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Search of human proteins with 194294525
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
(1249 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 2491 0.0
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 2463 0.0
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 2395 0.0
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 1216 0.0
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 1155 0.0
gi|10864047 epidermal growth factor receptor pathway substrate 1... 151 3e-36
gi|4503593 epidermal growth factor receptor pathway substrate 15... 125 3e-28
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 125 3e-28
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 125 3e-28
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 125 3e-28
gi|148746195 trichohyalin [Homo sapiens] 121 5e-27
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 105 3e-22
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 103 1e-21
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 101 4e-21
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 98 6e-20
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 97 1e-19
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 93 2e-18
gi|125625326 RALBP1 associated Eps domain containing 2 isoform 1... 92 2e-18
gi|125625322 RALBP1 associated Eps domain containing 2 isoform 2... 91 7e-18
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 91 9e-18
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 90 1e-17
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 89 3e-17
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 89 3e-17
gi|71061468 centromere protein E [Homo sapiens] 88 4e-17
gi|11321634 CD2-associated protein [Homo sapiens] 87 1e-16
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 85 4e-16
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 85 5e-16
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 85 5e-16
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 85 5e-16
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 85 5e-16
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 2491 bits (6455), Expect = 0.0
Identities = 1249/1249 (100%), Positives = 1249/1249 (100%)
Query: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA
Sbjct: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
Query: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG
Sbjct: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
Query: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI
Sbjct: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
Query: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV
Sbjct: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
Query: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE
Sbjct: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
Query: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP
Sbjct: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
Query: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL
Sbjct: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
Query: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE
Sbjct: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
Query: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL
Sbjct: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
Query: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD
Sbjct: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
Query: 601 ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA 660
ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA
Sbjct: 601 ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA 660
Query: 661 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 720
LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ
Sbjct: 661 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 720
Query: 721 EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 780
EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS
Sbjct: 721 EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 780
Query: 781 GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 840
GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA
Sbjct: 781 GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 840
Query: 841 TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 900
TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN
Sbjct: 841 TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 900
Query: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 960
LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK
Sbjct: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 960
Query: 961 REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 1020
REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG
Sbjct: 961 REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 1020
Query: 1021 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1080
SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI
Sbjct: 1021 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1080
Query: 1081 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1140
LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA
Sbjct: 1081 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1140
Query: 1141 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1200
NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL
Sbjct: 1141 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1200
Query: 1201 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVRRLLLASSRGICCLS 1249
DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVRRLLLASSRGICCLS
Sbjct: 1201 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVRRLLLASSRGICCLS 1249
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 2463 bits (6384), Expect = 0.0
Identities = 1236/1242 (99%), Positives = 1238/1242 (99%)
Query: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA
Sbjct: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
Query: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG
Sbjct: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
Query: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI
Sbjct: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
Query: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV
Sbjct: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
Query: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE
Sbjct: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
Query: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP
Sbjct: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
Query: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL
Sbjct: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
Query: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE
Sbjct: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
Query: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL
Sbjct: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
Query: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD
Sbjct: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
Query: 601 ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA 660
ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA
Sbjct: 601 ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA 660
Query: 661 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 720
LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ
Sbjct: 661 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 720
Query: 721 EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 780
EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS
Sbjct: 721 EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 780
Query: 781 GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 840
GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA
Sbjct: 781 GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 840
Query: 841 TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 900
TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN
Sbjct: 841 TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 900
Query: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 960
LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK
Sbjct: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 960
Query: 961 REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 1020
REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG
Sbjct: 961 REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 1020
Query: 1021 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1080
SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI
Sbjct: 1021 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1080
Query: 1081 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1140
LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA
Sbjct: 1081 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1140
Query: 1141 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1200
NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL
Sbjct: 1141 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1200
Query: 1201 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVRRLLLASS 1242
DTMQPIERKRQGYIHELIQTEERYMADLQLVVEV + +A S
Sbjct: 1201 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAES 1242
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 2395 bits (6206), Expect = 0.0
Identities = 1209/1242 (97%), Positives = 1211/1242 (97%), Gaps = 27/1242 (2%)
Query: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA
Sbjct: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
Query: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG
Sbjct: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
Query: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI
Sbjct: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
Query: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV
Sbjct: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
Query: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE
Sbjct: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
Query: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP
Sbjct: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
Query: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL
Sbjct: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
Query: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE
Sbjct: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
Query: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL
Sbjct: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
Query: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD
Sbjct: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
Query: 601 ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA 660
ALEKETASKLSEMDSFNNQ LKELRETYNTQQLA
Sbjct: 601 ALEKETASKLSEMDSFNNQ---------------------------LKELRETYNTQQLA 633
Query: 661 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 720
LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ
Sbjct: 634 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 693
Query: 721 EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 780
EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS
Sbjct: 694 EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 753
Query: 781 GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 840
GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA
Sbjct: 754 GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 813
Query: 841 TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 900
TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN
Sbjct: 814 TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 873
Query: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 960
LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK
Sbjct: 874 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 933
Query: 961 REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 1020
REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG
Sbjct: 934 REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 993
Query: 1021 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1080
SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI
Sbjct: 994 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1053
Query: 1081 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1140
LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA
Sbjct: 1054 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1113
Query: 1141 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1200
NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL
Sbjct: 1114 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1173
Query: 1201 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVRRLLLASS 1242
DTMQPIERKRQGYIHELIQTEERYMADLQLVVEV + +A S
Sbjct: 1174 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAES 1215
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 1216 bits (3147), Expect = 0.0
Identities = 691/1324 (52%), Positives = 885/1324 (66%), Gaps = 153/1324 (11%)
Query: 2 MAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAE 61
MAQFPT G ++WAIT EER KHD+QF +LKP G+ITGDQARNFF QSGLP PVLA+
Sbjct: 1 MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ 60
Query: 62 IWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGS 121
IWAL+D+N DG+MDQ EFSIAMKLIKLKLQG QLP LPP+MKQ P+ A FGMG
Sbjct: 61 IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPA-FGMGG 119
Query: 122 MPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLP---NGTASLIQPL 178
+ ++ P+T+++ G+ +P + M LV SV T+++P NG +IQPL
Sbjct: 120 IASMP---------PLTAVAPVPMGS-IPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPL 169
Query: 179 P-IPYSSSTLPHGSSYSLMMGGFG-GASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTS 236
P + ++TLP SS+S G +QKAQS D+ S +
Sbjct: 170 PAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSF-DVASVPPVA--------------- 213
Query: 237 EWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQ 296
EWAVPQ +RLKYRQ FN+ DK+MSG+L+G QAR L+QS+L Q QLA+IW L+D+D DG+
Sbjct: 214 EWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGK 273
Query: 297 LKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR---GGKQIDSINGT-----LPSYQ 348
L AEEFILAMHL D+A +GQPLP LPPE +PPSFR G I I+ T LP
Sbjct: 274 LTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEP 333
Query: 349 KMQEEEPQ--KKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
+++E+ Q KKLPVTFEDK++ N+ERGN+ELEKRRQAL+EQQ++E ER AQ E+ E ER
Sbjct: 334 VLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQER 393
Query: 407 KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIR 466
K+RE QEQE K+QLELEK+LEKQRELERQREEERRK+IERREAAK+ELERQR+LEWER R
Sbjct: 394 KERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNR 453
Query: 467 RQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVL 526
RQELLNQ+N+EQE+IV L +KKK L ELEALN K Q+ G+LQD+R + TQ+ E+E
Sbjct: 454 RQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIEST 513
Query: 527 DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNT-PDSGVSLLHKKS 585
+K +L I EI LQQ+LQE Q L L+PEKQ+LN+++K +Q ++ DS V+L K++
Sbjct: 514 NKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTL--KRA 571
Query: 586 LEKEELC-QRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLF 644
LE +EL Q L++QLD +EKET SKL E+D FNNQ
Sbjct: 572 LEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQ------------------------- 606
Query: 645 LLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLW 704
LKELRE +N QQL ++ + +R K KE ERK +EL +K ++EA R+A Q ++ W
Sbjct: 607 --LKELREIHNKQQLQKQKSMEAERLKQKEQERKIIEL---EKQKEEAQRRA-QERDKQW 660
Query: 705 KENLRKEEE--------EKQKRLQEEKTQEKIQEEERKAE----------EKQRKDKDTL 746
E++++E+E E++K +EE ++K EE+ K E + Q K +
Sbjct: 661 LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAV 720
Query: 747 KA----EEKKRETASV-----LVNYRALYPFEARNHDEMSFNSGDIIQ-----VDEKTVG 792
+A EK T S +V YRALYPFE+R+HDE++ GDI+ VDE G
Sbjct: 721 QAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG 780
Query: 793 EPGWLYGSFQGNFGWFPCNYVEKMPSSE----------NEKAVSPKKALLPPTVSLSATS 842
EPGWL G +G GWFP NY EK+P +E + A +PK AL L+ TS
Sbjct: 781 EPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTS 840
Query: 843 -------------TSSEPLSSNQPASVTDYQN-VSFSNLTVNTSWQ--KKSAFTRTVSPG 886
+S+ P S+N+ ++ + +LTV ++ Q ++SAFT + G
Sbjct: 841 SEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATG 900
Query: 887 -SVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGW 945
S SP+ GQG+ VE L+AQAL W AKKDNHLNF+K+D+ITVLEQQ+ WWFGEV G +GW
Sbjct: 901 SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGW 960
Query: 946 FPKSYVKIIPGSEVK--------REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEP 997
FPKSYVK+I G K E P +L + P + GEE+IA+Y Y S E
Sbjct: 961 FPKSYVKLISGPIRKSTSMDSGSSESPASLKRVAS--PAAKPVVSGEEFIAMYTYESSEQ 1018
Query: 998 GDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEI 1057
GDLTF +G+ ILVT+KDG+WWTG++GD++G+FPSNYV+ KD E G+A K+G+ KKPEI
Sbjct: 1019 GDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEI 1078
Query: 1058 AQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGP 1117
AQV ++Y A+G EQL+LAPGQLILI KKN GWW+GELQARGKKRQ GWFPA++VKLL P
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
Query: 1118 SSERATPAFHP-------VCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEIN 1170
+ + TP P VCQVI MYDY A N+DEL+F+KGQ+INV+NK+DPDWW+GE+N
Sbjct: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 1171 GVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQL 1230
G GLFPSNYVK+TTD DPSQQWC+DL LD + P ERKRQGYIHELI TEE Y+ DLQL
Sbjct: 1199 GQVGLFPSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQL 1258
Query: 1231 VVEV 1234
V E+
Sbjct: 1259 VTEI 1262
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 1155 bits (2988), Expect = 0.0
Identities = 662/1282 (51%), Positives = 852/1282 (66%), Gaps = 153/1282 (11%)
Query: 2 MAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAE 61
MAQFPT G ++WAIT EER KHD+QF +LKP G+ITGDQARNFF QSGLP PVLA+
Sbjct: 1 MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ 60
Query: 62 IWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGS 121
IWAL+D+N DG+MDQ EFSIAMKLIKLKLQG QLP LPP+MKQ P+ A FGMG
Sbjct: 61 IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPA-FGMGG 119
Query: 122 MPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLP---NGTASLIQPL 178
+ ++ P+T+++ G+ +P + M LV SV T+++P NG +IQPL
Sbjct: 120 IASMP---------PLTAVAPVPMGS-IPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPL 169
Query: 179 P-IPYSSSTLPHGSSYSLMMGGFG-GASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTS 236
P + ++TLP SS+S G +QKAQS D+ S +
Sbjct: 170 PAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSF-DVASVPPVA--------------- 213
Query: 237 EWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQ 296
EWAVPQ +RLKYRQ FN+ DK+MSG+L+G QAR L+QS+L Q QLA+IW L+D+D DG+
Sbjct: 214 EWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGK 273
Query: 297 LKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR---GGKQIDSINGT-----LPSYQ 348
L AEEFILAMHL D+A +GQPLP LPPE +PPSFR G I I+ T LP
Sbjct: 274 LTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEP 333
Query: 349 KMQEEEPQ--KKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
+++E+ Q KKLPVTFEDK++ N+ERGN+ELEKRRQAL+EQQ++E ER AQ E+ E ER
Sbjct: 334 VLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQER 393
Query: 407 KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIR 466
K+RE QEQE K+QLELEK+LEKQRELERQREEERRK+IERREAAK+ELERQR+LEWER R
Sbjct: 394 KERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNR 453
Query: 467 RQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVL 526
RQELLNQ+N+EQE+IV L +KKK L ELEALN K Q+ G+LQD+R + TQ+ E+E
Sbjct: 454 RQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIEST 513
Query: 527 DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNT-PDSGVSLLHKKS 585
+K +L I EI LQQ+LQE Q L L+PEKQ+LN+++K +Q ++ DS V+L K++
Sbjct: 514 NKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTL--KRA 571
Query: 586 LEKEELC-QRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLF 644
LE +EL Q L++QLD +EKET SKL E+D FNNQ
Sbjct: 572 LEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQ------------------------- 606
Query: 645 LLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLW 704
LKELRE +N QQL ++ + +R K KE ERK +EL +K ++EA R+A Q ++ W
Sbjct: 607 --LKELREIHNKQQLQKQKSMEAERLKQKEQERKIIEL---EKQKEEAQRRA-QERDKQW 660
Query: 705 KENLRKEEE--------EKQKRLQEEKTQEKIQEEERKAE----------EKQRKDKDTL 746
E++++E+E E++K +EE ++K EE+ K E + Q K +
Sbjct: 661 LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAV 720
Query: 747 KA----EEKKRETASV-----LVNYRALYPFEARNHDEMSFNSGDIIQ-----VDEKTVG 792
+A EK T S +V YRALYPFE+R+HDE++ GDI+ VDE G
Sbjct: 721 QAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG 780
Query: 793 EPGWLYGSFQGNFGWFPCNYVEKMPSSE----------NEKAVSPKKALLPPTVSLSATS 842
EPGWL G +G GWFP NY EK+P +E + A +PK AL L+ TS
Sbjct: 781 EPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTS 840
Query: 843 -------------TSSEPLSSNQPASVTDYQN-VSFSNLTVNTSWQ--KKSAFTRTVSPG 886
+S+ P S+N+ ++ + +LTV ++ Q ++SAFT + G
Sbjct: 841 SEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATG 900
Query: 887 -SVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGW 945
S SP+ GQG+ VE L+AQAL W AKKDNHLNF+K+D+ITVLEQQ+ WWFGEV G +GW
Sbjct: 901 SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGW 960
Query: 946 FPKSYVKIIPGSEVK--------REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEP 997
FPKSYVK+I G K E P +L + P + GEE+IA+Y Y S E
Sbjct: 961 FPKSYVKLISGPIRKSTSMDSGSSESPASLKRVAS--PAAKPVVSGEEFIAMYTYESSEQ 1018
Query: 998 GDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEI 1057
GDLTF +G+ ILVT+KDG+WWTG++GD++G+FPSNYV+ KD E G+A K+G+ KKPEI
Sbjct: 1019 GDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEI 1078
Query: 1058 AQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGP 1117
AQV ++Y A+G EQL+LAPGQLILI KKN GWW+GELQARGKKRQ GWFPA++VKLL P
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
Query: 1118 SSERATPAFHP-------VCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEIN 1170
+ + TP P VCQVI MYDY A N+DEL+F+KGQ+INV+NK+DPDWW+GE+N
Sbjct: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 1171 GVTGLFPSNYVKMTTDSDPSQQ 1192
G GLFPSNYVK+TTD DPSQQ
Sbjct: 1199 GQVGLFPSNYVKLTTDMDPSQQ 1220
>gi|10864047 epidermal growth factor receptor pathway substrate
15-like 1 [Homo sapiens]
Length = 864
Score = 151 bits (382), Expect = 3e-36
Identities = 143/547 (26%), Positives = 246/547 (44%), Gaps = 110/547 (20%)
Query: 16 WAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMD 75
WA+ EE+ K D F++L P G ++GD+ + + S LP VL +W LSD++KDG +D
Sbjct: 121 WAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD 180
Query: 76 QQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAA 135
+ EF++AM L+ L+ +P+P A
Sbjct: 181 RDEFAVAMHLVYRALE------------------------------------KEPVPSA- 203
Query: 136 PITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSS--STLPHGSSY 193
LPP ++P PS ++ G ++ P P S ST HGS
Sbjct: 204 -------------LPPSLIP----PSKRKKTVFPGAVPVLPASPPPKDSLRSTPSHGSVS 246
Query: 194 SLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFN 253
SL S+ S S SL P T W VP ++++ + F
Sbjct: 247 SL-------------------NSTGSLSPKHSLKQTQP---TVNWVVPVADKMRFDEIFL 284
Query: 254 TLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH-LTDMA 312
D + GY+SG + + + S L+Q LA IW LAD G+L ++F LAM+ +
Sbjct: 285 KTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKV 344
Query: 313 KAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYE 372
G P L P++VPPS RG DS +G+L S E K+L ++ + E
Sbjct: 345 SKGIDPPQVLSPDMVPPSERGTPGPDS-SGSLGS----GEFTGVKELDDISQEIAQLQRE 399
Query: 373 RGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQREL 432
+ ++E + R + E+ R+ + Q+ + + +R+ LQE E +KQ + + RL+ E+
Sbjct: 400 KYSLEQDIREK---EEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ-DAQDRLD---EM 452
Query: 433 ERQREEERRKDIERREAAKQELERQRRLEWE-RIRRQELLNQK---NREQEEIVRLNSKK 488
++Q+ + R + R+ + E + L+ + + + +L +Q+ NR + E+ RL ++
Sbjct: 453 DQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEE 512
Query: 489 KNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQE----L 544
L ++A GR+Q + K + T+ E+ Q ++ ++ + +QE L
Sbjct: 513 TQLEQSIQA---------GRVQLETIIKSLKSTQDEI--NQARSKLSQLHESRQEAHRSL 561
Query: 545 QEYQNKL 551
++Y L
Sbjct: 562 EQYDQVL 568
Score = 75.1 bits (183), Expect = 4e-13
Identities = 39/103 (37%), Positives = 58/103 (56%), Gaps = 1/103 (0%)
Query: 230 SPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLA 289
+P + + WAV + K+ F +L ++G LSG + + L+ S L L +W L+
Sbjct: 113 TPPSAEAHWAVRVEEKAKFDGIFESL-LPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLS 171
Query: 290 DVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR 332
D+D DG L +EF +AMHL A +P+P LPP L+PPS R
Sbjct: 172 DIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKR 214
Score = 47.8 bits (112), Expect = 7e-05
Identities = 49/209 (23%), Positives = 92/209 (44%), Gaps = 23/209 (11%)
Query: 442 KDIERREAAKQELERQRRLEWERIRR-----QELLNQKNREQEEIVRLNSKKKNLHLELE 496
++I + + K LE+ R + E IR+ QEL N +RE + L ++K++ L+
Sbjct: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLD 450
Query: 497 ALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVP 556
++ + ++ L DVR K Q + + L Q + ++K + +L +++L L
Sbjct: 451 EMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQ 510
Query: 557 EKQLLNER-----------IKNMQFS----NTPDSGVSLLHKKSLEKEELCQRLKEQLDA 601
E+ L + IK+++ + N S +S LH+ E ++ + LD
Sbjct: 511 EETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDG 570
Query: 602 LEKET---ASKLSEMDSFNNQLKCGNMDD 627
+ + LSE S + G MDD
Sbjct: 571 AHGASLTDLANLSEGVSLAERGSFGAMDD 599
Score = 45.1 bits (105), Expect = 4e-04
Identities = 27/85 (31%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 248 YRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH 307
Y + +D + +G + +A L +S LS L IW LAD +G G L + F +A+
Sbjct: 19 YESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALR 78
Query: 308 LTDMAKAGQPLPLT-LPPELVPPSF 331
L A++G + L+ L + PP F
Sbjct: 79 LVACAQSGHEVTLSNLNLSMPPPKF 103
Score = 39.3 bits (90), Expect = 0.024
Identities = 33/176 (18%), Positives = 86/176 (48%), Gaps = 4/176 (2%)
Query: 505 ISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNER 564
IS + ++ +K + + ++ ++ + E+++LQ +L + L L +KQ +R
Sbjct: 389 ISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDR 448
Query: 565 IKNM--QFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKC 622
+ M Q + D +S + +K ++ ++ LK Q+ + E + S+ +++ ++L
Sbjct: 449 LDEMDQQKAKLRDM-LSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNR 507
Query: 623 GNMDDSVL-QCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIER 677
+++ L Q + + L + LK ++ N + L QL++ +++ + +E+
Sbjct: 508 LQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQ 563
>gi|4503593 epidermal growth factor receptor pathway substrate 15
isoform A [Homo sapiens]
Length = 896
Score = 125 bits (314), Expect = 3e-28
Identities = 131/526 (24%), Positives = 224/526 (42%), Gaps = 52/526 (9%)
Query: 25 KHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMK 84
K+ RQ D + G + A F +SGLP +L +IW L+D + G +++QEF +A++
Sbjct: 21 KYYRQVDT--GNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Query: 85 LIKLKLQGQQLPVVLPPIMKQPPMF----SPLISARFGMGSMPNLSIPQPLPPAAPITSL 140
L+ G ++ + + PP F SPL+ + +P P+ I
Sbjct: 79 LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDS 138
Query: 141 SSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGF 200
S +G + + P + S LP + L + S + H G
Sbjct: 139 LSPVNG-----FLSGDKVKPVLLNSKLP------VDILGRVWELSDIDHD-------GML 180
Query: 201 GGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMS 260
A L+ + P + W V + KY + F DK M
Sbjct: 181 DRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMD 240
Query: 261 GYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMHLTD--MAKAGQPL 318
G++SG + R L++ L T LA IW+L D G+L ++F LA HL + K P
Sbjct: 241 GFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDP- 299
Query: 319 PLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMEL 378
P L PE++PPS R Q +I G+ P + + K+L + E+ N+E
Sbjct: 300 PHVLTPEMIPPSDRASLQ-KNIIGSSP----VADFSAIKELDTLNNEIVDLQREKNNVEQ 354
Query: 379 EKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREE 438
+ + + +Q+ + Q E + ++LQ Q+ + Q L++ E++ +LE Q +E
Sbjct: 355 DLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKE 414
Query: 439 ERRKDIERRE---AAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLEL 495
R+K E + + K EL Q +I E + + +EE+ RL + L +
Sbjct: 415 VRKKCAEEAQLISSLKAELTSQE----SQISTYE--EELAKAREELSRLQQETAELEESV 468
Query: 496 EALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQ 541
E SG+ Q L++ Q ++ E+ Q +++ME+K L+
Sbjct: 469 E---------SGKAQLEPLQQHLQDSQQEISSMQ--MKLMEMKDLE 503
Score = 93.6 bits (231), Expect = 1e-18
Identities = 112/481 (23%), Positives = 189/481 (39%), Gaps = 92/481 (19%)
Query: 220 TSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQ 279
TSS +SG S WAV + KY F++L ++G+LSG + + LL S L
Sbjct: 106 TSSPLLISGTS--AAELPWAVKPEDKAKYDAIFDSLSP-VNGFLSGDKVKPVLLNSKLPV 162
Query: 280 TQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDS 339
L +W L+D+D DG L +EF +AM L A +P+P++LPP LVP
Sbjct: 163 DILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVP----------- 211
Query: 340 INGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQ-REAERKAQ 398
P K+ KA Y+ ++ +K + + RE K
Sbjct: 212 ---------------PSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTG 256
Query: 399 KEK----EEWERKQRELQEQEWKKQLELEKRLEKQRELE-----RQREEERRKDIERREA 449
W + + K Q L L Q+ ++ E +R
Sbjct: 257 LPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASL 316
Query: 450 AKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRL 509
K + ++ I+ + LN EIV L +K N+ +L+ +Q + +
Sbjct: 317 QKNIIGSSPVADFSAIKELDTLNN------EIVDLQREKNNVEQDLKEKEDTIKQRTSEV 370
Query: 510 QDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQ 569
QD++ + Q + T L+ +LQ + Q+ Q L L +K L E++K ++
Sbjct: 371 QDLQDEVQRENTNLQ--------------KLQAQKQQVQELLDELDEQKAQLEEQLKEVR 416
Query: 570 FSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSV 629
KK E+ +L LK +L + E + ++ E+ +
Sbjct: 417 -------------KKCAEEAQLISSLKAELTSQESQISTYEEELAKAREE---------- 453
Query: 630 LQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLE 689
L+ L EL E+ + + LE L + +D +EI +++LM+ K LE
Sbjct: 454 ----------LSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLE 503
Query: 690 D 690
+
Sbjct: 504 N 504
Score = 85.9 bits (211), Expect = 2e-16
Identities = 35/91 (38%), Positives = 59/91 (64%)
Query: 16 WAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMD 75
WA+ E++ K+D FD+L P G+++GD+ + L S LP +L +W LSD++ DG +D
Sbjct: 122 WAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLD 181
Query: 76 QQEFSIAMKLIKLKLQGQQLPVVLPPIMKQP 106
+ EF++AM L+ L+ + +P+ LPP + P
Sbjct: 182 RDEFAVAMFLVYCALEKEPVPMSLPPALVPP 212
Score = 64.7 bits (156), Expect = 5e-10
Identities = 35/93 (37%), Positives = 54/93 (58%), Gaps = 2/93 (2%)
Query: 16 WAITSEERTKHDRQFDNL-KPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKM 74
W ++ E+ K+D F K G+++G + R FL++GLP+ +LA IW+L D GK+
Sbjct: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277
Query: 75 DQQEFSIAMKLIKLKL-QGQQLPVVLPPIMKQP 106
+ +F++A LI KL +G P VL P M P
Sbjct: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEMIPP 310
Score = 46.2 bits (108), Expect = 2e-04
Identities = 36/126 (28%), Positives = 55/126 (43%), Gaps = 12/126 (9%)
Query: 248 YRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH 307
Y + + +D +G + A L +S L L IW LAD DG G L +EF +A+
Sbjct: 19 YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Query: 308 LTDMAKAGQPLPL-TLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDK 366
L A+ G + L +L + PP F I+GT + +LP + +
Sbjct: 79 LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAA-----------ELPWAVKPE 127
Query: 367 RKANYE 372
KA Y+
Sbjct: 128 DKAKYD 133
Score = 34.3 bits (77), Expect = 0.76
Identities = 37/151 (24%), Positives = 67/151 (44%), Gaps = 22/151 (14%)
Query: 608 SKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKI 667
S + E+D+ NN++ + L NN+ LKE +T + ++ L
Sbjct: 330 SAIKELDTLNNEI-------------VDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDE 376
Query: 668 KRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQ------KRLQE 721
+ + +++ + + Q ++L DE + Q +E L KE +K EE Q L
Sbjct: 377 VQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQL-KEVRKKCAEEAQLISSLKAELTS 435
Query: 722 EKTQEKIQEEE--RKAEEKQRKDKDTLKAEE 750
+++Q EEE + EE R ++T + EE
Sbjct: 436 QESQISTYEEELAKAREELSRLQQETAELEE 466
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 125 bits (314), Expect = 3e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 890 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 947
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 427 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 486
Query: 948 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 1003
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 487 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 534
Query: 1004 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1045
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 535 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 594
Query: 1046 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1105
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 595 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 649
Query: 1106 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1164
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 650 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 708
Query: 1165 WQGEINGVTGLFPSNYVK 1182
GE+ G +G+FP NY++
Sbjct: 709 MSGELMGKSGIFPKNYIQ 726
Score = 92.8 bits (229), Expect = 2e-18
Identities = 96/399 (24%), Positives = 165/399 (41%), Gaps = 70/399 (17%)
Query: 816 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 875
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 297 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 352
Query: 876 KSAFTR--TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN 933
F V P P H + + + D++ +L+Q EN
Sbjct: 353 SQVFKNQDPVLPPRPKPGH---------------------PLYSKYMRGDVLVMLKQTEN 391
Query: 934 WWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYP 991
+ G G S +KII P E R P A + A ++V L+
Sbjct: 392 NYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV-----VLHD 446
Query: 992 YSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGSASKSG 1049
+ + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+ +
Sbjct: 447 FPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKREC 506
Query: 1050 ASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1107
S+ K Y+ ++LS + G++I++ + W +GE++ R G F
Sbjct: 507 VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR-----TGIF 561
Query: 1108 PASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDYAANNE 1143
P + V+ P + T + + + A++ + A
Sbjct: 562 PLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS 618
Query: 1144 DELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182
D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 619 DDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 657
Score = 78.6 bits (192), Expect = 4e-14
Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 22/184 (11%)
Query: 1035 KPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGE 1094
+P D SGA + A V + A + L+L G+++ +L+K + W++G
Sbjct: 423 RPNDPSHAQKPVDSGAPH-----AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGN 477
Query: 1095 LQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV--CQVIAMYDYAANNEDELS 1147
+ Q G FPA++VK++ G + +R + H V + +A ++Y +DELS
Sbjct: 478 C-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELS 532
Query: 1148 FSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIE 1207
FS+G++I + + +W +GE+ G TG+FP N+V+ D S L T P++
Sbjct: 533 FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS-----GANVLSTKVPLK 587
Query: 1208 RKRQ 1211
K++
Sbjct: 588 TKKE 591
Score = 73.6 bits (179), Expect = 1e-12
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 765 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 821
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 444 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 501
Query: 822 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 881
K ++ + V S E + + + VN W + R
Sbjct: 502 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 557
Query: 882 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 913
T + P V P+ G V +L A +AL S+TA+
Sbjct: 558 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 617
Query: 914 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 972
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 618 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 671
Query: 973 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1031
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 672 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 722
Query: 1032 NYVK 1035
NY++
Sbjct: 723 NYIQ 726
Score = 55.8 bits (133), Expect = 2e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 576
Query: 824 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 870
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 577 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 636
Query: 871 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 923
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 637 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 696
Query: 924 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 954
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 697 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
Score = 53.9 bits (128), Expect = 9e-07
Identities = 32/121 (26%), Positives = 62/121 (51%), Gaps = 16/121 (13%)
Query: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSE--RATP-----AFHPV 1129
G ++++LK+ + + + + K G S +K++ P E R+ P A PV
Sbjct: 380 GDVLVMLKQTENNYLECQ-----KGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPV 434
Query: 1130 CQ----VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT 1185
+ ++D+ A D+L+ + G+++ ++ K D DW++G G+FP+NYVK+
Sbjct: 435 DSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII 494
Query: 1186 D 1186
D
Sbjct: 495 D 495
Score = 46.6 bits (109), Expect = 1e-04
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 814
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 677 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 726
Score = 40.0 bits (92), Expect = 0.014
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 682 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 539 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 597
Query: 742 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 801
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 598 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 644
Query: 802 QGNFGWFPCNYVEKMPS-SENEKAVSPK 828
Q G FP +V P+ +++ A+ PK
Sbjct: 645 QDREGIFPAVFVRPCPAEAKSMLAIVPK 672
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 125 bits (314), Expect = 3e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 890 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 947
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 463 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 522
Query: 948 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 1003
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 523 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 570
Query: 1004 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1045
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 571 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 630
Query: 1046 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1105
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 631 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 685
Query: 1106 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1164
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 686 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 744
Query: 1165 WQGEINGVTGLFPSNYVK 1182
GE+ G +G+FP NY++
Sbjct: 745 MSGELMGKSGIFPKNYIQ 762
Score = 92.8 bits (229), Expect = 2e-18
Identities = 96/399 (24%), Positives = 165/399 (41%), Gaps = 70/399 (17%)
Query: 816 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 875
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 333 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 388
Query: 876 KSAFTR--TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN 933
F V P P H + + + D++ +L+Q EN
Sbjct: 389 SQVFKNQDPVLPPRPKPGH---------------------PLYSKYMRGDVLVMLKQTEN 427
Query: 934 WWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYP 991
+ G G S +KII P E R P A + A ++V L+
Sbjct: 428 NYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV-----VLHD 482
Query: 992 YSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGSASKSG 1049
+ + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+ +
Sbjct: 483 FPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKREC 542
Query: 1050 ASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1107
S+ K Y+ ++LS + G++I++ + W +GE++ R G F
Sbjct: 543 VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR-----TGIF 597
Query: 1108 PASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDYAANNE 1143
P + V+ P + T + + + A++ + A
Sbjct: 598 PLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS 654
Query: 1144 DELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182
D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 655 DDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 693
Score = 78.6 bits (192), Expect = 4e-14
Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 22/184 (11%)
Query: 1035 KPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGE 1094
+P D SGA + A V + A + L+L G+++ +L+K + W++G
Sbjct: 459 RPNDPSHAQKPVDSGAPH-----AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGN 513
Query: 1095 LQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV--CQVIAMYDYAANNEDELS 1147
+ Q G FPA++VK++ G + +R + H V + +A ++Y +DELS
Sbjct: 514 C-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELS 568
Query: 1148 FSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIE 1207
FS+G++I + + +W +GE+ G TG+FP N+V+ D S L T P++
Sbjct: 569 FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS-----GANVLSTKVPLK 623
Query: 1208 RKRQ 1211
K++
Sbjct: 624 TKKE 627
Score = 73.6 bits (179), Expect = 1e-12
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 765 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 821
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 480 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 537
Query: 822 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 881
K ++ + V S E + + + VN W + R
Sbjct: 538 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 593
Query: 882 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 913
T + P V P+ G V +L A +AL S+TA+
Sbjct: 594 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 653
Query: 914 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 972
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 654 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 707
Query: 973 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1031
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 708 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 758
Query: 1032 NYVK 1035
NY++
Sbjct: 759 NYIQ 762
Score = 55.8 bits (133), Expect = 2e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 612
Query: 824 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 870
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 613 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 672
Query: 871 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 923
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 673 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 732
Query: 924 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 954
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 733 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
Score = 53.9 bits (128), Expect = 9e-07
Identities = 32/121 (26%), Positives = 62/121 (51%), Gaps = 16/121 (13%)
Query: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSE--RATP-----AFHPV 1129
G ++++LK+ + + + + K G S +K++ P E R+ P A PV
Sbjct: 416 GDVLVMLKQTENNYLECQ-----KGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPV 470
Query: 1130 CQ----VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT 1185
+ ++D+ A D+L+ + G+++ ++ K D DW++G G+FP+NYVK+
Sbjct: 471 DSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII 530
Query: 1186 D 1186
D
Sbjct: 531 D 531
Score = 46.6 bits (109), Expect = 1e-04
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 814
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 713 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 762
Score = 40.0 bits (92), Expect = 0.014
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 682 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 575 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 633
Query: 742 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 801
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 634 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 680
Query: 802 QGNFGWFPCNYVEKMPS-SENEKAVSPK 828
Q G FP +V P+ +++ A+ PK
Sbjct: 681 QDREGIFPAVFVRPCPAEAKSMLAIVPK 708
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 125 bits (314), Expect = 3e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 890 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 947
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 486 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 545
Query: 948 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 1003
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 546 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 593
Query: 1004 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1045
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 594 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 653
Query: 1046 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1105
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 654 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 708
Query: 1106 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1164
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 709 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 767
Query: 1165 WQGEINGVTGLFPSNYVK 1182
GE+ G +G+FP NY++
Sbjct: 768 MSGELMGKSGIFPKNYIQ 785
Score = 95.5 bits (236), Expect = 3e-19
Identities = 99/404 (24%), Positives = 171/404 (42%), Gaps = 57/404 (14%)
Query: 816 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 875
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 333 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 388
Query: 876 KSAFTR--TVSPGSVSPIHG-----QGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVL 928
F V P P H V + + + S + L+ + D++ +L
Sbjct: 389 SQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVS---QNPGELSCKRGDVLVML 445
Query: 929 EQQENWWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEY 986
+Q EN + G G S +KII P E R P A + A ++V
Sbjct: 446 KQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV---- 501
Query: 987 IALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGS 1044
L+ + + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+
Sbjct: 502 -VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 560
Query: 1045 ASKSGASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKR 1102
+ S+ K Y+ ++LS + G++I++ + W +GE++ R
Sbjct: 561 GKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR---- 616
Query: 1103 QKGWFPASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDY 1138
G FP + V+ P + T + + + A++ +
Sbjct: 617 -TGIFPLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSF 672
Query: 1139 AANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182
A D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 673 TAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 716
Score = 80.5 bits (197), Expect = 9e-15
Identities = 66/264 (25%), Positives = 124/264 (46%), Gaps = 32/264 (12%)
Query: 964 PEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEE-ILVTQKDGEWWTGSI 1022
P+ + +K S + + E I S PG+L+ G+ +++ Q + +
Sbjct: 403 PKPGHPLYSKYMLSVPHGIANEDIV-----SQNPGELSCKRGDVLVMLKQTENNYLECQK 457
Query: 1023 GDRSG---IFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYV-----ASGSEQLSL 1074
G+ +G + + P D E S + +KP + A V A + L+L
Sbjct: 458 GEDTGRVHLSQMKIITPLD-EHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNL 516
Query: 1075 APGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV 1129
G+++ +L+K + W++G + Q G FPA++VK++ G + +R + H V
Sbjct: 517 TSGEIVYLLEKIDTDWYRGNC-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCV 571
Query: 1130 --CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDS 1187
+ +A ++Y +DELSFS+G++I + + +W +GE+ G TG+FP N+V+ D
Sbjct: 572 KGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDY 631
Query: 1188 DPSQQWCADLQTLDTMQPIERKRQ 1211
S L T P++ K++
Sbjct: 632 PTS-----GANVLSTKVPLKTKKE 650
Score = 73.6 bits (179), Expect = 1e-12
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 765 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 821
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 503 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 560
Query: 822 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 881
K ++ + V S E + + + VN W + R
Sbjct: 561 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 616
Query: 882 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 913
T + P V P+ G V +L A +AL S+TA+
Sbjct: 617 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 676
Query: 914 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 972
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 677 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 730
Query: 973 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1031
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 731 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 781
Query: 1032 NYVK 1035
NY++
Sbjct: 782 NYIQ 785
Score = 55.8 bits (133), Expect = 2e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 635
Query: 824 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 870
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 636 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 695
Query: 871 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 923
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 696 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 755
Query: 924 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 954
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 756 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
Score = 46.6 bits (109), Expect = 1e-04
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 814
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 736 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 785
Score = 40.0 bits (92), Expect = 0.014
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 682 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 598 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 656
Query: 742 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 801
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 657 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 703
Query: 802 QGNFGWFPCNYVEKMPS-SENEKAVSPK 828
Q G FP +V P+ +++ A+ PK
Sbjct: 704 QDREGIFPAVFVRPCPAEAKSMLAIVPK 731
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 121 bits (303), Expect = 5e-27
Identities = 102/450 (22%), Positives = 221/450 (49%), Gaps = 60/450 (13%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQR-----------EAERK 396
+K+QEEEPQ++ + E+++ ER EL + RQ +QQQR E ER+
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLER--QELRRERQEEEQQQQRLRREQQLRRKQEEERR 315
Query: 397 AQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELER 456
Q+E+ ++++RE QE+ ++QL E+ ++++L R++EEERR+ RRE ++ E+
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375
Query: 457 QRRLEWERIRRQEL-------------LNQKNREQEEIVRLNSKKKNLHLELEALNGKHQ 503
Q R E + R Q+L Q+ R ++++ R ++ L E +H+
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHE 435
Query: 504 QISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQEL-----QEYQNKLIYLVPEK 558
Q + + + K+ Q+ + L ++ + E E ++ +Q+L +E + + + L E+
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE 495
Query: 559 QLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLK----------EQLDALEKETAS 608
+ + + Q + K+ E+E L QRL+ E+ + L K
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 609 KLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQL-YKI 667
K E + +LK + + L +E R ++ E+L ++
Sbjct: 556 KRLEQERREQRLKREQEE-------------RRDQLLKREEERRQQRLKREQEERLEQRL 602
Query: 668 KRDKLKEIERKRLELMQKKKLEDEAAR-----KAKQGKENLWKENLRKEEEEKQKRLQEE 722
KR++++ +E++ + K+ E E R K+++ +E ++ R+++E +++RL+ E
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662
Query: 723 KTQEKIQEEERKAEEKQRKDKDTLKAEEKK 752
+ +E++++ ++ E++R++++ + E+++
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQ 692
Score = 112 bits (281), Expect = 2e-24
Identities = 112/434 (25%), Positives = 208/434 (47%), Gaps = 49/434 (11%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQK-------- 399
Q EE Q++ E++ K R E EK Q L E++Q + +AQ+
Sbjct: 797 QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGL 856
Query: 400 -EKEEWERKQRELQEQEWKKQLE---------------LEKRLEKQRELERQREEERRKD 443
E +E R Q + ++Q+W+ QLE L+++L K+++L ++ EEE +++
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916
Query: 444 IERREAAKQELERQRRLEWERIRRQELLNQKNRE---QEEIVRLNSKKKNLHLELEALNG 500
ER + +QE ERQ R E + + +E L ++ RE ++E R K K L + E L G
Sbjct: 917 -EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975
Query: 501 KHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQL 560
+ + R + R KK ++ EL+ ++Q E E ++ Q+ ++Y+ K E+QL
Sbjct: 976 EEPE--KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQL 1033
Query: 561 LNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQL 620
L E + + ++ +EE Q+ +EQL E+ET + + +
Sbjct: 1034 LREEREKRRLQE---------RERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE 1084
Query: 621 KCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRL 680
+ ++ +L+ +E +QL E+ K +R +L+ R+
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEE 1144
Query: 681 ELMQKKK--LEDEAARKAKQGKENLWK--ENLRKEE-----EEKQKRLQEEKTQEKIQEE 731
E+ Q+++ L +E ++ +Q E ++ E L++EE EE++KR QE + Q + +EE
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEE 1204
Query: 732 ERKAEEKQR-KDKD 744
++ + KQR +D+D
Sbjct: 1205 LQRQKRKQRYRDED 1218
Score = 110 bits (274), Expect = 1e-23
Identities = 103/405 (25%), Positives = 202/405 (49%), Gaps = 42/405 (10%)
Query: 378 LEKRRQALMEQQQREAERK----AQKEKEEWERKQ-------RELQEQEWKKQLELEKRL 426
LE RR+ E+QQ+ ER+ ++E++EW +++ +LQE+E ++Q EL++
Sbjct: 216 LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275
Query: 427 EKQRELERQR-EEERRKDIERREAAKQELERQRRLEWERIRRQELLN--QKNREQEEIVR 483
E+ R+LERQ ER+++ ++++ ++E + +R+ E ER +QE Q+ REQ+E R
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335
Query: 484 LNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQE 543
++ E + Q+ R Q +R +++ ++ E ++ +Q ++++ QQ
Sbjct: 336 EQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQL 395
Query: 544 LQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLK----EQL 599
+E Q + + +Q L + + H++ E+E QRLK E+
Sbjct: 396 RREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERR 455
Query: 600 DALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQL 659
D L++E ++ E + QLK ++ +L L+E E QQ
Sbjct: 456 DWLKREEETERHEQERRKQQLKRDQEEER------------RERWLKLEE--EERREQQE 501
Query: 660 ALEQLYKIKRDKLKEIERKRLE----LMQKKKLEDEAARKAKQGKENLWK--ENLRKEEE 713
EQ + ++++ +E KR E L Q+ + E + R+ ++ +E L K E R E+E
Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561
Query: 714 EKQKRLQEEKTQEKIQ----EEERKAEEKQRKDKDTLKAEEKKRE 754
+++RL+ E+ + + Q EEER+ + +R+ ++ L+ K+ E
Sbjct: 562 RREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606
Score = 108 bits (270), Expect = 3e-23
Identities = 109/435 (25%), Positives = 218/435 (50%), Gaps = 34/435 (7%)
Query: 346 SYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQRE--AERKAQKEK-- 401
++++ QEEE ++ ++ + K+ ERG L R L EQ++R+ AE + Q+E+
Sbjct: 754 AHRQQQEEEQRRDFTWQWQAEEKS--ERGRQRL-SARPPLREQRERQLRAEERQQREQRF 810
Query: 402 --EEWERKQRELQEQEWKKQ---LELEKRLEKQRELERQREEE--RRKDIERREAAKQEL 454
EE E++QR Q +E +K+ LE E++L+++ ++ +EEE ++D ERR + +Q
Sbjct: 811 LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRR 870
Query: 455 ERQRR--LEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDV 512
+++ R LE ER RR+ L K QE+ L +++ L E E L + ++ R +
Sbjct: 871 DQKWRWQLEEERKRRRHTLYAKPALQEQ---LRKEQQLLQEEEEELQREEREKRRRQEQE 927
Query: 513 RLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSN 572
R ++ ++ + E ++Q E E ++ Q+ ++Y+ E+QLL E
Sbjct: 928 RQYREEEQLQQE--EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE-------- 977
Query: 573 TPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQC 632
P+ +K +EE Q+ +EQL E+E + + + + ++ +L+
Sbjct: 978 -PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE 1036
Query: 633 LLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK--LED 690
+E +QL E+ +R +L+ RK EL Q+++ L +
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096
Query: 691 EAARKAKQGKENLWK--ENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKA 748
E ++ +Q +E + E L++EEE+ + +E++ +++++ + R+ EE Q++++ L+
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156
Query: 749 EEKKRETASVLVNYR 763
E +KR + YR
Sbjct: 1157 EPEKRRRQELERQYR 1171
Score = 100 bits (249), Expect = 9e-21
Identities = 103/443 (23%), Positives = 218/443 (49%), Gaps = 48/443 (10%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
Q+++ EE ++ + E++R+ +R E E+RRQ L++ +++E R+ Q +E+ ER+
Sbjct: 600 QRLKREEVER---LEQEERREQRLKREEPE-EERRQQLLKSEEQEERRQQQLRREQQERR 655
Query: 408 QRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIER-REAAKQELER-QRRLEWERI 465
++ L+ +E ++ LE+RL+++ E ER+ +E ++ E+ RE K + + Q +LE E
Sbjct: 656 EQRLKREE--EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713
Query: 466 RRQELLNQK-------NREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQT 518
RQ + + R QE+ + ++ L + E + QQ + +D + Q
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA 773
Query: 519 -QKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPE-------KQLLNERIKNMQF 570
+K+E + E ++ Q +E Q + +PE ++ ER K +QF
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQF 833
Query: 571 SNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVL 630
L ++ L++ E Q+L+E+ D L+++ + S+ + + + ++
Sbjct: 834 ---------LEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR 884
Query: 631 QCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKR-------LELM 683
+ L L ++LR+ Q E+L + +R+K + E++R L+
Sbjct: 885 R-----RHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE 939
Query: 684 QKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERK---AEEKQR 740
+++ L +E ++ +Q +E ++++ + +++E+Q L EE + + QE E+K EE Q+
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKLQQKEEQ-LLGEEPEKRRRQEREKKYREEEELQQ 998
Query: 741 KDKDTLKAEEKKRETASVLVNYR 763
+++ L+ E +KR YR
Sbjct: 999 EEEQLLREEREKRRRQEWERQYR 1021
Score = 99.4 bits (246), Expect = 2e-20
Identities = 102/436 (23%), Positives = 216/436 (49%), Gaps = 56/436 (12%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
++ +++E +++ + E+K+ ER EKRR+ +++ RE E+ Q+ +E+ R+
Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREERE----EKRRRQETDRKFREEEQLLQEREEQPLRR 1355
Query: 408 Q---RELQEQEWKKQLELEKRLEKQRELERQ-------REEERRKDIERREAAKQELERQ 457
Q R+ +E+E + Q + K LE+++ L RQ +EE++ + ER + +Q+ +R+
Sbjct: 1356 QERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK 1415
Query: 458 RRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKH------QQISGRLQD 511
R E +++ RQE + E++++ R ++K L E + +H +Q+ ++
Sbjct: 1416 FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREE 1475
Query: 512 VRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNER-----IK 566
+L +Q + + ++Q + + K +QEL+ + + +L E+QL ++ ++
Sbjct: 1476 QQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQ 1535
Query: 567 NMQFSNTPDSGVSLLH---KKSLEKEELCQ-RLKEQLDALEKETASKLSEMDSFNNQLKC 622
Q + G +K E+E+L Q R ++QL E++ +L E + +
Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQER 1595
Query: 623 GNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDK--LKEIERKRL 680
M+D ++LR QQL E+ K + D+ L+E E ++L
Sbjct: 1596 KFMEDE-------------------QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL 1636
Query: 681 ELMQ--KKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEK 738
+ +K LE+E + ++ ++ L + RK EE+Q + E+ Q + QE +RK E+
Sbjct: 1637 HRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREE 1696
Query: 739 QRKDKDTLKAEEKKRE 754
+++ L+ +E++R+
Sbjct: 1697 EQQ----LRRQERERK 1708
Score = 99.0 bits (245), Expect = 3e-20
Identities = 107/476 (22%), Positives = 230/476 (48%), Gaps = 80/476 (16%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
Q++ +EE ++ E +R+ ER E E+ +Q + + E E++ ++E+E RK
Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRK 962
Query: 408 QRELQEQEWKKQL---ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWER 464
++LQ++E +QL E EKR ++RE + + EEE ++ E + ++E E++RR EWER
Sbjct: 963 DKKLQQKE--EQLLGEEPEKRRRQEREKKYREEEELQQ--EEEQLLREEREKRRRQEWER 1018
Query: 465 IRRQELLNQKNREQEEIVRLNSKKKNL------HLELEALNGKHQQISGRLQDVR----- 513
R++ ++ +E+E+++R +K+ L + E E L + +Q+ G ++ R
Sbjct: 1019 QYRKK--DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 514 -----------------LKKQTQKTELEVLDKQCDLEIMEIKQLQQEL------------ 544
L+++ +K + ++QC E E++Q +++L
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQC-REEEELQQEEEQLLREEREKRRRQE 1135
Query: 545 --QEYQNKLIYLVPEKQLLNE-----RIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKE 597
++Y+ + E+QLL E R + ++ + + ++ L +E+ +R +
Sbjct: 1136 LERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQER 1195
Query: 598 QLDALEKETASKLSEMDSFNNQLKCGNM--------DDSVLQCLLSLLSCLNNLFLLLKE 649
+ E+E + + ++ + ++ +++V + N F L++
Sbjct: 1196 ERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED 1255
Query: 650 LRETYNTQQLALEQLYKIKRDKLKEIERKRLE-----LMQKKKLEDEAARKAKQ--GKEN 702
+ Q L+ L ++++ +E ER+R + ++++LE E ++AK+ K
Sbjct: 1256 SQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQ 1315
Query: 703 LWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-----RKDKDTLKAEEKKR 753
K+ LR+E EEK++R ++T K +EEE+ +E++ R+++D EE+ R
Sbjct: 1316 EEKQLLREEREEKRRR---QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELR 1368
Score = 97.1 bits (240), Expect = 1e-19
Identities = 116/474 (24%), Positives = 226/474 (47%), Gaps = 70/474 (14%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMEL-----EKRRQALMEQQQREAERKAQKEKEEWE 405
QEEE +++ E++R+ ER +L E+R Q L Q++ E ++ + +++
Sbjct: 480 QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539
Query: 406 RKQRELQEQEWKKQLELEKRLEKQRELER-QREEERRKD--IERREAAKQEL---ERQRR 459
R+Q E +EQ K+ E EKRLE++R +R +RE+E R+D ++R E +Q+ E++ R
Sbjct: 540 REQEERREQLLKR--EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER 597
Query: 460 LEWERIRRQEL--LNQKNREQEEIVRLN---SKKKNLHLELEALNGKHQQISGRLQDVRL 514
LE +R++R+E+ L Q+ R ++ + R +++ L E + QQ+ Q+ R
Sbjct: 598 LE-QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656
Query: 515 KKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNM------ 568
++ ++ E E L+++ E E ++ +QEL E E++ ERIK+
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERR-EQELAE---------EEQEQARERIKSRIPKWQW 706
Query: 569 QFSNTPDSGVSLLH---------KKSLEKEELCQRLKEQLDALEKETASKLSEMDS---- 615
Q + D+ S ++ ++ E+EE +R + +L E+E A + + +
Sbjct: 707 QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRD 766
Query: 616 FNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEI 675
F Q + + Q L + L+E RE +QL E+ + ++ L E
Sbjct: 767 FTWQWQAEEKSERGRQRLSARPP--------LREQRE----RQLRAEERQQREQRFLPEE 814
Query: 676 ERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKA 735
E K Q+++ E E +E + + E+ ++LQEE+ + +E R++
Sbjct: 815 EEKEQRRRQRREREKEL---------QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRS 865
Query: 736 EEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEK 789
+E++R K + EE+++ L AL + R ++ + +Q +E+
Sbjct: 866 QEQRRDQKWRWQLEEERKRRRHTLYAKPALQE-QLRKEQQLLQEEEEELQREER 918
Score = 96.7 bits (239), Expect = 1e-19
Identities = 100/439 (22%), Positives = 220/439 (50%), Gaps = 37/439 (8%)
Query: 344 LPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQK-EKE 402
L Q++ ++ Q+K E+++ ERG + R + E++Q ER+ Q+ ++
Sbjct: 1518 LEEEQQLHRQQRQRKF--LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQ 1575
Query: 403 EWERKQRELQEQEWKKQLELEKRLEKQRELERQR-EEERRKDIERREAAKQELERQRRLE 461
E +RK R L+EQ+ ++Q + K +E +++L RQ +++ R++ +R+ ++L ++R E
Sbjct: 1576 ERDRKFR-LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER--E 1632
Query: 462 WERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKT 521
+++ RQE ++K E+E +R +++ L + + + +Q+ ++ +L++Q +
Sbjct: 1633 EQQLHRQER-DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691
Query: 522 ELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLL 581
+ ++Q + E K LQ+E Q + +L E++ L + + Q
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQER------ 1745
Query: 582 HKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLN 641
++K LE+E+L +EQ +E K E + + ++ L+ S +
Sbjct: 1746 YRKILEEEQLRPEREEQ-QLRRQERDRKFREEEQLRQE-----REEQQLRSQES-----D 1794
Query: 642 NLFLLLKELRETYNTQQLALEQL---YKIKRDKLK---EIERKRLELMQKKKLEDEAA-- 693
F ++LR+ QQL +Q Y+ + ++L+ + +R R E ++ + E++ A
Sbjct: 1795 RKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQ 1854
Query: 694 RKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKD----TLKAE 749
K+++ ++ LW+E +K +E++++L+EE + + +EE+R + + K ++ E
Sbjct: 1855 EKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914
Query: 750 EKKRETASVLVNYRALYPF 768
+ ASV V LY +
Sbjct: 1915 PGTHQFASVPVRSSPLYEY 1933
Score = 95.5 bits (236), Expect = 3e-19
Identities = 95/412 (23%), Positives = 212/412 (51%), Gaps = 33/412 (8%)
Query: 364 EDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQE-----WKK 418
+++++A + L+ RRQ E Q+R R Q E+E +R++++ QEQE ++
Sbjct: 96 DEEKRARCDGKESLLQDRRQE--EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEE 153
Query: 419 QLELEKRLEKQ------RELERQREE-----ERRKDIERREAAKQELERQRRLEWERIRR 467
Q E ++RLE++ EL RQR+E ERR + E+ ++ K E + + E++RR
Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGH-ETEEFPDEEQLRR 212
Query: 468 QEL--LNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEV 525
+EL L +K RE+++ R ++ + E E + ++ R ++ +L+++ + + E+
Sbjct: 213 RELLELRRKGREEKQQQR-RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQREL 271
Query: 526 LDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKS 585
+++ L +E ++L++E QE + + L E+QL R + + + ++
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL--RRKQEEERREQQEERREQQERRE 329
Query: 586 LEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFL 645
++E Q+L+ + + ++ + E + QL+ ++ Q L
Sbjct: 330 QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE--Q 387
Query: 646 LLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWK 705
L+ ++ QQL EQ + ++ +E + +R + +++++ E+ +K +Q + +
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR---E 444
Query: 706 ENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDT----LKAEEKKR 753
+ L++E+EE++ L+ E+ E+ ++E RK + K+ ++++ LK EE++R
Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496
Score = 94.7 bits (234), Expect = 5e-19
Identities = 97/429 (22%), Positives = 207/429 (48%), Gaps = 32/429 (7%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNME--LEKRRQALMEQQQREAERKAQKEKEEWERKQ 408
QEE Q++L +++R+ +R E LE+R + E+++RE E +++++ ER +
Sbjct: 639 QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIK 698
Query: 409 RELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQ 468
+ + +W+ + E + R K R++E +RR R+E ++ R+ L+W+ R
Sbjct: 699 SRIPKWQWQLESEADARQSKVYSRPRKQEGQRR----RQEQEEKRRRRESELQWQEEER- 753
Query: 469 ELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGR--LQDVRLKKQTQKTELEVL 526
+R+Q+E + E ++ G+ Q++S R L++ R ++Q + E +
Sbjct: 754 -----AHRQQQEEEQRRDFTWQWQAEEKSERGR-QRLSARPPLREQR-ERQLRAEERQQR 806
Query: 527 DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSL 586
+++ E E +Q +++ +E + +L +L E+Q L R + Q D ++
Sbjct: 807 EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ-LQRRERAQQLQEEEDGLQEDQERRRS 865
Query: 587 EKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLL 646
+++ Q+ + QL+ K L + QL+ + +LQ L
Sbjct: 866 QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR---KEQQLLQEEEEELQREEREKRR 922
Query: 647 LKELRETYNTQ---QLALEQLYKIKRDKLKEIER-------KRLELMQKKKLEDEAARKA 696
+E Y + Q EQL + +R+K + ER K+L+ +++ L +E ++
Sbjct: 923 RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982
Query: 697 KQGKENLWK--ENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRE 754
+Q +E ++ E L++EEE+ + +E++ +++ + + RK +E Q++++ L+ E +KR
Sbjct: 983 RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042
Query: 755 TASVLVNYR 763
YR
Sbjct: 1043 LQERERQYR 1051
Score = 94.7 bits (234), Expect = 5e-19
Identities = 106/422 (25%), Positives = 201/422 (47%), Gaps = 54/422 (12%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEW--- 404
+K +EEE Q L D++ E+ E+ R+ L E+QQ ER + +EE
Sbjct: 1414 RKFREEEQQ--LSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ 1471
Query: 405 ERKQRELQEQEW-KKQLELEKRLEKQRELERQREEERRKDIERRE--AAKQELERQRRL- 460
ER++++L QE +K LE E++L +Q + RE+E R R+ +Q+L RQ+R
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQR 1531
Query: 461 ----EWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKK 516
E +++RRQE Q+ ++++ R +++ L E E QQ+S + +D + +
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFR---EEEQLRQERE-----EQQLSRQERDRKFRL 1583
Query: 517 QTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDS 576
+ QK + +++ + ++++ + + Q Q + ++QLL ER + Q
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER-EEQQLHRQERD 1642
Query: 577 GVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSL 636
L + L ++E Q+L+ D +E L E + QL+ D
Sbjct: 1643 RKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE--QQLRRQERD---------- 1690
Query: 637 LSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKA 696
++ RE QQL ++ +R L+E ++ R + +++K E+E R+
Sbjct: 1691 -----------RKFRE--EEQQLRRQER---ERKFLQEEQQLRRQELERKFREEEQLRQE 1734
Query: 697 KQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEE----KQRKDKDTLKAEEKK 752
+ ++ +E RK EE+Q R + E+ Q + QE +RK E +Q +++ L+++E
Sbjct: 1735 TEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESD 1794
Query: 753 RE 754
R+
Sbjct: 1795 RK 1796
Score = 93.6 bits (231), Expect = 1e-18
Identities = 97/425 (22%), Positives = 202/425 (47%), Gaps = 39/425 (9%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQR--EAERKAQKEKEEWE 405
Q +QE E Q+ E RK E + ++R + EQ+ R E ERK +E+++
Sbjct: 1468 QLLQEREEQQLHRQ--ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLH 1525
Query: 406 RKQRE---LQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEW 462
R+QR+ LQE++ ++ E ++ + R+ + + EE+ R++ E ++ ++QE +R+ RLE
Sbjct: 1526 RQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE 1585
Query: 463 ERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTE 522
+++RRQE +K E E+ +R ++ L E + + +Q+ ++ +L +Q + +
Sbjct: 1586 QKVRRQE-QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRK 1644
Query: 523 L-------------EVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQ 569
+ L D + E +QL QE +E Q L +++ R + Q
Sbjct: 1645 FLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQ-----LRRQERDRKFREEEQQ 1699
Query: 570 FSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSV 629
L ++ L ++EL ++ +E+ ++ +L + + L+ +
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759
Query: 630 LQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERK-RLELMQKKKL 688
+ L + F ++LR+ QQL + +E +RK R E +++
Sbjct: 1760 EEQQLRRQE-RDRKFREEEQLRQEREEQQL-----------RSQESDRKFREEEQLRQER 1807
Query: 689 EDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKA 748
E++ R ++ + W+E + EE++Q+ QE Q + +E+ E+ +R++++ +
Sbjct: 1808 EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQE 1867
Query: 749 EEKKR 753
EE+KR
Sbjct: 1868 EEQKR 1872
Score = 90.5 bits (223), Expect = 9e-18
Identities = 94/433 (21%), Positives = 207/433 (47%), Gaps = 73/433 (16%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNM---ELEKRRQALMEQQQREAERKAQKEKEEWERK 407
+E+ +++L + ++ + E + E EKRR+ +E+Q RE E + Q+E+E+ R+
Sbjct: 1128 REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYRE-EEELQQEEEQLLRE 1186
Query: 408 QRELQEQEWKKQLELEKRLEKQRELERQREEERRKDI------ERREAAK--------QE 453
++E + QE ++Q E+ L++Q+ +R R+E++R D+ E+ A + +E
Sbjct: 1187 EQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE 1246
Query: 454 LERQRRLEWERIR-------RQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS 506
E+ R+LE ++R Q LL ++ E R ++++ H E + +Q
Sbjct: 1247 NEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKE 1306
Query: 507 GRLQDVRLKKQTQKTELEVLDK----QCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLN 562
+ +D + +++ Q E +K + D + E +QL QE +E L +++
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE--QPLRRQERDRKFRE 1364
Query: 563 ERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKC 622
E +++ + +K LE+E+ +R + + L++E QL+C
Sbjct: 1365 EELRHQEQG-----------RKFLEEEQRLRRQERERKFLKEE------------QQLRC 1401
Query: 623 GNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLEL 682
+ + Q ++ + QQL+ ++ + R++ +++ R+ E
Sbjct: 1402 QEREQQLRQD---------------RDRKFREEEQQLSRQERDRKFREEEQQVRRQERE- 1445
Query: 683 MQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKD 742
+K LE+E + ++ ++ +E L +E EE+Q QE + +E++ + +E+ RK
Sbjct: 1446 --RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKF 1503
Query: 743 KD-TLKAEEKKRE 754
++ L+++E +R+
Sbjct: 1504 REQELRSQEPERK 1516
Score = 87.0 bits (214), Expect = 1e-16
Identities = 103/424 (24%), Positives = 199/424 (46%), Gaps = 32/424 (7%)
Query: 349 KMQEEEPQKKLPVTFEDK-RKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
K QEEE + + + E + R+ ER L++ + +EQ++RE K ++E+ +
Sbjct: 520 KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579
Query: 408 QRELQEQEWKKQLELEKRLE---KQRELERQREEERRKDIERREAAKQELERQR-RLEWE 463
+RE + ++ + + E E+RLE K+ E+ER +EERR+ +RE ++E +Q + E +
Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQ 639
Query: 464 RIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTEL 523
RRQ+ Q REQ+E K++ LE Q++ ++ R +++ + E
Sbjct: 640 EERRQQ---QLRREQQERREQRLKREEEEERLE------QRLKREHEEERREQELAEEEQ 690
Query: 524 EVLDKQCDLEIMEIK-QLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLH 582
E ++ I + + QL+ E Q+K +Y P KQ +R + Q L
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQSK-VYSRPRKQ-EGQRRRQEQEEKRRRRESELQW 748
Query: 583 KKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNN 642
++ Q +++ D + A + SE + + Q
Sbjct: 749 QEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQ 808
Query: 643 LFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK--LEDEAARKAKQGK 700
FL +E +E Q+ E+ + ++ + R+R + +Q+++ L+++ R+ Q +
Sbjct: 809 RFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQ 868
Query: 701 ENLWKENLRKEEEEKQKR--------LQEE--KTQEKIQEEERKAEEKQRKDKDTLKAEE 750
K + EEE K++R LQE+ K Q+ +QEEE EE QR++++ + +E
Sbjct: 869 RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE---EELQREEREKRRRQE 925
Query: 751 KKRE 754
++R+
Sbjct: 926 QERQ 929
Score = 84.7 bits (208), Expect = 5e-16
Identities = 101/428 (23%), Positives = 198/428 (46%), Gaps = 38/428 (8%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
+++Q+EE Q L E +R+ ER E E+ +Q E++Q E + ++ ++E ER+
Sbjct: 1084 EELQQEEEQL-LREEPEKRRRQERERQCREEEELQQ---EEEQLLREEREKRRRQELERQ 1139
Query: 408 QRELQEQEWKKQLELEKRLEKQR--ELERQREEERRKDIERREAAKQELERQRRLEWER- 464
RE +E + +++ L + EK+R ELERQ EE E + ++E E+ RR E ER
Sbjct: 1140 YREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK-RRQERERQ 1198
Query: 465 IRRQELLNQKNREQEEIVRLNSKKKNLHLELEA------------LNGKHQQISGRLQDV 512
R +E L ++ R+Q R ++ +L + E G+ + +L+D
Sbjct: 1199 YREEEELQRQKRKQR--YRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDS 1256
Query: 513 RLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSN 572
+L+ + + +L+ L L + + +QE + +Q + + E+QL E K + +
Sbjct: 1257 QLRDRQSQQDLQHL-----LGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311
Query: 573 TPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQC 632
L ++ E+EE +R + E+E + E Q + + L+
Sbjct: 1312 RKSQEEKQLLRE--EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRH 1369
Query: 633 LLSLLSCLNNLFLLLKELRE---TYNTQQLAL----EQLYKIKRDKLKEIERKRLELMQK 685
L L ++ RE QQL +QL + + K +E E++ +
Sbjct: 1370 QEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERD 1429
Query: 686 KKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDT 745
+K +E + +Q +E + E ++ +E+ ++ +EE ++ +QE E + +Q +D+
Sbjct: 1430 RKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE--EQLLQEREEQQLHRQERDRKF 1487
Query: 746 LKAEEKKR 753
L+ E++ R
Sbjct: 1488 LEEEQQLR 1495
Score = 84.7 bits (208), Expect = 5e-16
Identities = 112/436 (25%), Positives = 206/436 (47%), Gaps = 51/436 (11%)
Query: 345 PSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKE---- 400
P ++ QE E Q + E+ ++ + E EKRR+ +E+Q RE E Q+E
Sbjct: 1098 PEKRRRQERERQCREE---EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154
Query: 401 KEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRL 460
+EE E+++R+ E++++++ EL+ +++ +L R+ +E+RR++ ER+ ++EL+RQ+R
Sbjct: 1155 REEPEKRRRQELERQYREEEELQ---QEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211
Query: 461 EWERI--RRQELLNQKNREQEEIVRLNS-----KKKNLHLELEALNGKHQQISGRLQDVR 513
+ R +R +L Q E+E VR N ++ +LE + +Q LQ +
Sbjct: 1212 QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271
Query: 514 LKKQTQKTELEVLD-KQCDLEIMEIKQLQQELQ-EYQNKLIYLVPEKQLLNERIKNMQFS 571
++Q + E E +Q D E +QL++E Q E + + EKQLL E + +
Sbjct: 1272 GEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331
Query: 572 NTPDSGVSLLHKKSLEKEELCQRLKEQ-LDALEKETASKLSEMDSFNNQLKCGNMDDSVL 630
D +K E+E+L Q +EQ L E++ + E+ K
Sbjct: 1332 QETD-------RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK--------- 1375
Query: 631 QCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRD-KLKEIERKRLELMQKKKLE 689
L L K L+E + EQ + RD K +E E++ + +K
Sbjct: 1376 --FLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFR 1433
Query: 690 DEAARKAKQGKENLWKEN---LRKE------EEEKQKRLQEEKTQEKIQEEERKAEEKQ- 739
+E + +Q +E + E LR+E EEE+ + +EE+ + + + + EE+Q
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ 1493
Query: 740 --RKDKDTLKAEEKKR 753
R+++D E++ R
Sbjct: 1494 LRRQERDRKFREQELR 1509
Score = 81.6 bits (200), Expect = 4e-15
Identities = 98/418 (23%), Positives = 187/418 (44%), Gaps = 40/418 (9%)
Query: 373 RGNMELEKRRQALMEQQQREAERKAQK---------EKEEWERKQRELQEQEWKKQLELE 423
R + + L EQQ+R+ E++ ++ E+E+ ER++++ ++ +K E +
Sbjct: 1259 RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK 1318
Query: 424 KRLEKQRELERQREEERRKDIERREAAKQELERQ--RRLEWER-IRRQELLNQ----KNR 476
+ L ++RE E++R +E + E QE E Q RR E +R R +EL +Q K
Sbjct: 1319 QLLREERE-EKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFL 1377
Query: 477 EQEEIVRLNSKKKNLHLELEAL--NGKHQQI------SGRLQDVRLKKQTQKTELEVLDK 528
E+E+ +R +++ E + L + QQ+ R ++ +L +Q + + ++
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437
Query: 529 QCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEK 588
Q + E K L++E Q Q + E+QLL ER + Q L ++ L +
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQER-EEQQLHRQERDRKFLEEEQQLRR 1496
Query: 589 EELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLK 648
+E ++ +EQ ++ L E + Q + Q K
Sbjct: 1497 QERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK 1556
Query: 649 ELRETYNTQQLALEQLYKIKRDKLKEIERK--RLELMQKKKLEDEAARKAKQGKENLWKE 706
E Q+ +QL + +RD+ +E + R + ++K +EDE + ++G++ L +E
Sbjct: 1557 FREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE 1616
Query: 707 NLRKEEEEKQKRLQEEKTQEKIQEEERK------------AEEKQRKDKDTLKAEEKK 752
RK E++Q + E+ Q QE +RK E++ R D+D EE++
Sbjct: 1617 RDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQ 1674
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 105 bits (262), Expect = 3e-22
Identities = 131/573 (22%), Positives = 252/573 (43%), Gaps = 98/573 (17%)
Query: 341 NGTLPSYQKMQEEEPQKKLP-------VTFEDKRKANYERGNMELEKRRQALMEQQQREA 393
NG + S + QEEE ++ + EDK +A ER +E E+R + EQ ++ A
Sbjct: 230 NGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIA 289
Query: 394 ERKAQKEKEE----WERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIER--- 446
+ +A+ E EE ER++RE +E+E + E EKR ++R+ R +EEE+R ER
Sbjct: 290 DERARIEAEEKAAAQERERREAEERE--RMREEEKRAAEERQ--RIKEEEKRAAEERQRI 345
Query: 447 REAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS 506
+E K+ E ++R++ E R E + E+EE ++ +K+N LE + + +I
Sbjct: 346 KEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIK 405
Query: 507 GRLQDVRL--------KKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEK 558
G + ++ K Q K + VL KQ + + +++ +++LQE + ++
Sbjct: 406 GEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTF----KKE 461
Query: 559 QLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNN 618
++ +E+IK K KEE +K +D + T K + +
Sbjct: 462 EIKDEKIK----------------KDKEPKEE----VKSFMDRKKGFTEVKSQNGEFMTH 501
Query: 619 QLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERK 678
+LK S S+ + +E Q+ + +L+E+ R+
Sbjct: 502 KLKHTENTFSRPGGRASV------------DTKEAEGAPQVEAGK-------RLEELRRR 542
Query: 679 RLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEK 738
R E + E+ K KQ + L E L+K+ EE++K L+EE+ + K +E +RK E+
Sbjct: 543 RGE----TESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREE 598
Query: 739 QRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFN----SGDIIQVDEKTVGEP 794
+ K + + E ++ E A R P + + D+ F G ++++E+
Sbjct: 599 EEKRRLKEEIERRRAEAA----EKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERA---- 650
Query: 795 GWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPA 854
+L S Q + G V+ + + + + + ++ ++P +S+ P
Sbjct: 651 EFLNKSVQKSSG------VKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPV 704
Query: 855 SVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGS 887
+N + + W+K + F+ + G+
Sbjct: 705 PAEGVRN-------IKSMWEKGNVFSSPTAAGT 730
Score = 72.8 bits (177), Expect = 2e-12
Identities = 95/391 (24%), Positives = 182/391 (46%), Gaps = 81/391 (20%)
Query: 427 EKQRELERQREEERRKDIER-----REAAKQELERQRRLEWERIRRQELLNQKNREQEEI 481
E++REL RQ+ EE R + ER + ++E R+RR R RQE L QK +E+E +
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERR----RRARQERLRQK-QEEESL 59
Query: 482 VRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLE-------- 533
++ + +E+ A N + D K T T++E D+ LE
Sbjct: 60 GQVTDQ-----VEVNAQNS--------VPDEEAKTTTTNTQVEGDDEAAFLERLARREER 106
Query: 534 ----IMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKE 589
+ E + Q+E +P +++ N+ +N + + + S + +E+
Sbjct: 107 RQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAEN-ETTEKEEKSESRQERYEIEET 165
Query: 590 ELCQRLKEQ---LDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLL----------SL 636
E + ++ DA E + K E + + K G++ ++ ++ ++ ++
Sbjct: 166 ETVTKSYQKNDWRDAEENKKEDKEKEEEE-EEKPKRGSIGENQVEVMVEEKTTESQEETV 224
Query: 637 LSCLNNLFLLLKELRETYNTQQLALE------------QLYKIKRDKLKEIERKRLELMQ 684
+ L N + +E ++ +Q + E + + +R +L+ ER+R++ Q
Sbjct: 225 VMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
Query: 685 KKKLEDEAAR---------KAKQGKENLWKENLRKEE----EEKQKRLQEEK----TQEK 727
KK+ DE AR + ++ +E +E +R+EE EE+Q+ +EEK +++
Sbjct: 285 DKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR 344
Query: 728 IQEEE-RKAEEKQR-KDKDTLKAEEKKRETA 756
I+EEE R AEE+QR K+++ AEE++R A
Sbjct: 345 IKEEEKRAAEERQRIKEEEKRAAEERQRARA 375
Score = 65.1 bits (157), Expect = 4e-10
Identities = 100/447 (22%), Positives = 188/447 (42%), Gaps = 56/447 (12%)
Query: 325 ELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKK--------LPVTFEDKRKANYERGNM 376
E V S++ D+ +K +EEE + K + V E+K + E +
Sbjct: 166 ETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVV 225
Query: 377 ELEKRRQALMEQQQREAERKAQKEK----EEWERKQRELQEQEWKKQLELEKRLEKQREL 432
K Q E+ ++E ER+ ++ E+ E + +E E E + +LE E+R + E
Sbjct: 226 MSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAE-RARLEAEERERIKAEQ 284
Query: 433 ERQREEERRKDIERREAAKQELERQRRLEWERIRRQE--LLNQKNREQEEIVRLNSKKKN 490
+++ +ER + +AA QE ER+ E ER+R +E ++ R +EE R +++
Sbjct: 285 DKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR 344
Query: 491 LHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNK 550
+ E + + Q+I + ++ R ++ Q+ E +K E KQL+++ Q
Sbjct: 345 IKEEEKRAAEERQRI--KEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQET 402
Query: 551 LIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKL 610
I +Q + + N + + ++L K+ EK Q +E+L +K T K
Sbjct: 403 KIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQE-DKPTFKK- 460
Query: 611 SEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRD 670
++K D+ + + KE +E + + ++
Sbjct: 461 -------EEIK----DEKIKKD---------------KEPKEEVKS--------FMDRKK 486
Query: 671 KLKEIERKRLELMQKKKLEDEAARKAKQGKENL-WKENLRKEEEEKQKRLQEEKTQEKIQ 729
E++ + E M K E G+ ++ KE + E KRL+E + +
Sbjct: 487 GFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGET 546
Query: 730 EEERKAEEKQRKDKDTLKAEE--KKRE 754
E E + KQ++ + L+ EE KKRE
Sbjct: 547 ESEEFEKLKQKQQEAALELEELKKKRE 573
Score = 62.0 bits (149), Expect = 3e-09
Identities = 96/481 (19%), Positives = 194/481 (40%), Gaps = 105/481 (21%)
Query: 351 QEEEPQKKLPVTFEDKRKAN--YERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQ 408
+EE QK+L E +++ + ++ L RR M+ E E ++EK E +++
Sbjct: 103 REERRQKRLQEALERQKEFDPTITDASLSLPSRR---MQNDTAENETTEKEEKSESRQER 159
Query: 409 RELQEQEWKKQLELEKRLEKQ--RELERQREEERRKDIERREAAKQELERQRRLEWERIR 466
E++E E + K +K R+ E ++E++ K+ E E K+ + ++E
Sbjct: 160 YEIEETE-----TVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVE----- 209
Query: 467 RQELLNQKNRE-QEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEV 525
++ +K E QEE V ++ K NG+ + ++ R + + + E
Sbjct: 210 --VMVEEKTTESQEETVVMSLK-----------NGQISSEEPKQEEEREQGSDEISHHEK 256
Query: 526 LDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKS 585
++++ D E E ++ + E +E ERIK Q D + ++
Sbjct: 257 MEEE-DKERAEAERARLEAEE---------------RERIKAEQDKKIADERARIEAEEK 300
Query: 586 LEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFL 645
+E +R E+ + + +E E + K
Sbjct: 301 AAAQERERREAEERERMREEEKRAAEERQRIKEEEKRA---------------------- 338
Query: 646 LLKELRETYNTQQLALEQLYKIKRDKLK---EIERKRLELMQKKKLEDEAARKAKQGKEN 702
+E + ++ A E+ +IK ++ + E +R R E +K K+E++ K + K++
Sbjct: 339 -AEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH 397
Query: 703 LWKENLRKEEEEKQ---------KRLQEEKTQ-------------------EKIQEEERK 734
+E K E+ +Q K+ QE+K Q EK+QE++
Sbjct: 398 AMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPT 457
Query: 735 AEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEP 794
++++ KD+ K +E K E S + + +++N + M+ ++ E T P
Sbjct: 458 FKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHK----LKHTENTFSRP 513
Query: 795 G 795
G
Sbjct: 514 G 514
Score = 56.6 bits (135), Expect = 1e-07
Identities = 84/448 (18%), Positives = 186/448 (41%), Gaps = 79/448 (17%)
Query: 346 SYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKR-------------RQALMEQQQRE 392
+YQ+ ++E + E +R+A ER + E+ + ++ +++ +
Sbjct: 26 AYQRNDDDEEE----AARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKT 81
Query: 393 AERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRE-----------LERQREEERR 441
Q E ++ L +E ++Q L++ LE+Q+E L +R +
Sbjct: 82 TTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDT 141
Query: 442 KDIERREAAKQELERQRRLEWERIRRQELLNQKN--REQEEIVRLNSKKKNLHLELEALN 499
+ E E ++ RQ R E E QKN R+ EE N K+ E E
Sbjct: 142 AENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEE----NKKEDKEKEEEEEEK 197
Query: 500 GKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQ 559
K I +V ++++T +++ E + +M +K Q +E + + E++
Sbjct: 198 PKRGSIGENQVEVMVEEKTTESQEETV-------VMSLKNGQISSEEPKQE-----EERE 245
Query: 560 LLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQ 619
++ I + + D + + LE EE +R+K + D K+ A + + +++ +
Sbjct: 246 QGSDEISHHEKMEEEDKERAEAERARLEAEER-ERIKAEQD---KKIADERARIEA---E 298
Query: 620 LKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKR 679
K + + +E ++ A E+ +IK ++ + E ++
Sbjct: 299 EKAAAQERERREA---------------EERERMREEEKRAAEERQRIKEEEKRAAEERQ 343
Query: 680 LELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ 739
++K+ +E R ++ K + + EEE++ +++E+K ++++E++ +E +
Sbjct: 344 RIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETK 403
Query: 740 RKDK-----------DTLKAEEKKRETA 756
K + + KA+E K +TA
Sbjct: 404 IKGEKVEQKIEGKWVNEKKAQEDKLQTA 431
Score = 43.1 bits (100), Expect = 0.002
Identities = 37/153 (24%), Positives = 73/153 (47%), Gaps = 17/153 (11%)
Query: 332 RGGKQIDSINGTLPSYQKMQEEE----PQKKLPVTFEDKRKANYERGNMELEKRRQALME 387
+G ++ S NG +++ E P + V ++ A LE+ R+
Sbjct: 486 KGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRR---- 541
Query: 388 QQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERR 447
R+ + E EE+E+ +++ QE + + EL+K+ E++R++ + EE+RRK E
Sbjct: 542 -------RRGETESEEFEKLKQKQQEAALELE-ELKKKREERRKV-LEEEEQRRKQEEAD 592
Query: 448 EAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
++E E++R E RR E ++ + E+
Sbjct: 593 RKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 625
Score = 33.5 bits (75), Expect = 1.3
Identities = 37/163 (22%), Positives = 76/163 (46%), Gaps = 27/163 (16%)
Query: 329 PSFRGGKQIDSIN---GTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQAL 385
P GK+++ + G S + + ++ Q++ + E+ +K E+RR+ L
Sbjct: 528 PQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR--------EERRKVL 579
Query: 386 MEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL--ELEKR----LEKQRELERQREEE 439
E++QR + Q+E + R+L+E+E K++L E+E+R EK++++ +
Sbjct: 580 EEEEQR----RKQEEAD------RKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSD 629
Query: 440 RRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIV 482
+K + L+ + R E+ Q+ K+ Q IV
Sbjct: 630 DKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIV 672
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 103 bits (256), Expect = 1e-21
Identities = 100/441 (22%), Positives = 211/441 (47%), Gaps = 71/441 (16%)
Query: 343 TLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKE 402
TL QEEE + E ++K + M ++ R E + RE E K +++++
Sbjct: 231 TLQEEMWRQEEELR-------EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEK 283
Query: 403 EWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEW 462
+++EL+EQE K+L +K+L +Q E +++EE+ + E+ ++++ RQ W
Sbjct: 284 RLREQEKELREQE--KELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 341
Query: 463 ERIRRQELLNQKNREQEEIV-----RLNSKKKNLH-----LELEALNGKHQQISGRLQDV 512
E+ ++ QK R+QEE + RL K++ + E E + ++I R + +
Sbjct: 342 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKM 401
Query: 513 RLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSN 572
R +++T + + E + KQ E +QE +E+Q + + PE++ E++ +
Sbjct: 402 REEEETMREQEEKMQKQ------EENMWEQEEKEWQQQRL---PEQK---EKLWEQEKMQ 449
Query: 573 TPDSGVSLLHKKSLEKEELC---------QRLKEQLDAL-EKETASKLSEMDSFNNQLKC 622
+ + +K ++EE+ ++++EQ D + E+E + E ++ + +
Sbjct: 450 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM 509
Query: 623 GNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLEL 682
D+ L+E E Q+ +Q K++ +K + + K+
Sbjct: 510 WEQDER------------------LREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWD 551
Query: 683 MQKKKLEDEAAR----KAKQGKENLWKENLRKEEEEKQKRLQEEK---TQEKIQEEERKA 735
++K E+E R K ++ +E + ++ + +E+E++ R QEEK +EK+QE+E K
Sbjct: 552 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKM 611
Query: 736 EEKQRK-----DKDTLKAEEK 751
E++ K ++D ++ +E+
Sbjct: 612 WEQEEKMWEQEEEDKMQEQEE 632
Score = 95.1 bits (235), Expect = 4e-19
Identities = 100/438 (22%), Positives = 204/438 (46%), Gaps = 78/438 (17%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQ------------ 398
QEE+ Q++ +E + K + M ++ R E+Q RE E+K +
Sbjct: 308 QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER 367
Query: 399 -KEKEEWERKQRELQEQEWKKQ-----LELEKRLEKQRELERQREEERRK------DIER 446
+EKEE R+Q ++ EQE K Q E EK++ ++ E R++EE+ +K + E
Sbjct: 368 LREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE 427
Query: 447 REAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS 506
+E +Q L Q+ WE+ + QE +K EQEE +R + E + G+ +++
Sbjct: 428 KEWQQQRLPEQKEKLWEQEKMQEQ-EEKIWEQEEKIR----------DQEEMWGQEKKMW 476
Query: 507 GRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIK 566
+ + + Q + E ++ D++ + E + +Q+ + + K + +K++ + K
Sbjct: 477 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQD-ERLREKEERMREQKKMWQQEEK 535
Query: 567 NMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMD 626
+ T + KK+ ++EE +++E+ E+E + E + K +
Sbjct: 536 MREEKKTQEQ-----EKKTWDQEE---KMREEERMREREKKMREEEEMMREQEEKMQEQE 587
Query: 627 DSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKK 686
+ ++E E Q+ +++ + +K+ E E K E ++
Sbjct: 588 EK------------------MREQEEKMWEQEEKMQE----QEEKMWEQEEKMWEQEEED 625
Query: 687 KLED------EAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQ---EKIQEEERK--- 734
K+++ E K ++ +E +W++ + E+E++ R QEEK Q EK++E+E K
Sbjct: 626 KMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQG 685
Query: 735 AEEKQRKDKDTLKAEEKK 752
EEK R+ ++ ++ +E+K
Sbjct: 686 QEEKMREQEEKMRGQEEK 703
Score = 89.0 bits (219), Expect = 3e-17
Identities = 99/416 (23%), Positives = 208/416 (50%), Gaps = 36/416 (8%)
Query: 361 VTFEDKRKANYE-RGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRE-LQEQEWKK 418
+T E+ +K N E + + L + ++ ++ +E +RK ++ K + Q LQE+ W++
Sbjct: 180 ITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ 239
Query: 419 QLEL---EKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKN 475
+ EL EK++ KQ E + R+EER ++ +E +E E + R + +R+R QE ++
Sbjct: 240 EEELREQEKKIRKQEE-KMWRQEERLRE---QEGKMREQEEKMRRQEKRLREQE---KEL 292
Query: 476 REQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIM 535
REQE+ +R K + +++ K + ++++ K Q+ L +KQ +
Sbjct: 293 REQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 352
Query: 536 EIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRL 595
+++ ++ + E Q++ + E+ E++ + + + KK E+EE +
Sbjct: 353 KMRDQEERMWE-QDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEE---TM 408
Query: 596 KEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYN 655
+EQ + ++K+ + + + Q + + + + + + E E
Sbjct: 409 REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE-----QEKMQEQEEKIWEQEEKIR 463
Query: 656 TQQLALEQLYKI-KRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWK--ENLRKEE 712
Q+ Q K+ +++K++E E + E Q++K+ D+ + Q +E +W+ E LR++E
Sbjct: 464 DQEEMWGQEKKMWRQEKMREQEDQMWE--QEEKMRDQEQKMWDQ-EERMWEQDERLREKE 520
Query: 713 E--EKQKRL--QEEKTQE--KIQEEERKA---EEKQRKDKDTLKAEEKKRETASVL 759
E +QK++ QEEK +E K QE+E+K EEK R+++ + E+K RE ++
Sbjct: 521 ERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMM 576
Score = 87.4 bits (215), Expect = 8e-17
Identities = 93/423 (21%), Positives = 212/423 (50%), Gaps = 41/423 (9%)
Query: 349 KMQEEEPQKKLPVTFEDKRKA--NYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
K + E Q+KL + +K + N + +LE+ + L + Q + + +++EE
Sbjct: 186 KKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE 245
Query: 407 KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRL-EWERI 465
+++++++QE K + E+ E++ ++ Q E+ RR++ RE K+ E+++ L E +++
Sbjct: 246 QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKL 305
Query: 466 RRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEV 525
R QE ++ +EQEE ++ +++ + + E + + +++ + + +R ++Q + + E
Sbjct: 306 REQE---EQMQEQEE--KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 360
Query: 526 LDKQCD--LEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNM-QFSNTPDSGVSLLH 582
+ +Q + E E + Q+++ E + K+ E++ + ER K M + T +
Sbjct: 361 MWEQDERLREKEERMREQEKMWEQEEKM----QEEERIREREKKMREEEETMREQEEKMQ 416
Query: 583 K------KSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSL 636
K + EKE QRL EQ + L ++ + E + + K + ++ Q
Sbjct: 417 KQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ----- 471
Query: 637 LSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKA 696
+ +E Q E+ + + K+ + E + E ++ + ++E R+
Sbjct: 472 -----EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQ 526
Query: 697 KQGKENLWKENLRKEEEEKQKRLQEEKT---QEKIQEEE--RKAEEKQRKDKDTLKAEEK 751
K+ +W++ K EEK+ + QE+KT +EK++EEE R+ E+K R++++ ++ +E+
Sbjct: 527 KK----MWQQE-EKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 581
Query: 752 KRE 754
K +
Sbjct: 582 KMQ 584
Score = 84.7 bits (208), Expect = 5e-16
Identities = 89/405 (21%), Positives = 192/405 (47%), Gaps = 41/405 (10%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEE-WERKQR 409
++EE ++ +E + K E E EK+ + E+ RE E K QK++E WE++++
Sbjct: 370 EKEERMREQEKMWEQEEKMQEEERIREREKKMRE-EEETMREQEEKMQKQEENMWEQEEK 428
Query: 410 ELQEQEWKKQLELEKRLEKQRELERQ--REEERRKDIERREAAKQELERQRRLE------ 461
E Q+Q +Q E EK +E E + +EE+ +D E ++++ RQ ++
Sbjct: 429 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 488
Query: 462 WE-----RIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKK 516
WE R + Q++ +Q+ R E+ RL K++ + + +++ + + +R +K
Sbjct: 489 WEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMR--------EQKKMWQQEEKMREEK 540
Query: 517 QTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDS 576
+TQ+ E + D++ E + ++ ++E + K+ E++++ E+ + MQ +
Sbjct: 541 KTQEQEKKTWDQE------EKMREEERMREREKKMR---EEEEMMREQEEKMQ---EQEE 588
Query: 577 GVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSL 636
+ +K E+EE Q +E++ E++ + E + ++ + + +
Sbjct: 589 KMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKM 648
Query: 637 LSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAA--- 693
+ +++RE Q E+ + + +K++ E K E +K + ++E
Sbjct: 649 WEQEEKMREQEEKMREQEEKMQ-GQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQ 707
Query: 694 -RKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEE 737
K +E +W + +E+EE+ R Q+EK QE++ E E + E
Sbjct: 708 EEKMWGQEEKMWGQEEMREKEERI-RDQKEKMQERLPEHEERCSE 751
Score = 83.6 bits (205), Expect = 1e-15
Identities = 99/422 (23%), Positives = 198/422 (46%), Gaps = 47/422 (11%)
Query: 372 ERGNMELEKRRQALMEQQ--QREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQ 429
ER + LE R + ++ ++ AE + + E E+ + +L +E K++LE K L Q
Sbjct: 167 ERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQ 226
Query: 430 RELERQREEERRKDIERREAAKQELERQRRLEW---ERIRRQELLNQKNREQEEIVRLNS 486
+ +EE R++ E RE K+ + +Q W ER+R QE K REQEE +R
Sbjct: 227 VQTNTLQEEMWRQEEELREQEKK-IRKQEEKMWRQEERLREQE---GKMREQEEKMRRQE 282
Query: 487 KKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQE 546
K+ L + +++ + +++R +K+ ++ E ++ +++ + E K +QE +
Sbjct: 283 KR---------LREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKM 333
Query: 547 YQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKET 606
++ + EKQ+ + Q + + ++ EKEE R++EQ E+E
Sbjct: 334 WRQEERLWEQEKQMREQE----QKMRDQEERMWEQDERLREKEE---RMREQEKMWEQE- 385
Query: 607 ASKLSEMDSF-NNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLY 665
K+ E + + K ++++ + + N++ E E QQ EQ
Sbjct: 386 -EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMW----EQEEKEWQQQRLPEQKE 440
Query: 666 KI-KRDKLKEIERKRLELMQKKKLEDE-----------AARKAKQGKENLWKENLRKEEE 713
K+ +++K++E E K E Q++K+ D+ K ++ ++ +W++ + ++
Sbjct: 441 KLWEQEKMQEQEEKIWE--QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 498
Query: 714 EKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNH 773
E++ QEE+ E+ E R+ EE+ R+ K + EEK RE + + E +
Sbjct: 499 EQKMWDQEERMWEQ-DERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMR 557
Query: 774 DE 775
+E
Sbjct: 558 EE 559
Score = 72.4 bits (176), Expect = 3e-12
Identities = 52/218 (23%), Positives = 117/218 (53%), Gaps = 11/218 (5%)
Query: 348 QKMQEEEP-QKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
+KM+EE+ Q++ T++ + K E E EK+ + E+ RE E K Q+++E+
Sbjct: 534 EKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMRE-EEEMMREQEEKMQEQEEKMRE 592
Query: 407 KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQE-LERQRRLEWERI 465
++ ++ EQE K Q + EK E++ ++ Q EE++ ++ E ++E ++ Q WE+
Sbjct: 593 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQE 652
Query: 466 RRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEV 525
+ +K REQEE ++ +++ + + E + G+ +++ R Q+ +++ Q +K +
Sbjct: 653 EKMREQEEKMREQEE--KMQGQEEKMREQEEKMQGQEEKM--REQEEKMRGQEEKMWGQE 708
Query: 526 LDKQCDLEIM----EIKQLQQELQEYQNKLIYLVPEKQ 559
E M E+++ ++ +++ + K+ +PE +
Sbjct: 709 EKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHE 746
Score = 72.0 bits (175), Expect = 3e-12
Identities = 94/418 (22%), Positives = 191/418 (45%), Gaps = 42/418 (10%)
Query: 364 EDKRKANYE-----RGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKK 418
ED++KA+++ R +E + ++ Q+ E E ++ R+ ++ +
Sbjct: 70 EDEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDA----ARKFEDGNLGE 125
Query: 419 QLELEKRL--------EKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQEL 470
+L RL E QR L ++ D E K+ L I +EL
Sbjct: 126 SKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEEL 185
Query: 471 LNQKNREQEEIVRL-NSKKKNLHLELEALNGKHQQISGRLQDVR---LKKQTQKTELEVL 526
+KN E +E +RL S+K + L ++ L K ++ L V+ L+++ + E E+
Sbjct: 186 -KKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELR 244
Query: 527 DKQCDLEIMEIKQLQQE--LQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKK 584
+++ + E K +QE L+E + K+ + + +R++ + KK
Sbjct: 245 EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKK 304
Query: 585 SLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLF 644
E+EE Q +E++ E+E + E + + + + + + + ++
Sbjct: 305 LREQEEQMQEQEEKM--WEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 362
Query: 645 ---LLLKELRETYNTQQLALEQLYKI-KRDKLKEIERKRLELMQKKKLEDEAARKAKQGK 700
L+E E Q+ EQ K+ + ++++E E+K E + + ++E K ++ +
Sbjct: 363 EQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEE---KMQKQE 419
Query: 701 ENLWKENLRKEEEEKQKRLQEEK----TQEKIQEEERKAEEKQRK--DKDTLKAEEKK 752
EN+W++ +E+E +Q+RL E+K QEK+QE+E K E++ K D++ + +EKK
Sbjct: 420 ENMWEQ---EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKK 474
Score = 62.8 bits (151), Expect = 2e-09
Identities = 53/221 (23%), Positives = 117/221 (52%), Gaps = 31/221 (14%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
+KM+EEE + ++++ E E E++ E+ Q + E+ ++E++ WE++
Sbjct: 567 KKMREEEEMMRE----QEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 622
Query: 408 QRE-LQEQE---WKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWE 463
+ + +QEQE W+++ +++++ EK E E + E+ K E+ E + + E+ R E E
Sbjct: 623 EEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQE-E 681
Query: 464 RIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTEL 523
+++ QE +K REQEE +R +K + G+ +++ G+ + + +++ ++ E
Sbjct: 682 KMQGQE---EKMREQEEKMRGQEEK---------MWGQEEKMWGQEEKMWGQEEMREKEE 729
Query: 524 EVLDKQCDLEIMEIKQLQQELQEYQNKLI--YLVPEKQLLN 562
+ D++ +++Q+ L E++ + L P K L N
Sbjct: 730 RIRDQK--------EKMQERLPEHEERCSEPCLPPSKVLCN 762
Score = 62.0 bits (149), Expect = 3e-09
Identities = 48/226 (21%), Positives = 115/226 (50%), Gaps = 14/226 (6%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
+KM+E+E Q +E + K + M ++ R +++ RE E + +++K+ W+++
Sbjct: 479 EKMREQEDQM-----WEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQE 533
Query: 408 QRELQEQEWKKQLELEKRL----EKQRELERQREEERRKDIERREAAKQELERQRRLEWE 463
++ +E KK E EK+ EK RE ER RE E++ E +QE + Q + E
Sbjct: 534 EKMREE---KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 590
Query: 464 RIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTEL 523
R + +++ Q+ + QE+ ++ +++ + + E K Q+ + + K Q Q+ ++
Sbjct: 591 REQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEE--EDKMQEQEEMMWEQEEKMQEQEEKM 648
Query: 524 EVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQ 569
+++ + ++++ ++++Q + K+ + Q E+++ +
Sbjct: 649 WEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQE 694
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 101 bits (252), Expect = 4e-21
Identities = 107/485 (22%), Positives = 229/485 (47%), Gaps = 42/485 (8%)
Query: 297 LKAEEFILAMHLTDMAKAGQPLPLTLPPE-LVPPSFRGGKQIDSINGTLPSYQKMQEEEP 355
+++E+ + +++ ++ + + L LP + L + GK++ S++ L + +++E E
Sbjct: 233 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA--QVEENEL 290
Query: 356 QKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQE 415
+L E+K E+ EK Q+Q E R+ +++ E E K R +E
Sbjct: 291 WNRLNQQQEEKMWRQEEKIQEWEEKI------QEQEEKIREQEEKIREQEEKMRRQEEMM 344
Query: 416 WKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKN 475
W+K E+++ +Q E+ ++EE+ R+ E ++++ RQ + WE+ + L +K
Sbjct: 345 WEK----EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 400
Query: 476 REQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKT---------ELEVL 526
EQE+I K++ E + Q+ Q+ ++++Q +K + E +
Sbjct: 401 HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKI 460
Query: 527 DKQCDLEIMEIKQLQQELQEYQNKL-----IYLVPEKQLLNERIKNMQFSNT--PDSGVS 579
+Q + E +Q Q+E+ + K+ I+ EK E Q + +
Sbjct: 461 HEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIR 520
Query: 580 LLHKKSLEKEELCQRLKEQLDALEK--ETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLL 637
+K E+EE R +E++ E+ K+ E + + K +D + + +
Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIR 580
Query: 638 SCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAK 697
++ +++RE +Q E+++K + +K++E E K E +K + ++E R+ +
Sbjct: 581 EQEEKVWRQEEKIREQEEKRQEQEEKMWK-QEEKIREQEEKIQEQEEKIREQEEKIREQE 639
Query: 698 ---QGKENLWKENLRKEEEEKQKRLQEEKT----QEKIQEEERK---AEEKQRKDKDTLK 747
Q +E E K E+++K ++E+T +EKI+E+E+K EEK R+ ++ ++
Sbjct: 640 EMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQ 699
Query: 748 AEEKK 752
+E+K
Sbjct: 700 EQEEK 704
Score = 90.1 bits (222), Expect = 1e-17
Identities = 98/420 (23%), Positives = 207/420 (49%), Gaps = 34/420 (8%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRE 410
+EE+ +++ + +E + K + M ++ + E+ E E K +E EE +Q +
Sbjct: 347 KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI-RELEEKMHEQEK 405
Query: 411 LQEQEWKKQ-----LELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRL-EWER 464
++EQE K+Q E EKR E++ ++ RQ E+ R ++ + RE K+ ++ ++ E E+
Sbjct: 406 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEK 465
Query: 465 IRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKT--- 521
IR +E K +EQEE+ R K +H + E K + Q+ +++KQ +K
Sbjct: 466 IREEE----KRQEQEEMWRQEEK---IHEQEEIWRQKEKMHE---QEEKIRKQEEKVWRQ 515
Query: 522 ELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLL 581
E ++ +++ + E K +QE + + + ++ EK E+I + + +
Sbjct: 516 EEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQ 575
Query: 582 HKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLN 641
+K E+EE R +E++ E+E + E + + K ++ + + +
Sbjct: 576 EEKIREQEEKVWRQEEKIR--EQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEE 633
Query: 642 NLFLLLKELRETYNTQQLAL-EQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGK 700
+ +E E Q+ + EQ K+ + K E++ Q++K+ ++ + +Q +
Sbjct: 634 KI----REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEE 689
Query: 701 ENLWKENLRKEEEEK----QKRL--QEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRE 754
+ +E + +E+EEK ++++ QEEK QE+ +E+ R+ EEK + + L+ +E+K +
Sbjct: 690 KIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ-EEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Score = 87.4 bits (215), Expect = 8e-17
Identities = 107/476 (22%), Positives = 222/476 (46%), Gaps = 71/476 (14%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEK---RRQALMEQQQREAERKAQKEKEEW 404
++++E+ + + + + K+ + EL++ R + L+ QQQ +AE A +E
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAE--ADHLGKEL 274
Query: 405 ERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWER 464
+ +LQ Q ++ EL RL +Q+E + R+EE+ I+ E QE E + R + E+
Sbjct: 275 QSVSAKLQAQV--EENELWNRLNQQQEEKMWRQEEK---IQEWEEKIQEQEEKIREQEEK 329
Query: 465 IRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELE 524
IR QE +K R QEE++ K++ + + E + K +++ R +++ +K+ + E
Sbjct: 330 IREQE---EKMRRQEEMMW--EKEEKMRRQEEMMWEKEEKMR-RQEEMMWEKEEKMRRQE 383
Query: 525 VLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKK 584
+ + + +I E+++ E ++ + + EK+ E+I+ + ++ + +K
Sbjct: 384 EMMWEKEEKIRELEEKMHEQEKIREQ-----EEKRQEEEKIREQEKRQEQEAKMWRQEEK 438
Query: 585 SLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLF 644
E+EE +++EQ + ++ K+ E + + K ++ Q
Sbjct: 439 IREQEE---KIREQEKKMWRQE-EKIHEQEKIREEEKRQEQEEMWRQ------------E 482
Query: 645 LLLKELRETYNTQQLALEQLYKIKR---------DKLKEIERKRLELMQKKKLEDEAARK 695
+ E E + ++ EQ KI++ +K++E E K E +K ++E R+
Sbjct: 483 EKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIRE 542
Query: 696 AKQ---------GKENLWKENLRKEEEEKQKRLQEE---------KTQEKIQEEERKAEE 737
++ +E +W+E R+E+E+K R +E+ + +EKI+E+E K +E
Sbjct: 543 QEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQE 602
Query: 738 KQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGE 793
++ K K EEK RE + + R +E ++ Q E+ +GE
Sbjct: 603 QEEK---MWKQEEKIREQEEKIQEQEE----KIREQEEKIREQEEMTQEQEEKMGE 651
Score = 79.7 bits (195), Expect = 2e-14
Identities = 88/406 (21%), Positives = 186/406 (45%), Gaps = 61/406 (15%)
Query: 335 KQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAE 394
++I + + +K++E+E +++ ++ K + M ++ + E++ RE E
Sbjct: 391 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 450
Query: 395 RKAQKEKE---EWERKQRELQEQEWKKQLELEKRLEKQRELERQREE--ERRKDIERREA 449
+K +++E E E+ + E + QE ++ E+++ +Q E+ RQ+E+ E+ + I ++E
Sbjct: 451 KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEE 510
Query: 450 AKQELERQRRLEWERIRRQE----LLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQI 505
E + R + E+IR QE +K REQEE+ R K E + Q+
Sbjct: 511 KVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQED 570
Query: 506 SGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERI 565
Q+ ++++Q +K + + +I E ++ +QE +E K +++ + E+
Sbjct: 571 KMWRQEEKIREQEEKVWRQ------EEKIREQEEKRQEQEEKMWK------QEEKIREQE 618
Query: 566 KNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEK---ETASKLSEMDS--FNNQL 620
+ +Q + + +K E+EE+ Q +E++ E+ E K+ E + + +
Sbjct: 619 EKIQ---EQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEE 675
Query: 621 KCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRL 680
K + + +E E Q E++ + + +K+ E E K
Sbjct: 676 KIREQEKKI------------------REQEEKIREQ----EEMMQEQEEKMWEQEEKMC 713
Query: 681 ELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQE 726
E +K + ++E K ++ +E +W E+E + R QEEK QE
Sbjct: 714 EQEEKMQEQEE---KMRRQEEKMW-------EQEVRLRQQEEKMQE 749
Score = 70.9 bits (172), Expect = 7e-12
Identities = 94/417 (22%), Positives = 184/417 (44%), Gaps = 50/417 (11%)
Query: 364 EDKRKANYE-----RGNMELEKRRQALMEQQQREAERK---AQKEKEEWERKQRELQEQ- 414
ED++KA+++ R +E + ++ Q+ E + +Q ++ E + R+L +
Sbjct: 108 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 167
Query: 415 --EWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQ----RRLEWERIRRQ 468
WK ELE+ L +++ + + + R+A EL R L+ + + Q
Sbjct: 168 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 227
Query: 469 ELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGR-------LQDVRLKKQTQKT 521
E L E+ EI +LN K+ LE L QQ+ LQ V K Q Q
Sbjct: 228 EKLQLVESEKSEI-QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 286
Query: 522 ELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLL 581
E E+ ++ + ++ + ++++QE++ K+ + + E+I+ + +
Sbjct: 287 ENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE------EKMRRQ 340
Query: 582 HKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLN 641
+ EKEE +R +E + EKE + E + + K ++ + + +
Sbjct: 341 EEMMWEKEEKMRRQEEMM--WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI----- 393
Query: 642 NLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAAR----KAK 697
+EL E + Q+ EQ K + ++ + KR E K ++E R K +
Sbjct: 394 ------RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 447
Query: 698 QGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRE 754
+ ++ +W++ + E+EK + +EEK QE QEE + EEK + ++ + +EK E
Sbjct: 448 EQEKKMWRQEEKIHEQEKIR--EEEKRQE--QEEMWRQEEKIHEQEEIWRQKEKMHE 500
Score = 52.8 bits (125), Expect = 2e-06
Identities = 41/158 (25%), Positives = 80/158 (50%), Gaps = 19/158 (12%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKE-------- 402
QEE+ Q++ ++ + K + ++ ++ + E++ RE E Q+++E
Sbjct: 596 QEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEK 655
Query: 403 --EWERKQRELQEQEWKKQ---LELEKRLEKQRELERQREE---ERRKDIERREAAKQEL 454
E E K +E +E W+++ E EK++ +Q E R++EE E+ + + +E E
Sbjct: 656 MCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 715
Query: 455 ERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLH 492
E + + + E++RRQE +K EQE +R +K H
Sbjct: 716 EEKMQEQEEKMRRQE---EKMWEQEVRLRQQEEKMQEH 750
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 97.8 bits (242), Expect = 6e-20
Identities = 70/264 (26%), Positives = 123/264 (46%), Gaps = 61/264 (23%)
Query: 987 IALYPYSSVEPGDLTFTEGEEILVTQKDGEWW-TGSIGDRSGIFPSNYVKPKDQESFGSA 1045
+A + Y + + +L + E + + WW + +++G PSNYV+ K+ S
Sbjct: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASI 67
Query: 1046 SKS-------GASNKKPEI------------------------AQVTSAYVASGSEQLSL 1074
K+ G +KP + A V Y+A ++LSL
Sbjct: 68 VKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSL 127
Query: 1075 APGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPS---------SERATPA 1125
G +++++K + GWW+G Q GWFP+++V G S SE+
Sbjct: 128 IKGTKVIVMEKCSDGWWRGSYNG-----QVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAV 182
Query: 1126 FH-----PVCQVI-AMYDYAANNEDELSFSKGQLINVMNK--DDPDWWQ-GEINGVTGLF 1176
+ V V+ A+Y ++++N++EL+F KG +++V+ K +DP+WW+ +ING+ GL
Sbjct: 183 VNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLV 242
Query: 1177 PSNYV------KMTTDSDPSQQWC 1194
P NYV +T+ +PS C
Sbjct: 243 PKNYVTVMQNNPLTSGLEPSPPQC 266
Score = 65.9 bits (159), Expect = 2e-10
Identities = 46/143 (32%), Positives = 69/143 (48%), Gaps = 11/143 (7%)
Query: 900 NLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVK---IIP 955
N+ A ++ A++++ L+ K + V+E+ + WW G +G GWFP +YV P
Sbjct: 108 NMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSP 167
Query: 956 GSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-- 1013
+ E L A VN T V + ALYP+SS +L F +G+ + V +K
Sbjct: 168 LGDHVGSLSEKLAAVVNNLNTGQVLHVVQ---ALYPFSSSNDEELNFEKGDVMDVIEKPE 224
Query: 1014 -DGEWW-TGSIGDRSGIFPSNYV 1034
D EWW I G+ P NYV
Sbjct: 225 NDPEWWKCRKINGMVGLVPKNYV 247
Score = 57.8 bits (138), Expect = 6e-08
Identities = 49/193 (25%), Positives = 74/193 (38%), Gaps = 61/193 (31%)
Query: 766 YPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAV 825
+ + A DE+S G + V EK GW GS+ G GWFP NYV
Sbjct: 115 FNYMAEREDELSLIKGTKVIVMEKC--SDGWWRGSYNGQVGWFPSNYV------------ 160
Query: 826 SPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSP 885
T PL + V + +K +A ++
Sbjct: 161 ---------------TEEGDSPLGDH-----------------VGSLSEKLAAVVNNLNT 188
Query: 886 GSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN---WW-FGEVHG 941
G V + QAL +++ D LNF K D++ V+E+ EN WW +++G
Sbjct: 189 GQVLHV-----------VQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKING 237
Query: 942 GRGWFPKSYVKII 954
G PK+YV ++
Sbjct: 238 MVGLVPKNYVTVM 250
Score = 48.9 bits (115), Expect = 3e-05
Identities = 28/85 (32%), Positives = 40/85 (47%), Gaps = 1/85 (1%)
Query: 744 DTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEP-GWLYGSFQ 802
+ L A T VL +ALYPF + N +E++F GD++ V EK +P W
Sbjct: 177 EKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKIN 236
Query: 803 GNFGWFPCNYVEKMPSSENEKAVSP 827
G G P NYV M ++ + P
Sbjct: 237 GMVGLVPKNYVTVMQNNPLTSGLEP 261
Score = 38.1 bits (87), Expect = 0.053
Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEIN-GVTGLFPSNYVK 1182
V+A +DY A E EL K + + +++ D WW+ + TG PSNYV+
Sbjct: 7 VVAKFDYVAQQEQELDIKKNERLWLLD-DSKSWWRVRNSMNKTGFVPSNYVE 57
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 97.1 bits (240), Expect = 1e-19
Identities = 100/472 (21%), Positives = 223/472 (47%), Gaps = 39/472 (8%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRE 410
QE++ +K+ + + + + G M ++ + E++ RE E++ +++++E R+Q+E
Sbjct: 284 QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL-REQKE 342
Query: 411 LQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE------WER 464
L+EQE + Q + EK E++ ++ Q E+ R++ E KQ E+++++ WE+
Sbjct: 343 LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQ 402
Query: 465 IRRQELLNQKNREQE----EIVRLNSKKKNLHLELEALNGKH-----QQISGRLQDVRLK 515
R ++ REQE ++ ++ +KK E + + + ++I R + +R +
Sbjct: 403 DERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE 462
Query: 516 KQTQKTELEVLDKQCD-LEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTP 574
++T + + E + KQ + + E K+ QQ+ Q + ++ + Q E+I +
Sbjct: 463 EETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 522
Query: 575 DSGVSLLHKKSLEKEELCQRLKEQLDAL-EKETASKLSEMDSFNNQLKCGNMDDSVLQCL 633
+ KK +E +++EQ D + E+E + E ++ + + +
Sbjct: 523 QEEMWGQEKKMWRQE----KMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKT 578
Query: 634 LSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKR--DKLKEIERKRLELMQKKKLEDE 691
+ + + ++ +++ EQ K++ +K++E E K E +K + ++E
Sbjct: 579 WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEE 638
Query: 692 AA----RKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLK 747
K + +E +W++ E++EK ++ + QEK+QE+E K E+++ +K T +
Sbjct: 639 KMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQE 698
Query: 748 AE------EKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGE 793
E EK RE S+ + + R +EM + +Q E+ + E
Sbjct: 699 QEKKTWDQEKMREEESMREREKKM-----REEEEMMREQEEKMQEQEEKMQE 745
Score = 96.7 bits (239), Expect = 1e-19
Identities = 88/430 (20%), Positives = 210/430 (48%), Gaps = 35/430 (8%)
Query: 343 TLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKE 402
TL QEEE + E ++K + M ++ R E + RE E K ++++
Sbjct: 269 TLQEEMWRQEEELR-------EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEK 321
Query: 403 EWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEW 462
+++EL+EQE K+L +K L +Q E +++EE+ + E+ ++++ RQ W
Sbjct: 322 RLREQEKELREQE--KELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 379
Query: 463 ERIRRQELLNQKNREQEEIV-----RLNSKKKNLHLE---LEALNGKHQQISGRLQDVRL 514
E+ ++ QK R+QEE + RL K++ + + E + ++ + Q+ +
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT 439
Query: 515 KKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTP 574
+ Q +K + E ++ + ++ E ++ +E +E K E+ + + K Q P
Sbjct: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQK-----QEENMWEQEEKEWQQQRLP 494
Query: 575 DSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLL 634
+ L ++ ++++E +++ EQ + + ++ + Q K +D + +
Sbjct: 495 EQKEKLWEQEKMQEQE--EKIWEQEEKI-RDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551
Query: 635 SLLSCLNNLFLLLKEL-RETYNTQQLALEQLYKIK-RDKLKEIERKRLE----LMQKKKL 688
+ ++ + + ++T ++ +Q K++ ++++E E+K E + ++++
Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611
Query: 689 EDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEK---TQEKIQEEERKAEEKQRK-DKD 744
E K ++ +E +W++ + +E+E++ QEEK +EK+ E++R E+K++ + +
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 671
Query: 745 TLKAEEKKRE 754
++ +EK +E
Sbjct: 672 KMQEQEKMQE 681
Score = 95.5 bits (236), Expect = 3e-19
Identities = 100/467 (21%), Positives = 222/467 (47%), Gaps = 89/467 (19%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWE----- 405
QEE+ ++ +E +++ + M ++ R +++ RE E + +++++ WE
Sbjct: 367 QEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKM 426
Query: 406 RKQRELQEQEWKKQLELEKRLEKQRELER------------------QREEERRKDIERR 447
R+++++QEQE K + + EK E++R ER Q++EE + E +
Sbjct: 427 REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK 486
Query: 448 EAAKQELERQRRLEWERIRRQEL------LNQKNREQEEI----------VRLNSKKKNL 491
E +Q L Q+ WE+ + QE +K R+QEE+ ++ ++ +
Sbjct: 487 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 546
Query: 492 HLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKL 551
+ E + + Q++ Q+ R++K+TQ+ E + D++ E + ++ ++E + K+
Sbjct: 547 WEQEEKMRDQEQKMWD--QEERMEKKTQEQEKKTWDQE------EKMREEERMREREKKM 598
Query: 552 IYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEK------- 604
E++++ E+ + MQ + + +K E+EE Q +E++ E+
Sbjct: 599 R---EEEEMMREQEEKMQ---EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEE 652
Query: 605 ---------ETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYN 655
E KL E + Q K ++ + + ++ ++T++
Sbjct: 653 KMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQ-------EQEKKTWD 705
Query: 656 TQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRK-EEEE 714
+++ E+ + + K++E E E +K + ++E K ++ +E +W++ + E+EE
Sbjct: 706 QEKMREEESMREREKKMREEEEMMREQEEKMQEQEE---KMQEQEEEMWEQEEKMWEQEE 762
Query: 715 K---QKRLQEEKTQ----EKIQEEER--KAEEKQRKDKDTLKAEEKK 752
K Q+RL E+K + EK+QE+E+ + EEK R ++ ++ +E+K
Sbjct: 763 KMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEK 809
Score = 91.7 bits (226), Expect = 4e-18
Identities = 97/437 (22%), Positives = 208/437 (47%), Gaps = 81/437 (18%)
Query: 349 KMQEEEPQKKLPVTFEDKRKA--NYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
K + E Q+KLP+ +K + N + +LE+ + L + Q + + +++EE
Sbjct: 224 KKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE 283
Query: 407 KQRELQEQE---WKKQLEL-----------------EKRLEKQRELERQREEERRKDIER 446
+++++++QE W+++ L EKRL +Q + R++E+E R+ E
Sbjct: 284 QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKEL 343
Query: 447 REAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS 506
RE +Q E++ ++ WE+ + +K QEE RL ++K + + + + + +++
Sbjct: 344 REQEEQMQEQEEKM-WEQEEKMREQEEKMWRQEE--RLWEQEKQMREQEQKMRDQEERMW 400
Query: 507 GRLQDVRLK-KQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERI 565
QD RL+ K+ + E E + +Q + ++ E K++Q++ ++ +++ EK ERI
Sbjct: 401 E--QDERLREKEERMREQEKMWEQVE-KMREEKKMQEQEKKTRDQ-----EEKMQEEERI 452
Query: 566 KNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNM 625
+ + KK E+EE ++EQ + ++K+ + + + Q +
Sbjct: 453 RERE-------------KKMREEEE---TMREQEEKMQKQEENMWEQEEKEWQQQR---- 492
Query: 626 DDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQK 685
L E +E Q+ EQ KI + K +++ + +K
Sbjct: 493 ---------------------LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEK 531
Query: 686 KKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKA---EEKQRKD 742
K E K ++ ++ +W++ + ++E++ QEE+ ++K QE+E+K EEK R++
Sbjct: 532 KMWRQE---KMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREE 588
Query: 743 KDTLKAEEKKRETASVL 759
+ + E+K RE ++
Sbjct: 589 ERMREREKKMREEEEMM 605
Score = 88.2 bits (217), Expect = 4e-17
Identities = 100/462 (21%), Positives = 215/462 (46%), Gaps = 59/462 (12%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEE-WER 406
+KM+EE+ ++ D+ + E + +++ E+ RE E K QK++E WE+
Sbjct: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 483
Query: 407 KQRELQEQEWKKQLELEKRLEKQRELERQ--REEERRKDIERREAAKQELERQRRLE--- 461
+++E Q+Q +Q E EK +E E + +EE+ +D E ++++ RQ ++
Sbjct: 484 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 543
Query: 462 ---WERIRRQELLNQKNREQEEIVRLNSKKKNLHL-ELEALNGKHQQISGRLQDVRLKKQ 517
WE+ + QK +QEE + ++++ + E + +++ R + +R +++
Sbjct: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 603
Query: 518 TQKTELEVLDKQCD-LEIMEIKQLQQE--LQEYQNKLIYLVPEKQLLNERIKNMQFSNTP 574
+ + E + +Q + ++ E K +QE +QE + K+ E+++ + K + P
Sbjct: 604 MMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKM--WEQEEKMWEQEEKMWEQQRLP 661
Query: 575 DSGVSLLHKKSLEKEELCQRLKEQL---DALEKETAS---------KLSEMDSFNNQLKC 622
+ L + ++++E Q +E++ + +EK+T K+ E +S + K
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKK 721
Query: 623 GNMDDSVLQCLLSLLSCLNNLFL-----------LLKELRETYNTQQLALEQLYKI---- 667
++ +++ + + E E QQ EQ K+
Sbjct: 722 MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 781
Query: 668 ---KRDKLKEIERKRLELMQKKKLEDEAAR----KAKQGKENLW--KENLRKEEE----- 713
+++K+ E E K + +K + ++E R K + +E +W +E + +EE
Sbjct: 782 KMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ 841
Query: 714 EKQKRLQEEKTQEKIQEEE---RKAEEKQRKDKDTLKAEEKK 752
E++ QEEK +EK+Q +E R+ EEK R ++ ++ +E+K
Sbjct: 842 EEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEK 883
Score = 70.1 bits (170), Expect = 1e-11
Identities = 80/359 (22%), Positives = 160/359 (44%), Gaps = 39/359 (10%)
Query: 427 EKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNS 486
E QR L ++ D E K+ L I +EL + QE++ S
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239
Query: 487 KKKNLHLELEALNGKHQQISGRLQDVR---LKKQTQKTELEVLDKQCDLEIMEIKQLQQE 543
+K + L ++ L K ++ L V+ L+++ + E E+ +++ + E K +QE
Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE 299
Query: 544 --LQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDA 601
L+E + K+ EK E+ Q + L +K L ++E ++++EQ +
Sbjct: 300 ERLREQEGKM-REQEEKMWRQEKRLREQEKELREQEKELREQKELREQE--EQMQEQEEK 356
Query: 602 L-EKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLF---LLLKELRETYNTQ 657
+ E+E + E + + + + + + + ++ L+E E Q
Sbjct: 357 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQ 416
Query: 658 QLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAAR------------------KAKQG 699
+ EQ+ K++ +K + + K+ ++K E+E R K ++
Sbjct: 417 EKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ 476
Query: 700 KENLWKENLRKEEEEKQKRLQEEK----TQEKIQEEERKAEEKQRK--DKDTLKAEEKK 752
+EN+W++ +E+E +Q+RL E+K QEK+QE+E K E++ K D++ + +EKK
Sbjct: 477 EENMWEQ---EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKK 532
Score = 65.1 bits (157), Expect = 4e-10
Identities = 58/233 (24%), Positives = 124/233 (53%), Gaps = 32/233 (13%)
Query: 347 YQKMQEEE----------PQKKLPVTFEDKRKANYERGNMELE---KRRQALM---EQQQ 390
++KMQE+E Q+K+ +++ K +++ M E + R+ M E+
Sbjct: 670 HEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMM 729
Query: 391 REAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQRE--------EERRK 442
RE E K Q+++E+ + ++ E+ EQE +K E E+++ +Q+ L Q+E +E+ K
Sbjct: 730 REQEEKMQEQEEKMQEQEEEMWEQE-EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 788
Query: 443 DIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKH 502
E+ E + + E+ R E E++R QE +K R QEE ++ +++ + + E + G+
Sbjct: 789 IWEQEEKMRDQEEKMRGQE-EKMRGQE---EKMRGQEE--KMWGQEEKMWGQEEKMWGQE 842
Query: 503 QQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLV 555
+++ G+ + + K Q Q+ ++ +++ + ++++ Q+E Q + IY V
Sbjct: 843 EKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMRE-QEEKMRGQEEKIYCV 894
Score = 52.8 bits (125), Expect = 2e-06
Identities = 55/193 (28%), Positives = 97/193 (50%), Gaps = 26/193 (13%)
Query: 576 SGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLS 635
S VS HKK+ + + L ++ DAL E L N +LK N + LQ L
Sbjct: 186 SAVSTRHKKA---DRYIEELTKERDALSLE----LYRNTITNEELKKKNAE---LQEKLP 235
Query: 636 LL-SCLNNLFLLLKELRETYNTQQLALEQLYKI--------KRDKLKEIERKRLELMQKK 686
L S + + L +KEL+ + L Q+ + ++L+E E+K + +K
Sbjct: 236 LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295
Query: 687 KLEDEAAR----KAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKD 742
++E R K ++ +E +W++ R E+EK+ R QE++ +E Q+E R+ EE+ ++
Sbjct: 296 WRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELRE--QKELREQEEQMQEQ 353
Query: 743 KDTL-KAEEKKRE 754
++ + + EEK RE
Sbjct: 354 EEKMWEQEEKMRE 366
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 92.8 bits (229), Expect = 2e-18
Identities = 109/488 (22%), Positives = 233/488 (47%), Gaps = 92/488 (18%)
Query: 297 LKAEEFILAMHLTDMAKAGQPLPLTLPPE-LVPPSFRGGKQIDSINGTLPSYQKMQEEEP 355
+++E+ + +++ ++ + + L LP + L + GK++ S++ L + +++E E
Sbjct: 233 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA--QVEENEL 290
Query: 356 QKKLPVTFEDK---RKANYERGNMELEKRRQALMEQQQ--REAERKAQK------EKEE- 403
+L E+K ++ + +++++ + + EQ++ RE E K ++ EKEE
Sbjct: 291 WNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEK 350
Query: 404 --------WER--KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQE 453
WE+ K R L+E W+K+ ++ + EK E E+ RE+E ++ E + +++
Sbjct: 351 MRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 410
Query: 454 LERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVR 513
+ Q W RQE +K REQEE +R ++K + + E + H+Q R ++ R
Sbjct: 411 RQEQEAKMW----RQE---EKIREQEEKIR--EQEKKMWRQEEKI---HEQEKIREEEKR 458
Query: 514 LKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNT 573
+++ + E + +Q ++ + K +QE Q + ++ EK E
Sbjct: 459 QEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQE---------- 508
Query: 574 PDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCL 633
+K E+EE R +E++ +E K+ E + K ++
Sbjct: 509 ---------EKIREQEEKMWRQEEKI----REQEEKIREQEE-----KIREQEE------ 544
Query: 634 LSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKR--DKLKEIERKRLELMQKKKLEDE 691
+++E E Q+ +++ K++R +K++E E K E QK+K+ ++
Sbjct: 545 ------------MMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIRE--QKEKIREQ 590
Query: 692 AARKAKQGKENLWKENLRKEEEEKQKRLQEE--KTQEKIQEEE---RKAEEKQRKDKDTL 746
+ +Q ++ +E + +E+EEK +E+ + +EK+QE+E R+ EEK + + L
Sbjct: 591 EEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 650
Query: 747 KAEEKKRE 754
+ +E+K +
Sbjct: 651 RQQEEKMQ 658
Score = 84.0 bits (206), Expect = 8e-16
Identities = 96/436 (22%), Positives = 203/436 (46%), Gaps = 71/436 (16%)
Query: 354 EPQKKLPVTFEDKRKANY-------ERGNMELEKRRQALMEQQQREAERKAQKEKE--EW 404
E ++ L K+KA+ ER + LE R + +++ +E K Q++ + E
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVES 235
Query: 405 ERKQRELQEQEWKKQLELEKRLEKQRELERQ-------------------REEERRKDIE 445
E+ + +L +E K++LE K L Q++L+ + E E +
Sbjct: 236 EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLN 295
Query: 446 RREAAKQELERQRRLEW-ERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQ 504
+++ K + ++ EW E+I+ QE +K REQEE +R +K E + + ++
Sbjct: 296 QQQEEKMWRQEEKIQEWEEKIQEQE---EKIREQEEKIREQEEKMR---RQEEMMWEKEE 349
Query: 505 ISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNER 564
R +++ +K+ + LE + + + +I E+++ E ++ + + EK+ E+
Sbjct: 350 KMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQ-----EEKRQEEEK 404
Query: 565 IKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGN 624
I+ + ++ + +K E+EE +++EQ + ++ K+ E + + K
Sbjct: 405 IREQEKRQEQEAKMWRQEEKIREQEE---KIREQEKKMWRQ-EEKIHEQEKIREEEKRQE 460
Query: 625 MDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQ 684
++ Q ++E E + ++ EQ +K+++ E K Q
Sbjct: 461 QEEMWRQ------------EEKIREQEEIWRQKEKMHEQ------EKIRKQEEK--VWRQ 500
Query: 685 KKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEK---IQEEERK---AEEK 738
++K+ D+ K ++ +E +W++ + E+E++ R QEEK +E+ +QE+E K EEK
Sbjct: 501 EEKMHDQ-EEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEK 559
Query: 739 QRKDKDTLKAEEKKRE 754
++ + + EEK RE
Sbjct: 560 MQEQEKMRRQEEKIRE 575
Score = 81.3 bits (199), Expect = 5e-15
Identities = 100/445 (22%), Positives = 205/445 (46%), Gaps = 86/445 (19%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEK---RRQALMEQQQREAER--------- 395
++++E+ + + + + K+ + EL++ R + L+ QQQ +AE
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 276
Query: 396 -----KAQKEKEE-WERKQRELQE---------QEWKKQL-ELEKRLEKQRELERQREEE 439
+AQ E+ E W R ++ +E QEW++++ E E+++ +Q E R++EE+
Sbjct: 277 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEK 336
Query: 440 RRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALN 499
R+ E ++++ RQ + WE+ + L + E+EE +R +K + E E +
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMH---EQEKIR 393
Query: 500 GKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQ 559
+ ++ R ++ ++++Q ++ E E + + +I E Q+E Q K ++ EK
Sbjct: 394 EQEEK---RQEEEKIREQEKRQEQEAKMWRQEEKIRE----QEEKIREQEKKMWRQEEKI 446
Query: 560 LLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQ 619
E+I+ +K E+EE+ R +E++ E+ K + + Q
Sbjct: 447 HEQEKIRE--------------EEKRQEQEEMW-RQEEKIREQEEIWRQK----EKMHEQ 487
Query: 620 LKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKR--DKLKEIER 677
K ++ V ++ + ++ ++ EQ K+ R +K++E E
Sbjct: 488 EKIRKQEEKVW-----------------RQEEKMHDQEEKIREQEEKMWRQEEKIREQEE 530
Query: 678 KRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEK---TQEKIQEEERK 734
K E +K + ++E Q +E E K +E+++ R QEEK +EKI+E++ K
Sbjct: 531 KIREQEEKIREQEEMM----QEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEK 586
Query: 735 AEEKQRKDKDTLKAEEKKRETASVL 759
E++ K + EEK RE ++
Sbjct: 587 IREQEEK---IWEQEEKIREQEEMM 608
Score = 77.4 bits (189), Expect = 8e-14
Identities = 99/438 (22%), Positives = 193/438 (44%), Gaps = 64/438 (14%)
Query: 364 EDKRKANYE-----RGNMELEKRRQALMEQQQREAERK---AQKEKEEWERKQRELQEQ- 414
ED++KA+++ R +E + ++ Q+ E + +Q ++ E + R+L +
Sbjct: 108 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 167
Query: 415 --EWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQ----RRLEWERIRRQ 468
WK ELE+ L +++ + + + R+A EL R L+ + + Q
Sbjct: 168 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 227
Query: 469 ELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGR-------LQDVRLKKQTQKT 521
E L E+ EI +LN K+ LE L QQ+ LQ V K Q Q
Sbjct: 228 EKLQLVESEKSEI-QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 286
Query: 522 ELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLL 581
E E+ ++ + ++ + ++++QE++ K+ Q E+I+ +
Sbjct: 287 ENELWNRLNQQQEEKMWRQEEKIQEWEEKI-------QEQEEKIREQE------------ 327
Query: 582 HKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLN 641
+K E+EE +R +E + EKE + E + + K +++ + + +
Sbjct: 328 -EKIREQEEKMRRQEEMM--WEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKI----- 379
Query: 642 NLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAAR----KAK 697
+EL E + Q+ EQ K + ++ + KR E K ++E R K +
Sbjct: 380 ------RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 433
Query: 698 QGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETAS 757
+ ++ +W++ + E+EK + +EEK QE QEE + EEK R+ ++ + +EK E
Sbjct: 434 EQEKKMWRQEEKIHEQEKIR--EEEKRQE--QEEMWRQEEKIREQEEIWRQKEKMHEQEK 489
Query: 758 VLVNYRALYPFEARNHDE 775
+ ++ E + HD+
Sbjct: 490 IRKQEEKVWRQEEKMHDQ 507
Score = 50.8 bits (120), Expect = 8e-06
Identities = 51/169 (30%), Positives = 86/169 (50%), Gaps = 23/169 (13%)
Query: 348 QKMQEEEP----QKKLPVTFEDKRKANYERGNMELEK-RRQALMEQQQRE---AERKAQK 399
+KM ++E Q++ E+K + E+ + EK R Q M Q+Q E + + +
Sbjct: 502 EKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQ 561
Query: 400 EKEEWERKQRELQEQEWKKQLELEK----------RLEKQRELERQREEERRKDIERREA 449
E+E+ R++ +++EQE K + + EK + EK RE E +E+ K E+ E
Sbjct: 562 EQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEK 621
Query: 450 AKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLE-LEA 497
++ E+ + E E++RRQE +K EQE +R +K H E LEA
Sbjct: 622 MCEQEEKMQEQE-EKMRRQE---EKMWEQEVRLRQQEEKMQEHQEHLEA 666
Score = 45.4 bits (106), Expect = 3e-04
Identities = 37/115 (32%), Positives = 67/115 (58%), Gaps = 17/115 (14%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQA---LMEQQQ--REAERKAQKEKE 402
+KMQE+E ++ E+K + E+ + EK R+ + EQ++ RE E Q+++E
Sbjct: 558 EKMQEQEKMRRQ----EEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEE 613
Query: 403 E-WERKQR------ELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAA 450
+ WE++++ ++QEQE K + + EK E++ L RQ+EE+ ++ E EAA
Sbjct: 614 KMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL-RQQEEKMQEHQEHLEAA 667
>gi|125625326 RALBP1 associated Eps domain containing 2 isoform 1
[Homo sapiens]
Length = 660
Score = 92.4 bits (228), Expect = 2e-18
Identities = 98/343 (28%), Positives = 138/343 (40%), Gaps = 40/343 (11%)
Query: 47 NFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQP 106
+ F S LPA L +I L + G +F IA+KLI G LPV + I +
Sbjct: 77 DLFRASQLPAETLHQITELCGAKRVGYFGPTQFYIALKLIAAAQSG--LPVRIESIKCEL 134
Query: 107 PMFSPLISA-----RFGMGS--------MPNLSIPQPLPPAAPITSLSSATSGTNLPPLM 153
P+ ++S RFG + +P L+ + T + PL
Sbjct: 135 PLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQQETQSPTMSPLA 194
Query: 154 MPTPLVPSVSTSSLPNGTASLI----QPLPIPYSSS---TLPHGSSYSLMMGGFGGASIQ 206
P P L +G + L Q P PY + P GSS GG G ++
Sbjct: 195 SPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSS----SGGPGTKPLR 250
Query: 207 KAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGF 266
SLI S S L NS W + + R Y +F +L S ++SG
Sbjct: 251 HQASLI-----RSFSVERELQDNSSYPD-EPWRITEEQREYYVNQFRSLQPDPSSFISGS 304
Query: 267 QARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPEL 326
A+N +S LS +L+ IW L+D D DG L EF A HL K G PLP LPP L
Sbjct: 305 VAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTL 364
Query: 327 VPPSFRGG--------KQIDSINGTLPSYQKMQEEEPQKKLPV 361
P + + DS + +LP+ Q+ ++ +K V
Sbjct: 365 QPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSV 407
Score = 68.6 bits (166), Expect = 4e-11
Identities = 37/90 (41%), Positives = 51/90 (56%), Gaps = 1/90 (1%)
Query: 16 WAITSEERTKHDRQFDNLKPS-GGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKM 74
W IT E+R + QF +L+P +I+G A+NFF +S L P L+ IW LSD + DG +
Sbjct: 276 WRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGAL 335
Query: 75 DQQEFSIAMKLIKLKLQGQQLPVVLPPIMK 104
EF A LI + G LP LPP ++
Sbjct: 336 TLPEFCAAFHLIVARKNGYPLPEGLPPTLQ 365
>gi|125625322 RALBP1 associated Eps domain containing 2 isoform 2
[Homo sapiens]
Length = 659
Score = 90.9 bits (224), Expect = 7e-18
Identities = 97/342 (28%), Positives = 135/342 (39%), Gaps = 39/342 (11%)
Query: 47 NFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQP 106
+ F S LPA L +I L + G +F IA+KLI G LPV + I +
Sbjct: 77 DLFRASQLPAETLHQITELCGAKRVGYFGPTQFYIALKLIAAAQSG--LPVRIESIKCEL 134
Query: 107 PMFSPLISARFGMGSMPN--------LSIPQPLPPAAPITSLSSA----TSGTNLPPLMM 154
P+ ++S G N + IP + T + PL
Sbjct: 135 PLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQETQSPTMSPLAS 194
Query: 155 PTPLVPSVSTSSLPNGTASLI----QPLPIPYSSS---TLPHGSSYSLMMGGFGGASIQK 207
P P L +G + L Q P PY + P GSS GG G ++
Sbjct: 195 PPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSS----SGGPGTKPLRH 250
Query: 208 AQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQ 267
SLI S S L NS W + + R Y +F +L S ++SG
Sbjct: 251 QASLI-----RSFSVERELQDNSSYPD-EPWRITEEQREYYVNQFRSLQPDPSSFISGSV 304
Query: 268 ARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELV 327
A+N +S LS +L+ IW L+D D DG L EF A HL K G PLP LPP L
Sbjct: 305 AKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQ 364
Query: 328 PPSFRGG--------KQIDSINGTLPSYQKMQEEEPQKKLPV 361
P + + DS + +LP+ Q+ ++ +K V
Sbjct: 365 PEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSV 406
Score = 68.6 bits (166), Expect = 4e-11
Identities = 37/90 (41%), Positives = 51/90 (56%), Gaps = 1/90 (1%)
Query: 16 WAITSEERTKHDRQFDNLKPS-GGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKM 74
W IT E+R + QF +L+P +I+G A+NFF +S L P L+ IW LSD + DG +
Sbjct: 275 WRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGAL 334
Query: 75 DQQEFSIAMKLIKLKLQGQQLPVVLPPIMK 104
EF A LI + G LP LPP ++
Sbjct: 335 TLPEFCAAFHLIVARKNGYPLPEGLPPTLQ 364
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 90.5 bits (223), Expect = 9e-18
Identities = 90/400 (22%), Positives = 191/400 (47%), Gaps = 84/400 (21%)
Query: 346 SYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWE 405
+++K++EE+ +K+ +++++ ER E E+ R+ +++RE ER+ ++EKE+
Sbjct: 287 THKKLEEEKGKKE-----KERQEIEKERRERERERERERERREREREREREREREKEKER 341
Query: 406 RKQREL-QEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWER 464
++RE ++++ K+ + ++ E+ R+ +R+R +R KD R ++ ER+R E ER
Sbjct: 342 ERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERER 401
Query: 465 IRRQELLNQKNREQE-EIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTEL 523
R +E ++ RE+E E R ++K+ KK+ ++ +
Sbjct: 402 EREREREREREREREREREREREREKD------------------------KKRDREEDE 437
Query: 524 EVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHK 583
E + E ++L+++L+E ++ ER+KN + K
Sbjct: 438 E--------DAYERRKLERKLRE----------KEAAYQERLKNWEIRE---------RK 470
Query: 584 KSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNL 643
K+ E E+ +R +E+ + KE ++ +++ + DD
Sbjct: 471 KTREYEKEAEREEERRREMAKEAKRLKEFLEDYDD-----DRDDPKYY----------RG 515
Query: 644 FLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLEL------MQKKKLEDEAARKAK 697
L K LR+ + A E+ K ++++L+EI ++ L + +++E EA R+
Sbjct: 516 SALQKRLRDREKEME-ADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERR-- 572
Query: 698 QGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEE 737
++ K+ EEEE++K+ +EEK +E ++EEE ++
Sbjct: 573 --RQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
Score = 89.7 bits (221), Expect = 2e-17
Identities = 93/439 (21%), Positives = 196/439 (44%), Gaps = 79/439 (17%)
Query: 317 PLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNM 376
P+ +P L+ +++ L S + + + KKL ++ K E+
Sbjct: 249 PVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKL-----EEEKGKKEKERQ 303
Query: 377 ELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQR 436
E+EK R+ +++RE ER+ ++ + E ER++ + +E+E +++ + ++ K+R+ +R R
Sbjct: 304 EIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDR 363
Query: 437 EEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELE 496
E +R +D ER ++ R R +R R +E ++ RE+E R +++ E E
Sbjct: 364 ERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERE---RERERERERERERE 420
Query: 497 ALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVP 556
+ + KK+ ++ + E + E ++L+++L+E
Sbjct: 421 REREREKD----------KKRDREEDEE--------DAYERRKLERKLRE---------- 452
Query: 557 EKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSF 616
++ ER+KN + KK+ E E+ +R +E+ + KE ++ +
Sbjct: 453 KEAAYQERLKNWEIRE---------RKKTREYEKEAEREEERRREMAKEAKRLKEFLEDY 503
Query: 617 NNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIE 676
++ + DD K R + L K RD+ KE+E
Sbjct: 504 DD-----DRDDP-------------------KYYRGS---------ALQKRLRDREKEME 530
Query: 677 R-KRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKA 735
+R +K++LE+ R +G + E R E+E +++R + K + + +EEE +
Sbjct: 531 ADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEK 590
Query: 736 EEKQRKDKDTLKAEEKKRE 754
+EK+ K ++ ++ EE+ +
Sbjct: 591 QEKEEKREEPMEEEEEPEQ 609
Score = 46.6 bits (109), Expect = 1e-04
Identities = 31/142 (21%), Positives = 76/142 (53%), Gaps = 7/142 (4%)
Query: 347 YQKMQEEEPQKKLPVTFEDKRKA----NYERGNMELEKRRQALMEQQQREAERKAQKEKE 402
Y+K E E +++ + E KR +Y+ + + R + ++++ R+ E++ + ++
Sbjct: 475 YEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADER 534
Query: 403 EWERKQRELQEQEWKKQLELEKRLEKQRELERQREE-ERRKDIERREAAKQELERQRRLE 461
+ +R++ EL+E +++L E + EL+R +E ERR+ + ++ + E E + + E
Sbjct: 535 DRKREKEELEEI--RQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQE 592
Query: 462 WERIRRQELLNQKNREQEEIVR 483
E R + + ++ EQ+ ++
Sbjct: 593 KEEKREEPMEEEEEPEQKPCLK 614
Score = 43.9 bits (102), Expect = 0.001
Identities = 85/470 (18%), Positives = 189/470 (40%), Gaps = 86/470 (18%)
Query: 335 KQIDSINGTLPSYQKMQEEEPQ----------------KKLPVTFEDKRKANYERGNMEL 378
K++ +G L ++ + +EP+ KKL V + K KA + E
Sbjct: 117 KRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLD----EW 172
Query: 379 EKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREE 438
+ +++A + E +E + E K+R+ + + L E E +
Sbjct: 173 KAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSH 232
Query: 439 ERRKDIERREAAKQELERQRRLEWERIRRQEL--LNQKNREQEEIVRLNSKKKNLHLELE 496
R+K E++E + + + I ++++ + + +++ I R SK ++ H +LE
Sbjct: 233 PRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLE 292
Query: 497 ALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVP 556
GK + K+ Q+ E E +++ + ++ ++E +E +
Sbjct: 293 EEKGKKE------------KERQEIEKERRERERE------RERERERRERER------- 327
Query: 557 EKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSF 616
E++ ER K + ++ E++ R KE+ ++E + D
Sbjct: 328 EREREREREKEKE------------RERERERDRDRDRTKERDRDRDRER-----DRDRD 370
Query: 617 NNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIE 676
+ N D S RE ++ E+ + +R++ +E E
Sbjct: 371 RERSSDRNKDRS--------------------RSREKSRDRERERERERERERERERERE 410
Query: 677 RKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAE 736
R+R E ++++ E E + K+ +E ++ + + E++ R +E QE+++ E +
Sbjct: 411 RER-EREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRER 469
Query: 737 EKQRK-DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQ 785
+K R+ +K+ + EE++RE A + + D+ + G +Q
Sbjct: 470 KKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQ 519
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 90.1 bits (222), Expect = 1e-17
Identities = 123/546 (22%), Positives = 240/546 (43%), Gaps = 71/546 (13%)
Query: 247 KYRQKFNTLDKS---MSGYLSGFQA--------RNALLQSNLSQTQLATIWTLADVDGDG 295
+Y++K+ +L++ + G + +A + LQ Q QL T L +
Sbjct: 713 EYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK 772
Query: 296 QLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSIN-GTLPSYQKMQEEE 354
QL+ E+ I++ D+ K + L ++ +L KQI + TL K+Q EE
Sbjct: 773 QLEMEKEIVSSTRLDLQKKSEALE-SIKQKLTKQEEE--KQILKQDFETLSQETKIQHEE 829
Query: 355 PQKKLPVTFEDKRKANYERGNM--ELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQ 412
++ T + +K E+ + EL + L + K++ EKE + K L
Sbjct: 830 LNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILD 889
Query: 413 EQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQ-RRLEWERIRRQELL 471
++ K EL+ +L+ Q E + ++E +K +E+ + A +L+ + ++ + I+ Q L
Sbjct: 890 LEKTCK--ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947
Query: 472 NQKNREQEE----IVRLNSKKKNLHLELEALNGK-----------HQQISGRLQDVRLKK 516
Q +E+++ I L + ++EAL G+ ++ +L +
Sbjct: 948 KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1007
Query: 517 QTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQ---FSNT 573
+K ++ VL + KQLQ + +++L+ + + + E++ Q SN
Sbjct: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067
Query: 574 PDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCL 633
G + +L Q LK LE+++A K ++ Q +C + D +
Sbjct: 1068 NQIG---------NQNKLIQELKTAKATLEQDSAKKEQQL-----QERCKALQDIQKEKS 1113
Query: 634 LSLLSCLNNLFLLLKELRETYNTQQLAL----EQLYKIKRDKLKEI----ERKRLELMQK 685
L +N L E+ E Q+ + E+L K + +KEI + K+L + QK
Sbjct: 1114 LKEKELVNEKSKLA-EIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQK 1172
Query: 686 KKLEDEA-----ARKAKQGKENLWKENLRKEEEEKQKRL--QEEKTQEKIQEEE---RKA 735
+L+ +A A + ++ + + K+ ++KEEEE +K +E K +I+E+E +K
Sbjct: 1173 LELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKH 1232
Query: 736 EEKQRK 741
EE + K
Sbjct: 1233 EENEAK 1238
Score = 83.6 bits (205), Expect = 1e-15
Identities = 93/432 (21%), Positives = 201/432 (46%), Gaps = 51/432 (11%)
Query: 371 YERGNMELEKRRQALMEQQQR----EAERKAQKEKEEWERKQR-------ELQEQEWKKQ 419
Y+ + LE++ + L Q ++ E KA KE+ + +Q+ EL+ E KQ
Sbjct: 714 YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ 773
Query: 420 LELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWE------RIRRQELLNQ 473
LE+EK + L+ Q++ E + I+++ ++E ++ + ++E +I+ +EL N+
Sbjct: 774 LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833
Query: 474 KNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVR--LKKQTQKTELEVLD--KQ 529
E+ ++ +K+ L EL + K ++S L++ + +K+ QK + +LD K
Sbjct: 834 IQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKT 893
Query: 530 CDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHK-KSLEK 588
C E+ Q+Q E + K + EK+ ++ ++ + + + K EK
Sbjct: 894 CK-ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK 952
Query: 589 EELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLL-------------- 634
EE Q+L+ ++ L++ + K ++++ +LK + + L+ L
Sbjct: 953 EE--QQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE 1010
Query: 635 -SLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKL----- 688
+S L N + +E + + E R LK +E K L L Q+ +
Sbjct: 1011 KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK-LSLAQEDLISNRNQ 1069
Query: 689 ---EDEAARKAKQGKENLWKENLRKEE--EEKQKRLQEEKTQEKIQEEERKAEEKQRKDK 743
+++ ++ K K L +++ +KE+ +E+ K LQ+ + ++ ++E+E E+ + +
Sbjct: 1070 IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEI 1129
Query: 744 DTLKAEEKKRET 755
+ +K ++K T
Sbjct: 1130 EEIKCRQEKEIT 1141
Score = 70.9 bits (172), Expect = 7e-12
Identities = 91/400 (22%), Positives = 179/400 (44%), Gaps = 59/400 (14%)
Query: 383 QALMEQQQREAERKAQKEKEEWERKQRELQEQE-----WKKQL------------ELEKR 425
Q LM+ E ER+++K K+E ++ Q + E + +L EL+K
Sbjct: 234 QTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKL 293
Query: 426 LEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRR-QELLNQKNREQEEIV-R 483
EL Q+ + +++ ++E +LE + E + Q L+QK+ + +++ R
Sbjct: 294 KSSVNELT-QKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSR 352
Query: 484 LNSKKKNLH---LELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
L++ + +LH +EL Q++ L +V K Q K E + L +Q + + QL
Sbjct: 353 LSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQL 412
Query: 541 QQELQEYQNKLIYLVPEKQL--LNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQ 598
Q E+ + +KL L E+QL + R+K + L +K ++KE+ L+ +
Sbjct: 413 QSEINQLHSKL--LETERQLGEAHGRLKEQR---------QLSSEKLMDKEQQVADLQLK 461
Query: 599 LDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQ 658
L LE++ K++ +QL Q L + +LRE N +
Sbjct: 462 LSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTA---------KLREAQNDLE 512
Query: 659 LALEQLYKIKRDKLKEIE------RKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEE 712
L Q+ K K++ +E ++ + L++K++ + A +A +G + + +
Sbjct: 513 QVLRQIGD-KDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEG-----ETAVLNQL 566
Query: 713 EEKQKRLQEEKTQ--EKIQEEERKAEEKQRKDKDTLKAEE 750
+EK LQE+ TQ EK++ + ++ Q D ++ ++
Sbjct: 567 QEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK 606
Score = 65.5 bits (158), Expect = 3e-10
Identities = 88/401 (21%), Positives = 180/401 (44%), Gaps = 67/401 (16%)
Query: 378 LEKRRQALMEQQQR---------EAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEK 428
L+ + AL ++QQ + K Q ++E + + L+E + +K L LE++ E+
Sbjct: 669 LDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYK-EKYLSLEQKTEE 727
Query: 429 QRELERQREEERRKDIERREAAKQELERQRRLEWE-RIRRQELLNQKNREQEEIVRLNSK 487
++ E + + +E A Q+L++QR+L + +R EL Q E+E + +S
Sbjct: 728 LEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV---SST 784
Query: 488 KKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEY 547
+ +L + EAL Q+++ + ++ KQ K + E L ++ ++ E
Sbjct: 785 RLDLQKKSEALESIKQKLTKQEEE----KQILKQDFETLSQETKIQHEE----------- 829
Query: 548 QNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETA 607
LN RI+ V+ L K +EKE L L D L K +
Sbjct: 830 -------------LNNRIQTT---------VTELQKVKMEKEALMTELSTVKDKLSKVSD 867
Query: 608 SKLSEMDSFNNQLKCG-----NMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALE 662
S + F + + G +++ + + L + N KEL+++ ++ A
Sbjct: 868 SLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASH 927
Query: 663 QLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEE 722
QL K++ + ++E +L+Q + + ++ +Q + N+ L++ E+K+K+++
Sbjct: 928 QL-KLELNSMQE------QLIQAQNTLKQNEKEEQQLQGNI--NELKQSSEQKKKQIEAL 978
Query: 723 KTQEKIQEEERKAEEKQRKDKDTLKAEE--KKRETASVLVN 761
+ + KI ++ E + + + T A+E ++E SVL N
Sbjct: 979 QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQN 1019
Score = 63.9 bits (154), Expect = 9e-10
Identities = 91/385 (23%), Positives = 162/385 (42%), Gaps = 64/385 (16%)
Query: 377 ELEKRRQALMEQQ--QREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRE--- 431
+L+K +Q EQQ Q+ K ++ + + E+ R++ +++ K Q LE L+K +E
Sbjct: 482 QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ-NLEALLQKSKENIS 540
Query: 432 -LERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNRE-QEEIVRLNSKKK 489
LE++RE+ K I+ E L + L +KN QE++ +L K K
Sbjct: 541 LLEKEREDLYAK-IQAGEGETAVLNQ--------------LQEKNHTLQEQVTQLTEKLK 585
Query: 490 NLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVL-DKQCDLEIMEIKQLQQELQEYQ 548
N + H+Q L D + Q QK L D+ LE + +L +L E +
Sbjct: 586 N-------QSESHKQAQENLHD---QVQEQKAHLRAAQDRVLSLE-TSVNELNSQLNESK 634
Query: 549 NKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETAS 608
K+ L + + E + + + + T L+ LD +
Sbjct: 635 EKVSQLDIQIKAKTELLLSAEAAKTAQRA----------------DLQNHLDTAQNALQD 678
Query: 609 KLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIK 668
K E++ QL D V L + L LKE +E Y L+LEQ +
Sbjct: 679 KQQELNKITTQL------DQVTAKLQDKQEHCSQLESHLKEYKEKY----LSLEQKTEEL 728
Query: 669 RDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKI 728
++K++E LE+ K +++A + +Q ++ LR E KQ +++E
Sbjct: 729 EGQIKKLEADSLEV---KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTR 785
Query: 729 QEEERKAEEKQRKDKDTLKAEEKKR 753
+ ++K+E + + K EE+K+
Sbjct: 786 LDLQKKSEALESIKQKLTKQEEEKQ 810
Score = 60.8 bits (146), Expect = 8e-09
Identities = 98/474 (20%), Positives = 196/474 (41%), Gaps = 89/474 (18%)
Query: 375 NMELEKRRQALMEQQQREAERKAQKEKEEWERKQRE------LQEQEWKKQLELEKRLEK 428
N+ L++ L+ Q+ ++ + ++EK E ++E LQ+QE K + +
Sbjct: 77 NLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAE 136
Query: 429 QRELERQREE--------ERRKDIERREAA---------KQELERQRRL-EWERIRRQEL 470
+ LE+Q EE ++ KD+ ++AA K + + +R L E + L
Sbjct: 137 LQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRL 196
Query: 471 LNQKNREQ----------------EEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRL 514
+ N+E E++ L + + ++ + + ++ S +L+D
Sbjct: 197 TEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECK 256
Query: 515 KKQTQKTELEVLDKQCDLEI----MEIKQLQQELQEYQNKLIYLVPEKQLLNERI----- 565
K Q+Q E Q E+ E+ QELQ+ ++ + L + Q L E +
Sbjct: 257 KLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQ 316
Query: 566 -------KNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALE--------------- 603
K+ + S + + + LH+K L+ CQ+L+ +L A E
Sbjct: 317 DYTKLEEKHNEESVSKKNIQATLHQKDLD----CQQLQSRLSASETSLHRIHVELSEKGE 372
Query: 604 --KETASKLSEMDSFNNQLKC-----GNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNT 656
++ +LSE+++ LK + Q L L S +N L L E
Sbjct: 373 ATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGE 432
Query: 657 QQLALEQLYKIKRDKLKEIERKRLELMQK-KKLEDEAARKAKQGKENLWKENLRKEEEEK 715
L++ ++ +KL + E++ +L K +LE++ K E + + K++ ++
Sbjct: 433 AHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQE 492
Query: 716 QKRLQEEKT------QEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYR 763
Q+ LQ+ T Q +++ R+ +K +K ++ +K +E S+L R
Sbjct: 493 QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKER 546
Score = 44.3 bits (103), Expect = 7e-04
Identities = 59/245 (24%), Positives = 109/245 (44%), Gaps = 31/245 (12%)
Query: 332 RGGKQIDSINGTLPSYQKMQEEE-------PQKKLPVTFEDKRKANYERGNMELEKRRQA 384
R K+I +N L S++ +E Q + E + KA+ + +E EKR Q
Sbjct: 1135 RQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQ 1194
Query: 385 LMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDI 444
+++ Q +KE+EE ++E E+E K E+ K++E+ ++ EE +
Sbjct: 1195 ILKDQ-------VKKEEEE---LKKEFIEKEAKLHSEI-----KEKEVGMKKHEENEAKL 1239
Query: 445 ERREAAKQELERQRRLEWERIRRQ--ELLNQKNREQEEIVRLNSKKKNLHLELEALNGKH 502
+ A E + EW+ +R+ EL Q + + EI L + +N E AL +
Sbjct: 1240 TMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERC 1299
Query: 503 QQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLN 562
+ G ++ K QT+ EL+ ++ D +++L +E Q Q K + K +
Sbjct: 1300 LKGEGEIE----KLQTKVLELQ---RKLDNTTAAVQELGRENQSLQIKHTQALNRKWAED 1352
Query: 563 ERIKN 567
++N
Sbjct: 1353 NEVQN 1357
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 89.0 bits (219), Expect = 3e-17
Identities = 96/433 (22%), Positives = 201/433 (46%), Gaps = 95/433 (21%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEK---RRQALMEQQQREAER--------- 395
++++E+ + + + + K+ + EL++ R + L+ QQQ +AE
Sbjct: 205 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 264
Query: 396 -----KAQKEKEE-WERKQRELQEQEWKKQLELEKRLEKQRELE---RQREEERRKDIER 446
+AQ E+ E W R ++ +E+ W+++ ++++R EK +E E R++EE+ R+ E
Sbjct: 265 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEM 324
Query: 447 REAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS 506
++++ RQ + WE+ + L +K EQE+I K++ E + Q+
Sbjct: 325 MWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK 384
Query: 507 GRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIK 566
Q+ ++++Q +K I++ ++ +QE + K+ +++ + E+ +
Sbjct: 385 MWRQEEKIREQEEK----------------IREQEEMMQEQEEKM---GEQEEKMWEQEE 425
Query: 567 NMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEK---ETASKLSEMDSF--NNQLK 621
MQ E+EE +R +E++ EK E K+ E + + K
Sbjct: 426 EMQ-----------------EQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 468
Query: 622 CGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLE 681
G + + + +E +Q E+ + + +K++E E+K E
Sbjct: 469 MGEQEGKMCE-------------------QEAKMQEQ---EEKMRRQEEKIREQEKKIRE 506
Query: 682 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
Q++K+ ++ +Q +E +W E+EEK QEEK QE+ +E+ R+ EEK R+
Sbjct: 507 --QEEKIREQEEMMQEQ-EEKMW------EQEEKMCE-QEEKMQEQ-EEKMRRQEEKMRE 555
Query: 742 DKDTLKAEEKKRE 754
+ L+ +E+K +
Sbjct: 556 QEVRLRQQEEKMQ 568
Score = 80.5 bits (197), Expect = 9e-15
Identities = 76/338 (22%), Positives = 172/338 (50%), Gaps = 24/338 (7%)
Query: 297 LKAEEFILAMHLTDMAKAGQPLPLTLPPE-LVPPSFRGGKQIDSINGTLPSYQKMQEEEP 355
+++E+ + +++ ++ + + L LP + L + GK++ S++ L + +++E E
Sbjct: 221 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA--QVEENEL 278
Query: 356 QKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQ--REAERKAQKEKE---EWERKQRE 410
+L E+K E+ +++R + + EQ++ RE E K ++++E E E K R
Sbjct: 279 WNRLNQQQEEKMWRQEEK----IQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRR 334
Query: 411 LQEQEWKKQLELEKRLEKQRELERQREEERRKDIE---RREAAKQELERQRRLEWERIRR 467
+E W+K+ ++ + EK E E+ RE+E ++ E R + +QE E + + E+IR
Sbjct: 335 QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 394
Query: 468 QELLNQKNREQEEIVRLNSKKKNLHLEL---EALNGKHQQISGRLQDVRLKKQTQKTELE 524
QE +K REQEE+++ +K E + + Q+ R Q+ ++++Q +K E
Sbjct: 395 QE---EKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIR-E 450
Query: 525 VLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFS-NTPDSGVSLLHK 583
+K + E M +++ ++++ E + K+ + Q E+++ + + + +
Sbjct: 451 QEEKIREQEEM-MQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEE 509
Query: 584 KSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLK 621
K E+EE+ Q +E++ E++ + +M +++
Sbjct: 510 KIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 547
Score = 73.2 bits (178), Expect = 1e-12
Identities = 84/406 (20%), Positives = 185/406 (45%), Gaps = 50/406 (12%)
Query: 364 EDKRKANYE-----RGNMELEKRRQALMEQQQREAERK---AQKEKEEWERKQRELQEQ- 414
ED++KA+++ R +E + + ++ Q+ E + +Q ++ E + R+L +
Sbjct: 96 EDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 155
Query: 415 --EWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLN 472
WK ELE+ L +++ + + + R+A EL R I +EL
Sbjct: 156 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNT------ITDEELKE 209
Query: 473 QKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDL 532
+ + QE++ + S+K + L ++ L K ++ L +L+ + E+ L
Sbjct: 210 KNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKL 269
Query: 533 EI-MEIKQLQQELQEYQNKLIYLVPEK-QLLNERIKNMQFS-NTPDSGVSLLHKKSLEKE 589
+ +E +L L + Q + ++ EK Q E+I+ + + + + EKE
Sbjct: 270 QAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKE 329
Query: 590 ELCQRLKEQLDALE---KETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLL 646
E +R +E + E +E K+ E + Q + ++ + +
Sbjct: 330 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE--------------- 374
Query: 647 LKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKE 706
+E R+ + E+ + + +K++E E E+MQ+++ K + +E +W++
Sbjct: 375 -QEKRQEQEAKMWRQEEKIREQEEKIREQE----EMMQEQE------EKMGEQEEKMWEQ 423
Query: 707 NLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKK 752
+E+E++ R QEEK +E+ +++ R+ EEK R+ ++ ++ +E+K
Sbjct: 424 EEEMQEQEEKMRRQEEKIREQ-EKKIREQEEKIREQEEMMQEQEEK 468
Score = 68.6 bits (166), Expect = 4e-11
Identities = 57/219 (26%), Positives = 120/219 (54%), Gaps = 32/219 (14%)
Query: 351 QEEEPQKKLPVTFEDKRK---ANYERGNMELEKRRQALMEQQ---QREAERKAQKEKEEW 404
QEE+ Q++ + ++KR+ A R ++ ++ + + EQ+ Q + E+ ++E++ W
Sbjct: 362 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMW 421
Query: 405 ERKQRELQEQEWK------KQLELEKRLEKQRELERQREEERRKDIER----------RE 448
E+++ E+QEQE K K E EK++ +Q E R++EE ++ E+ +E
Sbjct: 422 EQEE-EMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQE 480
Query: 449 AAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGR 508
A QE E + R + E+IR QE +K REQEE +R +++ + E E + ++ +
Sbjct: 481 AKMQEQEEKMRRQEEKIREQE---KKIREQEEKIR---EQEEMMQEQEEKMWEQEE---K 531
Query: 509 LQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEY 547
+ + K Q Q+ ++ +++ + + ++Q ++++QE+
Sbjct: 532 MCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQEH 570
Score = 62.4 bits (150), Expect = 3e-09
Identities = 48/220 (21%), Positives = 120/220 (54%), Gaps = 13/220 (5%)
Query: 335 KQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAE 394
++I + + +K++E+E +++ E+K + +R E + RQ ++Q E
Sbjct: 344 EKIRELEEKMHEQEKIREQEEKRQE----EEKIREQEKRQEQEAKMWRQEEKIREQEEKI 399
Query: 395 RKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQ-REEERRKDIERREAAKQE 453
R+ ++ +E E K E +E+ W+++ E++++ EK R E + RE+E K I +E +E
Sbjct: 400 REQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQE--KKIREQEEKIRE 457
Query: 454 LERQRRLEWERIRRQE--LLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQD 511
E + + E++ QE + Q+ + QE+ ++ +++ + + + + + ++I R Q+
Sbjct: 458 QEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKI--REQE 515
Query: 512 VRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKL 551
+++Q +K E +K C+ E ++++ +++++ + K+
Sbjct: 516 EMMQEQEEKM-WEQEEKMCEQE-EKMQEQEEKMRRQEEKM 553
Score = 62.0 bits (149), Expect = 3e-09
Identities = 78/374 (20%), Positives = 174/374 (46%), Gaps = 71/374 (18%)
Query: 437 EEERRKDIERREAAKQELERQ-RRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLEL 495
E+E++ + +EA ++ELE Q + + ++ EL Q + +L + ++L L
Sbjct: 96 EDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 155
Query: 496 EALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEI-------KQLQQELQEYQ 548
++ L V +K+ +E L K+ D +E+ ++L+++ + Q
Sbjct: 156 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 215
Query: 549 NKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELC---QRLKEQLDALEKE 605
KL + EK + +K + K+ LE+ +L Q+L+ + D L KE
Sbjct: 216 EKLQLVESEKSEIQLNVKEL--------------KRKLERAKLLLPQQQLQAEADHLGKE 261
Query: 606 TASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLY 665
S +++ + + EL N QQ E+++
Sbjct: 262 LQSVSAKLQAQVEE----------------------------NELWNRLNQQQE--EKMW 291
Query: 666 KIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWK--ENLRKEEE---EKQKRLQ 720
+ + +K++E E K E +K + ++E K ++ +E +W+ E +R++EE EK+++++
Sbjct: 292 R-QEEKIQEREEKIQEQEEKIREQEE---KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 347
Query: 721 EEKTQEKIQEEER-KAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFN 779
E +EK+ E+E+ + +E++R++++ ++ +EK++E + + + R +E
Sbjct: 348 E--LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE----KIREQEEKIRE 401
Query: 780 SGDIIQVDEKTVGE 793
+++Q E+ +GE
Sbjct: 402 QEEMMQEQEEKMGE 415
Score = 54.7 bits (130), Expect = 5e-07
Identities = 39/147 (26%), Positives = 77/147 (52%), Gaps = 14/147 (9%)
Query: 349 KMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQ 408
+ QEE+ +++ E + K + M+ ++ + E + E E K Q+++E+ R++
Sbjct: 435 RRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQE 494
Query: 409 RELQEQEWKKQLELEKRLEKQRELERQREE---ERRKDIERREAAKQELERQRRLEWERI 465
+++EQE K++ +Q E R++EE E+ + + +E E E + + + E++
Sbjct: 495 EKIREQE--------KKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKM 546
Query: 466 RRQELLNQKNREQEEIVRLNSKKKNLH 492
RRQE +K REQE +R +K H
Sbjct: 547 RRQE---EKMREQEVRLRQQEEKMQEH 570
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 89.0 bits (219), Expect = 3e-17
Identities = 89/415 (21%), Positives = 196/415 (47%), Gaps = 41/415 (9%)
Query: 344 LPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEE 403
LP Q E + K + K +A E EL R E++ E K Q+ +E+
Sbjct: 319 LPQQQLQAEADHLGKELQSVSAKLQAQVEEN--ELWNRLNQQQEEKMWRQEEKIQEWEEK 376
Query: 404 WERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWE 463
+ ++ +++EQE +K E E+++ +Q E+ ++EE+ R+ E ++++ RQ + WE
Sbjct: 377 IQEQEEKIREQE-EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 435
Query: 464 RIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKT-E 522
+ + L +K EQE+I K++ E + Q+ Q+ ++++Q +K E
Sbjct: 436 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 495
Query: 523 LEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLH 582
E + + +I E +++++E + + + ++ EK E I + +
Sbjct: 496 QEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK------EKIHEQE 549
Query: 583 KKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNN 642
+K ++EE R +E++ ++E + E + + K ++ +
Sbjct: 550 EKIRKQEEKMWRQEEKMH--DQEEKIREQEEKVWRQEEKIREQEEKI------------- 594
Query: 643 LFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKEN 702
+E E Q E++ + + +K+ E E K E Q++K++++ + +Q ++
Sbjct: 595 -----REQEEKIREQ----EEMTQEQEEKMGEQEEKMCE--QEEKMQEQEEKMRRQEEKI 643
Query: 703 LWKENLRKEEEEKQKRLQE--EKTQEKIQEEERK---AEEKQRKDKDTLKAEEKK 752
+E +E+EEK + +E ++ +EK+ E+E K EEK ++ ++ ++ +E+K
Sbjct: 644 REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 698
Score = 84.7 bits (208), Expect = 5e-16
Identities = 105/483 (21%), Positives = 223/483 (46%), Gaps = 85/483 (17%)
Query: 297 LKAEEFILAMHLTDMAKAGQPLPLTLPPE-LVPPSFRGGKQIDSINGTLPSYQKMQEEEP 355
+++E+ + +++ ++ + + L LP + L + GK++ S++ L + +++E E
Sbjct: 294 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA--QVEENEL 351
Query: 356 QKKLPVTFEDK---RKANYERGNMELEKRRQALMEQQQ--REAERKAQK------EKEE- 403
+L E+K ++ + +++++ + + EQ++ RE E K ++ EKEE
Sbjct: 352 WNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEK 411
Query: 404 --------WER--KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIE---RREAA 450
WE+ K R +E W+K+ ++ + EK E E+ RE+E ++ E R +
Sbjct: 412 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 471
Query: 451 KQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQ 510
+QE E + + E+IR QE +K REQEE + +K H+Q R +
Sbjct: 472 RQEQEAKMWRQEEKIREQE---EKIREQEEKMWRQEEK------------IHEQEKIREE 516
Query: 511 DVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQF 570
+ R +++ + E + +Q EI + ++++ E + K I EK E + Q
Sbjct: 517 EKRQEQEEMWRQEEKIREQ-----EEIWRQKEKIHEQEEK-IRKQEEKMWRQEEKMHDQ- 569
Query: 571 SNTPDSGVSLLHKKSLEKEELCQRLKEQLDALE---KETASKLSEMDSFNNQL--KCGNM 625
+K E+EE R +E++ E +E K+ E + + K G
Sbjct: 570 -----------EEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQ 618
Query: 626 DDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQK 685
++ + E E Q+ + + + R++ K+I + ++ ++
Sbjct: 619 EEKMC------------------EQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ 660
Query: 686 KKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDT 745
+++ E K + +E + ++ + +E+E++ R QEEK E+ + R+ EEK ++ ++
Sbjct: 661 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ-EVRLRQQEEKMQEHQEH 719
Query: 746 LKA 748
L+A
Sbjct: 720 LEA 722
Score = 80.9 bits (198), Expect = 7e-15
Identities = 98/448 (21%), Positives = 205/448 (45%), Gaps = 84/448 (18%)
Query: 354 EPQKKLPVTFEDKRKANY-------ERGNMELEKRRQALMEQQQREAERKAQKEKE--EW 404
E ++ L K+KA+ ER + LE R + +++ +E K Q++ + E
Sbjct: 237 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVES 296
Query: 405 ERKQRELQEQEWKKQLELEKRLEKQRELERQ-------------------REEERRKDIE 445
E+ + +L +E K++LE K L Q++L+ + E E +
Sbjct: 297 EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLN 356
Query: 446 RREAAKQELERQRRLEW-ERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQ 504
+++ K + ++ EW E+I+ QE +K REQEE +R +K E + + ++
Sbjct: 357 QQQEEKMWRQEEKIQEWEEKIQEQE---EKIREQEEKIREQEEKMR---RQEEMMWEKEE 410
Query: 505 ISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNER 564
R +++ +K+ + E + + + +I E+++ E ++ + + EK+ E+
Sbjct: 411 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ-----EEKRQEEEK 465
Query: 565 IKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGN 624
I+ + ++ + +K E+EE +++EQ + + ++ K+ E + + K
Sbjct: 466 IREQEKRQEQEAKMWRQEEKIREQEE---KIREQEEKMWRQ-EEKIHEQEKIREEEKRQE 521
Query: 625 MDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQ 684
++ Q ++E E + ++ EQ KI++ + K Q
Sbjct: 522 QEEMWRQ------------EEKIREQEEIWRQKEKIHEQEEKIRKQEEK-------MWRQ 562
Query: 685 KKKLEDEAARKAKQGKENLWK--ENLRKEEE-----EKQKRLQEEKTQ---EKIQEEERK 734
++K+ D+ K ++ +E +W+ E +R++EE E++ R QEE TQ EK+ E+E K
Sbjct: 563 EEKMHDQ-EEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEK 621
Query: 735 ----------AEEKQRKDKDTLKAEEKK 752
EEK R+ ++ ++ +EKK
Sbjct: 622 MCEQEEKMQEQEEKMRRQEEKIREQEKK 649
Score = 73.2 bits (178), Expect = 1e-12
Identities = 100/439 (22%), Positives = 192/439 (43%), Gaps = 65/439 (14%)
Query: 364 EDKRKANYE-----RGNMELEKRRQALMEQQQREAERK---AQKEKEEWERKQRELQEQ- 414
ED++KA+++ R +E + ++ Q+ E + +Q ++ E + R+L +
Sbjct: 169 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 228
Query: 415 --EWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQ----RRLEWERIRRQ 468
WK ELE+ L +++ + + + R+A EL R L+ + + Q
Sbjct: 229 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 288
Query: 469 ELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGR-------LQDVRLKKQTQKT 521
E L E+ EI +LN K+ LE L QQ+ LQ V K Q Q
Sbjct: 289 EKLQLVESEKSEI-QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 347
Query: 522 ELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLL 581
E E+ ++ + ++ + ++++QE++ K+ Q E+I+ +
Sbjct: 348 ENELWNRLNQQQEEKMWRQEEKIQEWEEKI-------QEQEEKIREQE------------ 388
Query: 582 HKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLN 641
+K E+EE +R +E + EKE + E + + K ++ + + +
Sbjct: 389 -EKIREQEEKMRRQEEMM--WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI----- 440
Query: 642 NLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAAR----KAK 697
+EL E + Q+ EQ K + ++ + KR E K ++E R K +
Sbjct: 441 ------RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 494
Query: 698 QGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRE-TA 756
+ +E +W++ + E+EK + +EEK QE QEE + EEK R+ ++ + +EK E
Sbjct: 495 EQEEKMWRQEEKIHEQEKIR--EEEKRQE--QEEMWRQEEKIREQEEIWRQKEKIHEQEE 550
Query: 757 SVLVNYRALYPFEARNHDE 775
+ ++ E + HD+
Sbjct: 551 KIRKQEEKMWRQEEKMHDQ 569
Score = 45.4 bits (106), Expect = 3e-04
Identities = 32/103 (31%), Positives = 60/103 (58%), Gaps = 6/103 (5%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
+KMQE+E + + E+K + ++ + EK R+ E+ +E E K +++E+ +
Sbjct: 627 EKMQEQEEKMRRQ---EEKIREQEKKIREQEEKIRE--QEEMMQEQEEKMWEQEEKMCEQ 681
Query: 408 QRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAA 450
+ ++QEQE K + + EK E++ L RQ+EE+ ++ E EAA
Sbjct: 682 EEKMQEQEEKMRRQEEKMWEQEVRL-RQQEEKMQEHQEHLEAA 723
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 88.2 bits (217), Expect = 4e-17
Identities = 109/446 (24%), Positives = 212/446 (47%), Gaps = 34/446 (7%)
Query: 335 KQIDSINGTLPS-YQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREA 393
KQ+++IN L + Q++ E+E Q + E + K N + E K + + ++ + +
Sbjct: 1512 KQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKM 1571
Query: 394 ERKAQKEKEEWERKQRELQEQEWKK------QLELEKRLEKQRELERQREEERRKDIERR 447
+ +E E Q ++E+E K Q+E ++ E +E+ + +E + K+ +
Sbjct: 1572 LELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFL 1631
Query: 448 EAAKQELERQRRLEWERIRRQ---ELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQ 504
+ +++ E E ++ Q + LN +N E E I +NL E+ ++ +
Sbjct: 1632 KMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLE-EMRSVTKERDD 1690
Query: 505 ISG-----RLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQ 559
+ +++ +LK+ ++T L+KQ +L+I+ + +E QE +KL +V EK
Sbjct: 1691 LRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMH--LKEHQETIDKLRGIVSEK- 1747
Query: 560 LLNERIKNMQFSNTPDSGVSLLHKKSLEKEEL---CQRLKEQLDALEKETASKLSEMDSF 616
I NMQ + S +L + +EEL LKEQ + ++K + D
Sbjct: 1748 --TNEISNMQ-KDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKL 1804
Query: 617 NNQLK-CGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDK---L 672
+N K N + + + + L + + L L K++ ET + +EQL K +D+ L
Sbjct: 1805 SNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNET-QKKVSEMEQLKKQIKDQSLTL 1863
Query: 673 KEIERKRLELMQKKKLEDEAARKAKQGKENLWK--ENLRKEEEEKQKRLQEEKTQE-KIQ 729
++E + L L QK E + + ++NL + E L+ E ++ ++ LQE K ++ +IQ
Sbjct: 1864 SKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQ 1923
Query: 730 EEERKAEEKQRKDKDTL-KAEEKKRE 754
+E + A ++ K+T+ K EK E
Sbjct: 1924 QELKTARMLSKEHKETVDKLREKISE 1949
Score = 75.1 bits (183), Expect = 4e-13
Identities = 111/478 (23%), Positives = 210/478 (43%), Gaps = 43/478 (8%)
Query: 338 DSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKA 397
+ + L S ++ QE K ++ E R + E E + Q M ++ + +A
Sbjct: 964 EQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEA 1023
Query: 398 QKEKE-EWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELER 456
+ + + K E+ EQ+ K ++++ E Q+ LE E+ + + +E + +E
Sbjct: 1024 KNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIEN 1083
Query: 457 QRRLEW---ERIRRQELLNQ-KNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDV 512
Q L E ++QE++ Q KN ++ L+ L E L K QQ+ + Q +
Sbjct: 1084 QEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQL 1143
Query: 513 RLKKQTQKTEL------------EVLDKQCDLEIMEIKQLQ--QELQEYQNKLIYLVPEK 558
L Q + +E+ E+ +K+ LE ME ++L+ Q+L E ++ + E+
Sbjct: 1144 -LNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKER 1202
Query: 559 QLLNERIKNMQFSNTPDSG-VSLLHKKSLE-KEEL------CQRLKEQLDALEKETASKL 610
++L E K+ + G + + L+ KEEL + +E +D L + + K
Sbjct: 1203 KVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKT 1262
Query: 611 SEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRD 670
+++ + + K + L L N+ + E +ET N +L EQ
Sbjct: 1263 AQIINTQDLEKSHTKLQEEIPVLHEEQELLPNV-KEVSETQETMNELELLTEQSTTKDST 1321
Query: 671 KLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEE--KTQEKI 728
L IE +RL L +K + E + + ++NL + +++ E K +L+E +T KI
Sbjct: 1322 TLARIEMERLRLNEKFQESQEEIKSLTKERDNL--KTIKEALEVKHDQLKEHIRETLAKI 1379
Query: 729 QEEERKAEEK---QRKDKDTLK----AEEKKRETASVL---VNYRALYPFEARNHDEM 776
QE + K E+ + KD +T K E+ K + +++L + L +HDEM
Sbjct: 1380 QESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEM 1437
Score = 72.0 bits (175), Expect = 3e-12
Identities = 103/457 (22%), Positives = 195/457 (42%), Gaps = 42/457 (9%)
Query: 335 KQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAE 394
++ DS G L + + +E Q+K T E + + N E + R + ++ +RE
Sbjct: 855 QKFDSSLGALKTELSYKTQELQEK---TREVQERLNEMEQLKEQLENRDSTLQTVEREKT 911
Query: 395 RKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQEL 454
+K ++ E + QE++ KQL+ ++E+ +L+ + +I+ +E + L
Sbjct: 912 LITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERD-QLKSDIHDTVNMNIDTQEQLRNAL 970
Query: 455 ERQRRLEWERIRRQELLNQ-KNREQEEIVRLNSKKKNLHLEL---EALNGKHQQISG--R 508
E + + QE +N K++ EE+ R NLH+E E + Q++ G +
Sbjct: 971 ESLK-------QHQETINTLKSKISEEVSR------NLHMEENTGETKDEFQQKMVGIDK 1017
Query: 509 LQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIK-N 567
QD+ K TQ +V D + + +I L QE E Q L ++ EK+ L +K N
Sbjct: 1018 KQDLE-AKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKEN 1076
Query: 568 MQFSNTPDSGVSLL--------------HKKSLEKEELCQRLKEQLDALEKETASKLSEM 613
++ + + LL +++KE R ++L +E++ K ++
Sbjct: 1077 IEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQL 1136
Query: 614 DSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLK 673
QL + S +Q ++ + L N + E T++L L Q +++K
Sbjct: 1137 QEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVK 1196
Query: 674 EIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEER 733
I ++R L + +K + + + L+ +EE K + ++ QE I E R
Sbjct: 1197 SITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRR 1256
Query: 734 KAEEKQRK---DKDTLKAEEKKRETASVLVNYRALYP 767
EK + +D K+ K +E VL + L P
Sbjct: 1257 SVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLP 1293
Score = 70.5 bits (171), Expect = 1e-11
Identities = 96/413 (23%), Positives = 178/413 (43%), Gaps = 55/413 (13%)
Query: 368 KANYERGNMELEKRRQALMEQQQREAERKAQK-EKEEWERKQRELQEQEWKKQLELEKRL 426
K + ++ L++ ++ + E ++ +E+ AQ ++ E+ +LQE E E ++ L
Sbjct: 1234 KEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQE-EIPVLHEEQELL 1292
Query: 427 EKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNRE-QEEIVRLN 485
+E+ +E ++ ++ ++ R+E ER+R LN+K +E QEEI L
Sbjct: 1293 PNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLR----LNEKFQESQEEIKSLT 1348
Query: 486 SKKKNLHLELEALNGKHQQISGRLQDV--RLKKQTQKTELEVLDKQCDLEIMEIKQLQQE 543
++ NL EAL KH Q+ +++ ++++ K E + K+ D E +I E
Sbjct: 1349 KERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVS---E 1405
Query: 544 LQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALE 603
+++++ K + LL I+ + S + + EK++L QRL+E L
Sbjct: 1406 MEQFKPK------DSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL-QRLQEVLQ--- 1455
Query: 604 KETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQ 663
SE D +K ++ L L LKE ET N ++ L +
Sbjct: 1456 -------SESDQLKENIK------EIVAKHLETEEELKVAHCCLKEQEETINELRVNLSE 1502
Query: 664 LYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEK 723
K ++ I+ K+LE + K +N +E KEE+ K++ E
Sbjct: 1503 ----KETEISTIQ-KQLEAINDKL-------------QNKIQEIYEKEEQFNIKQISE-- 1542
Query: 724 TQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEM 776
QEK+ E ++ E ++ KD E K E + L + + +EM
Sbjct: 1543 VQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEM 1595
Score = 63.5 bits (153), Expect = 1e-09
Identities = 96/469 (20%), Positives = 193/469 (41%), Gaps = 64/469 (13%)
Query: 377 ELEKRRQALMEQQQREAERK--AQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELER 434
EL L +QQ+ A+ K A K++ E R L E E K + + ++ EKQ++L
Sbjct: 1086 ELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLN 1145
Query: 435 QREE--ERRKDIERREAAKQELE-RQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNL 491
+EE E +K I E K EL+ ++ LE R EL + N EE+ + ++K L
Sbjct: 1146 VQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVL 1205
Query: 492 HLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLD---KQCDLEIMEIKQL-------- 540
++ + + G ++++ K EL++ K+ I E+++
Sbjct: 1206 KELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQI 1265
Query: 541 --QQELQEYQNKLIYLVP---EKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQ-- 593
Q+L++ KL +P E+Q L +K + + + + LL ++S K+
Sbjct: 1266 INTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLAR 1325
Query: 594 ------RLKEQLDALEKETASKLSEMDSFNN-----QLKCGNMDDSVLQCL--------- 633
RL E+ ++E S E D+ ++K + + + + L
Sbjct: 1326 IEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSK 1385
Query: 634 ----LSLLSCLNNLFLLLKELRE---------TYNTQQLALEQLYKIKRDKLKEIERKRL 680
L++ N ++ E+ + + L L + + D++K + +++
Sbjct: 1386 QEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKD 1445
Query: 681 ELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQR 740
+L + +++ + + K+ + + ++L EEE K ++ +E I E EK+
Sbjct: 1446 DLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKET 1505
Query: 741 KDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEK 789
+ + +K+ E +N + + E FN I +V EK
Sbjct: 1506 E----ISTIQKQLEA----INDKLQNKIQEIYEKEEQFNIKQISEVQEK 1546
Score = 62.0 bits (149), Expect = 3e-09
Identities = 92/451 (20%), Positives = 181/451 (40%), Gaps = 62/451 (13%)
Query: 345 PSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEW 404
P+ + + +E + +L + +A+Y+ ++ E+ R E + + E+ E E
Sbjct: 486 PATKLLNQENIESEL-----NSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL 540
Query: 405 ERKQRELQEQEWKKQL---------------ELEKRLEKQRELERQREEERRK-----DI 444
ERK ++ QE + ++ +LE L + EL R++E++ +K D
Sbjct: 541 ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS 600
Query: 445 ERREAAKQEL-------ERQRRLEWERIRRQELLNQKNRE----QEEIVRLNSKKKNLHL 493
++ E K +L E ++++ + + RE + E + L K K L
Sbjct: 601 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT 660
Query: 494 ELEALNGKHQQISGRLQ-----DVRLKKQTQKTELEV------LDKQCDLEIMEIKQLQQ 542
+ + Q +L+ V L+K+ Q E+ +D + +++ +L+
Sbjct: 661 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG 720
Query: 543 ELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDAL 602
++ + Q +L V E + L E + + + S V L K+ +K E + + D L
Sbjct: 721 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL 780
Query: 603 EKETASKLSEMDSFNNQLKCGNMD-----------DSVLQCLLSLLSCLNNLFLLLKELR 651
E K S + ++ D D Q +L + ++ E
Sbjct: 781 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN 840
Query: 652 ETYNTQQLALE---QLYKIKRDKLK-EIERKRLELMQKKKLEDEAARKAKQGKENLWKEN 707
E N + + L Q + LK E+ K EL +K + E + +Q KE L +
Sbjct: 841 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
Query: 708 LRKEEEEKQKRLQEEKTQEKIQEEERKAEEK 738
+ E++K L EK Q+ ++E + +EK
Sbjct: 901 STLQTVEREKTLITEKLQQTLEEVKTLTQEK 931
Score = 59.7 bits (143), Expect = 2e-08
Identities = 98/459 (21%), Positives = 196/459 (42%), Gaps = 52/459 (11%)
Query: 337 IDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERK 396
ID + G + +K E +K D KA + EL L EQQ+ + +
Sbjct: 1737 IDKLRGIVS--EKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLR 1794
Query: 397 A--QKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREE--ERRKDIERREAAKQ 452
++ ++ Q++L+ K Q ++++ + +L +++ E +K + E K+
Sbjct: 1795 GIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKK 1854
Query: 453 ELERQR----RLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGR 508
+++ Q +LE E + + L++ E + +++ ++ NL E L + Q+
Sbjct: 1855 QIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMK---ERDNLRRVEETLKLERDQLKES 1911
Query: 509 LQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNM 568
LQ+ + + D + E+ + L +E +E +KL + EK + +I ++
Sbjct: 1912 LQETKAR-----------DLEIQQELKTARMLSKEHKETVDKLREKISEKTI---QISDI 1957
Query: 569 QFSNTPDSGVSLLHKK--SLEKEEL-CQRLKEQLDALEKETASKLSEMDSFNNQLKCGNM 625
Q D L KK L+K+EL R+KE ++ K K++EM+ Q + N
Sbjct: 1958 Q--KDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHK----KINEMEQLKKQFEAQN- 2010
Query: 626 DDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKR--DKLKEIERKRLELM 683
LS+ S + F L K+L E+ ++ ++ +++R + LK + + +
Sbjct: 2011 --------LSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATL 2062
Query: 684 QKKKLEDEAARKAKQGKENL--WKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
++ D + K K L +++L + EK R++E ++ E + E R
Sbjct: 2063 REMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKE--LLKRYSEMDDHYECLNRL 2120
Query: 742 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 780
D K E ++E S+ V P+ H E F +
Sbjct: 2121 SLDLEKEIEFQKE-LSMRVKANLSLPYLQTKHIEKLFTA 2158
Score = 58.2 bits (139), Expect = 5e-08
Identities = 94/437 (21%), Positives = 191/437 (43%), Gaps = 67/437 (15%)
Query: 375 NMELEKRRQALMEQQQREAERKAQKEKE------------EWERKQRELQEQE------- 415
N+ELE + L ++ +E E +E E ER ++E+Q++
Sbjct: 715 NLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIIT 774
Query: 416 ------WKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQE 469
+ + + E R++ E + +++ ++ QE + + L + ++ +
Sbjct: 775 SEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYK 834
Query: 470 LLNQKN-REQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDK 528
++ ++N R +EIV L+ + + L AL + + LQ+ + Q + E+E L +
Sbjct: 835 MVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKE 894
Query: 529 QCD-----LEIMEIKQ--LQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLL 581
Q + L+ +E ++ + ++LQ+ ++ L EK L + +++Q D S +
Sbjct: 895 QLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIER--DQLKSDI 952
Query: 582 HKKSLEKEELCQRLKEQLDALEKE------TASKLSEMDSFNNQLK--CGNMDDSVLQCL 633
H + ++L+ L++L++ SK+SE S N ++ G D Q +
Sbjct: 953 HDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKM 1012
Query: 634 LSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAA 693
+ + K+ E NTQ L + +K +++ E +RK L+Q+K +
Sbjct: 1013 VGIDK---------KQDLEAKNTQTLTAD----VKDNEIIEQQRKIFSLIQEKNELQQML 1059
Query: 694 RKAKQGKENL---WKENLRK--EEEEKQKRLQEE--KTQEKIQEEERKAEEKQRKDKDT- 745
KE L KEN+ E +E+ + L +E K QE + +E+ A +K+ + T
Sbjct: 1060 ESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTC 1119
Query: 746 ---LKAEEKKRETASVL 759
+ EEK +E + L
Sbjct: 1120 DRLAEVEEKLKEKSQQL 1136
Score = 51.6 bits (122), Expect = 5e-06
Identities = 82/384 (21%), Positives = 155/384 (40%), Gaps = 66/384 (17%)
Query: 384 ALMEQQQREAERKAQKEKEEWERKQRELQEQE---WKKQLELEKRLEKQRELERQREEER 440
A+M + ER A KE WE+ + L+E+ +K L+ L ++ ++ +
Sbjct: 2309 AIMNESTEFEERSATISKE-WEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNK 2367
Query: 441 RKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNG 500
+ R +L E+IR EL N + +E + SK + ELE N
Sbjct: 2368 NPHVTSRAT---------QLTTEKIR--ELENSLHEAKESAMHKESKIIKMQKELEVTND 2416
Query: 501 KHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQL 560
++ ++ + + K ++VL D + K ++E+++ + KL+ + EK +
Sbjct: 2417 IIAKLQAKVHESNKCLEKTKETIQVLQ---DKVALGAKPYKEEIEDLKMKLVKIDLEK-M 2472
Query: 561 LNERIKNMQFSNTPDSGVSLLHKKSLE-KEELCQRLKEQL----DALEKETASKLSEMDS 615
N + + S T K ++E ++E+ + L+E L A + S+ ++
Sbjct: 2473 KNAKEFEKEISAT---------KATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQP 2523
Query: 616 FNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALE-QLYKIKRDKLKE 674
N L CG ++Q N L+LK ++ + LE ++ K+K+ +
Sbjct: 2524 SNKPLTCGG-GSGIVQ---------NTKALILK-------SEHIRLEKEISKLKQQNEQL 2566
Query: 675 IERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERK 734
I++K L + L +E WKE K E KQ + K+ K
Sbjct: 2567 IKQKNELLSNNQHLSNEV---------KTWKERTLKREAHKQVTCENSPKSPKVTGTASK 2617
Query: 735 AEE------KQRKDKDTLKAEEKK 752
++ K+R +D + E K
Sbjct: 2618 KKQITPSQCKERNLQDPVPKESPK 2641
Score = 42.0 bits (97), Expect = 0.004
Identities = 88/449 (19%), Positives = 181/449 (40%), Gaps = 64/449 (14%)
Query: 372 ERGNMELEKRRQALMEQQQREAE---RKAQKEKEEWERKQRELQEQEW--KKQLELEKRL 426
+R N +++ ++ L + QQ E K + KE +R E + L+LEK +
Sbjct: 2069 DRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEI 2128
Query: 427 EKQRELERQREEE------RRKDIERREAAKQELERQRRLEWERIR---------RQELL 471
E Q+EL + + + K IE+ A Q + ++++ ++E
Sbjct: 2129 EFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQH 2188
Query: 472 NQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCD 531
N+ + + + K+K L ++++ L S L+D++L + E+L +
Sbjct: 2189 ESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSE 2248
Query: 532 LEIMEI-----------KQLQQELQEYQNKLIYLVPEK---QLLNERIKNMQFSNTPDSG 577
E I K++ Q L+E+ N + K Q N+RI Q +N ++
Sbjct: 2249 SEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRI--CQVNNFFNNR 2306
Query: 578 VSLLHKKSLEKEE----LCQRLKEQLDALEKETASKLSEMDSFNNQLKCG---------- 623
+ + +S E EE + + ++ L +L+++ + L G
Sbjct: 2307 IIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDN 2366
Query: 624 ---NMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRL 680
++ Q + L N KE ++ + +++ ++ D + +++ K
Sbjct: 2367 KNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVH 2426
Query: 681 E---LMQKKK-----LEDEAARKAKQGKENL--WKENLRKEEEEKQKRLQE-EKTQEKIQ 729
E ++K K L+D+ A AK KE + K L K + EK K +E EK +
Sbjct: 2427 ESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATK 2486
Query: 730 EEERKAEEKQRKDKDTLKAEEKKRETASV 758
+E R ++ L+ ++ ++T+ +
Sbjct: 2487 ATVEYQKEVIRLLRENLRRSQQAQDTSVI 2515
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 87.0 bits (214), Expect = 1e-16
Identities = 76/327 (23%), Positives = 140/327 (42%), Gaps = 51/327 (15%)
Query: 909 WTAKKDNHLNFSKHDIITVLE--QQENWWFGEVHGGRGWFPKSYVKIIPGSE-------- 958
+ A D+ L +II ++ Q+E W GE++G RG FP ++VK I
Sbjct: 10 YDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDSLP 69
Query: 959 VKREEPEALYAAVNKKPTSAAYSVG----------------EEYIALYPYSSVEPGDLTF 1002
+KRE + + V + T + G + L+ Y +L
Sbjct: 70 IKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELEL 129
Query: 1003 TEGEEILVTQKDGE-WWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVT 1061
G+ I + ++ E WW+G++ ++ G+FPSN+VK + G ++ + + +A T
Sbjct: 130 KVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEA-QDDSETVLAGPT 188
Query: 1062 SAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSER 1121
S + G+ A G + K G+ G++ G + + +S + P
Sbjct: 189 SPIPSLGNVS-ETASGSVTQPKKIRGIGF--GDIFKEGSVKLRTRTSSSETEEKKPEKPL 245
Query: 1122 ATPAFHPVCQVI------------------AMYDYAANNEDELSFSKGQLINVMNKD--D 1161
+ P Q + ++ Y NEDEL+F +G++I++++K+ +
Sbjct: 246 ILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
Query: 1162 PDWWQGEINGVTGLFPSNYVKMTTDSD 1188
WW+GE+NG G+FP N+ + D
Sbjct: 306 AGWWRGELNGKEGVFPDNFAVQINELD 332
Score = 74.7 bits (182), Expect = 5e-13
Identities = 86/368 (23%), Positives = 150/368 (40%), Gaps = 65/368 (17%)
Query: 759 LVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPS 818
+V+Y Y ++A + DE++ G+II+ + K + E GWL G G G FP N+V+++
Sbjct: 1 MVDYIVEYDYDAVHDDELTIRVGEIIR-NVKKLQEEGWLEGELNGRRGMFPDNFVKEIKR 59
Query: 819 SENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTD-YQNVSFSNLTVNTSWQKKS 877
K S P+ + +V Q +S
Sbjct: 60 ETEFK-------------------DDSLPIKRERHGNVASLVQRIS-------------- 86
Query: 878 AFTRTVSPGSVSPIHGQGQVVENLKAQALC----SWTAKKDNHLNFSKHDIITVLEQ-QE 932
T + G + P H Q + ++ + C + + ++ L DII + E+ +E
Sbjct: 87 --TYGLPAGGIQP-HPQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDINEEVEE 143
Query: 933 NWWFGEVHGGRGWFPKSYVKIIP-GSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYP 991
WW G ++ G FP ++VK + + + E + V PTS S+G ++
Sbjct: 144 GWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGN--VSETA 201
Query: 992 YSSVEP---------GDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESF 1042
SV GD+ F EG L T+ ++ I S + PK Q
Sbjct: 202 SGSVTQPKKIRGIGFGDI-FKEGSVKLRTRTSSSETEEKKPEKPLILQS--LGPKTQSVE 258
Query: 1043 GSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNT--SGWWQGELQARGK 1100
+ + + K E + AY + ++L+ G++I ++ K T +GWW+GEL +
Sbjct: 259 ITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGK-- 316
Query: 1101 KRQKGWFP 1108
+G FP
Sbjct: 317 ---EGVFP 321
Score = 73.2 bits (178), Expect = 1e-12
Identities = 57/210 (27%), Positives = 83/210 (39%), Gaps = 43/210 (20%)
Query: 985 EYIALYPYSSVEPGDLTFTEGEEILVTQKDGE--WWTGSIGDRSGIFPSNYVKP-KDQES 1041
+YI Y Y +V +LT GE I +K E W G + R G+FP N+VK K +
Sbjct: 3 DYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETE 62
Query: 1042 FGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKK 1101
F S + +A + G + P +KK T KK
Sbjct: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKT------------KK 110
Query: 1102 RQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDD 1161
RQ C+V+ ++Y NEDEL G +I++ + +
Sbjct: 111 RQ--------------------------CKVL--FEYIPQNEDELELKVGDIIDINEEVE 142
Query: 1162 PDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
WW G +N GLFPSN+VK +D +
Sbjct: 143 EGWWSGTLNNKLGLFPSNFVKELEVTDDGE 172
Score = 65.5 bits (158), Expect = 3e-10
Identities = 77/361 (21%), Positives = 149/361 (41%), Gaps = 61/361 (16%)
Query: 686 KKLEDEAARKAK-QGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQR---- 740
KKL++E + + G+ ++ +N KE + ++ +++ K + A QR
Sbjct: 30 KKLQEEGWLEGELNGRRGMFPDNFVKEIK-RETEFKDDSLPIKRERHGNVASLVQRISTY 88
Query: 741 ----------KDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKT 790
+K + KKR+ + L+ + +N DE+ GDII ++E+
Sbjct: 89 GLPAGGIQPHPQTKNIKKKTKKRQC-------KVLFEYIPQNEDELELKVGDIIDINEEV 141
Query: 791 VGEPGWLYGSFQGNFGWFPCNYVEKMPSSE----NEKAVSPKKALLPPTVSLSATSTSSE 846
E GW G+ G FP N+V+++ ++ +E + L PT + + SE
Sbjct: 142 --EEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSE 199
Query: 847 PLSSN--QPASVTDYQNVSFSNL----TVNTSWQKKSAFTRTVSPGSVSPIHGQG---QV 897
S + QP + + + F ++ +V + S+ T P + G Q
Sbjct: 200 TASGSVTQPKKI---RGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQS 256
Query: 898 VE--------NLKAQALC----SWTAKKDNHLNFSKHDIITVLEQ---QENWWFGEVHGG 942
VE +KA+ C ++ ++ L F + +II ++ + + WW GE++G
Sbjct: 257 VEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGK 316
Query: 943 RGWFPKSYVKIIPGSEVKREEPEALYAAVNKK---PTSAAYSVGEEYIALYPYSSVEPGD 999
G FP ++ I +E+ ++ P+ K P + ++Y +L P E
Sbjct: 317 EGVFPDNFAVQI--NELDKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKST 374
Query: 1000 L 1000
L
Sbjct: 375 L 375
Score = 56.6 bits (135), Expect = 1e-07
Identities = 32/93 (34%), Positives = 49/93 (52%), Gaps = 10/93 (10%)
Query: 1133 IAMYDYAANNEDELSFSKGQLI-NVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
I YDY A ++DEL+ G++I NV + W +GE+NG G+FP N+VK
Sbjct: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVK--------- 55
Query: 1192 QWCADLQTLDTMQPIERKRQGYIHELIQTEERY 1224
+ + + D PI+R+R G + L+Q Y
Sbjct: 56 EIKRETEFKDDSLPIKRERHGNVASLVQRISTY 88
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 85.1 bits (209), Expect = 4e-16
Identities = 103/439 (23%), Positives = 203/439 (46%), Gaps = 41/439 (9%)
Query: 356 QKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQE 415
Q++L T E K + +++ E E Q+ E R A E+ R+Q +E++
Sbjct: 764 QRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKI-REQLRRKEEQ 822
Query: 416 WKKQLELEKRLE---KQRELE-RQREEERRKDIERREAAKQELERQR--RLEWERIRRQE 469
++K++E++++LE + E+E R + + ++ R A+++L R++ R+ + I
Sbjct: 823 YRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNH 882
Query: 470 LLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQ 529
L QK E + ++NS+ + H E + L+ K+ + + +RL+ T K + + +K+
Sbjct: 883 LSKQKEIEMAQ-KKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKK 941
Query: 530 C--DLEIME---------IKQ----LQQELQEYQNKLIYLVPEKQLLNERIKN-MQFSNT 573
C DL+I++ IKQ L Q + +Y +L L E +LN +++N Q
Sbjct: 942 CFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKER 1001
Query: 574 PDSGVSLLHKK------SLEKEELCQRLKEQLDALEKETASKLSEMDSFN-NQLKCGNMD 626
++ V H + ++ E +R E ++ S+L + +F+ + LK N
Sbjct: 1002 LEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNN-- 1059
Query: 627 DSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYK---IKRDKLKEIERKRLELM 683
+ + Q L S LN+L + R+ + L LE++ K + ++KE+E+K
Sbjct: 1060 EILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQ 1119
Query: 684 QKKKLEDEAARKAKQGKENLWKENL---RKEEEEKQKRLQEEKTQEKIQEEERKAEEK-- 738
K ++ L EN+ ++ ++ K +EKT IQ++ +K
Sbjct: 1120 VKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQ 1179
Query: 739 QRKDKDTLKAEEKKRETAS 757
+K +L EE+ +E S
Sbjct: 1180 AESEKQSLLLEERNKELIS 1198
Score = 71.2 bits (173), Expect = 6e-12
Identities = 106/469 (22%), Positives = 195/469 (41%), Gaps = 72/469 (15%)
Query: 351 QEEEPQKKLPVTFEDKR---KANYERGNMELEKRRQALMEQQQREAERKAQKEK-----E 402
QEEE ++ +E R + E+ E+E ++Q + Q E E + K +
Sbjct: 797 QEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQ 856
Query: 403 EWERKQRELQEQEWKKQLE---LEKRLEKQRELERQREE---------ERRKDIERREAA 450
E QR+L ++ + L+ L L KQ+E+E +++ E KD+ + +
Sbjct: 857 ERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSM 916
Query: 451 KQELERQRRLEWERIRRQELLNQKN-REQEEIVRLNSK--KKNLHLELEALNGKHQQISG 507
QE RLE + I+ Q +K E +IV+ ++ +K + E L Q +G
Sbjct: 917 LQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNG 976
Query: 508 RLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQL--LNERI 565
RL E +L+ + + E ++L+ E++ Y ++L + ++ ++R
Sbjct: 977 RL-------SVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRE 1029
Query: 566 KNMQFSNTPDSGVSLLHKKSLEKEELCQR---LKEQLDALEKETASKLSEMDSFNNQLKC 622
+ F D L K + + L L +QL E + S E + L+
Sbjct: 1030 LELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALRE 1089
Query: 623 GNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKE-IERKRLE 681
+ +Q LS C +KE+ + Y +Q+ + + Y K++ ++E + + + E
Sbjct: 1090 KTLGLERVQKDLSQTQC------QMKEMEQKYQNEQVKVNK-YIGKQESVEERLSQLQSE 1142
Query: 682 LMQKKKLEDEAARKAKQGKENLWKENLRKE----------EEEKQKRLQEEKTQEKIQE- 730
M ++ D+A KA ++ + N++ + E EKQ L EE+ +E I E
Sbjct: 1143 NMLLRQQLDDAHNKADNKEKTV--INIQDQFHAIVQKLQAESEKQSLLLEERNKELISEC 1200
Query: 731 ----------EERKAEEK------QRKDKDTLKAEEKKRETASVLVNYR 763
E KAE + Q++ DTLK + + V YR
Sbjct: 1201 NHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYR 1249
Score = 58.5 bits (140), Expect = 4e-08
Identities = 107/475 (22%), Positives = 202/475 (42%), Gaps = 78/475 (16%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQ-KEK----- 401
++M+++ +++ V ++ + E +L+ L+ QQ +A KA KEK
Sbjct: 1109 KEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENM-LLRQQLDDAHNKADNKEKTVINI 1167
Query: 402 -EEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRL 460
+++ ++LQ + K+ L LE+R K+ E +ER+ E +A ++ + RQ +
Sbjct: 1168 QDQFHAIVQKLQAESEKQSLLLEER-NKELISECNHLKERQYQYENEKAEREVVVRQLQQ 1226
Query: 461 EWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQD--------V 512
E +++ +++ + E R+N L E + L K QI +LQ+ V
Sbjct: 1227 ELADTLKKQSMSEASLEVTSRYRIN-----LEDETQDLKKKLGQIRNQLQEAQDRHTEAV 1281
Query: 513 RLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSN 572
R ++ Q + ++ L++ KQ+ + ++E Q L+ + + K M+
Sbjct: 1282 RCAEKMQDHKQKLEKDNAKLKVTVKKQMDK-IEELQKNLLNANLSEDEKEQLKKLMELKQ 1340
Query: 573 TPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMD----SFNNQLKCGN---- 624
+ + + KK++E E K L K T KL+E + SF+ LK
Sbjct: 1341 SLECNLDQEMKKNVELEREITGFKNLL----KMTRKKLNEYENGEFSFHGDLKTSQFEMD 1396
Query: 625 ---------MDDSVLQCLLSLLSCLN--NLFLLLKELRETYNTQQLALEQLYKIKRDKLK 673
+DD + + CL+ +L+E + T Q E+L K K+ +
Sbjct: 1397 IQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQ 1456
Query: 674 E-------IERKRLELMQKKKLEDEAARKAKQ------------------GKENL--WKE 706
E IER +EL Q K+ + E +A+Q +ENL ++E
Sbjct: 1457 EVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRE 1516
Query: 707 N----LRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETAS 757
N ++ + E + K L+ E ++ K +E+ E + K K E K R++ S
Sbjct: 1517 NNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELE-KYKQLYLEELKVRKSLS 1570
Score = 58.2 bits (139), Expect = 5e-08
Identities = 86/425 (20%), Positives = 183/425 (43%), Gaps = 39/425 (9%)
Query: 349 KMQEEEPQKKLPVTFEDKRKANYERGNMELE-KRRQALMEQQQREAERKAQKEKEEWERK 407
K Q +E +KK FED + + +++ K+ + + Q + + E
Sbjct: 932 KNQNQEKEKKC---FEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAML 988
Query: 408 QRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRR 467
+L+ ++ K+ RLE + E R D ++ E +K+ELE L ++R R
Sbjct: 989 NSKLENEKQSKE-----RLEAEVESYHSRLAAAIHDRDQSETSKRELE----LAFQRAR- 1038
Query: 468 QELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLD 527
E +++ ++ L + L +L K + R + + LE +
Sbjct: 1039 DECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQ 1098
Query: 528 KQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTP-DSGVSLLHKKSL 586
K ++K+++Q+ Q Q K+ + +++ + ER+ +Q N + H K+
Sbjct: 1099 KDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKAD 1158
Query: 587 EKEELCQRLKEQLDA----LEKETASKLSEMDSFNNQL--KCGNMDDSVLQCLLSLLSCL 640
KE+ +++Q A L+ E+ + ++ N +L +C ++ + Q
Sbjct: 1159 NKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAERE 1218
Query: 641 NNLFLLLKELRETYNTQQLALEQL-----YKIK-RDKLKEIERK----RLELMQKKKLED 690
+ L +EL +T Q ++ L Y+I D+ +++++K R +L + +
Sbjct: 1219 VVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHT 1278
Query: 691 EAAR---KAKQGKENLWKENLR-----KEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKD 742
EA R K + K+ L K+N + K++ +K + LQ+ + E+E++ +K +
Sbjct: 1279 EAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMEL 1338
Query: 743 KDTLK 747
K +L+
Sbjct: 1339 KQSLE 1343
Score = 37.0 bits (84), Expect = 0.12
Identities = 89/438 (20%), Positives = 173/438 (39%), Gaps = 55/438 (12%)
Query: 330 SFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQ 389
+F+ K D+ N +P M+ E L T E K + G M+ + +A +
Sbjct: 468 NFKMAKLEDTRNVGMP-VAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAA--EH 524
Query: 390 QREAERKAQKEKEEWERKQRELQEQEWK---KQLELEKRLEKQRELERQREEERRKDIER 446
E + ++E+E E Q +++E+ K ++E+ + + + +++ I++
Sbjct: 525 DLEVASEEEQEREGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQK 584
Query: 447 REAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLEL--EALNGKHQQ 504
R++ + + ++ R E +E + Q + V+ K+K E + GK
Sbjct: 585 RKSGETDHQQFPRKE-----NKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASL 639
Query: 505 ISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNER 564
++G L V + L +D+ E K+ E + +N++ Q +++
Sbjct: 640 LTGGLLQV-----DDDSSLSEIDED---EGRPTKKTSNEKNKVKNQI-------QSMDDV 684
Query: 565 IKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGN 624
Q S T L H L EQL K++ S L
Sbjct: 685 DDLTQSSETASEDCELPHSSYKN----FMLLIEQLGMECKDSVSLLK------------- 727
Query: 625 MDDSVLQCLLSLLSCLNNLFLL---LKELRETYNTQQLALEQLYKIKRD---KLKEIERK 678
+ D+ L C L N+ LL +K++ + N Q L + +IK + E ER+
Sbjct: 728 IQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERE 787
Query: 679 RLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEK 738
L E+E R A E + ++ RKEE+ + +E + +++++ + E +
Sbjct: 788 LCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYR----KEVEVKQQLELSLQTLEME 843
Query: 739 QRKDKDTLKAEEKKRETA 756
R K L ++R A
Sbjct: 844 LRTVKSNLNQVVQERNDA 861
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 84.7 bits (208), Expect = 5e-16
Identities = 91/348 (26%), Positives = 176/348 (50%), Gaps = 25/348 (7%)
Query: 411 LQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQEL 470
LQE+E + QL + L+ R+ E QR RR+ IE R+ + L QR E E +R+
Sbjct: 543 LQEKEEQHQLAVTAYLKNSRK-EHQRILARRQTIEERKERLESLNIQREKE-ELEQREAE 600
Query: 471 LNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQC 530
L + + +EE +R +K++ E E + +H+QI + RL+ Q +KTEL +
Sbjct: 601 LQKVRKAEEERLRQEAKER----EKERILQEHEQIKKKTVRERLE-QIKKTELGAKAFK- 654
Query: 531 DLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEE 590
D++I ++++L + ++ L EK+ L ER+KN + L + L K
Sbjct: 655 DIDIEDLEELDPDFI-MAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSA 713
Query: 591 LCQRLKEQLDALEKETASKLSEMDSFNNQ-LKCGNMDDSVLQCLLSLLSCLNNLFLL-LK 648
++ + +D E++ +++ M + L+ N +L+ +LF++ LK
Sbjct: 714 YEEQRIKDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLED--------RDLFVMRLK 765
Query: 649 ELRETYNTQQLAL--EQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKE 706
R++ ++L E+L + + ++L+E +R+R E + ++ + ++ +E + KE
Sbjct: 766 AARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKE 825
Query: 707 NLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKD-TLKAEEKKR 753
+EE E+ +R + E+ + QE +K EE +RK + L+ EE++R
Sbjct: 826 ---REERERAERAKREEELREYQERVKKLEEVERKKRQRELEIEERER 870
Score = 82.8 bits (203), Expect = 2e-15
Identities = 97/406 (23%), Positives = 183/406 (45%), Gaps = 62/406 (15%)
Query: 350 MQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQR 409
+QE+E Q +L VT K N + + + RRQ + E+++R Q+EKEE E+++
Sbjct: 543 LQEKEEQHQLAVTAYLK---NSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREA 599
Query: 410 ELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQE 469
ELQ+ ++ E++R + +E E+ + ++ E K++ R+R E+I++ E
Sbjct: 600 ELQK---------VRKAEEERLRQEAKEREKERILQEHEQIKKKTVRER---LEQIKKTE 647
Query: 470 LLNQKNREQEEIVRLNSKK-KNLHLE-LEALNGKHQQISGRLQDVRLKKQTQKTELEVLD 527
L +K K++ +E LE L+ D + KQ ++ E
Sbjct: 648 --------------LGAKAFKDIDIEDLEELD----------PDFIMAKQVEQLE----- 678
Query: 528 KQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLE 587
E K+LQ+ L+ + K+ Y K+L + + + L ++ E
Sbjct: 679 -------KEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEE 731
Query: 588 KEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLL 647
+ Q +E+ + + L + D F +LK SV + L
Sbjct: 732 RITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAAR--QSVYE---EKLKQFEERLAEE 786
Query: 648 KELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKE-NLWKE 706
+ R +Q E+ R+K +E +R+ E M K++ E E A +AK+ +E ++E
Sbjct: 787 RHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQE 846
Query: 707 NLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKK 752
++K EE ++K+ Q E +I+E ER+ EE++R +L ++ +
Sbjct: 847 RVKKLEEVERKKRQREL---EIEERERRREEERRLGDSSLSRKDSR 889
Score = 76.3 bits (186), Expect = 2e-13
Identities = 94/412 (22%), Positives = 186/412 (45%), Gaps = 47/412 (11%)
Query: 345 PSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEW 404
P Q M E+ + +L KA +E+ K L E++++ K
Sbjct: 509 PHLQSMPSEQIRNQLTAMSSVLAKA------LEVIKPAHILQEKEEQHQLAVTAYLKNSR 562
Query: 405 ERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWER 464
+ QR L ++ +E+R E+ L QRE+E ++E+REA EL++ R+ E ER
Sbjct: 563 KEHQRILARRQ-----TIEERKERLESLNIQREKE---ELEQREA---ELQKVRKAEEER 611
Query: 465 IRRQELLNQKNREQEEIVRLNS--KKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTE 522
+R++ K RE+E I++ + KKK + LE + K + + +D+ ++ +
Sbjct: 612 LRQEA----KEREKERILQEHEQIKKKTVRERLEQIK-KTELGAKAFKDIDIEDLEELDP 666
Query: 523 LEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLH 582
++ KQ + E K+LQ+ L+ + K+ Y K+L + + + L
Sbjct: 667 DFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWE 726
Query: 583 KKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNN 642
++ E+ Q +E+ + + L + D F +LK SV +
Sbjct: 727 QQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQ--SVYE----------- 773
Query: 643 LFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKEN 702
LK+ E +LA E+ +++ K + E +R+ ++K+ E++ + + KE
Sbjct: 774 --EKLKQFEE-----RLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKER 826
Query: 703 LWKENL-RKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKR 753
+E R + EE+ + QE +K++E ERK +++ + ++ + E++R
Sbjct: 827 EERERAERAKREEELREYQER--VKKLEEVERKKRQRELEIEERERRREEER 876
Score = 54.3 bits (129), Expect = 7e-07
Identities = 41/126 (32%), Positives = 67/126 (53%), Gaps = 11/126 (8%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRR----QALMEQQQREAERKAQKEKEE 403
Q + EE+ ++ E++ ER E+RR + E++QR AE + KE+EE
Sbjct: 769 QSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREE 828
Query: 404 WERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWE 463
ER +R +E+E ++ E K+LE+ +RQRE E IE RE ++E +RRL
Sbjct: 829 RERAERAKREEELREYQERVKKLEEVERKKRQRELE----IEERERRREE---ERRLGDS 881
Query: 464 RIRRQE 469
+ R++
Sbjct: 882 SLSRKD 887
Score = 53.5 bits (127), Expect = 1e-06
Identities = 82/428 (19%), Positives = 179/428 (41%), Gaps = 76/428 (17%)
Query: 344 LPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEE 403
L S +E+E ++ + RKA ER E ++R + + Q+ + ++K +E+ E
Sbjct: 582 LESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLE 641
Query: 404 WERKQRELQEQEWK-------KQLELEKRLEKQRELERQREEERRKDIERREAAKQELER 456
+ K+ EL + +K ++L+ + + KQ E + ++E ++ ++ +E ER
Sbjct: 642 -QIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFER 700
Query: 457 QRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKK 516
+RLE E+ K+ +E+ ++ +++ + ++ +Q R K
Sbjct: 701 AKRLE-------EIPLIKSAYEEQRIK----------DMDLWEQQEEERITTMQLEREKA 743
Query: 517 QTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNE---RIKNMQFSNT 573
K + + + DL +M +K +Q + E + K E++L E R++ +
Sbjct: 744 LEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQF----EERLAEERHNRLEERKRQRK 799
Query: 574 PDSGVSLLHKKSLEKEELC--QRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQ 631
+ ++ +K E++ Q LKE+ + E A + E+ + ++K
Sbjct: 800 EERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVK---------- 849
Query: 632 CLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDE 691
L+E+ ++L +E+ R++ +E ER+ + L +
Sbjct: 850 --------------KLEEVERKKRQRELEIEE-----RERRREEERR----LGDSSLSRK 886
Query: 692 AARKAKQGKENLWKENLRKEEE------EKQKRLQEEKTQEKIQEEERKAEEKQRKDKDT 745
+R + E W++ + E EK+ R E + +++ R+ EE+ R+ D
Sbjct: 887 DSRWGDRDSEGTWRKGPEADSEWRRGPPEKEWRRGEGRDEDR---SHRRDEERPRRLGDD 943
Query: 746 LKAEEKKR 753
E R
Sbjct: 944 EDREPSLR 951
Score = 37.4 bits (85), Expect = 0.090
Identities = 23/73 (31%), Positives = 39/73 (53%), Gaps = 11/73 (15%)
Query: 395 RKAQKEKEE-W--ERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAK 451
R+ +K +EE W R+ R +E+EW + EK+R+ + Q EE KD ER +
Sbjct: 1179 REKEKAREESWGPPRESRPSEEREWDR--------EKERDRDNQDREENDKDPERERDRE 1230
Query: 452 QELERQRRLEWER 464
++++R+ R R
Sbjct: 1231 RDVDREDRFRRPR 1243
Score = 32.0 bits (71), Expect = 3.8
Identities = 13/55 (23%), Positives = 31/55 (56%), Gaps = 4/55 (7%)
Query: 704 WKENLRKEEEE----KQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRE 754
W+E + EE ++ R EE+ ++ +E +R ++++ DKD + +++R+
Sbjct: 1178 WREKEKAREESWGPPRESRPSEEREWDREKERDRDNQDREENDKDPERERDRERD 1232
Score = 32.0 bits (71), Expect = 3.8
Identities = 35/179 (19%), Positives = 79/179 (44%), Gaps = 9/179 (5%)
Query: 346 SYQKMQEEEPQKKLPVTFEDKR-KANYERGNMELEKRRQALMEQQ-QREAERKAQKEKEE 403
S+ +E P ++ E +R + N +R + + R+ E+ RE + +++
Sbjct: 1188 SWGPPRESRPSEEREWDREKERDRDNQDREENDKDPERERDRERDVDREDRFRRPRDEGG 1247
Query: 404 WERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWE 463
W R E + W+ + +R ++ R+ R+ ++RR ERR+ +R RR
Sbjct: 1248 WRRGPAE-ESSSWR---DSSRRDDRDRDDRRRERDDRRDLRERRDLRD---DRDRRGPPL 1300
Query: 464 RIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTE 522
R R+E+ + + + + R+ + + AL+ ++ R ++ +K + + E
Sbjct: 1301 RSEREEVSSWRRADDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAE 1359
Score = 31.2 bits (69), Expect = 6.5
Identities = 23/111 (20%), Positives = 50/111 (45%), Gaps = 4/111 (3%)
Query: 380 KRRQALMEQQQREAERKAQKEKEEWER-KQRELQEQEWKKQLELEKRLEKQRELERQREE 438
+ ++ E+ E+ EW+R K+R+ Q+ + E +K E++R+ ER +
Sbjct: 1179 REKEKAREESWGPPRESRPSEEREWDREKERDRDNQD---REENDKDPERERDRERDVDR 1235
Query: 439 ERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKK 489
E R R E + + W R++ ++ +R +E R + +++
Sbjct: 1236 EDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRER 1286
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 84.7 bits (208), Expect = 5e-16
Identities = 86/329 (26%), Positives = 161/329 (48%), Gaps = 40/329 (12%)
Query: 323 PPELVPPSFRGGKQID-SINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELE-- 379
P P + GG D ++ T P Q ++ +K E +R+ R E E
Sbjct: 690 PTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEER 749
Query: 380 KRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLE-LEKRLEKQRELERQREE 438
KR++ L +QQ E R+ Q+E ERK+RE +E +KQ E L ++ E++ L RQREE
Sbjct: 750 KRQEEL-RRQQEEILRRQQEE----ERKRREEEELARRKQEEALRRQREQEIALRRQREE 804
Query: 439 ERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNRE------QEEIVRLNSKKKNLH 492
E R +++E A + LE +RR E ER +++ELL ++ E +EE + ++ L
Sbjct: 805 EER---QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLR 861
Query: 493 LELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLI 552
+E EA +H++ + +++ +++Q + L +Q + +++LQQ+ Q+ Q
Sbjct: 862 MEEEAARLRHEEEERKRKELEVQRQKE------LMRQRQQQQEALRRLQQQQQQQQ---- 911
Query: 553 YLVPEKQLLNERIKNMQFSNT---PDSGVSLLHKKSLE-------KEELCQRLKEQLDAL 602
+ + +L + Q + T + +SL + LE +EE ++ +E + AL
Sbjct: 912 --LAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKAL 969
Query: 603 EKETASKLSEMDSFNNQLKCGNMDDSVLQ 631
+++ + ++ + N K S+L+
Sbjct: 970 QQQQQQQQQKLSGWGNVSKPSGTTKSLLE 998
Score = 79.0 bits (193), Expect = 3e-14
Identities = 81/314 (25%), Positives = 143/314 (45%), Gaps = 44/314 (14%)
Query: 349 KMQEEEPQKKLPVTFEDKRKANYERGNMELEK--RRQALMEQQQREAERKAQKEKEEWER 406
K+++E + ++ E++ + E + E+ RRQ E+++RE E A++++EE R
Sbjct: 730 KLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALR 789
Query: 407 KQRELQEQEWKKQLELEKRLEKQREL----ERQREEERRKDIE------RREAAK---QE 453
+QRE QE ++Q E E+R +++ L ER+REEE R+ E EAAK +E
Sbjct: 790 RQRE-QEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREE 848
Query: 454 LERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHL----ELEALNGKHQQISGRL 509
E QRRLE R+R +E + E+EE K+K L + EL + Q+ RL
Sbjct: 849 EEAQRRLEENRLRMEEEAARLRHEEEE-----RKRKELEVQRQKELMRQRQQQQEALRRL 903
Query: 510 QDVRLKKQT------------QKTELEVLDKQCDLEIMEIKQLQQEL-------QEYQNK 550
Q + ++Q Q++ Q L + EI++L++E Q Q +
Sbjct: 904 QQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQR 963
Query: 551 LIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKL 610
+ ++Q ++ K + N + +++EE Q K+Q + + ++
Sbjct: 964 ELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRA 1023
Query: 611 SEMDSFNNQLKCGN 624
N GN
Sbjct: 1024 RNNTHSNLHTSIGN 1037
Score = 58.9 bits (141), Expect = 3e-08
Identities = 77/335 (22%), Positives = 149/335 (44%), Gaps = 78/335 (23%)
Query: 410 ELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQE 469
+LQ+ E K +LE+ ++ E+ +REEE RK ++EL RQ+ E +RRQ+
Sbjct: 719 QLQQLEKAKAAKLEQE-RREAEMRAKREEEERK-------RQEELRRQQE---EILRRQQ 767
Query: 470 LLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQ 529
+K RE+EE+ R + EAL + +Q ++ L++Q ++ E + ++
Sbjct: 768 EEERKRREEEELARRKQE--------EALRRQREQ------EIALRRQREEEERQQQEEA 813
Query: 530 CDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKE 589
L +E ++ ++E + Q +L+ E+ K + E+E
Sbjct: 814 --LRRLEERRREEEERRKQEELLRKQEEEAA----------------------KWAREEE 849
Query: 590 ELCQRLKEQLDALEKETAS-KLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLK 648
E +RL+E +E+E A + E + +L+ K
Sbjct: 850 EAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ----------------------K 887
Query: 649 ELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENL 708
EL QQ AL +L + ++ + + +++L ++ A Q + L +
Sbjct: 888 ELMRQRQQQQEALRRLQQQQQQQ----QLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 943
Query: 709 RKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDK 743
+K EEE++++L+EE Q + Q E KA ++Q++ +
Sbjct: 944 QKLEEERERQLREE--QRRQQRELMKALQQQQQQQ 976
Score = 57.4 bits (137), Expect = 8e-08
Identities = 34/109 (31%), Positives = 65/109 (59%), Gaps = 15/109 (13%)
Query: 660 ALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRL 719
ALEQL ++++ K ++E++R E + K E+E RK ++ +E LR+++EE++KR
Sbjct: 716 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEE-RKRQEELRRQQEEILRRQQEEERKRR 774
Query: 720 QEEKTQEKIQEE--------------ERKAEEKQRKDKDTLKAEEKKRE 754
+EE+ + QEE +R+ EE+Q++++ + EE++RE
Sbjct: 775 EEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE 823
Score = 46.6 bits (109), Expect = 1e-04
Identities = 31/111 (27%), Positives = 67/111 (60%), Gaps = 9/111 (8%)
Query: 645 LLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLW 704
+ L+ RE QQ E L +++ + +E ER++ E + +K+ E+EAA+ A++
Sbjct: 796 IALRRQREEEERQQQE-EALRRLEERRREEEERRKQEELLRKQ-EEEAAKWARE------ 847
Query: 705 KENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-RKDKDTLKAEEKKRE 754
+E ++ EE + R++EE + + +EEERK +E + ++ K+ ++ ++++E
Sbjct: 848 EEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQE 898
Score = 43.9 bits (102), Expect = 0.001
Identities = 30/111 (27%), Positives = 58/111 (52%), Gaps = 5/111 (4%)
Query: 648 KELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQ--GKENLWK 705
+E E ++L +Q ++R + +E +R+ E + ++K E+ R+ +Q +
Sbjct: 744 REEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQRE 803
Query: 706 ENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETA 756
E R+++EE +RL+E + +E EE RK EE RK ++ ++ E A
Sbjct: 804 EEERQQQEEALRRLEERRREE---EERRKQEELLRKQEEEAAKWAREEEEA 851
Score = 40.8 bits (94), Expect = 0.008
Identities = 42/169 (24%), Positives = 84/169 (49%), Gaps = 10/169 (5%)
Query: 597 EQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNT 656
EQL LEK A+KL E + +++ ++ + L +E R+
Sbjct: 718 EQLQQLEKAKAAKL-EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 776
Query: 657 QQLAL-EQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGK-----ENLWKENLRK 710
++LA +Q ++R + +EI +R ++++ ++EA R+ ++ + +E LRK
Sbjct: 777 EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 836
Query: 711 EEEEKQK-RLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASV 758
+EEE K +EE+ Q +++E + EE+ + + + EE+KR+ V
Sbjct: 837 QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRH--EEEERKRKELEV 883
Score = 35.0 bits (79), Expect = 0.45
Identities = 50/238 (21%), Positives = 104/238 (43%), Gaps = 25/238 (10%)
Query: 507 GRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIK 566
G + D+ L T LE L + LE + +L+QE +E + + E++ E ++
Sbjct: 701 GSVWDLPLDTTTPGPALEQLQQ---LEKAKAAKLEQERREAEMRA-KREEEERKRQEELR 756
Query: 567 NMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQL--DALEKETASKLSEMDSFNNQLKCGN 624
Q +K E+EEL +R +E+ E+E A + + Q +
Sbjct: 757 RQQEEILRRQQEE--ERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQE--- 811
Query: 625 MDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQ 684
L L +E E ++L +Q + + +E E +R
Sbjct: 812 -------------EALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEEN 858
Query: 685 KKKLEDEAARKAKQGKENLWKE-NLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
+ ++E+EAAR + +E KE +++++E ++R Q+++ ++Q+++++ + Q K
Sbjct: 859 RLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK 916
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 84.7 bits (208), Expect = 5e-16
Identities = 86/329 (26%), Positives = 161/329 (48%), Gaps = 40/329 (12%)
Query: 323 PPELVPPSFRGGKQID-SINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELE-- 379
P P + GG D ++ T P Q ++ +K E +R+ R E E
Sbjct: 717 PTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEER 776
Query: 380 KRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLE-LEKRLEKQRELERQREE 438
KR++ L +QQ E R+ Q+E ERK+RE +E +KQ E L ++ E++ L RQREE
Sbjct: 777 KRQEEL-RRQQEEILRRQQEE----ERKRREEEELARRKQEEALRRQREQEIALRRQREE 831
Query: 439 ERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNRE------QEEIVRLNSKKKNLH 492
E R +++E A + LE +RR E ER +++ELL ++ E +EE + ++ L
Sbjct: 832 EER---QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLR 888
Query: 493 LELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLI 552
+E EA +H++ + +++ +++Q + L +Q + +++LQQ+ Q+ Q
Sbjct: 889 MEEEAARLRHEEEERKRKELEVQRQKE------LMRQRQQQQEALRRLQQQQQQQQ---- 938
Query: 553 YLVPEKQLLNERIKNMQFSNT---PDSGVSLLHKKSLE-------KEELCQRLKEQLDAL 602
+ + +L + Q + T + +SL + LE +EE ++ +E + AL
Sbjct: 939 --LAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKAL 996
Query: 603 EKETASKLSEMDSFNNQLKCGNMDDSVLQ 631
+++ + ++ + N K S+L+
Sbjct: 997 QQQQQQQQQKLSGWGNVSKPSGTTKSLLE 1025
Score = 79.0 bits (193), Expect = 3e-14
Identities = 81/314 (25%), Positives = 143/314 (45%), Gaps = 44/314 (14%)
Query: 349 KMQEEEPQKKLPVTFEDKRKANYERGNMELEK--RRQALMEQQQREAERKAQKEKEEWER 406
K+++E + ++ E++ + E + E+ RRQ E+++RE E A++++EE R
Sbjct: 757 KLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALR 816
Query: 407 KQRELQEQEWKKQLELEKRLEKQREL----ERQREEERRKDIE------RREAAK---QE 453
+QRE QE ++Q E E+R +++ L ER+REEE R+ E EAAK +E
Sbjct: 817 RQRE-QEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREE 875
Query: 454 LERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHL----ELEALNGKHQQISGRL 509
E QRRLE R+R +E + E+EE K+K L + EL + Q+ RL
Sbjct: 876 EEAQRRLEENRLRMEEEAARLRHEEEE-----RKRKELEVQRQKELMRQRQQQQEALRRL 930
Query: 510 QDVRLKKQT------------QKTELEVLDKQCDLEIMEIKQLQQEL-------QEYQNK 550
Q + ++Q Q++ Q L + EI++L++E Q Q +
Sbjct: 931 QQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQR 990
Query: 551 LIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKL 610
+ ++Q ++ K + N + +++EE Q K+Q + + ++
Sbjct: 991 ELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRA 1050
Query: 611 SEMDSFNNQLKCGN 624
N GN
Sbjct: 1051 RNNTHSNLHTSIGN 1064
Score = 58.9 bits (141), Expect = 3e-08
Identities = 77/335 (22%), Positives = 149/335 (44%), Gaps = 78/335 (23%)
Query: 410 ELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQE 469
+LQ+ E K +LE+ ++ E+ +REEE RK ++EL RQ+ E +RRQ+
Sbjct: 746 QLQQLEKAKAAKLEQE-RREAEMRAKREEEERK-------RQEELRRQQE---EILRRQQ 794
Query: 470 LLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQ 529
+K RE+EE+ R + EAL + +Q ++ L++Q ++ E + ++
Sbjct: 795 EEERKRREEEELARRKQE--------EALRRQREQ------EIALRRQREEEERQQQEEA 840
Query: 530 CDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKE 589
L +E ++ ++E + Q +L+ E+ K + E+E
Sbjct: 841 --LRRLEERRREEEERRKQEELLRKQEEEAA----------------------KWAREEE 876
Query: 590 ELCQRLKEQLDALEKETAS-KLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLK 648
E +RL+E +E+E A + E + +L+ K
Sbjct: 877 EAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ----------------------K 914
Query: 649 ELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENL 708
EL QQ AL +L + ++ + + +++L ++ A Q + L +
Sbjct: 915 ELMRQRQQQQEALRRLQQQQQQQ----QLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 970
Query: 709 RKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDK 743
+K EEE++++L+EE Q + Q E KA ++Q++ +
Sbjct: 971 QKLEEERERQLREE--QRRQQRELMKALQQQQQQQ 1003
Score = 57.4 bits (137), Expect = 8e-08
Identities = 34/109 (31%), Positives = 65/109 (59%), Gaps = 15/109 (13%)
Query: 660 ALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRL 719
ALEQL ++++ K ++E++R E + K E+E RK ++ +E LR+++EE++KR
Sbjct: 743 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEE-RKRQEELRRQQEEILRRQQEEERKRR 801
Query: 720 QEEKTQEKIQEE--------------ERKAEEKQRKDKDTLKAEEKKRE 754
+EE+ + QEE +R+ EE+Q++++ + EE++RE
Sbjct: 802 EEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE 850
Score = 46.6 bits (109), Expect = 1e-04
Identities = 31/111 (27%), Positives = 67/111 (60%), Gaps = 9/111 (8%)
Query: 645 LLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLW 704
+ L+ RE QQ E L +++ + +E ER++ E + +K+ E+EAA+ A++
Sbjct: 823 IALRRQREEEERQQQE-EALRRLEERRREEEERRKQEELLRKQ-EEEAAKWARE------ 874
Query: 705 KENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-RKDKDTLKAEEKKRE 754
+E ++ EE + R++EE + + +EEERK +E + ++ K+ ++ ++++E
Sbjct: 875 EEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQE 925
Score = 43.9 bits (102), Expect = 0.001
Identities = 30/111 (27%), Positives = 58/111 (52%), Gaps = 5/111 (4%)
Query: 648 KELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQ--GKENLWK 705
+E E ++L +Q ++R + +E +R+ E + ++K E+ R+ +Q +
Sbjct: 771 REEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQRE 830
Query: 706 ENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETA 756
E R+++EE +RL+E + +E EE RK EE RK ++ ++ E A
Sbjct: 831 EEERQQQEEALRRLEERRREE---EERRKQEELLRKQEEEAAKWAREEEEA 878
Score = 40.8 bits (94), Expect = 0.008
Identities = 42/169 (24%), Positives = 84/169 (49%), Gaps = 10/169 (5%)
Query: 597 EQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNT 656
EQL LEK A+KL E + +++ ++ + L +E R+
Sbjct: 745 EQLQQLEKAKAAKL-EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 803
Query: 657 QQLAL-EQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGK-----ENLWKENLRK 710
++LA +Q ++R + +EI +R ++++ ++EA R+ ++ + +E LRK
Sbjct: 804 EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 863
Query: 711 EEEEKQK-RLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASV 758
+EEE K +EE+ Q +++E + EE+ + + + EE+KR+ V
Sbjct: 864 QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRH--EEEERKRKELEV 910
Score = 35.0 bits (79), Expect = 0.45
Identities = 50/238 (21%), Positives = 104/238 (43%), Gaps = 25/238 (10%)
Query: 507 GRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIK 566
G + D+ L T LE L + LE + +L+QE +E + + E++ E ++
Sbjct: 728 GSVWDLPLDTTTPGPALEQLQQ---LEKAKAAKLEQERREAEMRA-KREEEERKRQEELR 783
Query: 567 NMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQL--DALEKETASKLSEMDSFNNQLKCGN 624
Q +K E+EEL +R +E+ E+E A + + Q +
Sbjct: 784 RQQEEILRRQQEE--ERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQE--- 838
Query: 625 MDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQ 684
L L +E E ++L +Q + + +E E +R
Sbjct: 839 -------------EALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEEN 885
Query: 685 KKKLEDEAARKAKQGKENLWKE-NLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
+ ++E+EAAR + +E KE +++++E ++R Q+++ ++Q+++++ + Q K
Sbjct: 886 RLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK 943
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 84.7 bits (208), Expect = 5e-16
Identities = 86/329 (26%), Positives = 161/329 (48%), Gaps = 40/329 (12%)
Query: 323 PPELVPPSFRGGKQID-SINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELE-- 379
P P + GG D ++ T P Q ++ +K E +R+ R E E
Sbjct: 696 PTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEER 755
Query: 380 KRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLE-LEKRLEKQRELERQREE 438
KR++ L +QQ E R+ Q+E ERK+RE +E +KQ E L ++ E++ L RQREE
Sbjct: 756 KRQEEL-RRQQEEILRRQQEE----ERKRREEEELARRKQEEALRRQREQEIALRRQREE 810
Query: 439 ERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNRE------QEEIVRLNSKKKNLH 492
E R +++E A + LE +RR E ER +++ELL ++ E +EE + ++ L
Sbjct: 811 EER---QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLR 867
Query: 493 LELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLI 552
+E EA +H++ + +++ +++Q + L +Q + +++LQQ+ Q+ Q
Sbjct: 868 MEEEAARLRHEEEERKRKELEVQRQKE------LMRQRQQQQEALRRLQQQQQQQQ---- 917
Query: 553 YLVPEKQLLNERIKNMQFSNT---PDSGVSLLHKKSLE-------KEELCQRLKEQLDAL 602
+ + +L + Q + T + +SL + LE +EE ++ +E + AL
Sbjct: 918 --LAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKAL 975
Query: 603 EKETASKLSEMDSFNNQLKCGNMDDSVLQ 631
+++ + ++ + N K S+L+
Sbjct: 976 QQQQQQQQQKLSGWGNVSKPSGTTKSLLE 1004
Score = 79.0 bits (193), Expect = 3e-14
Identities = 81/314 (25%), Positives = 143/314 (45%), Gaps = 44/314 (14%)
Query: 349 KMQEEEPQKKLPVTFEDKRKANYERGNMELEK--RRQALMEQQQREAERKAQKEKEEWER 406
K+++E + ++ E++ + E + E+ RRQ E+++RE E A++++EE R
Sbjct: 736 KLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALR 795
Query: 407 KQRELQEQEWKKQLELEKRLEKQREL----ERQREEERRKDIE------RREAAK---QE 453
+QRE QE ++Q E E+R +++ L ER+REEE R+ E EAAK +E
Sbjct: 796 RQRE-QEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREE 854
Query: 454 LERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHL----ELEALNGKHQQISGRL 509
E QRRLE R+R +E + E+EE K+K L + EL + Q+ RL
Sbjct: 855 EEAQRRLEENRLRMEEEAARLRHEEEE-----RKRKELEVQRQKELMRQRQQQQEALRRL 909
Query: 510 QDVRLKKQT------------QKTELEVLDKQCDLEIMEIKQLQQEL-------QEYQNK 550
Q + ++Q Q++ Q L + EI++L++E Q Q +
Sbjct: 910 QQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQR 969
Query: 551 LIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKL 610
+ ++Q ++ K + N + +++EE Q K+Q + + ++
Sbjct: 970 ELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRA 1029
Query: 611 SEMDSFNNQLKCGN 624
N GN
Sbjct: 1030 RNNTHSNLHTSIGN 1043
Score = 58.9 bits (141), Expect = 3e-08
Identities = 77/335 (22%), Positives = 149/335 (44%), Gaps = 78/335 (23%)
Query: 410 ELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQE 469
+LQ+ E K +LE+ ++ E+ +REEE RK ++EL RQ+ E +RRQ+
Sbjct: 725 QLQQLEKAKAAKLEQE-RREAEMRAKREEEERK-------RQEELRRQQE---EILRRQQ 773
Query: 470 LLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQ 529
+K RE+EE+ R + EAL + +Q ++ L++Q ++ E + ++
Sbjct: 774 EEERKRREEEELARRKQE--------EALRRQREQ------EIALRRQREEEERQQQEEA 819
Query: 530 CDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKE 589
L +E ++ ++E + Q +L+ E+ K + E+E
Sbjct: 820 --LRRLEERRREEEERRKQEELLRKQEEEAA----------------------KWAREEE 855
Query: 590 ELCQRLKEQLDALEKETAS-KLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLK 648
E +RL+E +E+E A + E + +L+ K
Sbjct: 856 EAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ----------------------K 893
Query: 649 ELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENL 708
EL QQ AL +L + ++ + + +++L ++ A Q + L +
Sbjct: 894 ELMRQRQQQQEALRRLQQQQQQQ----QLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 949
Query: 709 RKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDK 743
+K EEE++++L+EE Q + Q E KA ++Q++ +
Sbjct: 950 QKLEEERERQLREE--QRRQQRELMKALQQQQQQQ 982
Score = 57.4 bits (137), Expect = 8e-08
Identities = 34/109 (31%), Positives = 65/109 (59%), Gaps = 15/109 (13%)
Query: 660 ALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRL 719
ALEQL ++++ K ++E++R E + K E+E RK ++ +E LR+++EE++KR
Sbjct: 722 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEE-RKRQEELRRQQEEILRRQQEEERKRR 780
Query: 720 QEEKTQEKIQEE--------------ERKAEEKQRKDKDTLKAEEKKRE 754
+EE+ + QEE +R+ EE+Q++++ + EE++RE
Sbjct: 781 EEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE 829
Score = 46.6 bits (109), Expect = 1e-04
Identities = 31/111 (27%), Positives = 67/111 (60%), Gaps = 9/111 (8%)
Query: 645 LLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLW 704
+ L+ RE QQ E L +++ + +E ER++ E + +K+ E+EAA+ A++
Sbjct: 802 IALRRQREEEERQQQE-EALRRLEERRREEEERRKQEELLRKQ-EEEAAKWARE------ 853
Query: 705 KENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-RKDKDTLKAEEKKRE 754
+E ++ EE + R++EE + + +EEERK +E + ++ K+ ++ ++++E
Sbjct: 854 EEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQE 904
Score = 43.9 bits (102), Expect = 0.001
Identities = 30/111 (27%), Positives = 58/111 (52%), Gaps = 5/111 (4%)
Query: 648 KELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQ--GKENLWK 705
+E E ++L +Q ++R + +E +R+ E + ++K E+ R+ +Q +
Sbjct: 750 REEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQRE 809
Query: 706 ENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETA 756
E R+++EE +RL+E + +E EE RK EE RK ++ ++ E A
Sbjct: 810 EEERQQQEEALRRLEERRREE---EERRKQEELLRKQEEEAAKWAREEEEA 857
Score = 40.8 bits (94), Expect = 0.008
Identities = 42/169 (24%), Positives = 84/169 (49%), Gaps = 10/169 (5%)
Query: 597 EQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNT 656
EQL LEK A+KL E + +++ ++ + L +E R+
Sbjct: 724 EQLQQLEKAKAAKL-EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 782
Query: 657 QQLAL-EQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGK-----ENLWKENLRK 710
++LA +Q ++R + +EI +R ++++ ++EA R+ ++ + +E LRK
Sbjct: 783 EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 842
Query: 711 EEEEKQK-RLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASV 758
+EEE K +EE+ Q +++E + EE+ + + + EE+KR+ V
Sbjct: 843 QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRH--EEEERKRKELEV 889
Score = 35.0 bits (79), Expect = 0.45
Identities = 50/238 (21%), Positives = 104/238 (43%), Gaps = 25/238 (10%)
Query: 507 GRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIK 566
G + D+ L T LE L + LE + +L+QE +E + + E++ E ++
Sbjct: 707 GSVWDLPLDTTTPGPALEQLQQ---LEKAKAAKLEQERREAEMRA-KREEEERKRQEELR 762
Query: 567 NMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQL--DALEKETASKLSEMDSFNNQLKCGN 624
Q +K E+EEL +R +E+ E+E A + + Q +
Sbjct: 763 RQQEEILRRQQEE--ERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQE--- 817
Query: 625 MDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQ 684
L L +E E ++L +Q + + +E E +R
Sbjct: 818 -------------EALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEEN 864
Query: 685 KKKLEDEAARKAKQGKENLWKE-NLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
+ ++E+EAAR + +E KE +++++E ++R Q+++ ++Q+++++ + Q K
Sbjct: 865 RLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK 922
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,782,191
Number of Sequences: 37866
Number of extensions: 2591749
Number of successful extensions: 72907
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1156
Number of HSP's successfully gapped in prelim test: 1523
Number of HSP's that attempted gapping in prelim test: 16829
Number of HSP's gapped (non-prelim): 22148
length of query: 1249
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1135
effective length of database: 13,930,794
effective search space: 15811451190
effective search space used: 15811451190
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.