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Search of human proteins with 195539368
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|195539368 coiled-coil domain containing 149 isoform 2 [Homo
sapiens]
(529 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|195539368 coiled-coil domain containing 149 isoform 2 [Homo s... 1036 0.0
gi|27735025 coiled-coil domain containing 149 isoform 1 [Homo sa... 520 e-147
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 66 7e-11
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 66 7e-11
gi|21735548 centrosomal protein 2 [Homo sapiens] 61 3e-09
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 60 5e-09
gi|124249396 coiled-coil domain containing 30 [Homo sapiens] 60 6e-09
gi|16262452 cingulin [Homo sapiens] 59 8e-09
gi|4504063 golgin 97 [Homo sapiens] 59 8e-09
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 59 1e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 59 1e-08
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 59 1e-08
gi|62243374 MAD1-like 1 protein [Homo sapiens] 59 1e-08
gi|62243369 MAD1-like 1 protein [Homo sapiens] 59 1e-08
gi|62243332 MAD1-like 1 protein [Homo sapiens] 59 1e-08
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 58 2e-08
gi|55770834 centromere protein F [Homo sapiens] 58 2e-08
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C... 57 3e-08
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 57 3e-08
gi|33946313 ninein isoform 4 [Homo sapiens] 57 3e-08
gi|33946321 ninein isoform 5 [Homo sapiens] 57 3e-08
gi|148536871 ninein isoform 1 [Homo sapiens] 57 3e-08
gi|148536869 ninein isoform 2 [Homo sapiens] 57 3e-08
gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo sapi... 57 3e-08
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 57 4e-08
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 57 4e-08
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 57 4e-08
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 57 4e-08
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap... 57 5e-08
gi|148612801 KIAA1009 protein [Homo sapiens] 57 5e-08
>gi|195539368 coiled-coil domain containing 149 isoform 2 [Homo
sapiens]
Length = 529
Score = 1036 bits (2680), Expect = 0.0
Identities = 529/529 (100%), Positives = 529/529 (100%)
Query: 1 MEEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQL 60
MEEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQL
Sbjct: 1 MEEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQL 60
Query: 61 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQ 120
RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQ
Sbjct: 61 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQ 120
Query: 121 GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQD 180
GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQD
Sbjct: 121 GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQD 180
Query: 181 VKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSN 240
VKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSN
Sbjct: 181 VKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSN 240
Query: 241 IAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLA 300
IAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLA
Sbjct: 241 IAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLA 300
Query: 301 TALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTL 360
TALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTL
Sbjct: 301 TALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTL 360
Query: 361 PSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPAN 420
PSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPAN
Sbjct: 361 PSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPAN 420
Query: 421 QSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIEGQRSETGP 480
QSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIEGQRSETGP
Sbjct: 421 QSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIEGQRSETGP 480
Query: 481 APPGLAIQGELPKSHLDSFEASRPAAKASTPEDGKGIPEGGGMRSTVKT 529
APPGLAIQGELPKSHLDSFEASRPAAKASTPEDGKGIPEGGGMRSTVKT
Sbjct: 481 APPGLAIQGELPKSHLDSFEASRPAAKASTPEDGKGIPEGGGMRSTVKT 529
>gi|27735025 coiled-coil domain containing 149 isoform 1 [Homo
sapiens]
Length = 267
Score = 520 bits (1339), Expect = e-147
Identities = 267/267 (100%), Positives = 267/267 (100%)
Query: 56 MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQR 115
MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQR
Sbjct: 1 MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQR 60
Query: 116 LGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASV 175
LGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASV
Sbjct: 61 LGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASV 120
Query: 176 DELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVN 235
DELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVN
Sbjct: 121 DELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVN 180
Query: 236 LLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISD 295
LLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISD
Sbjct: 181 LLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISD 240
Query: 296 LKSLATALLETIHEKNMVIQHQRQTNK 322
LKSLATALLETIHEKNMVIQHQRQTNK
Sbjct: 241 LKSLATALLETIHEKNMVIQHQRQTNK 267
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 66.2 bits (160), Expect = 7e-11
Identities = 86/356 (24%), Positives = 146/356 (41%), Gaps = 52/356 (14%)
Query: 25 CKRKLESKKEALLIL---SKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPS- 80
CK K E + L+ KELD+ ++E K LR L R+LI G S
Sbjct: 960 CKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESY 1019
Query: 81 -------------LPPEKRKQAN-------LAQLLRDSQDRNKHLGEEIKELQQRLGEVQ 120
L EK + N L + LR+S + + + + ++L R+ +Q
Sbjct: 1020 KNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQ 1079
Query: 121 GDNKLLRMTI---------------AKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIE 165
+ KLL + I A++ ++ I +E E+L QL++ K+Q++
Sbjct: 1080 SNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQ 1139
Query: 166 SLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQE 225
+L+ + Q D ERL +ELN L+ N+I D++ E + ++
Sbjct: 1140 KTMQELELVKKDAQQTTLMNMEIAD-YERLMKELNQKLTNKNNKIEDLE---QEIKIQKQ 1195
Query: 226 RLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCS 285
+ + L EE+ L+S++ +Y+ E+ K + L A+ +L
Sbjct: 1196 KQETLQEEITSLQSSVQQYE---EKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGE 1252
Query: 286 LPATPQSISDLK---SLATALLETIHE--KNMVIQHQRQTNKILGNRVAELEKKLR 336
L A+ Q + K + T+ IHE K QHQR T RV L+++ R
Sbjct: 1253 LEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQR-TLSAYQQRVTALQEECR 1307
Score = 50.4 bits (119), Expect = 4e-06
Identities = 111/535 (20%), Positives = 209/535 (39%), Gaps = 101/535 (18%)
Query: 30 ESKKEALLILSKELDTC-----QQERDQYKLMANQLRERHQSLKKKYRE---LIDGDPSL 81
ES +E + IL EL Q+ + A+ + E Q L+ + E L++ L
Sbjct: 481 ESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRL 540
Query: 82 PPEKRKQANLAQLLRDSQDRNKHLGEE----IKELQQR---LGEVQGDNKLLRMT----- 129
E K + +L+ + ++ K+L E+ + L QR L E++G K+ +T
Sbjct: 541 QGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEG--KINSLTEEKDD 598
Query: 130 -IAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDEL----QDVKEE 184
I K + E + H E L+ +L + EQ +L+ V+EL ++ +E
Sbjct: 599 FINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKE 658
Query: 185 RSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSN---- 240
+ K+E+L ++ + E +V +L EN L KQL ++ + S
Sbjct: 659 KDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDV 718
Query: 241 -IAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSL 299
+ ++ LE++ + + + L +L +QVQ L + Q LK +
Sbjct: 719 ILKEHITQLEKKLQLMVEEQDN---LNKLLENEQVQKLFVKT---------QLYGFLKEM 766
Query: 300 ATALLETIHEKNMVIQHQRQTNKIL-------------GNRVAELEKKLRTLEVSGLWSL 346
+ + E EK++V Q + +V ELEK+++ L+ +
Sbjct: 767 GSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQC 826
Query: 347 PGGK--------DTILFS---DPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEED 395
K + +L + + +S LL+ + + + ++ Q +E
Sbjct: 827 EELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVS 886
Query: 396 ESCAAAEALTAPEDAG-------RPAVNSPANQSRGNQCKLFHPSLPQLPS--------- 439
++C+ +E E +P + + R + L SL + PS
Sbjct: 887 QTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSV 946
Query: 440 ---EEEVNSLGREI---------IKLTKEQAAAELEEVRRESP-----IEGQRSE 477
EE++ +L +E IKL +A EL+ R+E+ +E RSE
Sbjct: 947 KELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSE 1001
Score = 46.6 bits (109), Expect = 6e-05
Identities = 74/371 (19%), Positives = 145/371 (39%), Gaps = 46/371 (12%)
Query: 9 DRTESDWQGLVSEYLVCKR---KLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQ 65
+ +S+ + L S+ L K K + + LLI +E+ + + + + H+
Sbjct: 848 EEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHE 907
Query: 66 SLKK--KYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGD- 122
+LK + +EL D L K A + D K L E+I+ L++ E +
Sbjct: 908 NLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKI 967
Query: 123 NKLLRMTIAKQRLGDEAIGVRHFAAHEREDL----------VQQLERAKEQIESLEHDLQ 172
NK+ + + ++ D + E E L ++ L + E ++L + +
Sbjct: 968 NKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYE 1027
Query: 173 ASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHE 232
++L KE ++++ ++E L ++L N + + + +N L R++ L
Sbjct: 1028 KQSEQLDVEKERANNFEHRIEDLTRQLR-------NSTLQCETINSDNEDLLARIETLQS 1080
Query: 233 EVNLLKSNIAKYKNA-------LERRKNSKGQGKSSSSALTGVLSAKQVQ---------- 275
LL+ I + + A LE K K Q + L QVQ
Sbjct: 1081 NAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQK 1140
Query: 276 -----DLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAE 330
+L+ +D I+D + L L + + KN I+ Q KI +
Sbjct: 1141 TMQELELVKKD-AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQET 1199
Query: 331 LEKKLRTLEVS 341
L++++ +L+ S
Sbjct: 1200 LQEEITSLQSS 1210
Score = 45.8 bits (107), Expect = 1e-04
Identities = 69/332 (20%), Positives = 143/332 (43%), Gaps = 36/332 (10%)
Query: 26 KRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEK 85
+++LE L LS++L D K + ++ + +++ L + EK
Sbjct: 153 QKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEK 212
Query: 86 RKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHF 145
++ + QL + ++H + I LQ+ +LL++ Q E +
Sbjct: 213 KE--TVTQLQNIIEANSQHYQKNINSLQE---------ELLQLKAIHQEEVKELMCQIEA 261
Query: 146 AAHEREDLVQQLERAKE----QIESLEHDLQASVD-ELQDVKEERSSYQDKVERLNQELN 200
+A E E + +L KE Q E+ E ++Q + EL+++++ S+ NQ +
Sbjct: 262 SAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQD----NQICS 317
Query: 201 HILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKS 260
+L EN ++ + + ++L++ LK+L + ++LK + Y N L+ + Q
Sbjct: 318 ILLQ--ENTFVE-QVVNEKVKHLEDTLKELESQHSILKDEVT-YMNNLKLKLEMDAQHIK 373
Query: 261 SSSALTGVLSAKQVQDLL--SEDHGCSLPATPQSISDLKSLATALLETIHEKNMVI---- 314
++ +LL E+ GC + S+L L T+ + N +
Sbjct: 374 DEFFHEREDLEFKINELLLAKEEQGCVIEKLK---SELAGLNKQFCYTVEQHNREVQSLK 430
Query: 315 -QHQRQTNKILGNRVAELEKKLRTL--EVSGL 343
QHQ++ +++ +++ EK+ TL E+ GL
Sbjct: 431 EQHQKEISELNETFLSDSEKEKLTLMFEIQGL 462
Score = 38.1 bits (87), Expect = 0.020
Identities = 39/181 (21%), Positives = 82/181 (45%), Gaps = 18/181 (9%)
Query: 26 KRKLESKKEA----LLI---LSKELDTCQQERDQYKL-MANQLRERHQSLKKKYRELIDG 77
K++L K+A L++ L EL+ QQ+ + YK+ +A E+H+ +
Sbjct: 1229 KKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQH 1288
Query: 78 DPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGD 137
+L +++ L + R ++ + E + + R+ V K M+ A+
Sbjct: 1289 QRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETE--- 1345
Query: 138 EAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQ 197
A ERE L +++ K +++ +++LQ +V ELQ ++ E + ++ ++ Q
Sbjct: 1346 -------GAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQ 1398
Query: 198 E 198
E
Sbjct: 1399 E 1399
Score = 36.6 bits (83), Expect = 0.058
Identities = 55/235 (23%), Positives = 89/235 (37%), Gaps = 39/235 (16%)
Query: 1 MEEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQL 60
M + G + E + ++ + L K KL+ + L I EL T Q E D L
Sbjct: 1339 MSQAETEGAKQEREHLEMLIDQL--KIKLQDSQNNLQINVSELQTLQSEHD-------TL 1389
Query: 61 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQ 120
ERH + L K+A L + L Q N + E Q + ++
Sbjct: 1390 LERHNKM-------------LQETVSKEAELREKLCSIQSENMMMK---SEHTQTVSQLT 1433
Query: 121 GDNKLLRMTIAKQRLGDEAIGVRHFAAHER---EDLVQQLERAKEQIESLEHD--LQASV 175
N++LR + Q VRH R E L QQL + + Q+ L+++ ++ V
Sbjct: 1434 SQNEVLRNSFRDQ--------VRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPV 1485
Query: 176 DELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQL 230
Q +K R + L+ G D +++ + Y Q L+QL
Sbjct: 1486 SSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQS-LEQL 1539
Score = 34.3 bits (77), Expect = 0.29
Identities = 56/267 (20%), Positives = 112/267 (41%), Gaps = 25/267 (9%)
Query: 91 LAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHER 150
L LLRD + L +E++E+Q +Q D ++ K RL ++ + + +
Sbjct: 829 LKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLI------QV 882
Query: 151 EDLVQ-----QLERAKEQIESLEHD-LQASVD--ELQDVKEERSSYQDKVERLNQELNHI 202
E++ Q ++ KE+ EH+ L+ ++ EL+D + E +D + + N
Sbjct: 883 EEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDP 942
Query: 203 LSG---HENRIIDVDALCMENRYLQERLK----QLHEEVNLLKSNIAKYKNALERRKNSK 255
LS E +I +++ C E ++K + +E++ + K LE ++ K
Sbjct: 943 LSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEK 1002
Query: 256 GQGKSSSSALTGVLSAKQVQDLLSEDHGCS--LPATPQSISDLKSLATALLETIHEKNMV 313
Q +S L + A+ ++LL E S L + ++ + L + +
Sbjct: 1003 DQLSASMRDL--IQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQ 1060
Query: 314 IQHQRQTNKILGNRVAELEKKLRTLEV 340
+ N+ L R+ L+ + LEV
Sbjct: 1061 CETINSDNEDLLARIETLQSNAKLLEV 1087
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 66.2 bits (160), Expect = 7e-11
Identities = 71/317 (22%), Positives = 144/317 (45%), Gaps = 23/317 (7%)
Query: 29 LESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQ 88
LE +E L I S +++ QQE K +++E Q L++K + +R
Sbjct: 810 LEKLREELAIKSGQVEHLQQETAALKKQMQKIKE--QFLQQKVM--------VEAYRRDA 859
Query: 89 ANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAH 148
+ QL+ + + K L E+KEL+Q L +V G+ + ++ RL E VR A
Sbjct: 860 TSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELS--RLHREVAQVRQHMA- 916
Query: 149 EREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHEN 208
+ E +Q ++ ++++E+ LQ +++ V E + + ++E L QE ++ +
Sbjct: 917 DLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQ 976
Query: 209 RIIDVDA-LCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKG----QGKSSSS 263
++ + + L + ++ + K V +L + + A E G QG SS S
Sbjct: 977 KMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDS 1036
Query: 264 ALTGVLSAKQVQDLLSEDHGCSLPAT--PQSISDLKSLATALLETIHEKNMVIQHQRQTN 321
+L +++Q L +E S T + + ++ +L + LE EK + ++ + Q +
Sbjct: 1037 SLA---LHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQES 1093
Query: 322 KILGNRVAELEKKLRTL 338
+ ++ LE+ + L
Sbjct: 1094 RGFRKKIKRLEESNKKL 1110
Score = 47.0 bits (110), Expect = 4e-05
Identities = 69/343 (20%), Positives = 140/343 (40%), Gaps = 31/343 (9%)
Query: 12 ESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERH------- 64
E +Q L+++ +R + SK + L +++ Q + Q +L L +
Sbjct: 509 EEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEI 568
Query: 65 ---QSLKKKYRELIDGDPSLPPEKRK--QANLAQLLRDSQDRN---KHLGEEIKELQQRL 116
QS+++ Y++ + +L E R Q +A + + +HL E L Q+L
Sbjct: 569 SSLQSVRQWYQQQL----ALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQL 624
Query: 117 GEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVD 176
E Q + + IA Q G EA + ++E Q++ AK +E DLQ ++
Sbjct: 625 TETQHRSMKEKGRIAAQLQGIEADML------DQEAAFMQIQEAKTMVEE---DLQRRLE 675
Query: 177 ELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNL 236
E + +E D L Q+L + R ++AL E+ L ++L E +
Sbjct: 676 EFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQS 735
Query: 237 LKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDL 296
+ ++ + + + G+ + +++ + Q + ++ E +L A +L
Sbjct: 736 REQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILE---AALQAAKSGKEEL 792
Query: 297 KSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLE 339
A L E E + ++ R+ I +V L+++ L+
Sbjct: 793 DRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALK 835
Score = 46.2 bits (108), Expect = 7e-05
Identities = 69/339 (20%), Positives = 138/339 (40%), Gaps = 43/339 (12%)
Query: 27 RKLESKKEALLILSKELDTCQQERDQYKLMANQLR----------ERHQSLKKKYRELI- 75
R++ ++ + L L + Q+ERD+ + L+ E +++LKK+ EL
Sbjct: 906 REVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQ 965
Query: 76 DGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRL 135
+ ++ +K+K L L +Q K + + K + +G I +RL
Sbjct: 966 EARKAITEQKQKMRRLGSDLTSAQ---KEMKTKHKAYENAVG------------ILSRRL 1010
Query: 136 GDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERL 195
EA+ + A E L Q + + +L +QA ELQ V ++ + +++ +
Sbjct: 1011 -QEALAAKEAADAELGQLRAQGGSSDSSL-ALHERIQALEAELQAVSHSKTLLEKELQEV 1068
Query: 196 NQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSK 255
+ L ++++++ E+R ++++K+L E L + K L S
Sbjct: 1069 IALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSN 1128
Query: 256 GQGKSSSSALTGVLSAK---------QVQDLL----SEDHGCS--LPATPQSISDLKSLA 300
+ +S L L+ + QVQ +L ED + A S+ K
Sbjct: 1129 AALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKV 1188
Query: 301 TALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLE 339
+L E + + H R+ K ++E++K+L+ E
Sbjct: 1189 NSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKE 1227
Score = 45.1 bits (105), Expect = 2e-04
Identities = 104/523 (19%), Positives = 209/523 (39%), Gaps = 89/523 (17%)
Query: 18 LVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLR-------------ERH 64
L S K K ++ + A+ ILS+ L ++ QLR ER
Sbjct: 985 LTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERI 1044
Query: 65 QSLKKKYRELIDGDPSLPPEKRKQANL-AQLLRDSQDRNKHLGEEIKE---LQQRLGEVQ 120
Q+L+ + + + L E ++ L +Q L +S+++ L +E++E ++++ ++
Sbjct: 1045 QALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLE 1104
Query: 121 GDNKLLRMTIAKQR-----LGDEAIGVRHF-------AAHEREDLVQQ-------LERAK 161
NK L + + ++ LG +R A DLVQ L+R +
Sbjct: 1105 ESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKE 1164
Query: 162 EQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENR 221
E+ ++H +QA L+ KE+ +S +++V E H + +++ + E +
Sbjct: 1165 EEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQ 1224
Query: 222 YLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSED 281
+ +++L E + L+ K+ + + + + ++ L KQ+ + LS+
Sbjct: 1225 AKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLL-----QKQLDEQLSKQ 1279
Query: 282 HGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVS 341
P Q + +LK + +K IQ +Q +L ++ E+
Sbjct: 1280 -----PVGNQEMENLK-------WEVDQKEREIQSLKQQ--------LDLTEQQGRKELE 1319
Query: 342 GLWS-LPGGKDTILFSDPTLPSGQRS-----------RSPLLKFVEQPTENKADPKDGEA 389
GL L K + + L Q+ ++ + ++Q + K D + G A
Sbjct: 1320 GLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAA 1379
Query: 390 QKQEEDESCAAAEALTAP---EDAGRPA-----VNSPANQSRGNQCKLFHPSLPQLPSEE 441
+ ++E + A++ P D PA + P K + L QL ++
Sbjct: 1380 KTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQL--KQ 1437
Query: 442 EVNSLGREIIKLTKEQAAAELEEVRRESPIEGQRSETGPAPPG 484
E++SL R++ +E A E + +P+E + P PPG
Sbjct: 1438 EMDSLQRQM----EEHALTVHESLSSWTPLE--PATASPVPPG 1474
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 60.8 bits (146), Expect = 3e-09
Identities = 122/548 (22%), Positives = 208/548 (37%), Gaps = 90/548 (16%)
Query: 11 TESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQ-------QERDQYKLMANQLRER 63
++ D+Q + + L +++A+ L ++L CQ Q+ DQ++ LR+R
Sbjct: 377 SQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQR 436
Query: 64 HQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDN 123
Q L + L L E + +LL Q + L ++++ L+Q
Sbjct: 437 LQKLTGERDTLAGQTVDLQGEVDSLSKERELL---QKAREELRQQLEVLEQEAW------ 487
Query: 124 KLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKE 183
+L R+ + Q GD A G + E V++ ER +E + LE S+ EL ++E
Sbjct: 488 RLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLRE 547
Query: 184 ERSSYQDKVERLNQELNHI-------------LSGHEN----RIIDV-----------DA 215
S + E L QE + LS EN + D+ +A
Sbjct: 548 ALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEA 607
Query: 216 LCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQ 275
L ++ L ++L QL EE + S + + A + + + AL + + Q
Sbjct: 608 LALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQ 667
Query: 276 DLLSEDHGCSLPATPQSISDLK--------------SLATALLETIHE----KNMVIQHQ 317
+E+ G L A + I + K AT LE +H+ + V+
Sbjct: 668 LQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARA 727
Query: 318 RQTNKILGNRVAELEKKLRTLE---------VSGLWSLPGGKDTILFSDPTLPSGQRSRS 368
Q + L A LE +L+ +E + GL S ++ LF S
Sbjct: 728 VQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTK 787
Query: 369 PLLKFVEQPTENKADPKDGEA----------QKQEEDESCAAAEALTAPEDAGRPAV--N 416
L+ Q + GE + Q E E AAA L E G+ A+
Sbjct: 788 GQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ 847
Query: 417 SPANQSRGNQCK---LFHPSLPQLPSEEEVNSLGREIIKL---TKEQAAAELEEVRRESP 470
A++ NQ + S Q + + SL RE ++L KEQ E+E ++ +
Sbjct: 848 KAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQ-QTEMEAIQAQRE 906
Query: 471 IEGQRSET 478
E ++E+
Sbjct: 907 EERTQAES 914
Score = 57.0 bits (136), Expect = 4e-08
Identities = 112/489 (22%), Positives = 200/489 (40%), Gaps = 63/489 (12%)
Query: 29 LESKKEALLILSKELDTCQQERD-QYKLMANQLRERHQSLKKKYRELID--------GDP 79
LE + + L++ + + + +R Q K++ L + SL+++ REL +
Sbjct: 1653 LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE 1712
Query: 80 SLPPEKRKQANLAQL---LRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLG 136
P K ++ +L + LRD + + E I ELQ+ +++ + L + + L
Sbjct: 1713 GKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSL- 1771
Query: 137 DEAIGVRHFAAHEREDLV--QQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVER 194
+ E+E +V QQL+ A+EQ E E LQ+ +DE Q +R ++E
Sbjct: 1772 -------LLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ---ELEA 1821
Query: 195 LNQELNHILSGHENRIID-VDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKN 253
L QE G E R+ + DAL LK+ H E+ K + LE
Sbjct: 1822 LQQEQQQ-AQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARR----LEEELA 1876
Query: 254 SKGQGKSSSSALTGVL---SAKQVQDLLSEDHGCSLPA-----TPQSISDLKSLATAL-- 303
+G+ + + G L S +Q + LL+ C+ A +++ D A A+
Sbjct: 1877 VEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLK 1936
Query: 304 -----LETIHEKNMVIQHQRQT--------NKILGNRVAELE-KKLRTLEVSGL-WSLPG 348
LE + ++ +HQ + + LG A L+ K+ LE + L SL
Sbjct: 1937 ERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEA 1996
Query: 349 GKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAEALTAPE 408
T+ S + R L+ E +++ D + E +Q + E L +
Sbjct: 1997 STATLQASLDACQAHSRQLEEALRIQEGEIQDQ-DLRYQEDVQQLQQALAQRDEELRHQQ 2055
Query: 409 DAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKL-----TKEQAAAELE 463
+ + S A + + N + +L Q EEE+ L + + +L KEQ EL
Sbjct: 2056 EREQLLEKSLAQRVQENMIQ-EKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELR 2114
Query: 464 EVRRESPIE 472
E ++ + +E
Sbjct: 2115 ETQQRNNLE 2123
Score = 51.2 bits (121), Expect = 2e-06
Identities = 68/298 (22%), Positives = 127/298 (42%), Gaps = 20/298 (6%)
Query: 38 ILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRD 97
IL ++L T + RER Q+L+++ G+ + K Q NLA L +
Sbjct: 1376 ILEEDLRTARSALKLKNEEVESERERAQALQEQ------GELKVAQGKALQENLALLTQT 1429
Query: 98 SQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQL 157
+R EE++ L+ G++Q K M A L + R+ +++ +Q+L
Sbjct: 1430 LAERE----EEVETLR---GQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL 1482
Query: 158 ERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALC 217
E+ + +E L +Q +L +E+ + E L H L E + +++
Sbjct: 1483 EKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQR 1542
Query: 218 MENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDL 277
+ + L+++L L L+ N K + + K +GQ ++ ALT + L
Sbjct: 1543 GQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHL-------TL 1595
Query: 278 LSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKL 335
E+ L A I DL+S +T L + E++ ++ QR+ + L + L + L
Sbjct: 1596 DLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDL 1653
Score = 51.2 bits (121), Expect = 2e-06
Identities = 76/383 (19%), Positives = 159/383 (41%), Gaps = 49/383 (12%)
Query: 29 LESKKEALLILSKELDTCQQERD-QYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRK 87
++ +++ L + +++ +++R+ Q ++ +QL E L+KK ++I+ + +K
Sbjct: 1496 VQEREQKLTVQREQIRELEKDRETQRNVLEHQLLE----LEKK-DQMIESQRGQVQDLKK 1550
Query: 88 QANLAQLLRDSQDRNKHLGEEIKELQQRL-GEVQGDNKLLRMTIAKQRLGDEAIGVRHFA 146
Q + L + N H E QQ+L E++G + R+ + L
Sbjct: 1551 QLVTLECLALELEENHHK----MECQQKLIKELEGQRETQRVALTHLTL----------- 1595
Query: 147 AHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGH 206
+ E+ Q+L+ QI LE ELQ+ +E S ++++E L ++ H+
Sbjct: 1596 --DLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDL 1653
Query: 207 ENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERR-----------KNSK 255
E R L ++ +Q Q + +L+ ++ + K +L R +
Sbjct: 1654 ERR---DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710
Query: 256 GQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATAL---LETIHEK-- 310
+GK S A G L + L+ D + + I +L+ L L L+ +H K
Sbjct: 1711 EEGKGPSKAQRGSL---EHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767
Query: 311 --NMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRS 368
++++ + Q +L ++ E ++ E S L + + D L + Q+ +
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQ 1827
Query: 369 PLLKFVEQPTENKADPKDGEAQK 391
+ E+ + KAD G ++
Sbjct: 1828 Q-AQGQEERVKEKADALQGALEQ 1849
Score = 50.1 bits (118), Expect = 5e-06
Identities = 88/391 (22%), Positives = 172/391 (43%), Gaps = 63/391 (16%)
Query: 2 EEEAMNGDRTESDWQGLVSEYLVCKRKLESKK------EALLILSKEL-DTCQQ------ 48
E EA+ R E Q +E +C+ +LE++K E LL KEL D QQ
Sbjct: 897 EMEAIQAQREEERTQ---AESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQ 953
Query: 49 --------ERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEK----RKQANLAQLLR 96
E++ ++ QL+E + LK+ R+ D +L E + + +L + +
Sbjct: 954 DMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVE 1013
Query: 97 D------SQDRNKHLGEEIKELQQRLGEVQGDNKLLR--------MTIAKQRLGDEAIGV 142
D +QD ++ L E+ E+Q++L E Q N++ + +T++ ++ + V
Sbjct: 1014 DLKSQLVAQDDSQRLVEQ--EVQEKLRETQEYNRIQKELEREKASLTLSLME-KEQRLLV 1070
Query: 143 RHFAAHEREDLVQQLERAKEQIESLEHDLQASVDEL-QDVKEERSSYQDKVERLNQELNH 201
A R+ + L + ++ + + +L A ++ L Q+VKE+ + + + +L +EL
Sbjct: 1071 LQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEA 1130
Query: 202 ILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLL------------KSNIAKYKNALE 249
+ + A + LQ RL+ ++ L ++ +A +AL+
Sbjct: 1131 SHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQ 1190
Query: 250 RRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGC-SLPATPQSISDLKSLATALLETIH 308
+ S + + S G SA V L + +G SL ++ L A A+ +H
Sbjct: 1191 QALGSVCESRPELSG--GGDSAPSVWGLEPDQNGARSLFKRGPLLTALS--AEAVASALH 1246
Query: 309 EKNMVIQHQRQTNKILGNRVAELEKKLRTLE 339
+ + + +QT +L ++V +LE++L E
Sbjct: 1247 KLHQDLWKTQQTRDVLRDQVQKLEERLTDTE 1277
Score = 43.5 bits (101), Expect = 5e-04
Identities = 122/548 (22%), Positives = 211/548 (38%), Gaps = 103/548 (18%)
Query: 29 LESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQ 88
L+ ++E + S+ ++ +Q R+ ++ + +R ++L +K L + L +
Sbjct: 620 LQLEEENQSVCSR-MEAAEQARNALQVDLAEAEKRREALWEKNTHL---EAQLQKAEEAG 675
Query: 89 ANLAQLLRDSQDRNKHLGEEIKELQQR-------LGEVQGDNKLLRMTIAKQRLGDEAIG 141
A L LRD Q+ + + +++ E + + L ++ + K +A+ EA+
Sbjct: 676 AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEAL- 734
Query: 142 VRHFAAHE---------REDLVQQLE---RAKEQIES--LEHDLQASVDE---------L 178
VR AA E R+DL +QL+ AKE +ES E Q SV E +
Sbjct: 735 VREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQI 794
Query: 179 QDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALC-------MENRYLQERLKQLH 231
Q V + + Q +V L EL+ S E + DA E + E+ K H
Sbjct: 795 QTVTQAKEVIQGEVRCLKLELDTERSQAEQ---ERDAAARQLAQAEQEGKTALEQQKAAH 851
Query: 232 E-EVNLLKSN-----------IAKYKNALERRKNS-KGQGKSSSSALTGVLSAKQVQDLL 278
E EVN L+ +AK +LER K + + K + + + + ++ +
Sbjct: 852 EKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQ 911
Query: 279 SEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTL 338
+E C + LET E+ +++ QT K L + +LE+ + +
Sbjct: 912 AESALCQMQ----------------LETEKERVSLLETLLQTQKELADASQQLERLRQDM 955
Query: 339 EVSGLWSLPGGKDTILFSDPTLPSGQRS--------RSPLLKFVEQPTENKADPKDGEAQ 390
+V L ++T L QR R L E+ + D D Q
Sbjct: 956 KVQKLKE----QETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMD--LQ 1009
Query: 391 KQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREI 450
KQ ED L A +D+ R + R Q ++ E E +
Sbjct: 1010 KQVED----LKSQLVAQDDSQRLVEQEVQEKLRETQ------EYNRIQKELEREKASLTL 1059
Query: 451 IKLTKEQAAAELEE---VRRE--SPIEGQRSETGPAPPGLAIQGELPKSHLDSFEASRPA 505
+ KEQ L+E +R++ S + E L+ Q EL + + EA A
Sbjct: 1060 SLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLA 1119
Query: 506 AKASTPED 513
+A E+
Sbjct: 1120 QEAQLLEE 1127
Score = 42.7 bits (99), Expect = 8e-04
Identities = 93/465 (20%), Positives = 169/465 (36%), Gaps = 129/465 (27%)
Query: 1 MEEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQL 60
++E G+ E Q + E +R L + + L L +E Q + ++ K A+ L
Sbjct: 1787 LQEAREQGELKEQSLQSQLDE---AQRALAQRDQELEALQQEQQQAQGQEERVKEKADAL 1843
Query: 61 R----ERHQSLKKKYRELIDG-------DPSLPPEKRKQANLAQLLRDSQDRNKHLGEEI 109
+ + H +LK+++ EL D + L E R+ L ++L D + ++ + +
Sbjct: 1844 QGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKAL 1903
Query: 110 KELQQRLGE----------VQGDNKLLRMTIAKQRLGD---------------------- 137
LQQ+ E D+ L + K+R +
Sbjct: 1904 LALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARA 1963
Query: 138 ----EAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQ-------------- 179
EA+G H A +E + + +E+ LQAS+D Q
Sbjct: 1964 EALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQE 2023
Query: 180 -DVKEERSSYQDKVERLNQ-------ELNH------------ILSGHENRIIDVDALCME 219
+++++ YQ+ V++L Q EL H EN I + L E
Sbjct: 2024 GEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQE 2083
Query: 220 NRYLQERLKQLHEEVNLLKSNIAKYKNAL------ERRKNSKGQGKSSSSA--------- 264
+E ++ LH+ V L+ +A+ + + ++R N + S ++
Sbjct: 2084 RE--EEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKL 2141
Query: 265 -------------LTGVLSAKQVQDL----LSEDHGCSLPATPQSISDLKSLATALLETI 307
L L + +++ ++D SL T S+S L+ +A L ++
Sbjct: 2142 DSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASV 2201
Query: 308 HEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDT 352
E++ Q + ELE R LE L S PG T
Sbjct: 2202 LERDSEQQRLQD----------ELELTRRALEKERLHS-PGATST 2235
Score = 35.8 bits (81), Expect = 0.099
Identities = 63/314 (20%), Positives = 129/314 (41%), Gaps = 45/314 (14%)
Query: 56 MANQLRERHQSLKK--KYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQ 113
+A+ L + HQ L K + R+++ + + L + L D++ + E+++LQ
Sbjct: 1241 VASALHKLHQDLWKTQQTRDVL---------RDQVQKLEERLTDTEAEKSQVHTELQDLQ 1291
Query: 114 QRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDL----VQQLERA--KEQIESL 167
++L + Q + + + L E + + A + L +Q++E +E +++
Sbjct: 1292 RQLSQNQEEKS--KWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAA 1349
Query: 168 EHDLQASVDELQ------------------DVKEERSSYQDKVERLNQELNHILSGHEN- 208
+ +L A V+ LQ D++ RS+ + K E + E + E
Sbjct: 1350 KENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQG 1409
Query: 209 --RIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALT 266
++ AL L + L + EEV L+ I + + E +K +
Sbjct: 1410 ELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRN 1469
Query: 267 GVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNK-ILG 325
+ +Q Q E L P ++ + + T E I E ++ R+T + +L
Sbjct: 1470 QEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRE----LEKDRETQRNVLE 1525
Query: 326 NRVAELEKKLRTLE 339
+++ ELEKK + +E
Sbjct: 1526 HQLLELEKKDQMIE 1539
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 60.1 bits (144), Expect = 5e-09
Identities = 120/496 (24%), Positives = 212/496 (42%), Gaps = 81/496 (16%)
Query: 26 KRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEK 85
+R LES + KE Q ++Y+ A Q E+ ++++ + L D
Sbjct: 474 RRNLESTVSQI---EKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKD--------- 521
Query: 86 RKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHF 145
+ +L ++ ++SQ N E++ +LQ++L E N LLR D A+ +R
Sbjct: 522 -QLEDLKKVSQNSQLAN----EKLSQLQKQLEEA---NDLLRTE------SDTAVRLRK- 566
Query: 146 AAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSG 205
+H ++ ++ Q+ESL +LQ L++ K + +++ + E G
Sbjct: 567 -SHT------EMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAI-LEAERRDRG 618
Query: 206 HENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSAL 265
H++ +I LQ R+ L EEV LK N+ K + + ++ + + L
Sbjct: 619 HDSEMIGD---------LQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNL 669
Query: 266 TGVLS--AKQVQDLLSEDHG------CSLPATPQSISDLKSLATALLETIHEKNMVIQHQ 317
L+ K +Q L ++ L QSI + KS+A +E ++ +
Sbjct: 670 EIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEK------KLKEE 723
Query: 318 RQTNKILGNRVAELEKKLRTLEV------SGLWSLPGGKDTI--LFSDPTLPSGQRSRSP 369
R+ + NRV ++EK+ L+V L L G K+ + + TL Q S
Sbjct: 724 REAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKR 783
Query: 370 LLKFVEQPTEN-KADPKDG-EAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQC 427
LL E T+ +AD G E Q ++E + A+ L E A Q RGN+
Sbjct: 784 LLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELA------QLTKQYRGNEG 837
Query: 428 KLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIEGQRSETGPAPPGLAI 487
++ QL +E+ ++L + +K KE E+EE RE+ + Q E LA
Sbjct: 838 QM-RELQDQLEAEQYFSTLYKTQVKELKE----EIEEKNRENLKKIQ--ELQNEKETLAT 890
Query: 488 QGELPKSHLDSFEASR 503
Q +L ++ +S + +R
Sbjct: 891 QLDLAETKAESEQLAR 906
Score = 51.2 bits (121), Expect = 2e-06
Identities = 67/337 (19%), Positives = 141/337 (41%), Gaps = 36/337 (10%)
Query: 16 QGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELI 75
Q ++EY +RK E + E + E+ T + + + K ++ + ++ L + ++L
Sbjct: 492 QHRINEY---QRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLE 548
Query: 76 DGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLL---RMTIAK 132
+ + L E L + + L +ELQ+R N++L + K
Sbjct: 549 EANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQER-------NRILENSKSQTDK 601
Query: 133 QRLGDEAI--GVRHFAAHERE---DLVQQLERAKEQIESLEHDLQASVDELQDVKEERSS 187
+AI R H+ E DL ++ +E+++ L+H+L+ E ++ ++ +
Sbjct: 602 DYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNH 661
Query: 188 YQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKS-------- 239
+ + L +LN+ L + R+ + E++ + RL H+ + KS
Sbjct: 662 SEKEKNNLEIDLNYKLKSLQQRL---EQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEK 718
Query: 240 NIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSL 299
+ + + A E+ +N Q + S L + KQ Q L L + + D
Sbjct: 719 KLKEEREAREKAENRVVQIEKQCSMLD--VDLKQSQQKLEH-----LTGNKERMEDEVKN 771
Query: 300 ATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLR 336
T LE K +++Q++ +T + + LEK+++
Sbjct: 772 LTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMK 808
Score = 50.8 bits (120), Expect = 3e-06
Identities = 74/341 (21%), Positives = 144/341 (42%), Gaps = 37/341 (10%)
Query: 1 MEEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQL 60
+E N +R E + + L + LE + L+L EL T E D K + Q+
Sbjct: 755 LEHLTGNKERMEDEVKNLTLQ-------LEQESNKRLLLQNELKTQAFEADNLKGLEKQM 807
Query: 61 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGE----EIKELQQRL 116
++ +L + R L L + R + L+D + ++ ++KEL++ +
Sbjct: 808 KQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEI 867
Query: 117 GEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHD---LQA 173
E +N L+ Q +E+E L QL+ A+ + ES + L+
Sbjct: 868 EEKNREN--LKKIQELQ--------------NEKETLATQLDLAETKAESEQLARGLLEE 911
Query: 174 SVDEL-QDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHE 232
EL Q+ K+ S + ++ + ++ + + D++ L EN L E++K+ E
Sbjct: 912 QYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEE 971
Query: 233 EVNLLK-SNIAKYKNALERRKNSKGQGKSSS-SALTGVLSAKQVQDLLSEDHGCSLPATP 290
E L K I+ K A E+ N++ K+ + + L +++ K D + +
Sbjct: 972 EYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRK---DFKIDRKKANTQDLR 1028
Query: 291 QSISDLKSLATALLETIHEKN-MVIQHQRQTNKILGNRVAE 330
+ + + L L + + N MV++HQ++ N + V E
Sbjct: 1029 KKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEE 1069
>gi|124249396 coiled-coil domain containing 30 [Homo sapiens]
Length = 783
Score = 59.7 bits (143), Expect = 6e-09
Identities = 75/326 (23%), Positives = 143/326 (43%), Gaps = 50/326 (15%)
Query: 38 ILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRD 97
IL E+ + ++E ++ + +L ER Q K+ E + S P E +K+ +Q RD
Sbjct: 126 ILETEIQSRKEETEE---LCPKLGERKQ---KEIPEESVKEGSFPREGQKEEG-SQQNRD 178
Query: 98 SQDRNKHLG-----EEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEA--IGVRHFAAHER 150
+D K EEI L++ L + + + Q GD + G +H ++ E+
Sbjct: 179 MKDEEKEQQLTMKPEEIVRLREELSHIN------QSLLQSQSSGDSSDDSGAQHPSSGEK 232
Query: 151 ---------EDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNH 201
+ L Q L R + S E++L+ + D+K+ S Q++ ++ EL H
Sbjct: 233 LKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKH 292
Query: 202 ILSGHENRIIDVDALC----MENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQ 257
+ +++D +C E ++ Q+++K+L EV +I N E+ K +
Sbjct: 293 A----QQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSK 348
Query: 258 GKSSSSALTGVLSAKQVQDLLSE-DHGCSLPATPQSISDLKSLATALLETIHEKNMV--- 313
+ +++ DL + +H + T IS+ + L + E + V
Sbjct: 349 VADAE---------EKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQ 399
Query: 314 IQHQRQTNKILGNRVAELEKKLRTLE 339
Q ++Q K+L V EL +++RTL+
Sbjct: 400 YQEEQQKRKLLYQNVDELHRQVRTLQ 425
Score = 47.4 bits (111), Expect = 3e-05
Identities = 66/358 (18%), Positives = 138/358 (38%), Gaps = 85/358 (23%)
Query: 1 MEEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKEL---------DTCQQERD 51
+E E + ++ L + + K K+ +E +L L ++L DTC E+
Sbjct: 321 LELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQ 380
Query: 52 QYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKE 111
Q + + + +K++Y+E Q + K L + + E
Sbjct: 381 QLEEKIKEATQNEAKVKQQYQE------------------------EQQKRKLLYQNVDE 416
Query: 112 LQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDL 171
L +++ +Q LL MT ++Q + +QQ E +Q+E+ +
Sbjct: 417 LHRQVRTLQDKENLLEMTCSQQ-----------------QSRIQQQEALLKQLENEKRKY 459
Query: 172 QASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLK--- 228
V Q++ E+ S Q + E L +E +L ++++V ++ Q+++K
Sbjct: 460 DEHVKSNQELSEKLSKLQQEKEALREEYLRLL-----KLLNVHVRNYNEKHHQQKVKLQK 514
Query: 229 ---QLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCS 285
+L EV L I ++++ + ++ + K+ +T Q LL E
Sbjct: 515 VKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITA-----QNDTLLLEKR--- 566
Query: 286 LPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGL 343
L E + E+ +I + T + +RV ++K+ + L+ + L
Sbjct: 567 ----------------KLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSL 608
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 59.3 bits (142), Expect = 8e-09
Identities = 77/313 (24%), Positives = 129/313 (41%), Gaps = 27/313 (8%)
Query: 39 LSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQA-NLAQLLRD 97
L +E+ Q+ + QL E+ + + +EL++ + K+ N+ +LL
Sbjct: 375 LDEEVKKRQKLEPSQVGLERQLEEKTEECSR-LQELLERRKGEAQQSNKELQNMKRLLDQ 433
Query: 98 SQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQL 157
+D L ++ ELQ +L VQG AK+ L + + R E++++
Sbjct: 434 GEDLRHGLETQVMELQNKLKHVQGPEP------AKEVLLKDLLETRELL----EEVLEGK 483
Query: 158 ERAKEQIESLEHDLQASVDEL--------QDVKEERSSYQDKVERLNQELNHILSGHENR 209
+R +EQ+ E +L A L Q+V+ R YQ E+L + + H
Sbjct: 484 QRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVL 543
Query: 210 IIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVL 269
+ + R LQ L++ EE +S K K L K Q + + L
Sbjct: 544 EAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEEL 603
Query: 270 SAK-QVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILG-NR 327
K +V E S T Q ++ L LL T E+ +Q +RQ+ ++ G +R
Sbjct: 604 GEKIEVLQRELEQARASAGDTRQ----VEVLKKELLRT-QEELKELQAERQSQEVAGRHR 658
Query: 328 VAELEKKLRTLEV 340
ELEK+L L V
Sbjct: 659 DRELEKQLAVLRV 671
Score = 47.8 bits (112), Expect = 3e-05
Identities = 66/323 (20%), Positives = 139/323 (43%), Gaps = 23/323 (7%)
Query: 27 RKLESKKEALLILSKELDTCQQERDQY----KLMANQLRERHQSLKKKYRELIDGDPSLP 82
++LE++K+ L + L+ Q+E + + +L E + L + +E + +L
Sbjct: 768 QRLEAEKQQL---EEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALE 824
Query: 83 PEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGV 142
E +++ L + + +++ + L + L + L ++ D+K + Q +
Sbjct: 825 EEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKAR 884
Query: 143 RHFAAHERE--DLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELN 200
R A +R+ D + E+ + L+ ++Q LQ + ER + + E L Q L
Sbjct: 885 REVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQ 944
Query: 201 HILSGHENRIIDVDALCMENRYLQERLKQLHEE-------VNLLKSNIAKYKNALERRKN 253
+ EN+ D + + L+E++ +L E V LL + + ++ +++ +
Sbjct: 945 GLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRT 1004
Query: 254 SKGQGKSSSSAL--TGVLSAKQVQDL---LSEDHGCSLPATPQSISDLKSLATALLETIH 308
Q +S+ L + +Q +DL L+ G P+ S+S L+S L E +
Sbjct: 1005 ELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSA--SLSQLESQNQLLQERLQ 1062
Query: 309 EKNMVIQHQRQTNKILGNRVAEL 331
+ + TN+ L +V EL
Sbjct: 1063 AEEREKTVLQSTNRKLERKVKEL 1085
Score = 46.6 bits (109), Expect = 6e-05
Identities = 61/293 (20%), Positives = 124/293 (42%), Gaps = 52/293 (17%)
Query: 1 MEEEAMNGDRTESD----WQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLM 56
+E+EA N R++ D +GL + + +L+ +K + +L+ ++ + + DQ +
Sbjct: 946 LEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTE 1005
Query: 57 ANQLRERHQ-------SLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEI 109
Q R Q SL+++ ++L S ++ A+L+QL + +N+ L E +
Sbjct: 1006 LMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQL----ESQNQLLQERL 1061
Query: 110 KELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEH 169
+ ++ +Q N+ L + + + + ED Q + K+Q+
Sbjct: 1062 QAEEREKTVLQSTNRKLERKVKELSI-------------QIEDERQHVNDQKDQLSLRVK 1108
Query: 170 DLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQ 229
L+ VDE ++ E + K +R +E + + N LQ R+K
Sbjct: 1109 ALKRQVDEAEEEIERLDGLRKKAQREVEEQHEV-----------------NEQLQARIKS 1151
Query: 230 LHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDH 282
L E+ + K++ + ++AL K +G SS V + LL+E +
Sbjct: 1152 L-EKDSWRKASRSAAESAL------KNEGLSSDEEFDSVYDPSSIASLLTESN 1197
Score = 42.7 bits (99), Expect = 8e-04
Identities = 64/269 (23%), Positives = 117/269 (43%), Gaps = 38/269 (14%)
Query: 27 RKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKR 86
R+LE + L +L E D ++ +Q + L++ Q ++ + + + +
Sbjct: 660 RELEKQ---LAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQ 716
Query: 87 KQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQG------------DNKLLRMTIAKQR 134
++A + LR++Q+ N I L+Q+L E +G +KL R+ KQ+
Sbjct: 717 RRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQ 776
Query: 135 LGDEAIGVRHFAAHEREDLVQQLERAKE-QIESLEHDLQASVDELQDVK---EERSSYQD 190
L +EA+ A+ E E + +RA E ++E + L E Q + EE ++
Sbjct: 777 L-EEALN----ASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQRE 831
Query: 191 KVERLNQELNHILSGHENRIID--VDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNAL 248
+ R EL + R++D VD L E + E KQ ++ L++ + YK
Sbjct: 832 VLRRGKAELE-----EQKRLLDRTVDRLNKELEKIGEDSKQALQQ---LQAQLEDYKEKA 883
Query: 249 ERR-KNSKGQGK---SSSSALTGVLSAKQ 273
R +++ Q K S + +G LS Q
Sbjct: 884 RREVADAQRQAKDWASEAEKTSGGLSRLQ 912
>gi|4504063 golgin 97 [Homo sapiens]
Length = 767
Score = 59.3 bits (142), Expect = 8e-09
Identities = 71/313 (22%), Positives = 131/313 (41%), Gaps = 29/313 (9%)
Query: 10 RTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYK-LMANQLRERHQSLK 68
R + +W + + K L ++ + + S L + E D+ + +L + L
Sbjct: 130 RKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLL 189
Query: 69 KKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRM 128
KK L + L R+ + + L +S + L ++++ELQ+
Sbjct: 190 KKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYS----------- 238
Query: 129 TIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSY 188
T+ +QR D I + A + L Q+ + + I+ L DLQ E Q+ ++ +
Sbjct: 239 TLEEQR--DHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHL 296
Query: 189 QDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNAL 248
Q+KV L + L LSG E+ V L E ++ L+ +++ +S+ AK N L
Sbjct: 297 QEKVASLEKRLEQNLSGEEH----VQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTL 352
Query: 249 ERRKNSKGQGKSSS----SALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALL 304
E R Q +S G+++A++ Q + E L A Q S ++ A AL
Sbjct: 353 ETRVRELEQTLQASEEQLQQSKGIVAAQETQ--IQE-----LAAANQESSHVQQQALALE 405
Query: 305 ETIHEKNMVIQHQ 317
+ E+ ++ Q
Sbjct: 406 QQFLERTQALEAQ 418
Score = 50.1 bits (118), Expect = 5e-06
Identities = 58/246 (23%), Positives = 99/246 (40%), Gaps = 20/246 (8%)
Query: 103 KHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKE 162
K + EE Q+ G + + + ++A D + REDL QL R E
Sbjct: 7 KKIAEETAVAQRPGGATRIPRSVSKESVASMG-ADSGDDFASDGSSSREDLSSQLLRRNE 65
Query: 163 QIESLE---HDLQASVDELQDVKEE----RSSYQDKVERLNQELNHILSGHENRIID--V 213
QI LE D V LQ +KE+ +QD R QE N + ++ +
Sbjct: 66 QIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLA 125
Query: 214 DALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQ 273
AL +++ E++ QL +E N+L + + + KN + + Q + L G Q
Sbjct: 126 LALARKDQEWSEKMDQLEKEKNILTAQLQEMKN----QSMNLFQRRDEMDELEGF----Q 177
Query: 274 VQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEK 333
Q+L H L +S+ ++ A + + + Q + L ++ EL++
Sbjct: 178 QQELSKIKH--MLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQR 235
Query: 334 KLRTLE 339
TLE
Sbjct: 236 HYSTLE 241
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 58.9 bits (141), Expect = 1e-08
Identities = 72/348 (20%), Positives = 151/348 (43%), Gaps = 45/348 (12%)
Query: 1 MEEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILS-KELDTCQQERDQYKLMANQ 59
+E E + ++ + Q L + + K +LE E L S +++ +QE + +
Sbjct: 510 LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSS 569
Query: 60 LRERHQSLKKKYRELIDGDPSLPPEKRKQAN--LAQL------LRDSQDRNKHLGEEIKE 111
LR+R Q + + I+ + + E K+ + L+++ ++ + K GE +E
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629
Query: 112 LQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDL 171
L+ L ++ +N+LL+ I ++ E I A E+E+ +LER +++
Sbjct: 630 LENELHHLEKENELLQKKITNLKITCEKI-----EALEQEN--SELERENRKLKKTLDSF 682
Query: 172 QASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLH 231
+ +L+ +++E S ++ N EL + + + + L +EN+ L+ +QL
Sbjct: 683 KNLTFQLESLEKENSQLDEE----NLELRRNVESLKCASMKMAQLQLENKELESEKEQLK 738
Query: 232 EEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQ 291
+ + LLK++ K + + + + L S K++Q L SE
Sbjct: 739 KGLELLKASFKKTERLEVSYQGLDIENQRLQKTLEN--SNKKIQQLESE----------- 785
Query: 292 SISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLE 339
L+ + +N +Q + KI R+ +LEK+ ++LE
Sbjct: 786 ------------LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLE 821
Score = 50.1 bits (118), Expect = 5e-06
Identities = 81/392 (20%), Positives = 155/392 (39%), Gaps = 88/392 (22%)
Query: 10 RTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSL-- 67
RTES Q L E K K+ ++ L +++L C+QE +Q ++ +L++ + +L
Sbjct: 242 RTESR-QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 68 ----KKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDN 123
+ YR+ +D R++A L R K +I+ + R+ E++ DN
Sbjct: 301 DARSARMYRDELDA-------LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDN 353
Query: 124 KLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVD------- 176
++L T K L D+ G R R D + +LE+ Q+++ HD++ D
Sbjct: 354 QVLLET--KTMLEDQLEGTR-----ARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIE 406
Query: 177 -------------------------ELQ------------------DVKEERSSYQDKVE 193
EL+ +V E SS K+E
Sbjct: 407 ELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466
Query: 194 RLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKN 253
NQ L + + V+ + +++ ++L ++V +L++ I + K +L+ +N
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526
Query: 254 SKGQGKSSSSALTGVL------SAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETI 307
+ L + S +Q++ L E+ + Q++S L+ + E
Sbjct: 527 LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN-----QTVSSLRQRSQISAEA- 580
Query: 308 HEKNMVIQHQRQTNKILGNRVAELEKKLRTLE 339
++ + NKIL + E KL +E
Sbjct: 581 -----RVKDIEKENKILHESIKETSSKLSKIE 607
Score = 43.9 bits (102), Expect = 4e-04
Identities = 51/255 (20%), Positives = 107/255 (41%), Gaps = 31/255 (12%)
Query: 27 RKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLK---KKYRELIDGDPSLPP 83
RKL+ ++ L+ +L++ ++E Q +LR +SLK K +L + L
Sbjct: 673 RKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELES 732
Query: 84 EKRKQANLAQLLRDSQDRNKHL---------------------GEEIKELQQRLGEVQGD 122
EK + +LL+ S + + L ++I++L+ L +++ +
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME 792
Query: 123 NKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVK 182
N+ L+ + + ++ + + E QLE+ K+Q+E L+ +
Sbjct: 793 NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL 852
Query: 183 EERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQER-------LKQLHEEVN 235
EE + +E+ N+ L+ + ++ + + L EN+ L +R L L E++
Sbjct: 853 EENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV 912
Query: 236 LLKSNIAKYKNALER 250
K + N LE+
Sbjct: 913 SEKLKTQQMNNDLEK 927
Score = 43.5 bits (101), Expect = 5e-04
Identities = 68/322 (21%), Positives = 136/322 (42%), Gaps = 40/322 (12%)
Query: 29 LESKKEALLILSKELDTCQQERDQYKLMANQ-----LRERHQSLKKKYRELIDGDPSLPP 83
L+++K+AL K+L+T Q Q +++A Q L+E++ +L+ + +L + +L
Sbjct: 1058 LQAEKQALKTQLKQLET-QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNS 1116
Query: 84 EKRKQANL-AQLLRDS---QDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEA 139
+ N AQLL ++ N+ + +E ++L+ + D++ L + +Q
Sbjct: 1117 QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQ------ 1170
Query: 140 IGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQEL 199
A E E L+ + K ++LE + + D + +++ +D + L E
Sbjct: 1171 -------ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQ 1223
Query: 200 NHIL---SGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKG 256
+L HE + LC EN L QL +E +L+++ K+ L K +
Sbjct: 1224 EKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT 1283
Query: 257 QGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQH 316
+ ++ S L +Q Q L T +++ L + L + E+N +
Sbjct: 1284 RLEAEFSKL-----KEQYQ---------QLDITSTKLNNQCELLSQLKGNLEEENRHLLD 1329
Query: 317 QRQTNKILGNRVAELEKKLRTL 338
Q QT + + E + + L
Sbjct: 1330 QIQTLMLQNRTLLEQNMESKDL 1351
Score = 39.3 bits (90), Expect = 0.009
Identities = 40/231 (17%), Positives = 107/231 (46%), Gaps = 10/231 (4%)
Query: 26 KRKLESKKEALLILSKELDTC-QQERDQYKLMANQ---LRERHQSLKKKYRELIDGDPSL 81
+ L+S ++L+ ++L+ +++ +Y+ + ++ L+ H++L+ ++R+L D L
Sbjct: 1146 REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQL 1205
Query: 82 PPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIG 141
+K + +L ++L+ Q++ + + + ++ G+N L T ++ E +
Sbjct: 1206 LKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQ 1265
Query: 142 VRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNH 201
H ++L L +K + LE + ++ Q + + ++ E L+Q +
Sbjct: 1266 TDH------KNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGN 1319
Query: 202 ILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRK 252
+ + + + + L ++NR L E+ + + ++ + N L R+K
Sbjct: 1320 LEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQK 1370
Score = 31.6 bits (70), Expect = 1.9
Identities = 73/370 (19%), Positives = 141/370 (38%), Gaps = 105/370 (28%)
Query: 62 ERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQ------- 114
+R +S + EL D + +++ + L D + + + E+K LQQ
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 115 --------------------------------------------RLGEVQGDNKLLRMTI 130
R+ E++ DN++L T
Sbjct: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET- 359
Query: 131 AKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVD----ELQDVKEERS 186
K L D+ G R R D + +LE+ Q+++ HD++ D +++++ EE
Sbjct: 360 -KTMLEDQLEGTR-----ARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM 413
Query: 187 SYQ-------DKVERLNQELNHILS------------GHE------NRIIDVDALCMENR 221
+ + D+ L EL I GHE +R++ ++ MEN+
Sbjct: 414 TLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE---MENQ 470
Query: 222 YLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQ-------- 273
L + +++L V+ ++ N +K L+ K ++ K ++ KQ
Sbjct: 471 SLTKTVEELRTTVDSVEGNASK---ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 274 VQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEK-NMVIQHQRQTNKILGN-RVAEL 331
+DL+ E L T +++ + +LE +E N + RQ ++I RV ++
Sbjct: 528 SKDLMKEK--AQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDI 585
Query: 332 EKKLRTLEVS 341
EK+ + L S
Sbjct: 586 EKENKILHES 595
Score = 31.2 bits (69), Expect = 2.5
Identities = 52/260 (20%), Positives = 106/260 (40%), Gaps = 29/260 (11%)
Query: 26 KRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEK 85
K +L+ E L K+ + + + +L++ ++ KK ++L L E
Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
Query: 86 RKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLL---------RMTIAKQRLG 136
+ + L+ S R + L +E K L+Q +++ D K L + I L
Sbjct: 794 QTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLE 853
Query: 137 DEAIGVRHFAAHE----------REDLVQQLERAKEQIESLEH---DLQASVDELQDVKE 183
+ + + + +E V+ E KE E ++ D++ V +D+
Sbjct: 854 ENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS 913
Query: 184 ERSSYQ---DKVERLNQELNHILSGHENRIIDVDALCMENRY--LQERLKQ-LHEEVNLL 237
E+ Q + +E+L EL I ++ R++ + ++RY L+ +L+ L + + +
Sbjct: 914 EKLKTQQMNNDLEKLTHELEKI-GLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIK 972
Query: 238 KSNIAKYKNALERRKNSKGQ 257
+ IA + LE N Q
Sbjct: 973 EEKIAALEARLEESTNYNQQ 992
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 58.9 bits (141), Expect = 1e-08
Identities = 72/348 (20%), Positives = 151/348 (43%), Gaps = 45/348 (12%)
Query: 1 MEEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILS-KELDTCQQERDQYKLMANQ 59
+E E + ++ + Q L + + K +LE E L S +++ +QE + +
Sbjct: 510 LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSS 569
Query: 60 LRERHQSLKKKYRELIDGDPSLPPEKRKQAN--LAQL------LRDSQDRNKHLGEEIKE 111
LR+R Q + + I+ + + E K+ + L+++ ++ + K GE +E
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629
Query: 112 LQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDL 171
L+ L ++ +N+LL+ I ++ E I A E+E+ +LER +++
Sbjct: 630 LENELHHLEKENELLQKKITNLKITCEKI-----EALEQEN--SELERENRKLKKTLDSF 682
Query: 172 QASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLH 231
+ +L+ +++E S ++ N EL + + + + L +EN+ L+ +QL
Sbjct: 683 KNLTFQLESLEKENSQLDEE----NLELRRNVESLKCASMKMAQLQLENKELESEKEQLK 738
Query: 232 EEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQ 291
+ + LLK++ K + + + + L S K++Q L SE
Sbjct: 739 KGLELLKASFKKTERLEVSYQGLDIENQRLQKTLEN--SNKKIQQLESE----------- 785
Query: 292 SISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLE 339
L+ + +N +Q + KI R+ +LEK+ ++LE
Sbjct: 786 ------------LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLE 821
Score = 50.1 bits (118), Expect = 5e-06
Identities = 81/392 (20%), Positives = 155/392 (39%), Gaps = 88/392 (22%)
Query: 10 RTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSL-- 67
RTES Q L E K K+ ++ L +++L C+QE +Q ++ +L++ + +L
Sbjct: 242 RTESR-QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 68 ----KKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDN 123
+ YR+ +D R++A L R K +I+ + R+ E++ DN
Sbjct: 301 DARSARMYRDELDA-------LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDN 353
Query: 124 KLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVD------- 176
++L T K L D+ G R R D + +LE+ Q+++ HD++ D
Sbjct: 354 QVLLET--KTMLEDQLEGTR-----ARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIE 406
Query: 177 -------------------------ELQ------------------DVKEERSSYQDKVE 193
EL+ +V E SS K+E
Sbjct: 407 ELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466
Query: 194 RLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKN 253
NQ L + + V+ + +++ ++L ++V +L++ I + K +L+ +N
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526
Query: 254 SKGQGKSSSSALTGVL------SAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETI 307
+ L + S +Q++ L E+ + Q++S L+ + E
Sbjct: 527 LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN-----QTVSSLRQRSQISAEA- 580
Query: 308 HEKNMVIQHQRQTNKILGNRVAELEKKLRTLE 339
++ + NKIL + E KL +E
Sbjct: 581 -----RVKDIEKENKILHESIKETSSKLSKIE 607
Score = 43.9 bits (102), Expect = 4e-04
Identities = 51/255 (20%), Positives = 107/255 (41%), Gaps = 31/255 (12%)
Query: 27 RKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLK---KKYRELIDGDPSLPP 83
RKL+ ++ L+ +L++ ++E Q +LR +SLK K +L + L
Sbjct: 673 RKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELES 732
Query: 84 EKRKQANLAQLLRDSQDRNKHL---------------------GEEIKELQQRLGEVQGD 122
EK + +LL+ S + + L ++I++L+ L +++ +
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME 792
Query: 123 NKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVK 182
N+ L+ + + ++ + + E QLE+ K+Q+E L+ +
Sbjct: 793 NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL 852
Query: 183 EERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQER-------LKQLHEEVN 235
EE + +E+ N+ L+ + ++ + + L EN+ L +R L L E++
Sbjct: 853 EENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV 912
Query: 236 LLKSNIAKYKNALER 250
K + N LE+
Sbjct: 913 SEKLKTQQMNNDLEK 927
Score = 43.5 bits (101), Expect = 5e-04
Identities = 68/322 (21%), Positives = 136/322 (42%), Gaps = 40/322 (12%)
Query: 29 LESKKEALLILSKELDTCQQERDQYKLMANQ-----LRERHQSLKKKYRELIDGDPSLPP 83
L+++K+AL K+L+T Q Q +++A Q L+E++ +L+ + +L + +L
Sbjct: 1057 LQAEKQALKTQLKQLET-QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNS 1115
Query: 84 EKRKQANL-AQLLRDS---QDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEA 139
+ N AQLL ++ N+ + +E ++L+ + D++ L + +Q
Sbjct: 1116 QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQ------ 1169
Query: 140 IGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQEL 199
A E E L+ + K ++LE + + D + +++ +D + L E
Sbjct: 1170 -------ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQ 1222
Query: 200 NHIL---SGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKG 256
+L HE + LC EN L QL +E +L+++ K+ L K +
Sbjct: 1223 EKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT 1282
Query: 257 QGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQH 316
+ ++ S L +Q Q L T +++ L + L + E+N +
Sbjct: 1283 RLEAEFSKL-----KEQYQ---------QLDITSTKLNNQCELLSQLKGNLEEENRHLLD 1328
Query: 317 QRQTNKILGNRVAELEKKLRTL 338
Q QT + + E + + L
Sbjct: 1329 QIQTLMLQNRTLLEQNMESKDL 1350
Score = 39.3 bits (90), Expect = 0.009
Identities = 40/231 (17%), Positives = 107/231 (46%), Gaps = 10/231 (4%)
Query: 26 KRKLESKKEALLILSKELDTC-QQERDQYKLMANQ---LRERHQSLKKKYRELIDGDPSL 81
+ L+S ++L+ ++L+ +++ +Y+ + ++ L+ H++L+ ++R+L D L
Sbjct: 1145 REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQL 1204
Query: 82 PPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIG 141
+K + +L ++L+ Q++ + + + ++ G+N L T ++ E +
Sbjct: 1205 LKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQ 1264
Query: 142 VRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNH 201
H ++L L +K + LE + ++ Q + + ++ E L+Q +
Sbjct: 1265 TDH------KNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGN 1318
Query: 202 ILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRK 252
+ + + + + L ++NR L E+ + + ++ + N L R+K
Sbjct: 1319 LEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQK 1369
Score = 32.7 bits (73), Expect = 0.84
Identities = 51/258 (19%), Positives = 101/258 (39%), Gaps = 26/258 (10%)
Query: 26 KRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEK 85
K +L+ E L K+ + + + +L++ ++ KK ++L L E
Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
Query: 86 RKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLL---------RMTIAKQRLG 136
+ + L+ S R + L +E K L+Q +++ D K L + I L
Sbjct: 794 QTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLE 853
Query: 137 DEAIGVRHFAAHE----------REDLVQQLERAKEQIESLEH---DLQASVDELQDVKE 183
+ + + + +E V+ E KE E ++ D++ V +D+
Sbjct: 854 ENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS 913
Query: 184 ERSSYQ---DKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQ-LHEEVNLLKS 239
E+ Q + +E+L EL I E + D + + L+ +L+ L + + + +
Sbjct: 914 EKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEE 973
Query: 240 NIAKYKNALERRKNSKGQ 257
IA + LE N Q
Sbjct: 974 KIAALEARLEESTNYNQQ 991
Score = 31.6 bits (70), Expect = 1.9
Identities = 73/370 (19%), Positives = 141/370 (38%), Gaps = 105/370 (28%)
Query: 62 ERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQ------- 114
+R +S + EL D + +++ + L D + + + E+K LQQ
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 115 --------------------------------------------RLGEVQGDNKLLRMTI 130
R+ E++ DN++L T
Sbjct: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET- 359
Query: 131 AKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVD----ELQDVKEERS 186
K L D+ G R R D + +LE+ Q+++ HD++ D +++++ EE
Sbjct: 360 -KTMLEDQLEGTR-----ARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM 413
Query: 187 SYQ-------DKVERLNQELNHILS------------GHE------NRIIDVDALCMENR 221
+ + D+ L EL I GHE +R++ ++ MEN+
Sbjct: 414 TLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE---MENQ 470
Query: 222 YLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQ-------- 273
L + +++L V+ ++ N +K L+ K ++ K ++ KQ
Sbjct: 471 SLTKTVEELRTTVDSVEGNASK---ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 274 VQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEK-NMVIQHQRQTNKILGN-RVAEL 331
+DL+ E L T +++ + +LE +E N + RQ ++I RV ++
Sbjct: 528 SKDLMKEK--AQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDI 585
Query: 332 EKKLRTLEVS 341
EK+ + L S
Sbjct: 586 EKENKILHES 595
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 58.5 bits (140), Expect = 1e-08
Identities = 94/417 (22%), Positives = 173/417 (41%), Gaps = 76/417 (18%)
Query: 25 CKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPE 84
CK + E +EA +L + + ++ ++ KLM +L Q KKK + L + L E
Sbjct: 458 CKLE-EDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEE 516
Query: 85 K---RKQANLAQLLRDS------------QDRNKHLG---EEIKELQQRLGE-VQGDNKL 125
R + +S QD NK + E + LQ +L + +Q +
Sbjct: 517 NENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHY 576
Query: 126 LRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKE---QIESLEHDLQASVDELQDVK 182
L+ TI K+ +A+ + A ++DL Q LE+ + +SL+ L + ++ ++
Sbjct: 577 LQTTITKEAY--DALSRKSAAC--QDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLE 632
Query: 183 EERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQER----LKQLHEEVNLLK 238
EE +Y++++++LN EL + H+ ++V A ++ L+E L+ + N LK
Sbjct: 633 EEIIAYEERMKKLNTELRKLRGFHQESELEVHAF---DKKLEEMSCQVLQWQKQHQNDLK 689
Query: 239 SNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSED-HGCSLP--ATPQSISD 295
AK + E ++ A ++LL +D C LP + P+
Sbjct: 690 MLAAKEEQLREFQEE----------------MAALKENLLEDDKEPCCLPQWSVPKDTCR 733
Query: 296 LKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILF 355
L ++ + + + Q+ N+ LGN++ E +V + L G KD
Sbjct: 734 LYRGNDQIMTNLEQ---WAKQQKVANEKLGNQLRE--------QVKYIAKLSGEKD---- 778
Query: 356 SDPTLPSGQRSRSPLLK--------FVEQPTENKADPKDGEAQKQEEDESCAAAEAL 404
+PT S + P V ENK K+ E +K + + + +AL
Sbjct: 779 REPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKAL 835
Score = 45.1 bits (105), Expect = 2e-04
Identities = 69/319 (21%), Positives = 137/319 (42%), Gaps = 33/319 (10%)
Query: 28 KLESKKEALLILSKELDTCQQERDQY-KLMANQLRERHQSLKKKYRELIDGDPSLPPEKR 86
+LE + L L K D QE+D+ + + +L + SL KK +EL + + E
Sbjct: 241 QLEFTETQKLTLKK--DKFLQEKDEMLQELEKKLTQVQNSLLKKEKEL-EKQQCMATELE 297
Query: 87 KQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFA 146
A+ + + K L E+++L+ L E + +L A+ + +EA A
Sbjct: 298 MTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCK--EEAA----LA 351
Query: 147 AHEREDLVQQLERA-------KEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQEL 199
ED ++L++ + I+ L+ +LQ E ++E++S + +VE L+ EL
Sbjct: 352 GCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLEL 411
Query: 200 NHILSGHENRIID-------VDALCMENRYLQERLKQLHEEVNLLKSNIAK--------Y 244
+ L EN + V M+ + +R+K H E +K + +
Sbjct: 412 SEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLL 471
Query: 245 KNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSI-SDLKSLATAL 303
++ E+ K SK K L + + +D +++ L +++ ++L+ +T L
Sbjct: 472 EDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQL 531
Query: 304 LETIHEKNMVIQHQRQTNK 322
++++ N Q + NK
Sbjct: 532 ESSLNKYNTSQQVIQDLNK 550
Score = 33.1 bits (74), Expect = 0.64
Identities = 55/263 (20%), Positives = 109/263 (41%), Gaps = 25/263 (9%)
Query: 151 EDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRI 210
+DL +LE EQ ++ D+ +L ++EE S++ ++ ++ L L +
Sbjct: 185 KDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEF 244
Query: 211 IDVDALCM-ENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVL 269
+ L + ++++LQE+ + L E L+ + + +N+L K K K A +
Sbjct: 245 TETQKLTLKKDKFLQEKDEMLQE----LEKKLTQVQNSL--LKKEKELEKQQCMATELEM 298
Query: 270 SAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVA 329
+ K+ + S++ C ++++ L +L E ++ + Q Q +
Sbjct: 299 TVKEAKQDKSKEAECKALQ-----AEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGC 353
Query: 330 ELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEA 389
LE R L+ GL DTI QR L Q + A+ +
Sbjct: 354 HLEDTQRKLQ-KGLLLDKQKADTI-------QELQRELQML-----QKESSMAEKEQTSN 400
Query: 390 QKQEEDESCAAAEALTAPEDAGR 412
+K+ E+ S +EAL E++ +
Sbjct: 401 RKRVEELSLELSEALRKLENSDK 423
Score = 31.6 bits (70), Expect = 1.9
Identities = 33/134 (24%), Positives = 57/134 (42%), Gaps = 11/134 (8%)
Query: 29 LESKKEALLI--LSKELDTCQQERDQYKLMAN------QLRERHQSLKKKYRELIDGDPS 80
LE KE + S DTC+ R ++M N Q + ++ L + RE +
Sbjct: 713 LEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAK 772
Query: 81 LPPEKRKQ---ANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGD 137
L EK ++ A+ R S + HL + LQQ +++ + + +M RL
Sbjct: 773 LSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCT 832
Query: 138 EAIGVRHFAAHERE 151
+A+G + +RE
Sbjct: 833 KALGPSRTESTQRE 846
Score = 30.4 bits (67), Expect = 4.2
Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 28/191 (14%)
Query: 155 QQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHIL------SGHEN 208
+QL A ++I SLE L D+ Q + +V+ L EL I+ G +
Sbjct: 17 EQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHS 76
Query: 209 RIIDVDALCM--ENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALT 266
++ + CM E++ Q+RL ++ ++V+ I + +N L + S+AL
Sbjct: 77 KVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKL-----------ACSNALV 125
Query: 267 GVLSAKQVQDLLSEDHGCSL-----PATPQSISDLKSLATALLETIHEKNMVIQHQRQTN 321
+ K + L ++ C+ P++ + D+K + L E +K+ H +
Sbjct: 126 -LEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQE---QKDSQCLHVEEYQ 181
Query: 322 KILGNRVAELE 332
++ + ELE
Sbjct: 182 NLVKDLRVELE 192
>gi|62243374 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 58.5 bits (140), Expect = 1e-08
Identities = 94/440 (21%), Positives = 186/440 (42%), Gaps = 50/440 (11%)
Query: 59 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANL---AQLLRDSQDRNKHLGEEIKELQQR 115
QL+ER ++K +E ++ + ++ Q NL ++ LR+ +D GE I L+ R
Sbjct: 112 QLQEREAGAEEKMQEQLERN------RQCQQNLDAASKRLREKEDSLAQAGETINALKGR 165
Query: 116 LGEVQ-----GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKE-------Q 163
+ E+Q + ++ R+ KQ L E + ++H E +Q+L+ ++E Q
Sbjct: 166 ISELQWSVMDQEMRVKRLESEKQEL-QEQLDLQHKKCQEANQKIQELQASQEARADHEQQ 224
Query: 164 IESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHIL--SGHENRIIDVDALCME-- 219
I+ LE L + VK +S ++ RL +EL + S H + + + L E
Sbjct: 225 IKDLEQKLSLQEQDAAIVKNMKSELV-RLPRLERELKQLREESAHLREMRETNGLLQEEL 283
Query: 220 ---NRYL--QERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQV 274
R L QE++++ + L + + ER + G + L+ + Q
Sbjct: 284 EGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQ 343
Query: 275 QDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKK 334
++L +D ++ ++ + + + L + + + + +R+T++ L R L+K+
Sbjct: 344 RELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARR---LQKR 400
Query: 335 --LRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQ 392
L T E G+ ++ G D+ L P R V++ + A+ + +Q
Sbjct: 401 VLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQAL 460
Query: 393 EEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIK 452
EE + E + +S A QS L S EE ++L ++ +
Sbjct: 461 EELGGQKQRADMLEMELKMLKSQSSSAEQS-------------FLFSREEADTLRLKVEE 507
Query: 453 LTKEQAAAELEEVRRESPIE 472
L E++ E E+ E+ +E
Sbjct: 508 LEGERSRLEEEKRMLEAQLE 527
Score = 41.2 bits (95), Expect = 0.002
Identities = 72/354 (20%), Positives = 146/354 (41%), Gaps = 71/354 (20%)
Query: 10 RTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQE-RDQYKLMANQL------RE 62
RT D V E + L+ K A+ ++ L+ +Q+ +++ + ++ QL RE
Sbjct: 329 RTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRE 388
Query: 63 RHQSLKKKYRELI-------DG--------DPSLPPEKRKQANLAQLLRDSQDRNKHLGE 107
H++L ++ ++ + DG D L P + L + +R+++D + +
Sbjct: 389 THEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSP-QLTRRMREAEDMVQKVHS 447
Query: 108 EIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQ-QLERAKEQIES 166
E++ +L + A + LG + +R D+++ +L+ K Q S
Sbjct: 448 HSAEMEAQLSQ------------ALEELGGQK---------QRADMLEMELKMLKSQSSS 486
Query: 167 LEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQER 226
E S +E ++ + + + RL +E + + E R + D Y Q R
Sbjct: 487 AEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGD-------YDQSR 539
Query: 227 LKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSL 286
K LH +N +++A+ +R + Q ++ L G+L A + + D +
Sbjct: 540 TKVLHMSLN--PTSVAR-----QRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAA 592
Query: 287 PATPQS--ISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTL 338
+ P S +++LK +E+ KN ++ QT ++ E K TL
Sbjct: 593 ASLPSSKEVAELKK----QVESAELKNQRLKEVFQT------KIQEFRKACYTL 636
Score = 39.7 bits (91), Expect = 0.007
Identities = 54/256 (21%), Positives = 111/256 (43%), Gaps = 18/256 (7%)
Query: 3 EEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQL-- 60
++ M R ES+ Q L + + +K + + + L + Q K + +L
Sbjct: 175 DQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSL 234
Query: 61 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQ 120
+E+ ++ K + + P L E ++ + LR+ ++ N L EE++ LQ++LG
Sbjct: 235 QEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGR-- 292
Query: 121 GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLE-RAKEQIESLEHDLQASVDELQ 179
+ ++ T+ L +E + + + ER D L R E + +LQ L+
Sbjct: 293 --QEKMQETLVGLELENERL-LAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALK 349
Query: 180 DVKEERSSYQDKVERLNQELNHILSGHENRIIDV-------DALCMENRYLQERLKQLHE 232
D +S +E+ Q+L L ++++ +AL R LQ+R+ L +
Sbjct: 350 DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALA---RRLQKRVLLLTK 406
Query: 233 EVNLLKSNIAKYKNAL 248
E + +++ + Y + L
Sbjct: 407 ERDGMRAILGSYDSEL 422
Score = 37.7 bits (86), Expect = 0.026
Identities = 43/191 (22%), Positives = 78/191 (40%), Gaps = 11/191 (5%)
Query: 156 QLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDA 215
QLE EQI S H +Q +++Q E S + +VE L + + +E +
Sbjct: 50 QLEERAEQIRSKSHLIQVEREKMQ---MELSHKRARVE-LERAASTSARNYEREVDRNQE 105
Query: 216 LCMENRYLQER-------LKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGV 268
L R LQER +++ E + N+ L +++S Q + +AL G
Sbjct: 106 LLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGR 165
Query: 269 LSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRV 328
+S Q + E L + Q + + L + ++K +Q ++ ++
Sbjct: 166 ISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQI 225
Query: 329 AELEKKLRTLE 339
+LE+KL E
Sbjct: 226 KDLEQKLSLQE 236
Score = 33.5 bits (75), Expect = 0.49
Identities = 44/200 (22%), Positives = 87/200 (43%), Gaps = 18/200 (9%)
Query: 4 EAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRER 63
E + G + +D L E + K + S +++ L +E DT + + ++ + ++L E
Sbjct: 461 EELGGQKQRADM--LEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEE 518
Query: 64 HQSLKKKY-RELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGD 122
+ L+ + R + GD ++ + L L + + L E+ +LQ ++G
Sbjct: 519 KRMLEAQLERRALQGDY----DQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRG- 573
Query: 123 NKLLRMTIAKQRLGD-----EAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDE 177
LLR A +R G EA ++ E +L +Q+E A+ + + L+ Q + E
Sbjct: 574 --LLR---AMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQE 628
Query: 178 LQDVKEERSSYQDKVERLNQ 197
+ + YQ + NQ
Sbjct: 629 FRKACYTLTGYQIDITTENQ 648
>gi|62243369 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 58.5 bits (140), Expect = 1e-08
Identities = 94/440 (21%), Positives = 186/440 (42%), Gaps = 50/440 (11%)
Query: 59 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANL---AQLLRDSQDRNKHLGEEIKELQQR 115
QL+ER ++K +E ++ + ++ Q NL ++ LR+ +D GE I L+ R
Sbjct: 112 QLQEREAGAEEKMQEQLERN------RQCQQNLDAASKRLREKEDSLAQAGETINALKGR 165
Query: 116 LGEVQ-----GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKE-------Q 163
+ E+Q + ++ R+ KQ L E + ++H E +Q+L+ ++E Q
Sbjct: 166 ISELQWSVMDQEMRVKRLESEKQEL-QEQLDLQHKKCQEANQKIQELQASQEARADHEQQ 224
Query: 164 IESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHIL--SGHENRIIDVDALCME-- 219
I+ LE L + VK +S ++ RL +EL + S H + + + L E
Sbjct: 225 IKDLEQKLSLQEQDAAIVKNMKSELV-RLPRLERELKQLREESAHLREMRETNGLLQEEL 283
Query: 220 ---NRYL--QERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQV 274
R L QE++++ + L + + ER + G + L+ + Q
Sbjct: 284 EGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQ 343
Query: 275 QDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKK 334
++L +D ++ ++ + + + L + + + + +R+T++ L R L+K+
Sbjct: 344 RELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARR---LQKR 400
Query: 335 --LRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQ 392
L T E G+ ++ G D+ L P R V++ + A+ + +Q
Sbjct: 401 VLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQAL 460
Query: 393 EEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIK 452
EE + E + +S A QS L S EE ++L ++ +
Sbjct: 461 EELGGQKQRADMLEMELKMLKSQSSSAEQS-------------FLFSREEADTLRLKVEE 507
Query: 453 LTKEQAAAELEEVRRESPIE 472
L E++ E E+ E+ +E
Sbjct: 508 LEGERSRLEEEKRMLEAQLE 527
Score = 41.2 bits (95), Expect = 0.002
Identities = 72/354 (20%), Positives = 146/354 (41%), Gaps = 71/354 (20%)
Query: 10 RTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQE-RDQYKLMANQL------RE 62
RT D V E + L+ K A+ ++ L+ +Q+ +++ + ++ QL RE
Sbjct: 329 RTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRE 388
Query: 63 RHQSLKKKYRELI-------DG--------DPSLPPEKRKQANLAQLLRDSQDRNKHLGE 107
H++L ++ ++ + DG D L P + L + +R+++D + +
Sbjct: 389 THEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSP-QLTRRMREAEDMVQKVHS 447
Query: 108 EIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQ-QLERAKEQIES 166
E++ +L + A + LG + +R D+++ +L+ K Q S
Sbjct: 448 HSAEMEAQLSQ------------ALEELGGQK---------QRADMLEMELKMLKSQSSS 486
Query: 167 LEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQER 226
E S +E ++ + + + RL +E + + E R + D Y Q R
Sbjct: 487 AEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGD-------YDQSR 539
Query: 227 LKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSL 286
K LH +N +++A+ +R + Q ++ L G+L A + + D +
Sbjct: 540 TKVLHMSLN--PTSVAR-----QRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAA 592
Query: 287 PATPQS--ISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTL 338
+ P S +++LK +E+ KN ++ QT ++ E K TL
Sbjct: 593 ASLPSSKEVAELKK----QVESAELKNQRLKEVFQT------KIQEFRKACYTL 636
Score = 39.7 bits (91), Expect = 0.007
Identities = 54/256 (21%), Positives = 111/256 (43%), Gaps = 18/256 (7%)
Query: 3 EEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQL-- 60
++ M R ES+ Q L + + +K + + + L + Q K + +L
Sbjct: 175 DQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSL 234
Query: 61 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQ 120
+E+ ++ K + + P L E ++ + LR+ ++ N L EE++ LQ++LG
Sbjct: 235 QEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGR-- 292
Query: 121 GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLE-RAKEQIESLEHDLQASVDELQ 179
+ ++ T+ L +E + + + ER D L R E + +LQ L+
Sbjct: 293 --QEKMQETLVGLELENERL-LAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALK 349
Query: 180 DVKEERSSYQDKVERLNQELNHILSGHENRIIDV-------DALCMENRYLQERLKQLHE 232
D +S +E+ Q+L L ++++ +AL R LQ+R+ L +
Sbjct: 350 DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALA---RRLQKRVLLLTK 406
Query: 233 EVNLLKSNIAKYKNAL 248
E + +++ + Y + L
Sbjct: 407 ERDGMRAILGSYDSEL 422
Score = 37.7 bits (86), Expect = 0.026
Identities = 43/191 (22%), Positives = 78/191 (40%), Gaps = 11/191 (5%)
Query: 156 QLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDA 215
QLE EQI S H +Q +++Q E S + +VE L + + +E +
Sbjct: 50 QLEERAEQIRSKSHLIQVEREKMQ---MELSHKRARVE-LERAASTSARNYEREVDRNQE 105
Query: 216 LCMENRYLQER-------LKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGV 268
L R LQER +++ E + N+ L +++S Q + +AL G
Sbjct: 106 LLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGR 165
Query: 269 LSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRV 328
+S Q + E L + Q + + L + ++K +Q ++ ++
Sbjct: 166 ISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQI 225
Query: 329 AELEKKLRTLE 339
+LE+KL E
Sbjct: 226 KDLEQKLSLQE 236
Score = 33.5 bits (75), Expect = 0.49
Identities = 44/200 (22%), Positives = 87/200 (43%), Gaps = 18/200 (9%)
Query: 4 EAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRER 63
E + G + +D L E + K + S +++ L +E DT + + ++ + ++L E
Sbjct: 461 EELGGQKQRADM--LEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEE 518
Query: 64 HQSLKKKY-RELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGD 122
+ L+ + R + GD ++ + L L + + L E+ +LQ ++G
Sbjct: 519 KRMLEAQLERRALQGDY----DQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRG- 573
Query: 123 NKLLRMTIAKQRLGD-----EAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDE 177
LLR A +R G EA ++ E +L +Q+E A+ + + L+ Q + E
Sbjct: 574 --LLR---AMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQE 628
Query: 178 LQDVKEERSSYQDKVERLNQ 197
+ + YQ + NQ
Sbjct: 629 FRKACYTLTGYQIDITTENQ 648
>gi|62243332 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 58.5 bits (140), Expect = 1e-08
Identities = 94/440 (21%), Positives = 186/440 (42%), Gaps = 50/440 (11%)
Query: 59 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANL---AQLLRDSQDRNKHLGEEIKELQQR 115
QL+ER ++K +E ++ + ++ Q NL ++ LR+ +D GE I L+ R
Sbjct: 112 QLQEREAGAEEKMQEQLERN------RQCQQNLDAASKRLREKEDSLAQAGETINALKGR 165
Query: 116 LGEVQ-----GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKE-------Q 163
+ E+Q + ++ R+ KQ L E + ++H E +Q+L+ ++E Q
Sbjct: 166 ISELQWSVMDQEMRVKRLESEKQEL-QEQLDLQHKKCQEANQKIQELQASQEARADHEQQ 224
Query: 164 IESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHIL--SGHENRIIDVDALCME-- 219
I+ LE L + VK +S ++ RL +EL + S H + + + L E
Sbjct: 225 IKDLEQKLSLQEQDAAIVKNMKSELV-RLPRLERELKQLREESAHLREMRETNGLLQEEL 283
Query: 220 ---NRYL--QERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQV 274
R L QE++++ + L + + ER + G + L+ + Q
Sbjct: 284 EGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQ 343
Query: 275 QDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKK 334
++L +D ++ ++ + + + L + + + + +R+T++ L R L+K+
Sbjct: 344 RELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARR---LQKR 400
Query: 335 --LRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQ 392
L T E G+ ++ G D+ L P R V++ + A+ + +Q
Sbjct: 401 VLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQAL 460
Query: 393 EEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIK 452
EE + E + +S A QS L S EE ++L ++ +
Sbjct: 461 EELGGQKQRADMLEMELKMLKSQSSSAEQS-------------FLFSREEADTLRLKVEE 507
Query: 453 LTKEQAAAELEEVRRESPIE 472
L E++ E E+ E+ +E
Sbjct: 508 LEGERSRLEEEKRMLEAQLE 527
Score = 41.2 bits (95), Expect = 0.002
Identities = 72/354 (20%), Positives = 146/354 (41%), Gaps = 71/354 (20%)
Query: 10 RTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQE-RDQYKLMANQL------RE 62
RT D V E + L+ K A+ ++ L+ +Q+ +++ + ++ QL RE
Sbjct: 329 RTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRE 388
Query: 63 RHQSLKKKYRELI-------DG--------DPSLPPEKRKQANLAQLLRDSQDRNKHLGE 107
H++L ++ ++ + DG D L P + L + +R+++D + +
Sbjct: 389 THEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSP-QLTRRMREAEDMVQKVHS 447
Query: 108 EIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQ-QLERAKEQIES 166
E++ +L + A + LG + +R D+++ +L+ K Q S
Sbjct: 448 HSAEMEAQLSQ------------ALEELGGQK---------QRADMLEMELKMLKSQSSS 486
Query: 167 LEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQER 226
E S +E ++ + + + RL +E + + E R + D Y Q R
Sbjct: 487 AEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGD-------YDQSR 539
Query: 227 LKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSL 286
K LH +N +++A+ +R + Q ++ L G+L A + + D +
Sbjct: 540 TKVLHMSLN--PTSVAR-----QRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAA 592
Query: 287 PATPQS--ISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTL 338
+ P S +++LK +E+ KN ++ QT ++ E K TL
Sbjct: 593 ASLPSSKEVAELKK----QVESAELKNQRLKEVFQT------KIQEFRKACYTL 636
Score = 39.7 bits (91), Expect = 0.007
Identities = 54/256 (21%), Positives = 111/256 (43%), Gaps = 18/256 (7%)
Query: 3 EEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQL-- 60
++ M R ES+ Q L + + +K + + + L + Q K + +L
Sbjct: 175 DQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSL 234
Query: 61 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQ 120
+E+ ++ K + + P L E ++ + LR+ ++ N L EE++ LQ++LG
Sbjct: 235 QEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGR-- 292
Query: 121 GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLE-RAKEQIESLEHDLQASVDELQ 179
+ ++ T+ L +E + + + ER D L R E + +LQ L+
Sbjct: 293 --QEKMQETLVGLELENERL-LAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALK 349
Query: 180 DVKEERSSYQDKVERLNQELNHILSGHENRIIDV-------DALCMENRYLQERLKQLHE 232
D +S +E+ Q+L L ++++ +AL R LQ+R+ L +
Sbjct: 350 DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALA---RRLQKRVLLLTK 406
Query: 233 EVNLLKSNIAKYKNAL 248
E + +++ + Y + L
Sbjct: 407 ERDGMRAILGSYDSEL 422
Score = 37.7 bits (86), Expect = 0.026
Identities = 43/191 (22%), Positives = 78/191 (40%), Gaps = 11/191 (5%)
Query: 156 QLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDA 215
QLE EQI S H +Q +++Q E S + +VE L + + +E +
Sbjct: 50 QLEERAEQIRSKSHLIQVEREKMQ---MELSHKRARVE-LERAASTSARNYEREVDRNQE 105
Query: 216 LCMENRYLQER-------LKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGV 268
L R LQER +++ E + N+ L +++S Q + +AL G
Sbjct: 106 LLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGR 165
Query: 269 LSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRV 328
+S Q + E L + Q + + L + ++K +Q ++ ++
Sbjct: 166 ISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQI 225
Query: 329 AELEKKLRTLE 339
+LE+KL E
Sbjct: 226 KDLEQKLSLQE 236
Score = 33.5 bits (75), Expect = 0.49
Identities = 44/200 (22%), Positives = 87/200 (43%), Gaps = 18/200 (9%)
Query: 4 EAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRER 63
E + G + +D L E + K + S +++ L +E DT + + ++ + ++L E
Sbjct: 461 EELGGQKQRADM--LEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEE 518
Query: 64 HQSLKKKY-RELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGD 122
+ L+ + R + GD ++ + L L + + L E+ +LQ ++G
Sbjct: 519 KRMLEAQLERRALQGDY----DQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRG- 573
Query: 123 NKLLRMTIAKQRLGD-----EAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDE 177
LLR A +R G EA ++ E +L +Q+E A+ + + L+ Q + E
Sbjct: 574 --LLR---AMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQE 628
Query: 178 LQDVKEERSSYQDKVERLNQ 197
+ + YQ + NQ
Sbjct: 629 FRKACYTLTGYQIDITTENQ 648
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 58.2 bits (139), Expect = 2e-08
Identities = 99/434 (22%), Positives = 174/434 (40%), Gaps = 67/434 (15%)
Query: 9 DRTESDWQGLVSEYLVCKRKLESKKEALLIL-------SKELDTCQQERDQYKLMANQLR 61
+ ES Q L E + + KL+ +E +IL +KE + ++ +
Sbjct: 953 EEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEE 1012
Query: 62 ERHQSL---KKKYRELI-DGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLG 117
E+ +SL K K+ +I D + L E++++ L + R + + L ++I ELQ ++
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIA 1072
Query: 118 EV--QGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIES--------- 166
E+ Q K + A R+ +EA ++ A + +L Q+ +E +ES
Sbjct: 1073 ELKMQLAKKEEELQAALARVEEEA-AQKNMALKKIRELESQISELQEDLESERASRNKAE 1131
Query: 167 -----LEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENR 221
L +L+A EL+D + ++ Q+ + QE+N + E +A E R
Sbjct: 1132 KQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMR 1191
Query: 222 YLQ----ERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDL 277
E L + E+ +K+N+ K K LE N +G+ A +V+ L
Sbjct: 1192 QKHSQAVEELAEQLEQTKRVKANLEKAKQTLE---NERGE------------LANEVKVL 1236
Query: 278 LSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRT 337
L Q D + + + E + + L ++V +L+ +L
Sbjct: 1237 L------------QGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELD- 1283
Query: 338 LEVSGLWSLPGGKDTILFSD-PTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDE 396
V+GL S K + L D L S + LL+ EN+ KQ EDE
Sbjct: 1284 -NVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ-----EENRQKLSLSTKLKQVEDE 1337
Query: 397 SCAAAEALTAPEDA 410
+ E L E+A
Sbjct: 1338 KNSFREQLEEEEEA 1351
Score = 52.8 bits (125), Expect = 8e-07
Identities = 97/458 (21%), Positives = 189/458 (41%), Gaps = 72/458 (15%)
Query: 94 LLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFA------A 147
LL+ S+ + + +E + ++ R ++ +N+L M + +L E + ++
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
Query: 148 HEREDLVQQLERAKEQIESLEHDLQASVDE----LQDVKEERSSYQDKVERLNQELNHIL 203
E E+L +L K+++E + HDL+A V+E Q ++ E+ Q ++ L ++L
Sbjct: 897 AEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEE 956
Query: 204 SGHENRIID-------VDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNAL---ERRKN 253
S + ++ + L E L+++ +L +E LL+ IA++ L E +
Sbjct: 957 SARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSK 1016
Query: 254 SKGQGKSSSSALTGVL------SAKQVQDLL---------SEDHGCSLPATPQSISDLK- 297
S + K+ A+ L KQ Q+L S D + I++LK
Sbjct: 1017 SLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM 1076
Query: 298 -------SLATALL---ETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVS------ 341
L AL E +KNM ++ R+ L ++++EL++ L + S
Sbjct: 1077 QLAKKEEELQAALARVEEEAAQKNMALKKIRE----LESQISELQEDLESERASRNKAEK 1132
Query: 342 -------GLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEE 394
L +L + L S + R + +++ E +A + + Q+ +
Sbjct: 1133 QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQ 1192
Query: 395 DESCAAAEALTAPEDAGRPAVN-SPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKL 453
S A E E R N A Q+ N+ +L +E +V G+ +
Sbjct: 1193 KHSQAVEELAEQLEQTKRVKANLEKAKQTLENE-------RGELANEVKVLLQGKGDSEH 1245
Query: 454 TKEQAAAELEEVRRESPIEGQRSETGPAPPGLAIQGEL 491
+++ A+L+E++ + EG+R T A +Q EL
Sbjct: 1246 KRKKVEAQLQELQVKFN-EGERVRTELADKVTKLQVEL 1282
Score = 52.8 bits (125), Expect = 8e-07
Identities = 61/291 (20%), Positives = 125/291 (42%), Gaps = 31/291 (10%)
Query: 27 RKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKR 86
RKL+++ + + +ELD + R++ + Q +E + LK E+I L +R
Sbjct: 1641 RKLQAQMKDCM---RELDDTRASREE---ILAQAKENEKKLKSMEAEMIQLQEELAAAER 1694
Query: 87 KQANLAQLLRD---------------SQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIA 131
+ AQ RD + + + L I +L++ L E QG+ +L+ +
Sbjct: 1695 AKRQ-AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK 1753
Query: 132 KQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDK 191
K L + I + Q+ E A++Q+E +L+ + E++ +S Y+
Sbjct: 1754 KANLQIDQINTD---LNLERSHAQKNENARQQLERQNKELKVKLQEMEGTV--KSKYKAS 1808
Query: 192 VERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKN----A 247
+ L ++ + +N + A C + R +++LK + +V+ + N +YK+ A
Sbjct: 1809 ITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKA 1868
Query: 248 LERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKS 298
R K K Q + + ++++ ED + A + +S LK+
Sbjct: 1869 STRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKN 1919
Score = 51.6 bits (122), Expect = 2e-06
Identities = 74/364 (20%), Positives = 152/364 (41%), Gaps = 52/364 (14%)
Query: 10 RTESDWQGLVS---EYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQS 66
+ + D +GL E + KLE K L +ELD + D + A L ++
Sbjct: 1389 KLQKDLEGLSQRHEEKVAAYDKLEKTKTRL---QQELDDLLVDLDHQRQSACNLEKK--- 1442
Query: 67 LKKKYRELIDGDPSLPPEKRKQANLAQL-LRDSQDRNKHLGEEIKELQQRLGEVQGDNKL 125
+KK+ +L+ + ++ + ++ + A+ R+ + + L ++E ++ E++ NK
Sbjct: 1443 -QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQ 1501
Query: 126 LRMTIAKQRLGDEAIGVR-HFAAHEREDLVQQLERAKEQIESLEHDLQASVD-------- 176
R + + +G H + L QQ+E K Q+E LE +LQA+ D
Sbjct: 1502 FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVN 1561
Query: 177 ----------ELQDVKEERSSYQDKVERLNQELNHILSGHE---------NRIIDVDALC 217
+LQ E+ + ++ R +E+ L + +++D
Sbjct: 1562 LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKD 1621
Query: 218 ME------NRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSA 271
+E N+ E +KQL + +K + + + R+ Q K + L + A
Sbjct: 1622 LEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKS-MEA 1680
Query: 272 KQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAEL 331
+ +Q L E+ + A Q+ + LA + + + + ++ +R+ L R+A+L
Sbjct: 1681 EMIQ--LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRR----LEARIAQL 1734
Query: 332 EKKL 335
E++L
Sbjct: 1735 EEEL 1738
Score = 49.3 bits (116), Expect = 9e-06
Identities = 94/456 (20%), Positives = 181/456 (39%), Gaps = 66/456 (14%)
Query: 39 LSKELDTCQQERDQYKLMANQLRERHQSLKKKYR----ELIDGDPSLPPEKRKQANLAQL 94
L+ ++ Q E D + +Q + L K + +L D L E R++ +L+
Sbjct: 1271 LADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTK 1330
Query: 95 LRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLV 154
L+ +D E+++E ++ ++ L +A + + ED V
Sbjct: 1331 LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMK-------------KKMEDSV 1377
Query: 155 QQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVE----RLNQELNHILSGHENRI 210
LE A+E L+ DL+ L EE+ + DK+E RL QEL+ +L
Sbjct: 1378 GCLETAEEVKRKLQKDLEG----LSQRHEEKVAAYDKLEKTKTRLQQELDDLL------- 1426
Query: 211 IDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLS 270
+D+D L+++ K+ + + K+ AKY +R + + ++ + +L L
Sbjct: 1427 VDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALE 1486
Query: 271 AKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAE 330
Q E + DL S + +++HE + Q + + ++ E
Sbjct: 1487 EAMEQKAELERLNKQFRT---EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEE 1543
Query: 331 LEKKLRTLEVSGL---WSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDG 387
LE +L+ E + L +L K F ++S + V Q E +A+ +D
Sbjct: 1544 LEDELQATEDAKLRLEVNLQAMK--AQFERDLQGRDEQSEEKKKQLVRQVREMEAELED- 1600
Query: 388 EAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQL---------- 437
++++ + AA + L ++S AN++R K Q+
Sbjct: 1601 --ERKQRSMAVAARKKLEMDLKDLEAHIDS-ANKNRDEAIKQLRKLQAQMKDCMRELDDT 1657
Query: 438 ------------PSEEEVNSLGREIIKLTKEQAAAE 461
+E+++ S+ E+I+L +E AAAE
Sbjct: 1658 RASREEILAQAKENEKKLKSMEAEMIQLQEELAAAE 1693
Score = 33.9 bits (76), Expect = 0.38
Identities = 38/159 (23%), Positives = 65/159 (40%), Gaps = 24/159 (15%)
Query: 47 QQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLG 106
QQ Q K + +L+E ++K KY+ I +A +AQL + L
Sbjct: 1781 QQLERQNKELKVKLQEMEGTVKSKYKASITA---------LEAKIAQL-------EEQLD 1824
Query: 107 EEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHF------AAHEREDLVQQLERA 160
E KE Q +V+ K L+ + + + DE + A+ + L +QLE A
Sbjct: 1825 NETKERQAACKQVRRTEKKLKDVLLQ--VDDERRNAEQYKDQADKASTRLKQLKRQLEEA 1882
Query: 161 KEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQEL 199
+E+ + + EL+D E + +V L +L
Sbjct: 1883 EEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 57.8 bits (138), Expect = 2e-08
Identities = 75/366 (20%), Positives = 162/366 (44%), Gaps = 34/366 (9%)
Query: 1 MEEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQL 60
++E N +S GL+ E K+KLE K E + L ++ Q+++Q +Q+
Sbjct: 2489 LDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI----QDQEQLVSKLSQV 2544
Query: 61 RERHQSLKKKYREL----IDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRL 116
HQ K++ EL ++ + + + K A+L L Q K+L E++ ++
Sbjct: 2545 EGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELE--LTKM 2602
Query: 117 GEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVD 176
++ K+ +MT + L E + A +E+L + R +++ L ++++S D
Sbjct: 2603 DKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKD 2662
Query: 177 ELQDVKEERSS--------YQDKVE---RLNQEL-NHILSGHENRIIDVDALCMENRYLQ 224
+L+++ E S ++D+VE ++ +E+ + L HE L N+ +
Sbjct: 2663 QLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYE 2722
Query: 225 ERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVL---------SAKQVQ 275
++ E++ + ++ K ++ K+SK + +S A T +L + K V
Sbjct: 2723 VEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVN 2782
Query: 276 DLLSEDHGC--SLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEK 333
L E+ + +S L+ L + + + Q +++T ++ +V EL
Sbjct: 2783 QLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQL-QAAQEKQKTGTVMDTKVDELTT 2841
Query: 334 KLRTLE 339
+++ L+
Sbjct: 2842 EIKELK 2847
Score = 56.6 bits (135), Expect = 5e-08
Identities = 97/500 (19%), Positives = 211/500 (42%), Gaps = 55/500 (11%)
Query: 12 ESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYK--------------LMA 57
E+D + + +E L ++ E+K++ ++ L +EL ER+Q + ++
Sbjct: 1922 EADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLS 1981
Query: 58 NQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLG 117
+++E+ Q L+ E + E +++ L Q L S D ++ L ++ LQ++L
Sbjct: 1982 EKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTL--SSDVSELLKDK-THLQEKLQ 2038
Query: 118 EVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDE 177
++ D++ L +T K L ++ + E+E LV++ E + ++ +++
Sbjct: 2039 SLEKDSQALSLT--KCELENQIAQLN----KEKELLVKESESLQARLSESDYEKLNVSKA 2092
Query: 178 LQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLL 237
L+ E+ + ++ +E++ + G E + ++A + ++ E+LK+ E + L
Sbjct: 2093 LEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSL 2152
Query: 238 KSNIAKYKNALER-----------RKNSKGQGKSSSSALTGVLSAKQVQDL-------LS 279
K + + L+ +NSK + ++ + + + + +V +L
Sbjct: 2153 KDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEK 2212
Query: 280 EDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLE 339
E+ + +S+L L ++ + EK Q + Q + V L+ +L+ L
Sbjct: 2213 ENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE---QAEIQIKEESKTAVEMLQNQLKELN 2269
Query: 340 VSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQ-PTENKADPKDGEAQKQEEDESC 398
+ +L G ++ + ++ +L L +E+ +AD K Q+ ES
Sbjct: 2270 -EAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESE 2328
Query: 399 AAAEALTA-PEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQ 457
A+ L E+ R + NQ H +L S+ EV +L +I +T+
Sbjct: 2329 HHADLLKGRVENLERELEIARTNQE--------HAALEAENSKGEVETLKAKIEGMTQSL 2380
Query: 458 AAAELEEVRRESPIEGQRSE 477
EL+ V S E +E
Sbjct: 2381 RGLELDVVTIRSEKENLTNE 2400
Score = 52.4 bits (124), Expect = 1e-06
Identities = 86/379 (22%), Positives = 169/379 (44%), Gaps = 32/379 (8%)
Query: 33 KEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKY----RELIDGDPSLPPEKRKQ 88
+E + + LD +E Q + +LR R ++ +KK ++L + + K +
Sbjct: 2279 QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRV 2338
Query: 89 ANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQG-DNKLLRMTIAKQRLGDEAIGVRHFAA 147
NL + L ++ +H E + + GEV+ K+ MT + + L + + +R
Sbjct: 2339 ENLERELEIARTNQEHAALEAENSK---GEVETLKAKIEGMTQSLRGLELDVVTIRS--- 2392
Query: 148 HEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHE 207
E+E+L +L++ +E+I LE + + LQ+ ++E+ ++K + L L
Sbjct: 2393 -EKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELN 2451
Query: 208 NRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTG 267
R V AL + + + + L +V L+ A+ L+ KN+ +SS + L
Sbjct: 2452 ER---VAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGL-- 2506
Query: 268 VLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVI-QHQ--RQTNKIL 324
+Q++ ED L + IS LK+ + + + + V +HQ ++ N L
Sbjct: 2507 ------IQEV--EDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLEL 2558
Query: 325 GNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSG-QRSRSPLLKFVEQPTENKAD 383
N ELE+K++ L+ SL + + S L + + ++ + FVE+ NK
Sbjct: 2559 RNLTVELEQKIQVLQSKNA-SLQDTLEVLQSSYKNLENELELTKMDKMSFVEK--VNKMT 2615
Query: 384 PKDGEAQKQEEDESCAAAE 402
K+ E Q++ + + AE
Sbjct: 2616 AKETELQREMHEMAQKTAE 2634
Score = 43.9 bits (102), Expect = 4e-04
Identities = 76/362 (20%), Positives = 152/362 (41%), Gaps = 29/362 (8%)
Query: 32 KKEALLILS---KELDTCQQERDQYKLMANQLRERHQSLKKK---YRELIDGDPSLPPEK 85
KKE I+S +E++ QE K + L + +L +K + ID E
Sbjct: 955 KKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISEL 1014
Query: 86 RKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAK-----QRLGDEAI 140
Q +L+ R + G ++L Q+ Q N L + + + +E
Sbjct: 1015 SDQYKQEKLIL--LQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELE 1072
Query: 141 GVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQ-DVKEERSSYQDKVERLNQEL 199
++ A E ++ + +L A+E+ ++L +L+ L+ ++ + +++ + + L QE+
Sbjct: 1073 QLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEI 1132
Query: 200 NHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGK 259
+ +V+ L EN L + +K HE NL I +N+++ R++ + Q
Sbjct: 1133 MTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPI---RNSVKERESERNQCN 1189
Query: 260 SSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQ 319
+V+++ + + L Q + L++ L E+ EK +QH+ Q
Sbjct: 1190 FKPQ------MDLEVKEISLDSYNAQL---VQLEAMLRNKELKLQESEKEKE-CLQHELQ 1239
Query: 320 TNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTE 379
T I G+ + +++ E+SGL + S P S ++ + L+ Q T
Sbjct: 1240 T--IRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTM 1297
Query: 380 NK 381
NK
Sbjct: 1298 NK 1299
Score = 37.4 bits (85), Expect = 0.034
Identities = 93/471 (19%), Positives = 191/471 (40%), Gaps = 75/471 (15%)
Query: 29 LESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQ 88
L+++ + L + ++L+ +E Q A Q + Q + + R ++ E +K+
Sbjct: 435 LQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSME-------EMKKE 487
Query: 89 ANLAQLLRDSQDRNK-HLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAA 147
NL + + + R HL E+K ++Q L + Q + ++ AK + +
Sbjct: 488 NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMK---AKNTSQETMLRDLQEKI 544
Query: 148 HEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHE 207
+++E+ + LE+ K + LE S D L+ + DK+ + +E +LS E
Sbjct: 545 NQQENSLT-LEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALE 603
Query: 208 NRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTG 267
+ ++ ++L EE L ++ + L + ++ K +S + L
Sbjct: 604 LK--------------KKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLET 649
Query: 268 VLSAKQVQDLLSEDHGCSLPATPQSIS-DLKSLATAL------LETIHEKNMVIQ----- 315
L +Q++ + +L +++S ++++L L +ET M +Q
Sbjct: 650 CLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEF 709
Query: 316 ----HQRQTNKI------LGNRVAELEKKLRTLEVSGL----------WSLPGGKDTILF 355
HQ++ + L +V +LE KL+ L + +D +
Sbjct: 710 SDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS 769
Query: 356 SDPTLPSGQRSRSPLLKFVEQPTENKADPK-DGEAQKQEEDESCAAAEALTAPEDAGRPA 414
D +L + + + LL F +QP + + GE + S EA +P+
Sbjct: 770 KDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPK------ 823
Query: 415 VNSPANQSRGNQCKLFHPSLPQLPSEEEVNS-LGREIIKLTKEQAAAELEE 464
NS Q+R + + L S++++NS L ++ +L Q E+EE
Sbjct: 824 -NSAILQNRVDSLEF------SLESQKQMNSDLQKQCEELV--QIKGEIEE 865
Score = 36.6 bits (83), Expect = 0.058
Identities = 46/221 (20%), Positives = 94/221 (42%), Gaps = 30/221 (13%)
Query: 30 ESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQA 89
+ K E+LL KELD+ +L + L K I+ + + K++ +
Sbjct: 1794 DRKVESLLNEMKELDS-------------KLHLQEVQLMTKIEACIELEKIVGELKKENS 1840
Query: 90 NLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAK---QRLGDEAIGVRHFA 146
+L++ L ++ + +EL QR+ +G N L M K + +GD V
Sbjct: 1841 DLSEKL-------EYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSW 1893
Query: 147 AHEREDLVQQLERAKEQIESLEH-------DLQASVDELQDVKEERSSYQDKVERLNQEL 199
D+ +L R + + S+EH DL+ E ++++ + Q + L +EL
Sbjct: 1894 KERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEEL 1953
Query: 200 NHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSN 240
+ + S ++D + + L + +++ E+ L+S+
Sbjct: 1954 SVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESH 1994
Score = 34.7 bits (78), Expect = 0.22
Identities = 73/332 (21%), Positives = 138/332 (41%), Gaps = 49/332 (14%)
Query: 27 RKLESKKEALLILSKELDTCQQERDQYKL--MANQLRER---HQSLKKKYRELID----G 77
+K + + E + + + +L T Q E ++KL ++N++ ++ +Q L +Y L D
Sbjct: 712 QKHQKEIENMCLKTSQL-TGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK 770
Query: 78 DPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGD 137
D SL + Q +L L D Q H I Q G + + R+ A Q +
Sbjct: 771 DASLVTNEDHQRSL--LAFDQQPAMHHSFANIIGEQ---GSMPSERSECRLE-ADQSPKN 824
Query: 138 EAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQ 197
AI ++ V LE + E + + DLQ +EL +K E K E+++Q
Sbjct: 825 SAI---------LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQ 875
Query: 198 -----------ELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKN 246
+L S H+N ++ +EN+ ++ L+ L+++V ++ I + K
Sbjct: 876 SFVAETSQRISKLQEDTSAHQN-VVAETLSALENK--EKELQLLNDKVETEQAEIQELKK 932
Query: 247 ALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLET 306
+ ++S + + S L+ L K++ ++S + I +L L E
Sbjct: 933 SNHLLEDSLKELQLLSETLS--LEKKEMSSIIS--------LNKREIEELTQENGTLKEI 982
Query: 307 IHEKNMVIQHQRQTNKILGNRVAELEKKLRTL 338
N + Q ++ N + E EK + L
Sbjct: 983 NASLNQEKMNLIQKSESFANYIDEREKSISEL 1014
Score = 33.9 bits (76), Expect = 0.38
Identities = 53/279 (18%), Positives = 100/279 (35%), Gaps = 77/279 (27%)
Query: 94 LLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDL 153
LL + +N+ L +I EL+ RL QG K ++ + K ++L
Sbjct: 279 LLDQLKAQNQELRNKINELELRL---QGHEKEMKGQVNKF-----------------QEL 318
Query: 154 VQQLERAKEQIESLEHDLQASVDEL--------------------------------QDV 181
QLE+AK ++ E L DEL Q+
Sbjct: 319 QLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNA 378
Query: 182 KEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENR-YLQERLKQLHEEVNLLKSN 240
+ R S + K++ +E LS + +D C++ + L + L+Q N+L++
Sbjct: 379 ESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAE 438
Query: 241 IAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLA 300
+ K + ++ +N+ + K A Q+++ L
Sbjct: 439 LDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKE--------------------NELR 478
Query: 301 TALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLE 339
++ E E N++ H Q V LE +L+ ++
Sbjct: 479 RSMEEMKKENNLLKSHSEQK----AREVCHLEAELKNIK 513
Score = 32.7 bits (73), Expect = 0.84
Identities = 37/129 (28%), Positives = 60/129 (46%), Gaps = 19/129 (14%)
Query: 84 EKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVR 143
E+ K+ + L+ Q+ L + KE QQR + Q D+ + KQ++ +E
Sbjct: 6 EEWKEGLPTRALQKIQELEGQLDKLKKEKQQR--QFQLDSLEAALQKQKQKVENEKT--- 60
Query: 144 HFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQD--------KVERL 195
E +L ++ +R E ESLE Q ELQ VKE + ++Q+ ++E+L
Sbjct: 61 -----EGTNLKRENQRLMEICESLEKTKQKISHELQ-VKESQVNFQEGQLNSGKKQIEKL 114
Query: 196 NQELNHILS 204
QEL S
Sbjct: 115 EQELKRCKS 123
Score = 30.4 bits (67), Expect = 4.2
Identities = 57/334 (17%), Positives = 120/334 (35%), Gaps = 61/334 (18%)
Query: 39 LSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDS 98
L +LD ++E+ Q + + L Q K+K +L E ++ + + L +
Sbjct: 23 LEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKT 82
Query: 99 QDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLE 158
+ + H ++KE Q E Q + K+++ E L Q+L+
Sbjct: 83 KQKISH-ELQVKESQVNFQEGQ-------LNSGKKQI---------------EKLEQELK 119
Query: 159 RAKEQIESLEHDLQASVDELQDVKEER---------------SSYQDKVERLNQELNHIL 203
R K ++E + Q++ L + S Y+D E+ N+E+
Sbjct: 120 RCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEV---- 175
Query: 204 SGHENRIIDVDALCMENRYLQERLKQL---HEEV--------------NLLKSNIAKYKN 246
E + ++ + ++ + + L Q H ++ S+++
Sbjct: 176 --EERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQ 233
Query: 247 ALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLET 306
R++ S +T S Q+ + ++P + LK+ L
Sbjct: 234 RTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNK 293
Query: 307 IHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEV 340
I+E + +Q + K N+ EL+ +L +V
Sbjct: 294 INELELRLQGHEKEMKGQVNKFQELQLQLEKAKV 327
>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
isoform 1 [Homo sapiens]
Length = 693
Score = 57.4 bits (137), Expect = 3e-08
Identities = 104/509 (20%), Positives = 201/509 (39%), Gaps = 68/509 (13%)
Query: 20 SEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDP 79
S+Y LES + L++ +++ +Q++ Q + + ++ + + K E ++
Sbjct: 69 SQYQELAVALESSSVTINQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMEQLETIN 128
Query: 80 SLPPEKRKQANLAQLLRDSQDRNKHLGEEIKE----LQQRLGEVQGDNKLLRMTIAKQRL 135
L EK A+L L ++ +H EE K+ LQ L +Q + L +Q+
Sbjct: 129 ILTLEK---ADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQRIQELERALSAVSTQQQE 185
Query: 136 GDEAIGVRHFAAHER-EDLVQQ---LERAKEQIESLEHDLQASVDE-LQDVKEERSSYQD 190
D + R R + +++ L Q+ +Q DE + +K ER+ +Q+
Sbjct: 186 EDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQE 245
Query: 191 KVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNAL-E 249
++ +++ E + E + D+ + R L E Q+ E +L + L +
Sbjct: 246 RMWKMSVEARTL---KEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQD 302
Query: 250 RRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHE 309
K+ + + + L + Q LLS++ L + + + ++ E + E
Sbjct: 303 EAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCE 362
Query: 310 KNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSP 369
+N ++ Q++T + G R+ + E++LR E + +R +
Sbjct: 363 QNERLREQQKTLQEQGERLRKQEQRLRKQE-----------------ERLRKEEERLQKQ 405
Query: 370 LLKFVEQPTENKADPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKL 429
+ +Q E + K+ QKQEE + + L Q QC
Sbjct: 406 EKRLWDQ--EERLWKKEERLQKQEERLALSQNHKLD--------------KQLAEPQC-- 447
Query: 430 FHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIE-----GQRSETGPAPPG 484
S E++N+ + ++L EQ EL+E E +E Q+ ET +
Sbjct: 448 ---------SFEDLNNEKKSALQL--EQQVKELQEKLDEEHLEAASQRNQQLETQLSLVA 496
Query: 485 LAIQGELPKSHLDSFEASRPAAKASTPED 513
L +G+ HLDS E P + PED
Sbjct: 497 LPGEGD-GGQHLDSEEEEAPRPTPNIPED 524
Score = 51.6 bits (122), Expect = 2e-06
Identities = 82/409 (20%), Positives = 160/409 (39%), Gaps = 54/409 (13%)
Query: 12 ESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKY 71
E + + L ++++ + AL +S T QQE D+ + +R K
Sbjct: 152 EEESKDLAGRLQYSLQRIQELERALSAVS----TQQQEEDRSSSCREAVLQRRLQQTIKE 207
Query: 72 RELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLR---- 127
R L++ + E KQ QL RD + KH+ E Q+R+ ++ + + L+
Sbjct: 208 RALLNAHVTQVTESLKQV---QLERD--EYAKHIKGERARWQERMWKMSVEARTLKEEKK 262
Query: 128 ------------MTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASV 175
++ K ++ + E L + + ++++E LE LQ+ V
Sbjct: 263 RDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQV 322
Query: 176 DELQDV----KEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLH 231
+ Q + KE++ Q++ E L ++ R+ + + LC +N L+E+ K L
Sbjct: 323 ENNQALSLLSKEQKQRLQEQEEMLREQ-------EAQRVREQERLCEQNERLREQQKTLQ 375
Query: 232 EEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSA--KQVQDLLSEDHGCSLPAT 289
E+ L+ + + ER + + + + L K+ + L ++ +L
Sbjct: 376 EQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQN 435
Query: 290 PQSISDLKSLATALLETIHEKNMVIQHQRQT----NKILGNRVAELEKKLRTLEVS-GLW 344
+ L + + +EK +Q ++Q K+ + ++ + LE L
Sbjct: 436 HKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEHLEAASQRNQQLETQLSLV 495
Query: 345 SLPGGKDTILFSD----------PTLPSGQRSRSPLLKFVEQPTENKAD 383
+LPG D D P +P SR F++ P E KAD
Sbjct: 496 ALPGEGDGGQHLDSEEEEAPRPTPNIPEDLESREATSSFMDLPKE-KAD 543
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 57.4 bits (137), Expect = 3e-08
Identities = 118/556 (21%), Positives = 213/556 (38%), Gaps = 76/556 (13%)
Query: 9 DRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQE--------------RDQYK 54
+R+ + L + V ++L +EAL + + D Q E R + +
Sbjct: 662 ERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELE 721
Query: 55 LMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDS----QDRNKHLGEEI- 109
L +LR SL+ +L + SL +K L L + Q R + +E
Sbjct: 722 LSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT 781
Query: 110 --KELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQL-------ERA 160
+E Q+RL E++ L +A+Q L G A +E L QQL +
Sbjct: 782 VAREEQERLEELR-----LEQEVARQGLE----GSLRVAEQAQEALEQQLPTLRHERSQL 832
Query: 161 KEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMEN 220
+EQ+ L L EL+ + E + +ER +E + H + + A E
Sbjct: 833 QEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREG 892
Query: 221 RYLQERLKQLHEEVNLLKSNIAKYKNAL----ERRKNSKGQGKS---SSSALTGVLSAKQ 273
R L E +L E L+ ++ + + L RR+ + +G++ + LTG L+ +
Sbjct: 893 RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLR 952
Query: 274 VQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTN-KILGNRVAELE 332
Q + +++ ++ D + +A L++ E ++ QR + + L E E
Sbjct: 953 QQIIATQE---------KASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKE 1003
Query: 333 KKLRTLEVSGLW---SLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTEN---KADPKD 386
R LE L ++ +L L + + S + ++Q + A+ +
Sbjct: 1004 AAWRELEAERAQLQSQLQREQEELL---ARLEAEKEELSEEIAALQQERDEGLLLAESEK 1060
Query: 387 GEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSL 446
+A +E E A +E L + Q R Q + Q VN+L
Sbjct: 1061 QQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSR-------QEQDRSTVNAL 1113
Query: 447 GREIIKL---TKEQAAAELEEVRRESPIEGQRSETGPAPPGLAIQGELPKSHLDSFEASR 503
E+ L +E AAA +EVRR ++ Q + G + E ++ L E +R
Sbjct: 1114 TSELRDLRAQREEAAAAHAQEVRR---LQEQARDLGKQRDSCLREAEELRTQLRLLEDAR 1170
Query: 504 PAAKASTPEDGKGIPE 519
+ E + + E
Sbjct: 1171 DGLRRELLEAQRKLRE 1186
Score = 54.7 bits (130), Expect = 2e-07
Identities = 85/416 (20%), Positives = 174/416 (41%), Gaps = 54/416 (12%)
Query: 95 LRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHE-REDL 153
++D + R + + + L+++L + + + + L + QRL D+ G AHE +
Sbjct: 535 VQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQL--QRLRDKTDGAMQ--AHEDAQRE 590
Query: 154 VQQLERAKEQIE----SLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENR 209
VQ+L A E + +L H LQ + + +++++ER Q E L ++ + + E+
Sbjct: 591 VQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDA 650
Query: 210 IIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVL 269
+ D + E +L+QL + ++L + + + AL R + ++ + + L
Sbjct: 651 VQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEAL 710
Query: 270 SAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHE-----KNMVIQHQRQTNKIL 324
+ + + E L A S+ D S +AL E++ + +V Q + + + +
Sbjct: 711 TKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQ 770
Query: 325 GNR---------VAELEKKLRTLEVSGLWSLPGGKDTILFSDPT-------LPSGQRSRS 368
G + E +++L L + + G + ++ ++ LP+ + RS
Sbjct: 771 GRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERS 830
Query: 369 PLLKFVEQPT------ENKADPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQS 422
L + + Q + E + + EAQ+Q E AA E ++ AV A +
Sbjct: 831 QLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAER 890
Query: 423 RGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRE-SPIEGQRSE 477
G SEE ++L KE L EV+R+ + +E +R +
Sbjct: 891 EGRTL-----------SEEATR------LRLEKEALEGSLFEVQRQLAQLEARREQ 929
Score = 50.1 bits (118), Expect = 5e-06
Identities = 109/518 (21%), Positives = 210/518 (40%), Gaps = 66/518 (12%)
Query: 2 EEEAMNGDRTESDW--QGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQ 59
E+E + R E + QGL V ++ E+ ++ L L E Q++ Q ++ Q
Sbjct: 786 EQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ---LSRQ 842
Query: 60 LRERHQSLKKKYREL---IDGDPSLPPEK----RKQANLAQLLRDSQDRNKHLGEE---- 108
L R Q L++ RE ++ EK ++ A LA L ++ + L EE
Sbjct: 843 LSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRL 902
Query: 109 ----------IKELQQRLGEVQGDNKLLR-----MTIAKQRLGDEAIGVRHF-------A 146
+ E+Q++L +++ + L + +AK+ L E G+R A
Sbjct: 903 RLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKA 962
Query: 147 AHEREDLVQQLERAKEQIE-SLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSG 205
+ ++E + Q+L +A+ + + SL A ++LQ ++ E+ + ++E +L L
Sbjct: 963 SLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQR 1022
Query: 206 HENRIIDVDALCMENRYLQERLKQLHEEVN---LL----KSNIAKYKNALERRKNSKGQG 258
+ ++ L E L E + L +E + LL K K + + + K G
Sbjct: 1023 EQEELLA--RLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMG 1080
Query: 259 KSSSSALTGVLSAKQVQDLLS--EDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQH 316
S A + +Q +D S E ++ A + DL++ ++ +Q
Sbjct: 1081 TRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQE 1140
Query: 317 Q-----RQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLL 371
Q +Q + L EL +LR LE + G + +L + L Q R
Sbjct: 1141 QARDLGKQRDSCL-REAEELRTQLRLLEDAR----DGLRRELLEAQRKLRESQEGRE--- 1192
Query: 372 KFVEQPTENKADPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSP-ANQSRGNQCKLF 430
V++ + GE K+ E + E +A + A ++ AN+ + + L
Sbjct: 1193 --VQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALL 1250
Query: 431 HPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRE 468
+ + E G + ++ ++ +A EL+E+RR+
Sbjct: 1251 EEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQ 1288
Score = 43.1 bits (100), Expect = 6e-04
Identities = 71/342 (20%), Positives = 143/342 (41%), Gaps = 41/342 (11%)
Query: 3 EEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRE 62
EE + R ++D G + + +R+++ + A +LS+E + A +LR+
Sbjct: 567 EEQLQRLRDKTD--GAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQ 624
Query: 63 RHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGD 122
+ L+ EL +R++ L + D+ + E++ ++L +++G
Sbjct: 625 EREKLQAAQEEL----------RRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGK 674
Query: 123 NKLLRMTIAKQRLG-DEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDV 181
+L + + R A R E+ ++ + L +A E+ +L+ S+ +L
Sbjct: 675 RSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKA----EAGRVELELSMTKL--- 727
Query: 182 KEERSSYQDKVERLNQELNHILSGHE---NRIIDVDALCMENRYLQERLKQLHEEVNLLK 238
+ E +S QD + +L+ LN L+ + NR+ V L E LQ R +Q +E + +
Sbjct: 728 RAEEASLQDSLSKLS-ALNESLAQDKLDLNRL--VAQLEEEKSALQGRQRQAEQEATVAR 784
Query: 239 SNIAKYKNALERRKNSKGQGKSSSSALTGVLS-AKQVQDLLSEDHGCSLPATPQSISDLK 297
ER + + + + + L G L A+Q Q+ L + LP S L+
Sbjct: 785 EE-------QERLEELRLEQEVARQGLEGSLRVAEQAQEALEQ----QLPTLRHERSQLQ 833
Query: 298 SLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLE 339
L + + ++ R+ + +V LE+ R E
Sbjct: 834 EQLAQLSRQLSGREQELEQARREAQ---RQVEALERAAREKE 872
Score = 42.4 bits (98), Expect = 0.001
Identities = 93/474 (19%), Positives = 205/474 (43%), Gaps = 39/474 (8%)
Query: 16 QGLVSEYLVCKRKLESKKEALLI----LSKELDTCQQERDQYKLMANQLRERHQSLKKKY 71
+G + E+L R + +++ L L+++L + ERD A QL ++ + ++
Sbjct: 1508 RGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQL-QKAVAESEEA 1566
Query: 72 RELIDGDPSLPPEKRKQANLA---QLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRM 128
R +DG S QA LA + +R S+ + +++ L++ L + + + +
Sbjct: 1567 RRSVDGRLS-----GVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQE 1621
Query: 129 TIAKQRLGDEAI-GVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSS 187
I+K + + + G + + + + + Q SLE +LQ S L D + + +
Sbjct: 1622 KISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQA 1681
Query: 188 YQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNA 247
QD+V+ L +++ + + L + L L ++ E L+ + A
Sbjct: 1682 LQDRVDSLQRQV-------ADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEA 1734
Query: 248 LERRKNSKGQGKSSSSALTGVLSA-KQVQDLLSEDHGCSLPATPQSISDLKSLATAL--- 303
L + S + + L L+A + + +L E L A Q++S+ + +++L
Sbjct: 1735 LAQSSASLNSTRDKNLHLQKALTACEHDRQVLQE----RLDAARQALSEARKQSSSLGEQ 1790
Query: 304 LETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSG 363
++T+ + ++ QR + ++ E+ ++ + E + L ++ +D L S
Sbjct: 1791 VQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSL 1850
Query: 364 QRSRSPLLKFVEQPTENKA--DPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQ 421
QR+ + L+ ++ E A KD A ++ D+ E L + ED V A +
Sbjct: 1851 QRALAQ-LEAEKREVERSALRLEKDRVALRRTLDK--VEREKLRSHED----TVRLSAEK 1903
Query: 422 SRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIEGQR 475
R ++ L L ++ ++ L +++ L + + A+LE ++ +E Q+
Sbjct: 1904 GRLDR-TLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQ 1956
Score = 40.8 bits (94), Expect = 0.003
Identities = 70/358 (19%), Positives = 144/358 (40%), Gaps = 46/358 (12%)
Query: 16 QGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELI 75
Q L S + R+ + +L + ++ + +QER++ + +LR + L+++ + +
Sbjct: 592 QRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAV 651
Query: 76 -DGDPSLPPEKRKQANLAQL-------------LRDSQDR----NKHLGEEIKELQQRLG 117
DG +R L QL +R++ R L E E+ + L
Sbjct: 652 QDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALT 711
Query: 118 EVQGDNKLLRMTIAKQRLGDEAI--------GVRHFAAHEREDLVQQLERAKEQIESLEH 169
+ + L +++ K R + ++ + A ++ DL + + + +E+ +L+
Sbjct: 712 KAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQG 771
Query: 170 DLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQ 229
+ + E +EE Q+++E L E G E + + L+++L
Sbjct: 772 RQRQAEQEATVAREE----QERLEELRLEQEVARQGLEGSLRVAE---QAQEALEQQLPT 824
Query: 230 LHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLS-AKQVQDLLSEDH---GCS 285
L E + L+ +A+ L R+ Q + + L A + ++ L+++H
Sbjct: 825 LRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQ 884
Query: 286 LPATPQSISDLKSLATAL-LETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSG 342
L A + L AT L LE + + + QRQ +A+LE + LE G
Sbjct: 885 LVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQ--------LAQLEARREQLEAEG 934
Score = 40.4 bits (93), Expect = 0.004
Identities = 58/266 (21%), Positives = 116/266 (43%), Gaps = 41/266 (15%)
Query: 39 LSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDS 98
L K+ D+C +E ++ + L + L+ REL++ +RK LR+S
Sbjct: 1145 LGKQRDSCLREAEELRTQLRLLEDARDGLR---RELLEA-------QRK-------LRES 1187
Query: 99 QDRNKHLGEEIKELQQRLGEVQGDNKLLR-----MTIAKQRLGDEAIGVRHFAAHEREDL 153
Q+ + +E EL++ LGE + + LR + A ++ E I ++ A ++E
Sbjct: 1188 QEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLK-LANEDKEQK 1246
Query: 154 VQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDV 213
+ LE A+ + +L+ LQ+V+ R + +++ L +++ + S EN +
Sbjct: 1247 LALLEEARTAVGKEAGELRTG---LQEVERSRLEARRELQELRRQMKMLDS--ENTRLGR 1301
Query: 214 DALCMENRY-LQERL-KQLHEEVNLLKSNIAKYKNALE-----------RRKNSKGQGKS 260
+ ++ R L ER K+ E L+ + K + +LE + + +G+ ++
Sbjct: 1302 ELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRT 1361
Query: 261 SSSALTGVLSAKQVQDLLSEDHGCSL 286
L G L + + DH L
Sbjct: 1362 RERRLLGSLEEARGTEKQQLDHARGL 1387
Score = 39.7 bits (91), Expect = 0.007
Identities = 65/337 (19%), Positives = 135/337 (40%), Gaps = 64/337 (18%)
Query: 30 ESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQA 89
E+ + AL +EL + Q+ERD +LR + +L ++ E+
Sbjct: 1505 EAVRGALREFLQELRSAQRERD-------ELRTQTSALNRQLAEM--------------- 1542
Query: 90 NLAQLLRDS-QDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAH 148
+ RDS R + L + + E ++ V G R++ + L + VR +
Sbjct: 1543 ---EAERDSATSRARQLQKAVAESEEARRSVDG-----RLSGVQAELALQEESVRR-SER 1593
Query: 149 EREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHEN 208
ER + Q+ + +++ E +L+AS +++ +K + + K+E + L +L E+
Sbjct: 1594 ERRATLDQVATLERSLQATESELRASQEKISKMK----ANETKLEGDKRRLKEVLDASES 1649
Query: 209 RIIDVD-------------ALCMENR-----YLQERLKQLHEEV-------NLLKSNIAK 243
R + ++ L + +R LQ+R+ L +V L+ + +
Sbjct: 1650 RTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVER 1709
Query: 244 YKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATAL 303
AL + + S+G + LT L+ + D L ++++ + L
Sbjct: 1710 LNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHL---QKALTACEHDRQVL 1766
Query: 304 LETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEV 340
E + + R+ + LG +V L ++ LE+
Sbjct: 1767 QERLDAARQALSEARKQSSSLGEQVQTLRGEVADLEL 1803
Score = 38.9 bits (89), Expect = 0.012
Identities = 70/331 (21%), Positives = 128/331 (38%), Gaps = 45/331 (13%)
Query: 144 HFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHIL 203
H A H+R+ VQ + E + L L+ +L D + ER + +++++RL + + +
Sbjct: 525 HSALHKRQLQVQDMRGRYEASQDLLGTLRK---QLSDSESERRALEEQLQRLRDKTDGAM 581
Query: 204 SGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSS 263
HE+ +V +RL+ +E ++ KSN+A +++ Q +
Sbjct: 582 QAHEDAQREV-----------QRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQ 630
Query: 264 ALTGVLSAKQVQDLLSEDHGCS----------LPATPQSISDLKSLATALLETIHEKNMV 313
A L ++ +D L E+ + L + + + L+ + L + + E
Sbjct: 631 AAQEEL--RRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREA 688
Query: 314 IQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKF 373
+ +L AE+ + L E +G L + + +L Q S S L
Sbjct: 689 LSRATLQRDMLQAEKAEVAEALTKAE-AGRVELELSMTKLRAEEASL---QDSLSKLSAL 744
Query: 374 VEQPTENKADPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKLFHPS 433
E ++K D AQ +EE + + A + A + Q R
Sbjct: 745 NESLAQDKLDLNRLVAQLEEEKSALQGRQ-----RQAEQEATVAREEQER---------- 789
Query: 434 LPQLPSEEEVNSLGREIIKLTKEQAAAELEE 464
L +L E+EV G E EQA LE+
Sbjct: 790 LEELRLEQEVARQGLEGSLRVAEQAQEALEQ 820
Score = 37.0 bits (84), Expect = 0.045
Identities = 50/226 (22%), Positives = 98/226 (43%), Gaps = 23/226 (10%)
Query: 66 SLKKKYRELIDGDPSLP--PEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDN 123
SL RE++ + S P P +A LL L EE + LQQ L V+
Sbjct: 46 SLPALIREIVTRNLSQPESPVLLPATEMASLLS--------LQEENQLLQQELSRVED-- 95
Query: 124 KLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKE 183
+A+ R + + +++ A ER + +LE + + + ++ SV+ + ++E
Sbjct: 96 -----LLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQE 150
Query: 184 ERSSYQDKVERL---NQELNHILSGHENRIIDVDALCME-NRYLQERLKQLHEEVNLLKS 239
E++SY+ K++ Q ++ + +I+ C E + L ER +L ++
Sbjct: 151 EQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTE 210
Query: 240 NIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCS 285
+ ++AL R + Q +S+S A + +Q+ S + S
Sbjct: 211 HSQDLESALIRLEEE--QQRSASLAQVNAMLREQLDQAGSANQALS 254
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 57.4 bits (137), Expect = 3e-08
Identities = 108/490 (22%), Positives = 206/490 (42%), Gaps = 76/490 (15%)
Query: 2 EEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALL-----------ILSKELDTCQQER 50
+++ ++ E + + ++ + + +++ K E L IL E+ T +E
Sbjct: 1484 QKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEED 1543
Query: 51 DQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIK 110
L L + + +K + + ++ ++ NL + + + + +N+ L E
Sbjct: 1544 SISNLKLGTLNGSQEEMWQKTETVKQENAAV---QKMVENLKKQISELKIKNQQLDLENT 1600
Query: 111 ELQQRLGEVQG-----DNKLLRMTIAKQRL-GDEAIGVRHFAAHEREDLVQQLERAKEQI 164
EL Q+ + Q + +L M K++ G+ A+ R E+ +L ++LER K Q
Sbjct: 1601 ELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEERE---QEKFNLKEELERCKVQS 1657
Query: 165 ESLEHDLQASVDELQD----VKEERSSYQDKVERLNQELNHI--LSGHENRIIDVDALCM 218
+L L+A + E++ V++E +D++E++ Q L+ LS + +I V L
Sbjct: 1658 STLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ-LHRCPDLSDFQQKISSV--LSY 1714
Query: 219 ENRYLQERLKQLHEEVN-----LLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQ 273
+ L+E+ + L EE+N L KS++ +++ A +++ + +S+S V S ++
Sbjct: 1715 NEKLLKEK-EALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEK 1773
Query: 274 VQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEK 333
VQ+L +L + SDL+ V Q +++ K V L K
Sbjct: 1774 VQNLEDTVQNVNLQMSRMK-SDLR---------------VTQQEKEALK---QEVMSLHK 1814
Query: 334 KLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQK-- 391
+L+ GGK T PSG ++ L + +K D E Q+
Sbjct: 1815 QLQNA---------GGKSWAP-EIATHPSGLHNQQKRLSW------DKLDHLMNEEQQLL 1858
Query: 392 -QEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREI 450
QE + + A R V + K +PS P+E+E SL RE
Sbjct: 1859 WQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC 1918
Query: 451 IKLTKEQAAA 460
+ KEQ+ A
Sbjct: 1919 DQFQKEQSPA 1928
Score = 44.7 bits (104), Expect = 2e-04
Identities = 85/420 (20%), Positives = 157/420 (37%), Gaps = 81/420 (19%)
Query: 39 LSKELDTCQQERDQYKLMANQLRERHQS-LKKKYRELIDGDPSLPPEKRKQANLAQLLRD 97
L EL ++ +Y+ + N+L+ ++ L +K+ +L DPS ++ L Q+ +
Sbjct: 489 LENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDL---DPSSAEFFLQEERLTQMRNE 545
Query: 98 SQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTI----------------AKQRLGDEAIG 141
+ + + L +++ ELQ L E + ++LR+ + + LG E
Sbjct: 546 YERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECN 605
Query: 142 ---------------------------------VRHFAAHEREDLV---QQLERAKEQIE 165
VRH+ E +V + E K++ E
Sbjct: 606 PLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE 665
Query: 166 SLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDA-LCMENRYLQ 224
+ H L+ ++ D+K E + Q + L + + HE + L E +LQ
Sbjct: 666 NETHTLE---KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
Query: 225 ERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGC 284
E+L+ HE LK+ + + + + ER + + + G+ L + H
Sbjct: 723 EKLRLQHEME--LKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE------LEQFH-- 772
Query: 285 SLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLW 344
+ ++ L T E + K ++ +HQR+ + G E E RT ++ +
Sbjct: 773 -----QEQLTSLVEKHTLEKEEL-RKELLEKHQRELQE--GREKMETECNRRTSQIEAQF 824
Query: 345 SLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAEAL 404
K T R R L EQ E K+ E +K E + CA A+ L
Sbjct: 825 QSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKS---QWEFEKDELTQECAEAQEL 881
Score = 37.0 bits (84), Expect = 0.045
Identities = 53/239 (22%), Positives = 98/239 (41%), Gaps = 55/239 (23%)
Query: 38 ILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRD 97
++++E QE ++ + M + ++K R+L + +L P+ +K N + +
Sbjct: 1850 LMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQL---ESNLLPKHQKHLNPSGTMNP 1906
Query: 98 SQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQL 157
++ L E + Q+ + + K+ +M +Q L E I + E E L ++
Sbjct: 1907 TEQEKLSLKRECDQFQKE--QSPANRKVSQMNSLEQEL--ETIHL------ENEGLKKKQ 1956
Query: 158 ERAKEQIESLEH--------------DLQA-------SVDELQDVKEERSSYQDKVERLN 196
+ EQ+ ++H DLQ V Q ++ +R Q ER+N
Sbjct: 1957 VKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQ--AERIN 2014
Query: 197 QELNHILSGH------------------ENRIIDVDA-LCMENRYLQERLKQLHEEVNL 236
Q L L E R+I+V+ L + R LQE++ QL E+V+L
Sbjct: 2015 QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
>gi|33946321 ninein isoform 5 [Homo sapiens]
Length = 2090
Score = 57.4 bits (137), Expect = 3e-08
Identities = 108/490 (22%), Positives = 206/490 (42%), Gaps = 76/490 (15%)
Query: 2 EEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALL-----------ILSKELDTCQQER 50
+++ ++ E + + ++ + + +++ K E L IL E+ T +E
Sbjct: 1478 QKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEED 1537
Query: 51 DQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIK 110
L L + + +K + + ++ ++ NL + + + + +N+ L E
Sbjct: 1538 SISNLKLGTLNGSQEEMWQKTETVKQENAAV---QKMVENLKKQISELKIKNQQLDLENT 1594
Query: 111 ELQQRLGEVQG-----DNKLLRMTIAKQRL-GDEAIGVRHFAAHEREDLVQQLERAKEQI 164
EL Q+ + Q + +L M K++ G+ A+ R E+ +L ++LER K Q
Sbjct: 1595 ELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEERE---QEKFNLKEELERCKVQS 1651
Query: 165 ESLEHDLQASVDELQD----VKEERSSYQDKVERLNQELNHI--LSGHENRIIDVDALCM 218
+L L+A + E++ V++E +D++E++ Q L+ LS + +I V L
Sbjct: 1652 STLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ-LHRCPDLSDFQQKISSV--LSY 1708
Query: 219 ENRYLQERLKQLHEEVN-----LLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQ 273
+ L+E+ + L EE+N L KS++ +++ A +++ + +S+S V S ++
Sbjct: 1709 NEKLLKEK-EALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEK 1767
Query: 274 VQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEK 333
VQ+L +L + SDL+ V Q +++ K V L K
Sbjct: 1768 VQNLEDTVQNVNLQMSRMK-SDLR---------------VTQQEKEALK---QEVMSLHK 1808
Query: 334 KLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQK-- 391
+L+ GGK T PSG ++ L + +K D E Q+
Sbjct: 1809 QLQNA---------GGKSWAP-EIATHPSGLHNQQKRLSW------DKLDHLMNEEQQLL 1852
Query: 392 -QEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREI 450
QE + + A R V + K +PS P+E+E SL RE
Sbjct: 1853 WQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC 1912
Query: 451 IKLTKEQAAA 460
+ KEQ+ A
Sbjct: 1913 DQFQKEQSPA 1922
Score = 44.7 bits (104), Expect = 2e-04
Identities = 85/420 (20%), Positives = 157/420 (37%), Gaps = 81/420 (19%)
Query: 39 LSKELDTCQQERDQYKLMANQLRERHQS-LKKKYRELIDGDPSLPPEKRKQANLAQLLRD 97
L EL ++ +Y+ + N+L+ ++ L +K+ +L DPS ++ L Q+ +
Sbjct: 483 LENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDL---DPSSAEFFLQEERLTQMRNE 539
Query: 98 SQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTI----------------AKQRLGDEAIG 141
+ + + L +++ ELQ L E + ++LR+ + + LG E
Sbjct: 540 YERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECN 599
Query: 142 ---------------------------------VRHFAAHEREDLV---QQLERAKEQIE 165
VRH+ E +V + E K++ E
Sbjct: 600 PLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE 659
Query: 166 SLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDA-LCMENRYLQ 224
+ H L+ ++ D+K E + Q + L + + HE + L E +LQ
Sbjct: 660 NETHTLE---KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
Query: 225 ERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGC 284
E+L+ HE LK+ + + + + ER + + + G+ L + H
Sbjct: 717 EKLRLQHEME--LKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE------LEQFH-- 766
Query: 285 SLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLW 344
+ ++ L T E + K ++ +HQR+ + G E E RT ++ +
Sbjct: 767 -----QEQLTSLVEKHTLEKEEL-RKELLEKHQRELQE--GREKMETECNRRTSQIEAQF 818
Query: 345 SLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAEAL 404
K T R R L EQ E K+ E +K E + CA A+ L
Sbjct: 819 QSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKS---QWEFEKDELTQECAEAQEL 875
Score = 37.0 bits (84), Expect = 0.045
Identities = 53/239 (22%), Positives = 98/239 (41%), Gaps = 55/239 (23%)
Query: 38 ILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRD 97
++++E QE ++ + M + ++K R+L + +L P+ +K N + +
Sbjct: 1844 LMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQL---ESNLLPKHQKHLNPSGTMNP 1900
Query: 98 SQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQL 157
++ L E + Q+ + + K+ +M +Q L E I + E E L ++
Sbjct: 1901 TEQEKLSLKRECDQFQKE--QSPANRKVSQMNSLEQEL--ETIHL------ENEGLKKKQ 1950
Query: 158 ERAKEQIESLEH--------------DLQA-------SVDELQDVKEERSSYQDKVERLN 196
+ EQ+ ++H DLQ V Q ++ +R Q ER+N
Sbjct: 1951 VKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQ--AERIN 2008
Query: 197 QELNHILSGH------------------ENRIIDVDA-LCMENRYLQERLKQLHEEVNL 236
Q L L E R+I+V+ L + R LQE++ QL E+V+L
Sbjct: 2009 QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2067
>gi|148536871 ninein isoform 1 [Homo sapiens]
Length = 2046
Score = 57.4 bits (137), Expect = 3e-08
Identities = 108/490 (22%), Positives = 206/490 (42%), Gaps = 76/490 (15%)
Query: 2 EEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALL-----------ILSKELDTCQQER 50
+++ ++ E + + ++ + + +++ K E L IL E+ T +E
Sbjct: 1478 QKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEED 1537
Query: 51 DQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIK 110
L L + + +K + + ++ ++ NL + + + + +N+ L E
Sbjct: 1538 SISNLKLGTLNGSQEEMWQKTETVKQENAAV---QKMVENLKKQISELKIKNQQLDLENT 1594
Query: 111 ELQQRLGEVQG-----DNKLLRMTIAKQRL-GDEAIGVRHFAAHEREDLVQQLERAKEQI 164
EL Q+ + Q + +L M K++ G+ A+ R E+ +L ++LER K Q
Sbjct: 1595 ELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEERE---QEKFNLKEELERCKVQS 1651
Query: 165 ESLEHDLQASVDELQD----VKEERSSYQDKVERLNQELNHI--LSGHENRIIDVDALCM 218
+L L+A + E++ V++E +D++E++ Q L+ LS + +I V L
Sbjct: 1652 STLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ-LHRCPDLSDFQQKISSV--LSY 1708
Query: 219 ENRYLQERLKQLHEEVN-----LLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQ 273
+ L+E+ + L EE+N L KS++ +++ A +++ + +S+S V S ++
Sbjct: 1709 NEKLLKEK-EALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEK 1767
Query: 274 VQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEK 333
VQ+L +L + SDL+ V Q +++ K V L K
Sbjct: 1768 VQNLEDTVQNVNLQMSRMK-SDLR---------------VTQQEKEALK---QEVMSLHK 1808
Query: 334 KLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQK-- 391
+L+ GGK T PSG ++ L + +K D E Q+
Sbjct: 1809 QLQNA---------GGKSWAP-EIATHPSGLHNQQKRLSW------DKLDHLMNEEQQLL 1852
Query: 392 -QEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREI 450
QE + + A R V + K +PS P+E+E SL RE
Sbjct: 1853 WQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC 1912
Query: 451 IKLTKEQAAA 460
+ KEQ+ A
Sbjct: 1913 DQFQKEQSPA 1922
Score = 44.7 bits (104), Expect = 2e-04
Identities = 85/420 (20%), Positives = 157/420 (37%), Gaps = 81/420 (19%)
Query: 39 LSKELDTCQQERDQYKLMANQLRERHQS-LKKKYRELIDGDPSLPPEKRKQANLAQLLRD 97
L EL ++ +Y+ + N+L+ ++ L +K+ +L DPS ++ L Q+ +
Sbjct: 483 LENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDL---DPSSAEFFLQEERLTQMRNE 539
Query: 98 SQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTI----------------AKQRLGDEAIG 141
+ + + L +++ ELQ L E + ++LR+ + + LG E
Sbjct: 540 YERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECN 599
Query: 142 ---------------------------------VRHFAAHEREDLV---QQLERAKEQIE 165
VRH+ E +V + E K++ E
Sbjct: 600 PLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE 659
Query: 166 SLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDA-LCMENRYLQ 224
+ H L+ ++ D+K E + Q + L + + HE + L E +LQ
Sbjct: 660 NETHTLE---KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
Query: 225 ERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGC 284
E+L+ HE LK+ + + + + ER + + + G+ L + H
Sbjct: 717 EKLRLQHEME--LKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE------LEQFH-- 766
Query: 285 SLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLW 344
+ ++ L T E + K ++ +HQR+ + G E E RT ++ +
Sbjct: 767 -----QEQLTSLVEKHTLEKEEL-RKELLEKHQRELQE--GREKMETECNRRTSQIEAQF 818
Query: 345 SLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAEAL 404
K T R R L EQ E K+ E +K E + CA A+ L
Sbjct: 819 QSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKS---QWEFEKDELTQECAEAQEL 875
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 57.4 bits (137), Expect = 3e-08
Identities = 108/490 (22%), Positives = 206/490 (42%), Gaps = 76/490 (15%)
Query: 2 EEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALL-----------ILSKELDTCQQER 50
+++ ++ E + + ++ + + +++ K E L IL E+ T +E
Sbjct: 1478 QKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEED 1537
Query: 51 DQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIK 110
L L + + +K + + ++ ++ NL + + + + +N+ L E
Sbjct: 1538 SISNLKLGTLNGSQEEMWQKTETVKQENAAV---QKMVENLKKQISELKIKNQQLDLENT 1594
Query: 111 ELQQRLGEVQG-----DNKLLRMTIAKQRL-GDEAIGVRHFAAHEREDLVQQLERAKEQI 164
EL Q+ + Q + +L M K++ G+ A+ R E+ +L ++LER K Q
Sbjct: 1595 ELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEERE---QEKFNLKEELERCKVQS 1651
Query: 165 ESLEHDLQASVDELQD----VKEERSSYQDKVERLNQELNHI--LSGHENRIIDVDALCM 218
+L L+A + E++ V++E +D++E++ Q L+ LS + +I V L
Sbjct: 1652 STLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ-LHRCPDLSDFQQKISSV--LSY 1708
Query: 219 ENRYLQERLKQLHEEVN-----LLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQ 273
+ L+E+ + L EE+N L KS++ +++ A +++ + +S+S V S ++
Sbjct: 1709 NEKLLKEK-EALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEK 1767
Query: 274 VQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEK 333
VQ+L +L + SDL+ V Q +++ K V L K
Sbjct: 1768 VQNLEDTVQNVNLQMSRMK-SDLR---------------VTQQEKEALK---QEVMSLHK 1808
Query: 334 KLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQK-- 391
+L+ GGK T PSG ++ L + +K D E Q+
Sbjct: 1809 QLQNA---------GGKSWAP-EIATHPSGLHNQQKRLSW------DKLDHLMNEEQQLL 1852
Query: 392 -QEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREI 450
QE + + A R V + K +PS P+E+E SL RE
Sbjct: 1853 WQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC 1912
Query: 451 IKLTKEQAAA 460
+ KEQ+ A
Sbjct: 1913 DQFQKEQSPA 1922
Score = 44.7 bits (104), Expect = 2e-04
Identities = 85/420 (20%), Positives = 157/420 (37%), Gaps = 81/420 (19%)
Query: 39 LSKELDTCQQERDQYKLMANQLRERHQS-LKKKYRELIDGDPSLPPEKRKQANLAQLLRD 97
L EL ++ +Y+ + N+L+ ++ L +K+ +L DPS ++ L Q+ +
Sbjct: 483 LENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDL---DPSSAEFFLQEERLTQMRNE 539
Query: 98 SQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTI----------------AKQRLGDEAIG 141
+ + + L +++ ELQ L E + ++LR+ + + LG E
Sbjct: 540 YERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECN 599
Query: 142 ---------------------------------VRHFAAHEREDLV---QQLERAKEQIE 165
VRH+ E +V + E K++ E
Sbjct: 600 PLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE 659
Query: 166 SLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDA-LCMENRYLQ 224
+ H L+ ++ D+K E + Q + L + + HE + L E +LQ
Sbjct: 660 NETHTLE---KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
Query: 225 ERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGC 284
E+L+ HE LK+ + + + + ER + + + G+ L + H
Sbjct: 717 EKLRLQHEME--LKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE------LEQFH-- 766
Query: 285 SLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLW 344
+ ++ L T E + K ++ +HQR+ + G E E RT ++ +
Sbjct: 767 -----QEQLTSLVEKHTLEKEEL-RKELLEKHQRELQE--GREKMETECNRRTSQIEAQF 818
Query: 345 SLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAEAL 404
K T R R L EQ E K+ E +K E + CA A+ L
Sbjct: 819 QSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKS---QWEFEKDELTQECAEAQEL 875
Score = 36.6 bits (83), Expect = 0.058
Identities = 60/312 (19%), Positives = 122/312 (39%), Gaps = 28/312 (8%)
Query: 38 ILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRD 97
++++E QE ++ + M + ++K R+L + +L P+ +K N + +
Sbjct: 1844 LMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQL---ESNLLPKHQKHLNPSGTMNP 1900
Query: 98 SQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQL 157
++ L E + Q+ + + K+ +M +Q L E I + E E L ++
Sbjct: 1901 TEQEKLSLKRECDQFQKE--QSPANRKVSQMNSLEQEL--ETIHL------ENEGLKKKQ 1950
Query: 158 ERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALC 217
+ EQ+ ++H + S + ++ L Q+ ++ + + L
Sbjct: 1951 VKLDEQLMEMQHLRSTATPS-------PSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQ 2003
Query: 218 ME--NRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQ 275
E N++LQE L+ E N + N + +E R Q L L ++V
Sbjct: 2004 AERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQ----KLKLVKRLLQEKVN 2059
Query: 276 DLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKL 335
L ++ C + DL LL+ + + + N +L ++A L +
Sbjct: 2060 QL--KEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSNIV 2117
Query: 336 RTLEVSGLWSLP 347
R L + L S P
Sbjct: 2118 RNLTPAPLTSTP 2129
>gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo
sapiens]
Length = 693
Score = 57.4 bits (137), Expect = 3e-08
Identities = 104/509 (20%), Positives = 201/509 (39%), Gaps = 68/509 (13%)
Query: 20 SEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDP 79
S+Y LES + L++ +++ +Q++ Q + + ++ + + K E ++
Sbjct: 69 SQYQELAVALESSSVTISQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMERLETIN 128
Query: 80 SLPPEKRKQANLAQLLRDSQDRNKHLGEEIKE----LQQRLGEVQGDNKLLRMTIAKQRL 135
L EK A+L L ++ +H EE K+ LQ L +Q + L +Q+
Sbjct: 129 ILTLEK---ADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQRIQELERALCAVSTQQQE 185
Query: 136 GDEAIGVRHFAAHER-EDLVQQ---LERAKEQIESLEHDLQASVDE-LQDVKEERSSYQD 190
D + R H R + +++ L Q+ +Q DE + +K ER+ +Q+
Sbjct: 186 EDRSSSCREAVLHRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQE 245
Query: 191 KVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNAL-E 249
++ +++ E + E + D+ + R L E Q+ + +L + L +
Sbjct: 246 RMWKMSVEARTL---KEEKKRDIHRIQELERSLSELKNQMAKPPSLAPPAVTSVVEQLQD 302
Query: 250 RRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHE 309
K+ + + + L + Q LLS++ L + + + + E + E
Sbjct: 303 EAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEVQRVREQERLCE 362
Query: 310 KNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSP 369
+N ++ Q++T + G R+ + E++LR E + +R +
Sbjct: 363 QNERLREQQKTLQEQGERLRKQEQRLRKQE-----------------ERLRKEEERLQKQ 405
Query: 370 LLKFVEQPTENKADPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKL 429
+ +Q E + K+ QKQEE + + L Q QC
Sbjct: 406 EKRLWDQ--EERLWKKEERLQKQEERLALSQNHKLD--------------KQLAEPQC-- 447
Query: 430 FHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIE-----GQRSETGPAPPG 484
S E++N+ + ++L EQ EL+E E +E Q+ ET +
Sbjct: 448 ---------SFEDLNNEKKSALQL--EQQVKELQEKLDEEHLEAASQQNQQLETQLSLVA 496
Query: 485 LAIQGELPKSHLDSFEASRPAAKASTPED 513
L +G+ HLDS E P + PED
Sbjct: 497 LPGEGD-GGQHLDSEEEEAPRPTPNIPED 524
Score = 49.7 bits (117), Expect = 7e-06
Identities = 88/409 (21%), Positives = 160/409 (39%), Gaps = 54/409 (13%)
Query: 12 ESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKY 71
E + + L ++++ + AL +S T QQE D+ + R K
Sbjct: 152 EEESKDLAGRLQYSLQRIQELERALCAVS----TQQQEEDRSSSCREAVLHRRLQQTIKE 207
Query: 72 RELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLR---- 127
R L++ + E KQ QL RD + KH+ E Q+R+ ++ + + L+
Sbjct: 208 RALLNAHVTQVTESLKQV---QLERD--EYAKHIKGERARWQERMWKMSVEARTLKEEKK 262
Query: 128 --------MTIAKQRLGDEAIGVRHFAAHEREDLVQQLE----RAKEQIESLEHDLQASV 175
+ + L ++ A +V+QL+ ++++E LE LQ+ V
Sbjct: 263 RDIHRIQELERSLSELKNQMAKPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQV 322
Query: 176 DELQDV----KEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLH 231
+ Q + KE++ Q++ E L ++ R+ + + LC +N L+E+ K L
Sbjct: 323 ENNQALSLLSKEQKQRLQEQEEMLREQ-------EVQRVREQERLCEQNERLREQQKTLQ 375
Query: 232 EEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGV----------LSAKQVQDLLSED 281
E+ L+ + + ER + + + + L L ++ + LS++
Sbjct: 376 EQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQN 435
Query: 282 HGCSLP-ATPQ-SISDL---KSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLR 336
H A PQ S DL K A L + + E + + N+ E + L
Sbjct: 436 HKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEHLEAASQQNQQLETQLSLV 495
Query: 337 TL--EVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKAD 383
L E G L ++ P +P SR F++ P E KAD
Sbjct: 496 ALPGEGDGGQHLDSEEEEAPRPTPNIPEDLESREATSSFMDLPKE-KAD 543
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 57.0 bits (136), Expect = 4e-08
Identities = 121/556 (21%), Positives = 208/556 (37%), Gaps = 100/556 (17%)
Query: 2 EEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELD-TCQQERDQYKLMANQL 60
EE+A N + ++ + ++SE V +K E ++ L L ++L+ +Q + Q+
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 61 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRD---------------------SQ 99
E L KK EL L E ++ N + +R+ ++
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 100 DRNKHLGEEIK----ELQQRLGEVQGDNKL-----LRMTIAKQRLGDEAIG-------VR 143
+ + LGEE++ EL+ L +L +T+ K+ L +E +R
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198
Query: 144 HFAAHEREDLVQQLE-------------------------------RAKEQIESLEHDLQ 172
A E+L +QLE +AK+++E + L+
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 173 ASVDELQ----DVKEERSSYQDKVERLNQELNHI---LSGHENRII----DVDALCMENR 221
A V ELQ D + R+ DKV +L E+ + L+ E + I DV +L +
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ-- 1316
Query: 222 YLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSED 281
LQ+ + L EE K N++ LE +N S L + AKQ +
Sbjct: 1317 -LQDTQELLQEETR-QKLNVSTKLRQLEEERN------SLQDQLDEEMEAKQNLERHIST 1368
Query: 282 HGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVS 341
L + + + D S AL E I++ Q + +LEK L+
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ-Q 1427
Query: 342 GLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAA 401
L L D L QR LL + + AD +D + E E+ A +
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487
Query: 402 EALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAE 461
A E A+ + R N K+ + L S ++ +G+ + +L K + A E
Sbjct: 1488 LARALEE-----ALEAKEELERTN--KMLKAEMEDLVSSKD--DVGKNVHELEKSKRALE 1538
Query: 462 LEEVRRESPIEGQRSE 477
+ ++ +E E
Sbjct: 1539 TQMEEMKTQLEELEDE 1554
Score = 55.1 bits (131), Expect = 2e-07
Identities = 95/424 (22%), Positives = 178/424 (41%), Gaps = 53/424 (12%)
Query: 2 EEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLR 61
EE+ + ++ +++ + L +E + +L +KK+ L + E++ +E + QL+
Sbjct: 887 EEKNLLQEQLQAETE-LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEED---RGQQLQ 942
Query: 62 ERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQG 121
KK ++++D + L E+ + L ++ + K L +EI + + ++
Sbjct: 943 AER---KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 999
Query: 122 DNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDV 181
+ KLL ++R+ D + E E+ + L + K + ES+ +L E++
Sbjct: 1000 ERKLL-----EERISDLTTNLA-----EEEEKAKNLTKLKNKHESMISEL-----EVRLK 1044
Query: 182 KEERSSYQDKVERLNQELNHILSGHENRIIDVDALCME-NRYLQERLKQLHEEVNLLKSN 240
KEE+S + ++E+L ++L S +I D+ A E L ++ ++L + L
Sbjct: 1045 KEEKS--RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102
Query: 241 IAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISD-LKSL 299
IA+ NAL++ + +G L +A+ + D G L A + D L S
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162
Query: 300 AT-----------------ALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSG 342
AT AL E +Q RQ + V EL ++L + +
Sbjct: 1163 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH---AQAVEELTEQLEQFKRAK 1219
Query: 343 LWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAE 402
+L K T+ + L R +L +Q E+K K EAQ QE C+ E
Sbjct: 1220 A-NLDKNKQTLEKENADLAGELR----VLGQAKQEVEHK--KKKLEAQVQELQSKCSDGE 1272
Query: 403 ALTA 406
A
Sbjct: 1273 RARA 1276
Score = 50.1 bits (118), Expect = 5e-06
Identities = 87/374 (23%), Positives = 153/374 (40%), Gaps = 63/374 (16%)
Query: 19 VSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGD 78
V E KR LE++ E + +EL+ Q + KL +L Q+LK ++ +
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL---RLEVNMQALKGQFERDLQAR 1583
Query: 79 PSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLG---EVQGDNKLLRMTIAKQRL 135
EKR+Q L R + L +E K+ +++GD K L +
Sbjct: 1584 DEQNEEKRRQ-----LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638
Query: 136 G-DEAIGVRHFAAHEREDLVQQLERAK--------------EQIESLEHDLQASVDEL-- 178
G +EAI + +D ++LE A+ ++ +SLE DL ++L
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 179 ------------QDVKEE-------RSSYQDKVERLNQELNHILSGHENRIIDVDALCME 219
+++ EE R++ QD+ RL + + E +++A+
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1758
Query: 220 NRYLQERLKQLHEEVNLLKSNIAKYKNA---LERRKNS--------KGQGKSSSSALTGV 268
R ++ +QL E+ +S K ++A LER+ +G KS +
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 269 LSAK--QVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGN 326
L AK Q+++ + ++ AT K L LL+ E+ M Q++ Q K GN
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK--GN 1876
Query: 327 -RVAELEKKLRTLE 339
RV +L+++L E
Sbjct: 1877 ARVKQLKRQLEEAE 1890
Score = 46.2 bits (108), Expect = 7e-05
Identities = 86/427 (20%), Positives = 176/427 (41%), Gaps = 58/427 (13%)
Query: 95 LRDSQDRNKHLGEEIKELQQRLGEVQGDNKLL-------------------RMTIAKQRL 135
L+ +++R + E+KEL+Q+ ++ + LL R+ KQ L
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 920
Query: 136 GDEAIGVRHFAAHEREDLVQQL--ERAK--EQIESLEHDLQASVDELQDVKEERSSYQDK 191
+E + E ED QQL ER K +Q+ LE L+ Q ++ E+ + + K
Sbjct: 921 -EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 979
Query: 192 VERLNQEL------NHILSGH----ENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNI 241
+++L E+ N+ LS E RI D+ E +E+ K L + N +S I
Sbjct: 980 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE---EEKAKNLTKLKNKHESMI 1036
Query: 242 AKYKNALERRKNSKGQGKSSSSALTGVLS--AKQVQDLLSEDHGCSLPATPQSISDLKSL 299
++ + L++ + S+ + + L G S +Q+ DL ++ + + +L++
Sbjct: 1037 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE-EELQAA 1095
Query: 300 ATALLETIHEKNMVIQHQRQTNKILGNRVAEL----------EKKLRTLEVSGLWSLPGG 349
L + I +KN ++ R+ + + +L EK+ R L L +L
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG-EELEALKTE 1154
Query: 350 KDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAEALTAPED 409
+ L S T + R + +++ + + + + Q+ + + A E E
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 410 AGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRES 469
R N N+ + L E V ++ ++ K++ A+++E++ +
Sbjct: 1215 FKRAKANLDKNK------QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1268
Query: 470 PIEGQRS 476
+G+R+
Sbjct: 1269 S-DGERA 1274
Score = 44.7 bits (104), Expect = 2e-04
Identities = 85/454 (18%), Positives = 170/454 (37%), Gaps = 70/454 (15%)
Query: 27 RKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKR 86
++ E K A L K + QQE D + + R+ +L+KK R+ D L EK
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF---DQLLAEEKN 1462
Query: 87 KQANLAQL-------LRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEA 139
+ A R+ + + L ++E + E++ NK+L+ + +
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 140 IGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQEL 199
+G V +LE++K +E+ +++ ++EL+D E + +D RL
Sbjct: 1523 VGKN----------VHELEKSKRALETQMEEMKTQLEELED---ELQATEDAKLRL---- 1565
Query: 200 NHILSGHENRIIDVDALCMENRYLQERLKQLHEEVN-----LLKSNIAKYKNALERRKNS 254
+V+ ++ ++ ER Q +E N L+ + +Y+ LE +
Sbjct: 1566 ------------EVNMQALKGQF--ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Query: 255 KGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVI 314
+ ++ L G L ++Q ++ ++I L+ L + + E +
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQ------ADSAIKGREEAIKQLRKLQAQMKDFQRE----L 1661
Query: 315 QHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFV 374
+ R + + E EKK ++LE ++ L + +R+R
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEAD-----------LMQLQEDLAAAERARKQADLEK 1710
Query: 375 EQPTENKADPKDGEAQKQEEDESCAAAEAL---TAPEDAGRPAVNSPANQSRGNQCKLFH 431
E+ E A G Q+E A A E+ G S + Q +
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770
Query: 432 PSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEV 465
L S + N R+ ++ ++ ++L E+
Sbjct: 1771 NELATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Score = 40.0 bits (92), Expect = 0.005
Identities = 73/348 (20%), Positives = 141/348 (40%), Gaps = 52/348 (14%)
Query: 163 QIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRY 222
Q+ E ++QA DELQ KE + +++++ L Q+ + L E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ--------------LTEEKNL 891
Query: 223 LQERLK---QLHEEVNLLKSNIAKYKNALE--------RRKNSKGQGKSSSSALTGVLSA 271
LQE+L+ +L+ E ++ +A K LE R + + +G+ + + A
Sbjct: 892 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM--A 949
Query: 272 KQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQR----QTNKILGNR 327
+Q+ DL E+ A Q + K A A ++ + ++ +V+ Q + K+L R
Sbjct: 950 QQMLDL--EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 328 VAELEKKLRTLE--VSGLWSLPGGKDTILFS-DPTLPSGQRSRSPLLK-----------F 373
+++L L E L L ++++ + L ++SR L K F
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 374 VEQPTENKADPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGN----QCKL 429
EQ + +A + + Q +++E AA A E A + + G+ Q L
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 430 FHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIEGQRSE 477
+ +E++ LG E+ L K + L+ + + +R +
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEAL-KTELEDTLDSTATQQELRAKREQ 1174
Score = 32.3 bits (72), Expect = 1.1
Identities = 24/91 (26%), Positives = 46/91 (50%), Gaps = 7/91 (7%)
Query: 26 KRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEK 85
K+K + KE LL + E ++ +QYK A + R + LK++ E + + +
Sbjct: 1845 KQKDKKLKEILLQVEDE----RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1900
Query: 86 RKQANLAQLLRDSQDRNKHLGEEIKELQQRL 116
RK L + L ++ + N+ +G E+ L+ +L
Sbjct: 1901 RK---LQRELDEATESNEAMGREVNALKSKL 1928
Score = 30.8 bits (68), Expect = 3.2
Identities = 35/170 (20%), Positives = 68/170 (40%), Gaps = 33/170 (19%)
Query: 47 QQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLG 106
QQ Q K + ++L E ++K K++ I + + +Q Q R+ Q K L
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE--QEAREKQAATKSLK 1845
Query: 107 EEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIES 166
++ K+L++ L +V+ + K+ E+ KEQ E
Sbjct: 1846 QKDKKLKEILLQVEDERKMA-------------------------------EQYKEQAEK 1874
Query: 167 LEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDAL 216
++ +L++ +EE +L +EL+ +E +V+AL
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1924
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 57.0 bits (136), Expect = 4e-08
Identities = 121/556 (21%), Positives = 208/556 (37%), Gaps = 100/556 (17%)
Query: 2 EEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELD-TCQQERDQYKLMANQL 60
EE+A N + ++ + ++SE V +K E ++ L L ++L+ +Q + Q+
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085
Query: 61 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRD---------------------SQ 99
E L KK EL L E ++ N + +R+ ++
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
Query: 100 DRNKHLGEEIK----ELQQRLGEVQGDNKL-----LRMTIAKQRLGDEAIG-------VR 143
+ + LGEE++ EL+ L +L +T+ K+ L +E +R
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205
Query: 144 HFAAHEREDLVQQLE-------------------------------RAKEQIESLEHDLQ 172
A E+L +QLE +AK+++E + L+
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265
Query: 173 ASVDELQ----DVKEERSSYQDKVERLNQELNHI---LSGHENRII----DVDALCMENR 221
A V ELQ D + R+ DKV +L E+ + L+ E + I DV +L +
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ-- 1323
Query: 222 YLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSED 281
LQ+ + L EE K N++ LE +N S L + AKQ +
Sbjct: 1324 -LQDTQELLQEETR-QKLNVSTKLRQLEEERN------SLQDQLDEEMEAKQNLERHIST 1375
Query: 282 HGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVS 341
L + + + D S AL E I++ Q + +LEK L+
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ-Q 1434
Query: 342 GLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAA 401
L L D L QR LL + + AD +D + E E+ A +
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494
Query: 402 EALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAE 461
A E A+ + R N K+ + L S ++ +G+ + +L K + A E
Sbjct: 1495 LARALEE-----ALEAKEELERTN--KMLKAEMEDLVSSKD--DVGKNVHELEKSKRALE 1545
Query: 462 LEEVRRESPIEGQRSE 477
+ ++ +E E
Sbjct: 1546 TQMEEMKTQLEELEDE 1561
Score = 55.1 bits (131), Expect = 2e-07
Identities = 95/424 (22%), Positives = 178/424 (41%), Gaps = 53/424 (12%)
Query: 2 EEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLR 61
EE+ + ++ +++ + L +E + +L +KK+ L + E++ +E + QL+
Sbjct: 894 EEKNLLQEQLQAETE-LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEED---RGQQLQ 949
Query: 62 ERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQG 121
KK ++++D + L E+ + L ++ + K L +EI + + ++
Sbjct: 950 AER---KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 1006
Query: 122 DNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDV 181
+ KLL ++R+ D + E E+ + L + K + ES+ +L E++
Sbjct: 1007 ERKLL-----EERISDLTTNLA-----EEEEKAKNLTKLKNKHESMISEL-----EVRLK 1051
Query: 182 KEERSSYQDKVERLNQELNHILSGHENRIIDVDALCME-NRYLQERLKQLHEEVNLLKSN 240
KEE+S + ++E+L ++L S +I D+ A E L ++ ++L + L
Sbjct: 1052 KEEKS--RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109
Query: 241 IAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISD-LKSL 299
IA+ NAL++ + +G L +A+ + D G L A + D L S
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169
Query: 300 AT-----------------ALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSG 342
AT AL E +Q RQ + V EL ++L + +
Sbjct: 1170 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH---AQAVEELTEQLEQFKRAK 1226
Query: 343 LWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAE 402
+L K T+ + L R +L +Q E+K K EAQ QE C+ E
Sbjct: 1227 A-NLDKNKQTLEKENADLAGELR----VLGQAKQEVEHK--KKKLEAQVQELQSKCSDGE 1279
Query: 403 ALTA 406
A
Sbjct: 1280 RARA 1283
Score = 50.1 bits (118), Expect = 5e-06
Identities = 87/374 (23%), Positives = 153/374 (40%), Gaps = 63/374 (16%)
Query: 19 VSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGD 78
V E KR LE++ E + +EL+ Q + KL +L Q+LK ++ +
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL---RLEVNMQALKGQFERDLQAR 1590
Query: 79 PSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLG---EVQGDNKLLRMTIAKQRL 135
EKR+Q L R + L +E K+ +++GD K L +
Sbjct: 1591 DEQNEEKRRQ-----LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645
Query: 136 G-DEAIGVRHFAAHEREDLVQQLERAK--------------EQIESLEHDLQASVDEL-- 178
G +EAI + +D ++LE A+ ++ +SLE DL ++L
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 179 ------------QDVKEE-------RSSYQDKVERLNQELNHILSGHENRIIDVDALCME 219
+++ EE R++ QD+ RL + + E +++A+
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1765
Query: 220 NRYLQERLKQLHEEVNLLKSNIAKYKNA---LERRKNS--------KGQGKSSSSALTGV 268
R ++ +QL E+ +S K ++A LER+ +G KS +
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 269 LSAK--QVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGN 326
L AK Q+++ + ++ AT K L LL+ E+ M Q++ Q K GN
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK--GN 1883
Query: 327 -RVAELEKKLRTLE 339
RV +L+++L E
Sbjct: 1884 ARVKQLKRQLEEAE 1897
Score = 46.2 bits (108), Expect = 7e-05
Identities = 86/427 (20%), Positives = 176/427 (41%), Gaps = 58/427 (13%)
Query: 95 LRDSQDRNKHLGEEIKELQQRLGEVQGDNKLL-------------------RMTIAKQRL 135
L+ +++R + E+KEL+Q+ ++ + LL R+ KQ L
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 927
Query: 136 GDEAIGVRHFAAHEREDLVQQL--ERAK--EQIESLEHDLQASVDELQDVKEERSSYQDK 191
+E + E ED QQL ER K +Q+ LE L+ Q ++ E+ + + K
Sbjct: 928 -EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 986
Query: 192 VERLNQEL------NHILSGH----ENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNI 241
+++L E+ N+ LS E RI D+ E +E+ K L + N +S I
Sbjct: 987 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE---EEKAKNLTKLKNKHESMI 1043
Query: 242 AKYKNALERRKNSKGQGKSSSSALTGVLS--AKQVQDLLSEDHGCSLPATPQSISDLKSL 299
++ + L++ + S+ + + L G S +Q+ DL ++ + + +L++
Sbjct: 1044 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE-EELQAA 1102
Query: 300 ATALLETIHEKNMVIQHQRQTNKILGNRVAEL----------EKKLRTLEVSGLWSLPGG 349
L + I +KN ++ R+ + + +L EK+ R L L +L
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG-EELEALKTE 1161
Query: 350 KDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAEALTAPED 409
+ L S T + R + +++ + + + + Q+ + + A E E
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 410 AGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRES 469
R N N+ + L E V ++ ++ K++ A+++E++ +
Sbjct: 1222 FKRAKANLDKNK------QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1275
Query: 470 PIEGQRS 476
+G+R+
Sbjct: 1276 S-DGERA 1281
Score = 44.7 bits (104), Expect = 2e-04
Identities = 85/454 (18%), Positives = 170/454 (37%), Gaps = 70/454 (15%)
Query: 27 RKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKR 86
++ E K A L K + QQE D + + R+ +L+KK R+ D L EK
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF---DQLLAEEKN 1469
Query: 87 KQANLAQL-------LRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEA 139
+ A R+ + + L ++E + E++ NK+L+ + +
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529
Query: 140 IGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQEL 199
+G V +LE++K +E+ +++ ++EL+D E + +D RL
Sbjct: 1530 VGKN----------VHELEKSKRALETQMEEMKTQLEELED---ELQATEDAKLRL---- 1572
Query: 200 NHILSGHENRIIDVDALCMENRYLQERLKQLHEEVN-----LLKSNIAKYKNALERRKNS 254
+V+ ++ ++ ER Q +E N L+ + +Y+ LE +
Sbjct: 1573 ------------EVNMQALKGQF--ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Query: 255 KGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVI 314
+ ++ L G L ++Q ++ ++I L+ L + + E +
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQ------ADSAIKGREEAIKQLRKLQAQMKDFQRE----L 1668
Query: 315 QHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFV 374
+ R + + E EKK ++LE ++ L + +R+R
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEAD-----------LMQLQEDLAAAERARKQADLEK 1717
Query: 375 EQPTENKADPKDGEAQKQEEDESCAAAEAL---TAPEDAGRPAVNSPANQSRGNQCKLFH 431
E+ E A G Q+E A A E+ G S + Q +
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777
Query: 432 PSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEV 465
L S + N R+ ++ ++ ++L E+
Sbjct: 1778 NELATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Score = 40.0 bits (92), Expect = 0.005
Identities = 73/348 (20%), Positives = 141/348 (40%), Gaps = 52/348 (14%)
Query: 163 QIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRY 222
Q+ E ++QA DELQ KE + +++++ L Q+ + L E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ--------------LTEEKNL 898
Query: 223 LQERLK---QLHEEVNLLKSNIAKYKNALE--------RRKNSKGQGKSSSSALTGVLSA 271
LQE+L+ +L+ E ++ +A K LE R + + +G+ + + A
Sbjct: 899 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM--A 956
Query: 272 KQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQR----QTNKILGNR 327
+Q+ DL E+ A Q + K A A ++ + ++ +V+ Q + K+L R
Sbjct: 957 QQMLDL--EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 328 VAELEKKLRTLE--VSGLWSLPGGKDTILFS-DPTLPSGQRSRSPLLK-----------F 373
+++L L E L L ++++ + L ++SR L K F
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 374 VEQPTENKADPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGN----QCKL 429
EQ + +A + + Q +++E AA A E A + + G+ Q L
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 430 FHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIEGQRSE 477
+ +E++ LG E+ L K + L+ + + +R +
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEAL-KTELEDTLDSTATQQELRAKREQ 1181
Score = 32.3 bits (72), Expect = 1.1
Identities = 24/91 (26%), Positives = 46/91 (50%), Gaps = 7/91 (7%)
Query: 26 KRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEK 85
K+K + KE LL + E ++ +QYK A + R + LK++ E + + +
Sbjct: 1852 KQKDKKLKEILLQVEDE----RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1907
Query: 86 RKQANLAQLLRDSQDRNKHLGEEIKELQQRL 116
RK L + L ++ + N+ +G E+ L+ +L
Sbjct: 1908 RK---LQRELDEATESNEAMGREVNALKSKL 1935
Score = 30.8 bits (68), Expect = 3.2
Identities = 35/170 (20%), Positives = 68/170 (40%), Gaps = 33/170 (19%)
Query: 47 QQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLG 106
QQ Q K + ++L E ++K K++ I + + +Q Q R+ Q K L
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE--QEAREKQAATKSLK 1852
Query: 107 EEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIES 166
++ K+L++ L +V+ + K+ E+ KEQ E
Sbjct: 1853 QKDKKLKEILLQVEDERKMA-------------------------------EQYKEQAEK 1881
Query: 167 LEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDAL 216
++ +L++ +EE +L +EL+ +E +V+AL
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1931
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 57.0 bits (136), Expect = 4e-08
Identities = 121/556 (21%), Positives = 208/556 (37%), Gaps = 100/556 (17%)
Query: 2 EEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELD-TCQQERDQYKLMANQL 60
EE+A N + ++ + ++SE V +K E ++ L L ++L+ +Q + Q+
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085
Query: 61 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRD---------------------SQ 99
E L KK EL L E ++ N + +R+ ++
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
Query: 100 DRNKHLGEEIK----ELQQRLGEVQGDNKL-----LRMTIAKQRLGDEAIG-------VR 143
+ + LGEE++ EL+ L +L +T+ K+ L +E +R
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205
Query: 144 HFAAHEREDLVQQLE-------------------------------RAKEQIESLEHDLQ 172
A E+L +QLE +AK+++E + L+
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265
Query: 173 ASVDELQ----DVKEERSSYQDKVERLNQELNHI---LSGHENRII----DVDALCMENR 221
A V ELQ D + R+ DKV +L E+ + L+ E + I DV +L +
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ-- 1323
Query: 222 YLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSED 281
LQ+ + L EE K N++ LE +N S L + AKQ +
Sbjct: 1324 -LQDTQELLQEETR-QKLNVSTKLRQLEEERN------SLQDQLDEEMEAKQNLERHIST 1375
Query: 282 HGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVS 341
L + + + D S AL E I++ Q + +LEK L+
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ-Q 1434
Query: 342 GLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAA 401
L L D L QR LL + + AD +D + E E+ A +
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494
Query: 402 EALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAE 461
A E A+ + R N K+ + L S ++ +G+ + +L K + A E
Sbjct: 1495 LARALEE-----ALEAKEELERTN--KMLKAEMEDLVSSKD--DVGKNVHELEKSKRALE 1545
Query: 462 LEEVRRESPIEGQRSE 477
+ ++ +E E
Sbjct: 1546 TQMEEMKTQLEELEDE 1561
Score = 55.1 bits (131), Expect = 2e-07
Identities = 95/424 (22%), Positives = 178/424 (41%), Gaps = 53/424 (12%)
Query: 2 EEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLR 61
EE+ + ++ +++ + L +E + +L +KK+ L + E++ +E + QL+
Sbjct: 894 EEKNLLQEQLQAETE-LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEED---RGQQLQ 949
Query: 62 ERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQG 121
KK ++++D + L E+ + L ++ + K L +EI + + ++
Sbjct: 950 AER---KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 1006
Query: 122 DNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDV 181
+ KLL ++R+ D + E E+ + L + K + ES+ +L E++
Sbjct: 1007 ERKLL-----EERISDLTTNLA-----EEEEKAKNLTKLKNKHESMISEL-----EVRLK 1051
Query: 182 KEERSSYQDKVERLNQELNHILSGHENRIIDVDALCME-NRYLQERLKQLHEEVNLLKSN 240
KEE+S + ++E+L ++L S +I D+ A E L ++ ++L + L
Sbjct: 1052 KEEKS--RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109
Query: 241 IAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISD-LKSL 299
IA+ NAL++ + +G L +A+ + D G L A + D L S
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169
Query: 300 AT-----------------ALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSG 342
AT AL E +Q RQ + V EL ++L + +
Sbjct: 1170 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH---AQAVEELTEQLEQFKRAK 1226
Query: 343 LWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAE 402
+L K T+ + L R +L +Q E+K K EAQ QE C+ E
Sbjct: 1227 A-NLDKNKQTLEKENADLAGELR----VLGQAKQEVEHK--KKKLEAQVQELQSKCSDGE 1279
Query: 403 ALTA 406
A
Sbjct: 1280 RARA 1283
Score = 50.1 bits (118), Expect = 5e-06
Identities = 87/374 (23%), Positives = 153/374 (40%), Gaps = 63/374 (16%)
Query: 19 VSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGD 78
V E KR LE++ E + +EL+ Q + KL +L Q+LK ++ +
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL---RLEVNMQALKGQFERDLQAR 1590
Query: 79 PSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLG---EVQGDNKLLRMTIAKQRL 135
EKR+Q L R + L +E K+ +++GD K L +
Sbjct: 1591 DEQNEEKRRQ-----LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645
Query: 136 G-DEAIGVRHFAAHEREDLVQQLERAK--------------EQIESLEHDLQASVDEL-- 178
G +EAI + +D ++LE A+ ++ +SLE DL ++L
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 179 ------------QDVKEE-------RSSYQDKVERLNQELNHILSGHENRIIDVDALCME 219
+++ EE R++ QD+ RL + + E +++A+
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1765
Query: 220 NRYLQERLKQLHEEVNLLKSNIAKYKNA---LERRKNS--------KGQGKSSSSALTGV 268
R ++ +QL E+ +S K ++A LER+ +G KS +
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 269 LSAK--QVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGN 326
L AK Q+++ + ++ AT K L LL+ E+ M Q++ Q K GN
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK--GN 1883
Query: 327 -RVAELEKKLRTLE 339
RV +L+++L E
Sbjct: 1884 ARVKQLKRQLEEAE 1897
Score = 46.2 bits (108), Expect = 7e-05
Identities = 86/427 (20%), Positives = 176/427 (41%), Gaps = 58/427 (13%)
Query: 95 LRDSQDRNKHLGEEIKELQQRLGEVQGDNKLL-------------------RMTIAKQRL 135
L+ +++R + E+KEL+Q+ ++ + LL R+ KQ L
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 927
Query: 136 GDEAIGVRHFAAHEREDLVQQL--ERAK--EQIESLEHDLQASVDELQDVKEERSSYQDK 191
+E + E ED QQL ER K +Q+ LE L+ Q ++ E+ + + K
Sbjct: 928 -EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 986
Query: 192 VERLNQEL------NHILSGH----ENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNI 241
+++L E+ N+ LS E RI D+ E +E+ K L + N +S I
Sbjct: 987 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE---EEKAKNLTKLKNKHESMI 1043
Query: 242 AKYKNALERRKNSKGQGKSSSSALTGVLS--AKQVQDLLSEDHGCSLPATPQSISDLKSL 299
++ + L++ + S+ + + L G S +Q+ DL ++ + + +L++
Sbjct: 1044 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE-EELQAA 1102
Query: 300 ATALLETIHEKNMVIQHQRQTNKILGNRVAEL----------EKKLRTLEVSGLWSLPGG 349
L + I +KN ++ R+ + + +L EK+ R L L +L
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG-EELEALKTE 1161
Query: 350 KDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAEALTAPED 409
+ L S T + R + +++ + + + + Q+ + + A E E
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 410 AGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRES 469
R N N+ + L E V ++ ++ K++ A+++E++ +
Sbjct: 1222 FKRAKANLDKNK------QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1275
Query: 470 PIEGQRS 476
+G+R+
Sbjct: 1276 S-DGERA 1281
Score = 44.7 bits (104), Expect = 2e-04
Identities = 85/454 (18%), Positives = 170/454 (37%), Gaps = 70/454 (15%)
Query: 27 RKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKR 86
++ E K A L K + QQE D + + R+ +L+KK R+ D L EK
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF---DQLLAEEKN 1469
Query: 87 KQANLAQL-------LRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEA 139
+ A R+ + + L ++E + E++ NK+L+ + +
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529
Query: 140 IGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQEL 199
+G V +LE++K +E+ +++ ++EL+D E + +D RL
Sbjct: 1530 VGKN----------VHELEKSKRALETQMEEMKTQLEELED---ELQATEDAKLRL---- 1572
Query: 200 NHILSGHENRIIDVDALCMENRYLQERLKQLHEEVN-----LLKSNIAKYKNALERRKNS 254
+V+ ++ ++ ER Q +E N L+ + +Y+ LE +
Sbjct: 1573 ------------EVNMQALKGQF--ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Query: 255 KGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVI 314
+ ++ L G L ++Q ++ ++I L+ L + + E +
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQ------ADSAIKGREEAIKQLRKLQAQMKDFQRE----L 1668
Query: 315 QHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFV 374
+ R + + E EKK ++LE ++ L + +R+R
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEAD-----------LMQLQEDLAAAERARKQADLEK 1717
Query: 375 EQPTENKADPKDGEAQKQEEDESCAAAEAL---TAPEDAGRPAVNSPANQSRGNQCKLFH 431
E+ E A G Q+E A A E+ G S + Q +
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777
Query: 432 PSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEV 465
L S + N R+ ++ ++ ++L E+
Sbjct: 1778 NELATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Score = 40.0 bits (92), Expect = 0.005
Identities = 73/348 (20%), Positives = 141/348 (40%), Gaps = 52/348 (14%)
Query: 163 QIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRY 222
Q+ E ++QA DELQ KE + +++++ L Q+ + L E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ--------------LTEEKNL 898
Query: 223 LQERLK---QLHEEVNLLKSNIAKYKNALE--------RRKNSKGQGKSSSSALTGVLSA 271
LQE+L+ +L+ E ++ +A K LE R + + +G+ + + A
Sbjct: 899 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM--A 956
Query: 272 KQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQR----QTNKILGNR 327
+Q+ DL E+ A Q + K A A ++ + ++ +V+ Q + K+L R
Sbjct: 957 QQMLDL--EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 328 VAELEKKLRTLE--VSGLWSLPGGKDTILFS-DPTLPSGQRSRSPLLK-----------F 373
+++L L E L L ++++ + L ++SR L K F
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 374 VEQPTENKADPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGN----QCKL 429
EQ + +A + + Q +++E AA A E A + + G+ Q L
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 430 FHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIEGQRSE 477
+ +E++ LG E+ L K + L+ + + +R +
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEAL-KTELEDTLDSTATQQELRAKREQ 1181
Score = 32.3 bits (72), Expect = 1.1
Identities = 24/91 (26%), Positives = 46/91 (50%), Gaps = 7/91 (7%)
Query: 26 KRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEK 85
K+K + KE LL + E ++ +QYK A + R + LK++ E + + +
Sbjct: 1852 KQKDKKLKEILLQVEDE----RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1907
Query: 86 RKQANLAQLLRDSQDRNKHLGEEIKELQQRL 116
RK L + L ++ + N+ +G E+ L+ +L
Sbjct: 1908 RK---LQRELDEATESNEAMGREVNALKSKL 1935
Score = 30.8 bits (68), Expect = 3.2
Identities = 35/170 (20%), Positives = 68/170 (40%), Gaps = 33/170 (19%)
Query: 47 QQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLG 106
QQ Q K + ++L E ++K K++ I + + +Q Q R+ Q K L
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE--QEAREKQAATKSLK 1852
Query: 107 EEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIES 166
++ K+L++ L +V+ + K+ E+ KEQ E
Sbjct: 1853 QKDKKLKEILLQVEDERKMA-------------------------------EQYKEQAEK 1881
Query: 167 LEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDAL 216
++ +L++ +EE +L +EL+ +E +V+AL
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1931
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 57.0 bits (136), Expect = 4e-08
Identities = 121/556 (21%), Positives = 208/556 (37%), Gaps = 100/556 (17%)
Query: 2 EEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELD-TCQQERDQYKLMANQL 60
EE+A N + ++ + ++SE V +K E ++ L L ++L+ +Q + Q+
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 61 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRD---------------------SQ 99
E L KK EL L E ++ N + +R+ ++
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 100 DRNKHLGEEIK----ELQQRLGEVQGDNKL-----LRMTIAKQRLGDEAIG-------VR 143
+ + LGEE++ EL+ L +L +T+ K+ L +E +R
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198
Query: 144 HFAAHEREDLVQQLE-------------------------------RAKEQIESLEHDLQ 172
A E+L +QLE +AK+++E + L+
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 173 ASVDELQ----DVKEERSSYQDKVERLNQELNHI---LSGHENRII----DVDALCMENR 221
A V ELQ D + R+ DKV +L E+ + L+ E + I DV +L +
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ-- 1316
Query: 222 YLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSED 281
LQ+ + L EE K N++ LE +N S L + AKQ +
Sbjct: 1317 -LQDTQELLQEETR-QKLNVSTKLRQLEEERN------SLQDQLDEEMEAKQNLERHIST 1368
Query: 282 HGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVS 341
L + + + D S AL E I++ Q + +LEK L+
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ-Q 1427
Query: 342 GLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAA 401
L L D L QR LL + + AD +D + E E+ A +
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487
Query: 402 EALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAE 461
A E A+ + R N K+ + L S ++ +G+ + +L K + A E
Sbjct: 1488 LARALEE-----ALEAKEELERTN--KMLKAEMEDLVSSKD--DVGKNVHELEKSKRALE 1538
Query: 462 LEEVRRESPIEGQRSE 477
+ ++ +E E
Sbjct: 1539 TQMEEMKTQLEELEDE 1554
Score = 55.1 bits (131), Expect = 2e-07
Identities = 95/424 (22%), Positives = 178/424 (41%), Gaps = 53/424 (12%)
Query: 2 EEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLR 61
EE+ + ++ +++ + L +E + +L +KK+ L + E++ +E + QL+
Sbjct: 887 EEKNLLQEQLQAETE-LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEED---RGQQLQ 942
Query: 62 ERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQG 121
KK ++++D + L E+ + L ++ + K L +EI + + ++
Sbjct: 943 AER---KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 999
Query: 122 DNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDV 181
+ KLL ++R+ D + E E+ + L + K + ES+ +L E++
Sbjct: 1000 ERKLL-----EERISDLTTNLA-----EEEEKAKNLTKLKNKHESMISEL-----EVRLK 1044
Query: 182 KEERSSYQDKVERLNQELNHILSGHENRIIDVDALCME-NRYLQERLKQLHEEVNLLKSN 240
KEE+S + ++E+L ++L S +I D+ A E L ++ ++L + L
Sbjct: 1045 KEEKS--RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102
Query: 241 IAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISD-LKSL 299
IA+ NAL++ + +G L +A+ + D G L A + D L S
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162
Query: 300 AT-----------------ALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSG 342
AT AL E +Q RQ + V EL ++L + +
Sbjct: 1163 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH---AQAVEELTEQLEQFKRAK 1219
Query: 343 LWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAE 402
+L K T+ + L R +L +Q E+K K EAQ QE C+ E
Sbjct: 1220 A-NLDKNKQTLEKENADLAGELR----VLGQAKQEVEHK--KKKLEAQVQELQSKCSDGE 1272
Query: 403 ALTA 406
A
Sbjct: 1273 RARA 1276
Score = 50.1 bits (118), Expect = 5e-06
Identities = 87/374 (23%), Positives = 153/374 (40%), Gaps = 63/374 (16%)
Query: 19 VSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGD 78
V E KR LE++ E + +EL+ Q + KL +L Q+LK ++ +
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL---RLEVNMQALKGQFERDLQAR 1583
Query: 79 PSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLG---EVQGDNKLLRMTIAKQRL 135
EKR+Q L R + L +E K+ +++GD K L +
Sbjct: 1584 DEQNEEKRRQ-----LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638
Query: 136 G-DEAIGVRHFAAHEREDLVQQLERAK--------------EQIESLEHDLQASVDEL-- 178
G +EAI + +D ++LE A+ ++ +SLE DL ++L
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 179 ------------QDVKEE-------RSSYQDKVERLNQELNHILSGHENRIIDVDALCME 219
+++ EE R++ QD+ RL + + E +++A+
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1758
Query: 220 NRYLQERLKQLHEEVNLLKSNIAKYKNA---LERRKNS--------KGQGKSSSSALTGV 268
R ++ +QL E+ +S K ++A LER+ +G KS +
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 269 LSAK--QVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGN 326
L AK Q+++ + ++ AT K L LL+ E+ M Q++ Q K GN
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK--GN 1876
Query: 327 -RVAELEKKLRTLE 339
RV +L+++L E
Sbjct: 1877 ARVKQLKRQLEEAE 1890
Score = 46.2 bits (108), Expect = 7e-05
Identities = 86/427 (20%), Positives = 176/427 (41%), Gaps = 58/427 (13%)
Query: 95 LRDSQDRNKHLGEEIKELQQRLGEVQGDNKLL-------------------RMTIAKQRL 135
L+ +++R + E+KEL+Q+ ++ + LL R+ KQ L
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 920
Query: 136 GDEAIGVRHFAAHEREDLVQQL--ERAK--EQIESLEHDLQASVDELQDVKEERSSYQDK 191
+E + E ED QQL ER K +Q+ LE L+ Q ++ E+ + + K
Sbjct: 921 -EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 979
Query: 192 VERLNQEL------NHILSGH----ENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNI 241
+++L E+ N+ LS E RI D+ E +E+ K L + N +S I
Sbjct: 980 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE---EEKAKNLTKLKNKHESMI 1036
Query: 242 AKYKNALERRKNSKGQGKSSSSALTGVLS--AKQVQDLLSEDHGCSLPATPQSISDLKSL 299
++ + L++ + S+ + + L G S +Q+ DL ++ + + +L++
Sbjct: 1037 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE-EELQAA 1095
Query: 300 ATALLETIHEKNMVIQHQRQTNKILGNRVAEL----------EKKLRTLEVSGLWSLPGG 349
L + I +KN ++ R+ + + +L EK+ R L L +L
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG-EELEALKTE 1154
Query: 350 KDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAEALTAPED 409
+ L S T + R + +++ + + + + Q+ + + A E E
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 410 AGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRES 469
R N N+ + L E V ++ ++ K++ A+++E++ +
Sbjct: 1215 FKRAKANLDKNK------QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1268
Query: 470 PIEGQRS 476
+G+R+
Sbjct: 1269 S-DGERA 1274
Score = 44.7 bits (104), Expect = 2e-04
Identities = 85/454 (18%), Positives = 170/454 (37%), Gaps = 70/454 (15%)
Query: 27 RKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKR 86
++ E K A L K + QQE D + + R+ +L+KK R+ D L EK
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF---DQLLAEEKN 1462
Query: 87 KQANLAQL-------LRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEA 139
+ A R+ + + L ++E + E++ NK+L+ + +
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 140 IGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQEL 199
+G V +LE++K +E+ +++ ++EL+D E + +D RL
Sbjct: 1523 VGKN----------VHELEKSKRALETQMEEMKTQLEELED---ELQATEDAKLRL---- 1565
Query: 200 NHILSGHENRIIDVDALCMENRYLQERLKQLHEEVN-----LLKSNIAKYKNALERRKNS 254
+V+ ++ ++ ER Q +E N L+ + +Y+ LE +
Sbjct: 1566 ------------EVNMQALKGQF--ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Query: 255 KGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVI 314
+ ++ L G L ++Q ++ ++I L+ L + + E +
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQ------ADSAIKGREEAIKQLRKLQAQMKDFQRE----L 1661
Query: 315 QHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFV 374
+ R + + E EKK ++LE ++ L + +R+R
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEAD-----------LMQLQEDLAAAERARKQADLEK 1710
Query: 375 EQPTENKADPKDGEAQKQEEDESCAAAEAL---TAPEDAGRPAVNSPANQSRGNQCKLFH 431
E+ E A G Q+E A A E+ G S + Q +
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770
Query: 432 PSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEV 465
L S + N R+ ++ ++ ++L E+
Sbjct: 1771 NELATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Score = 40.0 bits (92), Expect = 0.005
Identities = 73/348 (20%), Positives = 141/348 (40%), Gaps = 52/348 (14%)
Query: 163 QIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRY 222
Q+ E ++QA DELQ KE + +++++ L Q+ + L E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ--------------LTEEKNL 891
Query: 223 LQERLK---QLHEEVNLLKSNIAKYKNALE--------RRKNSKGQGKSSSSALTGVLSA 271
LQE+L+ +L+ E ++ +A K LE R + + +G+ + + A
Sbjct: 892 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM--A 949
Query: 272 KQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQR----QTNKILGNR 327
+Q+ DL E+ A Q + K A A ++ + ++ +V+ Q + K+L R
Sbjct: 950 QQMLDL--EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 328 VAELEKKLRTLE--VSGLWSLPGGKDTILFS-DPTLPSGQRSRSPLLK-----------F 373
+++L L E L L ++++ + L ++SR L K F
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 374 VEQPTENKADPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGN----QCKL 429
EQ + +A + + Q +++E AA A E A + + G+ Q L
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 430 FHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIEGQRSE 477
+ +E++ LG E+ L K + L+ + + +R +
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEAL-KTELEDTLDSTATQQELRAKREQ 1174
Score = 32.3 bits (72), Expect = 1.1
Identities = 24/91 (26%), Positives = 46/91 (50%), Gaps = 7/91 (7%)
Query: 26 KRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEK 85
K+K + KE LL + E ++ +QYK A + R + LK++ E + + +
Sbjct: 1845 KQKDKKLKEILLQVEDE----RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1900
Query: 86 RKQANLAQLLRDSQDRNKHLGEEIKELQQRL 116
RK L + L ++ + N+ +G E+ L+ +L
Sbjct: 1901 RK---LQRELDEATESNEAMGREVNALKSKL 1928
Score = 30.8 bits (68), Expect = 3.2
Identities = 35/170 (20%), Positives = 68/170 (40%), Gaps = 33/170 (19%)
Query: 47 QQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLG 106
QQ Q K + ++L E ++K K++ I + + +Q Q R+ Q K L
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE--QEAREKQAATKSLK 1845
Query: 107 EEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIES 166
++ K+L++ L +V+ + K+ E+ KEQ E
Sbjct: 1846 QKDKKLKEILLQVEDERKMA-------------------------------EQYKEQAEK 1874
Query: 167 LEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDAL 216
++ +L++ +EE +L +EL+ +E +V+AL
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1924
>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo
sapiens]
Length = 693
Score = 56.6 bits (135), Expect = 5e-08
Identities = 104/509 (20%), Positives = 201/509 (39%), Gaps = 68/509 (13%)
Query: 20 SEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDP 79
S+Y LES + L++ +++ +Q++ Q + + ++ + + K E ++
Sbjct: 69 SQYQELAVALESSSVTINQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMEQLETIN 128
Query: 80 SLPPEKRKQANLAQLLRDSQDRNKHLGEEIKE----LQQRLGEVQGDNKLLRMTIAKQRL 135
L EK A+L L ++ +H EE K+ LQ L +Q + L +Q+
Sbjct: 129 ILTLEK---ADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQHIQELERALCAVSTQQQE 185
Query: 136 GDEAIGVRHFAAHER-EDLVQQ---LERAKEQIESLEHDLQASVDE-LQDVKEERSSYQD 190
D + R R + +++ L Q+ +Q DE + +K ER+ +Q+
Sbjct: 186 EDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQE 245
Query: 191 KVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNAL-E 249
++ +++ E + E + D+ + R L E Q+ E +L + L +
Sbjct: 246 RMWKMSVEARTL---KEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQD 302
Query: 250 RRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHE 309
K+ + + + L + Q LLS++ L + + + ++ E + E
Sbjct: 303 EAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCE 362
Query: 310 KNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSP 369
+N ++ Q++T + G R+ + E++LR E + +R +
Sbjct: 363 QNERLREQQKTLQEQGERLRKQEQRLRKQE-----------------ERLRKEEERLQKQ 405
Query: 370 LLKFVEQPTENKADPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKL 429
+ +Q E + K+ QKQEE + + L Q QC
Sbjct: 406 EKRLWDQ--EERLWKKEERLQKQEERLALSQNHKLD--------------KQLAEPQC-- 447
Query: 430 FHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIE-----GQRSETGPAPPG 484
S E++N+ + ++L EQ EL+E E +E Q+ ET +
Sbjct: 448 ---------SFEDLNNEKKSALQL--EQQVKELQEKLDEEHLEAASQRNQQLETQLSLVA 496
Query: 485 LAIQGELPKSHLDSFEASRPAAKASTPED 513
L +G+ HLDS E P + PED
Sbjct: 497 LPGEGD-GGQHLDSEEEEAPRPTPNIPED 524
Score = 51.2 bits (121), Expect = 2e-06
Identities = 77/378 (20%), Positives = 148/378 (39%), Gaps = 50/378 (13%)
Query: 43 LDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRN 102
+ T QQE D+ + +R K R L++ + E KQ QL RD +
Sbjct: 179 VSTQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQV---QLERD--EYA 233
Query: 103 KHLGEEIKELQQRLGEVQGDNKLLR----------------MTIAKQRLGDEAIGVRHFA 146
KH+ E Q+R+ ++ + + L+ ++ K ++ +
Sbjct: 234 KHIKGERARWQERMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAV 293
Query: 147 AHEREDLVQQLERAKEQIESLEHDLQASVDELQDV----KEERSSYQDKVERLNQELNHI 202
E L + + ++++E LE LQ+ V+ Q + KE++ Q++ E L ++
Sbjct: 294 TSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQ---- 349
Query: 203 LSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSS 262
R+ + + LC +N L+E+ K L E+ L+ + + ER + + + +
Sbjct: 350 ---EAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQE 406
Query: 263 SALTGVLSA--KQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQT 320
L K+ + L ++ +L + L + + +EK +Q ++Q
Sbjct: 407 KRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQV 466
Query: 321 ----NKILGNRVAELEKKLRTLEVS-GLWSLPGGKDTILFSD----------PTLPSGQR 365
K+ + ++ + LE L +LPG D D P +P
Sbjct: 467 KELQEKLDEEHLEAASQRNQQLETQLSLVALPGEGDGGQHLDSEEEEAPRPTPNIPEDLE 526
Query: 366 SRSPLLKFVEQPTENKAD 383
SR F++ P E KAD
Sbjct: 527 SREATSSFMDLPKE-KAD 543
>gi|148612801 KIAA1009 protein [Homo sapiens]
Length = 1403
Score = 56.6 bits (135), Expect = 5e-08
Identities = 73/304 (24%), Positives = 141/304 (46%), Gaps = 44/304 (14%)
Query: 47 QQERD----QYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQD-R 101
QQE + Q K + Q ++ + + K+ + L SL + K L+Q++ DS+ R
Sbjct: 721 QQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTR 780
Query: 102 NKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAK 161
N++ + + EL R+ + + D+ L + KQ +A+ V + E + ++ ++AK
Sbjct: 781 NQNFTDLLAEL--RMAQKEKDSLLEDIKRLKQ--DKQALEV------DFEKMKKERDQAK 830
Query: 162 EQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENR 221
+QI + + ++L ++K +++ ++ RL + L E ++D DAL
Sbjct: 831 DQIAYV------TGEKLYEIKILEETHKQEISRLQKRLQWYAENQE--LLDKDAL----- 877
Query: 222 YLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDL---L 278
RL++ +EE+ LK I K K ++ + AK++QDL +
Sbjct: 878 ----RLREANEEIEKLKLEIEKLK-----AESGNPSIRQKIRLKDKAADAKKIQDLERQV 928
Query: 279 SEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKI---LGNRVAELEKKL 335
E G P S+ L A+A +T+ +KN V +++ K+ L + + +K L
Sbjct: 929 KEMEGILKRRYPNSLPALILAASAAGDTV-DKNTVEFMEKRIKKLEADLEGKDEDAKKSL 987
Query: 336 RTLE 339
RT+E
Sbjct: 988 RTME 991
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.127 0.346
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,427,165
Number of Sequences: 37866
Number of extensions: 1073895
Number of successful extensions: 9807
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 228
Number of HSP's successfully gapped in prelim test: 887
Number of HSP's that attempted gapping in prelim test: 5774
Number of HSP's gapped (non-prelim): 3189
length of query: 529
length of database: 18,247,518
effective HSP length: 107
effective length of query: 422
effective length of database: 14,195,856
effective search space: 5990651232
effective search space used: 5990651232
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.