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Search of human proteins with 19718741
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo
sapiens]
(950 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo sa... 1942 0.0
gi|19718746 oxysterol-binding protein-like 1A isoform A [Homo sa... 914 0.0
gi|21450853 oxysterol-binding protein-like protein 2 isoform 2 [... 677 0.0
gi|7662298 oxysterol-binding protein-like protein 2 isoform 1 [H... 677 0.0
gi|13540513 oxysterol binding protein 2 isoform a [Homo sapiens] 335 1e-91
gi|4505531 oxysterol binding protein [Homo sapiens] 331 2e-90
gi|21735580 oxysterol-binding protein-like protein 3 isoform b [... 296 5e-80
gi|14149704 oxysterol-binding protein-like protein 3 isoform a [... 296 5e-80
gi|21735584 oxysterol-binding protein-like protein 3 isoform d [... 296 6e-80
gi|21735582 oxysterol-binding protein-like protein 3 isoform c [... 296 6e-80
gi|22035612 oxysterol-binding protein-like protein 6 isoform b [... 295 2e-79
gi|14210532 oxysterol-binding protein-like protein 6 isoform a [... 295 2e-79
gi|22035616 oxysterol-binding protein-like protein 7 [Homo sapiens] 286 6e-77
gi|22547173 oxysterol binding protein-like 9 isoform d [Homo sap... 164 5e-40
gi|20070331 oxysterol binding protein-like 9 isoform e [Homo sap... 156 1e-37
gi|22547176 oxysterol binding protein-like 9 isoform f [Homo sap... 155 2e-37
gi|51243032 oxysterol-binding protein-like protein 8 isoform b [... 142 1e-33
gi|18079218 oxysterol-binding protein-like protein 8 isoform a [... 142 1e-33
gi|14149740 oxysterol-binding protein-like protein 5 isoform a [... 139 2e-32
gi|221136766 oxysterol-binding protein-like protein 5 isoform b ... 139 2e-32
gi|22035609 oxysterol-binding protein-like protein 5 isoform b [... 139 2e-32
gi|22547171 oxysterol binding protein-like 9 isoform c [Homo sap... 137 6e-32
gi|22547167 oxysterol binding protein-like 9 isoform a [Homo sap... 132 2e-30
gi|22547165 oxysterol binding protein-like 9 isoform a [Homo sap... 132 2e-30
gi|22547169 oxysterol binding protein-like 9 isoform b [Homo sap... 130 6e-30
gi|19923592 oxysterol binding protein-like 11 [Homo sapiens] 110 5e-24
gi|19923812 oxysterol-binding protein-like protein 10 [Homo sapi... 108 2e-23
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 100 8e-21
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 97 9e-20
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 91 5e-18
>gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo
sapiens]
Length = 950
Score = 1942 bits (5031), Expect = 0.0
Identities = 950/950 (100%), Positives = 950/950 (100%)
Query: 1 MNTEAEQQLLHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGH 60
MNTEAEQQLLHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGH
Sbjct: 1 MNTEAEQQLLHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGH 60
Query: 61 RQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEV 120
RQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEV
Sbjct: 61 RQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEV 120
Query: 121 THAEEIRSMLEAVERTQQRKLEELLLAAAREGKTTELTALLNRPNPPDVNCSDQLGNTPL 180
THAEEIRSMLEAVERTQQRKLEELLLAAAREGKTTELTALLNRPNPPDVNCSDQLGNTPL
Sbjct: 121 THAEEIRSMLEAVERTQQRKLEELLLAAAREGKTTELTALLNRPNPPDVNCSDQLGNTPL 180
Query: 181 HCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQGAEMKHILVGNKVIYKALKRYEG 240
HCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQGAEMKHILVGNKVIYKALKRYEG
Sbjct: 181 HCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQGAEMKHILVGNKVIYKALKRYEG 240
Query: 241 PLWKSSRFFGWRLFWVVLEHGVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKSTDSCLFF 300
PLWKSSRFFGWRLFWVVLEHGVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKSTDSCLFF
Sbjct: 241 PLWKSSRFFGWRLFWVVLEHGVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKSTDSCLFF 300
Query: 301 IKCFDDTIHGFRVPKNSLQQSREDWLEAIEEHSAYSTHYCSQDQLTDEEEEDTVSAADLK 360
IKCFDDTIHGFRVPKNSLQQSREDWLEAIEEHSAYSTHYCSQDQLTDEEEEDTVSAADLK
Sbjct: 301 IKCFDDTIHGFRVPKNSLQQSREDWLEAIEEHSAYSTHYCSQDQLTDEEEEDTVSAADLK 360
Query: 361 KSLEKAQSCQQRLDREISNFLKMIKECDMAKEMLPSFLQKVEVVSEASRETCVALTDCLN 420
KSLEKAQSCQQRLDREISNFLKMIKECDMAKEMLPSFLQKVEVVSEASRETCVALTDCLN
Sbjct: 361 KSLEKAQSCQQRLDREISNFLKMIKECDMAKEMLPSFLQKVEVVSEASRETCVALTDCLN 420
Query: 421 LFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELEQSLVKGSPPASILSEDEFYDAL 480
LFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELEQSLVKGSPPASILSEDEFYDAL
Sbjct: 421 LFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELEQSLVKGSPPASILSEDEFYDAL 480
Query: 481 SDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSP 540
SDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSP
Sbjct: 481 SDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSP 540
Query: 541 MFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPV 600
MFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPV
Sbjct: 541 MFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPV 600
Query: 601 ERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHA 660
ERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHA
Sbjct: 601 ERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHA 660
Query: 661 EGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKL 720
EGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKL
Sbjct: 661 EGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKL 720
Query: 721 WIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLY 780
WIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLY
Sbjct: 721 WIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLY 780
Query: 781 SVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRP 840
SVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRP
Sbjct: 781 SVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRP 840
Query: 841 PNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQ 900
PNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQ
Sbjct: 841 PNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQ 900
Query: 901 RAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSYWDRNYFNLPDIY 950
RAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSYWDRNYFNLPDIY
Sbjct: 901 RAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSYWDRNYFNLPDIY 950
>gi|19718746 oxysterol-binding protein-like 1A isoform A [Homo
sapiens]
Length = 437
Score = 914 bits (2363), Expect = 0.0
Identities = 437/437 (100%), Positives = 437/437 (100%)
Query: 514 MSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEP 573
MSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEP
Sbjct: 1 MSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEP 60
Query: 574 LSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETY 633
LSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETY
Sbjct: 61 LSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETY 120
Query: 634 ELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTIT 693
ELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTIT
Sbjct: 121 ELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTIT 180
Query: 694 LELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKEL 753
LELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKEL
Sbjct: 181 LELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKEL 240
Query: 754 HKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEEL 813
HKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEEL
Sbjct: 241 HKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEEL 300
Query: 814 DEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCR 873
DEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCR
Sbjct: 301 DEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCR 360
Query: 874 LRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWI 933
LRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWI
Sbjct: 361 LRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWI 420
Query: 934 YSGSYWDRNYFNLPDIY 950
YSGSYWDRNYFNLPDIY
Sbjct: 421 YSGSYWDRNYFNLPDIY 437
>gi|21450853 oxysterol-binding protein-like protein 2 isoform 2
[Homo sapiens]
Length = 480
Score = 677 bits (1748), Expect = 0.0
Identities = 316/488 (64%), Positives = 388/488 (79%), Gaps = 21/488 (4%)
Query: 473 EDEFYDALSDSESERSLSRLEAVTARSF------EEEGEHLGSRKHRMSEEKDCGGGDAL 526
E+EF+DA++ +S+ S + + +G R S+E
Sbjct: 4 EEEFFDAVTGFDSDNSSGEFSEANQKVTGMIDLDTSKNNRIGKTGERPSQE--------- 54
Query: 527 SNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEH 586
NGI+KHRTSLP+PMFSR+DFS+W+IL+KC+G+ELSKITMP+ FNEPLSFLQR+TEYMEH
Sbjct: 55 -NGIQKHRTSLPAPMFSRSDFSVWTILKKCVGLELSKITMPIAFNEPLSFLQRITEYMEH 113
Query: 587 TYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLIS 646
YLIH+AS P+ERMQ VAAFAVSAVASQWERTGKPFNPLLGETYEL+R+DLGFR IS
Sbjct: 114 VYLIHRASCQPQPLERMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFIS 173
Query: 647 EQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWT 706
EQVSHHPPISAFH+EGLN+DF+FHGSIYPKLKFWGKSVEAEP+GTITLELL+HNEAYTWT
Sbjct: 174 EQVSHHPPISAFHSEGLNHDFLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWT 233
Query: 707 NPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKK 766
NPTCCVHN+I+GKLWIEQYG VEI+NH+TG KCVL+FKPCGLFGKELHKVEG+IQDK+KK
Sbjct: 234 NPTCCVHNVIIGKLWIEQYGTVEILNHRTGHKCVLHFKPCGLFGKELHKVEGHIQDKNKK 293
Query: 767 KLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKK----NSKQMSTSEELDEMPVPDSE 822
KL +YGKWTECL+ +DP +++++KK +++ +K + S+ D++PV E
Sbjct: 294 KLFMIYGKWTECLWGIDPVSYESFKKQERRGDHLRKAKLDEDSGKADSDVADDVPVA-QE 352
Query: 823 SVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAME 882
+V +IPGS LLWRI RPPNSAQMYNFTSF + LNE++ ME +P TDCRLRPDIR ME
Sbjct: 353 TVQVIPGSKLLWRINTRPPNSAQMYNFTSFTVSLNELETGMEKTLPPTDCRLRPDIRGME 412
Query: 883 NGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSYWDRN 942
NG +D AS+EK+RLEEKQR AR+ R+K E +W+TRWF+ G NPY G DW+Y+G Y++RN
Sbjct: 413 NGNMDLASQEKERLEEKQREARRERAKEEAEWQTRWFYPGNNPYTGTPDWLYAGDYFERN 472
Query: 943 YFNLPDIY 950
+ + PDIY
Sbjct: 473 FSDCPDIY 480
>gi|7662298 oxysterol-binding protein-like protein 2 isoform 1 [Homo
sapiens]
Length = 468
Score = 677 bits (1747), Expect = 0.0
Identities = 315/482 (65%), Positives = 393/482 (81%), Gaps = 21/482 (4%)
Query: 473 EDEFYDALSDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKK 532
E+EF+DA++++ +++ ++ T+++ +G R S+E NGI+K
Sbjct: 4 EEEFFDAVTEA-NQKVTGMIDLDTSKN-----NRIGKTGERPSQE----------NGIQK 47
Query: 533 HRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHK 592
HRTSLP+PMFSR+DFS+W+IL+KC+G+ELSKITMP+ FNEPLSFLQR+TEYMEH YLIH+
Sbjct: 48 HRTSLPAPMFSRSDFSVWTILKKCVGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHR 107
Query: 593 ASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHH 652
AS P+ERMQ VAAFAVSAVASQWERTGKPFNPLLGETYEL+R+DLGFR ISEQVSHH
Sbjct: 108 ASCQPQPLERMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHH 167
Query: 653 PPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCV 712
PPISAFH+EGLN+DF+FHGSIYPKLKFWGKSVEAEP+GTITLELL+HNEAYTWTNPTCCV
Sbjct: 168 PPISAFHSEGLNHDFLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCV 227
Query: 713 HNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALY 772
HN+I+GKLWIEQYG VEI+NH+TG KCVL+FKPCGLFGKELHKVEG+IQDK+KKKL +Y
Sbjct: 228 HNVIIGKLWIEQYGTVEILNHRTGHKCVLHFKPCGLFGKELHKVEGHIQDKNKKKLFMIY 287
Query: 773 GKWTECLYSVDPATFDAYKKNDKKNTEEKK----NSKQMSTSEELDEMPVPDSESVFIIP 828
GKWTECL+ +DP +++++KK +++ +K + S+ D++PV E+V +IP
Sbjct: 288 GKWTECLWGIDPVSYESFKKQERRGDHLRKAKLDEDSGKADSDVADDVPVA-QETVQVIP 346
Query: 829 GSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQ 888
GS LLWRI RPPNSAQMYNFTSF + LNE++ ME +P TDCRLRPDIR MENG +D
Sbjct: 347 GSKLLWRINTRPPNSAQMYNFTSFTVSLNELETGMEKTLPPTDCRLRPDIRGMENGNMDL 406
Query: 889 ASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSYWDRNYFNLPD 948
AS+EK+RLEEKQR AR+ R+K E +W+TRWF+ G NPY G DW+Y+G Y++RN+ + PD
Sbjct: 407 ASQEKERLEEKQREARRERAKEEAEWQTRWFYPGNNPYTGTPDWLYAGDYFERNFSDCPD 466
Query: 949 IY 950
IY
Sbjct: 467 IY 468
>gi|13540513 oxysterol binding protein 2 isoform a [Homo sapiens]
Length = 916
Score = 335 bits (859), Expect = 1e-91
Identities = 252/766 (32%), Positives = 366/766 (47%), Gaps = 105/766 (13%)
Query: 235 LKRYEGPLWKSSRFF-GWRLFWVVLEHGVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKS 293
L +EG L K + + G++ W VL +G+LS+YR Q + H +G +L+ A + +
Sbjct: 182 LDSFEGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQGEMAHTC--RGTINLSTA--HIDT 237
Query: 294 TDSCLFFIKCFDDTIHGFRVPKNSLQQSREDWLEAIEEHSAYSTHYCSQDQLTDEEEEDT 353
DSC + + H K S + R+ W+ A+E A + + ++++
Sbjct: 238 EDSCGILLTSGARSYH----LKASSEVDRQQWITALELAKAKAVRVMNTHSDDSGDDDEA 293
Query: 354 VSAAD----------LKKSLEKAQSCQQRLDREISNFLKMIKECDMAKEMLPSFL-QKVE 402
+ AD L L+ +C + + + + + E D K +PS +K++
Sbjct: 294 TTPADKSELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSLTELDGLK--IPSESGEKLK 351
Query: 403 VVSEAS---RETCVALTDCLNLFTKQEGVRNFK----LEQEQEKNKILSEALETLATEHH 455
VV+E + R T A+ + F + + + K L+ EQE+ L E +E LA +H+
Sbjct: 352 VVNERATLFRITSNAMINACRDFLELAEIHSRKWQRALQYEQEQRVHLEETIEQLAKQHN 411
Query: 456 ELEQ--------------SLVKGS---PPASILSEDE---FYDALSDSESERSLSRLEAV 495
LE+ S ++GS P EDE ++DA+ DS S ++ +
Sbjct: 412 SLERAFHSAPGRPANPSKSFIEGSLLTPKGEDSEEDEDTEYFDAMEDSTS--FITVITEA 469
Query: 496 TARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRK 555
S + EG S S + G + G K + + P ++WSI++
Sbjct: 470 KEDSRKAEGSTGTSSVDWSSADNVLDGASLVPKGSSKVKRRVRIPNKPNYSLNLWSIMKN 529
Query: 556 CIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVA 615
CIG ELS+I MPV FNEPLS LQRLTE +E+ +L+ KA + VE+M VAAF+VS+ +
Sbjct: 530 CIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAAFSVSSYS 589
Query: 616 SQWERTGKPFNPLLGETYELVR-DDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIY 674
+ R KPFNP+LGET+EL R DD+G R + EQVSHHPP SA H + + I
Sbjct: 590 TTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPP-SAAHYVFSKHGWSLWQEIT 648
Query: 675 PKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHK 734
KF GK + P G I LE Y W T VHNIIVGKLWI+Q G++EI+NHK
Sbjct: 649 ISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHK 708
Query: 735 TGDKCVLNFKPCGLFGKE-LHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKN 793
T D+C L F P F KE KV G + D K L G W E
Sbjct: 709 TNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDE---------------- 752
Query: 794 DKKNTEEKKNSKQMSTSEELDEMPVPDS-----ESVFIIPGSVLLWRIAPRPPNSAQMYN 848
QM S+ + P S ++V+ + LLW+ P P N+ MY
Sbjct: 753 ------------QMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYY 800
Query: 849 FTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNR- 907
F+ A+ LNE + E V P TD RLRPD R ME G D+A+ EK+RLEEKQR +R+ R
Sbjct: 801 FSELALTLNEHE---EGVAP-TDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRL 856
Query: 908 -------------SKSEEDWKTRWFHQGPNPYNGAQDWIYSGSYWD 940
K + + WF + +P G +Y G YW+
Sbjct: 857 EACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGYWE 902
>gi|4505531 oxysterol binding protein [Homo sapiens]
Length = 807
Score = 331 bits (848), Expect = 2e-90
Identities = 258/770 (33%), Positives = 372/770 (48%), Gaps = 112/770 (14%)
Query: 239 EGPLWKSSRFF-GWRLFWVVLEHGVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKSTDSC 297
EG L+K + + G++ W VL +G+LS+YR + + H +G +L A TV+ DSC
Sbjct: 92 EGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTC--RGTINLATANITVE--DSC 147
Query: 298 LFFIKCFDDTIHGFRVPKNSLQQSREDWLEAIEEHSAYSTHYCSQ-DQLTDEEEEDTVSA 356
F I + K S + R+ W+ A+E A + ++ D+ DEE
Sbjct: 148 NFIISNGGAQTYHL---KASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDK 204
Query: 357 ADLKKSL-------EKAQSCQQRLDREISNFLKMIKECDMAKEMLPSFLQKVEVVSE--- 406
+L+ +L E +C + + + + + E + K S +K++ V+E
Sbjct: 205 TELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESN-EKIKQVNERAT 263
Query: 407 ----ASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELEQS-- 460
S A D L L L+ E+++ L E LE LA +H+ LE++
Sbjct: 264 LFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFR 323
Query: 461 ---LVKGSPPASILS-----------------EDEFYDALSDSESERSLSRLEAVTARSF 500
++ + P ++ S E+EF+DA +L + S
Sbjct: 324 GATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISG 383
Query: 501 EEEGEHLGSR-KHRMSEEKDCGGGDALSNGIKKHRTSLP-SPMFSRNDFSIWSILRKCIG 558
L + KH++ E K K+ RT +P P +S N +WSI++ CIG
Sbjct: 384 ASSDISLDEQYKHQLEETK------------KEKRTRIPYKPNYSLN---LWSIMKNCIG 428
Query: 559 MELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQW 618
ELSKI MPV FNEPLS LQRLTE +E+ L+ +A+ + +E++ VAAF VS+ ++
Sbjct: 429 KELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTV 488
Query: 619 ERTGKPFNPLLGETYELVR-DDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKL 677
RT KPFNPLLGET+EL R ++ G+R + EQVSHHPP +A HAE N + I
Sbjct: 489 FRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAES-KNGWTLRQEIKITS 547
Query: 678 KFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGD 737
KF GK + P GTI YTW T VHNIIVGKLWI+Q G ++I+NHKTGD
Sbjct: 548 KFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGD 607
Query: 738 KCVLNFKPCGLFGKEL-HKVEGYIQDKSKKKLCALYGKWTECL--YSVDPATFDAYKKND 794
KC L F P F +++ KV G + D S K AL G W E + + V P
Sbjct: 608 KCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVI-------- 659
Query: 795 KKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAM 854
E +++Q E V+LW+ P P N+ MY F+ A+
Sbjct: 660 ---GENGGDARQRGHEAE---------------ESRVMLWKRNPLPKNAENMYYFSELAL 701
Query: 855 VLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRS----KS 910
LN ES TD RLRPD R MENG D+A+ EK+RLEEKQR +RK R K+
Sbjct: 702 TLNA----WESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKA 757
Query: 911 EED------WKTRWFHQGPNPYNGAQDWIYSGSYWD----RNYFNLPDIY 950
ED +K WF + +P IY G YW+ +++ + PDI+
Sbjct: 758 TEDGTPYDPYKALWFERKKDPVTKELTHIYRGEYWECKEKQDWSSCPDIF 807
>gi|21735580 oxysterol-binding protein-like protein 3 isoform b
[Homo sapiens]
Length = 856
Score = 296 bits (759), Expect = 5e-80
Identities = 181/519 (34%), Positives = 268/519 (51%), Gaps = 78/519 (15%)
Query: 430 NFKLEQEQEKNKILSEALETLA--------TEHHELEQSLVKGSPPASILSEDEFYDALS 481
N E +++N+ L L + +E + ++ L+ S + +S+D+ Y +S
Sbjct: 388 NLAEENSRDENRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSY--VS 445
Query: 482 DSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSPM 541
D SL L + + E + LG E K + RT LP+P
Sbjct: 446 DISDNLSLDNL----SNDLDNERQTLGPVLDSGREAKS------------RRRTCLPAPC 489
Query: 542 FSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVE 601
S ++ S+W+ILR IG +LSK+ MPV NEPL+ LQRL E +E++ L+ KA+ + P+E
Sbjct: 490 PSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLE 549
Query: 602 RMQCVAAFAVSAVASQWERTG-KPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHA 660
RM VAAFA+SA AS + R G KPFNP+LGETYE +R+D GF+ SEQVSHHPPISA HA
Sbjct: 550 RMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPISACHA 609
Query: 661 EGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKL 720
E N F+F + K KFWGKS+E P GT + L + + W T C+HNI+ G+
Sbjct: 610 ESRN--FVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQR 667
Query: 721 WIEQYGNVEIIN-HKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECL 779
WIE YG + I N H C +NF + H++EG + D+S K + L+GKW E +
Sbjct: 668 WIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESI 727
Query: 780 YSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPR 839
Y ++ S +WR P
Sbjct: 728 YCGGGSS-------------------------------------------SACVWRANPM 744
Query: 840 PPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEK 899
P Q Y+FT FA+ LNE+D +S++P TD R RPD R +E G +++A +K+R+E+
Sbjct: 745 PKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQL 804
Query: 900 QRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSY 938
QR R+ ++ + + R+F + + W+ +G+Y
Sbjct: 805 QRERRRVLEENHVEHQPRFFRKSDD-----DSWVSNGTY 838
Score = 32.3 bits (72), Expect = 2.2
Identities = 28/133 (21%), Positives = 52/133 (39%), Gaps = 17/133 (12%)
Query: 250 GWRLFWVVLEHGVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKSTDSCLFFIKCFDDTIH 309
GW + L+ G+L + + Q D + GC + +V +VK + C+ D H
Sbjct: 68 GWHKRFFYLDKGILKYAKSQTD-IEREKLHGCIDVGLSVMSVKKSSKCI----DLDTEEH 122
Query: 310 GFRVPKNSLQQSREDWLEAIEEHSAYS-----------THYCSQDQLTDEEEEDTVSAAD 358
+ + S ++ ++W+ + H Y H+ S +TD S +
Sbjct: 123 IYHLKVKS-EEVFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFSGSTITDSSSGVFDSISS 181
Query: 359 LKKSLEKAQSCQQ 371
K+S Q+ Q
Sbjct: 182 RKRSSISKQNLFQ 194
>gi|14149704 oxysterol-binding protein-like protein 3 isoform a
[Homo sapiens]
Length = 887
Score = 296 bits (759), Expect = 5e-80
Identities = 181/519 (34%), Positives = 268/519 (51%), Gaps = 78/519 (15%)
Query: 430 NFKLEQEQEKNKILSEALETLA--------TEHHELEQSLVKGSPPASILSEDEFYDALS 481
N E +++N+ L L + +E + ++ L+ S + +S+D+ Y +S
Sbjct: 419 NLAEENSRDENRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSY--VS 476
Query: 482 DSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSPM 541
D SL L + + E + LG E K + RT LP+P
Sbjct: 477 DISDNLSLDNL----SNDLDNERQTLGPVLDSGREAKS------------RRRTCLPAPC 520
Query: 542 FSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVE 601
S ++ S+W+ILR IG +LSK+ MPV NEPL+ LQRL E +E++ L+ KA+ + P+E
Sbjct: 521 PSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLE 580
Query: 602 RMQCVAAFAVSAVASQWERTG-KPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHA 660
RM VAAFA+SA AS + R G KPFNP+LGETYE +R+D GF+ SEQVSHHPPISA HA
Sbjct: 581 RMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPISACHA 640
Query: 661 EGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKL 720
E N F+F + K KFWGKS+E P GT + L + + W T C+HNI+ G+
Sbjct: 641 ESRN--FVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQR 698
Query: 721 WIEQYGNVEIIN-HKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECL 779
WIE YG + I N H C +NF + H++EG + D+S K + L+GKW E +
Sbjct: 699 WIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESI 758
Query: 780 YSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPR 839
Y ++ S +WR P
Sbjct: 759 YCGGGSS-------------------------------------------SACVWRANPM 775
Query: 840 PPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEK 899
P Q Y+FT FA+ LNE+D +S++P TD R RPD R +E G +++A +K+R+E+
Sbjct: 776 PKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQL 835
Query: 900 QRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSY 938
QR R+ ++ + + R+F + + W+ +G+Y
Sbjct: 836 QRERRRVLEENHVEHQPRFFRKSDD-----DSWVSNGTY 869
Score = 32.3 bits (72), Expect = 2.2
Identities = 28/133 (21%), Positives = 52/133 (39%), Gaps = 17/133 (12%)
Query: 250 GWRLFWVVLEHGVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKSTDSCLFFIKCFDDTIH 309
GW + L+ G+L + + Q D + GC + +V +VK + C+ D H
Sbjct: 68 GWHKRFFYLDKGILKYAKSQTD-IEREKLHGCIDVGLSVMSVKKSSKCI----DLDTEEH 122
Query: 310 GFRVPKNSLQQSREDWLEAIEEHSAYS-----------THYCSQDQLTDEEEEDTVSAAD 358
+ + S ++ ++W+ + H Y H+ S +TD S +
Sbjct: 123 IYHLKVKS-EEVFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFSGSTITDSSSGVFDSISS 181
Query: 359 LKKSLEKAQSCQQ 371
K+S Q+ Q
Sbjct: 182 RKRSSISKQNLFQ 194
>gi|21735584 oxysterol-binding protein-like protein 3 isoform d
[Homo sapiens]
Length = 820
Score = 296 bits (758), Expect = 6e-80
Identities = 182/523 (34%), Positives = 271/523 (51%), Gaps = 79/523 (15%)
Query: 427 GVRN-FKLEQEQEKNKILSEALETLA--------TEHHELEQSLVKGSPPASILSEDEFY 477
G++N E +++N+ L L + +E + ++ L+ S + +S+D+ Y
Sbjct: 348 GLKNALSSENSRDENRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSY 407
Query: 478 DALSDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSL 537
+SD SL L + + E + LG E K + RT L
Sbjct: 408 --VSDISDNLSLDNL----SNDLDNERQTLGPVLDSGREAKS------------RRRTCL 449
Query: 538 PSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLS 597
P+P S ++ S+W+ILR IG +LSK+ MPV NEPL+ LQRL E +E++ L+ KA+ +
Sbjct: 450 PAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIP 509
Query: 598 DPVERMQCVAAFAVSAVASQWERTG-KPFNPLLGETYELVRDDLGFRLISEQVSHHPPIS 656
P+ERM VAAFA+SA AS + R G KPFNP+LGETYE +R+D GF+ SEQVSHHPPIS
Sbjct: 510 SPLERMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPIS 569
Query: 657 AFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNII 716
A HAE N F+F + K KFWGKS+E P GT + L + + W T C+HNI+
Sbjct: 570 ACHAESRN--FVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNIL 627
Query: 717 VGKLWIEQYGNVEIIN-HKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKW 775
G+ WIE YG + I N H C +NF + H++EG + D+S K + L+GKW
Sbjct: 628 SGQRWIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKW 687
Query: 776 TECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWR 835
E +Y ++ S +WR
Sbjct: 688 HESIYCGGGSS-------------------------------------------SACVWR 704
Query: 836 IAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKR 895
P P Q Y+FT FA+ LNE+D +S++P TD R RPD R +E G +++A +K+R
Sbjct: 705 ANPMPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQR 764
Query: 896 LEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSY 938
+E+ QR R+ ++ + + R+F + + W+ +G+Y
Sbjct: 765 IEQLQRERRRVLEENHVEHQPRFFRKSDD-----DSWVSNGTY 802
>gi|21735582 oxysterol-binding protein-like protein 3 isoform c
[Homo sapiens]
Length = 851
Score = 296 bits (758), Expect = 6e-80
Identities = 182/523 (34%), Positives = 271/523 (51%), Gaps = 79/523 (15%)
Query: 427 GVRN-FKLEQEQEKNKILSEALETLA--------TEHHELEQSLVKGSPPASILSEDEFY 477
G++N E +++N+ L L + +E + ++ L+ S + +S+D+ Y
Sbjct: 379 GLKNALSSENSRDENRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSY 438
Query: 478 DALSDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSL 537
+SD SL L + + E + LG E K + RT L
Sbjct: 439 --VSDISDNLSLDNL----SNDLDNERQTLGPVLDSGREAKS------------RRRTCL 480
Query: 538 PSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLS 597
P+P S ++ S+W+ILR IG +LSK+ MPV NEPL+ LQRL E +E++ L+ KA+ +
Sbjct: 481 PAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIP 540
Query: 598 DPVERMQCVAAFAVSAVASQWERTG-KPFNPLLGETYELVRDDLGFRLISEQVSHHPPIS 656
P+ERM VAAFA+SA AS + R G KPFNP+LGETYE +R+D GF+ SEQVSHHPPIS
Sbjct: 541 SPLERMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPIS 600
Query: 657 AFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNII 716
A HAE N F+F + K KFWGKS+E P GT + L + + W T C+HNI+
Sbjct: 601 ACHAESRN--FVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNIL 658
Query: 717 VGKLWIEQYGNVEIIN-HKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKW 775
G+ WIE YG + I N H C +NF + H++EG + D+S K + L+GKW
Sbjct: 659 SGQRWIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKW 718
Query: 776 TECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWR 835
E +Y ++ S +WR
Sbjct: 719 HESIYCGGGSS-------------------------------------------SACVWR 735
Query: 836 IAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKR 895
P P Q Y+FT FA+ LNE+D +S++P TD R RPD R +E G +++A +K+R
Sbjct: 736 ANPMPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQR 795
Query: 896 LEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSY 938
+E+ QR R+ ++ + + R+F + + W+ +G+Y
Sbjct: 796 IEQLQRERRRVLEENHVEHQPRFFRKSDD-----DSWVSNGTY 833
Score = 32.3 bits (72), Expect = 2.2
Identities = 28/133 (21%), Positives = 52/133 (39%), Gaps = 17/133 (12%)
Query: 250 GWRLFWVVLEHGVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKSTDSCLFFIKCFDDTIH 309
GW + L+ G+L + + Q D + GC + +V +VK + C+ D H
Sbjct: 68 GWHKRFFYLDKGILKYAKSQTD-IEREKLHGCIDVGLSVMSVKKSSKCI----DLDTEEH 122
Query: 310 GFRVPKNSLQQSREDWLEAIEEHSAYS-----------THYCSQDQLTDEEEEDTVSAAD 358
+ + S ++ ++W+ + H Y H+ S +TD S +
Sbjct: 123 IYHLKVKS-EEVFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFSGSTITDSSSGVFDSISS 181
Query: 359 LKKSLEKAQSCQQ 371
K+S Q+ Q
Sbjct: 182 RKRSSISKQNLFQ 194
>gi|22035612 oxysterol-binding protein-like protein 6 isoform b
[Homo sapiens]
Length = 938
Score = 295 bits (754), Expect = 2e-79
Identities = 182/493 (36%), Positives = 257/493 (52%), Gaps = 59/493 (11%)
Query: 457 LEQSLVKGSPPASILSEDEFYDA----LSDSESERSLSRLEAV---TARSFEEEGEHLGS 509
L Q + S + S EF+DA LS S SE S E+ + + E+ +
Sbjct: 480 LSQQVANESRLSMSESVSEFFDAQEVLLSASSSENEASDDESYISDVSDNISEDNTSVAD 539
Query: 510 RKHRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVI 569
R + GG A NG R LP+P ++ ++W+ILR IG +LSK++MPV
Sbjct: 540 NISRQILNGELTGG-AFRNG---RRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVE 595
Query: 570 FNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTG-KPFNPL 628
NEPL+ LQ L E ME++ L+ KAS DP ERM VAAFAVS S + R G KPFNP+
Sbjct: 596 LNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPV 655
Query: 629 LGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEP 688
LGETYE +R+D GFR SEQVSHHPPISA H E N F+F I K KFWGKS+E P
Sbjct: 656 LGETYECIREDKGFRFFSEQVSHHPPISACHCESKN--FVFWQDIRWKNKFWGKSMEILP 713
Query: 689 KGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTG-DKCVLNFKPCG 747
GT+ + L ++ + Y W T C+HNI+ G+ WIE YG V I N K+ C L F
Sbjct: 714 VGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVN 773
Query: 748 LFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQM 807
+ +++V+G + D+ K + L+GKW E LY
Sbjct: 774 YWNSNMNEVQGVVIDQEGKAVYRLFGKWHEGLY--------------------------- 806
Query: 808 STSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVI 867
+ P + +WR P N Y FT FA+ LNE+D ++ ++
Sbjct: 807 ----------------CGVAPSAKCIWRPGSMPTNYELYYGFTRFAIELNELDPVLKDLL 850
Query: 868 PKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYN 927
P TD R RPD R +E G ++ A+ EK+R+EE QR+ R+ ++ + ++F + + N
Sbjct: 851 PPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRSRRRYMEENNLEHIPKFFKKVIDA-N 909
Query: 928 GAQDWIYSGSYWD 940
+ W+ + +YW+
Sbjct: 910 QREAWVSNDTYWE 922
>gi|14210532 oxysterol-binding protein-like protein 6 isoform a
[Homo sapiens]
Length = 934
Score = 295 bits (754), Expect = 2e-79
Identities = 182/493 (36%), Positives = 257/493 (52%), Gaps = 59/493 (11%)
Query: 457 LEQSLVKGSPPASILSEDEFYDA----LSDSESERSLSRLEAV---TARSFEEEGEHLGS 509
L Q + S + S EF+DA LS S SE S E+ + + E+ +
Sbjct: 476 LSQQVANESRLSMSESVSEFFDAQEVLLSASSSENEASDDESYISDVSDNISEDNTSVAD 535
Query: 510 RKHRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVI 569
R + GG A NG R LP+P ++ ++W+ILR IG +LSK++MPV
Sbjct: 536 NISRQILNGELTGG-AFRNG---RRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVE 591
Query: 570 FNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTG-KPFNPL 628
NEPL+ LQ L E ME++ L+ KAS DP ERM VAAFAVS S + R G KPFNP+
Sbjct: 592 LNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPV 651
Query: 629 LGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEP 688
LGETYE +R+D GFR SEQVSHHPPISA H E N F+F I K KFWGKS+E P
Sbjct: 652 LGETYECIREDKGFRFFSEQVSHHPPISACHCESKN--FVFWQDIRWKNKFWGKSMEILP 709
Query: 689 KGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTG-DKCVLNFKPCG 747
GT+ + L ++ + Y W T C+HNI+ G+ WIE YG V I N K+ C L F
Sbjct: 710 VGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVN 769
Query: 748 LFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQM 807
+ +++V+G + D+ K + L+GKW E LY
Sbjct: 770 YWNSNMNEVQGVVIDQEGKAVYRLFGKWHEGLY--------------------------- 802
Query: 808 STSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVI 867
+ P + +WR P N Y FT FA+ LNE+D ++ ++
Sbjct: 803 ----------------CGVAPSAKCIWRPGSMPTNYELYYGFTRFAIELNELDPVLKDLL 846
Query: 868 PKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYN 927
P TD R RPD R +E G ++ A+ EK+R+EE QR+ R+ ++ + ++F + + N
Sbjct: 847 PPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRSRRRYMEENNLEHIPKFFKKVIDA-N 905
Query: 928 GAQDWIYSGSYWD 940
+ W+ + +YW+
Sbjct: 906 QREAWVSNDTYWE 918
>gi|22035616 oxysterol-binding protein-like protein 7 [Homo sapiens]
Length = 842
Score = 286 bits (732), Expect = 6e-77
Identities = 180/503 (35%), Positives = 255/503 (50%), Gaps = 57/503 (11%)
Query: 445 EALETLATEHHELEQSLVKGSPPASILSEDEFYDAL------SDSESERSLSRLEAVTAR 498
E E L + EL L + S + S EF+DA S SE+E S +
Sbjct: 372 EEQEALYMKGRELTPQLSQTSILSLADSHTEFFDACEVLLSASSSENEGSEEEESCTSEI 431
Query: 499 SFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIG 558
+ E L R ++ C G + R LP+ D S+W+ILR IG
Sbjct: 432 TTSLSEEMLDLRGAERCQKGGCVPGRPMG---PPRRRCLPAASGPGADVSLWNILRNNIG 488
Query: 559 MELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQW 618
+LSK++MPV NEPL+ LQRL E +E++ L+ +AS ++DP ERM +AAFAVSA +S +
Sbjct: 489 KDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSSTY 548
Query: 619 ERTG-KPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKL 677
R G KPFNP+LGETYE R D GFR ISEQVSHHPPISA HAE N F F + K
Sbjct: 549 HRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESEN--FAFWQDMKWKN 606
Query: 678 KFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGD 737
KFWGKS+E P GT+ + L + + W T C+HN++ G+ WIE YG V I N +
Sbjct: 607 KFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWIEHYGEVLIRNTQDSS 666
Query: 738 -KCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKK 796
C + F + +H+V+G + +S + L L+GKW E LY
Sbjct: 667 CHCKITFCKAKYWSSNVHEVQGAVLSRSGRVLHRLFGKWHEGLYRGP------------- 713
Query: 797 NTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVL 856
PG +W+ PP+ + + FT FA+ L
Sbjct: 714 ------------------------------TPGGQCIWKPNSMPPDHERNFGFTQFALEL 743
Query: 857 NEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKT 916
NE+ +++ +P TD RLRPD R +E G I A +K+R+E+ QR RK ++ +
Sbjct: 744 NELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQA 803
Query: 917 RWFHQGPNPYNGAQDWIYSGSYW 939
R+F + + +G + W+ + +YW
Sbjct: 804 RFFRRQTDS-SGKEWWVTNNTYW 825
>gi|22547173 oxysterol binding protein-like 9 isoform d [Homo
sapiens]
Length = 723
Score = 164 bits (414), Expect = 5e-40
Identities = 193/784 (24%), Positives = 301/784 (38%), Gaps = 167/784 (21%)
Query: 239 EGPLWKSSRFF-GWRLFWVVLEH--GVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKSTD 295
EGPL K + GW+ W VL++ G+LS+Y + D + R+GC L AV + D
Sbjct: 6 EGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSK-DKMMRGSRRGCVRLRGAVIGIDDED 64
Query: 296 SCLFFIKCFDDTIHGFRVPKNSLQQSREDWLEAIEEHSAYSTHYCS----------QD-- 343
F I T H F+ RE W+ A+EE T QD
Sbjct: 65 DSTFTITVDQKTFH-FQARD---ADEREKWIHALEETILRHTLQLQGLDSGFVPSVQDFD 120
Query: 344 -QLTDEEEEDTVSAADLKKSLEKAQSCQQRLDRE--------ISNFLKMIKECDMAKEML 394
+LT+ + + LK +K Q+C++ R+ ++ ++ IK C + ++
Sbjct: 121 KKLTEADAYLQILIEQLKLFDDKLQNCKEDEQRKKIETLKETTNSMVESIKHCIVLLQIA 180
Query: 395 PSFLQKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEH 454
S + V+ + + S V T E V+ K EQ + L TL
Sbjct: 181 KSTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRPSSLPV-GPVLATLGHHQ 239
Query: 455 HELEQSLVKG-SPPASIL--------------------SEDEFYDA----LSDSESERSL 489
S G SPP+S L SEDEFYDA S S +R +
Sbjct: 240 TPTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFSYSSSEDEFYDADEFHQSGSSPKRLI 299
Query: 490 SRLEAVTARSFEEEGEHL---------------GSRKHRMSEEKDCGGGDALSNGIKKHR 534
+ + + G L G+ + + D DA + +++H+
Sbjct: 300 DSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHK 359
Query: 535 TSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKAS 594
+ + + S +R +GM+L+K+ +P E S L+ ++ H L S
Sbjct: 360 SVI---------MHLLSQVR--LGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSIS 408
Query: 595 SLSDPVERMQCVAAFAVSA--VASQWERTGKPFNPLLGETY--------------ELVRD 638
DP +RM V + +SA + KP+NP+LGE + ELV +
Sbjct: 409 DQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSE 468
Query: 639 DL-------GFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGT 691
++EQVSHHPPISAF+AE N F+ I+ K KF G S+ G
Sbjct: 469 GPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQ 528
Query: 692 ITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGK 751
+ L+++E Y T P +I+ W+E G I KTG + F +G
Sbjct: 529 GCVSCLDYDEHYILTFPNGYGRSILTVP-WVELGGECNINCSKTGYSANIIFHTKPFYGG 587
Query: 752 ELHKVEGYI-QDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTS 810
+ H++ I KK C++ G+W +Y+ + + KK KK +++
Sbjct: 588 KKHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQ 647
Query: 811 EELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKT 870
E + S LW+
Sbjct: 648 NEYE---------------SRSLWK----------------------------------- 657
Query: 871 DCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQ 930
D IR +ID A+E K RLEE+QRA + R + E W+TR FH+ +
Sbjct: 658 DVTFNLKIR-----DIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHE------DGE 706
Query: 931 DWIY 934
W+Y
Sbjct: 707 CWVY 710
>gi|20070331 oxysterol binding protein-like 9 isoform e [Homo
sapiens]
Length = 736
Score = 156 bits (394), Expect = 1e-37
Identities = 195/797 (24%), Positives = 303/797 (38%), Gaps = 180/797 (22%)
Query: 239 EGPLWKSSRFF-GWRLFWVVLEH--GVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKSTD 295
EGPL K + GW+ W VL++ G+LS+Y + D + R+GC L AV + D
Sbjct: 6 EGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSK-DKMMRGSRRGCVRLRGAVIGIDDED 64
Query: 296 SCLFFIKCFDDTIHGFRVPKNSLQQSREDWLEAIEEHSAYSTHYCS----------QD-- 343
F I T H F+ RE W+ A+EE T QD
Sbjct: 65 DSTFTITVDQKTFH-FQARD---ADEREKWIHALEETILRHTLQLQGLDSGFVPSVQDFD 120
Query: 344 -QLTDEEEEDTVSAADLKKSLEKAQSCQQRLDRE--------ISNFLKMIKEC----DMA 390
+LT+ + + LK +K Q+C++ R+ ++ ++ IK C +A
Sbjct: 121 KKLTEADAYLQILIEQLKLFDDKLQNCKEDEQRKKIETLKETTNSMVESIKHCIVLLQIA 180
Query: 391 KEM---------LPSFLQKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNK 441
K+ + S + V+ + + S V T E V+ K EQ
Sbjct: 181 KDQSNAEKHADGMISTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRPSSLP 240
Query: 442 ILSEALETLATEHHELEQSLVKG-SPPASIL--------------------SEDEFYDA- 479
+ L TL S G SPP+S L SEDEFYDA
Sbjct: 241 V-GPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFSYSSSEDEFYDAD 299
Query: 480 ---LSDSESERSLSRLEAVTARSFEEEGEHL---------------GSRKHRMSEEKDCG 521
S S +R + + + + G L G+ + + D
Sbjct: 300 EFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDR 359
Query: 522 GGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLT 581
DA + +++H++ + + S +R +GM+L+K+ +P E S L+
Sbjct: 360 DDDAEAGSVEEHKSVI---------MHLLSQVR--LGMDLTKVVLPTFILERRSLLEMYA 408
Query: 582 EYMEHTYLIHKASSLSDPVERMQCVAAFAVSA--VASQWERTGKPFNPLLGETY------ 633
++ H L S DP +RM V + +SA + KP+NP+LGE +
Sbjct: 409 DFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIFQCHWTL 468
Query: 634 --------ELVRDDL-------GFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLK 678
ELV + ++EQVSHHPPISAF+AE N F+ I+ K K
Sbjct: 469 PNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSK 528
Query: 679 FWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDK 738
F G S+ G + L+++E Y T P +I+ W+E G I KTG
Sbjct: 529 FLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGYGRSILTVP-WVELGGECNINCSKTGYS 587
Query: 739 CVLNFKPCGLFGKELHKVEGYI-QDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKN 797
+ F +G + H++ I KK C++ G+W +Y+ + + KK
Sbjct: 588 ANIIFHTKPFYGGKKHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKL 647
Query: 798 TEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLN 857
KK +++ E + S LW+
Sbjct: 648 PIIKKKVRKLEDQNEYE---------------SRSLWK---------------------- 670
Query: 858 EVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTR 917
D IR +ID A+E K RLEE+QRA + R + E W+TR
Sbjct: 671 -------------DVTFNLKIR-----DIDAATEAKHRLEERQRAEARERKEKEIQWETR 712
Query: 918 WFHQGPNPYNGAQDWIY 934
FH+ + W+Y
Sbjct: 713 LFHE------DGECWVY 723
>gi|22547176 oxysterol binding protein-like 9 isoform f [Homo
sapiens]
Length = 746
Score = 155 bits (391), Expect = 2e-37
Identities = 193/807 (23%), Positives = 301/807 (37%), Gaps = 190/807 (23%)
Query: 239 EGPLWKSSRFF-GWRLFWVVLEH--GVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKSTD 295
EGPL K + GW+ W VL++ G+LS+Y + D + R+GC L AV + D
Sbjct: 6 EGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSK-DKMMRGSRRGCVRLRGAVIGIDDED 64
Query: 296 SCLFFIKCFDDTIHGFRVPKNSLQQSREDWLEAIEEHSAYSTHYCS-------------- 341
F I T H F+ RE W+ A+EE T
Sbjct: 65 DSTFTITVDQKTFH-FQARD---ADEREKWIHALEETILRHTLQLQISTTLAFFQSSGIS 120
Query: 342 -------------------QD---QLTDEEEEDTVSAADLKKSLEKAQSCQQRLDRE--- 376
QD +LT+ + + LK +K Q+C++ R+
Sbjct: 121 PVLEFSKIIGLDSGFVPSVQDFDKKLTEADAYLQILIEQLKLFDDKLQNCKEDEQRKKIE 180
Query: 377 -----ISNFLKMIKECDMAKEMLPSFLQKVEVVSEASRETCVALTDCLNLFTKQEGVRNF 431
++ ++ IK C + ++ S + V+ + + S V T E V+
Sbjct: 181 TLKETTNSMVESIKHCIVLLQIAKSTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLC 240
Query: 432 KLEQEQEKNKILSEALETLATEHHELEQSLVKG-SPPASIL------------------- 471
K EQ + L TL S G SPP+S L
Sbjct: 241 KSEQRPSSLPV-GPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFSYS 299
Query: 472 -SEDEFYDA----LSDSESERSLSRLEAVTARSFEEEGEHL---------------GSRK 511
SEDEFYDA S S +R + + + + G L G+
Sbjct: 300 SSEDEFYDADEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSD 359
Query: 512 HRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFN 571
+ + D DA + +++H++ + + S +R +GM+L+K+ +P
Sbjct: 360 ADLFDSHDDRDDDAEAGSVEEHKSVI---------MHLLSQVR--LGMDLTKVVLPTFIL 408
Query: 572 EPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSA--VASQWERTGKPFNPLL 629
E S L+ ++ H L S DP +RM V + +SA + KP+NP+L
Sbjct: 409 ERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPIL 468
Query: 630 GETY--------------ELVRDDL-------GFRLISEQVSHHPPISAFHAEGLNNDFI 668
GE + ELV + ++EQVSHHPPISAF+AE N
Sbjct: 469 GEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQ 528
Query: 669 FHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNV 728
F+ I+ K KF G S+ G + L+++E Y T P +I+ W+E G
Sbjct: 529 FNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGYGRSILTVP-WVELGGEC 587
Query: 729 EIINHKTGDKCVLNFKPCGLFGKELHKVEGYI-QDKSKKKLCALYGKWTECLYSVDPATF 787
I KTG + F +G + H++ I KK C++ G+W +Y+
Sbjct: 588 NINCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATGE 647
Query: 788 DAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMY 847
+ + KK KK +++ E + S LW+
Sbjct: 648 NTVFVDTKKLPIIKKKVRKLEDQNEYE---------------SRSLWK------------ 680
Query: 848 NFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNR 907
D IR +ID A+E K RLEE+QRA + R
Sbjct: 681 -----------------------DVTFNLKIR-----DIDAATEAKHRLEERQRAEARER 712
Query: 908 SKSEEDWKTRWFHQGPNPYNGAQDWIY 934
+ E W+TR FH+ + W+Y
Sbjct: 713 KEKEIQWETRLFHE------DGECWVY 733
>gi|51243032 oxysterol-binding protein-like protein 8 isoform b
[Homo sapiens]
Length = 847
Score = 142 bits (359), Expect = 1e-33
Identities = 112/386 (29%), Positives = 171/386 (44%), Gaps = 59/386 (15%)
Query: 545 NDFSIWSILRKCI-GMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERM 603
N IW++L++ GM+LSK+ +P EP SFL +L++Y H + +A+ +P R+
Sbjct: 361 NKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRL 420
Query: 604 QCVAAFAVSAVASQWERTGKPFNPLLGETYELV----RDDLGFRLISEQVSHHPPISAFH 659
+ V + +S + + KP+NP+LGET+ + R + I+EQVSHHPPISAF+
Sbjct: 421 KKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFY 480
Query: 660 AEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGK 719
+ F GSI K KF+G S+ A +G L L E Y T P I+ G
Sbjct: 481 VSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGT 540
Query: 720 LWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKE--LHKVEGYIQDKSKKKLCALYGKWTE 777
+ +E G V I KTG +L FK G ++++ G ++ K+ L L G W
Sbjct: 541 MTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVNQISGKLK-LGKEVLATLEGHW-- 597
Query: 778 CLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIA 837
D F KK D + E+ P PD + WR+
Sbjct: 598 -----DSEVFITDKKTD---------------NSEVFWNPTPD----------IKQWRLI 627
Query: 838 PRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLE 897
+ +F E +K + V RA+ + +A++EK LE
Sbjct: 628 RHTVKFEEQGDF--------ESEKLWQRV-----------TRAINAKDQTEATQEKYVLE 668
Query: 898 EKQRAARKNRSKSEEDWKTRWFHQGP 923
E QR A ++R E+W + F P
Sbjct: 669 EAQRQAARDRKTKNEEWSCKLFELDP 694
>gi|18079218 oxysterol-binding protein-like protein 8 isoform a
[Homo sapiens]
Length = 889
Score = 142 bits (359), Expect = 1e-33
Identities = 112/386 (29%), Positives = 171/386 (44%), Gaps = 59/386 (15%)
Query: 545 NDFSIWSILRKCI-GMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERM 603
N IW++L++ GM+LSK+ +P EP SFL +L++Y H + +A+ +P R+
Sbjct: 403 NKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRL 462
Query: 604 QCVAAFAVSAVASQWERTGKPFNPLLGETYELV----RDDLGFRLISEQVSHHPPISAFH 659
+ V + +S + + KP+NP+LGET+ + R + I+EQVSHHPPISAF+
Sbjct: 463 KKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFY 522
Query: 660 AEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGK 719
+ F GSI K KF+G S+ A +G L L E Y T P I+ G
Sbjct: 523 VSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGT 582
Query: 720 LWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKE--LHKVEGYIQDKSKKKLCALYGKWTE 777
+ +E G V I KTG +L FK G ++++ G ++ K+ L L G W
Sbjct: 583 MTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVNQISGKLK-LGKEVLATLEGHW-- 639
Query: 778 CLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIA 837
D F KK D + E+ P PD + WR+
Sbjct: 640 -----DSEVFITDKKTD---------------NSEVFWNPTPD----------IKQWRLI 669
Query: 838 PRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLE 897
+ +F E +K + V RA+ + +A++EK LE
Sbjct: 670 RHTVKFEEQGDF--------ESEKLWQRV-----------TRAINAKDQTEATQEKYVLE 710
Query: 898 EKQRAARKNRSKSEEDWKTRWFHQGP 923
E QR A ++R E+W + F P
Sbjct: 711 EAQRQAARDRKTKNEEWSCKLFELDP 736
>gi|14149740 oxysterol-binding protein-like protein 5 isoform a
[Homo sapiens]
Length = 879
Score = 139 bits (349), Expect = 2e-32
Identities = 117/407 (28%), Positives = 175/407 (42%), Gaps = 68/407 (16%)
Query: 545 NDFSIWSILRKCI-GMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERM 603
N +W++L++ GM+LS++ +P EP SFL +L++Y H L+ +A+ D RM
Sbjct: 367 NKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRM 426
Query: 604 QCVAAFAVSAVASQWERTGKPFNPLLGETYELV----RDDLGFRLISEQVSHHPPISAFH 659
+ V + +S + + KP+NP+LGET+ + D I+EQVSHHPP+SAFH
Sbjct: 427 KLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFH 486
Query: 660 AEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGK 719
+ F GSI K +F+G S+ A G TL L E YT T P I+ G
Sbjct: 487 VSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGT 546
Query: 720 LWIEQYGNVEIINHKTGDKCVLNFKPCGLFG--KELHKVEGYIQDKSKKKLCALYGKWTE 777
+ +E G V I K + L FK FG ++++ G I ++ L +L G W
Sbjct: 547 MTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKI-TSGEEVLASLSGHWDR 605
Query: 778 CLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIA 837
D + K + + S L W
Sbjct: 606 ----------DVFIKEEGSGS-------------------------------SALFW--- 621
Query: 838 PRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDI-RAMENGEIDQASEEKKRL 896
P + + L E ++ES RL + RA+ G+ +A++EK L
Sbjct: 622 -TPSGEVRRQRLRQHTVPLEE-QTELESE------RLWQHVTRAISKGDQHRATQEKFAL 673
Query: 897 EEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIY---SGSYWD 940
EE QR + R +S WK + FH P Q+W Y S WD
Sbjct: 674 EEAQRQRARERQESLMPWKPQLFHLDPI----TQEWHYRYEDHSPWD 716
>gi|221136766 oxysterol-binding protein-like protein 5 isoform b
[Homo sapiens]
Length = 811
Score = 139 bits (349), Expect = 2e-32
Identities = 117/407 (28%), Positives = 175/407 (42%), Gaps = 68/407 (16%)
Query: 545 NDFSIWSILRKCI-GMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERM 603
N +W++L++ GM+LS++ +P EP SFL +L++Y H L+ +A+ D RM
Sbjct: 299 NKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRM 358
Query: 604 QCVAAFAVSAVASQWERTGKPFNPLLGETYELV----RDDLGFRLISEQVSHHPPISAFH 659
+ V + +S + + KP+NP+LGET+ + D I+EQVSHHPP+SAFH
Sbjct: 359 KLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFH 418
Query: 660 AEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGK 719
+ F GSI K +F+G S+ A G TL L E YT T P I+ G
Sbjct: 419 VSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGT 478
Query: 720 LWIEQYGNVEIINHKTGDKCVLNFKPCGLFG--KELHKVEGYIQDKSKKKLCALYGKWTE 777
+ +E G V I K + L FK FG ++++ G I ++ L +L G W
Sbjct: 479 MTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKI-TSGEEVLASLSGHWDR 537
Query: 778 CLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIA 837
D + K + + S L W
Sbjct: 538 ----------DVFIKEEGSGS-------------------------------SALFW--- 553
Query: 838 PRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDI-RAMENGEIDQASEEKKRL 896
P + + L E ++ES RL + RA+ G+ +A++EK L
Sbjct: 554 -TPSGEVRRQRLRQHTVPLEE-QTELESE------RLWQHVTRAISKGDQHRATQEKFAL 605
Query: 897 EEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIY---SGSYWD 940
EE QR + R +S WK + FH P Q+W Y S WD
Sbjct: 606 EEAQRQRARERQESLMPWKPQLFHLDPI----TQEWHYRYEDHSPWD 648
>gi|22035609 oxysterol-binding protein-like protein 5 isoform b
[Homo sapiens]
Length = 811
Score = 139 bits (349), Expect = 2e-32
Identities = 117/407 (28%), Positives = 175/407 (42%), Gaps = 68/407 (16%)
Query: 545 NDFSIWSILRKCI-GMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERM 603
N +W++L++ GM+LS++ +P EP SFL +L++Y H L+ +A+ D RM
Sbjct: 299 NKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRM 358
Query: 604 QCVAAFAVSAVASQWERTGKPFNPLLGETYELV----RDDLGFRLISEQVSHHPPISAFH 659
+ V + +S + + KP+NP+LGET+ + D I+EQVSHHPP+SAFH
Sbjct: 359 KLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFH 418
Query: 660 AEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGK 719
+ F GSI K +F+G S+ A G TL L E YT T P I+ G
Sbjct: 419 VSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGT 478
Query: 720 LWIEQYGNVEIINHKTGDKCVLNFKPCGLFG--KELHKVEGYIQDKSKKKLCALYGKWTE 777
+ +E G V I K + L FK FG ++++ G I ++ L +L G W
Sbjct: 479 MTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKI-TSGEEVLASLSGHWDR 537
Query: 778 CLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIA 837
D + K + + S L W
Sbjct: 538 ----------DVFIKEEGSGS-------------------------------SALFW--- 553
Query: 838 PRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDI-RAMENGEIDQASEEKKRL 896
P + + L E ++ES RL + RA+ G+ +A++EK L
Sbjct: 554 -TPSGEVRRQRLRQHTVPLEE-QTELESE------RLWQHVTRAISKGDQHRATQEKFAL 605
Query: 897 EEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIY---SGSYWD 940
EE QR + R +S WK + FH P Q+W Y S WD
Sbjct: 606 EEAQRQRARERQESLMPWKPQLFHLDPI----TQEWHYRYEDHSPWD 648
>gi|22547171 oxysterol binding protein-like 9 isoform c [Homo
sapiens]
Length = 626
Score = 137 bits (344), Expect = 6e-32
Identities = 157/663 (23%), Positives = 252/663 (38%), Gaps = 146/663 (22%)
Query: 344 QLTDEEEEDTVSAADLKKSLEKAQSCQQRLDRE--------ISNFLKMIKECDMAKEMLP 395
+LT+ + + LK +K Q+C++ R+ ++ ++ IK C + ++
Sbjct: 25 KLTEADAYLQILIEQLKLFDDKLQNCKEDEQRKKIETLKETTNSMVESIKHCIVLLQIAK 84
Query: 396 SFLQKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHH 455
S + V+ + + S V T E V+ K EQ + L TL
Sbjct: 85 STINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRPSSLPV-GPVLATLGHHQT 143
Query: 456 ELEQSLVKG-SPPASIL--------------------SEDEFYDA----LSDSESERSLS 490
S G SPP+S L SEDEFYDA S S +R +
Sbjct: 144 PTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFSYSSSEDEFYDADEFHQSGSSPKRLID 203
Query: 491 RLEAVTARSFEEEGEHL---------------GSRKHRMSEEKDCGGGDALSNGIKKHRT 535
+ + + G L G+ + + D DA + +++H++
Sbjct: 204 SSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKS 263
Query: 536 SLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASS 595
+ + S +R +GM+L+K+ +P E S L+ ++ H L S
Sbjct: 264 VI---------MHLLSQVR--LGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISD 312
Query: 596 LSDPVERMQCVAAFAVSA--VASQWERTGKPFNPLLGETY--------------ELVRDD 639
DP +RM V + +SA + KP+NP+LGE + ELV +
Sbjct: 313 QKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEG 372
Query: 640 L-------GFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTI 692
++EQVSHHPPISAF+AE N F+ I+ K KF G S+ G
Sbjct: 373 PVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQG 432
Query: 693 TLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKE 752
+ L+++E Y T P +I+ W+E G I KTG + F +G +
Sbjct: 433 CVSCLDYDEHYILTFPNGYGRSILTVP-WVELGGECNINCSKTGYSANIIFHTKPFYGGK 491
Query: 753 LHKVEGYI-QDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSE 811
H++ I KK C++ G+W +Y+ + + KK KK +++
Sbjct: 492 KHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQN 551
Query: 812 ELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTD 871
E + S LW+ D
Sbjct: 552 EYE---------------SRSLWK-----------------------------------D 561
Query: 872 CRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQD 931
IR +ID A+E K RLEE+QRA + R + E W+TR FH+ +
Sbjct: 562 VTFNLKIR-----DIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHE------DGEC 610
Query: 932 WIY 934
W+Y
Sbjct: 611 WVY 613
>gi|22547167 oxysterol binding protein-like 9 isoform a [Homo
sapiens]
Length = 558
Score = 132 bits (332), Expect = 2e-30
Identities = 149/618 (24%), Positives = 233/618 (37%), Gaps = 138/618 (22%)
Query: 381 LKMIKECDMAKEMLPSFLQKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKN 440
++ IK C + ++ S + V+ + + S V T E V+ K EQ
Sbjct: 2 VESIKHCIVLLQIAKSTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRPSSL 61
Query: 441 KILSEALETLATEHHELEQSLVKG-SPPASIL--------------------SEDEFYDA 479
+ L TL S G SPP+S L SEDEFYDA
Sbjct: 62 PV-GPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFSYSSSEDEFYDA 120
Query: 480 ----LSDSESERSLSRLEAVTARSFEEEGEHL---------------GSRKHRMSEEKDC 520
S S +R + + + + G L G+ + + D
Sbjct: 121 DEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDD 180
Query: 521 GGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRL 580
DA + +++H++ + + S +R +GM+L+K+ +P E S L+
Sbjct: 181 RDDDAEAGSVEEHKSVI---------MHLLSQVR--LGMDLTKVVLPTFILERRSLLEMY 229
Query: 581 TEYMEHTYLIHKASSLSDPVERMQCVAAFAVSA--VASQWERTGKPFNPLLGETY----- 633
++ H L S DP +RM V + +SA + KP+NP+LGE +
Sbjct: 230 ADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIFQCHWT 289
Query: 634 ---------ELVRDDL-------GFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKL 677
ELV + ++EQVSHHPPISAF+AE N F+ I+ K
Sbjct: 290 LPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKS 349
Query: 678 KFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGD 737
KF G S+ G + L+++E Y T P +I+ W+E G I KTG
Sbjct: 350 KFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGYGRSILTVP-WVELGGECNINCSKTGY 408
Query: 738 KCVLNFKPCGLFGKELHKVEGYI-QDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKK 796
+ F +G + H++ I KK C++ G+W +Y+ + + KK
Sbjct: 409 SANIIFHTKPFYGGKKHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKK 468
Query: 797 NTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVL 856
KK +++ E + S LW+
Sbjct: 469 LPIIKKKVRKLEDQNEYE---------------SRSLWK--------------------- 492
Query: 857 NEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKT 916
D IR +ID A+E K RLEE+QRA + R + E W+T
Sbjct: 493 --------------DVTFNLKIR-----DIDAATEAKHRLEERQRAEARERKEKEIQWET 533
Query: 917 RWFHQGPNPYNGAQDWIY 934
R FH+ + W+Y
Sbjct: 534 RLFHE------DGECWVY 545
>gi|22547165 oxysterol binding protein-like 9 isoform a [Homo
sapiens]
Length = 558
Score = 132 bits (332), Expect = 2e-30
Identities = 149/618 (24%), Positives = 233/618 (37%), Gaps = 138/618 (22%)
Query: 381 LKMIKECDMAKEMLPSFLQKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKN 440
++ IK C + ++ S + V+ + + S V T E V+ K EQ
Sbjct: 2 VESIKHCIVLLQIAKSTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRPSSL 61
Query: 441 KILSEALETLATEHHELEQSLVKG-SPPASIL--------------------SEDEFYDA 479
+ L TL S G SPP+S L SEDEFYDA
Sbjct: 62 PV-GPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFSYSSSEDEFYDA 120
Query: 480 ----LSDSESERSLSRLEAVTARSFEEEGEHL---------------GSRKHRMSEEKDC 520
S S +R + + + + G L G+ + + D
Sbjct: 121 DEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDD 180
Query: 521 GGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRL 580
DA + +++H++ + + S +R +GM+L+K+ +P E S L+
Sbjct: 181 RDDDAEAGSVEEHKSVI---------MHLLSQVR--LGMDLTKVVLPTFILERRSLLEMY 229
Query: 581 TEYMEHTYLIHKASSLSDPVERMQCVAAFAVSA--VASQWERTGKPFNPLLGETY----- 633
++ H L S DP +RM V + +SA + KP+NP+LGE +
Sbjct: 230 ADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIFQCHWT 289
Query: 634 ---------ELVRDDL-------GFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKL 677
ELV + ++EQVSHHPPISAF+AE N F+ I+ K
Sbjct: 290 LPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKS 349
Query: 678 KFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGD 737
KF G S+ G + L+++E Y T P +I+ W+E G I KTG
Sbjct: 350 KFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGYGRSILTVP-WVELGGECNINCSKTGY 408
Query: 738 KCVLNFKPCGLFGKELHKVEGYI-QDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKK 796
+ F +G + H++ I KK C++ G+W +Y+ + + KK
Sbjct: 409 SANIIFHTKPFYGGKKHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKK 468
Query: 797 NTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVL 856
KK +++ E + S LW+
Sbjct: 469 LPIIKKKVRKLEDQNEYE---------------SRSLWK--------------------- 492
Query: 857 NEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKT 916
D IR +ID A+E K RLEE+QRA + R + E W+T
Sbjct: 493 --------------DVTFNLKIR-----DIDAATEAKHRLEERQRAEARERKEKEIQWET 533
Query: 917 RWFHQGPNPYNGAQDWIY 934
R FH+ + W+Y
Sbjct: 534 RLFHE------DGECWVY 545
>gi|22547169 oxysterol binding protein-like 9 isoform b [Homo
sapiens]
Length = 571
Score = 130 bits (327), Expect = 6e-30
Identities = 125/506 (24%), Positives = 201/506 (39%), Gaps = 100/506 (19%)
Query: 453 EHHELEQSLVKGSPPASILSEDEFYDALSDSESERSLSRLEAVTARSFEEEGEHLGSRKH 512
E ++ ++ GS P ++ L+ S S SL R + T S + G+
Sbjct: 129 EFYDADEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPD--TTESLNSSLSN-GTSDA 185
Query: 513 RMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNE 572
+ + D DA + +++H++ + + S +R +GM+L+K+ +P E
Sbjct: 186 DLFDSHDDRDDDAEAGSVEEHKSVI---------MHLLSQVR--LGMDLTKVVLPTFILE 234
Query: 573 PLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSA--VASQWERTGKPFNPLLG 630
S L+ ++ H L S DP +RM V + +SA + KP+NP+LG
Sbjct: 235 RRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILG 294
Query: 631 ETY--------------ELVRDDL-------GFRLISEQVSHHPPISAFHAEGLNNDFIF 669
E + ELV + ++EQVSHHPPISAF+AE N F
Sbjct: 295 EIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQF 354
Query: 670 HGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVE 729
+ I+ K KF G S+ G + L+++E Y T P +I+ W+E G
Sbjct: 355 NAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGYGRSILTVP-WVELGGECN 413
Query: 730 IINHKTGDKCVLNFKPCGLFGKELHKVEGYI-QDKSKKKLCALYGKWTECLYSVDPATFD 788
I KTG + F +G + H++ I KK C++ G+W +Y+ +
Sbjct: 414 INCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATGEN 473
Query: 789 AYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYN 848
+ KK KK +++ E + S LW+
Sbjct: 474 TVFVDTKKLPIIKKKVRKLEDQNEYE---------------SRSLWK------------- 505
Query: 849 FTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRS 908
D IR +ID A+E K RLEE+QRA + R
Sbjct: 506 ----------------------DVTFNLKIR-----DIDAATEAKHRLEERQRAEARERK 538
Query: 909 KSEEDWKTRWFHQGPNPYNGAQDWIY 934
+ E W+TR FH+ + W+Y
Sbjct: 539 EKEIQWETRLFHE------DGECWVY 558
>gi|19923592 oxysterol binding protein-like 11 [Homo sapiens]
Length = 747
Score = 110 bits (276), Expect = 5e-24
Identities = 96/422 (22%), Positives = 161/422 (38%), Gaps = 102/422 (24%)
Query: 557 IGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAV-- 614
+GM+L+++ +P E S L+ ++M H L ++ + +RM + +++
Sbjct: 379 LGMDLTRVVLPTFILEKRSLLEMYADFMSHPDLFIAITNGATAEDRMIRFVEYYLTSFHE 438
Query: 615 ASQWERTGKPFNPLLGETY------------------------------------ELVRD 638
+ KP+NP++GET+ ++ D
Sbjct: 439 GRKGAIAKKPYNPIIGETFHCSWKMPKSEVASSVFSSSSTQGVTNHAPLSGESLTQVGSD 498
Query: 639 DLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLE 698
R ++EQVSHHPP+S F+AE + ++ K KF G S+ G L LLE
Sbjct: 499 CYTVRFVAEQVSHHPPVSGFYAECTERKMCVNAHVWTKSKFLGMSIGVTMVGEGILSLLE 558
Query: 699 HNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEG 758
H E YT++ P C I+ W+E G V + KTG + F +G +LH+V
Sbjct: 559 HGEEYTFSLP-CAYARSILTVPWVELGGKVSVNCAKTGYSASITFHTKPFYGGKLHRVTA 617
Query: 759 YIQDK-SKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMP 817
++ + +C + G+W L Y + K + K + L++
Sbjct: 618 EVKHNITNTVVCRVQGEWNSVLEF-------TYSNGETKYVDLTKLAVTKKRVRPLEKQD 670
Query: 818 VPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPD 877
+S LW+ N D ES
Sbjct: 671 PFESRR---------LWK---------------------NVTDSLRES------------ 688
Query: 878 IRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGS 937
EID+A+E K LEE+QR ++R+++ WKT++F W+Y
Sbjct: 689 -------EIDKATEHKHTLEERQRTEERHRTETGTPWKTKYF------IKEGDGWVYHKP 735
Query: 938 YW 939
W
Sbjct: 736 LW 737
>gi|19923812 oxysterol-binding protein-like protein 10 [Homo
sapiens]
Length = 764
Score = 108 bits (270), Expect = 2e-23
Identities = 112/453 (24%), Positives = 187/453 (41%), Gaps = 73/453 (16%)
Query: 399 QKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELE 458
Q + ++ S T L +CLNL Q+ V + Q +K L ++ H E
Sbjct: 273 QDLLLLKATSAATLSCLGECLNLL--QQSVH--QAGQPSQKPGASENILGWHGSKSHSTE 328
Query: 459 Q--SLVKGSPPASILSEDEFYDALSDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSE 516
Q + GS P++ S + + L +S + S+ E G L + S+
Sbjct: 329 QLKNGTLGSLPSA--SANITWAILPNSAEDEQTSQPEPEP-----NSGSELVLSEDEKSD 381
Query: 517 EKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSF 576
+D K T L M + + I + +GM+L+K+ +P E S
Sbjct: 382 NED------------KEETEL-GVMEDQRSIILHLISQLKLGMDLTKVVLPTFILEKRSL 428
Query: 577 LQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAV--ASQWERTGKPFNPLLGETY- 633
L+ ++M H L+ ++ + P ER+ C + ++A + KP+NP++GET+
Sbjct: 429 LEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHEGRKGALAKKPYNPIIGETFH 488
Query: 634 ---ELVRDDLG--------------------------FRLISEQVSHHPPISAFHAEGLN 664
E+ +D + R ++EQVSHHPPIS F+ E
Sbjct: 489 CSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLRFVAEQVSHHPPISCFYCECEE 548
Query: 665 NDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQ 724
+ ++ K KF G SV G L LLEH E Y +T P+ +I+ W+E
Sbjct: 549 KRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSILTIP-WVEL 607
Query: 725 YGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQ-DKSKKKLCALYGKWT---ECLY 780
G V I KTG + F +G ++H+V ++ + + +C +G+W E Y
Sbjct: 608 GGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTY 667
Query: 781 S------VDPATFDAYKKN----DKKNTEEKKN 803
+ +D T Y K +K+ E +N
Sbjct: 668 NNGETKVIDTTTLPVYPKKIRPLEKQGPMESRN 700
Score = 44.7 bits (104), Expect = 4e-04
Identities = 21/61 (34%), Positives = 30/61 (49%), Gaps = 6/61 (9%)
Query: 879 RAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSY 938
R + G+ID A+E+K+ LEEKQR + R WK ++F Q W+Y
Sbjct: 707 RYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQ------EGDGWVYFNPL 760
Query: 939 W 939
W
Sbjct: 761 W 761
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 100 bits (248), Expect = 8e-21
Identities = 77/235 (32%), Positives = 118/235 (50%), Gaps = 36/235 (15%)
Query: 5 AEQQLLHHARNGNAEEVRQLLET---------------------MARNEVIADINCKG-- 41
A ++L RNG+ E V++L+ R +V+ + G
Sbjct: 24 AARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGAN 83
Query: 42 -RSKSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLL 100
+++ + G PLH AC FGH +VV LL+ GA+ N ++ TPLH AA G+ ++ ++L
Sbjct: 84 VQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVL 143
Query: 101 LEYNADTTIVNGSGQTAKEVTHAEEIRSMLEAVERTQQRKLEELLLAAAREGKTTELTAL 160
L++ A+ TI N G+TA ++ +AV + +K E LL +AR G ++ AL
Sbjct: 144 LQHGAEPTIRNTDGRTALDLADPS-----AKAVLTGEYKKDE--LLESARSGNEEKMMAL 196
Query: 161 LNRPNPPDVNC--SDQLGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPL 213
L P +VNC SD +TPLH AA + LL+ GAD + K+K D PL
Sbjct: 197 L---TPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPL 248
Score = 97.8 bits (242), Expect = 4e-20
Identities = 86/292 (29%), Positives = 135/292 (46%), Gaps = 44/292 (15%)
Query: 2 NTEAEQQLLHHARNGNAEEVRQLLETMARN------------------------EVIADI 37
N+EA++QLL A+ G+ E V++L + N E +
Sbjct: 489 NSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH 548
Query: 38 NCKGRSKSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELV 97
+K G PLH AC +GH +V + L+K GA VNV + TPLH AA G+ E+
Sbjct: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEIC 608
Query: 98 MLLLEYNADTTIVNGSGQTAKEVTH--AEEIRSMLEAVERTQQRKLEELLLAAAREGKTT 155
LLL++ AD T N G T ++ +I+ +L + LL AA++G
Sbjct: 609 KLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRG---------DAALLDAAKKGCLA 659
Query: 156 ELTALLNRPNPPDVNCSDQLG--NTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPL 213
+ L +P +VNC D G +TPLH AA + + A LL+ GAD N ++K PL
Sbjct: 660 RVKKL---SSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPL 716
Query: 214 DLAQG---AEMKHILVGNKVIYKALKRYE-GPLWKSSRFFGWRLFWVVLEHG 261
A ++ +L+ A ++ PL ++++ +L ++L HG
Sbjct: 717 HNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHG 768
Score = 88.2 bits (217), Expect = 3e-17
Identities = 77/264 (29%), Positives = 126/264 (47%), Gaps = 16/264 (6%)
Query: 4 EAEQQLLHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQV 63
+ + LH A + +Q+ E + R A+IN K+ TPLH+A H V
Sbjct: 362 QTHETALHCAAASPYPKRKQICELLLRKG--ANIN----EKTKEFLTPLHVASEKAHNDV 415
Query: 64 VQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVTHA 123
V+ ++K A+VN L+++G T LHRAA+ G + LLL Y D I++ G TA ++ +
Sbjct: 416 VEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGN- 474
Query: 124 EEIRSMLEAVERTQQRKLEELLLAAAREGKTTELTALLNRPNPPDVNCSDQLG--NTPLH 181
E ++ +L+ + + LL AA+ G + L VNC D G +TPLH
Sbjct: 475 ENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLC---TVQSVNCRDIEGRQSTPLH 531
Query: 182 CAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQG---AEMKHILVGNKVIYKALKRY 238
AA LL+ GAD + K+K PL A E+ +LV + + +
Sbjct: 532 FAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLW 591
Query: 239 E-GPLWKSSRFFGWRLFWVVLEHG 261
+ PL +++ + + ++L+HG
Sbjct: 592 KFTPLHEAAAKGKYEICKLLLQHG 615
Score = 87.0 bits (214), Expect = 7e-17
Identities = 75/215 (34%), Positives = 102/215 (47%), Gaps = 30/215 (13%)
Query: 10 LHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLLK 69
LH A N ++ QLL AD++ K K +L PLH AC +GH +V + L+K
Sbjct: 215 LHLAAGYNRVKIVQLLLQHG-----ADVHAK--DKGDL--VPLHNACSYGHYEVTELLVK 265
Query: 70 AGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVTHAEEIRSM 129
GA VN ++ TPLH AA R E+ LLL Y AD T++N ++A ++ +++
Sbjct: 266 HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLK-- 323
Query: 130 LEAVERTQQRKLEELLLAAAREGKTTEL-----TALLNRPNPPDVNCSDQLGNTPLHCAA 184
ER LL AARE T + ++N +P Q T LHCAA
Sbjct: 324 ----ERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHP-------QTHETALHCAA 372
Query: 185 ---YRAHKQCALKLLRSGADPNLKNKNDQKPLDLA 216
Y KQ LLR GA+ N K K PL +A
Sbjct: 373 ASPYPKRKQICELLLRKGANINEKTKEFLTPLHVA 407
Score = 67.4 bits (163), Expect = 6e-11
Identities = 45/123 (36%), Positives = 62/123 (50%), Gaps = 9/123 (7%)
Query: 10 LHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLLK 69
LH A N EV + L AD+N + + G PLH A +GH V L+K
Sbjct: 683 LHLAAGYNNLEVAEYLLQHG-----ADVNAQDKG----GLIPLHNAASYGHVDVAALLIK 733
Query: 70 AGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVTHAEEIRSM 129
A VN + TPLH AA GR +L LLL + AD T+ N GQT ++ A+++ ++
Sbjct: 734 YNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSAL 793
Query: 130 LEA 132
L A
Sbjct: 794 LTA 796
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 96.7 bits (239), Expect = 9e-20
Identities = 82/222 (36%), Positives = 104/222 (46%), Gaps = 32/222 (14%)
Query: 10 LHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLLK 69
LH A N + QLL AD++ K + G PLH AC +GH +V + LLK
Sbjct: 373 LHLAAGYNRVRIVQLLLQHG-----ADVHAKDKG----GLVPLHNACSYGHYEVTELLLK 423
Query: 70 AGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVTHAEEIRSM 129
GA VN ++ TPLH AA R E+ LLL + AD T+VN G++A ++ E+R
Sbjct: 424 HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELR-- 481
Query: 130 LEAVERTQQRKLEELLLAAAREG-----KTTELTALLNRPNPPDVNCSDQLGNTPLHCAA 184
ER LL AARE K T ++N P Q T LHCA
Sbjct: 482 ----ERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQP-------QSHETALHCAV 530
Query: 185 YRAH---KQCALKLLRSGADPNLKNKNDQKPLDLAQGAEMKH 223
H KQ LLR GA+ N KNK+ PL +A AE H
Sbjct: 531 ASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVA--AERAH 570
Score = 96.3 bits (238), Expect = 1e-19
Identities = 77/235 (32%), Positives = 115/235 (48%), Gaps = 36/235 (15%)
Query: 5 AEQQLLHHARNGNAEEVRQLLET---------------------MARNEVIADINCKG-- 41
A ++LL RNG+ V++L++ R +V+ + G
Sbjct: 182 ALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGAN 241
Query: 42 -RSKSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLL 100
++ + G PLH AC FGH +VV LL GA+ N ++ TPLH AA G+ ++ ++L
Sbjct: 242 VHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
Query: 101 LEYNADTTIVNGSGQTAKEVTHAEEIRSMLEAVERTQQRKLEELLLAAAREGKTTELTAL 160
L++ AD I N G++A ++ +AV + +K E LL AAR G +L AL
Sbjct: 302 LQHGADPNIRNTDGKSALDLADPS-----AKAVLTGEYKKDE--LLEAARSGNEEKLMAL 354
Query: 161 LNRPNPPDVNC--SDQLGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPL 213
L P +VNC SD +TPLH AA + LL+ GAD + K+K PL
Sbjct: 355 L---TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPL 406
Score = 89.4 bits (220), Expect = 1e-17
Identities = 73/235 (31%), Positives = 115/235 (48%), Gaps = 24/235 (10%)
Query: 35 ADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRK 94
AD++ K + G PLH AC +GH +V + L++ GA VNV + TPLH AA G+
Sbjct: 708 ADVHAKDKG----GLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKY 763
Query: 95 ELVMLLLEYNADTTIVNGSGQTAKEVTHA--EEIRSMLEAVERTQQRKLEELLLAAAREG 152
E+ LLL++ AD T N G T ++ +I+ +L + LL AA++G
Sbjct: 764 EICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRG---------DAALLDAAKKG 814
Query: 153 KTTELTALLNRPNPPDVNCSDQLG--NTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQ 210
+ L P ++NC D G +TPLH AA + + A LL GAD N ++K
Sbjct: 815 CLARVQKLC---TPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGL 871
Query: 211 KPLDLAQG---AEMKHILVGNKVIYKALKRYE-GPLWKSSRFFGWRLFWVVLEHG 261
PL A ++ +L+ A ++ PL ++++ +L ++L HG
Sbjct: 872 IPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHG 926
Score = 87.4 bits (215), Expect = 6e-17
Identities = 73/243 (30%), Positives = 113/243 (46%), Gaps = 14/243 (5%)
Query: 4 EAEQQLLHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQV 63
++ + LH A + +Q+ E + R A++N K + TPLH+A H V
Sbjct: 520 QSHETALHCAVASLHPKRKQVTELLLRKG--ANVNEKNKDFM----TPLHVAAERAHNDV 573
Query: 64 VQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVTHA 123
++ L K GA++N L+ +G T LHRAA G + LLL Y +D +I++ G TA ++ +
Sbjct: 574 MEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGN- 632
Query: 124 EEIRSMLEAVERTQQRKLEELLLAAAREGKTTELTALLNRPNPPDVNCSDQLG--NTPLH 181
E ++ +L + ++ LL A++ G + L + N VNC D G +TPLH
Sbjct: 633 EAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQN---VNCRDLEGRHSTPLH 689
Query: 182 CAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQGAEMKHILVGNKVIYKALKRYEGP 241
AA LL GAD + K+K PL A H V ++
Sbjct: 690 FAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNA--CSYGHYEVAELLVRHGASVNVAD 747
Query: 242 LWK 244
LWK
Sbjct: 748 LWK 750
Score = 66.6 bits (161), Expect = 1e-10
Identities = 45/121 (37%), Positives = 62/121 (51%), Gaps = 9/121 (7%)
Query: 10 LHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLLK 69
LH A N EV + L E AD+N + + G PLH A +GH + L+K
Sbjct: 841 LHLAAGYNNLEVAEYLL-----EHGADVNAQDKG----GLIPLHNAASYGHVDIAALLIK 891
Query: 70 AGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVTHAEEIRSM 129
VN + TPLH AA GR +L LLL + AD T+ N GQT ++ A++IR++
Sbjct: 892 YNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRAL 951
Query: 130 L 130
L
Sbjct: 952 L 952
Score = 49.7 bits (117), Expect = 1e-05
Identities = 54/179 (30%), Positives = 72/179 (40%), Gaps = 41/179 (22%)
Query: 55 ACYFGHRQVVQDLLKAGAEVNVLNDMG--DTPLHRAAFTGRKELVMLLLEYNADTTIVNG 112
AC G V+ L+ A A VN + G +PLH AA GRK++V LL+ A+ +
Sbjct: 189 ACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDD 247
Query: 113 SG----QTAKEVTHAEEIRSMLEAVERTQQRKLEELLLAAAREGKTTELTALLNRPNPPD 168
G A HAE + LLL D
Sbjct: 248 GGLIPLHNACSFGHAEVV----------------SLLLCQGA-----------------D 274
Query: 169 VNCSDQLGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQGAEMKHILVG 227
N D TPLH AA + + LL+ GADPN++N + + LDLA K +L G
Sbjct: 275 PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLAD-PSAKAVLTG 332
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 90.9 bits (224), Expect = 5e-18
Identities = 64/192 (33%), Positives = 94/192 (48%), Gaps = 10/192 (5%)
Query: 32 EVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFT 91
+V+ D K S++ G+TPLH+AC H +V++ LLK GA ++ + + G TPLH A+F
Sbjct: 388 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 447
Query: 92 GRKELVMLLLEYNADTTIVNGSGQT----AKEVTHAEEIRSMLEAVERTQQRKLEEL--L 145
G +V LL+ A + N +T A H E + +L+ + + ++ L
Sbjct: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 507
Query: 146 LAAAREGKTTELTALL-NRPNPPDVNCSDQLGNTPLHCAAYRAHKQCALKLLRSGADPNL 204
AAR G T + LL N NP N + G+TPLH AA H + L LL A
Sbjct: 508 HCAARIGHTNMVKLLLENNANP---NLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 564
Query: 205 KNKNDQKPLDLA 216
K PL +A
Sbjct: 565 MTKKGFTPLHVA 576
Score = 79.7 bits (195), Expect = 1e-14
Identities = 61/173 (35%), Positives = 79/173 (45%), Gaps = 8/173 (4%)
Query: 50 TPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTI 109
TPLH+A + GH +V + LL GA+ N G TPLH A ++ LLL+ A
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432
Query: 110 VNGSGQTAKEVT----HAEEIRSMLE--AVERTQQRKLEELLLAAAREGKTTELTALLNR 163
V SG T V H ++++L+ A K+E L AAR G T LL
Sbjct: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ- 491
Query: 164 PNPPDVNCSDQLGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLA 216
N VN + TPLHCAA H LL + A+PNL PL +A
Sbjct: 492 -NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 543
Score = 77.4 bits (189), Expect = 6e-14
Identities = 74/257 (28%), Positives = 115/257 (44%), Gaps = 22/257 (8%)
Query: 13 ARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLLKAGA 72
++ G+ + V +LL E+I + K G T LH+A G +VV++L+ GA
Sbjct: 86 SKEGHVKMVVELLH----KEIILETTTKK------GNTALHIAALAGQDEVVRELVNYGA 135
Query: 73 EVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQT----AKEVTHAEEIRS 128
VN + G TPL+ AA E+V LLE A+ + G T A + H +
Sbjct: 136 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 195
Query: 129 MLEAVERTQQRKLEELLLAAAREGKTTELTALLNRPNPPDVNCSDQLGNTPLHCAAYRAH 188
++ + + R L L +AA + T L N PNP + + G TPLH AA+ +
Sbjct: 196 LINYGTKGKVR-LPALHIAARNDDTRTAAVLLQNDPNP---DVLSKTGFTPLHIAAHYEN 251
Query: 189 KQCALKLLRSGADPNLKNKNDQKPLDLAQ---GAEMKHILVGNKVIYKALKRYE-GPLWK 244
A LL GA N +N PL +A M +L+ + + E PL
Sbjct: 252 LNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 311
Query: 245 SSRFFGWRLFWVVLEHG 261
++R R+ ++L+HG
Sbjct: 312 AARNGHVRISEILLDHG 328
Score = 77.0 bits (188), Expect = 8e-14
Identities = 58/180 (32%), Positives = 83/180 (46%), Gaps = 16/180 (8%)
Query: 48 GWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADT 107
G+TPLH+A +V + LL+ G N + G TPLH AA G E+V LLL A+
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 694
Query: 108 TIVNGSGQTAKEVTHAE----------EIRSMLEAVERTQQRKLEELLLAAAREGKTTEL 157
+ N SG T + E + M++A R L A+ G +
Sbjct: 695 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH----VASHYGNIKLV 750
Query: 158 TALLNRPNPPDVNCSDQLGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQ 217
LL + DVN +LG +PLH AA + H LL++GA PN + + PL +A+
Sbjct: 751 KFLLQ--HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 808
Score = 73.6 bits (179), Expect = 8e-13
Identities = 72/258 (27%), Positives = 113/258 (43%), Gaps = 22/258 (8%)
Query: 13 ARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLLKAGA 72
+R GN VR LL+ A+ E ++K L TPLH A GH ++ + LL GA
Sbjct: 280 SRRGNVIMVRLLLDRGAQIET--------KTKDEL--TPLHCAARNGHVRISEILLDHGA 329
Query: 73 EVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVT----HAEEIRS 128
+ G +P+H AA + V LLL+Y+A+ + T V H +
Sbjct: 330 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 389
Query: 129 MLEAVERTQQRKLEEL--LLAAAREGKTTELTALLNRPNPPDVNCSDQLGNTPLHCAAYR 186
+L+ + R L L A ++ + LL ++ + G TPLH A++
Sbjct: 390 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK--TGASIDAVTESGLTPLHVASFM 447
Query: 187 AHKQCALKLLRSGADPNLKNKNDQKPLDLAQGA---EMKHILVGNKVIYKA-LKRYEGPL 242
H LL+ GA PN+ N + PL +A A E+ L+ NK A K + PL
Sbjct: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 507
Query: 243 WKSSRFFGWRLFWVVLEH 260
++R + ++LE+
Sbjct: 508 HCAARIGHTNMVKLLLEN 525
Score = 67.8 bits (164), Expect = 5e-11
Identities = 76/269 (28%), Positives = 109/269 (40%), Gaps = 29/269 (10%)
Query: 6 EQQLLH-HARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVV 64
+Q LH AR G+ V+ LLE N + G TPLH+A GH + V
Sbjct: 503 DQTPLHCAARIGHTNMVKLLLEN----------NANPNLATTAGHTPLHIAAREGHVETV 552
Query: 65 QDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVTHAE 124
LL+ A + G TPLH AA G+ + LLLE +A N +G+ H
Sbjct: 553 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVA 609
Query: 125 EIRSMLEAVERTQQR---------KLEELLLAAAREGKTTELTALLNRPNPPDVNCSDQL 175
+ L+ V+ R L AA++ + +LL N
Sbjct: 610 VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG--SANAESVQ 667
Query: 176 GNTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQ---GAEMKHILVGNKVIY 232
G TPLH AA H + LL A+ NL NK+ PL L + +L+ + V+
Sbjct: 668 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 727
Query: 233 KALKRY-EGPLWKSSRFFGWRLFWVVLEH 260
A R PL +S + +L +L+H
Sbjct: 728 DATTRMGYTPLHVASHYGNIKLVKFLLQH 756
Score = 64.7 bits (156), Expect = 4e-10
Identities = 65/222 (29%), Positives = 89/222 (40%), Gaps = 42/222 (18%)
Query: 13 ARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLLKAGA 72
ARN + LL+ +V+ S G+TPLH+A ++ + V Q LL GA
Sbjct: 214 ARNDDTRTAAVLLQNDPNPDVL----------SKTGFTPLHIAAHYENLNVAQLLLNRGA 263
Query: 73 EVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVTHAEEIRSMLEA 132
VN G TPLH A+ G +V LLL+ A T ++ + L
Sbjct: 264 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE------------TKTKDELTPLHC 311
Query: 133 VERTQQRKLEELLL--AAAREGKTTE----------------LTALLNRPNPPDVNCSDQ 174
R ++ E+LL A + KT + LL D D
Sbjct: 312 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 371
Query: 175 LGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLA 216
L TPLH AA+ H + A LL GA PN + N PL +A
Sbjct: 372 L--TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA 411
Score = 58.5 bits (140), Expect = 3e-08
Identities = 57/188 (30%), Positives = 76/188 (40%), Gaps = 37/188 (19%)
Query: 4 EAEQQLLHHARNGNAEEVR-----QLLETMARNEVIADINCK---GRSKSNLGWTPLHLA 55
E + LL + + NAE V+ L E++A + K G + G TPLHL
Sbjct: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 708
Query: 56 CYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQ 115
GH V L+K G V+ MG TPLH A+ G +LV LL++ AD VN +
Sbjct: 709 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTK 765
Query: 116 TAKEVTHAEEIRSMLEAVERTQQRKLEELLLAAAREGKTTELTALLNRPNPPDVNCSDQL 175
H AA++G T +T LL P+ SD
Sbjct: 766 LGYSPLH------------------------QAAQQGHTDIVTLLLKNGASPNEVSSD-- 799
Query: 176 GNTPLHCA 183
G TPL A
Sbjct: 800 GTTPLAIA 807
Score = 45.4 bits (106), Expect = 2e-04
Identities = 36/102 (35%), Positives = 52/102 (50%), Gaps = 11/102 (10%)
Query: 10 LHHARN-GNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLL 68
LH A + GN + V+ LL+ A D+N +K+ LG++PLH A GH +V LL
Sbjct: 738 LHVASHYGNIKLVKFLLQHQA------DVN----AKTKLGYSPLHQAAQQGHTDIVTLLL 787
Query: 69 KAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIV 110
K GA N ++ G TPL A G + +L +T+ V
Sbjct: 788 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFV 829
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,711,034
Number of Sequences: 37866
Number of extensions: 1742202
Number of successful extensions: 11280
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 365
Number of HSP's successfully gapped in prelim test: 208
Number of HSP's that attempted gapping in prelim test: 7400
Number of HSP's gapped (non-prelim): 2420
length of query: 950
length of database: 18,247,518
effective HSP length: 112
effective length of query: 838
effective length of database: 14,006,526
effective search space: 11737468788
effective search space used: 11737468788
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.