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Search of human proteins with 193804850
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|193804850 dehydrogenase/reductase (SDR family) X-linked
[Homo sapiens]
(330 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo... 660 0.0
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 202 4e-52
gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo... 202 4e-52
gi|186928839 retinol dehydrogenase 12 [Homo sapiens] 199 2e-51
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 191 6e-49
gi|19923931 retinol dehydrogenase 13 isoform 2 [Homo sapiens] 172 5e-43
gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo s... 164 1e-40
gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Hom... 138 6e-33
gi|72534732 dehydrogenase/reductase (SDR family) member 12 isofo... 78 1e-14
gi|13375997 dehydrogenase/reductase (SDR family) member 12 isofo... 78 1e-14
gi|7705421 hydroxysteroid (17-beta) dehydrogenase 7 [Homo sapiens] 65 8e-11
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 63 4e-10
gi|4502599 carbonyl reductase 1 [Homo sapiens] 60 2e-09
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 59 5e-09
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 58 1e-08
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 57 2e-08
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 57 2e-08
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 56 4e-08
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 56 5e-08
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo... 55 9e-08
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 54 3e-07
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 52 7e-07
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 52 7e-07
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 52 7e-07
gi|4502601 carbonyl reductase 3 [Homo sapiens] 52 1e-06
gi|40254992 carbonic reductase 4 [Homo sapiens] 50 4e-06
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform... 49 5e-06
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens] 49 5e-06
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo... 49 5e-06
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom... 49 5e-06
>gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo
sapiens]
Length = 330
Score = 660 bits (1704), Expect = 0.0
Identities = 330/330 (100%), Positives = 330/330 (100%)
Query: 1 MSPLSAARAALRVYAVGAAVILAQLLRRCRGGFLEPVFPPRPDRVAIVTGGTDGIGYSTA 60
MSPLSAARAALRVYAVGAAVILAQLLRRCRGGFLEPVFPPRPDRVAIVTGGTDGIGYSTA
Sbjct: 1 MSPLSAARAALRVYAVGAAVILAQLLRRCRGGFLEPVFPPRPDRVAIVTGGTDGIGYSTA 60
Query: 61 KHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDLASMTSIRQFVQKFKMKK 120
KHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDLASMTSIRQFVQKFKMKK
Sbjct: 61 KHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDLASMTSIRQFVQKFKMKK 120
Query: 121 IPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLLDTLKESGSPGHSARVVT 180
IPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLLDTLKESGSPGHSARVVT
Sbjct: 121 IPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLLDTLKESGSPGHSARVVT 180
Query: 181 VSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYHLQRLLAAEGSHVTANVVDP 240
VSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYHLQRLLAAEGSHVTANVVDP
Sbjct: 181 VSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYHLQRLLAAEGSHVTANVVDP 240
Query: 241 GVVNTDVYKHVFWATRLAKKLLGWLLFKTPDEGAWTSIYAAVTPELEGVGGHYLYNEKET 300
GVVNTDVYKHVFWATRLAKKLLGWLLFKTPDEGAWTSIYAAVTPELEGVGGHYLYNEKET
Sbjct: 241 GVVNTDVYKHVFWATRLAKKLLGWLLFKTPDEGAWTSIYAAVTPELEGVGGHYLYNEKET 300
Query: 301 KSLHVTYNQKLQQQLWSKSCEMTGVLDVTL 330
KSLHVTYNQKLQQQLWSKSCEMTGVLDVTL
Sbjct: 301 KSLHVTYNQKLQQQLWSKSCEMTGVLDVTL 330
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 202 bits (513), Expect = 4e-52
Identities = 128/324 (39%), Positives = 177/324 (54%), Gaps = 11/324 (3%)
Query: 7 ARAALRVYAVGAAVILAQLLRRCRGGFLEPVFPPRPDRVAIVTGGTDGIGYSTAKHLARL 66
+R L + A+G A LL+ G P P + IVTG GIG TA LAR
Sbjct: 2 SRYLLPLSALGTVAGAAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARR 61
Query: 67 GMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDLASMTSIRQFVQKFKMKKIPLHVL 126
G ++I+A + K + I+ ETLN V + DLAS+ SIR+F K ++ + +L
Sbjct: 62 GGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDIL 121
Query: 127 INNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLLDTLKESGSPGHSARVVTVSSATH 186
INNAGVM P T DGFE FG+N+LGHFLLTNLLLD LK S +R++ +SS H
Sbjct: 122 INNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASA----PSRIINLSSLAH 177
Query: 187 YVAELNMDDLQ-SSACYSPHAAYAQSKLALVLFTYHLQRLLAAEGSHVTANVVDPGVVNT 245
++ DDL + Y+ AAY QSKLA+VLFT L R L +GS VT N + PGV T
Sbjct: 178 VAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKELSRRL--QGSGVTVNALHPGVART 235
Query: 246 DVYKHV-FWATRLAKKLLG---WLLFKTPDEGAWTSIYAAVTPELEGVGGHYLYNEKETK 301
++ +H + + LG WLL K+P+ A S Y AV EL V G Y K+
Sbjct: 236 ELGRHTGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKA 295
Query: 302 SLHVTYNQKLQQQLWSKSCEMTGV 325
++++ ++LW++S + G+
Sbjct: 296 PAPEAEDEEVARRLWAESARLVGL 319
>gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo
sapiens]
Length = 336
Score = 202 bits (513), Expect = 4e-52
Identities = 130/345 (37%), Positives = 191/345 (55%), Gaps = 32/345 (9%)
Query: 4 LSAARAALRVYAVGAAVILA-------QLLRRCRGGFLEPVFPPRPDRVAIVTGGTDGIG 56
++ A AA + A+G A+ LA ++ R RGG +P + ++TG G+G
Sbjct: 1 MAVATAAAVLAALGGALWLAARRFVGPRVQRLRRGG--DPGL--MHGKTVLITGANSGLG 56
Query: 57 YSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLN-------------DKVEFLYCDL 103
+TA L RLG VI+ + ++A++ +++ E ++ DL
Sbjct: 57 RATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDL 116
Query: 104 ASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLL 163
AS+ S+R F Q+ ++ L VLINNAG+ P KT DGFE FG+N+LGHFLLTNLLL
Sbjct: 117 ASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLL 176
Query: 164 DTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYHLQ 223
LK S +R+V VSS + ++N DDL S Y+ Y++SKLA +LFT L
Sbjct: 177 GLLKSSA----PSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELA 232
Query: 224 RLLAAEGSHVTANVVDPGVVNTDVYKHVF--WATRLAKKLLGWLLFKTPDEGAWTSIYAA 281
R L EG++VT NV+ PG+V T++ +H+ + L+ W FKTP EGA TSIY A
Sbjct: 233 RRL--EGTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLA 290
Query: 282 VTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKSCEMTGVL 326
+PE+EGV G Y + KE + L ++ + ++LW S M G+L
Sbjct: 291 SSPEVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMVGLL 335
>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
Length = 316
Score = 199 bits (507), Expect = 2e-51
Identities = 123/288 (42%), Positives = 163/288 (56%), Gaps = 16/288 (5%)
Query: 42 PDRVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYC 101
P +V ++TG GIG TA+ LA G V IA + K + S+I+ +T N +V
Sbjct: 38 PGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKL 97
Query: 102 DLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNL 161
DL+ SIR F + F ++ LH+LINNAGVMM P KT DGFE H G+N+LGHFLLT L
Sbjct: 98 DLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYL 157
Query: 162 LLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYH 221
LL+ LK S ARVV VSS H++ ++ DLQS YS AY SKLA VLFT
Sbjct: 158 LLERLKVSA----PARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRE 213
Query: 222 LQRLLAAEGSHVTANVVDPGVVNTDVYKHVFWATRLAKKLLGWLLF----KTPDEGAWTS 277
L + L +G+ VT V PGVV +++ +H + L W LF KT EGA TS
Sbjct: 214 LAKRL--QGTGVTTYAVHPGVVRSELVRH------SSLLCLLWRLFSPFVKTAREGAQTS 265
Query: 278 IYAAVTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKSCEMTGV 325
++ A+ LE + G Y + K T N K ++LW+ SCE+ G+
Sbjct: 266 LHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGI 313
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 191 bits (486), Expect = 6e-49
Identities = 115/287 (40%), Positives = 164/287 (57%), Gaps = 14/287 (4%)
Query: 42 PDRVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYC 101
P +V +VTG GIG TAK LA+ G V +A + K + V +I+ T N +V
Sbjct: 40 PGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKL 99
Query: 102 DLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNL 161
DL+ SIR F + F ++ LHVLINNAGVMM P KT DGFE H G+N+LGHFLLT+L
Sbjct: 100 DLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHL 159
Query: 162 LLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYH 221
LL+ LKES +R+V VSS H++ ++ +LQ Y+ AY SKLA +LFT
Sbjct: 160 LLEKLKESA----PSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQE 215
Query: 222 LQRLLAAEGSHVTANVVDPGVVNTDVYKHVFWATRLAKKLLGWL---LFKTPDEGAWTSI 278
L R L +GS VT V PG V +++ +H + + + WL KTP +GA TS+
Sbjct: 216 LARRL--KGSGVTTYSVHPGTVQSELVRHSSF-----MRWMWWLFSFFIKTPQQGAQTSL 268
Query: 279 YAAVTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKSCEMTGV 325
+ A+T LE + G++ + N+ + ++LW SC++ G+
Sbjct: 269 HCALTEGLEILSGNHFSDCHVAWVSAQARNETIARRLWDVSCDLLGL 315
>gi|19923931 retinol dehydrogenase 13 isoform 2 [Homo sapiens]
Length = 260
Score = 172 bits (435), Expect = 5e-43
Identities = 103/252 (40%), Positives = 143/252 (56%), Gaps = 11/252 (4%)
Query: 79 KAKQVVSKIKEETLNDKVEFLYCDLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQR 138
K + I+ ETLN V + DLAS+ SIR+F K ++ + +LINNAGVM P
Sbjct: 3 KCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHW 62
Query: 139 KTRDGFEEHFGLNYLGHFLLTNLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQ- 197
T DGFE FG+N+LGHFLLTNLLLD LK S +R++ +SS H ++ DDL
Sbjct: 63 TTEDGFEMQFGVNHLGHFLLTNLLLDKLKASA----PSRIINLSSLAHVAGHIDFDDLNW 118
Query: 198 SSACYSPHAAYAQSKLALVLFTYHLQRLLAAEGSHVTANVVDPGVVNTDVYKHV-FWATR 256
+ Y+ AAY QSKLA+VLFT L R L +GS VT N + PGV T++ +H +
Sbjct: 119 QTRKYNTKAAYCQSKLAIVLFTKELSRRL--QGSGVTVNALHPGVARTELGRHTGIHGST 176
Query: 257 LAKKLLG---WLLFKTPDEGAWTSIYAAVTPELEGVGGHYLYNEKETKSLHVTYNQKLQQ 313
+ LG WLL K+P+ A S Y AV EL V G Y K+ ++++ +
Sbjct: 177 FSSTTLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVAR 236
Query: 314 QLWSKSCEMTGV 325
+LW++S + G+
Sbjct: 237 RLWAESARLVGL 248
>gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo
sapiens]
Length = 414
Score = 164 bits (414), Expect = 1e-40
Identities = 110/296 (37%), Positives = 154/296 (52%), Gaps = 27/296 (9%)
Query: 44 RVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDL 103
+V +VTG GIG+ TAK A G HVI+A N ++A + VS+I EE KVE + DL
Sbjct: 125 KVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAMTLDL 184
Query: 104 ASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLL 163
A + S++ F + FK K +PLHVL+ NA +P T+DG E F +N+LGHF L LL
Sbjct: 185 ALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQ 244
Query: 164 DTLKESGSPGHSARVVTVSSATHYVAELN--MDDLQSSAC------YSPHAAYAQSKLAL 215
D L S ARV+ VSS +H ++N + L S Y AY +SKL
Sbjct: 245 DVLCRSA----PARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCN 300
Query: 216 VLFTYHLQRLLAAEGSHVTANVVDPGVVNTDVYKHVFWATRLAKKLLGWLLFKTPDEGAW 275
+LF+ L R L+ G VT+N V PG + +W L L K+ +GA
Sbjct: 301 ILFSNELHRRLSPRG--VTSNAVHPGNMMYSNIHRSWWVYTLL-FTLARPFTKSMQQGAA 357
Query: 276 TSIYAAVTPELEGVGGHYLYN------------EKETKSLHVTYNQKLQQQLWSKS 319
T++Y A PELEG+GG Y N E+ ++L + +Q++L S+S
Sbjct: 358 TTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQS 413
>gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Homo
sapiens]
Length = 377
Score = 138 bits (348), Expect = 6e-33
Identities = 96/285 (33%), Positives = 143/285 (50%), Gaps = 11/285 (3%)
Query: 44 RVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDL 103
R A+VTG GIG TA LAR G V++A + + + +++E+ N++V F+ DL
Sbjct: 37 RTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDL 96
Query: 104 ASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLL 163
AS+ S+R F F + L +LI+NAG+ +TR+ F +N++G FLLT+LLL
Sbjct: 97 ASLASVRAFATAFLSSEPRLDILIHNAGISSC--GRTREAFNLLLRVNHIGPFLLTHLLL 154
Query: 164 DTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSAC--YSPHAAYAQSKLALVLFTYH 221
LK +RVV V+SA H L+ L AYA +KLA VLF
Sbjct: 155 PCLKACA----PSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAYADTKLANVLFARE 210
Query: 222 LQRLLAAEGSHVTANVVDPGVVNTDVY-KHVFWATRLAKKLLGWLLFKTPDEGAWTSIYA 280
L L A G VT PG VN++++ +HV R + L WL+ + P GA T +Y
Sbjct: 211 LANQLEATG--VTCYAAHPGPVNSELFLRHVPGWLRPLLRPLAWLVLRAPRGGAQTPLYC 268
Query: 281 AVTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKSCEMTGV 325
A+ +E + G Y N + + + +LW S + G+
Sbjct: 269 ALQEGIEPLSGRYFANCHVEEVPPAARDDRAAHRLWEASKRLAGL 313
>gi|72534732 dehydrogenase/reductase (SDR family) member 12 isoform
1 [Homo sapiens]
Length = 271
Score = 77.8 bits (190), Expect = 1e-14
Identities = 56/142 (39%), Positives = 78/142 (54%), Gaps = 12/142 (8%)
Query: 80 AKQVVSKIKEETLNDKVEFLYC-DLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQR 138
AKQ+ K E + FL+ DL+ I +FV+ FK + LHVLINNAG M+ +
Sbjct: 32 AKQLPLKSPSENI-----FLHIVDLSDPKQIWKFVENFKQEH-KLHVLINNAGCMVNKRE 85
Query: 139 KTRDGFEEHFGLNYLGHFLLTNLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQS 198
T DG E++F N LG ++LT L+ L++ H RV+TVSS V +LN +DLQS
Sbjct: 86 LTEDGLEKNFAANTLGVYILTTGLIPVLEKE----HDPRVITVSSGGMLVQKLNTNDLQS 141
Query: 199 SAC-YSPHAAYAQSKLALVLFT 219
+ YAQ+K V+ T
Sbjct: 142 ERTPFDGTMVYAQNKRQQVVLT 163
>gi|13375997 dehydrogenase/reductase (SDR family) member 12 isoform
2 [Homo sapiens]
Length = 242
Score = 77.8 bits (190), Expect = 1e-14
Identities = 56/142 (39%), Positives = 78/142 (54%), Gaps = 12/142 (8%)
Query: 80 AKQVVSKIKEETLNDKVEFLYC-DLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQR 138
AKQ+ K E + FL+ DL+ I +FV+ FK + LHVLINNAG M+ +
Sbjct: 32 AKQLPLKSPSENI-----FLHIVDLSDPKQIWKFVENFKQEH-KLHVLINNAGCMVNKRE 85
Query: 139 KTRDGFEEHFGLNYLGHFLLTNLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQS 198
T DG E++F N LG ++LT L+ L++ H RV+TVSS V +LN +DLQS
Sbjct: 86 LTEDGLEKNFAANTLGVYILTTGLIPVLEKE----HDPRVITVSSGGMLVQKLNTNDLQS 141
Query: 199 SAC-YSPHAAYAQSKLALVLFT 219
+ YAQ+K V+ T
Sbjct: 142 ERTPFDGTMVYAQNKRQQVVLT 163
>gi|7705421 hydroxysteroid (17-beta) dehydrogenase 7 [Homo sapiens]
Length = 341
Score = 65.1 bits (157), Expect = 8e-11
Identities = 59/236 (25%), Positives = 103/236 (43%), Gaps = 40/236 (16%)
Query: 44 RVAIVTGGTDGIGYSTAKHLARLG--MHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYC 101
+V ++TG + GIG + K L +H+ +A N SKA+ V + + +V +
Sbjct: 3 KVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQV 62
Query: 102 DLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQ------------------------ 137
D++++ S+ + ++ K + L + NAG+M PQ
Sbjct: 63 DVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTAEG 122
Query: 138 ------RKTRDGFEEHFGLNYLGHFLLTNLLLDTLKESGSPGHSARVVTVSSATHYVAEL 191
+ T DG +E F N GHF+L L L S +P ++++ SS + +
Sbjct: 123 LLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNP---SQLIWTSSRSARKSNF 179
Query: 192 NMDDLQSSACYSPHAAYAQSKLALVLFTYHLQRLLAAEGSHVTANVVDPGVVNTDV 247
+++D Q S P Y+ SK A L + L R +G + +NV PG T++
Sbjct: 180 SLEDFQHSKGKEP---YSSSKYATDLLSVALNRNFNQQGLY--SNVACPGTALTNL 230
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 62.8 bits (151), Expect = 4e-10
Identities = 49/206 (23%), Positives = 91/206 (44%), Gaps = 16/206 (7%)
Query: 43 DRVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCD 102
DR+A+VTG + GIG + A+ L + G+ V+ +++ ++ K + CD
Sbjct: 11 DRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCD 70
Query: 103 LASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQ--RKTRDGFEEHFGLNYLGHFLLTN 160
L++ I + + + + INNAG+ + G+++ F +N L + T
Sbjct: 71 LSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTR 130
Query: 161 LLLDTLKESG-SPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFT 219
++KE GH + ++S H V L++ Y+ +K A+ T
Sbjct: 131 EAYQSMKERNVDDGHIININSMSG--HRVLPLSVTHF-----------YSATKYAVTALT 177
Query: 220 YHLQRLLAAEGSHVTANVVDPGVVNT 245
L++ L +H+ A + PGVV T
Sbjct: 178 EGLRQELREAQTHIRATCISPGVVET 203
>gi|4502599 carbonyl reductase 1 [Homo sapiens]
Length = 277
Score = 60.5 bits (145), Expect = 2e-09
Identities = 69/284 (24%), Positives = 123/284 (43%), Gaps = 47/284 (16%)
Query: 45 VAIVTGGTDGIGYSTAKHLARL-GMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFL-YCD 102
VA+VTGG GIG + + L RL V++ + ++ + V +++ E L+ + L D
Sbjct: 7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDD 66
Query: 103 LASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGL--NYLGHFLLTN 160
L S+ ++R F++K + L VL+NNAG+ T + + N+ G +
Sbjct: 67 LQSIRALRDFLRK---EYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCT 123
Query: 161 LLLDTLKESGSPGHSARVVTVSSATHYVAELN--------------------MDDLQSSA 200
LL +K G + + +++V + EL ++D +
Sbjct: 124 ELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGV 183
Query: 201 CYS---PHAAYAQSKLAL-VLFTYHLQRLL-AAEGSHVTANVVDPGVVNTDVYKHVFWAT 255
P +AY +K+ + VL H ++L +G + N PG V TD
Sbjct: 184 HQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTD--------- 234
Query: 256 RLAKKLLGWLLFKTPDEGAWTSIY-AAVTPELEGVGGHYLYNEK 298
+ G K+P+EGA T +Y A + P+ EG G ++ ++
Sbjct: 235 -----MAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKR 273
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 59.3 bits (142), Expect = 5e-09
Identities = 55/209 (26%), Positives = 83/209 (39%), Gaps = 21/209 (10%)
Query: 44 RVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDL 103
+VA+VTG GIG + A+ L G V + N Q + + E+ K F+ CD+
Sbjct: 6 KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDV 65
Query: 104 ASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLL 163
A +R +K L +L+NNAGV +E+ +N + T L L
Sbjct: 66 ADQQQLRDTFRKVVDHFGRLDILVNNAGV------NNEKNWEKTLQINLVSVISGTYLGL 119
Query: 164 DTL-KESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYHL 222
D + K++G G +NM L + Y SK +V FT
Sbjct: 120 DYMSKQNGGEGGII--------------INMSSLAGLMPVAQQPVYCASKHGIVGFTRSA 165
Query: 223 QRLLAAEGSHVTANVVDPGVVNTDVYKHV 251
S V N + PG VNT + + +
Sbjct: 166 ALAANLMNSGVRLNAICPGFVNTAILESI 194
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 58.2 bits (139), Expect = 1e-08
Identities = 59/209 (28%), Positives = 93/209 (44%), Gaps = 21/209 (10%)
Query: 45 VAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDLA 104
+ ++TG GIG TA A+L +++ N ++ +K K L KV D +
Sbjct: 38 IVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCK--GLGAKVHTFVVDCS 95
Query: 105 SMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQR-KTRD-GFEEHFGLNYLGHFLLTNLL 162
+ I +K K + + +L+NNAGV+ T+D E+ F +N L HF T
Sbjct: 96 NREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAF 155
Query: 163 LDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYHL 222
L + ++ + GH +VTV+SA +V+ + AY SK A V F L
Sbjct: 156 LPAMTKN-NHGH---IVTVASAAGHVSVPFL------------LAYCSSKFAAVGFHKTL 199
Query: 223 -QRLLAAEGSHVTANVVDPGVVNTDVYKH 250
L A + + V + P VNT K+
Sbjct: 200 TDELAALQITGVKTTCLCPNFVNTGFIKN 228
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 57.4 bits (137), Expect = 2e-08
Identities = 60/215 (27%), Positives = 94/215 (43%), Gaps = 30/215 (13%)
Query: 43 DRVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCD 102
+RVA+VTG T GIG++ A+ LAR G HV+I+ + ++K++ E L+ V + C
Sbjct: 36 NRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLS--VAGIVCH 93
Query: 103 LASMTSIRQFVQKFKMKKIPLHVLINNAGVMMV---PQRKTRDGFEEHFGLNYLGHFLLT 159
+ Q V K + L+ +AGV + + +++ +N LL
Sbjct: 94 VGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLL 153
Query: 160 NLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAA---YAQSKLALV 216
+ LL ++ V+ VSS A Y+P A Y SK AL+
Sbjct: 154 SQLLPYME-----NRRGAVILVSSI---------------AAYNPVVALGVYNVSKTALL 193
Query: 217 LFTYHLQRLLAAEGSHVTANVVDPGVVNTDVYKHV 251
T L LA + + N V PG++ TD K V
Sbjct: 194 GLTRTLALELAPK--DIRVNCVVPGIIKTDFSKVV 226
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 57.0 bits (136), Expect = 2e-08
Identities = 59/213 (27%), Positives = 93/213 (43%), Gaps = 30/213 (14%)
Query: 43 DRVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCD 102
+RVA+VTG T GIG++ A+ LAR G HV+I+ + ++K++ E L+ V + C
Sbjct: 36 NRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLS--VAGIVCH 93
Query: 103 LASMTSIRQFVQKFKMKKIPLHVLINNAGVMMV---PQRKTRDGFEEHFGLNYLGHFLLT 159
+ Q V K + L+ +AGV + + +++ +N LL
Sbjct: 94 VGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLL 153
Query: 160 NLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAA---YAQSKLALV 216
+ LL ++ V+ VSS A Y+P A Y SK AL+
Sbjct: 154 SQLLPYME-----NRRGAVILVSSI---------------AAYNPVVALGVYNVSKTALL 193
Query: 217 LFTYHLQRLLAAEGSHVTANVVDPGVVNTDVYK 249
T L LA + + N V PG++ TD K
Sbjct: 194 GLTRTLALELAPK--DIRVNCVVPGIIKTDFSK 224
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 56.2 bits (134), Expect = 4e-08
Identities = 54/213 (25%), Positives = 91/213 (42%), Gaps = 32/213 (15%)
Query: 44 RVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDL 103
+V +VTGG GIG + G V+I ++S + + E+ L V F+ CD+
Sbjct: 10 KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRAL-----EQELPGAV-FILCDV 63
Query: 104 ASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQR---KTRDGFEEHFGLNYLGHFLLTN 160
++ V + + L ++NNAG PQR + GF + LN LG + LT
Sbjct: 64 TQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTK 123
Query: 161 LLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTY 220
L L L++S V+ +SS + + + Y +K A+ T
Sbjct: 124 LALPYLRKS-----QGNVINISSLVGAIGQ------------AQAVPYVATKGAVTAMT- 165
Query: 221 HLQRLLAAEGS--HVTANVVDPGVVNTDVYKHV 251
+ LA + S V N + PG + T +++ +
Sbjct: 166 ---KALALDESPYGVRVNCISPGNIWTPLWEEL 195
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 55.8 bits (133), Expect = 5e-08
Identities = 54/217 (24%), Positives = 95/217 (43%), Gaps = 24/217 (11%)
Query: 40 PRPDRVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFL 99
P ++VA+VT TDGIG++ A+ LA+ G HV+++ Q V+ ++ E L+ V
Sbjct: 29 PLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLS--VTGT 86
Query: 100 YCDLASMTSIRQFVQKFKMKKIPLHVLINNAGV---MMVPQRKTRDGFEEHFGLNYLGHF 156
C + + V + +L++NA V T + +++ +N
Sbjct: 87 VCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPA 146
Query: 157 LLTNLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALV 216
L+T ++ +++ G VV VSS + S +SP Y SK AL+
Sbjct: 147 LMTKAVVPEMEKRG----GGSVVIVSSIAAF---------SPSPGFSP---YNVSKTALL 190
Query: 217 LFTYHLQRLLAAEGSHVTANVVDPGVVNTDVYKHVFW 253
T L LA ++ N + PG++ T + + W
Sbjct: 191 GLTKTLAIELAPR--NIRVNCLAPGLIKTS-FSRMLW 224
>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
sapiens]
Length = 330
Score = 55.1 bits (131), Expect = 9e-08
Identities = 55/197 (27%), Positives = 93/197 (47%), Gaps = 28/197 (14%)
Query: 44 RVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDL 103
R A+V+G TDGIG + A+ LA G+++I+ N+ K QVV+K +T + + + D
Sbjct: 68 RWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKL-QVVAKDIADTYKVETDIIVADF 126
Query: 104 ASMTSIRQFVQKFKMKKIPLHVLINNAGVMM-VPQRKTR---DGFEEHFGLNYLGHFLLT 159
+S I +++ +K + +L+NN GV PQ T+ D + +N L+
Sbjct: 127 SSGREIYLPIRE-ALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMV 185
Query: 160 NLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPH---AAYAQSKLALV 216
+++L + E +VT+S S +C P AA++ SK L
Sbjct: 186 HVVLPGMVER----KKGAIVTIS---------------SGSCCKPTPQLAAFSASKAYLD 226
Query: 217 LFTYHLQRLLAAEGSHV 233
F+ LQ A++G V
Sbjct: 227 HFSRALQYEYASKGIFV 243
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 53.5 bits (127), Expect = 3e-07
Identities = 43/161 (26%), Positives = 72/161 (44%), Gaps = 17/161 (10%)
Query: 34 LEPVFPPRPDRV----AIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKE 89
+ P+ P+P + +VTGG+ GIG A + G + + N+ K Q +I+
Sbjct: 19 VSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEM 78
Query: 90 ETLNDKVEFLYCDL---ASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRD---- 142
++NDK L + + +++ + K P+ +L+N AG M K D
Sbjct: 79 HSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAG--MAVSGKFEDLEVS 136
Query: 143 GFEEHFGLNYLGHFLLTNLLLDTLKESGSPGHSARVVTVSS 183
FE +NYLG + ++ T+KE R+V VSS
Sbjct: 137 TFERLMSINYLGSVYPSRAVITTMKER----RVGRIVFVSS 173
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 52.0 bits (123), Expect = 7e-07
Identities = 52/202 (25%), Positives = 86/202 (42%), Gaps = 20/202 (9%)
Query: 47 IVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDLASM 106
IVTG + GIG A HLA++G HV++ + ++VVS E ++ + M
Sbjct: 38 IVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGA-ASAHYIAGTMEDM 96
Query: 107 TSIRQFVQKFKMKKIPLHVLINN--AGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLLD 164
T QFV + L +LI N + + +N+L + +LT L
Sbjct: 97 TFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP 156
Query: 165 TLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYHLQR 224
LK+S + +V VSS L Y AAY+ SK AL F +++
Sbjct: 157 MLKQS-----NGSIVVVSS------------LAGKVAYPMVAAYSASKFALDGFFSSIRK 199
Query: 225 LLAAEGSHVTANVVDPGVVNTD 246
+ +V+ + G+++T+
Sbjct: 200 EYSVSRVNVSITLCVLGLIDTE 221
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 52.0 bits (123), Expect = 7e-07
Identities = 52/202 (25%), Positives = 86/202 (42%), Gaps = 20/202 (9%)
Query: 47 IVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDLASM 106
IVTG + GIG A HLA++G HV++ + ++VVS E ++ + M
Sbjct: 38 IVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGA-ASAHYIAGTMEDM 96
Query: 107 TSIRQFVQKFKMKKIPLHVLINN--AGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLLD 164
T QFV + L +LI N + + +N+L + +LT L
Sbjct: 97 TFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP 156
Query: 165 TLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYHLQR 224
LK+S + +V VSS L Y AAY+ SK AL F +++
Sbjct: 157 MLKQS-----NGSIVVVSS------------LAGKVAYPMVAAYSASKFALDGFFSSIRK 199
Query: 225 LLAAEGSHVTANVVDPGVVNTD 246
+ +V+ + G+++T+
Sbjct: 200 EYSVSRVNVSITLCVLGLIDTE 221
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 52.0 bits (123), Expect = 7e-07
Identities = 47/141 (33%), Positives = 64/141 (45%), Gaps = 20/141 (14%)
Query: 5 SAARAALRVYAVGAAVILAQLLR---------RCRGGFLEPVFPPRPDRVAIVTGGTDGI 55
SA AA +Y VGA + LR R G E P A+VTG TDGI
Sbjct: 3 SALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTDGI 62
Query: 56 GYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKE----ETLNDKVEFLYCDLASMTSIRQ 111
G S A+ LA+ GM V++ + K QV S+IKE ET V+F D+
Sbjct: 63 GKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKI---- 118
Query: 112 FVQKFKMKKIPLHVLINNAGV 132
K + + + +L+NN G+
Sbjct: 119 ---KTGLAGLEIGILVNNVGM 136
>gi|4502601 carbonyl reductase 3 [Homo sapiens]
Length = 277
Score = 51.6 bits (122), Expect = 1e-06
Identities = 68/276 (24%), Positives = 111/276 (40%), Gaps = 58/276 (21%)
Query: 44 RVAIVTGGTDGIGYSTAKHLAR-LGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFL-YC 101
RVA+VTG GIG + A+ L R V++ + ++ + V +++ E L+ + L
Sbjct: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65
Query: 102 DLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGL--NYLGHFLLT 159
DL S+ ++R F++K + L+VL+NNA V + L N+ +
Sbjct: 66 DLQSIRALRDFLRK---EYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122
Query: 160 NLLLDTLKESGSPGHSARVVTVSSA------------------THYVAELNMDDLQSSAC 201
N LL +K G RVV +SS + + E ++ DL
Sbjct: 123 NELLPIMKPHG------RVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFV 176
Query: 202 YS-----------PHAAYAQSKLALVLFTYHLQRLL--AAEGSHVTANVVDPGVVNTDVY 248
P++ Y SKL + + + L R L + + N PG V TD
Sbjct: 177 EDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD-- 234
Query: 249 KHVFWATRLAKKLLGWLLFKTPDEGAWTSIYAAVTP 284
+ G +T +EGA T +Y A+ P
Sbjct: 235 ------------MDGKDSIRTVEEGAETPVYLALLP 258
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 49.7 bits (117), Expect = 4e-06
Identities = 52/210 (24%), Positives = 87/210 (41%), Gaps = 27/210 (12%)
Query: 43 DRVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCD 102
D+V V GG+ GIG + A+ +AR G + + N AK + + L CD
Sbjct: 2 DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHL-----AFSCD 56
Query: 103 LASMTSIRQFVQKFKMKKIPLHVLINNAGVM---MVPQRKTRDGFEEHFGLNYLGHFLLT 159
+A ++ ++ + ++ L+N AG+ ++ + KT D N LG L
Sbjct: 57 VAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTED-MVSQLHTNLLGSMLTC 115
Query: 160 NLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFT 219
+ T+ + +V V S S + Y+ SK LV F+
Sbjct: 116 KAAMRTMIQQ----QGGSIVNVGSIVGLKGN------------SGQSVYSASKGGLVGFS 159
Query: 220 YHLQRLLAAEGSHVTANVVDPGVVNTDVYK 249
L + +A + + NVV PG V+TD+ K
Sbjct: 160 RALAKEVARK--KIRVNVVAPGFVHTDMTK 187
>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
[Homo sapiens]
Length = 178
Score = 49.3 bits (116), Expect = 5e-06
Identities = 47/177 (26%), Positives = 71/177 (40%), Gaps = 21/177 (11%)
Query: 44 RVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDL 103
+VA+VTG GIG + A+ L G V + N Q + + E+ K F+ CD+
Sbjct: 6 KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDV 65
Query: 104 ASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLL 163
A +R +K L +L+NNAGV +E+ +N + T L L
Sbjct: 66 ADQQQLRDTFRKVVDHFGRLDILVNNAGV------NNEKNWEKTLQINLVSVISGTYLGL 119
Query: 164 DTL-KESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFT 219
D + K++G G +NM L + Y SK +V FT
Sbjct: 120 DYMSKQNGGEGGII--------------INMSSLAGLMPVAQQPVYCASKHGIVGFT 162
>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
Length = 387
Score = 49.3 bits (116), Expect = 5e-06
Identities = 51/215 (23%), Positives = 92/215 (42%), Gaps = 31/215 (14%)
Query: 40 PRPDRVAIVTGGTDGIGYSTAKHLARLGMHVI--IAGNNDSKAKQVVSKIKEETLNDKVE 97
P + +VTGG G+G++ K+L LG V + N A+++ T + ++
Sbjct: 79 PVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEEL-----RRTCSPRLS 133
Query: 98 FLYCDLASMTSIRQFVQKF--KMKKIPLHVLINNAGVMMVP---QRKTRDGFEEHFGLNY 152
L D+ I+ K ++ L +INNAGV+ P + +++ +N+
Sbjct: 134 VLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNF 193
Query: 153 LGHFLLTNLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSK 212
G +T L L++S R+V VSS + A A+Y SK
Sbjct: 194 FGTVEVTKTFLPLLRKS-----KGRLVNVSS------------MGGGAPMERLASYGSSK 236
Query: 213 LALVLFTYHLQRLLAAEGSHVTANVVDPGVVNTDV 247
A+ +F+ ++ L+ G V + + PG T++
Sbjct: 237 AAVTMFSSVMRLELSKWGIKVAS--IQPGGFLTNI 269
>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 49.3 bits (116), Expect = 5e-06
Identities = 59/227 (25%), Positives = 103/227 (45%), Gaps = 33/227 (14%)
Query: 43 DRVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCD 102
D+ +TG G G A+ + G HVI A +S + + +K ET ++++ + D
Sbjct: 29 DKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGS----TALKAET-SERLRTVLLD 83
Query: 103 LASMTSIRQFVQ--KFKMKKIPLHVLINNAGV--MMVP-QRKTRDGFEEHFGLNYLGHFL 157
+ ++++ Q K ++ + L LINNAGV ++ P T + + E +N G
Sbjct: 84 VTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLIS 143
Query: 158 LTNLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVL 217
+T +L +K++ RV+ VSS +A + Y SK A+
Sbjct: 144 VTLNMLPLVKKA-----QGRVINVSSVGGRLAIVG-------------GGYTPSKYAVEG 185
Query: 218 FTYHLQRLLAAEGSHVTANVVDPGVVNTDVYKHVFWATRLAKKLLGW 264
F L+R + A G HV+ ++PG+ T++ V + KKL W
Sbjct: 186 FNDSLRRDMKAFGVHVSC--IEPGLFKTNLADPV---KVIEKKLAIW 227
>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 49.3 bits (116), Expect = 5e-06
Identities = 59/227 (25%), Positives = 103/227 (45%), Gaps = 33/227 (14%)
Query: 43 DRVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCD 102
D+ +TG G G A+ + G HVI A +S + + +K ET ++++ + D
Sbjct: 29 DKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGS----TALKAET-SERLRTVLLD 83
Query: 103 LASMTSIRQFVQ--KFKMKKIPLHVLINNAGV--MMVP-QRKTRDGFEEHFGLNYLGHFL 157
+ ++++ Q K ++ + L LINNAGV ++ P T + + E +N G
Sbjct: 84 VTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLIS 143
Query: 158 LTNLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVL 217
+T +L +K++ RV+ VSS +A + Y SK A+
Sbjct: 144 VTLNMLPLVKKA-----QGRVINVSSVGGRLAIVG-------------GGYTPSKYAVEG 185
Query: 218 FTYHLQRLLAAEGSHVTANVVDPGVVNTDVYKHVFWATRLAKKLLGW 264
F L+R + A G HV+ ++PG+ T++ V + KKL W
Sbjct: 186 FNDSLRRDMKAFGVHVSC--IEPGLFKTNLADPV---KVIEKKLAIW 227
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,954,951
Number of Sequences: 37866
Number of extensions: 491639
Number of successful extensions: 1093
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 1009
Number of HSP's gapped (non-prelim): 72
length of query: 330
length of database: 18,247,518
effective HSP length: 103
effective length of query: 227
effective length of database: 14,347,320
effective search space: 3256841640
effective search space used: 3256841640
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.