Search of human proteins with 193083148

Search of human proteins with 193083148

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|193083148 cytochrome P450 family 2 subfamily C polypeptide
18 isoform 2 [Homo sapiens]
         (431 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   882   0.0  
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   775   0.0  
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   711   0.0  
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   632   0.0  
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   459   e-129
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   444   e-125
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   434   e-122
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   432   e-121
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   406   e-113
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   361   e-100
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   357   2e-98
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   352   3e-97
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   305   5e-83
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   304   1e-82
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   260   2e-69
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   247   1e-65
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   244   8e-65
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   241   1e-63
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   206   3e-53
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   201   1e-51
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   199   5e-51
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   185   8e-47
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  174   2e-43
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   126   3e-29
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   107   2e-23
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   100   3e-21
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid...    99   1e-20
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...    91   2e-18
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...    90   5e-18
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...    89   8e-18

>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  882 bits (2278), Expect = 0.0
 Identities = 431/431 (100%), Positives = 431/431 (100%)

Query: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60
           MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV
Sbjct: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60

Query: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120
           YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW
Sbjct: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120

Query: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
           KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180

Query: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQEKHNQQSEFTVESLIATVTDMFGAGT 240
           VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQEKHNQQSEFTVESLIATVTDMFGAGT
Sbjct: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQEKHNQQSEFTVESLIATVTDMFGAGT 240

Query: 241 ETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYI 300
           ETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYI
Sbjct: 241 ETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYI 300

Query: 301 DLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNF 360
           DLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNF
Sbjct: 301 DLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNF 360

Query: 361 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRV 420
           KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRV
Sbjct: 361 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRV 420

Query: 421 PPLYQLCFIPV 431
           PPLYQLCFIPV
Sbjct: 421 PPLYQLCFIPV 431


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  775 bits (2002), Expect = 0.0
 Identities = 401/490 (81%), Positives = 411/490 (83%), Gaps = 59/490 (12%)

Query: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60
           MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV
Sbjct: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60

Query: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120
           YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW
Sbjct: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120

Query: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAP------ 174
           KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAP      
Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180

Query: 175 -----------------------------------CNVICSVIFH---------DRFDYK 190
                                              CN   ++I +         + F Y 
Sbjct: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI 240

Query: 191 DQRFLNLMEKFNENLRILSS---------PWIQEKHNQQSEFTVESLIATVTDMFGAGTE 241
               L  +++  E+L + S+            QEKHNQQSEFTVESLIATVTDMFGAGTE
Sbjct: 241 KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE 300

Query: 242 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 301
           TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID
Sbjct: 301 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 360

Query: 302 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 361
           LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK
Sbjct: 361 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 420

Query: 362 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 421
           KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP
Sbjct: 421 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 480

Query: 422 PLYQLCFIPV 431
           PLYQLCFIPV
Sbjct: 481 PLYQLCFIPV 490


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  711 bits (1836), Expect = 0.0
 Identities = 351/490 (71%), Positives = 391/490 (79%), Gaps = 59/490 (12%)

Query: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60
           MDP V LVLCLSCL LLS+WRQSSGRG+LP GPTPLP+IGNILQ+D+KD+SKSLTN SK+
Sbjct: 1   MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI 60

Query: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120
           YGPVFT+YFGL+ +VVLHGYE VKEALID GEEFSGRG FP+AE+ N+G GI+FSNGKRW
Sbjct: 61  YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW 120

Query: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
           KEIRRF LMTLRNFGMGKRSIEDRVQEEARCLVEELRKT ASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 181 VIFHDRFDYKDQRFLNLME--------------------------------KFNENLRIL 208
           +IF  RFDYKDQ+FLNLME                                K  +NL  +
Sbjct: 181 IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM 240

Query: 209 SSPWIQ---------------------------EKHNQQSEFTVESLIATVTDMFGAGTE 241
            S  ++                           EK NQQSEFT+E+L+ T  D+ GAGTE
Sbjct: 241 ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE 300

Query: 242 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 301
           TTSTTLRY LLLLLK+PEVTAKVQEEIE V+GRNRSPCMQDR HMPYTDAVVHE+QRYID
Sbjct: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID 360

Query: 302 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 361
           L+PT+LPHAVTCDVKF+NYLIPKGTTI+TSLTSVLH++KEFPNPEMFDP HFLD+ GNFK
Sbjct: 361 LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK 420

Query: 362 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 421
           KS+YFMPFSAGKR+C+GEGLARMELFLFLT ILQNFNLKS +DPKD+D TP+ N F  VP
Sbjct: 421 KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480

Query: 422 PLYQLCFIPV 431
           P YQLCFIPV
Sbjct: 481 PFYQLCFIPV 490


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  632 bits (1631), Expect = 0.0
 Identities = 332/491 (67%), Positives = 372/491 (75%), Gaps = 61/491 (12%)

Query: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60
           MD  V LVLCLSCL LLSLWRQSSGRG+LP GPTPLP+IGNILQ+ +KD+SKSLTN SKV
Sbjct: 1   MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60

Query: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120
           YGPVFT+YFGLKPIVVLHGYEAVKEALID GEEFSGRG FP+AE+ N+G GI+FSNGK+W
Sbjct: 61  YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120

Query: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNA-----------SPC----- 164
           KEIRRF LMTLRNFGMGKRSIEDRVQEEARCLVEELRKT A           +PC     
Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 165 ----------DPTFI-----------LGCAPCNVICSVIFHDRFDY---------KDQRF 194
                     D  F+           +  +P   IC+  F    DY         K+  F
Sbjct: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNN-FSPIIDYFPGTHNKLLKNVAF 239

Query: 195 LN--LMEKFNENLRILSSPWIQ------------EKHNQQSEFTVESLIATVTDMFGAGT 240
           +   ++EK  E+   +     Q            EKHNQ SEFT+ESL  T  D+FGAGT
Sbjct: 240 MKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGT 299

Query: 241 ETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYI 300
           ETTSTTLRY LLLLLK+PEVTAKVQEEIE V+GRNRSPCMQDRSHMPYTDAVVHE+QRYI
Sbjct: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYI 359

Query: 301 DLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNF 360
           DLLPT+LPHAVTCD+KF+NYLIPKGTTI+ SLTSVLH++KEFPNPEMFDP HFLD+ GNF
Sbjct: 360 DLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNF 419

Query: 361 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRV 420
           KKS YFMPFSAGKR+C+GE LA MELFLFLT+ILQNFNLKS VDPK++D TP+ N F  V
Sbjct: 420 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASV 479

Query: 421 PPLYQLCFIPV 431
           PP YQLCFIPV
Sbjct: 480 PPFYQLCFIPV 490


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  459 bits (1182), Expect = e-129
 Identities = 236/485 (48%), Positives = 311/485 (64%), Gaps = 60/485 (12%)

Query: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
           VAL++  + L L+S+WRQ      LP GP PLPIIGN+ QL++K++ KS T  ++ +GPV
Sbjct: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67

Query: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124
           FT+Y G + +VV+HGY+AVKEAL+D+ +EFSGRG  P A   ++  GI+F+NG  WK+IR
Sbjct: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIR 126

Query: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVI-- 182
           RF L TLRN+GMGK+  E R+Q EA  L+E LRKT   P DPTF++GCAPCNVI  ++  
Sbjct: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186

Query: 183 ----------------FHDRFDYKDQRFLNLMEKFNENLRILSSP--------------- 211
                           F++ F      +L L   F   L  L                  
Sbjct: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246

Query: 212 --------------------------WIQEKHNQQSEFTVESLIATVTDMFGAGTETTST 245
                                       +EKH+ +  +T++ +  TV D+F AGTETTST
Sbjct: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 306

Query: 246 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 305
           TLRYGLL+L+KYPE+  K+ EEI+ V+G +R P ++DR  MPY DAVVHEIQR+I L+P+
Sbjct: 307 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366

Query: 306 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 365
           NLPH  T D  F+ YLIPKGT ++ +L SVL++++EFP+PE F P HFL+++G FK SDY
Sbjct: 367 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426

Query: 366 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 425
           F PFS GKR+C GEGLARMELFL L  ILQ+FNLK  VDPKDID++PI   FG +PP Y+
Sbjct: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486

Query: 426 LCFIP 430
           LC IP
Sbjct: 487 LCVIP 491


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  444 bits (1141), Expect = e-125
 Identities = 231/485 (47%), Positives = 304/485 (62%), Gaps = 59/485 (12%)

Query: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
           V L+ CL+ + L+S+WRQ   RG+LP GPTPLP IGN LQL+ + M  SL   S+ YGPV
Sbjct: 9   VTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68

Query: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124
           FT++ G + +VVL G++AVKEAL+D  EEFSGRG     + + KG G+ FSNG+R K++R
Sbjct: 69  FTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLR 128

Query: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184
           RF + TLR FG+GKR IE+R+QEEA  L++ LR T+ +  DPTF L     NVI S++F 
Sbjct: 129 RFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFG 188

Query: 185 DRFDYKDQRFLNLM------------------EKFNENLRILSSPWIQ------------ 214
           DRFDY+D+ FL+L+                  E F+  ++ L  P  Q            
Sbjct: 189 DRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFI 248

Query: 215 -----------------------------EKHNQQSEFTVESLIATVTDMFGAGTETTST 245
                                        E+ N  +EF +++L+ T  ++F AGTET ST
Sbjct: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVST 308

Query: 246 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 305
           TLRYG LLL+K+PEV AKV EEI+ V+G+NR P  +DR+ MPYT+AV+HEIQR+ D+LP 
Sbjct: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPM 368

Query: 306 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 365
            L H V  D KF+++ +PKGT +   L SVL + + F NP  F+P HFLDK G FKKSD 
Sbjct: 369 GLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDA 428

Query: 366 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 425
           F+PFS GKR C GEGLARMELFLF TTI+QNF  KS   PKDID++P    F  +P  Y 
Sbjct: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYT 488

Query: 426 LCFIP 430
           + F+P
Sbjct: 489 MSFLP 493


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  434 bits (1117), Expect = e-122
 Identities = 225/485 (46%), Positives = 306/485 (63%), Gaps = 59/485 (12%)

Query: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
           VAL++CL+ + L+S+W+Q   +G+LP GPTPLP IGN LQL+ + M  SL   S+ YGPV
Sbjct: 9   VALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68

Query: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124
           FT++ G + +VVL G++AV+EAL+D  EEFSGRG     + V KG G++FSNG+R K++R
Sbjct: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLR 128

Query: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184
           RF + TLR+FG+GKR IE+R+QEEA  L++ LR T  +  DPTF L     NVI S++F 
Sbjct: 129 RFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFG 188

Query: 185 DRFDYKDQRFLNLM------------------EKFNENLRILSSPWIQ------------ 214
           DRFDYKD+ FL+L+                  E F+  ++ L  P  Q            
Sbjct: 189 DRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFI 248

Query: 215 -----------------------------EKHNQQSEFTVESLIATVTDMFGAGTETTST 245
                                        E+ N  +EF +++L+ T  ++F  GTET ST
Sbjct: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVST 308

Query: 246 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 305
           TLRYG LLL+K+PEV AKV EEI+ V+G+NR P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPM 368

Query: 306 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 365
           +L   V  D KF+++ +PKGT +   L SVL +   F NP+ F+P HFL++ G FKKSD 
Sbjct: 369 SLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDA 428

Query: 366 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 425
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS   PKDID++P    F  +P  Y 
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYT 488

Query: 426 LCFIP 430
           + F+P
Sbjct: 489 MSFLP 493


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  432 bits (1110), Expect = e-121
 Identities = 223/485 (45%), Positives = 305/485 (62%), Gaps = 59/485 (12%)

Query: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
           VAL+ CL+ + L+S+W+Q   RG+LP GPTPLP IGN LQL+ + +  S+  FS+ YGPV
Sbjct: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPV 68

Query: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124
           FT++ G + +VVL G++AV+EAL+D  EEFSGRG     + V KG G+ FSNG+R K++ 
Sbjct: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLL 128

Query: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184
           RF + TLR+FG+GKR IE+R+QEE+  L+E +R T+ +  DPTF L     NVI S++F 
Sbjct: 129 RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 188

Query: 185 DRFDYKDQRFLNLM------------------EKFNENLRILSSPWIQ------------ 214
           DRFDY+D+ FL+L+                  E F+  ++ L  P  Q            
Sbjct: 189 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 248

Query: 215 -----------------------------EKHNQQSEFTVESLIATVTDMFGAGTETTST 245
                                        E+ N  +EF +++L+ +  ++F AGTET ST
Sbjct: 249 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 308

Query: 246 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 305
           TLRYG LLL+K+PEV AKV EEI+ V+G+NR P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 368

Query: 306 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 365
           +L   V  D KF+++ +PKGT +   L SVL +   F NP+ F+P HFLD  G FKKSD 
Sbjct: 369 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 428

Query: 366 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 425
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS   PKDID++P    F  +P  Y 
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 488

Query: 426 LCFIP 430
           + F+P
Sbjct: 489 MSFLP 493


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  406 bits (1043), Expect = e-113
 Identities = 213/490 (43%), Positives = 294/490 (60%), Gaps = 60/490 (12%)

Query: 1   MDPAVALVLCL-SCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSK 59
           M+ +V L L L + L LL + R  +   RLP GP PLP++GN+LQ+D + + KS   F +
Sbjct: 1   MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE 60

Query: 60  VYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKR 119
            YG VFTV+ G +P+V+L G EA++EAL+D  E FSGRG   + +   +G G++F+NG R
Sbjct: 61  KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR 120

Query: 120 WKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVIC 179
           WK +RRF + T+R+FGMGKRS+E+R+QEEA+CL+EELRK+  +  DPTF+      N+IC
Sbjct: 121 WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC 180

Query: 180 SVI------------------FHDRFDYKDQRFLNLMEKFNENLRILSSPWIQ------- 214
           S++                  F+  F      F  L E F+  L+       Q       
Sbjct: 181 SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE 240

Query: 215 ----------------------------------EKHNQQSEFTVESLIATVTDMFGAGT 240
                                             EK N  SEF+ ++L      +F AGT
Sbjct: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300

Query: 241 ETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYI 300
           ETTSTTLRYG LL+LKYP V  +V  EIE V+G +R P + DR+ MPYT+AV++EIQR+ 
Sbjct: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360

Query: 301 DLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNF 360
           DLLP  +PH VT    F+ Y+IPK T +   L++ LH+   F  P+ F+P HFLD +G  
Sbjct: 361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420

Query: 361 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRV 420
           KK++ F+PFS GKR+C+GEG+AR ELFLF TTILQNF++ S V P+DID+TP     G++
Sbjct: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI 480

Query: 421 PPLYQLCFIP 430
           PP YQ+ F+P
Sbjct: 481 PPTYQIRFLP 490


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  361 bits (926), Expect = e-100
 Identities = 171/218 (78%), Positives = 191/218 (87%)

Query: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60
           M+P V LVLCLS + L SLWRQS  R +LP GPTPLPIIGN+LQ+DVKD+ KS TNFSKV
Sbjct: 1   MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60

Query: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120
           YGPVFTVYFG+ PIVV HGYEAVKEALID+GEEFSGRG+ P+++++ KGLGI+ SNGKRW
Sbjct: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW 120

Query: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
           KEIRRF L TLRNFGMGKRSIEDRVQEEA CLVEELRKT ASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQEKHN 218
           V+F  RFDYKDQ FL LM++FNEN RIL+SPWIQ  +N
Sbjct: 181 VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNN 218



 Score =  354 bits (909), Expect = 8e-98
 Identities = 169/218 (77%), Positives = 192/218 (88%)

Query: 214 QEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVG 273
           QEK NQ+SEF +E+L+ TV D+F AGTETTSTTLRYGLLLLLK+PEVTAKVQEEI+ V+G
Sbjct: 273 QEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIG 332

Query: 274 RNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLT 333
           R+RSPCMQDRSHMPYTDAVVHEIQRY DL+PT +PHAVT D KF+NYLIPKGTTI+  LT
Sbjct: 333 RHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLT 392

Query: 334 SVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTI 393
           SVLH+DKEFPNP +FDPGHFLDK+GNFKKSDYFMPFSAGKR+C GEGLARMELFLFLTTI
Sbjct: 393 SVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTI 452

Query: 394 LQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIPV 431
           LQNFNLKS  D K+++ T +      +PP YQ+CFIPV
Sbjct: 453 LQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV 490


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  357 bits (915), Expect = 2e-98
 Identities = 197/483 (40%), Positives = 277/483 (57%), Gaps = 62/483 (12%)

Query: 6   ALVLCLSCLFLLSLWRQSS-GRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
           AL+L L+ L LL+L    +  RG LP GPTPLP++GN+LQL    +   L   SK YGPV
Sbjct: 8   ALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPV 67

Query: 65  FTVYFG-LKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEI 123
           FT+Y G  +P+VVL G EAV+EAL    EEFSGRG+  + E    G G+ FSNG+RW+++
Sbjct: 68  FTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQL 127

Query: 124 RRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIF 183
           R+F ++ LR+ GMGKR  E+ +Q EARCLVE  + T   P DP+ +L  A  NV+CS++F
Sbjct: 128 RKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLF 187

Query: 184 HDRFDYKDQRFLNLM------------------EKFNENLRILSSPWIQ----------- 214
             RF Y+D+ F  ++                  E F+  LR L  P  Q           
Sbjct: 188 GLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAF 247

Query: 215 -------------------------------EKHNQQSEFTVESLIATVTDMFGAGTETT 243
                                          E+ N  +EFT ++++ TV  +  AGT T 
Sbjct: 248 TVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTV 307

Query: 244 STTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLL 303
           STT+ Y LLLL+KYP V   V+EE+   +G  ++P + DR+ +PYTDAV+HE QR + L+
Sbjct: 308 STTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALV 367

Query: 304 PTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKS 363
           P  +P  +    +F+ Y +P+GT +   L S+LH+   F +PE F+P  FLD  G F+K 
Sbjct: 368 PMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKH 427

Query: 364 DYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPL 423
           + F+PFS GKR+C+GEGLA+ ELFLF TTILQ F+L+S   P  + + P  +    +PP 
Sbjct: 428 EAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPA 487

Query: 424 YQL 426
           +QL
Sbjct: 488 FQL 490


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  352 bits (904), Expect = 3e-97
 Identities = 195/485 (40%), Positives = 268/485 (55%), Gaps = 110/485 (22%)

Query: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
           VAL+ CL+ + L+S+W+Q   RG+LP GPTPLP IGN LQL+ + +  S+   S+     
Sbjct: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ----- 63

Query: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124
                                                         G+ FSNG+R K++ 
Sbjct: 64  ----------------------------------------------GVAFSNGERAKQLL 77

Query: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184
           RF + TLR+FG+GKR IE+R+QEE+  L+E +R T+ +  DPTF L     NVI S++F 
Sbjct: 78  RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 137

Query: 185 DRFDYKDQRFLNLM------------------EKFNENLRILSSPWIQ------------ 214
           DRFDY+D+ FL+L+                  E F+  ++ L  P  Q            
Sbjct: 138 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 197

Query: 215 -----------------------------EKHNQQSEFTVESLIATVTDMFGAGTETTST 245
                                        E+ N  +EF +++L+ +  ++F AGTET ST
Sbjct: 198 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 257

Query: 246 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 305
           TLRYG LLL+K+PEV AKV EEI+ V+G+NR P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 258 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 317

Query: 306 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 365
           +L   V  D KF+++ +PKGT +   L SVL +   F NP+ F+P HFLD  G FKKSD 
Sbjct: 318 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 377

Query: 366 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 425
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS   PKDID++P    F  +P  Y 
Sbjct: 378 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 437

Query: 426 LCFIP 430
           + F+P
Sbjct: 438 MSFLP 442


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  305 bits (781), Expect = 5e-83
 Identities = 179/489 (36%), Positives = 264/489 (53%), Gaps = 69/489 (14%)

Query: 8   VLCLSCLFLLSLW-------RQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60
           +L L  L LL LW       +  S   R P GP PLP++GN+  L +    +SL   S+ 
Sbjct: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62

Query: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120
           YGPVFTV+ G +  VVL G+EAVKEAL   G+E + R    + + + +G GI FS+G RW
Sbjct: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122

Query: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
           +  R+F +  L + G+G+  + D++ +E +CL  +L      P  P  +LG AP N+  +
Sbjct: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181

Query: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSS---------PW------------------- 212
           ++F  RFDY+D  F++L+   +E + +L S         PW                   
Sbjct: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVR 241

Query: 213 ---------------------------IQEKHNQQSE--FTVESLIATVTDMFGAGTETT 243
                                      IQ+      E  F   + +A   DM  AGTETT
Sbjct: 242 AILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGTETT 301

Query: 244 STTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLL 303
           S TL++  LL+ ++P+V  +VQEE++ V+G  R+P ++D+  +PYT AV+HE+QR+I LL
Sbjct: 302 SATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLL 361

Query: 304 PTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKS 363
           P ++P     D +   +L+PKGT +I  LTSVL ++ ++  P  F+PGHFLD +G+F K 
Sbjct: 362 P-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKR 420

Query: 364 DYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL--KSQVDPKDIDITPIANAFGRVP 421
           + F+PFSAG+R+C+GE LAR ELFL    +LQ + L     V P  +D TP A AF   P
Sbjct: 421 EAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP-ARAFTMRP 479

Query: 422 PLYQLCFIP 430
               LC +P
Sbjct: 480 RAQALCAVP 488


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  304 bits (778), Expect = 1e-82
 Identities = 172/458 (37%), Positives = 250/458 (54%), Gaps = 67/458 (14%)

Query: 30  PSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALID 89
           P GP  LP +GN   +D +     +  F K YG +F++  G    V++ G   +KEALI 
Sbjct: 44  PPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIH 103

Query: 90  HGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEA 149
             + F  R   P+ E + K  G++ S+G+ WKE RRF L  LRNFG+GK+S+E+R+QEEA
Sbjct: 104 MDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEA 163

Query: 150 RCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILS 209
           + L E +++ N  P DP F +  A  N+ICS+ F +RF+Y+D  F  L++  +E   + +
Sbjct: 164 QHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEA 223

Query: 210 S---------PWIQ-------------------------EKH------------------ 217
           S         PWI                          +KH                  
Sbjct: 224 SKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLK 283

Query: 218 -------NQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIEC 270
                  N  S F  E+LI +  D+F AGTETTSTTLR+ LL +  YPE+  KVQ EI+ 
Sbjct: 284 EMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDR 343

Query: 271 VVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIIT 330
           V+G+ + P    R  MPYT+AV+HE+QR  +++P N+P  VT D     Y +PKGT I+T
Sbjct: 344 VIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILT 403

Query: 331 SLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFL 390
           +LT++  +  E+  P+ F+P HFL+ +G FKK + FMPFS GKR C+GE LAR ELF+F 
Sbjct: 404 NLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAFMPFSIGKRACLGEQLARTELFIFF 462

Query: 391 TTILQNFNLKSQVDPK-------DIDITPIANAFGRVP 421
           T+++Q F  +   + K        I I+P+++    VP
Sbjct: 463 TSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAVP 500


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  260 bits (664), Expect = 2e-69
 Identities = 158/456 (34%), Positives = 238/456 (52%), Gaps = 63/456 (13%)

Query: 6   ALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKS--LTNFSKVYGP 63
           AL L L  L +  L +Q    G  P GP  LP IGNI  L          +   S+VYG 
Sbjct: 17  ALFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGE 75

Query: 64  VFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSN-GKRWKE 122
           +F++  G    VVL+GY+ VKE L+   E F+ R   P+  K+ K  G+L S  G+ W +
Sbjct: 76  IFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVD 135

Query: 123 IRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVI 182
            RR  + + R FG G++S E ++ EE +   + +      P D   ++  A  N+   +I
Sbjct: 136 HRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLII 195

Query: 183 FHDRFDYKDQRFLNLMEKFNENLRILSS---------PWI-------------------- 213
           F +RF Y+D  F +++E F+EN+ + +S         PWI                    
Sbjct: 196 FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYD 255

Query: 214 ------------------------------QEKHNQQSEFTVESLIATVTDMFGAGTETT 243
                                         Q K++  S F+ E+LI +V ++  AGTETT
Sbjct: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315

Query: 244 STTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLL 303
           +  LR+ +L +  YP +  +VQ+EI+ ++G N  P   D+  MPYT+AV+HE+ R+ +++
Sbjct: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375

Query: 304 PTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKS 363
           P  + HA + D   + Y IPKGTT+IT+L SV  ++K + +PE+F P  FLD SG F K 
Sbjct: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435

Query: 364 DYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 399
           +  +PFS G+R C+GE LARME+FLF T +LQ F+L
Sbjct: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  247 bits (631), Expect = 1e-65
 Identities = 159/492 (32%), Positives = 240/492 (48%), Gaps = 87/492 (17%)

Query: 1   MDPAV-ALVLC-LSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNI---------------- 42
           +DP+  AL+LC L  L   S  R+   RG +P GPTP P++GN                 
Sbjct: 30  LDPSGGALLLCGLVALLGWSWLRRRRARG-IPPGPTPWPLVGNFGHVLLPPFLRRRSWLS 88

Query: 43  -------LQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFS 95
                  +   V      L + ++VYG +F+ + G   +VVL  + +V+EAL+   E FS
Sbjct: 89  SRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFS 148

Query: 96  GRGSFPVAEKVNKGLGILFSN-GKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVE 154
            R   P+   V K  G++F++ G  W++ R+F   TLR+FG+GK S+E ++ EE + +  
Sbjct: 149 DRPRVPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKA 208

Query: 155 ELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSS---- 210
           E++K    P  P  I+  A  N+ICS+ F  RFDY +  F  ++   +  L I  +    
Sbjct: 209 EMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVL 268

Query: 211 -----PWI---------------------------------------------------Q 214
                PW+                                                   +
Sbjct: 269 LVNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEE 328

Query: 215 EKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGR 274
            K+N  S F  E L   + D+F AGT+TT+ +L + LL +   P+V  KV EEIE V+G 
Sbjct: 329 RKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGA 388

Query: 275 NRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTS 334
           NR+P + D++ MPYT+A + E+QR   ++P  +PH  + +   + Y IPKGT I+ +L S
Sbjct: 389 NRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWS 448

Query: 335 VLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTIL 394
           V  +   +  PE F P  FLD  G   K + F+PF  GKR+CMGE LA+MELFL   +++
Sbjct: 449 VHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLM 508

Query: 395 QNFNLKSQVDPK 406
           Q+F      D K
Sbjct: 509 QSFAFALPEDSK 520


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  244 bits (624), Expect = 8e-65
 Identities = 114/217 (52%), Positives = 161/217 (74%)

Query: 214 QEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVG 273
           +EK +  S F +++L+ T  ++   GT+T STTL +  L L+KYP+V A+VQEEI+ VVG
Sbjct: 274 EEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVG 333

Query: 274 RNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLT 333
           R R P ++DR+ MPYTDAV+HE+QR+ D++P NLPH VT D  F+ +LIPKGT +IT L 
Sbjct: 334 RARLPALKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLN 393

Query: 334 SVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTI 393
           +V ++  +F  P+ F+P HFLD + +FKKS  FMPFSAG+R+C+GE LARMELFL+LT I
Sbjct: 394 TVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAI 453

Query: 394 LQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIP 430
           LQ+F+L+    P+DID+TP+++  G +P  +QLC  P
Sbjct: 454 LQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQLCLRP 490



 Score =  226 bits (577), Expect = 2e-59
 Identities = 111/209 (53%), Positives = 144/209 (68%)

Query: 4   AVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGP 63
           + A++L L  L  L L   S  +G+LP GP PL I+GN+L L  +DM  SLT  SK YG 
Sbjct: 5   STAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGS 64

Query: 64  VFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEI 123
           ++TV+ G + +VVL GY+AVKEAL+D GEEFSGRG +P      KG GI FS+G RWK +
Sbjct: 65  MYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVL 124

Query: 124 RRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIF 183
           R+F +  LRNFGMGKRSIE+R+ EE   L+ ELRKT   P DPTF+L  +  N+ICSV+F
Sbjct: 125 RQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLF 184

Query: 184 HDRFDYKDQRFLNLMEKFNENLRILSSPW 212
             RFDY D+R L ++   N+N +I+SSPW
Sbjct: 185 GSRFDYDDERLLTIIRLINDNFQIMSSPW 213


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  241 bits (614), Expect = 1e-63
 Identities = 151/447 (33%), Positives = 242/447 (54%), Gaps = 31/447 (6%)

Query: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
           +A+++ +  L +  + R+     R P GP PLP +GN+L +D ++         + +G V
Sbjct: 9   LAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDV 68

Query: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKE-- 122
           F++     P+VVL+G  AV+EAL+ HGE+ + R   P+ + +  G     S G+ ++   
Sbjct: 69  FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPR---SQGRPFRPNG 125

Query: 123 -IRRFCLMTLRNFGMGKRSIED--RVQEEARCLVEELRKTNASPCDPTFILGCAPCNVIC 179
            + +     + +   G+R   D  R         E L++ +    +   +L   P  +  
Sbjct: 126 LLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLRE---VLNAVPVLLHI 182

Query: 180 SVIFHDRFDYKDQRFLNLMEKFNENL---------RILSSPWIQE----KHNQQSEFTVE 226
             +      ++      L E   E+          R L+  ++ E    K N +S F  E
Sbjct: 183 PALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDE 242

Query: 227 SLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHM 286
           +L   V D+F AG  TTSTTL +GLLL++ +P+V  +VQ+EI+ V+G+ R P M D++HM
Sbjct: 243 NLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHM 302

Query: 287 PYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPE 346
           PYT AV+HE+QR+ D++P  + H  + D++ + + IPKGTT+IT+L+SVL ++  +  P 
Sbjct: 303 PYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPF 362

Query: 347 MFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK---SQV 403
            F P HFLD  G+F K + F+PFSAG+R C+GE LARMELFLF T++LQ+F+      Q 
Sbjct: 363 RFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQP 422

Query: 404 DPKDIDITPIANAFGRVPPLYQLCFIP 430
            P    +     AF   P  Y+LC +P
Sbjct: 423 RPSHHGVF----AFLVTPSPYELCAVP 445


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  206 bits (525), Expect = 3e-53
 Identities = 144/484 (29%), Positives = 226/484 (46%), Gaps = 82/484 (16%)

Query: 9   LCLSCLFLLSLWRQSSGRGRLPSG------PTPLPIIGNILQLDVKDMSKSLTNFSKVYG 62
           L  S +F L  W   + R ++P G      P   P+IG++L L  K+   +L+  S+ YG
Sbjct: 13  LLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYG 71

Query: 63  PVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFS--NGKRW 120
            V  +  G  P+VVL G + +++AL+  G++F GR        ++ G  + FS  +G  W
Sbjct: 72  DVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVW 131

Query: 121 KEIRRFCLMTLRNFGMGKRS-------IEDRVQEEARCLVEELRKTNASP--CDPTFILG 171
              RR     L++F +           +E+ V +EA  L+  L++  A P   +P   + 
Sbjct: 132 AARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVV 191

Query: 172 CAPCNVICSVIFHDRFDYKDQRFLNLMEKFNEN----------------LRILSSPWI-- 213
            +  NVIC++ F  R+D+  Q  L+L+   N N                LR L +P +  
Sbjct: 192 VSVTNVICAICFGRRYDHNHQELLSLVN-LNNNFGEVVGSGNPADFIPILRYLPNPSLNA 250

Query: 214 ---------------------------------------QEKH---NQQSEFTVESLIAT 231
                                                  QEK    N   + + E +I  
Sbjct: 251 FKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINI 310

Query: 232 VTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDA 291
           V D+FGAG +T +T + + L+ L+  P V  K+QEE++ V+GR+R P + DRSH+PY +A
Sbjct: 311 VLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEA 370

Query: 292 VVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPG 351
            + E  R+   +P  +PH+ T D   K + IPKG  +  +   + H+ K + NP  F P 
Sbjct: 371 FILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPE 430

Query: 352 HFLDKSGNFKK--SDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDID 409
            FL   G   K  S+  + F  GKR C+GE +AR E+FLFL  +LQ       +  K +D
Sbjct: 431 RFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VD 489

Query: 410 ITPI 413
           +TPI
Sbjct: 490 MTPI 493


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  201 bits (511), Expect = 1e-51
 Identities = 102/218 (46%), Positives = 146/218 (66%), Gaps = 7/218 (3%)

Query: 216 KHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRN 275
           K N +S F  E+L   V D+F AG  TTSTTL +GLLL++ +P+V  +VQ+EI+ V+G+ 
Sbjct: 283 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342

Query: 276 RSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSV 335
           R P M D++HMPYT AV+HE+QR+ D++P  + H  + D++ + + IPKGTT+IT+L+SV
Sbjct: 343 RRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSV 402

Query: 336 LHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQ 395
           L ++  +  P  F P HFLD  G+F K + F+PFSAG+R C+GE LARMELFLF T++LQ
Sbjct: 403 LKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQ 462

Query: 396 NFNLK---SQVDPKDIDITPIANAFGRVPPLYQLCFIP 430
           +F+      Q  P    +     AF   P  Y+LC +P
Sbjct: 463 HFSFSVPTGQPRPSHHGVF----AFLVTPSPYELCAVP 496



 Score =  132 bits (331), Expect = 8e-31
 Identities = 73/206 (35%), Positives = 113/206 (54%), Gaps = 4/206 (1%)

Query: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
           +A+++ +  L +  + R+     R P GP PLP +GN+L +D ++         + +G V
Sbjct: 9   LAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDV 68

Query: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKG---LGILFSN-GKRW 120
           F++     P+VVL+G  AV+EAL+ HGE+ + R   P+ + +  G    G+  +  G  W
Sbjct: 69  FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAW 128

Query: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
           +E RRF + TLRN G+GK+S+E  V EEA CL       +  P  P  +L  A  NVI S
Sbjct: 129 REQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIAS 188

Query: 181 VIFHDRFDYKDQRFLNLMEKFNENLR 206
           +    RF+Y D RFL L++   E L+
Sbjct: 189 LTCGRRFEYDDPRFLRLLDLAQEGLK 214


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  199 bits (505), Expect = 5e-51
 Identities = 140/446 (31%), Positives = 215/446 (48%), Gaps = 75/446 (16%)

Query: 30  PSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALID 89
           P GP   P+IGN   +  +    S    ++ YG VF +  G  PIVVL+G  A+ +AL+ 
Sbjct: 51  PPGPFAWPLIGNAAAVG-QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQ 109

Query: 90  HGEEFSGRGSFPVAEKVNKGLGILFSN-GKRWKEIRRFCLMTLRNF----GMGKRSIEDR 144
            G  F+ R +F     V+ G  + F +  + WK  RR     +RNF       ++ +E  
Sbjct: 110 QGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGH 169

Query: 145 VQEEARCLVEELRKTNASPC--DPTFILGCAPCNVICSVIF-----HD------------ 185
           V  EAR LV  L + +A     DP  +   A  NV+ +V F     HD            
Sbjct: 170 VLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNE 229

Query: 186 ------------------------------RFDYKDQRFLN-LMEKFN---ENLRILSSP 211
                                          F+  ++ F N +++KF    E+LR  ++P
Sbjct: 230 EFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAP 289

Query: 212 WIQ--------------EKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKY 257
                            + H   +   +E++ AT+TD+FGA  +T ST L++ LLL  +Y
Sbjct: 290 RDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRY 349

Query: 258 PEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKF 317
           P+V  +VQ E++ VVGR+R PCM D+ ++PY  A ++E  R+   +P  +PHA T +   
Sbjct: 350 PDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSV 409

Query: 318 KNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKK--SDYFMPFSAGKRM 375
             Y IPK T +  +  SV H+  ++PNPE FDP  FLDK G   K  +   M FS GKR 
Sbjct: 410 LGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRR 469

Query: 376 CMGEGLARMELFLFLTTILQNFNLKS 401
           C+GE L++M+LFLF++ +    + ++
Sbjct: 470 CIGEELSKMQLFLFISILAHQCDFRA 495


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  185 bits (469), Expect = 8e-47
 Identities = 135/484 (27%), Positives = 218/484 (45%), Gaps = 81/484 (16%)

Query: 8   VLCLSCLFLLSLWRQSSGRGRLPSG------PTPLPIIGNILQLDVKDMSKSLTNFSKVY 61
           +L  S +F L  W     R R+P G      P   P++G++L L  K+   +L+  S+ Y
Sbjct: 14  LLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRY 72

Query: 62  GPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFS--NGKR 119
           G V  +  G  P++VL   + +++AL+  G++F GR     +  +  G  + FS  +G  
Sbjct: 73  GDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPV 132

Query: 120 WKEIRRFCLMTLRNFGMGKRS-------IEDRVQEEARCLVEELRKTNASP--CDPTFIL 170
           W   RR     L  F +           +E+ V +EA+ L+  L++  A P   DP   +
Sbjct: 133 WAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQV 192

Query: 171 GCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNEN---------------LRILSSPWIQE 215
             +  NVI ++ F   F       L+L++  +E                LR L +P +Q 
Sbjct: 193 VVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQR 252

Query: 216 ------------------------------------KHNQQSE------FTVESLIATVT 233
                                               KH+++           E ++  V 
Sbjct: 253 FKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVN 312

Query: 234 DMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVV 293
           D+FGAG +T +T + + L+ L+  PE+  K+Q+E++ V+GR R P + DR  +PY +A +
Sbjct: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372

Query: 294 HEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHF 353
            E  R+   LP  +PH+ T D     + IPK   +  +   V H+ + + +P  F P  F
Sbjct: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432

Query: 354 LDKSG---NFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDP-KDID 409
           L   G   N   S+  M F  GKR C+GE LA+ E+FLFL  +LQ   L+  V P   +D
Sbjct: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPPGVKVD 490

Query: 410 ITPI 413
           +TPI
Sbjct: 491 LTPI 494


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  174 bits (440), Expect = 2e-43
 Identities = 131/465 (28%), Positives = 215/465 (46%), Gaps = 72/465 (15%)

Query: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKD-MSKSLTNFSKVYGP 63
           VAL+L L+  +L    R+  G  + P     LP++G++  L     M  +     K YGP
Sbjct: 5   VALLL-LTLAYLFWPKRRCPG-AKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGP 62

Query: 64  VFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGR---GSFPVAEKVNKGLGILFSNGKRW 120
           +++V  G K  V++  ++  KE LI  G++FSGR    +  +A    KG+    S G  W
Sbjct: 63  IYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADS-GAHW 121

Query: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
           +  RR  + T   F  G + +E  + +E   L + L   N    D +F +  A  NVI  
Sbjct: 122 QLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISL 181

Query: 181 VIFHDRF----------------------------------------------------D 188
           + F+  +                                                    D
Sbjct: 182 ICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRND 241

Query: 189 YKDQRFLNLMEKF-NENLRILSSPWIQEKHN---------QQSEFTVES-LIATVTDMFG 237
             ++   N  EKF ++++  +    +Q K N         Q SE   ++ ++ T+ D+FG
Sbjct: 242 LLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFG 301

Query: 238 AGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQ 297
           AG ETT++ +++ L  LL  P+V  K+ EEI+  VG +R+P + DR+ +   +A + E+ 
Sbjct: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361

Query: 298 RYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKS 357
           R   + P  +PH    D     + + KGT +I +L ++ HN+KE+  P+ F P  FL+ +
Sbjct: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421

Query: 358 GN--FKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK 400
           G      S  ++PF AG R C+GE LAR ELFL +  +LQ F+L+
Sbjct: 422 GTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  126 bits (317), Expect = 3e-29
 Identities = 111/434 (25%), Positives = 187/434 (43%), Gaps = 84/434 (19%)

Query: 37  PIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSG 96
           P+    L L   D+   L   ++ +GP++ ++ GL+ +VVL+    ++EA++    +F+G
Sbjct: 32  PLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAG 91

Query: 97  RGSFPVAEKV------NKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKR-SIEDRVQEEA 149
           R   P+  K+      +  LG      K  K++ R  L+      +G R S+E  V++  
Sbjct: 92  RPE-PLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLT 144

Query: 150 RCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNEN----- 204
           +   E +R    +P           C++IC + F D+   KD   +    K  +      
Sbjct: 145 QEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKI--KDDNLMPAYYKCIQEVLKTW 202

Query: 205 -------------LRILSSPWIQ------EKHNQQSEFTV----ESLIA----------- 230
                        LR   +P ++      EK +   E  +    ESL+A           
Sbjct: 203 SHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYML 262

Query: 231 ----------------------TVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEI 268
                                    D+   GTETT+ TL + ++ LL +PE+  ++QEE+
Sbjct: 263 QGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEEL 322

Query: 269 ECVVGRNRSPCM---QDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKG 325
           +  +G   S      +DR+ +P  +A + E+ R   ++P  LPH  T       Y IP+G
Sbjct: 323 DHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEG 382

Query: 326 TTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARME 385
           T II +L     ++  +  P  F P  FL+   N +     + F  G R+C+GE LAR+E
Sbjct: 383 TVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRA----LAFGCGARVCLGEPLARLE 438

Query: 386 LFLFLTTILQNFNL 399
           LF+ LT +LQ F L
Sbjct: 439 LFVVLTRLLQAFTL 452


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  107 bits (268), Expect = 2e-23
 Identities = 66/198 (33%), Positives = 104/198 (52%), Gaps = 10/198 (5%)

Query: 205 LRILSSPWIQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKV 264
           L+ ++ P ++E   Q  E  V        D+   GTETT+ TL + ++ LL +PE+  ++
Sbjct: 232 LQGVAQPSMEEGSGQLLEGHVHM---AAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRL 288

Query: 265 QEEIECVVGRNRSPCM---QDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYL 321
           QEE++  +G   S      +DR+ +P  +A + E+ R   ++P  LPH  T       Y 
Sbjct: 289 QEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYD 348

Query: 322 IPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGL 381
           IP+GT II +L     ++  +  P  F P  FL+   N +     + F  G R+C+GE L
Sbjct: 349 IPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRA----LAFGCGARVCLGEPL 404

Query: 382 ARMELFLFLTTILQNFNL 399
           AR+ELF+ LT +LQ F L
Sbjct: 405 ARLELFVVLTRLLQAFTL 422


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  100 bits (248), Expect = 3e-21
 Identities = 109/434 (25%), Positives = 167/434 (38%), Gaps = 72/434 (16%)

Query: 32  GPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHG 91
           GPTPLP +GNIL    K          K YG V+  Y G +P++ +   + +K  L+   
Sbjct: 40  GPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKEC 98

Query: 92  EE-FSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGK-RSIEDRVQEEA 149
              F+ R  F     +   + I  +  + WK +R     T   F  GK + +   + +  
Sbjct: 99  YSVFTNRRPFGPVGFMKSAISI--AEDEEWKRLRSLLSPT---FTSGKLKEMVPIIAQYG 153

Query: 150 RCLVEELRKT--NASPCDPTFILGCAPCNVICSVIFHD--------------------RF 187
             LV  LR+      P     + G    +VI S  F                      RF
Sbjct: 154 DVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRF 213

Query: 188 DYKDQRFLNL---------MEKFN------------------------ENLRILSSPWIQ 214
           D+ D  FL++         +E  N                        E+ +     ++Q
Sbjct: 214 DFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQ 273

Query: 215 EKHNQQSEFTVES--------LIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQE 266
              + Q+    ES        L+A       AG ETTS+ L + +  L  +P+V  K+QE
Sbjct: 274 LMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQE 333

Query: 267 EIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGT 326
           EI+ V+     P       M Y D VV+E  R   +    L      DV+     IPKG 
Sbjct: 334 EIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGV 392

Query: 327 TIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMEL 386
            ++    ++  + K +  PE F P  F  K+ +      + PF +G R C+G   A M +
Sbjct: 393 VVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNM 452

Query: 387 FLFLTTILQNFNLK 400
            L L  +LQNF+ K
Sbjct: 453 KLALIRVLQNFSFK 466


>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
           [Homo sapiens]
          Length = 372

 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 61/180 (33%), Positives = 94/180 (52%), Gaps = 4/180 (2%)

Query: 224 TVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDR 283
           T++ + A VT+M  AG +TTS TL + + LL ++PEV   V  EI   +G    P   D 
Sbjct: 166 TLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADV 225

Query: 284 SHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFP 343
             +P   A++ E  R   +LP N       D+    YLIPKGT +     +  + D+ FP
Sbjct: 226 PKVPLVRALLKETLRLFPVLPGN-GRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFP 284

Query: 344 NPEMFDPGHFLDKSGNFKKSDYF--MPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKS 401
             + F P  +L K G+  + D F  +PF  G R C+G  +A +E+ L +  +LQ+F +K+
Sbjct: 285 RAKEFRPERWLRK-GDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKT 343


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 57/185 (30%), Positives = 90/185 (48%), Gaps = 4/185 (2%)

Query: 220 QSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVV--GRNRS 277
           + E   +S++  VT++  AG +T S TL + L  L ++PEV   +  EI   +  G +  
Sbjct: 299 REELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAY 358

Query: 278 PCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLH 337
           P     S +P   AVV E+ R   ++P N       D+   +Y+IPK T +     +   
Sbjct: 359 PSATVLSQLPLLKAVVKEVLRLYPVVPGN-SRVPDKDIHVGDYIIPKNTLVTLCHYATSR 417

Query: 338 NDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNF 397
           +  +FP P  F P  +L + G        +PF  GKR CMG  LA +EL + L  IL +F
Sbjct: 418 DPAQFPEPNSFRPARWLGE-GPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHF 476

Query: 398 NLKSQ 402
            ++ +
Sbjct: 477 EVQPE 481


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 103/437 (23%), Positives = 170/437 (38%), Gaps = 79/437 (18%)

Query: 32  GPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALI-DH 90
           GPTPLP++GN+L    + + K  T   K YG ++  Y G  P++ +   + ++  L+ + 
Sbjct: 40  GPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKEC 98

Query: 91  GEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGK-RSIEDRVQEEA 149
              F+ R S      +   + +  +  + WK IR     T   F  GK + +   + +  
Sbjct: 99  YSVFTNRRSLGPVGFMKSAISL--AEDEEWKRIRSLLSPT---FTSGKLKEMFPIIAQYG 153

Query: 150 RCLVEELRK--TNASPCDPTFILGCAPCNVICSVIF--------------------HDRF 187
             LV  LR+      P     I G    +VI    F                      +F
Sbjct: 154 DVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKF 213

Query: 188 DYKDQRFLNLM---------EKFN-------------ENLRILSSPWIQEKHNQQSEF-- 223
            + D  FL+++         E  N             +++  +    + +K   + +F  
Sbjct: 214 GFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQ 273

Query: 224 ------------------TVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQ 265
                              +E    ++  +F     T+S  L + L  L  +P+V  K+Q
Sbjct: 274 LMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSS-VLSFTLYELATHPDVQQKLQ 332

Query: 266 EEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTC--DVKFKNYLIP 323
           +EI+ V+     P       M Y D VV+E  R   L P  +    TC  DV+     IP
Sbjct: 333 KEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR---LFPVAIRLERTCKKDVEINGVFIP 389

Query: 324 KGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLAR 383
           KG+ ++    ++ H+ K +  PE F P  F  K  +     Y  PF  G R C+G   A 
Sbjct: 390 KGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY-TPFGTGPRNCIGMRFAL 448

Query: 384 MELFLFLTTILQNFNLK 400
           M + L L  +LQNF+ K
Sbjct: 449 MNMKLALIRVLQNFSFK 465


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score = 89.0 bits (219), Expect = 8e-18
 Identities = 96/432 (22%), Positives = 175/432 (40%), Gaps = 66/432 (15%)

Query: 32  GPTPLPIIGNILQL----DVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEAL 87
           GPT  P++G++LQ+     +K    +L  + K YG +F +  G    V L G   + EAL
Sbjct: 60  GPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL-GSPCLLEAL 118

Query: 88  IDHGEEFSGRGSF----PVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIED 143
                 +  R          +   +G G+L   G+ W+ +R      L   G   + +++
Sbjct: 119 YRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMK-LDN 177

Query: 144 RVQE---EARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEK 200
           ++ E   +    ++EL        D    L       IC V++  RF    +   +    
Sbjct: 178 KINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVN 237

Query: 201 FNENLRILSSPWIQ---------------------------------------EKHNQQ- 220
           F   ++ + S + +                                       EK++QQ 
Sbjct: 238 FIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQP 297

Query: 221 -----------SEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIE 269
                      +  + + L A VT++  A  ETT+ +L + L  L + P+V  K+ +EI+
Sbjct: 298 SADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQ 357

Query: 270 CVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTII 329
            V+  N+ P  +D  +MPY  A + E  R    +P          V    Y +PKGT ++
Sbjct: 358 SVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATV-LGEYALPKGTVLM 416

Query: 330 TSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLF 389
            +   +  ++  F +   F P  +L +        + +PF  GKRMC+G  LA ++L L 
Sbjct: 417 LNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAH-LPFGVGKRMCIGRRLAELQLHLA 475

Query: 390 LTTILQNFNLKS 401
           L  I++ +++++
Sbjct: 476 LCWIVRKYDIQA 487


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.140    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,910,510
Number of Sequences: 37866
Number of extensions: 758925
Number of successful extensions: 1760
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1555
Number of HSP's gapped (non-prelim): 130
length of query: 431
length of database: 18,247,518
effective HSP length: 105
effective length of query: 326
effective length of database: 14,271,588
effective search space: 4652537688
effective search space used: 4652537688
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.