Guide to the Human Genome
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Search of human proteins with 190610010

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|190610010 hypothetical protein LOC317761 [Homo sapiens]
         (587 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|190610010 hypothetical protein LOC317761 [Homo sapiens]           1187   0.0  
gi|83715968 sarcoma antigen NY-SAR-79 [Homo sapiens]                   50   6e-06
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     48   2e-05
gi|55770834 centromere protein F [Homo sapiens]                        46   8e-05
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  46   1e-04
gi|51972208 leucine, glutamate and lysine rich 1 [Homo sapiens]        45   1e-04
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    45   2e-04
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]    44   5e-04
gi|225579095 S-phase cyclin A-associated protein in the ER isofo...    44   5e-04
gi|225579092 S-phase cyclin A-associated protein in the ER isofo...    44   5e-04
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    43   0.001
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    43   0.001
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]               42   0.001
gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]           42   0.001
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             42   0.002
gi|64085252 hypothetical protein LOC145508 [Homo sapiens]              42   0.002
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    42   0.002
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [...    42   0.002
gi|33946313 ninein isoform 4 [Homo sapiens]                            42   0.002
gi|33946321 ninein isoform 5 [Homo sapiens]                            42   0.002
gi|148536871 ninein isoform 1 [Homo sapiens]                           42   0.002
gi|148536869 ninein isoform 2 [Homo sapiens]                           42   0.002
gi|71061468 centromere protein E [Homo sapiens]                        41   0.003
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]    41   0.003
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]    41   0.003
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...    40   0.006
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    40   0.006
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]    40   0.006
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...    40   0.006
gi|110815815 centlein isoform 1 [Homo sapiens]                         40   0.008

>gi|190610010 hypothetical protein LOC317761 [Homo sapiens]
          Length = 587

 Score = 1187 bits (3071), Expect = 0.0
 Identities = 587/587 (100%), Positives = 587/587 (100%)

Query: 1   MNDSLFVSLDRLLLEFVFQYEQDISTKEEMIQRINKCCEDIKENKVTICRIHETINATDE 60
           MNDSLFVSLDRLLLEFVFQYEQDISTKEEMIQRINKCCEDIKENKVTICRIHETINATDE
Sbjct: 1   MNDSLFVSLDRLLLEFVFQYEQDISTKEEMIQRINKCCEDIKENKVTICRIHETINATDE 60

Query: 61  EIDHYCKHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKE 120
           EIDHYCKHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKE
Sbjct: 61  EIDHYCKHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKE 120

Query: 121 VLKQYQLKYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTK 180
           VLKQYQLKYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTK
Sbjct: 121 VLKQYQLKYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTK 180

Query: 181 WTLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETL 240
           WTLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETL
Sbjct: 181 WTLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETL 240

Query: 241 EEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADI 300
           EEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADI
Sbjct: 241 EEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADI 300

Query: 301 KEESSAKQSKLANIDFRQKENDTQIFNDSAVDNHSKCSHITTITSSQKFMQVRLLTPQKQ 360
           KEESSAKQSKLANIDFRQKENDTQIFNDSAVDNHSKCSHITTITSSQKFMQVRLLTPQKQ
Sbjct: 301 KEESSAKQSKLANIDFRQKENDTQIFNDSAVDNHSKCSHITTITSSQKFMQVRLLTPQKQ 360

Query: 361 SNSNQWSEKGDKDAEYGDKGTVRQVRESKCTSQAIYTEHFGKSIENDSDEVEERAENFPR 420
           SNSNQWSEKGDKDAEYGDKGTVRQVRESKCTSQAIYTEHFGKSIENDSDEVEERAENFPR
Sbjct: 361 SNSNQWSEKGDKDAEYGDKGTVRQVRESKCTSQAIYTEHFGKSIENDSDEVEERAENFPR 420

Query: 421 TSEIPIFLGTPKAVKAPESLEKIKFPKTPPFEINRNRNAVPEVQTEKESPGLSFLMSYTS 480
           TSEIPIFLGTPKAVKAPESLEKIKFPKTPPFEINRNRNAVPEVQTEKESPGLSFLMSYTS
Sbjct: 421 TSEIPIFLGTPKAVKAPESLEKIKFPKTPPFEINRNRNAVPEVQTEKESPGLSFLMSYTS 480

Query: 481 RSPGLNLFDSSVFDTEISSDQFNEHYSARNLNPLSSEQEIGNLLEKPEGEDGFTFSFPSD 540
           RSPGLNLFDSSVFDTEISSDQFNEHYSARNLNPLSSEQEIGNLLEKPEGEDGFTFSFPSD
Sbjct: 481 RSPGLNLFDSSVFDTEISSDQFNEHYSARNLNPLSSEQEIGNLLEKPEGEDGFTFSFPSD 540

Query: 541 TSTHTFGAGKDDFSFPFSFGQGQNSIPSSSLKGFSSSSQNTTQFTFF 587
           TSTHTFGAGKDDFSFPFSFGQGQNSIPSSSLKGFSSSSQNTTQFTFF
Sbjct: 541 TSTHTFGAGKDDFSFPFSFGQGQNSIPSSSLKGFSSSSQNTTQFTFF 587


>gi|83715968 sarcoma antigen NY-SAR-79 [Homo sapiens]
          Length = 1079

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 128/597 (21%), Positives = 233/597 (39%), Gaps = 111/597 (18%)

Query: 4   SLFVSLDRLLL--EFVFQYEQDISTKEEMIQRINKCCEDIKENKVTICRIHETINAT--- 58
           SL  +L+ L +  E    YE+ I       Q +    E ++  K T+   H+   A    
Sbjct: 33  SLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKK 92

Query: 59  ---------DEEIDHYCKHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKE 109
                    +EE   Y   +E  +      K T    +  +  +Q + +  +  V+    
Sbjct: 93  QLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLL 152

Query: 110 MYHDYICQYKEVLKQYQLKYSETPFSREYYEKKREH--EEIQSR-------------VLA 154
              DY  Q  E+ K Y     +    +E +EK  ++  E IQS              + +
Sbjct: 153 AKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICS 212

Query: 155 CTEQLKMNETIFMKFRVPAPFPSLTKWTLNIVNLRCETQDILKHASNLTKSSSELKKEV- 213
             ++LK   +  +K +V   +  + +  +N+     + Q++ +  +   + + ++ +E+ 
Sbjct: 213 LKKELKKAASDLIKSKVTCQY-KMGEENINLTIKEQKFQELQERLNMELELNEKINEEIT 271

Query: 214 ----DEMEIEINY------LNQQISRHNETKALSETLEEKNKNTENRKEL-KERIFGKDE 262
               ++ +I I++      L QQI  + E +A  + L+E N+  E   EL +E++   +E
Sbjct: 272 HIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEE 331

Query: 263 HVLTLNKTQSSQLFLPYESQKLVRPIKMHSSE--PRVADIKEE-SSAKQSKLANIDFRQK 319
             L L            E +K +   K H+ E    +  IK E SS K++ +   +   K
Sbjct: 332 KFLNLQN----------EHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNK 381

Query: 320 -------ENDTQIFNDSAVDNHSKCSHITTITSSQKFMQVRLLTPQKQSNSNQWSEKGDK 372
                  E D +  N   V+N +  S ++T  S    +Q +  T Q+    N   E    
Sbjct: 382 LCNQKTFEEDKKFQNVPEVNNEN--SEMSTEKSENTIIQ-KYNTEQEIREENM--ENFCS 436

Query: 373 DAEYGDKGTVRQVRESKCTSQAIY--TEHFGKSIENDSDEVEERAENFPRTSEIPIFLGT 430
           D EY +K    + +E     + I    + F KS +N+ D V  + EN    SEI      
Sbjct: 437 DTEYREK---EEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDEN---QSEI------ 484

Query: 431 PKAVKAPESLEKIKFPKTPPFEINRNRNAV-PEVQ-----------TEKESPGLSFLMSY 478
             ++    SL+K    +     +  NR +V  E++           TE +SP   F++  
Sbjct: 485 --SLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLD 542

Query: 479 TS---------RSPGLNLFDSSV-FDTEISSDQFNE------HYSARNLNPLSSEQE 519
           T+         R+ GL++  + V  + E +   FN       H +  N N   SE E
Sbjct: 543 TAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSENE 599


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 78/414 (18%), Positives = 166/414 (40%), Gaps = 45/414 (10%)

Query: 27   KEEMIQRINKCCEDIKENKVTICRIHETINATDEEIDHYCKHSEEIKDNCRNWKPTCDVF 86
            KEEM + I    E+  +   T+  + E +      ++   +   ++K +    +   +  
Sbjct: 1087 KEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKS 1146

Query: 87   RKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQ-LKYSETPFSREYYEKKREH 145
             K   ++Q+Q    +   E+DK    +   + K   +++Q LK S    ++   +K  E 
Sbjct: 1147 LKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEF 1206

Query: 146  EEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKWTLNIVNLRCETQDILKHASNLTKS 205
            +++       +E+L +   I  K +  A   + T   +NI +   +T  IL   S+    
Sbjct: 1207 KKL-------SEELAIQLDICCK-KTEALLEAKTNELINISS--SKTNAILSRISHCQHR 1256

Query: 206  SSELKK-------EVDEMEIEINYLNQQISRHN-ETKALSETLEEKNKNTENRKELKERI 257
            ++++K+        V E+E ++  L ++ +  N   +  +  LEEK    ++ K   E +
Sbjct: 1257 TTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESL 1316

Query: 258  FGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSE--PRVADIKEESSAKQSKLANID 315
              + E    L K   +Q     E +  +  +K   SE    V  +KEE   K+ +++++ 
Sbjct: 1317 VTEKE---ALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLS 1373

Query: 316  FRQKENDTQIFNDSAVD-------------NHSKCSHITTITSSQKFMQVRLLTPQKQSN 362
             +  + + Q+ N  ++              +  KC  +  +       +V  L+ +K S 
Sbjct: 1374 KQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLS--FKVDTLSKEKISA 1431

Query: 363  SNQWSEKGDKDAEYGDKGTVRQVRESKCTSQAIYTEHFGKSIENDSDEVEERAE 416
              Q  +  +K +E+  K       +S+ T      +     +E  S E  E+ E
Sbjct: 1432 LEQVDDWSNKFSEWKKKA------QSRFTQHQNTVKELQIQLELKSKEAYEKDE 1479



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 76/408 (18%), Positives = 167/408 (40%), Gaps = 38/408 (9%)

Query: 21  EQDISTKEEMIQRINKCCEDIKENKVTICRIHETINATDEEIDHYCKHSEEIKDNCRNWK 80
           +Q +  +E +++R   C E I+ +K     +     A  E++D   +  E+IKD     K
Sbjct: 285 QQRVKRQENLLKR---CKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEK 341

Query: 81  PTC-----DVFRKHEDYMQDQFTVYQGT---VEKDKEMYHDYICQYKEVLKQYQLKYSET 132
                   D     E   QD+  V   T   + +  EM  + I Q +  +KQ   +  E 
Sbjct: 342 TKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEEL 401

Query: 133 PFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKWT-LNIVNLRCE 191
              +E  E +   EE++  +   T Q        +K  +     ++ K +    ++L+ E
Sbjct: 402 REQKEKSE-RAAFEELEKAL--STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQE 458

Query: 192 TQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETLEEKNKNTENRK 251
              + +   ++ K SSE      E   ++  L+++     E + L++ L+ + +  E ++
Sbjct: 459 LSRVKQEVVDVMKKSSE------EQIAKLQKLHEKELARKE-QELTKKLQTRER--EFQE 509

Query: 252 ELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADIKEESSAKQSKL 311
           ++K  +       L +++ +  Q  L  E  +L +   +  SE ++ D+++E+   ++++
Sbjct: 510 QMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRI 569

Query: 312 ANIDF---------RQKENDTQIFNDSAVDNHSK-----CSHITTITSSQKFMQVRLLTP 357
             ++          + +  D  +  ++  + H+K          T   S K  Q  L T 
Sbjct: 570 LELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTE 629

Query: 358 QKQSNSNQWSEKGDKDAEYGDKGTVRQVRESKCTSQAIYTEHFGKSIE 405
           + Q    Q+  + +K  E  ++     +++ +   QA   E   K++E
Sbjct: 630 KLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLE 677



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 69/317 (21%), Positives = 129/317 (40%), Gaps = 60/317 (18%)

Query: 8    SLDRLLLEFVFQYEQDIST--KEEMIQRINKCCEDIKENKVTICRIHETINATDEEIDHY 65
            SL + L +   Q +  IS   KE  I  + K  ++ K      C + + +     ++D  
Sbjct: 1371 SLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEK------CELLDQVQDLSFKVDTL 1424

Query: 66   CKHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQY 125
             K      +   +W    + F + +   Q +FT +Q TV              KE+  Q 
Sbjct: 1425 SKEKISALEQVDDWS---NKFSEWKKKAQSRFTQHQNTV--------------KELQIQL 1467

Query: 126  QLKYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIF--MKFRVPAPFPSLTKWTL 183
            +LK      S+E YEK  +   ++       E+L      F  +K  +      + K   
Sbjct: 1468 ELK------SKEAYEKDEQINLLK-------EELDQQNKRFDCLKGEMEDDKSKMEKKES 1514

Query: 184  NI-VNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKAL--SETL 240
            N+   L+ +T  I+           EL+  + +  IEI  LN+ +  +N+ K +   E +
Sbjct: 1515 NLETELKSQTARIM-----------ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELV 1563

Query: 241  EEKNKNTENRKELKERIFGKDEHVLTL-NKTQSSQLFLPYESQKLVR---PIKMHSSEPR 296
            ++     E  +E   R+   +E +LTL N+  S +  L  + ++L      +K    E +
Sbjct: 1564 QKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELK 1623

Query: 297  VAD--IKEESSAKQSKL 311
              +  ++ ES+AK ++L
Sbjct: 1624 ALEDRLESESAAKLAEL 1640



 Score = 33.9 bits (76), Expect = 0.43
 Identities = 70/383 (18%), Positives = 149/383 (38%), Gaps = 37/383 (9%)

Query: 2   NDSLFVSLDRLLLEFVFQYEQDISTKEEMIQRINKCCEDIKENKVTICRIHETINATDEE 61
           ++ L +S ++   E +   E ++  K  + +  NK  +  +E +    RI E  ++ ++ 
Sbjct: 520 SEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKS 579

Query: 62  IDHYCKHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEV 121
           +      S+++  +    K       KH   +      ++  +E  K        +  +V
Sbjct: 580 LQENKNQSKDLAVHLEAEK------NKHNKEITVMVEKHKTELESLKHQQDALWTEKLQV 633

Query: 122 LKQ-YQLKYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTK 180
           LKQ YQ +  +    RE  E+++E       ++      +MNE    K  V         
Sbjct: 634 LKQQYQTEMEKL---REKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQT------ 684

Query: 181 WTLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETL 240
               + +L  E  ++LK    L +  S LK + D+M+ E+     +   H++ +  S   
Sbjct: 685 ---ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIK 741

Query: 241 EEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADI 300
           E +       K LK++I   ++  L L +            + L   IK    E + A  
Sbjct: 742 EHEVSIQRTEKALKDQI---NQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASA 798

Query: 301 K------------EESSAKQSKLANIDFRQKENDTQ--IFNDSAVDNHSKCSHITTITSS 346
           K            E++ A + +LA +  +  + +T+  +      +  ++   + T   +
Sbjct: 799 KLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDA 858

Query: 347 QKFMQVRLLTPQKQSNSNQWSEK 369
            K +QV+ L  Q +  +++  +K
Sbjct: 859 HK-IQVQDLMQQLEKQNSEMEQK 880


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 97/441 (21%), Positives = 173/441 (39%), Gaps = 57/441 (12%)

Query: 13  LLEFVFQYEQDISTKEEMIQRINKCCEDI---KENKVTI-CRIHETINATD----EEIDH 64
           L+    QY+Q  +    + Q++ K  ED+   ++N  +  C + + I   +    EE+  
Sbjct: 343 LVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSR 402

Query: 65  YCKHSEEIKDNCRNWKPTCDVFRKHEDYMQ-------DQFTVYQGTVEKDKEMYHDYICQ 117
             +  + +   C   K       +    M        D+ T  +  +E + E +   +C+
Sbjct: 403 QQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCR 462

Query: 118 YKEVLKQYQLKYSETPFSREYYEKK----REHEEIQSRVLACTEQLKMNETIFMKFRVPA 173
            ++  +  Q+K +E   S E  +K+    + H E ++R +   E    N    +      
Sbjct: 463 AEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNF 522

Query: 174 PFPSLTKWTLNIVNLRCETQDILKHASNLTKSS-----SELKKEVD-------EMEIEIN 221
                 K T     LR   + I +  ++LT        ++L+K+ D       + E  I 
Sbjct: 523 AEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIE 582

Query: 222 YLNQQISR-HNETKALSETLEEKNKNTENRKELKERIF---GKDEHVLTLNKTQSSQL-- 275
            LN ++S+   E+KAL   LE K K  E  KE K        ++E +LT  +++   L  
Sbjct: 583 QLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQS 642

Query: 276 -FLPYESQKLVRPIKMHSSEPRVADI---KEESSAKQSKLANI-DFRQKENDTQIF---- 326
                E+    + IK H    RV  +   +E  S +   L N+ D +  E +TQ      
Sbjct: 643 KINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYME 702

Query: 327 ----NDSAVDNHSKCSHITTITSSQKFMQVRLLTPQKQSNSNQWSEKG----DKDAEYGD 378
                + +   H K      + +SQ   QV  L  + Q  SN+  +K     D  AEY  
Sbjct: 703 LQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEY-- 760

Query: 379 KGTVRQVRESKCTSQAIYTEH 399
             ++R + +SK  S     +H
Sbjct: 761 -ESLRDLLKSKDASLVTNEDH 780



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 53/272 (19%), Positives = 115/272 (42%), Gaps = 44/272 (16%)

Query: 9    LDRLLLEFVFQYEQ----DISTKEEM---IQRINKCCEDIKENKVTICRIHETINATDEE 61
            LD+LL  F    E+    +I  KEE    ++ +    +++ E    +C   E + AT++ 
Sbjct: 2229 LDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQS 2288

Query: 62   IDHYCKHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEV 121
            +D   +   +++++    +   +   K +  +  Q         K+ E + D +    E 
Sbjct: 2289 LDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQL--------KESEHHADLLKGRVEN 2340

Query: 122  LKQYQLKYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKW 181
            L++ +L+ + T          +EH  +++       +    E   +K ++     SL   
Sbjct: 2341 LER-ELEIART---------NQEHAALEA-------ENSKGEVETLKAKIEGMTQSLRGL 2383

Query: 182  TLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETLE 241
             L++V +R E +       NLT    + ++ + E+EI IN   + I +  E     E ++
Sbjct: 2384 ELDVVTIRSEKE-------NLTNELQKEQERISELEI-INSSFENILQEKE----QEKVQ 2431

Query: 242  EKNKNTENRKELKERIFGKDEHVLTLNKTQSS 273
             K K++   + L+ ++   +E V  L+  Q +
Sbjct: 2432 MKEKSSTAMEMLQTQLKELNERVAALHNDQEA 2463



 Score = 33.1 bits (74), Expect = 0.73
 Identities = 46/211 (21%), Positives = 81/211 (38%), Gaps = 39/211 (18%)

Query: 12   LLLEFVFQYEQDISTKEEMIQRINKCC--------------EDIKENKVTICRIHETINA 57
            LLL+   QYE +I T  E +    +C               E++  +     +I E +  
Sbjct: 2713 LLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKK 2772

Query: 58   TDEE----IDHYCKHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDK----- 108
            T  +    ++   K +E  +   +    +C    + ++ +Q + +  Q   EK K     
Sbjct: 2773 TKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVM 2832

Query: 109  ----EMYHDYICQYKEVLK-------QYQLKYSETPFSREYYEKKREHEEIQSRVLACTE 157
                +     I + KE L+       +Y  KY     S E  EK +E  E Q   L C++
Sbjct: 2833 DTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHL-CSQ 2891

Query: 158  QLKMNE----TIFMKFRVPAPFPSLTKWTLN 184
            Q K +      +      P+P PS+T+  L+
Sbjct: 2892 QSKQDSRGSPLLGPVVPGPSPIPSVTEKRLS 2922



 Score = 32.7 bits (73), Expect = 0.95
 Identities = 29/105 (27%), Positives = 48/105 (45%), Gaps = 14/105 (13%)

Query: 208  ELKKEVDEMEIEINYLNQQISRHNETKALSETLEEKNKNTENRKELKERIFGKDEHVLTL 267
            EL+    E+E +I  L  + +   +T    E L+   KN EN  EL +    K   V  +
Sbjct: 2557 ELRNLTVELEQKIQVLQSKNASLQDTL---EVLQSSYKNLENELELTK--MDKMSFVEKV 2611

Query: 268  NKTQSSQLFLPYESQKLVRPIKMHSSEPRVADIKEESSAKQSKLA 312
            NK  + +  L  E         MH    + A+++EE S ++++LA
Sbjct: 2612 NKMTAKETELQRE---------MHEMAQKTAELQEELSGEKNRLA 2647



 Score = 30.8 bits (68), Expect = 3.6
 Identities = 41/195 (21%), Positives = 78/195 (40%), Gaps = 18/195 (9%)

Query: 187 NLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETLEEKNKN 246
           NL+ E Q +++   +L K+  ++  E+   E ++N+   Q+   N  K   E LE++ K 
Sbjct: 64  NLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQL---NSGKKQIEKLEQELKR 120

Query: 247 TENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADIKE---- 302
            ++  E  ++     +  L    T       P      + P + +S   +  D+KE    
Sbjct: 121 CKSELERSQQAAQSADVSLNPCNTPQKIFTTP------LTPSQYYSGS-KYEDLKEKYNK 173

Query: 303 ESSAKQSKLANIDFRQKENDTQIFNDSAVDNHSKCSHITTITSSQKFMQVRLLTPQK-QS 361
           E   ++   A +   Q +  +Q    + +++     H     SS  F   +  TP    S
Sbjct: 174 EVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARH---QASSSVFSWQQEKTPSHLSS 230

Query: 362 NSNQWSEKGDKDAEY 376
           NS +   + D  A Y
Sbjct: 231 NSQRTPIRRDFSASY 245


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 72/411 (17%), Positives = 153/411 (37%), Gaps = 82/411 (19%)

Query: 23   DISTKEEMIQRINKCCEDIKENKVTICRIHETINATDEEIDHYCKHSE-------EIKDN 75
            DIS  ++ +Q   +    ++E    +  + + +N   +++ H  KH +        ++ +
Sbjct: 1851 DISAMQQQLQEKREAVNSLQEE---LANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKD 1907

Query: 76   CRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQLKYSETPFS 135
               W    +  +K E+  Q Q  V Q  +E++K                 +L   E  F 
Sbjct: 1908 ISEWANRFEDCQKEEETKQQQLQVLQNEIEENK----------------LKLVQQEMMFQ 1951

Query: 136  REYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKWTLNIVNLRCETQDI 195
            R   E++ E  ++++  +   EQ                                     
Sbjct: 1952 RLQKERESEESKLETSKVTLKEQ------------------------------------- 1974

Query: 196  LKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETLEEKNKNTENR-KELK 254
                  L K  ++ K ++D++  ++    +++    E +   E+LE+    T+ +  E +
Sbjct: 1975 ---QHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSERE 2031

Query: 255  ERIFGKDEHVLTLNKTQSSQL--FLPYESQKLVRPIKMHSSEPRVADIKEESSAKQSKLA 312
            +++  K   +L L K   S    F    +Q L    K   +E +VA +KE    ++S+L 
Sbjct: 2032 QQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKK---AEKQVASLKEALKIQRSQLE 2088

Query: 313  NIDFRQKENDTQIFNDSAV------DNHSKCSHITTITSSQKFMQVRLLTPQKQSNSNQW 366
                 QK+ ++ I  + A       DNH +   +    +  ++    L   +KQ  + + 
Sbjct: 2089 KNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTEL---KKQMANQKD 2145

Query: 367  SEKGDKDAEYGDKGTVRQVRESKCTSQAIYTEHFGKSIENDSDEVEERAEN 417
             E+   +     +    +V++   TS     + F   +  D + + ER EN
Sbjct: 2146 LERRQMEISDAMRTLKSEVKDEIRTSLKNLNQ-FLPELPADLEAILERNEN 2195



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 63/280 (22%), Positives = 115/280 (41%), Gaps = 44/280 (15%)

Query: 19  QYEQDISTKEEMIQR----INKCCEDIKENKVTICRIHETINATDEEIDHYCKHSEEIKD 74
           + + D++TK E++++    + + C+   E +  +      I+A  E +++Y     EI D
Sbjct: 323 ELKSDLNTKNELLKQKTIELTRACQKQYELEQELA--FYKIDAKFEPLNYYPSEYAEI-D 379

Query: 75  NCRNWKPTCDVFRKH------EDYMQDQFTVYQ-GTVEKDKEMYHDYICQYKEVLKQYQL 127
              +  P     R        E Y+ D     Q   +E D+++ +D++          QL
Sbjct: 380 KAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQL 439

Query: 128 KYSETPFSREYYEKKREHEEIQS---RVLACTEQLK-MNETIFMKFRVPAPFPSLTKWT- 182
           +  E   S         H+EI+    ++L  TE+ K + E I +K    A    L K   
Sbjct: 440 EDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLS 499

Query: 183 --LNIVN-LRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKA---- 235
             L +VN LR E  D+        +  +  +KE+ +++I I+ L+ +  +H+  KA    
Sbjct: 500 GRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSG 559

Query: 236 ------------------LSETLEEKNKNTENRKELKERI 257
                             L E L    K TE  K+L+E++
Sbjct: 560 KEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQL 599



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 79/354 (22%), Positives = 145/354 (40%), Gaps = 33/354 (9%)

Query: 25   STKEEMIQRINKCCEDIKENKVTICRIHETINATDEEIDHYCKHSEEIKDNCRNWKPTCD 84
            S  EE+  +  +    I E K  +  I + I   +E +    +   + K   +N      
Sbjct: 1647 SLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQ 1706

Query: 85   VFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQLKYSETPFSREYYEK-KR 143
            +       ++ Q       +EK +    +   + + + +  Q +  E  + ++  E+ KR
Sbjct: 1707 LENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKR 1766

Query: 144  EHEEI--QSRVL-ACTEQL-KMNETIFMKFRVPAPFPSLTKWTLNIVNLRCETQDILKHA 199
            E E +  +SR L +C E L K  E +  K  +     + TK  L       + +      
Sbjct: 1767 EIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ----- 1821

Query: 200  SNLTKSSSELKKEVDEMEIEINYLNQ-QISRHNETKALSETLEEKNKNTENRKELKERIF 258
            SNL K    L+  V +++ E++ LN+ ++S HN+  A+ + L+EK    E    L+E + 
Sbjct: 1822 SNLEK----LELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKR---EAVNSLQEELA 1874

Query: 259  GKDEHV----LTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADIKEESSAKQSKLANI 314
               +H+      L  T   Q  L  E  +L + I   ++  R  D ++E   KQ +L  +
Sbjct: 1875 NVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWAN--RFEDCQKEEETKQQQLQVL 1932

Query: 315  DFRQKENDTQI------FNDSAVDNHSKCSHITTITSSQKFMQVRL---LTPQK 359
                +EN  ++      F     +  S+ S + T   + K  Q +L   LT QK
Sbjct: 1933 QNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQK 1986



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 90/423 (21%), Positives = 159/423 (37%), Gaps = 79/423 (18%)

Query: 8   SLDRLLLEFVFQYEQDISTKEEMIQRINKCCEDIKENKVTICRIHETINATDEEIDHYCK 67
           + +R  LE V + E+D+  K  MI+      E++K  +              EEI +  K
Sbjct: 263 AFERFSLEEVERLERDLEKK--MIET-----EELKSKQTRFL----------EEIKNQDK 305

Query: 68  HSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDY-----ICQYK--- 119
            ++ +K+     K +C+  +   D       + Q T+E  +     Y     +  YK   
Sbjct: 306 LNKSLKEEAMLQKQSCEELKS--DLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDA 363

Query: 120 --EVLKQYQLKYSE---TPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAP 174
             E L  Y  +Y+E    P    Y  K R       R +  TE   ++    ++ +   P
Sbjct: 364 KFEPLNYYPSEYAEIDKAPDESPYIGKSR-----YKRNMFATESYIIDSAQAVQIKKMEP 418

Query: 175 FPSLTKWTLNI---VNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHN 231
              L    +N+     L  + +D  K  S      SEL  E+++ E       QQI R  
Sbjct: 419 DEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAE-------QQILRAT 471

Query: 232 ET-KALSETLEEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKM 290
           E  K L E ++ K  +   +  L +++ G+   +  +NK +   L L  + +K       
Sbjct: 472 EEFKQLEEAIQLKKISEAGKDLLYKQLSGR---LQLVNKLRQEALDLELQMEKQ------ 522

Query: 291 HSSEPRVADIKEESSAKQSKLANIDFRQKENDTQIFNDSAVDNHSKCSHITTITSSQKFM 350
                     K+E + KQ ++          D QI  DS      K SH+     S K  
Sbjct: 523 ----------KQEIAGKQKEI---------KDLQIAIDSLDSKDPKHSHMKA-QKSGKEQ 562

Query: 351 QVRLLTPQKQSNSNQWSEKGDKDAEYGDKGTVRQVRESKCTSQAIYTEHFGKSIENDSDE 410
           Q+ ++  Q Q   ++  E   + A+  ++  ++ + E     Q    E   K +E     
Sbjct: 563 QLDIMNKQYQQLESRLDEILSRIAKETEE--IKDLEEQLTEGQIAANEALKKDLEGVISG 620

Query: 411 VEE 413
           ++E
Sbjct: 621 LQE 623



 Score = 34.3 bits (77), Expect = 0.33
 Identities = 35/157 (22%), Positives = 72/157 (45%), Gaps = 26/157 (16%)

Query: 196  LKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALS-----ETLEEKN------ 244
            L+   N  K   E +  + +ME EI+YL + +    E + L+     E  EEK       
Sbjct: 894  LEARMNFDKRQHEAR--IQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQL 951

Query: 245  KNTENRKEL-----KERIFGKDEH-------VLTLNKTQSSQLFLPYESQKLVRPIKMHS 292
            +  E +K+L     +E++FG D+        V T +K  +++L +  +  K +    M  
Sbjct: 952  RELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKI 1011

Query: 293  SEPRVADIKE-ESSAKQSKLANIDFRQKENDTQIFND 328
            ++ R  +++E E  ++++  A  D  + E + ++  +
Sbjct: 1012 NQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQN 1048


>gi|51972208 leucine, glutamate and lysine rich 1 [Homo sapiens]
          Length = 388

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 64/284 (22%), Positives = 120/284 (42%), Gaps = 41/284 (14%)

Query: 27  KEEMIQRINKCCEDIKENKVTICRIHETINATDEE-----IDHYCKHSEEIKDNCR---- 77
           +E++ +RIN    +++  K  + +  E +     E     I H  K  E++++  R    
Sbjct: 31  EEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQ-KSIEQLQETLRQKLL 89

Query: 78  ---NWKPTCDVF-----RKHEDYMQDQFTVYQGT----VEKDKEMYHDYICQYKEVLKQY 125
              NWK   +        +H    ++Q  +++      ++ +KE + D I +YK+  ++ 
Sbjct: 90  SDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEEL 149

Query: 126 QLKYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKWTLNI 185
           Q+K S+               +++  V    E+L  + T     R      S  K   N+
Sbjct: 150 QMKISDLITGAT--------RDLRQEVTTLKEKLHKSHT-----RYTEESNSKEKEIENL 196

Query: 186 VNLRCETQDILKHASNLTKSSSE-LKKEVDEMEIEINYL----NQQISRHNETKALSETL 240
            NL  E +  LK   +   S SE L+KE+++   E+  +     Q I + N+++  +  L
Sbjct: 197 KNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFL 256

Query: 241 EEK-NKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQK 283
           +E   +  E R EL E +    E +L L+K + S  F P    K
Sbjct: 257 QETVRRECEERFELTEALSQAREQLLELSKLRGSLPFSPCSLSK 300


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 60/256 (23%), Positives = 115/256 (44%), Gaps = 55/256 (21%)

Query: 103  TVEKDKEMYHDYICQYKEVLKQYQLKYSETPFSREYYEKK-----REHEEIQSRVLACTE 157
            + E +KEM        KE  ++ + + +++   R+  E+K     +E  ++Q +V A +E
Sbjct: 843  SAETEKEM-----ATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESE 897

Query: 158  QL-----KMNETIFMKFRVPAPFPSLTKWTLNIVNLRCETQDILKHASNLTKSSSELKKE 212
             L     + ++ I  KF++ A    +T+   +   +  E   +      L    SELKK+
Sbjct: 898  NLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAE---LTAKKRKLEDECSELKKD 954

Query: 213  VDEMEIEINYL-NQQISRHNETKALSETL----EEKNKNTENRKELKER-------IFGK 260
            +D++E+ +  +  ++ +  N+ K L+E L    E   K T  +K L+E        +  +
Sbjct: 955  IDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE 1014

Query: 261  DEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADIKEESSAKQSKLANIDF---- 316
            ++ V +LNKT+S                     E +V D+  ESS +Q K   +D     
Sbjct: 1015 EDKVNSLNKTKS-------------------KLEQQVEDL--ESSLEQEKKLRVDLERNK 1053

Query: 317  RQKENDTQIFNDSAVD 332
            R+ E D ++  +S +D
Sbjct: 1054 RKLEGDLKLAQESILD 1069



 Score = 37.7 bits (86), Expect = 0.030
 Identities = 72/393 (18%), Positives = 151/393 (38%), Gaps = 63/393 (16%)

Query: 23   DISTKEEMIQRINKC-------CEDIKENKVTICRIHETINATDEEIDHYCKHSEEIKDN 75
            D+  +E+ +  +NK         ED++ +     ++   +     +++   K ++E   +
Sbjct: 1010 DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILD 1069

Query: 76   CRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQLKYSE---- 131
              N K   D   K +D+   ++   Q  VE ++ +      Q+++ +K+ Q +  E    
Sbjct: 1070 LENDKQQLDERLKKKDF---EYCQLQSKVEDEQTLG----LQFQKKIKELQARIEELEEE 1122

Query: 132  ---------------TPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFP 176
                           + ++RE  E     EE         E  K  E  F+K R      
Sbjct: 1123 IEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEA 1182

Query: 177  SLTKWTLNIVNLRCETQDIL----KHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNE 232
            +L    + +  LR +  D +    +   NL +   +L+KE  E ++EI+ L+  +   ++
Sbjct: 1183 TLQHEAM-VAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSK 1241

Query: 233  TKA----LSETLEE-----KNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQK 283
            +KA    +  TLE+     + KN E ++ L E         LT  K++     L  E+ +
Sbjct: 1242 SKANLEKICRTLEDQLSEARGKNEEIQRSLSE---------LTTQKSR-----LQTEAGE 1287

Query: 284  LVRPIKMHSSEPRVADIKEESSAKQSKLANIDFRQKENDTQIFNDSAVDNHSKCSHITTI 343
            L R ++   S        +++  +Q++       ++         +   +   C  +   
Sbjct: 1288 LSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQ 1347

Query: 344  TSSQKFMQVRLLTPQKQSNSN--QWSEKGDKDA 374
               ++  +  L     ++NS   QW  K + DA
Sbjct: 1348 YEEEQEGKAELQRALSKANSEVAQWRTKYETDA 1380


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 70/364 (19%), Positives = 152/364 (41%), Gaps = 49/364 (13%)

Query: 13   LLEFVFQYEQDISTKE--EMIQRINKCCEDIKENKVTIC--------RIHETINATDEEI 62
            L E   +  +D   K+   ++Q + +    I E K  +          + + I    EE 
Sbjct: 763  LKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEES 822

Query: 63   DHYCKHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVL 122
               C   EE+K   R+++    + RK  + +Q +    Q  + + K        + + +L
Sbjct: 823  VVQC---EELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLL 879

Query: 123  KQYQLKYSETPFSREYYEKK-----REHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPS 177
             Q + + S+T    E + +K     +EHE ++  +     + +  E I +K  + A  PS
Sbjct: 880  IQVE-EVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSL-AKSPS 937

Query: 178  LTKWTLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQI-SRHNETKAL 236
            +    L+ V      +++ +   NL K   E +++++++++      +++ S   ET+ +
Sbjct: 938  VKNDPLSSV------KELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTV 991

Query: 237  SETLEE-KNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEP 295
             E LE  +++  +    +++ I G + +           L L YE Q     ++      
Sbjct: 992  KEELESLRSEKDQLSASMRDLIQGAESY---------KNLLLEYEKQSEQLDVE------ 1036

Query: 296  RVADIKEESSAKQSKLANIDFRQKENDTQIFNDSAVDNHSKCSHITTITSSQKFMQVRLL 355
                 KE ++  + ++ ++  RQ  N T        DN    + I T+ S+ K ++V++L
Sbjct: 1037 -----KERANNFEHRIEDLT-RQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQIL 1090

Query: 356  TPQK 359
              Q+
Sbjct: 1091 EVQR 1094



 Score = 33.9 bits (76), Expect = 0.43
 Identities = 29/109 (26%), Positives = 57/109 (52%), Gaps = 8/109 (7%)

Query: 208 ELKKEVDEMEIEINYLNQQISRHNE-TKALSETLEEKNKNTENRKEL--KERIFGKDEHV 264
           EL K+V++    I Y ++   + NE T  L ETL+EK++N +  ++L  + ++  +D+ V
Sbjct: 626 ELGKKVEQT---IQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEV 682

Query: 265 LT--LNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADIKEESSAKQSKL 311
           L+  +         L  E ++L R +++  S+     +KE  +  + KL
Sbjct: 683 LSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKL 731


>gi|225579095 S-phase cyclin A-associated protein in the ER isoform
           b [Homo sapiens]
          Length = 1154

 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 49/204 (24%), Positives = 85/204 (41%), Gaps = 19/204 (9%)

Query: 128 KYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKWTLNIVN 187
           K S     R   E K++HEE Q +     E+L+  +T+ ++ ++      + KW   +++
Sbjct: 284 KLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQ-KLLEREKDVRKWKEELLD 342

Query: 188 LRCET-QDILKHAS--------NLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSE 238
            R    ++ L HA          + K + E + +V+E+   IN L  Q  RH+    L E
Sbjct: 343 QRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAF-INTLEAQNKRHDVLSKLKE 401

Query: 239 TLEEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPI--KMHSSEPR 296
             +  N+  E R+  +E    +DE V      Q  +  L  E Q  V  +  K    E R
Sbjct: 402 YEQRLNELQEERQRRQEEKQARDEAV------QERKRALEAERQARVEELLMKRKEQEAR 455

Query: 297 VADIKEESSAKQSKLANIDFRQKE 320
           +   ++E    +   A    R +E
Sbjct: 456 IEQQRQEKEKAREDAARERARDRE 479



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 49/206 (23%), Positives = 93/206 (45%), Gaps = 26/206 (12%)

Query: 119 KEVLKQYQLKYSET--PFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFP 176
           +E+ K+ QLK+ E+      +  ++K +  E+ S   A T+              P   P
Sbjct: 494 EELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDY------------APKLTP 541

Query: 177 SLTKWTLNIVNLRCETQDIL-------KHASNLTKSSSELKKEVDEMEIEINYLNQQI-S 228
              K   ++ N+   ++  L       KH   + +++S   +E+ + E+E   L + I  
Sbjct: 542 YERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIID 601

Query: 229 RHNETKALSETL---EEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLV 285
              E+ A +E L   EE+ KN +  K++K R+  + +   +L +T++S    PY++ KL 
Sbjct: 602 IVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKA-KLQ 660

Query: 286 RPIKMHSSEPRVADIKEESSAKQSKL 311
           R  K    + +V D    ++ K S L
Sbjct: 661 RLAKDLLKQVQVQDSGSWANNKVSAL 686


>gi|225579092 S-phase cyclin A-associated protein in the ER isoform
           a [Homo sapiens]
          Length = 1400

 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 49/204 (24%), Positives = 85/204 (41%), Gaps = 19/204 (9%)

Query: 128 KYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKWTLNIVN 187
           K S     R   E K++HEE Q +     E+L+  +T+ ++ ++      + KW   +++
Sbjct: 530 KLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQ-KLLEREKDVRKWKEELLD 588

Query: 188 LRCET-QDILKHAS--------NLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSE 238
            R    ++ L HA          + K + E + +V+E+   IN L  Q  RH+    L E
Sbjct: 589 QRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAF-INTLEAQNKRHDVLSKLKE 647

Query: 239 TLEEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPI--KMHSSEPR 296
             +  N+  E R+  +E    +DE V      Q  +  L  E Q  V  +  K    E R
Sbjct: 648 YEQRLNELQEERQRRQEEKQARDEAV------QERKRALEAERQARVEELLMKRKEQEAR 701

Query: 297 VADIKEESSAKQSKLANIDFRQKE 320
           +   ++E    +   A    R +E
Sbjct: 702 IEQQRQEKEKAREDAARERARDRE 725



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 49/206 (23%), Positives = 93/206 (45%), Gaps = 26/206 (12%)

Query: 119 KEVLKQYQLKYSET--PFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFP 176
           +E+ K+ QLK+ E+      +  ++K +  E+ S   A T+              P   P
Sbjct: 740 EELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDY------------APKLTP 787

Query: 177 SLTKWTLNIVNLRCETQDIL-------KHASNLTKSSSELKKEVDEMEIEINYLNQQI-S 228
              K   ++ N+   ++  L       KH   + +++S   +E+ + E+E   L + I  
Sbjct: 788 YERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIID 847

Query: 229 RHNETKALSETL---EEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLV 285
              E+ A +E L   EE+ KN +  K++K R+  + +   +L +T++S    PY++ KL 
Sbjct: 848 IVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKA-KLQ 906

Query: 286 RPIKMHSSEPRVADIKEESSAKQSKL 311
           R  K    + +V D    ++ K S L
Sbjct: 907 RLAKDLLKQVQVQDSGSWANNKVSAL 932


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
           sapiens]
          Length = 1843

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 51/256 (19%), Positives = 100/256 (39%), Gaps = 24/256 (9%)

Query: 10  DRLLLEFVFQYEQDISTKEEMIQRINKCCEDIKENKVTICRIHETINATDEEIDHYCKHS 69
           +++L E + +    +S  E   ++I K  E  KE         E     + E+ H  K +
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG-------ERAEELENELHHLEKEN 641

Query: 70  EEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQ-LK 128
           E ++    N K TC+     E    +        +E++       +  +K +  Q + L+
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSE--------LERENRKLKKTLDSFKNLTFQLESLE 693

Query: 129 YSETPFSREYYEKKREHEEIQSRVLACTE-QLKMNETIFMKFRVP-------APFPSLTK 180
              +    E  E +R  E ++   +   + QL+  E    K ++        A F    +
Sbjct: 694 KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER 753

Query: 181 WTLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETL 240
             ++   L  E Q + K   N  K   +L+ E+ ++E+E   L + +     +    E L
Sbjct: 754 LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQL 813

Query: 241 EEKNKNTENRKELKER 256
           E++NK+ E      E+
Sbjct: 814 EKENKSLEQETSQLEK 829



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 53/308 (17%), Positives = 125/308 (40%), Gaps = 19/308 (6%)

Query: 21  EQDISTKEEMIQRINKCCEDIKENKVTICRIHETINATDE-EIDHYCKHSEEIKDNCRNW 79
           E +I  +++ +Q      +D+ + K  + +  ET+    E +I    + +E +     + 
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570

Query: 80  KPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQLKYSETPFSREYY 139
           +    +    E  ++D        +EK+ ++ H+ I +    L + + +  +     E+Y
Sbjct: 571 RQRSQI--SAEARVKD--------IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY 620

Query: 140 EKKREH-EEIQSRVLACTEQLKMNETIFMKFRVPA-PFPSLTKWTLNIVNLRCETQDILK 197
           ++K E  EE+++ +    ++ ++ +      ++      +L +    +     + +  L 
Sbjct: 621 KEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLD 680

Query: 198 HASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETLEEKNKNTENRKE-LKER 256
              NLT     L+KE  +++ E   L + +            L+ +NK  E+ KE LK+ 
Sbjct: 681 SFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKG 740

Query: 257 IFGKDEHVLTLNKTQSSQLFLPYESQKLVRPI-----KMHSSEPRVADIKEESSAKQSKL 311
           +           + + S   L  E+Q+L + +     K+   E  + D++ E+   Q  L
Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL 800

Query: 312 ANIDFRQK 319
             +    K
Sbjct: 801 EELKISSK 808



 Score = 33.1 bits (74), Expect = 0.73
 Identities = 48/285 (16%), Positives = 119/285 (41%), Gaps = 41/285 (14%)

Query: 21   EQDISTKEEMIQRINKCCEDIKENKVTICRIHETINATDEEIDHYCKHSEEIKDNCRNWK 80
            E+ I+  E  ++      + +++   T+ + +E +    +E +   + S  I      W+
Sbjct: 973  EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWE 1031

Query: 81   PTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQLKYSETPFSREYYE 140
                  R+ ++  ++   V    +E ++   +  +   K+ LK  QLK  ET        
Sbjct: 1032 ------RESQETTRELLKVKDRLIEVERN--NATLQAEKQALKT-QLKQLET-------- 1074

Query: 141  KKREHEEIQSRVLACTEQL----KMNETI-FMKFRVPAPFPSLTKWTLNIVN-------- 187
               ++  +Q+++LA   Q     + N T+     ++     +L   + +++N        
Sbjct: 1075 ---QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ 1131

Query: 188  ---LRCETQDILKHASNLTKSSSELKKEVDEMEI----EINYLNQQISRHNETKALSETL 240
               L  E + ++K   +L      L K+ +++E+    + +     IS+H   K+  + L
Sbjct: 1132 QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL 1191

Query: 241  EEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLV 285
            E ++++ E+R     +  G+ E +  + K +  ++ L  ++ + V
Sbjct: 1192 EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETV 1236


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
           sapiens]
          Length = 1870

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 51/256 (19%), Positives = 100/256 (39%), Gaps = 24/256 (9%)

Query: 10  DRLLLEFVFQYEQDISTKEEMIQRINKCCEDIKENKVTICRIHETINATDEEIDHYCKHS 69
           +++L E + +    +S  E   ++I K  E  KE         E     + E+ H  K +
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG-------ERAEELENELHHLEKEN 641

Query: 70  EEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQ-LK 128
           E ++    N K TC+     E    +        +E++       +  +K +  Q + L+
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSE--------LERENRKLKKTLDSFKNLTFQLESLE 693

Query: 129 YSETPFSREYYEKKREHEEIQSRVLACTE-QLKMNETIFMKFRVP-------APFPSLTK 180
              +    E  E +R  E ++   +   + QL+  E    K ++        A F    +
Sbjct: 694 KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER 753

Query: 181 WTLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETL 240
             ++   L  E Q + K   N  K   +L+ E+ ++E+E   L + +     +    E L
Sbjct: 754 LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQL 813

Query: 241 EEKNKNTENRKELKER 256
           E++NK+ E      E+
Sbjct: 814 EKENKSLEQETSQLEK 829



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 53/308 (17%), Positives = 125/308 (40%), Gaps = 19/308 (6%)

Query: 21  EQDISTKEEMIQRINKCCEDIKENKVTICRIHETINATDE-EIDHYCKHSEEIKDNCRNW 79
           E +I  +++ +Q      +D+ + K  + +  ET+    E +I    + +E +     + 
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570

Query: 80  KPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQLKYSETPFSREYY 139
           +    +    E  ++D        +EK+ ++ H+ I +    L + + +  +     E+Y
Sbjct: 571 RQRSQI--SAEARVKD--------IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY 620

Query: 140 EKKREH-EEIQSRVLACTEQLKMNETIFMKFRVPA-PFPSLTKWTLNIVNLRCETQDILK 197
           ++K E  EE+++ +    ++ ++ +      ++      +L +    +     + +  L 
Sbjct: 621 KEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLD 680

Query: 198 HASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETLEEKNKNTENRKE-LKER 256
              NLT     L+KE  +++ E   L + +            L+ +NK  E+ KE LK+ 
Sbjct: 681 SFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKG 740

Query: 257 IFGKDEHVLTLNKTQSSQLFLPYESQKLVRPI-----KMHSSEPRVADIKEESSAKQSKL 311
           +           + + S   L  E+Q+L + +     K+   E  + D++ E+   Q  L
Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL 800

Query: 312 ANIDFRQK 319
             +    K
Sbjct: 801 EELKISSK 808



 Score = 33.1 bits (74), Expect = 0.73
 Identities = 48/285 (16%), Positives = 119/285 (41%), Gaps = 41/285 (14%)

Query: 21   EQDISTKEEMIQRINKCCEDIKENKVTICRIHETINATDEEIDHYCKHSEEIKDNCRNWK 80
            E+ I+  E  ++      + +++   T+ + +E +    +E +   + S  I      W+
Sbjct: 972  EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWE 1030

Query: 81   PTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQLKYSETPFSREYYE 140
                  R+ ++  ++   V    +E ++   +  +   K+ LK  QLK  ET        
Sbjct: 1031 ------RESQETTRELLKVKDRLIEVERN--NATLQAEKQALKT-QLKQLET-------- 1073

Query: 141  KKREHEEIQSRVLACTEQL----KMNETI-FMKFRVPAPFPSLTKWTLNIVN-------- 187
               ++  +Q+++LA   Q     + N T+     ++     +L   + +++N        
Sbjct: 1074 ---QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ 1130

Query: 188  ---LRCETQDILKHASNLTKSSSELKKEVDEMEI----EINYLNQQISRHNETKALSETL 240
               L  E + ++K   +L      L K+ +++E+    + +     IS+H   K+  + L
Sbjct: 1131 QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL 1190

Query: 241  EEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLV 285
            E ++++ E+R     +  G+ E +  + K +  ++ L  ++ + V
Sbjct: 1191 EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETV 1235


>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
          Length = 1946

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 53/281 (18%), Positives = 132/281 (46%), Gaps = 20/281 (7%)

Query: 55   INATDEEIDHYCKHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDY 114
            ++ T E+ D   +   E ++   N +  C+   K +  ++ +       VE+++E+  + 
Sbjct: 890  VSLTQEKNDLILQLQAE-QETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSEL 948

Query: 115  ICQYKEVLKQ-YQLKYSETPFSREYYEKKREHEEIQSRVLACTEQLK-MNETIFMKFRVP 172
              + +++  + ++LK           + ++E    + +V   TE+++ +NE I    R  
Sbjct: 949  TARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAA 1008

Query: 173  APFPSLTKWTLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQ-QISRHN 231
                   + TL+ +++  E        S+L+K++ +L+++VDE+E  +    + +++   
Sbjct: 1009 KVVQEAHQQTLDDLHMEEEK------LSSLSKANLKLEQQVDELEGALEQERKARMNCER 1062

Query: 232  ETKALSETLEEKNKNTEN----RKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRP 287
            E   L   L+   ++ EN    ++ L E +  K+  +  +N    ++  L  + QK V+ 
Sbjct: 1063 ELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKE 1122

Query: 288  IKMHSSEPRVADIKEESSAKQSKLANIDFRQKENDTQIFND 328
            +     + ++ D+KE+  A+++  A ++ R++ + TQ   D
Sbjct: 1123 L-----QTQIKDLKEKLEAERTTRAKME-RERADLTQDLAD 1157



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 63/352 (17%), Positives = 139/352 (39%), Gaps = 43/352 (12%)

Query: 142  KREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKWTLNIVNLRCETQDILKHASN 201
            K++HEE Q+ + A  ++++   T  +K +      +  +  +    LR E +++ +  SN
Sbjct: 1469 KQKHEESQALLDASQKEVQALSTELLKLK-----NTYEESIVGQETLRRENKNLQEEISN 1523

Query: 202  LTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETLEEKNKN---------TENRKE 252
            LT    E  K + EME     + ++ +    T   +E   E+N++          E + E
Sbjct: 1524 LTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAE 1583

Query: 253  LKERIFGKDEHVLTLNKTQ-----SSQLFLPYESQKLVRPIK--------MHSSEPRVAD 299
            L+ ++  KDE +    + Q     S Q  L  E++  +   +        ++  E +++ 
Sbjct: 1584 LERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSC 1643

Query: 300  IKEESSAKQSKLANIDFRQKENDTQIFNDSAVDNHSKCSHITTITSSQKFMQVRLLTPQK 359
               + S     L  +  + K+   Q+ +DS   N      +         +Q  L   + 
Sbjct: 1644 ANRQVSEATKSLGQLQIQIKDLQMQL-DDSTQLNSDLKEQVAVAERRNSLLQSEL---ED 1699

Query: 360  QSNSNQWSEKGDKDAEYGDKGTVRQVRESKCTSQAIYTEHFG-----KSIENDSDEVEER 414
              +  + +E+G + +E        ++ E+       YT++       K +E D   +++ 
Sbjct: 1700 LRSLQEQTERGRRLSE-------EELLEATERINLFYTQNTSLLSQKKKLEADVARMQKE 1752

Query: 415  AENFPRTSEIPIFLGTPKAVKAPESLEKIKFPKTPPFEINRNRNAVPEVQTE 466
            AE   +  +         A++A    E++K  +     + R R  + +  T+
Sbjct: 1753 AEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITD 1804


>gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]
          Length = 1219

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 93/450 (20%), Positives = 184/450 (40%), Gaps = 56/450 (12%)

Query: 31  IQRINKCCEDIKENKVTICRIHETINATDEEIDHYCKHSEEIKDNCRNWKPTCDVFRKHE 90
           IQRI      I+EN+     I E  N  +E+ D   K SE I+ N R  + +  +  K  
Sbjct: 567 IQRI------IQENERLKQEILEKSNRIEEQND---KISELIERNQRYVEQSNLMMEKRN 617

Query: 91  DYMQDQFTVYQGTV---EKDKEMYHDYICQYKEVLKQYQLKYS-----ETPFSREYYEKK 142
           + +Q      Q  V   E++K    + +      +   QLK +     ET    +  E  
Sbjct: 618 NSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESL 677

Query: 143 REHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPS----LTKWTLNIVNLRCETQDILKH 198
           +E + ++ ++     Q K++E      +  + F S      +  L + +L  E  D+   
Sbjct: 678 KETDLLRGQLTKV--QAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVE 735

Query: 199 ASNLTKSSSELKK----EVDEMEIEINYLNQQISRHNETKALSETLEEKNKNTEN----- 249
             +L K+ SE KK    E  + E EI+ + +  S   E   L + L++   +T+      
Sbjct: 736 KESLEKNLSERKKKSAQERSQAEEEIDEIRK--SYQEELDKLRQLLKKTRVSTDQAAAEQ 793

Query: 250 ----RKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADIKEESS 305
               + EL+ +   K EH+L   K +  Q +    +Q+        + + ++  ++E+  
Sbjct: 794 LSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQR-------DAYQQKLVQLQEKCL 846

Query: 306 AKQSKLANIDFRQKENDTQIFNDSAVDNHSKCSHITTITSSQKFMQVRLLTPQKQSNSNQ 365
           A Q+++  +    K+N+  I       N S+ S +    S       +++    QS   +
Sbjct: 847 ALQAQITALT---KQNEQHI--KELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRRE 901

Query: 366 WSEKGDKDAEYGDKGTVRQVRES-KCTSQAIYTEHFGKSIENDSDEVEERAENFP-RTSE 423
           +    + +  Y  +  +  +  + K  +  +  +   +  E+ S+E EE+AE  P R S+
Sbjct: 902 F----ELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQ 957

Query: 424 IPIFLGTPKAVKAPESLEKIKFPKTPPFEI 453
                 +    +AP + E+ + P  P  ++
Sbjct: 958 EQSASASSGQPQAPLNRERPESPMVPSEQV 987


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 54/279 (19%), Positives = 110/279 (39%), Gaps = 49/279 (17%)

Query: 21   EQDISTKEEMIQRINKCCEDIKENK------------------VTICRIHETINATDEEI 62
            EQD + KE+ +Q   K  +DI++ K                     CR  + I   +EE+
Sbjct: 1088 EQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEEL 1147

Query: 63   DHYCKHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVL 122
                 H  E      N K    +  + +  +Q +    +  VE++K        + +++L
Sbjct: 1148 K---SHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEK--------RNQQIL 1196

Query: 123  KQYQLKYSETPFSREYYEKKRE-HEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKW 181
            K  Q+K  E    +E+ EK+ + H EI+ + +   +  +    + M+         +T  
Sbjct: 1197 KD-QVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQ---------ITAL 1246

Query: 182  TLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEIN--------YLNQQISRHNET 233
              N+  ++ E Q   +  S L K + +L+ E+  +E  +          L + +    E 
Sbjct: 1247 NENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEI 1306

Query: 234  KALSETLEEKNKNTENRKELKERIFGKDEHVLTLNKTQS 272
            + L   + E  +  +N     + + G++   L +  TQ+
Sbjct: 1307 EKLQTKVLELQRKLDNTTAAVQEL-GRENQSLQIKHTQA 1344



 Score = 30.4 bits (67), Expect = 4.7
 Identities = 47/271 (17%), Positives = 103/271 (38%), Gaps = 36/271 (13%)

Query: 119 KEVLKQYQLKYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSL 178
           KE L + + KY       +  +++RE +E     L        ++ +  + ++      L
Sbjct: 378 KEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRL 437

Query: 179 TKWT-LNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALS 237
            +   L+   L  + Q +      L++   +LK++V       + L++   +H E +AL 
Sbjct: 438 KEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQ 497

Query: 238 ETLEEKNKNTENRKELKERIFG-KDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPR 296
           ++   K +  +N  E   R  G KD+ +  L                      +  S+  
Sbjct: 498 QSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEAL-------------------LQKSKEN 538

Query: 297 VADIKEESSAKQSKLANIDFRQKENDTQIFNDSAVDNHSKCSHITTITSSQKFMQVRLLT 356
           ++ +++E     +K+     +  E +T + N     NH+    +T +T   K        
Sbjct: 539 ISLLEKEREDLYAKI-----QAGEGETAVLNQLQEKNHTLQEQVTQLTEKLK-------- 585

Query: 357 PQKQSNSNQWSEKGDKDAEYGDKGTVRQVRE 387
              QS S++ +++   D     K  +R  ++
Sbjct: 586 --NQSESHKQAQENLHDQVQEQKAHLRAAQD 614



 Score = 29.6 bits (65), Expect = 8.1
 Identities = 30/139 (21%), Positives = 64/139 (46%), Gaps = 20/139 (14%)

Query: 184 NIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHN--------ETKA 235
           ++  LR E QD+          S ELKKE+++ +     L QQ ++ +        E ++
Sbjct: 84  DVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQ----GLQQQEAKPDGLVTDSSAELQS 139

Query: 236 LSETLEEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEP 295
           L + LEE      N K++K+    K   +     T+ + +   Y+ ++ +R     ++E 
Sbjct: 140 LEQQLEEAQTENFNIKQMKDLFEQKAAQL----ATEIADIKSKYDEERSLR----EAAEQ 191

Query: 296 RVADIKEESSAKQSKLANI 314
           +V  + EE + + + + ++
Sbjct: 192 KVTRLTEELNKEATVIQDL 210


>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
          Length = 1094

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 110/559 (19%), Positives = 209/559 (37%), Gaps = 103/559 (18%)

Query: 23  DISTKEEMIQRINKCCEDIKENKVTICRIHETINATDEEIDHYCKHSEEIKDNCR---NW 79
           + S     ++ + +C E   + K  +    E +     E+++  K   ++ D  +   N 
Sbjct: 373 NFSAMASELEEVKRCMERKDKEKAHLASQVENLT---RELENGEKQQLQMLDRLKEIQNH 429

Query: 80  KPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQLKYSETPFSREYY 139
             TC+  RKH D    + T +     K  E Y   + Q  E LK             E  
Sbjct: 430 FDTCEAERKHADLQISELTRHAEDATKQAERYLSEL-QQSEALK-------------EEA 475

Query: 140 EKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKWTLNIVNLRCETQDILKHA 199
           EK+RE  +++++                         S+ +W L    L    +   +  
Sbjct: 476 EKRREDLKLKAQ------------------------ESIRQWKLKHKKLERALEKQSETV 511

Query: 200 SNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETLEEKNKNTE--NRKELKERI 257
             LT  ++++ KE DE++ ++    QQI   N  K L++ L ++    E  + KE K R 
Sbjct: 512 DELTGKNNQILKEKDELKTQLYAALQQI--ENLRKELNDVLTKRALQEEELHSKEEKLRD 569

Query: 258 FGKDEHVLTLNKTQSSQLFLPYESQ-----KLVRPIKMHSS--EPRVADIKEESSAKQSK 310
               +  L L    S       ES+     K+   +K+  +  E  +A++K+  +  ++K
Sbjct: 570 IKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAK 629

Query: 311 LANIDFRQKEND---TQIFNDSAVDNHSKCSHITTITSSQKFMQVRLLTPQKQSNSNQWS 367
           L  +    K+       + N  A +  +K + +  ++          LT Q +S   + +
Sbjct: 630 LLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSD---------LTAQAKSRDEETA 680

Query: 368 E-----KGDKDAEYGDKGTVRQVRESKCTSQAIYTEHFGKSIENDSDEVEERAENFPR-T 421
                 K ++D         R++++   + Q++ T+H           ++E  ++F +  
Sbjct: 681 TIITQLKLERDVHQ------RELKDLTSSLQSVKTKH--------EQNIQELMKHFKKEK 726

Query: 422 SEIPIFLGTPKAVKAPESLEKIKFPKTPPFEINRNR---NAVPEVQTEKESPGLSFLMSY 478
           SE    + T KA    ESLE+    K    ++ + +   + + E  T+ E+      + Y
Sbjct: 727 SEAENHIRTLKA----ESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKY 782

Query: 479 TSRSPGLNLFDSSVFDTEISSDQFNEHYSAR-----NLNPLSSEQE-IGNLLEKPEGEDG 532
                 L   +  +    I  +       AR      L  L +EQE I  ++ K      
Sbjct: 783 QCLKDQLEEREKHI---SIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAAC 839

Query: 533 FTFSFPSDTSTHTFGAGKD 551
            TFS  S      F +G D
Sbjct: 840 KTFSKDSVEKLKVFSSGPD 858


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 69/311 (22%), Positives = 138/311 (44%), Gaps = 42/311 (13%)

Query: 75   NCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQLKYSETPF 134
            N ++W P  ++F K +  ++        + E +KEM        KE  ++ + + + +  
Sbjct: 827  NVKHW-PWMNLFFKIKPLLK--------SAEAEKEM-----ATMKEDFERTKEELARSEA 872

Query: 135  SREYYEKK-----REHEEIQSRVLACTEQLKMNET-----IFMKFRVPAPFPSLTKWTLN 184
             R+  E+K     +E  ++Q +V + TE L   E      I  K  + A    LT+    
Sbjct: 873  RRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEE 932

Query: 185  IVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYL-NQQISRHNETKALSETLEEK 243
               +  E   ++    NL    S LK+++D++E+ +  +  ++ +  N+ K LSE +   
Sbjct: 933  EEEMNSE---LVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTAL 989

Query: 244  NKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADIKEE 303
             +N    K  KE+   ++ H  TL+  Q        E  K+   IK+++   +  D  E 
Sbjct: 990  EENIS--KLTKEKKSLQEAHQQTLDDLQ-------VEEDKVNGLIKINAKLEQQTDDLEG 1040

Query: 304  SSAKQSKL-ANID--FRQKENDTQIFNDSAVDNHSKCSHITTITSSQKF--MQVRLLTPQ 358
            S  ++ KL A+++   R+ E D ++  +S +D  +    I      ++F   Q++     
Sbjct: 1041 SLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDD 1100

Query: 359  KQSNSNQWSEK 369
            +Q +S Q+ +K
Sbjct: 1101 EQVHSLQFQKK 1111



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 67/319 (21%), Positives = 125/319 (39%), Gaps = 51/319 (15%)

Query: 90   EDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQLKYSE------------TPFSRE 137
            E   + +F + Q   + D E  H    Q+++ +K+ Q +  E                ++
Sbjct: 1082 EKLKKKEFELSQLQAKIDDEQVHSL--QFQKKIKELQARIEELEEEIEAEHTLRAKIEKQ 1139

Query: 138  YYEKKREHEEIQSRVL----ACTEQLKMN---ETIFMKFRVPAPFPSL----TKWTL--- 183
              +  RE EEI  R+     A + Q++MN   E  F K R      +L    T  TL   
Sbjct: 1140 RSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1199

Query: 184  ---NIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETL 240
               ++  L  +  ++ +    L K  SELK E+D+M   I  L++  S    T     T+
Sbjct: 1200 QADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERT---CRTV 1256

Query: 241  EEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADI 300
            E++    + + E + ++     H L + K +        ++Q      ++   E  ++ +
Sbjct: 1257 EDQFSEIKAKDEQQTQLI----HDLNMQKAR-------LQTQNGELSHRVEEKESLISQL 1305

Query: 301  KEESSAKQSKLANIDFRQKENDTQIFNDSA---VDNHSKCSHITTITSSQKFMQVRLLTP 357
             +   A   +L  +  RQ E +T+  N  A     +   C  +      ++  +  L   
Sbjct: 1306 TKSKQALTQQLEELK-RQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRA 1364

Query: 358  QKQSNSN--QWSEKGDKDA 374
              ++NS   QW  K + DA
Sbjct: 1365 LSKANSEVAQWRTKYETDA 1383


>gi|14165274 golgi-associated microtubule-binding protein HOOK3
           [Homo sapiens]
          Length = 718

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 103/511 (20%), Positives = 200/511 (39%), Gaps = 89/511 (17%)

Query: 2   NDSLFVSLDRLLLEFVFQYEQDISTKEEMIQRINKCCEDI-----------KENKVTICR 50
           ND+ +V LDR L +   +  + +S KEE+ QR ++    +            EN+V + R
Sbjct: 168 NDA-YVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMER 226

Query: 51  IHETINATD----------------EEIDHYCKHSEEIKDNCRNWKPTCDVFRKHEDYMQ 94
           ++++ +  D                E++       E  KD   +++  C+   K    ++
Sbjct: 227 LNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKD---DYRIRCEELEKEISELR 283

Query: 95  DQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQLKYSETPFSREYYEKKRE---HEEIQSR 151
            Q      T+  + +   D I    +VL+    K S+     E Y+KK E       Q +
Sbjct: 284 QQNDELT-TLADEAQSLKDEI----DVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVK 338

Query: 152 VLACTEQLKMNETIFMK---FRVPAPFPSLTKWTLNIVNLRCETQDILKHASNLTKSSSE 208
           +L     + M  T+ ++    +  A    L  +   +V L+    +  K A  L      
Sbjct: 339 LLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKR 398

Query: 209 LKKEVDEMEIEINYLNQQISRHNETKALSETLEEKNKNTENRKELKERIFGKDEHVLTLN 268
           LK++VD ++ E + L        E  +L ET+EE         +L        + ++ L 
Sbjct: 399 LKEKVDSLQKEKDRL------RTERDSLKETIEELRCVQAQEGQL------TTQGLMPLG 446

Query: 269 KTQSS-----QLFLPYESQKLVR---PIKMHSSEPRVADIKEESSAKQSKLANIDFRQKE 320
             +SS     ++  P   +KL+R     KM       +D  E+ +  QS L + + R+ E
Sbjct: 447 SQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSD-NEKIALLQSLLDDANLRKNE 505

Query: 321 NDTQ--IFNDSAVDNHSKCSHITTITSSQ--KFMQVRLLTPQKQSNSNQWSEKGDKDAEY 376
            +T+  + N   ++  S+   +      Q  K     LL  + + +  +  E  +   E 
Sbjct: 506 LETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANN---EL 562

Query: 377 GDKGTVRQVRESKCTSQAIYTEHFGKSIENDSDEVEERAENFPRTSEIPIFLGTPKAVKA 436
             K  + +  E +  + ++  E   +++    +E+++  E + +  E        KA   
Sbjct: 563 QKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLE--------KAKSV 614

Query: 437 PESLEKIKFPKTPPFEINRNRNAVPEVQTEK 467
             +L+    PK       +N+ A PE+Q  K
Sbjct: 615 IRTLD----PK-------QNQGAAPEIQALK 634


>gi|33946313 ninein isoform 4 [Homo sapiens]
          Length = 2096

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 61/308 (19%), Positives = 127/308 (41%), Gaps = 55/308 (17%)

Query: 59  DEEIDHYCKHSEEIKDNCRNWKPTCDVFRKHEDY--------MQDQFTVYQGTVEKDKEM 110
           ++++ HY K  +E   +C+  +       ++E +        ++++    QG     KE 
Sbjct: 636 EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 695

Query: 111 YHDYICQYKEVLKQYQLKYSETPFSREYYEKKREHEEIQSRVLAC-----TEQLKMNETI 165
           +H+  C+++E  KQ Q+K  E     +   + +   E+++R+         E+  +  + 
Sbjct: 696 HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 755

Query: 166 FMKFRVPAPFPSLTKW-----TLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEI 220
           + + +V      L ++     T  +     E +++ K    L K   EL++  ++ME E 
Sbjct: 756 WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKEL--LEKHQRELQEGREKMETEC 813

Query: 221 NYLNQQISR--HNETKALSETLEEKNKNTENR-----KELKER--------IFGKDEHVL 265
           N    QI     ++ + ++E  E   ++ E R     K+L+E+         F KDE   
Sbjct: 814 NRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQ 873

Query: 266 -----------TLNKTQSSQLFLPYESQKLVRPIKMHSSEPRV---------ADIKEESS 305
                      TL + +++ L L  E + L +  K H +   V          D++  S 
Sbjct: 874 ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933

Query: 306 AKQSKLAN 313
            +QS L++
Sbjct: 934 TQQSLLSD 941



 Score = 36.6 bits (83), Expect = 0.066
 Identities = 66/320 (20%), Positives = 118/320 (36%), Gaps = 68/320 (21%)

Query: 67   KHSEEIKDNCRNWKPTCDVFRKHEDYMQDQF----TVYQGTVEKDKEMYHDYICQYKEVL 122
            K  E I +    +K   +   +  D +Q++     T Y   +E +KE+  +      E+ 
Sbjct: 1242 KMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELK 1301

Query: 123  KQYQLKYSETPFSREYYEKKREHEEIQSRVLACTEQL-KMNETIFMKFRVPAPFPSLTKW 181
            K  ++  +     + Y E K E+EE+   VL    ++ K+ E++  +        SL   
Sbjct: 1302 KMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENL 1361

Query: 182  TL----NIVNLRCETQDILKHASNLTKSSSELKKEVDEME-----------IEINYLNQQ 226
             +    NI+ L    ++ +    ++     E K+E   +E            EI +L+  
Sbjct: 1362 EIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGT 1421

Query: 227  ISRHNE--------------------------TKALSETLEEKNKNTENRKELKERI--- 257
            I  H E                             ++E   EK K  E  ++LKER+   
Sbjct: 1422 IQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTIL 1481

Query: 258  --------FGKDEHVL---------TLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADI 300
                     G+ E  L         T ++ Q     L YES+KL +   +  +E  +  +
Sbjct: 1482 VKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE--ITTL 1539

Query: 301  KEESSAKQSKLANIDFRQKE 320
             EE S    KL  ++  Q+E
Sbjct: 1540 NEEDSISNLKLGTLNGSQEE 1559


>gi|33946321 ninein isoform 5 [Homo sapiens]
          Length = 2090

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 61/308 (19%), Positives = 127/308 (41%), Gaps = 55/308 (17%)

Query: 59  DEEIDHYCKHSEEIKDNCRNWKPTCDVFRKHEDY--------MQDQFTVYQGTVEKDKEM 110
           ++++ HY K  +E   +C+  +       ++E +        ++++    QG     KE 
Sbjct: 630 EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 689

Query: 111 YHDYICQYKEVLKQYQLKYSETPFSREYYEKKREHEEIQSRVLAC-----TEQLKMNETI 165
           +H+  C+++E  KQ Q+K  E     +   + +   E+++R+         E+  +  + 
Sbjct: 690 HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 749

Query: 166 FMKFRVPAPFPSLTKW-----TLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEI 220
           + + +V      L ++     T  +     E +++ K    L K   EL++  ++ME E 
Sbjct: 750 WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKEL--LEKHQRELQEGREKMETEC 807

Query: 221 NYLNQQISR--HNETKALSETLEEKNKNTENR-----KELKER--------IFGKDEHVL 265
           N    QI     ++ + ++E  E   ++ E R     K+L+E+         F KDE   
Sbjct: 808 NRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQ 867

Query: 266 -----------TLNKTQSSQLFLPYESQKLVRPIKMHSSEPRV---------ADIKEESS 305
                      TL + +++ L L  E + L +  K H +   V          D++  S 
Sbjct: 868 ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927

Query: 306 AKQSKLAN 313
            +QS L++
Sbjct: 928 TQQSLLSD 935



 Score = 36.6 bits (83), Expect = 0.066
 Identities = 66/320 (20%), Positives = 118/320 (36%), Gaps = 68/320 (21%)

Query: 67   KHSEEIKDNCRNWKPTCDVFRKHEDYMQDQF----TVYQGTVEKDKEMYHDYICQYKEVL 122
            K  E I +    +K   +   +  D +Q++     T Y   +E +KE+  +      E+ 
Sbjct: 1236 KMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELK 1295

Query: 123  KQYQLKYSETPFSREYYEKKREHEEIQSRVLACTEQL-KMNETIFMKFRVPAPFPSLTKW 181
            K  ++  +     + Y E K E+EE+   VL    ++ K+ E++  +        SL   
Sbjct: 1296 KMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENL 1355

Query: 182  TL----NIVNLRCETQDILKHASNLTKSSSELKKEVDEME-----------IEINYLNQQ 226
             +    NI+ L    ++ +    ++     E K+E   +E            EI +L+  
Sbjct: 1356 EIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGT 1415

Query: 227  ISRHNE--------------------------TKALSETLEEKNKNTENRKELKERI--- 257
            I  H E                             ++E   EK K  E  ++LKER+   
Sbjct: 1416 IQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTIL 1475

Query: 258  --------FGKDEHVL---------TLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADI 300
                     G+ E  L         T ++ Q     L YES+KL +   +  +E  +  +
Sbjct: 1476 VKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE--ITTL 1533

Query: 301  KEESSAKQSKLANIDFRQKE 320
             EE S    KL  ++  Q+E
Sbjct: 1534 NEEDSISNLKLGTLNGSQEE 1553


>gi|148536871 ninein isoform 1 [Homo sapiens]
          Length = 2046

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 61/308 (19%), Positives = 127/308 (41%), Gaps = 55/308 (17%)

Query: 59  DEEIDHYCKHSEEIKDNCRNWKPTCDVFRKHEDY--------MQDQFTVYQGTVEKDKEM 110
           ++++ HY K  +E   +C+  +       ++E +        ++++    QG     KE 
Sbjct: 630 EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 689

Query: 111 YHDYICQYKEVLKQYQLKYSETPFSREYYEKKREHEEIQSRVLAC-----TEQLKMNETI 165
           +H+  C+++E  KQ Q+K  E     +   + +   E+++R+         E+  +  + 
Sbjct: 690 HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 749

Query: 166 FMKFRVPAPFPSLTKW-----TLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEI 220
           + + +V      L ++     T  +     E +++ K    L K   EL++  ++ME E 
Sbjct: 750 WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKEL--LEKHQRELQEGREKMETEC 807

Query: 221 NYLNQQISR--HNETKALSETLEEKNKNTENR-----KELKER--------IFGKDEHVL 265
           N    QI     ++ + ++E  E   ++ E R     K+L+E+         F KDE   
Sbjct: 808 NRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQ 867

Query: 266 -----------TLNKTQSSQLFLPYESQKLVRPIKMHSSEPRV---------ADIKEESS 305
                      TL + +++ L L  E + L +  K H +   V          D++  S 
Sbjct: 868 ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927

Query: 306 AKQSKLAN 313
            +QS L++
Sbjct: 928 TQQSLLSD 935



 Score = 36.6 bits (83), Expect = 0.066
 Identities = 66/320 (20%), Positives = 118/320 (36%), Gaps = 68/320 (21%)

Query: 67   KHSEEIKDNCRNWKPTCDVFRKHEDYMQDQF----TVYQGTVEKDKEMYHDYICQYKEVL 122
            K  E I +    +K   +   +  D +Q++     T Y   +E +KE+  +      E+ 
Sbjct: 1236 KMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELK 1295

Query: 123  KQYQLKYSETPFSREYYEKKREHEEIQSRVLACTEQL-KMNETIFMKFRVPAPFPSLTKW 181
            K  ++  +     + Y E K E+EE+   VL    ++ K+ E++  +        SL   
Sbjct: 1296 KMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENL 1355

Query: 182  TL----NIVNLRCETQDILKHASNLTKSSSELKKEVDEME-----------IEINYLNQQ 226
             +    NI+ L    ++ +    ++     E K+E   +E            EI +L+  
Sbjct: 1356 EIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGT 1415

Query: 227  ISRHNE--------------------------TKALSETLEEKNKNTENRKELKERI--- 257
            I  H E                             ++E   EK K  E  ++LKER+   
Sbjct: 1416 IQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTIL 1475

Query: 258  --------FGKDEHVL---------TLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADI 300
                     G+ E  L         T ++ Q     L YES+KL +   +  +E  +  +
Sbjct: 1476 VKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE--ITTL 1533

Query: 301  KEESSAKQSKLANIDFRQKE 320
             EE S    KL  ++  Q+E
Sbjct: 1534 NEEDSISNLKLGTLNGSQEE 1553


>gi|148536869 ninein isoform 2 [Homo sapiens]
          Length = 2133

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 61/308 (19%), Positives = 127/308 (41%), Gaps = 55/308 (17%)

Query: 59  DEEIDHYCKHSEEIKDNCRNWKPTCDVFRKHEDY--------MQDQFTVYQGTVEKDKEM 110
           ++++ HY K  +E   +C+  +       ++E +        ++++    QG     KE 
Sbjct: 630 EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 689

Query: 111 YHDYICQYKEVLKQYQLKYSETPFSREYYEKKREHEEIQSRVLAC-----TEQLKMNETI 165
           +H+  C+++E  KQ Q+K  E     +   + +   E+++R+         E+  +  + 
Sbjct: 690 HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 749

Query: 166 FMKFRVPAPFPSLTKW-----TLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEI 220
           + + +V      L ++     T  +     E +++ K    L K   EL++  ++ME E 
Sbjct: 750 WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKEL--LEKHQRELQEGREKMETEC 807

Query: 221 NYLNQQISR--HNETKALSETLEEKNKNTENR-----KELKER--------IFGKDEHVL 265
           N    QI     ++ + ++E  E   ++ E R     K+L+E+         F KDE   
Sbjct: 808 NRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQ 867

Query: 266 -----------TLNKTQSSQLFLPYESQKLVRPIKMHSSEPRV---------ADIKEESS 305
                      TL + +++ L L  E + L +  K H +   V          D++  S 
Sbjct: 868 ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927

Query: 306 AKQSKLAN 313
            +QS L++
Sbjct: 928 TQQSLLSD 935



 Score = 36.6 bits (83), Expect = 0.066
 Identities = 66/320 (20%), Positives = 118/320 (36%), Gaps = 68/320 (21%)

Query: 67   KHSEEIKDNCRNWKPTCDVFRKHEDYMQDQF----TVYQGTVEKDKEMYHDYICQYKEVL 122
            K  E I +    +K   +   +  D +Q++     T Y   +E +KE+  +      E+ 
Sbjct: 1236 KMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELK 1295

Query: 123  KQYQLKYSETPFSREYYEKKREHEEIQSRVLACTEQL-KMNETIFMKFRVPAPFPSLTKW 181
            K  ++  +     + Y E K E+EE+   VL    ++ K+ E++  +        SL   
Sbjct: 1296 KMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENL 1355

Query: 182  TL----NIVNLRCETQDILKHASNLTKSSSELKKEVDEME-----------IEINYLNQQ 226
             +    NI+ L    ++ +    ++     E K+E   +E            EI +L+  
Sbjct: 1356 EIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGT 1415

Query: 227  ISRHNE--------------------------TKALSETLEEKNKNTENRKELKERI--- 257
            I  H E                             ++E   EK K  E  ++LKER+   
Sbjct: 1416 IQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTIL 1475

Query: 258  --------FGKDEHVL---------TLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADI 300
                     G+ E  L         T ++ Q     L YES+KL +   +  +E  +  +
Sbjct: 1476 VKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE--ITTL 1533

Query: 301  KEESSAKQSKLANIDFRQKE 320
             EE S    KL  ++  Q+E
Sbjct: 1534 NEEDSISNLKLGTLNGSQEE 1553


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 55/270 (20%), Positives = 108/270 (40%), Gaps = 36/270 (13%)

Query: 67   KHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLK-QY 125
            K  +++     N+K T   F+  +    D    Y+  +E+++ M  + +   KE  K   
Sbjct: 800  KTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS 859

Query: 126  QLKYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKWTLNI 185
             L   +T  S +  E + +  E+Q R         +NE   +K ++     +L       
Sbjct: 860  SLGALKTELSYKTQELQEKTREVQER---------LNEMEQLKEQLENRDSTLQTVEREK 910

Query: 186  VNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETLEEKNK 245
              +  + Q  L+    LT+   +LK+  + ++IE + L   I             +  N 
Sbjct: 911  TLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIH------------DTVNM 958

Query: 246  NTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADIKEESS 305
            N + +++L+  +    +H  T+N  +S        S+++ R + M   E    + K+E  
Sbjct: 959  NIDTQEQLRNALESLKQHQETINTLKSK------ISEEVSRNLHM---EENTGETKDEF- 1008

Query: 306  AKQSKLANIDFRQ--KENDTQIFNDSAVDN 333
              Q K+  ID +Q  +  +TQ       DN
Sbjct: 1009 --QQKMVGIDKKQDLEAKNTQTLTADVKDN 1036



 Score = 33.9 bits (76), Expect = 0.43
 Identities = 63/375 (16%), Positives = 148/375 (39%), Gaps = 50/375 (13%)

Query: 21   EQDISTKEEMIQRINKCCEDIKENKVTI-------CRIHETINATDEEIDHYCKHSEEIK 73
            ++++S  ++ I  I     ++K  ++T+         + + +N   EE+    K  + +K
Sbjct: 1147 QEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLK 1206

Query: 74   DNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKE---MYHDYICQYKEVLKQYQLKYS 130
            +  ++       F    D+++      + T  + KE   + H ++ +++E + + +   S
Sbjct: 1207 ELQKS-------FETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVS 1259

Query: 131  E-TPFSREYYEKKREHEEIQSRVLACTEQLK--------------MNET-IFMKFRVPAP 174
            E T       + ++ H ++Q  +    E+ +              MNE  +  +      
Sbjct: 1260 EKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKD 1319

Query: 175  FPSLTKWTLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQI----SRH 230
              +L +  +  + L  + Q+  +   +LTK    LK   + +E++ + L + I    ++ 
Sbjct: 1320 STTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKI 1379

Query: 231  NETKALSE---TLEEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRP 287
             E+++  E    ++EK+  T       E+   KD  +L   + +   L L    Q     
Sbjct: 1380 QESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALL---RIEIEMLGLSKRLQ----- 1431

Query: 288  IKMHSSEPRVADIKEESSAKQSKLANIDFRQKENDTQIF-NDSAVDNHSKCSHITTITSS 346
             + H     VA  K++    Q  L +   + KEN  +I       +   K +H       
Sbjct: 1432 -ESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQE 1490

Query: 347  QKFMQVRLLTPQKQS 361
            +   ++R+   +K++
Sbjct: 1491 ETINELRVNLSEKET 1505


>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
          Length = 971

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 68/373 (18%), Positives = 156/373 (41%), Gaps = 31/373 (8%)

Query: 63  DHYCKHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVL 122
           D    H  EI++  ++ +       K ++  ++   +++  VE   +M  +   + K+++
Sbjct: 69  DLQAAHRREIQELLKSQQDHSASVNKGQEKAEE---LHRMEVESLNKMLEELRLERKKLI 125

Query: 123 KQYQLKYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKWT 182
           + Y+ K ++   ++ +YE++ +  +      A + Q    +   ++         L K  
Sbjct: 126 EDYEGKLNK---AQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK-- 180

Query: 183 LNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQI--SRHNETKALSETL 240
             I  L+ E Q +   A +L     +L+  +   E  +  L +Q+  ++  E   LS+  
Sbjct: 181 -TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK 239

Query: 241 EEKNKNTENRKELKER---IFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSE--P 295
           E +++    R+ L+++   +  K  H+  L  TQ +Q       +  ++ ++   S    
Sbjct: 240 EVESELAAARERLQQQASDLVLKASHIGMLQATQMTQ-------EVTIKDLESEKSRVNE 292

Query: 296 RVADIKEESSAKQSKLANIDFRQKENDTQIFNDSAVDNHSKCSHITTITSSQKFMQVRL- 354
           R++ ++EE +  +SK  ++D  QK+   QI       N +K +         K +Q RL 
Sbjct: 293 RLSQLEEERAFLRSKTQSLDEEQKQ---QILELEKKVNEAKRTQQEYYERELKNLQSRLE 349

Query: 355 --LTPQKQSNSNQWSEKGDKDAEYGDKGTVRQVRESKCTSQAIYTEHFGK--SIENDSDE 410
             +T   +++S    E   K     +      +R+ K     +  +H     ++E D ++
Sbjct: 350 EEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQ 409

Query: 411 VEERAENFPRTSE 423
           +++  EN     E
Sbjct: 410 LQQELENLKEVLE 422


>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
          Length = 1140

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 68/373 (18%), Positives = 156/373 (41%), Gaps = 31/373 (8%)

Query: 63  DHYCKHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVL 122
           D    H  EI++  ++ +       K ++  ++   +++  VE   +M  +   + K+++
Sbjct: 189 DLQAAHRREIQELLKSQQDHSASVNKGQEKAEE---LHRMEVESLNKMLEELRLERKKLI 245

Query: 123 KQYQLKYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKWT 182
           + Y+ K ++   ++ +YE++ +  +      A + Q    +   ++         L K  
Sbjct: 246 EDYEGKLNK---AQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK-- 300

Query: 183 LNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQI--SRHNETKALSETL 240
             I  L+ E Q +   A +L     +L+  +   E  +  L +Q+  ++  E   LS+  
Sbjct: 301 -TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK 359

Query: 241 EEKNKNTENRKELKER---IFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSE--P 295
           E +++    R+ L+++   +  K  H+  L  TQ +Q       +  ++ ++   S    
Sbjct: 360 EVESELAAARERLQQQASDLVLKASHIGMLQATQMTQ-------EVTIKDLESEKSRVNE 412

Query: 296 RVADIKEESSAKQSKLANIDFRQKENDTQIFNDSAVDNHSKCSHITTITSSQKFMQVRL- 354
           R++ ++EE +  +SK  ++D  QK+   QI       N +K +         K +Q RL 
Sbjct: 413 RLSQLEEERAFLRSKTQSLDEEQKQ---QILELEKKVNEAKRTQQEYYERELKNLQSRLE 469

Query: 355 --LTPQKQSNSNQWSEKGDKDAEYGDKGTVRQVRESKCTSQAIYTEHFGK--SIENDSDE 410
             +T   +++S    E   K     +      +R+ K     +  +H     ++E D ++
Sbjct: 470 EEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQ 529

Query: 411 VEERAENFPRTSE 423
           +++  EN     E
Sbjct: 530 LQQELENLKEVLE 542


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
           sapiens]
          Length = 1116

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 63/295 (21%), Positives = 120/295 (40%), Gaps = 41/295 (13%)

Query: 120 EVLKQYQLKYSE----TPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPF 175
           E+ K+  L+  E    T +  +Y   + E++ +Q  + A  ++L++   +   F+  +  
Sbjct: 193 ELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSS 252

Query: 176 ----PSLTKWTL-NIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRH 230
               P + + T  N   L  E +          K    L+K ++EME+ I    Q ++  
Sbjct: 253 RTGEPCVAELTEENFQRLHAEHE-------RQAKELFLLRKTLEEMELRIETQKQTLNAR 305

Query: 231 NET-KALSETLEEKN---KNTENRKELKERIFGKDEHV------LTLNKTQSSQLFLPYE 280
           +E+ K L E L+ K    K TE   E   R+   + HV      L   + ++S L     
Sbjct: 306 DESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML----- 360

Query: 281 SQKLVRPIKMHSSEPRVADIKEESSAKQSKLANID--FRQKENDTQIFND----SAVDNH 334
            +++ R  +      +   ++     K SK+++++   R  E + Q+       S  +  
Sbjct: 361 REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE 420

Query: 335 SKCSHITTITSSQKFM--QVRLLTPQKQSNSNQWSEKGDKDAEYGDKGTVRQVRE 387
            +   +    S  KFM  +V  L  +  S   QW E   K A  G +  + QV++
Sbjct: 421 EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAA--GLQAEIGQVKQ 473



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 34/141 (24%), Positives = 64/141 (45%), Gaps = 13/141 (9%)

Query: 200 SNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETLEEKNKNTENRKELKERIFG 259
           +N  K   EL   +++++ E+  +  ++S   ++ A  ET    N   E RK L+E +  
Sbjct: 868 TNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKET-HLTNLRAERRKHLEEVLEM 926

Query: 260 KDEHVLT-LNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADIKEESSAKQSKLANIDFRQ 318
           K E +L  +++  ++   L   S K         ++  VA +K E      +L     +Q
Sbjct: 927 KQEALLAAISEKDANIALLELSSSK-------KKTQEEVAALKREKDRLVQQLK----QQ 975

Query: 319 KENDTQIFNDSAVDNHSKCSH 339
            +N  ++  D+  D+H K SH
Sbjct: 976 TQNRMKLMADNYEDDHFKSSH 996



 Score = 33.5 bits (75), Expect = 0.56
 Identities = 28/132 (21%), Positives = 62/132 (46%), Gaps = 10/132 (7%)

Query: 188 LRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHN-ETKALSETLEEKNKN 246
           ++ + + + +  S+      ELKK+   ++ EI  + Q++SR + E  AL   LE     
Sbjct: 436 MKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQ 495

Query: 247 TENRKE----LKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADIKE 302
             + K+    LKE +  K++    L +T+   L L  E ++ +    ++    ++ D+ E
Sbjct: 496 FSDSKQHIEVLKESLTAKEQRAAIL-QTEVDALRLRLEEKETM----LNKKTKQIQDMAE 550

Query: 303 ESSAKQSKLANI 314
           E   +  ++ ++
Sbjct: 551 EKGTQAGEIHDL 562



 Score = 31.2 bits (69), Expect = 2.8
 Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 56/302 (18%)

Query: 24  ISTKEEMIQRINKCCEDIKENKVTICRIHETINATDEEIDHYCKHSEEIKDNCRNWKPTC 83
           I  K+  I  + +   D++E ++ + + +  ++  + E        EE+K          
Sbjct: 384 IEMKDSKISSMERGLRDLEE-EIQMLKSNGALSTEERE--------EEMKQ--------M 426

Query: 84  DVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQLKYSETPFSREYYEKKR 143
           +V+R H  +M+++       VE+ KE       Q++E      LK        E  + K+
Sbjct: 427 EVYRSHSKFMKNK-------VEQLKEELSSKEAQWEE------LKKKAAGLQAEIGQVKQ 473

Query: 144 EHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKWTLNIVNLRCETQDILKHASNLT 203
           E     + +LA   +L   ET+  +F        + K +L     R              
Sbjct: 474 ELSRKDTELLALQTKL---ETLTNQFSDSKQHIEVLKESLTAKEQR-------------- 516

Query: 204 KSSSELKKEVDEMEIEINYLNQQISRHNETKALSETLEEKNKNTENRKELKERIFGKDEH 263
             ++ L+ EVD + + +      +++  +TK + +  EEK        +LK+ +  K+  
Sbjct: 517 --AAILQTEVDALRLRLEEKETMLNK--KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERK 572

Query: 264 VLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADIKEESSAKQSKLANIDFRQKENDT 323
           V  L K   +      + Q   +  +M S + RV  ++ +++   + L  ++    E + 
Sbjct: 573 VNVLQKKIEN-----LQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKER 627

Query: 324 QI 325
            I
Sbjct: 628 TI 629


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 56/304 (18%), Positives = 117/304 (38%), Gaps = 27/304 (8%)

Query: 126 QLKYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKWTLNI 185
           +L       S E Y      EE++ +     E+L++ E+   K  +      L K  L  
Sbjct: 185 ELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVES--EKSEIQLNVKEL-KRKLER 241

Query: 186 VNLRCETQDILKHASNLTKS----SSELKKEVDEMEIEINYLNQQISRH--NETKALSET 239
             L    Q +   A +L K     S++L+ +V+E E+  N LNQQ       + + + E 
Sbjct: 242 AKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW-NRLNQQQEEKMWRQEEKIQER 300

Query: 240 LEEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVAD 299
            E+  +  E  +E +E++  ++E +    +    Q  + +E ++ +R ++    E     
Sbjct: 301 EEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIR 360

Query: 300 IKEESSAKQSKLANIDFRQKENDTQIFNDSAVDNHSKCSHITTITSSQKFMQVRLLTPQK 359
            +EE   ++ K+   + RQ++       +  +                   Q   +  Q+
Sbjct: 361 EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE-----------------QEEKIREQE 403

Query: 360 QSNSNQWSEKGDKDAEYGDKGTVRQVRESKCTSQAIYTEHFGKSIENDSDEVEERAENFP 419
           +    Q  + G+++ +  ++    Q +E K   Q        K I    +++ E+ E   
Sbjct: 404 EMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ 463

Query: 420 RTSE 423
              E
Sbjct: 464 EQEE 467



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 56/304 (18%), Positives = 127/304 (41%), Gaps = 27/304 (8%)

Query: 12  LLLEFVFQYEQDISTKEEMIQRIN-KCCEDIKENKVTICRIHETINATDEEIDHYCKHSE 70
           LL +   Q E D   KE  +Q ++ K    ++EN+     +   +N   EE     +  E
Sbjct: 245 LLPQQQLQAEADHLGKE--LQSVSAKLQAQVEENE-----LWNRLNQQQEE--KMWRQEE 295

Query: 71  EIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQLKYS 130
           +I++     +   +  R+ E+ M+ Q  +     EK +    + + + +E +++ + K  
Sbjct: 296 KIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQ-EEMMWEKEEKIRELEEKMH 354

Query: 131 ETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKWTLNIVNLRC 190
           E    RE  EK++E E+I+       EQ K  E     +R         +       +R 
Sbjct: 355 EQEKIREQEEKRQEEEKIR-------EQEKRQEQEAKMWRQEEKIREQEE------KIRE 401

Query: 191 ETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETLEEKNKNTENR 250
           + + + +    + +   ++ ++ +EM+ +   + +Q  +  E +      EEK +  E  
Sbjct: 402 QEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 461

Query: 251 KELKERIFGKDEHVLTLN--KTQSSQLFLPYESQKL-VRPIKMHSSEPRVADIKEESSAK 307
            + +E   G+ E  +     K Q  +  +  + +K+  +  K+   E ++ + +E    +
Sbjct: 462 MQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ 521

Query: 308 QSKL 311
           + K+
Sbjct: 522 EEKM 525


>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
          Length = 1233

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 72/330 (21%), Positives = 135/330 (40%), Gaps = 51/330 (15%)

Query: 97  FTVYQGTVE-------KDKEMYHDYICQYKEVLKQYQLKYSE-------TPFS------- 135
           F V+QG VE       K++    + I +  E+ ++Y  +  E       T F+       
Sbjct: 133 FLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNI 192

Query: 136 -REYYEKKREHEE------IQSRVLACTEQLKM-----NETIFMKFR--VPAPFPSLTKW 181
             E  E K+E EE      ++  V+    QL++     NE    K    + +    + K 
Sbjct: 193 AAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKD 252

Query: 182 TLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLN-QQISRHNETKALSETL 240
              +  +  E ++  K    + +   +++KE+ E + E+N    Q I     T    + L
Sbjct: 253 KKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKL 312

Query: 241 EEKNKNTEN-RKELKERIFGKDE---HVLTLNKT-QSSQLFLPYESQKLVRPIKMHSSE- 294
           E   K+ +N +K  K+R    DE    +L++ K  Q  +  +  ESQ   R + +  ++ 
Sbjct: 313 EAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQV 372

Query: 295 PRVADIKEESSAKQSKLA------NIDFRQKENDTQIFNDSAVDNHSKCSH-ITTITSSQ 347
            +   +KEE+S + + LA      N D +  ++   +     V+  +K    +  I  +Q
Sbjct: 373 KKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQ 432

Query: 348 KFMQ--VRLLTPQKQSNSNQWSEKGDKDAE 375
           K ++     +T  KQS   Q   +G+   E
Sbjct: 433 KRIEKLEEYITTSKQSLEEQKKLEGELTEE 462



 Score = 33.5 bits (75), Expect = 0.56
 Identities = 58/298 (19%), Positives = 128/298 (42%), Gaps = 48/298 (16%)

Query: 44  NKVTICRIHETINATDEEIDHYCKHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGT 103
           N+V I ++++ + + ++EI+   K  ++++D  +                          
Sbjct: 231 NEVEIEKLNKELASKNKEIEKDKKRMDKVEDELK-------------------------- 264

Query: 104 VEKDKEMYHDYICQYKEVLKQYQLKYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNE 163
            EK KE+    + + +++ K+ + K SE    R  Y K +E+   + + L   ++   N 
Sbjct: 265 -EKKKEL-GKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNA 322

Query: 164 TIFMKFRVPAPFPSLTKWTLNIVNLRCETQDILKHAS-----NLTKSSSELKKE---VDE 215
               K R       L K  L++   R E ++ ++  S     +LT   +++KK     +E
Sbjct: 323 QKHYKKR-KGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEE 381

Query: 216 MEIEINYLNQQISRHN-ETKALSETLE-EKNKNTENRKELKERIFGKDEHVLTLNK---- 269
                  L Q++ + N + KA  + L+ E+ K  E   ++K+++   +E+   + K    
Sbjct: 382 ASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEY 441

Query: 270 -TQSSQLFLPYESQKLVRPI--KMHSSEPRVADIKEESSAKQSKLANIDFRQKENDTQ 324
            T S Q     E +KL   +  ++  ++ R+ +I +E +    +L +    ++E+  Q
Sbjct: 442 ITTSKQSL--EEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQ 497


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 60/266 (22%), Positives = 119/266 (44%), Gaps = 43/266 (16%)

Query: 88   KHEDYMQDQFTVYQ--GTVEKDKEMYHDYICQYKEVLKQYQLKYSETPFSREYYEKK--- 142
            KH  +M+  F +     + E +KEM        KE  ++ + + ++T   R+  E+K   
Sbjct: 829  KHWPWMKLYFKIKPLLKSAETEKEM-----ANMKEEFEKTKEELAKTEAKRKELEEKMVT 883

Query: 143  --REHEEIQSRVLACTEQL-----KMNETIFMKFRVPAPFPSLTKWTLNIVNLRCETQDI 195
              +E  ++Q +V A  + L     + ++ I  K ++ A    +T+   +   +  E   +
Sbjct: 884  LMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAE---L 940

Query: 196  LKHASNLTKSSSELKKEVDEMEIEINYL-NQQISRHNETKALSETL----EEKNKNTENR 250
                  L    SELKK++D++E+ +  +  ++ +  N+ K L+E +    E   K T+ +
Sbjct: 941  TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1000

Query: 251  KELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADIKEESSAKQSK 310
            K L+E       H  TL+  Q+ +     +    +   K+   E +V D+  E S +Q K
Sbjct: 1001 KALQE------AHQQTLDDLQAEE-----DKVNTLTKAKI-KLEQQVDDL--EGSLEQEK 1046

Query: 311  LANIDF----RQKENDTQIFNDSAVD 332
               +D     R+ E D ++  +S +D
Sbjct: 1047 KIRMDLERAKRKLEGDLKLAQESTMD 1072



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 73/389 (18%), Positives = 159/389 (40%), Gaps = 55/389 (14%)

Query: 23   DISTKEEMIQRINKC-------CEDIKENKVTICRIHETINATDEEIDHYCKHSEEIKDN 75
            D+  +E+ +  + K         +D++ +     +I   +     +++   K ++E   +
Sbjct: 1013 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMD 1072

Query: 76   CRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEV---LKQYQLKYSET 132
              N K   D   K +++   + +  Q  +E ++ +      + KE+   +++ + +    
Sbjct: 1073 IENDKQQLDEKLKKKEF---EMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAE 1129

Query: 133  PFSREYYEKKR-----EHEEIQSRVL----ACTEQLKMN---ETIFMKFRVPAPFPSLTK 180
              SR   EK+R     E EEI  R+     A + Q++MN   E  F K R      +L +
Sbjct: 1130 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL-Q 1188

Query: 181  WTLNIVNLRCETQDIL----KHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKA- 235
                   LR +  D +    +   NL +   +L+KE  EM++EI+ L   +   ++ K  
Sbjct: 1189 HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGN 1248

Query: 236  ---LSETLEEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHS 292
               +   LE++    + ++E ++R+         +N   + +  L  ES +  R +    
Sbjct: 1249 LEKMCRALEDQLSEIKTKEEEQQRL---------INDLTAQRARLQTESGEYSRQL---- 1295

Query: 293  SEPRVADIKEESSAKQSKLANIDFRQKENDTQIFNDSAV-----DNHSKCSHITTITSSQ 347
             + +   + + S  KQ+    I+  +++ + +I   SA+      +   C  +      +
Sbjct: 1296 -DEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEE 1354

Query: 348  KFMQVRLLTPQKQSNSN--QWSEKGDKDA 374
            +  +  L     ++NS   QW  K + DA
Sbjct: 1355 QEAKAELQRAMSKANSEVAQWRTKYETDA 1383



 Score = 32.7 bits (73), Expect = 0.95
 Identities = 55/316 (17%), Positives = 127/316 (40%), Gaps = 34/316 (10%)

Query: 31   IQRINKCCEDIKENKVTICRI-----------HETINATDEEIDHYCKHSEEIKDNCRNW 79
            ++R N  C  + + +    +I           H  + A+ +E         +IK+     
Sbjct: 1436 VERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEES 1495

Query: 80   KPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQLKYSETPFSREYY 139
                +  ++    +Q + +     + +  +  H+     +++ KQ + + SE   + E  
Sbjct: 1496 LDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL----EKIKKQVEQEKSELQAALEEA 1551

Query: 140  EKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAP----FPSLTKWTLNIVNLRCETQDI 195
            E   EHEE   ++L    QL++N+      R  A        + +  + IV     T D 
Sbjct: 1552 EASLEHEE--GKILRI--QLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDA 1607

Query: 196  -LKHASNLTKSSSELKKEVDEMEIEINYLNQQISR-----HNETKALSETLEEKNKNTEN 249
             ++  ++  +   +++ +++EMEI++N+ N+  +       N    L +T    +    +
Sbjct: 1608 EIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRS 1667

Query: 250  RKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADIKEESSAKQS 309
            +++LKE++    E    L + +  +L    E  +  R I    +E  + D  E      +
Sbjct: 1668 QEDLKEQL-AMVERRANLLQAEIEELRATLEQTERSRKI----AEQELLDASERVQLLHT 1722

Query: 310  KLANIDFRQKENDTQI 325
            +  ++   +K+ +T I
Sbjct: 1723 QNTSLINTKKKLETDI 1738


>gi|110815815 centlein isoform 1 [Homo sapiens]
          Length = 1406

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 52/256 (20%), Positives = 106/256 (41%), Gaps = 33/256 (12%)

Query: 119 KEVLKQYQLKYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSL 178
           KE+L+Q   K +E     + +EK+       SR L    +  M E  F+K        SL
Sbjct: 684 KEMLEQTLQKVTELENRLKSFEKR-------SRKLKEGNKKLMKENDFLK--------SL 728

Query: 179 TKWTLNIVNLR-CETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALS 237
            K        R  E + I+K + ++ K ++EL+ ++ E+E E+  L +Q++  N      
Sbjct: 729 LKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEAN------ 782

Query: 238 ETLEEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRV 297
             L  +N+   N  E   +   + +  +   K +S +    Y+ +  +  +K  +++   
Sbjct: 783 -ALRNENEELINPMEKSHQSADRAKSEMATMKVRSGR----YDCKTTMTKVKFKAAK--- 834

Query: 298 ADIKEESSAKQSKLANIDFRQKENDTQIFNDSAVDNHSKCSHITTITSSQKFMQVRLLTP 357
              K  S  +   + N   +   N  +  +    ++ S+ S  +   +SQ    + + T 
Sbjct: 835 ---KNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETS 891

Query: 358 QKQSNSNQWSEKGDKD 373
           QK S +    ++ + D
Sbjct: 892 QKISPTEDGKDQKESD 907



 Score = 35.4 bits (80), Expect = 0.15
 Identities = 36/146 (24%), Positives = 61/146 (41%), Gaps = 12/146 (8%)

Query: 123 KQYQLKYSETPFSREYYEKKREH-EEIQSRVLACTEQLKMNE-----TIFMKFRVPAPFP 176
           K  QLK  E    R+ +EK++E  + +Q+   A  EQLK  E     T   K +   P  
Sbjct: 543 KALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQ 602

Query: 177 -----SLTKWTLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHN 231
                S   W   +   + E Q+++    NL +   ELK  +   +  I  LN+ ++   
Sbjct: 603 LRQEDSDAVWN-ELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERR 661

Query: 232 ETKALSETLEEKNKNTENRKELKERI 257
           E +      +++ K +   K  KE +
Sbjct: 662 EEQLFRSGEDDEVKRSTPEKNGKEML 687



 Score = 34.3 bits (77), Expect = 0.33
 Identities = 29/140 (20%), Positives = 66/140 (47%), Gaps = 7/140 (5%)

Query: 188 LRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETLEEKNKNT 247
           L+ E  D++K    + + ++ L+KE  ++E +    +Q+I    +TK   +  EE+N+  
Sbjct: 183 LKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEI---KDTKECVQNKEEQNRLV 239

Query: 248 -ENRKELKERIFGKDEHVLT-LNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADIKEESS 305
            +N +E  +++  +   +L  L K +  +  L    +K     K+ + E  + + ++E  
Sbjct: 240 IKNLEEENKKLSTRCTDLLNDLEKLRKQEAHL--RKEKYSTDAKIKTFEDNLIEARKEVE 297

Query: 306 AKQSKLANIDFRQKENDTQI 325
             QSK   +  +     T++
Sbjct: 298 VSQSKYNALSLQLSNKQTEL 317



 Score = 32.7 bits (73), Expect = 0.95
 Identities = 37/181 (20%), Positives = 77/181 (42%), Gaps = 19/181 (10%)

Query: 122  LKQYQLKYSETPFSREYYEKKREHEEIQSRVLACTEQLK--------MNETIFMKFRVPA 173
            L+  QL+Y     + E  ++    + ++  +LA  E +K        M   I MK  +  
Sbjct: 1092 LEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIE 1151

Query: 174  PFPSLTKWTLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNET 233
                  K     VNL    +   +   NL K    L +E    ++ I+ L Q+++   + 
Sbjct: 1152 DLKFRQK-----VNLE-SNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKE 1205

Query: 234  KALSETLEEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSS 293
            K+  E + +K+K    +K+LK  +      V  +++T+S+   +   + K ++ + + S 
Sbjct: 1206 KSQYEQMYQKSKEELEKKDLKLTLL-----VSRISETESAMAEIETAASKQLQELALQSE 1260

Query: 294  E 294
            +
Sbjct: 1261 Q 1261


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.128    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,288,652
Number of Sequences: 37866
Number of extensions: 1051144
Number of successful extensions: 3872
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 305
Number of HSP's that attempted gapping in prelim test: 3467
Number of HSP's gapped (non-prelim): 708
length of query: 587
length of database: 18,247,518
effective HSP length: 108
effective length of query: 479
effective length of database: 14,157,990
effective search space: 6781677210
effective search space used: 6781677210
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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