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Search of human proteins with 193788651
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
(347 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 700 0.0
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 119 5e-27
gi|45827729 scribble isoform b [Homo sapiens] 117 2e-26
gi|45827731 scribble isoform a [Homo sapiens] 117 2e-26
gi|238908508 leucine-rich repeat and death domain-containing pro... 112 6e-25
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 112 6e-25
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 111 1e-24
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 106 3e-23
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 100 3e-21
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 100 3e-21
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 99 6e-21
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 97 2e-20
gi|190014581 leucine rich repeat containing 2 [Homo sapiens] 97 3e-20
gi|27545328 leucine rich repeat containing 2 [Homo sapiens] 97 3e-20
gi|33859670 leucine-rich repeats and calponin homology (CH) doma... 94 2e-19
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 93 4e-19
gi|194394161 leucine rich repeat containing 57 [Homo sapiens] 92 7e-19
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 92 7e-19
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 91 1e-18
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 91 2e-18
gi|40217803 leucine rich repeat containing 8 family, member E [H... 90 3e-18
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 90 3e-18
gi|62241040 leucine rich repeat containing 8 family, member A [H... 90 3e-18
gi|187829877 leucine rich repeat containing 8 family, member A [... 90 3e-18
gi|187829871 leucine rich repeat containing 8 family, member A [... 90 3e-18
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 89 6e-18
gi|197333692 leucine rich repeat containing 8 family, member B [... 88 1e-17
gi|21245134 leucine rich repeat containing 8 family, member B [H... 88 1e-17
gi|63003903 leucine rich repeat containing 10 [Homo sapiens] 88 1e-17
gi|4503743 flightless I homolog [Homo sapiens] 86 4e-17
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 700 bits (1806), Expect = 0.0
Identities = 347/347 (100%), Positives = 347/347 (100%)
Query: 1 MTERLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLT 60
MTERLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLT
Sbjct: 1 MTERLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLT 60
Query: 61 QLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLT 120
QLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLT
Sbjct: 61 QLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLT 120
Query: 121 QLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQK 180
QLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQK
Sbjct: 121 QLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQK 180
Query: 181 LLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVI 240
LLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVI
Sbjct: 181 LLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVI 240
Query: 241 STQQENVWSLQEITSRFVMNQLAENNPFLMDDIERYPQVRSMISQGKTCAICGQYFITVW 300
STQQENVWSLQEITSRFVMNQLAENNPFLMDDIERYPQVRSMISQGKTCAICGQYFITVW
Sbjct: 241 STQQENVWSLQEITSRFVMNQLAENNPFLMDDIERYPQVRSMISQGKTCAICGQYFITVW 300
Query: 301 LECVRFVPPPKDWKISKNLKLVPLQVLICSYKCFTQRDPNLFGIAQV 347
LECVRFVPPPKDWKISKNLKLVPLQVLICSYKCFTQRDPNLFGIAQV
Sbjct: 301 LECVRFVPPPKDWKISKNLKLVPLQVLICSYKCFTQRDPNLFGIAQV 347
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 119 bits (297), Expect = 5e-27
Identities = 75/266 (28%), Positives = 136/266 (51%), Gaps = 4/266 (1%)
Query: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
+ L ++ +P ++G L LK L L N + ++ E+ NL L L++ N LE +PEE
Sbjct: 179 LDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEE 238
Query: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138
+ LTSL +L +S N + P L+ L +L ++ N LTQLP+ V +SLT + +
Sbjct: 239 ISGLTSLTDLVISQN-LLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLT 297
Query: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198
NQL ++P+ + L+ L L + N+L+ +P+EI L + N + +P E+
Sbjct: 298 ENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQA 357
Query: 199 KKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVISTQQENVWSLQEITSRFV 258
+L +LD+AGN + P LKL+ + N QP+++ Q + ++ E V
Sbjct: 358 TELHVLDVAGNRLLHLPLSLTALKLKALWLSDNQ---SQPLLTFQTDTDYTTGEKILTCV 414
Query: 259 MNQLAENNPFLMDDIERYPQVRSMIS 284
+ + P +++ R + ++++
Sbjct: 415 LLPQLPSEPTCQENLPRCGALENLVN 440
Score = 100 bits (250), Expect = 1e-21
Identities = 66/226 (29%), Positives = 111/226 (49%), Gaps = 22/226 (9%)
Query: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
+ L+ ++ ++P +L L+ L L +N I ++ PE+ N QL L++ N + E+PE
Sbjct: 41 LLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPES 100
Query: 79 MKYLTSLKNLHLSGNRICRFA----------------------PGACDGLQNLILLNLNN 116
+ + +L+ SGN + R P L NL L L
Sbjct: 101 ISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRE 160
Query: 117 NHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLK 176
N LT LP +++L+ L + + N++ ++P + L +L +L L+ NQL +P+EI LK
Sbjct: 161 NLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLK 220
Query: 177 KLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLK 222
L L ++ N + LPEE+ L L L I+ N+++ P G LK
Sbjct: 221 NLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLK 266
Score = 67.4 bits (163), Expect = 2e-11
Identities = 54/184 (29%), Positives = 83/184 (45%), Gaps = 26/184 (14%)
Query: 75 VPEEM-KYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133
VPEE+ +Y SL+ L L N++ R P L L L L++N + +LP E++ L
Sbjct: 27 VPEEIYRYARSLEELLLDANQL-RELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLV 85
Query: 134 YMSINYNQLASIPRELCF-----------------------LENLVELQLNYNQLICIPE 170
+ ++ N++ IP + F L+NL L +N L +PE
Sbjct: 86 ELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPE 145
Query: 171 EIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQD-LKLREFYCE 229
I L L L L N + LP+ L L++L LD+ N I P L L++ + +
Sbjct: 146 NIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLD 205
Query: 230 GNPL 233
GN L
Sbjct: 206 GNQL 209
Score = 56.2 bits (134), Expect = 4e-08
Identities = 43/159 (27%), Positives = 76/159 (47%), Gaps = 2/159 (1%)
Query: 6 LIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTL 65
L + +SG + + ++ + +P +GKL L L + N + ++ + LT L
Sbjct: 235 LPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTEL 294
Query: 66 NLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQE 125
L N L +P+ + L L NL+ N++ P G +L + + +N LT++P E
Sbjct: 295 VLTENQLLTLPKSIGKLKKLSNLNADRNKLVSL-PKEIGGCCSLTVFCVRDNRLTRIPAE 353
Query: 126 VSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQ 164
VS+ L + + N+L +P L L+ L L L+ NQ
Sbjct: 354 VSQATELHVLDVAGNRLLHLPLSLTALK-LKALWLSDNQ 391
Score = 51.6 bits (122), Expect = 1e-06
Identities = 36/129 (27%), Positives = 63/129 (48%), Gaps = 2/129 (1%)
Query: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
K I+ ++ ++T++P A+G+ L LVL N + + + L +L+ LN N L
Sbjct: 266 KKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLV 325
Query: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLK-SL 132
+P+E+ SL + NR+ R P L +L++ N L LP ++ LK
Sbjct: 326 SLPKEIGGCCSLTVFCVRDNRLTRI-PAEVSQATELHVLDVAGNRLLHLPLSLTALKLKA 384
Query: 133 TYMSINYNQ 141
++S N +Q
Sbjct: 385 LWLSDNQSQ 393
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 117 bits (292), Expect = 2e-26
Identities = 75/228 (32%), Positives = 116/228 (50%), Gaps = 4/228 (1%)
Query: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
+ L G + +P LG LP L+ L L N + + PEL NL +L L++ N LEE+P E
Sbjct: 179 LDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE 238
Query: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138
+ L L +L LS N + R P L+ L +L ++ N L ++ + + ++L+ + +
Sbjct: 239 LGGLVLLTDLLLSQNLLRRL-PDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILT 297
Query: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198
N L ++PR L L L L ++ N L +P EI L L L N + VLP EL
Sbjct: 298 ENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHT 357
Query: 199 KKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVISTQQEN 246
+L +LD+AGN +Q P L L+ + N QP++ Q E+
Sbjct: 358 TELHVLDVAGNRLQSLPFALTHLNLKALWLAENQ---AQPMLRFQTED 402
Score = 111 bits (278), Expect = 8e-25
Identities = 75/247 (30%), Positives = 128/247 (51%), Gaps = 8/247 (3%)
Query: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
+ L+ ++ ++P +L L+ L L +N I ++ PE+ N QL L++ N + E+PE
Sbjct: 41 LLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPES 100
Query: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138
+K+ +L+ SGN + R G L++L L LN+ L LP +V L +L + +
Sbjct: 101 IKFCKALEIADFSGNPLSRLPDGFTQ-LRSLAHLALNDVSLQALPGDVGNLANLVTLELR 159
Query: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198
N L S+P L FL L +L L N L +P+ + L L++L L RN + LP EL +L
Sbjct: 160 ENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNL 219
Query: 199 KKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVISTQQENVWSLQEITSRFV 258
++L LD++ N ++ P+ L L L L Q ++ + + L++++ V
Sbjct: 220 RRLVCLDVSENRLEELPAELGGLVLL------TDLLLSQNLLRRLPDGIGQLKQLSILKV 273
Query: 259 -MNQLAE 264
N+L E
Sbjct: 274 DQNRLCE 280
Score = 94.4 bits (233), Expect = 1e-19
Identities = 68/228 (29%), Positives = 110/228 (48%), Gaps = 2/228 (0%)
Query: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
K +I +G ++++P +L L L L + + + ++ NL L TL L NLL+
Sbjct: 105 KALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLK 164
Query: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133
+P + +L L+ L L GN + P L NL L L+ N L+ LP E+ L+ L
Sbjct: 165 SLPASLSFLVKLEQLDLGGNDL-EVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLV 223
Query: 134 YMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPE 193
+ ++ N+L +P EL L L +L L+ N L +P+ I LK+L L + +N + + E
Sbjct: 224 CLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTE 283
Query: 194 ELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPLFLQQPVI 240
+ D + L L + N++ P L KL + N L P I
Sbjct: 284 AIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
Score = 84.3 bits (207), Expect = 1e-16
Identities = 62/208 (29%), Positives = 99/208 (47%), Gaps = 1/208 (0%)
Query: 15 NTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEE 74
N + + L+ ++ ++P + L L + N IP++ + L + N L
Sbjct: 60 NLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSR 119
Query: 75 VPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTY 134
+P+ L SL +L L+ + + PG L NL+ L L N L LP +S L L
Sbjct: 120 LPDGFTQLRSLAHLALNDVSL-QALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQ 178
Query: 135 MSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEE 194
+ + N L +P L L NL EL L+ NQL +P E+ L++L L ++ N + LP E
Sbjct: 179 LDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE 238
Query: 195 LCDLKKLRILDIAGNIIQIFPSGFQDLK 222
L L L L ++ N+++ P G LK
Sbjct: 239 LGGLVLLTDLLLSQNLLRRLPDGIGQLK 266
Score = 59.3 bits (142), Expect = 5e-09
Identities = 35/105 (33%), Positives = 60/105 (57%), Gaps = 1/105 (0%)
Query: 119 LTQLPQEVSRL-KSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKK 177
L +P+E+ R +SL + ++ NQL +P+ L NL +L L+ N++ +P E+ +
Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
Query: 178 LQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLK 222
L +L ++RN+I +PE + K L I D +GN + P GF L+
Sbjct: 84 LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLR 128
Score = 55.5 bits (132), Expect = 7e-08
Identities = 44/151 (29%), Positives = 68/151 (45%), Gaps = 25/151 (16%)
Query: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
K I+ ++ ++ ++ A+G L L+L NL+ + L LT+LT LN+ N LE
Sbjct: 266 KQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLE 325
Query: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133
+P E+ G C L +L+L +N L LP E++ L
Sbjct: 326 ALPPEI---------------------GGCVALS---VLSLRDNRLAVLPPELAHTTELH 361
Query: 134 YMSINYNQLASIPRELCFLENLVELQLNYNQ 164
+ + N+L S+P L L NL L L NQ
Sbjct: 362 VLDVAGNRLQSLPFALTHL-NLKALWLAENQ 391
Score = 46.2 bits (108), Expect = 4e-05
Identities = 26/88 (29%), Positives = 46/88 (52%)
Query: 8 KALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNL 67
+A+ +N + L + +P +LGKL L L + N + + PE+ L+ L+L
Sbjct: 283 EAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSL 342
Query: 68 GNNLLEEVPEEMKYLTSLKNLHLSGNRI 95
+N L +P E+ + T L L ++GNR+
Sbjct: 343 RDNRLAVLPPELAHTTELHVLDVAGNRL 370
Score = 43.1 bits (100), Expect = 4e-04
Identities = 33/94 (35%), Positives = 49/94 (52%), Gaps = 2/94 (2%)
Query: 142 LASIPRELC-FLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKK 200
L ++P E+ + +L EL L+ NQL +P+ L L+KL L+ N I LP E+ + +
Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
Query: 201 LRILDIAGNIIQIFPSGFQDLKLREFY-CEGNPL 233
L LD++ N I P + K E GNPL
Sbjct: 84 LVELDVSRNDIPEIPESIKFCKALEIADFSGNPL 117
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 117 bits (292), Expect = 2e-26
Identities = 75/228 (32%), Positives = 116/228 (50%), Gaps = 4/228 (1%)
Query: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
+ L G + +P LG LP L+ L L N + + PEL NL +L L++ N LEE+P E
Sbjct: 179 LDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE 238
Query: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138
+ L L +L LS N + R P L+ L +L ++ N L ++ + + ++L+ + +
Sbjct: 239 LGGLVLLTDLLLSQNLLRRL-PDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILT 297
Query: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198
N L ++PR L L L L ++ N L +P EI L L L N + VLP EL
Sbjct: 298 ENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHT 357
Query: 199 KKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVISTQQEN 246
+L +LD+AGN +Q P L L+ + N QP++ Q E+
Sbjct: 358 TELHVLDVAGNRLQSLPFALTHLNLKALWLAENQ---AQPMLRFQTED 402
Score = 111 bits (278), Expect = 8e-25
Identities = 75/247 (30%), Positives = 128/247 (51%), Gaps = 8/247 (3%)
Query: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
+ L+ ++ ++P +L L+ L L +N I ++ PE+ N QL L++ N + E+PE
Sbjct: 41 LLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPES 100
Query: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138
+K+ +L+ SGN + R G L++L L LN+ L LP +V L +L + +
Sbjct: 101 IKFCKALEIADFSGNPLSRLPDGFTQ-LRSLAHLALNDVSLQALPGDVGNLANLVTLELR 159
Query: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198
N L S+P L FL L +L L N L +P+ + L L++L L RN + LP EL +L
Sbjct: 160 ENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNL 219
Query: 199 KKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVISTQQENVWSLQEITSRFV 258
++L LD++ N ++ P+ L L L L Q ++ + + L++++ V
Sbjct: 220 RRLVCLDVSENRLEELPAELGGLVLL------TDLLLSQNLLRRLPDGIGQLKQLSILKV 273
Query: 259 -MNQLAE 264
N+L E
Sbjct: 274 DQNRLCE 280
Score = 94.4 bits (233), Expect = 1e-19
Identities = 68/228 (29%), Positives = 110/228 (48%), Gaps = 2/228 (0%)
Query: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
K +I +G ++++P +L L L L + + + ++ NL L TL L NLL+
Sbjct: 105 KALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLK 164
Query: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133
+P + +L L+ L L GN + P L NL L L+ N L+ LP E+ L+ L
Sbjct: 165 SLPASLSFLVKLEQLDLGGNDL-EVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLV 223
Query: 134 YMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPE 193
+ ++ N+L +P EL L L +L L+ N L +P+ I LK+L L + +N + + E
Sbjct: 224 CLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTE 283
Query: 194 ELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPLFLQQPVI 240
+ D + L L + N++ P L KL + N L P I
Sbjct: 284 AIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
Score = 84.3 bits (207), Expect = 1e-16
Identities = 62/208 (29%), Positives = 99/208 (47%), Gaps = 1/208 (0%)
Query: 15 NTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEE 74
N + + L+ ++ ++P + L L + N IP++ + L + N L
Sbjct: 60 NLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSR 119
Query: 75 VPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTY 134
+P+ L SL +L L+ + + PG L NL+ L L N L LP +S L L
Sbjct: 120 LPDGFTQLRSLAHLALNDVSL-QALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQ 178
Query: 135 MSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEE 194
+ + N L +P L L NL EL L+ NQL +P E+ L++L L ++ N + LP E
Sbjct: 179 LDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE 238
Query: 195 LCDLKKLRILDIAGNIIQIFPSGFQDLK 222
L L L L ++ N+++ P G LK
Sbjct: 239 LGGLVLLTDLLLSQNLLRRLPDGIGQLK 266
Score = 59.3 bits (142), Expect = 5e-09
Identities = 35/105 (33%), Positives = 60/105 (57%), Gaps = 1/105 (0%)
Query: 119 LTQLPQEVSRL-KSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKK 177
L +P+E+ R +SL + ++ NQL +P+ L NL +L L+ N++ +P E+ +
Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
Query: 178 LQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLK 222
L +L ++RN+I +PE + K L I D +GN + P GF L+
Sbjct: 84 LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLR 128
Score = 55.5 bits (132), Expect = 7e-08
Identities = 44/151 (29%), Positives = 68/151 (45%), Gaps = 25/151 (16%)
Query: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
K I+ ++ ++ ++ A+G L L+L NL+ + L LT+LT LN+ N LE
Sbjct: 266 KQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLE 325
Query: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133
+P E+ G C L +L+L +N L LP E++ L
Sbjct: 326 ALPPEI---------------------GGCVALS---VLSLRDNRLAVLPPELAHTTELH 361
Query: 134 YMSINYNQLASIPRELCFLENLVELQLNYNQ 164
+ + N+L S+P L L NL L L NQ
Sbjct: 362 VLDVAGNRLQSLPFALTHL-NLKALWLAENQ 391
Score = 46.2 bits (108), Expect = 4e-05
Identities = 26/88 (29%), Positives = 46/88 (52%)
Query: 8 KALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNL 67
+A+ +N + L + +P +LGKL L L + N + + PE+ L+ L+L
Sbjct: 283 EAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSL 342
Query: 68 GNNLLEEVPEEMKYLTSLKNLHLSGNRI 95
+N L +P E+ + T L L ++GNR+
Sbjct: 343 RDNRLAVLPPELAHTTELHVLDVAGNRL 370
Score = 43.1 bits (100), Expect = 4e-04
Identities = 33/94 (35%), Positives = 49/94 (52%), Gaps = 2/94 (2%)
Query: 142 LASIPRELC-FLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKK 200
L ++P E+ + +L EL L+ NQL +P+ L L+KL L+ N I LP E+ + +
Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
Query: 201 LRILDIAGNIIQIFPSGFQDLKLREFY-CEGNPL 233
L LD++ N I P + K E GNPL
Sbjct: 84 LVELDVSRNDIPEIPESIKFCKALEIADFSGNPL 117
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 112 bits (279), Expect = 6e-25
Identities = 63/204 (30%), Positives = 110/204 (53%), Gaps = 1/204 (0%)
Query: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
++L+ K+T++P + KL L+ L + N + K+ + +L + +L N++ +VP E
Sbjct: 400 LSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIE 459
Query: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138
+K + + LS N+I F G C L +L L++N N+++++P ++S K L ++ ++
Sbjct: 460 IKNCQKIIKIELSYNKIMYFPLGLC-ALDSLYYLSVNGNYISEIPVDISFSKQLLHLELS 518
Query: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198
N+L C L NL L L NQ+ IP I + L L+L N P ELC L
Sbjct: 519 ENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTL 578
Query: 199 KKLRILDIAGNIIQIFPSGFQDLK 222
+ L++LD++ N +Q S +LK
Sbjct: 579 ENLQVLDLSENQLQKISSDICNLK 602
Score = 110 bits (274), Expect = 2e-24
Identities = 64/193 (33%), Positives = 107/193 (55%), Gaps = 4/193 (2%)
Query: 34 GKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGN 93
G L GL+ L LQ N + + E+ L L LN+ +N + +P+E+ L +++ L N
Sbjct: 185 GDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244
Query: 94 RICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLE 153
I F P + L NL +L+L N L +P + LK+L +++ YNQL + P+ LCFL
Sbjct: 245 YIENF-PSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLP 303
Query: 154 NLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQI 213
L+ L L N + +P+EI+ LK L+ LL+ N + L E+ L K++ L +A N +++
Sbjct: 304 KLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEV 363
Query: 214 FP---SGFQDLKL 223
F++L++
Sbjct: 364 ISHKIENFRELRI 376
Score = 99.0 bits (245), Expect = 6e-21
Identities = 70/255 (27%), Positives = 119/255 (46%), Gaps = 13/255 (5%)
Query: 15 NTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEE 74
N K + L ++ K+P+++ + L L+L N ELC L L L+L N L++
Sbjct: 534 NLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQK 593
Query: 75 VPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNN---NHLTQLPQEVSRLKS 131
+ ++ L ++ L+ S N+ F C LQ+L LN++ LT+LP E+S +
Sbjct: 594 ISSDICNLKGIQKLNFSSNQFIHFPIELCQ-LQSLEQLNISQIKGRKLTRLPGELSNMTQ 652
Query: 132 LTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVL 191
L + I+ N + IPR + L NLV L NQ+ +P + L LQ+L L+ NN+ L
Sbjct: 653 LKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTAL 712
Query: 192 PEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVISTQQENVWSLQ 251
P + ++ L+ ++ N + L+ C+G L+ + E +
Sbjct: 713 PSAIYNIFSLKEINFDDNPL---------LRPPVEICKGKQLYTIARYLQRADERDEKIL 763
Query: 252 EITSRFVMNQLAENN 266
E + V N + E N
Sbjct: 764 EKIFKIVANNITETN 778
Score = 95.9 bits (237), Expect = 5e-20
Identities = 59/199 (29%), Positives = 111/199 (55%), Gaps = 1/199 (0%)
Query: 17 KIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVP 76
+I++L ++ +PS + L L+ L + +N I + E+ L + L NN +E P
Sbjct: 191 EILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFP 250
Query: 77 EEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMS 136
+++ L +L+ L L N++ R P L+ L +LNL N LT P+ + L L +
Sbjct: 251 SDLECLGNLEILSLGKNKL-RHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLD 309
Query: 137 INYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELC 196
+ N ++S+P+E+ L+NL L +++N+L + EI L K+++L LA N + V+ ++
Sbjct: 310 LTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIE 369
Query: 197 DLKKLRILDIAGNIIQIFP 215
+ ++LRIL + N+++ P
Sbjct: 370 NFRELRILILDKNLLKNIP 388
Score = 94.4 bits (233), Expect = 1e-19
Identities = 67/238 (28%), Positives = 122/238 (51%), Gaps = 3/238 (1%)
Query: 15 NTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEE 74
N +I+ ++ ++ +P + +L ++ L NN I +L L L L+LG N L
Sbjct: 212 NLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRH 271
Query: 75 VPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTY 134
+P+ + L +L+ L+L N++ F C L LI L+L N ++ LP+E+ LK+L
Sbjct: 272 IPDTLPSLKTLRVLNLEYNQLTTFPKALCF-LPKLISLDLTGNLISSLPKEIRELKNLET 330
Query: 135 MSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEE 194
+ +++N+L + E+ L + ELQL N+L I +I+ ++L+ L+L +N + +PE+
Sbjct: 331 LLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEK 390
Query: 195 LCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPLFLQQPVISTQQENVWSLQ 251
+ L L ++ N + P L LR+ + N + IS N+ SL+
Sbjct: 391 ISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCIS-HLNNICSLE 447
Score = 94.4 bits (233), Expect = 1e-19
Identities = 62/189 (32%), Positives = 97/189 (51%), Gaps = 1/189 (0%)
Query: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
+ +G +T +P + + + L N I LC L L L++ N + E+P +
Sbjct: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505
Query: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138
+ + L +L LS N++ F+ C L NL L+L N + ++P +S + SL + +
Sbjct: 506 ISFSKQLLHLELSENKLLIFSEHFCS-LINLKYLDLGKNQIKKIPASISNMISLHVLILC 564
Query: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198
N+ + PRELC LENL L L+ NQL I +I LK +QKL + N P ELC L
Sbjct: 565 CNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQL 624
Query: 199 KKLRILDIA 207
+ L L+I+
Sbjct: 625 QSLEQLNIS 633
Score = 87.0 bits (214), Expect = 2e-17
Identities = 59/204 (28%), Positives = 106/204 (51%), Gaps = 1/204 (0%)
Query: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
K +++ L ++T P AL LP L +L L NLI + E+ L L TL + +N L
Sbjct: 280 KTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLT 339
Query: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133
+ E+ L +K L L+ N++ + + L +L L+ N L +P+++S L
Sbjct: 340 FLAVEIFQLLKIKELQLADNKL-EVISHKIENFRELRILILDKNLLKNIPEKISCCAMLE 398
Query: 134 YMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPE 193
+S++ N+L +P+ + L NL +L +N N ++ I + I L + L + N I +P
Sbjct: 399 CLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPI 458
Query: 194 ELCDLKKLRILDIAGNIIQIFPSG 217
E+ + +K+ ++++ N I FP G
Sbjct: 459 EIKNCQKIIKIELSYNKIMYFPLG 482
Score = 84.7 bits (208), Expect = 1e-16
Identities = 69/244 (28%), Positives = 114/244 (46%), Gaps = 34/244 (13%)
Query: 64 TLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123
T+NL L+E P+++ + +K L+L N+I F L L +L+L N L+ LP
Sbjct: 145 TVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLP 204
Query: 124 QEVSRLKSLTYMSINYNQLASIP---------RELCFLENLVE--------------LQL 160
E+ L +L +++++N ++ IP R+L F N +E L L
Sbjct: 205 SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSL 264
Query: 161 NYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQD 220
N+L IP+ + LK L+ L L N + P+ LC L KL LD+ GN+I P ++
Sbjct: 265 GKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRE 324
Query: 221 LKLREFYCEGNPLFLQQPVISTQQENVWSLQEITSRFVMNQLAENN-PFLMDDIERYPQV 279
LK E L + ++ ++ L +I QLA+N + IE + ++
Sbjct: 325 LKNLE------TLLMDHNKLTFLAVEIFQLLKIKEL----QLADNKLEVISHKIENFREL 374
Query: 280 RSMI 283
R +I
Sbjct: 375 RILI 378
Score = 71.2 bits (173), Expect = 1e-12
Identities = 47/162 (29%), Positives = 82/162 (50%), Gaps = 4/162 (2%)
Query: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLG---NN 70
+N +++ L+ ++ K+ S + L G++ L +N ELC L L LN+
Sbjct: 579 ENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGR 638
Query: 71 LLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLK 130
L +P E+ +T LK L +S N I R P L+NL+ L+ NN ++ LP + L
Sbjct: 639 KLTRLPGELSNMTQLKELDISNNAI-REIPRNIGELRNLVSLHAYNNQISYLPPSLLSLN 697
Query: 131 SLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEI 172
L ++++ N L ++P + + +L E+ + N L+ P EI
Sbjct: 698 DLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739
Score = 67.8 bits (164), Expect = 1e-11
Identities = 61/202 (30%), Positives = 94/202 (46%), Gaps = 1/202 (0%)
Query: 8 KALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNL 67
K +S N + + + PS L L L+ L L N + + L +L L LNL
Sbjct: 228 KEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNL 287
Query: 68 GNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVS 127
N L P+ + +L L +L L+GN I P L+NL L +++N LT L E+
Sbjct: 288 EYNQLTTFPKALCFLPKLISLDLTGNLISSL-PKEIRELKNLETLLMDHNKLTFLAVEIF 346
Query: 128 RLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNN 187
+L + + + N+L I ++ L L L+ N L IPE+I L+ L L+ N
Sbjct: 347 QLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNK 406
Query: 188 IGVLPEELCDLKKLRILDIAGN 209
+ LP+ + L LR L + N
Sbjct: 407 LTELPKYIHKLNNLRKLHVNRN 428
Score = 46.2 bits (108), Expect = 4e-05
Identities = 29/98 (29%), Positives = 46/98 (46%)
Query: 10 LSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGN 69
LS K + ++ + ++P +G+L L +L NN I + P L +L L LNL
Sbjct: 647 LSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSG 706
Query: 70 NLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQ 107
N L +P + + SLK ++ N + R C G Q
Sbjct: 707 NNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQ 744
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 112 bits (279), Expect = 6e-25
Identities = 78/254 (30%), Positives = 132/254 (51%), Gaps = 25/254 (9%)
Query: 18 IITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPE 77
++ ++ ++T +PSA+ +L L+ L + +N + + E+ NL L L L +N L + E
Sbjct: 109 VLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISE 168
Query: 78 EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSI 137
+ L++L++L LS N + P + L +L+ LNL++N L LP E++R+K L ++
Sbjct: 169 GFEQLSNLEDLDLSNNHLTT-VPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDC 227
Query: 138 NYNQLASIPRELCFLENLVELQLNYNQLICIPE--------------------EIKFLKK 177
N N L +IP EL +E+L L L N+L +PE E + LK
Sbjct: 228 NSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKH 287
Query: 178 LQKLL---LARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPL- 233
L +L L N + +P+E+ L+ L LD++ N I P +L L+ EGNPL
Sbjct: 288 LNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLR 347
Query: 234 FLQQPVISTQQENV 247
+++ +IS + V
Sbjct: 348 TIRREIISKGTQEV 361
Score = 92.4 bits (228), Expect = 5e-19
Identities = 59/217 (27%), Positives = 111/217 (51%), Gaps = 4/217 (1%)
Query: 10 LSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGN 69
L + + + L+G+ ++++P + ++ NL T LT L + N
Sbjct: 32 LKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISN 91
Query: 70 NLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRL 129
N L+ + ++++ L +L L + N++ P A L+NL LN+++N L LP+E++ L
Sbjct: 92 NKLQSLTDDLRLLPALTVLDIHDNQLTSL-PSAIRELENLQKLNVSHNKLKILPEEITNL 150
Query: 130 KSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIG 189
++L + + +N+L I L NL +L L+ N L +P L L +L L+ N +
Sbjct: 151 RNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELK 210
Query: 190 VLPEELCDLKKLRILDIAGNIIQIFP---SGFQDLKL 223
LP E+ +K+L+ LD N+++ P +G + L+L
Sbjct: 211 SLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLEL 247
Score = 89.4 bits (220), Expect = 4e-18
Identities = 55/195 (28%), Positives = 102/195 (52%), Gaps = 1/195 (0%)
Query: 39 LKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRF 98
L L++ NN + + +L L LT L++ +N L +P ++ L +L+ L++S N++ +
Sbjct: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKL-KI 142
Query: 99 APGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVEL 158
P L+NL L L +N LT + + +L +L + ++ N L ++P L +LV L
Sbjct: 143 LPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRL 202
Query: 159 QLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGF 218
L+ N+L +P EI +K+L+ L N + +P EL ++ L +L + N ++ P
Sbjct: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFP 262
Query: 219 QDLKLREFYCEGNPL 233
L+E + N +
Sbjct: 263 SCSLLKELHVGENQI 277
Score = 85.1 bits (209), Expect = 8e-17
Identities = 63/207 (30%), Positives = 107/207 (51%), Gaps = 4/207 (1%)
Query: 4 RLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLT 63
++L + ++ +N K + L ++T + +L L+ L L NN + V +L+ L
Sbjct: 141 KILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLV 200
Query: 64 TLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123
LNL +N L+ +P E+ + LK+L + N + P G+++L LL L N L LP
Sbjct: 201 RLNLSSNELKSLPAEINRMKRLKHLDCNSN-LLETIPPELAGMESLELLYLRRNKLRFLP 259
Query: 124 QEVSRLKSLTYMSINYNQLASIPRE-LCFLENLVELQLNYNQLICIPEEIKFLKKLQKLL 182
E L + + NQ+ + E L L +++ L L N+L +P+EI L+ L++L
Sbjct: 260 -EFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLD 318
Query: 183 LARNNIGVLPEELCDLKKLRILDIAGN 209
L+ N+I LP L +L L+ L + GN
Sbjct: 319 LSNNDISSLPYSLGNL-HLKFLALEGN 344
Score = 65.5 bits (158), Expect = 7e-11
Identities = 51/170 (30%), Positives = 84/170 (49%), Gaps = 26/170 (15%)
Query: 19 ITLNGKKMTKMPSALGKLPGLKTLV-LQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPE 77
I + ++ ++P + +L + + V L N + + ELC L +LT L+L NN L +PE
Sbjct: 430 INFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPE 489
Query: 78 EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSI 137
EM+ L L+ ++LS NR LP+ + R+ +L + I
Sbjct: 490 EMESLVRLQTINLSFNRF------------------------KMLPEVLYRIFTLETILI 525
Query: 138 NYNQLASI-PRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARN 186
+ NQ+ S+ P+++ +ENL L L N L+ IP E+ L+ LLL N
Sbjct: 526 SNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
Score = 63.5 bits (153), Expect = 3e-10
Identities = 59/229 (25%), Positives = 109/229 (47%), Gaps = 25/229 (10%)
Query: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNL-TQLTTLNLGNNLLEEVPE 77
+ L+ ++ +P +LG L LK L L+ N + + E+ + TQ L + + ++ P
Sbjct: 317 LDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPS 375
Query: 78 EMKYLT------------------SLKNLHLSGNRICRFAPGACDGLQNLIL--LNLNNN 117
+ + T +LK L S + D +++ I+ +N + N
Sbjct: 376 QSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKN 435
Query: 118 HLTQLPQEVSRLKSLTY-MSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLK 176
L ++P+ + LK + + +++N+L+ I ELC L+ L L L N L +PEE++ L
Sbjct: 436 QLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLV 495
Query: 177 KLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLRE 225
+LQ + L+ N +LPE L + L + I+ N Q+ Q +K+ E
Sbjct: 496 RLQTINLSFNRFKMLPEVLYRIFTLETILISNN--QVGSVDPQKMKMME 542
Score = 55.8 bits (133), Expect = 5e-08
Identities = 36/129 (27%), Positives = 68/129 (52%), Gaps = 1/129 (0%)
Query: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
+ L+ K++ + L L L L L+NN + + E+ +L +L T+NL N + +PE
Sbjct: 454 VDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEV 513
Query: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138
+ + +L+ + +S N++ P ++NL L+L NN L Q+P E+ +L + ++
Sbjct: 514 LYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLD 573
Query: 139 YNQLASIPR 147
N +PR
Sbjct: 574 GNPF-RVPR 581
Score = 31.2 bits (69), Expect = 1.4
Identities = 19/53 (35%), Positives = 27/53 (50%)
Query: 18 IITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNN 70
I+ N + + P + + L TL LQNN + ++ PEL N L TL L N
Sbjct: 523 ILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 111 bits (277), Expect = 1e-24
Identities = 69/217 (31%), Positives = 109/217 (50%), Gaps = 2/217 (0%)
Query: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNN-LLEEVPE 77
+ L ++ ++P + +L ++ L L N + +CP L L+ L +L+L N +
Sbjct: 53 VHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLV 112
Query: 78 EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSI 137
+ +L +L+ L L + L +L LL L NHL LP+E+ L + +
Sbjct: 113 VVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYL 172
Query: 138 NYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCD 197
NQ P+ELC L L + L+ N++ IPEEI L LQK +A NN+ VLP LC
Sbjct: 173 KRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQ 232
Query: 198 LKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPL 233
+L +LD++ N++ P F +L K+ E GN L
Sbjct: 233 CSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRL 269
Score = 103 bits (257), Expect = 2e-22
Identities = 67/224 (29%), Positives = 112/224 (50%), Gaps = 25/224 (11%)
Query: 17 KIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVP 76
+II L+ K+ +P +G L GL+ + +N +P + LC +QL+ L+L +NLL +P
Sbjct: 191 EIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIP 250
Query: 77 EEMKYLTSLKNLHLSGNR-------ICRFAP---------------GACDGLQNLILLNL 114
+ L + + LSGNR ICR+ G+ L NL L+L
Sbjct: 251 KSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDL 310
Query: 115 NNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKF 174
+ NHL P ++ LK+L + ++ N++ +P EL L L L L N+ + PEE+
Sbjct: 311 SQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLS 370
Query: 175 LKKLQKLLLARN---NIGVLPEELCDLKKLRILDIAGNIIQIFP 215
L L+KL + ++ + +PE + L+ L+ L I N ++ P
Sbjct: 371 LASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLP 414
Score = 94.0 bits (232), Expect = 2e-19
Identities = 75/275 (27%), Positives = 124/275 (45%), Gaps = 29/275 (10%)
Query: 17 KIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVP 76
+++ L G + +P + L+ + L+ N ELC L L ++L N + +P
Sbjct: 145 ELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIP 204
Query: 77 EEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMS 136
EE+ +LT L+ +++ N + C Q L +L+L++N L +P+ + L+ +T +
Sbjct: 205 EEIGHLTGLQKFYMASNNLPVLPASLCQCSQ-LSVLDLSHNLLHSIPKSFAELRKMTEIG 263
Query: 137 INYNQLASIPRELC-----------------------FLENLVELQLNYNQLICIPEEIK 173
++ N+L +PR +C L NL L L+ N L P +I
Sbjct: 264 LSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQIC 323
Query: 174 FLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNP 232
LK L+ L L N IG LP EL L KL+IL + GN FP L L + Y +
Sbjct: 324 ALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQ 383
Query: 233 LFLQQPVISTQQENVWSLQEITSRFVMNQLAENNP 267
F ++ E++ LQ + ++ N E P
Sbjct: 384 GF----KLTYVPEHIRKLQSLKELYIENNHLEYLP 414
Score = 80.5 bits (197), Expect = 2e-15
Identities = 55/184 (29%), Positives = 92/184 (50%), Gaps = 2/184 (1%)
Query: 15 NTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEE 74
N + + L+ + P + L L+ L L +N I ++ EL +L++L L L N
Sbjct: 304 NLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLS 363
Query: 75 VPEEMKYLTSLKNLHLSGNRICR--FAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSL 132
PEE+ L SL+ L++ ++ + + P LQ+L L + NNHL LP + + +L
Sbjct: 364 FPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNL 423
Query: 133 TYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLP 192
+ +N L +P +C + L EL+L N L +PE + L L+ L L N + P
Sbjct: 424 EVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPP 483
Query: 193 EELC 196
+E+C
Sbjct: 484 KEVC 487
Score = 73.9 bits (180), Expect = 2e-13
Identities = 64/238 (26%), Positives = 105/238 (44%), Gaps = 33/238 (13%)
Query: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKV----------------------CP-E 55
I L+G ++ K+P + + L L L N + ++ CP +
Sbjct: 262 IGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQ 321
Query: 56 LCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACD--GLQNLILLN 113
+C L L L L +N + ++P E+ L+ LK L L+GN F L+ L +
Sbjct: 322 ICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQ 381
Query: 114 LNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIK 173
LT +P+ + +L+SL + I N L +P L + NL L +N L +P+ I
Sbjct: 382 DQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAIC 441
Query: 174 FLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGN 231
+ L++L L N + LPE L L L++L + N ++ P +E EGN
Sbjct: 442 QAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPP--------KEVCAEGN 491
Score = 72.0 bits (175), Expect = 7e-13
Identities = 60/195 (30%), Positives = 88/195 (45%), Gaps = 27/195 (13%)
Query: 65 LNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQ 124
++ N L +P E+ T L+ +HL N+I P L+N+ +L L+ N+L L
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQI-EEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
Query: 125 EVSRLKSLTYMSINYNQLASIP----------RELCF---------------LENLVELQ 159
+ L SL + ++YN + S REL L +L L
Sbjct: 89 ALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLG 148
Query: 160 LNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQ 219
L N L C+P+EI KL+++ L RN V P+ELC L L I+D+ N I P
Sbjct: 149 LTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIG 208
Query: 220 DLK-LREFYCEGNPL 233
L L++FY N L
Sbjct: 209 HLTGLQKFYMASNNL 223
Score = 46.2 bits (108), Expect = 4e-05
Identities = 24/80 (30%), Positives = 43/80 (53%)
Query: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
++ K + + + +P +LG +P L+ L ++NL+ ++ +C L L L +NLL
Sbjct: 398 QSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLT 457
Query: 74 EVPEEMKYLTSLKNLHLSGN 93
+PE + L +LK L L N
Sbjct: 458 HLPENLDSLVNLKVLTLMDN 477
Score = 43.1 bits (100), Expect = 4e-04
Identities = 27/78 (34%), Positives = 42/78 (53%)
Query: 134 YMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPE 193
++ + L +IP E+ L E+ L NQ+ IP+EI+ LK ++ L L +NN+ L
Sbjct: 29 FIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
Query: 194 ELCDLKKLRILDIAGNII 211
L L L LD++ N I
Sbjct: 89 ALGLLSSLESLDLSYNPI 106
Score = 39.3 bits (90), Expect = 0.005
Identities = 25/96 (26%), Positives = 47/96 (48%), Gaps = 9/96 (9%)
Query: 9 ALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLG 68
+L N +++ + ++P A+ + LK L L++NL+ + L +L L L L
Sbjct: 416 SLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLM 475
Query: 69 NNLLEEVPEEM---------KYLTSLKNLHLSGNRI 95
+N +EE P+E+ KYL +N ++ +I
Sbjct: 476 DNPMEEPPKEVCAEGNEAIWKYLKENRNRNIMATKI 511
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 106 bits (265), Expect = 3e-23
Identities = 67/204 (32%), Positives = 107/204 (52%), Gaps = 2/204 (0%)
Query: 15 NTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEE 74
N + L+ +T +P +L L L+ L L++N + ++ + L LTTL L N +
Sbjct: 147 NLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITT 206
Query: 75 VPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTY 134
V +++K L+ L L + N+I + P L NLI L++ +N L LP+E+ +T
Sbjct: 207 VEKDIKNLSKLSMLSIRENKI-KQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITN 265
Query: 135 MSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEE 194
+ + +N+L +P + L +L L L YN+L IP + L++L L NNI LPE
Sbjct: 266 LDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPES 325
Query: 195 -LCDLKKLRILDIAGNIIQIFPSG 217
L L KL L +A N Q++P G
Sbjct: 326 LLSSLVKLNSLTLARNCFQLYPVG 349
Score = 92.8 bits (229), Expect = 4e-19
Identities = 71/256 (27%), Positives = 122/256 (47%), Gaps = 54/256 (21%)
Query: 18 IITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPE 77
++++ K+ ++P+ +G+L L TL + +N + + E+ N TQ+T L+L +N L ++P+
Sbjct: 219 MLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPD 278
Query: 78 EMKYLTSLKNLHLSGNRICRF--APGACDGLQNLILLNLNNNHLTQLPQEV--------- 126
+ L+SL L L NR+ + C L+ LNL NN+++ LP+ +
Sbjct: 279 TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEE---LNLENNNISTLPESLLSSLVKLNS 335
Query: 127 ----------------------------------------SRLKSLTYMSINYNQLASIP 146
SR K L+ +++ NQL S+P
Sbjct: 336 LTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLP 395
Query: 147 RELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDI 206
+ ++VEL L NQL IPE++ L L+ L+L+ N + LP L +L+KLR LD+
Sbjct: 396 LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDL 455
Query: 207 AGNIIQIFPSGFQDLK 222
N ++ P+ LK
Sbjct: 456 EENKLESLPNEIAYLK 471
Score = 89.4 bits (220), Expect = 4e-18
Identities = 78/293 (26%), Positives = 133/293 (45%), Gaps = 31/293 (10%)
Query: 21 LNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPE--LCNLTQLTTLNLGNNLLEEVPEE 78
L +++ +P +L K L+ L L+NN I + PE L +L +L +L L N + P
Sbjct: 291 LRYNRLSAIPRSLAKCSALEELNLENNNISTL-PESLLSSLVKLNSLTLARNCFQLYPVG 349
Query: 79 -MKYLTSLKNLHLSGNRICRFAPGACDGLQ-----------------------NLILLNL 114
+++ +L++ NRI + G + +++ LNL
Sbjct: 350 GPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNL 409
Query: 115 NNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKF 174
N LT++P++VS L SL + ++ N L +P L L L EL L N+L +P EI +
Sbjct: 410 ATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAY 469
Query: 175 LKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLK-LREFYCEGNPL 233
LK LQKL+L N + LP + L L L + N++ P L+ L E Y NP
Sbjct: 470 LKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPN 529
Query: 234 FLQQP--VISTQQENVWSLQEITSRFVMNQLAENNP-FLMDDIERYPQVRSMI 283
P + + ++ S++ + Q+ P F++ ++ R+M+
Sbjct: 530 LHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPSFIIQFLKMQGPYRAMV 582
Score = 87.0 bits (214), Expect = 2e-17
Identities = 52/159 (32%), Positives = 82/159 (51%), Gaps = 1/159 (0%)
Query: 57 CNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNN 116
C L+L + +P +K LT L L+L N++ + P L NL+ L L+
Sbjct: 97 CREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKL-QSLPAEVGCLVNLMTLALSE 155
Query: 117 NHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLK 176
N LT LP + LK L + + +N+L IP + L++L L L +N++ + ++IK L
Sbjct: 156 NSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLS 215
Query: 177 KLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFP 215
KL L + N I LP E+ +L L LD+A N ++ P
Sbjct: 216 KLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLP 254
Score = 85.1 bits (209), Expect = 8e-17
Identities = 61/189 (32%), Positives = 92/189 (48%), Gaps = 27/189 (14%)
Query: 10 LSGGKNTKIITLN--GKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNL 67
L G T ++ LN ++TK+P + L L+ L+L NNL+ K+ L NL +L L+L
Sbjct: 396 LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDL 455
Query: 68 GNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVS 127
N LE +P E+ YL L+ L L+ NN LT LP+ +
Sbjct: 456 EENKLESLPNEIAYLKDLQKLVLT------------------------NNQLTTLPRGIG 491
Query: 128 RLKSLTYMSINYNQLASIPRELCFLENLVELQLNYN-QLICIPEEIKFLKKLQKLLLARN 186
L +LT++ + N L +P E+ LENL EL LN N L +P E+ KL + +
Sbjct: 492 HLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENC 551
Query: 187 NIGVLPEEL 195
+ LP ++
Sbjct: 552 PLSHLPPQI 560
Score = 82.4 bits (202), Expect = 5e-16
Identities = 53/163 (32%), Positives = 90/163 (55%), Gaps = 1/163 (0%)
Query: 59 LTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNH 118
LTQLT L L +N L+ +P E+ L +L L LS N + P + D L+ L +L+L +N
Sbjct: 122 LTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSL-PDSLDNLKKLRMLDLRHNK 180
Query: 119 LTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKL 178
L ++P V RL SLT + + +N++ ++ +++ L L L + N++ +P EI L L
Sbjct: 181 LREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNL 240
Query: 179 QKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL 221
L +A N + LP+E+ + ++ LD+ N + P +L
Sbjct: 241 ITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNL 283
Score = 59.7 bits (143), Expect = 4e-09
Identities = 46/149 (30%), Positives = 71/149 (47%), Gaps = 1/149 (0%)
Query: 74 EVPEEMKYLTSLKNLHLS-GNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSL 132
EV +E+ ++ L R P + L L L L +N L LP EV L +L
Sbjct: 89 EVIKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNL 148
Query: 133 TYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLP 192
++++ N L S+P L L+ L L L +N+L IP + L L L L N I +
Sbjct: 149 MTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVE 208
Query: 193 EELCDLKKLRILDIAGNIIQIFPSGFQDL 221
+++ +L KL +L I N I+ P+ +L
Sbjct: 209 KDIKNLSKLSMLSIRENKIKQLPAEIGEL 237
Score = 58.5 bits (140), Expect = 8e-09
Identities = 38/125 (30%), Positives = 64/125 (51%), Gaps = 4/125 (3%)
Query: 6 LIKALSGG----KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQ 61
L+K L G + + + L K+ +P+ + L L+ LVL NN + + + +LT
Sbjct: 436 LLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTN 495
Query: 62 LTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQ 121
LT L LG NLL +PEE+ L +L+ L+L+ N P L ++++ N L+
Sbjct: 496 LTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSH 555
Query: 122 LPQEV 126
LP ++
Sbjct: 556 LPPQI 560
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 99.8 bits (247), Expect = 3e-21
Identities = 66/243 (27%), Positives = 125/243 (51%), Gaps = 5/243 (2%)
Query: 4 RLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLT 63
++L K ++ + + L + T++P L +L GLK + N + + + +L QLT
Sbjct: 174 KMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLT 233
Query: 64 TLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123
L++ N +E V E + +L++L LS N + + P L+N+ L ++ N L LP
Sbjct: 234 YLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQL-PETIGSLKNITTLKIDENQLMYLP 292
Query: 124 QEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLL 183
+ L S+ + ++N++ ++P + L NL ++N L +P EI K + L L
Sbjct: 293 DSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFL 352
Query: 184 ARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPLFLQQPVIST 242
N + LPEE+ D++KL++++++ N ++ P F L +L + N +P+I
Sbjct: 353 HSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ---SKPLIPL 409
Query: 243 QQE 245
Q+E
Sbjct: 410 QKE 412
Score = 82.8 bits (203), Expect = 4e-16
Identities = 59/217 (27%), Positives = 104/217 (47%), Gaps = 1/217 (0%)
Query: 6 LIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTL 65
L K L ++ ++L +T +P+++ L L+ L + N I + + N LT +
Sbjct: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
Query: 66 NLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQE 125
N + ++P+ L +L L+L+ + F P L L +L L N L LP+
Sbjct: 121 EASVNPISKLPDGFSQLLNLTQLYLN-DAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179
Query: 126 VSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLAR 185
++RL L + + N+ +P L L L E ++ N+L IP I LK+L L +++
Sbjct: 180 MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSK 239
Query: 186 NNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLK 222
NNI ++ E + + L+ L ++ N +Q P LK
Sbjct: 240 NNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLK 276
Score = 57.4 bits (137), Expect = 2e-08
Identities = 44/144 (30%), Positives = 75/144 (52%), Gaps = 6/144 (4%)
Query: 97 RFAPGACDGLQNLILLNLNNNH--LTQLPQEVSRL-KSLTYMSINYNQLASIPRELCFLE 153
R P C + + L+ +H L Q+P+E+ K+L + ++ NQ+ +P++L +
Sbjct: 10 RLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQ 69
Query: 154 NLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQI 213
+L +L L N L +P I L L++L +++N I PE + + K L I++ + N I
Sbjct: 70 SLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISK 129
Query: 214 FPSGF-QDLKLREFYCEGNPLFLQ 236
P GF Q L L + Y N FL+
Sbjct: 130 LPDGFSQLLNLTQLYL--NDAFLE 151
Score = 53.1 bits (126), Expect = 4e-07
Identities = 47/171 (27%), Positives = 79/171 (46%), Gaps = 31/171 (18%)
Query: 62 LTTLNLGNNLLEEVPEEM-KYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLT 120
+TTL+ + LE+VP+E+ + +L+ L+L N+I
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQI------------------------E 59
Query: 121 QLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQK 180
+LP+++ +SL +S+ N L ++P + L NL EL ++ N + PE IK K L
Sbjct: 60 ELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTI 119
Query: 181 LLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGF------QDLKLRE 225
+ + N I LP+ L L L + ++ P+ F Q L+LRE
Sbjct: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRE 170
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 99.8 bits (247), Expect = 3e-21
Identities = 66/243 (27%), Positives = 125/243 (51%), Gaps = 5/243 (2%)
Query: 4 RLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLT 63
++L K ++ + + L + T++P L +L GLK + N + + + +L QLT
Sbjct: 174 KMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLT 233
Query: 64 TLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123
L++ N +E V E + +L++L LS N + + P L+N+ L ++ N L LP
Sbjct: 234 YLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQL-PETIGSLKNITTLKIDENQLMYLP 292
Query: 124 QEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLL 183
+ L S+ + ++N++ ++P + L NL ++N L +P EI K + L L
Sbjct: 293 DSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFL 352
Query: 184 ARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPLFLQQPVIST 242
N + LPEE+ D++KL++++++ N ++ P F L +L + N +P+I
Sbjct: 353 HSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ---SKPLIPL 409
Query: 243 QQE 245
Q+E
Sbjct: 410 QKE 412
Score = 82.8 bits (203), Expect = 4e-16
Identities = 59/217 (27%), Positives = 104/217 (47%), Gaps = 1/217 (0%)
Query: 6 LIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTL 65
L K L ++ ++L +T +P+++ L L+ L + N I + + N LT +
Sbjct: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
Query: 66 NLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQE 125
N + ++P+ L +L L+L+ + F P L L +L L N L LP+
Sbjct: 121 EASVNPISKLPDGFSQLLNLTQLYLN-DAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179
Query: 126 VSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLAR 185
++RL L + + N+ +P L L L E ++ N+L IP I LK+L L +++
Sbjct: 180 MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSK 239
Query: 186 NNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLK 222
NNI ++ E + + L+ L ++ N +Q P LK
Sbjct: 240 NNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLK 276
Score = 57.4 bits (137), Expect = 2e-08
Identities = 44/144 (30%), Positives = 75/144 (52%), Gaps = 6/144 (4%)
Query: 97 RFAPGACDGLQNLILLNLNNNH--LTQLPQEVSRL-KSLTYMSINYNQLASIPRELCFLE 153
R P C + + L+ +H L Q+P+E+ K+L + ++ NQ+ +P++L +
Sbjct: 10 RLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQ 69
Query: 154 NLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQI 213
+L +L L N L +P I L L++L +++N I PE + + K L I++ + N I
Sbjct: 70 SLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISK 129
Query: 214 FPSGF-QDLKLREFYCEGNPLFLQ 236
P GF Q L L + Y N FL+
Sbjct: 130 LPDGFSQLLNLTQLYL--NDAFLE 151
Score = 53.1 bits (126), Expect = 4e-07
Identities = 47/171 (27%), Positives = 79/171 (46%), Gaps = 31/171 (18%)
Query: 62 LTTLNLGNNLLEEVPEEM-KYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLT 120
+TTL+ + LE+VP+E+ + +L+ L+L N+I
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQI------------------------E 59
Query: 121 QLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQK 180
+LP+++ +SL +S+ N L ++P + L NL EL ++ N + PE IK K L
Sbjct: 60 ELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTI 119
Query: 181 LLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGF------QDLKLRE 225
+ + N I LP+ L L L + ++ P+ F Q L+LRE
Sbjct: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRE 170
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 99.0 bits (245), Expect = 6e-21
Identities = 74/231 (32%), Positives = 119/231 (51%), Gaps = 25/231 (10%)
Query: 4 RLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLT 63
R L +AL T +++L+G+K+ + P +LT T
Sbjct: 47 RSLDRALEEAAVTGVLSLSGRKLREFPRGAANH---------------------DLTDTT 85
Query: 64 TLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123
+L N L E+P E + SL+NL+L N I R+ P A LQ L LN++ N L+ LP
Sbjct: 86 RADLSRNRLSEIPIEACHFVSLENLNLYQNCI-RYIPEAILNLQALTFLNISRNQLSTLP 144
Query: 124 QEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLL 183
+ L ++ N N+L S+P E+ L +L+EL ++ N++ IP +I L+ L+ L +
Sbjct: 145 VHLCNLPLKVLIASN-NKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNV 203
Query: 184 ARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLK-LREFYCEGNPL 233
RN++ LPEEL +L +R LD + N I P +++L+ L+ + NPL
Sbjct: 204 RRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPL 253
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 97.4 bits (241), Expect = 2e-20
Identities = 83/295 (28%), Positives = 141/295 (47%), Gaps = 18/295 (6%)
Query: 19 ITLNGKKMTKMPSALGKLPG-LKTLVLQNNLIPKVCPELCNLTQ-LTTLNLGNNLLEEVP 76
+ L + ++P LG G L+ LVL+ N ++ P + L LT L++ +N L +
Sbjct: 68 LNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALG 127
Query: 77 EEM-KYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYM 135
E+ L L+ L+LS N++ P L +L L+++ N L LP +S L L +
Sbjct: 128 AEVVSALRELRKLNLSHNQLPAL-PAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTL 186
Query: 136 SINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEEL 195
+++NQL + PR+L L L EL ++ N+L +PE+I L+ L+ L L+ +G LP
Sbjct: 187 DVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGF 246
Query: 196 CDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPV----ISTQQENVWSLQ 251
C+L L L + N +Q P+ F L+ + + LF + P ++ +E S
Sbjct: 247 CELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRN 306
Query: 252 EITS---------RFVMNQLAENN-PFLMDDIERYPQVRSMISQGKTCAICGQYF 296
++TS R + L N +L D I + ++ QG A+ +F
Sbjct: 307 QLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHF 361
Score = 97.4 bits (241), Expect = 2e-20
Identities = 71/215 (33%), Positives = 110/215 (51%), Gaps = 3/215 (1%)
Query: 25 KMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTS 84
++ +P +L L L+TL + +N + +L L L L++ +N L +PE++ L +
Sbjct: 169 RLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRA 228
Query: 85 LKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLAS 144
LK L LSG + G C+ L +L L L+NN L LP + S L+ L ++++ N
Sbjct: 229 LKILWLSGAELGTLPAGFCE-LASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEE 287
Query: 145 IPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRIL 204
P L L L EL L+ NQL +P I L +L L L N I LP+ + +L L L
Sbjct: 288 FPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEEL 347
Query: 205 DIAGNIIQIFPSGFQDL-KLREFYCEGNPLFLQQP 238
+ GN I + P F L ++ + + NPL +Q P
Sbjct: 348 VLQGNQIAVLPDHFGQLSRVGLWKIKDNPL-IQPP 381
Score = 96.3 bits (238), Expect = 4e-20
Identities = 70/217 (32%), Positives = 108/217 (49%), Gaps = 28/217 (12%)
Query: 31 SALGKLPGLKTLVLQNNLIPK-VCPELCNLTQLTTLNLGNNLLEEVPEEM-KYLTSLKNL 88
+A G PG L++ P+ V P NL + LNLGNN LEEVPE + L SL+ L
Sbjct: 35 TAAGACPGAGADALESPASPQLVLP--ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVL 92
Query: 89 HLSGNRICRFAPGACD------------------------GLQNLILLNLNNNHLTQLPQ 124
L NR R P + L+ L LNL++N L LP
Sbjct: 93 VLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPA 152
Query: 125 EVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLA 184
++ L L + +++N+LA +P L L L L +++NQL P ++ L L++L ++
Sbjct: 153 QLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVS 212
Query: 185 RNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL 221
N + LPE++ L+ L+IL ++G + P+GF +L
Sbjct: 213 SNRLRGLPEDISALRALKILWLSGAELGTLPAGFCEL 249
Score = 78.2 bits (191), Expect = 1e-14
Identities = 52/169 (30%), Positives = 87/169 (51%), Gaps = 1/169 (0%)
Query: 4 RLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLT 63
R L + +S + KI+ L+G ++ +P+ +L L++L+L NN + + + L +L
Sbjct: 217 RGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLK 276
Query: 64 TLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123
LNL +NL EE P + L L+ L+LS N++ P GL L+ L L+NN + LP
Sbjct: 277 MLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTS-VPSLISGLGRLLTLWLDNNRIRYLP 335
Query: 124 QEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEI 172
+ L L + + NQ+A +P L + ++ N LI P E+
Sbjct: 336 DSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEV 384
Score = 69.7 bits (169), Expect = 4e-12
Identities = 51/178 (28%), Positives = 83/178 (46%), Gaps = 1/178 (0%)
Query: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
+ ++ ++ +P + L LK L L + + C L L +L L NN L+ +P +
Sbjct: 209 LDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQ 268
Query: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138
L LK L+LS N F P A L L L L+ N LT +P +S L L + ++
Sbjct: 269 FSCLQRLKMLNLSSNLFEEF-PAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLD 327
Query: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELC 196
N++ +P + L L EL L NQ+ +P+ L ++ + N + P E+C
Sbjct: 328 NNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVC 385
>gi|190014581 leucine rich repeat containing 2 [Homo sapiens]
Length = 371
Score = 96.7 bits (239), Expect = 3e-20
Identities = 63/206 (30%), Positives = 113/206 (54%), Gaps = 6/206 (2%)
Query: 18 IITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQ-LTTLNLGNNLLEEVP 76
+ L+G+ T++P +L + L+ + N LI ++ P L Q + L+L N + +P
Sbjct: 102 VFELSGEHWTELPDSLKEQTHLREWYISNTLI-QIIPTYIQLFQAMRILDLPKNQISHLP 160
Query: 77 EEMKYLTSLKNLHLSGNRICRFAP--GACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTY 134
E+ L +LK L++ N + P G C+ L+ L N L +LP E+S LK +T+
Sbjct: 161 AEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSG--NLELMELPFELSNLKQVTF 218
Query: 135 MSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEE 194
+ I+ N+ +S+P + + NL L ++ N L +P++I L++LQ LL +N + LP
Sbjct: 219 VDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYS 278
Query: 195 LCDLKKLRILDIAGNIIQIFPSGFQD 220
+ +LKKL +L ++G+ + P+ D
Sbjct: 279 MLNLKKLTLLVVSGDHLVELPTALCD 304
Score = 38.5 bits (88), Expect = 0.009
Identities = 25/108 (23%), Positives = 49/108 (45%)
Query: 10 LSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGN 69
LS K + ++ K + +P + ++ L+ L + +N + + ++ L +L + L
Sbjct: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYK 269
Query: 70 NLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNN 117
N L +P M L L L +SG+ + CD L ++L +N
Sbjct: 270 NKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDN 317
>gi|27545328 leucine rich repeat containing 2 [Homo sapiens]
Length = 371
Score = 96.7 bits (239), Expect = 3e-20
Identities = 63/206 (30%), Positives = 113/206 (54%), Gaps = 6/206 (2%)
Query: 18 IITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQ-LTTLNLGNNLLEEVP 76
+ L+G+ T++P +L + L+ + N LI ++ P L Q + L+L N + +P
Sbjct: 102 VFELSGEHWTELPDSLKEQTHLREWYISNTLI-QIIPTYIQLFQAMRILDLPKNQISHLP 160
Query: 77 EEMKYLTSLKNLHLSGNRICRFAP--GACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTY 134
E+ L +LK L++ N + P G C+ L+ L N L +LP E+S LK +T+
Sbjct: 161 AEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSG--NLELMELPFELSNLKQVTF 218
Query: 135 MSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEE 194
+ I+ N+ +S+P + + NL L ++ N L +P++I L++LQ LL +N + LP
Sbjct: 219 VDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYS 278
Query: 195 LCDLKKLRILDIAGNIIQIFPSGFQD 220
+ +LKKL +L ++G+ + P+ D
Sbjct: 279 MLNLKKLTLLVVSGDHLVELPTALCD 304
Score = 38.5 bits (88), Expect = 0.009
Identities = 25/108 (23%), Positives = 49/108 (45%)
Query: 10 LSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGN 69
LS K + ++ K + +P + ++ L+ L + +N + + ++ L +L + L
Sbjct: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYK 269
Query: 70 NLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNN 117
N L +P M L L L +SG+ + CD L ++L +N
Sbjct: 270 NKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDN 317
>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
containing 1 [Homo sapiens]
Length = 728
Score = 93.6 bits (231), Expect = 2e-19
Identities = 64/177 (36%), Positives = 102/177 (57%), Gaps = 4/177 (2%)
Query: 58 NLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNN 117
+L+ +L N L EVP E+ + SL+ L+L N I R P A LQ L LNL+ N
Sbjct: 95 DLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCI-RVIPEAIVNLQMLTYLNLSRN 153
Query: 118 HLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKK 177
L+ LP + L ++ N N+L S+P E+ L+ L+EL ++ N++ +P++I LK
Sbjct: 154 QLSALPACLCGLPLKVLIASN-NKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKS 212
Query: 178 LQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLK-LREFYCEGNPL 233
L++L + RN + VLP+EL DL ++ D + N + + P F+++K L+ E NPL
Sbjct: 213 LRELNVRRNYLKVLPQELVDLPLVK-FDFSCNKVLVIPICFREMKQLQVLLLENNPL 268
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 92.8 bits (229), Expect = 4e-19
Identities = 57/204 (27%), Positives = 105/204 (51%), Gaps = 1/204 (0%)
Query: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
+ L + ++P L ++ L+ L + NN + + + L L L++ N +E V +
Sbjct: 189 LDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMD 248
Query: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138
+ +L++L LS N + + P + L+ L L +++N LT LP + L L +
Sbjct: 249 ISGCEALEDLLLSSNMLQQL-PDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCS 307
Query: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198
N+L S+P + +L +L L ++ N L +P EI K + + L N + LPEE+ +
Sbjct: 308 CNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQM 367
Query: 199 KKLRILDIAGNIIQIFPSGFQDLK 222
+KLR+L+++ N ++ P F LK
Sbjct: 368 QKLRVLNLSDNRLKNLPFSFTKLK 391
Score = 85.1 bits (209), Expect = 8e-17
Identities = 63/229 (27%), Positives = 111/229 (48%), Gaps = 8/229 (3%)
Query: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
+N + + ++ + +P ++GKL L L + N I V ++ L L L +N+L+
Sbjct: 207 QNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQ 266
Query: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133
++P+ + L L L + N++ P L L + + N L LP + L SL
Sbjct: 267 QLPDSIGLLKKLTTLKVDDNQLTML-PNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLR 325
Query: 134 YMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPE 193
++++ N L +PRE+ +N+ + L N+L +PEEI ++KL+ L L+ N + LP
Sbjct: 326 TLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPF 385
Query: 194 ELCDLKKLRILDIAGN----IIQIFPSGFQDLKLREFYCEGNPLFLQQP 238
LK+L L ++ N +I + + K R N +F QQP
Sbjct: 386 SFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVL---TNYMFPQQP 431
Score = 77.8 bits (190), Expect = 1e-14
Identities = 64/252 (25%), Positives = 110/252 (43%), Gaps = 25/252 (9%)
Query: 6 LIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTL 65
L K L + + +++ ++ +P+ + L LK L + N + + + LT +
Sbjct: 61 LPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTII 120
Query: 66 NLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQE 125
N + ++P+ L +L L+L+ + F P L L +L L NHL LP+
Sbjct: 121 EASVNPISKLPDGFTQLLNLTQLYLN-DAFLEFLPANFGRLVKLRILELRENHLKTLPKS 179
Query: 126 VSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLK--------- 176
+ +L L + + N+ +P L ++NL EL ++ N L +P I LK
Sbjct: 180 MHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSK 239
Query: 177 --------------KLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLK 222
L+ LLL+ N + LP+ + LKKL L + N + + P+ +L
Sbjct: 240 NRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLS 299
Query: 223 -LREFYCEGNPL 233
L EF C N L
Sbjct: 300 LLEEFDCSCNEL 311
Score = 60.5 bits (145), Expect = 2e-09
Identities = 49/190 (25%), Positives = 90/190 (47%), Gaps = 2/190 (1%)
Query: 62 LTTLNLGNNLLEEVPEEM-KYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLT 120
++ L+ + L++VP+E+ + +L+ L+L N+I P Q L L++ +N L+
Sbjct: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEEL-PKQLFNCQALRKLSIPDNDLS 82
Query: 121 QLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQK 180
LP ++ L +L + I+ N + P + + L ++ + N + +P+ L L +
Sbjct: 83 NLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQ 142
Query: 181 LLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVI 240
L L + LP L KLRIL++ N ++ P L E GN F + P +
Sbjct: 143 LYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEV 202
Query: 241 STQQENVWSL 250
Q +N+ L
Sbjct: 203 LDQIQNLREL 212
>gi|194394161 leucine rich repeat containing 57 [Homo sapiens]
Length = 239
Score = 92.0 bits (227), Expect = 7e-19
Identities = 62/202 (30%), Positives = 102/202 (50%), Gaps = 28/202 (13%)
Query: 15 NTKIITLNGKKMTKMPSAL-GKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
N + I L+ K+ +P L GK LK+L L NN + + E+CNL +L TL+L NN L
Sbjct: 39 NLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLR 98
Query: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133
E+P L++LK L LSGN++ P C L++L +++L+ N + +P V L+
Sbjct: 99 ELPSTFGQLSALKTLSLSGNQLGALPPQLC-SLRHLDVMDLSKNQIRSIPDSVGELQ--- 154
Query: 134 YMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARN--NIGVL 191
++EL LN NQ+ I +I +L+ L L N + +L
Sbjct: 155 ---------------------VIELNLNQNQISQISVKISCCPRLKILRLEENCLELSML 193
Query: 192 PEELCDLKKLRILDIAGNIIQI 213
P+ + ++ +L + GN+ +I
Sbjct: 194 PQSILSDSQICLLAVEGNLFEI 215
Score = 74.3 bits (181), Expect = 1e-13
Identities = 42/127 (33%), Positives = 69/127 (54%), Gaps = 1/127 (0%)
Query: 108 NLILLNLNNNHLTQLPQE-VSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLI 166
NL ++L+NN + LP + + L +S+N N+L +P E+C L+ L L LN N L
Sbjct: 39 NLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLR 98
Query: 167 CIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREF 226
+P L L+ L L+ N +G LP +LC L+ L ++D++ N I+ P +L++ E
Sbjct: 99 ELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIEL 158
Query: 227 YCEGNPL 233
N +
Sbjct: 159 NLNQNQI 165
Score = 72.8 bits (177), Expect = 4e-13
Identities = 46/133 (34%), Positives = 72/133 (54%), Gaps = 1/133 (0%)
Query: 72 LEEVPEEMKYLTS-LKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLK 130
L E P +++ LTS L+ + LS N+I P L L+LNNN LT LP E+ LK
Sbjct: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
Query: 131 SLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGV 190
L +S+N N L +P L L L L+ NQL +P ++ L+ L + L++N I
Sbjct: 86 KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRS 145
Query: 191 LPEELCDLKKLRI 203
+P+ + +L+ + +
Sbjct: 146 IPDSVGELQVIEL 158
Score = 58.2 bits (139), Expect = 1e-08
Identities = 34/128 (26%), Positives = 67/128 (52%), Gaps = 2/128 (1%)
Query: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
K + ++LN + ++PS G+L LKTL L N + + P+LC+L L ++L N +
Sbjct: 85 KKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIR 144
Query: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPG-ACDGLQNLILLNLNNNHLTQLPQEVSRLKSL 132
+P+ + L ++ L+L+ N+I + + +C ++ L N L+ LPQ + +
Sbjct: 145 SIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQI 203
Query: 133 TYMSINYN 140
+++ N
Sbjct: 204 CLLAVEGN 211
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 92.0 bits (227), Expect = 7e-19
Identities = 66/207 (31%), Positives = 106/207 (51%), Gaps = 1/207 (0%)
Query: 10 LSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGN 69
L G + +L + MT +P L L ++ L L +N + + PE+ LT++ LNL
Sbjct: 44 LKRGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCG 103
Query: 70 NLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRL 129
N L+ +P E+ L LK L ++ N + P + L +L+L++N L+QLP + L
Sbjct: 104 NRLKSLPREVSLLQCLKVLFVNMNCLTE-VPAELSLCRKLEVLSLSHNCLSQLPACFADL 162
Query: 130 KSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIG 189
L ++++ N A IP + L+ L+ L + N+L I E I+ L LQ + NNI
Sbjct: 163 SRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIH 222
Query: 190 VLPEELCDLKKLRILDIAGNIIQIFPS 216
P LC + L +L++ N IQ PS
Sbjct: 223 SFPRSLCLVTSLELLNLNNNDIQTLPS 249
Score = 84.0 bits (206), Expect = 2e-16
Identities = 53/171 (30%), Positives = 86/171 (50%), Gaps = 3/171 (1%)
Query: 13 GKNTKIITLN--GKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNN 70
GK T+I+ LN G ++ +P + L LK L + N + +V EL +L L+L +N
Sbjct: 91 GKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHN 150
Query: 71 LLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLK 130
L ++P L+ L+ L+LS N P L+ LI L++ +N L + + + L
Sbjct: 151 CLSQLPACFADLSRLRKLNLSNNFFAHI-PMCVFSLKELIFLHVGSNRLENIAESIQHLA 209
Query: 131 SLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKL 181
SL N + S PR LC + +L L LN N + +P E+ L +L ++
Sbjct: 210 SLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRI 260
Score = 78.6 bits (192), Expect = 8e-15
Identities = 52/161 (32%), Positives = 84/161 (52%), Gaps = 2/161 (1%)
Query: 72 LEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKS 131
+ ++P+ + L+ ++ L+LS N++ R P L +++LNL N L LP+EVS L+
Sbjct: 60 MTDIPDFLWGLSEVQKLNLSHNQL-RVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQC 118
Query: 132 LTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVL 191
L + +N N L +P EL L L L++N L +P L +L+KL L+ N +
Sbjct: 119 LKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHI 178
Query: 192 PEELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGN 231
P + LK+L L + N ++ Q L L+ F EGN
Sbjct: 179 PMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGN 219
Score = 61.2 bits (147), Expect = 1e-09
Identities = 47/178 (26%), Positives = 89/178 (50%), Gaps = 11/178 (6%)
Query: 110 ILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIP 169
+ +L +T +P + L + +++++NQL +P E+ L +V L L N+L +P
Sbjct: 51 VSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLP 110
Query: 170 EEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYC 228
E+ L+ L+ L + N + +P EL +KL +L ++ N + P+ F DL +LR+
Sbjct: 111 REVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNL 170
Query: 229 EGNPLFLQQPVISTQQENVWSLQEITSRFVMNQLAENNPFLMDDIERYPQVRSMISQG 286
N F P+ V+SL+E+ V + EN + + I+ ++ I++G
Sbjct: 171 SNN-FFAHIPMC------VFSLKELIFLHVGSNRLEN---IAESIQHLASLQIFIAEG 218
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 91.3 bits (225), Expect = 1e-18
Identities = 67/211 (31%), Positives = 108/211 (51%), Gaps = 11/211 (5%)
Query: 11 SGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLI--PKVCPE------LCNLTQL 62
SG + +++ ++G +T + L L GL+TL+ +NN + P P+ LC L
Sbjct: 65 SGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCR--SL 122
Query: 63 TTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQL 122
LNL N +EVP + L +L+ L L GN++ + P + LQ+L L L N + ++
Sbjct: 123 QVLNLSGNCFQEVPASLLELRALQTLSLGGNQL-QSIPAEIENLQSLECLYLGGNFIKEI 181
Query: 123 PQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLL 182
P E+ L SL Y+ + N++ SIP +L L +L L L+ N L +P EI L L++L
Sbjct: 182 PPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELS 241
Query: 183 LARNNIGVLPEELCDLKKLRILDIAGNIIQI 213
L N + V +L++A I+I
Sbjct: 242 LRGNPLVVRFVRDLTYDPPTLLELAARTIKI 272
Score = 82.4 bits (202), Expect = 5e-16
Identities = 86/318 (27%), Positives = 139/318 (43%), Gaps = 34/318 (10%)
Query: 19 ITLNGKKMTKMPSALGK-LPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPE 77
+ L ++ +P ALG P L+ L + N + + PEL L L TL NN L
Sbjct: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSA 108
Query: 78 EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSI 137
K L + +CR +L +LNL+ N ++P + L++L +S+
Sbjct: 109 LPKGLAQ--------SPLCR----------SLQVLNLSGNCFQEVPASLLELRALQTLSL 150
Query: 138 NYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCD 197
NQL SIP E+ L++L L L N + IP E+ L L L+L N I +P +L
Sbjct: 151 GGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQ 210
Query: 198 LKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPLFLQQPVISTQQENVWSLQEITSR 256
L LR L + N++ P +L L E GNPL ++ + + +L E+ +R
Sbjct: 211 LHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVR--FVRDLTYDPPTLLELAAR 268
Query: 257 FVMNQLAENNPF-LMDDIERYPQVRSMISQGKTCAICGQYFITVWLECVRFVPPPKDWKI 315
+ + P+ L ++ RY S K CG + + ++FV +++
Sbjct: 269 TIKIRNISYTPYDLPGNLLRYLGSASNCPNPK----CGGVYFDCCVRQIKFVDFCGKYRL 324
Query: 316 SKNLKLVPLQVLICSYKC 333
PL +CS +C
Sbjct: 325 -------PLMHYLCSPEC 335
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 90.5 bits (223), Expect = 2e-18
Identities = 54/188 (28%), Positives = 98/188 (52%)
Query: 26 MTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSL 85
+ K+P +G+ L L L N I ++ P + LT+L L L N ++ VP+E+ SL
Sbjct: 95 LLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASL 154
Query: 86 KNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASI 145
+ L L+ NR P L L L+L+ N T +P V + +L ++ + N+L +
Sbjct: 155 EKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQL 214
Query: 146 PRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILD 205
P + ++NL L L N++ C+P+ I +K L L+L+ N + +P + ++ LR ++
Sbjct: 215 PDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVN 274
Query: 206 IAGNIIQI 213
N +++
Sbjct: 275 FRDNPLKL 282
Score = 87.4 bits (215), Expect = 2e-17
Identities = 65/221 (29%), Positives = 110/221 (49%), Gaps = 3/221 (1%)
Query: 18 IITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPE 77
I+ + ++ +PS+L KL L+ L + K+ + L L+L N + E+P
Sbjct: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123
Query: 78 EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLN-NNHLTQLPQEVSRLKSLTYMS 136
+ LT L+ L LS N+I + P +L L L N + LPQE+S L LT++
Sbjct: 124 GIGLLTRLQELILSYNKI-KTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLD 182
Query: 137 INYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELC 196
++ N +IP + + L L + N+L +P+ I+ ++ L L L RN I LP+ +
Sbjct: 183 LSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTIS 242
Query: 197 DLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPLFLQ 236
++K L L ++ N +Q P +++ LR NPL L+
Sbjct: 243 NMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLK 283
Score = 63.5 bits (153), Expect = 3e-10
Identities = 44/152 (28%), Positives = 78/152 (51%), Gaps = 1/152 (0%)
Query: 100 PGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQ 159
P + L L L+ L ++P+ + R ++L + ++ N ++ IP + L L EL
Sbjct: 76 PSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELI 135
Query: 160 LNYNQLICIPEEIKFLKKLQKLLLARN-NIGVLPEELCDLKKLRILDIAGNIIQIFPSGF 218
L+YN++ +P+E+ L+KL LA N +I LP+EL +L KL LD++ N P
Sbjct: 136 LSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAV 195
Query: 219 QDLKLREFYCEGNPLFLQQPVISTQQENVWSL 250
++ E+ G+ Q P + +N+ +L
Sbjct: 196 LNMPALEWLDMGSNKLEQLPDTIERMQNLHTL 227
Score = 52.4 bits (124), Expect = 6e-07
Identities = 30/100 (30%), Positives = 51/100 (51%)
Query: 110 ILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIP 169
++L + LP + +L L ++ L IP + +NL+ L L+ N + IP
Sbjct: 63 VILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIP 122
Query: 170 EEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGN 209
I L +LQ+L+L+ N I +P+EL + L L++A N
Sbjct: 123 PGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVN 162
Score = 43.1 bits (100), Expect = 4e-04
Identities = 31/97 (31%), Positives = 50/97 (51%)
Query: 119 LTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKL 178
LT+L ++V+R + I + ++P L L L E QL+ L+ IPE I + L
Sbjct: 49 LTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNL 108
Query: 179 QKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFP 215
L L+RN I +P + L +L+ L ++ N I+ P
Sbjct: 109 IVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVP 145
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 90.1 bits (222), Expect = 3e-18
Identities = 67/202 (33%), Positives = 111/202 (54%), Gaps = 11/202 (5%)
Query: 26 MTKMPSALGKLPGLKTLVLQNNLIPKVCPELC--NLTQLTTLNLGNNLLEEVPEEMKYLT 83
+ ++P A+ L L+ L L++N + + L + +L TL L +N + VPE ++ L
Sbjct: 594 LERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLR 653
Query: 84 SLKNLHLSGNRICRFAP--GACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQ 141
SL+ L+LS N++ G C GL+ LL++++N L LP EV L++L +++++YN
Sbjct: 654 SLEQLYLSYNKLETLPSQLGLCSGLR---LLDVSHNGLHSLPPEVGLLQNLQHLALSYNA 710
Query: 142 LASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCD---L 198
L ++P EL F L L L NQL + + L+ L +L L N + LPEEL + L
Sbjct: 711 LEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGL 770
Query: 199 KKLRILDIAGNIIQIFPSGFQD 220
KK +L + + Q P+ +D
Sbjct: 771 KKAGLL-VEDTLYQGLPAEVRD 791
Score = 82.4 bits (202), Expect = 5e-16
Identities = 58/187 (31%), Positives = 97/187 (51%), Gaps = 3/187 (1%)
Query: 31 SALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPE--EMKYLTSLKNL 88
++L KL L+ L L + ++ + +L L L+L +N L + E ++ L L
Sbjct: 576 NSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTL 635
Query: 89 HLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRE 148
L N+I + P L++L L L+ N L LP ++ L + +++N L S+P E
Sbjct: 636 RLWHNQIA-YVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPE 694
Query: 149 LCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAG 208
+ L+NL L L+YN L +PEE+ F +KL+ LLL N + L + L+ L L++ G
Sbjct: 695 VGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKG 754
Query: 209 NIIQIFP 215
N ++ P
Sbjct: 755 NRLEALP 761
Score = 57.0 bits (136), Expect = 2e-08
Identities = 37/112 (33%), Positives = 57/112 (50%), Gaps = 1/112 (0%)
Query: 21 LNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMK 80
L+ K+ +PS LG GL+ L + +N + + PE+ L L L L N LE +PEE+
Sbjct: 660 LSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELF 719
Query: 81 YLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSL 132
+ L+ L L N++ + +P L+ L L L N L LP+E+ L
Sbjct: 720 FCRKLRTLLLGDNQLSQLSPHV-GALRALSRLELKGNRLEALPEELGNCGGL 770
Score = 43.5 bits (101), Expect = 3e-04
Identities = 33/112 (29%), Positives = 54/112 (48%), Gaps = 3/112 (2%)
Query: 17 KIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVP 76
+++ ++ + +P +G L L+ L L N + + EL +L TL LG+N L ++
Sbjct: 679 RLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLS 738
Query: 77 EEMKYLTSLKNLHLSGNRICRFAP--GACDGLQNLILLNLNNNHLTQLPQEV 126
+ L +L L L GNR+ G C GL+ LL + + LP EV
Sbjct: 739 PHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLL-VEDTLYQGLPAEV 789
Score = 36.6 bits (83), Expect = 0.034
Identities = 23/77 (29%), Positives = 39/77 (50%)
Query: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
+N + + L+ + +P L L+TL+L +N + ++ P + L L+ L L N LE
Sbjct: 699 QNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLE 758
Query: 74 EVPEEMKYLTSLKNLHL 90
+PEE+ LK L
Sbjct: 759 ALPEELGNCGGLKKAGL 775
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 90.1 bits (222), Expect = 3e-18
Identities = 63/212 (29%), Positives = 106/212 (50%), Gaps = 6/212 (2%)
Query: 8 KALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLV---LQNNLIPKVCPELCNLTQLTT 64
+AL T + L+ +++ P + L + L N P+V C L L
Sbjct: 36 RALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEG 95
Query: 65 LNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQ 124
L+L +N L + + LT+L L+LS N++ P C L +L ++NN L LP
Sbjct: 96 LSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQ--LPLRVLIVSNNKLGALPP 153
Query: 125 EVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLA 184
++ L SL + ++ N+L S+P ELC L +L +L + NQL +PEE+ L L +L +
Sbjct: 154 DIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFS 212
Query: 185 RNNIGVLPEELCDLKKLRILDIAGNIIQIFPS 216
N + +P C L+ L+++ + N +Q P+
Sbjct: 213 CNRVSRIPVSFCRLRHLQVILLDSNPLQSPPA 244
Score = 72.8 bits (177), Expect = 4e-13
Identities = 55/163 (33%), Positives = 82/163 (50%), Gaps = 5/163 (3%)
Query: 64 TLNLGNNLLEEVPEEMKY---LTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLT 120
TLNL N L+ P L+ + LS NR AC L +L L+L +N L
Sbjct: 46 TLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQ-LVSLEGLSLYHNCLR 104
Query: 121 QLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQK 180
L + L +LTY++++ NQL+ +P +C L V + N N+L +P +I L L++
Sbjct: 105 CLNPALGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVSN-NKLGALPPDIGTLGSLRQ 163
Query: 181 LLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKL 223
L ++ N + LP ELC L LR L++ N + P DL L
Sbjct: 164 LDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPL 206
Score = 58.5 bits (140), Expect = 8e-09
Identities = 38/147 (25%), Positives = 79/147 (53%), Gaps = 3/147 (2%)
Query: 4 RLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLT 63
R L AL + L+ +++ +P + +LP L+ L++ NN + + P++ L L
Sbjct: 104 RCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLR 162
Query: 64 TLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123
L++ +N L+ +P E+ L+SL++L++ N++ D L+ L+ + N ++++P
Sbjct: 163 QLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGD--LPLVRLDFSCNRVSRIP 220
Query: 124 QEVSRLKSLTYMSINYNQLASIPRELC 150
RL+ L + ++ N L S P ++C
Sbjct: 221 VSFCRLRHLQVILLDSNPLQSPPAQVC 247
Score = 55.8 bits (133), Expect = 5e-08
Identities = 39/126 (30%), Positives = 60/126 (47%), Gaps = 5/126 (3%)
Query: 112 LNLNNNHLTQLPQEVSR---LKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICI 168
LNL+N L P+ +R L +T ++ N+ +P C L +L L L +N L C+
Sbjct: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
Query: 169 PEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFY 227
+ L L L L+RN + +LP +C L LR+L ++ N + P L LR+
Sbjct: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIVSNNKLGALPPDIGTLGSLRQLD 165
Query: 228 CEGNPL 233
N L
Sbjct: 166 VSSNEL 171
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 89.7 bits (221), Expect = 3e-18
Identities = 75/248 (30%), Positives = 115/248 (46%), Gaps = 17/248 (6%)
Query: 3 ERLLIKALSGGKNTKIITLNGK------KMTKMPSALGKLPGLKTLV---LQ----NNLI 49
E L + +N + I ++G K+ ++ S L KLP + T V LQ NN
Sbjct: 519 EELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEG 578
Query: 50 PK--VCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPG-ACDGL 106
K V L + LT L L LE +P + L +L+ + L N + + L
Sbjct: 579 TKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHL 638
Query: 107 QNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLI 166
L L L NH+ +P ++ L +L + +N N++ IP +L + L L L++N L
Sbjct: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
Query: 167 CIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL-KLRE 225
+P +I L+ LQ L + N I LP EL +KLR L + N++Q PS +L L +
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758
Query: 226 FYCEGNPL 233
GN L
Sbjct: 759 IELRGNRL 766
Score = 76.6 bits (187), Expect = 3e-14
Identities = 57/212 (26%), Positives = 102/212 (48%), Gaps = 12/212 (5%)
Query: 6 LIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTL 65
L K + TK+I LN K K+ L L L + ++ + +L L +
Sbjct: 569 LQKLSINNEGTKLIVLNSLK---------KMANLTELELIRCDLERIPHSIFSLHNLQEI 619
Query: 66 NLGNNLLEEVPE--EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123
+L +N L+ + E ++L L L L N I + P L NL L LN N + ++P
Sbjct: 620 DLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIA-YIPIQIGNLTNLERLYLNRNKIEKIP 678
Query: 124 QEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLL 183
++ + L Y+ +++N L +P ++ L+NL L + N++ +P E+ +KL+ L L
Sbjct: 679 TQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHL 738
Query: 184 ARNNIGVLPEELCDLKKLRILDIAGNIIQIFP 215
N + LP + +L L +++ GN ++ P
Sbjct: 739 GNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
Score = 72.4 bits (176), Expect = 6e-13
Identities = 51/159 (32%), Positives = 80/159 (50%), Gaps = 3/159 (1%)
Query: 39 LKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRF 98
L L L N I + ++ NLT L L L N +E++P ++ Y L+ L LS N + F
Sbjct: 641 LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT-F 699
Query: 99 APGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVEL 158
P LQNL L + N + LP E+ + + L + + N L S+P + L NL ++
Sbjct: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQI 759
Query: 159 QLNYNQLICIPEEIKF--LKKLQKLLLARNNIGVLPEEL 195
+L N+L C+P E+ L K L++ + LP E+
Sbjct: 760 ELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 60.1 bits (144), Expect = 3e-09
Identities = 65/245 (26%), Positives = 105/245 (42%), Gaps = 60/245 (24%)
Query: 29 MPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQ-LTTLNLGNNLLEEVPEEMKYLTSLKN 87
+P ++ +L GLK L L + P L L + L L++ ++E+P + L +L+
Sbjct: 461 IPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEE 520
Query: 88 LHLSGNRIC---RFAPGACDG---LQNLILLNLNNNHLTQLPQEVS-------------- 127
LHL+GN R+ DG L+ L +L L +N L++LPQ V+
Sbjct: 521 LHLTGNLSAENNRYI--VIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNE 577
Query: 128 -----------RLKSLTYMSINYNQLASIPRELCFLENLVELQLN--------------- 161
++ +LT + + L IP + L NL E+ L
Sbjct: 578 GTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQH 637
Query: 162 ----------YNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNII 211
YN + IP +I L L++L L RN I +P +L +KLR LD++ N +
Sbjct: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
Query: 212 QIFPS 216
P+
Sbjct: 698 TFLPA 702
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 89.7 bits (221), Expect = 3e-18
Identities = 75/248 (30%), Positives = 115/248 (46%), Gaps = 17/248 (6%)
Query: 3 ERLLIKALSGGKNTKIITLNGK------KMTKMPSALGKLPGLKTLV---LQ----NNLI 49
E L + +N + I ++G K+ ++ S L KLP + T V LQ NN
Sbjct: 519 EELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEG 578
Query: 50 PK--VCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPG-ACDGL 106
K V L + LT L L LE +P + L +L+ + L N + + L
Sbjct: 579 TKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHL 638
Query: 107 QNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLI 166
L L L NH+ +P ++ L +L + +N N++ IP +L + L L L++N L
Sbjct: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
Query: 167 CIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL-KLRE 225
+P +I L+ LQ L + N I LP EL +KLR L + N++Q PS +L L +
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758
Query: 226 FYCEGNPL 233
GN L
Sbjct: 759 IELRGNRL 766
Score = 76.6 bits (187), Expect = 3e-14
Identities = 57/212 (26%), Positives = 102/212 (48%), Gaps = 12/212 (5%)
Query: 6 LIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTL 65
L K + TK+I LN K K+ L L L + ++ + +L L +
Sbjct: 569 LQKLSINNEGTKLIVLNSLK---------KMANLTELELIRCDLERIPHSIFSLHNLQEI 619
Query: 66 NLGNNLLEEVPE--EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123
+L +N L+ + E ++L L L L N I + P L NL L LN N + ++P
Sbjct: 620 DLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIA-YIPIQIGNLTNLERLYLNRNKIEKIP 678
Query: 124 QEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLL 183
++ + L Y+ +++N L +P ++ L+NL L + N++ +P E+ +KL+ L L
Sbjct: 679 TQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHL 738
Query: 184 ARNNIGVLPEELCDLKKLRILDIAGNIIQIFP 215
N + LP + +L L +++ GN ++ P
Sbjct: 739 GNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
Score = 72.4 bits (176), Expect = 6e-13
Identities = 51/159 (32%), Positives = 80/159 (50%), Gaps = 3/159 (1%)
Query: 39 LKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRF 98
L L L N I + ++ NLT L L L N +E++P ++ Y L+ L LS N + F
Sbjct: 641 LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT-F 699
Query: 99 APGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVEL 158
P LQNL L + N + LP E+ + + L + + N L S+P + L NL ++
Sbjct: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQI 759
Query: 159 QLNYNQLICIPEEIKF--LKKLQKLLLARNNIGVLPEEL 195
+L N+L C+P E+ L K L++ + LP E+
Sbjct: 760 ELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 60.1 bits (144), Expect = 3e-09
Identities = 65/245 (26%), Positives = 105/245 (42%), Gaps = 60/245 (24%)
Query: 29 MPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQ-LTTLNLGNNLLEEVPEEMKYLTSLKN 87
+P ++ +L GLK L L + P L L + L L++ ++E+P + L +L+
Sbjct: 461 IPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEE 520
Query: 88 LHLSGNRIC---RFAPGACDG---LQNLILLNLNNNHLTQLPQEVS-------------- 127
LHL+GN R+ DG L+ L +L L +N L++LPQ V+
Sbjct: 521 LHLTGNLSAENNRYI--VIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNE 577
Query: 128 -----------RLKSLTYMSINYNQLASIPRELCFLENLVELQLN--------------- 161
++ +LT + + L IP + L NL E+ L
Sbjct: 578 GTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQH 637
Query: 162 ----------YNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNII 211
YN + IP +I L L++L L RN I +P +L +KLR LD++ N +
Sbjct: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
Query: 212 QIFPS 216
P+
Sbjct: 698 TFLPA 702
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 89.7 bits (221), Expect = 3e-18
Identities = 75/248 (30%), Positives = 115/248 (46%), Gaps = 17/248 (6%)
Query: 3 ERLLIKALSGGKNTKIITLNGK------KMTKMPSALGKLPGLKTLV---LQ----NNLI 49
E L + +N + I ++G K+ ++ S L KLP + T V LQ NN
Sbjct: 519 EELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEG 578
Query: 50 PK--VCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPG-ACDGL 106
K V L + LT L L LE +P + L +L+ + L N + + L
Sbjct: 579 TKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHL 638
Query: 107 QNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLI 166
L L L NH+ +P ++ L +L + +N N++ IP +L + L L L++N L
Sbjct: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
Query: 167 CIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL-KLRE 225
+P +I L+ LQ L + N I LP EL +KLR L + N++Q PS +L L +
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758
Query: 226 FYCEGNPL 233
GN L
Sbjct: 759 IELRGNRL 766
Score = 76.6 bits (187), Expect = 3e-14
Identities = 57/212 (26%), Positives = 102/212 (48%), Gaps = 12/212 (5%)
Query: 6 LIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTL 65
L K + TK+I LN K K+ L L L + ++ + +L L +
Sbjct: 569 LQKLSINNEGTKLIVLNSLK---------KMANLTELELIRCDLERIPHSIFSLHNLQEI 619
Query: 66 NLGNNLLEEVPE--EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123
+L +N L+ + E ++L L L L N I + P L NL L LN N + ++P
Sbjct: 620 DLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIA-YIPIQIGNLTNLERLYLNRNKIEKIP 678
Query: 124 QEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLL 183
++ + L Y+ +++N L +P ++ L+NL L + N++ +P E+ +KL+ L L
Sbjct: 679 TQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHL 738
Query: 184 ARNNIGVLPEELCDLKKLRILDIAGNIIQIFP 215
N + LP + +L L +++ GN ++ P
Sbjct: 739 GNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
Score = 72.4 bits (176), Expect = 6e-13
Identities = 51/159 (32%), Positives = 80/159 (50%), Gaps = 3/159 (1%)
Query: 39 LKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRF 98
L L L N I + ++ NLT L L L N +E++P ++ Y L+ L LS N + F
Sbjct: 641 LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT-F 699
Query: 99 APGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVEL 158
P LQNL L + N + LP E+ + + L + + N L S+P + L NL ++
Sbjct: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQI 759
Query: 159 QLNYNQLICIPEEIKF--LKKLQKLLLARNNIGVLPEEL 195
+L N+L C+P E+ L K L++ + LP E+
Sbjct: 760 ELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 60.1 bits (144), Expect = 3e-09
Identities = 65/245 (26%), Positives = 105/245 (42%), Gaps = 60/245 (24%)
Query: 29 MPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQ-LTTLNLGNNLLEEVPEEMKYLTSLKN 87
+P ++ +L GLK L L + P L L + L L++ ++E+P + L +L+
Sbjct: 461 IPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEE 520
Query: 88 LHLSGNRIC---RFAPGACDG---LQNLILLNLNNNHLTQLPQEVS-------------- 127
LHL+GN R+ DG L+ L +L L +N L++LPQ V+
Sbjct: 521 LHLTGNLSAENNRYI--VIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNE 577
Query: 128 -----------RLKSLTYMSINYNQLASIPRELCFLENLVELQLN--------------- 161
++ +LT + + L IP + L NL E+ L
Sbjct: 578 GTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQH 637
Query: 162 ----------YNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNII 211
YN + IP +I L L++L L RN I +P +L +KLR LD++ N +
Sbjct: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
Query: 212 QIFPS 216
P+
Sbjct: 698 TFLPA 702
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 89.0 bits (219), Expect = 6e-18
Identities = 69/233 (29%), Positives = 120/233 (51%), Gaps = 27/233 (11%)
Query: 2 TERLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQ 61
T R L +AL ++ I++L+G+K+ P + +LT
Sbjct: 76 TVRSLDRALEEAGSSGILSLSGRKLRDFPGSG-----------------------YDLTD 112
Query: 62 LTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQ 121
T +L N E+P ++ L+ L+L N I + P A LQ L LN++ N L+
Sbjct: 113 TTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCI-KTIPEAIKNLQMLTYLNISRNLLST 171
Query: 122 LPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKL 181
LP+ + L L + ++ N+L SIP E+ L++L+EL ++ N++ +P+++ L L++L
Sbjct: 172 LPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLREL 230
Query: 182 LLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPL 233
+ RNN+ VLP+EL DL ++ LD + N + P ++ L L+ + NPL
Sbjct: 231 NIRRNNLHVLPDELGDLPLVK-LDFSCNKVTEIPVCYRKLHHLQVIILDNNPL 282
Score = 52.0 bits (123), Expect = 8e-07
Identities = 38/140 (27%), Positives = 73/140 (52%), Gaps = 6/140 (4%)
Query: 14 KNTKIIT---LNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNN 70
KN +++T ++ ++ +P L LP LK LV+ NN + + E+ L L L++ N
Sbjct: 154 KNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISCN 212
Query: 71 LLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLK 130
++ +P++M L SL+ L++ N + P L L+ L+ + N +T++P +L
Sbjct: 213 EIQVLPQQMGKLHSLRELNIRRNNL-HVLPDELGDLP-LVKLDFSCNKVTEIPVCYRKLH 270
Query: 131 SLTYMSINYNQLASIPRELC 150
L + ++ N L P ++C
Sbjct: 271 HLQVIILDNNPLQVPPAQIC 290
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 88.2 bits (217), Expect = 1e-17
Identities = 67/225 (29%), Positives = 111/225 (49%), Gaps = 15/225 (6%)
Query: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
+ +K++ LN K K+ LK+L L + + ++ + +L L L+L N L+
Sbjct: 571 EGSKLVVLNNLK---------KMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLK 621
Query: 74 EVPE--EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKS 131
V E ++L +L L L N I + P L NL L+L++N++ LP ++
Sbjct: 622 TVEEIISFQHLQNLSCLKLWHNNIA-YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTK 680
Query: 132 LTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVL 191
L Y+ ++YN L IP E+ +L NL + N + +P+ + KKLQ LLL +N++ L
Sbjct: 681 LHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNL 740
Query: 192 PEELCDLKKLRILDIAGNIIQIFP---SGFQDLKLREFYCEGNPL 233
+ +L L L++ GN ++ P G Q LK E N L
Sbjct: 741 SPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLL 785
Score = 85.1 bits (209), Expect = 8e-17
Identities = 63/201 (31%), Positives = 103/201 (51%), Gaps = 8/201 (3%)
Query: 14 KNTKIITLNGKKMTKMPSALGKL-PGLKTLVLQNN---LIPKVCPELCNLTQLTTLNLGN 69
KN + + L ++++P + L P L+ L L N L+ V L + L +L L +
Sbjct: 538 KNLRTLYLKSS-LSRIPQVVTDLLPSLQKLSLDNEGSKLV--VLNNLKKMVNLKSLELIS 594
Query: 70 NLLEEVPEEMKYLTSLKNLHLSGNRICRFAPG-ACDGLQNLILLNLNNNHLTQLPQEVSR 128
LE +P + L +L L L N + + LQNL L L +N++ +P ++
Sbjct: 595 CDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGA 654
Query: 129 LKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNI 188
L +L +S+++N + ++P +L L L L+YN L IPEEI++L LQ + NNI
Sbjct: 655 LSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNI 714
Query: 189 GVLPEELCDLKKLRILDIAGN 209
+LP+ L KKL+ L + N
Sbjct: 715 EMLPDGLFQCKKLQCLLLGKN 735
Score = 42.0 bits (97), Expect = 8e-04
Identities = 34/120 (28%), Positives = 59/120 (49%), Gaps = 7/120 (5%)
Query: 119 LTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKL 178
L LP V L + +S+ +P + L NL EL++ ++ L+ + FL++
Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
Query: 179 QKLL-LARNNIGVLPEELCDLKKLRILDIAGNII-----QIFPSGFQDLK-LREFYCEGN 231
K+L L +G +P + LK L+ L ++G ++ + GFQDLK LR Y + +
Sbjct: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS 548
Score = 40.4 bits (93), Expect = 0.002
Identities = 37/117 (31%), Positives = 60/117 (51%), Gaps = 12/117 (10%)
Query: 106 LQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFL-ENLVELQLNYNQ 164
L + +L+L +LP VS+L +L + + ++ L L FL ENL L+L + +
Sbjct: 439 LTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTE 498
Query: 165 LICIPEEIKFLKKLQKLLLARNNIGVLPEELC--------DLKKLRILDIAGNIIQI 213
+ IP + LK L++L L+ VLPE+L DLK LR L + ++ +I
Sbjct: 499 MGKIPRWVFHLKNLKELYLSG---CVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRI 552
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 88.2 bits (217), Expect = 1e-17
Identities = 67/225 (29%), Positives = 111/225 (49%), Gaps = 15/225 (6%)
Query: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
+ +K++ LN K K+ LK+L L + + ++ + +L L L+L N L+
Sbjct: 571 EGSKLVVLNNLK---------KMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLK 621
Query: 74 EVPE--EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKS 131
V E ++L +L L L N I + P L NL L+L++N++ LP ++
Sbjct: 622 TVEEIISFQHLQNLSCLKLWHNNIA-YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTK 680
Query: 132 LTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVL 191
L Y+ ++YN L IP E+ +L NL + N + +P+ + KKLQ LLL +N++ L
Sbjct: 681 LHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNL 740
Query: 192 PEELCDLKKLRILDIAGNIIQIFP---SGFQDLKLREFYCEGNPL 233
+ +L L L++ GN ++ P G Q LK E N L
Sbjct: 741 SPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLL 785
Score = 85.1 bits (209), Expect = 8e-17
Identities = 63/201 (31%), Positives = 103/201 (51%), Gaps = 8/201 (3%)
Query: 14 KNTKIITLNGKKMTKMPSALGKL-PGLKTLVLQNN---LIPKVCPELCNLTQLTTLNLGN 69
KN + + L ++++P + L P L+ L L N L+ V L + L +L L +
Sbjct: 538 KNLRTLYLKSS-LSRIPQVVTDLLPSLQKLSLDNEGSKLV--VLNNLKKMVNLKSLELIS 594
Query: 70 NLLEEVPEEMKYLTSLKNLHLSGNRICRFAPG-ACDGLQNLILLNLNNNHLTQLPQEVSR 128
LE +P + L +L L L N + + LQNL L L +N++ +P ++
Sbjct: 595 CDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGA 654
Query: 129 LKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNI 188
L +L +S+++N + ++P +L L L L+YN L IPEEI++L LQ + NNI
Sbjct: 655 LSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNI 714
Query: 189 GVLPEELCDLKKLRILDIAGN 209
+LP+ L KKL+ L + N
Sbjct: 715 EMLPDGLFQCKKLQCLLLGKN 735
Score = 42.0 bits (97), Expect = 8e-04
Identities = 34/120 (28%), Positives = 59/120 (49%), Gaps = 7/120 (5%)
Query: 119 LTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKL 178
L LP V L + +S+ +P + L NL EL++ ++ L+ + FL++
Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
Query: 179 QKLL-LARNNIGVLPEELCDLKKLRILDIAGNII-----QIFPSGFQDLK-LREFYCEGN 231
K+L L +G +P + LK L+ L ++G ++ + GFQDLK LR Y + +
Sbjct: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS 548
Score = 40.4 bits (93), Expect = 0.002
Identities = 37/117 (31%), Positives = 60/117 (51%), Gaps = 12/117 (10%)
Query: 106 LQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFL-ENLVELQLNYNQ 164
L + +L+L +LP VS+L +L + + ++ L L FL ENL L+L + +
Sbjct: 439 LTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTE 498
Query: 165 LICIPEEIKFLKKLQKLLLARNNIGVLPEELC--------DLKKLRILDIAGNIIQI 213
+ IP + LK L++L L+ VLPE+L DLK LR L + ++ +I
Sbjct: 499 MGKIPRWVFHLKNLKELYLSG---CVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRI 552
>gi|63003903 leucine rich repeat containing 10 [Homo sapiens]
Length = 277
Score = 87.8 bits (216), Expect = 1e-17
Identities = 48/160 (30%), Positives = 91/160 (56%), Gaps = 2/160 (1%)
Query: 75 VPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTY 134
V +++ + K + LSG+++ RF C + L+ L L++NHL LP E+ +L++L
Sbjct: 21 VVRDLREMPLDKMVDLSGSQLRRFPLHVCS-FRELVKLYLSDNHLNSLPPELGQLQNLQI 79
Query: 135 MSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEE 194
+++++N ++P+ +C L+ L L L N+L +P E+ L+ L+ L + N + LP+
Sbjct: 80 LALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDV 139
Query: 195 LCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPL 233
+C+L L+ L N +++ P + L +LR + GN L
Sbjct: 140 VCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRL 179
Score = 81.3 bits (199), Expect = 1e-15
Identities = 55/184 (29%), Positives = 92/184 (50%), Gaps = 1/184 (0%)
Query: 33 LGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSG 92
L ++P K + L + + + +C+ +L L L +N L +P E+ L +L+ L L
Sbjct: 25 LREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDF 84
Query: 93 NRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFL 152
N C L+ L +L L NN L LP E+S L++L + I N L +P +C L
Sbjct: 85 NNFKALPQVVCT-LKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCEL 143
Query: 153 ENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQ 212
L L N L +P +++ L++L+ + L+ N + P L + L ++D+ N I+
Sbjct: 144 SLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIR 203
Query: 213 IFPS 216
FPS
Sbjct: 204 YFPS 207
Score = 68.2 bits (165), Expect = 1e-11
Identities = 46/166 (27%), Positives = 81/166 (48%), Gaps = 2/166 (1%)
Query: 21 LNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMK 80
L+ + +P LG+L L+ L L N + +C L QL L LGNN L ++P E+
Sbjct: 59 LSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELS 118
Query: 81 YLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYN 140
L +L+ L + N + + C+ L L L+ +N L LP ++ RL+ L + ++ N
Sbjct: 119 LLQNLRTLWIEANCLTQLPDVVCE-LSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGN 177
Query: 141 QLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARN 186
+L P L + L + +++N + P + L L+ ++ N
Sbjct: 178 RLTDFPTVLLHMPFLEVIDVDWNSIRYFP-SLAHLSSLKLVIYDHN 222
Score = 60.8 bits (146), Expect = 2e-09
Identities = 38/134 (28%), Positives = 72/134 (53%), Gaps = 2/134 (1%)
Query: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
K I+ L K+ +PS L L L+TL ++ N + ++ +C L+ L TL+ G+N L
Sbjct: 98 KQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALR 157
Query: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133
+P +++ L L+ + LSGNR+ F P + L +++++ N + P ++ L SL
Sbjct: 158 LLPGQLRRLQELRTIWLSGNRLTDF-PTVLLHMPFLEVIDVDWNSIRYFP-SLAHLSSLK 215
Query: 134 YMSINYNQLASIPR 147
+ ++N + P+
Sbjct: 216 LVIYDHNPCRNAPK 229
Score = 28.9 bits (63), Expect = 7.1
Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 1/77 (1%)
Query: 4 RLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLT 63
RLL L + + I L+G ++T P+ L +P L+ + + N I + P L +L+ L
Sbjct: 157 RLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSI-RYFPSLAHLSSLK 215
Query: 64 TLNLGNNLLEEVPEEMK 80
+ +N P+ K
Sbjct: 216 LVIYDHNPCRNAPKVAK 232
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 86.3 bits (212), Expect = 4e-17
Identities = 72/242 (29%), Positives = 114/242 (47%), Gaps = 28/242 (11%)
Query: 8 KALSGGKNTKIITLNGKKMTKMPSALG-KLPGLKTLVLQNNLIPKVCPELCNLTQLTTLN 66
+ L KN ++ L+ + +P+ L L L L L N + + P++ L L TL
Sbjct: 121 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV 180
Query: 67 L-GNNLLEEVPEEMKYLTSLKNLHL-SGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQ 124
L GN LL ++ +T+L+ LHL S R P + +GL NL ++L+ N LT++P+
Sbjct: 181 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE 240
Query: 125 EVSRLKSLTYMSINYNQ-----------------------LASIPRELCFLENLVELQLN 161
+ L SL ++++ NQ L S+P +C L L +L LN
Sbjct: 241 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN 300
Query: 162 YNQLIC--IPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQ 219
N+L +P I L L++ + A NN+ ++PE LC KLR L + N + P
Sbjct: 301 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH 360
Query: 220 DL 221
L
Sbjct: 361 FL 362
Score = 80.9 bits (198), Expect = 2e-15
Identities = 66/225 (29%), Positives = 107/225 (47%), Gaps = 29/225 (12%)
Query: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNN-LIPKVCPELCNLTQLTTLNLGN-------- 69
+ L+ ++ +P + +L L+TLVL N L+ +L +T L TL+L +
Sbjct: 156 LDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNL 215
Query: 70 -----------------NLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILL 112
N L VPE + L SL+ L+LS N+I + D ++ L
Sbjct: 216 PTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSL-CIDQWVHVETL 274
Query: 113 NLNNNHLTQLPQEVSRLKSLTYMSINYNQLA--SIPRELCFLENLVELQLNYNQLICIPE 170
NL+ N LT LP + +L L + +N N+L +P + L NL E N L +PE
Sbjct: 275 NLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPE 334
Query: 171 EIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFP 215
+ KL+KL+L +N++ LPE + L ++ +LD+ N + P
Sbjct: 335 SLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
Score = 74.7 bits (182), Expect = 1e-13
Identities = 55/166 (33%), Positives = 90/166 (54%), Gaps = 5/166 (3%)
Query: 76 PEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYM 135
PE +K +TSL+ L L+ +C + P LQ L L++++N+LT L E+S L SL +
Sbjct: 26 PENVKAMTSLRWLKLNRTGLC-YLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAI 84
Query: 136 SINYNQL--ASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPE 193
N L + +P ++ L++L L L++NQL P E++ K + L L+ N+I +P
Sbjct: 85 VARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPN 144
Query: 194 EL-CDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPLFLQQ 237
+L +L L LD++ N ++ P + L L+ GNPL Q
Sbjct: 145 QLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQ 190
Score = 74.7 bits (182), Expect = 1e-13
Identities = 56/196 (28%), Positives = 89/196 (45%), Gaps = 22/196 (11%)
Query: 2 TERLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQ 61
T+ L +L G N + L+ +T++P L LP L+ L L +N I ++ +
Sbjct: 211 TQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVH 270
Query: 62 LTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQ 121
+ TLNL N L +P + L+ LK L+L+ N++ DGL
Sbjct: 271 VETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKL------DFDGL--------------- 309
Query: 122 LPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKL 181
P + +L +L N L +P LC L +L LN N L+ +PE I FL +++ L
Sbjct: 310 -PSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVL 368
Query: 182 LLARNNIGVLPEELCD 197
+ N V+P + D
Sbjct: 369 DVRENPNLVMPPKPAD 384
Score = 62.4 bits (150), Expect = 6e-10
Identities = 46/154 (29%), Positives = 80/154 (51%), Gaps = 4/154 (2%)
Query: 59 LTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNL--ILLNLNN 116
+T L L L L +PEE+ L L++L +S N + G L +L I+ N+
Sbjct: 32 MTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLH-GELSSLPSLRAIVARANS 90
Query: 117 NHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKF-L 175
+ +P ++ +L L+ + +++NQL PREL +N++ L L++N + IP ++ L
Sbjct: 91 LKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINL 150
Query: 176 KKLQKLLLARNNIGVLPEELCDLKKLRILDIAGN 209
L L L+ N + LP ++ L L+ L + GN
Sbjct: 151 TDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGN 184
Score = 57.0 bits (136), Expect = 2e-08
Identities = 40/138 (28%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Query: 82 LTSLKNLHLSGNRICR-FAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYN 140
L ++ + LSGN + P + +L L LN L LP+E++ L+ L ++S+++N
Sbjct: 7 LPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHN 66
Query: 141 QLASIPRELCFLENLVELQLNYNQL--ICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198
L ++ EL L +L + N L +P++I L L L L+ N + P EL +
Sbjct: 67 NLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENA 126
Query: 199 KKLRILDIAGNIIQIFPS 216
K + +L+++ N I P+
Sbjct: 127 KNMLVLNLSHNSIDTIPN 144
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,478,327
Number of Sequences: 37866
Number of extensions: 583382
Number of successful extensions: 3393
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 184
Number of HSP's successfully gapped in prelim test: 71
Number of HSP's that attempted gapping in prelim test: 1474
Number of HSP's gapped (non-prelim): 854
length of query: 347
length of database: 18,247,518
effective HSP length: 103
effective length of query: 244
effective length of database: 14,347,320
effective search space: 3500746080
effective search space used: 3500746080
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.