Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 194306559

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194306559 kinesin light chain 1 isoform 3 [Homo sapiens]
         (618 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194306559 kinesin light chain 1 isoform 3 [Homo sapiens]          1225   0.0  
gi|110735431 kinesin light chain 1 isoform 2 [Homo sapiens]          1098   0.0  
gi|33620730 kinesin light chain 1 isoform 1 [Homo sapiens]           1097   0.0  
gi|41871960 kinesin-like 8 isoform b [Homo sapiens]                   808   0.0  
gi|41871955 kinesin-like 8 isoform a [Homo sapiens]                   808   0.0  
gi|41871946 kinesin-like 8 isoform a [Homo sapiens]                   808   0.0  
gi|198041734 kinesin light chain 2 isoform 1 [Homo sapiens]           794   0.0  
gi|198041731 kinesin light chain 2 isoform 1 [Homo sapiens]           794   0.0  
gi|12383062 kinesin light chain 2 isoform 1 [Homo sapiens]            794   0.0  
gi|198041728 kinesin light chain 2 isoform 2 [Homo sapiens]           626   e-179
gi|91825557 kinesin light chain 3 [Homo sapiens]                      513   e-145
gi|19923891 kinesin-like 8 isoform c [Homo sapiens]                   400   e-111
gi|34304360 nephrocystin 3 [Homo sapiens]                             157   2e-38
gi|87162455 hypothetical protein LOC23277 [Homo sapiens]               65   2e-10
gi|18104962 amyloid beta precursor protein-binding protein 2 [Ho...    61   3e-09
gi|22547159 tetratricopeptide repeat domain 19 [Homo sapiens]          56   9e-08
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]       53   7e-07
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]       53   7e-07
gi|224586823 coiled-coil domain containing 110 isoform b [Homo s...    50   6e-06
gi|22749515 coiled-coil domain containing 110 isoform a [Homo sa...    50   6e-06
gi|38044112 restin isoform b [Homo sapiens]                            50   8e-06
gi|4506751 restin isoform a [Homo sapiens]                             50   8e-06
gi|83415184 transmembrane and tetratricopeptide repeat containin...    50   8e-06
gi|110815815 centlein isoform 1 [Homo sapiens]                         49   1e-05
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi...    48   3e-05
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    47   4e-05
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  47   4e-05
gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]         47   7e-05
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]         46   9e-05
gi|56961680 coiled-coil domain containing 147 [Homo sapiens]           46   9e-05

>gi|194306559 kinesin light chain 1 isoform 3 [Homo sapiens]
          Length = 618

 Score = 1225 bits (3169), Expect = 0.0
 Identities = 618/618 (100%), Positives = 618/618 (100%)

Query: 1   MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDD 60
           MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDD
Sbjct: 1   MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDD 60

Query: 61  ESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWL 120
           ESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWL
Sbjct: 61  ESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWL 120

Query: 121 RDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF 180
           RDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
Sbjct: 121 RDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF 180

Query: 181 PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQAL 240
           PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQAL
Sbjct: 181 PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQAL 240

Query: 241 EDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATL 300
           EDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATL
Sbjct: 241 EDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATL 300

Query: 301 NNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEY 360
           NNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEY
Sbjct: 301 NNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEY 360

Query: 361 YYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVD 420
           YYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVD
Sbjct: 361 YYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVD 420

Query: 421 DENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKF 480
           DENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKF
Sbjct: 421 DENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKF 480

Query: 481 EAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGE 540
           EAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGE
Sbjct: 481 EAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGE 540

Query: 541 EVSMSVEWNGDGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPGASLAEP 600
           EVSMSVEWNGDGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPGASLAEP
Sbjct: 541 EVSMSVEWNGDGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPGASLAEP 600

Query: 601 LFVENDSSSSGLEDATAN 618
           LFVENDSSSSGLEDATAN
Sbjct: 601 LFVENDSSSSGLEDATAN 618


>gi|110735431 kinesin light chain 1 isoform 2 [Homo sapiens]
          Length = 573

 Score = 1098 bits (2841), Expect = 0.0
 Identities = 551/554 (99%), Positives = 552/554 (99%)

Query: 1   MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDD 60
           MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDD
Sbjct: 1   MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDD 60

Query: 61  ESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWL 120
           ESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWL
Sbjct: 61  ESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWL 120

Query: 121 RDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF 180
           RDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
Sbjct: 121 RDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF 180

Query: 181 PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQAL 240
           PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQAL
Sbjct: 181 PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQAL 240

Query: 241 EDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATL 300
           EDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATL
Sbjct: 241 EDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATL 300

Query: 301 NNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEY 360
           NNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEY
Sbjct: 301 NNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEY 360

Query: 361 YYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVD 420
           YYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVD
Sbjct: 361 YYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVD 420

Query: 421 DENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKF 480
           DENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKF
Sbjct: 421 DENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKF 480

Query: 481 EAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGE 540
           EAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGE
Sbjct: 481 EAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGE 540

Query: 541 EVSMSVEWNGDGTG 554
           EVSMSVEWNG  +G
Sbjct: 541 EVSMSVEWNGGVSG 554


>gi|33620730 kinesin light chain 1 isoform 1 [Homo sapiens]
          Length = 560

 Score = 1097 bits (2838), Expect = 0.0
 Identities = 550/550 (100%), Positives = 550/550 (100%)

Query: 1   MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDD 60
           MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDD
Sbjct: 1   MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDD 60

Query: 61  ESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWL 120
           ESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWL
Sbjct: 61  ESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWL 120

Query: 121 RDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF 180
           RDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
Sbjct: 121 RDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF 180

Query: 181 PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQAL 240
           PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQAL
Sbjct: 181 PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQAL 240

Query: 241 EDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATL 300
           EDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATL
Sbjct: 241 EDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATL 300

Query: 301 NNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEY 360
           NNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEY
Sbjct: 301 NNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEY 360

Query: 361 YYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVD 420
           YYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVD
Sbjct: 361 YYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVD 420

Query: 421 DENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKF 480
           DENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKF
Sbjct: 421 DENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKF 480

Query: 481 EAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGE 540
           EAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGE
Sbjct: 481 EAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGE 540

Query: 541 EVSMSVEWNG 550
           EVSMSVEWNG
Sbjct: 541 EVSMSVEWNG 550


>gi|41871960 kinesin-like 8 isoform b [Homo sapiens]
          Length = 637

 Score =  808 bits (2088), Expect = 0.0
 Identities = 414/600 (69%), Positives = 497/600 (82%), Gaps = 16/600 (2%)

Query: 18  KLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDD-ESNLVEEKSNMIRKSL 76
           +L+Q+EI+  T+ V QGLEAL++EH ++LQSL +T++CL++   E  LV EK+  +R+S+
Sbjct: 34  RLSQEEILGSTRLVSQGLEALRSEHQAVLQSLSQTIECLQQGGHEEGLVHEKARQLRRSM 93

Query: 77  EMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQ 136
           E +ELGLSEAQVM+AL++HL+ VESEKQKLRAQVRRLCQENQWLRDELA TQQ+LQ+SEQ
Sbjct: 94  ENIELGLSEAQVMLALASHLSTVESEKQKLRAQVRRLCQENQWLRDELAGTQQRLQRSEQ 153

Query: 137 SVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDED-DPGQGIQQQH 195
           +VAQLEEEKKHLEF+ QL++YD+D   SE+K+ D+TK+ LDDLFPN+E+ DP  G+ +  
Sbjct: 154 AVAQLEEEKKHLEFLGQLRQYDEDGHTSEEKEGDATKDSLDDLFPNEEEEDPSNGLSR-- 211

Query: 196 SSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVA 255
              A AAQQGGYEIPARLRTLHNLVIQYA+QGRYEVAVPLCKQALEDLE+TSG  HPDVA
Sbjct: 212 GQGATAAQQGGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVA 271

Query: 256 TMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKE 315
           TMLNILALVYRDQNKYK+AA+LLNDAL+IRE TLG DHPAVAATLNNLAVLYGKRGKYKE
Sbjct: 272 TMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKE 331

Query: 316 AEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGP 375
           AEPLC+RALEIREKVLG +HPDVAKQLNNLALLCQNQGKYE VE YYQRAL IY+ +LGP
Sbjct: 332 AEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGP 391

Query: 376 DDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREE 435
           D+PNVA+TKNNLASCYLKQGK+ +AETLYKEILTRAH +EFGSVDD++KPIWMHAEEREE
Sbjct: 392 DNPNVARTKNNLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDDHKPIWMHAEEREE 451

Query: 436 CKGKQ--KDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRS 493
               +  + GT + EYGGWYKACKV SPTV TTL+NLGALYRRQGK EAAETLEE A+RS
Sbjct: 452 MSKSRHHEGGTPYAEYGGWYKACKVSSPTVNTTLRNLGALYRRQGKLEAAETLEECALRS 511

Query: 494 RKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGDGT 553
           R+QG D + + +VAE+L + +    RR+ +    D VK+E    GGE+ S++VEW+GDG+
Sbjct: 512 RRQGTDPISQTKVAELLGESDG---RRTSQEGPGDSVKFE----GGEDASVAVEWSGDGS 564

Query: 554 GSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPGASLAEPLFVENDSSSSGLE 613
           G+L+RSGS  K+R  +RRSSE LVRKL+G    E  P +     A  L   N  S++ L+
Sbjct: 565 GTLQRSGSLGKIRDVLRRSSELLVRKLQG---TEPRPSSSNMKRAASLNYLNQPSAAPLQ 621


>gi|41871955 kinesin-like 8 isoform a [Homo sapiens]
          Length = 619

 Score =  808 bits (2088), Expect = 0.0
 Identities = 414/600 (69%), Positives = 497/600 (82%), Gaps = 16/600 (2%)

Query: 18  KLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDD-ESNLVEEKSNMIRKSL 76
           +L+Q+EI+  T+ V QGLEAL++EH ++LQSL +T++CL++   E  LV EK+  +R+S+
Sbjct: 16  RLSQEEILGSTRLVSQGLEALRSEHQAVLQSLSQTIECLQQGGHEEGLVHEKARQLRRSM 75

Query: 77  EMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQ 136
           E +ELGLSEAQVM+AL++HL+ VESEKQKLRAQVRRLCQENQWLRDELA TQQ+LQ+SEQ
Sbjct: 76  ENIELGLSEAQVMLALASHLSTVESEKQKLRAQVRRLCQENQWLRDELAGTQQRLQRSEQ 135

Query: 137 SVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDED-DPGQGIQQQH 195
           +VAQLEEEKKHLEF+ QL++YD+D   SE+K+ D+TK+ LDDLFPN+E+ DP  G+ +  
Sbjct: 136 AVAQLEEEKKHLEFLGQLRQYDEDGHTSEEKEGDATKDSLDDLFPNEEEEDPSNGLSR-- 193

Query: 196 SSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVA 255
              A AAQQGGYEIPARLRTLHNLVIQYA+QGRYEVAVPLCKQALEDLE+TSG  HPDVA
Sbjct: 194 GQGATAAQQGGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVA 253

Query: 256 TMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKE 315
           TMLNILALVYRDQNKYK+AA+LLNDAL+IRE TLG DHPAVAATLNNLAVLYGKRGKYKE
Sbjct: 254 TMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKE 313

Query: 316 AEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGP 375
           AEPLC+RALEIREKVLG +HPDVAKQLNNLALLCQNQGKYE VE YYQRAL IY+ +LGP
Sbjct: 314 AEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGP 373

Query: 376 DDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREE 435
           D+PNVA+TKNNLASCYLKQGK+ +AETLYKEILTRAH +EFGSVDD++KPIWMHAEEREE
Sbjct: 374 DNPNVARTKNNLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDDHKPIWMHAEEREE 433

Query: 436 CKGKQ--KDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRS 493
               +  + GT + EYGGWYKACKV SPTV TTL+NLGALYRRQGK EAAETLEE A+RS
Sbjct: 434 MSKSRHHEGGTPYAEYGGWYKACKVSSPTVNTTLRNLGALYRRQGKLEAAETLEECALRS 493

Query: 494 RKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGDGT 553
           R+QG D + + +VAE+L + +    RR+ +    D VK+E    GGE+ S++VEW+GDG+
Sbjct: 494 RRQGTDPISQTKVAELLGESDG---RRTSQEGPGDSVKFE----GGEDASVAVEWSGDGS 546

Query: 554 GSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPGASLAEPLFVENDSSSSGLE 613
           G+L+RSGS  K+R  +RRSSE LVRKL+G    E  P +     A  L   N  S++ L+
Sbjct: 547 GTLQRSGSLGKIRDVLRRSSELLVRKLQG---TEPRPSSSNMKRAASLNYLNQPSAAPLQ 603


>gi|41871946 kinesin-like 8 isoform a [Homo sapiens]
          Length = 619

 Score =  808 bits (2088), Expect = 0.0
 Identities = 414/600 (69%), Positives = 497/600 (82%), Gaps = 16/600 (2%)

Query: 18  KLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDD-ESNLVEEKSNMIRKSL 76
           +L+Q+EI+  T+ V QGLEAL++EH ++LQSL +T++CL++   E  LV EK+  +R+S+
Sbjct: 16  RLSQEEILGSTRLVSQGLEALRSEHQAVLQSLSQTIECLQQGGHEEGLVHEKARQLRRSM 75

Query: 77  EMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQ 136
           E +ELGLSEAQVM+AL++HL+ VESEKQKLRAQVRRLCQENQWLRDELA TQQ+LQ+SEQ
Sbjct: 76  ENIELGLSEAQVMLALASHLSTVESEKQKLRAQVRRLCQENQWLRDELAGTQQRLQRSEQ 135

Query: 137 SVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDED-DPGQGIQQQH 195
           +VAQLEEEKKHLEF+ QL++YD+D   SE+K+ D+TK+ LDDLFPN+E+ DP  G+ +  
Sbjct: 136 AVAQLEEEKKHLEFLGQLRQYDEDGHTSEEKEGDATKDSLDDLFPNEEEEDPSNGLSR-- 193

Query: 196 SSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVA 255
              A AAQQGGYEIPARLRTLHNLVIQYA+QGRYEVAVPLCKQALEDLE+TSG  HPDVA
Sbjct: 194 GQGATAAQQGGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVA 253

Query: 256 TMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKE 315
           TMLNILALVYRDQNKYK+AA+LLNDAL+IRE TLG DHPAVAATLNNLAVLYGKRGKYKE
Sbjct: 254 TMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKE 313

Query: 316 AEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGP 375
           AEPLC+RALEIREKVLG +HPDVAKQLNNLALLCQNQGKYE VE YYQRAL IY+ +LGP
Sbjct: 314 AEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGP 373

Query: 376 DDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREE 435
           D+PNVA+TKNNLASCYLKQGK+ +AETLYKEILTRAH +EFGSVDD++KPIWMHAEEREE
Sbjct: 374 DNPNVARTKNNLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDDHKPIWMHAEEREE 433

Query: 436 CKGKQ--KDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRS 493
               +  + GT + EYGGWYKACKV SPTV TTL+NLGALYRRQGK EAAETLEE A+RS
Sbjct: 434 MSKSRHHEGGTPYAEYGGWYKACKVSSPTVNTTLRNLGALYRRQGKLEAAETLEECALRS 493

Query: 494 RKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGDGT 553
           R+QG D + + +VAE+L + +    RR+ +    D VK+E    GGE+ S++VEW+GDG+
Sbjct: 494 RRQGTDPISQTKVAELLGESDG---RRTSQEGPGDSVKFE----GGEDASVAVEWSGDGS 546

Query: 554 GSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPGASLAEPLFVENDSSSSGLE 613
           G+L+RSGS  K+R  +RRSSE LVRKL+G    E  P +     A  L   N  S++ L+
Sbjct: 547 GTLQRSGSLGKIRDVLRRSSELLVRKLQG---TEPRPSSSNMKRAASLNYLNQPSAAPLQ 603


>gi|198041734 kinesin light chain 2 isoform 1 [Homo sapiens]
          Length = 622

 Score =  794 bits (2051), Expect = 0.0
 Identities = 417/605 (68%), Positives = 486/605 (80%), Gaps = 18/605 (2%)

Query: 5   MSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNL 64
           M+ MV+ +E   EKL+QDEI+  TK VIQGLE L+ EH ++L  L+      +  +    
Sbjct: 1   MAMMVFPRE---EKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVAP----EAGEAEPG 53

Query: 65  VEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDEL 124
            +E+  ++R+SLE +ELGL EAQV++ALS+HL AVESEKQKLRAQVRRL QENQWLR+EL
Sbjct: 54  SQERCILLRRSLEAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREEL 113

Query: 125 ANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDE 184
           A TQQKLQ+SEQ+VAQLEEEK+HL FM+Q++K D+D SP+E+K  D  K+ LDDLFPN++
Sbjct: 114 AGTQQKLQRSEQAVAQLEEEKQHLLFMSQIRKLDEDASPNEEKG-DVPKDTLDDLFPNED 172

Query: 185 DDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLE 244
           +   Q           + Q GGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLE
Sbjct: 173 E---QSPAPSPGGGDVSGQHGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLE 229

Query: 245 KTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLA 304
           KTSGHDHPDVATMLNILALVYRDQNKYK+AA+LLNDALAIREKTLGKDHPAVAATLNNLA
Sbjct: 230 KTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLA 289

Query: 305 VLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQR 364
           VLYGKRGKYKEAEPLCKRALEIREKVLGK HPDVAKQL+NLALLCQNQGK EEVEYYY+R
Sbjct: 290 VLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRR 349

Query: 365 ALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENK 424
           ALEIY T+LGPDDPNVAKTKNNLASCYLKQGK++ AETLYKEILTRAHE+EFGSV+ +NK
Sbjct: 350 ALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDNK 409

Query: 425 PIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAE 484
           PIWMHAEEREE K K++D   +GEYG WYKACKVDSPTV TTL++LGALYRRQGK EAA 
Sbjct: 410 PIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNTTLRSLGALYRRQGKLEAAH 469

Query: 485 TLEEAAMRSRKQGLDNVHKQRVAEVLNDPENM--EKRRSRESLNVDVVKYESGPDGGEEV 542
           TLE+ A R+RKQGLD   + +V E+L D      ++R SR+       + ES     E+V
Sbjct: 470 TLEDCASRNRKQGLDPASQTKVVELLKDGSGRRGDRRSSRDMAGGAGPRSESDL---EDV 526

Query: 543 SMSVEWNGDGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPGASLAEPLF 602
             + EWNGDG+GSL+RSGSF KLR ++RRSSE LV+KL+GG+ +  EP NP    A  L 
Sbjct: 527 GPTAEWNGDGSGSLRRSGSFGKLRDALRRSSEMLVKKLQGGTPQ--EPPNPRMKRASSLN 584

Query: 603 VENDS 607
             N S
Sbjct: 585 FLNKS 589


>gi|198041731 kinesin light chain 2 isoform 1 [Homo sapiens]
          Length = 622

 Score =  794 bits (2051), Expect = 0.0
 Identities = 417/605 (68%), Positives = 486/605 (80%), Gaps = 18/605 (2%)

Query: 5   MSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNL 64
           M+ MV+ +E   EKL+QDEI+  TK VIQGLE L+ EH ++L  L+      +  +    
Sbjct: 1   MAMMVFPRE---EKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVAP----EAGEAEPG 53

Query: 65  VEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDEL 124
            +E+  ++R+SLE +ELGL EAQV++ALS+HL AVESEKQKLRAQVRRL QENQWLR+EL
Sbjct: 54  SQERCILLRRSLEAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREEL 113

Query: 125 ANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDE 184
           A TQQKLQ+SEQ+VAQLEEEK+HL FM+Q++K D+D SP+E+K  D  K+ LDDLFPN++
Sbjct: 114 AGTQQKLQRSEQAVAQLEEEKQHLLFMSQIRKLDEDASPNEEKG-DVPKDTLDDLFPNED 172

Query: 185 DDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLE 244
           +   Q           + Q GGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLE
Sbjct: 173 E---QSPAPSPGGGDVSGQHGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLE 229

Query: 245 KTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLA 304
           KTSGHDHPDVATMLNILALVYRDQNKYK+AA+LLNDALAIREKTLGKDHPAVAATLNNLA
Sbjct: 230 KTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLA 289

Query: 305 VLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQR 364
           VLYGKRGKYKEAEPLCKRALEIREKVLGK HPDVAKQL+NLALLCQNQGK EEVEYYY+R
Sbjct: 290 VLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRR 349

Query: 365 ALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENK 424
           ALEIY T+LGPDDPNVAKTKNNLASCYLKQGK++ AETLYKEILTRAHE+EFGSV+ +NK
Sbjct: 350 ALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDNK 409

Query: 425 PIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAE 484
           PIWMHAEEREE K K++D   +GEYG WYKACKVDSPTV TTL++LGALYRRQGK EAA 
Sbjct: 410 PIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNTTLRSLGALYRRQGKLEAAH 469

Query: 485 TLEEAAMRSRKQGLDNVHKQRVAEVLNDPENM--EKRRSRESLNVDVVKYESGPDGGEEV 542
           TLE+ A R+RKQGLD   + +V E+L D      ++R SR+       + ES     E+V
Sbjct: 470 TLEDCASRNRKQGLDPASQTKVVELLKDGSGRRGDRRSSRDMAGGAGPRSESDL---EDV 526

Query: 543 SMSVEWNGDGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPGASLAEPLF 602
             + EWNGDG+GSL+RSGSF KLR ++RRSSE LV+KL+GG+ +  EP NP    A  L 
Sbjct: 527 GPTAEWNGDGSGSLRRSGSFGKLRDALRRSSEMLVKKLQGGTPQ--EPPNPRMKRASSLN 584

Query: 603 VENDS 607
             N S
Sbjct: 585 FLNKS 589


>gi|12383062 kinesin light chain 2 isoform 1 [Homo sapiens]
          Length = 622

 Score =  794 bits (2051), Expect = 0.0
 Identities = 417/605 (68%), Positives = 486/605 (80%), Gaps = 18/605 (2%)

Query: 5   MSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNL 64
           M+ MV+ +E   EKL+QDEI+  TK VIQGLE L+ EH ++L  L+      +  +    
Sbjct: 1   MAMMVFPRE---EKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVAP----EAGEAEPG 53

Query: 65  VEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDEL 124
            +E+  ++R+SLE +ELGL EAQV++ALS+HL AVESEKQKLRAQVRRL QENQWLR+EL
Sbjct: 54  SQERCILLRRSLEAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREEL 113

Query: 125 ANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDE 184
           A TQQKLQ+SEQ+VAQLEEEK+HL FM+Q++K D+D SP+E+K  D  K+ LDDLFPN++
Sbjct: 114 AGTQQKLQRSEQAVAQLEEEKQHLLFMSQIRKLDEDASPNEEKG-DVPKDTLDDLFPNED 172

Query: 185 DDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLE 244
           +   Q           + Q GGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLE
Sbjct: 173 E---QSPAPSPGGGDVSGQHGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLE 229

Query: 245 KTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLA 304
           KTSGHDHPDVATMLNILALVYRDQNKYK+AA+LLNDALAIREKTLGKDHPAVAATLNNLA
Sbjct: 230 KTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLA 289

Query: 305 VLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQR 364
           VLYGKRGKYKEAEPLCKRALEIREKVLGK HPDVAKQL+NLALLCQNQGK EEVEYYY+R
Sbjct: 290 VLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRR 349

Query: 365 ALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENK 424
           ALEIY T+LGPDDPNVAKTKNNLASCYLKQGK++ AETLYKEILTRAHE+EFGSV+ +NK
Sbjct: 350 ALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDNK 409

Query: 425 PIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAE 484
           PIWMHAEEREE K K++D   +GEYG WYKACKVDSPTV TTL++LGALYRRQGK EAA 
Sbjct: 410 PIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNTTLRSLGALYRRQGKLEAAH 469

Query: 485 TLEEAAMRSRKQGLDNVHKQRVAEVLNDPENM--EKRRSRESLNVDVVKYESGPDGGEEV 542
           TLE+ A R+RKQGLD   + +V E+L D      ++R SR+       + ES     E+V
Sbjct: 470 TLEDCASRNRKQGLDPASQTKVVELLKDGSGRRGDRRSSRDMAGGAGPRSESDL---EDV 526

Query: 543 SMSVEWNGDGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPGASLAEPLF 602
             + EWNGDG+GSL+RSGSF KLR ++RRSSE LV+KL+GG+ +  EP NP    A  L 
Sbjct: 527 GPTAEWNGDGSGSLRRSGSFGKLRDALRRSSEMLVKKLQGGTPQ--EPPNPRMKRASSLN 584

Query: 603 VENDS 607
             N S
Sbjct: 585 FLNKS 589


>gi|198041728 kinesin light chain 2 isoform 2 [Homo sapiens]
          Length = 545

 Score =  626 bits (1614), Expect = e-179
 Identities = 328/499 (65%), Positives = 382/499 (76%), Gaps = 10/499 (2%)

Query: 111 RRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTD 170
           + + Q  + LR E       L   E   A+   +++ +     L+  +  +  ++++  D
Sbjct: 22  KAVIQGLETLRGEHRALLAPLVAPEAGEAEPGSQERCILLRRSLEAIELGLGEAQEEKGD 81

Query: 171 STKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYE 230
             K+ LDDLFPN+++   Q           + Q GGYEIPARLRTLHNLVIQYASQGRYE
Sbjct: 82  VPKDTLDDLFPNEDE---QSPAPSPGGGDVSGQHGGYEIPARLRTLHNLVIQYASQGRYE 138

Query: 231 VAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLG 290
           VAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYK+AA+LLNDALAIREKTLG
Sbjct: 139 VAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTLG 198

Query: 291 KDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQ 350
           KDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGK HPDVAKQL+NLALLCQ
Sbjct: 199 KDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQ 258

Query: 351 NQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTR 410
           NQGK EEVEYYY+RALEIY T+LGPDDPNVAKTKNNLASCYLKQGK++ AETLYKEILTR
Sbjct: 259 NQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTR 318

Query: 411 AHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNL 470
           AHE+EFGSV+ +NKPIWMHAEEREE K K++D   +GEYG WYKACKVDSPTV TTL++L
Sbjct: 319 AHEKEFGSVNGDNKPIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNTTLRSL 378

Query: 471 GALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENM--EKRRSRESLNVD 528
           GALYRRQGK EAA TLE+ A R+RKQGLD   + +V E+L D      ++R SR+     
Sbjct: 379 GALYRRQGKLEAAHTLEDCASRNRKQGLDPASQTKVVELLKDGSGRRGDRRSSRDMAGGA 438

Query: 529 VVKYESGPDGGEEVSMSVEWNGDGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRES 588
             + ES     E+V  + EWNGDG+GSL+RSGSF KLR ++RRSSE LV+KL+GG+ +  
Sbjct: 439 GPRSESDL---EDVGPTAEWNGDGSGSLRRSGSFGKLRDALRRSSEMLVKKLQGGTPQ-- 493

Query: 589 EPKNPGASLAEPLFVENDS 607
           EP NP    A  L   N S
Sbjct: 494 EPPNPRMKRASSLNFLNKS 512



 Score =  143 bits (361), Expect = 4e-34
 Identities = 128/413 (30%), Positives = 195/413 (47%), Gaps = 33/413 (7%)

Query: 5   MSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNL 64
           M+ MV+ +E   EKL+QDEI+  TK VIQGLE L+ EH ++L  L+      +  +    
Sbjct: 1   MAMMVFPRE---EKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVAP----EAGEAEPG 53

Query: 65  VEEKSNMIRKSLEMLELGLSEAQ-----VMMALSNHLNAVESEKQKLRAQVRRLCQENQW 119
            +E+  ++R+SLE +ELGL EAQ     V     + L   E E+    +           
Sbjct: 54  SQERCILLRRSLEAIELGLGEAQEEKGDVPKDTLDDLFPNEDEQSPAPSPGGGDVSGQHG 113

Query: 120 LRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLD-- 177
             +  A    +L+     V Q   + ++   +   K+  +D+  +   D       L+  
Sbjct: 114 GYEIPA----RLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNIL 169

Query: 178 DLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCK 237
            L   D++   +     + + A   +  G + PA   TL+NL + Y  +G+Y+ A PLCK
Sbjct: 170 ALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCK 229

Query: 238 QALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVA 297
           +ALE  EK  G  HPDVA  L+ LAL+ ++Q K ++       AL I    LG D P VA
Sbjct: 230 RALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVA 289

Query: 298 ATLNNLAVLYGKRGKYKEAEPLCKRAL-EIREKVLGKDHPD------VAKQLNNLALLCQ 350
            T NNLA  Y K+GKY++AE L K  L    EK  G  + D       A++        +
Sbjct: 290 KTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDNKPIWMHAEEREESKDKRR 349

Query: 351 NQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETL 403
           +   Y E   +Y +A ++       D P V  T  +L + Y +QGK + A TL
Sbjct: 350 DSAPYGEYGSWY-KACKV-------DSPTVNTTLRSLGALYRRQGKLEAAHTL 394


>gi|91825557 kinesin light chain 3 [Homo sapiens]
          Length = 504

 Score =  513 bits (1321), Expect = e-145
 Identities = 259/392 (66%), Positives = 321/392 (81%), Gaps = 5/392 (1%)

Query: 17  EKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSL 76
           E+L+ +E++ +T+QV+QGLEAL+ EH+ +   L E L          ++EEK  ++  SL
Sbjct: 16  ERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSL 75

Query: 77  EMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQ 136
           E +ELGL EAQV++ALS H+ A+E+EKQ+LR+Q RRL QEN WLR+EL  TQ++L+ SE+
Sbjct: 76  EAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEE 135

Query: 137 SVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDEDDPGQGIQQQHS 196
           SVAQLEEEK+HLEF+ QL++YD   + S+  ++   ++ L  LFP++E++     +   +
Sbjct: 136 SVAQLEEEKRHLEFLGQLRQYDPP-AESQQSESPPRRDSLASLFPSEEEER----KGPEA 190

Query: 197 SAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVAT 256
           + AAAAQQGGYEIPARLRTLHNLVIQYA QGRYEVAVPLC+QALEDLE++SGH HPDVAT
Sbjct: 191 AGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVAT 250

Query: 257 MLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEA 316
           MLNILALVYRDQNKYK+A +LL+DAL IRE+TLG +HPAVAATLNNLAVLYGKRG+Y+EA
Sbjct: 251 MLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREA 310

Query: 317 EPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPD 376
           EPLC+RALEIREKVLG DHPDVAKQLNNLALLCQNQGK+E+VE +Y RAL IY+   GP 
Sbjct: 311 EPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPH 370

Query: 377 DPNVAKTKNNLASCYLKQGKFKQAETLYKEIL 408
           DPNVAKTKNNLAS YLKQ K++QAE LYKEIL
Sbjct: 371 DPNVAKTKNNLASAYLKQNKYQQAEELYKEIL 402



 Score =  137 bits (346), Expect = 2e-32
 Identities = 104/299 (34%), Positives = 143/299 (47%), Gaps = 52/299 (17%)

Query: 290 GKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLC 349
           G + PA   TL+NL + Y  +G+Y+ A PLC++ALE  E+  G  HPDVA  LN LAL+ 
Sbjct: 200 GYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVY 259

Query: 350 QNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILT 409
           ++Q KY+E       AL+I +  LGP+ P VA T NNLA  Y K+G++++AE L +  L 
Sbjct: 260 RDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRAL- 318

Query: 410 RAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKN 469
                                E RE+  G                    D P V   L N
Sbjct: 319 ---------------------EIREKVLG-------------------ADHPDVAKQLNN 338

Query: 470 LGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPEN----MEKRRSRESL 525
           L  L + QGKFE  E     A+ S  + L   H   VA+  N+  +      K +  E L
Sbjct: 339 LALLCQNQGKFEDVERHYARAL-SIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEEL 397

Query: 526 NVDVVKYES--GPDGGEEVSMSVEWNGDGTGSLKRSGSFSKLRASIRRSSEKLVRKLKG 582
             +++  E    P G      +    GD   +L+RS S SK+R SIRR SEKLV +L+G
Sbjct: 398 YKEILHKEDLPAPLGAPNTGTA----GDAEQALRRSSSLSKIRESIRRGSEKLVSRLRG 452


>gi|19923891 kinesin-like 8 isoform c [Homo sapiens]
          Length = 315

 Score =  400 bits (1029), Expect = e-111
 Identities = 201/282 (71%), Positives = 245/282 (86%), Gaps = 4/282 (1%)

Query: 18  KLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDD-ESNLVEEKSNMIRKSL 76
           +L+Q+EI+  T+ V QGLEAL++EH ++LQSL +T++CL++   E  LV EK+  +R+S+
Sbjct: 16  RLSQEEILGSTRLVSQGLEALRSEHQAVLQSLSQTIECLQQGGHEEGLVHEKARQLRRSM 75

Query: 77  EMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQ 136
           E +ELGLSEAQVM+AL++HL+ VESEKQKLRAQVRRLCQENQWLRDELA TQQ+LQ+SEQ
Sbjct: 76  ENIELGLSEAQVMLALASHLSTVESEKQKLRAQVRRLCQENQWLRDELAGTQQRLQRSEQ 135

Query: 137 SVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPN-DEDDPGQGIQQQH 195
           +VAQLEEEKKHLEF+ QL++YD+D   SE+K+ D+TK+ LDDLFPN +E+DP  G+ +  
Sbjct: 136 AVAQLEEEKKHLEFLGQLRQYDEDGHTSEEKEGDATKDSLDDLFPNEEEEDPSNGLSR-- 193

Query: 196 SSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVA 255
              A AAQQGGYEIPARLRTLHNLVIQYA+QGRYEVAVPLCKQALEDLE+TSG  HPDVA
Sbjct: 194 GQGATAAQQGGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVA 253

Query: 256 TMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVA 297
           TMLNILALVYRDQNKYK+AA+LLNDAL+IRE TLG DHPAV+
Sbjct: 254 TMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVS 295



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 43/92 (46%), Positives = 60/92 (65%)

Query: 290 GKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLC 349
           G + PA   TL+NL + Y  +G+Y+ A PLCK+ALE  E+  G+ HPDVA  LN LAL+ 
Sbjct: 204 GYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVY 263

Query: 350 QNQGKYEEVEYYYQRALEIYQTKLGPDDPNVA 381
           ++Q KY+E  +    AL I ++ LGPD P V+
Sbjct: 264 RDQNKYKEAAHLLNDALSIRESTLGPDHPAVS 295



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 26/78 (33%), Positives = 39/78 (50%)

Query: 332 GKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCY 391
           G + P   + L+NL +    QG+YE      ++ALE  +   G   P+VA   N LA  Y
Sbjct: 204 GYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVY 263

Query: 392 LKQGKFKQAETLYKEILT 409
             Q K+K+A  L  + L+
Sbjct: 264 RDQNKYKEAAHLLNDALS 281


>gi|34304360 nephrocystin 3 [Homo sapiens]
          Length = 1330

 Score =  157 bits (398), Expect = 2e-38
 Identities = 149/501 (29%), Positives = 211/501 (42%), Gaps = 101/501 (20%)

Query: 69   SNMIRKSLEMLELGLSEAQVMMALSNHLNAV---ESEKQKLRAQVRRL-CQENQWLRD-- 122
            S+  +K +    L LS+ +V    ++ L  +   +  KQKL   +  L   +N + R   
Sbjct: 842  SSYRQKLINYFTLQLSQDRVTWRSADELPWLFQQQGSKQKLHDCLLNLFVSQNLYKRGHF 901

Query: 123  -ELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFP 181
             EL +  Q + K + ++A         E+ + LK+Y+ +    E +D  S    L +   
Sbjct: 902  AELLSYWQFVGKDKSAMAT--------EYFDSLKQYEKNC---EGEDNMSCLADLYETLG 950

Query: 182  NDEDDPG---QGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQ 238
                D G   Q I     S          + P   ++LH L   Y    ++  A  L KQ
Sbjct: 951  RFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQ 1010

Query: 239  ALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDA------------------------ 274
            ALE  E   G DHP  A  L  LA +Y+ QNKY+ A                        
Sbjct: 1011 ALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGF 1070

Query: 275  ANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKD 334
            A L   AL + E TLGKD P  A TLN L VLY  +   + A+   KR+LE+RE+VLG D
Sbjct: 1071 ALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPD 1130

Query: 335  HPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQ 394
            HPD A+ LNNLA LC  + +Y++ E  Y+RAL+I +  L PD P++A T  +LA  Y K 
Sbjct: 1131 HPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKM 1190

Query: 395  GKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYK 454
            GK  +A  LY E+     ++ FG                                     
Sbjct: 1191 GKLDKAVPLY-ELAVEIRQKSFGP------------------------------------ 1213

Query: 455  ACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPE 514
                  P+V T L NL  LY +  K   A  L E A++  +  L  +H  RV E L    
Sbjct: 1214 ----KHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMH-PRVGETLK--- 1265

Query: 515  NMEKRRSRESLNVDVVKYESG 535
                       N+ V+ YE G
Sbjct: 1266 -----------NLAVLSYEGG 1275



 Score =  112 bits (280), Expect = 1e-24
 Identities = 114/399 (28%), Positives = 181/399 (45%), Gaps = 40/399 (10%)

Query: 5    MSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNL 64
            +S   ++ +DK    T  E     KQ  +  E    ++ S L  L ETL    KD    L
Sbjct: 905  LSYWQFVGKDKSAMAT--EYFDSLKQYEKNCEG--EDNMSCLADLYETLGRFLKD--LGL 958

Query: 65   VEEKSNMIRKSLEMLELGLSEAQVMMALSNHL------------NAVESEKQKLRAQVRR 112
            + +    +++SLE+ E  L      +A S H             NA +  KQ L      
Sbjct: 959  LSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENA 1018

Query: 113  LCQENQWLRDEL---ANTQQKLQKSEQS---------VAQLEEEKK-HLEFMNQLKKYDD 159
               ++ +   EL   A   QK  K EQ+         + Q   +KK +L     L++   
Sbjct: 1019 YGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRAL 1078

Query: 160  DISP-SEDKDTDSTKEPLDDL-----FPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARL 213
             +   +  KDT      L++L       N+ +   Q +++   S     +  G + P   
Sbjct: 1079 QLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKR---SLEMRERVLGPDHPDCA 1135

Query: 214  RTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKD 273
            ++L+NL      + +Y+ A  L ++AL+   +    DHP +A  +  LA++Y+   K   
Sbjct: 1136 QSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDK 1195

Query: 274  AANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGK 333
            A  L   A+ IR+K+ G  HP+VA  L NLAVLY +  K+ EA PL +RAL+I E  LG+
Sbjct: 1196 AVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGR 1255

Query: 334  DHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTK 372
             HP V + L NLA+L    G +E+    Y+RA+EI + +
Sbjct: 1256 MHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAE 1294



 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 70/266 (26%), Positives = 114/266 (42%), Gaps = 25/266 (9%)

Query: 280  DALAIREKTL-GKDHPAVAATL-NNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPD 337
            D+L   EK   G+D+ +  A L   L       G   +A    +R+LEIRE  L  DHP 
Sbjct: 924  DSLKQYEKNCEGEDNMSCLADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPR 983

Query: 338  VAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKF 397
            VA+ L+ LA +     K+   E  Y++ALEI +   G D P  A+    LA+ Y KQ K+
Sbjct: 984  VAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKY 1043

Query: 398  KQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACK 457
            +QAE   K+   + H++      +      ++       +  Q +  + G+         
Sbjct: 1044 EQAEHFRKKSF-KIHQKAIKKKGN------LYGFALLRRRALQLEELTLGK--------- 1087

Query: 458  VDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHK------QRVAEVLN 511
             D+P    TL  LG LY  Q   E A+   + ++  R++ L   H         +A + N
Sbjct: 1088 -DTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCN 1146

Query: 512  DPENMEKRRSRESLNVDVVKYESGPD 537
            + +  +K        +D+ +    PD
Sbjct: 1147 EKKQYDKAEELYERALDIRRRALAPD 1172


>gi|87162455 hypothetical protein LOC23277 [Homo sapiens]
          Length = 1309

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 49/196 (25%), Positives = 84/196 (42%), Gaps = 7/196 (3%)

Query: 226  QGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIR 285
            QG  +    L  +AL       G  H +    L +LA ++     Y +A +    A+ + 
Sbjct: 991  QGFLKEGCELINEALNLFNNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLMS 1050

Query: 286  EKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNL 345
            E+ +G +HP       +LA+      +   A  L  RA  +   V G+DHP++A   NN+
Sbjct: 1051 ERVMGTEHPNTIQEYMHLALYCFASSQLSTALSLLYRARYLMLLVFGEDHPEMALLDNNI 1110

Query: 346  ALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKF-------K 398
             L+     +Y+    + + AL +     GP    VA + + +A  Y  + +F       K
Sbjct: 1111 GLVLHGVMEYDLSLRFLENALAVSTKYHGPKALKVALSHHLVARVYESKAEFRSALQHEK 1170

Query: 399  QAETLYKEILTRAHER 414
            +  T+YK  L   HE+
Sbjct: 1171 EGYTIYKTQLGEDHEK 1186



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 47/205 (22%), Positives = 86/205 (41%), Gaps = 8/205 (3%)

Query: 186  DPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEK 245
            D  + +  Q  +   + +  G E P  ++   +L +   +  +   A+ L  +A   +  
Sbjct: 1035 DYAEALSNQQKAVLMSERVMGTEHPNTIQEYMHLALYCFASSQLSTALSLLYRARYLMLL 1094

Query: 246  TSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAV 305
              G DHP++A + N + LV     +Y  +   L +ALA+  K  G     VA + + +A 
Sbjct: 1095 VFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTKYHGPKALKVALSHHLVAR 1154

Query: 306  LYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRA 365
            +Y  + +++ A    K    I +  LG+DH    +    L  L Q            QR 
Sbjct: 1155 VYESKAEFRSALQHEKEGYTIYKTQLGEDHEKTKESSEYLKCLTQQ-------AVALQRT 1207

Query: 366  L-EIYQTKLGPDDPNVAKTKNNLAS 389
            + EIY+     + P +  T  ++AS
Sbjct: 1208 MNEIYRNGSSANIPPLKFTAPSMAS 1232



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 43/167 (25%), Positives = 76/167 (45%), Gaps = 5/167 (2%)

Query: 227  GRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIRE 286
            G Y  A+   ++A+   E+  G +HP+       LAL     ++   A +LL  A  +  
Sbjct: 1034 GDYAEALSNQQKAVLMSERVMGTEHPNTIQEYMHLALYCFASSQLSTALSLLYRARYLML 1093

Query: 287  KTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLA 346
               G+DHP +A   NN+ ++     +Y  +    + AL +  K  G     VA   + +A
Sbjct: 1094 LVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTKYHGPKALKVALSHHLVA 1153

Query: 347  LLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLK 393
             + +++ ++     + +    IY+T+LG D     KTK   +S YLK
Sbjct: 1154 RVYESKAEFRSALQHEKEGYTIYKTQLGEDH---EKTKE--SSEYLK 1195



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 23/80 (28%), Positives = 35/80 (43%)

Query: 309  KRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEI 368
            ++G  KE   L   AL +   V G  H +    L  LA L    G Y E     Q+A+ +
Sbjct: 990  QQGFLKEGCELINEALNLFNNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLM 1049

Query: 369  YQTKLGPDDPNVAKTKNNLA 388
             +  +G + PN  +   +LA
Sbjct: 1050 SERVMGTEHPNTIQEYMHLA 1069


>gi|18104962 amyloid beta precursor protein-binding protein 2 [Homo
           sapiens]
          Length = 585

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 57/231 (24%), Positives = 109/231 (47%), Gaps = 18/231 (7%)

Query: 220 VIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRD-----------Q 268
           V QY+S G+++ A+   ++A+  +      DH  +A+   + AL+  +           Q
Sbjct: 342 VHQYSS-GKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQ 400

Query: 269 NKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIRE 328
              ++A +L   +L + +K  G+ +   A    NL  LY    K+KEAE +  +A++I+E
Sbjct: 401 RLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKE 460

Query: 329 KVLGKDHPDVAKQLNNLALLCQ-NQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNL 387
           ++LG++  +VA  + +LA L   +  +YE  E  Y R++ I +   G     +      L
Sbjct: 461 QLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGL 520

Query: 388 ASCYLKQGKFKQAETLYKEILT---RAHEREFGSVDDENKPIWMHAEEREE 435
              Y   G +++    Y  +L+   R  +R++ SV D  + +    +  EE
Sbjct: 521 IKLYNSIGNYEKVFE-YHNVLSNWNRLRDRQY-SVTDALEDVSTSPQSTEE 569



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 66/286 (23%), Positives = 112/286 (39%), Gaps = 19/286 (6%)

Query: 228 RYEVAVPLCKQALEDLEKTSGH-DHPDVATMLNILALVYRDQNKYKDAANLLNDALAIRE 286
           +Y +     K A   ++K S H    + A +   L  +   ++ Y +A     +A+  +E
Sbjct: 178 KYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAM--KE 235

Query: 287 KTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLA 346
            T G     V   L   +     + ++K+AE L K A+ +     G  HP  +  L +  
Sbjct: 236 ITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYG 295

Query: 347 LLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLA-SCYLKQ---GKFKQA-- 400
               N     +    YQ AL+I Q+  G  + +VA    +LA S Y+ Q   GKF  A  
Sbjct: 296 FYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALF 355

Query: 401 ----------ETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYG 450
                       L ++ L  A  +   ++  E   I  H +E E+   ++          
Sbjct: 356 HAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQ 415

Query: 451 GWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQ 496
              KA    +        NLG LY+   KF+ AE +   A++ ++Q
Sbjct: 416 LAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQ 461


>gi|22547159 tetratricopeptide repeat domain 19 [Homo sapiens]
          Length = 501

 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 37/146 (25%), Positives = 77/146 (52%), Gaps = 9/146 (6%)

Query: 268 QNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLA--VLYGKRGKYKEAEPLCKRALE 325
           + K +    L  D +++ EK     H  +   L+  A  +L+ K+    +A+ + ++AL+
Sbjct: 331 EEKIEREKELAEDIMSVEEKA--NTHLLLGMCLDACARYLLFSKQPS--QAQRMYEKALQ 386

Query: 326 IREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKN 385
           I E++ G+ HP     +++LA     QG+++E   Y QRA ++ +     + P +    +
Sbjct: 387 ISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQ---INHPELHMVLS 443

Query: 386 NLASCYLKQGKFKQAETLYKEILTRA 411
           NLA+  + + ++ QA+ +Y+E L +A
Sbjct: 444 NLAAVLMHRERYTQAKEIYQEALKQA 469


>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
          Length = 1036

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 47/157 (29%), Positives = 68/157 (43%), Gaps = 24/157 (15%)

Query: 252 PDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRG 311
           P+ A +   LA VY +Q     A +    A+ ++        P       NLA    ++G
Sbjct: 246 PNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ--------PHFPDAYCNLANALKEKG 297

Query: 312 KYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQT 371
              EAE     AL +         P  A  LNNLA + + QG  EE    Y++ALE++  
Sbjct: 298 SVAEAEDCYNTALRLC--------PTHADSLNNLANIKREQGNIEEAVRLYRKALEVF-- 347

Query: 372 KLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEIL 408
                 P  A   +NLAS   +QGK ++A   YKE +
Sbjct: 348 ------PEFAAAHSNLASVLQQQGKLQEALMHYKEAI 378



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 43/154 (27%), Positives = 70/154 (45%), Gaps = 24/154 (15%)

Query: 218 NLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANL 277
           NL   Y  QG  ++A+   ++A+E          P        LA   +++    +A + 
Sbjct: 254 NLACVYYEQGLIDLAIDTYRRAIEL--------QPHFPDAYCNLANALKEKGSVAEAEDC 305

Query: 278 LNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPD 337
            N AL +         P  A +LNNLA +  ++G  +EA  L ++ALE+         P+
Sbjct: 306 YNTALRLC--------PTHADSLNNLANIKREQGNIEEAVRLYRKALEV--------FPE 349

Query: 338 VAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQT 371
            A   +NLA + Q QGK +E   +Y+ A+ I  T
Sbjct: 350 FAAAHSNLASVLQQQGKLQEALMHYKEAIRISPT 383



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 49/181 (27%), Positives = 73/181 (40%), Gaps = 32/181 (17%)

Query: 210 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQN 269
           P    +L+NL      QG  E AV L ++ALE          P+ A   + LA V + Q 
Sbjct: 314 PTHADSLNNLANIKREQGNIEEAVRLYRKALEVF--------PEFAAAHSNLASVLQQQG 365

Query: 270 KYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREK 329
           K ++A     +A+ I         P  A   +N+     +    + A     RA++I   
Sbjct: 366 KLQEALMHYKEAIRI--------SPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQI--- 414

Query: 330 VLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLAS 389
                +P  A   +NLA + ++ G   E    Y+ AL     KL PD P+      NLA 
Sbjct: 415 -----NPAFADAHSNLASIHKDSGNIPEAIASYRTAL-----KLKPDFPD---AYCNLAH 461

Query: 390 C 390
           C
Sbjct: 462 C 462



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 27/114 (23%), Positives = 49/114 (42%), Gaps = 16/114 (14%)

Query: 291 KDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQ 350
           K +P +A   +NL  +Y +RG+ +EA    + AL ++        PD      NLA    
Sbjct: 73  KQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLK--------PDFIDGYINLAAALV 124

Query: 351 NQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLY 404
             G  E     Y  AL+         +P++   +++L +     G+ ++A+  Y
Sbjct: 125 AAGDMEGAVQAYVSALQY--------NPDLYCVRSDLGNLLKALGRLEEAKACY 170



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 53/213 (24%), Positives = 75/213 (35%), Gaps = 34/213 (15%)

Query: 287 KTLGKDHPAVAATLN------NLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAK 340
           K LG+   A A  L       N AV +   G    A+     A+   EK +  D P+   
Sbjct: 158 KALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLD-PNFLD 216

Query: 341 QLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQA 400
              NL  + +    ++     Y RAL +         PN A    NLA  Y +QG    A
Sbjct: 217 AYINLGNVLKEARIFDRAVAAYLRALSL--------SPNHAVVHGNLACVYYEQGLIDLA 268

Query: 401 ETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGE--YGGWYKACKV 458
              Y+  +             E +P +  A        K+K   +  E  Y    + C  
Sbjct: 269 IDTYRRAI-------------ELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLC-- 313

Query: 459 DSPTVTTTLKNLGALYRRQGKFEAAETLEEAAM 491
             PT   +L NL  + R QG  E A  L   A+
Sbjct: 314 --PTHADSLNNLANIKREQGNIEEAVRLYRKAL 344


>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
          Length = 1046

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 47/157 (29%), Positives = 68/157 (43%), Gaps = 24/157 (15%)

Query: 252 PDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRG 311
           P+ A +   LA VY +Q     A +    A+ ++        P       NLA    ++G
Sbjct: 256 PNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ--------PHFPDAYCNLANALKEKG 307

Query: 312 KYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQT 371
              EAE     AL +         P  A  LNNLA + + QG  EE    Y++ALE++  
Sbjct: 308 SVAEAEDCYNTALRLC--------PTHADSLNNLANIKREQGNIEEAVRLYRKALEVF-- 357

Query: 372 KLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEIL 408
                 P  A   +NLAS   +QGK ++A   YKE +
Sbjct: 358 ------PEFAAAHSNLASVLQQQGKLQEALMHYKEAI 388



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 43/154 (27%), Positives = 70/154 (45%), Gaps = 24/154 (15%)

Query: 218 NLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANL 277
           NL   Y  QG  ++A+   ++A+E          P        LA   +++    +A + 
Sbjct: 264 NLACVYYEQGLIDLAIDTYRRAIEL--------QPHFPDAYCNLANALKEKGSVAEAEDC 315

Query: 278 LNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPD 337
            N AL +         P  A +LNNLA +  ++G  +EA  L ++ALE+         P+
Sbjct: 316 YNTALRLC--------PTHADSLNNLANIKREQGNIEEAVRLYRKALEV--------FPE 359

Query: 338 VAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQT 371
            A   +NLA + Q QGK +E   +Y+ A+ I  T
Sbjct: 360 FAAAHSNLASVLQQQGKLQEALMHYKEAIRISPT 393



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 49/181 (27%), Positives = 73/181 (40%), Gaps = 32/181 (17%)

Query: 210 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQN 269
           P    +L+NL      QG  E AV L ++ALE          P+ A   + LA V + Q 
Sbjct: 324 PTHADSLNNLANIKREQGNIEEAVRLYRKALEVF--------PEFAAAHSNLASVLQQQG 375

Query: 270 KYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREK 329
           K ++A     +A+ I         P  A   +N+     +    + A     RA++I   
Sbjct: 376 KLQEALMHYKEAIRI--------SPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQI--- 424

Query: 330 VLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLAS 389
                +P  A   +NLA + ++ G   E    Y+ AL     KL PD P+      NLA 
Sbjct: 425 -----NPAFADAHSNLASIHKDSGNIPEAIASYRTAL-----KLKPDFPD---AYCNLAH 471

Query: 390 C 390
           C
Sbjct: 472 C 472



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 27/114 (23%), Positives = 49/114 (42%), Gaps = 16/114 (14%)

Query: 291 KDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQ 350
           K +P +A   +NL  +Y +RG+ +EA    + AL ++        PD      NLA    
Sbjct: 83  KQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLK--------PDFIDGYINLAAALV 134

Query: 351 NQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLY 404
             G  E     Y  AL+         +P++   +++L +     G+ ++A+  Y
Sbjct: 135 AAGDMEGAVQAYVSALQY--------NPDLYCVRSDLGNLLKALGRLEEAKACY 180



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 53/213 (24%), Positives = 75/213 (35%), Gaps = 34/213 (15%)

Query: 287 KTLGKDHPAVAATLN------NLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAK 340
           K LG+   A A  L       N AV +   G    A+     A+   EK +  D P+   
Sbjct: 168 KALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLD-PNFLD 226

Query: 341 QLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQA 400
              NL  + +    ++     Y RAL +         PN A    NLA  Y +QG    A
Sbjct: 227 AYINLGNVLKEARIFDRAVAAYLRALSL--------SPNHAVVHGNLACVYYEQGLIDLA 278

Query: 401 ETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGE--YGGWYKACKV 458
              Y+  +             E +P +  A        K+K   +  E  Y    + C  
Sbjct: 279 IDTYRRAI-------------ELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLC-- 323

Query: 459 DSPTVTTTLKNLGALYRRQGKFEAAETLEEAAM 491
             PT   +L NL  + R QG  E A  L   A+
Sbjct: 324 --PTHADSLNNLANIKREQGNIEEAVRLYRKAL 354


>gi|224586823 coiled-coil domain containing 110 isoform b [Homo
           sapiens]
          Length = 796

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 47/185 (25%), Positives = 89/185 (48%), Gaps = 9/185 (4%)

Query: 11  IKEDKLE--KLTQDEIISKTKQ--VIQGLEALKNEHNSILQSLLETLKC--LKKDDESNL 64
           +KE +LE  +L + E ++KT+Q  ++Q +E +K+E  ++  +L E+     + + +  N+
Sbjct: 569 LKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENI 628

Query: 65  VEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDEL 124
              +S      L+ ++   SEA +     N L+ +  E + L   V     +NQ L++EL
Sbjct: 629 QTYQSTAEENFLQEIKNAKSEASIY---KNSLSEIGKECEMLSKMVMETKTDNQILKEEL 685

Query: 125 ANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDE 184
               Q+  K E S+++L E+K  LE   +  + + D    E +        L D   N  
Sbjct: 686 KKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQH 745

Query: 185 DDPGQ 189
           +DP +
Sbjct: 746 NDPSK 750



 Score = 37.0 bits (84), Expect = 0.054
 Identities = 37/174 (21%), Positives = 82/174 (47%), Gaps = 20/174 (11%)

Query: 12  KEDKLEKLTQDEIISKTKQVIQGLEALKNEHN--SILQSLLETLKCLKKDDESNLVEEKS 69
           K+  +E L  D++ SK  +    +  + NE+N  SI    ++T   L   DE  ++E+K+
Sbjct: 499 KQQMMEAL--DQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKT-NILLIQDEKEMLEKKT 555

Query: 70  NMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQ 129
           + + K    L   L E+Q+       +  ++ +++  + +   L Q  + ++DE  N + 
Sbjct: 556 HQLLKEKSSLGNELKESQL------EIIQLKEKERLAKTEQETLLQIIETVKDEKLNLET 609

Query: 130 KLQKSEQSVAQLEEEKKHLE---------FMNQLKKYDDDISPSEDKDTDSTKE 174
            LQ+S  +   +E E ++++         F+ ++K    + S  ++  ++  KE
Sbjct: 610 TLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKE 663



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 24/110 (21%), Positives = 50/110 (45%), Gaps = 1/110 (0%)

Query: 47  QSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKL 106
           QSL++ ++  +K  + NLVEEKS +  K  +  E      +    + +  N ++ + + L
Sbjct: 430 QSLIQKVETYEKQLK-NLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTL 488

Query: 107 RAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKK 156
             +  +L  E Q + + L   + K  K++  +A +  E   +    +  K
Sbjct: 489 EEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMK 538


>gi|22749515 coiled-coil domain containing 110 isoform a [Homo
           sapiens]
          Length = 833

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 47/185 (25%), Positives = 89/185 (48%), Gaps = 9/185 (4%)

Query: 11  IKEDKLE--KLTQDEIISKTKQ--VIQGLEALKNEHNSILQSLLETLKC--LKKDDESNL 64
           +KE +LE  +L + E ++KT+Q  ++Q +E +K+E  ++  +L E+     + + +  N+
Sbjct: 606 LKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENI 665

Query: 65  VEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDEL 124
              +S      L+ ++   SEA +     N L+ +  E + L   V     +NQ L++EL
Sbjct: 666 QTYQSTAEENFLQEIKNAKSEASIY---KNSLSEIGKECEMLSKMVMETKTDNQILKEEL 722

Query: 125 ANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDE 184
               Q+  K E S+++L E+K  LE   +  + + D    E +        L D   N  
Sbjct: 723 KKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQH 782

Query: 185 DDPGQ 189
           +DP +
Sbjct: 783 NDPSK 787



 Score = 37.0 bits (84), Expect = 0.054
 Identities = 37/174 (21%), Positives = 82/174 (47%), Gaps = 20/174 (11%)

Query: 12  KEDKLEKLTQDEIISKTKQVIQGLEALKNEHN--SILQSLLETLKCLKKDDESNLVEEKS 69
           K+  +E L  D++ SK  +    +  + NE+N  SI    ++T   L   DE  ++E+K+
Sbjct: 536 KQQMMEAL--DQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKT-NILLIQDEKEMLEKKT 592

Query: 70  NMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQ 129
           + + K    L   L E+Q+       +  ++ +++  + +   L Q  + ++DE  N + 
Sbjct: 593 HQLLKEKSSLGNELKESQL------EIIQLKEKERLAKTEQETLLQIIETVKDEKLNLET 646

Query: 130 KLQKSEQSVAQLEEEKKHLE---------FMNQLKKYDDDISPSEDKDTDSTKE 174
            LQ+S  +   +E E ++++         F+ ++K    + S  ++  ++  KE
Sbjct: 647 TLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKE 700



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 24/110 (21%), Positives = 50/110 (45%), Gaps = 1/110 (0%)

Query: 47  QSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKL 106
           QSL++ ++  +K  + NLVEEKS +  K  +  E      +    + +  N ++ + + L
Sbjct: 467 QSLIQKVETYEKQLK-NLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTL 525

Query: 107 RAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKK 156
             +  +L  E Q + + L   + K  K++  +A +  E   +    +  K
Sbjct: 526 EEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMK 575


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 89/451 (19%), Positives = 191/451 (42%), Gaps = 52/451 (11%)

Query: 1    MYDNMSTMVYIKEDKLEKLTQ----------DEIISKTKQVIQGLEAL--KNEHNSILQS 48
            + +N+S +  +KE  LEK  Q          +E +S  + + + +  L  K E  ++L S
Sbjct: 789  LQENLSEVSQVKET-LEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSS 847

Query: 49   LLETL---------KCLKKDD-ESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNA 98
             LE L         K  +KD+ E  L++ K  +     E++++    +  +  +++ L  
Sbjct: 848  DLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL 907

Query: 99   VESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQL-EEEKKHLE-FMNQLKK 156
             E + ++L+ ++ +  +   +L+  + +   K ++S+Q  A+  EEEKK LE  ++ L+K
Sbjct: 908  KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEK 967

Query: 157  YDD-------DISPSEDKDTDSTKEPLDDLFPN------DEDDPGQGIQQQHSSAAAAAQ 203
              +       ++    ++ T  TK   +++  N      D +D  +G ++++S      +
Sbjct: 968  KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELE 1027

Query: 204  QGGYEI-PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILA 262
            +   +   A+        +Q   Q   E    L   +LED ++T+     ++ T+     
Sbjct: 1028 ELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLA--SLEDTKQTNAKLQNELDTLKENNL 1085

Query: 263  LVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKR 322
                + NK K+   + N  +    K +     A A     L+ L  +    K AE L + 
Sbjct: 1086 KNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSAL--QEENVKLAEELGRS 1143

Query: 323  ALEIREKVLGKDHPDVAKQLNNLALLCQNQGKY----EEVEYYYQRALEIYQTKLGPDDP 378
              E+      ++   V    N L  + + + K+    +E +   Q+++ I    L   D 
Sbjct: 1144 RDEVTSHQKLEEERSVLN--NQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDA 1201

Query: 379  NVAKTKNNLASCYLKQGKFKQAETLYKEILT 409
             + K +N +    + +G+   A++L+  + T
Sbjct: 1202 ELEKLRNEVT---VLRGENASAKSLHSVVQT 1229



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 104/578 (17%), Positives = 220/578 (38%), Gaps = 54/578 (9%)

Query: 46   LQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQK 105
            L++ +E ++   + +  NL  ++ +   ++    E+    A++M  +    N++E+ + K
Sbjct: 613  LKTQIEKMRLDYQHEIENLQNQQDS--ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSK 670

Query: 106  L-RAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEE-EKKHLEFMNQLKKYDDDISP 163
            L +A+ + L         E+ +T  KLQ++E  V +LE  + K  E    +  +   +  
Sbjct: 671  LDKAEDQHLV--------EMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA 722

Query: 164  SEDKDTDSTKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQY 223
            +E+K  D     LD L     +   +  + +    AA  Q    EI     +     I  
Sbjct: 723  TEEKLLD-----LDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 777

Query: 224  ASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALA 283
              QGR E+ +   ++ L ++ +        +   L IL      + K+ +A+        
Sbjct: 778  ELQGR-ELKLTNLQENLSEVSQVK----ETLEKELQIL------KEKFAEASEEAVSVQR 826

Query: 284  IREKTLGKDHP------AVAATLNNLAV-LYGKRGKYKEAEPLCKRALEIREKVLGKDHP 336
              ++T+ K H        +++ L  L   L     K++E +   ++ ++ +EK+      
Sbjct: 827  SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL----EN 882

Query: 337  DVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGK 396
            D+A+ +           K  +     +R +E  Q KL   + N +  + ++    +K  +
Sbjct: 883  DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ 942

Query: 397  FKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKAC 456
             +Q      E   +  ER+   + D  K +     + +E K + +  TS  +        
Sbjct: 943  SQQEAAKKHEEEKKELERK---LSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ 999

Query: 457  KVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENM 516
             +    + T  K  GA     G  +  E L + A +++         Q   + +   E M
Sbjct: 1000 NLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKA-------AQTAEDAMQIMEQM 1052

Query: 517  EKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGDGTGSLKRSGSFSKLRASIRRSSEKL 576
             K ++    +++  K ++      E+    E N      L +S     +         K 
Sbjct: 1053 TKEKTETLASLEDTK-QTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKE 1111

Query: 577  VRKLKGGSSRESEP----KNPGASLAEPLFVENDSSSS 610
            +  LK  ++++S+     +     LAE L    D  +S
Sbjct: 1112 IETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTS 1149


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 89/451 (19%), Positives = 191/451 (42%), Gaps = 52/451 (11%)

Query: 1    MYDNMSTMVYIKEDKLEKLTQ----------DEIISKTKQVIQGLEAL--KNEHNSILQS 48
            + +N+S +  +KE  LEK  Q          +E +S  + + + +  L  K E  ++L S
Sbjct: 824  LQENLSEVSQVKET-LEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSS 882

Query: 49   LLETL---------KCLKKDD-ESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNA 98
             LE L         K  +KD+ E  L++ K  +     E++++    +  +  +++ L  
Sbjct: 883  DLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL 942

Query: 99   VESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQL-EEEKKHLE-FMNQLKK 156
             E + ++L+ ++ +  +   +L+  + +   K ++S+Q  A+  EEEKK LE  ++ L+K
Sbjct: 943  KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEK 1002

Query: 157  YDD-------DISPSEDKDTDSTKEPLDDLFPN------DEDDPGQGIQQQHSSAAAAAQ 203
              +       ++    ++ T  TK   +++  N      D +D  +G ++++S      +
Sbjct: 1003 KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELE 1062

Query: 204  QGGYEI-PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILA 262
            +   +   A+        +Q   Q   E    L   +LED ++T+     ++ T+     
Sbjct: 1063 ELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLA--SLEDTKQTNAKLQNELDTLKENNL 1120

Query: 263  LVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKR 322
                + NK K+   + N  +    K +     A A     L+ L  +    K AE L + 
Sbjct: 1121 KNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSAL--QEENVKLAEELGRS 1178

Query: 323  ALEIREKVLGKDHPDVAKQLNNLALLCQNQGKY----EEVEYYYQRALEIYQTKLGPDDP 378
              E+      ++   V    N L  + + + K+    +E +   Q+++ I    L   D 
Sbjct: 1179 RDEVTSHQKLEEERSVLN--NQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDA 1236

Query: 379  NVAKTKNNLASCYLKQGKFKQAETLYKEILT 409
             + K +N +    + +G+   A++L+  + T
Sbjct: 1237 ELEKLRNEVT---VLRGENASAKSLHSVVQT 1264



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 104/578 (17%), Positives = 220/578 (38%), Gaps = 54/578 (9%)

Query: 46   LQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQK 105
            L++ +E ++   + +  NL  ++ +   ++    E+    A++M  +    N++E+ + K
Sbjct: 648  LKTQIEKMRLDYQHEIENLQNQQDS--ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSK 705

Query: 106  L-RAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEE-EKKHLEFMNQLKKYDDDISP 163
            L +A+ + L         E+ +T  KLQ++E  V +LE  + K  E    +  +   +  
Sbjct: 706  LDKAEDQHLV--------EMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA 757

Query: 164  SEDKDTDSTKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQY 223
            +E+K  D     LD L     +   +  + +    AA  Q    EI     +     I  
Sbjct: 758  TEEKLLD-----LDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 812

Query: 224  ASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALA 283
              QGR E+ +   ++ L ++ +        +   L IL      + K+ +A+        
Sbjct: 813  ELQGR-ELKLTNLQENLSEVSQVK----ETLEKELQIL------KEKFAEASEEAVSVQR 861

Query: 284  IREKTLGKDHP------AVAATLNNLAV-LYGKRGKYKEAEPLCKRALEIREKVLGKDHP 336
              ++T+ K H        +++ L  L   L     K++E +   ++ ++ +EK+      
Sbjct: 862  SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL----EN 917

Query: 337  DVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGK 396
            D+A+ +           K  +     +R +E  Q KL   + N +  + ++    +K  +
Sbjct: 918  DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ 977

Query: 397  FKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKAC 456
             +Q      E   +  ER+   + D  K +     + +E K + +  TS  +        
Sbjct: 978  SQQEAAKKHEEEKKELERK---LSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ 1034

Query: 457  KVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENM 516
             +    + T  K  GA     G  +  E L + A +++         Q   + +   E M
Sbjct: 1035 NLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKA-------AQTAEDAMQIMEQM 1087

Query: 517  EKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGDGTGSLKRSGSFSKLRASIRRSSEKL 576
             K ++    +++  K ++      E+    E N      L +S     +         K 
Sbjct: 1088 TKEKTETLASLEDTK-QTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKE 1146

Query: 577  VRKLKGGSSRESEP----KNPGASLAEPLFVENDSSSS 610
            +  LK  ++++S+     +     LAE L    D  +S
Sbjct: 1147 IETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTS 1184


>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
           [Homo sapiens]
          Length = 774

 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 47/165 (28%), Positives = 73/165 (44%), Gaps = 24/165 (14%)

Query: 251 HPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKR 310
           HP     L  L  + + Q K ++A  LL D++        K  P  A   ++LA L  ++
Sbjct: 436 HPQHNRALFNLGNLLKSQEKKEEAITLLKDSI--------KYGPEFADAYSSLASLLAEQ 487

Query: 311 GKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQ 370
            ++KEAE + +  +        K+ PD +   NN  +   + G  E+   +YQ+A+    
Sbjct: 488 ERFKEAEEIYQTGI--------KNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAI---- 535

Query: 371 TKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHERE 415
            KL P   +VA    NL   Y   G+   AE  YK  L  AH+ E
Sbjct: 536 -KLSPSH-HVAMV--NLGRLYRSLGENSMAEEWYKRALQVAHKAE 576



 Score = 37.4 bits (85), Expect = 0.041
 Identities = 44/207 (21%), Positives = 82/207 (39%), Gaps = 46/207 (22%)

Query: 208 EIPARLRTLHNLVIQYASQGRYEVAVPLCKQAL-----------------------EDLE 244
           ++  +   L  L   Y + GRYE A+ + ++A                        ++ E
Sbjct: 570 QVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAE 629

Query: 245 KTSGH---DHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLN 301
           K + H   +         +L+ +Y  Q  +  A + ++ AL ++ K      P V     
Sbjct: 630 KMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKD-----PKV----- 679

Query: 302 NLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYY 361
            ++ L+  +G     + L  +A E   +V  + +PD A+   N+  +   +GKY     Y
Sbjct: 680 -ISELFFTKGNQLREQNLLDKAFE-SYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAY 737

Query: 362 YQRALEIYQTKLGPDDPNVAKTKNNLA 388
           Y+RAL++         P+    K NLA
Sbjct: 738 YERALQLV--------PDSKLLKENLA 756



 Score = 33.5 bits (75), Expect = 0.60
 Identities = 36/160 (22%), Positives = 64/160 (40%), Gaps = 30/160 (18%)

Query: 336 PDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQG 395
           P  AK   N A   ++QG+ +E  Y+Y+ AL++Y        P  A   NNL +      
Sbjct: 372 PHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLY--------PRHASALNNLGTLTRDTA 423

Query: 396 KFKQAETLYKEILT--RAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWY 453
              +A+  Y+  L     H R   ++ +    +    E++EE     KD   +G      
Sbjct: 424 ---EAKMYYQRALQLHPQHNRALFNLGN----LLKSQEKKEEAITLLKDSIKYG------ 470

Query: 454 KACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRS 493
                  P       +L +L   Q +F+ AE + +  +++
Sbjct: 471 -------PEFADAYSSLASLLAEQERFKEAEEIYQTGIKN 503


>gi|110815815 centlein isoform 1 [Homo sapiens]
          Length = 1406

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 60/286 (20%), Positives = 125/286 (43%), Gaps = 33/286 (11%)

Query: 18  KLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETL-KCLKKDDESNLVE-------EKS 69
           K    E++ +   + + L+ LK  H SI ++ ++ L +C+ +  E  L         ++S
Sbjct: 619 KRENQELMIQKMNLEEELDELK-VHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRS 677

Query: 70  NMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQ 129
              +   EMLE  L   Q +  L N L + E   +KL+   ++L +EN +L+  L   Q+
Sbjct: 678 TPEKNGKEMLEQTL---QKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQE 734

Query: 130 KLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLD-DLFPNDEDDPG 188
             +  E+ + Q+ +  K +E  N   +    IS  E + T   ++  + +   N+ ++  
Sbjct: 735 DTETREKELEQIIKGSKDVEKEN--TELQVKISELETEVTSLRRQVAEANALRNENEELI 792

Query: 189 QGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEK--T 246
             +++ H SA  A  +              +       GRY+    + K   +  +K  +
Sbjct: 793 NPMEKSHQSADRAKSE--------------MATMKVRSGRYDCKTTMTKVKFKAAKKNCS 838

Query: 247 SGHDHPDVATMLNILALVYRDQNK--YKDAANLLNDALAIREKTLG 290
            G  H  +   + +++ V+ + +K  ++D +   +D+ A   +TLG
Sbjct: 839 VGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLG 884



 Score = 31.2 bits (69), Expect = 3.0
 Identities = 38/156 (24%), Positives = 63/156 (40%), Gaps = 19/156 (12%)

Query: 32  IQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMMA 91
           +  LE L     S ++ L E LK   +    N+   K    +  +   E    E  V  +
Sbjct: 454 LSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRS 513

Query: 92  --LSNHLNAVESEK-QKLRAQVRRL----------CQENQWLRDELANTQQKLQKSEQSV 138
             LS   +  +SE+ QKLR   R++           QEN  LRD     +++LQ  + + 
Sbjct: 514 RSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNY 573

Query: 139 AQLEEEKKHLE------FMNQLKKYDDDISPSEDKD 168
             ++E+ K  E       + ++K+ D      ED D
Sbjct: 574 RAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSD 609



 Score = 30.4 bits (67), Expect = 5.0
 Identities = 40/155 (25%), Positives = 75/155 (48%), Gaps = 19/155 (12%)

Query: 15  KLEKLTQDE-IISKTKQVIQGLEALKNE------HNSILQSLLETLKCLKKDDE---SNL 64
           +LE ++ +E ++++T+ + + L +LK E          + SL + L+    D     S +
Sbjct: 88  RLEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLV 147

Query: 65  VE-EKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESE-KQKLRAQVRR---LCQENQW 119
           VE EK     K  ++LE+     QV  A        ES  KQ++   V+R   + +EN +
Sbjct: 148 VEREKQKSEAKDRKVLEI----LQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAF 203

Query: 120 LRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQL 154
           LR E ++ ++K +   Q +   +E  ++ E  N+L
Sbjct: 204 LRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRL 238



 Score = 30.4 bits (67), Expect = 5.0
 Identities = 20/97 (20%), Positives = 48/97 (49%), Gaps = 4/97 (4%)

Query: 65  VEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDEL 124
           V+E++  +RK    LE    +      + +    V++++++ R  ++ L +EN+ L    
Sbjct: 197 VDEENAFLRKEFSDLEKKFKDKS--QEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRC 254

Query: 125 ANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDI 161
            +    L+K  +  A L +EK   +   ++K ++D++
Sbjct: 255 TDLLNDLEKLRKQEAHLRKEKYSTD--AKIKTFEDNL 289


>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
           protein) [Homo sapiens]
          Length = 543

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 46/191 (24%), Positives = 79/191 (41%), Gaps = 33/191 (17%)

Query: 210 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQN 269
           P  +  + N    Y  +G Y     LC++A+E + + +  D+  +A     +   Y  + 
Sbjct: 256 PTNMTYITNQAAVYFEKGDYNKCRELCEKAIE-VGRENREDYRQIAKAYARIGNSYFKEE 314

Query: 270 KYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREK 329
           KYKDA +  N +LA          P V               K ++AE + K      ++
Sbjct: 315 KYKDAIHFYNKSLAEHRT------PDVLK-------------KCQQAEKILK-----EQE 350

Query: 330 VLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLAS 389
            L   +PD+A +  N    C  +G Y +   +Y  A++         +P  AK  +N A+
Sbjct: 351 RLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIK--------RNPKDAKLYSNRAA 402

Query: 390 CYLKQGKFKQA 400
           CY K  +F+ A
Sbjct: 403 CYTKLLEFQLA 413



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 37/171 (21%), Positives = 71/171 (41%), Gaps = 41/171 (23%)

Query: 279 NDALAIREKTLGKD--------------------HPAVAATLNNLAVLYGKRGKYKEAEP 318
           N   A++EK LG D                     P     + N A +Y ++G Y +   
Sbjct: 221 NKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRE 280

Query: 319 LCKRALEI-REKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQT------ 371
           LC++A+E+ RE    +D+  +AK    +      + KY++  ++Y ++L  ++T      
Sbjct: 281 LCEKAIEVGREN--REDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKK 338

Query: 372 ------------KLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTR 410
                       +L   +P++A  + N  +   ++G + QA   Y E + R
Sbjct: 339 CQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKR 389


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin
           (with transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 109/585 (18%), Positives = 229/585 (39%), Gaps = 64/585 (10%)

Query: 7   TMVYIKEDKLEKL-TQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLV 65
           T V + ED+L +L TQ ++ ++ +Q ++ L+    EH   L    + +  L++  E    
Sbjct: 228 TQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQ--ELTAA 285

Query: 66  EEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELA 125
           E+++ ++ + L+ +E   +  +  +      + +  EK +L    R+L   N  L++E+ 
Sbjct: 286 EQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHN--LQEEMH 343

Query: 126 NTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDED 185
           +  ++ +++ Q+ A+LE     LE   Q  K + +   S       T + L       +D
Sbjct: 344 HLLEQFEQAGQAQAELESRYSALE---QKHKAEMEEKTSHILSLQKTGQELQSACDALKD 400

Query: 186 DPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEK 245
              + +Q ++  A  +AQ           T+  L  Q   + + E++  L +  L+  E 
Sbjct: 401 QNSKLLQDKNEQAVQSAQ-----------TIQQLEDQLQQKSK-EISQFLNRLPLQQHET 448

Query: 246 TSGHDHPDV-------ATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAA 298
            S    PDV        T  NI +L  R      +   LL  ++ + E     +  +   
Sbjct: 449 ASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQI 508

Query: 299 TLNNLAVLYGKRGKYKE-------AEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQN 351
           TL       G+  +          A      A E  + VL        K+L+   LL + 
Sbjct: 509 TLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELS--VLLLEM 566

Query: 352 QGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRA 411
           +   EE+ +     L++   +    D  V   K       +KQ + +    +  ++    
Sbjct: 567 KEAQEEIAFL---KLQLQGKRAEEADHEVLDQKE------MKQMEGEGIAPIKMKVFLED 617

Query: 412 HEREFGSVDDENKPIWMHAEEREECKGKQKDGT----SFGEYGGWYKACKVDSPTVTTTL 467
             ++F  + +E     + A E+E+   + +  T    S  + G   K+ K D     + +
Sbjct: 618 TGQDFPLMPNEESS--LPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAV 675

Query: 468 KNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNV 527
            ++G  ++ + +   ++ LE            N HK   A+ + +    EK +   +LN 
Sbjct: 676 PDIGQCHQDELERLKSQILELEL---------NFHK---AQEIYEKNLDEKAKEISNLNQ 723

Query: 528 DVVKYESGPDGGEEVSMSVEWNGDG-TGSLKRSGSFSKLRASIRR 571
            + +++   D       ++    D     +K     ++LRA +++
Sbjct: 724 LIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQ 768



 Score = 37.0 bits (84), Expect = 0.054
 Identities = 38/184 (20%), Positives = 78/184 (42%), Gaps = 29/184 (15%)

Query: 12   KEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNM 71
            KE ++   + + + ++ +++   +EA++ E   +   L  T +  KK+ E  L E +  M
Sbjct: 1613 KEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRST-EANKKETEKQLQEAEQEM 1671

Query: 72   IRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVR-----------RLCQENQWL 120
                 +M +   S+ Q ++ L       E E  +LRA+V             L   N  +
Sbjct: 1672 EEMKEKMRKFAKSKQQKILEL-------EEENDRLRAEVHPAGDTAKECMETLLSSNASM 1724

Query: 121  RDELANTQ----------QKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTD 170
            ++EL   +          Q L   + S+++  ++ KH    N  K+ + + +   D  T+
Sbjct: 1725 KEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTN 1784

Query: 171  STKE 174
             T+E
Sbjct: 1785 VTEE 1788



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 13/129 (10%)

Query: 38   LKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLN 97
            L +  +   + L + LK LKK+ +SN    KS M +K  E LE  L +A+       HL 
Sbjct: 2084 LDDTQSEAARVLADNLK-LKKELQSNKESVKSQMKQKD-EDLERRLEQAE-----EKHLK 2136

Query: 98   AVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKY 157
                EK+ ++ ++  L +E   L + +   Q  L K ++ V QL+E       + QL  +
Sbjct: 2137 ----EKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLD--STVTQLAAF 2190

Query: 158  DDDISPSED 166
               +S  +D
Sbjct: 2191 TKSMSSLQD 2199



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 39/150 (26%), Positives = 72/150 (48%), Gaps = 16/150 (10%)

Query: 9    VYIKEDKLEKLTQDEIISKTKQVIQGLEALKN--EHNSILQSLLETLKCLKKDDESNLVE 66
            V ++ + L K  Q  ++S+   + + ++ LK+  E N   Q+ LE  +  K D+++N+ E
Sbjct: 1731 VKMEYETLSKKFQS-LMSEKDSLSEEVQDLKHQIEGNVSKQANLEATE--KHDNQTNVTE 1787

Query: 67   EKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELAN 126
            E +  I         G +E Q  +++S      ES      A       ++    DE+ N
Sbjct: 1788 EGTQSIP--------GETEEQDSLSMSTRPTCSESVPSAKSANPA--VSKDFSSHDEINN 1837

Query: 127  TQQKLQKSEQSVAQLEEEK-KHLEFMNQLK 155
              Q++ + ++ +A LEEEK K+ EF   L+
Sbjct: 1838 YLQQIDQLKERIAGLEEEKQKNKEFSQTLE 1867



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 31/137 (22%), Positives = 63/137 (45%), Gaps = 2/137 (1%)

Query: 26   SKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSE 85
            +K K+ I+GL +  ++ NS   + L+      ++D + ++  K +  ++ LE+      E
Sbjct: 2506 NKLKEEIRGLRSHMDDLNSE-NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKE 2564

Query: 86   AQVMMA-LSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEE 144
             +   A L   L   E   + LR     L +E Q L  E+ + +  + +  + V  L+EE
Sbjct: 2565 LENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEE 2624

Query: 145  KKHLEFMNQLKKYDDDI 161
                 +  QLK  ++++
Sbjct: 2625 GTLGLYHAQLKVKEEEV 2641


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 45/161 (27%), Positives = 81/161 (50%), Gaps = 12/161 (7%)

Query: 7    TMVYIKEDKLEKLTQDEIISKTKQVI----QGLEALKNEHNSIL---QSLLETLKCLKKD 59
            T V + E+KLE     +I  + K  I    Q LE  K E   +    ++L   ++CL K+
Sbjct: 1729 TQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKE 1788

Query: 60   DESNLVEEKSNMIRKSLEMLE--LGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQEN 117
             E   ++EK ++  K L   +  L  +E    M  SN L  +E   +KL+ ++ +L ++ 
Sbjct: 1789 KED--LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSN-LEKLELNVRKLQQELDQLNRDK 1845

Query: 118  QWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYD 158
              L ++++  QQ+LQ+  ++V  L+EE  +++    L K D
Sbjct: 1846 LSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQD 1886



 Score = 38.5 bits (88), Expect = 0.018
 Identities = 38/157 (24%), Positives = 80/157 (50%), Gaps = 23/157 (14%)

Query: 29   KQVIQGLEALKNEHNSILQSLLETLK---CLKKDDES-NLV----EEKSNMIRKSLEMLE 80
            KQV    EALK + + + ++LLE  +   C++K+  +  LV     E++  + K L  ++
Sbjct: 2071 KQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQ 2130

Query: 81   LGLSEAQVMMA-----------LSNHLNAVESE-KQKLRAQVRRLCQENQWLRDELANTQ 128
               +E +  MA           +S+ +  ++SE K ++R  ++ L   NQ+L +  A+ +
Sbjct: 2131 YEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNL---NQFLPELPADLE 2187

Query: 129  QKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSE 165
              L+++E    +LE  K++L F      +++ ++ S+
Sbjct: 2188 AILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQ 2224



 Score = 37.7 bits (86), Expect = 0.032
 Identities = 128/618 (20%), Positives = 237/618 (38%), Gaps = 92/618 (14%)

Query: 13   EDKLEKLTQDEIISKTKQV------IQGLEALKNEHNSIL------QSLLETLKCLKKDD 60
            E ++EK  Q EI  K K++      I  L++   +H+ +       +  L+ +    +  
Sbjct: 516  ELQMEKQKQ-EIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL 574

Query: 61   ESNLVEEKSNMIRKSLEM--LELGLSEAQVMM--ALSNHLNAVESEKQK----LRAQVRR 112
            ES L E  S + +++ E+  LE  L+E Q+    AL   L  V S  Q+    ++ Q  +
Sbjct: 575  ESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQ 634

Query: 113  LCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDST 172
               E + LRDE     Q+L + EQ   QLE      E M +     +     + +   S 
Sbjct: 635  AQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASL 694

Query: 173  KEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVA 232
            ++   DL   + +     ++ + +   A A Q   E+    R     + Q A Q   E  
Sbjct: 695  QQTQGDLSAYEAE-----LEARLNLRDAEANQLKEELEKVTRLTQ--LEQSALQAELEKE 747

Query: 233  VPLCKQAL------EDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIRE 286
                K AL      E+ E+ +   H  +  + +   L+ +    +++  N + D L   E
Sbjct: 748  RQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPE 807

Query: 287  KTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLA 346
            +        VAA ++ L      R K K      +  +     VLGK   D+ KQ +   
Sbjct: 808  E--------VAARVDEL------RRKLKLGTG--EMNIHSPSDVLGKSLADLQKQFSE-- 849

Query: 347  LLCQNQGKYEEV---EYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETL 403
            +L +++ + +E    E   Q  + + Q KL        +         +   K +Q E  
Sbjct: 850  ILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDK-RQHEAR 908

Query: 404  YKEILTRAH----------------EREFGSVDDENKPIWMHAEEREECKGKQKDGTSFG 447
             +++    H                + +    D+E + I     E E+ K K +D  S  
Sbjct: 909  IQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK-KKKLEDAKSQE 967

Query: 448  EYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAE-TLEEAAMRSRKQGLDNVHKQRV 506
            +  G  K  K     V T+            K   AE T+ +  ++S    +  ++++R 
Sbjct: 968  QVFGLDKELKKLKKAVATS-----------DKLATAELTIAKDQLKSLHGTVMKINQER- 1015

Query: 507  AEVLNDPENMEKRRSRESLNVDVVKYESG------PDGGEEVSMSVEWNGDGTGSLKRSG 560
            AE L + E   ++ ++ + ++   + E           GE+  + +E  G GTG+  +  
Sbjct: 1016 AEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVL 1075

Query: 561  SFSKLRASIRRSSEKLVR 578
               KL  ++ R   ++ R
Sbjct: 1076 EIEKLNETMERQRTEIAR 1093



 Score = 36.2 bits (82), Expect = 0.092
 Identities = 35/135 (25%), Positives = 63/135 (46%), Gaps = 4/135 (2%)

Query: 11   IKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSN 70
            +K D+  +  Q +     +  I+  E LK E N I+ +     +CL K  E   + E+  
Sbjct: 1492 VKADQQLRSLQADAKDLEQHKIKQEEILK-EINKIVAAKDSDFQCLSKKKEK--LTEELQ 1548

Query: 71   MIRKSLEMLELGLSE-AQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQ 129
             ++K +EM E       QV+      L A  +E +KL++QV    QE   L  +L + ++
Sbjct: 1549 KLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKE 1608

Query: 130  KLQKSEQSVAQLEEE 144
            +L   + S+ Q + +
Sbjct: 1609 ELHLLQGSMVQAKAD 1623



 Score = 33.1 bits (74), Expect = 0.78
 Identities = 38/164 (23%), Positives = 68/164 (41%), Gaps = 24/164 (14%)

Query: 12   KEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNM 71
            KE   +K   D+++SK     + +  L+ E     +SL +TL   K+     L E +  +
Sbjct: 1980 KELTDQKSKLDQVLSKVLAAEERVRTLQEEERWC-ESLEKTLSQTKRQ----LSEREQQL 2034

Query: 72   IRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLC----------------- 114
            + KS E+L L      +    S   N   +E++K   QV  L                  
Sbjct: 2035 VEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQ 2094

Query: 115  -QENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEF-MNQLKK 156
             QEN  ++ E+A  +   Q + +   +L +E   +++   +LKK
Sbjct: 2095 KQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKK 2138



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 43/179 (24%), Positives = 79/179 (44%), Gaps = 34/179 (18%)

Query: 8    MVYIKEDKLEKLT------QDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDE 61
            ++  K  +LEKL       Q E+    +Q+    E L     S++Q+  +  + L+  + 
Sbjct: 1574 LLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGET 1633

Query: 62   SNLVEEKSNMIRKSLEMLE----------LGLSEAQVMMALSNHLNAVESEKQKLRAQVR 111
               V EK N IR+   +LE          + +SE +  + L      +E E++ L+  +R
Sbjct: 1634 E--VTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQ--EIEKEEENLQVVLR 1689

Query: 112  RLCQENQWLR---DELANTQQKLQ----KSEQSVAQLE-------EEKKHLEFMNQLKK 156
            ++ +    L+   D L     +LQ    + +Q V++LE       EEK  LE + Q+ +
Sbjct: 1690 QMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQ 1748



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 15/58 (25%), Positives = 33/58 (56%), Gaps = 4/58 (6%)

Query: 92   LSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLE 149
            L N ++ +E   Q L+++ R    E +W+R     +++++++   ++  L +EKK LE
Sbjct: 1321 LENEVSRLEDIMQHLKSKKR----EERWMRASKRQSEKEMEELHHNIDDLLQEKKSLE 1374


>gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]
          Length = 1317

 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 51/232 (21%), Positives = 100/232 (43%), Gaps = 18/232 (7%)

Query: 23   EIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLE-- 80
            ++++  K ++Q  + LK E     Q +LE LKC + D ES L+E+    +    E+ +  
Sbjct: 835  KLVNLEKDLVQQKDILKKEVQEE-QEILECLKC-EHDKESRLLEKHDESVTDVTEVPQDF 892

Query: 81   ---------LGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKL 131
                     L   E Q+   L NHL  +  EKQ+       L +    L + L   ++++
Sbjct: 893  EKIKPVEYRLQYKERQLQYLLQNHLPTLLEEKQR---AFEILDRGPLSLDNTLYQVEKEM 949

Query: 132  QKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDEDDPGQGI 191
            ++ E+ +AQ +     L+ +    ++  +I+  E+K     KE L+       +   + +
Sbjct: 950  EEKEEQLAQYQANANQLQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERAL 1009

Query: 192  Q--QQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALE 241
               ++  SA       G EI  + + L +L      Q   + ++   ++ALE
Sbjct: 1010 ARLERRHSALQRHSTLGMEIEEQRQKLASLNSGSREQSGLQASLEAEQEALE 1061



 Score = 33.1 bits (74), Expect = 0.78
 Identities = 29/135 (21%), Positives = 70/135 (51%), Gaps = 21/135 (15%)

Query: 29  KQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNL--VEEKSNMIRKSLEMLELGLSEA 86
           +Q  + LE L+++     + L+E ++  +K D++ L  ++++    RK  E+++L + + 
Sbjct: 600 RQQREELEKLESK-----RKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQ 654

Query: 87  QVMMA-----LSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQL 141
           +  +      + N L  + +EK+K          E + LR++     QK ++ E++  ++
Sbjct: 655 EESLKRRSFHIENKLKDLLAEKEKF---------EEERLREQQEIELQKKRQEEETFLRV 705

Query: 142 EEEKKHLEFMNQLKK 156
           +EE + L+ +N  +K
Sbjct: 706 QEELQRLKELNNNEK 720


>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
          Length = 2481

 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 56/226 (24%), Positives = 93/226 (41%), Gaps = 26/226 (11%)

Query: 204 QGGYEIPARLRTLHNLVIQ----YASQGR--------------YEVAVPLCKQALEDLEK 245
           +G Y+   +L   H  + Q    YA+QGR              Y+ AV   +Q L+   +
Sbjct: 487 KGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISME 546

Query: 246 TSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAV 305
            +  D    A+    LA+ Y+    +  A     + L I  +   +D  + A  L+NL  
Sbjct: 547 VN--DRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIAREL--RDIQSEARALSNLGN 602

Query: 306 LYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRA 365
            +  RG+Y +A P  ++ L +   +  +D     K  +NL       G Y+E   YY++ 
Sbjct: 603 FHCSRGEYVQAAPYYEQYLRLAPDL--QDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQD 660

Query: 366 LEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRA 411
           L +   K   D  + AK   NL   +     F +AE   K +L+ A
Sbjct: 661 LAL--AKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLA 704



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 47/187 (25%), Positives = 77/187 (41%), Gaps = 7/187 (3%)

Query: 228 RYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREK 287
           +Y+ A+    Q LE  ++ S  D P        LA VY    KY  A     + L + +K
Sbjct: 769 KYDKALGYHTQELEVYQELS--DLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQK 826

Query: 288 TLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHP-DVAKQLNNLA 346
              KD    A    N+ +        +EA    ++ L + +++ G +   D  +   NL 
Sbjct: 827 L--KDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLG 884

Query: 347 LLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKE 406
              +  G YEE   YY++ L + Q+     D   AK    L + +   G  +QA   +++
Sbjct: 885 DCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQ--AKAYRGLGNGHRAMGSLQQALVCFEK 942

Query: 407 ILTRAHE 413
            L  AHE
Sbjct: 943 RLVVAHE 949



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 58/256 (22%), Positives = 97/256 (37%), Gaps = 43/256 (16%)

Query: 195 HSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDV 254
           H      A+Q   E+ +  R L N+   Y + G +E AV   +Q L+ + K  G+   + 
Sbjct: 337 HKQCVLLAKQSKDEL-SEARELGNMGAVYIAMGDFENAVQCHEQHLK-IAKDLGNKREEA 394

Query: 255 ATMLNILALVYRDQNKYKD----------AANLLNDALAIR------------------- 285
               N+ +  +  +N  K           A  L+  A+ +R                   
Sbjct: 395 RAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAK 454

Query: 286 ---EKTLG-----KDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPD 337
              E+ LG     KD  A     +NL +++  +G Y  A  L K  L I +++   D+  
Sbjct: 455 QYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQEL--SDYAA 512

Query: 338 VAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKF 397
             +   N+       G Y++   Y+++ L+I       D  + A T  NLA  Y   G  
Sbjct: 513 QGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEV--NDRASQASTHGNLAVAYQALGAH 570

Query: 398 KQAETLYKEILTRAHE 413
            +A   Y+  L  A E
Sbjct: 571 DRALQHYQNHLNIARE 586



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 55/236 (23%), Positives = 93/236 (39%), Gaps = 38/236 (16%)

Query: 208 EIPARLRTLHNLVIQYASQGRYEVAVPLCKQAL------EDLEKTS------GHDHPDVA 255
           +I +  R L NL   + S+G Y  A P  +Q L      +D+E         G+ H  + 
Sbjct: 589 DIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLG 648

Query: 256 TMLNILALVYRDQNKYKDAANLLNDALAI--------------REKTLGKDHPAVAATLN 301
                +    +D    KD  + L+ A A               + +   K   ++A +LN
Sbjct: 649 NYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLN 708

Query: 302 NLAVLYGKRGKYKEAEPLCKR----ALEIREKVLGKDHPDVAKQLNNLALLCQNQG---- 353
           N    +   G   +   +CK+    A++  E+ LG  H    ++L   A           
Sbjct: 709 NSQAKFRALGNLGDIF-ICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMI 767

Query: 354 -KYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEIL 408
            KY++   Y+ + LE+YQ     D P   +   +LA+ Y+  GK+  A   Y+E L
Sbjct: 768 QKYDKALGYHTQELEVYQEL--SDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQL 821



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 37/156 (23%), Positives = 61/156 (39%), Gaps = 31/156 (19%)

Query: 353 GKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAH 412
           G  E+   Y Q+ L++ +T LG D     +   NL S +  +G +++A T ++  L  A 
Sbjct: 248 GNTEKSTGYMQQDLDVAKT-LG-DQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLA- 304

Query: 413 EREFGSVDDENKPIWMHAEEREECKGKQKD----GTSFGEYGGW---YKACKV------D 459
                          M  ++RE             T+ G+Y      +K C +      D
Sbjct: 305 ---------------MKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKD 349

Query: 460 SPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRK 495
             +    L N+GA+Y   G FE A    E  ++  K
Sbjct: 350 ELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAK 385


>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
          Length = 872

 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 36/164 (21%), Positives = 82/164 (50%), Gaps = 15/164 (9%)

Query: 5   MSTMVYIKEDKLEKLT---QDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDE 61
           M    Y KE K ++     ++EI++ TK V QG     ++H++I   L    +  K+ D+
Sbjct: 105 MVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQ 164

Query: 62  --SNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVES----------EKQKLRAQ 109
             S +V+ + ++ + + +  E   S+ +   A+S     ++           +K+KL  +
Sbjct: 165 LLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKE 224

Query: 110 VRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQ 153
           ++++  +    + E+   QQ +QKS++ + +LE++ K  + +N+
Sbjct: 225 LKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNE 268


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.128    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,608,424
Number of Sequences: 37866
Number of extensions: 1025097
Number of successful extensions: 6781
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 186
Number of HSP's successfully gapped in prelim test: 582
Number of HSP's that attempted gapping in prelim test: 4686
Number of HSP's gapped (non-prelim): 2120
length of query: 618
length of database: 18,247,518
effective HSP length: 108
effective length of query: 510
effective length of database: 14,157,990
effective search space: 7220574900
effective search space used: 7220574900
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press