Search of human proteins with 193083131

Search of human proteins with 193083131

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|193083131 MAP/microtubule affinity-regulating kinase 3
isoform e [Homo sapiens]
         (659 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|193083131 MAP/microtubule affinity-regulating kinase 3 isofor...  1304   0.0  
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor...   942   0.0  
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform...   927   0.0  
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor...   927   0.0  
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor...   889   0.0  
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ...   576   e-164
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor...   492   e-139
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor...   484   e-137
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor...   483   e-136
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor...   469   e-132
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform...   468   e-132
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s...   376   e-104
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]        177   3e-44
gi|38569460 SNF1-like kinase 2 [Homo sapiens]                         169   1e-41
gi|116256471 SNF1-like kinase [Homo sapiens]                          165   1e-40
gi|156105707 SNF related kinase [Homo sapiens]                        145   9e-35
gi|156105705 SNF related kinase [Homo sapiens]                        145   9e-35
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]               145   9e-35
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]              142   7e-34
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun...   139   1e-32
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub...   137   4e-32
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]       134   3e-31
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]               130   5e-30
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub...   127   4e-29
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]    127   4e-29
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]           124   4e-28
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa...   113   6e-25
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha...   105   1e-22
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha...   105   1e-22
gi|212549756 calcium/calmodulin-dependent protein kinase II delt...   103   5e-22

>gi|193083131 MAP/microtubule affinity-regulating kinase 3 isoform e
           [Homo sapiens]
          Length = 659

 Score = 1304 bits (3375), Expect = 0.0
 Identities = 659/659 (100%), Positives = 659/659 (100%)

Query: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK
Sbjct: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180

Query: 181 ELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPF 240
           ELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPF
Sbjct: 181 ELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPF 240

Query: 241 VEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSS 300
           VEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSS
Sbjct: 241 VEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSS 300

Query: 301 SNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTS 360
           SNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTS
Sbjct: 301 SNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTS 360

Query: 361 TADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTAS 420
           TADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTAS
Sbjct: 361 TADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTAS 420

Query: 421 GGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGT 480
           GGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGT
Sbjct: 421 GGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGT 480

Query: 481 ASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSF 540
           ASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSF
Sbjct: 481 ASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSF 540

Query: 541 RFIKSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRE 600
           RFIKSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRE
Sbjct: 541 RFIKSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRE 600

Query: 601 RFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 659
           RFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
Sbjct: 601 RFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 659


>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
           [Homo sapiens]
          Length = 753

 Score =  942 bits (2436), Expect = 0.0
 Identities = 481/498 (96%), Positives = 483/498 (96%), Gaps = 15/498 (3%)

Query: 177 RDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 236
           ++LKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE
Sbjct: 256 QNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 315

Query: 237 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 296
           LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD
Sbjct: 316 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 375

Query: 297 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR 356
           SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR
Sbjct: 376 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR 435

Query: 357 SQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSS 416
           SQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSS
Sbjct: 436 SQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSS 495

Query: 417 NTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRF 476
           NTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRF
Sbjct: 496 NTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRF 555

Query: 477 PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRR 536
           PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRR
Sbjct: 556 PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRR 615

Query: 537 NMSFRFIK---------------SRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDM 581
           NMSFRFIK               SRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDM
Sbjct: 616 NMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDM 675

Query: 582 MREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISG 641
           MREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISG
Sbjct: 676 MREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISG 735

Query: 642 TSIAFKNIASKIANELKL 659
           TSIAFKNIASKIANELKL
Sbjct: 736 TSIAFKNIASKIANELKL 753



 Score =  360 bits (924), Expect = 2e-99
 Identities = 180/180 (100%), Positives = 180/180 (100%)

Query: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK
Sbjct: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180


>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
           [Homo sapiens]
          Length = 729

 Score =  927 bits (2396), Expect = 0.0
 Identities = 472/483 (97%), Positives = 474/483 (98%), Gaps = 9/483 (1%)

Query: 177 RDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 236
           ++LKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE
Sbjct: 256 QNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 315

Query: 237 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 296
           LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD
Sbjct: 316 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 375

Query: 297 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR 356
           SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR
Sbjct: 376 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR 435

Query: 357 SQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSS 416
           SQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSS
Sbjct: 436 SQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSS 495

Query: 417 NTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRF 476
           NTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRF
Sbjct: 496 NTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRF 555

Query: 477 PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRR 536
           PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTR 
Sbjct: 556 PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTR- 614

Query: 537 NMSFRFIKSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDY 596
                   SRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDY
Sbjct: 615 --------SRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDY 666

Query: 597 EQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANE 656
           EQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANE
Sbjct: 667 EQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANE 726

Query: 657 LKL 659
           LKL
Sbjct: 727 LKL 729



 Score =  360 bits (924), Expect = 2e-99
 Identities = 180/180 (100%), Positives = 180/180 (100%)

Query: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK
Sbjct: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180


>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
           [Homo sapiens]
          Length = 744

 Score =  927 bits (2395), Expect = 0.0
 Identities = 474/489 (96%), Positives = 478/489 (97%), Gaps = 6/489 (1%)

Query: 177 RDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 236
           ++LKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE
Sbjct: 256 QNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 315

Query: 237 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 296
           LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD
Sbjct: 316 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 375

Query: 297 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR 356
           SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR
Sbjct: 376 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR 435

Query: 357 SQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSS 416
           SQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSS
Sbjct: 436 SQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSS 495

Query: 417 NTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRF 476
           NTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRF
Sbjct: 496 NTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRF 555

Query: 477 PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRR 536
           PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRR
Sbjct: 556 PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRR 615

Query: 537 -----NMSFRFI-KSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLD 590
                  + R+   SRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLD
Sbjct: 616 LPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLD 675

Query: 591 ANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIA 650
           ANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIA
Sbjct: 676 ANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIA 735

Query: 651 SKIANELKL 659
           SKIANELKL
Sbjct: 736 SKIANELKL 744



 Score =  360 bits (924), Expect = 2e-99
 Identities = 180/180 (100%), Positives = 180/180 (100%)

Query: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK
Sbjct: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180


>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
           [Homo sapiens]
          Length = 713

 Score =  889 bits (2298), Expect = 0.0
 Identities = 456/483 (94%), Positives = 458/483 (94%), Gaps = 25/483 (5%)

Query: 177 RDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 236
           ++LKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE
Sbjct: 256 QNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 315

Query: 237 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 296
           LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSE     
Sbjct: 316 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSE----- 370

Query: 297 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR 356
                      VRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR
Sbjct: 371 -----------VRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR 419

Query: 357 SQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSS 416
           SQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSS
Sbjct: 420 SQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSS 479

Query: 417 NTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRF 476
           NTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRF
Sbjct: 480 NTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRF 539

Query: 477 PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRR 536
           PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTR 
Sbjct: 540 PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTR- 598

Query: 537 NMSFRFIKSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDY 596
                   SRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDY
Sbjct: 599 --------SRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDY 650

Query: 597 EQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANE 656
           EQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANE
Sbjct: 651 EQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANE 710

Query: 657 LKL 659
           LKL
Sbjct: 711 LKL 713



 Score =  360 bits (924), Expect = 2e-99
 Identities = 180/180 (100%), Positives = 180/180 (100%)

Query: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK
Sbjct: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180


>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
           sapiens]
          Length = 795

 Score =  576 bits (1485), Expect = e-164
 Identities = 329/552 (59%), Positives = 384/552 (69%), Gaps = 85/552 (15%)

Query: 177 RDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 236
           ++LKELRERVLRGKYRIPFYMSTDCENLLK+ LVLNPIKRG+LEQIMKDRW+N GHEE+E
Sbjct: 260 QNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEE 319

Query: 237 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 296
           LKP+ EP+ D +D KRIDIMV MG++++EI ++L   KYDE+ ATY+LLGRK  E +  +
Sbjct: 320 LKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMATYILLGRKPPEFEGGE 379

Query: 297 SSSSSNLSLAKVRPSSDLNNSTGQSPHH-KVQRSVFSSQKQRRYSDHAGPAIPSVVAYPK 355
           S SS NL   + RPSSDLNNST QSP H KVQRS+ ++QKQRR+SDHAGP+IP  V+Y K
Sbjct: 380 SLSSGNL-CQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGPSIPPAVSYTK 438

Query: 356 RSQTSTADSDLKE--DGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTV 413
           R Q ++ +S+ KE  D   +RK   + VG K    ASP++G          PERKKSST+
Sbjct: 439 RPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVG----------PERKKSSTI 488

Query: 414 PSSNTASGG-MTRRNTYVCSERTTADRHSVIQNGKENS---------------------- 450
           PS+N  SGG M RRNTYVC ERTT DR+  +QNGK++S                      
Sbjct: 489 PSNNVYSGGSMARRNTYVC-ERTT-DRYVALQNGKDSSLTEMSVSSISSAGSSVASAVPS 546

Query: 451 ---------------------TIPD----------QRTPVA--STHSISSAATPDRIRFP 477
                                TI D          QR P A  S HSIS+ ATPDR RFP
Sbjct: 547 ARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSIST-ATPDRTRFP 605

Query: 478 RGTASRSTFHG-QPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRR 536
           RG++SRSTFHG Q RERR+  YNGPPASP  SHE    +  R   ST + SK+TSK  RR
Sbjct: 606 RGSSSRSTFHGEQLRERRSVAYNGPPASP--SHETGAFAHARRGTSTGIISKITSKFVRR 663

Query: 537 N-----MSFRFIKSRNVSAE----QKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRK 587
           +      S R   SR+ S E     K+E K++KPRSLRFTWSMKTTSSMDP DMMREIRK
Sbjct: 664 DPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPNDMMREIRK 723

Query: 588 VLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFK 647
           VLDANNCDYEQ+ERFLLFCVHGD   ++LVQWEMEVCKLPRLSLNGVRFKRISGTSIAFK
Sbjct: 724 VLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFK 783

Query: 648 NIASKIANELKL 659
           NIASKIANELKL
Sbjct: 784 NIASKIANELKL 795



 Score =  305 bits (781), Expect = 9e-83
 Identities = 157/185 (84%), Positives = 165/185 (89%), Gaps = 6/185 (3%)

Query: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGAR-----CRNSIASCADEQPHIGN 55
           MS RTPLPTVNERDTENHTS  DG  E   + ++S +R     CRNSI S  DEQPHIGN
Sbjct: 1   MSARTPLPTVNERDTENHTSV-DGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGN 59

Query: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115
           YRL KTIGKGNFAKVKLARH+LTGREVA+KIIDKTQLNPTSLQKLFREVRIMKILNHPNI
Sbjct: 60  YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 119

Query: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 175
           VKLFEVIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IV
Sbjct: 120 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV 179

Query: 176 HRDLK 180
           HRDLK
Sbjct: 180 HRDLK 184


>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
           [Homo sapiens]
          Length = 719

 Score =  492 bits (1267), Expect = e-139
 Identities = 285/498 (57%), Positives = 353/498 (70%), Gaps = 46/498 (9%)

Query: 177 RDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 236
           ++LKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQIMKDRW+N GHE+DE
Sbjct: 253 QNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDE 312

Query: 237 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 296
           LKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ ATYLLLG KSSEL+   
Sbjct: 313 LKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDT 372

Query: 297 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDH-AGPAIPSVVAYPK 355
            +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD  AGPAIP+  +Y K
Sbjct: 373 IT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSK 425

Query: 356 RSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVP 414
           ++Q++ A++   +ED  S RK+S +A       PASP+ G           ERKK++  P
Sbjct: 426 KTQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPG----------LERKKTTPTP 470

Query: 415 SSNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPDQRTPVA--STHSISSA-AT 470
           S+N+     T R+      ER +  + S IQNGK+ ST P QR PVA  S H+ISS+   
Sbjct: 471 STNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKD-STAP-QRVPVASPSAHNISSSGGA 527

Query: 471 PDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLF 526
           PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H     SQ R   S ++F
Sbjct: 528 PDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-----SQGRRGASGSIF 581

Query: 527 SKLTSKLTRRNMSFRFIKSRNV-----SAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDM 581
           SK TSK  RRN+SFRF +  +V     + ++K+E +EAKPRSLRFTWSMKTTSSM+P +M
Sbjct: 582 SKFTSKFVRRNLSFRFARRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEM 641

Query: 582 MREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISG 641
           MREIRKVLDAN+C  E  E+++L C+HG    E+ VQWEMEVCKLPRLSLNGVRFKRISG
Sbjct: 642 MREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISG 701

Query: 642 TSIAFKNIASKIANELKL 659
           TS+AFKNIASKIANELKL
Sbjct: 702 TSMAFKNIASKIANELKL 719



 Score =  281 bits (719), Expect = 1e-75
 Identities = 148/180 (82%), Positives = 157/180 (87%), Gaps = 6/180 (3%)

Query: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177


>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
           [Homo sapiens]
          Length = 724

 Score =  484 bits (1247), Expect = e-137
 Identities = 282/503 (56%), Positives = 349/503 (69%), Gaps = 51/503 (10%)

Query: 177 RDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 236
           ++LKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQIMKDRW+N GHE+DE
Sbjct: 253 QNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDE 312

Query: 237 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 296
           LKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ ATYLLLG KSSEL+   
Sbjct: 313 LKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDT 372

Query: 297 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR 356
            +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD AGPAIP+  +Y K+
Sbjct: 373 IT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSNSYSKK 425

Query: 357 SQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPS 415
           +Q++ A++   +ED  S RK+S +A       PASP+ G           ERKK++  PS
Sbjct: 426 TQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPG----------LERKKTTPTPS 470

Query: 416 SNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPDQRTPVA--STHSISSA-ATP 471
           +N+     T R+      ER +  + S IQNGK+ ST P QR PVA  S H+ISS+   P
Sbjct: 471 TNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKD-STAP-QRVPVASPSAHNISSSGGAP 527

Query: 472 DRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFS 527
           DR  FPRG +SRSTFH     Q R+++   Y   PASPS  H     SQ R   S ++FS
Sbjct: 528 DRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-----SQGRRGASGSIFS 581

Query: 528 KLTSKLTRRNMSFRFIKSR-----------NVSAEQKDENKEAKPRSLRFTWSMKTTSSM 576
           K TSK  RRN++    K R             + ++K+E +EAKPRSLRFTWSMKTTSSM
Sbjct: 582 KFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSM 641

Query: 577 DPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRF 636
           +P +MMREIRKVLDAN+C  E  E+++L C+HG    E+ VQWEMEVCKLPRLSLNGVRF
Sbjct: 642 EPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRF 701

Query: 637 KRISGTSIAFKNIASKIANELKL 659
           KRISGTS+AFKNIASKIANELKL
Sbjct: 702 KRISGTSMAFKNIASKIANELKL 724



 Score =  281 bits (719), Expect = 1e-75
 Identities = 148/180 (82%), Positives = 157/180 (87%), Gaps = 6/180 (3%)

Query: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177


>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
           [Homo sapiens]
          Length = 709

 Score =  483 bits (1242), Expect = e-136
 Identities = 279/492 (56%), Positives = 345/492 (70%), Gaps = 44/492 (8%)

Query: 177 RDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 236
           ++LKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQIMKDRW+N GHE+DE
Sbjct: 253 QNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDE 312

Query: 237 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 296
           LKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ ATYLLLG KSSEL+   
Sbjct: 313 LKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDT 372

Query: 297 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR 356
            +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD AGPAIP+  +Y K+
Sbjct: 373 IT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSNSYSKK 425

Query: 357 SQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPS 415
           +Q++ A++   +ED  S RK+S +A       PASP+ G           ERKK++  PS
Sbjct: 426 TQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPG----------LERKKTTPTPS 470

Query: 416 SNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPDQRTPVA--STHSISSA-ATP 471
           +N+     T R+      ER +  + S IQNGK+ ST P QR PVA  S H+ISS+   P
Sbjct: 471 TNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKD-STAP-QRVPVASPSAHNISSSGGAP 527

Query: 472 DRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFS 527
           DR  FPRG +SRSTFH     Q R+++   Y   PASPS  H     SQ R   S ++FS
Sbjct: 528 DRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-----SQGRRGASGSIFS 581

Query: 528 KLTSKLTRRNMSFRFIKSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRK 587
           K TSK  RR      +     + ++K+E +EAKPRSLRFTWSMKTTSSM+P +MMREIRK
Sbjct: 582 KFTSKFVRR----PHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRK 637

Query: 588 VLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFK 647
           VLDAN+C  E  E+++L C+HG    E+ VQWEMEVCKLPRLSLNGVRFKRISGTS+AFK
Sbjct: 638 VLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFK 697

Query: 648 NIASKIANELKL 659
           NIASKIANELKL
Sbjct: 698 NIASKIANELKL 709



 Score =  281 bits (719), Expect = 1e-75
 Identities = 148/180 (82%), Positives = 157/180 (87%), Gaps = 6/180 (3%)

Query: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177


>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
           [Homo sapiens]
          Length = 788

 Score =  469 bits (1207), Expect = e-132
 Identities = 285/566 (50%), Positives = 355/566 (62%), Gaps = 113/566 (19%)

Query: 177 RDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 236
           ++LKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQIMKDRW+N GHE+DE
Sbjct: 253 QNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDE 312

Query: 237 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 296
           LKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ ATYLLLG KSSEL+   
Sbjct: 313 LKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDT 372

Query: 297 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHA-GPAIPSVVAYPK 355
            +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD A GPAIP+  +Y K
Sbjct: 373 IT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSK 425

Query: 356 RSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVP 414
           ++Q++ A++   +ED  S RK+S +A       PASP+ G           ERKK++  P
Sbjct: 426 KTQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPGL----------ERKKTTPTP 470

Query: 415 SSNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPD------------------- 454
           S+N+     T R+      ER +  + S IQNGK++ T+P                    
Sbjct: 471 STNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKDSLTMPGSRASTASASAAVSAARPRQ 529

Query: 455 ---------------------------------QRTPVAS--THSISSAA-TPDRIRFPR 478
                                            QR PVAS   H+ISS+   PDR  FPR
Sbjct: 530 HQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPR 589

Query: 479 GTASRSTFHG----QPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLT 534
           G +SRSTFH     Q R+++   Y   PASPS  H     SQ R   S ++FSK TSK  
Sbjct: 590 GVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-----SQGRRGASGSIFSKFTSKFV 643

Query: 535 RRNMSFRFIKSRNVSA---------------------EQKDENKEAKPRSLRFTWSMKTT 573
           RRN+SFRF + RN++                      ++K+E +EAKPRSLRFTWSMKTT
Sbjct: 644 RRNLSFRFAR-RNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTT 702

Query: 574 SSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNG 633
           SSM+P +MMREIRKVLDAN+C  E  E+++L C+HG    E+ VQWEMEVCKLPRLSLNG
Sbjct: 703 SSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNG 762

Query: 634 VRFKRISGTSIAFKNIASKIANELKL 659
           VRFKRISGTS+AFKNIASKIANELKL
Sbjct: 763 VRFKRISGTSMAFKNIASKIANELKL 788



 Score =  281 bits (719), Expect = 1e-75
 Identities = 148/180 (82%), Positives = 157/180 (87%), Gaps = 6/180 (3%)

Query: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177


>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
           [Homo sapiens]
          Length = 745

 Score =  468 bits (1204), Expect = e-132
 Identities = 281/555 (50%), Positives = 350/555 (63%), Gaps = 101/555 (18%)

Query: 177 RDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 236
           ++LKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQIMKDRW+N GHE+DE
Sbjct: 220 QNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDE 279

Query: 237 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 296
           LKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ ATYLLLG KSSEL+   
Sbjct: 280 LKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDT 339

Query: 297 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR 356
            +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD AGPAIP+  +Y K+
Sbjct: 340 IT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSNSYSKK 392

Query: 357 SQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPS 415
           +Q++ A++   +ED  S RK+S +A       PASP+ G           ERKK++  PS
Sbjct: 393 TQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPGL----------ERKKTTPTPS 437

Query: 416 SNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPD-------------------- 454
           +N+     T R+      ER +  + S IQNGK++ T+P                     
Sbjct: 438 TNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKDSLTMPGSRASTASASAAVSAARPRQH 496

Query: 455 --------------------------------QRTPVAS--THSISSAA-TPDRIRFPRG 479
                                           QR PVAS   H+ISS+   PDR  FPRG
Sbjct: 497 QKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRG 556

Query: 480 TASRSTFHG----QPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTR 535
            +SRSTFH     Q R+++   Y   PASPS  H     SQ R   S ++FSK TSK  R
Sbjct: 557 VSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-----SQGRRGASGSIFSKFTSKFVR 610

Query: 536 RNMSFRFIKSR-----------NVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMRE 584
           RN++    K R             + ++K+E +EAKPRSLRFTWSMKTTSSM+P +MMRE
Sbjct: 611 RNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMRE 670

Query: 585 IRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSI 644
           IRKVLDAN+C  E  E+++L C+HG    E+ VQWEMEVCKLPRLSLNGVRFKRISGTS+
Sbjct: 671 IRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSM 730

Query: 645 AFKNIASKIANELKL 659
           AFKNIASKIANELKL
Sbjct: 731 AFKNIASKIANELKL 745



 Score =  259 bits (661), Expect = 7e-69
 Identities = 131/143 (91%), Positives = 138/143 (96%), Gaps = 1/143 (0%)

Query: 38  RCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL 97
           R RNS A+ ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SL
Sbjct: 3   RGRNS-ATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL 61

Query: 98  QKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARS 157
           QKLFREVRIMK+LNHPNIVKLFEVIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+
Sbjct: 62  QKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA 121

Query: 158 KFRQIVSAVQYCHQKRIVHRDLK 180
           KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 122 KFRQIVSAVQYCHQKFIVHRDLK 144


>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
           sapiens]
          Length = 688

 Score =  376 bits (965), Expect = e-104
 Identities = 210/373 (56%), Positives = 263/373 (70%), Gaps = 20/373 (5%)

Query: 178 DLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDEL 237
           +LKELRERVLRGKYR+PFYMSTDCE++L+RFLVLNP KR TLEQIMKD+WIN G+E +EL
Sbjct: 260 NLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEEL 319

Query: 238 KPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDS 297
           KP+ EPE D  D KRI++MVGMGY++EEI+ESL+  KY+E+TATYLLLGRK+ E      
Sbjct: 320 KPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEE---GGD 376

Query: 298 SSSSNLSLAKVRPSSDLNNSTGQS---PHHKVQRSVFSS-QKQRRYSDHAGPAIPSVVAY 353
             +  L+LA+VR  SD  N T  S    H K QRS  S+  +QRR+SD  GP+      +
Sbjct: 377 RGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPS--PAPLH 434

Query: 354 PKRSQTSTADSDLKEDGISSRKSSGSAV--GGKGIAPASPMLGNASNPNKADIPERKKSS 411
           PKRS TST +++LKE+ +  RK+S S    G +G+ P+SPM+ +A NPNKA+IPER+K S
Sbjct: 435 PKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDS 494

Query: 412 TVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSA-AT 470
           T   +N     MTRRNTYVC+ER  A+R S++ NGKENS+    R P AS  S S A  +
Sbjct: 495 TSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSS-GTPRVPPASPSSHSLAPPS 553

Query: 471 PDRIRFPRGTASRSTFH-GQPRERRT------ATYNGPPASPSLSHEATPLSQTRSRGST 523
            +R R  RG+  RSTFH GQ R+RR          NGPPASP+L+HEA PL   R R +T
Sbjct: 554 GERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTT 613

Query: 524 NLFSKLTSKLTRR 536
           NLF+KLTSKLTRR
Sbjct: 614 NLFTKLTSKLTRR 626


>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
          Length = 1263

 Score =  177 bits (449), Expect = 3e-44
 Identities = 84/128 (65%), Positives = 110/128 (85%)

Query: 53  IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
           IG Y + +TIGKGNFA VK A H++T  +VAIKIIDKTQL+  +L+K+FREV+IMK+L H
Sbjct: 5   IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64

Query: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
           P+I++L++V+ETE+ +YL+ EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH +
Sbjct: 65  PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124

Query: 173 RIVHRDLK 180
            IVHRDLK
Sbjct: 125 NIVHRDLK 132



 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 43/115 (37%), Positives = 67/115 (58%), Gaps = 8/115 (6%)

Query: 179 LKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELK 238
           L+ LR RVL GK+RIPF+MST+CE+L++  LVL+P KR ++EQI K +W+  G  +    
Sbjct: 210 LQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFD 269

Query: 239 PFVEPELDISDQKRID--------IMVGMGYSQEEIQESLSKMKYDEITATYLLL 285
             +     + +++++D         M  MG  +E+  +SL    YD  +A Y LL
Sbjct: 270 RLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLL 324


>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
          Length = 926

 Score =  169 bits (427), Expect = 1e-41
 Identities = 79/128 (61%), Positives = 104/128 (81%)

Query: 53  IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
           +G Y +  T+GKGNFA VKL RH +T  EVAIKIIDK+QL+  +L+K++REV+IMK+L+H
Sbjct: 17  VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76

Query: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
           P+I+KL++V+ET+  LYL+ EYA  GE+FDYL  HGR+ E EAR KF QI+SAV YCH +
Sbjct: 77  PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136

Query: 173 RIVHRDLK 180
           +IVHRDLK
Sbjct: 137 KIVHRDLK 144



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 42/109 (38%), Positives = 65/109 (59%), Gaps = 5/109 (4%)

Query: 182 LRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRW--INAGHEEDELKP 239
           LR+RVL G++RIP++MS DCE+L++R LVL+P KR T+ QI + +W  I    +   L P
Sbjct: 225 LRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYP 284

Query: 240 FV---EPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLL 285
                EP +   +++ + +M  +G  Q++  ESL    Y+   A Y LL
Sbjct: 285 QEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLL 333


>gi|116256471 SNF1-like kinase [Homo sapiens]
          Length = 783

 Score =  165 bits (418), Expect = 1e-40
 Identities = 75/128 (58%), Positives = 106/128 (82%)

Query: 53  IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
           +G Y + +T+GKGNFA VKLARH +T  +VAIKIIDKT+L+ ++L+K++REV++MK+LNH
Sbjct: 24  VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83

Query: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
           P+I+KL++V+ET+  LY++ E+A  GE+FDYL ++G + E EAR KF QI+SAV+YCH  
Sbjct: 84  PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143

Query: 173 RIVHRDLK 180
            IVHRDLK
Sbjct: 144 HIVHRDLK 151



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 45/123 (36%), Positives = 67/123 (54%), Gaps = 12/123 (9%)

Query: 178 DLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDEL 237
           +L  LR+RVL G++RIPF+MS DCE+L++R LV++P +R T+ QI + RW+ A   E  L
Sbjct: 228 NLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRA---EPCL 284

Query: 238 KPFVEP---------ELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRK 288
                P          L   D++ + IM  +G  ++   ESL    Y+   A Y LL  +
Sbjct: 285 PGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLER 344

Query: 289 SSE 291
             E
Sbjct: 345 LKE 347


>gi|156105707 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  145 bits (367), Expect = 9e-35
 Identities = 69/128 (53%), Positives = 96/128 (75%), Gaps = 1/128 (0%)

Query: 54  GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
           G Y L KT+G+G+FA VKLARH+ TG +VA+K+IDKT+L+  +   LF+EVR MK++ HP
Sbjct: 14  GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73

Query: 114 NIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR-MKEKEARSKFRQIVSAVQYCHQK 172
           NIV+L+EVI+T+  LYLI+E   GG++FDY++ H   + E  A+  F QIV A+ YCH+ 
Sbjct: 74  NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133

Query: 173 RIVHRDLK 180
            +VHRDLK
Sbjct: 134 HVVHRDLK 141



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 41/154 (26%), Positives = 74/154 (48%), Gaps = 12/154 (7%)

Query: 169 CHQKRIVHRDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 228
           C Q      +  E    ++  KY +P ++S +C++L+ R L  +P +R +LE+I    W+
Sbjct: 210 CGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWL 269

Query: 229 NAGHEEDELK---PFVEPELDISDQKRIDI----MVGMGYSQEEIQESLSKMKYDEITAT 281
                    K   P V  + ++S+++   I    ++G    ++ I E+L   +Y+ ITAT
Sbjct: 270 QGVDPSPATKYNIPLVSYK-NLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITAT 328

Query: 282 YLLLG----RKSSELDASDSSSSSNLSLAKVRPS 311
           Y LL     R+  E +    S+S +   A+ R S
Sbjct: 329 YFLLAERILREKQEKEIQTRSASPSNIKAQFRQS 362


>gi|156105705 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  145 bits (367), Expect = 9e-35
 Identities = 69/128 (53%), Positives = 96/128 (75%), Gaps = 1/128 (0%)

Query: 54  GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
           G Y L KT+G+G+FA VKLARH+ TG +VA+K+IDKT+L+  +   LF+EVR MK++ HP
Sbjct: 14  GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73

Query: 114 NIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR-MKEKEARSKFRQIVSAVQYCHQK 172
           NIV+L+EVI+T+  LYLI+E   GG++FDY++ H   + E  A+  F QIV A+ YCH+ 
Sbjct: 74  NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133

Query: 173 RIVHRDLK 180
            +VHRDLK
Sbjct: 134 HVVHRDLK 141



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 41/154 (26%), Positives = 74/154 (48%), Gaps = 12/154 (7%)

Query: 169 CHQKRIVHRDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 228
           C Q      +  E    ++  KY +P ++S +C++L+ R L  +P +R +LE+I    W+
Sbjct: 210 CGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWL 269

Query: 229 NAGHEEDELK---PFVEPELDISDQKRIDI----MVGMGYSQEEIQESLSKMKYDEITAT 281
                    K   P V  + ++S+++   I    ++G    ++ I E+L   +Y+ ITAT
Sbjct: 270 QGVDPSPATKYNIPLVSYK-NLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITAT 328

Query: 282 YLLLG----RKSSELDASDSSSSSNLSLAKVRPS 311
           Y LL     R+  E +    S+S +   A+ R S
Sbjct: 329 YFLLAERILREKQEKEIQTRSASPSNIKAQFRQS 362


>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
          Length = 778

 Score =  145 bits (367), Expect = 9e-35
 Identities = 68/129 (52%), Positives = 97/129 (75%)

Query: 52  HIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILN 111
           ++G YRL KT+GKG    VKL  H +TG++VAIKI+++ +L+ + L K+ RE+ I+K++ 
Sbjct: 30  YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89

Query: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171
           HP+++KL +V E +K LYL++E+ SGGE+FDYLV  GR+  KEAR  FRQIVSA+ +CH 
Sbjct: 90  HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149

Query: 172 KRIVHRDLK 180
             I HRDLK
Sbjct: 150 YSICHRDLK 158



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 101/418 (24%), Positives = 164/418 (39%), Gaps = 70/418 (16%)

Query: 178 DLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAG-HEEDE 236
           +L++L E+V RG + +P ++  DC++LL+  + + P KR +LEQI K  W   G HE D 
Sbjct: 235 NLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPD- 293

Query: 237 LKPFVEP---------------ELDISDQKRIDIMVGMGYSQEEIQESL-SKMKYDEITA 280
             P +EP               ELD  D       +G    +E +   L S+ +  E   
Sbjct: 294 --PCLEPAPGRRVAMRSLPSNGELD-PDVLESMASLGCFRDRERLHRELRSEEENQEKMI 350

Query: 281 TYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYS 340
            YLLL RK       D           + P +D++      P  +V   + S   +RR  
Sbjct: 351 YYLLLDRKERYPSCEDQD---------LPPRNDVD-----PPRKRVDSPMLSRHGKRRPE 396

Query: 341 DHAGPAIPSVVAYPKRSQTSTADS-DLKEDGISSRKSSGSAVGGKG---IAPASPMLGNA 396
             +   +    A    S   T  + ++ +    SR  SG++ G       +P SP+   +
Sbjct: 397 RKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFS 456

Query: 397 SNPNKADIPE-----RKKSSTVPSSNTASGGM-------TRRNTYV----CSERTTADR- 439
             P   D          K+ T+PS     GG        + R+T +     S R++    
Sbjct: 457 PEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTP 516

Query: 440 -HSVIQNGKENST-IPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPR-ERRTA 496
            HS +   + + T  P    P +    +  AA   R+      + R++F G PR  RR  
Sbjct: 517 LHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRL-----NSIRNSFLGSPRFHRRKM 571

Query: 497 TYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKSRNVSAEQKD 554
                    SL+ E++P    RS      F    S L +    F  +K + +S+ + D
Sbjct: 572 QVPTAEEMSSLTPESSPELAKRS-----WFGNFIS-LDKEEQIFLVLKDKPLSSIKAD 623


>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
          Length = 668

 Score =  142 bits (359), Expect = 7e-34
 Identities = 67/134 (50%), Positives = 97/134 (72%)

Query: 47  ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRI 106
           A    ++G YRL KT+GKG    VKL  H +T ++VAIKI+++ +L+ + L K+ RE+ I
Sbjct: 10  AQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAI 69

Query: 107 MKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAV 166
           +K++ HP+++KL +V E +K LYL++E+ SGGE+FDYLV  GR+  KEAR  FRQI+SA+
Sbjct: 70  LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 129

Query: 167 QYCHQKRIVHRDLK 180
            +CH   I HRDLK
Sbjct: 130 DFCHSHSICHRDLK 143



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 57/244 (23%), Positives = 103/244 (42%), Gaps = 31/244 (12%)

Query: 178 DLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDEL 237
           +L++L E+V RG + +P ++  DC++LL+  + ++  +R TLE I K  W   G  E E 
Sbjct: 220 NLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEP 279

Query: 238 KPFVE--------PELDISDQKRIDIMVGMGYSQEE---IQESLSKMKYDEITATYLLLG 286
           +  +         P L+  D   +D M  +G  ++    +Q+ LS+ +  E    +LLL 
Sbjct: 280 EQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLD 339

Query: 287 RKS--SELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAG 344
           RK      +  D    + +   + R  S + N  G+    +    V S           G
Sbjct: 340 RKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLS-------VTDGG 392

Query: 345 PAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADI 404
             +P+  A            ++ + G  SR  SG++ G      +SP +    +P  + +
Sbjct: 393 SPVPARRAI-----------EMAQHGQRSRSISGASSGLSTSPLSSPRVTPHPSPRGSPL 441

Query: 405 PERK 408
           P  K
Sbjct: 442 PTPK 445


>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
           [Homo sapiens]
          Length = 552

 Score =  139 bits (349), Expect = 1e-32
 Identities = 66/140 (47%), Positives = 99/140 (70%), Gaps = 6/140 (4%)

Query: 47  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100
           A++Q H     IG+Y L  T+G G F KVK+  H LTG +VA+KI+++ ++    +  K+
Sbjct: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61

Query: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFR 160
            RE++ +K+  HP+I+KL++VI T    +++MEY SGGE+FDY+  HGR++E EAR  F+
Sbjct: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121

Query: 161 QIVSAVQYCHQKRIVHRDLK 180
           QI+SAV YCH+  +VHRDLK
Sbjct: 122 QILSAVDYCHRHMVVHRDLK 141



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 41/183 (22%), Positives = 75/183 (40%), Gaps = 14/183 (7%)

Query: 182 LRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFV 241
           L +++  G + IP Y++     LL   L ++P+KR T++ I +  W      + +L  ++
Sbjct: 222 LFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF-----KQDLPSYL 276

Query: 242 EPELDISDQKRID------IMVGMGYSQEEIQESL-SKMKYDEITATY-LLLGRKSSELD 293
            PE    D   ID      +      ++ E+  SL S    D++   Y L++  +     
Sbjct: 277 FPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQ 336

Query: 294 ASDSSSSSNLSLAKVRPSSDLNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGPAIPSVVA 352
           AS+   +S+         S ++   G  PH  ++   +  S K R   D      P  +A
Sbjct: 337 ASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLA 396

Query: 353 YPK 355
             K
Sbjct: 397 VKK 399


>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 1 [Homo sapiens]
          Length = 559

 Score =  137 bits (344), Expect = 4e-32
 Identities = 64/140 (45%), Positives = 100/140 (71%), Gaps = 6/140 (4%)

Query: 47  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100
           A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VA+KI+++ ++    +  K+
Sbjct: 13  AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 72

Query: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFR 160
            RE++ +K+  HP+I+KL++VI T   ++++MEY SGGE+FDY+  +GR+ EKE+R  F+
Sbjct: 73  RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQ 132

Query: 161 QIVSAVQYCHQKRIVHRDLK 180
           QI+S V YCH+  +VHRDLK
Sbjct: 133 QILSGVDYCHRHMVVHRDLK 152



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 39/173 (22%), Positives = 73/173 (42%), Gaps = 20/173 (11%)

Query: 182 LRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFV 241
           L +++  G +  P Y++    +LLK  L ++P+KR T++ I +  W      + +L  ++
Sbjct: 233 LFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF-----KQDLPKYL 287

Query: 242 EPE------LDISDQKRIDIMVGMGYSQEEIQESLSKMKYDE--ITATYLLLGRKSSELD 293
            PE        I D+   ++      S+EE+   L    + +    A +L++  +    +
Sbjct: 288 FPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNE 347

Query: 294 ASDSSSSSNLSLAKVRPSSDLNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGP 345
           A D        LA   P S L++     PH  +V   V  + + R   D   P
Sbjct: 348 AKD------FYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP 394


>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
          Length = 436

 Score =  134 bits (336), Expect = 3e-31
 Identities = 65/128 (50%), Positives = 94/128 (73%)

Query: 53  IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
           IG YR+   IG GNF++VKL  H LT  +VAIKI+DKT+L+  + + L RE+  M+ L+H
Sbjct: 71  IGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHH 130

Query: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
           PNI++L+EV+ET   L+L+MEYA GGE+F  +   G++ E E++  F QIVSAV++ H+ 
Sbjct: 131 PNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHEN 190

Query: 173 RIVHRDLK 180
           +I+HRDLK
Sbjct: 191 QIIHRDLK 198



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 27/125 (21%), Positives = 55/125 (44%), Gaps = 8/125 (6%)

Query: 181 ELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPF 240
           +L++ +L G Y +P ++S  C  L++  L   P +R  ++ IM D W+        L+PF
Sbjct: 278 KLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIPTERYGIDCIMNDEWMQGVPYPTPLEPF 337

Query: 241 VEPELDISDQKRI--------DIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSEL 292
                 +S+   +          +  +G ++E I+ +  +     IT  Y ++  +    
Sbjct: 338 QLDPKHLSETSTLKEEENEVKSTLEHLGITEEHIRNNQGRDARSSITGVYRIILHRVQRK 397

Query: 293 DASDS 297
            A +S
Sbjct: 398 KALES 402


>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
          Length = 661

 Score =  130 bits (326), Expect = 5e-30
 Identities = 133/527 (25%), Positives = 214/527 (40%), Gaps = 83/527 (15%)

Query: 8   PTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNF 67
           P   +R      + G  R+ V   T+    R  + +     +      Y L +T+GKG +
Sbjct: 7   PVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTY 66

Query: 68  AKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKLFEVIETEK 126
            KVK A    +GR VAIK I K ++ +   +  + RE+ IM  LNHP+I+ ++EV E + 
Sbjct: 67  GKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKD 126

Query: 127 TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKELRERV 186
            + +IMEYAS GE++DY+    R+ E+E R  FRQIVSAV YCH+  +VHRDLK   E +
Sbjct: 127 KIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLK--LENI 184

Query: 187 LRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELD 246
           L         +  +C   +  F + N  ++    Q      + A  E    +P+  PE+D
Sbjct: 185 L---------LDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVD 235

Query: 247 I-------------------SDQKRIDIMVGMGYSQEEIQESLSK-------MKYDEITA 280
                                D K +   +  G  +E  Q S ++       M   +  A
Sbjct: 236 SWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRA 295

Query: 281 T--------YLLLGRKSSELDASDSSSSSNLSLAKV---------------RPSSDLNNS 317
           T        ++  G KSS  D      S +  LA++                    L   
Sbjct: 296 TIEDIANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAKP 355

Query: 318 TGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSS 377
           T      + QRS+  S+K+  ++     A+P     P +  +      LK+   S  +S 
Sbjct: 356 TTSEVMLERQRSLKKSKKENDFAQSGQDAVPE---SPSKLSSKRPKGILKKRSNSEHRSH 412

Query: 378 GSAVGGKGIAPASPMLGN------------ASNPNKADIPER---KKSSTVPSSNTASGG 422
            +      + PA P                 S+P +A++P +   K+S+T+P        
Sbjct: 413 STGFIEGVVGPALPSTFKMEQDLCRTGVLLPSSP-EAEVPGKLSPKQSATMPKKGILKKT 471

Query: 423 MTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTP---VASTHSIS 466
             R + Y  S   +     +  N    S+IP    P     ++HS+S
Sbjct: 472 QQRESGYYSSPERSESSELLDSNDVMGSSIPSPSPPDPARVTSHSLS 518


>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 2 [Homo sapiens]
          Length = 574

 Score =  127 bits (318), Expect = 4e-29
 Identities = 64/155 (41%), Positives = 100/155 (64%), Gaps = 21/155 (13%)

Query: 47  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100
           A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VA+KI+++ ++    +  K+
Sbjct: 13  AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 72

Query: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR----------- 149
            RE++ +K+  HP+I+KL++VI T   ++++MEY SGGE+FDY+  +GR           
Sbjct: 73  RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTG 132

Query: 150 ----MKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
               + EKE+R  F+QI+S V YCH+  +VHRDLK
Sbjct: 133 STKELDEKESRRLFQQILSGVDYCHRHMVVHRDLK 167



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 39/173 (22%), Positives = 73/173 (42%), Gaps = 20/173 (11%)

Query: 182 LRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFV 241
           L +++  G +  P Y++    +LLK  L ++P+KR T++ I +  W      + +L  ++
Sbjct: 248 LFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF-----KQDLPKYL 302

Query: 242 EPE------LDISDQKRIDIMVGMGYSQEEIQESLSKMKYDE--ITATYLLLGRKSSELD 293
            PE        I D+   ++      S+EE+   L    + +    A +L++  +    +
Sbjct: 303 FPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNE 362

Query: 294 ASDSSSSSNLSLAKVRPSSDLNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGP 345
           A D        LA   P S L++     PH  +V   V  + + R   D   P
Sbjct: 363 AKD------FYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP 409


>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
          Length = 651

 Score =  127 bits (318), Expect = 4e-29
 Identities = 63/125 (50%), Positives = 86/125 (68%), Gaps = 1/125 (0%)

Query: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115
           Y L +TIG G FAKVKLA HILTG  VAIKI+DK  L  + L ++  E+  +K L H +I
Sbjct: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLRHQHI 69

Query: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 175
            +L+ V+ET   +++++EY  GGE+FDY+++  R+ E+E R  FRQIVSAV Y H +   
Sbjct: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129

Query: 176 HRDLK 180
           HRDLK
Sbjct: 130 HRDLK 134



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 102/485 (21%), Positives = 199/485 (41%), Gaps = 57/485 (11%)

Query: 182 LRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFV 241
           L ++++RGKY +P ++S     LL++ L ++P KR +++ ++   WI   +         
Sbjct: 217 LYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSK 276

Query: 242 EPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATY-LLLGRKSSELDASDSSSS 300
            P + + D    ++ V    +++ +++ +S  +YD +TATY LLL +K+         SS
Sbjct: 277 NPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSS 336

Query: 301 SNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTS 360
            +   A   P +D+ ++                            ++  V A  K     
Sbjct: 337 FSCGQASATPFTDIKSNNW--------------------------SLEDVTASDKNYVAG 370

Query: 361 TADSDLKEDGISS-----RKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPS 415
             D D  ED +S+     R S  +    +     S  L  A     A+  + K++   P 
Sbjct: 371 LIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPK 430

Query: 416 SNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIR 475
           S      +     ++  E  T    +  Q+ +E  T P++ T  +   +     TP +I 
Sbjct: 431 S-----AVKNEEYFMFPEPKTPVNKN--QHKREILTTPNRYTTPSKARNQCLKETPIKIP 483

Query: 476 F-PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLT 534
               GT    T    P ERR         S  L      + +T  R    +F  L   L 
Sbjct: 484 VNSTGTDKLMTGVISP-ERRC-------RSVELDLNQAHMEETPKRKGAKVFGSLERGLD 535

Query: 535 RRNMSFRFIKSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNC 594
           +       + +    +++K   ++  PR L+  +++ TT  ++P  ++ EI  +L   + 
Sbjct: 536 K-------VITVLTRSKRKGSARDG-PRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHV 587

Query: 595 DYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIA 654
           D+ Q+  + L C       +  +Q+E+EVC+L +  + G+R +R+ G +  +K +   I 
Sbjct: 588 DFVQK-GYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDIL 646

Query: 655 NELKL 659
           +  K+
Sbjct: 647 SSCKV 651


>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
          Length = 628

 Score =  124 bits (310), Expect = 4e-28
 Identities = 63/126 (50%), Positives = 86/126 (68%), Gaps = 2/126 (1%)

Query: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPN 114
           Y  L+T+GKG + KVK AR   +GR VAIK I K ++ +   L  + RE+ IM  LNHP+
Sbjct: 53  YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111

Query: 115 IVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRI 174
           I+ + EV E    + ++MEYAS G+++DY+    ++ E+EAR  FRQIVSAV YCHQ R+
Sbjct: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171

Query: 175 VHRDLK 180
           VHRDLK
Sbjct: 172 VHRDLK 177



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 20/55 (36%), Positives = 31/55 (56%), Gaps = 1/55 (1%)

Query: 178 DLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGH 232
           D K L +++  G YR P   S  C  L++  L++NP +R TLE +    W+N G+
Sbjct: 254 DHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTRRATLEDVASHWWVNWGY 307


>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
           sapiens]
          Length = 714

 Score =  113 bits (282), Expect = 6e-25
 Identities = 58/138 (42%), Positives = 91/138 (65%), Gaps = 5/138 (3%)

Query: 48  DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL--QKLFR 102
           D Q H  +GNY +  + +G+G+FAKV+   H+LTG +VAIK+IDK +    +   + L R
Sbjct: 51  DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110

Query: 103 EVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQI 162
           E +I +++ HPNI +L +++ETE + YL+ME   GG +   +    R++E EAR   RQ+
Sbjct: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170

Query: 163 VSAVQYCHQKRIVHRDLK 180
           +SAV++ H+  +VHRDLK
Sbjct: 171 ISAVEHLHRAGVVHRDLK 188



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 27/114 (23%), Positives = 50/114 (43%), Gaps = 9/114 (7%)

Query: 193 IPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPEL----DIS 248
           +P  +ST   + L+  L  +P+KR  ++Q + +RW+N  +          P      D+S
Sbjct: 285 LPTQLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLS 344

Query: 249 DQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRK-----SSELDASDS 297
               + +   +GY   ++  ++   +   I A Y LL +K     S + D  DS
Sbjct: 345 PSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDS 398


>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
           isoform 2 [Homo sapiens]
          Length = 478

 Score =  105 bits (263), Expect = 1e-22
 Identities = 55/125 (44%), Positives = 79/125 (63%)

Query: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115
           Y+L + +GKG F+ V+    +L G+E A KII+  +L+    QKL RE RI ++L HPNI
Sbjct: 13  YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 72

Query: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 175
           V+L + I  E   YLI +  +GGE+F+ +VA     E +A    +QI+ AV +CHQ  +V
Sbjct: 73  VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 132

Query: 176 HRDLK 180
           HRDLK
Sbjct: 133 HRDLK 137



 Score = 30.0 bits (66), Expect = 7.1
 Identities = 15/56 (26%), Positives = 29/56 (51%), Gaps = 4/56 (7%)

Query: 178 DLKELRERVLRGKYRIPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWIN 229
           D   L +++  G Y  P      ++ + ++L+ + L +NP KR T  + +K  WI+
Sbjct: 217 DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272


>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
           isoform 1 [Homo sapiens]
          Length = 489

 Score =  105 bits (263), Expect = 1e-22
 Identities = 55/125 (44%), Positives = 79/125 (63%)

Query: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115
           Y+L + +GKG F+ V+    +L G+E A KII+  +L+    QKL RE RI ++L HPNI
Sbjct: 13  YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 72

Query: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 175
           V+L + I  E   YLI +  +GGE+F+ +VA     E +A    +QI+ AV +CHQ  +V
Sbjct: 73  VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 132

Query: 176 HRDLK 180
           HRDLK
Sbjct: 133 HRDLK 137



 Score = 30.0 bits (66), Expect = 7.1
 Identities = 15/56 (26%), Positives = 29/56 (51%), Gaps = 4/56 (7%)

Query: 178 DLKELRERVLRGKYRIPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWIN 229
           D   L +++  G Y  P      ++ + ++L+ + L +NP KR T  + +K  WI+
Sbjct: 217 DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272


>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
           isoform 4 [Homo sapiens]
          Length = 489

 Score =  103 bits (257), Expect = 5e-22
 Identities = 54/125 (43%), Positives = 78/125 (62%)

Query: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115
           Y+L + +GKG F+ V+    I TG+E A KII+  +L+    QKL RE RI ++L HPNI
Sbjct: 14  YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73

Query: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 175
           V+L + I  E   YL+ +  +GGE+F+ +VA     E +A    +QI+ +V +CH   IV
Sbjct: 74  VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133

Query: 176 HRDLK 180
           HRDLK
Sbjct: 134 HRDLK 138



 Score = 30.4 bits (67), Expect = 5.4
 Identities = 15/55 (27%), Positives = 28/55 (50%), Gaps = 4/55 (7%)

Query: 178 DLKELRERVLRGKYRIPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 228
           D   L +++  G Y  P      ++ + ++L+ + L +NP KR T  + +K  WI
Sbjct: 218 DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.128    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,851,924
Number of Sequences: 37866
Number of extensions: 1066632
Number of successful extensions: 5570
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 536
Number of HSP's successfully gapped in prelim test: 325
Number of HSP's that attempted gapping in prelim test: 3536
Number of HSP's gapped (non-prelim): 1494
length of query: 659
length of database: 18,247,518
effective HSP length: 109
effective length of query: 550
effective length of database: 14,120,124
effective search space: 7766068200
effective search space used: 7766068200
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.