Search of human proteins with 189217917

Search of human proteins with 189217917

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo
sapiens]
         (655 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]  1324   0.0  
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]   595   e-170
gi|24797153 faciogenital dysplasia protein [Homo sapiens]             580   e-165
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]   469   e-132
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]   469   e-132
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]   282   6e-76
gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]   197   2e-50
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform...   126   7e-29
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...   119   7e-27
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...   111   2e-24
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]          109   7e-24
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]          109   7e-24
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...    94   4e-19
gi|163644325 MCF.2 cell line derived transforming sequence-like ...    88   2e-17
gi|163644323 MCF.2 cell line derived transforming sequence-like ...    88   2e-17
gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]    88   2e-17
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...    88   3e-17
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [...    88   3e-17
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                87   4e-17
gi|13375827 phafin 2 [Homo sapiens]                                    86   8e-17
gi|194473700 Src homology 3 domain-containing guanine nucleotide...    86   8e-17
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]           84   3e-16
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]            84   3e-16
gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]              84   5e-16
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]     83   7e-16
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...    82   1e-15
gi|224586880 Ras protein-specific guanine nucleotide-releasing f...    82   2e-15
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa...    82   2e-15
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...    82   2e-15
gi|45439359 triple functional domain (PTPRF interacting) [Homo s...    82   2e-15

>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score = 1324 bits (3426), Expect = 0.0
 Identities = 655/655 (100%), Positives = 655/655 (100%)

Query: 1   MKGASEEKLASVSNLVTVFENSRTPEAAPRGQRLEDVHHRPECRPPESPGPREKTNVGEA 60
           MKGASEEKLASVSNLVTVFENSRTPEAAPRGQRLEDVHHRPECRPPESPGPREKTNVGEA
Sbjct: 1   MKGASEEKLASVSNLVTVFENSRTPEAAPRGQRLEDVHHRPECRPPESPGPREKTNVGEA 60

Query: 61  VGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQELLETEQAYVAR 120
           VGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQELLETEQAYVAR
Sbjct: 61  VGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQELLETEQAYVAR 120

Query: 121 LHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANP 180
           LHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANP
Sbjct: 121 LHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANP 180

Query: 181 RIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQH 240
           RIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQH
Sbjct: 181 RIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQH 240

Query: 241 HMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDL 300
           HMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDL
Sbjct: 241 HMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDL 300

Query: 301 WEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGA 360
           WEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGA
Sbjct: 301 WEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGA 360

Query: 361 QFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQI 420
           QFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQI
Sbjct: 361 QFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQI 420

Query: 421 EKRNETFKAAAQGPEGDIQEQELQSEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHH 480
           EKRNETFKAAAQGPEGDIQEQELQSEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHH
Sbjct: 421 EKRNETFKAAAQGPEGDIQEQELQSEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHH 480

Query: 481 CRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTGNVLPEAKEDKRRGILEKGSSA 540
           CRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTGNVLPEAKEDKRRGILEKGSSA
Sbjct: 481 CRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTGNVLPEAKEDKRRGILEKGSSA 540

Query: 541 TPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVT 600
           TPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVT
Sbjct: 541 TPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVT 600

Query: 601 VGPQGDPRVFQLQQSGQLYTFKAETEELKGRWVKAMERAASGWSPSWPNDGDLSD 655
           VGPQGDPRVFQLQQSGQLYTFKAETEELKGRWVKAMERAASGWSPSWPNDGDLSD
Sbjct: 601 VGPQGDPRVFQLQQSGQLYTFKAETEELKGRWVKAMERAASGWSPSWPNDGDLSD 655


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score =  595 bits (1533), Expect = e-170
 Identities = 296/548 (54%), Positives = 399/548 (72%), Gaps = 9/548 (1%)

Query: 105 KIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQF 164
           KI  ELL TE+AYV RL LLDQVF+ +LL+ A    +FP ++V  IFSNISSI  FHS+F
Sbjct: 209 KIANELLLTERAYVNRLDLLDQVFYCKLLEEANRG-SFPAEMVNKIFSNISSINAFHSKF 267

Query: 165 FLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVL 224
            LPEL++R+ +W   PRIGD++QKLAPFLKMY EYVK F+ A EL+   T++ P F+ V+
Sbjct: 268 LLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVV 327

Query: 225 TRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAA 284
             IQ  +  GSLTLQHHMLEPVQRIPRYE+LLK+Y++KLP  + D  DA+K+L++I +AA
Sbjct: 328 EEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAA 387

Query: 285 QHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLF 344
            HSN+AI +ME L+ L E+Y+ LG E+DIV+PSN L++EG +LK++ R     ERYLFLF
Sbjct: 388 SHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLF 447

Query: 345 NNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQE 404
           NNMLLYCVP+   VG++F VRTR+ + GMK+ E  + E+PH+F VSGK+RTLELQA S +
Sbjct: 448 NNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQ 507

Query: 405 EMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQSEELGLRAPQWVRDKMVTMC 464
           +   W++A Q  ID   +R+ETF+ A    + DI   E+ + ELG RAP+W+RD  VTMC
Sbjct: 508 DKEEWIKALQETIDAFHQRHETFRNAI-AKDNDI-HSEVSTAELGKRAPRWIRDNEVTMC 565

Query: 465 MRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTGNVLPE 524
           M+C+EPFNALTRRRHHCRACGYVVC +CSDY+A+L+YD  + ++VC  CY  ++G    +
Sbjct: 566 MKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISG--FTD 623

Query: 525 AKEDKRRGILEKGSSATPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQ 584
           ++E KR+GILE  S+     S++CSFLQ +  +  K   + WCVIP+ DPLVLY+Y APQ
Sbjct: 624 SEEKKRKGILEIESAEVSGNSVVCSFLQYM--EKSKPWQKAWCVIPKQDPLVLYMYGAPQ 681

Query: 585 DMRAHTSIPLLGYQVTVGPQGD--PRVFQLQQSGQLYTFKAETEELKGRWVKAMERAASG 642
           D+RA  +IPLLGY V   P+    P  F+L QS  +++F A++EELK +W+K +  A +G
Sbjct: 682 DVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTG 741

Query: 643 WSPSWPND 650
            +P  PN+
Sbjct: 742 ETPGGPNE 749


>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score =  580 bits (1495), Expect = e-165
 Identities = 302/612 (49%), Positives = 413/612 (67%), Gaps = 19/612 (3%)

Query: 49  PGPREKTNVGEAVGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQ 108
           PGP    +V  A+    R  S+   + L+ +   E   +  + + +     QE  +  VQ
Sbjct: 312 PGPPALASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQ 371

Query: 109 --------ELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQF 160
                   ELL+TE+AYV+RLHLLDQVF   LL+ AR+  +FP DVV  IFSNI SIY F
Sbjct: 372 QKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCF 431

Query: 161 HSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLF 220
           H QF LPEL++R+++W   PRIGD++QKLAPFLKMY EYVKNF+RA EL+ TWT++S  F
Sbjct: 432 HQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQF 491

Query: 221 QEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMI 280
           + ++  +Q  EA G+LTLQHHMLEPVQRIPRYELLLK+Y+ KLP  +PD  DAQK+L++I
Sbjct: 492 KVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELI 551

Query: 281 FSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERY 340
            +AA+HSNAAI +MER+  L +VY+ LG E+DIV P+  L++EG +LK+S +     +RY
Sbjct: 552 ATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRY 611

Query: 341 LFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQA 400
           L LFN+ LLYCVPR+  +G +F VR RIDV GM+++E  +   P +FLVSGKQR+LELQA
Sbjct: 612 LILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLELQA 671

Query: 401 RSQEEMISWMQAFQAAIDQIEKRNETFKAA-AQGPEGDIQEQELQSEELGLRAPQWVRDK 459
           R++EE   W+QA  + + + E+  ETFK   +   E +       + +LG RAP  +R+K
Sbjct: 672 RTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPTPIREK 731

Query: 460 MVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTG 519
            VTMCMRCQEPFN++T+RRHHC+ACG+VVC +CS++RA L YD+NR NRVC  CY  L G
Sbjct: 732 EVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVALHG 791

Query: 520 -----NVLPEAKEDKRRGILEKGSSATPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDP 574
                    +    +RR ILEK +S   + S++CSFL  + +K GK   + W V+P ++P
Sbjct: 792 VPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYM-EKGGKGWHKAWFVVPENEP 850

Query: 575 LVLYVYAAPQDMRAHTSIPLLGYQV---TVGPQGDPR-VFQLQQSGQLYTFKAETEELKG 630
           LVLY+Y APQD++A  S+PL+G++V     G + D R VF++ QS   + F  ETEEL+ 
Sbjct: 851 LVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQR 910

Query: 631 RWVKAMERAASG 642
           RW+  + RA  G
Sbjct: 911 RWMAVLGRAGRG 922


>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score =  469 bits (1208), Expect = e-132
 Identities = 248/566 (43%), Positives = 368/566 (65%), Gaps = 51/566 (9%)

Query: 106 IVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFF 165
           I QELL TE+ YV RLHLLDQVF   L     +    P +V+  IFSNISSI++FH QF 
Sbjct: 161 IAQELLHTEETYVKRLHLLDQVFCTRL-----TDAGIPPEVIMGIFSNISSIHRFHGQFL 215

Query: 166 LPELQRRL-DDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVL 224
           LPEL+ R+ ++W  NPR+GD++QKLAPFLKMY EYVKNF+RA  L++TWT +SPLF++V+
Sbjct: 216 LPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVV 275

Query: 225 TRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAA 284
             IQ  E  G+LTLQHHMLEPVQR+PRYELLLK+Y+++LP  APD+ DA+++L++I +AA
Sbjct: 276 HSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAA 335

Query: 285 QHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLF 344
            HSNAAI ++E++  L EVY++LG E+DIV+P+N L++EG + K+S +   P +R+LFLF
Sbjct: 336 NHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLF 395

Query: 345 NNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQE 404
           N+M+LYCVP++  +G +F VR ++D++G++V++++     H+F+++G++R+LELQ R++E
Sbjct: 396 NSMILYCVPKLRLMGQKFSVREKMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEE 455

Query: 405 EMISWMQAFQAAIDQIEKRNETFKA-------------------AAQGPEGDIQEQELQS 445
           E   W+Q  QA I++ ++ +ETFKA                    +  P   +   E  S
Sbjct: 456 EKKEWIQIIQATIEKHKQNSETFKAFGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSS 515

Query: 446 EELGLR----APQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKY 501
              GL     + +  RDK    C  C E FN++T+RRHHC+ CG V+C +CS+++AE   
Sbjct: 516 GAAGLEPRKLSSKTRRDKEKQSCKSCGETFNSITKRRHHCKLCGAVICGKCSEFKAE--- 572

Query: 502 DDNRPNRVCLHCYAFLTGNVLPEAKEDKRRGILEKGSSATPDQSLMCSFLQLIGDKWGKS 561
            ++R +RVC  C  FLT  V PE+         EK  +A P  SL+C  L+L   + G++
Sbjct: 573 -NSRQSRVCRDC--FLTQPVAPES--------TEKTPTADPQPSLLCGPLRL--SESGET 619

Query: 562 GPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVTVGPQGDPR-----VFQLQQSG 616
               W  IP  DP VL++    QD R   +IPL   +++V P  + R     V++LQ + 
Sbjct: 620 WSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSV-PDPEERLDSGHVWKLQWAK 678

Query: 617 QLYTFKAETEELKGRWVKAMERAASG 642
           Q +   A + EL+ +W++ +  AA G
Sbjct: 679 QSWYLSASSAELQQQWLETLSTAAHG 704


>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score =  469 bits (1208), Expect = e-132
 Identities = 248/566 (43%), Positives = 368/566 (65%), Gaps = 51/566 (9%)

Query: 106 IVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFF 165
           I QELL TE+ YV RLHLLDQVF   L     +    P +V+  IFSNISSI++FH QF 
Sbjct: 161 IAQELLHTEETYVKRLHLLDQVFCTRL-----TDAGIPPEVIMGIFSNISSIHRFHGQFL 215

Query: 166 LPELQRRL-DDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVL 224
           LPEL+ R+ ++W  NPR+GD++QKLAPFLKMY EYVKNF+RA  L++TWT +SPLF++V+
Sbjct: 216 LPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVV 275

Query: 225 TRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAA 284
             IQ  E  G+LTLQHHMLEPVQR+PRYELLLK+Y+++LP  APD+ DA+++L++I +AA
Sbjct: 276 HSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAA 335

Query: 285 QHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLF 344
            HSNAAI ++E++  L EVY++LG E+DIV+P+N L++EG + K+S +   P +R+LFLF
Sbjct: 336 NHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLF 395

Query: 345 NNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQE 404
           N+M+LYCVP++  +G +F VR ++D++G++V++++     H+F+++G++R+LELQ R++E
Sbjct: 396 NSMILYCVPKLRLMGQKFSVREKMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEE 455

Query: 405 EMISWMQAFQAAIDQIEKRNETFKA-------------------AAQGPEGDIQEQELQS 445
           E   W+Q  QA I++ ++ +ETFKA                    +  P   +   E  S
Sbjct: 456 EKKEWIQIIQATIEKHKQNSETFKAFGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSS 515

Query: 446 EELGLR----APQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKY 501
              GL     + +  RDK    C  C E FN++T+RRHHC+ CG V+C +CS+++AE   
Sbjct: 516 GAAGLEPRKLSSKTRRDKEKQSCKSCGETFNSITKRRHHCKLCGAVICGKCSEFKAE--- 572

Query: 502 DDNRPNRVCLHCYAFLTGNVLPEAKEDKRRGILEKGSSATPDQSLMCSFLQLIGDKWGKS 561
            ++R +RVC  C  FLT  V PE+         EK  +A P  SL+C  L+L   + G++
Sbjct: 573 -NSRQSRVCRDC--FLTQPVAPES--------TEKTPTADPQPSLLCGPLRL--SESGET 619

Query: 562 GPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVTVGPQGDPR-----VFQLQQSG 616
               W  IP  DP VL++    QD R   +IPL   +++V P  + R     V++LQ + 
Sbjct: 620 WSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSV-PDPEERLDSGHVWKLQWAK 678

Query: 617 QLYTFKAETEELKGRWVKAMERAASG 642
           Q +   A + EL+ +W++ +  AA G
Sbjct: 679 QSWYLSASSAELQQQWLETLSTAAHG 704


>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
          Length = 1430

 Score =  282 bits (722), Expect = 6e-76
 Identities = 204/648 (31%), Positives = 309/648 (47%), Gaps = 53/648 (8%)

Query: 25   PEAAPRGQRLEDVHHRPECRPPESPGPREKTNVGEAVGSEPRTVSRRYLNSLKNKLSSEA 84
            P  AP GQ      H+       S G  ++      +G  P        +S ++ +SSE+
Sbjct: 796  PYEAPDGQLQLGPRHQHS-----SSGASQEEQNDLGLGDLPSDEEEIINSSDEDDVSSES 850

Query: 85   WRKSCQPVTLS---GSGTQEPEKKIVQELLETEQAYVARLHLLDQVFFQELLKTARS-SK 140
             +    P+       +G +     I +E++ +E+ +V  L LL   F   +   +R   K
Sbjct: 851  SKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGK 910

Query: 141  AFPED-VVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEY 199
               ED ++  I   +  +Y+ +    L EL+ R+  WT   RI D+  K  P+LKMYS Y
Sbjct: 911  PVIEDRILNQILYYLPQLYELNRDL-LKELEERMLHWTEQQRIADIFVKKGPYLKMYSTY 969

Query: 200  VKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEY 259
            +K F++   LL     K+P F  V+   + S    +L L+H++L+PVQRIP+Y LLL +Y
Sbjct: 970  IKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDY 1029

Query: 260  IQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNT 319
            ++ L   A D  D Q AL ++   A H+N  + + +  Q L ++   L    +IV P   
Sbjct: 1030 LKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRV 1089

Query: 320  LLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELM 379
             L+EG ++K+S +   P  R  FLFN+ LLY  P  +Q G  +++   + +AGMKVR+  
Sbjct: 1090 FLKEGILMKLSRKVMQP--RMFFLFNDALLYTTP--VQSG-MYKLNNMLSLAGMKVRKPT 1144

Query: 380  DAEFPHSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQ 439
               + +   +   +R+  L A S  E   W++A   AI++  K+  TF  +    E D +
Sbjct: 1145 QEAYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDEADSE 1204

Query: 440  EQELQSEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAEL 499
             +E +   LG +AP W+ D   TMCM C   F  LT RRHHCRACG +VC  CS  +  L
Sbjct: 1205 NKE-EVSPLGSKAPIWIPDTRATMCMICTSEF-TLTWRRHHCRACGKIVCQACSSNKYGL 1262

Query: 500  KYDDNRPNRVCLHCYAFL-------------TGN-------------VLPEAKEDKRRGI 533
             Y  N+P RVC HC+  L              GN              +P  ++ K+   
Sbjct: 1263 DYLKNQPARVCEHCFQELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKKIPA 1322

Query: 534  LEKGSSATPDQSLMCSFL-QLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSI 592
              K  SA  + S M  +L +  G+K  K     W VI      VLY YAA +D+ A  S 
Sbjct: 1323 ALKEVSANTEDSSMSGYLYRSKGNK--KPWKHFWFVIKNK---VLYTYAASEDVAALESQ 1377

Query: 593  PLLGYQV--TVGPQGDPRVFQLQQSGQL-YTFKAETEELKGRWVKAME 637
            PLLG+ V        + +VFQL     L Y FKAE      +W++A +
Sbjct: 1378 PLLGFTVIQVKDENSESKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQ 1425


>gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]
          Length = 1462

 Score =  197 bits (502), Expect = 2e-50
 Identities = 166/583 (28%), Positives = 259/583 (44%), Gaps = 66/583 (11%)

Query: 106  IVQELLETEQAYVARLHLLDQVFFQELLKTA-----RSSKAFPEDVVRVIFSNISSIYQF 160
            I QELL +E+AYV  L  L+  F   +++               + +R   S + +I+  
Sbjct: 896  IAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDL 955

Query: 161  HSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLF 220
            H Q  L EL+ RL +W +  ++ DV          ++ ++  F+R   LL+     SP  
Sbjct: 956  H-QGILEELEERLSNWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRL 1014

Query: 221  QEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMI 280
               +   + S   GS T +H +L  VQR+ +Y++LL +Y+  L   + +  + Q AL +I
Sbjct: 1015 AAAVREFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLI 1074

Query: 281  FSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERY 340
                  +N ++ + E LQ L  +   +  + D++ P    L+EG ++K++ +   P  R+
Sbjct: 1075 SKVTDRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKNRRP--RH 1132

Query: 341  LFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQA 400
            LFL N++LLY  P   Q   +++++  + VA MKV   +  + P++  +   +  L L A
Sbjct: 1133 LFLMNDVLLYTYP---QKDGKYRLKNTLAVANMKVSRPVMEKVPYALKIETSESCLMLSA 1189

Query: 401  RSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGP-EGDIQEQELQSEELGLRAPQWVRDK 459
             S  E   W      A+       E +KA A       ++ +E     LG R P  V   
Sbjct: 1190 SSCAERDEWYGCLSRALP------EDYKAQALAAFHHSVEIRERLGVSLGERPPTLVPVT 1243

Query: 460  MVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFL-- 517
             V MCM C   F +LT RRHHC ACG +VC  CS  +  LKY  +R  +VC  C+  L  
Sbjct: 1244 HVMMCMNCGCDF-SLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKK 1302

Query: 518  TGNVLPEAKEDKRRGILEKGSSATPDQSLMCSFLQLI---------------------GD 556
             G  +P    ++   +    SS     S   S  Q I                     G+
Sbjct: 1303 RGRAVPGLMRERPVSMSFPLSSPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGE 1362

Query: 557  KWGKSG-----PRG-------WCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVTVGPQ 604
                SG      RG       W VI      VLY Y A +D  A  S+PLLG+  T+ P+
Sbjct: 1363 GSAISGYLSRCKRGKRHWKKLWFVIKGK---VLYTYMASEDKVALESMPLLGF--TIAPE 1417

Query: 605  GDP------RVFQLQQSGQL-YTFKAETEELKGRWVKAMERAA 640
             +        +F L     L Y+FKAE      RW++AME A+
Sbjct: 1418 KEEGSSEVGPIFHLYHKKTLFYSFKAEDTNSAQRWIEAMEDAS 1460


>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
            [Homo sapiens]
          Length = 1045

 Score =  126 bits (316), Expect = 7e-29
 Identities = 134/552 (24%), Positives = 225/552 (40%), Gaps = 76/552 (13%)

Query: 106  IVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFF 165
            I +E+  TE+ Y+  L ++   F      T     A PE +  +IF N   +++FH+ F 
Sbjct: 544  IAKEVSTTERTYLKDLEVITSWF----QSTVSKEDAMPEALKSLIFPNFEPLHKFHTNF- 598

Query: 166  LPELQRRLDDWTANP--------RIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKS 217
            L E+++RL  W            RIGDV+ K    +K  + ++     A E L      S
Sbjct: 599  LKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSS 658

Query: 218  PLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKAL 277
               +      +  +    L L   +L P+ R+  Y+ +L+   +  P    D  D + AL
Sbjct: 659  RRLENFCRDFELQKVC-YLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAAL 717

Query: 278  DMIFSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPM 337
              I       +  + +ME  Q L E+ + L   D++V P    +R G + K+S +     
Sbjct: 718  AEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGK--GLQ 775

Query: 338  ERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDA-EFPHSFLVSGKQRTL 396
            +R  FLFN++LLY   R +    QF+V  ++ + GM + E  D    PH   + G+++++
Sbjct: 776  QRMFFLFNDVLLY-TSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSI 834

Query: 397  ELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQSEELGLRAPQWV 456
             + A S+ EM  W++  Q AID  E      K+++  PE       L S     ++P   
Sbjct: 835  IVAASSRSEMEKWVEDIQMAIDLAE------KSSSPAPEF------LASSPPDNKSPDE- 881

Query: 457  RDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAF 516
                                             A  +D  +E   DD   +R  L   A 
Sbjct: 882  ---------------------------------ATAADQESE---DDLSASRTSLERQAP 905

Query: 517  LTGNVLPEAKEDKRRGILEKGSSATPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDPLV 576
              GN +      +   +     S   +  L  + L+   +  G    + W V        
Sbjct: 906  HRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQ--KLWVVFTN---FC 960

Query: 577  LYVYAAPQDMRAHTSIPLLGYQVTVGPQGD----PRVFQLQQSGQLYTFKAETEELKGRW 632
            L+ Y + QD     S+PLLGY +T+  + +      VF+L     +Y F+AE+E    RW
Sbjct: 961  LFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERW 1020

Query: 633  VKAMERAASGWS 644
            ++ +  A S  S
Sbjct: 1021 MEVIRSATSSAS 1032


>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
           sapiens]
          Length = 1054

 Score =  119 bits (299), Expect = 7e-27
 Identities = 102/387 (26%), Positives = 177/387 (45%), Gaps = 39/387 (10%)

Query: 95  SGSGTQEPEKK---------IVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPED 145
           +G   +EP  K         IV+E+L TE+ Y+  L ++   F   ++K      A P  
Sbjct: 519 AGMDCEEPRHKRVPADEAYFIVKEILATERTYLKDLEVITVWFRSAVVK----EDAMPAT 574

Query: 146 VVRVIFSNISSIYQFHSQFFLPELQRRLDDWT---------ANPRIGDVIQKLAPFLKMY 196
           ++ ++FSNI  IY+FH + FL E+++RL  W          ++ RIGD++ +    LK +
Sbjct: 575 LMTLLFSNIDPIYEFH-RGFLREVEQRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEF 633

Query: 197 SEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLL 256
           + Y +  +     L   T +    + V    +  +    L L   +L+P+QR+  Y LLL
Sbjct: 634 TSYFQRHDEVLTELEKATKRCKKLEAVYKEFELQKVC-YLPLNTFLLKPIQRLLHYRLLL 692

Query: 257 KEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDP 316
           +           D AD   AL  I          +  +E LQ L E+ + L   ++++ P
Sbjct: 693 RRLCGHYSPGHHDYADCHDALKAITEVTTTLQHILIRLENLQKLTELQRDLVGIENLIAP 752

Query: 317 SNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVR 376
               +REG + K++  +    +R  FLF++MLLY   + +   + F++R  + + GM V 
Sbjct: 753 GREFIREGCLHKLT--KKGLQQRMFFLFSDMLLY-TSKGVAGTSHFRIRGLLPLQGMLVE 809

Query: 377 ELMDAEF--PHSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKA----- 429
           E  D E+  PH F +   Q+T+ + A ++ E   WM    +AI   +   +T  A     
Sbjct: 810 E-SDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQAAKSGGDTAPALPGRT 868

Query: 430 ----AAQGPEGDIQEQELQSEELGLRA 452
                 + P     EQE + +  G+R+
Sbjct: 869 VCTRPPRSPNEVSLEQESEDDARGVRS 895



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 29/81 (35%), Positives = 45/81 (55%), Gaps = 6/81 (7%)

Query: 577  LYVYAAPQDMRAHTSIPLLGYQVTVGPQGD----PRVFQLQQSGQLYTFKAETEELKGRW 632
            L+ Y   QD     S+PLLGY V++  + D      VF+LQ    +Y F+AE++    RW
Sbjct: 958  LFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERW 1017

Query: 633  VKAMERAAS--GWSPSWPNDG 651
            ++ ++ A+S  G +PS   DG
Sbjct: 1018 MEVIQGASSSAGRAPSIVQDG 1038


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score =  111 bits (278), Expect = 2e-24
 Identities = 93/346 (26%), Positives = 154/346 (44%), Gaps = 33/346 (9%)

Query: 106 IVQELLETEQAYVARLHLLDQVFFQELLKTARSS--KAFPEDVVRVIFSNISSIYQFHSQ 163
           ++ E+L TE+ YV  L  L   F   + +    S  K   E+ V+V+FSNI  I + H  
Sbjct: 53  VLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKD 112

Query: 164 FFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEV 223
           F          +  +   +G+V  K      +Y EY  N E+A  LL    +K P  +  
Sbjct: 113 FLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVE-LNKIPTVRAF 171

Query: 224 LTR--IQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIF 281
           L    +     +  + L+ ++L P+QRI +Y LLLKE  ++ P + PD    Q AL  + 
Sbjct: 172 LLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMK 231

Query: 282 SAAQHSNAAITEMERLQDLWEVYQRL-GLE-DDIVDPSNTLLREGPVLKISFRRNDPMER 339
           +   + N    +ME+L+ L ++   + G E  ++ D    LL +G +LKIS    +  ER
Sbjct: 232 TVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKIS--AGNIQER 289

Query: 340 YLFLFNNMLLYCVPRVIQVGAQ-------------FQVRTRIDVAGMKVRELMDAE---F 383
             FLF+N+L+YC  +    G++             +  R RI+   M+V  + D      
Sbjct: 290 AFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYH 349

Query: 384 PHSFLV--------SGKQRTLELQARSQEEMISWMQAFQAAIDQIE 421
            + + V        + K +     A++ EE   W+ A     +Q E
Sbjct: 350 SNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRE 395


>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
          Length = 979

 Score =  109 bits (273), Expect = 7e-24
 Identities = 101/382 (26%), Positives = 172/382 (45%), Gaps = 37/382 (9%)

Query: 106 IVQELLETEQAYVARLHLLDQVFFQELLKTARSS--KAFPEDVVRVIFSNISSIYQFHSQ 163
           ++ EL +TE+ YV  L  L   F   + + A S   K   E+ V+++FSNI  I   H +
Sbjct: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86

Query: 164 FFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEV 223
           F     +    +  A   +G          ++Y EY  N E+A +LL        +   +
Sbjct: 87  FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFL 146

Query: 224 LT-RIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFS 282
           L   +     +  + L+ +++ P+QRI +Y L+LKE +++ P +  D A   +AL  + +
Sbjct: 147 LNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKA 206

Query: 283 AAQHSNAAITEMERLQDL--WEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERY 340
              + N A  +ME+L+ L  W+ +       +I D    +L  G +LKIS    +  ER 
Sbjct: 207 VCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS--SGNIQERV 264

Query: 341 LFLFNNMLLYCVPRVIQV--------GAQFQVRTRIDVAGMKVRELMD--AEFPHS--FL 388
            FLF+N+L+YC  +  ++        G ++  R RI+   M+V  + D  A+F  S   +
Sbjct: 265 FFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIV 324

Query: 389 VSG-------KQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGD---- 437
           V+G       K +     A++ EE   W +A       I K  E  K    G E D    
Sbjct: 325 VNGWKIHNTAKNKWFVCMAKTPEEKHEWFEA-------ILKERERRKGLKLGMEQDTWVM 377

Query: 438 IQEQELQSEELGLRAPQWVRDK 459
           I EQ  +  ++  R    ++D+
Sbjct: 378 ISEQGEKLYKMMCRQGNLIKDR 399


>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score =  109 bits (273), Expect = 7e-24
 Identities = 101/382 (26%), Positives = 172/382 (45%), Gaps = 37/382 (9%)

Query: 106 IVQELLETEQAYVARLHLLDQVFFQELLKTARSS--KAFPEDVVRVIFSNISSIYQFHSQ 163
           ++ EL +TE+ YV  L  L   F   + + A S   K   E+ V+++FSNI  I   H +
Sbjct: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86

Query: 164 FFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEV 223
           F     +    +  A   +G          ++Y EY  N E+A +LL        +   +
Sbjct: 87  FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFL 146

Query: 224 LT-RIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFS 282
           L   +     +  + L+ +++ P+QRI +Y L+LKE +++ P +  D A   +AL  + +
Sbjct: 147 LNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKA 206

Query: 283 AAQHSNAAITEMERLQDL--WEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERY 340
              + N A  +ME+L+ L  W+ +       +I D    +L  G +LKIS    +  ER 
Sbjct: 207 VCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS--SGNIQERV 264

Query: 341 LFLFNNMLLYCVPRVIQV--------GAQFQVRTRIDVAGMKVRELMD--AEFPHS--FL 388
            FLF+N+L+YC  +  ++        G ++  R RI+   M+V  + D  A+F  S   +
Sbjct: 265 FFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIV 324

Query: 389 VSG-------KQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGD---- 437
           V+G       K +     A++ EE   W +A       I K  E  K    G E D    
Sbjct: 325 VNGWKIHNTAKNKWFVCMAKTPEEKHEWFEA-------ILKERERRKGLKLGMEQDTWVM 377

Query: 438 IQEQELQSEELGLRAPQWVRDK 459
           I EQ  +  ++  R    ++D+
Sbjct: 378 ISEQGEKLYKMMCRQGNLIKDR 399


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 78/278 (28%), Positives = 130/278 (46%), Gaps = 16/278 (5%)

Query: 83   EAWRKSCQPVTLSGSGTQ---EPEKKIVQELLETEQAYVARLHLLDQVFFQELLKTARSS 139
            EA R + +P   S   ++   +  K +   LL+TEQ+YV  L  L Q + Q L +   S 
Sbjct: 1044 EAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV 1103

Query: 140  KAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANPRIGDV-IQKLAP--FLKMY 196
               P  +V  IF  I  + + H QF L +++  +  W A  ++G + +Q  +    + +Y
Sbjct: 1104 LCDPS-LVDEIFDQIPELLEHHEQF-LEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIY 1161

Query: 197  SEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLL 256
            S Y+ NF  A + +    +  P F + L +    E      L   M++PVQRIPRYELL+
Sbjct: 1162 SAYIDNFLNAKDAVRVAKEARPAFLKFLEQ-SMRENKEKQALSDLMIKPVQRIPRYELLV 1220

Query: 257  KEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRL-----GLED 311
            K+ ++  P   PD     +A   I   A+  N  +   E  +    V Q +     G+E 
Sbjct: 1221 KDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGME- 1279

Query: 312  DIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLL 349
            D+  P    LR+  V+++        +R LFLF ++++
Sbjct: 1280 DLQAPLRRFLRQEMVIEVK-AIGGKKDRSLFLFTDLIV 1316


>gi|163644325 MCF.2 cell line derived transforming sequence-like
           isoform a [Homo sapiens]
          Length = 1182

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 98/376 (26%), Positives = 158/376 (42%), Gaps = 66/376 (17%)

Query: 7   EKLASVSNLVTVFENSRTPEAAPRGQRLEDVHHRPEC---RPPESPGPREKTNVGEAVGS 63
           +K AS+  +    + S    AA + + ++ V  RPE     P  SPG R  +   E   S
Sbjct: 565 QKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGS---ENSSS 621

Query: 64  EPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPE------KKIVQELLETEQAY 117
           E   + R      K+++S     +        GS  +E E      + ++ ELL+TE+AY
Sbjct: 622 EGGALRRGPYRRAKSEMSESRQGR--------GSAGEEEESLAILRRHVMSELLDTERAY 673

Query: 118 VARLHL--------LDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPEL 169
           V  L          +D      LL T   +K        V+F N+  IY FH++ FL   
Sbjct: 674 VEELLCVLEGYAAEMDNPLMAHLLSTGLHNKK------DVLFGNMEEIYHFHNRIFL--- 724

Query: 170 QRRLDDWTANPR-IGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQ 228
            R L+++T  P  +G    +     ++Y +Y +N  R+  L    +D  P FQE   ++ 
Sbjct: 725 -RELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSD-CPFFQECQRKLD 782

Query: 229 SSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSN 288
                  L+L  ++L+PVQRI +Y+LLLKE + K         D Q+AL  I        
Sbjct: 783 HK-----LSLDSYLLKPVQRITKYQLLLKEML-KYSRNCEGAEDLQEALSSILGI----- 831

Query: 289 AAITEMERLQDLWEVYQRLGLEDDIVDPSNTLL----------REGPVLKISFRRNDPME 338
                ++ + D   +    G + ++ D    L+          + G        R  PM+
Sbjct: 832 -----LKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQ 886

Query: 339 RYLFLFNNMLLYCVPR 354
           R+LFL    +L+C  R
Sbjct: 887 RHLFLHEKAVLFCKKR 902


>gi|163644323 MCF.2 cell line derived transforming sequence-like
           isoform b [Homo sapiens]
          Length = 1129

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 98/376 (26%), Positives = 158/376 (42%), Gaps = 66/376 (17%)

Query: 7   EKLASVSNLVTVFENSRTPEAAPRGQRLEDVHHRPEC---RPPESPGPREKTNVGEAVGS 63
           +K AS+  +    + S    AA + + ++ V  RPE     P  SPG R  +   E   S
Sbjct: 512 QKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGS---ENSSS 568

Query: 64  EPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPE------KKIVQELLETEQAY 117
           E   + R      K+++S     +        GS  +E E      + ++ ELL+TE+AY
Sbjct: 569 EGGALRRGPYRRAKSEMSESRQGR--------GSAGEEEESLAILRRHVMSELLDTERAY 620

Query: 118 VARLHL--------LDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPEL 169
           V  L          +D      LL T   +K        V+F N+  IY FH++ FL   
Sbjct: 621 VEELLCVLEGYAAEMDNPLMAHLLSTGLHNKK------DVLFGNMEEIYHFHNRIFL--- 671

Query: 170 QRRLDDWTANPR-IGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQ 228
            R L+++T  P  +G    +     ++Y +Y +N  R+  L    +D  P FQE   ++ 
Sbjct: 672 -RELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSD-CPFFQECQRKLD 729

Query: 229 SSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSN 288
                  L+L  ++L+PVQRI +Y+LLLKE + K         D Q+AL  I        
Sbjct: 730 HK-----LSLDSYLLKPVQRITKYQLLLKEML-KYSRNCEGAEDLQEALSSILGI----- 778

Query: 289 AAITEMERLQDLWEVYQRLGLEDDIVDPSNTLL----------REGPVLKISFRRNDPME 338
                ++ + D   +    G + ++ D    L+          + G        R  PM+
Sbjct: 779 -----LKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQ 833

Query: 339 RYLFLFNNMLLYCVPR 354
           R+LFL    +L+C  R
Sbjct: 834 RHLFLHEKAVLFCKKR 849


>gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]
          Length = 1597

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 95/401 (23%), Positives = 180/401 (44%), Gaps = 41/401 (10%)

Query: 47   ESPGPREKTNVGEAVGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPV----TLSGSGTQEP 102
            E+PGP       +A+ S     S  YL  L    S   W++   PV    T+  S T E 
Sbjct: 1120 ETPGPSSPRQPRKALVS-----SESYLQRLSMASSGSLWQEI--PVVRNSTVLLSMTHED 1172

Query: 103  EK--KIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQF 160
            +K  ++  EL+ +E +Y+  L++    F  +L  + R++ +  E   + +FS +  +   
Sbjct: 1173 QKLQEVKFELIVSEASYLRSLNIAVDHF--QLSTSLRATLSNQEH--QWLFSRLQDVRDV 1228

Query: 161  HSQFFLPELQRRLDDWTANPRIGDVIQKLAP-FLKMYSEYVKNFERAAELLATWTDKSPL 219
             S  FL +L+   ++   + ++ DV+   AP F ++Y  YV N         +  + +  
Sbjct: 1229 -SATFLSDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSN 1287

Query: 220  FQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDM 279
            F+EVL +++S      L+L+  ++ P QRI R +LLL+  +++    + ++A+A KA   
Sbjct: 1288 FREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHA 1347

Query: 280  IFSAAQHSNAAITEMERLQDLWEVYQRLGLEDDI---VDPSNTLLREGPVLKISFRRNDP 336
            +    +  N  +  M R ++L  + Q++  E  I   +  S  L++ G +  + F  +  
Sbjct: 1348 LEQLIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGELTALEFSASPG 1407

Query: 337  MER-------YLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVREL-MDAEFPHSFL 388
            + R       +L LFN+ LL   PR    G++F V      + ++  +  M    PH  L
Sbjct: 1408 LRRKLNTRPVHLHLFNDCLLLSRPR---EGSRFLVFDHAPFSSIRGEKCEMKLHGPHKNL 1464

Query: 389  --------VSGKQRTLELQARSQEEMISWMQAFQAAIDQIE 421
                      G Q     +  +Q E + W+ A     ++++
Sbjct: 1465 FRLFLRQNTQGAQAEFLFRTETQSEKLRWISALAMPREELD 1505


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 84/353 (23%), Positives = 149/353 (42%), Gaps = 40/353 (11%)

Query: 97  SGTQEPEKKIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISS 156
           S   +    ++ E+L TE+ Y+  L  + + + ++  K A     F E+ +R IF NI  
Sbjct: 279 SSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRA---DMFSEEQLRTIFGNIED 335

Query: 157 IYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWT-- 214
           IY+    F     QR   +      +G    +     ++YSEY  N   A   L+  T  
Sbjct: 336 IYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKL 395

Query: 215 DKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQ 274
            K   F E    +Q       ++L   +L PVQ+I +Y L L E ++    Q  D  D +
Sbjct: 396 SKYVYFFEACRLLQKMI---DISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVE 452

Query: 275 KALDMIFSAAQHSNAAITEMERLQDL--WEVYQRLGLEDDIVDPSNTLLREGPVLKISFR 332
            AL  + + AQ  N     +E +  +  W+        +D++  S+ L+  G + +++  
Sbjct: 453 AALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQP 512

Query: 333 RNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGK 392
           +    +R  FLF++ L+YC   +++    +  + R+D+ G++V +L D          GK
Sbjct: 513 QAKSQQRMFFLFDHQLIYCKKDLLRRDVLY-YKGRLDMDGLEVVDLED----------GK 561

Query: 393 QRTLE-------------------LQARSQEEMISWMQAFQAAIDQIEKRNET 426
            R L                    L  R  E+   W++AF    +Q++   ET
Sbjct: 562 DRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET 614


>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
           [Homo sapiens]
          Length = 670

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 84/353 (23%), Positives = 149/353 (42%), Gaps = 40/353 (11%)

Query: 97  SGTQEPEKKIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISS 156
           S   +    ++ E+L TE+ Y+  L  + + + ++  K A     F E+ +R IF NI  
Sbjct: 279 SSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRA---DMFSEEQLRTIFGNIED 335

Query: 157 IYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWT-- 214
           IY+    F     QR   +      +G    +     ++YSEY  N   A   L+  T  
Sbjct: 336 IYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKL 395

Query: 215 DKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQ 274
            K   F E    +Q       ++L   +L PVQ+I +Y L L E ++    Q  D  D +
Sbjct: 396 SKYVYFFEACRLLQKMI---DISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVE 452

Query: 275 KALDMIFSAAQHSNAAITEMERLQDL--WEVYQRLGLEDDIVDPSNTLLREGPVLKISFR 332
            AL  + + AQ  N     +E +  +  W+        +D++  S+ L+  G + +++  
Sbjct: 453 AALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQP 512

Query: 333 RNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGK 392
           +    +R  FLF++ L+YC   +++    +  + R+D+ G++V +L D          GK
Sbjct: 513 QAKSQQRMFFLFDHQLIYCKKDLLRRDVLY-YKGRLDMDGLEVVDLED----------GK 561

Query: 393 QRTLE-------------------LQARSQEEMISWMQAFQAAIDQIEKRNET 426
            R L                    L  R  E+   W++AF    +Q++   ET
Sbjct: 562 DRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET 614


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 89/369 (24%), Positives = 154/369 (41%), Gaps = 39/369 (10%)

Query: 99   TQEPEKKIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIY 158
            T+   +  + EL+ TE+ YV  L L+ ++F + L++    S+   E  V +IF N   + 
Sbjct: 1234 TERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLME----SELLTEKEVAMIFVNWKELI 1289

Query: 159  QFHSQFFLPELQRRLDDWTANP--RIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDK 216
              + +       R+       P   IGD++    P ++ Y  +       A L+   TD+
Sbjct: 1290 MCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDE 1349

Query: 217  SPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKA 276
            +P F+E + R+        + L   +L+P+QR+ RY L++K  ++  P   PD +  + A
Sbjct: 1350 APDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHA 1409

Query: 277  LDMIFSAAQHSNAAITEME---RLQDLWEVYQRLGLEDDIVDPSNT-------LLREGPV 326
            L+         N  + E E   RL+ +    Q  GL + +V  S T        L  G +
Sbjct: 1410 LEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKL 1469

Query: 327  LKISFRRNDPMERYLFLFNNMLLYC----------VPRVIQVGAQFQ---VRTRIDVAGM 373
             K    +    E Y FLFN+ LL              +V    +  Q    +T I +  +
Sbjct: 1470 YKAKSNK----ELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPIFLNEV 1525

Query: 374  KVRELMDAEFPHS-FLVSGKQRTLELQARSQEEMISWMQAFQAAID-----QIEKRNETF 427
             V+   D       F +S   R   L+A S  E  +W+Q  +AA +     + +KR + +
Sbjct: 1526 LVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASELYIETEKKKREKAY 1585

Query: 428  KAAAQGPEG 436
               +Q   G
Sbjct: 1586 LVRSQRATG 1594


>gi|13375827 phafin 2 [Homo sapiens]
          Length = 249

 Score = 86.3 bits (212), Expect = 8e-17
 Identities = 56/205 (27%), Positives = 91/205 (44%), Gaps = 26/205 (12%)

Query: 316 PSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKV 375
           P   L+ EG + K+   R  P  R  FLFN++L+Y    ++    ++  +  I +  + +
Sbjct: 32  PGRVLIGEGVLTKLC--RKKPKARQFFLFNDILVY--GNIVIQKKKYNKQHIIPLENVTI 87

Query: 376 RELMD-AEFPHSFLVSGKQRTLELQARSQEEMISWMQAFQAAI-DQIEKRNETFKAAAQG 433
             + D  +  + +L+    ++  + A +  E   WM      + D + K  +T       
Sbjct: 88  DSIKDEGDLRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCVTDLLSKSGKT------- 140

Query: 434 PEGDIQEQELQSEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCS 493
           P  +              A  WV D   T+CMRCQ+       RRHHCR CG+VVC  CS
Sbjct: 141 PSNE-------------HAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCS 187

Query: 494 DYRAELKYDDNRPNRVCLHCYAFLT 518
           + R  L    ++P R+C  CY  L+
Sbjct: 188 EKRFLLPSQSSKPVRICDFCYDLLS 212


>gi|194473700 Src homology 3 domain-containing guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 871

 Score = 86.3 bits (212), Expect = 8e-17
 Identities = 76/315 (24%), Positives = 148/315 (46%), Gaps = 35/315 (11%)

Query: 53  EKTNVGEAVGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQELLE 112
           E++   E    E   +  + L S  ++LS+   +   Q V    S  +   ++ + E++ 
Sbjct: 394 EESEPKEQKSDEKIVIHHKPLRSTWSQLSAVKRKGLSQTV----SQEERKRQEAIFEVIS 449

Query: 113 TEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRV----IFSNISSIYQFHSQFFLPE 168
           +E +Y+  L +L ++F        ++SK   + + +     +FSNI+ + +   +FF+ E
Sbjct: 450 SEHSYLLSLEILIRMF--------KNSKELSDTMTKTERHHLFSNITDVCEASKKFFI-E 500

Query: 169 LQRRLDDWTANPRIGDVIQK-----LAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEV 223
           L+ R  +      I D+++K       P++K  +  V       +LLAT    +P F+EV
Sbjct: 501 LEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLAT----NPSFKEV 556

Query: 224 LTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSA 283
           L+RI+S E   +L +   ++ P+QR+ R  LL+    QK P  +P     ++AL  +   
Sbjct: 557 LSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKL 616

Query: 284 AQHSNAAITEMERLQDLWEVYQRLGLE---DDIVDPSNTLLREGPVLK------ISFRRN 334
            +  N    +MER + ++ +  +L  +     +V  S  L++ G +        +  RR 
Sbjct: 617 VRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDTVLFSRRT 676

Query: 335 DPMERYLFLFNNMLL 349
              + Y FLFN++L+
Sbjct: 677 SKQQVYFFLFNDVLI 691


>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
          Length = 2986

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 79/338 (23%), Positives = 160/338 (47%), Gaps = 41/338 (12%)

Query: 106  IVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVV---RVIFSNISSIYQFHS 162
            ++ EL++TE+ YV  L ++ + F + +       K  PED+    +++F NI  IY +H 
Sbjct: 1933 VLNELVQTEKDYVKDLGIVVEGFMKRI-----EEKGVPEDMRGKDKIVFGNIHQIYDWHK 1987

Query: 163  QFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQE 222
             FFL EL++ + +     R+  +  K    L +Y  Y +N  R+  ++A +      F+E
Sbjct: 1988 DFFLAELEKCIQE---QDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY---DAYFEE 2041

Query: 223  VLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFS 282
            V       E +  LTL   +++P+QRI +Y+LLLK++++       + +D +KA++++  
Sbjct: 2042 V-----KQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCL 2096

Query: 283  AAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISF---RRNDPMER 339
              +  N          D+  + +  G E  +      LL++     I      ++   ER
Sbjct: 2097 VPKRCN----------DMMNLGRLQGFEGTLT-AQGKLLQQDTFYVIELDAGMQSRTKER 2145

Query: 340  YLFLFNNMLLYC-VPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRT--L 396
             +FLF  ++++  + R   +   +  +  I +  + + E +D + P  F +  ++ +  +
Sbjct: 2146 RVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDND-PCKFALMNRETSERV 2204

Query: 397  ELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGP 434
             LQA + +   +W+Q     I+Q+ +    F  A Q P
Sbjct: 2205 VLQAANADIQQAWVQ----DINQVLETQRDFLNALQSP 2238



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 70/250 (28%), Positives = 117/250 (46%), Gaps = 32/250 (12%)

Query: 106  IVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFF 165
            I+ ELL+TE+AYV  LH   + +  E+            +   +IF NI  IY FH+  F
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIF 1344

Query: 166  LPELQRRLDDWTANPR-IGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVL 224
            L EL++    +   P  +G      A   +MY  Y KN   + +L+         F E+ 
Sbjct: 1345 LKELEK----YEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLIL--EHAGTFFDEIQ 1398

Query: 225  TRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAA 284
             R   + +  S     ++++PVQRI +Y+LLLKE    L      + + +  L+++ S  
Sbjct: 1399 QRHGLANSISS-----YLIKPVQRITKYQLLLKEL---LTCCEEGKGELKDGLEVMLSVP 1450

Query: 285  QHSNAA--ITEMERLQDLWEVYQRLGLED--DIVDPSNTLLREGPVLKISFRRNDPMERY 340
            + +N A  ++ +E   +  +V   L L+D   + DP  +L+R+G             ER+
Sbjct: 1451 KKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDP-KSLIRKG------------RERH 1497

Query: 341  LFLFNNMLLY 350
            LFLF   L++
Sbjct: 1498 LFLFEISLVF 1507


>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
          Length = 1289

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 79/338 (23%), Positives = 160/338 (47%), Gaps = 41/338 (12%)

Query: 106 IVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVV---RVIFSNISSIYQFHS 162
           ++ EL++TE+ YV  L ++ + F + +       K  PED+    +++F NI  IY +H 
Sbjct: 236 VLNELVQTEKDYVKDLGIVVEGFMKRI-----EEKGVPEDMRGKDKIVFGNIHQIYDWHK 290

Query: 163 QFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQE 222
            FFL EL++ + +     R+  +  K    L +Y  Y +N  R+  ++A +      F+E
Sbjct: 291 DFFLAELEKCIQE---QDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY---DAYFEE 344

Query: 223 VLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFS 282
           V       E +  LTL   +++P+QRI +Y+LLLK++++       + +D +KA++++  
Sbjct: 345 V-----KQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCL 399

Query: 283 AAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISF---RRNDPMER 339
             +  N          D+  + +  G E  +      LL++     I      ++   ER
Sbjct: 400 VPKRCN----------DMMNLGRLQGFEGTLT-AQGKLLQQDTFYVIELDAGMQSRTKER 448

Query: 340 YLFLFNNMLLYC-VPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRT--L 396
            +FLF  ++++  + R   +   +  +  I +  + + E +D + P  F +  ++ +  +
Sbjct: 449 RVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDND-PCKFALMNRETSERV 507

Query: 397 ELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGP 434
            LQA + +   +W+Q     I+Q+ +    F  A Q P
Sbjct: 508 VLQAANADIQQAWVQ----DINQVLETQRDFLNALQSP 541


>gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]
          Length = 841

 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 91/342 (26%), Positives = 155/342 (45%), Gaps = 39/342 (11%)

Query: 99  TQEPEKKIVQELL----ETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNI 154
           T  P+++ +QE L     +E +Y+  L LL   F   +L  A      P D    +FSN+
Sbjct: 410 TLSPQERRMQESLFEVVTSEASYLRSLRLLTDTF---VLSQALRDTLTPRDH-HTLFSNV 465

Query: 155 SSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQ-----KLAPFLKMYSEYVKNFERAAEL 209
             + Q  S+ FL  L  R+    ++P I D+        + PF  +Y +YV+N +   E 
Sbjct: 466 QRV-QGVSERFLATLLSRV---RSSPHISDLCDVVHAHAVGPF-SVYVDYVRNQQYQEET 520

Query: 210 LATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPD 269
            +   D +  F   L R+QS      L L   +L P QRI R  +LL+  +++    +  
Sbjct: 521 YSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSR 580

Query: 270 QADAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLED----DIVDPSNTLLREGP 325
           Q +AQKAL  +    +  +A +  M++ ++L  + QRL         +V  S  L  +G 
Sbjct: 581 QENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGE 640

Query: 326 VLKISFRRNDPM----ERY----LFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRE 377
           + ++  RR   +     R+    L LF+++LL   P+    G + QV      + ++ ++
Sbjct: 641 LTELGCRRGGVLFASRPRFTPLCLLLFSDLLLITQPK---SGQRLQVLDYAHRSLVQAQQ 697

Query: 378 LMDAEFPHSFLVS------GKQRTLELQARSQEEMISWMQAF 413
           + D   P +F +S      G+     LQA S  +M  W+ AF
Sbjct: 698 VPDPSGPPTFRLSLLSNHQGRPTHRLLQASSLSDMQRWLGAF 739


>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
          Length = 845

 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 84/345 (24%), Positives = 152/345 (44%), Gaps = 21/345 (6%)

Query: 90  QPVTLSGSGTQEPEKKI-VQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVR 148
           +PV++    T+  ++   ++E+ +TE+ Y   L  + Q F + L +  +     P+D+  
Sbjct: 181 EPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLK-----PQDI-E 234

Query: 149 VIFSNISSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAE 208
           +IF NI  + + H+ F L E++  L    A   +  V  K      +Y  Y    E A++
Sbjct: 235 IIFINIEDLLRVHTHF-LKEMKEALGTPGA-ANLYQVFIKYKERFLVYGRYCSQVESASK 292

Query: 209 LLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAP 268
            L          Q  L        +G  TL+  ++ P+QR+ +Y LLL+E + K   +A 
Sbjct: 293 HLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELV-KHTQEAM 351

Query: 269 DQADAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLK 328
           ++ + + ALD +   AQ  N    + E L+ +      +   D  +        +G +  
Sbjct: 352 EKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKI 411

Query: 329 ISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAE-----F 383
            S  R   M+RY FL +  LL C  R    G  + ++  +++   +VR+    +     +
Sbjct: 412 TSVERRSKMDRYAFLLDKALLICKRR----GDSYDLKDFVNLHSFQVRDDSSGDRDNKKW 467

Query: 384 PHSFLVSGKQ--RTLELQARSQEEMISWMQAFQAAIDQIEKRNET 426
            H FL+   Q  +  EL  +++E    WM+ F+ AI  I   N T
Sbjct: 468 SHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENAT 512


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 1386

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 98/343 (28%), Positives = 154/343 (44%), Gaps = 35/343 (10%)

Query: 86  RKSCQPVTLSGSGTQEPEKKIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPED 145
           R    PV + GS      +++ +E++ETE+AYV  L  + + +   LL       +  + 
Sbjct: 86  RLHLSPVGIPGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQ- 144

Query: 146 VVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFER 205
            V  +F+NI  IY+F S     EL   L++ ++   I +   + +    +Y+ Y  N+  
Sbjct: 145 -VGTLFANIEDIYEFSS-----ELLEDLENSSSAGGIAECFVQRSEDFDIYTLYCMNYPS 198

Query: 206 AAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPA 265
           +  LL   +   P    +  R   ++   SL LQ  +L+PVQRI +Y LLL+E + K  A
Sbjct: 199 SLALLRELSLSPPAALWLQER--QAQLRHSLPLQSFLLKPVQRILKYHLLLQE-LGKHWA 255

Query: 266 QAPDQAD---AQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLR 322
           + P        ++A+  + + A + N    + E    L EV +RLG       P  +   
Sbjct: 256 EGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLG---GWTGPELSAFG 312

Query: 323 EGPVLKISFR-------RNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKV 375
           E  VL+ +FR       R    ER LFLF+ MLL    R    G ++  +  I    + V
Sbjct: 313 E-LVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRR----GLEYTYKGHIFCCNLSV 367

Query: 376 RELMDAEFPHSFLVSG----KQRTLELQARSQEEMISWMQAFQ 414
            E      P  F VS     K R L LQA++QEE   W+   Q
Sbjct: 368 SE--SPRDPLGFKVSDLTIPKHRHL-LQAKNQEEKRLWIHCLQ 407


>gi|224586880 Ras protein-specific guanine nucleotide-releasing
           factor 1 isoform 3 [Homo sapiens]
          Length = 1257

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 71/294 (24%), Positives = 129/294 (43%), Gaps = 22/294 (7%)

Query: 76  LKNKLSSEAWRKSCQPVTLSG-SGTQEPEKKIVQELLETEQAYVARLHLLDQVFFQELLK 134
           L+  L    W+   Q    S  + +     ++V  +LE E  YV +LH+L   F + L  
Sbjct: 213 LRGWLCRRKWKTIIQDYIRSPHADSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRM 272

Query: 135 TARSSK-AFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFL 193
            A S K     D V  IF N  +I   H Q F   L+ R+  W     + D+   L P L
Sbjct: 273 AASSKKPPITHDDVSSIFLNSETIMFLH-QIFYQGLKARISSWPTLV-LADLFDILLPML 330

Query: 194 KMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYE 253
            +Y E+V+N + + ++LA        F ++L   ++       TL+  +  P+ +IPRY 
Sbjct: 331 NIYQEFVRNHQYSLQILAHCKQNRD-FDKLLKHYEAKPDCEERTLETFLTYPMFQIPRYI 389

Query: 254 LLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLE--D 311
           L L E +   P +  ++     A   +   ++  +  ++E E ++    + +R+ +E  +
Sbjct: 390 LTLHELLAHTPHEHVERNSLDYAKSKLEELSRIMHDEVSETENIRKNLAI-ERMIIEGCE 448

Query: 312 DIVDPSNTLLREGPVLKISFRRNDPM--------------ERYLFLFNNMLLYC 351
            ++D S T +R+G ++++       +              ER  FLF+  L+ C
Sbjct: 449 ILLDTSQTFVRQGSLIQVPMSEKGKITRGRLGSLSLKKEGERQCFLFSKHLIIC 502


>gi|24797099 Ras protein-specific guanine nucleotide-releasing
           factor 1 isoform 1 [Homo sapiens]
          Length = 1273

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 71/294 (24%), Positives = 129/294 (43%), Gaps = 22/294 (7%)

Query: 76  LKNKLSSEAWRKSCQPVTLSG-SGTQEPEKKIVQELLETEQAYVARLHLLDQVFFQELLK 134
           L+  L    W+   Q    S  + +     ++V  +LE E  YV +LH+L   F + L  
Sbjct: 213 LRGWLCRRKWKTIIQDYIRSPHADSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRM 272

Query: 135 TARSSK-AFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFL 193
            A S K     D V  IF N  +I   H Q F   L+ R+  W     + D+   L P L
Sbjct: 273 AASSKKPPITHDDVSSIFLNSETIMFLH-QIFYQGLKARISSWPTLV-LADLFDILLPML 330

Query: 194 KMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYE 253
            +Y E+V+N + + ++LA        F ++L   ++       TL+  +  P+ +IPRY 
Sbjct: 331 NIYQEFVRNHQYSLQILAHCKQNRD-FDKLLKHYEAKPDCEERTLETFLTYPMFQIPRYI 389

Query: 254 LLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLE--D 311
           L L E +   P +  ++     A   +   ++  +  ++E E ++    + +R+ +E  +
Sbjct: 390 LTLHELLAHTPHEHVERNSLDYAKSKLEELSRIMHDEVSETENIRKNLAI-ERMIIEGCE 448

Query: 312 DIVDPSNTLLREGPVLKISFRRNDPM--------------ERYLFLFNNMLLYC 351
            ++D S T +R+G ++++       +              ER  FLF+  L+ C
Sbjct: 449 ILLDTSQTFVRQGSLIQVPMSEKGKITRGRLGSLSLKKEGERQCFLFSKHLIIC 502


>gi|21735572 epithelial cell transforming sequence 2 oncogene
           protein [Homo sapiens]
          Length = 883

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 70/271 (25%), Positives = 124/271 (45%), Gaps = 12/271 (4%)

Query: 87  KSCQPVTLSGSGTQEPEKK-----IVQELLETEQAYVARLHLLDQVFFQELLKTA-RSSK 140
           KSC     S S T  P K+     + +EL +TE  YV  L  + Q+F   L +   R   
Sbjct: 403 KSC--TKSSKSSTPVPSKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGP 460

Query: 141 AFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFL-KMYSEY 199
               + ++ IF +I  I+  H++    +L+  + +W  +  IGD+  K +  L K Y  +
Sbjct: 461 ILAPEEIKTIFGSIPDIFDVHTKI-KDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPF 519

Query: 200 VKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEY 259
           V  FE + E +     + P F   L   Q+    G  +L   ++ PVQR+P   LLL + 
Sbjct: 520 VNFFEMSKETIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDL 579

Query: 260 IQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDLWE-VYQRLGLEDDIVDPSN 318
            +    + PD++  +KA+  +     H N    + E  + +++ VY+  G   +++    
Sbjct: 580 KKHTADENPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHR 639

Query: 319 TLLREGPVLKISFRRNDPMERY-LFLFNNML 348
           +L++    + +     D  E+  LFLFN+ L
Sbjct: 640 SLVQRVETISLGEHPCDRGEQVTLFLFNDCL 670


>gi|45439359 triple functional domain (PTPRF interacting) [Homo
            sapiens]
          Length = 3097

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 89/376 (23%), Positives = 172/376 (45%), Gaps = 52/376 (13%)

Query: 81   SSEAWRKSCQPVTLSGSGTQEPEKK----------IVQELLETEQAYVARLHLLDQVFFQ 130
            SS ++  S   +  S S   E E++          ++QEL+ETE+ YV  L  + + +  
Sbjct: 1938 SSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMA 1997

Query: 131  ELLKTARSSKAFPEDVV---RVIFSNISSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQ 187
             L+K        P+D+    +++F NI  IY +H  FFL EL++ L+D     ++G +  
Sbjct: 1998 -LMK----EDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLED---PEKLGSLFV 2049

Query: 188  KLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQ 247
            K    L MY  Y +N  ++  +++ + D    F+++  R+        L L   +++PVQ
Sbjct: 2050 KHERRLHMYIAYCQNKPKSEHIVSEYID--TFFEDLKQRL-----GHRLQLTDLLIKPVQ 2102

Query: 248  RIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRL 307
            RI +Y+LLLK++++     + D ++ ++A++++    +  N          D+  V +  
Sbjct: 2103 RIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCN----------DMMNVGRLQ 2152

Query: 308  GLEDDIVDPSNTLLREGPVLKISFRRNDP--MERYLFLFNNMLLYCVPRVIQVGAQ---F 362
            G +  IV     LL++  ++        P   ER +FLF  ++++  P   + G     F
Sbjct: 2153 GFDGKIVAQGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGF 2212

Query: 363  QVRTRIDVAGMKVRELMDAEFPHSFLVSGKQ----RTLELQARSQEEMISWMQAFQAAID 418
              +  I V+ + + E ++ + P  F ++ +      T  L + S     +W+      I+
Sbjct: 2213 LFKNSIKVSCLCLEENVEND-PCKFALTSRTGDVVETFILHSSSPSVRQTWIH----EIN 2267

Query: 419  QIEKRNETFKAAAQGP 434
            QI +    F  A   P
Sbjct: 2268 QILENQRNFLNALTSP 2283



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 85/342 (24%), Positives = 155/342 (45%), Gaps = 46/342 (13%)

Query: 106  IVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVR---VIFSNISSIYQFHS 162
            I+ EL++TE+AYV  L      +  E+          P  +V    +IF N+  IY+FH+
Sbjct: 1296 IMAELIQTEKAYVRDLRECMDTYLWEMTSGVEE---IPPGIVNKELIIFGNMQEIYEFHN 1352

Query: 163  QFFLPELQRRLDDWTANPR-IGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQ 221
              FL EL++    +   P  +G      A   +MY  Y KN   + +L+         F 
Sbjct: 1353 NIFLKELEK----YEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLIL--EHAGSYFD 1406

Query: 222  EVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIF 281
            E+  R   + +  S     ++++PVQRI +Y+LLLKE    L      + + +  L+++ 
Sbjct: 1407 EIQQRHGLANSISS-----YLIKPVQRITKYQLLLKEL---LTCCEEGKGEIKDGLEVML 1458

Query: 282  SAAQHSNAA--ITEMERLQDLWEVYQRLGLED--DIVDPSNTLLREGPVLKISFRRNDPM 337
            S  + +N A  ++ +E   +  E    L L++   + DP  TL+R+G             
Sbjct: 1459 SVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDP-KTLIRKG------------R 1505

Query: 338  ERYLFLFNNMLLYCVPRVIQVG-AQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRT- 395
            ER+LFLF   L++        G +++  ++++  + + V E ++ +     L  G+  T 
Sbjct: 1506 ERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTS 1565

Query: 396  ---LELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGP 434
               + L+A S E    W++  +   + I++R    K A + P
Sbjct: 1566 DNKIVLKASSIENKQDWIKHIR---EVIQERTIHLKGALKEP 1604


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,718,580
Number of Sequences: 37866
Number of extensions: 1206570
Number of successful extensions: 4739
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 123
Number of HSP's successfully gapped in prelim test: 88
Number of HSP's that attempted gapping in prelim test: 4289
Number of HSP's gapped (non-prelim): 296
length of query: 655
length of database: 18,247,518
effective HSP length: 109
effective length of query: 546
effective length of database: 14,120,124
effective search space: 7709587704
effective search space used: 7709587704
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.