Guide to the Human Genome
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Search of human proteins with 113416187

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|113416187 PREDICTED: hypothetical protein [Homo sapiens]
         (262 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|169167066 PREDICTED: hypothetical protein [Homo sapiens]           559   e-159
gi|113416187 PREDICTED: hypothetical protein [Homo sapiens]           559   e-159
gi|113415691 PREDICTED: hypothetical protein [Homo sapiens]           559   e-159
gi|153792074 proline rich 12 [Homo sapiens]                            74   2e-13
gi|7706501 WW domain binding protein 11 [Homo sapiens]                 69   5e-12
gi|52485606 formin-like 2 [Homo sapiens]                               66   4e-11
gi|47132519 Ras association and pleckstrin homology domains 1 is...    64   1e-10
gi|150170670 piccolo isoform 2 [Homo sapiens]                          63   2e-10
gi|150378539 piccolo isoform 1 [Homo sapiens]                          63   2e-10
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...    63   3e-10
gi|40807465 zinc finger protein 341 [Homo sapiens]                     62   4e-10
gi|4557329 fas ligand [Homo sapiens]                                   62   7e-10
gi|160707881 formin 2 [Homo sapiens]                                   61   9e-10
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]                61   9e-10
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]                61   9e-10
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...    60   1e-09
gi|60460889 Myb protein P42POP [Homo sapiens]                          60   3e-09
gi|126090663 zinc finger homeodomain 4 [Homo sapiens]                  59   3e-09
gi|62000702 diacylglycerol kinase kappa [Homo sapiens]                 59   3e-09
gi|33356148 formin-like 1 [Homo sapiens]                               59   4e-09
gi|11386183 WAS protein family, member 2 [Homo sapiens]                58   7e-09
gi|156523244 membrane-associated ring finger (C3HC4) 11 [Homo sa...    58   1e-08
gi|169163027 PREDICTED: similar to Putative acrosin-like proteas...    57   1e-08
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo...    57   1e-08
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ...    57   1e-08
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]     57   1e-08
gi|157168329 formin 1 [Homo sapiens]                                   57   2e-08
gi|146134388 YLP motif containing 1 [Homo sapiens]                     57   2e-08
gi|56549694 enabled homolog isoform a [Homo sapiens]                   57   2e-08
gi|39930375 enabled homolog isoform b [Homo sapiens]                   57   2e-08

>gi|169167066 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 262

 Score =  559 bits (1440), Expect = e-159
 Identities = 262/262 (100%), Positives = 262/262 (100%)

Query: 1   MGKAGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRA 60
           MGKAGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRA
Sbjct: 1   MGKAGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRA 60

Query: 61  CSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAG 120
           CSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAG
Sbjct: 61  CSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAG 120

Query: 121 PAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAPLW 180
           PAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAPLW
Sbjct: 121 PAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAPLW 180

Query: 181 QACLVGWVKPQCVHTERRGAVERGSGLAEEDADQAPATQGNSELPRAALRVSEENRGDGR 240
           QACLVGWVKPQCVHTERRGAVERGSGLAEEDADQAPATQGNSELPRAALRVSEENRGDGR
Sbjct: 181 QACLVGWVKPQCVHTERRGAVERGSGLAEEDADQAPATQGNSELPRAALRVSEENRGDGR 240

Query: 241 NMGEGGLFPVHTHMHAATGRDS 262
           NMGEGGLFPVHTHMHAATGRDS
Sbjct: 241 NMGEGGLFPVHTHMHAATGRDS 262


>gi|113416187 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 262

 Score =  559 bits (1440), Expect = e-159
 Identities = 262/262 (100%), Positives = 262/262 (100%)

Query: 1   MGKAGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRA 60
           MGKAGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRA
Sbjct: 1   MGKAGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRA 60

Query: 61  CSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAG 120
           CSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAG
Sbjct: 61  CSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAG 120

Query: 121 PAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAPLW 180
           PAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAPLW
Sbjct: 121 PAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAPLW 180

Query: 181 QACLVGWVKPQCVHTERRGAVERGSGLAEEDADQAPATQGNSELPRAALRVSEENRGDGR 240
           QACLVGWVKPQCVHTERRGAVERGSGLAEEDADQAPATQGNSELPRAALRVSEENRGDGR
Sbjct: 181 QACLVGWVKPQCVHTERRGAVERGSGLAEEDADQAPATQGNSELPRAALRVSEENRGDGR 240

Query: 241 NMGEGGLFPVHTHMHAATGRDS 262
           NMGEGGLFPVHTHMHAATGRDS
Sbjct: 241 NMGEGGLFPVHTHMHAATGRDS 262


>gi|113415691 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 262

 Score =  559 bits (1440), Expect = e-159
 Identities = 262/262 (100%), Positives = 262/262 (100%)

Query: 1   MGKAGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRA 60
           MGKAGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRA
Sbjct: 1   MGKAGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRA 60

Query: 61  CSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAG 120
           CSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAG
Sbjct: 61  CSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAG 120

Query: 121 PAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAPLW 180
           PAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAPLW
Sbjct: 121 PAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAPLW 180

Query: 181 QACLVGWVKPQCVHTERRGAVERGSGLAEEDADQAPATQGNSELPRAALRVSEENRGDGR 240
           QACLVGWVKPQCVHTERRGAVERGSGLAEEDADQAPATQGNSELPRAALRVSEENRGDGR
Sbjct: 181 QACLVGWVKPQCVHTERRGAVERGSGLAEEDADQAPATQGNSELPRAALRVSEENRGDGR 240

Query: 241 NMGEGGLFPVHTHMHAATGRDS 262
           NMGEGGLFPVHTHMHAATGRDS
Sbjct: 241 NMGEGGLFPVHTHMHAATGRDS 262


>gi|153792074 proline rich 12 [Homo sapiens]
          Length = 2036

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 42/118 (35%), Positives = 51/118 (43%), Gaps = 28/118 (23%)

Query: 13   PPMSAQPPSSADTVPGTTY----PPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTE 68
            PP+   P ++++  P        PPP PPP PTP+P PPPP PPP P L     L+ PT 
Sbjct: 1434 PPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALPSPPPLVAPTP 1493

Query: 69   PAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPP 126
             +P  PP                        +PPP PP  P P     PAA P   PP
Sbjct: 1494 SSPPPPP------------------------LPPPPPPAMPSPPPPPPPAAAPLAAPP 1527



 Score = 68.6 bits (166), Expect = 5e-12
 Identities = 54/193 (27%), Positives = 69/193 (35%), Gaps = 44/193 (22%)

Query: 4    AGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPP-------------PTPRPPPPPPL 50
            A   G    P +  +PP +    P     PPPPPPP             PTP  PPPPPL
Sbjct: 1442 ANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPL 1501

Query: 51   PPPGPRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPR 110
            PPP P          P  P+P  PP                   AA+PL  PP  P  P 
Sbjct: 1502 PPPPP----------PAMPSPPPPP-----------------PPAAAPLAAPPEEPAAPS 1534

Query: 111  PLLCFLPAAGPAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASER- 169
            P    LP   P  L   +    + V        G+  G+G+   R   + R   + S + 
Sbjct: 1535 PEDPELPDTRPLHL--AKKQETAAVCGETDEEAGESGGEGIFRERDEFVIRAEDIPSLKL 1592

Query: 170  -GPRTHTPAPLWQ 181
                   P P+W+
Sbjct: 1593 ALQTGREPPPIWR 1605



 Score = 41.6 bits (96), Expect = 7e-04
 Identities = 36/113 (31%), Positives = 45/113 (39%), Gaps = 23/113 (20%)

Query: 32  PPPPPPPPPTPRPPP------------PPPLPPPGPRLLRACSLLLPTEPAPDLPPRRRS 79
           PPPPPP   + +P P            P  LPPP P+LL +   +L   P+P       S
Sbjct: 764 PPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPS---VLSHAPSP-------S 813

Query: 80  SSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPA-AGPAGLPPLRTSP 131
            S S     + +         PPP PP  P P+   L A     GL P   SP
Sbjct: 814 PSASKVGVHLLEPATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHGLEPAAPSP 866



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 54/194 (27%), Positives = 64/194 (32%), Gaps = 37/194 (19%)

Query: 13   PPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPL------------------PPPG 54
            PP+S  P S   +VP     P PP  P  P PPP                      P P 
Sbjct: 1305 PPLSP-PKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGGALEAAESEGLGLGCPSPC 1363

Query: 55   PRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQV--AASPLVPPP-------AP 105
             RL       L T     LP        S+A+ R  Q  +  A S L  PP       + 
Sbjct: 1364 KRLDEELKRNLET-----LPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTST 1418

Query: 106  PHCPRPLLCFLPAAGPAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPL 165
            P  P PL    PAA   G PPL   P +       P L +E             P+ PP 
Sbjct: 1419 PDGP-PL---APAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPP 1474

Query: 166  ASERGPRTHTPAPL 179
                 P   +P PL
Sbjct: 1475 PPPPQPALPSPPPL 1488



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 45/160 (28%), Positives = 53/160 (33%), Gaps = 17/160 (10%)

Query: 8    GGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPT 67
            G  A PP +  PP   +T   TT   PP   P T  P PP P  P         SLL P 
Sbjct: 1688 GSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEKP---------SLLRPV 1738

Query: 68   EPAPDLPPRRRSSSRSLARGRIT---QCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGL 124
            E   +     R   R L   R T   Q +   S     PA    P+     + A  P   
Sbjct: 1739 EKEKEKEKVTR-GERPLRGERATSGRQTRPERSLATGQPATSRLPKARPTKVKAEPPPKK 1797

Query: 125  PPLRTSPCSGVTFAGRPRLG----QESGQGVAARRRRALP 160
                     G   AG    G     ES  G  +   RA+P
Sbjct: 1798 RKKWLKEAGGNATAGGGPPGSSSDSESSPGAPSEDERAVP 1837



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 33/87 (37%), Positives = 35/87 (40%), Gaps = 4/87 (4%)

Query: 19  PPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDLPPRRR 78
           P  SA  V      P      P P PPPPPP PPP P  L A       EPA    PR R
Sbjct: 812 PSPSASKVGVHLLEPATRDGAPQP-PPPPPPPPPPMPLQLEAHLRSHGLEPAAP-SPRLR 869

Query: 79  SSSRSLARGRITQCQVAASPLVPPPAP 105
                   G + +   A  PL  PPAP
Sbjct: 870 PEESLDPPGAMQELLGALEPL--PPAP 894



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 31/94 (32%), Positives = 40/94 (42%), Gaps = 12/94 (12%)

Query: 2    GKAGGEGGEAGPPMSAQP------PSSADTVP-GTTYPPPPPPPPPTPRPPPPPPLPPPG 54
            G+A G G E  P +   P      PS+ +  P G     P    PP P PPPPPP P   
Sbjct: 996  GRASGAGPET-PGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAPPPPPPPPPPPAPASE 1054

Query: 55   PRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGR 88
            P+      +   T+P   L    ++SS  L R R
Sbjct: 1055 PKGGLTSPIFCSTKPKKLL----KTSSFHLLRRR 1084



 Score = 37.0 bits (84), Expect = 0.017
 Identities = 36/126 (28%), Positives = 43/126 (34%), Gaps = 28/126 (22%)

Query: 2    GKAGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRAC 61
            G A  + G+AGPP     P +                     PP PP   P GP      
Sbjct: 956  GGAADDYGKAGPPEDEGDPKAG-----------------AGPPPGPPAYDPYGPYCPGRA 998

Query: 62   SLLLPTEPA----PDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLP 117
            S   P  P     P+ PP   S+  +   G I   Q       PPP PP  P P     P
Sbjct: 999  SGAGPETPGLGLDPNKPPELPSTVNAEPLGLI---QSGPHQAAPPPPPPPPPPP----AP 1051

Query: 118  AAGPAG 123
            A+ P G
Sbjct: 1052 ASEPKG 1057



 Score = 33.5 bits (75), Expect = 0.19
 Identities = 30/93 (32%), Positives = 34/93 (36%), Gaps = 15/93 (16%)

Query: 27  PGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACS-------------LLLPTEPAPDL 73
           P    P   PP  P P  PPPPP   P    L A S             L   +  AP  
Sbjct: 216 PAGLGPAQTPPYRPGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGAAPGP 275

Query: 74  PPRRRSSSRSLARGRITQCQVAASPLVPPPAPP 106
           PP  R+  R     +  Q   +A P  PPP PP
Sbjct: 276 PPPERALPRQDTVIKHYQRPASAQP--PPPPPP 306



 Score = 33.1 bits (74), Expect = 0.25
 Identities = 22/83 (26%), Positives = 34/83 (40%), Gaps = 11/83 (13%)

Query: 9    GEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTE 68
            G+A  P+SA          G +  PPP  P P P+P  P       P   +     +P  
Sbjct: 1678 GQAKNPVSA----------GGSSAPPPKAPAPPPKPETPEKTTSEKPP-EQTPETAMPEP 1726

Query: 69   PAPDLPPRRRSSSRSLARGRITQ 91
            PAP+ P   R   +   + ++T+
Sbjct: 1727 PAPEKPSLLRPVEKEKEKEKVTR 1749



 Score = 29.3 bits (64), Expect = 3.6
 Identities = 15/55 (27%), Positives = 24/55 (43%)

Query: 68  EPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPA 122
           + +P  PP    S++    G + +      PLV PP PP     +L   P+  P+
Sbjct: 761 QKSPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPS 815



 Score = 28.1 bits (61), Expect = 8.1
 Identities = 18/60 (30%), Positives = 20/60 (33%), Gaps = 16/60 (26%)

Query: 2   GKAGGEGGEAGPPMSAQPPS----------------SADTVPGTTYPPPPPPPPPTPRPP 45
           GKA G GG  G   S   P                 + D     +Y   PP PP  P PP
Sbjct: 430 GKASGAGGAGGQAYSPGQPQGLLGPQAYGQGFGGGQAQDLSKAPSYSGGPPQPPSGPPPP 489


>gi|7706501 WW domain binding protein 11 [Homo sapiens]
          Length = 641

 Score = 68.6 bits (166), Expect = 5e-12
 Identities = 70/233 (30%), Positives = 90/233 (38%), Gaps = 39/233 (16%)

Query: 16  SAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDLPP 75
           S+Q  +   +VP +    PP P PP   PPP PPL PPGP         LP  P P  PP
Sbjct: 387 SSQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAPPLRPPGP------PTGLPPGPPPGAPP 440

Query: 76  RRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSPCSGV 135
             R       RG + +      P   PP PP  P P L       P G PP R  P    
Sbjct: 441 FLRPPGMPGLRGPLPRLLPPGPPPGRPPGPPPGPPPGL-------PPG-PPPRGPP---- 488

Query: 136 TFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPR---THTPAPLWQACLVGWVKPQC 192
                PRL   +  G+   R   +   PPL    GP       PAPL    ++    P  
Sbjct: 489 -----PRLPPPAPPGIPPPRPGMM--RPPLVPPLGPAPPGLFPPAPLPNPGVLS-APPNL 540

Query: 193 VHTERRGAVERGSGLAEEDADQAPATQGNSELPRA--------ALRVSEENRG 237
           +  +R  A +  +   E+ A    + +     P+A        ALRV  EN+G
Sbjct: 541 I--QRPKADDTSAATIEKKATATISAKPQITNPKAEITRFVPTALRVRRENKG 591



 Score = 51.6 bits (122), Expect = 7e-07
 Identities = 26/60 (43%), Positives = 30/60 (50%), Gaps = 1/60 (1%)

Query: 12  GPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAP 71
           GPP    P       PG    PPP  PPP   PP PP +PPP P ++R   L+ P  PAP
Sbjct: 461 GPPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMMRP-PLVPPLGPAP 519



 Score = 37.7 bits (86), Expect = 0.010
 Identities = 29/79 (36%), Positives = 36/79 (45%), Gaps = 18/79 (22%)

Query: 13  PPMSAQPPSSADTVPGTTYPPPP-------------PPPPPTPRPPPPPPLPPPGPRLLR 59
           P   AQPPS       + Y PP              P  PP  +PP PPP PPP P++++
Sbjct: 157 PLPGAQPPSILKKT--SAYGPPTRAVSILPLLGHGVPRLPPGRKPPGPPPGPPP-PQVVQ 213

Query: 60  ACSLLLPTEPAPDLPPRRR 78
                +    A DLPPRRR
Sbjct: 214 MYGRKVGF--ALDLPPRRR 230


>gi|52485606 formin-like 2 [Homo sapiens]
          Length = 1092

 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 38/83 (45%), Positives = 39/83 (46%), Gaps = 11/83 (13%)

Query: 1   MGKAGGEGGEAGPPMSAQPPSSAD---------TVPGTTYPPPPPPPPPTPRPPPPPPLP 51
           MG A    G   PP    PPSS           T P    PPPPPPPPP P PPPPPPLP
Sbjct: 518 MGAASS--GPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLP 575

Query: 52  PPGPRLLRACSLLLPTEPAPDLP 74
            P    + A  L  P   AP LP
Sbjct: 576 GPAAETVPAPPLAPPLPSAPPLP 598



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 40/130 (30%), Positives = 51/130 (39%), Gaps = 25/130 (19%)

Query: 6   GEGGEAGPPMSAQPPSS--ADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPG--PRLLRAC 61
           G+G  A  P+ A    S  ++ V G +  P        P PPPPPPLPP    P  ++  
Sbjct: 487 GDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNG 546

Query: 62  SLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGP 121
            +  P  P P  PP                      P  PPP PP  P P    +PA  P
Sbjct: 547 PVTPPMPPPPPPPP-------------------PPPPPPPPPPPPPLPGPAAETVPA--P 585

Query: 122 AGLPPLRTSP 131
              PPL ++P
Sbjct: 586 PLAPPLPSAP 595



 Score = 35.8 bits (81), Expect = 0.039
 Identities = 20/60 (33%), Positives = 21/60 (35%), Gaps = 13/60 (21%)

Query: 7   EGGEAGPPMSAQPPSSADTVPGTTYPPPPPPP-------------PPTPRPPPPPPLPPP 53
           + G   PPM   PP      P    PPPPP P             PP P  PP P    P
Sbjct: 544 QNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSP 603


>gi|47132519 Ras association and pleckstrin homology domains 1
           isoform 1 [Homo sapiens]
          Length = 1250

 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 54/188 (28%), Positives = 69/188 (36%), Gaps = 33/188 (17%)

Query: 13  PPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPP-------------GPRLLR 59
           PP+S QP            PP PPPPPP P PPPPPP PPP              P  ++
Sbjct: 607 PPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVK 666

Query: 60  ACSLLLPTEPA--------PDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRP 111
             ++      +        P  PP  +S S         Q  V  + +VPPP PP  P  
Sbjct: 667 YSTITRLQNASQHSGALFKPPTPPVMQSQSVK------PQILVPPNGVVPPPPPPPPPP- 719

Query: 112 LLCFLPAAGPAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGP 171
                P +  A L P   +P      A  P L     Q +        P  PP+ +   P
Sbjct: 720 ----TPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPP 775

Query: 172 RTHTPAPL 179
           +   P PL
Sbjct: 776 QA-PPKPL 782



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 43/122 (35%), Positives = 54/122 (44%), Gaps = 25/122 (20%)

Query: 13  PPMSAQPPS-SADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAP 71
           P  SA PP      V   T   PP PPPP P P P PP  PP P         L T PAP
Sbjct: 738 PQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKP---------LVTIPAP 788

Query: 72  DLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLL--CFLPAAGPAGLPPLRT 129
                  +S++++A   +TQ   AA P   PP PP   +P     ++P + P   PP+  
Sbjct: 789 -------TSTKTVA-PVVTQ---AAPPTPTPPVPPAKKQPAFPASYIPPSPPT--PPVPV 835

Query: 130 SP 131
            P
Sbjct: 836 PP 837



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 42/151 (27%), Positives = 56/151 (37%), Gaps = 25/151 (16%)

Query: 10  EAGPPMSAQPPSSADTVPG--TTYPPPPPPPPPTPRPPP-----------PPPLP-PPGP 55
           +A PP    P   A   P    +Y PP PP PP P PPP           PPP P  P P
Sbjct: 800 QAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVP 859

Query: 56  RLLRACSLLLPTEPAP---------DLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPP 106
            +++  +   P  P P          +P      S    + +  + Q ++ P+  P  PP
Sbjct: 860 SVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAK-PKWQPSSIPVPSPDFPP 918

Query: 107 HCPRPLLCF-LPAAGPAGLPPLRTSPCSGVT 136
             P   L F  P   P   PP    P +  T
Sbjct: 919 PPPESSLVFPPPPPSPVPAPPPPPPPTASPT 949



 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 43/131 (32%), Positives = 50/131 (38%), Gaps = 24/131 (18%)

Query: 28  GTTYPPPPPP-------------PPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDLP 74
           G  + PP PP             PP    PPPPPP PPP P    A + L P   AP L 
Sbjct: 681 GALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPG--SAMAQLKPAPCAPSL- 737

Query: 75  PRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSPCSG 134
           P+  +    L   ++      A P  PPP P   P P     P A P    PL T P   
Sbjct: 738 PQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLP-----PQAPP---KPLVTIPAPT 789

Query: 135 VTFAGRPRLGQ 145
            T    P + Q
Sbjct: 790 STKTVAPVVTQ 800



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 38/124 (30%), Positives = 49/124 (39%), Gaps = 35/124 (28%)

Query: 13   PPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPP-------PGPRLLRACSLLL 65
            P     PP S+       +PPPPP P P P PPPPP   P       PG +  +  S   
Sbjct: 914  PDFPPPPPESS-----LVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSS--- 965

Query: 66   PTEPAPDLPPRRRSSSRSLAR---------------GRITQCQVAASP---LVPPPAPPH 107
            P    P   P+R SS +S +                 + T    + SP    +PPPA P 
Sbjct: 966  PGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAP- 1024

Query: 108  CPRP 111
             P+P
Sbjct: 1025 -PKP 1027



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 36/126 (28%), Positives = 47/126 (37%), Gaps = 17/126 (13%)

Query: 13  PPMSAQPPSSADTVPGTTYPPPPPPPPPTPRP--PPPPPLPPPGPRLLRACSLLLPTE-- 68
           PP    P  S      + +PPPP PP    +P  P P  + P  P  ++A     P+   
Sbjct: 851 PPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIP 910

Query: 69  -PAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPL 127
            P+PD PP    SS            +   P  P P P   P P     P    +G P  
Sbjct: 911 VPSPDFPPPPPESS------------LVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGK 958

Query: 128 RTSPCS 133
           +TS  S
Sbjct: 959 KTSKTS 964



 Score = 45.1 bits (105), Expect = 6e-05
 Identities = 27/96 (28%), Positives = 40/96 (41%), Gaps = 13/96 (13%)

Query: 10  EAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEP 69
           ++ P + A+P     ++P  +   PPPPP  +   PPPPP P P P             P
Sbjct: 893 QSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAP-------------P 939

Query: 70  APDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAP 105
            P  P    +  +S + G+ T    +     PPP P
Sbjct: 940 PPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTP 975



 Score = 35.8 bits (81), Expect = 0.039
 Identities = 41/161 (25%), Positives = 57/161 (35%), Gaps = 35/161 (21%)

Query: 19   PPSSADTVPGTTYPPPPPPPPPTPRPPPP------------PPLPPPGPRLLRACSLLLP 66
            PPS +D          PPPPP T  P PP            P +    P+  +   + + 
Sbjct: 1067 PPSDSDF---------PPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVK 1117

Query: 67   TEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAP--PHCPRPLLCFLPAAGPAGL 124
              P P  P R  S+       R+TQ +++  P +    P  P  P+  L    +  P  L
Sbjct: 1118 KAPPPTRPKRNDST-------RLTQAEISEQPTMATVVPQVPTSPKSSL----SVQPGFL 1166

Query: 125  PPL-RTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPP 164
              L RT     +T  G         +  A     ALP  PP
Sbjct: 1167 ADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPP 1207



 Score = 33.1 bits (74), Expect = 0.25
 Identities = 36/132 (27%), Positives = 45/132 (34%), Gaps = 31/132 (23%)

Query: 3    KAGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPP---------PPTPRPPP-----PP 48
            K    GG+  PP + Q  SS  +  G  +P P  P          PP     P     PP
Sbjct: 962  KTSSPGGKKPPP-TPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPP 1020

Query: 49   PLPPPGPRLLRACSLLLP--------TEPAPDLPPRRRSSSRSLARGRITQCQVAASPLV 100
            P  PP P  L    + LP        +  AP L  R + S        + +     S   
Sbjct: 1021 PAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDS--------VVEFPSPPSDSD 1072

Query: 101  PPPAPPHCPRPL 112
             PP PP    PL
Sbjct: 1073 FPPPPPETELPL 1084


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 63.2 bits (152), Expect = 2e-10
 Identities = 40/134 (29%), Positives = 57/134 (42%), Gaps = 23/134 (17%)

Query: 14   PMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDL 73
            P   +P   + ++  +  PPPPPPPPP P PPPPPP PPP P          PT P P +
Sbjct: 2387 PAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPP---------PTSPKPTI 2437

Query: 74   PPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPL------LCFLPAAGPAGLPPL 127
             P+++ +        +      A+PL            L      +  +    P  +PP 
Sbjct: 2438 LPKKKLT--------VASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPK 2489

Query: 128  RTSPCSGVTFAGRP 141
             +S  SG+ F  RP
Sbjct: 2490 PSSIPSGLVFTHRP 2503



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 33/102 (32%), Positives = 42/102 (41%), Gaps = 20/102 (19%)

Query: 14  PMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPP----PPLPPPGPRLLRACSLLLPTEP 69
           P SA+PPS     PG+T PPP  P P  P P  P    PP   PG     A       +P
Sbjct: 494 PGSAKPPSQQ---PGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSA------QQP 544

Query: 70  APDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRP 111
           +P  P  ++S+      G       +  PL PP   P   +P
Sbjct: 545 SPAKPSAQQSTKPVSQTG-------SGKPLQPPTVSPSAKQP 579



 Score = 37.4 bits (85), Expect = 0.013
 Identities = 40/151 (26%), Positives = 50/151 (33%), Gaps = 41/151 (27%)

Query: 8   GGEAGPPMSAQPPSSADTV-------PGTTYPPPPPP----PPPTPRPPPPPPL------ 50
           G E   P  A+PP+    +       PGT  PP  PP    PP  P  P  PP       
Sbjct: 320 GHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSE 379

Query: 51  ----PPPGPRLLRACSLLLPT---EPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPP 103
                 PGP+ L     +  T   +P P  PP              TQ      PL   P
Sbjct: 380 KPSSEQPGPKALAQPPGVGKTPAQQPGPAKPP--------------TQQVGTPKPLAQQP 425

Query: 104 ---APPHCPRPLLCFLPAAGPAGLPPLRTSP 131
              +P   P P    +   GP  +P  +  P
Sbjct: 426 GLQSPAKAPGPTKTPVQQPGPGKIPAQQAGP 456



 Score = 37.4 bits (85), Expect = 0.013
 Identities = 44/171 (25%), Positives = 62/171 (36%), Gaps = 30/171 (17%)

Query: 10  EAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEP 69
           +  P    + P  A T      P P   P P   P PP P P  G            T P
Sbjct: 845 QVDPVQKKEEPKKAQTKMS---PKPDAKPMPKGSPTPPGPRPTAG-----------QTVP 890

Query: 70  APDLPPRRRSSSR--SLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPL 127
            P   P+ +  SR  SL  G IT      +P   P  P       L    A+       +
Sbjct: 891 TPQQSPKPQEQSRRFSLNLGSITD-----APKSQPTTPQETVTGKLFGFGAS-------I 938

Query: 128 RTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAP 178
            +   + ++ AG+P    +SG G A  ++   P  PP  S+  P++   AP
Sbjct: 939 FSQASNLISTAGQPGPHSQSGPG-APMKQAPAPSQPP-TSQGPPKSTGQAP 987



 Score = 37.0 bits (84), Expect = 0.017
 Identities = 30/119 (25%), Positives = 37/119 (31%), Gaps = 24/119 (20%)

Query: 13  PPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPD 72
           P   A P  ++    G T PP   P P  P P  P P  PP            P +P   
Sbjct: 450 PAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPP------------PQQPGSA 497

Query: 73  LPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSP 131
            PP ++  S                P  P PA P   +P     P+  P    P    P
Sbjct: 498 KPPSQQPGS------------TKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQP 544



 Score = 36.2 bits (82), Expect = 0.030
 Identities = 35/134 (26%), Positives = 52/134 (38%), Gaps = 10/134 (7%)

Query: 10  EAGP-PMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPG---PRLLRACSLLL 65
           +AGP   SAQ   +  T P +  P P  PPP  P P  PPP  P     P      +   
Sbjct: 453 QAGPGKTSAQ--QTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPP 510

Query: 66  PTEPAPDLP-PRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLL---CFLPAAGP 121
           P +P P  P P++  S++  ++   +    A  P    P+     +P+       P   P
Sbjct: 511 PQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPP 570

Query: 122 AGLPPLRTSPCSGV 135
              P  +  P  G+
Sbjct: 571 TVSPSAKQPPSQGL 584



 Score = 35.4 bits (80), Expect = 0.051
 Identities = 44/174 (25%), Positives = 61/174 (35%), Gaps = 21/174 (12%)

Query: 10  EAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPP---PGPRLLRACSLLLP 66
           +A  P + Q    AD V G +  P  P P   P   P P  PP   PG            
Sbjct: 277 DASRPQTKQ----ADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHE---------K 323

Query: 67  TEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPP 126
           ++P P  PP + S    L +    Q      P+ PP       +PL    P A   G   
Sbjct: 324 SQPGPAKPPAQPS---GLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEK 380

Query: 127 LRTSPCSGVTFAGRPRLGQESGQ--GVAARRRRALPRHPPLASERGPRTHTPAP 178
             +        A  P +G+   Q  G A    + +    PLA + G ++   AP
Sbjct: 381 PSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAP 434



 Score = 32.3 bits (72), Expect = 0.43
 Identities = 33/125 (26%), Positives = 44/125 (35%), Gaps = 25/125 (20%)

Query: 11   AGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPA 70
            A PP    PP      P    PPP PP    P  P P  LP    + L   S +    P 
Sbjct: 2403 AQPPPPPPPPPPPPPPPPPPPPPPLPP----PTSPKPTILP---KKKLTVASPVTTATPL 2455

Query: 71   PDLPPRRRSSSRSLARG-RITQCQVAASPLVP-----------------PPAPPHCPRPL 112
             D      +++   + G  +T+    A P VP                 P  PP  P+P+
Sbjct: 2456 FDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPV 2515

Query: 113  LCFLP 117
            +  LP
Sbjct: 2516 IPQLP 2520



 Score = 32.0 bits (71), Expect = 0.56
 Identities = 20/82 (24%), Positives = 29/82 (35%), Gaps = 3/82 (3%)

Query: 8   GGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLL--- 64
           G    PP    P   +   PG+T PP   P    P    P P  P   +  +  S     
Sbjct: 505 GSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSG 564

Query: 65  LPTEPAPDLPPRRRSSSRSLAR 86
            P +P    P  ++  S+ L +
Sbjct: 565 KPLQPPTVSPSAKQPPSQGLPK 586



 Score = 31.6 bits (70), Expect = 0.73
 Identities = 34/132 (25%), Positives = 42/132 (31%), Gaps = 34/132 (25%)

Query: 19   PPSSADTVP------------GTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLP 66
            PPSS   +P            G T+    P        P    LP       R+ SL + 
Sbjct: 2343 PPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDIS 2402

Query: 67   TEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPP 126
             +P P  PP                      P  PPP PP  P P L    +  P  LP 
Sbjct: 2403 AQPPPPPPP----------------------PPPPPPPPPPPPPPPLPPPTSPKPTILPK 2440

Query: 127  LRTSPCSGVTFA 138
             + +  S VT A
Sbjct: 2441 KKLTVASPVTTA 2452



 Score = 30.4 bits (67), Expect = 1.6
 Identities = 34/136 (25%), Positives = 47/136 (34%), Gaps = 22/136 (16%)

Query: 5   GGEGGEAGPPMSAQPPSSADTVP----GTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRA 60
           G     A  P  A+P +   T P    G+  P  PP   P+ + PP   LP         
Sbjct: 535 GSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPK------TI 588

Query: 61  CSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRP-----LLCF 115
           C L   TE    +P +   ++        T+CQ     L      PH         L C 
Sbjct: 589 CPLCNTTELLLHVPEKANFNT-------CTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQ 641

Query: 116 LPAAGPAGLPPLRTSP 131
           +  A    L P+ +SP
Sbjct: 642 MKRALGGDLAPVPSSP 657



 Score = 28.5 bits (62), Expect = 6.2
 Identities = 12/41 (29%), Positives = 17/41 (41%)

Query: 9   GEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPP 49
           G+ GP   + P +     P  + PP    PP +    PP P
Sbjct: 950 GQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAP 990


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 63.2 bits (152), Expect = 2e-10
 Identities = 40/134 (29%), Positives = 57/134 (42%), Gaps = 23/134 (17%)

Query: 14   PMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDL 73
            P   +P   + ++  +  PPPPPPPPP P PPPPPP PPP P          PT P P +
Sbjct: 2387 PAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPP---------PTSPKPTI 2437

Query: 74   PPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPL------LCFLPAAGPAGLPPL 127
             P+++ +        +      A+PL            L      +  +    P  +PP 
Sbjct: 2438 LPKKKLT--------VASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPK 2489

Query: 128  RTSPCSGVTFAGRP 141
             +S  SG+ F  RP
Sbjct: 2490 PSSIPSGLVFTHRP 2503



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 33/102 (32%), Positives = 42/102 (41%), Gaps = 20/102 (19%)

Query: 14  PMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPP----PPLPPPGPRLLRACSLLLPTEP 69
           P SA+PPS     PG+T PPP  P P  P P  P    PP   PG     A       +P
Sbjct: 494 PGSAKPPSQQ---PGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSA------QQP 544

Query: 70  APDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRP 111
           +P  P  ++S+      G       +  PL PP   P   +P
Sbjct: 545 SPAKPSAQQSTKPVSQTG-------SGKPLQPPTVSPSAKQP 579



 Score = 37.4 bits (85), Expect = 0.013
 Identities = 40/151 (26%), Positives = 50/151 (33%), Gaps = 41/151 (27%)

Query: 8   GGEAGPPMSAQPPSSADTV-------PGTTYPPPPPP----PPPTPRPPPPPPL------ 50
           G E   P  A+PP+    +       PGT  PP  PP    PP  P  P  PP       
Sbjct: 320 GHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSE 379

Query: 51  ----PPPGPRLLRACSLLLPT---EPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPP 103
                 PGP+ L     +  T   +P P  PP              TQ      PL   P
Sbjct: 380 KPSSEQPGPKALAQPPGVGKTPAQQPGPAKPP--------------TQQVGTPKPLAQQP 425

Query: 104 ---APPHCPRPLLCFLPAAGPAGLPPLRTSP 131
              +P   P P    +   GP  +P  +  P
Sbjct: 426 GLQSPAKAPGPTKTPVQQPGPGKIPAQQAGP 456



 Score = 37.4 bits (85), Expect = 0.013
 Identities = 44/171 (25%), Positives = 62/171 (36%), Gaps = 30/171 (17%)

Query: 10  EAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEP 69
           +  P    + P  A T      P P   P P   P PP P P  G            T P
Sbjct: 845 QVDPVQKKEEPKKAQTKMS---PKPDAKPMPKGSPTPPGPRPTAG-----------QTVP 890

Query: 70  APDLPPRRRSSSR--SLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPL 127
            P   P+ +  SR  SL  G IT      +P   P  P       L    A+       +
Sbjct: 891 TPQQSPKPQEQSRRFSLNLGSITD-----APKSQPTTPQETVTGKLFGFGAS-------I 938

Query: 128 RTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAP 178
            +   + ++ AG+P    +SG G A  ++   P  PP  S+  P++   AP
Sbjct: 939 FSQASNLISTAGQPGPHSQSGPG-APMKQAPAPSQPP-TSQGPPKSTGQAP 987



 Score = 37.0 bits (84), Expect = 0.017
 Identities = 30/119 (25%), Positives = 37/119 (31%), Gaps = 24/119 (20%)

Query: 13  PPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPD 72
           P   A P  ++    G T PP   P P  P P  P P  PP            P +P   
Sbjct: 450 PAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPP------------PQQPGSA 497

Query: 73  LPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSP 131
            PP ++  S                P  P PA P   +P     P+  P    P    P
Sbjct: 498 KPPSQQPGS------------TKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQP 544



 Score = 36.2 bits (82), Expect = 0.030
 Identities = 35/134 (26%), Positives = 52/134 (38%), Gaps = 10/134 (7%)

Query: 10  EAGP-PMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPG---PRLLRACSLLL 65
           +AGP   SAQ   +  T P +  P P  PPP  P P  PPP  P     P      +   
Sbjct: 453 QAGPGKTSAQ--QTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPP 510

Query: 66  PTEPAPDLP-PRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLL---CFLPAAGP 121
           P +P P  P P++  S++  ++   +    A  P    P+     +P+       P   P
Sbjct: 511 PQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPP 570

Query: 122 AGLPPLRTSPCSGV 135
              P  +  P  G+
Sbjct: 571 TVSPSAKQPPSQGL 584



 Score = 35.4 bits (80), Expect = 0.051
 Identities = 44/174 (25%), Positives = 61/174 (35%), Gaps = 21/174 (12%)

Query: 10  EAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPP---PGPRLLRACSLLLP 66
           +A  P + Q    AD V G +  P  P P   P   P P  PP   PG            
Sbjct: 277 DASRPQTKQ----ADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHE---------K 323

Query: 67  TEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPP 126
           ++P P  PP + S    L +    Q      P+ PP       +PL    P A   G   
Sbjct: 324 SQPGPAKPPAQPS---GLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEK 380

Query: 127 LRTSPCSGVTFAGRPRLGQESGQ--GVAARRRRALPRHPPLASERGPRTHTPAP 178
             +        A  P +G+   Q  G A    + +    PLA + G ++   AP
Sbjct: 381 PSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAP 434



 Score = 32.3 bits (72), Expect = 0.43
 Identities = 33/125 (26%), Positives = 44/125 (35%), Gaps = 25/125 (20%)

Query: 11   AGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPA 70
            A PP    PP      P    PPP PP    P  P P  LP    + L   S +    P 
Sbjct: 2403 AQPPPPPPPPPPPPPPPPPPPPPPLPP----PTSPKPTILP---KKKLTVASPVTTATPL 2455

Query: 71   PDLPPRRRSSSRSLARG-RITQCQVAASPLVP-----------------PPAPPHCPRPL 112
             D      +++   + G  +T+    A P VP                 P  PP  P+P+
Sbjct: 2456 FDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPV 2515

Query: 113  LCFLP 117
            +  LP
Sbjct: 2516 IPQLP 2520



 Score = 32.0 bits (71), Expect = 0.56
 Identities = 20/82 (24%), Positives = 29/82 (35%), Gaps = 3/82 (3%)

Query: 8   GGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLL--- 64
           G    PP    P   +   PG+T PP   P    P    P P  P   +  +  S     
Sbjct: 505 GSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSG 564

Query: 65  LPTEPAPDLPPRRRSSSRSLAR 86
            P +P    P  ++  S+ L +
Sbjct: 565 KPLQPPTVSPSAKQPPSQGLPK 586



 Score = 31.6 bits (70), Expect = 0.73
 Identities = 34/132 (25%), Positives = 42/132 (31%), Gaps = 34/132 (25%)

Query: 19   PPSSADTVP------------GTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLP 66
            PPSS   +P            G T+    P        P    LP       R+ SL + 
Sbjct: 2343 PPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDIS 2402

Query: 67   TEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPP 126
             +P P  PP                      P  PPP PP  P P L    +  P  LP 
Sbjct: 2403 AQPPPPPPP----------------------PPPPPPPPPPPPPPPLPPPTSPKPTILPK 2440

Query: 127  LRTSPCSGVTFA 138
             + +  S VT A
Sbjct: 2441 KKLTVASPVTTA 2452



 Score = 30.4 bits (67), Expect = 1.6
 Identities = 34/136 (25%), Positives = 47/136 (34%), Gaps = 22/136 (16%)

Query: 5   GGEGGEAGPPMSAQPPSSADTVP----GTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRA 60
           G     A  P  A+P +   T P    G+  P  PP   P+ + PP   LP         
Sbjct: 535 GSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPK------TI 588

Query: 61  CSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRP-----LLCF 115
           C L   TE    +P +   ++        T+CQ     L      PH         L C 
Sbjct: 589 CPLCNTTELLLHVPEKANFNT-------CTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQ 641

Query: 116 LPAAGPAGLPPLRTSP 131
           +  A    L P+ +SP
Sbjct: 642 MKRALGGDLAPVPSSP 657



 Score = 28.5 bits (62), Expect = 6.2
 Identities = 12/41 (29%), Positives = 17/41 (41%)

Query: 9   GEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPP 49
           G+ GP   + P +     P  + PP    PP +    PP P
Sbjct: 950 GQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAP 990


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 54/169 (31%), Positives = 62/169 (36%), Gaps = 25/169 (14%)

Query: 27  PGTTYPPPPPPPPPTPRPPPPPPLP-----------PPGPRLLRACSLLLPTEPA--PDL 73
           P    P PPPP PP P PP PPPLP           PPGP       ++ P  P   P  
Sbjct: 167 PRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPP 226

Query: 74  PPRRRSSSRSLARGRITQCQVAASPLVP---PPAPPHCPRPLLCFLPAAGPAGLPPLRTS 130
           PP    +   L    +   +     L P   PP PP  P PLL       P G P L+  
Sbjct: 227 PPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPP--PLPLL------PPCGYPGLKAE 278

Query: 131 PCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAPL 179
           P S    A  P          A+   RA    PPL       + TP PL
Sbjct: 279 PASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNS-SSETPPPL 326



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 58/205 (28%), Positives = 70/205 (34%), Gaps = 41/205 (20%)

Query: 4   AGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPP----------------PPPPTPRPPPP 47
           AGG+ G+     +  P     T+ G   PP  P                P P  P PPPP
Sbjct: 118 AGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPP 177

Query: 48  PPLPPPGPRLLRACSLLLPTEPAPDLPPRRR---SSSRSLARGR--ITQCQVAASPLVPP 102
            P PPP P         LP  P P   P +    S    L +G   +    V  +P  PP
Sbjct: 178 TPPPPPPP---------LP-PPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPP 227

Query: 103 PAPPHCPRPL--------LCFLPAAGPAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAAR 154
           P PP  P PL            P   P  LPP+   P   +   G P L  E        
Sbjct: 228 PPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPI-PPPLPLLPPCGYPGLKAEPASPAQDA 286

Query: 155 RRRALPRHP-PLASERGPRTHTPAP 178
           +    P  P P  +   PR   PAP
Sbjct: 287 QEPPAPPPPLPPYASCSPRASLPAP 311



 Score = 54.7 bits (130), Expect = 8e-08
 Identities = 63/213 (29%), Positives = 70/213 (32%), Gaps = 48/213 (22%)

Query: 12  GPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPP------------------PPLPPP 53
           GP      P  A  VP    PPPPPP PPTP P PP                  PP+PPP
Sbjct: 205 GPLTKGNLPVVAPPVPCAPPPPPPPP-PPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPP 263

Query: 54  GPRLLRAC--------------SLLLPTEPAPDLPPRRRSSSR-SLARGRITQCQVAASP 98
            P LL  C                  P  P P LPP    S R SL    +    V +S 
Sbjct: 264 LP-LLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLP--GVNSSS 320

Query: 99  LVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRA 158
             PPP PP  P       P    A   P   +P     F  + R G+    G        
Sbjct: 321 ETPPPLPPKSPS--FQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGG-------G 371

Query: 159 LPRHPPLASERGPRTHTPAPLWQACLVGWVKPQ 191
               PP    R P T   +   QA    W   Q
Sbjct: 372 KLNPPPAPPARSPTTELSSKSQQA--TAWTPTQ 402



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 46/162 (28%), Positives = 59/162 (36%), Gaps = 33/162 (20%)

Query: 32  PPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDLPPRRRSS-----SRSLAR 86
           P PPPPPPP P PPPP   PPP P    A  +   T       P+ RS+      +    
Sbjct: 2   PVPPPPPPPLPPPPPPLGAPPPPPP--SAPPVSTDTSSLRRADPKGRSALLADIQQGTRL 59

Query: 87  GRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSPCSGVTFAG------- 139
            ++TQ    ++P +      +            G A      T P  G  FAG       
Sbjct: 60  RKVTQINDRSAPQIESSKGTN--------KEGGGSANTRGASTPPTLGDLFAGGFPVLRP 111

Query: 140 ---RPRLGQESGQGVAARRRRALPRHP------PLASERGPR 172
              R   G ++GQG  +  R   PR P      PL     PR
Sbjct: 112 AGQRDVAGGKTGQGPGS--RAPSPRLPNKTISGPLIPPASPR 151



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 18/28 (64%), Positives = 18/28 (64%)

Query: 26 VPGTTYPPPPPPPPPTPRPPPPPPLPPP 53
          VP    PP PPPPPP   PPPPPP  PP
Sbjct: 3  VPPPPPPPLPPPPPPLGAPPPPPPSAPP 30



 Score = 28.5 bits (62), Expect = 6.2
 Identities = 15/34 (44%), Positives = 15/34 (44%), Gaps = 7/34 (20%)

Query: 15 MSAQPPSSADTVPGTTYPPPP---PPPPPTPRPP 45
          M   PP      P    PPPP   PPPPP   PP
Sbjct: 1  MPVPPPPPPPLPP----PPPPLGAPPPPPPSAPP 30


>gi|40807465 zinc finger protein 341 [Homo sapiens]
          Length = 847

 Score = 62.4 bits (150), Expect = 4e-10
 Identities = 46/133 (34%), Positives = 58/133 (43%), Gaps = 11/133 (8%)

Query: 12  GPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAP 71
           GPP   Q   +  +VP     PPPPPPPP P PPPPPP PPP P      SL  P  P P
Sbjct: 158 GPP-PVQSSLNMHSVPSYLTQPPPPPPPPPPLPPPPPPQPPPPP----PQSLGPPGRPNP 212

Query: 72  --DLPPRRRSSSRSLARGRITQCQ-VAASPLVPPPAPPHCPRPLLCFLP---AAGPAGLP 125
             +      S++  LA     + Q +   P  P   P  C  P +   P   + G  G  
Sbjct: 213 GGNGVVEVYSAAAPLAGSGTVEIQALGMQPYPPLEVPNQCVEPPVYPTPTVYSPGKQGFK 272

Query: 126 PLRTSPCSGVTFA 138
           P   +P + +T A
Sbjct: 273 PKGPNPAAPMTSA 285


>gi|4557329 fas ligand [Homo sapiens]
          Length = 281

 Score = 61.6 bits (148), Expect = 7e-10
 Identities = 26/41 (63%), Positives = 28/41 (68%), Gaps = 1/41 (2%)

Query: 13 PPMSAQP-PSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPP 52
          PP +  P P+S    PG   PPPPPPPPP P PPPPPPLPP
Sbjct: 25 PPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLPP 65



 Score = 37.0 bits (84), Expect = 0.017
 Identities = 25/56 (44%), Positives = 25/56 (44%), Gaps = 11/56 (19%)

Query: 21 SSADTVPGTTYP-PPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDLPP 75
          SS    PGT  P P   P  P  R PPPP  PPP P        L P  P P LPP
Sbjct: 20 SSPWAPPGTVLPCPTSVPRRPGQRRPPPP--PPPPP--------LPPPPPPPPLPP 65


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score = 61.2 bits (147), Expect = 9e-10
 Identities = 46/139 (33%), Positives = 55/139 (39%), Gaps = 27/139 (19%)

Query: 9   GEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLP----PPGPRLLRACSLL 64
           G   PP    P  +  T+P T  P PPP       PPPPPPLP    PP P L  A  L 
Sbjct: 874 GMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILP 933

Query: 65  LPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAG---- 120
           LP  P   +PP                  +  + + PPP  P    PL   LP AG    
Sbjct: 934 LPPLPGAGIPP---------------PPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPP 978

Query: 121 ----PAGLPPLRTSPCSGV 135
                AG+PP    P +G+
Sbjct: 979 PPLPGAGIPPPPPLPGAGI 997



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 45/138 (32%), Positives = 54/138 (39%), Gaps = 24/138 (17%)

Query: 6    GEGGEAGPPMSAQPPSSADTVPGTTYPPPPP-------PPPPTPRP--PPPPPLP----P 52
            G G    PP+          +P    PPPPP       PPPP P    PPPPPLP    P
Sbjct: 1126 GAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIP 1185

Query: 53   PGPRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPL 112
            P P L        P  P   +PP        +          A +P +PPP     P PL
Sbjct: 1186 PPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGI--------PPAPAPPLPPPGTGIPPPPL 1237

Query: 113  LCFLPAAGPAGLPPLRTS 130
               LP +GP  LP + +S
Sbjct: 1238 ---LPVSGPPLLPQVGSS 1252



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 42/131 (32%), Positives = 49/131 (37%), Gaps = 41/131 (31%)

Query: 6    GEGGEAGPPMSAQPPSSADTVPGTTYPPPPP-------PPPPTPR----PPPPPPLPPPG 54
            G G    PP+          +PG   PPPPP       PPPP P     P P PPLPPPG
Sbjct: 1170 GAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPG 1229

Query: 55   PRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLC 114
              +           P P L P                  V+  PL+P       P P +C
Sbjct: 1230 TGI-----------PPPPLLP------------------VSGPPLLPQVGSSTLPTPQVC 1260

Query: 115  -FLPAAGPAGL 124
             FLP   P+GL
Sbjct: 1261 GFLPPPLPSGL 1271



 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 54/176 (30%), Positives = 64/176 (36%), Gaps = 28/176 (15%)

Query: 6    GEGGEAGPPMSAQPPSSADTVPGTTYPPPPP-------PPPPTPRP--PPPPPLP----P 52
            G G    PP+          +PG   PPPPP       PPPP P    PPPPPLP    P
Sbjct: 1016 GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1075

Query: 53   PGPRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPL 112
            P P L  A     P  P   +PP        +         +  + + PPP  P    P 
Sbjct: 1076 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIP----PPPPLPGAGIPPPPPLPGAGIPP 1131

Query: 113  LCFLPAAG---PAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPL 165
               LP AG   P  LP +   P   +  AG P      G G+        P  PPL
Sbjct: 1132 PPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGI--------PPPPPL 1179



 Score = 52.0 bits (123), Expect = 5e-07
 Identities = 45/143 (31%), Positives = 52/143 (36%), Gaps = 20/143 (13%)

Query: 6    GEGGEAGPPMSAQPPSSADTVPGTTYPPPPP-------PPPPTPRP--PPPPPLP----P 52
            G G    PP+          +PG   PPPPP       PPPP P    PPPPPLP    P
Sbjct: 1049 GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIP 1108

Query: 53   PGPRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPL 112
            P P L  A     P  P   +PP        +             P V  P PP  P   
Sbjct: 1109 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP-------PPPPLPRVGIPPPPPLPGAG 1161

Query: 113  LCFLPAAGPAGLPPLRTSPCSGV 135
            +   P    AG+PP    P  G+
Sbjct: 1162 IPPPPPLPGAGIPPPPPLPGVGI 1184



 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 46/151 (30%), Positives = 56/151 (37%), Gaps = 25/151 (16%)

Query: 6    GEGGEAGPPMSAQPPSSADTVPGTTYPPPP-------PPPPPTPRP--PPPPPLP----P 52
            G G    PP+          +PG   PPPP       PPPPP P    P PPPLP    P
Sbjct: 917  GAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIP 976

Query: 53   PGPRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPL 112
            P P L  A     P  P   +PP        +         +  + + PPP  P    P 
Sbjct: 977  PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP----PPPPLPGAGIPPPPPLPGAGIPP 1032

Query: 113  LCFLPAAG--------PAGLPPLRTSPCSGV 135
               LP AG         AG+PP    P +G+
Sbjct: 1033 PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1063



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 56/189 (29%), Positives = 63/189 (33%), Gaps = 44/189 (23%)

Query: 6    GEGGEAGPPMSAQ--PPSSADTVPGTTYPP-------PPPPPPPTPRPPPPPPLP----P 52
            G G    PP+     PP       G   PP       PPPPP P    PPPPPLP    P
Sbjct: 994  GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1053

Query: 53   PGPRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPL 112
            P P L  A     P  P   +PP                  +  + + PPP  P    P 
Sbjct: 1054 PPPPLPGAGIPPPPPLPGAGIPP---------------PPPLPGAGIPPPPPLPGAGIPP 1098

Query: 113  LCFLPAAG---PAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASER 169
               LP  G   P  LP     P   +  AG P      G G+        P  PPL    
Sbjct: 1099 PPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI--------PPPPPL---- 1146

Query: 170  GPRTHTPAP 178
             PR   P P
Sbjct: 1147 -PRVGIPPP 1154



 Score = 38.1 bits (87), Expect = 0.008
 Identities = 41/143 (28%), Positives = 51/143 (35%), Gaps = 64/143 (44%)

Query: 17  AQPPSSADTVPGTTYP-------------PPPPPPPPTPR----------PPPPPPLPPP 53
           +QPP S  T   T++              P PPP P T            PPPPPPLP  
Sbjct: 827 SQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLP-- 884

Query: 54  GPRLLRACSLLLPTEPA---PDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPP---- 106
                    + +PT P+   P  PP                  +  + ++PPP PP    
Sbjct: 885 --------GMTVPTLPSTAIPQPPP------------------LQGTEMLPPPPPPLPGA 918

Query: 107 --HCPRPLLCFLPAAGPAGLPPL 127
               P P    LP AG   LPPL
Sbjct: 919 GIPPPPP----LPGAGILPLPPL 937



 Score = 28.5 bits (62), Expect = 6.2
 Identities = 19/59 (32%), Positives = 25/59 (42%), Gaps = 4/59 (6%)

Query: 1   MGKAGGEGGEAGPPMSAQPPSSADTVP-GTTYPPPPPPPPPTPRPPP---PPPLPPPGP 55
           +G +GG G   G P + Q  S+   +P      P  P  PP+P   P    P LP   P
Sbjct: 254 LGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPSLPAAQP 312


>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
          Length = 1240

 Score = 61.2 bits (147), Expect = 9e-10
 Identities = 40/109 (36%), Positives = 46/109 (42%), Gaps = 9/109 (8%)

Query: 32  PPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGRITQ 91
           PPPPPPPP  P     PP PPP P L    +  LPT P P  PP     + +     +  
Sbjct: 421 PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPP--PPLPGLGAMAPPAPPLPP 478

Query: 92  CQVAASPLVPPPAPP----HCPRPLLCFLPAAG---PAGLPPLRTSPCS 133
               +   +PPP PP     CP P    LP  G   P   PPL    CS
Sbjct: 479 PLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCS 527



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 40/120 (33%), Positives = 44/120 (36%), Gaps = 27/120 (22%)

Query: 9   GEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPT---PRPPPPPPLPPPGPRLLRACSLLL 65
           G +  P    PP    +V     P  PPPPP        PP PPLPPP P    +C  L 
Sbjct: 432 GSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLP---GSCEFLP 488

Query: 66  PTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVP-----PPAPPHCPRPLLCFLPAAG 120
           P  P P LP                 C     PL+P     PP PP    P  C  P AG
Sbjct: 489 P--PPPPLPG--------------LGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAG 532



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 30/78 (38%), Positives = 31/78 (39%), Gaps = 20/78 (25%)

Query: 5   GGEGGEAGPPMSAQPPSSADTVPGTTYPPP--------PPPPPPTPR---PPPPPPL--- 50
           G +     PP    P   A   P    PPP        PPPPPP P    PPPPPPL   
Sbjct: 450 GAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPG 509

Query: 51  ------PPPGPRLLRACS 62
                 PPP P L   CS
Sbjct: 510 MGWGPPPPPPPLLPCTCS 527



 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 32/92 (34%), Positives = 32/92 (34%), Gaps = 23/92 (25%)

Query: 6   GEGGEAGPPMSAQPPSSADTVPGTTYPPPPP-------PPPPTPRPPP---------PPP 49
           G   E  PP    P  S       T PPPPP        PP  P PPP         PPP
Sbjct: 432 GSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPP 491

Query: 50  -------LPPPGPRLLRACSLLLPTEPAPDLP 74
                   PPP P LL       P  P P LP
Sbjct: 492 PPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLP 523


>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
          Length = 1249

 Score = 61.2 bits (147), Expect = 9e-10
 Identities = 40/109 (36%), Positives = 46/109 (42%), Gaps = 9/109 (8%)

Query: 32  PPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGRITQ 91
           PPPPPPPP  P     PP PPP P L    +  LPT P P  PP     + +     +  
Sbjct: 421 PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPP--PPLPGLGAMAPPAPPLPP 478

Query: 92  CQVAASPLVPPPAPP----HCPRPLLCFLPAAG---PAGLPPLRTSPCS 133
               +   +PPP PP     CP P    LP  G   P   PPL    CS
Sbjct: 479 PLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCS 527



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 40/120 (33%), Positives = 44/120 (36%), Gaps = 27/120 (22%)

Query: 9   GEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPT---PRPPPPPPLPPPGPRLLRACSLLL 65
           G +  P    PP    +V     P  PPPPP        PP PPLPPP P    +C  L 
Sbjct: 432 GSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLP---GSCEFLP 488

Query: 66  PTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVP-----PPAPPHCPRPLLCFLPAAG 120
           P  P P LP                 C     PL+P     PP PP    P  C  P AG
Sbjct: 489 P--PPPPLPG--------------LGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAG 532



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 30/78 (38%), Positives = 31/78 (39%), Gaps = 20/78 (25%)

Query: 5   GGEGGEAGPPMSAQPPSSADTVPGTTYPPP--------PPPPPPTPR---PPPPPPL--- 50
           G +     PP    P   A   P    PPP        PPPPPP P    PPPPPPL   
Sbjct: 450 GAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPG 509

Query: 51  ------PPPGPRLLRACS 62
                 PPP P L   CS
Sbjct: 510 MGWGPPPPPPPLLPCTCS 527



 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 32/92 (34%), Positives = 32/92 (34%), Gaps = 23/92 (25%)

Query: 6   GEGGEAGPPMSAQPPSSADTVPGTTYPPPPP-------PPPPTPRPPP---------PPP 49
           G   E  PP    P  S       T PPPPP        PP  P PPP         PPP
Sbjct: 432 GSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPP 491

Query: 50  -------LPPPGPRLLRACSLLLPTEPAPDLP 74
                   PPP P LL       P  P P LP
Sbjct: 492 PPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLP 523


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score = 60.5 bits (145), Expect = 1e-09
 Identities = 57/166 (34%), Positives = 64/166 (38%), Gaps = 29/166 (17%)

Query: 4   AGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLL----R 59
           A G GG  G    A P       PG   PPPPP PP    PPPPPP PPPGP        
Sbjct: 3   ARGGGGRPGESPGATP------APGPP-PPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHP 55

Query: 60  ACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPP------------PAPPH 107
             +  LP E A +  PR R  SR  + GR      A++    P            PA P 
Sbjct: 56  PRAEALPPEAADEGGPRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPE 115

Query: 108 CPR-----PLLCFLPAAGPA-GLPPLRTSPCSGVTFAGRPRLGQES 147
            P         C   A+GPA G  P   +       AG PR  Q S
Sbjct: 116 GPARGPKVSFSCRGAASGPAPGPGPAEEAGSEEAGPAGEPRGSQAS 161



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 38/99 (38%), Positives = 42/99 (42%), Gaps = 19/99 (19%)

Query: 33  PPPPPPPPTPRPPPPPPLPPPG----PRLLRACSL-LLPTEP--APDLPPRRRS-SSRSL 84
           PPP P P    P PPPP  PPG    PR  R      LP  P   P LP RR S +SR L
Sbjct: 761 PPPGPAPAAASPGPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPL 820

Query: 85  ARGRITQCQVAASPLVP--PPAPPHCPRPLLCFLPAAGP 121
           +         A+ P +P   P P    RP     P  GP
Sbjct: 821 S---------ASQPSLPHGAPGPAASTRPASSSTPRLGP 850



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 51/160 (31%), Positives = 59/160 (36%), Gaps = 24/160 (15%)

Query: 31  YPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSL-LLPTEPAPDLPPRRRSSSRSLARGRI 89
           +PPPPPPP  T               L +A ++   P    P + P    S R + R   
Sbjct: 714 FPPPPPPPQVTSAI----------ATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPP 763

Query: 90  TQCQVAASPLVPP-------PAPPHCPRPL----LCFLPAAGPAGLPPLRTSPCSGVTFA 138
                AASP  PP       PA P  PR      L   P AGPA LP  R S  S    A
Sbjct: 764 GPAPAAASPGPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPA-LPARRLSRASRPLSA 822

Query: 139 GRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAP 178
            +P L      G AA  R A    P L      R   P+P
Sbjct: 823 SQPSL-PHGAPGPAASTRPASSSTPRLGPTPAARAAAPSP 861



 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 42/153 (27%), Positives = 45/153 (29%), Gaps = 36/153 (23%)

Query: 24  DTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDLPPRRRSSSRS 83
           D   G   P   P   P P PPPPPP  PP              +P P  PP        
Sbjct: 2   DARGGGGRPGESPGATPAPGPPPPPPPAPP------------QQQPPPPPPP-------- 41

Query: 84  LARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAA----GPAGLPPLRTSPCSGVTFAG 139
                       A P  P PAPP  P       P A    GP G    R S C      G
Sbjct: 42  ------------APPPGPGPAPPQHPPRAEALPPEAADEGGPRGRLRSRDSSCGRPGTPG 89

Query: 140 RPRLGQESGQGVAARRRRALPRHPPLASERGPR 172
                + S  G   R         P    RGP+
Sbjct: 90  AASTAKGSPNGECGRGEPQCSPAGPEGPARGPK 122



 Score = 33.5 bits (75), Expect = 0.19
 Identities = 48/165 (29%), Positives = 56/165 (33%), Gaps = 14/165 (8%)

Query: 99  LVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSPCSGVTFAGRPRLGQESGQG---VAARR 155
           L PPP PP      +  L  A      P    P  G    G PRL +    G    AA  
Sbjct: 713 LFPPPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASP 772

Query: 156 RRALPRHPP--LASERGPRTHTPAPLWQACLVGWVKP--QCVHTERRGAVERGS---GLA 208
               P  PP   AS R PRT     L  A L G   P  +     R  +  + S   G  
Sbjct: 773 GPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQPSLPHGAP 832

Query: 209 EEDADQAPATQGNSEL---PRAALRVSEENRGDGRNMG-EGGLFP 249
              A   PA+     L   P A       +R D  + G  GGL P
Sbjct: 833 GPAASTRPASSSTPRLGPTPAARAAAPSPDRRDSASPGAAGGLDP 877


>gi|60460889 Myb protein P42POP [Homo sapiens]
          Length = 399

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 57/185 (30%), Positives = 67/185 (36%), Gaps = 32/185 (17%)

Query: 7   EGGEAGPPMSAQPPSSA---DTVPGTTYPPPPPPPPPTPRPP-----PPPPLPPPGPRLL 58
           EGG   P     PP SA     +P     PPPP PP  P PP     P PP PPP PR  
Sbjct: 191 EGGCPRPKERESPPPSALQPVQLPRLALSPPPPAPPLPPPPPLAQVAPSPPSPPPPPRPP 250

Query: 59  RACSLLLPTEPAPDLPPRRRSSSRSLA---RGRITQCQVAAS----------------PL 99
              S   P+           ++ R LA   R  + +   A S                PL
Sbjct: 251 PTLSASDPSLDFLRAQQETANAIRELAGTLRQGLAKLSEALSALLPLLPGTPVDSLPPPL 310

Query: 100 VPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRAL 159
            PPP PP  PRP+L       PA    +   P S V       +    G  +A R     
Sbjct: 311 PPPPPPPPPPRPVL-----PPPAPKVEITPEPVSVVAAVVDGAVVAARGVIIAPRSEEGA 365

Query: 160 PRHPP 164
           PR PP
Sbjct: 366 PRPPP 370



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 34/108 (31%), Positives = 46/108 (42%), Gaps = 27/108 (25%)

Query: 26  VPGTTYP--PPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDLPPRRRSSSRS 83
           +PGT     PPP PPPP P PPP P LPPP P++              ++ P   S   +
Sbjct: 298 LPGTPVDSLPPPLPPPPPPPPPPRPVLPPPAPKV--------------EITPEPVSVVAA 343

Query: 84  LARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSP 131
           +  G +     A   ++ P +    PRP         PA LPP  + P
Sbjct: 344 VVDGAVV---AARGVIIAPRSEEGAPRP--------PPAPLPPHDSPP 380



 Score = 45.1 bits (105), Expect = 6e-05
 Identities = 30/95 (31%), Positives = 39/95 (41%), Gaps = 15/95 (15%)

Query: 19  PPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDLPPRRR 78
           P +  D++P    PPPPPPPPP P  PPP P     P  +   + ++             
Sbjct: 299 PGTPVDSLPPPLPPPPPPPPPPRPVLPPPAPKVEITPEPVSVVAAVV------------- 345

Query: 79  SSSRSLARGRITQCQVAASPLVPPPA--PPHCPRP 111
             +   ARG I   +       PPPA  PPH   P
Sbjct: 346 DGAVVAARGVIIAPRSEEGAPRPPPAPLPPHDSPP 380



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 37/131 (28%), Positives = 47/131 (35%), Gaps = 32/131 (24%)

Query: 27  PGTTYPPPPPPPPPTPRPPPPPPLP--------------------------PPGPRLLRA 60
           PG       PP  P+ +PPPP   P                           P P    +
Sbjct: 127 PGAGAGAEEPPAAPSSQPPPPSACPQRYVLSEDRREDRRADTSAHSKAGSSSPEPWARPS 186

Query: 61  CSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAG 120
           C+   P E     P  R S   S A   +   ++A SP  PPPAPP  P P L  +  + 
Sbjct: 187 CT---PQEGGCPRPKERESPPPS-ALQPVQLPRLALSP--PPPAPPLPPPPPLAQVAPSP 240

Query: 121 PAGLPPLRTSP 131
           P+  PP R  P
Sbjct: 241 PSPPPPPRPPP 251


>gi|126090663 zinc finger homeodomain 4 [Homo sapiens]
          Length = 3571

 Score = 59.3 bits (142), Expect = 3e-09
 Identities = 31/71 (43%), Positives = 37/71 (52%), Gaps = 18/71 (25%)

Query: 14   PMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPA--- 70
            P+ A PP+          PPPPPPPPP P PPPPPP P   P++    SL LP  P+   
Sbjct: 1989 PLQAPPPT----------PPPPPPPPPPPPPPPPPPPPSAPPQVQLPVSLDLPLFPSIMM 2038

Query: 71   -----PDLPPR 76
                 P LPP+
Sbjct: 2039 QPVQHPALPPQ 2049



 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 37/115 (32%), Positives = 42/115 (36%), Gaps = 34/115 (29%)

Query: 20   PSSADTVPGTTYPPPPPP-----------------------PPPTPRPPPPPPLPPPGPR 56
            PSS +T P    PPP PP                       PPPTP PPPPPP PPP P 
Sbjct: 1952 PSSPETPPPPPPPPPLPPAPPQPSSMGPVKIPNTVSTPLQAPPPTPPPPPPPPPPPPPP- 2010

Query: 57   LLRACSLLLPTEPAPDLPPR-RRSSSRSLARGRITQCQVAASPLVPPPAPPHCPR 110
                     P  P P  PP+ +   S  L        Q    P +PP      P+
Sbjct: 2011 ---------PPPPPPSAPPQVQLPVSLDLPLFPSIMMQPVQHPALPPQLALQLPQ 2056



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 34/103 (33%), Positives = 37/103 (35%), Gaps = 23/103 (22%)

Query: 31   YPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGRIT 90
            YP  P  P   P PPPPPPLPP  P+         P+   P   P   S+          
Sbjct: 1948 YPISPSSPETPPPPPPPPPLPPAPPQ---------PSSMGPVKIPNTVSTPLQ------- 1991

Query: 91   QCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSPCS 133
                A  P  PPP PP  P P     P   P   PP    P S
Sbjct: 1992 ----APPPTPPPPPPPPPPPPP---PPPPPPPSAPPQVQLPVS 2027



 Score = 37.4 bits (85), Expect = 0.013
 Identities = 18/39 (46%), Positives = 21/39 (53%), Gaps = 1/39 (2%)

Query: 20   PSSADTVPGTTYPPPPPPPP-PTPRPPPPPPLPPPGPRL 57
            P+SA + P  +    P  P   TP PPPPPP PPP   L
Sbjct: 3094 PTSATSSPALSLSSAPTKPLLQTPPPPPPPPPPPPSSSL 3132



 Score = 35.8 bits (81), Expect = 0.039
 Identities = 20/43 (46%), Positives = 21/43 (48%), Gaps = 5/43 (11%)

Query: 9    GEAGPPMSA--QPPSSADTVPGTTYPPPPPPPPPTPRPPPPPP 49
            G  G P SA   P  S  + P       PPPPPP   PPPPPP
Sbjct: 3089 GMLGFPTSATSSPALSLSSAPTKPLLQTPPPPPP---PPPPPP 3128



 Score = 30.4 bits (67), Expect = 1.6
 Identities = 31/120 (25%), Positives = 47/120 (39%), Gaps = 16/120 (13%)

Query: 16   SAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDLPP 75
            +A P +S+ +   T   P P P P    P P  P   P             ++P+P  P 
Sbjct: 2331 AAAPAASSGSGTSTPLIPSPKPEPEKTSPKPEYPAEKP-----------KQSDPSP--PS 2377

Query: 76   RRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLP--PLRTSPCS 133
            +    +  LA       Q + +   P P PP  P+ L+   P+A    +P  PL+ S  S
Sbjct: 2378 QGTKPALPLASTSSDPPQASTAQPQPQPQPPKQPQ-LIGRPPSASQTPVPSSPLQISMTS 2436



 Score = 29.3 bits (64), Expect = 3.6
 Identities = 26/96 (27%), Positives = 38/96 (39%), Gaps = 13/96 (13%)

Query: 13   PPMSAQPPSSADTVPGT--TYPPPP------PPPPPTPRPPPPPPLPPPGPRLL----RA 60
            P   A+ P  +D  P +  T P  P       PP  +   P P P PP  P+L+     A
Sbjct: 2361 PEYPAEKPKQSDPSPPSQGTKPALPLASTSSDPPQASTAQPQPQPQPPKQPQLIGRPPSA 2420

Query: 61   CSLLLPTEPAP-DLPPRRRSSSRSLARGRITQCQVA 95
                +P+ P    +   + S    L + +  QC VA
Sbjct: 2421 SQTPVPSSPLQISMTSLQNSLPPQLLQYQCDQCTVA 2456


>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
          Length = 1271

 Score = 59.3 bits (142), Expect = 3e-09
 Identities = 44/134 (32%), Positives = 52/134 (38%), Gaps = 18/134 (13%)

Query: 2   GKAGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRAC 61
           G A  +G    PP   + P+ +           P PPPP P PPPPPP PPP P LL   
Sbjct: 4   GAAAAQG--TAPPQDGEQPAES-----------PEPPPPWP-PPPPPPAPPPAPPLLSEA 49

Query: 62  SLLLPTEPAPDLP----PRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLP 117
           S     EP P+L     P   S S +      T          P P P   P P     P
Sbjct: 50  SPEPIPEPCPELAPGPCPEATSESATELYTEPTPEPATEPASEPAPEPATEPAPEPATEP 109

Query: 118 AAGPAGLPPLRTSP 131
           A  PA  P   ++P
Sbjct: 110 APEPAPEPATESAP 123



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 35/125 (28%), Positives = 42/125 (33%), Gaps = 17/125 (13%)

Query: 14  PMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPP-------PLPPPGPRLLRACSLLLP 66
           P  A  P+S       T P P P   P P P P P       P P P    +   +  L 
Sbjct: 83  PEPATEPASEPAPEPATEPAPEPATEPAPEPAPEPATESAPEPTPEPALESVPEPAPELT 142

Query: 67  TEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPP 126
            E AP+L P             +T+    A    P  AP   P P  C L          
Sbjct: 143 PEVAPELAPEPTPEP-------VTE---LAPEFCPEAAPEFRPSPAPCLLQCPVDTRERG 192

Query: 127 LRTSP 131
           L+TSP
Sbjct: 193 LKTSP 197



 Score = 35.0 bits (79), Expect = 0.066
 Identities = 29/107 (27%), Positives = 35/107 (32%), Gaps = 6/107 (5%)

Query: 10  EAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPP--LPPPGPRLLRACSLLLPT 67
           E  P  + +P       P T   P P P P     P P P   P   P L    +    T
Sbjct: 100 EPAPEPATEPAPEPAPEPATESAPEPTPEPALESVPEPAPELTPEVAPELAPEPTPEPVT 159

Query: 68  EPAPDLPPRRRSSSRSLARGRITQCQV----AASPLVPPPAPPHCPR 110
           E AP+  P      R      + QC V          P P+P   PR
Sbjct: 160 ELAPEFCPEAAPEFRPSPAPCLLQCPVDTRERGLKTSPSPSPSPSPR 206



 Score = 33.1 bits (74), Expect = 0.25
 Identities = 38/147 (25%), Positives = 39/147 (26%), Gaps = 49/147 (33%)

Query: 33  PPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGRITQC 92
           PP     P   P PPPP PPP                                       
Sbjct: 13  PPQDGEQPAESPEPPPPWPPPP-------------------------------------- 34

Query: 93  QVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSPCSGVTFAGRPRLGQESGQGVA 152
                   PPPAPP  P  L    P   P   P L   PC   T      L  E     A
Sbjct: 35  --------PPPAPPPAPPLLSEASPEPIPEPCPELAPGPCPEATSESATELYTEPTPEPA 86

Query: 153 ARRRRALPRHPPLASERGPRTHT-PAP 178
                A    P  A+E  P   T PAP
Sbjct: 87  T--EPASEPAPEPATEPAPEPATEPAP 111


>gi|33356148 formin-like 1 [Homo sapiens]
          Length = 1100

 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 27/50 (54%), Positives = 29/50 (58%), Gaps = 7/50 (14%)

Query: 13  PPMSAQP-PSSADTVPGTTYPPPPPPPP------PTPRPPPPPPLPPPGP 55
           PP+   P P  A  +PG   PPPPPPPP      P P PPPPPP PP GP
Sbjct: 566 PPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGP 615



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 28/64 (43%), Positives = 31/64 (48%), Gaps = 8/64 (12%)

Query: 14  PMSAQP--PSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAP 71
           P  A P  P  A  +PG+  PPP PP P    PPPPPP PPPG          +P  P P
Sbjct: 554 PQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPG------TDGPVPPPPPP 607

Query: 72  DLPP 75
             PP
Sbjct: 608 PPPP 611



 Score = 52.0 bits (123), Expect = 5e-07
 Identities = 50/161 (31%), Positives = 60/161 (37%), Gaps = 47/161 (29%)

Query: 4   AGGEGGEAGPPMSAQPPS---SADTVPGTTYPPPPP-PPPPTPR--PPPPPPLPPPGPRL 57
           +GG+    G P  +  P    +A+  PG   PPPPP P  P+P+  PP  PP  PP    
Sbjct: 512 SGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPP---- 567

Query: 58  LRACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPL---VPPPAPPHCPRPLLC 114
                  LP  P P  PP                    A PL   +PPP PP  P P   
Sbjct: 568 -------LPGSPEP--PP--------------------APPLPGDLPPPPPPPPPPP--- 595

Query: 115 FLPAAGPAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARR 155
                GP   PP    P  G       R   E G GV A++
Sbjct: 596 --GTDGPVPPPPPPPPPPPGGPPDALGRRDSELGPGVKAKK 634


>gi|11386183 WAS protein family, member 2 [Homo sapiens]
          Length = 498

 Score = 58.2 bits (139), Expect = 7e-09
 Identities = 44/128 (34%), Positives = 52/128 (40%), Gaps = 27/128 (21%)

Query: 13  PPMSAQPPSSADTVPGTTYPPPPPPPPP--TPRPPPPPPL--------PPPGPRLLRACS 62
           PP+ + P       PG   PP PPPPPP     PPPPPP+        PPP P       
Sbjct: 304 PPLGSPPGPK----PGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPP------ 353

Query: 63  LLLPTEP----APDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPA 118
              P  P     P  PP   +   +L    ++Q    A P  PPP PP  P P   F  A
Sbjct: 354 -SFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPP--PFTGA 410

Query: 119 AGPAGLPP 126
            G   +PP
Sbjct: 411 DGQPAIPP 418



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 55/175 (31%), Positives = 64/175 (36%), Gaps = 33/175 (18%)

Query: 9   GEAGPPMSAQ-PPSSADTVPGTTYPPPPPP---PPPTPRPPPPP--PLPPPGPRLLRACS 62
           G AGP  S+   PS     P    PP P P   PPP P PPPPP   +PPP P +     
Sbjct: 285 GLAGPKRSSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSP 344

Query: 63  LLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPA 122
              P    P  PP                   AA P  PPP PP    P L   P + P 
Sbjct: 345 GTPPPPSPPSFPPHP---------------DFAAPP--PPPPPPAADYPTLPPPPLSQPT 387

Query: 123 GLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPA 177
           G  P    P         P  G        A  + A+P  PPL+    P++  PA
Sbjct: 388 GGAPPPPPP--------PPPPGPPPPPFTGADGQPAIP--PPLSDTTKPKSSLPA 432


>gi|156523244 membrane-associated ring finger (C3HC4) 11 [Homo
           sapiens]
          Length = 402

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 47/132 (35%), Positives = 55/132 (41%), Gaps = 15/132 (11%)

Query: 28  GTTYPPPPPPPPPTPRPPPPPPLP-PPGPRLLRACSLLLPTEPAPDLPPRRRSSSRSLAR 86
           G   PPP PPPPP P PPP  P P P  PR L       P   +P+ P R    S  L  
Sbjct: 18  GDAEPPPQPPPPPPPTPPPGEPAPVPAAPRYLP------PLPASPETPERAAGPSEPL-- 69

Query: 87  GRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSPCSGVTFAGRPRLGQE 146
           G +      A  L PPP P    +P    + AAG +G  P R    +     G P    E
Sbjct: 70  GEVAPRCRGADELPPPPLP---LQPAGQEVAAAGDSGEGPRRLPEAAAA--KGGPG-ESE 123

Query: 147 SGQGVAARRRRA 158
           +G G    RR A
Sbjct: 124 AGAGGERERRGA 135


>gi|169163027 PREDICTED: similar to Putative acrosin-like protease
           [Homo sapiens]
          Length = 355

 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 24/42 (57%), Positives = 30/42 (71%), Gaps = 3/42 (7%)

Query: 14  PMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGP 55
           P+  +PP++    P +  PPPPPPPPP+P PPPPPP PPP P
Sbjct: 268 PLPPRPPAAQPRPPPS--PPPPPPPPPSPLPPPPPP-PPPTP 306



 Score = 48.5 bits (114), Expect = 6e-06
 Identities = 21/37 (56%), Positives = 21/37 (56%), Gaps = 1/37 (2%)

Query: 19  PPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGP 55
           PP      P    P PPP PPP P PPPP PLPPP P
Sbjct: 265 PPRPLPPRPPAAQPRPPPSPPPPP-PPPPSPLPPPPP 300



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 29/74 (39%), Positives = 32/74 (43%), Gaps = 11/74 (14%)

Query: 14  PMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDL 73
           P+SA  P      P    P PP   P  P  PPPPP PPP P         LP  P P  
Sbjct: 253 PLSAHLPWYFQPPPRPLPPRPPAAQPRPPPSPPPPPPPPPSP---------LPPPPPP-- 301

Query: 74  PPRRRSSSRSLARG 87
           PP   SS+  L +G
Sbjct: 302 PPPTPSSTTKLPQG 315



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 36/105 (34%), Positives = 39/105 (37%), Gaps = 20/105 (19%)

Query: 37  PPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAA 96
           PPPPT RPPP   + PP    L A        P   LPPR                  AA
Sbjct: 236 PPPPTTRPPP---IRPPFSHPLSAHLPWYFQPPPRPLPPR----------------PPAA 276

Query: 97  SPLVPP-PAPPHCPRPLLCFLPAAGPAGLPPLRTSPCSGVTFAGR 140
            P  PP P PP  P P     P   P   P   T    G++FA R
Sbjct: 277 QPRPPPSPPPPPPPPPSPLPPPPPPPPPTPSSTTKLPQGLSFAKR 321



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 30/95 (31%), Positives = 31/95 (32%), Gaps = 37/95 (38%)

Query: 26  VPGTTYPPPPPPPPPTPRP--------------PPPPPLPPPGPRLLRACSLLLPTEPAP 71
           +   T PPP   PPP   P              PPP PLPP  P    A     P  P P
Sbjct: 231 IQSATPPPPTTRPPPIRPPFSHPLSAHLPWYFQPPPRPLPPRPP----AAQPRPPPSPPP 286

Query: 72  DLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPP 106
             PP                     SPL PPP PP
Sbjct: 287 PPPP-------------------PPSPLPPPPPPP 302



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 17/30 (56%), Positives = 18/30 (60%), Gaps = 3/30 (10%)

Query: 13  PPMSAQPPSSADTVPGTTYPPPPPPPPPTP 42
           PP S  PP      P +  PPPPPPPPPTP
Sbjct: 280 PPPSPPPPPPP---PPSPLPPPPPPPPPTP 306


>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 54/174 (31%), Positives = 66/174 (37%), Gaps = 31/174 (17%)

Query: 13  PPMSAQPPSSADTVPGTTYPPPP----PPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTE 68
           PP+  +P    + VP    PPPP    PP P TPRP      PPP P          P+ 
Sbjct: 269 PPVGNRPSIHREAVP----PPPPQNNKPPVPSTPRPSASSQAPPPPPP---------PSR 315

Query: 69  PAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLR 128
           P P  PP   SSS +    R+ Q  ++ S   PP   P    PL    P       PP+R
Sbjct: 316 PGP--PPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPL---PPPPSERPPPPVR 370

Query: 129 TSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERG---PRTHTPAPL 179
             P         P + +           RALP  P L S  G   PR+    PL
Sbjct: 371 DPPGRSGPLPPPPPVSRNGSTS------RALPATPQLPSRSGVDSPRSGPRPPL 418



 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 54/173 (31%), Positives = 69/173 (39%), Gaps = 35/173 (20%)

Query: 13  PPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPD 72
           PP + +PP  +   P  +   PPPPPPP+   P PPPLPP               +  P 
Sbjct: 286 PPQNNKPPVPSTPRPSASSQAPPPPPPPS--RPGPPPLPPSSS----------GNDETPR 333

Query: 73  LPPRRRSSSRSL----ARGRITQCQVAASPLVPPPA---PPHCPRPLLCFLPAAGPAGLP 125
           LP R  S S S     + GR       + PL PPP+   PP    P     P   P   P
Sbjct: 334 LPQRNLSLSSSTPPLPSPGR-------SGPLPPPPSERPPPPVRDPPGRSGPLPPP---P 383

Query: 126 PLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAP 178
           P+  +  +       P+L   SG        R+ PR PPL  +R P    P P
Sbjct: 384 PVSRNGSTSRALPATPQLPSRSG----VDSPRSGPR-PPLPPDR-PSAGAPPP 430



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 38/122 (31%), Positives = 45/122 (36%), Gaps = 22/122 (18%)

Query: 5   GGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLL 64
           G  G   G     Q P S+ + P +  PP PP P       PPPP PP G R       +
Sbjct: 224 GNRGTALGGGSIRQSPLSSSS-PFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAV 282

Query: 65  LPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGL 124
            P  P  + PP   +   S           A+S   PPP PP  P          GP  L
Sbjct: 283 PPPPPQNNKPPVPSTPRPS-----------ASSQAPPPPPPPSRP----------GPPPL 321

Query: 125 PP 126
           PP
Sbjct: 322 PP 323



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 26/72 (36%), Positives = 29/72 (40%), Gaps = 22/72 (30%)

Query: 6   GEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPP-----------PPTPRPP--------- 45
           G  G   PP S +PP      PG + P PPPPP           P TP+ P         
Sbjct: 352 GRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPR 411

Query: 46  --PPPPLPPPGP 55
             P PPLPP  P
Sbjct: 412 SGPRPPLPPDRP 423



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 38/132 (28%), Positives = 52/132 (39%), Gaps = 23/132 (17%)

Query: 8   GGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPT 67
           G +  P +  +  S + + P    P    P PP P   PPPP+  P  R          +
Sbjct: 327 GNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGR----------S 376

Query: 68  EPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPR-----PLLCFLPAAGPA 122
            P P  PP  R+ S S A        + A+P +P  +    PR     PL    P+AG  
Sbjct: 377 GPLPPPPPVSRNGSTSRA--------LPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAP 428

Query: 123 GLPPLRTSPCSG 134
             PP  TS  +G
Sbjct: 429 PPPPPSTSIRNG 440



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 46/170 (27%), Positives = 57/170 (33%), Gaps = 32/170 (18%)

Query: 13  PPMSAQPPSSADTVPGTTYPPPP-------PPPPPTPRPPPPPPLPPPGPRLLRAC---- 61
           P + ++P S    VP T  P          PP P  PR P P P PPP P          
Sbjct: 174 PDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGG 233

Query: 62  ----SLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLP 117
               S L  + P  + PP   + SR+L                PPP PP   RP +    
Sbjct: 234 SIRQSPLSSSSPFSNRPPLPPTPSRAL------------DDKPPPPPPPVGNRPSIHREA 281

Query: 118 AAGPAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLAS 167
              P   PP    P   V    RP    ++        R   P  PP +S
Sbjct: 282 VPPP---PPQNNKP--PVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSS 326



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 47/180 (26%), Positives = 59/180 (32%), Gaps = 41/180 (22%)

Query: 5   GGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPP-----PPLPPPGPRLLR 59
           G   G   P  +  PP   D        PPP P  P P    P     PP+ P GPR   
Sbjct: 156 GHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPV-PGGPR--- 211

Query: 60  ACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQV-AASPLVPPPAPPHCPRPLLCFLPA 118
                    P P  PP   +   +L  G I Q  + ++SP    P  P  P   L   P 
Sbjct: 212 ------QPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP 265

Query: 119 AGPAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAP 178
             P   PP+   P                     +  R A+P  PP  + + P   TP P
Sbjct: 266 PPP---PPVGNRP---------------------SIHREAVPPPPP-QNNKPPVPSTPRP 300



 Score = 33.9 bits (76), Expect = 0.15
 Identities = 39/134 (29%), Positives = 50/134 (37%), Gaps = 6/134 (4%)

Query: 48  PPLPPPGPRLLRACSLLLPTEPA--PDLPPRRRSSSRSLARGRI--TQCQVAASPLVPPP 103
           PPL PPG R   A     P+ P   P   P  RS      R R+   +  V + P   PP
Sbjct: 126 PPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPP 185

Query: 104 APPHCPRPLLCFLPAAGPAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHP 163
             P  PRP+       G   +P     P  G T    P   + +  G  + R+  L    
Sbjct: 186 PVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPG-NRGTALGGGSIRQSPLSSSS 244

Query: 164 PLASERGPRTHTPA 177
           P  S R P   TP+
Sbjct: 245 PF-SNRPPLPPTPS 257


>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 54/174 (31%), Positives = 66/174 (37%), Gaps = 31/174 (17%)

Query: 13  PPMSAQPPSSADTVPGTTYPPPP----PPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTE 68
           PP+  +P    + VP    PPPP    PP P TPRP      PPP P          P+ 
Sbjct: 269 PPVGNRPSIHREAVP----PPPPQNNKPPVPSTPRPSASSQAPPPPPP---------PSR 315

Query: 69  PAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLR 128
           P P  PP   SSS +    R+ Q  ++ S   PP   P    PL    P       PP+R
Sbjct: 316 PGP--PPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPL---PPPPSERPPPPVR 370

Query: 129 TSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERG---PRTHTPAPL 179
             P         P + +           RALP  P L S  G   PR+    PL
Sbjct: 371 DPPGRSGPLPPPPPVSRNGSTS------RALPATPQLPSRSGVDSPRSGPRPPL 418



 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 54/173 (31%), Positives = 69/173 (39%), Gaps = 35/173 (20%)

Query: 13  PPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPD 72
           PP + +PP  +   P  +   PPPPPPP+   P PPPLPP               +  P 
Sbjct: 286 PPQNNKPPVPSTPRPSASSQAPPPPPPPS--RPGPPPLPPSSS----------GNDETPR 333

Query: 73  LPPRRRSSSRSL----ARGRITQCQVAASPLVPPPA---PPHCPRPLLCFLPAAGPAGLP 125
           LP R  S S S     + GR       + PL PPP+   PP    P     P   P   P
Sbjct: 334 LPQRNLSLSSSTPPLPSPGR-------SGPLPPPPSERPPPPVRDPPGRSGPLPPP---P 383

Query: 126 PLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAP 178
           P+  +  +       P+L   SG        R+ PR PPL  +R P    P P
Sbjct: 384 PVSRNGSTSRALPATPQLPSRSG----VDSPRSGPR-PPLPPDR-PSAGAPPP 430



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 38/122 (31%), Positives = 45/122 (36%), Gaps = 22/122 (18%)

Query: 5   GGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLL 64
           G  G   G     Q P S+ + P +  PP PP P       PPPP PP G R       +
Sbjct: 224 GNRGTALGGGSIRQSPLSSSS-PFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAV 282

Query: 65  LPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGL 124
            P  P  + PP   +   S           A+S   PPP PP  P          GP  L
Sbjct: 283 PPPPPQNNKPPVPSTPRPS-----------ASSQAPPPPPPPSRP----------GPPPL 321

Query: 125 PP 126
           PP
Sbjct: 322 PP 323



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 26/72 (36%), Positives = 29/72 (40%), Gaps = 22/72 (30%)

Query: 6   GEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPP-----------PPTPRPP--------- 45
           G  G   PP S +PP      PG + P PPPPP           P TP+ P         
Sbjct: 352 GRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPR 411

Query: 46  --PPPPLPPPGP 55
             P PPLPP  P
Sbjct: 412 SGPRPPLPPDRP 423



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 38/132 (28%), Positives = 52/132 (39%), Gaps = 23/132 (17%)

Query: 8   GGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPT 67
           G +  P +  +  S + + P    P    P PP P   PPPP+  P  R          +
Sbjct: 327 GNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGR----------S 376

Query: 68  EPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPR-----PLLCFLPAAGPA 122
            P P  PP  R+ S S A        + A+P +P  +    PR     PL    P+AG  
Sbjct: 377 GPLPPPPPVSRNGSTSRA--------LPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAP 428

Query: 123 GLPPLRTSPCSG 134
             PP  TS  +G
Sbjct: 429 PPPPPSTSIRNG 440



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 46/170 (27%), Positives = 57/170 (33%), Gaps = 32/170 (18%)

Query: 13  PPMSAQPPSSADTVPGTTYPPPP-------PPPPPTPRPPPPPPLPPPGPRLLRAC---- 61
           P + ++P S    VP T  P          PP P  PR P P P PPP P          
Sbjct: 174 PDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGG 233

Query: 62  ----SLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLP 117
               S L  + P  + PP   + SR+L                PPP PP   RP +    
Sbjct: 234 SIRQSPLSSSSPFSNRPPLPPTPSRAL------------DDKPPPPPPPVGNRPSIHREA 281

Query: 118 AAGPAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLAS 167
              P   PP    P   V    RP    ++        R   P  PP +S
Sbjct: 282 VPPP---PPQNNKP--PVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSS 326



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 47/180 (26%), Positives = 59/180 (32%), Gaps = 41/180 (22%)

Query: 5   GGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPP-----PPLPPPGPRLLR 59
           G   G   P  +  PP   D        PPP P  P P    P     PP+ P GPR   
Sbjct: 156 GHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPV-PGGPR--- 211

Query: 60  ACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQV-AASPLVPPPAPPHCPRPLLCFLPA 118
                    P P  PP   +   +L  G I Q  + ++SP    P  P  P   L   P 
Sbjct: 212 ------QPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP 265

Query: 119 AGPAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTPAP 178
             P   PP+   P                     +  R A+P  PP  + + P   TP P
Sbjct: 266 PPP---PPVGNRP---------------------SIHREAVPPPPP-QNNKPPVPSTPRP 300



 Score = 33.9 bits (76), Expect = 0.15
 Identities = 39/134 (29%), Positives = 50/134 (37%), Gaps = 6/134 (4%)

Query: 48  PPLPPPGPRLLRACSLLLPTEPA--PDLPPRRRSSSRSLARGRI--TQCQVAASPLVPPP 103
           PPL PPG R   A     P+ P   P   P  RS      R R+   +  V + P   PP
Sbjct: 126 PPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPP 185

Query: 104 APPHCPRPLLCFLPAAGPAGLPPLRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHP 163
             P  PRP+       G   +P     P  G T    P   + +  G  + R+  L    
Sbjct: 186 PVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPG-NRGTALGGGSIRQSPLSSSS 244

Query: 164 PLASERGPRTHTPA 177
           P  S R P   TP+
Sbjct: 245 PF-SNRPPLPPTPS 257


>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
          Length = 538

 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 75/261 (28%), Positives = 87/261 (33%), Gaps = 57/261 (21%)

Query: 11  AGPPMSAQPPSSADTVPGTTYPPPPPPPPPTPRP-------------------PPPPPLP 51
           A PP   + P  A        PPP P PPP P P                   PP P   
Sbjct: 106 ATPPAPPRAPRGAPAAAAAAAPPPTPAPPPPPAPVAAAAPARAPRAAAAAATAPPSPGPA 165

Query: 52  PPGPRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAA--SPLVPPPAPPHCP 109
            PGPR  RA  L  P  PAP  PP   + +      R     VAA   PL PPP PP  P
Sbjct: 166 QPGPRAQRAAPLAAP-PPAPAAPP---AVAPPAGPRRAPPPAVAAREPPLPPPPQPPAPP 221

Query: 110 RPLLCFLP---------------AAGPAGLPPLRTSPCSGVTFAGRPRLGQESG---QGV 151
           +      P               AA P  L  +           GR   G+  G   +  
Sbjct: 222 QQQQPPPPQPQPPPEGGAVRAGGAARPVSLREVVRYLGGSGGAGGRLTRGRVQGLLEEEA 281

Query: 152 AARRRRALPRHPPLASERGPRTHTPAPLWQACLVGWVKPQCVHTERRGAVERGSGLAE-- 209
           AAR R    R   LA  RG R     P   A      +P      +RG  ER     E  
Sbjct: 282 AARGRLERTRLGALALPRGDRPGRAPPAASA------RPS---RSKRGGEERVLEKEEEE 332

Query: 210 ---EDADQAPATQGNSELPRA 227
              ED D+       SE+P +
Sbjct: 333 DDDEDEDEEDDVSEGSEVPES 353



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 52/182 (28%), Positives = 65/182 (35%), Gaps = 27/182 (14%)

Query: 14  PMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDL 73
           P  A PP+ A   P    PP PP PP   +PPPP P PPP    +RA     P      +
Sbjct: 196 PRRAPPPAVAAREPPLPPPPQPPAPPQQQQPPPPQPQPPPEGGAVRAGGAARPVSLREVV 255

Query: 74  PPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSPCS 133
              R       A GR+T+ +V         A     R  L  L  A P G  P R  P +
Sbjct: 256 ---RYLGGSGGAGGRLTRGRVQGLLEEEAAARGRLERTRLGAL--ALPRGDRPGRAPPAA 310

Query: 134 GVTFAGRPRLGQE----------------------SGQGVAARRRRALPRHPPLASERGP 171
               +   R G+E                       G  V    R A  +H  L  ERGP
Sbjct: 311 SARPSRSKRGGEERVLEKEEEEDDDEDEDEEDDVSEGSEVPESDRPAGAQHHQLNGERGP 370

Query: 172 RT 173
           ++
Sbjct: 371 QS 372



 Score = 31.2 bits (69), Expect = 0.96
 Identities = 28/92 (30%), Positives = 35/92 (38%), Gaps = 12/92 (13%)

Query: 88  RITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSPCSGVTFAGRPRLGQES 147
           R+   +  A+P  PP AP   P       P   PA  PP   +P +    A  PR     
Sbjct: 98  RVQPPRRGATPPAPPRAPRGAPAAAAAAAPPPTPA--PPPPPAPVAAAAPARAPR----- 150

Query: 148 GQGVAARRRRALPRHPPLASERGPRTHTPAPL 179
               AA    A P   P  ++ GPR    APL
Sbjct: 151 ---AAAAAATAPPSPGP--AQPGPRAQRAAPL 177


>gi|157168329 formin 1 [Homo sapiens]
          Length = 1196

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 37/98 (37%), Positives = 39/98 (39%), Gaps = 49/98 (50%)

Query: 13  PPMSAQPPSSADTVPGTTYPPPPPPPPPTPRP----PPPPPLPPPGPRLLRACSLLLPTE 68
           PP+SA PP           PPPPPPPPP P P    PPPPP PPP           LP  
Sbjct: 672 PPVSAGPP----------LPPPPPPPPPLPPPSSAGPPPPPPPPP-----------LPNS 710

Query: 69  PAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPP 106
           PAP                         +P  PPPAPP
Sbjct: 711 PAP------------------------PNPGGPPPAPP 724



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 30/77 (38%), Positives = 35/77 (45%), Gaps = 17/77 (22%)

Query: 11  AGPPMSAQPPSSADTVPGTTYPPPPPPPPPT--------------PRPPPPPPLPPPGPR 56
           AGPP+   PP      P ++  PPPPPPPP               P PPPP   PPP P 
Sbjct: 676 AGPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPPPAPPPPGLAPPPPPG 735

Query: 57  L---LRACSLLLPTEPA 70
           L   L + S   P +PA
Sbjct: 736 LFFGLGSSSSQCPRKPA 752



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 48/152 (31%), Positives = 51/152 (33%), Gaps = 52/152 (34%)

Query: 9   GEAGPPMSAQPPSSADTVPGTTYPPPPPPPP------PTPRPPPP---PPLPPPGPRLLR 59
           G A     A PP      P  + PPPPP P       P P  PP    PPLPPP P    
Sbjct: 636 GMASNQQKALPP------PPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPP---- 685

Query: 60  ACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAA 119
                    P P LPP                   +A P  PPP PP  P       P  
Sbjct: 686 ---------PPPPLPP-----------------PSSAGP-PPPPPPPPLPNSPAPPNPGG 718

Query: 120 GPAGLPP--LRTSPCSGVTFAGRPRLGQESGQ 149
            P   PP  L   P  G+ F     LG  S Q
Sbjct: 719 PPPAPPPPGLAPPPPPGLFFG----LGSSSSQ 746


>gi|146134388 YLP motif containing 1 [Homo sapiens]
          Length = 2146

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 41/131 (31%), Positives = 51/131 (38%), Gaps = 16/131 (12%)

Query: 13   PPMSAQPPSSADTVPGTTYPPPPPP----------PPPTPRPPPPPPLPPPGPRLLRACS 62
            PP S +PP      PG+   P  PP          P P P PPPPPPLPPP P +    S
Sbjct: 1508 PPGSYRPPPPMGKPPGSIVRPSAPPARSSVPVTRPPVPIPPPPPPPPLPPPPPVIKPQTS 1567

Query: 63   LLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVP--PPAPPHCPRPLLCFLPAAG 120
             +       D       ++         + + AA P  P  PP P H   P     P   
Sbjct: 1568 AVEQERWDEDSFYGLWDTNDEQGLNSEFKSETAAIPSAPVLPPPPVHSSIP----PPGPV 1623

Query: 121  PAGLPPLRTSP 131
            P G+PP+   P
Sbjct: 1624 PMGMPPMSKPP 1634



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 58/177 (32%), Positives = 71/177 (40%), Gaps = 16/177 (9%)

Query: 14  PMSAQPPSSADTVPGTTYPPPPPPPP-PTPRPPP--PPPLPPPGPRLLRACSLLLPTEPA 70
           P    PP+   TVP    PPP  PP  PT  PPP  PP L   GP  +     L    P 
Sbjct: 543 PPPVMPPALPATVPPPGMPPPVMPPSLPTSVPPPGMPPSLSSAGPPPVLPPPSLSSAGPP 602

Query: 71  PDLPPRRRSSSRSLARGRITQCQVAASPL-VPPPAPPHCPRPLLCFLPAAGPAGLPPLRT 129
           P LPP   SS+       +     A  P  +PPP  P    P L   P      +PP  +
Sbjct: 603 PVLPPPSLSSTAPPPVMPLPPLSSATPPPGIPPPGVPQGIPPQLTAAP------VPPASS 656

Query: 130 SPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGP--RTHTPAPLWQACL 184
           S  S V    RP L       V+         HPPL S  GP  + ++ APL ++ L
Sbjct: 657 SQSSQVPEKPRPAL---LPTPVSFGSAPPTTYHPPLQS-AGPSEQVNSKAPLSKSAL 709



 Score = 54.7 bits (130), Expect = 8e-08
 Identities = 59/191 (30%), Positives = 76/191 (39%), Gaps = 35/191 (18%)

Query: 11  AGPPMSAQPPSSADTVPGTTYPPPP----PPPPPTPRPP-----PPPPLPPPGPRLLRAC 61
           AGPP    PPS +   P    PPP      PPP  P PP     PPP +PPPG       
Sbjct: 585 AGPPPVLPPPSLSSAGPPPVLPPPSLSSTAPPPVMPLPPLSSATPPPGIPPPG-----VP 639

Query: 62  SLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGP 121
             + P   A  +PP   SSS+S       +  +  +P+    APP    P    L +AGP
Sbjct: 640 QGIPPQLTAAPVPP--ASSSQSSQVPEKPRPALLPTPVSFGSAPPTTYHPP---LQSAGP 694

Query: 122 A----GLPPLRTSPCSGVTFAGRPRLGQES---GQGVAARRRRAL---------PRHPPL 165
           +       PL  S     +F+    LG+ S    Q + A +   +         PR   L
Sbjct: 695 SEQVNSKAPLSKSALPYSSFSSDQGLGESSAAPSQPITAVKDMPVRSGGLLPDPPRSSYL 754

Query: 166 ASERGPRTHTP 176
            S RGPR   P
Sbjct: 755 ESPRGPRFDGP 765



 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 56/186 (30%), Positives = 71/186 (38%), Gaps = 25/186 (13%)

Query: 15  MSAQPPSSADTVPGTTYPPPPPPPPPTPRPP--PPPPLPPPGPRLLRACSL-------LL 65
           MS  PP     VP +  PPP P  PP   PP  PPP +PP  P  +    +        L
Sbjct: 514 MSMPPPF----VPYSQMPPPLPTMPPPVLPPSLPPPVMPPALPATVPPPGMPPPVMPPSL 569

Query: 66  PTE-PAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPA------PPHCPRPLLCFLPA 118
           PT  P P +PP   S+         +       P++PPP+      PP  P P L    A
Sbjct: 570 PTSVPPPGMPPSLSSAGPPPVLPPPSLSSAGPPPVLPPPSLSSTAPPPVMPLPPLS--SA 627

Query: 119 AGPAGLPP--LRTSPCSGVTFAGRPRLGQESGQGVAARRRRALPRHPPLASERGPRTHTP 176
             P G+PP  +       +T A  P         V  + R AL   P       P T+ P
Sbjct: 628 TPPPGIPPPGVPQGIPPQLTAAPVPPASSSQSSQVPEKPRPALLPTPVSFGSAPPTTYHP 687

Query: 177 APLWQA 182
            PL  A
Sbjct: 688 -PLQSA 692



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 58/231 (25%), Positives = 81/231 (35%), Gaps = 30/231 (12%)

Query: 27  PGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPDLPPRRRSSSRSLAR 86
           P   Y   PPP P  P P  PP LPPP        ++  P  P P +PP   +S      
Sbjct: 519 PFVPYSQMPPPLPTMPPPVLPPSLPPPVMPPALPATVPPPGMPPPVMPPSLPTSVPPPGM 578

Query: 87  GRITQCQVAASPLVPPPA------PPHCPRPLLCFLPAAGPAGLPPLRT-SPCSGVTFAG 139
              +       P++PPP+      PP  P P L          LPPL + +P  G+   G
Sbjct: 579 PP-SLSSAGPPPVLPPPSLSSAGPPPVLPPPSLSSTAPPPVMPLPPLSSATPPPGIPPPG 637

Query: 140 RPRLGQESGQGVAARRRRA-LPRHPPLASERGPRTHTPAPLWQACLVGWVKPQCVHTERR 198
            P       QG+  +   A +P      S + P    PA L      G   P   H   +
Sbjct: 638 VP-------QGIPPQLTAAPVPPASSSQSSQVPEKPRPALLPTPVSFGSAPPTTYHPPLQ 690

Query: 199 GAVERGSGLAEEDADQAPATQGNSELPRAALRVSEENRGDGRNMGEGGLFP 249
            A               P+ Q NS+ P +   +   +    + +GE    P
Sbjct: 691 SA--------------GPSEQVNSKAPLSKSALPYSSFSSDQGLGESSAAP 727



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 36/114 (31%), Positives = 43/114 (37%), Gaps = 19/114 (16%)

Query: 32  PPPPPPPPPTP-------RPPPPPPLPPPGPRL-------LRACSLLLPTEPAPDLPPRR 77
           PPP PPPP  P       +PPPPP  PPPGP L        +   L    +  P L P  
Sbjct: 83  PPPLPPPPVMPGGGYGDWQPPPPPMPPPPGPALSYQKQQQYKHQMLHHQRDGPPGLVPME 142

Query: 78  RSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSP 131
             S               +   +PPP PP    P     P +    LPP + SP
Sbjct: 143 LESPPESPPVPPGSYMPPSQSYMPPPQPPPSYYP-----PTSSQPYLPPAQPSP 191



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 37/116 (31%), Positives = 47/116 (40%), Gaps = 11/116 (9%)

Query: 13  PPMSAQPPSSADTVPGTTYPPPPPPP----PPTPRPPPPPPLPPPGPRLLRACSLLLPTE 68
           PP S   P  +   P  +Y PPP PP    PPT   P  PP  P   +   + S L PT 
Sbjct: 146 PPESPPVPPGSYMPPSQSYMPPPQPPPSYYPPTSSQPYLPPAQPSPSQSPPSQSYLAPT- 204

Query: 69  PAPDLPPRRRSSSRSLARGRITQCQVAASPLVPP-PAPPHCPRPLLCFLPAAGPAG 123
                P    SSS S +    +Q  + +S   P  P+  H    LL   P + P G
Sbjct: 205 -----PSYSSSSSSSQSYLSHSQSYLPSSQASPSRPSQGHSKSQLLAPPPPSAPPG 255



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 31/99 (31%), Positives = 40/99 (40%), Gaps = 23/99 (23%)

Query: 13   PPMSAQPPSSADTVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPAPD 72
            P M+   P     +  T+  P   PPP + RPPPP   PP    ++R           P 
Sbjct: 1483 PQMADHLPPQESRLQNTSSRPGMYPPPGSYRPPPPMGKPPGS--IVR-----------PS 1529

Query: 73   LPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRP 111
             PP R  SS  + R  +        P+ PPP PP  P P
Sbjct: 1530 APPAR--SSVPVTRPPV--------PIPPPPPPPPLPPP 1558



 Score = 36.6 bits (83), Expect = 0.023
 Identities = 25/82 (30%), Positives = 35/82 (42%), Gaps = 6/82 (7%)

Query: 28  GTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLLLPTEPA-PDLPPRRRSSSRSLAR 86
           G+++ PPPP PPP   PP   P   PGP    + +   P+         +  +  + L +
Sbjct: 10  GSSHYPPPPVPPP---PPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQLQQLQQ 66

Query: 87  GRITQCQVAASP--LVPPPAPP 106
               Q Q    P  L PPP PP
Sbjct: 67  MHQKQMQCVLQPHHLPPPPLPP 88



 Score = 35.8 bits (81), Expect = 0.039
 Identities = 26/93 (27%), Positives = 33/93 (35%), Gaps = 22/93 (23%)

Query: 8   GGEAGPPMSAQPPSSAD---TVPGTTYPPPPPPPPPTPRPPPPPPLPPPGPRLLRACSLL 64
           G + GP ++   P       TVP T+  P  P     P PPP   +PPP           
Sbjct: 315 GHKKGPVVAKDTPEPVKEEVTVPATSQVPESPSSEEPPLPPPNEEVPPP----------- 363

Query: 65  LPTEPAPDLPPRRRSSSRSLARGRITQCQVAAS 97
                   LPP    S       R+ Q Q AA+
Sbjct: 364 --------LPPEEPQSEDPEEDARLKQLQAAAA 388



 Score = 31.6 bits (70), Expect = 0.73
 Identities = 14/27 (51%), Positives = 14/27 (51%), Gaps = 5/27 (18%)

Query: 32   PPPP-----PPPPPTPRPPPPPPLPPP 53
            PPPP     PPP P P   PP   PPP
Sbjct: 1609 PPPPVHSSIPPPGPVPMGMPPMSKPPP 1635



 Score = 31.2 bits (69), Expect = 0.96
 Identities = 15/45 (33%), Positives = 21/45 (46%), Gaps = 4/45 (8%)

Query: 15   MSAQPPSSADTVPGTTYPPPPPP----PPPTPRPPPPPPLPPPGP 55
            ++++  S    +P     PPPP     PPP P P   PP+  P P
Sbjct: 1591 LNSEFKSETAAIPSAPVLPPPPVHSSIPPPGPVPMGMPPMSKPPP 1635


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 42/128 (32%), Positives = 46/128 (35%), Gaps = 47/128 (36%)

Query: 4   AGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPP-----------PPPTPRPPPPPPLPP 52
           +  E G       A+ PS    V G   PPPPPP            PP P PPPPPPLP 
Sbjct: 285 SASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPS 344

Query: 53  PGPRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPL 112
            GP          P  P P LP +                     P  PPPAPP      
Sbjct: 345 TGPP---------PPPPPPPLPNQ------------------VPPPPPPPPAPP------ 371

Query: 113 LCFLPAAG 120
              LPA+G
Sbjct: 372 ---LPASG 376



 Score = 32.7 bits (73), Expect = 0.33
 Identities = 16/45 (35%), Positives = 20/45 (44%)

Query: 90  TQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSPCSG 134
           +Q  +   PL PPP PP  P P    +    P G PP    P +G
Sbjct: 302 SQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTG 346


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 42/128 (32%), Positives = 46/128 (35%), Gaps = 47/128 (36%)

Query: 4   AGGEGGEAGPPMSAQPPSSADTVPGTTYPPPPPP-----------PPPTPRPPPPPPLPP 52
           +  E G       A+ PS    V G   PPPPPP            PP P PPPPPPLP 
Sbjct: 285 SASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPS 344

Query: 53  PGPRLLRACSLLLPTEPAPDLPPRRRSSSRSLARGRITQCQVAASPLVPPPAPPHCPRPL 112
            GP          P  P P LP +                     P  PPPAPP      
Sbjct: 345 TGPP---------PPPPPPPLPNQ------------------VPPPPPPPPAPP------ 371

Query: 113 LCFLPAAG 120
              LPA+G
Sbjct: 372 ---LPASG 376



 Score = 32.7 bits (73), Expect = 0.33
 Identities = 16/45 (35%), Positives = 20/45 (44%)

Query: 90  TQCQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSPCSG 134
           +Q  +   PL PPP PP  P P    +    P G PP    P +G
Sbjct: 302 SQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTG 346


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.136    0.445 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,920,729
Number of Sequences: 37866
Number of extensions: 1654483
Number of successful extensions: 69949
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1633
Number of HSP's successfully gapped in prelim test: 1352
Number of HSP's that attempted gapping in prelim test: 14034
Number of HSP's gapped (non-prelim): 20533
length of query: 262
length of database: 18,247,518
effective HSP length: 100
effective length of query: 162
effective length of database: 14,460,918
effective search space: 2342668716
effective search space used: 2342668716
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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