Guide to the Human Genome
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Search of human proteins with 194440709

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens]
         (508 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens]      1044   0.0  
gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens]      1044   0.0  
gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens]       1044   0.0  
gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens]       995   0.0  
gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens]       814   0.0  
gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens]       798   0.0  
gi|4507903 vaccinia related kinase 1 [Homo sapiens]                   347   2e-95
gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens]        192   5e-49
gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens]        192   5e-49
gi|23199991 casein kinase 1 epsilon [Homo sapiens]                    123   5e-28
gi|4503093 casein kinase 1 epsilon [Homo sapiens]                     123   5e-28
gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens]           122   8e-28
gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens]           122   8e-28
gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens]         113   5e-25
gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens]        108   1e-23
gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens]         108   1e-23
gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens]              106   6e-23
gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens]         104   2e-22
gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens]        103   4e-22
gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens]         103   4e-22
gi|58761548 tau tubulin kinase 1 [Homo sapiens]                       100   2e-21
gi|153791733 casein kinase 1, gamma 2 [Homo sapiens]                  100   4e-21
gi|98986450 casein kinase 1, gamma 1 [Homo sapiens]                    97   3e-20
gi|116812624 tau tubulin kinase 2 [Homo sapiens]                       96   8e-20
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H...    68   2e-11
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso...    59   1e-08
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso...    59   1e-08
gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Ho...    56   9e-08
gi|83627721 NIMA-related kinase 5 [Homo sapiens]                       56   9e-08
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]           53   6e-07

>gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens]
          Length = 508

 Score = 1044 bits (2700), Expect = 0.0
 Identities = 508/508 (100%), Positives = 508/508 (100%)

Query: 1   MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV 60
           MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV
Sbjct: 1   MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV 60

Query: 61  KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV 120
           KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV
Sbjct: 61  KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV 120

Query: 121 MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD 180
           MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD
Sbjct: 121 MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD 180

Query: 181 QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM 240
           QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM
Sbjct: 181 QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM 240

Query: 241 LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY 300
           LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY
Sbjct: 241 LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY 300

Query: 301 DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI 360
           DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI
Sbjct: 301 DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI 360

Query: 361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI 420
           EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI
Sbjct: 361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI 420

Query: 421 SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS 480
           SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS
Sbjct: 421 SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS 480

Query: 481 EETNADVYYYRIIIPVLLMLVFLALFFL 508
           EETNADVYYYRIIIPVLLMLVFLALFFL
Sbjct: 481 EETNADVYYYRIIIPVLLMLVFLALFFL 508


>gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens]
          Length = 508

 Score = 1044 bits (2700), Expect = 0.0
 Identities = 508/508 (100%), Positives = 508/508 (100%)

Query: 1   MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV 60
           MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV
Sbjct: 1   MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV 60

Query: 61  KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV 120
           KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV
Sbjct: 61  KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV 120

Query: 121 MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD 180
           MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD
Sbjct: 121 MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD 180

Query: 181 QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM 240
           QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM
Sbjct: 181 QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM 240

Query: 241 LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY 300
           LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY
Sbjct: 241 LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY 300

Query: 301 DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI 360
           DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI
Sbjct: 301 DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI 360

Query: 361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI 420
           EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI
Sbjct: 361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI 420

Query: 421 SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS 480
           SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS
Sbjct: 421 SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS 480

Query: 481 EETNADVYYYRIIIPVLLMLVFLALFFL 508
           EETNADVYYYRIIIPVLLMLVFLALFFL
Sbjct: 481 EETNADVYYYRIIIPVLLMLVFLALFFL 508


>gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens]
          Length = 508

 Score = 1044 bits (2700), Expect = 0.0
 Identities = 508/508 (100%), Positives = 508/508 (100%)

Query: 1   MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV 60
           MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV
Sbjct: 1   MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV 60

Query: 61  KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV 120
           KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV
Sbjct: 61  KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV 120

Query: 121 MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD 180
           MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD
Sbjct: 121 MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD 180

Query: 181 QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM 240
           QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM
Sbjct: 181 QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM 240

Query: 241 LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY 300
           LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY
Sbjct: 241 LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY 300

Query: 301 DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI 360
           DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI
Sbjct: 301 DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI 360

Query: 361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI 420
           EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI
Sbjct: 361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI 420

Query: 421 SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS 480
           SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS
Sbjct: 421 SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS 480

Query: 481 EETNADVYYYRIIIPVLLMLVFLALFFL 508
           EETNADVYYYRIIIPVLLMLVFLALFFL
Sbjct: 481 EETNADVYYYRIIIPVLLMLVFLALFFL 508


>gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens]
          Length = 485

 Score =  995 bits (2572), Expect = 0.0
 Identities = 485/485 (100%), Positives = 485/485 (100%)

Query: 24  MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKK 83
           MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKK
Sbjct: 1   MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKK 60

Query: 84  DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTV 143
           DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTV
Sbjct: 61  DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTV 120

Query: 144 LQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQ 203
           LQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQ
Sbjct: 121 LQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQ 180

Query: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 263
           ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA
Sbjct: 181 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 240

Query: 264 KTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPL 323
           KTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPL
Sbjct: 241 KTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPL 300

Query: 324 DFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEK 383
           DFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEK
Sbjct: 301 DFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEK 360

Query: 384 LIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFK 443
           LIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFK
Sbjct: 361 LIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFK 420

Query: 444 KSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLSEETNADVYYYRIIIPVLLMLVFL 503
           KSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLSEETNADVYYYRIIIPVLLMLVFL
Sbjct: 421 KSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLSEETNADVYYYRIIIPVLLMLVFL 480

Query: 504 ALFFL 508
           ALFFL
Sbjct: 481 ALFFL 485


>gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens]
          Length = 396

 Score =  814 bits (2103), Expect = 0.0
 Identities = 394/394 (100%), Positives = 394/394 (100%)

Query: 1   MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV 60
           MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV
Sbjct: 1   MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV 60

Query: 61  KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV 120
           KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV
Sbjct: 61  KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV 120

Query: 121 MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD 180
           MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD
Sbjct: 121 MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD 180

Query: 181 QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM 240
           QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM
Sbjct: 181 QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM 240

Query: 241 LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY 300
           LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY
Sbjct: 241 LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY 300

Query: 301 DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI 360
           DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI
Sbjct: 301 DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI 360

Query: 361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQ 394
           EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQ
Sbjct: 361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQ 394


>gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens]
          Length = 390

 Score =  798 bits (2060), Expect = 0.0
 Identities = 390/390 (100%), Positives = 390/390 (100%)

Query: 119 MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 178
           MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN
Sbjct: 1   MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 60

Query: 179 PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 238
           PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY
Sbjct: 61  PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 120

Query: 239 CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL 298
           CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL
Sbjct: 121 CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL 180

Query: 299 AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR 358
           AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR
Sbjct: 181 AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR 240

Query: 359 LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ 418
           LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ
Sbjct: 241 LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ 300

Query: 419 KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT 478
           KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT
Sbjct: 301 KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT 360

Query: 479 LSEETNADVYYYRIIIPVLLMLVFLALFFL 508
           LSEETNADVYYYRIIIPVLLMLVFLALFFL
Sbjct: 361 LSEETNADVYYYRIIIPVLLMLVFLALFFL 390


>gi|4507903 vaccinia related kinase 1 [Homo sapiens]
          Length = 396

 Score =  347 bits (889), Expect = 2e-95
 Identities = 190/401 (47%), Positives = 248/401 (61%), Gaps = 23/401 (5%)

Query: 8   KYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPE--KDARHVVKVEYQ 65
           K  L   F  G+++ DM   +W +G  IG GGFG IYLA   +      DA  VVKVE  
Sbjct: 16  KRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPS 75

Query: 66  ENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLG 125
           +NGPLF+ELKFYQR AK + I+KWI  ++L YLG+P ++GSGL +  G+SYRFM+M+R G
Sbjct: 76  DNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG 135

Query: 126 IDLQKISGQNGT-FKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYL 184
            DLQKI   N   F + TVLQL +R+LD+LEYIHE+EYVHGDIKA+NLLL YKNPDQVYL
Sbjct: 136 SDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYL 195

Query: 185 ADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWL 244
            DYGL+YRYCP G HK+Y+E+P++ H+GTIEFTS+DAH GVA SRR D+EILGYCM++WL
Sbjct: 196 VDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWL 255

Query: 245 CGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKP 304
            G LPWE NLKDP  V+ +K    + +   + K  P  +   EIA+++     L Y EKP
Sbjct: 256 TGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKP 315

Query: 305 NYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKV 364
            Y+ L+ IL      +G  D      S+         V++     K + K   + IE+  
Sbjct: 316 LYENLRDILLQGLKAIGSKDDGKLDLSV---------VENGGLKAKTITKKRKKEIEES- 365

Query: 365 HSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQE 405
             E   E       Q E         EA Q  +R R++ Q+
Sbjct: 366 -KEPGVEDTEWSNTQTE---------EAIQTRSRTRKRVQK 396


>gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens]
          Length = 424

 Score =  192 bits (489), Expect = 5e-49
 Identities = 118/327 (36%), Positives = 169/327 (51%), Gaps = 25/327 (7%)

Query: 16  PEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNK------PEKDARHVVKVEYQENGP 69
           P G VL D  G QW L         G++Y A PT+       P+K  +  +K++ ++ G 
Sbjct: 103 PTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQ-KFSLKLDAKD-GR 160

Query: 70  LFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQ 129
           LF+E  F+QR AK   + KW +      L IP   G G+ + K   YRF+V+  LG  LQ
Sbjct: 161 LFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRSLQ 217

Query: 130 KIS--GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADY 187
                       + +VLQ+  R+LD LE++HENEYVHG++ A N+ +  ++  QV LA Y
Sbjct: 218 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 277

Query: 188 GLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGK 247
           G ++RYCP+G H  Y E  R  H G +EF S+D HKG   SRRSD++ LGYCML+WL G 
Sbjct: 278 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGF 337

Query: 248 LPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQ 307
           LPW   L +   +   K   +D+    V            + ++L    +L Y+EKP Y 
Sbjct: 338 LPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYA 397

Query: 308 ALKKIL------------NPHGIPLGP 322
            L+  L            +P G+P+ P
Sbjct: 398 MLRNNLEALLQDLRVSPYDPIGLPMVP 424


>gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens]
          Length = 474

 Score =  192 bits (489), Expect = 5e-49
 Identities = 118/327 (36%), Positives = 169/327 (51%), Gaps = 25/327 (7%)

Query: 16  PEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNK------PEKDARHVVKVEYQENGP 69
           P G VL D  G QW L         G++Y A PT+       P+K  +  +K++ ++ G 
Sbjct: 153 PTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQ-KFSLKLDAKD-GR 210

Query: 70  LFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQ 129
           LF+E  F+QR AK   + KW +      L IP   G G+ + K   YRF+V+  LG  LQ
Sbjct: 211 LFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRSLQ 267

Query: 130 KIS--GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADY 187
                       + +VLQ+  R+LD LE++HENEYVHG++ A N+ +  ++  QV LA Y
Sbjct: 268 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 327

Query: 188 GLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGK 247
           G ++RYCP+G H  Y E  R  H G +EF S+D HKG   SRRSD++ LGYCML+WL G 
Sbjct: 328 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGF 387

Query: 248 LPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQ 307
           LPW   L +   +   K   +D+    V            + ++L    +L Y+EKP Y 
Sbjct: 388 LPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYA 447

Query: 308 ALKKIL------------NPHGIPLGP 322
            L+  L            +P G+P+ P
Sbjct: 448 MLRNNLEALLQDLRVSPYDPIGLPMVP 474


>gi|23199991 casein kinase 1 epsilon [Homo sapiens]
          Length = 416

 Score =  123 bits (308), Expect = 5e-28
 Identities = 95/294 (32%), Positives = 141/294 (47%), Gaps = 34/294 (11%)

Query: 26  GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDC 85
           GN++ LG+KIGSG FG IYL       E+ A  +  V+  ++  L  E KFY+ +     
Sbjct: 6   GNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVK-TKHPQLHIESKFYKMMQGG-- 62

Query: 86  IKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKSTVL 144
                       +GIP     G        Y  MVME LG  L+ +    +  F   TVL
Sbjct: 63  ------------VGIPSIKWCGAEG----DYNVMVMELLGPSLEDLFNFCSRKFSLKTVL 106

Query: 145 QLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQYQ 203
            L  +M+  +EYIH   ++H D+K  N L+G  K  + VY+ D+GL+ +Y     H+   
Sbjct: 107 LLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIP 166

Query: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 263
               K   GT  + S++ H G+  SRR D+E LGY ++ +  G LPW Q LK   A +  
Sbjct: 167 YRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW-QGLK--AATKRQ 223

Query: 264 KTNLLDELPQS-----VLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
           K   + E   S     + K  PS     E + +L    SL +D+KP+Y  L+++
Sbjct: 224 KYERISEKKMSTPIEVLCKGYPS-----EFSTYLNFCRSLRFDDKPDYSYLRQL 272


>gi|4503093 casein kinase 1 epsilon [Homo sapiens]
          Length = 416

 Score =  123 bits (308), Expect = 5e-28
 Identities = 95/294 (32%), Positives = 141/294 (47%), Gaps = 34/294 (11%)

Query: 26  GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDC 85
           GN++ LG+KIGSG FG IYL       E+ A  +  V+  ++  L  E KFY+ +     
Sbjct: 6   GNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVK-TKHPQLHIESKFYKMMQGG-- 62

Query: 86  IKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKSTVL 144
                       +GIP     G        Y  MVME LG  L+ +    +  F   TVL
Sbjct: 63  ------------VGIPSIKWCGAEG----DYNVMVMELLGPSLEDLFNFCSRKFSLKTVL 106

Query: 145 QLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQYQ 203
            L  +M+  +EYIH   ++H D+K  N L+G  K  + VY+ D+GL+ +Y     H+   
Sbjct: 107 LLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIP 166

Query: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 263
               K   GT  + S++ H G+  SRR D+E LGY ++ +  G LPW Q LK   A +  
Sbjct: 167 YRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW-QGLK--AATKRQ 223

Query: 264 KTNLLDELPQS-----VLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
           K   + E   S     + K  PS     E + +L    SL +D+KP+Y  L+++
Sbjct: 224 KYERISEKKMSTPIEVLCKGYPS-----EFSTYLNFCRSLRFDDKPDYSYLRQL 272


>gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens]
          Length = 409

 Score =  122 bits (306), Expect = 8e-28
 Identities = 95/294 (32%), Positives = 140/294 (47%), Gaps = 34/294 (11%)

Query: 26  GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDC 85
           GN++ LG+KIGSG FG IYL       E+ A  +  V+  ++  L  E K Y+ +     
Sbjct: 6   GNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVK-TKHPQLHIESKIYKMMQGG-- 62

Query: 86  IKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKSTVL 144
                       +GIP     G        Y  MVME LG  L+ +    +  F   TVL
Sbjct: 63  ------------VGIPTIRWCGAEG----DYNVMVMELLGPSLEDLFNFCSRKFSLKTVL 106

Query: 145 QLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQYQ 203
            L  +M+  +EYIH   ++H D+K  N L+G  K  + VY+ D+GL+ +Y     H+   
Sbjct: 107 LLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIP 166

Query: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 263
               K   GT  + S++ H G+  SRR D+E LGY ++ +  G LPW Q LK   A +  
Sbjct: 167 YRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW-QGLK--AATKRQ 223

Query: 264 KTNLLDELPQS-----VLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
           K   + E   S     + K  PS     E A +L    SL +D+KP+Y  L+++
Sbjct: 224 KYERISEKKMSTPIEVLCKGYPS-----EFATYLNFCRSLRFDDKPDYSYLRQL 272


>gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens]
          Length = 415

 Score =  122 bits (306), Expect = 8e-28
 Identities = 95/294 (32%), Positives = 140/294 (47%), Gaps = 34/294 (11%)

Query: 26  GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDC 85
           GN++ LG+KIGSG FG IYL       E+ A  +  V+  ++  L  E K Y+ +     
Sbjct: 6   GNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVK-TKHPQLHIESKIYKMMQGG-- 62

Query: 86  IKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKSTVL 144
                       +GIP     G        Y  MVME LG  L+ +    +  F   TVL
Sbjct: 63  ------------VGIPTIRWCGAEG----DYNVMVMELLGPSLEDLFNFCSRKFSLKTVL 106

Query: 145 QLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQYQ 203
            L  +M+  +EYIH   ++H D+K  N L+G  K  + VY+ D+GL+ +Y     H+   
Sbjct: 107 LLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIP 166

Query: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 263
               K   GT  + S++ H G+  SRR D+E LGY ++ +  G LPW Q LK   A +  
Sbjct: 167 YRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW-QGLK--AATKRQ 223

Query: 264 KTNLLDELPQS-----VLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
           K   + E   S     + K  PS     E A +L    SL +D+KP+Y  L+++
Sbjct: 224 KYERISEKKMSTPIEVLCKGYPS-----EFATYLNFCRSLRFDDKPDYSYLRQL 272


>gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens]
          Length = 337

 Score =  113 bits (282), Expect = 5e-25
 Identities = 89/299 (29%), Positives = 142/299 (47%), Gaps = 28/299 (9%)

Query: 18  GKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELK 75
           G   + + G ++ L +KIGSG FG IYLA      E+ A   VK+E Q+  +  L  E K
Sbjct: 6   GSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVA---VKLESQKARHPQLLYESK 62

Query: 76  FYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ- 134
            Y+ +                 +GIP     G    + + Y  +VM+ LG  L+ +    
Sbjct: 63  LYKILQGG--------------VGIPHIRWYG----QEKDYNVLVMDLLGPSLEDLFNFC 104

Query: 135 NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRY 193
           +  F   TVL L  +M+  +EY+H   ++H DIK  N L+G  ++ ++++L D+GL+ +Y
Sbjct: 105 SRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY 164

Query: 194 CPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQN 253
             N   +       K   GT  + S++AH G+  SRR D+E LGY ++ +    LPW Q 
Sbjct: 165 RDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW-QG 223

Query: 254 LKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
           LK   A +  K   + E   S            E A +L     L ++E P+Y  L+++
Sbjct: 224 LK--AATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQL 280


>gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens]
          Length = 455

 Score =  108 bits (269), Expect = 1e-23
 Identities = 101/369 (27%), Positives = 154/369 (41%), Gaps = 44/369 (11%)

Query: 24  MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP--LFSELKFYQRVA 81
           M G  + +GKKIG G FG + L       E  A   +K+E  ++    L  E +FY+++ 
Sbjct: 38  MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPMKSRAPQLHLEYRFYKQLG 94

Query: 82  KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 140
             D              GIP  Y  G        Y  MV+E LG  L+ +    + TF  
Sbjct: 95  SGD--------------GIPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFSL 136

Query: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 197
            TVL + I+++  +EY+H    ++ D+K  N L+G    K    +++ D+GL+  Y    
Sbjct: 137 KTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPE 196

Query: 198 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 257
             K       K   GT  + S++ H G   SRR D+E LG+  + +L G LPW       
Sbjct: 197 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 249

Query: 258 VAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EIAQFLVCAHSLAYDEKPNYQALKK 311
              Q  K + L E  Q +   K A      C    E+A +L     L + EKP+Y  L+K
Sbjct: 250 ---QGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRK 306

Query: 312 ILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAE 371
           +        G + F  +   I    P       Q  A     +AH    + +    +SA+
Sbjct: 307 LFTDLFDRKGYM-FDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQSAD 365

Query: 372 SCATWKVQK 380
             A W  Q+
Sbjct: 366 HRAAWDSQQ 374


>gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens]
          Length = 447

 Score =  108 bits (269), Expect = 1e-23
 Identities = 101/369 (27%), Positives = 154/369 (41%), Gaps = 44/369 (11%)

Query: 24  MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP--LFSELKFYQRVA 81
           M G  + +GKKIG G FG + L       E  A   +K+E  ++    L  E +FY+++ 
Sbjct: 38  MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPMKSRAPQLHLEYRFYKQLG 94

Query: 82  KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 140
             D              GIP  Y  G        Y  MV+E LG  L+ +    + TF  
Sbjct: 95  SGD--------------GIPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFSL 136

Query: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 197
            TVL + I+++  +EY+H    ++ D+K  N L+G    K    +++ D+GL+  Y    
Sbjct: 137 KTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPE 196

Query: 198 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 257
             K       K   GT  + S++ H G   SRR D+E LG+  + +L G LPW       
Sbjct: 197 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 249

Query: 258 VAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EIAQFLVCAHSLAYDEKPNYQALKK 311
              Q  K + L E  Q +   K A      C    E+A +L     L + EKP+Y  L+K
Sbjct: 250 ---QGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRK 306

Query: 312 ILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAE 371
           +        G + F  +   I    P       Q  A     +AH    + +    +SA+
Sbjct: 307 LFTDLFDRKGYM-FDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQSAD 365

Query: 372 SCATWKVQK 380
             A W  Q+
Sbjct: 366 HRAAWDSQQ 374


>gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens]
          Length = 337

 Score =  106 bits (264), Expect = 6e-23
 Identities = 85/291 (29%), Positives = 137/291 (47%), Gaps = 28/291 (9%)

Query: 26  GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELKFYQRVAKK 83
           G ++ L +KIGSG FG +YL   T   E+ A   VK+E Q+  +  L  E K Y  +   
Sbjct: 14  GGKYKLVRKIGSGSFGDVYLGITTTNGEEVA---VKLESQKVKHPQLLYESKLYTILQGG 70

Query: 84  DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKST 142
                         +GIP  +  G    + +    +VM+ LG  L+ +    +  F   T
Sbjct: 71  --------------VGIPHMHWYG----QEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKT 112

Query: 143 VLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQ 201
           VL L  +M+  +EY+H   ++H DIK  N L+G  ++ ++++L D+GL+ +Y  N   + 
Sbjct: 113 VLMLADQMISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQH 172

Query: 202 YQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQ 261
                 K   GT+ + S++AH G+  SRR D+E LGY  + +    LPW Q LK     +
Sbjct: 173 IPYREDKHLIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPW-QGLK--AMTK 229

Query: 262 TAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
             K   + E   S            E A +L     L ++E P+Y  L+++
Sbjct: 230 KQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQL 280


>gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens]
          Length = 365

 Score =  104 bits (259), Expect = 2e-22
 Identities = 90/327 (27%), Positives = 141/327 (43%), Gaps = 56/327 (17%)

Query: 18  GKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELK 75
           G   + + G ++ L +KIGSG FG IYLA      E+ A   VK+E Q+  +  L  E K
Sbjct: 6   GSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVA---VKLESQKARHPQLLYESK 62

Query: 76  FYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ- 134
            Y+ +                 +GIP     G    + + Y  +VM+ LG  L+ +    
Sbjct: 63  LYKILQGG--------------VGIPHIRWYG----QEKDYNVLVMDLLGPSLEDLFNFC 104

Query: 135 NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLG------------------- 175
           +  F   TVL L  +M+  +EY+H   ++H DIK  N L+G                   
Sbjct: 105 SRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRS 164

Query: 176 ----------YKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGV 225
                     +   +Q++L D+GL+ +Y  N   +       K   GT  + S++AH G+
Sbjct: 165 MTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGI 224

Query: 226 ALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSC 285
             SRR D+E LGY ++ +    LPW Q LK   A +  K   + E   S           
Sbjct: 225 EQSRRDDMESLGYVLMYFNRTSLPW-QGLK--AATKKQKYEKISEKKMSTPVEVLCKGFP 281

Query: 286 CEIAQFLVCAHSLAYDEKPNYQALKKI 312
            E A +L     L ++E P+Y  L+++
Sbjct: 282 AEFAMYLNYCRGLRFEEAPDYMYLRQL 308


>gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens]
          Length = 415

 Score =  103 bits (257), Expect = 4e-22
 Identities = 88/301 (29%), Positives = 133/301 (44%), Gaps = 43/301 (14%)

Query: 24  MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP--LFSELKFYQRVA 81
           M G  + +GKKIG G FG + L       E  A   +K+E  ++    L  E +FY+++ 
Sbjct: 38  MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPMKSRAPQLHLEYRFYKQLG 94

Query: 82  KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 140
             D              GIP  Y  G        Y  MV+E LG  L+ +    + TF  
Sbjct: 95  SGD--------------GIPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFSL 136

Query: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 197
            TVL + I+++  +EY+H    ++ D+K  N L+G    K    +++ D+GL+  Y    
Sbjct: 137 KTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPE 196

Query: 198 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 257
             K       K   GT  + S++ H G   SRR D+E LG+  + +L G LPW       
Sbjct: 197 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 249

Query: 258 VAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EIAQFLVCAHSLAYDEKPNYQALKK 311
              Q  K + L E  Q +   K A      C    E+A +L     L + EKP+Y  L+K
Sbjct: 250 ---QGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRK 306

Query: 312 I 312
           +
Sbjct: 307 L 307


>gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens]
          Length = 423

 Score =  103 bits (257), Expect = 4e-22
 Identities = 88/301 (29%), Positives = 133/301 (44%), Gaps = 43/301 (14%)

Query: 24  MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP--LFSELKFYQRVA 81
           M G  + +GKKIG G FG + L       E  A   +K+E  ++    L  E +FY+++ 
Sbjct: 38  MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPMKSRAPQLHLEYRFYKQLG 94

Query: 82  KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 140
             D              GIP  Y  G        Y  MV+E LG  L+ +    + TF  
Sbjct: 95  SGD--------------GIPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFSL 136

Query: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 197
            TVL + I+++  +EY+H    ++ D+K  N L+G    K    +++ D+GL+  Y    
Sbjct: 137 KTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPE 196

Query: 198 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 257
             K       K   GT  + S++ H G   SRR D+E LG+  + +L G LPW       
Sbjct: 197 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 249

Query: 258 VAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EIAQFLVCAHSLAYDEKPNYQALKK 311
              Q  K + L E  Q +   K A      C    E+A +L     L + EKP+Y  L+K
Sbjct: 250 ---QGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRK 306

Query: 312 I 312
           +
Sbjct: 307 L 307


>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
          Length = 1321

 Score =  100 bits (250), Expect = 2e-21
 Identities = 86/290 (29%), Positives = 135/290 (46%), Gaps = 33/290 (11%)

Query: 27  NQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCI 86
           ++W + KKIG GGFG IY A      E  A  V   + Q    L  E+   +++  KD +
Sbjct: 32  DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQ-QPKQVLKMEVAVLKKLQGKDHV 90

Query: 87  KKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI--SGQNGTFKKSTVL 144
            ++I              G G  E     + ++VM+  G +L  +  S   GTF  ST L
Sbjct: 91  CRFI--------------GCGRNE----KFNYVVMQLQGRNLADLRRSQPRGTFTLSTTL 132

Query: 145 QLGIRMLDVLEYIHENEYVHGDIKAANLLLGY--KNPDQVYLADYGLSYRYCPNGNHKQY 202
           +LG ++L+ +E IH   ++H DIK +N  +G       + Y+ D+GL+ +Y       + 
Sbjct: 133 RLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRP 192

Query: 203 QENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQT 262
             N   G  GT+ + S++AHK   + R  D+  L Y ++ +  G+LPW + +KD   V  
Sbjct: 193 PRNV-AGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPW-RKIKDKEQVGM 250

Query: 263 AKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
            K      +   +LK  PS     E   FL    SL Y  KP+YQ +  +
Sbjct: 251 IKEKYEHRM---LLKHMPS-----EFHLFLDHIASLDYFTKPDYQLIMSV 292


>gi|153791733 casein kinase 1, gamma 2 [Homo sapiens]
          Length = 415

 Score =  100 bits (248), Expect = 4e-21
 Identities = 87/302 (28%), Positives = 134/302 (44%), Gaps = 44/302 (14%)

Query: 24  MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVE-YQENGP-LFSELKFYQRVA 81
           M G  + +GKKIG G FG + L       E  A   +K+E  +   P L  E +FY++++
Sbjct: 41  MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPIKSRAPQLHLEYRFYKQLS 97

Query: 82  KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 140
             +              G+P  Y  G        Y  MV+E LG  L+ +    + TF  
Sbjct: 98  ATE--------------GVPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFTL 139

Query: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 197
            TVL + I+++  +EY+H    ++ D+K  N L+G    K    +++ D+GL+  Y    
Sbjct: 140 KTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPE 199

Query: 198 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 257
             K       K   GT  + S++ H G   SRR D+E LG+  + +L G LPW       
Sbjct: 200 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 252

Query: 258 VAVQTAKTNLLDELPQSV--LKWAPSGSSCC-----EIAQFLVCAHSLAYDEKPNYQALK 310
              Q  K + L E  Q +   K A      C     E+A +L     L + EKP+Y  L+
Sbjct: 253 ---QGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLR 309

Query: 311 KI 312
           K+
Sbjct: 310 KL 311


>gi|98986450 casein kinase 1, gamma 1 [Homo sapiens]
          Length = 422

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 96/348 (27%), Positives = 149/348 (42%), Gaps = 45/348 (12%)

Query: 24  MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVE-YQENGP-LFSELKFYQRVA 81
           M G  + +GKKIG G FG + L       E  A   +K+E  +   P L  E +FY+++ 
Sbjct: 39  MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPIKSRAPQLHLEYRFYKQLG 95

Query: 82  KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 140
                            G+P  Y  G        Y  MV+E LG  L+ +    + TF  
Sbjct: 96  SAG-------------EGLPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFTL 138

Query: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 197
            TVL + I++L  +EY+H    ++ D+K  N L+G    K    +++ D+GL+  Y    
Sbjct: 139 KTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPE 198

Query: 198 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 257
             K       K   GT  + S++ H G   SRR D+E LG+  + +L G LPW       
Sbjct: 199 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 251

Query: 258 VAVQTAKTNLLDELPQSV---LKWAPSGSSC----CEIAQFLVCAHSLAYDEKPNYQALK 310
              Q  K + L E  Q +    +  P  + C     E+A +L     L + EKP+Y+ L+
Sbjct: 252 ---QGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLR 308

Query: 311 KILNPHGIPLG-PLDFSTKGQSINVHTP-NSQKVDSQKAATKQVNKAH 356
            +        G   D++       + TP  S  VDS  +A  + +  H
Sbjct: 309 TLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTH 356


>gi|116812624 tau tubulin kinase 2 [Homo sapiens]
          Length = 1244

 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 84/291 (28%), Positives = 135/291 (46%), Gaps = 33/291 (11%)

Query: 28  QWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIK 87
           +W + +KIG GGFG IY A      E  A  V   + Q    L  E+   +++  KD + 
Sbjct: 20  RWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQ-QPKQVLKMEVAVLKKLQGKDHVC 78

Query: 88  KWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI--SGQNGTFKKSTVLQ 145
           ++I              G G  +     + ++VM+  G +L  +  S   GTF  ST L+
Sbjct: 79  RFI--------------GCGRND----RFNYVVMQLQGRNLADLRRSQSRGTFTISTTLR 120

Query: 146 LGIRMLDVLEYIHENEYVHGDIKAANLLLGY--KNPDQVYLADYGLSYRYCPNGNHKQYQ 203
           LG ++L+ +E IH   ++H DIK +N  +G       + Y+ D+GL+ R   N       
Sbjct: 121 LGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLA-RQFTNSCGDVRP 179

Query: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 263
                G  GT+ + S++AH+   + R  D+  L Y ++ ++ G+LPW + +KD   V + 
Sbjct: 180 PRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPW-RKIKDKEQVGSI 238

Query: 264 KTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILN 314
           K      L   +LK  P      E + FL    SL Y  KP+YQ L  + +
Sbjct: 239 KERYDHRL---MLKHLPP-----EFSIFLDHISSLDYFTKPDYQLLTSVFD 281


>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
            sapiens]
          Length = 1512

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 58/227 (25%), Positives = 97/227 (42%), Gaps = 17/227 (7%)

Query: 25   EGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKD 84
            E  +W+ G++IG G F   Y A         A  V +V Y  N    SE +      ++ 
Sbjct: 1239 EDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMA--VKQVTYVRNTS--SEQEEVVEALRE- 1293

Query: 85   CIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVL 144
                  E + + +L  P          +  +Y   +    G  +  +  + G FK+S V+
Sbjct: 1294 ------EIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVI 1347

Query: 145  QLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHK-QYQ 203
                ++L  L Y+HEN+ +H D+K ANLL+      ++ +AD+G + R    G    ++Q
Sbjct: 1348 NYTEQLLRGLSYLHENQIIHRDVKGANLLID-STGQRLRIADFGAAARLASKGTGAGEFQ 1406

Query: 204  ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPW 250
                    GTI F + +  +G    R  DV  +G  ++   C K PW
Sbjct: 1407 GQLL----GTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPW 1449


>gi|42794767 mitogen-activated protein kinase kinase kinase 3
           isoform 1 [Homo sapiens]
          Length = 657

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 57/227 (25%), Positives = 98/227 (43%), Gaps = 22/227 (9%)

Query: 29  WVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKK 88
           W  GK +G G FG +YL +  +   + A    +V++  + P  S+      V+  +C  +
Sbjct: 393 WRRGKLLGQGAFGRVYLCYDVDTGRELASK--QVQFDPDSPETSK-----EVSALECEIQ 445

Query: 89  WIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGI 148
            +  K L +  I  +YG  L +   ++    +    G  ++      G   +S   +   
Sbjct: 446 LL--KNLQHERIVQYYGC-LRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTR 502

Query: 149 RMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYR---YCPNGNHKQYQEN 205
           ++L+ + Y+H N  VH DIK AN+L    +   V L D+G S R    C +G        
Sbjct: 503 QILEGMSYLHSNMIVHRDIKGANIL--RDSAGNVKLGDFGASKRLQTICMSG-------T 553

Query: 206 PRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQ 252
             +   GT  + S +   G    R++DV  LG  ++  L  K PW +
Sbjct: 554 GMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAE 600


>gi|42794765 mitogen-activated protein kinase kinase kinase 3
           isoform 2 [Homo sapiens]
          Length = 626

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 57/227 (25%), Positives = 98/227 (43%), Gaps = 22/227 (9%)

Query: 29  WVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKK 88
           W  GK +G G FG +YL +  +   + A    +V++  + P  S+      V+  +C  +
Sbjct: 362 WRRGKLLGQGAFGRVYLCYDVDTGRELASK--QVQFDPDSPETSK-----EVSALECEIQ 414

Query: 89  WIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGI 148
            +  K L +  I  +YG  L +   ++    +    G  ++      G   +S   +   
Sbjct: 415 LL--KNLQHERIVQYYGC-LRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTR 471

Query: 149 RMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYR---YCPNGNHKQYQEN 205
           ++L+ + Y+H N  VH DIK AN+L    +   V L D+G S R    C +G        
Sbjct: 472 QILEGMSYLHSNMIVHRDIKGANIL--RDSAGNVKLGDFGASKRLQTICMSG-------T 522

Query: 206 PRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQ 252
             +   GT  + S +   G    R++DV  LG  ++  L  K PW +
Sbjct: 523 GMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAE 569


>gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Homo
           sapiens]
          Length = 619

 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 56/227 (24%), Positives = 99/227 (43%), Gaps = 22/227 (9%)

Query: 29  WVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKK 88
           W LGK +G G FG +YL +  +   + A  V +V++  + P  S+      V   +C  +
Sbjct: 356 WRLGKLLGQGAFGRVYLCYDVDTGRELA--VKQVQFDPDSPETSK-----EVNALECEIQ 408

Query: 89  WIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGI 148
            +  K L +  I  +YG  L + + ++    +    G  ++      G   ++   +   
Sbjct: 409 LL--KNLLHERIVQYYGC-LRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTR 465

Query: 149 RMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYR---YCPNGNHKQYQEN 205
           ++L+ + Y+H N  VH DIK AN+L    +   V L D+G S R    C +G        
Sbjct: 466 QILEGVHYLHSNMIVHRDIKGANIL--RDSTGNVKLGDFGASKRLQTICLSG-------T 516

Query: 206 PRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQ 252
             K   GT  + S +   G    R++D+  +   ++  L  K PW +
Sbjct: 517 GMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAE 563


>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
          Length = 708

 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 67/225 (29%), Positives = 107/225 (47%), Gaps = 29/225 (12%)

Query: 33  KKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIER 92
           K IG G FG  YLA    K + D++H V  E       F ++   ++ A K   K+ I  
Sbjct: 8   KAIGQGAFGKAYLA----KGKSDSKHCVIKEIN-----FEKMPIQEKEASK---KEVILL 55

Query: 93  KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQK-ISGQNGT-FKKSTVLQLGIR 149
           +++ +  I  F+ S    F+     F+VME   G DL K I+ Q G  F +  +L   ++
Sbjct: 56  EKMKHPNIVAFFNS----FQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQ 111

Query: 150 MLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKG 209
           +   L++IH+ + +H DIKA N+ L  KN     L D+G++ R   N           + 
Sbjct: 112 ISLGLKHIHDRKILHRDIKAQNIFLS-KNGMVAKLGDFGIA-RVLNNSMEL------ART 163

Query: 210 HNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCG-KLPWEQN 253
             GT  + S +  +    + ++D+  LG C+L  LC  K P+E N
Sbjct: 164 CIGTPYYLSPEICQNKPYNNKTDIWSLG-CVLYELCTLKHPFEGN 207


>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
          Length = 403

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 63/273 (23%), Positives = 116/273 (42%), Gaps = 52/273 (19%)

Query: 2   PPKRNEKYKLPIPF-----PEGKVL-----DDMEGNQWVL-----GKKIGSGGFGLIYLA 46
           P    +K K P+P      PE ++      ++ +  QW L     G+ +G G FG +YLA
Sbjct: 91  PLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLA 150

Query: 47  FPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIE-RKQLDYLGIPLFYG 105
                 EK ++ ++ ++      L       ++   +  +++ +E +  L +  I   YG
Sbjct: 151 -----REKQSKFILALKVLFKAQL-------EKAGVEHQLRREVEIQSHLRHPNILRLYG 198

Query: 106 SGLTEFKGRSYRFMVMERLGI-----DLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHEN 160
                F   +  ++++E   +     +LQK+S     F +         + + L Y H  
Sbjct: 199 Y----FHDATRVYLILEYAPLGTVYRELQKLS----KFDEQRTATYITELANALSYCHSK 250

Query: 161 EYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLD 220
             +H DIK  NLLLG  +  ++ +AD+G S  + P+          R    GT+++   +
Sbjct: 251 RVIHRDIKPENLLLG--SAGELKIADFGWSV-HAPSSR--------RTTLCGTLDYLPPE 299

Query: 221 AHKGVALSRRSDVEILGYCMLRWLCGKLPWEQN 253
             +G     + D+  LG     +L GK P+E N
Sbjct: 300 MIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAN 332


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,973,942
Number of Sequences: 37866
Number of extensions: 916302
Number of successful extensions: 3402
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 228
Number of HSP's successfully gapped in prelim test: 356
Number of HSP's that attempted gapping in prelim test: 2863
Number of HSP's gapped (non-prelim): 725
length of query: 508
length of database: 18,247,518
effective HSP length: 107
effective length of query: 401
effective length of database: 14,195,856
effective search space: 5692538256
effective search space used: 5692538256
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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