+     E Q   A   +    +R +  DL      A          ++ E    G+L 
Sbjct: 1067 VEECAHRNELQMQLASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLS 1126

Query: 1135 IKMGGKIKT--WKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYY 1183
            +   G IK   WKK++ V    K  F  Y D+ + +         I+++++
Sbjct: 1127 VPNRGNIKRYGWKKQYVVVSSKKILF--YNDEQDKEQSNPSMVLDIDKLFH 1175



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 120/630 (19%), Positives = 247/630 (39%), Gaps = 114/630 (18%)

Query: 607  EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQK----S 662
            +E   + +  +EE     +   +E++QK +  N ++D+  +ELD E     G Q+    S
Sbjct: 425  QESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEE-----GNQRRNLES 479

Query: 663  ETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLE-FQQLEHESRLD 721
              +++ KEK +L H   +I E ++    E  K  ++ +  S   + LE  +++   S+L 
Sbjct: 480  TVSQIEKEKMLLQH---RINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLA 536

Query: 722  EEKENLTQQLLREVAEYQR-----------------NIVSRKEKISALKKQANHIVQ--Q 762
             EK +  Q+ L E  +  R                   +S+ E ++   ++ N I++  +
Sbjct: 537  NEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSK 596

Query: 763  AQREQDHF-------------------VKEKNNLIMMLQREKENL-CNLEKKYSSLSGGK 802
            +Q ++D++                   + +    I  LQ E ++L  NLEK        +
Sbjct: 597  SQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQ 656

Query: 803  GFPVNPNTLKEGYISVN--------------EINEPCGNSTNLSPSTQFPADADAVATEP 848
               +N +  ++  + ++              E+NE       L+   Q   +A +VA   
Sbjct: 657  DM-LNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCE 715

Query: 849  ATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPK 908
                L  + +++E     E R  Q ++   + D +  K++   +     +          
Sbjct: 716  MEKKLKEEREARE---KAENRVVQIEKQCSMLD-VDLKQSQQKLEHLTGNKERMEDEVKN 771

Query: 909  AHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNV 968
              L L Q ++   +L   L   A ++++ + L     Q+++     K       A  +  
Sbjct: 772  LTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQ 831

Query: 969  YLNS----FHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMER 1024
            Y  +        D    +Q F TL       ++        + I   +  N+ +I+E++ 
Sbjct: 832  YRGNEGQMRELQDQLEAEQYFSTLYKTQVKELK--------EEIEEKNRENLKKIQELQN 883

Query: 1025 LLKQAHAEKTRLLESREREMEAKKRALEEE-------------KRRREILEK-----RLQ 1066
              K+  A +  L E++    +  +  LEE+             + R+EI +K     RL+
Sbjct: 884  -EKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLE 942

Query: 1067 EETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSI- 1125
            E  S    ++ K+++I  R+  +   LT  +   +E++ L    E +  N+   +  +I 
Sbjct: 943  EANS----MLTKDIEILRRENEE---LTEKMKKAEEEYKLEKEEEIS--NLKAAFEKNIN 993

Query: 1126 TEKTCRGFLIKMGGKIKTWKKRWFVFDRNK 1155
            TE+T +   +    +I   K   F  DR K
Sbjct: 994  TERTLKTQAVNKLAEIMNRKD--FKIDRKK 1021


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 113/552 (20%), Positives = 211/552 (38%), Gaps = 75/552 (13%)

Query: 288  RATENQLTPL-SLPPRNSLGNSKRTKL------GEKDLPHSVIDNDNYLNFSSLSSGALP 340
            +ATE +L  L +L   +S G S+  KL       EK + H  I+     N  S  + ++ 
Sbjct: 721  KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK----NAESSKASSI- 775

Query: 341  YKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGES 400
              T   +G     + L    S     K  L        + F +AS    +   S+     
Sbjct: 776  --TRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE-TV 832

Query: 401  DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERK-----------------SSI 443
            +++      F+  S     +DLE LR+     +   RE+                  + I
Sbjct: 833  NKLHQKEEQFNMLS-----SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEI 887

Query: 444  SSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDV 503
              +SG D+     +   E RL+E+++E L+            + TK +         E+ 
Sbjct: 888  MKMSG-DNSSQLTKMNDELRLKERDVEELQ-----------LKLTKAN---------ENA 926

Query: 504  QKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASF 559
              + K +E + +  E+S  E A    + +    RK S  +  + +    C  L       
Sbjct: 927  SFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERA 986

Query: 560  FTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEE 619
             +   T+++E+L +L +T          A  E+S   +L +  E   +  +++     E+
Sbjct: 987  TSETKTKHEEILQNLQKTLLDTEDKLKGAREENS--GLLQELEELRKQADKAKAAQTAED 1044

Query: 620  TRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNR 679
               ++    +E  + +  + D    + + L  E   L         EL K KE+L   N+
Sbjct: 1045 AMQIMEQMTKEKTETLASLEDTKQTNAK-LQNELDTLKENNLKNVEELNKSKELLTVENQ 1103

Query: 680  KIAELEKNI------VGEKTKDADLLDVES-KHFEDL--EFQQLEHESRLDEEKENLTQQ 730
            K+ E  K I        +K++    L  E+ K  E+L     ++    +L+EE+  L  Q
Sbjct: 1104 KMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQ 1163

Query: 731  LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCN 790
            LL       + I    E+ ++L+K  + I      E+D  +++  N + +L+ E  +  +
Sbjct: 1164 LLEMKKRESKFIKDADEEKASLQKSIS-ITSALLTEKDAELEKLRNEVTVLRGENASAKS 1222

Query: 791  LEKKYSSLSGGK 802
            L     +L   K
Sbjct: 1223 LHSVVQTLESDK 1234



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 202/1068 (18%), Positives = 377/1068 (35%), Gaps = 183/1068 (17%)

Query: 91   QPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSGYPL 150
            Q  PA R+ SPL TS  S  S          S   T  NIP KP  P           P 
Sbjct: 138  QTTPASRATSPLCTSTASMVS----------SSPSTPSNIPQKPSQPAAKE-------PS 180

Query: 151  GRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEG----RKASGSLLAM 206
                  + T   SE    LSE     K     K  D V   G   G       +      
Sbjct: 181  ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240

Query: 207  WNGSSLSDA-GPPPISRSGAASMPSSPK--------QARKMSIQDSLALQPKLTRHKELA 257
            W G  L +  G    + +G       PK        +  K+    +   + K    + + 
Sbjct: 241  WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM 300

Query: 258  SENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKD 317
            +       R  S+SSLS M + + S+              S P R  L     ++   K 
Sbjct: 301  ATTSASLKRSPSASSLSSMSSVASSVS-------------SRPSRTGLLTETSSRYARK- 346

Query: 318  LPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCA 377
                              SG    + +  E   ++   L   A   + R  +  +TS   
Sbjct: 347  -----------------ISGTTALQEALKEKQQHIEQLL---AERDLERAEVAKATSHVG 386

Query: 378  SDDFDQASYVGTNPSHSL-LAGESDRVFATRRNFSCGSVEFDEADLESLRQASG----TP 432
              + + A     +  H L L  + D++           VE      E  R+         
Sbjct: 387  EIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVE 446

Query: 433  QPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 492
            + ++ +    ++++S +  +M+    +++  LR QE+  L R+RLE+         KP  
Sbjct: 447  EESITKGDLEVATVSEKSRIMEL---EKDLALRVQEVAEL-RRRLES--------NKPAG 494

Query: 493  RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD--TRYRCHRKDSLPDADLASCG 550
             +    ++  +Q+I+   EKL+++  +   E   +      R   H+K+           
Sbjct: 495  DVDMSLSL--LQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEI---------- 542

Query: 551  SLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQR 610
                 +    T + ++ +E L           S    A+ E+S +  L K+    +    
Sbjct: 543  ----KALYTATEKLSKENESLK----------SKLEHANKENSDVIALWKSKLETAIASH 588

Query: 611  SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKE 670
             Q   AMEE ++     L     +  ++  Q+++   +   E   L  +Q SE     KE
Sbjct: 589  QQ---AMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKE 645

Query: 671  KEILDHLNRKIAELEKNIVG------EKTKDADLLDVES------------KHFEDLEFQ 712
             E L     K+ + ++N +       +K +D  L+++E             K  E L+ +
Sbjct: 646  MEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAK 705

Query: 713  QLEHESRLDEEKENL--TQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHF 770
              E    +D     L  T++ L ++   ++     K ++  L++Q    ++ A+++  H 
Sbjct: 706  CNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQ----LEAAEKQIKHL 761

Query: 771  VKEKN-------NLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINE 823
              EKN       ++   LQ  +  L NL++  S +S      V     KE  I   +  E
Sbjct: 762  EIEKNAESSKASSITRELQGRELKLTNLQENLSEVS-----QVKETLEKELQILKEKFAE 816

Query: 824  PCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEH-------FRSLEERKKQ---H 873
                + ++  S Q   +      E    + +   + +E+       FR  +ER++Q    
Sbjct: 817  ASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 876

Query: 874  KEGLY--LSDTLPRKKTTSS-ISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAM 930
            KE L   +++ +      SS ++       +      +  L L ++N   S L  S+  M
Sbjct: 877  KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 936

Query: 931  AKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSL 990
               +E        + Q+ ++ H ++ +   R  S+    + + H      K + ++  + 
Sbjct: 937  TVKAEQ-------SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR-YERATS 988

Query: 991  DSSDSMETSISAC------SPDNISSASTSNIARIEEMERLLKQAHAEKT--------RL 1036
            ++    E  +         + D +  A   N   ++E+E L KQA   K         ++
Sbjct: 989  ETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQI 1048

Query: 1037 LESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRE 1084
            +E   +E      +LE+ K+    L+  L        K +E+  K +E
Sbjct: 1049 MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKE 1096



 Score = 39.3 bits (90), Expect = 0.023
 Identities = 112/563 (19%), Positives = 224/563 (39%), Gaps = 99/563 (17%)

Query: 605  ISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDG----EQ 660
            +SE+ R  EL   E+   + +  + EL+++++      ++   ++DM  +LL      ++
Sbjct: 460  VSEKSRIMEL---EKDLALRVQEVAELRRRLES-----NKPAGDVDMSLSLLQEISSLQE 511

Query: 661  KSETTELMKEKEIL---DHLNRKIAELEKNIVGEKTKDADL----------LDVESKHFE 707
            K E T    ++EI    +H   +    +K I    T    L          L+  +K   
Sbjct: 512  KLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENS 571

Query: 708  D--------LEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI 759
            D        LE     H+  ++E K + ++ L  E AE+       K +I  ++    H 
Sbjct: 572  DVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEF----AELKTQIEKMRLDYQHE 627

Query: 760  VQQAQREQDH----FVKEKNNL---IMMLQREKENLCNLEKKYSSLSGGKGFPV-----N 807
            ++  Q +QD       KE   L   +M + +EKEN  +LE   S L   +   +      
Sbjct: 628  IENLQNQQDSERAAHAKEMEALRAKLMKVIKEKEN--SLEAIRSKLDKAEDQHLVEMEDT 685

Query: 808  PNTLKEGYISVNEIN---EPCGNSTNLSPS--TQFPADADAVATEPATAVLASQPQS--K 860
             N L+E  I V E+      C   T +  +  +Q  A  + +    A    +S+ +S  K
Sbjct: 686  LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMK 745

Query: 861  EHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSIT-PKAHLPLGQSNSC 919
            +  + LE  +KQ K           K   SS +   +    GR +        L + +  
Sbjct: 746  KLRQQLEAAEKQIKH------LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQV 799

Query: 920  GSVLPPSLAAM----AKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHY 975
               L   L  +    A+ SE    ++    + +++ H QK E +N  +S+      +   
Sbjct: 800  KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLAD 858

Query: 976  PDHSY--KDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEK 1033
             +  +  KD+  + L + + + +E  I+      +S  ++S + ++ +  RL        
Sbjct: 859  MEAKFREKDEREEQL-IKAKEKLENDIAEIM--KMSGDNSSQLTKMNDELRL-------- 907

Query: 1034 TRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPL 1093
                  +ER++E  +  L +       L+K +++ T + ++  ++  K  E ++ +    
Sbjct: 908  ------KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE---- 957

Query: 1094 TRYLPVRKEDFDLRSHVETAGHN 1116
                 + ++  DL   +ET+ HN
Sbjct: 958  -----LERKLSDLEKKMETS-HN 974



 Score = 34.3 bits (77), Expect = 0.76
 Identities = 27/104 (25%), Positives = 52/104 (50%), Gaps = 24/104 (23%)

Query: 1012 STSNIARIEEMERLLKQAHAEKTRLLESR-----------EREMEAKKRALEEEKRRREI 1060
            +TS++  IE+   L +  H +    LE++           +RE       LEEEKR+ E 
Sbjct: 381  ATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVED 440

Query: 1061 LEKRLQEET-----------SQRQKL--IEKEVKIRERQRAQAR 1091
            L+ R++EE+           S++ ++  +EK++ +R ++ A+ R
Sbjct: 441  LQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELR 484


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 113/552 (20%), Positives = 211/552 (38%), Gaps = 75/552 (13%)

Query: 288  RATENQLTPL-SLPPRNSLGNSKRTKL------GEKDLPHSVIDNDNYLNFSSLSSGALP 340
            +ATE +L  L +L   +S G S+  KL       EK + H  I+     N  S  + ++ 
Sbjct: 756  KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK----NAESSKASSI- 810

Query: 341  YKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGES 400
              T   +G     + L    S     K  L        + F +AS    +   S+     
Sbjct: 811  --TRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE-TV 867

Query: 401  DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERK-----------------SSI 443
            +++      F+  S     +DLE LR+     +   RE+                  + I
Sbjct: 868  NKLHQKEEQFNMLS-----SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEI 922

Query: 444  SSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDV 503
              +SG D+     +   E RL+E+++E L+            + TK +         E+ 
Sbjct: 923  MKMSG-DNSSQLTKMNDELRLKERDVEELQ-----------LKLTKAN---------ENA 961

Query: 504  QKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASF 559
              + K +E + +  E+S  E A    + +    RK S  +  + +    C  L       
Sbjct: 962  SFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERA 1021

Query: 560  FTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEE 619
             +   T+++E+L +L +T          A  E+S   +L +  E   +  +++     E+
Sbjct: 1022 TSETKTKHEEILQNLQKTLLDTEDKLKGAREENS--GLLQELEELRKQADKAKAAQTAED 1079

Query: 620  TRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNR 679
               ++    +E  + +  + D    + + L  E   L         EL K KE+L   N+
Sbjct: 1080 AMQIMEQMTKEKTETLASLEDTKQTNAK-LQNELDTLKENNLKNVEELNKSKELLTVENQ 1138

Query: 680  KIAELEKNI------VGEKTKDADLLDVES-KHFEDL--EFQQLEHESRLDEEKENLTQQ 730
            K+ E  K I        +K++    L  E+ K  E+L     ++    +L+EE+  L  Q
Sbjct: 1139 KMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQ 1198

Query: 731  LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCN 790
            LL       + I    E+ ++L+K  + I      E+D  +++  N + +L+ E  +  +
Sbjct: 1199 LLEMKKRESKFIKDADEEKASLQKSIS-ITSALLTEKDAELEKLRNEVTVLRGENASAKS 1257

Query: 791  LEKKYSSLSGGK 802
            L     +L   K
Sbjct: 1258 LHSVVQTLESDK 1269



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 207/1090 (18%), Positives = 379/1090 (34%), Gaps = 192/1090 (17%)

Query: 91   QPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSGYPL 150
            Q  PA R+ SPL TS  S  S          S   T  NIP KP  P           P 
Sbjct: 138  QTTPASRATSPLCTSTASMVS----------SSPSTPSNIPQKPSQPAAKE-------PS 180

Query: 151  GRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEG----RKASGSLLAM 206
                  + T   SE    LSE     K     K  D V   G   G       +      
Sbjct: 181  ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240

Query: 207  WNGSSLSDA-GPPPISRSGAASMPSSPK--------QARKMSIQDSLALQPKLTRHKELA 257
            W G  L +  G    + +G       PK        +  K+    +   + K    + + 
Sbjct: 241  WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM 300

Query: 258  SENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKD 317
            +       R  S+SSLS M + + S+              S P R  L     ++   K 
Sbjct: 301  ATTSASLKRSPSASSLSSMSSVASSVS-------------SRPSRTGLLTETSSRYARK- 346

Query: 318  LPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCA 377
                              SG    + +  E   ++   L                    A
Sbjct: 347  -----------------ISGTTALQEALKEKQQHIEQLL--------------------A 369

Query: 378  SDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALR 437
              D ++A  V    SH    GE ++  A  R+     V   EA ++ LR      + A R
Sbjct: 370  ERDLERAE-VAKATSH---VGEIEQELALARDGHDQHVLELEAKMDQLRTMV---EAADR 422

Query: 438  ERKSSISSISG-RDDLMDYHRRQREERLREQEME---RLERQRLETI-LSLCAEYTKPDS 492
            E+   ++ +   +  + D   R  EE + + ++E   +LE  R++ +  SL  E TK D 
Sbjct: 423  EKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKAD- 481

Query: 493  RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
            +L        V  ++++   ++L  + ++  + +     R   ++     D  L+    +
Sbjct: 482  KLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEI 541

Query: 553  SQSSASFFTPRSTRNDELLS------------------------DLTRTPPPPSSTFPKA 588
            S         R+    E+ S                         L++      S    A
Sbjct: 542  SSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHA 601

Query: 589  SSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRE 648
            + E+S +  L K+    +     Q   AMEE ++     L     +  ++  Q+++   +
Sbjct: 602  NKENSDVIALWKSKLETAIASHQQ---AMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 658

Query: 649  LDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVG------EKTKDADLLDVE 702
               E   L  +Q SE     KE E L     K+ + ++N +       +K +D  L+++E
Sbjct: 659  YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME 718

Query: 703  S------------KHFEDLEFQQLEHESRLDEEKENL--TQQLLREVAEYQRNIVSRKEK 748
                         K  E L+ +  E    +D     L  T++ L ++   ++     K +
Sbjct: 719  DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 778

Query: 749  ISALKKQANHIVQQAQREQDHFVKEKN-------NLIMMLQREKENLCNLEKKYSSLSGG 801
            +  L++Q    ++ A+++  H   EKN       ++   LQ  +  L NL++  S +S  
Sbjct: 779  MKKLRQQ----LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVS-- 832

Query: 802  KGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKE 861
                V     KE  I   +  E    + ++  S Q   +      E    + +   + +E
Sbjct: 833  ---QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE 889

Query: 862  H-------FRSLEERKKQ---HKEGLY--LSDTLPRKKTTSS-ISPHFSSATMGRSITPK 908
            +       FR  +ER++Q    KE L   +++ +      SS ++       +      +
Sbjct: 890  NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 949

Query: 909  AHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNV 968
              L L ++N   S L  S+  M   +E        + Q+ ++ H ++ +   R  S+   
Sbjct: 950  LQLKLTKANENASFLQKSIEDMTVKAEQ-------SQQEAAKKHEEEKKELERKLSDLEK 1002

Query: 969  YLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISAC------SPDNISSASTSNIARIEEM 1022
             + + H      K + ++  + ++    E  +         + D +  A   N   ++E+
Sbjct: 1003 KMETSHNQCQELKAR-YERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQEL 1061

Query: 1023 ERLLKQAHAEKT--------RLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1074
            E L KQA   K         +++E   +E      +LE+ K+    L+  L        K
Sbjct: 1062 EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK 1121

Query: 1075 LIEKEVKIRE 1084
             +E+  K +E
Sbjct: 1122 NVEELNKSKE 1131



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 141/725 (19%), Positives = 275/725 (37%), Gaps = 94/725 (12%)

Query: 426  RQASGTP--QPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLERQRLETIL 481
            R+ SGT   Q AL+E++  I  +    DL      +    + E  QE+        + +L
Sbjct: 345  RKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVL 404

Query: 482  SLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 541
             L A+      +L T     D +K+  EL   QL +E+   E      D ++R   ++S+
Sbjct: 405  ELEAKM----DQLRTMVEAADREKV--ELLN-QLEEEKRKVE------DLQFRVE-EESI 450

Query: 542  PDADLASCGSLSQSSASFFTP----RSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSI 597
               DL +   L  +             T+ D+L  +L  T     S   +       L++
Sbjct: 451  TKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLAL 510

Query: 598  LPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLD 657
              +    +     S + A   +  + +L  +  L++K++            L       +
Sbjct: 511  RVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGARE 570

Query: 658  GEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHE 717
               + E   L    E L   N  +    ++   E +      DV +     LE     H+
Sbjct: 571  ETHQKEIKALYTATEKLSKENESLKSKLEHANKENS------DVIALWKSKLETAIASHQ 624

Query: 718  SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDH----FVKE 773
              ++E K + ++ L  E AE+       K +I  ++    H ++  Q +QD       KE
Sbjct: 625  QAMEELKVSFSKGLGTETAEF----AELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKE 680

Query: 774  KNNL---IMMLQREKENLCNLEKKYSSLSGGKGFPV-----NPNTLKEGYISVNEIN--- 822
               L   +M + +EKEN  +LE   S L   +   +       N L+E  I V E+    
Sbjct: 681  MEALRAKLMKVIKEKEN--SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 738

Query: 823  EPCGNSTNLSPS--TQFPADADAVATEPATAVLASQPQS--KEHFRSLEERKKQHKEGLY 878
              C   T +  +  +Q  A  + +    A    +S+ +S  K+  + LE  +KQ K    
Sbjct: 739  AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKH--- 795

Query: 879  LSDTLPRKKTTSSISPHFSSATMGRSIT-PKAHLPLGQSNSCGSVLPPSLAAM----AKD 933
                   K   SS +   +    GR +        L + +     L   L  +    A+ 
Sbjct: 796  ---LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 852

Query: 934  SESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSY--KDQAFDTLSLD 991
            SE    ++    + +++ H QK E +N  +S+      +    +  +  KD+  + L + 
Sbjct: 853  SEEAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQL-IK 910

Query: 992  SSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRAL 1051
            + + +E  I+      +S  ++S + ++ +  RL              +ER++E  +  L
Sbjct: 911  AKEKLENDIAEIM--KMSGDNSSQLTKMNDELRL--------------KERDVEELQLKL 954

Query: 1052 EEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVE 1111
             +       L+K +++ T + ++  ++  K  E ++ +         + ++  DL   +E
Sbjct: 955  TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE---------LERKLSDLEKKME 1005

Query: 1112 TAGHN 1116
            T+ HN
Sbjct: 1006 TS-HN 1009


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 133/695 (19%), Positives = 280/695 (40%), Gaps = 112/695 (16%)

Query: 451  DLMDYHRRQR--EERLREQEMERLERQRLETILS------------LCAEYTKPDSRLST 496
            +LM+ H      + RLR  E++R+E Q    +L             L A   +  ++ S 
Sbjct: 1314 ELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASA 1373

Query: 497  GTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSS 556
               +E+  +  +   KL+  + ES           R R        +  +A   +L ++ 
Sbjct: 1374 AGILEEDLRTARSALKLKNEEVES----------ERERAQALQEQGELKVAQGKALQENL 1423

Query: 557  ASFFTPRSTRNDEL------LSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQR 610
            A      + R +E+      + +L +          KA+ E   L +  +  E   ++++
Sbjct: 1424 ALLTQTLAEREEEVETLRGQIQELEK-----QREMQKAALELLSLDLKKRNQEVDLQQEQ 1478

Query: 611  SQELAAMEETRIVILNNLEELKQKIKDINDQMD---ESFRELDMECALLDGEQKSETTEL 667
             QEL   E+ R V    LE L   +++   ++    E  REL+ +        + +  EL
Sbjct: 1479 IQEL---EKCRSV----LEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531

Query: 668  MKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQL---EHESRLDEEK 724
             K+ ++++    ++ +L+K +V   T +   L++E  H + +E QQ    E E + + ++
Sbjct: 1532 EKKDQMIESQRGQVQDLKKQLV---TLECLALELEENHHK-MECQQKLIKELEGQRETQR 1587

Query: 725  ENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE 784
              LT   L ++ E  + + ++  +I  L+  +  + ++ Q E+D  VK +   I  LQR+
Sbjct: 1588 VALTHLTL-DLEERSQELQAQSSQIHDLESHSTVLARELQ-ERDQEVKSQREQIEELQRQ 1645

Query: 785  KENLC-NLEKKYSSL------------SGGKGFPVNPNTLKEGYISVNEINEPCGNSTNL 831
            KE+L  +LE++   L               +   +    L++  +S+ E          L
Sbjct: 1646 KEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQL 1705

Query: 832  ----SPSTQFPADADAVATEPATAVLASQPQ----SKEHFRSLEERKKQHKEGLYLSDTL 883
                +   + P+ A   + E    +L  + +     +EH   L+E K Q ++ L     L
Sbjct: 1706 MQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQL---QGL 1762

Query: 884  PRKKTTSSI---SPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRML 940
             RK   +S+           + + +         +  S  S L  +  A+A+  +    L
Sbjct: 1763 HRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEAL 1822

Query: 941  RGYNHQQMSEGH----RQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSM 996
            +    QQ ++G     ++K++       ++++ L   H     +K+QA     L+   ++
Sbjct: 1823 Q--QEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQA---RRLEEELAV 1877

Query: 997  ETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKR 1056
            E                    R++ +E +L    AE       +E+ + A ++   E+ +
Sbjct: 1878 EG------------------RRVQALEEVLGDLRAES----REQEKALLALQQQCAEQAQ 1915

Query: 1057 RREILEKRLQEETSQRQKLIEKEVKIRERQRAQAR 1091
              E+  + LQ+   Q Q ++++  +  E  RA+++
Sbjct: 1916 EHEVETRALQDSWLQAQAVLKERDQELEALRAESQ 1950



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 160/762 (20%), Positives = 295/762 (38%), Gaps = 129/762 (16%)

Query: 407  RRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS-------SISGRDDLMDYHRRQ 459
            +R     ++E    DL+   Q     Q  ++E +   S       ++  R+  +   R Q
Sbjct: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509

Query: 460  REERLREQEMER--LERQRLETILSLCAEYTKPDSRL-STGTTVEDVQKINKELEKLQLS 516
              E  +++E +R  LE Q LE          K D  + S    V+D++K    LE L L 
Sbjct: 1510 IRELEKDRETQRNVLEHQLLEL--------EKKDQMIESQRGQVQDLKKQLVTLECLALE 1561

Query: 517  DEESVF----EEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLS 572
             EE+      ++ L+      R  ++ +L    L     L + S      +S++  +L S
Sbjct: 1562 LEENHHKMECQQKLIKELEGQRETQRVALTHLTL----DLEERSQEL-QAQSSQIHDLES 1616

Query: 573  DLTRTPPPPSSTFPKASSESSYLSILPKTPEGISE--EQRSQELAAMEETRIVILNNLEE 630
              T           +  S+   +  L +  E +++  E+R QEL   +E RI +L +   
Sbjct: 1617 HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKE-RIQVLEDQRT 1675

Query: 631  LKQKIKDIN-DQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIV 689
             + KI + + +Q+  S RE   E       Q+    E  +E +      R   E  K I+
Sbjct: 1676 RQTKILEEDLEQIKLSLRERGRELTT----QRQLMQERAEEGKGPSKAQRGSLEHMKLIL 1731

Query: 690  GEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL---REVAEYQRNIVSRK 746
             +K K+ +               Q EH   L E K+ L QQL    R+V E    +  R+
Sbjct: 1732 RDKEKEVEC--------------QQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQRE 1777

Query: 747  EKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPV 806
            ++I  L++Q     +Q + ++     + +     L +  + L  L+++     G +    
Sbjct: 1778 QEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQE---- 1833

Query: 807  NPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ----PQSKEH 862
                +KE                         ADA   A E A   L  +       KE 
Sbjct: 1834 --ERVKE------------------------KADALQGALEQAHMTLKERHGELQDHKEQ 1867

Query: 863  FRSLEE------RKKQHKE---GLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPL 913
             R LEE      R+ Q  E   G   +++  ++K   ++    +       +  +A    
Sbjct: 1868 ARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDS 1927

Query: 914  G-QSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNS 972
              Q+ +        L A+  +S+S R      HQ+  E  R ++E       +++  L  
Sbjct: 1928 WLQAQAVLKERDQELEALRAESQSSR------HQE--EAARARAEALQEALGKAHAALQG 1979

Query: 973  FHYPDHSYKDQAFDTLSLDSSDS-METSISACSPDNISSASTSNIA---------RIEEM 1022
                +    +QA  + SL++S + ++ S+ AC   +        I          R +E 
Sbjct: 1980 ---KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQED 2036

Query: 1023 ERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK- 1081
             + L+QA A++   L    R  + +++ LE+   +R + E  +QE+ +  Q+  E+E++ 
Sbjct: 2037 VQQLQQALAQRDEEL----RHQQEREQLLEKSLAQR-VQENMIQEKQNLGQEREEEEIRG 2091

Query: 1082 ----IRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDT 1119
                +RE Q   A+     L +R  +   R+++E   H+  T
Sbjct: 2092 LHQSVRELQLTLAQKEQEILELR--ETQQRNNLEALPHSHKT 2131



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 147/723 (20%), Positives = 277/723 (38%), Gaps = 126/723 (17%)

Query: 422  LESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQR---LE 478
            LESL +     +  L+E+++ + +I  +    +  R Q E  L + ++E  E++R   LE
Sbjct: 877  LESLEREKMELEMRLKEQQTEMEAIQAQ---REEERTQAESALCQMQLET-EKERVSLLE 932

Query: 479  TILSLCAEYTKPDSRLSTGTTVEDVQKINKE----LEKLQLSDEESVFEEALMSPDTRYR 534
            T+L    E      +L        VQK+ ++    + + QL + +   +EA        R
Sbjct: 933  TLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA-------R 985

Query: 535  CHRKDSLPDADLASCGSLSQSSASFFTPR---STRNDELLSDLTRTPPPPSSTFPKASSE 591
             HR D           +L + S+S    +     + ++L S L            +   +
Sbjct: 986  QHRDD---------LAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEK 1036

Query: 592  SSYLSILPKTPEGISEEQRSQELAAME-ETRIVILNNLEELKQK-IKDINDQMDESFREL 649
                    +  + +  E+ S  L+ ME E R+++L   + ++Q+ +  +   M E+    
Sbjct: 1037 LRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEA---- 1092

Query: 650  DMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDL 709
                    GEQK    EL  + E+L                 K K+AD L  E++  E+L
Sbjct: 1093 -------QGEQK----ELSAQMELLRQ-------------EVKEKEADFLAQEAQLLEEL 1128

Query: 710  EFQQLEHE---SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 766
            E   +  +   + L  ++    Q  LR      R+  S+ E ++A ++  N    QAQ  
Sbjct: 1129 EASHITEQQLRASLWAQEAKAAQLQLR-----LRSTESQLEALAAEQQPGNQAQAQAQLA 1183

Query: 767  QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 826
                     +L   LQ+   ++C    + S   GG   P           SV  +     
Sbjct: 1184 ---------SLYSALQQALGSVCESRPELS--GGGDSAP-----------SVWGLEPDQN 1221

Query: 827  NSTNLSPS----TQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDT 882
             + +L       T   A+A A A       L    Q+++  R   ++ ++      L+DT
Sbjct: 1222 GARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEER-----LTDT 1276

Query: 883  LPRKKTTSSISPHFSSATMGRSITPKAHLPL---GQSNSCGSVLPPSLAAMAKDSESRRM 939
               K        H     + R ++          G+ NS  S L      MA  S   R+
Sbjct: 1277 EAEKSQV-----HTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMA--SLQSRL 1329

Query: 940  LRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETS 999
             R    +  ++G R+  +     A++ N+     H      + +A  + +    + + T+
Sbjct: 1330 RRAELQRMEAQGERELLQ-----AAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTA 1384

Query: 1000 ISACSPDNISSASTSNIARIEEMERLLKQAHAEK--------TRLLESREREMEAKKRAL 1051
             SA    N    S    A+  + +  LK A  +         T+ L  RE E+E  +  +
Sbjct: 1385 RSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQI 1444

Query: 1052 EEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQ---RAQARPLTRYLPVRKEDFDLRS 1108
            +E +++RE ++K   E  S   K   +EV +++ Q     + R +  +LP+  ++ + + 
Sbjct: 1445 QELEKQRE-MQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKL 1503

Query: 1109 HVE 1111
             V+
Sbjct: 1504 TVQ 1506



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 90/529 (17%), Positives = 214/529 (40%), Gaps = 57/529 (10%)

Query: 607  EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTE 666
            +++ ++ L ++E  ++ +   L+E + +++ I  Q +E   + +     +  E + E   
Sbjct: 870  QQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVS 929

Query: 667  LMK-----EKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLD 721
            L++     +KE+ D  ++++  L +++  +K K+ +   +     ++ + +  E   +  
Sbjct: 930  LLETLLQTQKELAD-ASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHR 988

Query: 722  EEKENLTQQ---LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLI 778
            ++   L ++   LL++  + Q+ +   K ++ A +  +  +V+Q  +E+    +E N + 
Sbjct: 989  DDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA-QDDSQRLVEQEVQEKLRETQEYNRIQ 1047

Query: 779  MMLQREKEN--LCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQ 836
              L+REK +  L  +EK+   L   +   +    L        ++ E  G    LS   +
Sbjct: 1048 KELEREKASLTLSLMEKEQRLLVLQEADSIRQQELS---ALRQDMQEAQGEQKELSAQME 1104

Query: 837  FPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDT------LPRKKTTS 890
                      E     LA + Q  E   +    ++Q +  L+  +       L  + T S
Sbjct: 1105 LLRQE---VKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTES 1161

Query: 891  SISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSE 950
             +    +    G     +A L      S  S L  +L ++    ESR  L G      S 
Sbjct: 1162 QLEALAAEQQPGNQAQAQAQLA-----SLYSALQQALGSVC---ESRPELSGGGDSAPSV 1213

Query: 951  GHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISS 1010
               +  +   R+  +    L +                   S++++ +++     D   +
Sbjct: 1214 WGLEPDQNGARSLFKRGPLLTAL------------------SAEAVASALHKLHQDLWKT 1255

Query: 1011 ASTSNIAR--IEEMERLLKQAHAEKTRL---LESREREMEAKKRALEEEKRRREILEKRL 1065
              T ++ R  ++++E  L    AEK+++   L+  +R++   +    + + ++  LE  L
Sbjct: 1256 QQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESEL 1315

Query: 1066 QEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR-SHVETA 1113
              E  +    ++  ++  E QR +A+     L   KE+   +  H++ A
Sbjct: 1316 M-ELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAA 1363



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 127/703 (18%), Positives = 262/703 (37%), Gaps = 74/703 (10%)

Query: 444  SSISGRDDLMDYHRRQREERLRE-QEMERLERQRLETILSLCAEYTKPDSRLSTGTTVED 502
            S +  +DD      ++ +E+LRE QE  R++++      SL     + + RL      + 
Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADS 1076

Query: 503  VQKINKELEKLQLSDEESVFEEALMSPDTRY-RCHRKDSLPDADLASCGSLSQSSASFFT 561
            +++  +EL  L+   +E+  E+  +S      R   K+   D        L +  AS  T
Sbjct: 1077 IRQ--QELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHIT 1134

Query: 562  PRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETR 621
             +  R     + L       +    +  S  S L  L    +  ++ Q   +LA++    
Sbjct: 1135 EQQLR-----ASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSAL 1189

Query: 622  IVILNNLEELKQKIKDINDQMDESF---------RELDMECALLDGEQKSETT------- 665
               L ++ E + ++    D     +         R L     LL                
Sbjct: 1190 QQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249

Query: 666  -ELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQ--QLEHESRLDE 722
             +L K ++  D L  ++ +LE+ +   + + + +        +DL+ Q  Q + E    E
Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQV----HTELQDLQRQLSQNQEEKSKWE 1305

Query: 723  EKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQ 782
             K+N  +  L E+ E   ++ SR  +    + +A     Q +RE     KE     +  Q
Sbjct: 1306 GKQNSLESELMELHETMASLQSRLRRAELQRMEA-----QGERELLQAAKEN----LTAQ 1356

Query: 783  REKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPAD-- 840
             E      +E +  + + G    +    L+    ++   NE   +    + + Q   +  
Sbjct: 1357 VEHLQAAVVEARAQASAAG----ILEEDLRTARSALKLKNEEVESERERAQALQEQGELK 1412

Query: 841  -ADAVATEPATAVLASQPQSKEH--------FRSLEERKKQHKEGLYLS--DTLPRKKTT 889
             A   A +   A+L      +E          + LE++++  K  L L   D   R +  
Sbjct: 1413 VAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEV 1472

Query: 890  SSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRR------MLRGY 943
                         RS+     + + +     +V    +  + KD E++R      +L   
Sbjct: 1473 DLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELE 1532

Query: 944  NHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISAC 1003
               QM E   Q+ +  +       +   +    ++ +K +    L  +     ET   A 
Sbjct: 1533 KKDQMIES--QRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVAL 1590

Query: 1004 SPDNISSASTSNIARIEEMERLLKQAHAEK-TRLLESREREMEAKKRALEEEKRRREILE 1062
            +   +     S   + +  +    ++H+    R L+ R++E+++++  +EE +R++E L 
Sbjct: 1591 THLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLT 1650

Query: 1063 KRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFD 1105
            + L E   Q   L ++ +++ E QR      TR   + +ED +
Sbjct: 1651 QDL-ERRDQELMLQKERIQVLEDQR------TRQTKILEEDLE 1686



 Score = 37.4 bits (85), Expect = 0.089
 Identities = 126/662 (19%), Positives = 257/662 (38%), Gaps = 90/662 (13%)

Query: 440  KSSISSISGRDDLMDYHRRQREERLR--EQEMERLERQRLETILSL-CAEYTKPDSRLST 496
            +  + S+S   +L+   R +  ++L   EQE  RL R  +E  L    A+  K + +   
Sbjct: 455  QGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL 514

Query: 497  GTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSS 556
               V + +++ + L  L+    ES+ E   +          +++L  + L   G L +  
Sbjct: 515  HLAVRERERLQEMLMGLEAKQSESLSELITL----------REALESSHLE--GELLRQE 562

Query: 557  ASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAA 616
             +  T    R ++ +++L+ +     +      + +  LS L +    + +   +Q+L  
Sbjct: 563  QTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEAL-ALDKVGLNQQLLQ 621

Query: 617  MEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDH 676
            +EE    + + +E  +Q    +   + E+ +  +   AL +     E  +L K +E    
Sbjct: 622  LEEENQSVCSRMEAAEQARNALQVDLAEAEKRRE---ALWEKNTHLEA-QLQKAEEAGAE 677

Query: 677  LNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVA 736
            L   + ++++    EK +    L  ES+H ++    QLE   +L +E +   + L R V 
Sbjct: 678  LQADLRDIQE----EKEEIQKKLS-ESRHQQEAATTQLE---QLHQEAKRQEEVLARAVQ 729

Query: 737  EYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYS 796
            E        KE +   K      +Q  +R++    ++   L    +  + +L   +++ S
Sbjct: 730  E--------KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNS 781

Query: 797  SLSGGKG-FPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLAS 855
             +   KG   V   T+ +    V +    C      +  +Q   + DA A + A A    
Sbjct: 782  VIEVTKGQLEVQIQTVTQAK-EVIQGEVRCLKLELDTERSQAEQERDAAARQLAQA---- 836

Query: 856  QPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQ 915
                +E   +LE++K  H++ +       R+K     S H                    
Sbjct: 837  ---EQEGKTALEQQKAAHEKEV----NQLREKWEKERSWHQQE----------------- 872

Query: 916  SNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHY 975
                   L  +L ++ ++     M       +M     Q+ E   RT +ES   L     
Sbjct: 873  -------LAKALESLEREKMELEMRLKEQQTEMEAIQAQREE--ERTQAES--ALCQMQL 921

Query: 976  PDHSYKDQAFDTL------SLDSSDSMETSISACSPDNISSASTSNI--ARIEEMERLLK 1027
                 +    +TL        D+S  +E          +    T+ I   +++E +R LK
Sbjct: 922  ETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELK 981

Query: 1028 Q-AHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEV--KIRE 1084
            + A   +  L   +E      +  ++ +K+  ++  + + ++ SQR  L+E+EV  K+RE
Sbjct: 982  EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQR--LVEQEVQEKLRE 1039

Query: 1085 RQ 1086
             Q
Sbjct: 1040 TQ 1041



 Score = 35.4 bits (80), Expect = 0.34
 Identities = 92/496 (18%), Positives = 190/496 (38%), Gaps = 70/496 (14%)

Query: 609  QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL---DMECALLDGEQKSETT 665
            QR QE+  +++    +    E+ + K + +  Q+DE+ R L   D E   L  EQ+    
Sbjct: 1775 QREQEIVVLQQQ---LQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQG 1831

Query: 666  ELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKE 725
            +  + KE  D L      LE+  +  K +  +L D    H E  + ++LE E  ++  + 
Sbjct: 1832 QEERVKEKADALQ---GALEQAHMTLKERHGELQD----HKE--QARRLEEELAVEGRRV 1882

Query: 726  NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE----QDHFVKEKNNLIMML 781
               +++L ++    R    +++ + AL++Q     Q+ + E    QD +++ +    ++ 
Sbjct: 1883 QALEEVLGDLRAESR---EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQ---AVLK 1936

Query: 782  QREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADA 841
            +R++E      +  SS    +        L+E     +   +  G   +L    +     
Sbjct: 1937 ERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQ--GKEQHLLEQAELSRSL 1994

Query: 842  DAVATEPATAVLASQPQSK--EHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSA 899
            +A       ++ A Q  S+  E    ++E + Q ++  Y  D    ++  +         
Sbjct: 1995 EASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQ 2054

Query: 900  TMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFY 959
                 +  K+     Q N        +L    ++ E R + +     Q++   +++    
Sbjct: 2055 QEREQLLEKSLAQRVQENMIQE--KQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILE 2112

Query: 960  NRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARI 1019
             R   +     N+     HS+K    +  SL   DS+E  +                   
Sbjct: 2113 LRETQQR----NNLEALPHSHKTSPMEEQSL-KLDSLEPRLQ------------------ 2149

Query: 1020 EEMERLLKQAHAEKTRLLESREREME-----AKKRA-----------LEEEKRRREILEK 1063
             E+ERL       + R +E RE+  +     A+ +A           L+     R+  ++
Sbjct: 2150 RELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQ 2209

Query: 1064 RLQEETSQRQKLIEKE 1079
            RLQ+E    ++ +EKE
Sbjct: 2210 RLQDELELTRRALEKE 2225


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 129/696 (18%), Positives = 264/696 (37%), Gaps = 102/696 (14%)

Query: 433  QPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEY----T 488
            Q + R  K   S+    DDL+    RQ EE++ +       ++RL+T  S   +Y    T
Sbjct: 918  QSSQRTGKGQPSNKEDVDDLVS-QLRQTEEQVNDL------KERLKTSTSNVEQYQAMVT 970

Query: 489  KPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS 548
              +  L+    V +  + N E+   + ++ ++  E+ LM  +       K  L D    +
Sbjct: 971  SLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKE-----KQELQDDKRRA 1025

Query: 549  CGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEE 608
              S+ Q  +      S+  +E+   L R     S+       + +      +    +  +
Sbjct: 1026 IESMEQQLSELKKTLSSVQNEVQEALQRASTALSN------EQQARRDCQEQAKIAVEAQ 1079

Query: 609  QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELD---MECALLDGEQ----K 661
             + +    +    +  L   +E   K+  +   ++E+ ++ +   +EC     E+    K
Sbjct: 1080 NKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLK 1139

Query: 662  SETTELMKEKEILDHLNRK------------IAELEKNIVG--------EKTKDADLLDV 701
             E ++ +   E L+  NR             +A +++ + G        E      +L++
Sbjct: 1140 DEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEI 1199

Query: 702  -----ESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKK-Q 755
                   K   +  F+  + ES    ++  L +   RE+ E Q ++ + +EK+    K  
Sbjct: 1200 LRFIRREKEIAETRFEVAQVESLRYRQRVELLE---RELQELQDSLNAEREKVQVTAKTM 1256

Query: 756  ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGY 815
            A H     + E  + V E N    ML+ EKE L   E+    +            L+   
Sbjct: 1257 AQHEELMKKTETMNVVMETNK---MLREEKERL---EQDLQQMQA------KVRKLELDI 1304

Query: 816  ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ---PQSKEHFRSLEERKKQ 872
            + + E N      + +  + +   + D    +     L SQ   P ++E+ + L E++  
Sbjct: 1305 LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVH 1364

Query: 873  HKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAK 932
             K    L++ + R K  + I+   +S T  +++       L +  +    +   L A   
Sbjct: 1365 TKRIQQLTEEIGRLK--AEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII 1422

Query: 933  DSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDS 992
            D + +        Q    G R K+++    A +                D+  +T +  S
Sbjct: 1423 DIQEKVKTIT---QVKKIGRRYKTQYEELKAQQ----------------DKVMETSAQSS 1463

Query: 993  SDSMETSISACS----PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKK 1048
             D  E  +S        + ++ A T + +   ++E L K    ++T     +E+ ++ + 
Sbjct: 1464 GDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQS 1523

Query: 1049 RALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRE 1084
                E  R R+ L+ R  +E   RQ++ EKE K R+
Sbjct: 1524 ----ELSRLRQDLQDRTTQEEQLRQQITEKEEKTRK 1555



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 54/238 (22%), Positives = 104/238 (43%), Gaps = 38/238 (15%)

Query: 587 KASSESSYLSI---LPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMD 643
           K  SE  Y  I   L  + E +  E R  +   +E  ++   N L+ L +K K++    D
Sbjct: 47  KVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLN--NQLKALTEKNKELEIAQD 104

Query: 644 ESFRELDMECALLDGEQKSETTELMKEKEIL----DHLNRKIAELEKNIVGEKTKDADL- 698
            +   +  +      E ++E  +L++  E L    ++L   +  L + +    T   +L 
Sbjct: 105 RNIA-IQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQ 163

Query: 699 LDVESKHFEDLEFQQLEHESRLDEEKENL--------------TQQLL-------REVAE 737
           L ++     D+  +    E RL++EKE L              T +LL        E+ E
Sbjct: 164 LKLDELQASDVSVKY--REKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE 221

Query: 738 YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
            + N+ ++KE++S L++Q N +    +   +H  K   +L+  L+  KE   ++E+K+
Sbjct: 222 LKCNLENKKEEVSRLEEQMNGL----KTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF 275



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 67/380 (17%), Positives = 166/380 (43%), Gaps = 22/380 (5%)

Query: 424  SLRQASGTPQPA-LRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRL-ETIL 481
            S  Q   TP P  + E   +I + +    L +     ++E+   ++++  + ++L E + 
Sbjct: 646  STSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVT 705

Query: 482  SLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 541
             L ++ TK  ++L   +   ++ + N E  + +++   S+ E       T  +  +  + 
Sbjct: 706  DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREIT---SLHERNQKLTATTQKQEQIINT 762

Query: 542  PDADLASCGSLSQSSASFFTPRSTRNDELLSDLT--RTPPPPSSTFPKASSESSYLSILP 599
               DL   G+  + + +     + + ++ +  L+  R      S   +   ++  L+ L 
Sbjct: 763  MTQDLR--GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL- 819

Query: 600  KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
            +T +GI E   ++    +      + + +  LK+K+++  +Q     R LD++      +
Sbjct: 820  QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQ 879

Query: 660  QKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVES--------KHFEDLEF 711
              +ET   +  KE+L +  ++IA L++++   + + A      +        +  +DL  
Sbjct: 880  LDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVS 939

Query: 712  QQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI---VQQAQREQD 768
            Q  + E ++++ KE L +     V +YQ  + S +E ++  K+    +   ++   +E  
Sbjct: 940  QLRQTEEQVNDLKERL-KTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESA 998

Query: 769  HFVKEKNNLIMMLQREKENL 788
             F  +    +M +++EK+ L
Sbjct: 999  EFQTQLEKKLMEVEKEKQEL 1018



 Score = 38.5 bits (88), Expect = 0.040
 Identities = 92/448 (20%), Positives = 174/448 (38%), Gaps = 54/448 (12%)

Query: 663  ETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDE 722
            E+TE ++ K  L  L       +K     +    + L+   +   DL  Q  +  ++LD 
Sbjct: 661  ESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDF 720

Query: 723  EKENLTQQLLREVAEYQRNIVS---RKEKISALKKQANHIVQQAQREQDHFVKEKNNLIM 779
              +   + L   V  Y+R I S   R +K++A  ++   I+    ++    ++  N  + 
Sbjct: 721  ASKRY-EMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQD----LRGANEKLA 775

Query: 780  MLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPA 839
            + +   ENL   EK+   LS      V  +  +E  ++     E  G +  L+       
Sbjct: 776  VAEVRAENL-KKEKEMLKLS-----EVRLSQQRESLLA-----EQRGQNLLLTNLQTIQG 824

Query: 840  DADAVATEPATAVLASQPQSKEHFRSLEERKKQHKE----------GLYLSDTLPRKKTT 889
              +   TE     L+SQ +  EH  S  ++K +++            + L DT  +  T 
Sbjct: 825  ILERSETETKQR-LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTE 883

Query: 890  SSISPHFSSATMGRSI-----TPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 944
            +++  H ++  + ++      T K HL    SN    V   S     K   S +      
Sbjct: 884  TNL--HLNTKELLKNAQKEIATLKQHL----SNMEVQVASQSSQRTGKGQPSNKEDVDDL 937

Query: 945  HQQMSEGHRQKSEFYNRT-ASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISAC 1003
              Q+ +   Q ++   R   S SNV            + QA  T SL+ S + E  ++  
Sbjct: 938  VSQLRQTEEQVNDLKERLKTSTSNVE-----------QYQAMVT-SLEESLNKEKQVTEE 985

Query: 1004 SPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK 1063
               NI      +     ++E+ L +   EK  L + + R +E+ ++ L E K+    ++ 
Sbjct: 986  VRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQN 1045

Query: 1064 RLQEETSQRQKLIEKEVKIRERQRAQAR 1091
             +QE   +    +  E + R   + QA+
Sbjct: 1046 EVQEALQRASTALSNEQQARRDCQEQAK 1073



 Score = 37.7 bits (86), Expect = 0.068
 Identities = 85/404 (21%), Positives = 157/404 (38%), Gaps = 78/404 (19%)

Query: 435 ALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRL 494
           AL E+   +     R+  +     + +E L   E E+ +  R    LS   EY       
Sbjct: 91  ALTEKNKELEIAQDRNIAIQSQFTRTKEEL---EAEKRDLIRTNERLSQELEYL------ 141

Query: 495 STGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYRCHRKDSLPDADLASCGSLS 553
                 EDV+++N++L++   +  E   + + L + D   +   K    + +L     L 
Sbjct: 142 -----TEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKEL-----LH 191

Query: 554 QSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQE 613
             +    T   T+ DELL+ L R          K +        L    E +S  +  ++
Sbjct: 192 SQNTWLNTELKTKTDELLA-LGRE---------KGNEILELKCNLENKKEEVSRLE--EQ 239

Query: 614 LAAMEETRIVILNNLEELKQKIKDINDQ---MDESFR-ELDMECALLDGEQKSETTELMK 669
           +  ++ +   +  ++E+L  K+K+  +Q   M+E F  EL+    L +  + +      K
Sbjct: 240 MNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAK 299

Query: 670 EKEILDHLNRKIAELEKNI--VGEKTKDAD--LLDVESKHFEDLEFQQLEHESRLDEEKE 725
             E    L R + EL K +   GE  K     LL+VE    + +E + LE   RL++E E
Sbjct: 300 SNE----LTRAVEELHKLLKEAGEANKAIQDHLLEVEQSK-DQMEKEMLEKIGRLEKELE 354

Query: 726 NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ------------------------ 761
           N    L    A  ++  +  +E+++A+   A  + +                        
Sbjct: 355 NANDLLS---ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411

Query: 762 ------QAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS 799
                 +  +  D  VKE      +L+R++E     +K  +SLS
Sbjct: 412 EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLS 455



 Score = 31.2 bits (69), Expect = 6.4
 Identities = 27/107 (25%), Positives = 48/107 (44%), Gaps = 7/107 (6%)

Query: 994  DSMETSISACSPDN--ISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRAL 1051
            + +   + A +  N  +  A   NIA   +  R  ++  AEK  L+ + ER  +  +   
Sbjct: 83   EKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLT 142

Query: 1052 EEEKRRREILEKRLQEETSQRQKLIEKE-----VKIRERQRAQARPL 1093
            E+ KR  E L++    +   + KL E +     VK RE++  Q + L
Sbjct: 143  EDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKEL 189


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 79/392 (20%), Positives = 170/392 (43%), Gaps = 43/392 (10%)

Query: 413  GSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQE--ME 470
            G ++  +  +  L       +  L++++  +S +  + D    H  Q +++++E +  +E
Sbjct: 1061 GDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIE 1120

Query: 471  RLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 530
             LE + +E   +L A+  K  S L+      ++++I++ LE  + S   S   E     +
Sbjct: 1121 ELEEE-IEAEHTLRAKIEKQRSDLA-----RELEEISERLE--EASGATSAQIEMNKKRE 1172

Query: 531  TRYRCHRKDSLPDADL---ASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPK 587
              ++  R+D L +A L   A+  +L +  A        + D L     +     S    +
Sbjct: 1173 AEFQKMRRD-LEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME 1231

Query: 588  ASSESSYLSILPKTPEGISE-----EQRSQELAAMEETRIVILNNLEELKQKIKDINDQM 642
                +S +  L K+   I       E +  E+ A +E +  ++++L   K +++  N ++
Sbjct: 1232 IDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGEL 1291

Query: 643  DESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGE-KTKDADLLDV 701
                 E           ++S  ++L K K+ L    +++ EL++ +  E K K+A    +
Sbjct: 1292 SHRVEE-----------KESLISQLTKSKQAL---TQQLEELKRQMEEETKAKNAMAHAL 1337

Query: 702  ES-KHFEDLEFQQLEHESRLDEEKENLTQQLLREVAE----YQRNIVSRKEKISALKKQA 756
            +S +H  DL  +Q E E     E +    +   EVA+    Y+ + + R E++   KK+ 
Sbjct: 1338 QSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1397

Query: 757  NHIVQQAQREQDHFVKEKNNLIMMLQREKENL 788
               +Q+A+       +  N+    L++ K+ L
Sbjct: 1398 AQRLQEAEEN----TETANSKCASLEKTKQRL 1425



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 76/372 (20%), Positives = 151/372 (40%), Gaps = 35/372 (9%)

Query: 415  VEFDE--ADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERL 472
            +E D+  +++E+L ++    +   R  +   S I  +D+       Q+ + + +  M++ 
Sbjct: 1230 MEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDE-------QQTQLIHDLNMQKA 1282

Query: 473  ERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTR 532
              Q     LS   E  + +S +S  T  +  Q + ++LE+L+   EE    +  M+   +
Sbjct: 1283 RLQTQNGELSHRVE--EKESLISQLT--KSKQALTQQLEELKRQMEEETKAKNAMAHALQ 1338

Query: 533  YRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSES 592
               H  D L +          ++ A      S  N E+    T+          +     
Sbjct: 1339 SSRHDCDLLRE----QYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1394

Query: 593  SYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDME 652
              L+            QR QE     ET      +LE+ KQ+++   + +          
Sbjct: 1395 KKLA------------QRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA 1442

Query: 653  CALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQ 712
            CA LD +Q++    L + K+ LD    ++   +K      T+   + +   +  + LE  
Sbjct: 1443 CATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETL 1502

Query: 713  QLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVK 772
            + E+++ L EE  +LT+Q    +AE  +N+    EK   L +Q    +Q A  E +  ++
Sbjct: 1503 RRENKN-LQEEISDLTEQ----IAETGKNL-QEAEKTKKLVEQEKSDLQVALEEVEGSLE 1556

Query: 773  EKNNLIMMLQRE 784
             + + I+ +Q E
Sbjct: 1557 HEESKILRVQLE 1568



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 41/209 (19%), Positives = 88/209 (42%), Gaps = 16/209 (7%)

Query: 606  SEEQRSQELAAMEETRIVILNNLEELKQKIKDIND---QMDESFRELDMECALLDGEQKS 662
            S EQ  +  A +E  +  +  +L+  ++ I D+ +   Q++E  ++ + E + L  +   
Sbjct: 1041 SLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDD 1100

Query: 663  ETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLE------------ 710
            E    ++ ++ +  L  +I ELE+ I  E T  A +    S    +LE            
Sbjct: 1101 EQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGA 1160

Query: 711  -FQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDH 769
               Q+E   + + E + + + L     +++    + ++K +    +    +   QR +  
Sbjct: 1161 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK 1220

Query: 770  FVKEKNNLIMMLQREKENLCNLEKKYSSL 798
              KEK+ L M +     N+  L K  S++
Sbjct: 1221 LEKEKSELKMEIDDMASNIEALSKSKSNI 1249



 Score = 38.9 bits (89), Expect = 0.031
 Identities = 78/387 (20%), Positives = 166/387 (42%), Gaps = 53/387 (13%)

Query: 439  RKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS-TG 497
            RK    S++   + +D  +R +++  +E+   ++E   ++ + S     +K  S +  T 
Sbjct: 1197 RKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME---IDDMASNIEALSKSKSNIERTC 1253

Query: 498  TTVED---------------VQKINKELEKLQLSDEESVF----EEALMSPDTRYRCHRK 538
             TVED               +  +N +  +LQ  + E       +E+L+S  T+ +    
Sbjct: 1254 RTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALT 1313

Query: 539  DSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSIL 598
              L +            +A     +S+R+D    DL R          +  +++     L
Sbjct: 1314 QQLEELKRQMEEETKAKNAMAHALQSSRHD---CDLLR-----EQYEEEQEAKAELQRAL 1365

Query: 599  PKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDG 658
             K    +++ +   E  A++ T       LEE K+K+     + +E+    + +CA L+ 
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTE-----ELEEAKKKLAQRLQEAEENTETANSKCASLEK 1420

Query: 659  EQ---KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFE---DLEFQ 712
             +   + E  +LM++   L+  +   A L+K    ++  D  L + + K  E   +LE  
Sbjct: 1421 TKQRLQGEVEDLMRD---LERSHTACATLDKK---QRNFDKVLAEWKQKLDESQAELEAA 1474

Query: 713  QLEHESRLDE--EKENLTQQLLREVAEYQRNIVSRKEKISALKKQ---ANHIVQQAQREQ 767
            Q E  S   E  +  N  ++++ ++   +R   + +E+IS L +Q       +Q+A++ +
Sbjct: 1475 QKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTK 1534

Query: 768  DHFVKEKNNLIMMLQREKENLCNLEKK 794
                +EK++L + L+  + +L + E K
Sbjct: 1535 KLVEQEKSDLQVALEEVEGSLEHEESK 1561



 Score = 38.1 bits (87), Expect = 0.052
 Identities = 72/360 (20%), Positives = 151/360 (41%), Gaps = 43/360 (11%)

Query: 415  VEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEME--RL 472
            +E DE ++E L++ S     AL+    +   I  R+D +   +++ E  L E E++    
Sbjct: 1581 IEKDE-EIEQLKRNSQRAAEALQSVLDA--EIRSRNDALRL-KKKMEGDLNEMEIQLGHS 1636

Query: 473  ERQRLETILSL-CAEYTKPDSRLSTGTTVEDVQKINKEL-EKLQLSDEES--VFEEALMS 528
             RQ  ET   L   +    DS+L     ++D  + N++L E+L + +  +  + EE    
Sbjct: 1637 NRQMAETQKHLRTVQGQLKDSQLH----LDDALRSNEDLKEQLAIVERRNGLLLEELEEM 1692

Query: 529  PDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKA 588
                 +  R   L + +L       Q   S  T       +L +D+ +      ++  ++
Sbjct: 1693 KVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQES 1752

Query: 589  SSESSYLSILPKTPEGISEE-QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFR 647
             +         K  + I++    ++EL   ++T   +    + L+Q +KD+  ++DE   
Sbjct: 1753 RNAEE------KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE--- 1803

Query: 648  ELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFE 707
                          +E   L   K+ +  L  ++ ELE  +  E+ + A+ L  +  H  
Sbjct: 1804 --------------AEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEAL--KGAHKY 1847

Query: 708  DLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQ 767
            + + +++ +++  D +     Q L   V + Q  + S K +    ++QAN  + + +R Q
Sbjct: 1848 ERKVKEMTYQAEEDHKNILRLQDL---VDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQ 1904



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 37/145 (25%), Positives = 60/145 (41%), Gaps = 37/145 (25%)

Query: 1017 ARIEEMERLLKQAHAEKTRLLESRE---REMEA-------------------KKRALEEE 1054
            ARIEE+E  ++  H  + ++ + R    RE+E                    KKR  E +
Sbjct: 1117 ARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQ 1176

Query: 1055 KRRREILEKRLQEETS-------QRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR 1107
            K RR++ E  LQ E +       Q   + E   +I   QR + +       + KE  +L+
Sbjct: 1177 KMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK-------LEKEKSELK 1229

Query: 1108 SHVETAGHNIDT-CYHVSITEKTCR 1131
              ++    NI+      S  E+TCR
Sbjct: 1230 MEIDDMASNIEALSKSKSNIERTCR 1254


>gi|118498356 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 145/741 (19%), Positives = 292/741 (39%), Gaps = 88/741 (11%)

Query: 425  LRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLC 484
            +R+ +   + A ++ +S    ++  +++   H +  +  + +Q++E+   Q +E+     
Sbjct: 504  IRKRTAEHEAAQQDLQSKF--VAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES----- 556

Query: 485  AEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDA 544
             E  + +   S    V+D+ + N+ L K Q+    S       +       H+  +  D 
Sbjct: 557  -EQKRVNKEESLQMQVQDILEQNEAL-KAQIQQFHSQIAAQTSASVLAEELHKVIAEKDK 614

Query: 545  DLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPK----ASSESSYLSILPK 600
             +      ++ S +    R T  +E L D+        +   K    A+ +++    L K
Sbjct: 615  QIKQ----TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEK 670

Query: 601  TPEGIS---------EEQRSQELA-AMEETRIVILNN--LEELKQKI---------KDIN 639
              + +          EEQ   E++  MEE +I+   N  L+   QK+         KD+ 
Sbjct: 671  MQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV 730

Query: 640  DQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL 699
            +QM++  +E D +   ++   ++   ++  ++E L+ +  + + L K +   K K  D +
Sbjct: 731  EQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQV 790

Query: 700  DVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI 759
               S   E+L+    E + ++   +E L  +LL+ VA  ++ +   K++I ALK++  ++
Sbjct: 791  SFASL-VEELKKVIHEKDGKIKSVEELLEAELLK-VANKEKTVQDLKQEIKALKEEIGNV 848

Query: 760  VQQAQREQDHFVKEKNNLIMMLQREKENLCN-----LEKKYSSLSG-GKGFPVNPNTLKE 813
              Q ++ Q   +  K   +  L + KE   N     LE+K   L+  GK         + 
Sbjct: 849  --QLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENES 906

Query: 814  GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKK-- 871
                V E+ +   N    S ++QF  + + V  E    +   +   KE    L  + +  
Sbjct: 907  LKAHVQEVAQ--HNLKEASSASQF-EELEIVLKEKENELKRLEAMLKERESDLSSKTQLL 963

Query: 872  ---QHKEGLYLSDTLPRK----KTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLP 924
               Q +  L+ S     K    +  SS  PH     + + I+ +     G  N   S L 
Sbjct: 964  QDVQDENKLFKSQIEQLKQQNYQQASSFPPH---EELLKVISEREKEISGLWNELDS-LK 1019

Query: 925  PSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQA 984
             ++    K +   R       + ++   +   +  N+T+ E    + +          + 
Sbjct: 1020 DAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKL 1079

Query: 985  FDTLSLDSSDS-------METSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLL 1037
            F  +S+ S+ S        E     C       A TS    ++ +E  LK+A    T L 
Sbjct: 1080 FPKVSVPSNLSYGEWLHGFEKKAKEC------MAGTSGSEEVKVLEHKLKEADEMHTLL- 1132

Query: 1038 ESREREMEAKKRALEEEKRRREILEKRL-QEETSQRQKLIEKEVKIRERQRAQARPLTRY 1096
               + E E  K  L E +   + L++ + QEE   + K+ E    I++ Q +        
Sbjct: 1133 ---QLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQEL 1189

Query: 1097 LPVRKEDFDL------RSHVE 1111
              +R E+ D+      R H+E
Sbjct: 1190 ERLRSENKDIENLRREREHLE 1210



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 67/328 (20%), Positives = 126/328 (38%), Gaps = 29/328 (8%)

Query: 436  LRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS 495
            LRE+           + M   +  +  + R+Q++E +E +  E +  L  + + P S LS
Sbjct: 1032 LREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVP-SNLS 1090

Query: 496  TGTTVEDVQKINKE-LEKLQLSDEESVFEEALMSPDTRY-----RCHRKDSLPDADLASC 549
             G  +   +K  KE +     S+E  V E  L   D  +      C +  S+    LA  
Sbjct: 1091 YGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSV----LAET 1146

Query: 550  GSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQ 609
              + Q           +    + +  +T     S+F  +  E   L    K  E +  E+
Sbjct: 1147 EGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRER 1206

Query: 610  R--SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL---DMECALLDGEQKSET 664
                 EL   E  R   +  + ELK  + ++  ++D+S+ E    + E  LL  +     
Sbjct: 1207 EHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETL 1266

Query: 665  TELMKEKEILD------HLNRKIAELEKNIVGEKTKDADLL-------DVESKHFEDLEF 711
            T+L  E+          H  ++  EL ++ + +   D  ++       + ES   E +  
Sbjct: 1267 TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSV 1326

Query: 712  QQLEHESRLDEEKENLTQQLLREVAEYQ 739
               +  ++L +  + + QQL +E   YQ
Sbjct: 1327 SLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1354


>gi|33620775 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 145/741 (19%), Positives = 292/741 (39%), Gaps = 88/741 (11%)

Query: 425  LRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLC 484
            +R+ +   + A ++ +S    ++  +++   H +  +  + +Q++E+   Q +E+     
Sbjct: 504  IRKRTAEHEAAQQDLQSKF--VAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES----- 556

Query: 485  AEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDA 544
             E  + +   S    V+D+ + N+ L K Q+    S       +       H+  +  D 
Sbjct: 557  -EQKRVNKEESLQMQVQDILEQNEAL-KAQIQQFHSQIAAQTSASVLAEELHKVIAEKDK 614

Query: 545  DLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPK----ASSESSYLSILPK 600
             +      ++ S +    R T  +E L D+        +   K    A+ +++    L K
Sbjct: 615  QIKQ----TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEK 670

Query: 601  TPEGIS---------EEQRSQELA-AMEETRIVILNN--LEELKQKI---------KDIN 639
              + +          EEQ   E++  MEE +I+   N  L+   QK+         KD+ 
Sbjct: 671  MQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV 730

Query: 640  DQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL 699
            +QM++  +E D +   ++   ++   ++  ++E L+ +  + + L K +   K K  D +
Sbjct: 731  EQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQV 790

Query: 700  DVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI 759
               S   E+L+    E + ++   +E L  +LL+ VA  ++ +   K++I ALK++  ++
Sbjct: 791  SFASL-VEELKKVIHEKDGKIKSVEELLEAELLK-VANKEKTVQDLKQEIKALKEEIGNV 848

Query: 760  VQQAQREQDHFVKEKNNLIMMLQREKENLCN-----LEKKYSSLSG-GKGFPVNPNTLKE 813
              Q ++ Q   +  K   +  L + KE   N     LE+K   L+  GK         + 
Sbjct: 849  --QLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENES 906

Query: 814  GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKK-- 871
                V E+ +   N    S ++QF  + + V  E    +   +   KE    L  + +  
Sbjct: 907  LKAHVQEVAQ--HNLKEASSASQF-EELEIVLKEKENELKRLEAMLKERESDLSSKTQLL 963

Query: 872  ---QHKEGLYLSDTLPRK----KTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLP 924
               Q +  L+ S     K    +  SS  PH     + + I+ +     G  N   S L 
Sbjct: 964  QDVQDENKLFKSQIEQLKQQNYQQASSFPPH---EELLKVISEREKEISGLWNELDS-LK 1019

Query: 925  PSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQA 984
             ++    K +   R       + ++   +   +  N+T+ E    + +          + 
Sbjct: 1020 DAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKL 1079

Query: 985  FDTLSLDSSDS-------METSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLL 1037
            F  +S+ S+ S        E     C       A TS    ++ +E  LK+A    T L 
Sbjct: 1080 FPKVSVPSNLSYGEWLHGFEKKAKEC------MAGTSGSEEVKVLEHKLKEADEMHTLL- 1132

Query: 1038 ESREREMEAKKRALEEEKRRREILEKRL-QEETSQRQKLIEKEVKIRERQRAQARPLTRY 1096
               + E E  K  L E +   + L++ + QEE   + K+ E    I++ Q +        
Sbjct: 1133 ---QLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQEL 1189

Query: 1097 LPVRKEDFDL------RSHVE 1111
              +R E+ D+      R H+E
Sbjct: 1190 ERLRSENKDIENLRREREHLE 1210



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 67/328 (20%), Positives = 126/328 (38%), Gaps = 29/328 (8%)

Query: 436  LRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS 495
            LRE+           + M   +  +  + R+Q++E +E +  E +  L  + + P S LS
Sbjct: 1032 LREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVP-SNLS 1090

Query: 496  TGTTVEDVQKINKE-LEKLQLSDEESVFEEALMSPDTRY-----RCHRKDSLPDADLASC 549
             G  +   +K  KE +     S+E  V E  L   D  +      C +  S+    LA  
Sbjct: 1091 YGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSV----LAET 1146

Query: 550  GSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQ 609
              + Q           +    + +  +T     S+F  +  E   L    K  E +  E+
Sbjct: 1147 EGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRER 1206

Query: 610  R--SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL---DMECALLDGEQKSET 664
                 EL   E  R   +  + ELK  + ++  ++D+S+ E    + E  LL  +     
Sbjct: 1207 EHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETL 1266

Query: 665  TELMKEKEILD------HLNRKIAELEKNIVGEKTKDADLL-------DVESKHFEDLEF 711
            T+L  E+          H  ++  EL ++ + +   D  ++       + ES   E +  
Sbjct: 1267 TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSV 1326

Query: 712  QQLEHESRLDEEKENLTQQLLREVAEYQ 739
               +  ++L +  + + QQL +E   YQ
Sbjct: 1327 SLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1354


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)

Query: 416  EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 474
            E  E +LE  RQ A GT Q  L   +  I   +      +  + +++ +L E+E+ RL+R
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1741

Query: 475  Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 527
            +       R E    L     + +  L++    E+  +   E  K +L  E   F E L 
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1800

Query: 528  SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 585
                R R   +++     LA   +  Q + +         ++L  + + TR         
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1856

Query: 586  PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 645
             +  +E+  L  L +  +   + +R +E AA  +       ++EE   +++  +D   E 
Sbjct: 1857 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1908

Query: 646  FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 704
             + L +E  L    Q  E  E++  K   +      AELE  +   ++   D L   E  
Sbjct: 1909 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1965

Query: 705  HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 760
              E    +QL  E E R  E +E + + L    E A  ++  +   E++ A  ++A  + 
Sbjct: 1966 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2025

Query: 761  QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
            ++A++E    ++             EK +   + Q+E+E    L+++ S L   +G    
Sbjct: 2026 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2085

Query: 808  PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 865
                 E      V    E   +   +  + +    A+  A   A A  A++   KE  + 
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2145

Query: 866  LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 922
               R +  +  L     +D    K    +       A + + +T    L L +++   ++
Sbjct: 2146 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2204

Query: 923  LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 979
            L   L  +  ++      R    +++     Q  E      R  +E+   +         
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264

Query: 980  YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1035
            +  +  + +   + ++   S++A     +   +  ++A+   + E++LK   QA  E TR
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324

Query: 1036 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1079
            L    E   + K+ A E+ +R +E  E+   +L EET   Q+ +E E             
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384

Query: 1080 --VKIRERQRAQAR 1091
              +++ E  RAQAR
Sbjct: 2385 LKLRVAEMSRAQAR 2398



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)

Query: 600  KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
            K  E I E+    ELA  E  ++ ++  LE  +Q+     +++ E+  EL+ E   L  E
Sbjct: 2408 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465

Query: 660  QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 704
             K     SE  + ++++++L          L+ K  + + E+ I  EK K   L   E  
Sbjct: 2466 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525

Query: 705  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
              + L  +Q   + ++++E+    Q+L+  + E +R     +E +   +++   + QQ +
Sbjct: 2526 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2580

Query: 765  REQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
            R+Q+  + E+N      QR +E L  LE+++
Sbjct: 2581 RQQEELLAEEN------QRLREQLQLLEEQH 2605



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)

Query: 227  SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 286
            +MP +  QA +  ++   AL  ++ RH E   E      ++++   ++ +  Y   L   
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1288

Query: 287  YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 341
            Y+A   QL P++ P +       + + G + +    +D   +Y   ++L+S  + +    
Sbjct: 1289 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340

Query: 342  -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 394
                   +  A +        L+   +    ++ L  + +   +    +A  +       
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400

Query: 395  LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 438
            ++  E   V A ++  S         +  EA++++  RQA    +  LR          +
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460

Query: 439  RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 492
             +++     G +  +   R + EE     R  ++E ERL RQ + E+     AE      
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520

Query: 493  RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
              +      + Q+  + LE+L+L  EE+  E  L   +       + +L  A  ++   L
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1578

Query: 553  SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
                ASF         E  + L R            S +  ++++     E    E+R+Q
Sbjct: 1579 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1615

Query: 613  ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
            + A  E  R       EE +++++    + +E+ R L ++   +  ++     E  K+KE
Sbjct: 1616 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1667

Query: 673  ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
              +   R+  + E+  V ++      L+ + +  E         + RL  E+E +  +  
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1721

Query: 733  REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 788
             E  E QR ++  +E+++ L+++A    Q+ Q  +    K +  + ++L    + E+E+ 
Sbjct: 1722 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779

Query: 789  CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 846
               EK    L    G       L E    +  + E       L+   + +  A+A+ V  
Sbjct: 1780 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836

Query: 847  EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 877
            E   A+           +A + +  E+              R LEE+  QHK  +     
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896

Query: 878  ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 918
                            + DTL +++       ++   F  A  G++   +  L LG+  S
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1953

Query: 919  CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 969
                       + L  +        E RR        Q S    +++    + A E    
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013

Query: 970  LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1029
            L +        +++A      +S+  ++ +  A +   + +   ++   +++ E+ L+Q 
Sbjct: 2014 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2068

Query: 1030 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1083
              ++  +L+    E EA +RA EE +       RE  + R Q E ++R K   E++ + R
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128

Query: 1084 ERQRAQARPLTR 1095
             + +A A  L +
Sbjct: 2129 AQAQAAAEKLRK 2140



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)

Query: 401  DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 460
            + + A + +F   +    E +LE  R  S        + ++ + +   R    +  RR+R
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1984

Query: 461  EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 520
            E   R Q+             SL AE      R +    +E+V+++  ++E+ +   E +
Sbjct: 1985 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2028

Query: 521  VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 580
              E A      +    ++  L   + A   ++ Q        ++ + ++ + D  R    
Sbjct: 2029 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2081

Query: 581  PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 638
             +    +A+ E+    +  +     S  Q   ++ L    E +       +   +K++  
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141

Query: 639  NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 698
             +Q  E+ R    E A L  +Q ++  E+ K K+  +   R+ A++E+ +   +      
Sbjct: 2142 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2192

Query: 699  LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 758
                      L+ ++ +H+  L +E+    Q+L  E  E  R     +E++ +++ Q   
Sbjct: 2193 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239

Query: 759  IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 814
            + + +A+ E ++    +++K+N    LQ E E +  + ++ + LS           L E 
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299

Query: 815  YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 863
             ++         + E  +    +T L    +       +A E A  +   + Q  +    
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359

Query: 864  ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 917
                  R+LE  +++  E    ++ L  K   + +S   + A        K    +G+  
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417

Query: 918  SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 971
                +       + +  E +R    ++ +++ E   +      +   E+ +       + 
Sbjct: 2418 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2477

Query: 972  SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 1021
            +        + QA     L   DS+          +  +     D ++ A        EE
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2533

Query: 1022 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1081
             +R  +Q   E+ RL+ S E     +  A E  +R++E L++  Q+   Q + L E+  +
Sbjct: 2534 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593

Query: 1082 IRER 1085
            +RE+
Sbjct: 2594 LREQ 2597



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)

Query: 419  EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 474
            EA+L+S R AS   + A  ER      ++      +  RR ++    ER RE+    LER
Sbjct: 1575 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633

Query: 475  QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 530
             +L+      L L AE       L+     +  ++  +E  +   ++E++V +  L   +
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693

Query: 531  TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 589
               +    +      LA+   L +  A   T +  +  +LL + L R     ++   K  
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1751

Query: 590  SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 649
               + L+ +    E +   +   E    EE+R    +  E+ KQ+++    +    FREL
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1799

Query: 650  DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 708
              E A L    ++   E  +++++ +    R+ AE E+ +  +     +   ++++    
Sbjct: 1800 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855

Query: 709  LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 766
            L+ ++ E+E   RL E++    ++L  + A+++ +I   +E+++ L+K ++  +++ +  
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1912

Query: 767  QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 826
             +  ++++  +       +E +  L+  +   + GK          E  + +  I     
Sbjct: 1913 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1956

Query: 827  NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 885
            ++       +  A     +A E       ++ + ++   + EE  +Q K  L   + L  
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016

Query: 886  KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 945
            K   +      +     R +  +      Q          + A   K+ E ++ L+    
Sbjct: 2017 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2072

Query: 946  QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 1005
            Q + +  R ++E   R A E+            + ++ A     ++ ++ ++ S    + 
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126

Query: 1006 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1055
                + + +        E+L K+A  E  R  ++           + EME  K+  E+  
Sbjct: 2127 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178

Query: 1056 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1108
            R++  +E+ L       EET  ++ L+++E+   +R +A+A    R    V +E F +R 
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2235

Query: 1109 HVE 1111
             +E
Sbjct: 2236 QME 2238



 Score = 34.3 bits (77), Expect = 0.76
 Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)

Query: 1020 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1066
            +E+E  L +  AE   LL S+ R  E  +   E+ K+R        RE+ E     + L 
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810

Query: 1067 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1113
            EE  ++++L E++     RQRA+A R L   L    E   L++  E A
Sbjct: 1811 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)

Query: 416  EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 474
            E  E +LE  RQ A GT Q  L   +  I   +      +  + +++ +L E+E+ RL+R
Sbjct: 1692 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1745

Query: 475  Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 527
            +       R E    L     + +  L++    E+  +   E  K +L  E   F E L 
Sbjct: 1746 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1804

Query: 528  SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 585
                R R   +++     LA   +  Q + +         ++L  + + TR         
Sbjct: 1805 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1860

Query: 586  PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 645
             +  +E+  L  L +  +   + +R +E AA  +       ++EE   +++  +D   E 
Sbjct: 1861 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1912

Query: 646  FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 704
             + L +E  L    Q  E  E++  K   +      AELE  +   ++   D L   E  
Sbjct: 1913 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1969

Query: 705  HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 760
              E    +QL  E E R  E +E + + L    E A  ++  +   E++ A  ++A  + 
Sbjct: 1970 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2029

Query: 761  QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
            ++A++E    ++             EK +   + Q+E+E    L+++ S L   +G    
Sbjct: 2030 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2089

Query: 808  PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 865
                 E      V    E   +   +  + +    A+  A   A A  A++   KE  + 
Sbjct: 2090 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2149

Query: 866  LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 922
               R +  +  L     +D    K    +       A + + +T    L L +++   ++
Sbjct: 2150 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2208

Query: 923  LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 979
            L   L  +  ++      R    +++     Q  E      R  +E+   +         
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268

Query: 980  YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1035
            +  +  + +   + ++   S++A     +   +  ++A+   + E++LK   QA  E TR
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328

Query: 1036 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1079
            L    E   + K+ A E+ +R +E  E+   +L EET   Q+ +E E             
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388

Query: 1080 --VKIRERQRAQAR 1091
              +++ E  RAQAR
Sbjct: 2389 LKLRVAEMSRAQAR 2402



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)

Query: 600  KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
            K  E I E+    ELA  E  ++ ++  LE  +Q+     +++ E+  EL+ E   L  E
Sbjct: 2412 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2469

Query: 660  QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 704
             K     SE  + ++++++L          L+ K  + + E+ I  EK K   L   E  
Sbjct: 2470 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2529

Query: 705  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
              + L  +Q   + ++++E+    Q+L+  + E +R     +E +   +++   + QQ +
Sbjct: 2530 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2584

Query: 765  REQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
            R+Q+  + E+N      QR +E L  LE+++
Sbjct: 2585 RQQEELLAEEN------QRLREQLQLLEEQH 2609



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)

Query: 227  SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 286
            +MP +  QA +  ++   AL  ++ RH E   E      ++++   ++ +  Y   L   
Sbjct: 1239 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1292

Query: 287  YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 341
            Y+A   QL P++ P +       + + G + +    +D   +Y   ++L+S  + +    
Sbjct: 1293 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1344

Query: 342  -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 394
                   +  A +        L+   +    ++ L  + +   +    +A  +       
Sbjct: 1345 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1404

Query: 395  LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 438
            ++  E   V A ++  S         +  EA++++  RQA    +  LR          +
Sbjct: 1405 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1464

Query: 439  RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 492
             +++     G +  +   R + EE     R  ++E ERL RQ + E+     AE      
Sbjct: 1465 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1524

Query: 493  RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
              +      + Q+  + LE+L+L  EE+  E  L   +       + +L  A  ++   L
Sbjct: 1525 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1582

Query: 553  SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
                ASF         E  + L R            S +  ++++     E    E+R+Q
Sbjct: 1583 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1619

Query: 613  ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
            + A  E  R       EE +++++    + +E+ R L ++   +  ++     E  K+KE
Sbjct: 1620 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1671

Query: 673  ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
              +   R+  + E+  V ++      L+ + +  E         + RL  E+E +  +  
Sbjct: 1672 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1725

Query: 733  REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 788
             E  E QR ++  +E+++ L+++A    Q+ Q  +    K +  + ++L    + E+E+ 
Sbjct: 1726 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783

Query: 789  CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 846
               EK    L    G       L E    +  + E       L+   + +  A+A+ V  
Sbjct: 1784 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1840

Query: 847  EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 877
            E   A+           +A + +  E+              R LEE+  QHK  +     
Sbjct: 1841 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1900

Query: 878  ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 918
                            + DTL +++       ++   F  A  G++   +  L LG+  S
Sbjct: 1901 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1957

Query: 919  CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 969
                       + L  +        E RR        Q S    +++    + A E    
Sbjct: 1958 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2017

Query: 970  LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1029
            L +        +++A      +S+  ++ +  A +   + +   ++   +++ E+ L+Q 
Sbjct: 2018 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2072

Query: 1030 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1083
              ++  +L+    E EA +RA EE +       RE  + R Q E ++R K   E++ + R
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2132

Query: 1084 ERQRAQARPLTR 1095
             + +A A  L +
Sbjct: 2133 AQAQAAAEKLRK 2144



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)

Query: 401  DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 460
            + + A + +F   +    E +LE  R  S        + ++ + +   R    +  RR+R
Sbjct: 1929 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1988

Query: 461  EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 520
            E   R Q+             SL AE      R +    +E+V+++  ++E+ +   E +
Sbjct: 1989 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2032

Query: 521  VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 580
              E A      +    ++  L   + A   ++ Q        ++ + ++ + D  R    
Sbjct: 2033 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2085

Query: 581  PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 638
             +    +A+ E+    +  +     S  Q   ++ L    E +       +   +K++  
Sbjct: 2086 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2145

Query: 639  NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 698
             +Q  E+ R    E A L  +Q ++  E+ K K+  +   R+ A++E+ +   +      
Sbjct: 2146 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2196

Query: 699  LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 758
                      L+ ++ +H+  L +E+    Q+L  E  E  R     +E++ +++ Q   
Sbjct: 2197 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243

Query: 759  IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 814
            + + +A+ E ++    +++K+N    LQ E E +  + ++ + LS           L E 
Sbjct: 2244 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2303

Query: 815  YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 863
             ++         + E  +    +T L    +       +A E A  +   + Q  +    
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2363

Query: 864  ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 917
                  R+LE  +++  E    ++ L  K   + +S   + A        K    +G+  
Sbjct: 2364 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421

Query: 918  SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 971
                +       + +  E +R    ++ +++ E   +      +   E+ +       + 
Sbjct: 2422 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2481

Query: 972  SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 1021
            +        + QA     L   DS+          +  +     D ++ A        EE
Sbjct: 2482 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2537

Query: 1022 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1081
             +R  +Q   E+ RL+ S E     +  A E  +R++E L++  Q+   Q + L E+  +
Sbjct: 2538 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2597

Query: 1082 IRER 1085
            +RE+
Sbjct: 2598 LREQ 2601



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)

Query: 419  EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 474
            EA+L+S R AS   + A  ER      ++      +  RR ++    ER RE+    LER
Sbjct: 1579 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637

Query: 475  QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 530
             +L+      L L AE       L+     +  ++  +E  +   ++E++V +  L   +
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1697

Query: 531  TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 589
               +    +      LA+   L +  A   T +  +  +LL + L R     ++   K  
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1755

Query: 590  SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 649
               + L+ +    E +   +   E    EE+R    +  E+ KQ+++    +    FREL
Sbjct: 1756 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1803

Query: 650  DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 708
              E A L    ++   E  +++++ +    R+ AE E+ +  +     +   ++++    
Sbjct: 1804 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1859

Query: 709  LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 766
            L+ ++ E+E   RL E++    ++L  + A+++ +I   +E+++ L+K ++  +++ +  
Sbjct: 1860 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1916

Query: 767  QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 826
             +  ++++  +       +E +  L+  +   + GK          E  + +  I     
Sbjct: 1917 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1960

Query: 827  NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 885
            ++       +  A     +A E       ++ + ++   + EE  +Q K  L   + L  
Sbjct: 1961 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2020

Query: 886  KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 945
            K   +      +     R +  +      Q          + A   K+ E ++ L+    
Sbjct: 2021 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2076

Query: 946  QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 1005
            Q + +  R ++E   R A E+            + ++ A     ++ ++ ++ S    + 
Sbjct: 2077 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2130

Query: 1006 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1055
                + + +        E+L K+A  E  R  ++           + EME  K+  E+  
Sbjct: 2131 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182

Query: 1056 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1108
            R++  +E+ L       EET  ++ L+++E+   +R +A+A    R    V +E F +R 
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2239

Query: 1109 HVE 1111
             +E
Sbjct: 2240 QME 2242



 Score = 34.3 bits (77), Expect = 0.76
 Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)

Query: 1020 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1066
            +E+E  L +  AE   LL S+ R  E  +   E+ K+R        RE+ E     + L 
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1814

Query: 1067 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1113
            EE  ++++L E++     RQRA+A R L   L    E   L++  E A
Sbjct: 1815 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1859


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)

Query: 416  EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 474
            E  E +LE  RQ A GT Q  L   +  I   +      +  + +++ +L E+E+ RL+R
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1741

Query: 475  Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 527
            +       R E    L     + +  L++    E+  +   E  K +L  E   F E L 
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1800

Query: 528  SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 585
                R R   +++     LA   +  Q + +         ++L  + + TR         
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1856

Query: 586  PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 645
             +  +E+  L  L +  +   + +R +E AA  +       ++EE   +++  +D   E 
Sbjct: 1857 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1908

Query: 646  FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 704
             + L +E  L    Q  E  E++  K   +      AELE  +   ++   D L   E  
Sbjct: 1909 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1965

Query: 705  HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 760
              E    +QL  E E R  E +E + + L    E A  ++  +   E++ A  ++A  + 
Sbjct: 1966 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2025

Query: 761  QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
            ++A++E    ++             EK +   + Q+E+E    L+++ S L   +G    
Sbjct: 2026 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2085

Query: 808  PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 865
                 E      V    E   +   +  + +    A+  A   A A  A++   KE  + 
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2145

Query: 866  LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 922
               R +  +  L     +D    K    +       A + + +T    L L +++   ++
Sbjct: 2146 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2204

Query: 923  LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 979
            L   L  +  ++      R    +++     Q  E      R  +E+   +         
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264

Query: 980  YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1035
            +  +  + +   + ++   S++A     +   +  ++A+   + E++LK   QA  E TR
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324

Query: 1036 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1079
            L    E   + K+ A E+ +R +E  E+   +L EET   Q+ +E E             
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384

Query: 1080 --VKIRERQRAQAR 1091
              +++ E  RAQAR
Sbjct: 2385 LKLRVAEMSRAQAR 2398



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)

Query: 600  KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
            K  E I E+    ELA  E  ++ ++  LE  +Q+     +++ E+  EL+ E   L  E
Sbjct: 2408 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465

Query: 660  QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 704
             K     SE  + ++++++L          L+ K  + + E+ I  EK K   L   E  
Sbjct: 2466 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525

Query: 705  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
              + L  +Q   + ++++E+    Q+L+  + E +R     +E +   +++   + QQ +
Sbjct: 2526 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2580

Query: 765  REQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
            R+Q+  + E+N      QR +E L  LE+++
Sbjct: 2581 RQQEELLAEEN------QRLREQLQLLEEQH 2605



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)

Query: 227  SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 286
            +MP +  QA +  ++   AL  ++ RH E   E      ++++   ++ +  Y   L   
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1288

Query: 287  YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 341
            Y+A   QL P++ P +       + + G + +    +D   +Y   ++L+S  + +    
Sbjct: 1289 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340

Query: 342  -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 394
                   +  A +        L+   +    ++ L  + +   +    +A  +       
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400

Query: 395  LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 438
            ++  E   V A ++  S         +  EA++++  RQA    +  LR          +
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460

Query: 439  RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 492
             +++     G +  +   R + EE     R  ++E ERL RQ + E+     AE      
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520

Query: 493  RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
              +      + Q+  + LE+L+L  EE+  E  L   +       + +L  A  ++   L
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1578

Query: 553  SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
                ASF         E  + L R            S +  ++++     E    E+R+Q
Sbjct: 1579 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1615

Query: 613  ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
            + A  E  R       EE +++++    + +E+ R L ++   +  ++     E  K+KE
Sbjct: 1616 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1667

Query: 673  ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
              +   R+  + E+  V ++      L+ + +  E         + RL  E+E +  +  
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1721

Query: 733  REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 788
             E  E QR ++  +E+++ L+++A    Q+ Q  +    K +  + ++L    + E+E+ 
Sbjct: 1722 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779

Query: 789  CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 846
               EK    L    G       L E    +  + E       L+   + +  A+A+ V  
Sbjct: 1780 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836

Query: 847  EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 877
            E   A+           +A + +  E+              R LEE+  QHK  +     
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896

Query: 878  ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 918
                            + DTL +++       ++   F  A  G++   +  L LG+  S
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1953

Query: 919  CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 969
                       + L  +        E RR        Q S    +++    + A E    
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013

Query: 970  LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1029
            L +        +++A      +S+  ++ +  A +   + +   ++   +++ E+ L+Q 
Sbjct: 2014 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2068

Query: 1030 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1083
              ++  +L+    E EA +RA EE +       RE  + R Q E ++R K   E++ + R
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128

Query: 1084 ERQRAQARPLTR 1095
             + +A A  L +
Sbjct: 2129 AQAQAAAEKLRK 2140



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)

Query: 401  DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 460
            + + A + +F   +    E +LE  R  S        + ++ + +   R    +  RR+R
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1984

Query: 461  EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 520
            E   R Q+             SL AE      R +    +E+V+++  ++E+ +   E +
Sbjct: 1985 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2028

Query: 521  VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 580
              E A      +    ++  L   + A   ++ Q        ++ + ++ + D  R    
Sbjct: 2029 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2081

Query: 581  PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 638
             +    +A+ E+    +  +     S  Q   ++ L    E +       +   +K++  
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141

Query: 639  NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 698
             +Q  E+ R    E A L  +Q ++  E+ K K+  +   R+ A++E+ +   +      
Sbjct: 2142 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2192

Query: 699  LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 758
                      L+ ++ +H+  L +E+    Q+L  E  E  R     +E++ +++ Q   
Sbjct: 2193 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239

Query: 759  IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 814
            + + +A+ E ++    +++K+N    LQ E E +  + ++ + LS           L E 
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299

Query: 815  YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 863
             ++         + E  +    +T L    +       +A E A  +   + Q  +    
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359

Query: 864  ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 917
                  R+LE  +++  E    ++ L  K   + +S   + A        K    +G+  
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417

Query: 918  SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 971
                +       + +  E +R    ++ +++ E   +      +   E+ +       + 
Sbjct: 2418 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2477

Query: 972  SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 1021
            +        + QA     L   DS+          +  +     D ++ A        EE
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2533

Query: 1022 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1081
             +R  +Q   E+ RL+ S E     +  A E  +R++E L++  Q+   Q + L E+  +
Sbjct: 2534 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593

Query: 1082 IRER 1085
            +RE+
Sbjct: 2594 LREQ 2597



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)

Query: 419  EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 474
            EA+L+S R AS   + A  ER      ++      +  RR ++    ER RE+    LER
Sbjct: 1575 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633

Query: 475  QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 530
             +L+      L L AE       L+     +  ++  +E  +   ++E++V +  L   +
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693

Query: 531  TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 589
               +    +      LA+   L +  A   T +  +  +LL + L R     ++   K  
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1751

Query: 590  SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 649
               + L+ +    E +   +   E    EE+R    +  E+ KQ+++    +    FREL
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1799

Query: 650  DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 708
              E A L    ++   E  +++++ +    R+ AE E+ +  +     +   ++++    
Sbjct: 1800 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855

Query: 709  LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 766
            L+ ++ E+E   RL E++    ++L  + A+++ +I   +E+++ L+K ++  +++ +  
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1912

Query: 767  QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 826
             +  ++++  +       +E +  L+  +   + GK          E  + +  I     
Sbjct: 1913 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1956

Query: 827  NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 885
            ++       +  A     +A E       ++ + ++   + EE  +Q K  L   + L  
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016

Query: 886  KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 945
            K   +      +     R +  +      Q          + A   K+ E ++ L+    
Sbjct: 2017 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2072

Query: 946  QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 1005
            Q + +  R ++E   R A E+            + ++ A     ++ ++ ++ S    + 
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126

Query: 1006 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1055
                + + +        E+L K+A  E  R  ++           + EME  K+  E+  
Sbjct: 2127 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178

Query: 1056 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1108
            R++  +E+ L       EET  ++ L+++E+   +R +A+A    R    V +E F +R 
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2235

Query: 1109 HVE 1111
             +E
Sbjct: 2236 QME 2238



 Score = 34.3 bits (77), Expect = 0.76
 Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)

Query: 1020 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1066
            +E+E  L +  AE   LL S+ R  E  +   E+ K+R        RE+ E     + L 
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810

Query: 1067 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1113
            EE  ++++L E++     RQRA+A R L   L    E   L++  E A
Sbjct: 1811 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)

Query: 416  EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 474
            E  E +LE  RQ A GT Q  L   +  I   +      +  + +++ +L E+E+ RL+R
Sbjct: 1656 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1709

Query: 475  Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 527
            +       R E    L     + +  L++    E+  +   E  K +L  E   F E L 
Sbjct: 1710 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1768

Query: 528  SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 585
                R R   +++     LA   +  Q + +         ++L  + + TR         
Sbjct: 1769 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1824

Query: 586  PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 645
             +  +E+  L  L +  +   + +R +E AA  +       ++EE   +++  +D   E 
Sbjct: 1825 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1876

Query: 646  FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 704
             + L +E  L    Q  E  E++  K   +      AELE  +   ++   D L   E  
Sbjct: 1877 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1933

Query: 705  HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 760
              E    +QL  E E R  E +E + + L    E A  ++  +   E++ A  ++A  + 
Sbjct: 1934 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 1993

Query: 761  QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
            ++A++E    ++             EK +   + Q+E+E    L+++ S L   +G    
Sbjct: 1994 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2053

Query: 808  PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 865
                 E      V    E   +   +  + +    A+  A   A A  A++   KE  + 
Sbjct: 2054 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2113

Query: 866  LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 922
               R +  +  L     +D    K    +       A + + +T    L L +++   ++
Sbjct: 2114 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2172

Query: 923  LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 979
            L   L  +  ++      R    +++     Q  E      R  +E+   +         
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232

Query: 980  YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1035
            +  +  + +   + ++   S++A     +   +  ++A+   + E++LK   QA  E TR
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292

Query: 1036 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1079
            L    E   + K+ A E+ +R +E  E+   +L EET   Q+ +E E             
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352

Query: 1080 --VKIRERQRAQAR 1091
              +++ E  RAQAR
Sbjct: 2353 LKLRVAEMSRAQAR 2366



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)

Query: 600  KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
            K  E I E+    ELA  E  ++ ++  LE  +Q+     +++ E+  EL+ E   L  E
Sbjct: 2376 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2433

Query: 660  QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 704
             K     SE  + ++++++L          L+ K  + + E+ I  EK K   L   E  
Sbjct: 2434 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2493

Query: 705  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
              + L  +Q   + ++++E+    Q+L+  + E +R     +E +   +++   + QQ +
Sbjct: 2494 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2548

Query: 765  REQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
            R+Q+  + E+N      QR +E L  LE+++
Sbjct: 2549 RQQEELLAEEN------QRLREQLQLLEEQH 2573



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)

Query: 227  SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 286
            +MP +  QA +  ++   AL  ++ RH E   E      ++++   ++ +  Y   L   
Sbjct: 1203 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1256

Query: 287  YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 341
            Y+A   QL P++ P +       + + G + +    +D   +Y   ++L+S  + +    
Sbjct: 1257 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1308

Query: 342  -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 394
                   +  A +        L+   +    ++ L  + +   +    +A  +       
Sbjct: 1309 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1368

Query: 395  LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 438
            ++  E   V A ++  S         +  EA++++  RQA    +  LR          +
Sbjct: 1369 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428

Query: 439  RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 492
             +++     G +  +   R + EE     R  ++E ERL RQ + E+     AE      
Sbjct: 1429 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1488

Query: 493  RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
              +      + Q+  + LE+L+L  EE+  E  L   +       + +L  A  ++   L
Sbjct: 1489 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1546

Query: 553  SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
                ASF         E  + L R            S +  ++++     E    E+R+Q
Sbjct: 1547 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1583

Query: 613  ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
            + A  E  R       EE +++++    + +E+ R L ++   +  ++     E  K+KE
Sbjct: 1584 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1635

Query: 673  ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
              +   R+  + E+  V ++      L+ + +  E         + RL  E+E +  +  
Sbjct: 1636 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1689

Query: 733  REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 788
             E  E QR ++  +E+++ L+++A    Q+ Q  +    K +  + ++L    + E+E+ 
Sbjct: 1690 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747

Query: 789  CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 846
               EK    L    G       L E    +  + E       L+   + +  A+A+ V  
Sbjct: 1748 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1804

Query: 847  EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 877
            E   A+           +A + +  E+              R LEE+  QHK  +     
Sbjct: 1805 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1864

Query: 878  ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 918
                            + DTL +++       ++   F  A  G++   +  L LG+  S
Sbjct: 1865 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1921

Query: 919  CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 969
                       + L  +        E RR        Q S    +++    + A E    
Sbjct: 1922 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1981

Query: 970  LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1029
            L +        +++A      +S+  ++ +  A +   + +   ++   +++ E+ L+Q 
Sbjct: 1982 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2036

Query: 1030 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1083
              ++  +L+    E EA +RA EE +       RE  + R Q E ++R K   E++ + R
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2096

Query: 1084 ERQRAQARPLTR 1095
             + +A A  L +
Sbjct: 2097 AQAQAAAEKLRK 2108



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)

Query: 401  DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 460
            + + A + +F   +    E +LE  R  S        + ++ + +   R    +  RR+R
Sbjct: 1893 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1952

Query: 461  EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 520
            E   R Q+             SL AE      R +    +E+V+++  ++E+ +   E +
Sbjct: 1953 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 1996

Query: 521  VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 580
              E A      +    ++  L   + A   ++ Q        ++ + ++ + D  R    
Sbjct: 1997 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2049

Query: 581  PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 638
             +    +A+ E+    +  +     S  Q   ++ L    E +       +   +K++  
Sbjct: 2050 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2109

Query: 639  NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 698
             +Q  E+ R    E A L  +Q ++  E+ K K+  +   R+ A++E+ +   +      
Sbjct: 2110 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2160

Query: 699  LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 758
                      L+ ++ +H+  L +E+    Q+L  E  E  R     +E++ +++ Q   
Sbjct: 2161 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207

Query: 759  IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 814
            + + +A+ E ++    +++K+N    LQ E E +  + ++ + LS           L E 
Sbjct: 2208 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2267

Query: 815  YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 863
             ++         + E  +    +T L    +       +A E A  +   + Q  +    
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2327

Query: 864  ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 917
                  R+LE  +++  E    ++ L  K   + +S   + A        K    +G+  
Sbjct: 2328 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2385

Query: 918  SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 971
                +       + +  E +R    ++ +++ E   +      +   E+ +       + 
Sbjct: 2386 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2445

Query: 972  SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 1021
            +        + QA     L   DS+          +  +     D ++ A        EE
Sbjct: 2446 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2501

Query: 1022 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1081
             +R  +Q   E+ RL+ S E     +  A E  +R++E L++  Q+   Q + L E+  +
Sbjct: 2502 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2561

Query: 1082 IRER 1085
            +RE+
Sbjct: 2562 LREQ 2565



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)

Query: 419  EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 474
            EA+L+S R AS   + A  ER      ++      +  RR ++    ER RE+    LER
Sbjct: 1543 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601

Query: 475  QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 530
             +L+      L L AE       L+     +  ++  +E  +   ++E++V +  L   +
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1661

Query: 531  TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 589
               +    +      LA+   L +  A   T +  +  +LL + L R     ++   K  
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1719

Query: 590  SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 649
               + L+ +    E +   +   E    EE+R    +  E+ KQ+++    +    FREL
Sbjct: 1720 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1767

Query: 650  DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 708
              E A L    ++   E  +++++ +    R+ AE E+ +  +     +   ++++    
Sbjct: 1768 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1823

Query: 709  LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 766
            L+ ++ E+E   RL E++    ++L  + A+++ +I   +E+++ L+K ++  +++ +  
Sbjct: 1824 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1880

Query: 767  QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 826
             +  ++++  +       +E +  L+  +   + GK          E  + +  I     
Sbjct: 1881 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1924

Query: 827  NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 885
            ++       +  A     +A E       ++ + ++   + EE  +Q K  L   + L  
Sbjct: 1925 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1984

Query: 886  KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 945
            K   +      +     R +  +      Q          + A   K+ E ++ L+    
Sbjct: 1985 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2040

Query: 946  QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 1005
            Q + +  R ++E   R A E+            + ++ A     ++ ++ ++ S    + 
Sbjct: 2041 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2094

Query: 1006 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1055
                + + +        E+L K+A  E  R  ++           + EME  K+  E+  
Sbjct: 2095 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146

Query: 1056 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1108
            R++  +E+ L       EET  ++ L+++E+   +R +A+A    R    V +E F +R 
Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2203

Query: 1109 HVE 1111
             +E
Sbjct: 2204 QME 2206



 Score = 34.3 bits (77), Expect = 0.76
 Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)

Query: 1020 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1066
            +E+E  L +  AE   LL S+ R  E  +   E+ K+R        RE+ E     + L 
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1778

Query: 1067 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1113
            EE  ++++L E++     RQRA+A R L   L    E   L++  E A
Sbjct: 1779 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1823


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)

Query: 416  EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 474
            E  E +LE  RQ A GT Q  L   +  I   +      +  + +++ +L E+E+ RL+R
Sbjct: 1825 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1878

Query: 475  Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 527
            +       R E    L     + +  L++    E+  +   E  K +L  E   F E L 
Sbjct: 1879 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1937

Query: 528  SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 585
                R R   +++     LA   +  Q + +         ++L  + + TR         
Sbjct: 1938 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1993

Query: 586  PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 645
             +  +E+  L  L +  +   + +R +E AA  +       ++EE   +++  +D   E 
Sbjct: 1994 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 2045

Query: 646  FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 704
             + L +E  L    Q  E  E++  K   +      AELE  +   ++   D L   E  
Sbjct: 2046 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 2102

Query: 705  HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 760
              E    +QL  E E R  E +E + + L    E A  ++  +   E++ A  ++A  + 
Sbjct: 2103 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2162

Query: 761  QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
            ++A++E    ++             EK +   + Q+E+E    L+++ S L   +G    
Sbjct: 2163 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2222

Query: 808  PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 865
                 E      V    E   +   +  + +    A+  A   A A  A++   KE  + 
Sbjct: 2223 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2282

Query: 866  LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 922
               R +  +  L     +D    K    +       A + + +T    L L +++   ++
Sbjct: 2283 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2341

Query: 923  LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 979
            L   L  +  ++      R    +++     Q  E      R  +E+   +         
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401

Query: 980  YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1035
            +  +  + +   + ++   S++A     +   +  ++A+   + E++LK   QA  E TR
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461

Query: 1036 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1079
            L    E   + K+ A E+ +R +E  E+   +L EET   Q+ +E E             
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521

Query: 1080 --VKIRERQRAQAR 1091
              +++ E  RAQAR
Sbjct: 2522 LKLRVAEMSRAQAR 2535



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)

Query: 600  KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
            K  E I E+    ELA  E  ++ ++  LE  +Q+     +++ E+  EL+ E   L  E
Sbjct: 2545 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2602

Query: 660  QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 704
             K     SE  + ++++++L          L+ K  + + E+ I  EK K   L   E  
Sbjct: 2603 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2662

Query: 705  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
              + L  +Q   + ++++E+    Q+L+  + E +R     +E +   +++   + QQ +
Sbjct: 2663 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2717

Query: 765  REQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
            R+Q+  + E+N      QR +E L  LE+++
Sbjct: 2718 RQQEELLAEEN------QRLREQLQLLEEQH 2742



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)

Query: 227  SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 286
            +MP +  QA +  ++   AL  ++ RH E   E      ++++   ++ +  Y   L   
Sbjct: 1372 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1425

Query: 287  YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 341
            Y+A   QL P++ P +       + + G + +    +D   +Y   ++L+S  + +    
Sbjct: 1426 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1477

Query: 342  -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 394
                   +  A +        L+   +    ++ L  + +   +    +A  +       
Sbjct: 1478 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1537

Query: 395  LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 438
            ++  E   V A ++  S         +  EA++++  RQA    +  LR          +
Sbjct: 1538 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1597

Query: 439  RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 492
             +++     G +  +   R + EE     R  ++E ERL RQ + E+     AE      
Sbjct: 1598 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1657

Query: 493  RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
              +      + Q+  + LE+L+L  EE+  E  L   +       + +L  A  ++   L
Sbjct: 1658 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1715

Query: 553  SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
                ASF         E  + L R            S +  ++++     E    E+R+Q
Sbjct: 1716 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1752

Query: 613  ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
            + A  E  R       EE +++++    + +E+ R L ++   +  ++     E  K+KE
Sbjct: 1753 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1804

Query: 673  ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
              +   R+  + E+  V ++      L+ + +  E         + RL  E+E +  +  
Sbjct: 1805 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1858

Query: 733  REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 788
             E  E QR ++  +E+++ L+++A    Q+ Q  +    K +  + ++L    + E+E+ 
Sbjct: 1859 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916

Query: 789  CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 846
               EK    L    G       L E    +  + E       L+   + +  A+A+ V  
Sbjct: 1917 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1973

Query: 847  EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 877
            E   A+           +A + +  E+              R LEE+  QHK  +     
Sbjct: 1974 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 2033

Query: 878  ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 918
                            + DTL +++       ++   F  A  G++   +  L LG+  S
Sbjct: 2034 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 2090

Query: 919  CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 969
                       + L  +        E RR        Q S    +++    + A E    
Sbjct: 2091 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150

Query: 970  LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1029
            L +        +++A      +S+  ++ +  A +   + +   ++   +++ E+ L+Q 
Sbjct: 2151 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2205

Query: 1030 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1083
              ++  +L+    E EA +RA EE +       RE  + R Q E ++R K   E++ + R
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2265

Query: 1084 ERQRAQARPLTR 1095
             + +A A  L +
Sbjct: 2266 AQAQAAAEKLRK 2277



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)

Query: 401  DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 460
            + + A + +F   +    E +LE  R  S        + ++ + +   R    +  RR+R
Sbjct: 2062 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 2121

Query: 461  EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 520
            E   R Q+             SL AE      R +    +E+V+++  ++E+ +   E +
Sbjct: 2122 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2165

Query: 521  VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 580
              E A      +    ++  L   + A   ++ Q        ++ + ++ + D  R    
Sbjct: 2166 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2218

Query: 581  PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 638
             +    +A+ E+    +  +     S  Q   ++ L    E +       +   +K++  
Sbjct: 2219 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2278

Query: 639  NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 698
             +Q  E+ R    E A L  +Q ++  E+ K K+  +   R+ A++E+ +   +      
Sbjct: 2279 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2329

Query: 699  LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 758
                      L+ ++ +H+  L +E+    Q+L  E  E  R     +E++ +++ Q   
Sbjct: 2330 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376

Query: 759  IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 814
            + + +A+ E ++    +++K+N    LQ E E +  + ++ + LS           L E 
Sbjct: 2377 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2436

Query: 815  YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 863
             ++         + E  +    +T L    +       +A E A  +   + Q  +    
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2496

Query: 864  ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 917
                  R+LE  +++  E    ++ L  K   + +S   + A        K    +G+  
Sbjct: 2497 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2554

Query: 918  SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 971
                +       + +  E +R    ++ +++ E   +      +   E+ +       + 
Sbjct: 2555 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2614

Query: 972  SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 1021
            +        + QA     L   DS+          +  +     D ++ A        EE
Sbjct: 2615 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2670

Query: 1022 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1081
             +R  +Q   E+ RL+ S E     +  A E  +R++E L++  Q+   Q + L E+  +
Sbjct: 2671 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2730

Query: 1082 IRER 1085
            +RE+
Sbjct: 2731 LREQ 2734



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)

Query: 419  EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 474
            EA+L+S R AS   + A  ER      ++      +  RR ++    ER RE+    LER
Sbjct: 1712 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770

Query: 475  QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 530
             +L+      L L AE       L+     +  ++  +E  +   ++E++V +  L   +
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830

Query: 531  TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 589
               +    +      LA+   L +  A   T +  +  +LL + L R     ++   K  
Sbjct: 1831 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1888

Query: 590  SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 649
               + L+ +    E +   +   E    EE+R    +  E+ KQ+++    +    FREL
Sbjct: 1889 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1936

Query: 650  DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 708
              E A L    ++   E  +++++ +    R+ AE E+ +  +     +   ++++    
Sbjct: 1937 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1992

Query: 709  LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 766
            L+ ++ E+E   RL E++    ++L  + A+++ +I   +E+++ L+K ++  +++ +  
Sbjct: 1993 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 2049

Query: 767  QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 826
             +  ++++  +       +E +  L+  +   + GK          E  + +  I     
Sbjct: 2050 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 2093

Query: 827  NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 885
            ++       +  A     +A E       ++ + ++   + EE  +Q K  L   + L  
Sbjct: 2094 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2153

Query: 886  KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 945
            K   +      +     R +  +      Q          + A   K+ E ++ L+    
Sbjct: 2154 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2209

Query: 946  QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 1005
            Q + +  R ++E   R A E+            + ++ A     ++ ++ ++ S    + 
Sbjct: 2210 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2263

Query: 1006 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1055
                + + +        E+L K+A  E  R  ++           + EME  K+  E+  
Sbjct: 2264 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315

Query: 1056 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1108
            R++  +E+ L       EET  ++ L+++E+   +R +A+A    R    V +E F +R 
Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2372

Query: 1109 HVE 1111
             +E
Sbjct: 2373 QME 2375



 Score = 34.3 bits (77), Expect = 0.76
 Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)

Query: 1020 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1066
            +E+E  L +  AE   LL S+ R  E  +   E+ K+R        RE+ E     + L 
Sbjct: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1947

Query: 1067 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1113
            EE  ++++L E++     RQRA+A R L   L    E   L++  E A
Sbjct: 1948 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1992


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)

Query: 416  EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 474
            E  E +LE  RQ A GT Q  L   +  I   +      +  + +++ +L E+E+ RL+R
Sbjct: 1666 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1719

Query: 475  Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 527
            +       R E    L     + +  L++    E+  +   E  K +L  E   F E L 
Sbjct: 1720 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1778

Query: 528  SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 585
                R R   +++     LA   +  Q + +         ++L  + + TR         
Sbjct: 1779 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1834

Query: 586  PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 645
             +  +E+  L  L +  +   + +R +E AA  +       ++EE   +++  +D   E 
Sbjct: 1835 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1886

Query: 646  FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 704
             + L +E  L    Q  E  E++  K   +      AELE  +   ++   D L   E  
Sbjct: 1887 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1943

Query: 705  HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 760
              E    +QL  E E R  E +E + + L    E A  ++  +   E++ A  ++A  + 
Sbjct: 1944 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2003

Query: 761  QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
            ++A++E    ++             EK +   + Q+E+E    L+++ S L   +G    
Sbjct: 2004 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2063

Query: 808  PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 865
                 E      V    E   +   +  + +    A+  A   A A  A++   KE  + 
Sbjct: 2064 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2123

Query: 866  LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 922
               R +  +  L     +D    K    +       A + + +T    L L +++   ++
Sbjct: 2124 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2182

Query: 923  LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 979
            L   L  +  ++      R    +++     Q  E      R  +E+   +         
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242

Query: 980  YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1035
            +  +  + +   + ++   S++A     +   +  ++A+   + E++LK   QA  E TR
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302

Query: 1036 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1079
            L    E   + K+ A E+ +R +E  E+   +L EET   Q+ +E E             
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362

Query: 1080 --VKIRERQRAQAR 1091
              +++ E  RAQAR
Sbjct: 2363 LKLRVAEMSRAQAR 2376



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)

Query: 600  KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
            K  E I E+    ELA  E  ++ ++  LE  +Q+     +++ E+  EL+ E   L  E
Sbjct: 2386 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2443

Query: 660  QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 704
             K     SE  + ++++++L          L+ K  + + E+ I  EK K   L   E  
Sbjct: 2444 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2503

Query: 705  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
              + L  +Q   + ++++E+    Q+L+  + E +R     +E +   +++   + QQ +
Sbjct: 2504 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2558

Query: 765  REQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
            R+Q+  + E+N      QR +E L  LE+++
Sbjct: 2559 RQQEELLAEEN------QRLREQLQLLEEQH 2583



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)

Query: 227  SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 286
            +MP +  QA +  ++   AL  ++ RH E   E      ++++   ++ +  Y   L   
Sbjct: 1213 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1266

Query: 287  YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 341
            Y+A   QL P++ P +       + + G + +    +D   +Y   ++L+S  + +    
Sbjct: 1267 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1318

Query: 342  -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 394
                   +  A +        L+   +    ++ L  + +   +    +A  +       
Sbjct: 1319 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1378

Query: 395  LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 438
            ++  E   V A ++  S         +  EA++++  RQA    +  LR          +
Sbjct: 1379 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1438

Query: 439  RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 492
             +++     G +  +   R + EE     R  ++E ERL RQ + E+     AE      
Sbjct: 1439 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1498

Query: 493  RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
              +      + Q+  + LE+L+L  EE+  E  L   +       + +L  A  ++   L
Sbjct: 1499 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1556

Query: 553  SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
                ASF         E  + L R            S +  ++++     E    E+R+Q
Sbjct: 1557 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1593

Query: 613  ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
            + A  E  R       EE +++++    + +E+ R L ++   +  ++     E  K+KE
Sbjct: 1594 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1645

Query: 673  ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
              +   R+  + E+  V ++      L+ + +  E         + RL  E+E +  +  
Sbjct: 1646 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1699

Query: 733  REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 788
             E  E QR ++  +E+++ L+++A    Q+ Q  +    K +  + ++L    + E+E+ 
Sbjct: 1700 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757

Query: 789  CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 846
               EK    L    G       L E    +  + E       L+   + +  A+A+ V  
Sbjct: 1758 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1814

Query: 847  EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 877
            E   A+           +A + +  E+              R LEE+  QHK  +     
Sbjct: 1815 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1874

Query: 878  ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 918
                            + DTL +++       ++   F  A  G++   +  L LG+  S
Sbjct: 1875 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1931

Query: 919  CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 969
                       + L  +        E RR        Q S    +++    + A E    
Sbjct: 1932 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991

Query: 970  LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1029
            L +        +++A      +S+  ++ +  A +   + +   ++   +++ E+ L+Q 
Sbjct: 1992 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2046

Query: 1030 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1083
              ++  +L+    E EA +RA EE +       RE  + R Q E ++R K   E++ + R
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2106

Query: 1084 ERQRAQARPLTR 1095
             + +A A  L +
Sbjct: 2107 AQAQAAAEKLRK 2118



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)

Query: 401  DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 460
            + + A + +F   +    E +LE  R  S        + ++ + +   R    +  RR+R
Sbjct: 1903 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1962

Query: 461  EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 520
            E   R Q+             SL AE      R +    +E+V+++  ++E+ +   E +
Sbjct: 1963 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2006

Query: 521  VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 580
              E A      +    ++  L   + A   ++ Q        ++ + ++ + D  R    
Sbjct: 2007 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2059

Query: 581  PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 638
             +    +A+ E+    +  +     S  Q   ++ L    E +       +   +K++  
Sbjct: 2060 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2119

Query: 639  NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 698
             +Q  E+ R    E A L  +Q ++  E+ K K+  +   R+ A++E+ +   +      
Sbjct: 2120 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2170

Query: 699  LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 758
                      L+ ++ +H+  L +E+    Q+L  E  E  R     +E++ +++ Q   
Sbjct: 2171 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217

Query: 759  IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 814
            + + +A+ E ++    +++K+N    LQ E E +  + ++ + LS           L E 
Sbjct: 2218 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2277

Query: 815  YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 863
             ++         + E  +    +T L    +       +A E A  +   + Q  +    
Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2337

Query: 864  ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 917
                  R+LE  +++  E    ++ L  K   + +S   + A        K    +G+  
Sbjct: 2338 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2395

Query: 918  SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 971
                +       + +  E +R    ++ +++ E   +      +   E+ +       + 
Sbjct: 2396 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2455

Query: 972  SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 1021
            +        + QA     L   DS+          +  +     D ++ A        EE
Sbjct: 2456 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2511

Query: 1022 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1081
             +R  +Q   E+ RL+ S E     +  A E  +R++E L++  Q+   Q + L E+  +
Sbjct: 2512 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2571

Query: 1082 IRER 1085
            +RE+
Sbjct: 2572 LREQ 2575



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)

Query: 419  EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 474
            EA+L+S R AS   + A  ER      ++      +  RR ++    ER RE+    LER
Sbjct: 1553 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611

Query: 475  QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 530
             +L+      L L AE       L+     +  ++  +E  +   ++E++V +  L   +
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671

Query: 531  TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 589
               +    +      LA+   L +  A   T +  +  +LL + L R     ++   K  
Sbjct: 1672 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1729

Query: 590  SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 649
               + L+ +    E +   +   E    EE+R    +  E+ KQ+++    +    FREL
Sbjct: 1730 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1777

Query: 650  DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 708
              E A L    ++   E  +++++ +    R+ AE E+ +  +     +   ++++    
Sbjct: 1778 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1833

Query: 709  LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 766
            L+ ++ E+E   RL E++    ++L  + A+++ +I   +E+++ L+K ++  +++ +  
Sbjct: 1834 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1890

Query: 767  QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 826
             +  ++++  +       +E +  L+  +   + GK          E  + +  I     
Sbjct: 1891 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1934

Query: 827  NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 885
            ++       +  A     +A E       ++ + ++   + EE  +Q K  L   + L  
Sbjct: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1994

Query: 886  KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 945
            K   +      +     R +  +      Q          + A   K+ E ++ L+    
Sbjct: 1995 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2050

Query: 946  QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 1005
            Q + +  R ++E   R A E+            + ++ A     ++ ++ ++ S    + 
Sbjct: 2051 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2104

Query: 1006 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1055
                + + +        E+L K+A  E  R  ++           + EME  K+  E+  
Sbjct: 2105 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156

Query: 1056 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1108
            R++  +E+ L       EET  ++ L+++E+   +R +A+A    R    V +E F +R 
Sbjct: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2213

Query: 1109 HVE 1111
             +E
Sbjct: 2214 QME 2216



 Score = 34.3 bits (77), Expect = 0.76
 Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)

Query: 1020 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1066
            +E+E  L +  AE   LL S+ R  E  +   E+ K+R        RE+ E     + L 
Sbjct: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1788

Query: 1067 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1113
            EE  ++++L E++     RQRA+A R L   L    E   L++  E A
Sbjct: 1789 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1833


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)

Query: 416  EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 474
            E  E +LE  RQ A GT Q  L   +  I   +      +  + +++ +L E+E+ RL+R
Sbjct: 1674 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1727

Query: 475  Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 527
            +       R E    L     + +  L++    E+  +   E  K +L  E   F E L 
Sbjct: 1728 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1786

Query: 528  SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 585
                R R   +++     LA   +  Q + +         ++L  + + TR         
Sbjct: 1787 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1842

Query: 586  PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 645
             +  +E+  L  L +  +   + +R +E AA  +       ++EE   +++  +D   E 
Sbjct: 1843 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1894

Query: 646  FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 704
             + L +E  L    Q  E  E++  K   +      AELE  +   ++   D L   E  
Sbjct: 1895 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1951

Query: 705  HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 760
              E    +QL  E E R  E +E + + L    E A  ++  +   E++ A  ++A  + 
Sbjct: 1952 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2011

Query: 761  QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
            ++A++E    ++             EK +   + Q+E+E    L+++ S L   +G    
Sbjct: 2012 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2071

Query: 808  PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 865
                 E      V    E   +   +  + +    A+  A   A A  A++   KE  + 
Sbjct: 2072 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2131

Query: 866  LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 922
               R +  +  L     +D    K    +       A + + +T    L L +++   ++
Sbjct: 2132 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2190

Query: 923  LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 979
            L   L  +  ++      R    +++     Q  E      R  +E+   +         
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250

Query: 980  YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1035
            +  +  + +   + ++   S++A     +   +  ++A+   + E++LK   QA  E TR
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310

Query: 1036 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1079
            L    E   + K+ A E+ +R +E  E+   +L EET   Q+ +E E             
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370

Query: 1080 --VKIRERQRAQAR 1091
              +++ E  RAQAR
Sbjct: 2371 LKLRVAEMSRAQAR 2384



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)

Query: 600  KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 659
            K  E I E+    ELA  E  ++ ++  LE  +Q+     +++ E+  EL+ E   L  E
Sbjct: 2394 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2451

Query: 660  QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 704
             K     SE  + ++++++L          L+ K  + + E+ I  EK K   L   E  
Sbjct: 2452 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2511

Query: 705  HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
              + L  +Q   + ++++E+    Q+L+  + E +R     +E +   +++   + QQ +
Sbjct: 2512 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2566

Query: 765  REQDHFVKEKNNLIMMLQREKENLCNLEKKY 795
            R+Q+  + E+N      QR +E L  LE+++
Sbjct: 2567 RQQEELLAEEN------QRLREQLQLLEEQH 2591



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)

Query: 227  SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 286
            +MP +  QA +  ++   AL  ++ RH E   E      ++++   ++ +  Y   L   
Sbjct: 1221 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1274

Query: 287  YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 341
            Y+A   QL P++ P +       + + G + +    +D   +Y   ++L+S  + +    
Sbjct: 1275 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1326

Query: 342  -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 394
                   +  A +        L+   +    ++ L  + +   +    +A  +       
Sbjct: 1327 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1386

Query: 395  LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 438
            ++  E   V A ++  S         +  EA++++  RQA    +  LR          +
Sbjct: 1387 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1446

Query: 439  RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 492
             +++     G +  +   R + EE     R  ++E ERL RQ + E+     AE      
Sbjct: 1447 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1506

Query: 493  RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
              +      + Q+  + LE+L+L  EE+  E  L   +       + +L  A  ++   L
Sbjct: 1507 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1564

Query: 553  SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
                ASF         E  + L R            S +  ++++     E    E+R+Q
Sbjct: 1565 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1601

Query: 613  ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
            + A  E  R       EE +++++    + +E+ R L ++   +  ++     E  K+KE
Sbjct: 1602 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1653

Query: 673  ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
              +   R+  + E+  V ++      L+ + +  E         + RL  E+E +  +  
Sbjct: 1654 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1707

Query: 733  REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 788
             E  E QR ++  +E+++ L+++A    Q+ Q  +    K +  + ++L    + E+E+ 
Sbjct: 1708 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765

Query: 789  CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 846
               EK    L    G       L E    +  + E       L+   + +  A+A+ V  
Sbjct: 1766 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1822

Query: 847  EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 877
            E   A+           +A + +  E+              R LEE+  QHK  +     
Sbjct: 1823 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1882

Query: 878  ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 918
                            + DTL +++       ++   F  A  G++   +  L LG+  S
Sbjct: 1883 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1939

Query: 919  CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 969
                       + L  +        E RR        Q S    +++    + A E    
Sbjct: 1940 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1999

Query: 970  LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1029
            L +        +++A      +S+  ++ +  A +   + +   ++   +++ E+ L+Q 
Sbjct: 2000 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2054

Query: 1030 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1083
              ++  +L+    E EA +RA EE +       RE  + R Q E ++R K   E++ + R
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2114

Query: 1084 ERQRAQARPLTR 1095
             + +A A  L +
Sbjct: 2115 AQAQAAAEKLRK 2126



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)

Query: 401  DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 460
            + + A + +F   +    E +LE  R  S        + ++ + +   R    +  RR+R
Sbjct: 1911 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1970

Query: 461  EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 520
            E   R Q+             SL AE      R +    +E+V+++  ++E+ +   E +
Sbjct: 1971 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2014

Query: 521  VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 580
              E A      +    ++  L   + A   ++ Q        ++ + ++ + D  R    
Sbjct: 2015 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2067

Query: 581  PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 638
             +    +A+ E+    +  +     S  Q   ++ L    E +       +   +K++  
Sbjct: 2068 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2127

Query: 639  NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 698
             +Q  E+ R    E A L  +Q ++  E+ K K+  +   R+ A++E+ +   +      
Sbjct: 2128 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2178

Query: 699  LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 758
                      L+ ++ +H+  L +E+    Q+L  E  E  R     +E++ +++ Q   
Sbjct: 2179 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2225

Query: 759  IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 814
            + + +A+ E ++    +++K+N    LQ E E +  + ++ + LS           L E 
Sbjct: 2226 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2285

Query: 815  YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 863
             ++         + E  +    +T L    +       +A E A  +   + Q  +    
Sbjct: 2286 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2345

Query: 864  ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 917
                  R+LE  +++  E    ++ L  K   + +S   + A        K    +G+  
Sbjct: 2346 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2403

Query: 918  SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 971
                +       + +  E +R    ++ +++ E   +      +   E+ +       + 
Sbjct: 2404 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2463

Query: 972  SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 1021
            +        + QA     L   DS+          +  +     D ++ A        EE
Sbjct: 2464 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2519

Query: 1022 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1081
             +R  +Q   E+ RL+ S E     +  A E  +R++E L++  Q+   Q + L E+  +
Sbjct: 2520 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2579

Query: 1082 IRER 1085
            +RE+
Sbjct: 2580 LREQ 2583



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)

Query: 419  EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 474
            EA+L+S R AS   + A  ER      ++      +  RR ++    ER RE+    LER
Sbjct: 1561 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619

Query: 475  QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 530
             +L+      L L AE       L+     +  ++  +E  +   ++E++V +  L   +
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1679

Query: 531  TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 589
               +    +      LA+   L +  A   T +  +  +LL + L R     ++   K  
Sbjct: 1680 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1737

Query: 590  SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 649
               + L+ +    E +   +   E    EE+R    +  E+ KQ+++    +    FREL
Sbjct: 1738 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1785

Query: 650  DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 708
              E A L    ++   E  +++++ +    R+ AE E+ +  +     +   ++++    
Sbjct: 1786 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1841

Query: 709  LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 766
            L+ ++ E+E   RL E++    ++L  + A+++ +I   +E+++ L+K ++  +++ +  
Sbjct: 1842 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1898

Query: 767  QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 826
             +  ++++  +       +E +  L+  +   + GK          E  + +  I     
Sbjct: 1899 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1942

Query: 827  NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 885
            ++       +  A     +A E       ++ + ++   + EE  +Q K  L   + L  
Sbjct: 1943 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2002

Query: 886  KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 945
            K   +      +     R +  +      Q          + A   K+ E ++ L+    
Sbjct: 2003 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2058

Query: 946  QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 1005
            Q + +  R ++E   R A E+            + ++ A     ++ ++ ++ S    + 
Sbjct: 2059 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2112

Query: 1006 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1055
                + + +        E+L K+A  E  R  ++           + EME  K+  E+  
Sbjct: 2113 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164

Query: 1056 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1108
            R++  +E+ L       EET  ++ L+++E+   +R +A+A    R    V +E F +R 
Sbjct: 2165 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2221

Query: 1109 HVE 1111
             +E
Sbjct: 2222 QME 2224



 Score = 34.3 bits (77), Expect = 0.76
 Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)

Query: 1020 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1066
            +E+E  L +  AE   LL S+ R  E  +   E+ K+R        RE+ E     + L 
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1796

Query: 1067 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1113
            EE  ++++L E++     RQRA+A R L   L    E   L++  E A
Sbjct: 1797 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1841


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.126    0.348 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,136,678
Number of Sequences: 37866
Number of extensions: 2345914
Number of successful extensions: 21841
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 310
Number of HSP's successfully gapped in prelim test: 893
Number of HSP's that attempted gapping in prelim test: 12033
Number of HSP's gapped (non-prelim): 8072
length of query: 1237
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1123
effective length of database: 13,930,794
effective search space: 15644281662
effective search space used: 15644281662
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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