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Search of human proteins with 194440719
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194440719 chondroadherin-like [Homo sapiens]
(762 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194440719 chondroadherin-like [Homo sapiens] 1536 0.0
gi|153251229 chondroadherin precursor [Homo sapiens] 255 1e-67
gi|225579152 insulin-like growth factor binding protein, acid la... 162 1e-39
gi|4826772 insulin-like growth factor binding protein, acid labi... 162 1e-39
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 147 4e-35
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 145 1e-34
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 142 2e-33
gi|198041768 synleurin [Homo sapiens] 136 6e-32
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] 136 6e-32
gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo s... 135 2e-31
gi|188528675 slit homolog 1 [Homo sapiens] 134 4e-31
gi|4759146 slit homolog 2 [Homo sapiens] 132 1e-30
gi|12007646 nyctalopin precursor [Homo sapiens] 132 2e-30
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor... 130 3e-30
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor... 130 3e-30
gi|13194201 reticulon 4 receptor precursor [Homo sapiens] 130 5e-30
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ... 130 5e-30
gi|88702793 slit-like 2 [Homo sapiens] 130 6e-30
gi|51317373 netrin-G1 ligand [Homo sapiens] 129 8e-30
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 128 2e-29
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 128 2e-29
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 128 2e-29
gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens] 128 2e-29
gi|40217825 slit and trk like 6 [Homo sapiens] 127 4e-29
gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens] 125 1e-28
gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens] 125 1e-28
gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens] 125 1e-28
gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens] 125 1e-28
gi|221136969 SLIT and NTRK-like family, member 2 [Homo sapiens] 125 1e-28
gi|221136965 SLIT and NTRK-like family, member 2 [Homo sapiens] 125 1e-28
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 1536 bits (3977), Expect = 0.0
Identities = 762/762 (100%), Positives = 762/762 (100%)
Query: 1 MEGPRSSTHVPLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAI 60
MEGPRSSTHVPLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAI
Sbjct: 1 MEGPRSSTHVPLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAI 60
Query: 61 PELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASN 120
PELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASN
Sbjct: 61 PELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASN 120
Query: 121 HLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQG 180
HLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQG
Sbjct: 121 HLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQG 180
Query: 181 LLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHN 240
LLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHN
Sbjct: 181 LLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHN 240
Query: 241 PLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPG 300
PLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPG
Sbjct: 241 PLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPG 300
Query: 301 QLRRLRLQGNPLWCGCQARPLLEWLARARVRSDGACQGPRRLRGEALDALRPWDLRCPGD 360
QLRRLRLQGNPLWCGCQARPLLEWLARARVRSDGACQGPRRLRGEALDALRPWDLRCPGD
Sbjct: 301 QLRRLRLQGNPLWCGCQARPLLEWLARARVRSDGACQGPRRLRGEALDALRPWDLRCPGD 360
Query: 361 AAQEEEELEERAVAGPRAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVP 420
AAQEEEELEERAVAGPRAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVP
Sbjct: 361 AAQEEEELEERAVAGPRAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVP 420
Query: 421 RGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYL 480
RGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYL
Sbjct: 421 RGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYL 480
Query: 481 SDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGD 540
SDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGD
Sbjct: 481 SDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGD 540
Query: 541 LGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQL 600
LGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQL
Sbjct: 541 LGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQL 600
Query: 601 SGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPA 660
SGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPA
Sbjct: 601 SGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPA 660
Query: 661 LPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVGATCATPPNARGQRVKAAAAVFE 720
LPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVGATCATPPNARGQRVKAAAAVFE
Sbjct: 661 LPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVGATCATPPNARGQRVKAAAAVFE 720
Query: 721 DCPGWAARKAKRTPASRPSARRTPIKGRQCGADKVGKEKGRL 762
DCPGWAARKAKRTPASRPSARRTPIKGRQCGADKVGKEKGRL
Sbjct: 721 DCPGWAARKAKRTPASRPSARRTPIKGRQCGADKVGKEKGRL 762
>gi|153251229 chondroadherin precursor [Homo sapiens]
Length = 359
Score = 255 bits (651), Expect = 1e-67
Identities = 143/343 (41%), Positives = 203/343 (59%), Gaps = 5/343 (1%)
Query: 392 AVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHL 451
A+A CP+ C C + +H C+ GLQ +P+ T+LL+L+RN+FP + +F + +L
Sbjct: 19 ALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANSFRAMPNL 77
Query: 452 VSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQ 511
VSLHLQHC I E+ AGA GL +LIYLYLS N + L A A + L YLYL+ N+ +
Sbjct: 78 VSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTE 137
Query: 512 VPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPAREL 571
+P L L +LF L L +N + L G + LRW+YLS N ++ + GAL L
Sbjct: 138 LPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENL 197
Query: 572 EKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLE 631
K H+DRNQL P+ AL L + EL+LS NPL+++ D AFQ GR L+ L+L+++ LE
Sbjct: 198 AKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLE 257
Query: 632 QICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSNPFHCDCQLLPLHRWLT 691
+ GAF G+ L+ +HL+ N+L LP+ LE + L++NP+ C CQL L RWL
Sbjct: 258 KFSDGAFLGV-TTLKHVHLENNRLNQLPSNFPFDSLETLALTNNPWKCTCQLRGLRRWLE 316
Query: 692 GLNLRVGATCATPPNARGQRVKAAAAVFEDC--PGWAARKAKR 732
R ATCA+P +GQ ++ A F C P ++KA R
Sbjct: 317 AKASRPDATCASPAKFKGQHIRDTDA-FRSCKFPTKRSKKAGR 358
Score = 183 bits (464), Expect = 6e-46
Identities = 126/345 (36%), Positives = 171/345 (49%), Gaps = 6/345 (1%)
Query: 12 LVLPLLVLLL-LAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQ 70
+V P+L+L L L A CPQ C C + +HV C L ++P + E T+ L+LQ
Sbjct: 1 MVRPMLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQ 59
Query: 71 GNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEAL 130
N V+ A +F+ +P+L L L+HC++ VA GAFRGL +L+ L L+ N +R L A
Sbjct: 60 RNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAF 119
Query: 131 DGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLS 190
D L L L L+ N + EL G L L L L +N + L A AFQG +RWL LS
Sbjct: 120 DDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLS 179
Query: 191 HNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDG 250
NALS L P AL + L + + N+L + P LS+ R + L+L HNPL +
Sbjct: 180 ENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAF 239
Query: 251 LALPG-LRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQG 309
+ L L LD L+ AF L + L N+L+ LP L L L
Sbjct: 240 QSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDSLETLALTN 299
Query: 310 NPLWCGCQARPLLEWLARARVRSDGACQGPRRLRGEAL---DALR 351
NP C CQ R L WL R D C P + +G+ + DA R
Sbjct: 300 NPWKCTCQLRGLRRWLEAKASRPDATCASPAKFKGQHIRDTDAFR 344
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 162 bits (409), Expect = 1e-39
Identities = 184/607 (30%), Positives = 240/607 (39%), Gaps = 107/607 (17%)
Query: 27 QAAAQRCPQACIC----DNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAF 82
+A CP AC+C D V C +NLT +PD +P TQ L L GN L +P AAF
Sbjct: 73 EAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAF 132
Query: 83 QGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELE 142
Q L L LNL L L +AL GL +L L LE
Sbjct: 133 QN------------------------LSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 168
Query: 143 GNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEAL 202
N L L GTF ALA+L L++N L L F+GL + L L N+L+VL A
Sbjct: 169 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF 228
Query: 203 AGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLD 262
GL +LR L L N L L P ++G L LREL L
Sbjct: 229 RGLGSLRELVLAGNRLAYL------------------QPALFSG------LAELRELDLS 264
Query: 263 GGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNPLWCGCQARP 320
AL+A+ F PRL L L N + + P G LR L L N +
Sbjct: 265 RNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHN------RVAG 318
Query: 321 LLE----WLARARVRSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVAGP 376
LLE L RV RL A+ +LRP + + LEE +
Sbjct: 319 LLEDTFPGLLGLRVL---------RLSHNAIASLRPRTFK-------DLHFLEELQL--- 359
Query: 377 RAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGF---PSDTQLLDLR 433
G R R+ + + + + LQ V G ++ +++L
Sbjct: 360 -----------GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLS 408
Query: 434 RNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAAL 493
N ++P F GLG L SLHL+ + + GL L L+L DN L G+ +L
Sbjct: 409 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSL 468
Query: 494 EGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLS 553
G L L L N+ +P + L L L L N + L LG + W+ +S
Sbjct: 469 WGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVS 528
Query: 554 GNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGN------PLRA 607
NR+ + L P L L L N LR P L L L GN PL+A
Sbjct: 529 HNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPWDCGCPLKA 584
Query: 608 LRDGAFQ 614
LRD A Q
Sbjct: 585 LRDFALQ 591
Score = 125 bits (314), Expect = 1e-28
Identities = 102/307 (33%), Positives = 139/307 (45%), Gaps = 9/307 (2%)
Query: 375 GPRAPPRGPPRGPGEERAVAPCPRACVCVPESRHSS----CEGCGLQAVPRGFPSDTQLL 430
GPR+ P PGE A CP ACVC + C L +P G P TQ L
Sbjct: 59 GPRSLEGADPGTPGEAEGPA-CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQAL 117
Query: 431 DLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSA 490
L N+ SVP AAF L L L+LQ + LE AL GL L +L+L NQL L+
Sbjct: 118 WLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLAL 177
Query: 491 AALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWV 550
P L L L NR ++ L SL+ L+L N++ L +LR +
Sbjct: 178 GTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLREL 237
Query: 551 YLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRD 610
L+GNR+ + EL +L L RN LR + LP L +L L N + A+
Sbjct: 238 VLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAP 297
Query: 611 GAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRAL--PALPSLSQLE 668
GAF + ++L+ L L+ + + + F GL GL+ L L N + +L L LE
Sbjct: 298 GAFLGL-KALRWLDLSHNRVAGLLEDTFPGL-LGLRVLRLSHNAIASLRPRTFKDLHFLE 355
Query: 669 LIDLSSN 675
+ L N
Sbjct: 356 ELQLGHN 362
Score = 109 bits (273), Expect = 8e-24
Identities = 143/503 (28%), Positives = 196/503 (38%), Gaps = 46/503 (9%)
Query: 204 GLPA-LRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLD 262
G+P + L L N L ++P L L L L + L L L L L+
Sbjct: 109 GVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 168
Query: 263 GGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNPLWCGCQARP 320
L++L FAH P L +L L N+L L +G G L L L N L
Sbjct: 169 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL-------- 220
Query: 321 LLEWLARARVRSDGACQGPRRLR-----GEALDALRPWDLRCPGDAAQEEEELEERAVAG 375
V D A +G LR G L L+P G A E +L A+
Sbjct: 221 --------AVLPDAAFRGLGSLRELVLAGNRLAYLQP--ALFSGLAELRELDLSRNALRA 270
Query: 376 PRAP-----PRGPPRGPGEERAVAPCPRACVCVPESR-----HSSCEGCGLQAVPRGFPS 425
+A PR A P A + + R H+ G + FP
Sbjct: 271 IKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGL----LEDTFPG 326
Query: 426 --DTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDN 483
++L L N S+ F L L L L H I +L + GLG+L L L N
Sbjct: 327 LLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHN 386
Query: 484 QLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGR 543
QL + A A G + + L N +P R L L SLHL+ + + R+ P
Sbjct: 387 QLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTG 446
Query: 544 TRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGN 603
LR ++L N + + +L EL +L L NQL +P +GL L L LS N
Sbjct: 447 LSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 506
Query: 604 PLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPS 663
L L A P+ R+ L ++ + LE + + LG L+ L L+ N LR P
Sbjct: 507 RLAELPADALGPLQRAF-WLDVSHNRLEALPNSLLAPLG-RLRYLSLRNNSLRTF--TPQ 562
Query: 664 LSQLELIDLSSNPFHCDCQLLPL 686
LE + L NP+ C C L L
Sbjct: 563 PPGLERLWLEGNPWDCGCPLKAL 585
Score = 105 bits (262), Expect = 2e-22
Identities = 106/291 (36%), Positives = 137/291 (47%), Gaps = 35/291 (12%)
Query: 430 LDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLS 489
L+L N +P AAF GLG L L L +A L+ +GL L L LS N L +
Sbjct: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272
Query: 490 AAALEGAPRLGYLYLERNRFLQV-PGA-----ALRAL---------------PSLFSLH- 527
A PRL LYL+RN V PGA ALR L P L L
Sbjct: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 332
Query: 528 --LQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVP 585
L NA+ L P L + L NRI +++ + +LE L LD NQL+EV
Sbjct: 333 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 392
Query: 586 TGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGL 645
GA GL + + LSGN LR L + F+ +G+ L L L S L +I P F+GL GL
Sbjct: 393 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK-LHSLHLEGSCLGRIRPHTFTGLS-GL 450
Query: 646 QSLHLQKNQLRAL--PALPSLSQLELIDLSSNPFHCDCQLLPL-HRWLTGL 693
+ L L+ N L + +L L++L +DL+SN QL L HR GL
Sbjct: 451 RRLFLKDNGLVGIEEQSLWGLAELLELDLTSN------QLTHLPHRLFQGL 495
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 162 bits (409), Expect = 1e-39
Identities = 184/607 (30%), Positives = 240/607 (39%), Gaps = 107/607 (17%)
Query: 27 QAAAQRCPQACIC----DNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAF 82
+A CP AC+C D V C +NLT +PD +P TQ L L GN L +P AAF
Sbjct: 35 EAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAF 94
Query: 83 QGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELE 142
Q L L LNL L L +AL GL +L L LE
Sbjct: 95 QN------------------------LSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 130
Query: 143 GNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEAL 202
N L L GTF ALA+L L++N L L F+GL + L L N+L+VL A
Sbjct: 131 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF 190
Query: 203 AGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLD 262
GL +LR L L N L L P ++G L LREL L
Sbjct: 191 RGLGSLRELVLAGNRLAYL------------------QPALFSG------LAELRELDLS 226
Query: 263 GGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNPLWCGCQARP 320
AL+A+ F PRL L L N + + P G LR L L N +
Sbjct: 227 RNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHN------RVAG 280
Query: 321 LLE----WLARARVRSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVAGP 376
LLE L RV RL A+ +LRP + + LEE +
Sbjct: 281 LLEDTFPGLLGLRVL---------RLSHNAIASLRPRTFK-------DLHFLEELQL--- 321
Query: 377 RAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGF---PSDTQLLDLR 433
G R R+ + + + + LQ V G ++ +++L
Sbjct: 322 -----------GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLS 370
Query: 434 RNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAAL 493
N ++P F GLG L SLHL+ + + GL L L+L DN L G+ +L
Sbjct: 371 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSL 430
Query: 494 EGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLS 553
G L L L N+ +P + L L L L N + L LG + W+ +S
Sbjct: 431 WGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVS 490
Query: 554 GNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGN------PLRA 607
NR+ + L P L L L N LR P L L L GN PL+A
Sbjct: 491 HNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPWDCGCPLKA 546
Query: 608 LRDGAFQ 614
LRD A Q
Sbjct: 547 LRDFALQ 553
Score = 125 bits (314), Expect = 1e-28
Identities = 102/307 (33%), Positives = 139/307 (45%), Gaps = 9/307 (2%)
Query: 375 GPRAPPRGPPRGPGEERAVAPCPRACVCVPESRHSS----CEGCGLQAVPRGFPSDTQLL 430
GPR+ P PGE A CP ACVC + C L +P G P TQ L
Sbjct: 21 GPRSLEGADPGTPGEAEGPA-CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQAL 79
Query: 431 DLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSA 490
L N+ SVP AAF L L L+LQ + LE AL GL L +L+L NQL L+
Sbjct: 80 WLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLAL 139
Query: 491 AALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWV 550
P L L L NR ++ L SL+ L+L N++ L +LR +
Sbjct: 140 GTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLREL 199
Query: 551 YLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRD 610
L+GNR+ + EL +L L RN LR + LP L +L L N + A+
Sbjct: 200 VLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAP 259
Query: 611 GAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRAL--PALPSLSQLE 668
GAF + ++L+ L L+ + + + F GL GL+ L L N + +L L LE
Sbjct: 260 GAFLGL-KALRWLDLSHNRVAGLLEDTFPGL-LGLRVLRLSHNAIASLRPRTFKDLHFLE 317
Query: 669 LIDLSSN 675
+ L N
Sbjct: 318 ELQLGHN 324
Score = 109 bits (273), Expect = 8e-24
Identities = 143/503 (28%), Positives = 196/503 (38%), Gaps = 46/503 (9%)
Query: 204 GLPA-LRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLD 262
G+P + L L N L ++P L L L L + L L L L L+
Sbjct: 71 GVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 130
Query: 263 GGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNPLWCGCQARP 320
L++L FAH P L +L L N+L L +G G L L L N L
Sbjct: 131 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL-------- 182
Query: 321 LLEWLARARVRSDGACQGPRRLR-----GEALDALRPWDLRCPGDAAQEEEELEERAVAG 375
V D A +G LR G L L+P G A E +L A+
Sbjct: 183 --------AVLPDAAFRGLGSLRELVLAGNRLAYLQP--ALFSGLAELRELDLSRNALRA 232
Query: 376 PRAP-----PRGPPRGPGEERAVAPCPRACVCVPESR-----HSSCEGCGLQAVPRGFPS 425
+A PR A P A + + R H+ G + FP
Sbjct: 233 IKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGL----LEDTFPG 288
Query: 426 --DTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDN 483
++L L N S+ F L L L L H I +L + GLG+L L L N
Sbjct: 289 LLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHN 348
Query: 484 QLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGR 543
QL + A A G + + L N +P R L L SLHL+ + + R+ P
Sbjct: 349 QLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTG 408
Query: 544 TRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGN 603
LR ++L N + + +L EL +L L NQL +P +GL L L LS N
Sbjct: 409 LSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 468
Query: 604 PLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPS 663
L L A P+ R+ L ++ + LE + + LG L+ L L+ N LR P
Sbjct: 469 RLAELPADALGPLQRAF-WLDVSHNRLEALPNSLLAPLG-RLRYLSLRNNSLRTF--TPQ 524
Query: 664 LSQLELIDLSSNPFHCDCQLLPL 686
LE + L NP+ C C L L
Sbjct: 525 PPGLERLWLEGNPWDCGCPLKAL 547
Score = 105 bits (262), Expect = 2e-22
Identities = 106/291 (36%), Positives = 137/291 (47%), Gaps = 35/291 (12%)
Query: 430 LDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLS 489
L+L N +P AAF GLG L L L +A L+ +GL L L LS N L +
Sbjct: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
Query: 490 AAALEGAPRLGYLYLERNRFLQV-PGA-----ALRAL---------------PSLFSLH- 527
A PRL LYL+RN V PGA ALR L P L L
Sbjct: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294
Query: 528 --LQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVP 585
L NA+ L P L + L NRI +++ + +LE L LD NQL+EV
Sbjct: 295 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 354
Query: 586 TGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGL 645
GA GL + + LSGN LR L + F+ +G+ L L L S L +I P F+GL GL
Sbjct: 355 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK-LHSLHLEGSCLGRIRPHTFTGLS-GL 412
Query: 646 QSLHLQKNQLRAL--PALPSLSQLELIDLSSNPFHCDCQLLPL-HRWLTGL 693
+ L L+ N L + +L L++L +DL+SN QL L HR GL
Sbjct: 413 RRLFLKDNGLVGIEEQSLWGLAELLELDLTSN------QLTHLPHRLFQGL 457
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 147 bits (371), Expect = 4e-35
Identities = 125/405 (30%), Positives = 166/405 (40%), Gaps = 71/405 (17%)
Query: 15 PLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLL 74
P L+ LLL P + CP C C + + V C ++ L VP +P T+ LDL GN L
Sbjct: 15 PPLLFLLLLPGGSGGS--CPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRL 72
Query: 75 KVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLG 134
+ + L LDL + ++ + GAF GL LL L L N LR + GL
Sbjct: 73 WGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLS 132
Query: 135 SLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNAL 194
+L L+L N + G FG LG+L L + N LV++ AF GL ++ L L L
Sbjct: 133 ALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNL 192
Query: 195 SVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLAR-------------------- 234
S + ALA LPAL L L ++ LP L RGL +
Sbjct: 193 STVPGLALARLPALVALRLRELDIGRLPAGAL---RGLGQLKELEIHLWPSLEALDPGSL 249
Query: 235 -------------------------------LELGHNPLTYAGEEDGLALPGLRELLLDG 263
L+L NP++ L L+EL L G
Sbjct: 250 VGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSG 309
Query: 264 GALQALGPRAFAHCPRLHTLDLRGNQLDTL--PPLQGPGQLRRLRLQGNPLWCGCQARPL 321
L ++ AF H LD+ N L TL P +L LRL GNPL C C+
Sbjct: 310 ACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCR---- 365
Query: 322 LEWLARARVRSD-----GACQGPRRLRGEAL----DALRPWDLRC 357
L WL R R D AC GP ++G++L D L P C
Sbjct: 366 LLWLLRLRRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGHFTC 410
Score = 117 bits (293), Expect = 4e-26
Identities = 117/373 (31%), Positives = 155/373 (41%), Gaps = 61/373 (16%)
Query: 396 CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLH 455
CP C C + + C L+AVP G P DT+LLDL N + + L L L
Sbjct: 31 CPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELD 90
Query: 456 LQHCGIAELEAGALAGLGRLIYLYLSDNQL--------AGLSA----------------- 490
L + ++ LE GA GL L+ L L N+L +GLSA
Sbjct: 91 LSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDG 150
Query: 491 -----------------------AALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLH 527
A G +L L LER VPG AL LP+L +L
Sbjct: 151 AFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALR 210
Query: 528 LQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPAR----ELEKLHLDRNQLRE 583
L++ + RL G L L+ + + SL AL P L L + R L
Sbjct: 211 LRELDIGRLPAGALRGLGQLKELEIH----LWPSLEALDPGSLVGLNLSSLAITRCNLSS 266
Query: 584 VPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGP 643
VP AL L L L LS NP+ A+ P+ R LQ L L+ + L I AF GL
Sbjct: 267 VPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVR-LQELRLSGACLTSIAAHAFHGL-T 324
Query: 644 GLQSLHLQKNQLRALP--ALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVG-AT 700
L + N L+ L A PS +L + LS NP CDC+LL L R L+ +
Sbjct: 325 AFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPA 384
Query: 701 CATPPNARGQRVK 713
CA P + +G+ +K
Sbjct: 385 CAGPHHVQGKSLK 397
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 145 bits (367), Expect = 1e-34
Identities = 122/383 (31%), Positives = 161/383 (42%), Gaps = 59/383 (15%)
Query: 20 LLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPA 79
LLL PA A CP C C R VAC + LT VPD IP T+ L+L N ++ +
Sbjct: 12 LLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNP 71
Query: 80 AAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRL 139
+P L LDL + V GAF L RL +L L N L+ +P L +L L
Sbjct: 72 GDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLL 131
Query: 140 ELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAP 199
+L N L L TF L +L L + N LV++ AF GLL + L L L+ L+
Sbjct: 132 DLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSG 191
Query: 200 EALAGLPAL------------------RR------------------------------L 211
E+L L +L RR L
Sbjct: 192 ESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSL 251
Query: 212 SLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGP 271
S+ H + A+P L L L L HNP++ L LREL L G L + P
Sbjct: 252 SVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEP 311
Query: 272 RAFAHCPRLHTLDLRGNQLDTL--PPLQGPGQLRRLRLQGNPLWCGCQARPLLEWLARAR 329
+AF ++ L+L N L TL L LR+ GNPL C C+ L W+ + R
Sbjct: 312 QAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCR----LLWIVQRR 367
Query: 330 --VRSDG---ACQGPRRLRGEAL 347
+ DG AC P +RG+AL
Sbjct: 368 KTLNFDGRLPACATPAEVRGDAL 390
Score = 106 bits (264), Expect = 9e-23
Identities = 115/386 (29%), Positives = 160/386 (41%), Gaps = 62/386 (16%)
Query: 380 PRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPS 439
P PP G CP C C ++R +C L AVP G P++T+LL+L RN
Sbjct: 16 PAAPPPAGG-------CPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRC 68
Query: 440 VPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRL 499
+ L L L L IA +E GA A L RL L L NQL + L
Sbjct: 69 LNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNL 128
Query: 500 GYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITE 559
L L N+ + + + L SL L + DN + ++ AL + L +T
Sbjct: 129 TLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTA 188
Query: 560 VSLGALGPARELEKLHL---------DRN----------------QLREVPTGALEGL-- 592
+S +LG R L L L D+N L EV G+L GL
Sbjct: 189 LSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNL 248
Query: 593 -------------PA--------LLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLE 631
PA L L LS NP+ + G+F+ + R L+ L L + L
Sbjct: 249 TSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVR-LRELHLAGALLA 307
Query: 632 QICPGAFSGLGPGLQSLHLQKNQLRAL--PALPSLSQLELIDLSSNPFHCDCQLLPLHRW 689
+ P AF GL ++ L+L N L L S++ LE + + NP CDC+LL + +
Sbjct: 308 VVEPQAFLGLRQ-IRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQR 366
Query: 690 LTGLNL--RVGATCATPPNARGQRVK 713
LN R+ A CATP RG ++
Sbjct: 367 RKTLNFDGRLPA-CATPAEVRGDALR 391
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 142 bits (357), Expect = 2e-33
Identities = 105/299 (35%), Positives = 135/299 (45%), Gaps = 5/299 (1%)
Query: 65 QRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRE 124
+ L LQGN L+ +P FQ + HL L+L + + E F L L L L++N L
Sbjct: 148 ESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSG 207
Query: 125 LPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRV 184
LPQ LGSL+ L L+ N + EL P F L L L L NA+ +LP F L +
Sbjct: 208 LPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNL 267
Query: 185 RWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTY 244
+L L N L VL A P L LSL HN+L+ + + L L L +N +T+
Sbjct: 268 TFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITH 327
Query: 245 AGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQL 302
L L +L L L AL P F + +L L L NQL TLP L
Sbjct: 328 LPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNL 387
Query: 303 RRLRLQGNPLWCGCQARPLLEWLARARVR---SDGACQGPRRLRGEALDALRPWDLRCP 358
L L GNP C C L WL + R C GP L+G+ + AL L CP
Sbjct: 388 FNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVCP 446
Score = 111 bits (277), Expect = 3e-24
Identities = 100/299 (33%), Positives = 128/299 (42%), Gaps = 30/299 (10%)
Query: 19 LLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIP 78
LLLLA AQ CP C C + V C + L VP IP T+ + +
Sbjct: 12 LLLLA----RPAQPCPMGCDC--FVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLE 65
Query: 79 AAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRL----------------LLLNLAS--- 119
AF P+LT + + ++ AF GL RL + NL S
Sbjct: 66 TRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGK 125
Query: 120 -----NHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLP 174
N L LP+ L +L L L+GN L+ L F L L TLNLA N L LP
Sbjct: 126 LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185
Query: 175 AMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLAR 234
F L ++ L+LS+NALS L L +L+ L L N + LP V SQ L R
Sbjct: 186 EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245
Query: 235 LELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTL 293
L L N +T+ +L L L L L+ L FAH P L L L NQL+T+
Sbjct: 246 LWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETV 304
Score = 102 bits (255), Expect = 1e-21
Identities = 97/322 (30%), Positives = 122/322 (37%), Gaps = 29/322 (9%)
Query: 430 LDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLS 489
L L N ++P F L L SLHLQ + L L L L L+ N LA L
Sbjct: 126 LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185
Query: 490 AAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRW 549
L L L N +P L SL L L N + L P + L
Sbjct: 186 EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245
Query: 550 VYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALR 609
++L N IT + L L L L N LR +P G P L+ L L+ N L +
Sbjct: 246 LWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVA 305
Query: 610 DGAFQ------------------PVG-----RSLQHLFLNSSGLEQICPGAFSGLGPGLQ 646
+G F P G L L+L S+ L + P F L L+
Sbjct: 306 EGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSK-LE 364
Query: 647 SLHLQKNQLRALPALPSLSQLELIDLS--SNPFHCDCQLLPLHRWL---TGLNLRVGATC 701
L L KNQL LP + L +L+ NP+ CDC L L WL T L + C
Sbjct: 365 LLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYC 424
Query: 702 ATPPNARGQRVKAAAAVFEDCP 723
A P +GQ V A CP
Sbjct: 425 AGPAYLKGQVVPALNEKQLVCP 446
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 136 bits (343), Expect = 6e-32
Identities = 106/373 (28%), Positives = 161/373 (43%), Gaps = 52/373 (13%)
Query: 391 RAVAPCPRAC-VCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLG 449
+ + C C +C R +C GL ++P+ FP T L L N+ + + GL
Sbjct: 27 KEILGCSSVCQLCT--GRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLH 84
Query: 450 HLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRF 509
LV+L+L + I + A L L +L+L++N + L +G L LYL+ N+
Sbjct: 85 SLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQV 144
Query: 510 LQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPAR 569
VP L S+ L+LQ N + L G ALR + LS N I +S
Sbjct: 145 SFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLE 204
Query: 570 ELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVG------------ 617
L L+L N L +VP+ A E L +L L LS NP+ A++ AF+ +
Sbjct: 205 NLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRI 264
Query: 618 -----------RSLQHLFLNSSGLEQICPGAFS------------------------GLG 642
+L+HL L+ + LE + FS +G
Sbjct: 265 RNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMG 324
Query: 643 PGLQSLHLQKNQLRAL--PALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVGAT 700
L+ L+L N L AL L LS L + +SNP+ C+C+LL L WL + +
Sbjct: 325 ASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITLNIY 384
Query: 701 CATPPNARGQRVK 713
C PP+ RG+ ++
Sbjct: 385 CQNPPSMRGRALR 397
Score = 115 bits (288), Expect = 2e-25
Identities = 89/284 (31%), Positives = 129/284 (45%), Gaps = 3/284 (1%)
Query: 67 LDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELP 126
L L N +K + F+G+ +L +L L++ +V V G F L + LNL N L L
Sbjct: 113 LFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLG 172
Query: 127 QEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRW 186
G+ +LR L+L N + + F L LA L L N L +P+ AF+ L +R
Sbjct: 173 SGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRR 232
Query: 187 LRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAG 246
L LSHN + + P A GL L L L ++ ++ + S L L L HN L
Sbjct: 233 LSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLN 292
Query: 247 EEDGLALPGLRELLLDGGALQALGPRAFAHC-PRLHTLDLRGNQLDTLPP--LQGPGQLR 303
+ L L L LD + ++ F + L L+L N L L P L+ L
Sbjct: 293 SDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLI 352
Query: 304 RLRLQGNPLWCGCQARPLLEWLARARVRSDGACQGPRRLRGEAL 347
L+ NP C C+ L +WLA + + + CQ P +RG AL
Sbjct: 353 HLQANSNPWECNCKLLGLRDWLASSAITLNIYCQNPPSMRGRAL 396
>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
Length = 420
Score = 136 bits (343), Expect = 6e-32
Identities = 129/396 (32%), Positives = 162/396 (40%), Gaps = 66/396 (16%)
Query: 1 MEGPRSSTHVPLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAI 60
+ G R P LL++LL P AA CP C C +S V+C+ N + VP ++
Sbjct: 2 LPGLRRLLQAPASACLLLMLLALPL---AAPSCPMLCTCYSSPPTVSCQANNFSSVPLSL 58
Query: 61 PELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASN 120
P TQRL LQ NL++ + F LL L L SN
Sbjct: 59 PPSTQRLFLQNNLIRTLRPGTFGS--------------------------NLLTLWLFSN 92
Query: 121 HLRELPQEALDGLGSLRRLELEGNA-LEELRPGTFGALGALATLNLAHNALVYLPAMAFQ 179
+L + L +L L+L N L L P TF L L +L+L L LP F+
Sbjct: 93 NLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFR 152
Query: 180 GLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGH 239
GL+ +++L L N+L L + A L L L LH N L+ L V RGL L+
Sbjct: 153 GLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVF---RGLGSLD--- 206
Query: 240 NPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP--PLQ 297
LLL G LQ + AF RL L L N L +LP L
Sbjct: 207 ------------------RLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALA 248
Query: 298 GPGQLRRLRLQGNPLWCGCQARPLLEWLARARV-RSDGACQGPRRLRGEALDALRPWDLR 356
L LRL NP C C+ARPL W RARV SD C P +G L ALR D +
Sbjct: 249 DLPSLEFLRLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLRALREADFQ 308
Query: 357 C--------PGDAAQEEEELEE-RAVAGPRAPPRGP 383
PG A+ VA APP P
Sbjct: 309 ACPPAAPTRPGSRARGNSSSNHLYGVAEAGAPPADP 344
Score = 96.7 bits (239), Expect = 7e-20
Identities = 95/337 (28%), Positives = 133/337 (39%), Gaps = 57/337 (16%)
Query: 392 AVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHL 451
A CP C C SC+ +VP P TQ L L+ N ++ F
Sbjct: 27 AAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGS---- 82
Query: 452 VSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQ 511
L+ L+L N L+ + L L L NR L+
Sbjct: 83 ----------------------NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLR 120
Query: 512 -VPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARE 570
+ + L L SLHL + L PG++ R
Sbjct: 121 SLEPDTFQGLERLQSLHLYRCQLSSL-PGNIFRGLV-----------------------S 156
Query: 571 LEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGL 630
L+ L+L N L + L L L L GN LR L + F+ +G SL L L+ + L
Sbjct: 157 LQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLG-SLDRLLLHGNRL 215
Query: 631 EQICPGAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQLELIDLSSNPFHCDCQLLPLHR 688
+ + AF GL L L+L N L +LP AL L LE + L++NP+ CDC+ PL
Sbjct: 216 QGVHRAAFRGLSR-LTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDCRARPLWA 274
Query: 689 WLTGLNLRVG-ATCATPPNARGQRVKA-AAAVFEDCP 723
W + TCATPP +G+ ++A A F+ CP
Sbjct: 275 WFQRARVSSSDVTCATPPERQGRDLRALREADFQACP 311
>gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo
sapiens]
Length = 522
Score = 135 bits (339), Expect = 2e-31
Identities = 124/405 (30%), Positives = 174/405 (42%), Gaps = 17/405 (4%)
Query: 17 LVLLLLAPARQ---AAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNL 73
+VL LL Q AA CPQ C C+ R + C NLTE P + L L L+ N
Sbjct: 20 VVLCLLGACFQMLPAAPSGCPQLCRCEG--RLLYCEALNLTEAPHNLSGLLG-LSLRYNS 76
Query: 74 LKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGL 133
L + A F G+ LT L L H + V AF+ L R+ L L+SN + +LP +
Sbjct: 77 LSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPM 136
Query: 134 GSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNA 193
+LR ++L N L+ L P F L L TL++ NA+ ++P FQ +++L + +N
Sbjct: 137 PNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQ 196
Query: 194 LSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLAL 253
L LA + AGL L L L HN+L + + L L L N +
Sbjct: 197 LKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVW 256
Query: 254 PGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNP 311
L ++ L G ++ + P F P L +L L N+L + P L L + L GN
Sbjct: 257 -NLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
Query: 312 LWCGCQARPLLEWLARARVRSDG--ACQGPRRLRGE-ALDALRPWDLRCPGDAAQEEEEL 368
CG L WL + R DG C P +GE LDA+ + L C A L
Sbjct: 316 WDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHL-CEDGAEPTSGHL 374
Query: 369 ----EERAVAGPRAPPRGPPRGPGEERAVAPCPRACVCVPESRHS 409
R+ GP A GE + A V +P H+
Sbjct: 375 LSAVTNRSDLGPPASSATTLADGGEGQHDGTFEPATVALPGGEHA 419
Score = 101 bits (252), Expect = 2e-21
Identities = 95/357 (26%), Positives = 141/357 (39%), Gaps = 54/357 (15%)
Query: 392 AVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHL 451
A + CP+ C C E R CE L P L L
Sbjct: 35 APSGCPQLCRC--EGRLLYCEALNLTEAPHN-------------------------LSGL 67
Query: 452 VSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQ 511
+ L L++ ++EL AG GL +L +LYL N + + A + R+ L L N+ Q
Sbjct: 68 LGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQ 127
Query: 512 VPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPAREL 571
+P R +P+L S+ L N + LAP R L +++ N I V + R L
Sbjct: 128 LPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSL 187
Query: 572 EKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGR------------- 618
+ L + NQL+ + + GL L EL L N L + F +
Sbjct: 188 KFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAI 247
Query: 619 ---------SLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQL 667
+L+ + L+ + +E + P F + P LQSL L N+L + L S L
Sbjct: 248 VVSSLDWVWNLEKMDLSGNEIEYMEPHVFETV-PHLQSLQLDSNRLTYIEPRILNSWKSL 306
Query: 668 ELIDLSSNPFHCDCQLLPLHRWLTGLNLRVGAT--CATPPNARGQRVKAAAAVFEDC 722
I L+ N + C + L WL R CA+P A+G+ V A F C
Sbjct: 307 TSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLC 363
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 134 bits (336), Expect = 4e-31
Identities = 192/799 (24%), Positives = 294/799 (36%), Gaps = 159/799 (19%)
Query: 66 RLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLN--------- 116
RLDL N ++ IP AF+G L +L L ++ + EGAFR L L +L
Sbjct: 137 RLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTI 196
Query: 117 ---------------LASNHL-------------RELPQEAL----DGLGSLRRLELEGN 144
L SNHL R+ P L G SLR L +
Sbjct: 197 PVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEV 256
Query: 145 ALEELRPGTFGALGALATLNLAHNALVYLPAMAF--QGLLRVRW---------------- 186
E G G + T L+ + PAM G++ R
Sbjct: 257 QKSEFSCSGQGEAGRVPTCTLSSGSC---PAMCTCSNGIVDCRGKGLTAIPANLPETMTE 313
Query: 187 LRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAG 246
+RL N + + P A + LRR+ L +N++ + R L L L N +T
Sbjct: 314 IRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLP 373
Query: 247 EEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRR 304
L L+ LLL+ + + P AF L L L N++ +L ++
Sbjct: 374 RGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQT 433
Query: 305 LRLQGNPLWCGCQARPLLEWLARARVRSDGA-CQGPRRLRGEALDALRPWDLRCPGDAAQ 363
L L NP C C + L ++L + + GA C PRRL + + ++ RC +A+
Sbjct: 434 LHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRC---SAK 490
Query: 364 EEEELEERAVAGPRAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGF 423
E+ + P + E + CP C C E+ C L +P
Sbjct: 491 EQYFI----------PGTEDYQLNSECNSDVVCPHKCRC--EANVVECSSLKLTKIPERI 538
Query: 424 PSDTQLLDLRRNHFPSVPRAA-FPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSD 482
P T L L N + F L HL ++L + ++E+E GA G + L+L+
Sbjct: 539 PQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTA 598
Query: 483 NQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLG 542
NQL + + G L L L NR + + L ++ L L DN + ++PG
Sbjct: 599 NQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFD 658
Query: 543 RTRALRWVYLSGNRIT-EVSLGALGPARELEKLHLDRNQ------LREVP---------- 585
++L + L N L LG K+ + LR++P
Sbjct: 659 TLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFR 718
Query: 586 --TGALEG--LP--------ALLE--LQLSGNPLRALRDGAFQPVG-------------- 617
G EG LP A L+ ++ S LRAL G + V
Sbjct: 719 CEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPG 778
Query: 618 -----RSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQLELI 670
+ LQ + L+++ + + +F+ + L +L L N L+ +P A L L L+
Sbjct: 779 QLSTFKYLQLVDLSNNKISSLSNSSFTNMSQ-LTTLILSYNALQCIPPLAFQGLRSLRLL 837
Query: 671 DL------------------------SSNPFHCDCQLLPLHRWL-TGLNLRVGATCATPP 705
L +NP +CDC L L W+ TG A CA P
Sbjct: 838 SLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQ 897
Query: 706 NARGQRVKAAAAVFEDCPG 724
+ G+ + A +C G
Sbjct: 898 DMEGKLLLTTPAKKFECQG 916
Score = 133 bits (334), Expect = 7e-31
Identities = 117/419 (27%), Positives = 163/419 (38%), Gaps = 45/419 (10%)
Query: 138 RLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVL 197
RLEL GN + + F L L L L N + + AF + + LRL+ N L +L
Sbjct: 65 RLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHML 124
Query: 198 APEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLR 257
AL RL L N +QA+P A L L+L N ++ E AL GL
Sbjct: 125 PELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLE 184
Query: 258 ELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLWCGCQ 317
L L+ + + +F H P+L T RL N L+C C
Sbjct: 185 VLTLNNNNITTIPVSSFNHMPKLRT----------------------FRLHSNHLFCDCH 222
Query: 318 ARPLLEWL-ARARVRSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVAGP 376
L +WL R + C GP LRG + ++ + C G + AG
Sbjct: 223 LAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSG-----------QGEAG- 270
Query: 377 RAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNH 436
R P + CP C C + C G GL A+P P + L N
Sbjct: 271 --------RVPTCTLSSGSCPAMCTC--SNGIVDCRGKGLTAIPANLPETMTEIRLELNG 320
Query: 437 FPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGA 496
S+P AF L + L + IAE+ A GL L L L N++ L G
Sbjct: 321 IKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGL 380
Query: 497 PRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGN 555
L L L N+ + A + L +L L L DN + LA G RA++ ++L+ N
Sbjct: 381 YTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN 439
Score = 95.5 bits (236), Expect = 2e-19
Identities = 92/360 (25%), Positives = 140/360 (38%), Gaps = 64/360 (17%)
Query: 13 VLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGN 72
V P L LLL A A + A CP C C + V C L +P IP T+RL+L GN
Sbjct: 14 VRPELWLLLWAAAWRLGASACPALCTCTGTT--VDCHGTGLQAIPKNIPRNTERLELNGN 71
Query: 73 LLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDG 132
+ I F G+ L L L ++ V GAF + L L L N L LP+
Sbjct: 72 NITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQN 131
Query: 133 LGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHN 192
+L RL+L NA++ + F L L L N + + AF+ L + L L++N
Sbjct: 132 NQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNN 191
Query: 193 ALSVLAPEALAGLPALRRLSLHHNEL----------------------QALPGPVLSQAR 230
++ + + +P LR LH N L GP + R
Sbjct: 192 NITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGP--ASLR 249
Query: 231 GLARLELGHNPLTYAGEEDGLALP------------------------------------ 254
GL E+ + + +G+ + +P
Sbjct: 250 GLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPE 309
Query: 255 GLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNPL 312
+ E+ L+ ++++ P AF+ +L +DL NQ+ + P QG L L L GN +
Sbjct: 310 TMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKI 369
Score = 86.3 bits (212), Expect = 1e-16
Identities = 73/239 (30%), Positives = 107/239 (44%), Gaps = 12/239 (5%)
Query: 514 GAALRALPSLFS-----LHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPA 568
G L+A+P L L N + R+ D + LR + L N+I V GA
Sbjct: 49 GTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDM 108
Query: 569 RELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSS 628
+ELE+L L+RNQL +P + AL L LS N ++A+ AF+ L++L L+ +
Sbjct: 109 KELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRG-ATDLKNLQLDKN 167
Query: 629 GLEQICPGAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQLELIDLSSNPFHCDCQLLPL 686
+ I GAF L GL+ L L N + +P + + +L L SN CDC L L
Sbjct: 168 QISCIEEGAFRAL-RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWL 226
Query: 687 HRWLTGL-NLRVGATCATPPNARGQRVKAAAAVFEDCPGWAARKAKRTPASRPSARRTP 744
+WL + + C+ P + RG V C G +A R P S+ P
Sbjct: 227 SQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQG--EAGRVPTCTLSSGSCP 283
Score = 84.7 bits (208), Expect = 3e-16
Identities = 55/169 (32%), Positives = 82/169 (48%), Gaps = 2/169 (1%)
Query: 24 PARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQ 83
P ++ CP C C N V CR + LT +P +PE + L+ N +K IP AF
Sbjct: 273 PTCTLSSGSCPAMCTCSNGI--VDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFS 330
Query: 84 GVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEG 143
L +DL + ++ +A AF+GL L L L N + +LP+ GL +L+ L L
Sbjct: 331 PYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNA 390
Query: 144 NALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHN 192
N + +RP F L L+ L+L N + L F L ++ L L+ N
Sbjct: 391 NKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN 439
Score = 82.8 bits (203), Expect = 1e-15
Identities = 103/430 (23%), Positives = 148/430 (34%), Gaps = 129/430 (30%)
Query: 33 CPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQGVPHLTHLD 92
CP C C+ + V C LT++P+ IP+ T L L N + ++ A
Sbjct: 513 CPHKCRCEANV--VECSSLKLTKIPERIPQSTAELRLNNNEISILEAT------------ 558
Query: 93 LRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPG 152
G F+ L L +NL++N + E+ A +G S+ L L N LE +R G
Sbjct: 559 -----------GMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSG 607
Query: 153 TFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLS 212
F L L TL L +N + + +F GL VR L L N ++ ++P A L +L L+
Sbjct: 608 MFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLN 667
Query: 213 LHHNELQ-----ALPGPVLSQARGLARLELGHNP----------------LTYAGEEDGL 251
L N A G L + + + NP G+E+G
Sbjct: 668 LLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGG 727
Query: 252 ALP-------------------------------GLRELLLDGGALQALGPRAFAHCPRL 280
LP + EL LDG L P + L
Sbjct: 728 CLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQF-TLVPGQLSTFKYL 786
Query: 281 HTLDLRGNQLDTL------------------------PPL--QGPGQLRRLRLQG----- 309
+DL N++ +L PPL QG LR L L G
Sbjct: 787 QLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIST 846
Query: 310 -------------------NPLWCGCQARPLLEWLARA-RVRSDGACQGPRRLRGEALDA 349
NPL+C C R L W+ + C GP+ + G+ L
Sbjct: 847 LQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLT 906
Query: 350 LRPWDLRCPG 359
C G
Sbjct: 907 TPAKKFECQG 916
Score = 82.4 bits (202), Expect = 1e-15
Identities = 55/186 (29%), Positives = 78/186 (41%), Gaps = 2/186 (1%)
Query: 396 CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLH 455
CP C C + C G GLQA+P+ P +T+ L+L N+ + + F GL L L
Sbjct: 34 CPALCTCTGTT--VDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQ 91
Query: 456 LQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGA 515
L I +E GA + L L L+ NQL L + L L L N +P
Sbjct: 92 LMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRK 151
Query: 516 ALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLH 575
A R L +L L N + + G R L + L+ N IT + + + +L
Sbjct: 152 AFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFR 211
Query: 576 LDRNQL 581
L N L
Sbjct: 212 LHSNHL 217
Score = 67.8 bits (164), Expect = 4e-11
Identities = 43/139 (30%), Positives = 71/139 (51%), Gaps = 3/139 (2%)
Query: 32 RCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQGVPHLTHL 91
+CPQ C C ++ V C ++L +P IP+ L L GN ++P +L +
Sbjct: 733 QCPQECACLDTV--VRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQ-LSTFKYLQLV 789
Query: 92 DLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRP 151
DL + ++ ++ +F + +L L L+ N L+ +P A GL SLR L L GN + L+
Sbjct: 790 DLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQE 849
Query: 152 GTFGALGALATLNLAHNAL 170
G F + +L+ L + N L
Sbjct: 850 GIFADVTSLSHLAIGANPL 868
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 132 bits (332), Expect = 1e-30
Identities = 114/419 (27%), Positives = 166/419 (39%), Gaps = 48/419 (11%)
Query: 138 RLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVL 197
RL+L GN + + F L L L L N + + AFQ L + LRL+ N L +
Sbjct: 59 RLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLF 118
Query: 198 APEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLR 257
G L RL L N++QA+P A + L+L +N ++ + AL L
Sbjct: 119 PELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLE 178
Query: 258 ELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLWCGCQ 317
L L+ + L +F H P+L T RL N L+C C
Sbjct: 179 VLTLNNNNITRLSVASFNHMPKLRTF----------------------RLHSNNLYCDCH 216
Query: 318 ARPLLEWLA-RARVRSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVAGP 376
L +WL R RV C GP LRG + ++ + C G ++ P
Sbjct: 217 LAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSG----------HQSFMAP 266
Query: 377 RAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNH 436
+V CP AC C + C G GL +P P + L +N
Sbjct: 267 SC-------------SVLHCPAACTC--SNNIVDCRGKGLTEIPTNLPETITEIRLEQNT 311
Query: 437 FPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGA 496
+P AF L + L + I+EL A GL L L L N++ L + EG
Sbjct: 312 IKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGL 371
Query: 497 PRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGN 555
L L L N+ + A + L +L L L DN + +A G RA++ ++L+ N
Sbjct: 372 FSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQN 430
Score = 103 bits (258), Expect = 5e-22
Identities = 155/631 (24%), Positives = 230/631 (36%), Gaps = 129/631 (20%)
Query: 160 LATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQ 219
+ + L N + +P AF ++R + LS+N +S LAP+A GL +L L L+ N++
Sbjct: 302 ITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKIT 361
Query: 220 ALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPR 279
LP + GL L+L LLL+ + L AF
Sbjct: 362 ELPKSLFE---GLFSLQL---------------------LLLNANKINCLRVDAFQDLHN 397
Query: 280 LHTLDLRGNQLDTLP-----PLQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRSDG 334
L+ L L N+L T+ PL+ ++ + L NP C C + L ++L + + G
Sbjct: 398 LNLLSLYDNKLQTIAKGTFSPLRA---IQTMHLAQNPFICDCHLKWLADYLHTNPIETSG 454
Query: 335 A-CQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVAGPRAPPRGPPRGPGEERAV 393
A C PRRL + + ++ RC E+ + G + G+ A
Sbjct: 455 ARCTSPRRLANKRIGQIKSKKFRCSAK--------EQYFIPGTEDYRS---KLSGDCFAD 503
Query: 394 APCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFP--------------- 438
CP C C E C L +P P T L L N F
Sbjct: 504 LACPEKCRC--EGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLR 561
Query: 439 ----------------------------------SVPRAAFPGLGHLVSLHLQHCGIAEL 464
+V F GL L +L L+ I +
Sbjct: 562 KINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCV 621
Query: 465 EAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRF-----LQVPGAALRA 519
+ GL + L L DNQ+ ++ A + L L L N F L G LR
Sbjct: 622 GNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRK 681
Query: 520 LPS------------LFSLHLQDNAVDRLAPGD---------LGRTRALRWVYLSGNRIT 558
L + +QD A+ D L R + R +
Sbjct: 682 KRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRCS 741
Query: 559 EVSLGAL--GPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPV 616
L L G R++ +L+LD NQ VP L L + LS N + L + +F +
Sbjct: 742 NKGLKVLPKGIPRDVTELYLDGNQFTLVPK-ELSNYKHLTLIDLSNNRISTLSNQSFSNM 800
Query: 617 GRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQLELIDLSS 674
+ L L L+ + L I P F GL L+ L L N + +P A LS L + + +
Sbjct: 801 TQLLT-LILSYNRLRCIPPRTFDGL-KSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGA 858
Query: 675 NPFHCDCQLLPLHRWLTGLNLRVG-ATCATP 704
NP +CDC + L W+ G A CA P
Sbjct: 859 NPLYCDCNMQWLSDWVKSEYKEPGIARCAGP 889
Score = 102 bits (253), Expect = 2e-21
Identities = 98/356 (27%), Positives = 144/356 (40%), Gaps = 59/356 (16%)
Query: 13 VLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGN 72
+L L + L+LA + A Q CP C C S V C L VP IP T+RLDL GN
Sbjct: 8 MLSLSLGLVLAILNKVAPQACPAQCSCSGST--VDCHGLALRSVPRNIPRNTERLDLNGN 65
Query: 73 LLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDG 132
+ I F G+ HL L L ++ + GAF+ L L L L NHL+ P+ G
Sbjct: 66 NITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLG 125
Query: 133 LGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHN 192
L RL+L N ++ + F + L L +N + + AF+ L + L L++N
Sbjct: 126 TAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNN 185
Query: 193 ALSVLAPEALAGLPALRRLSLHHNEL--------------QALPGPVLSQARGLARLELG 238
++ L+ + +P LR LH N L Q + +Q G + L G
Sbjct: 186 NITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLR-G 244
Query: 239 HN-------PLTYAGEEDGLAL----------------------PGLRE----------- 258
HN +G + +A GL E
Sbjct: 245 HNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITE 304
Query: 259 LLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNPL 312
+ L+ ++ + P AF+ +L +DL NQ+ L P QG L L L GN +
Sbjct: 305 IRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI 360
Score = 92.8 bits (229), Expect = 1e-18
Identities = 59/168 (35%), Positives = 84/168 (50%), Gaps = 2/168 (1%)
Query: 25 ARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQG 84
A + CP AC C N+ V CR + LTE+P +PE + L+ N +KVIP AF
Sbjct: 265 APSCSVLHCPAACTCSNNI--VDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSP 322
Query: 85 VPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGN 144
L +DL + ++ +A AF+GL L L L N + ELP+ +GL SL+ L L N
Sbjct: 323 YKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNAN 382
Query: 145 ALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHN 192
+ LR F L L L+L N L + F L ++ + L+ N
Sbjct: 383 KINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQN 430
Score = 83.6 bits (205), Expect = 6e-16
Identities = 59/191 (30%), Positives = 83/191 (43%), Gaps = 4/191 (2%)
Query: 393 VAP--CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGH 450
VAP CP C C + C G L++VPR P +T+ LDL N+ + + F GL H
Sbjct: 23 VAPQACPAQCSCSGST--VDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRH 80
Query: 451 LVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFL 510
L L L I+ +E GA L L L L+ N L G +L L L N+
Sbjct: 81 LRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQ 140
Query: 511 QVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARE 570
+P A R + +L L N + + G R L + L+ N IT +S+ + +
Sbjct: 141 AIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPK 200
Query: 571 LEKLHLDRNQL 581
L L N L
Sbjct: 201 LRTFRLHSNNL 211
Score = 81.6 bits (200), Expect = 2e-15
Identities = 98/418 (23%), Positives = 150/418 (35%), Gaps = 76/418 (18%)
Query: 115 LNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLP 174
++ ++ L ++P+ LR E LE G F L L +N ++N + +
Sbjct: 517 VDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEAT--GIFKKLPQLRKINFSNNKITDIE 574
Query: 175 AMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLAR 234
AF+G V + L+ N L + + GL +L+ L L N
Sbjct: 575 EGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNR----------------- 617
Query: 235 LELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP 294
+T G + + L +R L L + + P AF DTL
Sbjct: 618 -------ITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAF----------------DTL- 653
Query: 295 PLQGPGQLRRLRLQGNPLWCGCQARPLLEWLARAR-VRSDGACQGPRRLRGEALDALRPW 353
L L L NP C C L EWL + R V + CQ P L+ + +
Sbjct: 654 -----HSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQ 708
Query: 354 DLRCPGDAAQEEEELEERAVAGPRAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEG 413
D C D ++ ++ CP C C+ C
Sbjct: 709 DFTC--DDGNDDNSCS----------------------PLSRCPTECTCL--DTVVRCSN 742
Query: 414 CGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLG 473
GL+ +P+G P D L L N F VP+ HL + L + I+ L + + +
Sbjct: 743 KGLKVLPKGIPRDVTELYLDGNQFTLVPK-ELSNYKHLTLIDLSNNRISTLSNQSFSNMT 801
Query: 474 RLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDN 531
+L+ L LS N+L + +G L L L N VP A L +L L + N
Sbjct: 802 QLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGAN 859
Score = 79.0 bits (193), Expect = 2e-14
Identities = 103/411 (25%), Positives = 155/411 (37%), Gaps = 113/411 (27%)
Query: 33 CPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAA-FQGVPHLTHL 91
CP+ C C+ + V C Q L ++P+ IP+ T L L N V+ A F+ +P L +
Sbjct: 506 CPEKCRCEGTT--VDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKI 563
Query: 92 DLRHCEVELVAEGA------------------------FRGLGRLLLLNLASNHLRELPQ 127
+ + ++ + EGA F+GL L L L SN + +
Sbjct: 564 NFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGN 623
Query: 128 EALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWL 187
++ GL S+R L L N + + PG F L +L+TLNL N +A+ G WL
Sbjct: 624 DSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLG----EWL 679
Query: 188 RLSH-----------------------------------NALSVLA--PEALAGLPALRR 210
R N+ S L+ P L + R
Sbjct: 680 RKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDTVVR 739
Query: 211 LSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELL---LDGGALQ 267
S + L+ LP + R + L L N T +E L + L L +
Sbjct: 740 CS--NKGLKVLPKGI---PRDVTELYLDGNQFTLVPKE----LSNYKHLTLIDLSNNRIS 790
Query: 268 ALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQG---------------- 309
L ++F++ +L TL L N+L +PP G LR L L G
Sbjct: 791 TLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSA 850
Query: 310 --------NPLWCGCQARPLLEWLARARVRSDG--ACQGPRRLRGEALDAL 350
NPL+C C + L +W+ ++ + G C GP GE D L
Sbjct: 851 LSHLAIGANPLYCDCNMQWLSDWV-KSEYKEPGIARCAGP----GEMADKL 896
Score = 77.0 bits (188), Expect = 6e-14
Identities = 67/208 (32%), Positives = 97/208 (46%), Gaps = 12/208 (5%)
Query: 514 GAALRALP-----SLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPA 568
G ALR++P + L L N + R+ D R LR + L N+I+ + GA
Sbjct: 43 GLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDL 102
Query: 569 RELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSS 628
+ELE+L L+RN L+ P G L L LS N ++A+ AF+ +++L L+ +
Sbjct: 103 KELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRG-AVDIKNLQLDYN 161
Query: 629 GLEQICPGAFSGLGPGLQSLHLQKNQLRAL--PALPSLSQLELIDLSSNPFHCDCQLLPL 686
+ I GAF L L+ L L N + L + + +L L SN +CDC L L
Sbjct: 162 QISCIEDGAFRAL-RDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWL 220
Query: 687 HRWLTGLNLRVG--ATCATPPNARGQRV 712
WL RVG C P + RG V
Sbjct: 221 SDWLR-QRPRVGLYTQCMGPSHLRGHNV 247
Score = 76.3 bits (186), Expect = 1e-13
Identities = 48/139 (34%), Positives = 68/139 (48%), Gaps = 3/139 (2%)
Query: 32 RCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQGVPHLTHL 91
RCP C C ++ V C + L +P IP L L GN ++P HLT +
Sbjct: 726 RCPTECTCLDTV--VRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKE-LSNYKHLTLI 782
Query: 92 DLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRP 151
DL + + ++ +F + +LL L L+ N LR +P DGL SLR L L GN + +
Sbjct: 783 DLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPE 842
Query: 152 GTFGALGALATLNLAHNAL 170
G F L AL+ L + N L
Sbjct: 843 GAFNDLSALSHLAIGANPL 861
Score = 73.6 bits (179), Expect = 7e-13
Identities = 62/212 (29%), Positives = 94/212 (44%), Gaps = 30/212 (14%)
Query: 507 NRFLQVPGAALRALPS-----LFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVS 561
N + G L +P+ + + L+ N + + PG + LR + LS N+I+E++
Sbjct: 281 NNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELA 340
Query: 562 LGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQ 621
A R L L L N++ E+P EGL +L L L+ N + LR AFQ + +L
Sbjct: 341 PDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDL-HNLN 399
Query: 622 HLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSNPFHCDC 681
L L + L+ I G FS L +Q++H L+ NPF CDC
Sbjct: 400 LLSLYDNKLQTIAKGTFSPL-RAIQTMH----------------------LAQNPFICDC 436
Query: 682 QLLPLHRWL-TGLNLRVGATCATPPNARGQRV 712
L L +L T GA C +P +R+
Sbjct: 437 HLKWLADYLHTNPIETSGARCTSPRRLANKRI 468
>gi|12007646 nyctalopin precursor [Homo sapiens]
Length = 481
Score = 132 bits (331), Expect = 2e-30
Identities = 114/343 (33%), Positives = 150/343 (43%), Gaps = 32/343 (9%)
Query: 396 CPRACVCVPESRHSS--CEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVS 453
CP AC C R S C+ GL VP P + +DL RN + AF L L
Sbjct: 31 CPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLRR 90
Query: 454 LHLQHCGIAELEAGALAGLGRLIYLYLSDN---------------QLAGLSAAA------ 492
L L+H ++ + GA GL RL L L+ N +L L AA
Sbjct: 91 LSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSV 150
Query: 493 ----LEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALR 548
L P L L N F +VPG ALR L +L HL+ ++ +A L R LR
Sbjct: 151 PERLLAELPALRELAAFDNLFRRVPG-ALRGLANLTHAHLERGRIEAVASSSLQGLRRLR 209
Query: 549 WVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRAL 608
+ L NR+ V GA G LE L L+ N L E+P A GL L L L GN L +
Sbjct: 210 SLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRV 269
Query: 609 RDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQ 666
F + L+ L+L+ + + + GAF L GL +LHL N+L L A
Sbjct: 270 ARAWFADLA-ELELLYLDRNSIAFVEEGAFQNLS-GLLALHLNGNRLTVLAWVAFQPGFF 327
Query: 667 LELIDLSSNPFHCDCQLLPLHRWLTGLNLRVGATCATPPNARG 709
L + L NP+ CDC+L L W+ G CA+P + G
Sbjct: 328 LGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVPCASPGSVAG 370
Score = 119 bits (299), Expect = 8e-27
Identities = 115/364 (31%), Positives = 147/364 (40%), Gaps = 31/364 (8%)
Query: 12 LVLPLLVLLLLAP---ARQAAAQRCPQACICDNSRR--HVACRYQNLTEVPDAIPELTQR 66
LVL L ++L P A A A+ CP AC C R V C L VP +P
Sbjct: 7 LVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVS 66
Query: 67 LDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASN-HLREL 125
+DL N L+ + AF +P L L LRH + + GAF+GL RL L LA N LR L
Sbjct: 67 IDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYL 126
Query: 126 PQEALDGLGSLRRLEL--------------EGNALEELR---------PGTFGALGALAT 162
L LRRL+L E AL EL PG L L
Sbjct: 127 HARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTH 186
Query: 163 LNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALP 222
+L + + + + QGL R+R L L N + + A L L L+ N L LP
Sbjct: 187 AHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELP 246
Query: 223 GPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHT 282
R L L LG N L L L L LD ++ + AF + L
Sbjct: 247 ADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLA 306
Query: 283 LDLRGNQLDTLP--PLQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRSDGACQGPR 340
L L GN+L L Q L RL L NP C C+ L +W+ + +D C P
Sbjct: 307 LHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVPCASPG 366
Query: 341 RLRG 344
+ G
Sbjct: 367 SVAG 370
>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
[Homo sapiens]
Length = 518
Score = 130 bits (328), Expect = 3e-30
Identities = 103/351 (29%), Positives = 163/351 (46%), Gaps = 11/351 (3%)
Query: 10 VPLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDL 69
V ++LP L+L++L A++A CP+ C CD + V C ++P+ I +Q L L
Sbjct: 15 VLVLLPTLLLVMLTGAQRA----CPKNCRCDG--KIVYCESHAFADIPENISGGSQGLSL 68
Query: 70 QGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEA 129
+ N ++ + + F G+ L L L H + V E AF+G+ RL L L+SN + L +
Sbjct: 69 RFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKT 128
Query: 130 LDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRL 189
+ +LR L+L N L+ L+ F L L L+L N+L +P FQ + +L L
Sbjct: 129 FHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDL 188
Query: 190 SHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEED 249
+N L L+ A AGL L+ L L HN+ + + L + L N + +
Sbjct: 189 GYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGL 248
Query: 250 GLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTL--PPLQGPGQLRRLRL 307
L L L G +Q + P F P L L+L N+L + + L + L
Sbjct: 249 TWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITL 308
Query: 308 QGNPLWCGCQARPLLEWLA--RARVRSDGACQGPRRLRGEAL-DALRPWDL 355
GN C PL WL + S C GP+ ++GE + DA+ +++
Sbjct: 309 SGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNI 359
Score = 121 bits (304), Expect = 2e-27
Identities = 96/339 (28%), Positives = 149/339 (43%), Gaps = 11/339 (3%)
Query: 388 GEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPG 447
G +RA CP+ C C + + CE +P +Q L LR N + F G
Sbjct: 29 GAQRA---CPKNCRC--DGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAG 83
Query: 448 LGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERN 507
L L+ L+L H I+ ++ A G+ RL L LS N++ L P L L L N
Sbjct: 84 LNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYN 143
Query: 508 RFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGP 567
+ + + L L LHL+ N++ + R L ++ L NR+ +S A
Sbjct: 144 KLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAG 203
Query: 568 ARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNS 627
+L++LHL+ NQ ++ L L + L N +R++ G SL +L L+
Sbjct: 204 LLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQG-LTWTWSSLHNLDLSG 262
Query: 628 SGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELID--LSSNPFHCDCQLLP 685
+ ++ I PG F L P LQ L+L N+L + + + LI LS N + C + P
Sbjct: 263 NDIQGIEPGTFKCL-PNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECSRSICP 321
Query: 686 LHRWLTGL--NLRVGATCATPPNARGQRVKAAAAVFEDC 722
L WL N CA P + +G++V A + C
Sbjct: 322 LFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC 360
>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
[Homo sapiens]
Length = 590
Score = 130 bits (328), Expect = 3e-30
Identities = 103/351 (29%), Positives = 163/351 (46%), Gaps = 11/351 (3%)
Query: 10 VPLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDL 69
V ++LP L+L++L A++A CP+ C CD + V C ++P+ I +Q L L
Sbjct: 15 VLVLLPTLLLVMLTGAQRA----CPKNCRCDG--KIVYCESHAFADIPENISGGSQGLSL 68
Query: 70 QGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEA 129
+ N ++ + + F G+ L L L H + V E AF+G+ RL L L+SN + L +
Sbjct: 69 RFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKT 128
Query: 130 LDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRL 189
+ +LR L+L N L+ L+ F L L L+L N+L +P FQ + +L L
Sbjct: 129 FHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDL 188
Query: 190 SHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEED 249
+N L L+ A AGL L+ L L HN+ + + L + L N + +
Sbjct: 189 GYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGL 248
Query: 250 GLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTL--PPLQGPGQLRRLRL 307
L L L G +Q + P F P L L+L N+L + + L + L
Sbjct: 249 TWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITL 308
Query: 308 QGNPLWCGCQARPLLEWLA--RARVRSDGACQGPRRLRGEAL-DALRPWDL 355
GN C PL WL + S C GP+ ++GE + DA+ +++
Sbjct: 309 SGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNI 359
Score = 121 bits (304), Expect = 2e-27
Identities = 96/339 (28%), Positives = 149/339 (43%), Gaps = 11/339 (3%)
Query: 388 GEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPG 447
G +RA CP+ C C + + CE +P +Q L LR N + F G
Sbjct: 29 GAQRA---CPKNCRC--DGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAG 83
Query: 448 LGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERN 507
L L+ L+L H I+ ++ A G+ RL L LS N++ L P L L L N
Sbjct: 84 LNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYN 143
Query: 508 RFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGP 567
+ + + L L LHL+ N++ + R L ++ L NR+ +S A
Sbjct: 144 KLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAG 203
Query: 568 ARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNS 627
+L++LHL+ NQ ++ L L + L N +R++ G SL +L L+
Sbjct: 204 LLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQG-LTWTWSSLHNLDLSG 262
Query: 628 SGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELID--LSSNPFHCDCQLLP 685
+ ++ I PG F L P LQ L+L N+L + + + LI LS N + C + P
Sbjct: 263 NDIQGIEPGTFKCL-PNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECSRSICP 321
Query: 686 LHRWLTGL--NLRVGATCATPPNARGQRVKAAAAVFEDC 722
L WL N CA P + +G++V A + C
Sbjct: 322 LFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC 360
>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
Length = 473
Score = 130 bits (327), Expect = 5e-30
Identities = 116/344 (33%), Positives = 150/344 (43%), Gaps = 50/344 (14%)
Query: 16 LLVLLLLAPARQAAAQRCPQACICDNSRR-HVACRYQNLTEVPDAIPELTQRLDLQGNLL 74
LL +L A Q AA CP AC+C N + +C Q L VP IP +QR+ L GN +
Sbjct: 11 LLAWVLWLQAWQVAAP-CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRI 69
Query: 75 KVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASN-HLRELPQEALDGL 133
+PAA+F+ +LT L L + + AF GL L L+L+ N LR + GL
Sbjct: 70 SHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGL 129
Query: 134 GSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNA 193
G L L L+ L+EL PG F L AL L L NAL LP F+ L + L L N
Sbjct: 130 GRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNR 189
Query: 194 LSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLAL 253
+S + A GL +L RL LH N + + L L L N L+ AL
Sbjct: 190 ISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS--------AL 241
Query: 254 PGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLW 313
P + L PL+ L+ LRL NP
Sbjct: 242 P-----------------------------------TEALAPLRA---LQYLRLNDNPWV 263
Query: 314 CGCQARPLLEWLARAR-VRSDGACQGPRRLRGEALDALRPWDLR 356
C C+ARPL WL + R S+ C P+RL G L L DL+
Sbjct: 264 CDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQ 307
Score = 125 bits (314), Expect = 1e-28
Identities = 112/362 (30%), Positives = 150/362 (41%), Gaps = 64/362 (17%)
Query: 391 RAVAPCPRACVCVPESR-HSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLG 449
+ APCP ACVC E + +SC GLQAVP G P+ +Q + L N VP A+F
Sbjct: 22 QVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACR 81
Query: 450 HLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDN-QLAGLSAAALEGAPRLGYLYLERNR 508
+L L L +A ++A A GL L L LSDN QL + A G RL L+L+R
Sbjct: 82 NLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCG 141
Query: 509 FLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPA 568
++ R L +L L+LQDNA+ L L ++L GNRI+ V A
Sbjct: 142 LQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGL 201
Query: 569 RELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSS 628
L++L L +N++ V A L L+ L L N L AL A P+ R+LQ+L LN
Sbjct: 202 HSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPL-RALQYLRLN-- 258
Query: 629 GLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSNPFHCDCQLLPLHR 688
NP+ CDC+ PL
Sbjct: 259 ---------------------------------------------DNPWVCDCRARPLWA 273
Query: 689 WL---TGLNLRVGATCATPPNARGQRVKAAAA-VFEDC--------PGWAARKAKRTPAS 736
WL G + V C+ P G+ +K AA + C P W R P
Sbjct: 274 WLQKFRGSSSEV--PCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLG 331
Query: 737 RP 738
P
Sbjct: 332 LP 333
>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
sapiens]
Length = 581
Score = 130 bits (327), Expect = 5e-30
Identities = 113/384 (29%), Positives = 172/384 (44%), Gaps = 14/384 (3%)
Query: 6 SSTHVPLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQ 65
S + V LV+ VLL + +A + CP+ C C+ + V C Q L E+P +I
Sbjct: 10 SGSAVALVIAPTVLLTML---SSAERGCPKGCRCEG--KMVYCESQKLQEIPSSISAGCL 64
Query: 66 RLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLREL 125
L L+ N L+ + F+G+ LT L L H + + E AF G+ RL L L+SN +
Sbjct: 65 GLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYF 124
Query: 126 PQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVR 185
+ +LR L+L N L L F L L +L+L N+L +P FQ +
Sbjct: 125 LNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLE 184
Query: 186 WLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYA 245
L L +N + LA AG+ L+ L L HN+ L + + L L L N ++
Sbjct: 185 LLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVI 244
Query: 246 GEEDGLALPGLRELLLDGGALQAL-GPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQL 302
G+ L+ L L G ++A GP F P L L+L N+L + L L
Sbjct: 245 GQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISL 304
Query: 303 RRLRLQGNPLWCGCQARPLLEWLARARVRSDGA--CQGPRRLRG-EALDALRPWDLRCPG 359
+ L GN C L+ WL + + C P+ L+G +DA++ + + C G
Sbjct: 305 NDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSI-C-G 362
Query: 360 DAAQEEEELEERAVAGPRAPPRGP 383
+ E +L RA+ P P+ P
Sbjct: 363 KSTTERFDL-ARALPKPTFKPKLP 385
Score = 103 bits (256), Expect = 8e-22
Identities = 91/331 (27%), Positives = 134/331 (40%), Gaps = 7/331 (2%)
Query: 396 CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLH 455
CP+ C C E + CE LQ +P + L LR N + F GL L L+
Sbjct: 34 CPKGCRC--EGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLY 91
Query: 456 LQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGA 515
L H I+ ++ A G+ RL L LS N+++ L L L N+ +
Sbjct: 92 LDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSE 151
Query: 516 ALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLH 575
R L L SLHL+ N++ + R L + L NRI ++ L++LH
Sbjct: 152 QFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELH 211
Query: 576 LDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICP 635
L+ NQ ++ L +L L L N + + SLQ L L+ + +E
Sbjct: 212 LEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQ-TMSWTWSSLQRLDLSGNEIEAFSG 270
Query: 636 GAFSGLGPGLQSLHLQKNQLRAL--PALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGL 693
+ P LQ L+L N+L + L S L I L+ N + C + L WL
Sbjct: 271 PSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLKSF 330
Query: 694 -NLRVGA-TCATPPNARGQRVKAAAAVFEDC 722
LR CA+P +G V A + C
Sbjct: 331 KGLRENTIICASPKELQGVNVIDAVKNYSIC 361
>gi|88702793 slit-like 2 [Homo sapiens]
Length = 673
Score = 130 bits (326), Expect = 6e-30
Identities = 132/423 (31%), Positives = 173/423 (40%), Gaps = 36/423 (8%)
Query: 8 THVPLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRL 67
+ VPL+LPLL+LL L P Q CP C C + V C + T VP +P T L
Sbjct: 3 SRVPLLLPLLLLLALGPG----VQGCPSGCQCSQPQT-VFCTARQGTTVPRDVPPDTVGL 57
Query: 68 DLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQ 127
+ N + ++ A +F G+P L LDL ++ + G F+ L L L+L +N L E+
Sbjct: 58 YVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITN 117
Query: 128 EALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWL 187
E GL L RL L N + ++PG F L L L L N L LP + L R+ L
Sbjct: 118 ETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLR---LPRLLLL 174
Query: 188 RLSHNALSVLAPEAL--AGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYA 245
LSHN+L L P L A + ALR L LQ L + S+ R L L++ N L
Sbjct: 175 DLSHNSLLALEPGILDTANVEALRLAGL---GLQQLDEGLFSRLRNLHDLDVSDNQLERV 231
Query: 246 GEEDGLALPGLRELLLDGGA-LQALGPRAFAHCPRLHTLDLRGNQLDTLP-PLQGP-GQL 302
L GL L L G + L P A L LD+ L LP L G +L
Sbjct: 232 PPVI-RGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRL 290
Query: 303 RRLRLQGNPLWCGCQARPLLEWLARARVR----SDGACQGPRRLRGEALDALRPWDLRCP 358
R L NP C C W+ + V + C P + G L L D CP
Sbjct: 291 RLLAAARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCP 350
Query: 359 GDAAQEEEEL------EERAVAGPRAPPRGPPRGPGEER---------AVAPCPRACVCV 403
E A++ AP P P E V P P+ C
Sbjct: 351 ATTTTATVPTTRPVVREPTALSSSLAPTWLSPTEPATEAPSPPSTAPPTVGPVPQPQDCP 410
Query: 404 PES 406
P +
Sbjct: 411 PST 413
Score = 101 bits (252), Expect = 2e-21
Identities = 108/366 (29%), Positives = 151/366 (41%), Gaps = 27/366 (7%)
Query: 386 GPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAF 445
GPG V CP C C + + C VPR P DT L + N + +F
Sbjct: 18 GPG----VQGCPSGCQC-SQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDAGSF 72
Query: 446 PGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLE 505
GL L L L IA L +G L L L L+ N+L ++ G RL LYL
Sbjct: 73 AGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLG 132
Query: 506 RNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGAL 565
+NR + A L L L LQDN + L P L R L + LS N + + G L
Sbjct: 133 KNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPR---LLLLDLSHNSLLALEPGIL 189
Query: 566 GPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHL-- 623
A +E L L L+++ G L L +L +S N L + PV R L+ L
Sbjct: 190 DTA-NVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERV-----PPVIRGLRGLTR 243
Query: 624 --FLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPS--LSQLELIDLSSNPFHC 679
++ + Q+ P +GL LQ L + L+ALP S +L L+ + NPF+C
Sbjct: 244 LRLAGNTRIAQLRPEDLAGLA-ALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNC 302
Query: 680 DCQLLPLHRWLTGLNLRVGA----TCATPPNARGQRVKAAAAVFEDCPGWAARKAKRTPA 735
C L W+ ++ + + C PP G+ + CP A P
Sbjct: 303 VCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCP--ATTTTATVPT 360
Query: 736 SRPSAR 741
+RP R
Sbjct: 361 TRPVVR 366
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 129 bits (325), Expect = 8e-30
Identities = 106/322 (32%), Positives = 145/322 (45%), Gaps = 32/322 (9%)
Query: 396 CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLH 455
CP C C + C L+ VP G ++T+LL+L N + +F L HL L
Sbjct: 47 CPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQ 106
Query: 456 LQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGA 515
L I +E GA GL L L L DN+L + A +L L+L N +P
Sbjct: 107 LSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSY 166
Query: 516 ALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLH 575
A +PSL L DLG + R++ +S GA L L+
Sbjct: 167 AFNRIPSLRRL-------------DLGELK----------RLSYISEGAFEGLSNLRYLN 203
Query: 576 LDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICP 635
L LRE+P L L L EL LSGN L A+R G+FQ + LQ L++ S ++ I
Sbjct: 204 LAMCNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGL-MHLQKLWMIQSQIQVIER 260
Query: 636 GAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGL 693
AF L L ++L N L LP L LE I L NP++C+C +L L W+ +
Sbjct: 261 NAFDNL-QSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDM 319
Query: 694 ---NLRVGATCATPPNARGQRV 712
N A C TPPN +G+ +
Sbjct: 320 APSNTACCARCNTPPNLKGRYI 341
Score = 123 bits (308), Expect = 7e-28
Identities = 111/361 (30%), Positives = 158/361 (43%), Gaps = 40/361 (11%)
Query: 1 MEGPRSSTHV--PLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPD 58
M GPR + + PL++ LL L LL A AQ CP C C N V C +NL EVPD
Sbjct: 13 MIGPRFNRALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPD 72
Query: 59 AIPELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLA 118
I T+ L+L N +++I +F+ HL HL+ +L L+
Sbjct: 73 GISTNTRLLNLHENQIQIIKVNSFK---HLRHLE---------------------ILQLS 108
Query: 119 SNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAF 178
NH+R + A +GL +L LEL N L + G F L L L L +N + +P+ AF
Sbjct: 109 RNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAF 168
Query: 179 QGLLRVRWLRLSH-NALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLEL 237
+ +R L L LS ++ A GL LR L+L L+ +P L+ L L+L
Sbjct: 169 NRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDL 226
Query: 238 GHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP--- 294
N L+ L L++L + +Q + AF + L ++L N L LP
Sbjct: 227 SGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDL 286
Query: 295 --PLQGPGQLRRLRLQGNPLWCGCQARPLLEW---LARARVRSDGACQGPRRLRGEALDA 349
PL L R+ L NP C C L W +A + C P L+G +
Sbjct: 287 FTPLH---HLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGE 343
Query: 350 L 350
L
Sbjct: 344 L 344
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 128 bits (322), Expect = 2e-29
Identities = 113/374 (30%), Positives = 151/374 (40%), Gaps = 56/374 (14%)
Query: 17 LVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKV 76
++LL+L +A CP C C R V C + VP+ IP T+ LDL N +K
Sbjct: 26 ILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKT 85
Query: 77 IPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSL 136
+ F PHL L+L V V GAF L L L L SN L+ +P GL +L
Sbjct: 86 LNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNL 145
Query: 137 RRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQG---------------- 180
+L++ N + L F L L +L + N LVY+ AF G
Sbjct: 146 TKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTS 205
Query: 181 --------------------------------LLRVRWLRLSH-NALSVLAPEALAGLPA 207
L R++ L +SH L + P L GL
Sbjct: 206 IPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGL-N 264
Query: 208 LRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQ 267
L LS+ H L A+P + L L L +NP++ L L+E+ L GG L
Sbjct: 265 LTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLA 324
Query: 268 ALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNPLWCGCQARPLLEWL 325
+ P AF L L++ GNQL TL G L L L NPL C C+ L W+
Sbjct: 325 VVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCR----LLWV 380
Query: 326 ARARVRSDGACQGP 339
R R R + Q P
Sbjct: 381 FRRRWRLNFNRQQP 394
Score = 100 bits (250), Expect = 4e-21
Identities = 111/376 (29%), Positives = 147/376 (39%), Gaps = 67/376 (17%)
Query: 396 CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLH 455
CP C C + R C AVP G P++T+LLDL +N ++ + F HL L
Sbjct: 42 CPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELE 101
Query: 456 LQHCGIAELEAGAL------------------------AGLGRLIYLYLS---------- 481
L ++ +E GA GL L L +S
Sbjct: 102 LNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDY 161
Query: 482 --------------DNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSL- 526
DN L +S A G L L LE+ +P AL L L L
Sbjct: 162 MFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLR 221
Query: 527 --HLQDNAVDRLAPGDLGRTRALR---WVYLSGNRITEVSLGALGPARELEKLHLDRNQL 581
HL NA+ + L R + L W YL + +T L L L L + L
Sbjct: 222 LRHLNINAIRDYSFKRLYRLKVLEISHWPYL--DTMTPNCLYGLN----LTSLSITHCNL 275
Query: 582 REVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGL 641
VP A+ L L L LS NP+ + + R LQ + L L + P AF GL
Sbjct: 276 TAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLR-LQEIQLVGGQLAVVEPYAFRGL 334
Query: 642 GPGLQSLHLQKNQLRALP--ALPSLSQLELIDLSSNPFHCDCQLLPL--HRWLTGLNLRV 697
L+ L++ NQL L S+ LE + L SNP CDC+LL + RW N R
Sbjct: 335 NY-LRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFN-RQ 392
Query: 698 GATCATPPNARGQRVK 713
TCATP +G+ K
Sbjct: 393 QPTCATPEFVQGKEFK 408
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 128 bits (321), Expect = 2e-29
Identities = 96/290 (33%), Positives = 135/290 (46%), Gaps = 14/290 (4%)
Query: 430 LDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLS 489
L+L +N + F LG+L L L + ++ G GL L L L NQ+ LS
Sbjct: 184 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLS 243
Query: 490 AAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRW 549
L LYL N Q+P + LP L L L N++ L+ G G LR
Sbjct: 244 PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRE 303
Query: 550 VYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALR 609
++L N I+ + R+L+ L L RNQ+ + GA GL L EL L N L+ L
Sbjct: 304 LWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLD 363
Query: 610 DGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPA-----LPSL 664
F+ + +LQ++ L ++ L Q+ F+ + GL ++ LQ NQL LP L L
Sbjct: 364 GNVFRMLA-NLQNISLQNNRLRQLPGNIFANVN-GLMAIQLQNNQLENLPLGIFDHLGKL 421
Query: 665 SQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVGA----TCATPPNARGQ 710
+L L D NP+ CD +LPL WL R+G C +P N RGQ
Sbjct: 422 CELRLYD---NPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQ 468
Score = 119 bits (299), Expect = 8e-27
Identities = 99/313 (31%), Positives = 138/313 (44%), Gaps = 30/313 (9%)
Query: 65 QRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRE 124
+ L L GN L+ IP AF + LT L+L + ++ F+ LG L +L L N L +
Sbjct: 158 KELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTD 217
Query: 125 LPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRV 184
+P DGL +L+ L L+ N + L PG F L L L++N + LP F L ++
Sbjct: 218 IPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQL 277
Query: 185 RWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTY 244
L L N+L L+ +P LR L L+ N + +LP V S R L L L N +++
Sbjct: 278 NRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISF 337
Query: 245 AGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP---------- 294
L LREL L ALQ L F L + L+ N+L LP
Sbjct: 338 ISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGL 397
Query: 295 -------------PL---QGPGQLRRLRLQGNPLWCGCQARPLLEWLA--RARVRSD--G 334
PL G+L LRL NP C PL WL + R+ +D
Sbjct: 398 MAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVP 457
Query: 335 ACQGPRRLRGEAL 347
C P +RG++L
Sbjct: 458 VCFSPANVRGQSL 470
Score = 112 bits (279), Expect = 2e-24
Identities = 91/310 (29%), Positives = 130/310 (41%), Gaps = 30/310 (9%)
Query: 14 LPLLVLLLLAPARQA-----AAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLD 68
+PL LLL QA A CP C C + + V C + VP +P L
Sbjct: 7 MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQ 65
Query: 69 LQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQE 128
+ + + + F + L L + E+ + GAFR LG L L+LA+N L+ LP
Sbjct: 66 ILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIG 125
Query: 129 ALDGLGSL------------------------RRLELEGNALEELRPGTFGALGALATLN 164
GL SL + L+L GN LE + G F L L LN
Sbjct: 126 LFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLN 185
Query: 165 LAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGP 224
L N+L ++ FQ L ++ LRL N L+ + GL L+ L+L N++ L
Sbjct: 186 LGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPG 245
Query: 225 VLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLD 284
+ L RL L +N ++ + LP L L L G +L+ L F P L L
Sbjct: 246 LFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELW 305
Query: 285 LRGNQLDTLP 294
L N + +LP
Sbjct: 306 LYDNHISSLP 315
Score = 112 bits (279), Expect = 2e-24
Identities = 85/288 (29%), Positives = 130/288 (45%), Gaps = 10/288 (3%)
Query: 396 CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLH 455
CP C C S+ C G + AVP P + L + H + + F + L++L
Sbjct: 31 CPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALR 89
Query: 456 LQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGA 515
++ ++ + GA LG L YL L++N+L L +G L L L N+ LQ+ A
Sbjct: 90 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 149
Query: 516 ALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLH 575
+L L L N ++ + G L + L N +T +S L+ L
Sbjct: 150 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 209
Query: 576 LDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICP 635
L N+L ++P G +GL L EL L N + L G F +LQ L+L+++ + Q+ P
Sbjct: 210 LYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN-NHNLQRLYLSNNHISQLPP 268
Query: 636 GAFSGLGPGLQSLHLQKNQLRALP-----ALPSLSQLELID--LSSNP 676
F L P L L L N L+ L +P+L +L L D +SS P
Sbjct: 269 SIFMQL-PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 315
Score = 94.0 bits (232), Expect = 5e-19
Identities = 75/227 (33%), Positives = 99/227 (43%), Gaps = 32/227 (14%)
Query: 115 LNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLP 174
L + + H+ EL + + +L L +E N L + PG F LG+L L+LA+N L LP
Sbjct: 64 LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 123
Query: 175 AMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLAR 234
FQGL + L LS N L + P + L+ L LH N L+ +P GL +
Sbjct: 124 IGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTK 183
Query: 235 LELGHNPLTY--------------------------AGEEDGLALPGLRELLLDGGALQA 268
L LG N LT+ G DGL L+EL L +
Sbjct: 184 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLV--NLQELALQQNQIGL 241
Query: 269 LGPRAFAHCPRLHTLDLRGNQLDTLPP---LQGPGQLRRLRLQGNPL 312
L P F + L L L N + LPP +Q P QL RL L GN L
Sbjct: 242 LSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLP-QLNRLTLFGNSL 287
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 128 bits (321), Expect = 2e-29
Identities = 96/290 (33%), Positives = 135/290 (46%), Gaps = 14/290 (4%)
Query: 430 LDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLS 489
L+L +N + F LG+L L L + ++ G GL L L L NQ+ LS
Sbjct: 178 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLS 237
Query: 490 AAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRW 549
L LYL N Q+P + LP L L L N++ L+ G G LR
Sbjct: 238 PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRE 297
Query: 550 VYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALR 609
++L N I+ + R+L+ L L RNQ+ + GA GL L EL L N L+ L
Sbjct: 298 LWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLD 357
Query: 610 DGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPA-----LPSL 664
F+ + +LQ++ L ++ L Q+ F+ + GL ++ LQ NQL LP L L
Sbjct: 358 GNVFRMLA-NLQNISLQNNRLRQLPGNIFANVN-GLMAIQLQNNQLENLPLGIFDHLGKL 415
Query: 665 SQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVGA----TCATPPNARGQ 710
+L L D NP+ CD +LPL WL R+G C +P N RGQ
Sbjct: 416 CELRLYD---NPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQ 462
Score = 119 bits (299), Expect = 8e-27
Identities = 99/313 (31%), Positives = 138/313 (44%), Gaps = 30/313 (9%)
Query: 65 QRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRE 124
+ L L GN L+ IP AF + LT L+L + ++ F+ LG L +L L N L +
Sbjct: 152 KELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTD 211
Query: 125 LPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRV 184
+P DGL +L+ L L+ N + L PG F L L L++N + LP F L ++
Sbjct: 212 IPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQL 271
Query: 185 RWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTY 244
L L N+L L+ +P LR L L+ N + +LP V S R L L L N +++
Sbjct: 272 NRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISF 331
Query: 245 AGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP---------- 294
L LREL L ALQ L F L + L+ N+L LP
Sbjct: 332 ISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGL 391
Query: 295 -------------PL---QGPGQLRRLRLQGNPLWCGCQARPLLEWLA--RARVRSD--G 334
PL G+L LRL NP C PL WL + R+ +D
Sbjct: 392 MAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVP 451
Query: 335 ACQGPRRLRGEAL 347
C P +RG++L
Sbjct: 452 VCFSPANVRGQSL 464
Score = 112 bits (279), Expect = 2e-24
Identities = 91/310 (29%), Positives = 130/310 (41%), Gaps = 30/310 (9%)
Query: 14 LPLLVLLLLAPARQA-----AAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLD 68
+PL LLL QA A CP C C + + V C + VP +P L
Sbjct: 1 MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQ 59
Query: 69 LQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQE 128
+ + + + F + L L + E+ + GAFR LG L L+LA+N L+ LP
Sbjct: 60 ILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIG 119
Query: 129 ALDGLGSL------------------------RRLELEGNALEELRPGTFGALGALATLN 164
GL SL + L+L GN LE + G F L L LN
Sbjct: 120 LFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLN 179
Query: 165 LAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGP 224
L N+L ++ FQ L ++ LRL N L+ + GL L+ L+L N++ L
Sbjct: 180 LGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPG 239
Query: 225 VLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLD 284
+ L RL L +N ++ + LP L L L G +L+ L F P L L
Sbjct: 240 LFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELW 299
Query: 285 LRGNQLDTLP 294
L N + +LP
Sbjct: 300 LYDNHISSLP 309
Score = 112 bits (279), Expect = 2e-24
Identities = 85/288 (29%), Positives = 130/288 (45%), Gaps = 10/288 (3%)
Query: 396 CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLH 455
CP C C S+ C G + AVP P + L + H + + F + L++L
Sbjct: 25 CPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALR 83
Query: 456 LQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGA 515
++ ++ + GA LG L YL L++N+L L +G L L L N+ LQ+ A
Sbjct: 84 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143
Query: 516 ALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLH 575
+L L L N ++ + G L + L N +T +S L+ L
Sbjct: 144 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 203
Query: 576 LDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICP 635
L N+L ++P G +GL L EL L N + L G F +LQ L+L+++ + Q+ P
Sbjct: 204 LYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN-NHNLQRLYLSNNHISQLPP 262
Query: 636 GAFSGLGPGLQSLHLQKNQLRALP-----ALPSLSQLELID--LSSNP 676
F L P L L L N L+ L +P+L +L L D +SS P
Sbjct: 263 SIFMQL-PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 309
Score = 94.0 bits (232), Expect = 5e-19
Identities = 75/227 (33%), Positives = 99/227 (43%), Gaps = 32/227 (14%)
Query: 115 LNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLP 174
L + + H+ EL + + +L L +E N L + PG F LG+L L+LA+N L LP
Sbjct: 58 LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 117
Query: 175 AMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLAR 234
FQGL + L LS N L + P + L+ L LH N L+ +P GL +
Sbjct: 118 IGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTK 177
Query: 235 LELGHNPLTY--------------------------AGEEDGLALPGLRELLLDGGALQA 268
L LG N LT+ G DGL L+EL L +
Sbjct: 178 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLV--NLQELALQQNQIGL 235
Query: 269 LGPRAFAHCPRLHTLDLRGNQLDTLPP---LQGPGQLRRLRLQGNPL 312
L P F + L L L N + LPP +Q P QL RL L GN L
Sbjct: 236 LSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLP-QLNRLTLFGNSL 281
>gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
Length = 441
Score = 128 bits (321), Expect = 2e-29
Identities = 124/413 (30%), Positives = 160/413 (38%), Gaps = 60/413 (14%)
Query: 18 VLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVI 77
+LLLL A CP+ C+C + V+C+ N +P+ IP ++R+ LQ N + ++
Sbjct: 10 LLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLL 69
Query: 78 PAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNH-LRELPQEALDGLGSL 136
F P + L + + + F G L L+L N LR L E GL L
Sbjct: 70 QPGHFS--PAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKL 127
Query: 137 RRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSV 196
L L L L G FG L +L L L N + YL F L+ + L L N L
Sbjct: 128 HALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWS 187
Query: 197 LAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGL 256
L P GL L RL LH N+LQ + R L L L +N L+
Sbjct: 188 LGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLS------------- 234
Query: 257 RELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLWCGC 316
+L+G + L PL G L LRL GNP CGC
Sbjct: 235 ---------------------------ELQG---ECLAPL---GALEFLRLNGNPWDCGC 261
Query: 317 QARPLLEWLARARVRSDGA-CQGPRRLRGEALDALRPWDLR-CPGDAAQEEEE-----LE 369
+AR L EWL R R S C P G+ L LR D R C G A+ + +
Sbjct: 262 RARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPASPHQIKSHTLTTT 321
Query: 370 ERAVAGPRAPPRGPPRGPGEERAVAPCPRA----CVCVPESRHSSCEGCGLQA 418
+RA P GP R G P R C S G G QA
Sbjct: 322 DRAARKEHHSPHGPTRSKGHPHGPRPGHRKPGKNCTNPRNRNQISKAGAGKQA 374
Score = 88.2 bits (217), Expect = 3e-17
Identities = 88/335 (26%), Positives = 125/335 (37%), Gaps = 53/335 (15%)
Query: 396 CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLH 455
CPR CVC P SC+ A+P G P D++ + L+ N + F +V+L
Sbjct: 25 CPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPA--MVTLW 82
Query: 456 LQHCGIAELEAGALAGLGRLIYLYLSDN-QLAGLSAAALEGAPRLGYLYLERNRFLQVPG 514
+ I + G L L L DN QL L+ +G +L LYL + +P
Sbjct: 83 IYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPA 142
Query: 515 AALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKL 574
L SL L+LQDN ++ L L ++L GN++ + G L++L
Sbjct: 143 GVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRL 202
Query: 575 HLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQIC 634
L NQL+ V A L L L L N L L+ P+G +L+ L LN
Sbjct: 203 LLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLG-ALEFLRLN-------- 253
Query: 635 PGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLN 694
NP+ C C+ L WL
Sbjct: 254 ---------------------------------------GNPWDCGCRARSLWEWLQRFR 274
Query: 695 LRVGAT-CATPPNARGQRVKAAAAV-FEDCPGWAA 727
A C +P GQ +K A F +C G A+
Sbjct: 275 GSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPAS 309
>gi|40217825 slit and trk like 6 [Homo sapiens]
Length = 841
Score = 127 bits (319), Expect = 4e-29
Identities = 141/531 (26%), Positives = 211/531 (39%), Gaps = 74/531 (13%)
Query: 163 LNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALP 222
L+L +N L L F GL + L N ++ + A GL L++L ++HN L+ L
Sbjct: 69 LSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILK 128
Query: 223 GPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHT 282
L L+ +N +T L L+ L+L+ A+++L P F P H
Sbjct: 129 EDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTH- 187
Query: 283 LDLRGNQLDTLPP---LQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRS---DGAC 336
LDLRGNQL TLP L+ G++ L+L+ N C C L WL +S D C
Sbjct: 188 LDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVC 247
Query: 337 QGPRRLRGEALDALRPWDLRCPGDAAQEEEE------------------LEERAVAGPRA 378
P +G L L+ + CP EE E + + + +
Sbjct: 248 NSPPFFKGSILSRLKKESI-CPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKL 306
Query: 379 PPRGPP-----RGPGEERAVAPCPRACVCV---PESRHSSCEGCGLQAVP--RGFPSDTQ 428
P + P P + CP C C P C+ ++++ R P + +
Sbjct: 307 PTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPR 366
Query: 429 LLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGL 488
L L N S+ ++ L LHL + I LE G+ L RL LYL+ N L L
Sbjct: 367 KLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKL 426
Query: 489 SAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALR 548
S G L YLYLE N ++ +P L L+L +N + L P
Sbjct: 427 SKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPH--------- 477
Query: 549 WVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVP-TGALEGLPALLELQLSGNPLRA 607
SG +T K++L NQ +P + L+ L L ++ L NP
Sbjct: 478 --IFSGVPLT--------------KVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDC 521
Query: 608 LRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRAL 658
D + + +Q L N+ + +C PG HL K +L+AL
Sbjct: 522 SCD--LVGLQQWIQKLSKNTVTDDILC------TSPG----HLDKKELKAL 560
Score = 85.9 bits (211), Expect = 1e-16
Identities = 66/217 (30%), Positives = 103/217 (47%), Gaps = 10/217 (4%)
Query: 526 LHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVP 585
L L N + L DL L ++L NRI + G+ L+KL+L+ N L ++
Sbjct: 368 LILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLS 427
Query: 586 TGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGL 645
G GL L L L N ++ + G F P+ + L+ L+LN++ L+ + P FSG+ L
Sbjct: 428 KGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPK-LKVLYLNNNLLQVLPPHIFSGVP--L 484
Query: 646 QSLHLQKNQLRALPALPSLSQLEL---IDLSSNPFHCDCQLLPLHRWLTGLNLRV---GA 699
++L+ NQ LP L L+L IDL NP+ C C L+ L +W+ L+
Sbjct: 485 TKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDI 544
Query: 700 TCATPPNARGQRVKAAAAVFEDCPGWAARKAKRTPAS 736
C +P + + +KA + CPG + T S
Sbjct: 545 LCTSPGHLDKKELKALNSEIL-CPGLVNNPSMPTQTS 580
Score = 78.6 bits (192), Expect = 2e-14
Identities = 56/177 (31%), Positives = 86/177 (48%), Gaps = 5/177 (2%)
Query: 10 VPLVLPLLVLLLLAPARQAAAQRCPQACIC---DNSRRHVACRYQNLTEVPDAIP--ELT 64
+P P L+ + P+ Q CP C C S + C+ +N+ + D P +
Sbjct: 306 LPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNP 365
Query: 65 QRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRE 124
++L L GN++ + + L L L + +E++ EG+F L RL L L NHL +
Sbjct: 366 RKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTK 425
Query: 125 LPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGL 181
L + GL +L L LE NA++E+ PGTF + L L L +N L LP F G+
Sbjct: 426 LSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGV 482
Score = 75.1 bits (183), Expect = 2e-13
Identities = 58/193 (30%), Positives = 90/193 (46%), Gaps = 11/193 (5%)
Query: 524 FSLHLQDNAVDRLAPGDL-GRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLR 582
F L L +N + L D G T A+ ++L N I ++ +GA L++LH++ N L
Sbjct: 67 FQLSLLNNGLTMLHTNDFSGLTNAIS-IHLGFNNIADIEIGAFNGLGLLKQLHINHNSLE 125
Query: 583 EVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLG 642
+ GL L LQ N + + AF + R L+ L LN + +E + P F +
Sbjct: 126 ILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNR-LKVLILNDNAIESLPPNIFRFV- 183
Query: 643 PGLQSLHLQKNQLRALPALPSLSQLELI---DLSSNPFHCDCQLLPLHRWLTGL---NLR 696
L L L+ NQL+ LP + L + I L N + C+C LL L WL + ++
Sbjct: 184 -PLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSII 242
Query: 697 VGATCATPPNARG 709
C +PP +G
Sbjct: 243 GDVVCNSPPFFKG 255
Score = 65.1 bits (157), Expect = 2e-10
Identities = 70/248 (28%), Positives = 95/248 (38%), Gaps = 50/248 (20%)
Query: 115 LNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLP 174
L LA N + L + L +L L L N +E L G+F L L L L N L L
Sbjct: 368 LILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLS 427
Query: 175 AMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLAR 234
F GL + +L L +NA+ + P +P L+ L L++N LQ LP + S
Sbjct: 428 KGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGV----- 482
Query: 235 LELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP 294
PLT L F H P + LD LD
Sbjct: 483 ------PLTKVN----------------------LKTNQFTHLPVSNILD----DLDL-- 508
Query: 295 PLQGPGQLRRLRLQGNPLWCGCQARPLLEW---LARARVRSDGACQGPRRLRGEALDALR 351
L ++ L+ NP C C L +W L++ V D C P L + L AL
Sbjct: 509 -------LTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALN 561
Query: 352 PWDLRCPG 359
++ CPG
Sbjct: 562 S-EILCPG 568
Score = 63.9 bits (154), Expect = 5e-10
Identities = 62/213 (29%), Positives = 87/213 (40%), Gaps = 30/213 (14%)
Query: 396 CPRACVCVPESRHS--SCEGCGLQAVPRGF--PSDTQLLDLRRNHFPSVPRAAFPGLGHL 451
C C C + +CE G++ V PS L L N + F GL +
Sbjct: 31 CDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNA 90
Query: 452 VSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQ 511
+S+HL IA++E GA GLG L L+++ N L L G L +L + N
Sbjct: 91 ISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITV 150
Query: 512 VPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPAREL 571
+ +A L L L L DNA++ L P R+V L
Sbjct: 151 IEPSAFSKLNRLKVLILNDNAIESLPP------NIFRFV-------------------PL 185
Query: 572 EKLHLDRNQLREVP-TGALEGLPALLELQLSGN 603
L L NQL+ +P G LE + +L+LQL N
Sbjct: 186 THLDLRGNQLQTLPYVGFLEHIGRILDLQLEDN 218
>gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 125 bits (314), Expect = 1e-28
Identities = 135/519 (26%), Positives = 196/519 (37%), Gaps = 106/519 (20%)
Query: 138 RLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVL 197
+L L GN L L P F TL+L +N L + AF GL ++ L L++N L +L
Sbjct: 66 QLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEIL 125
Query: 198 APEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLR 257
+ GL +L L +N + A+ S+ L L+
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSK------------------------LNKLK 161
Query: 258 ELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP---PLQGPGQLRRLRLQGNPLWC 314
L+L+ L +L F H LDLRGN+L +P L+ G + ++L+ NP C
Sbjct: 162 VLILNDNLLLSLPSNVFRFVLLTH-LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNC 220
Query: 315 GCQARPLLEWLARARV-RSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERA- 372
C PL WL V + C+ P RL G+ + L DL CP +A + + A
Sbjct: 221 TCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDL-CPRKSASDSSQRGSHAD 279
Query: 373 -----VAGPRAPPRGPPRGPGEER--------------------------------AVAP 395
++ P P R P R
Sbjct: 280 THVQRLSPTMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLT 339
Query: 396 CPRACVCVPESRHSSCEGCGLQAVPRGF---------PSDTQLLDLRRNHFPSVPRAAFP 446
CP +CVC + SS G + R F P+ + L L N+ +V +
Sbjct: 340 CPSSCVCTSQ---SSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLL 396
Query: 447 GLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLER 506
L LHL + IA ++ GA L L LYL+ N L L + +G L YLYLE
Sbjct: 397 EYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEY 456
Query: 507 NRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALG 566
N ++ AL +L L L +N + L G T
Sbjct: 457 NVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGT---------------------- 494
Query: 567 PARELEKLHLDRNQLREVPT-GALEGLPALLELQLSGNP 604
L +L+L N +P G L+ LPA +++ L NP
Sbjct: 495 ---ALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENP 530
Score = 82.0 bits (201), Expect = 2e-15
Identities = 59/194 (30%), Positives = 93/194 (47%), Gaps = 7/194 (3%)
Query: 523 LFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLR 582
++ L L N + RL P + ++L N + E+ GA + L++LHL+ N+L
Sbjct: 64 IYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLE 123
Query: 583 EVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLG 642
+ GL +L LQ N + A+ GAF + + L+ L LN + L + F +
Sbjct: 124 ILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNK-LKVLILNDNLLLSLPSNVFRFV- 181
Query: 643 PGLQSLHLQKNQLRALP---ALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVG- 698
L L L+ N+L+ +P L + + I L NP++C C LLPL WL + + VG
Sbjct: 182 -LLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGE 240
Query: 699 ATCATPPNARGQRV 712
C TP G+ V
Sbjct: 241 IVCETPFRLHGKDV 254
Score = 80.5 bits (197), Expect = 5e-15
Identities = 65/191 (34%), Positives = 92/191 (48%), Gaps = 8/191 (4%)
Query: 33 CPQACICDNSRR----HVACRYQNLTEVPDAIPELT--QRLDLQGNLLKVIPAAAFQGVP 86
CP +C+C + +V C+ + T + D P+ T ++L L GN L+ +
Sbjct: 340 CPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYS 399
Query: 87 HLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNAL 146
L L L + + ++ EGAF L L L L N+L L DGL SL+ L LE N +
Sbjct: 400 SLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 459
Query: 147 EELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPE-ALAGL 205
+E++P TF AL L L L +N L LP F G R L L +N S L + L L
Sbjct: 460 KEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTR-LNLRNNHFSHLPVKGVLDQL 518
Query: 206 PALRRLSLHHN 216
PA ++ L N
Sbjct: 519 PAFIQIDLQEN 529
Score = 66.2 bits (160), Expect = 1e-10
Identities = 61/227 (26%), Positives = 95/227 (41%), Gaps = 30/227 (13%)
Query: 20 LLLAPARQAAAQRCPQACICDNSRR--HVACRYQNLTEVPDAIPELTQ--RLDLQGNLLK 75
+L +R+ A C C+C+ ++ C + T V P + +L L GNLL
Sbjct: 16 ILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLT 75
Query: 76 VIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGS 135
+ F + L L + ++ + GAF GL L L+L +N L L ++ GL S
Sbjct: 76 RLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLES 135
Query: 136 LRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALS 195
L L+ + N + + G F L L L L N L+ LP+ F R++ L+H
Sbjct: 136 LEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVF------RFVLLTH---- 185
Query: 196 VLAPEALAGLPALRRLSLHHNELQALP-GPVLSQARGLARLELGHNP 241
L L N L+ +P VL G+ ++L NP
Sbjct: 186 ---------------LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENP 217
Score = 65.9 bits (159), Expect = 1e-10
Identities = 63/230 (27%), Positives = 90/230 (39%), Gaps = 35/230 (15%)
Query: 502 LYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVS 561
LYL N V L SL LHL +N + + G +LR +YL+GN + +
Sbjct: 380 LYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLY 439
Query: 562 LGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQ 621
+ L+ L+L+ N ++E+ + L L L L+ N LR+L D F
Sbjct: 440 PSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFG------- 492
Query: 622 HLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLEL---IDLSSNPFH 678
G L L+L+ N LP L QL IDL NP+
Sbjct: 493 --------------------GTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWD 532
Query: 679 CDCQLLPLHRWLTGLNLRV---GATCATPPNARGQRVK--AAAAVFEDCP 723
C C ++ L W N V TC +P G+ +K A+ D P
Sbjct: 533 CTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICPDSP 582
Score = 62.0 bits (149), Expect = 2e-09
Identities = 62/222 (27%), Positives = 93/222 (41%), Gaps = 31/222 (13%)
Query: 135 SLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNAL 194
S ++L L GN L+ + +L L+L +N + + AF L +R L L+ N L
Sbjct: 376 SPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYL 435
Query: 195 SVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALP 254
VL P GL +L+ L L +N ++ + PLT+ AL
Sbjct: 436 EVLYPSMFDGLQSLQYLYLEYNVIKEI------------------KPLTFD------ALI 471
Query: 255 GLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLR---RLRLQGNP 311
L+ L L+ L++L F L L+LR N LP QL ++ LQ NP
Sbjct: 472 NLQLLFLNNNLLRSLPDNIFGGTA-LTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENP 530
Query: 312 LWCGCQARPLLEWLARAR---VRSDGACQGPRRLRGEALDAL 350
C C L +W A + ++ C+ P + GE L L
Sbjct: 531 WDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFL 572
>gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 125 bits (314), Expect = 1e-28
Identities = 135/519 (26%), Positives = 196/519 (37%), Gaps = 106/519 (20%)
Query: 138 RLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVL 197
+L L GN L L P F TL+L +N L + AF GL ++ L L++N L +L
Sbjct: 66 QLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEIL 125
Query: 198 APEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLR 257
+ GL +L L +N + A+ S+ L L+
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSK------------------------LNKLK 161
Query: 258 ELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP---PLQGPGQLRRLRLQGNPLWC 314
L+L+ L +L F H LDLRGN+L +P L+ G + ++L+ NP C
Sbjct: 162 VLILNDNLLLSLPSNVFRFVLLTH-LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNC 220
Query: 315 GCQARPLLEWLARARV-RSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERA- 372
C PL WL V + C+ P RL G+ + L DL CP +A + + A
Sbjct: 221 TCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDL-CPRKSASDSSQRGSHAD 279
Query: 373 -----VAGPRAPPRGPPRGPGEER--------------------------------AVAP 395
++ P P R P R
Sbjct: 280 THVQRLSPTMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLT 339
Query: 396 CPRACVCVPESRHSSCEGCGLQAVPRGF---------PSDTQLLDLRRNHFPSVPRAAFP 446
CP +CVC + SS G + R F P+ + L L N+ +V +
Sbjct: 340 CPSSCVCTSQ---SSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLL 396
Query: 447 GLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLER 506
L LHL + IA ++ GA L L LYL+ N L L + +G L YLYLE
Sbjct: 397 EYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEY 456
Query: 507 NRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALG 566
N ++ AL +L L L +N + L G T
Sbjct: 457 NVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGT---------------------- 494
Query: 567 PARELEKLHLDRNQLREVPT-GALEGLPALLELQLSGNP 604
L +L+L N +P G L+ LPA +++ L NP
Sbjct: 495 ---ALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENP 530
Score = 82.0 bits (201), Expect = 2e-15
Identities = 59/194 (30%), Positives = 93/194 (47%), Gaps = 7/194 (3%)
Query: 523 LFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLR 582
++ L L N + RL P + ++L N + E+ GA + L++LHL+ N+L
Sbjct: 64 IYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLE 123
Query: 583 EVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLG 642
+ GL +L LQ N + A+ GAF + + L+ L LN + L + F +
Sbjct: 124 ILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNK-LKVLILNDNLLLSLPSNVFRFV- 181
Query: 643 PGLQSLHLQKNQLRALP---ALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVG- 698
L L L+ N+L+ +P L + + I L NP++C C LLPL WL + + VG
Sbjct: 182 -LLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGE 240
Query: 699 ATCATPPNARGQRV 712
C TP G+ V
Sbjct: 241 IVCETPFRLHGKDV 254
Score = 80.5 bits (197), Expect = 5e-15
Identities = 65/191 (34%), Positives = 92/191 (48%), Gaps = 8/191 (4%)
Query: 33 CPQACICDNSRR----HVACRYQNLTEVPDAIPELT--QRLDLQGNLLKVIPAAAFQGVP 86
CP +C+C + +V C+ + T + D P+ T ++L L GN L+ +
Sbjct: 340 CPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYS 399
Query: 87 HLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNAL 146
L L L + + ++ EGAF L L L L N+L L DGL SL+ L LE N +
Sbjct: 400 SLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 459
Query: 147 EELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPE-ALAGL 205
+E++P TF AL L L L +N L LP F G R L L +N S L + L L
Sbjct: 460 KEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTR-LNLRNNHFSHLPVKGVLDQL 518
Query: 206 PALRRLSLHHN 216
PA ++ L N
Sbjct: 519 PAFIQIDLQEN 529
Score = 66.2 bits (160), Expect = 1e-10
Identities = 61/227 (26%), Positives = 95/227 (41%), Gaps = 30/227 (13%)
Query: 20 LLLAPARQAAAQRCPQACICDNSRR--HVACRYQNLTEVPDAIPELTQ--RLDLQGNLLK 75
+L +R+ A C C+C+ ++ C + T V P + +L L GNLL
Sbjct: 16 ILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLT 75
Query: 76 VIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGS 135
+ F + L L + ++ + GAF GL L L+L +N L L ++ GL S
Sbjct: 76 RLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLES 135
Query: 136 LRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALS 195
L L+ + N + + G F L L L L N L+ LP+ F R++ L+H
Sbjct: 136 LEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVF------RFVLLTH---- 185
Query: 196 VLAPEALAGLPALRRLSLHHNELQALP-GPVLSQARGLARLELGHNP 241
L L N L+ +P VL G+ ++L NP
Sbjct: 186 ---------------LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENP 217
Score = 65.9 bits (159), Expect = 1e-10
Identities = 63/230 (27%), Positives = 90/230 (39%), Gaps = 35/230 (15%)
Query: 502 LYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVS 561
LYL N V L SL LHL +N + + G +LR +YL+GN + +
Sbjct: 380 LYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLY 439
Query: 562 LGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQ 621
+ L+ L+L+ N ++E+ + L L L L+ N LR+L D F
Sbjct: 440 PSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFG------- 492
Query: 622 HLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLEL---IDLSSNPFH 678
G L L+L+ N LP L QL IDL NP+
Sbjct: 493 --------------------GTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWD 532
Query: 679 CDCQLLPLHRWLTGLNLRV---GATCATPPNARGQRVK--AAAAVFEDCP 723
C C ++ L W N V TC +P G+ +K A+ D P
Sbjct: 533 CTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICPDSP 582
Score = 62.0 bits (149), Expect = 2e-09
Identities = 62/222 (27%), Positives = 93/222 (41%), Gaps = 31/222 (13%)
Query: 135 SLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNAL 194
S ++L L GN L+ + +L L+L +N + + AF L +R L L+ N L
Sbjct: 376 SPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYL 435
Query: 195 SVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALP 254
VL P GL +L+ L L +N ++ + PLT+ AL
Sbjct: 436 EVLYPSMFDGLQSLQYLYLEYNVIKEI------------------KPLTFD------ALI 471
Query: 255 GLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLR---RLRLQGNP 311
L+ L L+ L++L F L L+LR N LP QL ++ LQ NP
Sbjct: 472 NLQLLFLNNNLLRSLPDNIFGGTA-LTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENP 530
Query: 312 LWCGCQARPLLEWLARAR---VRSDGACQGPRRLRGEALDAL 350
C C L +W A + ++ C+ P + GE L L
Sbjct: 531 WDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFL 572
>gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 125 bits (314), Expect = 1e-28
Identities = 135/519 (26%), Positives = 196/519 (37%), Gaps = 106/519 (20%)
Query: 138 RLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVL 197
+L L GN L L P F TL+L +N L + AF GL ++ L L++N L +L
Sbjct: 66 QLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEIL 125
Query: 198 APEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLR 257
+ GL +L L +N + A+ S+ L L+
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSK------------------------LNKLK 161
Query: 258 ELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP---PLQGPGQLRRLRLQGNPLWC 314
L+L+ L +L F H LDLRGN+L +P L+ G + ++L+ NP C
Sbjct: 162 VLILNDNLLLSLPSNVFRFVLLTH-LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNC 220
Query: 315 GCQARPLLEWLARARV-RSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERA- 372
C PL WL V + C+ P RL G+ + L DL CP +A + + A
Sbjct: 221 TCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDL-CPRKSASDSSQRGSHAD 279
Query: 373 -----VAGPRAPPRGPPRGPGEER--------------------------------AVAP 395
++ P P R P R
Sbjct: 280 THVQRLSPTMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLT 339
Query: 396 CPRACVCVPESRHSSCEGCGLQAVPRGF---------PSDTQLLDLRRNHFPSVPRAAFP 446
CP +CVC + SS G + R F P+ + L L N+ +V +
Sbjct: 340 CPSSCVCTSQ---SSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLL 396
Query: 447 GLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLER 506
L LHL + IA ++ GA L L LYL+ N L L + +G L YLYLE
Sbjct: 397 EYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEY 456
Query: 507 NRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALG 566
N ++ AL +L L L +N + L G T
Sbjct: 457 NVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGT---------------------- 494
Query: 567 PARELEKLHLDRNQLREVPT-GALEGLPALLELQLSGNP 604
L +L+L N +P G L+ LPA +++ L NP
Sbjct: 495 ---ALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENP 530
Score = 82.0 bits (201), Expect = 2e-15
Identities = 59/194 (30%), Positives = 93/194 (47%), Gaps = 7/194 (3%)
Query: 523 LFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLR 582
++ L L N + RL P + ++L N + E+ GA + L++LHL+ N+L
Sbjct: 64 IYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLE 123
Query: 583 EVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLG 642
+ GL +L LQ N + A+ GAF + + L+ L LN + L + F +
Sbjct: 124 ILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNK-LKVLILNDNLLLSLPSNVFRFV- 181
Query: 643 PGLQSLHLQKNQLRALP---ALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVG- 698
L L L+ N+L+ +P L + + I L NP++C C LLPL WL + + VG
Sbjct: 182 -LLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGE 240
Query: 699 ATCATPPNARGQRV 712
C TP G+ V
Sbjct: 241 IVCETPFRLHGKDV 254
Score = 80.5 bits (197), Expect = 5e-15
Identities = 65/191 (34%), Positives = 92/191 (48%), Gaps = 8/191 (4%)
Query: 33 CPQACICDNSRR----HVACRYQNLTEVPDAIPELT--QRLDLQGNLLKVIPAAAFQGVP 86
CP +C+C + +V C+ + T + D P+ T ++L L GN L+ +
Sbjct: 340 CPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYS 399
Query: 87 HLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNAL 146
L L L + + ++ EGAF L L L L N+L L DGL SL+ L LE N +
Sbjct: 400 SLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 459
Query: 147 EELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPE-ALAGL 205
+E++P TF AL L L L +N L LP F G R L L +N S L + L L
Sbjct: 460 KEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTR-LNLRNNHFSHLPVKGVLDQL 518
Query: 206 PALRRLSLHHN 216
PA ++ L N
Sbjct: 519 PAFIQIDLQEN 529
Score = 66.2 bits (160), Expect = 1e-10
Identities = 61/227 (26%), Positives = 95/227 (41%), Gaps = 30/227 (13%)
Query: 20 LLLAPARQAAAQRCPQACICDNSRR--HVACRYQNLTEVPDAIPELTQ--RLDLQGNLLK 75
+L +R+ A C C+C+ ++ C + T V P + +L L GNLL
Sbjct: 16 ILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLT 75
Query: 76 VIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGS 135
+ F + L L + ++ + GAF GL L L+L +N L L ++ GL S
Sbjct: 76 RLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLES 135
Query: 136 LRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALS 195
L L+ + N + + G F L L L L N L+ LP+ F R++ L+H
Sbjct: 136 LEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVF------RFVLLTH---- 185
Query: 196 VLAPEALAGLPALRRLSLHHNELQALP-GPVLSQARGLARLELGHNP 241
L L N L+ +P VL G+ ++L NP
Sbjct: 186 ---------------LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENP 217
Score = 65.9 bits (159), Expect = 1e-10
Identities = 63/230 (27%), Positives = 90/230 (39%), Gaps = 35/230 (15%)
Query: 502 LYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVS 561
LYL N V L SL LHL +N + + G +LR +YL+GN + +
Sbjct: 380 LYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLY 439
Query: 562 LGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQ 621
+ L+ L+L+ N ++E+ + L L L L+ N LR+L D F
Sbjct: 440 PSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFG------- 492
Query: 622 HLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLEL---IDLSSNPFH 678
G L L+L+ N LP L QL IDL NP+
Sbjct: 493 --------------------GTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWD 532
Query: 679 CDCQLLPLHRWLTGLNLRV---GATCATPPNARGQRVK--AAAAVFEDCP 723
C C ++ L W N V TC +P G+ +K A+ D P
Sbjct: 533 CTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICPDSP 582
Score = 62.0 bits (149), Expect = 2e-09
Identities = 62/222 (27%), Positives = 93/222 (41%), Gaps = 31/222 (13%)
Query: 135 SLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNAL 194
S ++L L GN L+ + +L L+L +N + + AF L +R L L+ N L
Sbjct: 376 SPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYL 435
Query: 195 SVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALP 254
VL P GL +L+ L L +N ++ + PLT+ AL
Sbjct: 436 EVLYPSMFDGLQSLQYLYLEYNVIKEI------------------KPLTFD------ALI 471
Query: 255 GLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLR---RLRLQGNP 311
L+ L L+ L++L F L L+LR N LP QL ++ LQ NP
Sbjct: 472 NLQLLFLNNNLLRSLPDNIFGGTA-LTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENP 530
Query: 312 LWCGCQARPLLEWLARAR---VRSDGACQGPRRLRGEALDAL 350
C C L +W A + ++ C+ P + GE L L
Sbjct: 531 WDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFL 572
>gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 125 bits (314), Expect = 1e-28
Identities = 135/519 (26%), Positives = 196/519 (37%), Gaps = 106/519 (20%)
Query: 138 RLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVL 197
+L L GN L L P F TL+L +N L + AF GL ++ L L++N L +L
Sbjct: 66 QLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEIL 125
Query: 198 APEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLR 257
+ GL +L L +N + A+ S+ L L+
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSK------------------------LNKLK 161
Query: 258 ELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP---PLQGPGQLRRLRLQGNPLWC 314
L+L+ L +L F H LDLRGN+L +P L+ G + ++L+ NP C
Sbjct: 162 VLILNDNLLLSLPSNVFRFVLLTH-LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNC 220
Query: 315 GCQARPLLEWLARARV-RSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERA- 372
C PL WL V + C+ P RL G+ + L DL CP +A + + A
Sbjct: 221 TCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDL-CPRKSASDSSQRGSHAD 279
Query: 373 -----VAGPRAPPRGPPRGPGEER--------------------------------AVAP 395
++ P P R P R
Sbjct: 280 THVQRLSPTMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLT 339
Query: 396 CPRACVCVPESRHSSCEGCGLQAVPRGF---------PSDTQLLDLRRNHFPSVPRAAFP 446
CP +CVC + SS G + R F P+ + L L N+ +V +
Sbjct: 340 CPSSCVCTSQ---SSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLL 396
Query: 447 GLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLER 506
L LHL + IA ++ GA L L LYL+ N L L + +G L YLYLE
Sbjct: 397 EYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEY 456
Query: 507 NRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALG 566
N ++ AL +L L L +N + L G T
Sbjct: 457 NVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGT---------------------- 494
Query: 567 PARELEKLHLDRNQLREVPT-GALEGLPALLELQLSGNP 604
L +L+L N +P G L+ LPA +++ L NP
Sbjct: 495 ---ALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENP 530
Score = 82.0 bits (201), Expect = 2e-15
Identities = 59/194 (30%), Positives = 93/194 (47%), Gaps = 7/194 (3%)
Query: 523 LFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLR 582
++ L L N + RL P + ++L N + E+ GA + L++LHL+ N+L
Sbjct: 64 IYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLE 123
Query: 583 EVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLG 642
+ GL +L LQ N + A+ GAF + + L+ L LN + L + F +
Sbjct: 124 ILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNK-LKVLILNDNLLLSLPSNVFRFV- 181
Query: 643 PGLQSLHLQKNQLRALP---ALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVG- 698
L L L+ N+L+ +P L + + I L NP++C C LLPL WL + + VG
Sbjct: 182 -LLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGE 240
Query: 699 ATCATPPNARGQRV 712
C TP G+ V
Sbjct: 241 IVCETPFRLHGKDV 254
Score = 80.5 bits (197), Expect = 5e-15
Identities = 65/191 (34%), Positives = 92/191 (48%), Gaps = 8/191 (4%)
Query: 33 CPQACICDNSRR----HVACRYQNLTEVPDAIPELT--QRLDLQGNLLKVIPAAAFQGVP 86
CP +C+C + +V C+ + T + D P+ T ++L L GN L+ +
Sbjct: 340 CPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYS 399
Query: 87 HLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNAL 146
L L L + + ++ EGAF L L L L N+L L DGL SL+ L LE N +
Sbjct: 400 SLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 459
Query: 147 EELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPE-ALAGL 205
+E++P TF AL L L L +N L LP F G R L L +N S L + L L
Sbjct: 460 KEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTR-LNLRNNHFSHLPVKGVLDQL 518
Query: 206 PALRRLSLHHN 216
PA ++ L N
Sbjct: 519 PAFIQIDLQEN 529
Score = 66.2 bits (160), Expect = 1e-10
Identities = 61/227 (26%), Positives = 95/227 (41%), Gaps = 30/227 (13%)
Query: 20 LLLAPARQAAAQRCPQACICDNSRR--HVACRYQNLTEVPDAIPELTQ--RLDLQGNLLK 75
+L +R+ A C C+C+ ++ C + T V P + +L L GNLL
Sbjct: 16 ILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLT 75
Query: 76 VIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGS 135
+ F + L L + ++ + GAF GL L L+L +N L L ++ GL S
Sbjct: 76 RLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLES 135
Query: 136 LRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALS 195
L L+ + N + + G F L L L L N L+ LP+ F R++ L+H
Sbjct: 136 LEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVF------RFVLLTH---- 185
Query: 196 VLAPEALAGLPALRRLSLHHNELQALP-GPVLSQARGLARLELGHNP 241
L L N L+ +P VL G+ ++L NP
Sbjct: 186 ---------------LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENP 217
Score = 65.9 bits (159), Expect = 1e-10
Identities = 63/230 (27%), Positives = 90/230 (39%), Gaps = 35/230 (15%)
Query: 502 LYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVS 561
LYL N V L SL LHL +N + + G +LR +YL+GN + +
Sbjct: 380 LYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLY 439
Query: 562 LGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQ 621
+ L+ L+L+ N ++E+ + L L L L+ N LR+L D F
Sbjct: 440 PSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFG------- 492
Query: 622 HLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLEL---IDLSSNPFH 678
G L L+L+ N LP L QL IDL NP+
Sbjct: 493 --------------------GTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWD 532
Query: 679 CDCQLLPLHRWLTGLNLRV---GATCATPPNARGQRVK--AAAAVFEDCP 723
C C ++ L W N V TC +P G+ +K A+ D P
Sbjct: 533 CTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICPDSP 582
Score = 62.0 bits (149), Expect = 2e-09
Identities = 62/222 (27%), Positives = 93/222 (41%), Gaps = 31/222 (13%)
Query: 135 SLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNAL 194
S ++L L GN L+ + +L L+L +N + + AF L +R L L+ N L
Sbjct: 376 SPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYL 435
Query: 195 SVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALP 254
VL P GL +L+ L L +N ++ + PLT+ AL
Sbjct: 436 EVLYPSMFDGLQSLQYLYLEYNVIKEI------------------KPLTFD------ALI 471
Query: 255 GLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLR---RLRLQGNP 311
L+ L L+ L++L F L L+LR N LP QL ++ LQ NP
Sbjct: 472 NLQLLFLNNNLLRSLPDNIFGGTA-LTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENP 530
Query: 312 LWCGCQARPLLEWLARAR---VRSDGACQGPRRLRGEALDAL 350
C C L +W A + ++ C+ P + GE L L
Sbjct: 531 WDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFL 572
>gi|221136969 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 125 bits (314), Expect = 1e-28
Identities = 135/519 (26%), Positives = 196/519 (37%), Gaps = 106/519 (20%)
Query: 138 RLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVL 197
+L L GN L L P F TL+L +N L + AF GL ++ L L++N L +L
Sbjct: 66 QLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEIL 125
Query: 198 APEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLR 257
+ GL +L L +N + A+ S+ L L+
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSK------------------------LNKLK 161
Query: 258 ELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP---PLQGPGQLRRLRLQGNPLWC 314
L+L+ L +L F H LDLRGN+L +P L+ G + ++L+ NP C
Sbjct: 162 VLILNDNLLLSLPSNVFRFVLLTH-LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNC 220
Query: 315 GCQARPLLEWLARARV-RSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERA- 372
C PL WL V + C+ P RL G+ + L DL CP +A + + A
Sbjct: 221 TCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDL-CPRKSASDSSQRGSHAD 279
Query: 373 -----VAGPRAPPRGPPRGPGEER--------------------------------AVAP 395
++ P P R P R
Sbjct: 280 THVQRLSPTMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLT 339
Query: 396 CPRACVCVPESRHSSCEGCGLQAVPRGF---------PSDTQLLDLRRNHFPSVPRAAFP 446
CP +CVC + SS G + R F P+ + L L N+ +V +
Sbjct: 340 CPSSCVCTSQ---SSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLL 396
Query: 447 GLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLER 506
L LHL + IA ++ GA L L LYL+ N L L + +G L YLYLE
Sbjct: 397 EYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEY 456
Query: 507 NRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALG 566
N ++ AL +L L L +N + L G T
Sbjct: 457 NVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGT---------------------- 494
Query: 567 PARELEKLHLDRNQLREVPT-GALEGLPALLELQLSGNP 604
L +L+L N +P G L+ LPA +++ L NP
Sbjct: 495 ---ALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENP 530
Score = 82.0 bits (201), Expect = 2e-15
Identities = 59/194 (30%), Positives = 93/194 (47%), Gaps = 7/194 (3%)
Query: 523 LFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLR 582
++ L L N + RL P + ++L N + E+ GA + L++LHL+ N+L
Sbjct: 64 IYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLE 123
Query: 583 EVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLG 642
+ GL +L LQ N + A+ GAF + + L+ L LN + L + F +
Sbjct: 124 ILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNK-LKVLILNDNLLLSLPSNVFRFV- 181
Query: 643 PGLQSLHLQKNQLRALP---ALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVG- 698
L L L+ N+L+ +P L + + I L NP++C C LLPL WL + + VG
Sbjct: 182 -LLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGE 240
Query: 699 ATCATPPNARGQRV 712
C TP G+ V
Sbjct: 241 IVCETPFRLHGKDV 254
Score = 80.5 bits (197), Expect = 5e-15
Identities = 65/191 (34%), Positives = 92/191 (48%), Gaps = 8/191 (4%)
Query: 33 CPQACICDNSRR----HVACRYQNLTEVPDAIPELT--QRLDLQGNLLKVIPAAAFQGVP 86
CP +C+C + +V C+ + T + D P+ T ++L L GN L+ +
Sbjct: 340 CPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYS 399
Query: 87 HLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNAL 146
L L L + + ++ EGAF L L L L N+L L DGL SL+ L LE N +
Sbjct: 400 SLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 459
Query: 147 EELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPE-ALAGL 205
+E++P TF AL L L L +N L LP F G R L L +N S L + L L
Sbjct: 460 KEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTR-LNLRNNHFSHLPVKGVLDQL 518
Query: 206 PALRRLSLHHN 216
PA ++ L N
Sbjct: 519 PAFIQIDLQEN 529
Score = 66.2 bits (160), Expect = 1e-10
Identities = 61/227 (26%), Positives = 95/227 (41%), Gaps = 30/227 (13%)
Query: 20 LLLAPARQAAAQRCPQACICDNSRR--HVACRYQNLTEVPDAIPELTQ--RLDLQGNLLK 75
+L +R+ A C C+C+ ++ C + T V P + +L L GNLL
Sbjct: 16 ILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLT 75
Query: 76 VIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGS 135
+ F + L L + ++ + GAF GL L L+L +N L L ++ GL S
Sbjct: 76 RLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLES 135
Query: 136 LRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALS 195
L L+ + N + + G F L L L L N L+ LP+ F R++ L+H
Sbjct: 136 LEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVF------RFVLLTH---- 185
Query: 196 VLAPEALAGLPALRRLSLHHNELQALP-GPVLSQARGLARLELGHNP 241
L L N L+ +P VL G+ ++L NP
Sbjct: 186 ---------------LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENP 217
Score = 65.9 bits (159), Expect = 1e-10
Identities = 63/230 (27%), Positives = 90/230 (39%), Gaps = 35/230 (15%)
Query: 502 LYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVS 561
LYL N V L SL LHL +N + + G +LR +YL+GN + +
Sbjct: 380 LYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLY 439
Query: 562 LGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQ 621
+ L+ L+L+ N ++E+ + L L L L+ N LR+L D F
Sbjct: 440 PSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFG------- 492
Query: 622 HLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLEL---IDLSSNPFH 678
G L L+L+ N LP L QL IDL NP+
Sbjct: 493 --------------------GTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWD 532
Query: 679 CDCQLLPLHRWLTGLNLRV---GATCATPPNARGQRVK--AAAAVFEDCP 723
C C ++ L W N V TC +P G+ +K A+ D P
Sbjct: 533 CTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICPDSP 582
Score = 62.0 bits (149), Expect = 2e-09
Identities = 62/222 (27%), Positives = 93/222 (41%), Gaps = 31/222 (13%)
Query: 135 SLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNAL 194
S ++L L GN L+ + +L L+L +N + + AF L +R L L+ N L
Sbjct: 376 SPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYL 435
Query: 195 SVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALP 254
VL P GL +L+ L L +N ++ + PLT+ AL
Sbjct: 436 EVLYPSMFDGLQSLQYLYLEYNVIKEI------------------KPLTFD------ALI 471
Query: 255 GLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLR---RLRLQGNP 311
L+ L L+ L++L F L L+LR N LP QL ++ LQ NP
Sbjct: 472 NLQLLFLNNNLLRSLPDNIFGGTA-LTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENP 530
Query: 312 LWCGCQARPLLEWLARAR---VRSDGACQGPRRLRGEALDAL 350
C C L +W A + ++ C+ P + GE L L
Sbjct: 531 WDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFL 572
>gi|221136965 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 125 bits (314), Expect = 1e-28
Identities = 135/519 (26%), Positives = 196/519 (37%), Gaps = 106/519 (20%)
Query: 138 RLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVL 197
+L L GN L L P F TL+L +N L + AF GL ++ L L++N L +L
Sbjct: 66 QLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEIL 125
Query: 198 APEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLR 257
+ GL +L L +N + A+ S+ L L+
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSK------------------------LNKLK 161
Query: 258 ELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP---PLQGPGQLRRLRLQGNPLWC 314
L+L+ L +L F H LDLRGN+L +P L+ G + ++L+ NP C
Sbjct: 162 VLILNDNLLLSLPSNVFRFVLLTH-LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNC 220
Query: 315 GCQARPLLEWLARARV-RSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERA- 372
C PL WL V + C+ P RL G+ + L DL CP +A + + A
Sbjct: 221 TCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDL-CPRKSASDSSQRGSHAD 279
Query: 373 -----VAGPRAPPRGPPRGPGEER--------------------------------AVAP 395
++ P P R P R
Sbjct: 280 THVQRLSPTMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLT 339
Query: 396 CPRACVCVPESRHSSCEGCGLQAVPRGF---------PSDTQLLDLRRNHFPSVPRAAFP 446
CP +CVC + SS G + R F P+ + L L N+ +V +
Sbjct: 340 CPSSCVCTSQ---SSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLL 396
Query: 447 GLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLER 506
L LHL + IA ++ GA L L LYL+ N L L + +G L YLYLE
Sbjct: 397 EYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEY 456
Query: 507 NRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALG 566
N ++ AL +L L L +N + L G T
Sbjct: 457 NVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGT---------------------- 494
Query: 567 PARELEKLHLDRNQLREVPT-GALEGLPALLELQLSGNP 604
L +L+L N +P G L+ LPA +++ L NP
Sbjct: 495 ---ALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENP 530
Score = 82.0 bits (201), Expect = 2e-15
Identities = 59/194 (30%), Positives = 93/194 (47%), Gaps = 7/194 (3%)
Query: 523 LFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLR 582
++ L L N + RL P + ++L N + E+ GA + L++LHL+ N+L
Sbjct: 64 IYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLE 123
Query: 583 EVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLG 642
+ GL +L LQ N + A+ GAF + + L+ L LN + L + F +
Sbjct: 124 ILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNK-LKVLILNDNLLLSLPSNVFRFV- 181
Query: 643 PGLQSLHLQKNQLRALP---ALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVG- 698
L L L+ N+L+ +P L + + I L NP++C C LLPL WL + + VG
Sbjct: 182 -LLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGE 240
Query: 699 ATCATPPNARGQRV 712
C TP G+ V
Sbjct: 241 IVCETPFRLHGKDV 254
Score = 80.5 bits (197), Expect = 5e-15
Identities = 65/191 (34%), Positives = 92/191 (48%), Gaps = 8/191 (4%)
Query: 33 CPQACICDNSRR----HVACRYQNLTEVPDAIPELT--QRLDLQGNLLKVIPAAAFQGVP 86
CP +C+C + +V C+ + T + D P+ T ++L L GN L+ +
Sbjct: 340 CPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYS 399
Query: 87 HLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNAL 146
L L L + + ++ EGAF L L L L N+L L DGL SL+ L LE N +
Sbjct: 400 SLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 459
Query: 147 EELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPE-ALAGL 205
+E++P TF AL L L L +N L LP F G R L L +N S L + L L
Sbjct: 460 KEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTR-LNLRNNHFSHLPVKGVLDQL 518
Query: 206 PALRRLSLHHN 216
PA ++ L N
Sbjct: 519 PAFIQIDLQEN 529
Score = 66.2 bits (160), Expect = 1e-10
Identities = 61/227 (26%), Positives = 95/227 (41%), Gaps = 30/227 (13%)
Query: 20 LLLAPARQAAAQRCPQACICDNSRR--HVACRYQNLTEVPDAIPELTQ--RLDLQGNLLK 75
+L +R+ A C C+C+ ++ C + T V P + +L L GNLL
Sbjct: 16 ILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLT 75
Query: 76 VIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGS 135
+ F + L L + ++ + GAF GL L L+L +N L L ++ GL S
Sbjct: 76 RLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLES 135
Query: 136 LRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALS 195
L L+ + N + + G F L L L L N L+ LP+ F R++ L+H
Sbjct: 136 LEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVF------RFVLLTH---- 185
Query: 196 VLAPEALAGLPALRRLSLHHNELQALP-GPVLSQARGLARLELGHNP 241
L L N L+ +P VL G+ ++L NP
Sbjct: 186 ---------------LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENP 217
Score = 65.9 bits (159), Expect = 1e-10
Identities = 63/230 (27%), Positives = 90/230 (39%), Gaps = 35/230 (15%)
Query: 502 LYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVS 561
LYL N V L SL LHL +N + + G +LR +YL+GN + +
Sbjct: 380 LYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLY 439
Query: 562 LGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQ 621
+ L+ L+L+ N ++E+ + L L L L+ N LR+L D F
Sbjct: 440 PSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFG------- 492
Query: 622 HLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLEL---IDLSSNPFH 678
G L L+L+ N LP L QL IDL NP+
Sbjct: 493 --------------------GTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWD 532
Query: 679 CDCQLLPLHRWLTGLNLRV---GATCATPPNARGQRVK--AAAAVFEDCP 723
C C ++ L W N V TC +P G+ +K A+ D P
Sbjct: 533 CTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICPDSP 582
Score = 62.0 bits (149), Expect = 2e-09
Identities = 62/222 (27%), Positives = 93/222 (41%), Gaps = 31/222 (13%)
Query: 135 SLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNAL 194
S ++L L GN L+ + +L L+L +N + + AF L +R L L+ N L
Sbjct: 376 SPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYL 435
Query: 195 SVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALP 254
VL P GL +L+ L L +N ++ + PLT+ AL
Sbjct: 436 EVLYPSMFDGLQSLQYLYLEYNVIKEI------------------KPLTFD------ALI 471
Query: 255 GLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLR---RLRLQGNP 311
L+ L L+ L++L F L L+LR N LP QL ++ LQ NP
Sbjct: 472 NLQLLFLNNNLLRSLPDNIFGGTA-LTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENP 530
Query: 312 LWCGCQARPLLEWLARAR---VRSDGACQGPRRLRGEALDAL 350
C C L +W A + ++ C+ P + GE L L
Sbjct: 531 WDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFL 572
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,931,123
Number of Sequences: 37866
Number of extensions: 1812481
Number of successful extensions: 11951
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 211
Number of HSP's successfully gapped in prelim test: 140
Number of HSP's that attempted gapping in prelim test: 6538
Number of HSP's gapped (non-prelim): 1997
length of query: 762
length of database: 18,247,518
effective HSP length: 110
effective length of query: 652
effective length of database: 14,082,258
effective search space: 9181632216
effective search space used: 9181632216
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.