Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 188528641
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|188528641 SEC14 and spectrin domains 1 [Homo sapiens]
(696 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|188528641 SEC14 and spectrin domains 1 [Homo sapiens] 1377 0.0
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 229 8e-60
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 229 8e-60
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 221 2e-57
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 122 9e-28
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 122 9e-28
gi|31742505 Rho family guanine-nucleotide exchange factor [Homo ... 86 9e-17
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 80 8e-15
gi|71274186 hypothetical protein LOC85449 [Homo sapiens] 61 4e-09
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 55 3e-07
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 54 4e-07
gi|148529025 pleckstrin homology domain containing, family G (wi... 53 8e-07
gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [... 53 8e-07
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 53 8e-07
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 50 7e-06
gi|50843837 hypothetical protein LOC55701 [Homo sapiens] 49 2e-05
gi|33188443 microfilament and actin filament cross-linker protei... 48 4e-05
gi|33188445 microfilament and actin filament cross-linker protei... 48 4e-05
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 47 8e-05
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 47 8e-05
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 47 8e-05
gi|81295809 pericentrin [Homo sapiens] 45 3e-04
gi|21735548 centrosomal protein 2 [Homo sapiens] 44 5e-04
gi|7705415 hook homolog 1 [Homo sapiens] 43 0.001
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 42 0.001
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 42 0.001
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 42 0.001
gi|118498362 kinectin 1 isoform b [Homo sapiens] 42 0.002
gi|30260188 Golgi autoantigen, golgin subfamily a, 5 [Homo sapiens] 42 0.002
gi|118498356 kinectin 1 isoform a [Homo sapiens] 41 0.003
>gi|188528641 SEC14 and spectrin domains 1 [Homo sapiens]
Length = 696
Score = 1377 bits (3563), Expect = 0.0
Identities = 696/696 (100%), Positives = 696/696 (100%)
Query: 1 MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTNMDELSVTLDYLLSIPSEKCKA 60
MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTNMDELSVTLDYLLSIPSEKCKA
Sbjct: 1 MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTNMDELSVTLDYLLSIPSEKCKA 60
Query: 61 RGFTVIVDGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRL 120
RGFTVIVDGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRL
Sbjct: 61 RGFTVIVDGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRL 120
Query: 121 GFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALI 180
GFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALI
Sbjct: 121 GFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALI 180
Query: 181 NNGSDKGNQQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDE 240
NNGSDKGNQQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDE
Sbjct: 181 NNGSDKGNQQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDE 240
Query: 241 LLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQW 300
LLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQW
Sbjct: 241 LLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQW 300
Query: 301 GIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLS 360
GIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLS
Sbjct: 301 GIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLS 360
Query: 361 DVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLL 420
DVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLL
Sbjct: 361 DVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLL 420
Query: 421 EEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQ 480
EEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQ
Sbjct: 421 EEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQ 480
Query: 481 RCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEK 540
RCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEK
Sbjct: 481 RCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEK 540
Query: 541 HRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHR 600
HRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHR
Sbjct: 541 HRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHR 600
Query: 601 LEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAVGKSLLDRLTVPVVYPDGTEQYFG 660
LEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAVGKSLLDRLTVPVVYPDGTEQYFG
Sbjct: 601 LEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAVGKSLLDRLTVPVVYPDGTEQYFG 660
Query: 661 SPSDMASTAENIRDRMKLVNLKRQQLRHPEMVTTES 696
SPSDMASTAENIRDRMKLVNLKRQQLRHPEMVTTES
Sbjct: 661 SPSDMASTAENIRDRMKLVNLKRQQLRHPEMVTTES 696
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 229 bits (583), Expect = 8e-60
Identities = 173/659 (26%), Positives = 304/659 (46%), Gaps = 34/659 (5%)
Query: 1 MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCL--EQTNMDELSVTLDYLLSIPSEKC 58
++AS +LPILK+K+AF+SGG+D+R G ILT P ++ ++L + YL S+PSE
Sbjct: 30 LKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDV 89
Query: 59 KARGFTVIVDGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKD 118
RGFTVI+D R S+W+++K ++ LQ PAE+ + ++KPD FW K+ T+F
Sbjct: 90 CKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNF----GSS 145
Query: 119 RLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELA 178
+ FE +VS LT+ ++P QLTE+F GSL Y+H +W+ RL E+F + LL L
Sbjct: 146 KFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLE 205
Query: 179 LINNGSDKGNQQEKERSVDL-NFLPSVDPET-----VLQTGHELLSELQQRRF------N 226
+ KE VD+ +D T VL+ E L QR +
Sbjct: 206 DLQE-----MLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSD 260
Query: 227 GSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRT----QLEEIQQKVM 282
G G D P++ LLD L ++ R + QL +Q
Sbjct: 261 GFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAE 320
Query: 283 QVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQ--QIAAL 340
++ +W+ L++ IG S + + LQ +H YV +N+ +A+
Sbjct: 321 KMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMN---AYVNINRIMSVASR 377
Query: 341 LNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGM 400
L+ ++K + QL A+ L+ R +L + FH A+ +D M
Sbjct: 378 LSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKM 437
Query: 401 LCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDV--T 458
P++ ++ + + + V + + G+ LLD + S + + T
Sbjct: 438 CSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTAT 497
Query: 459 IENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLD 518
+ V + V+ ++ ++R E + R++++ Q +QL ++D Q ++W+ +
Sbjct: 498 ANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGE 557
Query: 519 ALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGD 578
A L H +G + L ++H F +VAQ+TY +LL+A L Q+ C
Sbjct: 558 AFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYK 617
Query: 579 TLPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAV 637
L + F E+R L+M+++FH++ +++ + + + ++ D ++AV
Sbjct: 618 AARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAV 676
Score = 77.8 bits (190), Expect = 3e-14
Identities = 104/504 (20%), Positives = 215/504 (42%), Gaps = 51/504 (10%)
Query: 162 VFEKFTKESTSLLDE-----LALINNGS-------DKGNQQEKERSVDLNFLPSVDPETV 209
+FE++T E T+ LD L +N+ + ++ Q+ ER + +N + V
Sbjct: 773 IFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTF----EV 828
Query: 210 LQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRS 269
+Q G +L + + + +G + D +L AQ V +LL+ L E+ + Q
Sbjct: 829 IQQGQDLHQYITEVQASGIE---LICEKDIDLAAQ--VQELLEFLHEKQHELELNAEQTH 883
Query: 270 KRT----QLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSE 325
KR QL +Q +V QV+ W+ G L A S+ ++ LQ++HE+ +
Sbjct: 884 KRLEQCLQLRHLQAEVKQVLGWIRN-GESMLNASLVNASSLSEAEQLQREHEQFQLAIES 942
Query: 326 WFAVY---------VELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNL 376
F +++ Q+ LL AG D ++ ++++ + ++E R L
Sbjct: 943 LFHATSLQKTHQSALQVQQKAEVLLQAG-HYDADAIRECAEKVALHWQQLMLKMEDRLKL 1001
Query: 377 LQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADG-------ASIQQTLKLLEEKLKSVDV 429
+ A++ F+ ++ + L+ L D G A I + L+ + L+ +
Sbjct: 1002 VNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEA 1061
Query: 430 GLQGL---REKGQGLLDQIS-NQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDM 485
L+ R + L I N S V + ++ ++ ++ R+ R
Sbjct: 1062 FLKACTLARRNAEVFLKYIHRNNVSMP---SVASHTRGPEQQVKAILSELLQRENRVLHF 1118
Query: 486 VDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFV 545
+++ ++ Q Q E A QA++W+ E + L TH G+ +ET+ LL+++ +F
Sbjct: 1119 WTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFR 1178
Query: 546 DVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAI 605
A+ T + + L+Q + + + +++ ++ F++ + + LE A+
Sbjct: 1179 VPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKAL 1238
Query: 606 AFHSNAEKILQDCPEEPEAINDEE 629
++ K L + P +++D E
Sbjct: 1239 GVNTEDNKDL-ELDIIPASLSDRE 1261
Score = 74.7 bits (182), Expect = 3e-13
Identities = 77/316 (24%), Positives = 132/316 (41%), Gaps = 37/316 (11%)
Query: 364 YRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEE- 422
Y +E R +L EF A L +L+ L ML P D ++ + +L++E
Sbjct: 178 YNHEEWIELRLSLE----EFFNSAVHLLSRLEDLQEMLARKEFPVD---VEGSRRLIDEH 230
Query: 423 ---KLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDV--TIENKENVDHIQGVMEDMQL 477
K K + ++ L +GQ LL I ++ + + + + V I +++ +
Sbjct: 231 TQLKKKVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHS 290
Query: 478 RKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVL 537
+Q M VR+LK+ Q QL E+DA + +W+S + L++H +G Q L
Sbjct: 291 TRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDL 350
Query: 538 LEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEER 597
+H F + + Y +++ L ++ S+ +L++ WK F A +ER
Sbjct: 351 QTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDER 410
Query: 598 VHRLEMAIAFHSNAEKILQD-------CPEE--PEAINDEE---------------QFDE 633
L M+ FH AE+ L C E P + D E + E
Sbjct: 411 STILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTE 470
Query: 634 IEAVGKSLLDRLTVPV 649
+ GK+LLD L P+
Sbjct: 471 VSQDGKALLDVLQRPL 486
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 229 bits (583), Expect = 8e-60
Identities = 173/659 (26%), Positives = 304/659 (46%), Gaps = 34/659 (5%)
Query: 1 MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCL--EQTNMDELSVTLDYLLSIPSEKC 58
++AS +LPILK+K+AF+SGG+D+R G ILT P ++ ++L + YL S+PSE
Sbjct: 30 LKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDV 89
Query: 59 KARGFTVIVDGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKD 118
RGFTVI+D R S+W+++K ++ LQ PAE+ + ++KPD FW K+ T+F
Sbjct: 90 CKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNF----GSS 145
Query: 119 RLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELA 178
+ FE +VS LT+ ++P QLTE+F GSL Y+H +W+ RL E+F + LL L
Sbjct: 146 KFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLE 205
Query: 179 LINNGSDKGNQQEKERSVDL-NFLPSVDPET-----VLQTGHELLSELQQRRF------N 226
+ KE VD+ +D T VL+ E L QR +
Sbjct: 206 DLQE-----MLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSD 260
Query: 227 GSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRT----QLEEIQQKVM 282
G G D P++ LLD L ++ R + QL +Q
Sbjct: 261 GFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAE 320
Query: 283 QVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQ--QIAAL 340
++ +W+ L++ IG S + + LQ +H YV +N+ +A+
Sbjct: 321 KMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMN---AYVNINRIMSVASR 377
Query: 341 LNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGM 400
L+ ++K + QL A+ L+ R +L + FH A+ +D M
Sbjct: 378 LSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKM 437
Query: 401 LCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDV--T 458
P++ ++ + + + V + + G+ LLD + S + + T
Sbjct: 438 CSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTAT 497
Query: 459 IENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLD 518
+ V + V+ ++ ++R E + R++++ Q +QL ++D Q ++W+ +
Sbjct: 498 ANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGE 557
Query: 519 ALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGD 578
A L H +G + L ++H F +VAQ+TY +LL+A L Q+ C
Sbjct: 558 AFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYK 617
Query: 579 TLPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAV 637
L + F E+R L+M+++FH++ +++ + + + ++ D ++AV
Sbjct: 618 AARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAV 676
Score = 77.8 bits (190), Expect = 3e-14
Identities = 104/504 (20%), Positives = 215/504 (42%), Gaps = 51/504 (10%)
Query: 162 VFEKFTKESTSLLDE-----LALINNGS-------DKGNQQEKERSVDLNFLPSVDPETV 209
+FE++T E T+ LD L +N+ + ++ Q+ ER + +N + V
Sbjct: 773 IFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTF----EV 828
Query: 210 LQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRS 269
+Q G +L + + + +G + D +L AQ V +LL+ L E+ + Q
Sbjct: 829 IQQGQDLHQYITEVQASGIE---LICEKDIDLAAQ--VQELLEFLHEKQHELELNAEQTH 883
Query: 270 KRT----QLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSE 325
KR QL +Q +V QV+ W+ G L A S+ ++ LQ++HE+ +
Sbjct: 884 KRLEQCLQLRHLQAEVKQVLGWIRN-GESMLNASLVNASSLSEAEQLQREHEQFQLAIES 942
Query: 326 WFAVY---------VELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNL 376
F +++ Q+ LL AG D ++ ++++ + ++E R L
Sbjct: 943 LFHATSLQKTHQSALQVQQKAEVLLQAG-HYDADAIRECAEKVALHWQQLMLKMEDRLKL 1001
Query: 377 LQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADG-------ASIQQTLKLLEEKLKSVDV 429
+ A++ F+ ++ + L+ L D G A I + L+ + L+ +
Sbjct: 1002 VNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEA 1061
Query: 430 GLQGL---REKGQGLLDQIS-NQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDM 485
L+ R + L I N S V + ++ ++ ++ R+ R
Sbjct: 1062 FLKACTLARRNAEVFLKYIHRNNVSMP---SVASHTRGPEQQVKAILSELLQRENRVLHF 1118
Query: 486 VDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFV 545
+++ ++ Q Q E A QA++W+ E + L TH G+ +ET+ LL+++ +F
Sbjct: 1119 WTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFR 1178
Query: 546 DVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAI 605
A+ T + + L+Q + + + +++ ++ F++ + + LE A+
Sbjct: 1179 VPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKAL 1238
Query: 606 AFHSNAEKILQDCPEEPEAINDEE 629
++ K L + P +++D E
Sbjct: 1239 GVNTEDNKDL-ELDIIPASLSDRE 1261
Score = 74.7 bits (182), Expect = 3e-13
Identities = 77/316 (24%), Positives = 132/316 (41%), Gaps = 37/316 (11%)
Query: 364 YRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEE- 422
Y +E R +L EF A L +L+ L ML P D ++ + +L++E
Sbjct: 178 YNHEEWIELRLSLE----EFFNSAVHLLSRLEDLQEMLARKEFPVD---VEGSRRLIDEH 230
Query: 423 ---KLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDV--TIENKENVDHIQGVMEDMQL 477
K K + ++ L +GQ LL I ++ + + + + V I +++ +
Sbjct: 231 TQLKKKVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHS 290
Query: 478 RKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVL 537
+Q M VR+LK+ Q QL E+DA + +W+S + L++H +G Q L
Sbjct: 291 TRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDL 350
Query: 538 LEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEER 597
+H F + + Y +++ L ++ S+ +L++ WK F A +ER
Sbjct: 351 QTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDER 410
Query: 598 VHRLEMAIAFHSNAEKILQD-------CPEE--PEAINDEE---------------QFDE 633
L M+ FH AE+ L C E P + D E + E
Sbjct: 411 STILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTE 470
Query: 634 IEAVGKSLLDRLTVPV 649
+ GK+LLD L P+
Sbjct: 471 VSQDGKALLDVLQRPL 486
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 221 bits (563), Expect = 2e-57
Identities = 167/659 (25%), Positives = 308/659 (46%), Gaps = 34/659 (5%)
Query: 1 MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCL--EQTNMDELSVTLDYLLSIPSEKC 58
M+A +LPILK+K+A+LSGG+D+R G ILT P ++ ++L + YL IPSE+
Sbjct: 60 MKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEV 119
Query: 59 KARGFTVIVDGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKD 118
RGFTVIVD R S+W+ +K ++ +LQ P + + ++KPD FW K+ T+F
Sbjct: 120 CKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNF----GSS 175
Query: 119 RLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELA 178
+ FE +VS LT+ ++P QLT +F G L Y+H +W+ R+ FE + +T +L L
Sbjct: 176 KFEFETNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLE 235
Query: 179 LINNGSDKG----------NQQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRR-FNG 227
+ + K N E+ + + + + L+ G +LL +Q F
Sbjct: 236 ELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLE-GQKLLQRIQSSESFPK 294
Query: 228 SDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRT----QLEEIQQKVMQ 283
+ G + + + L P+V +LD L ++ R + QL +Q +
Sbjct: 295 KNSGSGNADLQNLL---PKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEK 351
Query: 284 VVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQ--QIAALL 341
+ +W+ L + IG S + LQ +H VYV +N+ +A L
Sbjct: 352 MFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMN---VYVNINRIMSVANRL 408
Query: 342 NAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGML 401
+++ + QL A+ L+ R LL + FH A+ +D
Sbjct: 409 VESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWC-KA 467
Query: 402 CVDV-APADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIE 460
C +V P++ ++ + + + + + + + G+ LLD++ + +T
Sbjct: 468 CGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTAS 527
Query: 461 NKEN--VDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLD 518
+ V H+ V+ ++ +++ E++ R++++ Q +QL ++D Q ++W+ +
Sbjct: 528 ANYSKAVHHVLDVIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGE 587
Query: 519 ALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGD 578
A L H +G + L ++H F +VAQ+TY +LL+A L Q+ C
Sbjct: 588 AFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQ 647
Query: 579 TLPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAV 637
+L + F E+R L+M+++FH++ +++ E + + D+ + +EAV
Sbjct: 648 AAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAV 706
Score = 90.5 bits (223), Expect = 5e-18
Identities = 99/425 (23%), Positives = 187/425 (44%), Gaps = 31/425 (7%)
Query: 209 VLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQR 268
V Q G LL +LQ+ GS ++ S + A V+ ++ + + + + + R
Sbjct: 501 VSQDGKSLLDKLQRPLTPGSSDSLTASANYSK--AVHHVLDVIHEVLHHQRQLENIWQHR 558
Query: 269 S----KRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHS 324
+R QL QQ V QV++W+E G L G+G S+ ++ALQ++HE+ E
Sbjct: 559 KVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQ 618
Query: 325 EWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFH 384
+ +L + L G E D E+ QL D ++E R+ LL ++ FH
Sbjct: 619 NTYTNADKLLEAAEQLAQTG-ECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFH 677
Query: 385 GVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQ 444
++L L+ L L DV ++Q +K ++ ++ + ++G+ L+ Q
Sbjct: 678 THVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTTLQVTVNVIKEGEDLIQQ 737
Query: 445 ISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEE 504
+ + A + T N +++HI+ V++ + + + E++ R++K+ +QL E
Sbjct: 738 LRDSA---ISSNKTPHNS-SINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFER 793
Query: 505 DAAQAVEWLSELLDALLKTHIRLGD-DAQETKVLLEKHRKFVDVAQS----TYD---YGR 556
DA + L D L + ++ D D ++ + ++ + D A + T+D G+
Sbjct: 794 DAIDIISDLESWNDELSQ---QMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQ 850
Query: 557 QLLQ--------ATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAIAF- 607
LLQ +LC + D L L+ ++ +A+E+ LE +
Sbjct: 851 DLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLR 910
Query: 608 HSNAE 612
H AE
Sbjct: 911 HLQAE 915
Score = 84.3 bits (207), Expect = 3e-16
Identities = 84/420 (20%), Positives = 181/420 (43%), Gaps = 25/420 (5%)
Query: 209 VLQTGHELLSELQQRRFNG----SDGGVSWSPMDDELLA-QPQVMKLLDSLREQYTRYQE 263
V+ G +LL + + + +G D V + +LL + + LD EQ+ ++ E
Sbjct: 845 VIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHRKHLE 904
Query: 264 VCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQH 323
C QL +Q +V QV+ W+ G L A S++ ++ LQ++HE+ +
Sbjct: 905 QC------VQLRHLQAEVKQVLGWIRN-GESMLNAGLITASSLQEAEQLQREHEQFQHAI 957
Query: 324 SEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEF 383
+ +++ Q+ A+L A + D+ ++ ++++ + ++E R L+ A++ F
Sbjct: 958 EKTHQSALQVQQKAEAMLQA-NHYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAF 1016
Query: 384 HGVAQDLSQQLDGLLGMLCVDVAPADGAS-------IQQTLKLLEEKLKSVDVGLQGL-- 434
+ ++ + L+ L + GA ++ + L+ + L+
Sbjct: 1017 YKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTL 1076
Query: 435 -REKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKM 493
R L + + G I+ E ++ ++ ++ R+ R +R+ ++
Sbjct: 1077 ARRNADVFLKYLHRNSVNMPGMVTHIKAPEQ--QVKNILNELFQRENRVLHYWTMRKRRL 1134
Query: 494 LQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYD 553
Q Q E A QA+EW+ + + L TH G Q T+ LL++H +F A+ T +
Sbjct: 1135 DQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHEEFQITAKQTKE 1194
Query: 554 YGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEK 613
+ L+Q C+ + + +++ ++ F++ E+ LE A+ S++ K
Sbjct: 1195 RVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNK 1254
Score = 73.2 bits (178), Expect = 8e-13
Identities = 73/334 (21%), Positives = 139/334 (41%), Gaps = 39/334 (11%)
Query: 387 AQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEE----KLKSVDVGLQGLREKGQGLL 442
A + +L+ L +L P D ++ ++EE K K + ++ L +GQ LL
Sbjct: 227 ATHMLSRLEELQDILAKKELPQD---LEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLL 283
Query: 443 DQISNQASWAYGKDVTIENKENVDH----IQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQ 498
+I Q+S ++ K + ++ + + +++ + +Q M VR+LK+ Q Q
Sbjct: 284 QRI--QSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQ 341
Query: 499 LFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQL 558
L E+DA + +W++ L ++ +G L +H F + Y ++
Sbjct: 342 LRLFEQDAEKMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRI 401
Query: 559 LQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQ-- 616
+ L +S S+ +L + WK F A +ER L+M+ FH AEK +
Sbjct: 402 MSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNV 461
Query: 617 ----------DCPEEPEAINDEEQ------------FDEIEAVGKSLLDRLTVPVVYPDG 654
D P E + + D + E+ GKSLLD+L P+ G
Sbjct: 462 DSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLT--PG 519
Query: 655 TEQYFGSPSDMASTAENIRDRMKLVNLKRQQLRH 688
+ + ++ + ++ D + V ++QL +
Sbjct: 520 SSDSLTASANYSKAVHHVLDVIHEVLHHQRQLEN 553
Score = 53.5 bits (127), Expect = 6e-07
Identities = 53/278 (19%), Positives = 119/278 (42%), Gaps = 21/278 (7%)
Query: 346 EEDLVELKSLQQQLSDVCYRQASQLE-------FRQNLLQAALEFHGVAQDLSQQLDGLL 398
E L +L Q Q+ ++ + +LE F ++ + + +LSQQ++
Sbjct: 758 ETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELSQQMN--- 814
Query: 399 GMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISN-QASWAYGKDV 457
D D +Q L+ +K +++ + +GQ LL ++ QAS G ++
Sbjct: 815 -----DFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQAS---GVEL 866
Query: 458 TIENKENV-DHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSEL 516
+ ++ +Q ++E + ++Q + + R + Q VQL + + Q + W+
Sbjct: 867 LCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQAEVKQVLGWIRNG 926
Query: 517 LDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSS 576
+++L + QE + L +H +F + T+ Q+ Q + Q+
Sbjct: 927 -ESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMI 985
Query: 577 GDTLPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKI 614
D ++ W+Q + E+R+ + ++AF+ +E++
Sbjct: 986 RDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQV 1023
Score = 35.0 bits (79), Expect = 0.23
Identities = 50/195 (25%), Positives = 84/195 (43%), Gaps = 23/195 (11%)
Query: 244 QPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVM------QVVNWLEGPGSEQLR 297
+ QV +L+ L ++ R R +R L++ QQ V+ Q + W+ G L
Sbjct: 1106 EQQVKNILNELFQRENRVLHYWTMRKRR--LDQCQQYVVFERSAKQALEWIHDNGEFYLS 1163
Query: 298 AQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQ 357
G SI+ +Q L ++HEE + ++ V+L Q+A E+K
Sbjct: 1164 THTSTGSSIQHTQELLKEHEEFQIT-AKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVT 1222
Query: 358 QLSDVCYRQAS-QLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQT 416
+ D YR S ++E + L+ AL G++ D ++ L +D+ PA +
Sbjct: 1223 AV-DKRYRDFSLRMEKYRTSLEKAL---GISSDSNKSSKSLQ----LDIIPASIPGSEVK 1274
Query: 417 LK-----LLEEKLKS 426
L+ L EEK KS
Sbjct: 1275 LRDAAHELNEEKRKS 1289
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 122 bits (307), Expect = 9e-28
Identities = 130/519 (25%), Positives = 227/519 (43%), Gaps = 57/519 (10%)
Query: 10 LKKKLAFLSGGKDRRSGLILTIP--LCLEQTNMDELSVTLDYLLSIPSEKCKARGFTVIV 67
LKK+ A+LSGG+ + ++T P + E + YL SIPS + GF +++
Sbjct: 103 LKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVI 162
Query: 68 DGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEV--- 124
D R+ +W VK V+ + PA + LV V++P F+ + ++ F +D +V
Sbjct: 163 DRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVI 222
Query: 125 ILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKF---TKESTSLLDELALIN 181
+L S L YI+ QLTED GG+L Y H WL +R E F K++ +L
Sbjct: 223 MLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTEL 282
Query: 182 NGSDKGNQQEKERSV-----DLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSP 236
++ N + SV + D L+ GH +L L++ + GS+ V+
Sbjct: 283 AETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVN--- 339
Query: 237 MDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKR----TQLEEIQQKVMQVVNWLEGPG 292
D+L Q V +LL L E + E + ++ QL +Q +V L+
Sbjct: 340 -QDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDA-A 397
Query: 293 SEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLV-- 350
S+++ IG+S+ + L + E E V VE + ++ D E L+
Sbjct: 398 SQKIATFTDIGNSLAHVEHLLRDLASFE----EKSGVAVERARALSL-----DGEQLIGN 448
Query: 351 ------ELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDG---LLGML 401
++ Q+L +C + ++++ R+ LL +LE H + + D LL
Sbjct: 449 KHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQ 508
Query: 402 CVDVAPA-DG--ASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVT 458
VD + DG A++Q+ K LE ++ L + ++ + +L+Q
Sbjct: 509 PVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQ------------DL 556
Query: 459 IENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMV 497
+E+ V Q ME++ R+Q + R+ + +Q V
Sbjct: 557 MEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPV 595
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 122 bits (307), Expect = 9e-28
Identities = 130/519 (25%), Positives = 227/519 (43%), Gaps = 57/519 (10%)
Query: 10 LKKKLAFLSGGKDRRSGLILTIP--LCLEQTNMDELSVTLDYLLSIPSEKCKARGFTVIV 67
LKK+ A+LSGG+ + ++T P + E + YL SIPS + GF +++
Sbjct: 50 LKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVI 109
Query: 68 DGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEV--- 124
D R+ +W VK V+ + PA + LV V++P F+ + ++ F +D +V
Sbjct: 110 DRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVI 169
Query: 125 ILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKF---TKESTSLLDELALIN 181
+L S L YI+ QLTED GG+L Y H WL +R E F K++ +L
Sbjct: 170 MLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTEL 229
Query: 182 NGSDKGNQQEKERSV-----DLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSP 236
++ N + SV + D L+ GH +L L++ + GS+ V+
Sbjct: 230 AETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVN--- 286
Query: 237 MDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKR----TQLEEIQQKVMQVVNWLEGPG 292
D+L Q V +LL L E + E + ++ QL +Q +V L+
Sbjct: 287 -QDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDA-A 344
Query: 293 SEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLV-- 350
S+++ IG+S+ + L + E E V VE + ++ D E L+
Sbjct: 345 SQKIATFTDIGNSLAHVEHLLRDLASFE----EKSGVAVERARALSL-----DGEQLIGN 395
Query: 351 ------ELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDG---LLGML 401
++ Q+L +C + ++++ R+ LL +LE H + + D LL
Sbjct: 396 KHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQ 455
Query: 402 CVDVAPA-DG--ASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVT 458
VD + DG A++Q+ K LE ++ L + ++ + +L+Q
Sbjct: 456 PVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQ------------DL 503
Query: 459 IENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMV 497
+E+ V Q ME++ R+Q + R+ + +Q V
Sbjct: 504 MEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPV 542
>gi|31742505 Rho family guanine-nucleotide exchange factor [Homo
sapiens]
Length = 1114
Score = 86.3 bits (212), Expect = 9e-17
Identities = 96/447 (21%), Positives = 190/447 (42%), Gaps = 45/447 (10%)
Query: 6 ILPILKKKLAFLSGGKDRRSGLILTIPLC--LEQTNMDELSVTLDYLLSIPSEKCKARGF 63
I+ L ++ A LSGG+ I+T P + ++ + YL SIPS + + GF
Sbjct: 41 IIEQLHRQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGF 100
Query: 64 TVIVDGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTH--FCFWKEKDRLG 121
V++D R+ +W+ VK + + P + L+ +++P F + T +++ + +
Sbjct: 101 IVVIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTK 160
Query: 122 FEVILV-SANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALI 180
+I+V S + L YI+ QLT + GG+L Y H W+N R E F + L
Sbjct: 161 VPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQTF 220
Query: 181 NNGSDKGNQQEKERSVDLNFLPSVDPETVLQ--------TGHELLSELQQRRFNGSDGGV 232
+ S + + LQ G LLS +Q+ + +
Sbjct: 221 GSCLATAELPRSMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKL 280
Query: 233 SWSPMDDELLAQPQVMKLLDSLREQYTRY-QEVCRQRSKRTQLEEIQQKVMQVVNWLEGP 291
+ + +++ + +++ LD + ++ + E + ++ QL+ + + L+
Sbjct: 281 NLNQLEN-VTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNL 339
Query: 292 GSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDE----- 346
EQ GIGDS+ + + ++H+++E + E Q+ AL+ GD+
Sbjct: 340 LEEQAEFT-GIGDSVMHVEQILKEHKKLEEKSQEPLE-----KAQLLALV--GDQLIQSH 391
Query: 347 ---EDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLC- 402
D + + + +L +C + + + ++L +LEFH +SQ + + +L
Sbjct: 392 HYAADAIRPRCV--ELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWCEAGIYLLAS 449
Query: 403 -----------VDVAPADGASIQQTLK 418
VD+A D A+ T+K
Sbjct: 450 QAVDKCQSREGVDIALNDIATFLGTVK 476
Score = 43.9 bits (102), Expect = 5e-04
Identities = 54/278 (19%), Positives = 103/278 (37%), Gaps = 6/278 (2%)
Query: 342 NAGDEEDLVELKSLQQQLSDVC-YRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGM 400
+ D ++ L ++L YR + R + AL AQ L
Sbjct: 168 SVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQ----MLQTFGSC 223
Query: 401 LCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIE 460
L P S + L + + L+ L ++G LL I A+ + +
Sbjct: 224 LATAELPRSMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLN 283
Query: 461 NKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDAL 520
ENV ++ ++ + ++ LK+ Q +QL E D +A L LL+
Sbjct: 284 QLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQ 343
Query: 521 LKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTL 580
+ +GD + +L++H+K + +Q + + L L QS + +
Sbjct: 344 AE-FTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRC 402
Query: 581 PRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQDC 618
L + F ++++ L ++ FH +K+ Q C
Sbjct: 403 VELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWC 440
>gi|153791628 MCF.2 cell line derived transforming sequence isoform
a [Homo sapiens]
Length = 985
Score = 79.7 bits (195), Expect = 8e-15
Identities = 53/172 (30%), Positives = 83/172 (48%), Gaps = 14/172 (8%)
Query: 14 LAFLSGGKDRRSGLILTIPLCLEQTNM-----DELSVTLDYLLSIPSEKCKARGFTVIVD 68
+AFLSGG+ + + I+T P E N + ++ L YL SI + FT+I+D
Sbjct: 4 IAFLSGGRGKDNAWIITFP---ENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTIILD 60
Query: 69 GRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFE---VI 125
R W+ +K + + P + LV V++P F + T FW ++ + V+
Sbjct: 61 RRLDTWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVM 120
Query: 126 LVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKF---TKESTSLL 174
L S + L YI+ QLT + GG+L Y H +W+ R E F KE +L
Sbjct: 121 LSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQML 172
Score = 34.7 bits (78), Expect = 0.31
Identities = 83/381 (21%), Positives = 158/381 (41%), Gaps = 49/381 (12%)
Query: 333 LNQQIAALLNAGDEEDLVELKSLQQQLSDVC-YRQASQLEFRQNLLQAALEFHGVAQDLS 391
L + L + D ++ K L +L Y + + FR + AL ++++
Sbjct: 114 LKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFAL----TVKEMA 169
Query: 392 QQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQIS-NQAS 450
Q L L P D SI++ L + E+ + + + ++G+ LL +
Sbjct: 170 QMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTE 229
Query: 451 WAYGKDVTIENKENVDH--IQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQ 508
A + + + D I ++ + + + + +LKM Q +QL+K E+D Q
Sbjct: 230 GAVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQ 289
Query: 509 AVEWLSELLDALLKTHIRLGDDAQ------ETKVLLEKHRKFVDVAQSTYDYGRQLL--- 559
V + LL+ + G AQ + + L E ++ + AQ +G +L
Sbjct: 290 LVTEVEFLLNQQAELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANH 349
Query: 560 -QATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQ-- 616
A ++CQ RC + L L+ + + +E + R++++ F K+LQ
Sbjct: 350 HYALDLICQ--RC------NELRYLSDI-----LVNEIKAKRIQLSRTF--KMHKLLQQA 394
Query: 617 -DCPEEPEAI--NDE-EQFDEIEAVGKSLLD-----RLTVPVV-YPDGTEQYFGSPSDMA 666
C +E E + N E ++F E K+L D + +P + Y T QY D+
Sbjct: 395 RQCCDEGECLLANQEIDKFQSKEDAQKALQDIENFLEMALPFINYEPETLQY---EFDVI 451
Query: 667 STAENIRDRMKLVNLKRQQLR 687
+ E ++ +MK + LK + +R
Sbjct: 452 LSPE-LKVQMKTIQLKLENIR 471
>gi|71274186 hypothetical protein LOC85449 [Homo sapiens]
Length = 1200
Score = 60.8 bits (146), Expect = 4e-09
Identities = 107/479 (22%), Positives = 189/479 (39%), Gaps = 68/479 (14%)
Query: 9 ILKKKLAFLSGGKDRRSGLILTI---------PLCLEQTNMDELSVTLDYLLSIPSEKCK 59
+ + ++A L GG+DR +L + P C + E++ L YL +IP + K
Sbjct: 573 VFRSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWC----TVSEVTKLLSYLCTIPRPEDK 628
Query: 60 ARGFTVIVDGRKS--QWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEK 117
A+G V++D R+ Q +V + + Q VPA + + + E + T E
Sbjct: 629 AKGLAVLIDARRQPPQPGLV-SALQATQAQVPASIRAILFLGEKEAALQLQTLPDVQVE- 686
Query: 118 DRLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKE----STSL 173
+L S L+ +++P QL G Y H +W++ + F + S+ L
Sbjct: 687 -------VLTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLL 739
Query: 174 LDELALINNGSDKGNQQEKER----SVDLNFLPSVDPET--VLQTGHELLSELQQRRFNG 227
+ G QE R S +L DP + + G L+ LQ
Sbjct: 740 QASIEEFEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGATLARLQH----- 794
Query: 228 SDGGVSWSP-MDDELLAQPQVMKLLD-SLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVV 285
+ +SP + L A + L+D L T + + R +L ++ + QV
Sbjct: 795 DASRLDFSPDVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQVS 854
Query: 286 NWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVY---VELNQQIAAL-- 340
+W+E G L++ S+ + +++ H E E+ + A Y +EL++Q A L
Sbjct: 855 DWMEQEGRRCLQSLTPKDGSL---ETVEKAHAEFENFFLQAAAQYRRGLELSKQAAQLGA 911
Query: 341 --LNAGDEE-----DLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLS-- 391
AG+ E +L S Q+ E ++ L+ L H + ++
Sbjct: 912 TARGAGEAERAEFPELAAFASTQRAFQAELTHFYMAAERQRTDLETLLHLHRFCKRMTWF 971
Query: 392 -QQLDGLLGMLCVD----VAPADGASIQQTLKLL-----EEKLKSVDVGLQGLREKGQG 440
L+ L +D V+P D + + L+ L EKL +V + + L G G
Sbjct: 972 HMDCQDLMAQLRLDKTSRVSPGDQRRLHRYLQRLASEFPAEKLAAVGLQVASLSRAGLG 1030
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 54.7 bits (130), Expect = 3e-07
Identities = 88/409 (21%), Positives = 157/409 (38%), Gaps = 38/409 (9%)
Query: 251 LDSLREQYTRYQEVCRQRSKRT----QLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSI 306
+ L E++ Q++ +RS+ +++ + + W+E Q G +
Sbjct: 1208 IKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEE--KNQALNTDNYGHDL 1265
Query: 307 RASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDE--EDLVELKSLQQQLSDVCY 364
+ QALQ+KHE E + L + L+ + E EDL E + Q
Sbjct: 1266 ASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLG 1325
Query: 365 RQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKL 424
++A Q + + F +DL ++G+ G++ D D + L+ +E
Sbjct: 1326 KRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHR 1385
Query: 425 KSVDV---GLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQR 481
+D Q + GQ LL A+G + E K+ +D + D+
Sbjct: 1386 TEIDARAGTFQAFEQFGQQLL---------AHGHYASPEIKQKLDILDQERADL------ 1430
Query: 482 CEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKH 541
E RR+ + Q ++L D QA W++ +A L T + GD + L++KH
Sbjct: 1431 -EKAWVQRRMMLDQCLELQLFHRDCEQAENWMA-AREAFLNTEDK-GDSLDSVEALIKKH 1487
Query: 542 RKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRV---WKQFTIASEERV 598
F D A + + LQA Q + + GD R N V W++ E+
Sbjct: 1488 EDF-DKAINVQEEKIAALQA--FADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKR 1544
Query: 599 HRL---EMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAVGKSLLDR 644
+L + F + ++I E+ + +DE D LL +
Sbjct: 1545 SKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSK 1593
Score = 53.5 bits (127), Expect = 6e-07
Identities = 93/432 (21%), Positives = 175/432 (40%), Gaps = 77/432 (17%)
Query: 126 LVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALINNGSD 185
L+ A KL +Y+ C+ D MDW+N KE+ +EL G D
Sbjct: 145 LLQAQKLVQYLRECE-----------DVMDWIND--------KEAIVTSEEL-----GQD 180
Query: 186 KGNQQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQP 245
+ + ++ + + +T + E ++E+ Q + ++EL+
Sbjct: 181 LEHVEVLQKKFE-------EFQTDMAAHEERVNEVNQFAAKL----IQEQHPEEELIKTK 229
Query: 246 QVMKLLDSLREQYTRYQEVCRQRSKR----TQLEEIQQKVMQVVNWLEGPGSEQLRAQWG 301
Q D + + R + + QR + +++ + V + ++W++ EQL A
Sbjct: 230 Q-----DEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKE--KEQLMASDD 282
Query: 302 IGDSIRASQALQQKHEEIE----SQHSEWFAVYVELN--QQIAALLNAGDEEDLVELKSL 355
G + + QAL +KHE +E + + A+ E + QQ L + EL +
Sbjct: 283 FGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITN 342
Query: 356 QQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQ 415
+Q+ + + ++L L + +F +DL+ + + ++ D +D A +
Sbjct: 343 WEQIRTLAAERHARLNDSYRLQRFLADF----RDLTSWVTEMKALINADELASDVAGAEA 398
Query: 416 TLKLLEEKLKSVDV---GLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVM 472
L +E +D + E GQ LL + AS + +T+ ++E ++
Sbjct: 399 LLDRHQEHKGEIDAHEDSFKSADESGQALL-AAGHYASDEVREKLTVLSEERA----ALL 453
Query: 473 EDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQ 532
E +LR+Q+ E +D +QLF D Q W+S+ LL LGD
Sbjct: 454 ELWELRRQQYEQCMD---------LQLF--YRDTEQVDNWMSKQEAFLLNED--LGDSLD 500
Query: 533 ETKVLLEKHRKF 544
+ LL+KH F
Sbjct: 501 SVEALLKKHEDF 512
Score = 46.2 bits (108), Expect = 1e-04
Identities = 80/399 (20%), Positives = 153/399 (38%), Gaps = 22/399 (5%)
Query: 238 DDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLE-EIQQKVMQVVN---WLEGPGS 293
DD + + ++ + L E + +++ R +R + E QQ V V W+ +
Sbjct: 1837 DDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMT 1896
Query: 294 EQLRAQWGIGDSIRASQALQQKHEEIESQ---HSEWFAVYVELNQQIAALLNAGDEEDLV 350
L A GD++ A Q L +KHE E+ H + Q + N +E
Sbjct: 1897 --LVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISS 1954
Query: 351 ELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADG 410
++K L ++SD+ + A+Q + + + A L+F+ A + + L D D
Sbjct: 1955 KMKGLNGKVSDL-EKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDL 2013
Query: 411 ASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQ---ASWAYGKDVTIENKENVDH 467
+S+Q L K ++ D GLQ +++G + + +Q A K + + +
Sbjct: 2014 SSVQTLL----TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKR 2069
Query: 468 IQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRL 527
++ + RK++ + R ++ LF A A E + L +R
Sbjct: 2070 WSQLLANSAARKKKLLEAQSHFR----KVEDLFLTFAKKASAFNSWFENAEEDLTDPVRC 2125
Query: 528 GDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVW 587
+ +E K L E H F S QL + + ++ + T+ L W
Sbjct: 2126 -NSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETW 2184
Query: 588 KQFTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAIN 626
+ +ER L+ +K+ Q+ + A +
Sbjct: 2185 RNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFH 2223
Score = 40.0 bits (92), Expect = 0.007
Identities = 74/369 (20%), Positives = 146/369 (39%), Gaps = 37/369 (10%)
Query: 243 AQPQVMKLLDSLREQYTRYQEVCRQRS-KRTQLEEIQQKVMQ---VVNWLEGPGSEQLRA 298
A + L L Q+ E R++ K Q +++ Q + + V++W+ E +
Sbjct: 116 ASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWIND--KEAIVT 173
Query: 299 QWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALL-NAGDEEDLVELKSLQQ 357
+G + + LQ+K EE ++ + E+NQ A L+ EE+L++ K Q
Sbjct: 174 SEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTK--QD 231
Query: 358 QLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLL---GMLCVDVAPADGASIQ 414
+++ R RQ L A E +D+ + + + ++ D D AS+Q
Sbjct: 232 EVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQ 291
Query: 415 QTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMED 474
L+ K + ++ L L +K + L A + + + IQ E+
Sbjct: 292 ALLR----KHEGLERDLAALEDKVKALC---------AEADRLQQSHPLSATQIQVKREE 338
Query: 475 MQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQET 534
+ ++ + R ++ +L + D W++E + AL+ L D
Sbjct: 339 LITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTE-MKALINAD-ELASDVAGA 396
Query: 535 KVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIAS 594
+ LL++H++ + D ++ Q+L + D V ++ T+ S
Sbjct: 397 EALLDRHQEH----KGEIDAHEDSFKSADESGQALLAAGHYASD------EVREKLTVLS 446
Query: 595 EERVHRLEM 603
EER LE+
Sbjct: 447 EERAALLEL 455
Score = 37.4 bits (85), Expect = 0.047
Identities = 57/276 (20%), Positives = 107/276 (38%), Gaps = 28/276 (10%)
Query: 339 ALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLL 398
+LL G++ + KS ++ + +R+A++L+ N +AAL V DL Q
Sbjct: 1075 SLLELGEKRKGMLEKSCKKFM---LFREANELQQWINEKEAALTSEEVGADLEQ------ 1125
Query: 399 GMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYG---K 455
V+V Q+ LK E +LK ++ + L +G + + Q YG +
Sbjct: 1126 ----VEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPR 1181
Query: 456 DVTIENKENVDHIQGVM----------EDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEED 505
D T + +M +++ R + + + + R + ++ + D
Sbjct: 1182 DETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRD 1241
Query: 506 AAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVL 565
A + EW+ E AL + G D + L KH F + D L + L
Sbjct: 1242 ADETKEWIEEKNQALNTDN--YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERL 1299
Query: 566 CQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRL 601
QS ++ + LN+ W +++R +L
Sbjct: 1300 IQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKL 1335
Score = 37.0 bits (84), Expect = 0.062
Identities = 48/228 (21%), Positives = 94/228 (41%), Gaps = 15/228 (6%)
Query: 463 ENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLK 522
E + IQ + + R R +++ +RR K+ + + DA + +W+ E L
Sbjct: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASD 69
Query: 523 THIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPR 582
+ + D + L+KH+ F Q+ +L + ++ S + L
Sbjct: 70 ENYK---DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLME 126
Query: 583 LNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAVGKSLL 642
L+R W+ E+ +L A + L++C + + IND+E E +G+ L
Sbjct: 127 LHRQWELLLEKMREKGIKLLQA----QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLE 182
Query: 643 DRLTVPVVYPDGTEQYFGSPSDMASTAENIRDRMKLVNLKRQQLRHPE 690
V V+ +++ +DMA+ E + + + K Q +HPE
Sbjct: 183 H---VEVL----QKKFEEFQTDMAAHEERVNE-VNQFAAKLIQEQHPE 222
Score = 32.7 bits (73), Expect = 1.2
Identities = 52/222 (23%), Positives = 89/222 (40%), Gaps = 36/222 (16%)
Query: 243 AQPQVMKLLDSLREQYTRYQEVCRQRSKRTQ----LEEIQQKVMQVVNWLEGPGSEQLRA 298
A +V + L L E+ E+ R ++ + L+ + QV NW+ E
Sbjct: 434 ASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK--QEAFLL 491
Query: 299 QWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQ 358
+GDS+ + +AL +KHE+ E S ++I AL DE +++
Sbjct: 492 NEDLGDSLDSVEALLKKHEDFEKSLS-------AQEEKITAL----DEFATKLIQNNHYA 540
Query: 359 LSDVCYRQASQLEFRQNLLQAAL--------EFHGVAQDLSQQLDGLLGML------CVD 404
+ DV R+ + L R L + A+ FH Q + D L + D
Sbjct: 541 MEDVATRRDALLSRRNALHERAMRRRAQLADSFH--LQQFFRDSDELKSWVNEKMKTATD 598
Query: 405 VAPADGASIQ---QTLKLLEEKLKSVDVGLQGLREKGQGLLD 443
A D +++Q Q + E +L + + L + GQ L+D
Sbjct: 599 EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLID 640
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 54.3 bits (129), Expect = 4e-07
Identities = 86/397 (21%), Positives = 154/397 (38%), Gaps = 38/397 (9%)
Query: 251 LDSLREQYTRYQEVCRQRSKRT----QLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSI 306
+ L E++ Q++ +RS+ +++ + + W+E Q G +
Sbjct: 1208 IKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEE--KNQALNTDNYGHDL 1265
Query: 307 RASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDE--EDLVELKSLQQQLSDVCY 364
+ QALQ+KHE E + L + L+ + E EDL E + Q
Sbjct: 1266 ASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLG 1325
Query: 365 RQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKL 424
++A Q + + F +DL ++G+ G++ D D + L+ +E
Sbjct: 1326 KRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHR 1385
Query: 425 KSVDV---GLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQR 481
+D Q + GQ LL A+G + E K+ +D + D+
Sbjct: 1386 TEIDARAGTFQAFEQFGQQLL---------AHGHYASPEIKQKLDILDQERADL------ 1430
Query: 482 CEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKH 541
E RR+ + Q ++L D QA W++ +A L T + GD + L++KH
Sbjct: 1431 -EKAWVQRRMMLDQCLELQLFHRDCEQAENWMA-AREAFLNTEDK-GDSLDSVEALIKKH 1487
Query: 542 RKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRV---WKQFTIASEERV 598
F D A + + LQA Q + + GD R N V W++ E+
Sbjct: 1488 EDF-DKAINVQEEKIAALQA--FADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKR 1544
Query: 599 HRL---EMAIAFHSNAEKILQDCPEEPEAINDEEQFD 632
+L + F + ++I E+ + +DE D
Sbjct: 1545 SKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKD 1581
Score = 53.5 bits (127), Expect = 6e-07
Identities = 93/432 (21%), Positives = 175/432 (40%), Gaps = 77/432 (17%)
Query: 126 LVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALINNGSD 185
L+ A KL +Y+ C+ D MDW+N KE+ +EL G D
Sbjct: 145 LLQAQKLVQYLRECE-----------DVMDWIND--------KEAIVTSEEL-----GQD 180
Query: 186 KGNQQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQP 245
+ + ++ + + +T + E ++E+ Q + ++EL+
Sbjct: 181 LEHVEVLQKKFE-------EFQTDMAAHEERVNEVNQFAAKL----IQEQHPEEELIKTK 229
Query: 246 QVMKLLDSLREQYTRYQEVCRQRSKR----TQLEEIQQKVMQVVNWLEGPGSEQLRAQWG 301
Q D + + R + + QR + +++ + V + ++W++ EQL A
Sbjct: 230 Q-----DEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKE--KEQLMASDD 282
Query: 302 IGDSIRASQALQQKHEEIE----SQHSEWFAVYVELN--QQIAALLNAGDEEDLVELKSL 355
G + + QAL +KHE +E + + A+ E + QQ L + EL +
Sbjct: 283 FGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITN 342
Query: 356 QQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQ 415
+Q+ + + ++L L + +F +DL+ + + ++ D +D A +
Sbjct: 343 WEQIRTLAAERHARLNDSYRLQRFLADF----RDLTSWVTEMKALINADELASDVAGAEA 398
Query: 416 TLKLLEEKLKSVDV---GLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVM 472
L +E +D + E GQ LL + AS + +T+ ++E ++
Sbjct: 399 LLDRHQEHKGEIDAHEDSFKSADESGQALL-AAGHYASDEVREKLTVLSEERA----ALL 453
Query: 473 EDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQ 532
E +LR+Q+ E +D +QLF D Q W+S+ LL LGD
Sbjct: 454 ELWELRRQQYEQCMD---------LQLF--YRDTEQVDNWMSKQEAFLLNED--LGDSLD 500
Query: 533 ETKVLLEKHRKF 544
+ LL+KH F
Sbjct: 501 SVEALLKKHEDF 512
Score = 46.2 bits (108), Expect = 1e-04
Identities = 80/399 (20%), Positives = 153/399 (38%), Gaps = 22/399 (5%)
Query: 238 DDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLE-EIQQKVMQVVN---WLEGPGS 293
DD + + ++ + L E + +++ R +R + E QQ V V W+ +
Sbjct: 1832 DDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMT 1891
Query: 294 EQLRAQWGIGDSIRASQALQQKHEEIESQ---HSEWFAVYVELNQQIAALLNAGDEEDLV 350
L A GD++ A Q L +KHE E+ H + Q + N +E
Sbjct: 1892 --LVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISS 1949
Query: 351 ELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADG 410
++K L ++SD+ + A+Q + + + A L+F+ A + + L D D
Sbjct: 1950 KMKGLNGKVSDL-EKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDL 2008
Query: 411 ASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQ---ASWAYGKDVTIENKENVDH 467
+S+Q L K ++ D GLQ +++G + + +Q A K + + +
Sbjct: 2009 SSVQTLL----TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKR 2064
Query: 468 IQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRL 527
++ + RK++ + R ++ LF A A E + L +R
Sbjct: 2065 WSQLLANSAARKKKLLEAQSHFR----KVEDLFLTFAKKASAFNSWFENAEEDLTDPVRC 2120
Query: 528 GDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVW 587
+ +E K L E H F S QL + + ++ + T+ L W
Sbjct: 2121 -NSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETW 2179
Query: 588 KQFTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAIN 626
+ +ER L+ +K+ Q+ + A +
Sbjct: 2180 RNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFH 2218
Score = 40.0 bits (92), Expect = 0.007
Identities = 74/369 (20%), Positives = 146/369 (39%), Gaps = 37/369 (10%)
Query: 243 AQPQVMKLLDSLREQYTRYQEVCRQRS-KRTQLEEIQQKVMQ---VVNWLEGPGSEQLRA 298
A + L L Q+ E R++ K Q +++ Q + + V++W+ E +
Sbjct: 116 ASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWIND--KEAIVT 173
Query: 299 QWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALL-NAGDEEDLVELKSLQQ 357
+G + + LQ+K EE ++ + E+NQ A L+ EE+L++ K Q
Sbjct: 174 SEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTK--QD 231
Query: 358 QLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLL---GMLCVDVAPADGASIQ 414
+++ R RQ L A E +D+ + + + ++ D D AS+Q
Sbjct: 232 EVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQ 291
Query: 415 QTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMED 474
L+ K + ++ L L +K + L A + + + IQ E+
Sbjct: 292 ALLR----KHEGLERDLAALEDKVKALC---------AEADRLQQSHPLSATQIQVKREE 338
Query: 475 MQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQET 534
+ ++ + R ++ +L + D W++E + AL+ L D
Sbjct: 339 LITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTE-MKALINAD-ELASDVAGA 396
Query: 535 KVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIAS 594
+ LL++H++ + D ++ Q+L + D V ++ T+ S
Sbjct: 397 EALLDRHQEH----KGEIDAHEDSFKSADESGQALLAAGHYASD------EVREKLTVLS 446
Query: 595 EERVHRLEM 603
EER LE+
Sbjct: 447 EERAALLEL 455
Score = 37.4 bits (85), Expect = 0.047
Identities = 57/276 (20%), Positives = 107/276 (38%), Gaps = 28/276 (10%)
Query: 339 ALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLL 398
+LL G++ + KS ++ + +R+A++L+ N +AAL V DL Q
Sbjct: 1075 SLLELGEKRKGMLEKSCKKFM---LFREANELQQWINEKEAALTSEEVGADLEQ------ 1125
Query: 399 GMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYG---K 455
V+V Q+ LK E +LK ++ + L +G + + Q YG +
Sbjct: 1126 ----VEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPR 1181
Query: 456 DVTIENKENVDHIQGVM----------EDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEED 505
D T + +M +++ R + + + + R + ++ + D
Sbjct: 1182 DETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRD 1241
Query: 506 AAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVL 565
A + EW+ E AL + G D + L KH F + D L + L
Sbjct: 1242 ADETKEWIEEKNQALNTDN--YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERL 1299
Query: 566 CQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRL 601
QS ++ + LN+ W +++R +L
Sbjct: 1300 IQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKL 1335
Score = 37.0 bits (84), Expect = 0.062
Identities = 48/228 (21%), Positives = 94/228 (41%), Gaps = 15/228 (6%)
Query: 463 ENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLK 522
E + IQ + + R R +++ +RR K+ + + DA + +W+ E L
Sbjct: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASD 69
Query: 523 THIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPR 582
+ + D + L+KH+ F Q+ +L + ++ S + L
Sbjct: 70 ENYK---DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLME 126
Query: 583 LNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAVGKSLL 642
L+R W+ E+ +L A + L++C + + IND+E E +G+ L
Sbjct: 127 LHRQWELLLEKMREKGIKLLQA----QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLE 182
Query: 643 DRLTVPVVYPDGTEQYFGSPSDMASTAENIRDRMKLVNLKRQQLRHPE 690
V V+ +++ +DMA+ E + + + K Q +HPE
Sbjct: 183 H---VEVL----QKKFEEFQTDMAAHEERVNE-VNQFAAKLIQEQHPE 222
Score = 32.7 bits (73), Expect = 1.2
Identities = 52/222 (23%), Positives = 89/222 (40%), Gaps = 36/222 (16%)
Query: 243 AQPQVMKLLDSLREQYTRYQEVCRQRSKRTQ----LEEIQQKVMQVVNWLEGPGSEQLRA 298
A +V + L L E+ E+ R ++ + L+ + QV NW+ E
Sbjct: 434 ASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK--QEAFLL 491
Query: 299 QWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQ 358
+GDS+ + +AL +KHE+ E S ++I AL DE +++
Sbjct: 492 NEDLGDSLDSVEALLKKHEDFEKSLS-------AQEEKITAL----DEFATKLIQNNHYA 540
Query: 359 LSDVCYRQASQLEFRQNLLQAAL--------EFHGVAQDLSQQLDGLLGML------CVD 404
+ DV R+ + L R L + A+ FH Q + D L + D
Sbjct: 541 MEDVATRRDALLSRRNALHERAMRRRAQLADSFH--LQQFFRDSDELKSWVNEKMKTATD 598
Query: 405 VAPADGASIQ---QTLKLLEEKLKSVDVGLQGLREKGQGLLD 443
A D +++Q Q + E +L + + L + GQ L+D
Sbjct: 599 EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLID 640
>gi|148529025 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4B [Homo sapiens]
Length = 1271
Score = 53.1 bits (126), Expect = 8e-07
Identities = 42/165 (25%), Positives = 74/165 (44%), Gaps = 16/165 (9%)
Query: 9 ILKKKLAFLSGGKDRRSGLILTIPL-----CLEQTNMDELSVTLDYLLSIPSEKCKARGF 63
+L+ + L G +DR ++ + E ++ EL+ L Y SIP ++ + G
Sbjct: 197 LLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGL 256
Query: 64 TVIVDGRKSQWN--VVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLG 121
V+VD R+S V + + + N P S++ +V + F +KD +
Sbjct: 257 VVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKES---------AFRPDKDAII 307
Query: 122 FEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKF 166
++ S + ++++ CQLT D GS Y H DW+ R E F
Sbjct: 308 QCEVVSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHF 352
>gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5
[Homo sapiens]
Length = 678
Score = 53.1 bits (126), Expect = 8e-07
Identities = 70/303 (23%), Positives = 125/303 (41%), Gaps = 20/303 (6%)
Query: 303 GDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDV 362
G + + +K + +ESQ EW+ EL Q AAL ++LV + Q + +
Sbjct: 115 GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGER--QNAVGER 172
Query: 363 CYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEE 422
R L+ R+ LL A+ E H VA DL +L + L + + G +Q + +++
Sbjct: 173 LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKK 232
Query: 423 KLKSVDVGLQGLREKGQG---LLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRK 479
QGLR + Q L+++ +A G ++ + E + ++ +E +Q
Sbjct: 233 N--------QGLRREIQAHGPRLEEVLERA----GALASLRSPE-AEAVRRGLEQLQSAW 279
Query: 480 QRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLE 539
+ + R+ + Q+ + D A+ WL E LL G D Q T LL+
Sbjct: 280 AGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE--QELLMMSEDKGKDEQSTLQLLK 337
Query: 540 KHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVH 599
KH + ++ + QL + L + S +++R++ EER
Sbjct: 338 KHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRV 397
Query: 600 RLE 602
LE
Sbjct: 398 ALE 400
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
sapiens]
Length = 2564
Score = 53.1 bits (126), Expect = 8e-07
Identities = 70/303 (23%), Positives = 125/303 (41%), Gaps = 20/303 (6%)
Query: 303 GDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDV 362
G + + +K + +ESQ EW+ EL Q AAL ++LV + Q + +
Sbjct: 1439 GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGER--QNAVGER 1496
Query: 363 CYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEE 422
R L+ R+ LL A+ E H VA DL +L + L + + G +Q + +++
Sbjct: 1497 LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKK 1556
Query: 423 KLKSVDVGLQGLREKGQG---LLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRK 479
QGLR + Q L+++ +A G ++ + E + ++ +E +Q
Sbjct: 1557 N--------QGLRREIQAHGPRLEEVLERA----GALASLRSPE-AEAVRRGLEQLQSAW 1603
Query: 480 QRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLE 539
+ + R+ + Q+ + D A+ WL E LL G D Q T LL+
Sbjct: 1604 AGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE--QELLMMSEDKGKDEQSTLQLLK 1661
Query: 540 KHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVH 599
KH + ++ + QL + L + S +++R++ EER
Sbjct: 1662 KHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRV 1721
Query: 600 RLE 602
LE
Sbjct: 1722 ALE 1724
Score = 45.4 bits (106), Expect = 2e-04
Identities = 38/185 (20%), Positives = 79/185 (42%), Gaps = 15/185 (8%)
Query: 380 ALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQ 439
AL FH +DL +DG+ + P D +S++ + QGL+ + +
Sbjct: 1944 ALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYH-----------QGLKTELE 1992
Query: 440 GLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQL 499
+ +++ G+ + + D IQ ++ + RK+ + D + QM+++
Sbjct: 1993 ARVPELTTCQE--LGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEV 2050
Query: 500 FKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLL 559
+ ++A A WL+ + LL++ LG E + L+ +H F A + + L
Sbjct: 2051 HQFAQEAVVADAWLT-AQEPLLQSR-ELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLR 2108
Query: 560 QATVV 564
+ T +
Sbjct: 2109 RLTTI 2113
>gi|153791325 MCF.2 cell line derived transforming sequence isoform
b [Homo sapiens]
Length = 925
Score = 50.1 bits (118), Expect = 7e-06
Identities = 30/92 (32%), Positives = 45/92 (48%), Gaps = 6/92 (6%)
Query: 89 PAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFE---VILVSANKLTRYIEPCQLTEDF 145
P + LV V++P F + T FW ++ + V+L S + L YI+ QLT +
Sbjct: 21 PGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPEL 80
Query: 146 GGSLTYDHMDWLNKRLVFEKF---TKESTSLL 174
GG+L Y H +W+ R E F KE +L
Sbjct: 81 GGTLQYCHSEWIIFRNAIENFALTVKEMAQML 112
Score = 34.7 bits (78), Expect = 0.31
Identities = 83/381 (21%), Positives = 158/381 (41%), Gaps = 49/381 (12%)
Query: 333 LNQQIAALLNAGDEEDLVELKSLQQQLSDVC-YRQASQLEFRQNLLQAALEFHGVAQDLS 391
L + L + D ++ K L +L Y + + FR + AL ++++
Sbjct: 54 LKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFAL----TVKEMA 109
Query: 392 QQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQIS-NQAS 450
Q L L P D SI++ L + E+ + + + ++G+ LL +
Sbjct: 110 QMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTE 169
Query: 451 WAYGKDVTIENKENVDH--IQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQ 508
A + + + D I ++ + + + + +LKM Q +QL+K E+D Q
Sbjct: 170 GAVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQ 229
Query: 509 AVEWLSELLDALLKTHIRLGDDAQ------ETKVLLEKHRKFVDVAQSTYDYGRQLL--- 559
V + LL+ + G AQ + + L E ++ + AQ +G +L
Sbjct: 230 LVTEVEFLLNQQAELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANH 289
Query: 560 -QATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQ-- 616
A ++CQ RC + L L+ + + +E + R++++ F K+LQ
Sbjct: 290 HYALDLICQ--RC------NELRYLSDI-----LVNEIKAKRIQLSRTF--KMHKLLQQA 334
Query: 617 -DCPEEPEAI--NDE-EQFDEIEAVGKSLLD-----RLTVPVV-YPDGTEQYFGSPSDMA 666
C +E E + N E ++F E K+L D + +P + Y T QY D+
Sbjct: 335 RQCCDEGECLLANQEIDKFQSKEDAQKALQDIENFLEMALPFINYEPETLQY---EFDVI 391
Query: 667 STAENIRDRMKLVNLKRQQLR 687
+ E ++ +MK + LK + +R
Sbjct: 392 LSPE-LKVQMKTIQLKLENIR 411
>gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
Length = 1519
Score = 48.9 bits (115), Expect = 2e-05
Identities = 95/436 (21%), Positives = 174/436 (39%), Gaps = 46/436 (10%)
Query: 17 LSGGKDRRSGLILTI-PLCLEQT---NMDELSVTLDYLLSIPSEKCKARGFTVIVDGRKS 72
L+GG D+ +LTI P C + + D L+ TL YL S+ + G +V++D R++
Sbjct: 538 LTGGVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQA 597
Query: 73 QW---NVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSA 129
++ + + + P V + ++ D+ T C ++ G EV+ S
Sbjct: 598 PPLPPALIPALSQLQDSGDPPLVQRLLILIHDDL----PTELCGFQ-----GAEVL--SE 646
Query: 130 NKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALINNGSDKGNQ 189
N L R +P +L + GG W+ + + +L + + +
Sbjct: 647 NDLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAE 706
Query: 190 QEKERSVDL-NFLPSV--DPE-TVLQT-GHELLSELQQRRFNGSDGGVSWSPMDDELLAQ 244
E+E +V + L V DP T LQ G +L L+ + +G
Sbjct: 707 PEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRSTPSSKLEGQ-----------GP 755
Query: 245 PQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGD 304
+ + +D Q R + Q+ ++ Q +++ QV+ WL GPG EQL + GD
Sbjct: 756 ATLYQEVDEAIHQLVRLSNLHVQQQEQRQC---LRRLQQVLQWLSGPGEEQLASFAMPGD 812
Query: 305 SIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCY 364
++ A Q + + ++ E A + + +A NA ++ L + +Q+ +
Sbjct: 813 TLSALQETELRFRAFSAEVQERLA---QAREALALEENATSQKVLDIFEQRLEQVESGLH 869
Query: 365 RQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKL 424
R F Q + E + +L L + AP A Q ++ L
Sbjct: 870 RALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRAL---- 925
Query: 425 KSVDVGL-QGLREKGQ 439
++D+G LRE G+
Sbjct: 926 -ALDLGSPAALREWGR 940
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 47.8 bits (112), Expect = 4e-05
Identities = 107/568 (18%), Positives = 225/568 (39%), Gaps = 73/568 (12%)
Query: 159 KRLVFEKFTKEST--SLLDELALINNGSDKGNQ--QEKERSVDLNFLPSVDPETVLQTGH 214
++L ++ KES+ LL + + + S K Q + K R + P D Q
Sbjct: 2638 EQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQ 2697
Query: 215 ELLSEL--QQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSK-- 270
EL E+ QQ + + V+ L Q + +LR+ +T Q+ ++R K
Sbjct: 2698 ELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA 2757
Query: 271 ---RTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWF 327
+ QL+E ++ V WL+ + ++ +++ L+++ E ++S +W
Sbjct: 2758 SSCQEQLDEFRKLVRTFQKWLK-----ETEGSIPPTETSMSAKELEKQIEHLKSLLDDWA 2812
Query: 328 A---VYVELNQQIAALLN------AGDEEDLVE--LKSLQQQLSDVC-YRQASQL-EFRQ 374
+ + E+N + +L N A D + L S+ + V Y L E +
Sbjct: 2813 SKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQC 2872
Query: 375 NLLQAALEFH---GVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDV-- 429
++ L++ GV + + L +L + + + S+ Q L+ EE LKS+D
Sbjct: 2873 DMSDVNLKYEKLGGVLHERQESLQAILNRM--EEVHKEANSVLQWLESKEEVLKSMDAMS 2930
Query: 430 ------GLQGLREKGQGLLDQISNQASWAY-------GKDVTIENKENVDHIQGVMEDMQ 476
++ E + L ++ + G VT N + ++ + + E++
Sbjct: 2931 SPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELN 2990
Query: 477 LRKQRCEDMVDVRRLKMLQMVQLFKCEEDA-AQAVEWLSE------LLDALLKTHIRLGD 529
R +R ++ R+ ++ + C + A +Q WL E +L L L
Sbjct: 2991 SRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNA 3050
Query: 530 DAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQ 589
Q+ + +L++ + + ++ + Q + + ++ L +N+ W +
Sbjct: 3051 QKQQVQFMLKEF----EARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVE 3106
Query: 590 FTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAVGKSLLDRLTVPV 649
T R +++ AI + +++LQD E ++ AVG+ L + +
Sbjct: 3107 LTDKLNSRSSQIDQAIVKSTQYQELLQDLSE------------KVRAVGQRLSVQSAIS- 3153
Query: 650 VYPDGTEQYFGSPSDMASTAENIRDRMK 677
P+ +Q S++ S E + +K
Sbjct: 3154 TQPEAVKQQLEETSEIRSDLEQLDHEVK 3181
Score = 45.8 bits (107), Expect = 1e-04
Identities = 98/456 (21%), Positives = 172/456 (37%), Gaps = 64/456 (14%)
Query: 207 ETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMK-LLDSLREQYTRYQEVC 265
ETV + G+ELL S G S + L A Q + +L E+ + Q
Sbjct: 4825 ETVNKAGNELLE---------SSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTL 4875
Query: 266 RQ-RSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHS 324
+Q + +++E+ ++ ++ QL A G ++ H E+ SQ
Sbjct: 4876 QQAQGFHSEIEDFLLELTRM--------ESQLSASKPTGGLPETAREQLDTHMELYSQLK 4927
Query: 325 EWFAVYVELNQQIAALLNAGD--------EEDLVELKSLQQQLSDVCYRQASQLEFRQNL 376
Y +L + +L + D E+ + L+ +S + S+LE NL
Sbjct: 4928 AKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNL 4987
Query: 377 LQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEK---LKSVDVGLQG 433
A EF Q+ L L +++A + L +EE V+
Sbjct: 4988 ---ATEFQNSLQEFINWLT--LAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 5042
Query: 434 LREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKM 493
+ E LDQ NQ + K + K + +Q E + R +D R +
Sbjct: 5043 IIE-----LDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA 5097
Query: 494 LQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVA---QS 550
Q + +K + ++WL + ++ L + + + +D + K+ L KH++F Q
Sbjct: 5098 KQFHEAWK------KLIDWLEDA-ESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQP 5150
Query: 551 TYDY----GRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAIA 606
YD GR L + T+ L S+ + L + W S ER H+LE A+
Sbjct: 5151 VYDTTIRTGRALKEKTL-----LPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 5205
Query: 607 FHSNAEKILQDCPE-----EPEAINDEEQFDEIEAV 637
F LQ + EP+ D+ +++ V
Sbjct: 5206 FSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLV 5241
Score = 37.0 bits (84), Expect = 0.062
Identities = 90/455 (19%), Positives = 180/455 (39%), Gaps = 75/455 (16%)
Query: 192 KERSVDLNFL-PSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDEL--------- 241
K +V+L L PS E + + G EL+ Q G+D ++ + D+L
Sbjct: 4479 KSATVELEKLQPSF--EALKRRGEELIGRSQ-----GADKDLAAKEIQDKLDQMVFFWED 4531
Query: 242 ---LAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRA 298
A+ + +K LD L + ++ + T +++ Q +V+ LE PG +
Sbjct: 4532 IKARAEEREIKFLDVLELAEKFWYDMA---ALLTTIKDTQD----IVHDLESPGIDPSI- 4583
Query: 299 QWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQ 358
I + A++ ++ EE + H E + + I A E + +
Sbjct: 4584 ---IKQQVEAAETIK---EETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA 4637
Query: 359 LSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLK 418
++ +LE ++ +QAA+++ Q + LD + LC P G +
Sbjct: 4638 WENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC--TMPPVGTDLNTVKD 4695
Query: 419 LLEE------KLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHI-QGV 471
L E ++ + ++ L +G+ +L + +++ +D+ E + H+ + +
Sbjct: 4696 QLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETD----RDIIREPLTELKHLWENL 4751
Query: 472 MEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDA 531
E + R+ + E ++ L + + + + WL+ + LL + D
Sbjct: 4752 GEKIAHRQHKLEG----------ALLALGQFQHALEELMSWLTH-TEELLDAQRPISGDP 4800
Query: 532 QETKVLLEKH---RKFVDVAQSTYD----YGRQLLQATVVLCQSLRCTSRSSGDTLPRLN 584
+ +V L KH + V Q+T + G +LL++ S + S L +N
Sbjct: 4801 KVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLES------SAGDDASSLRSRLEAMN 4854
Query: 585 RVWKQFTIASEERVHR----LEMAIAFHSNAEKIL 615
+ W+ +EER + L+ A FHS E L
Sbjct: 4855 QCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFL 4889
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 47.8 bits (112), Expect = 4e-05
Identities = 107/568 (18%), Positives = 225/568 (39%), Gaps = 73/568 (12%)
Query: 159 KRLVFEKFTKEST--SLLDELALINNGSDKGNQ--QEKERSVDLNFLPSVDPETVLQTGH 214
++L ++ KES+ LL + + + S K Q + K R + P D Q
Sbjct: 2136 EQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQ 2195
Query: 215 ELLSEL--QQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSK-- 270
EL E+ QQ + + V+ L Q + +LR+ +T Q+ ++R K
Sbjct: 2196 ELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA 2255
Query: 271 ---RTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWF 327
+ QL+E ++ V WL+ + ++ +++ L+++ E ++S +W
Sbjct: 2256 SSCQEQLDEFRKLVRTFQKWLK-----ETEGSIPPTETSMSAKELEKQIEHLKSLLDDWA 2310
Query: 328 A---VYVELNQQIAALLN------AGDEEDLVE--LKSLQQQLSDVC-YRQASQL-EFRQ 374
+ + E+N + +L N A D + L S+ + V Y L E +
Sbjct: 2311 SKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQC 2370
Query: 375 NLLQAALEFH---GVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDV-- 429
++ L++ GV + + L +L + + + S+ Q L+ EE LKS+D
Sbjct: 2371 DMSDVNLKYEKLGGVLHERQESLQAILNRM--EEVHKEANSVLQWLESKEEVLKSMDAMS 2428
Query: 430 ------GLQGLREKGQGLLDQISNQASWAY-------GKDVTIENKENVDHIQGVMEDMQ 476
++ E + L ++ + G VT N + ++ + + E++
Sbjct: 2429 SPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELN 2488
Query: 477 LRKQRCEDMVDVRRLKMLQMVQLFKCEEDA-AQAVEWLSE------LLDALLKTHIRLGD 529
R +R ++ R+ ++ + C + A +Q WL E +L L L
Sbjct: 2489 SRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNA 2548
Query: 530 DAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQ 589
Q+ + +L++ + + ++ + Q + + ++ L +N+ W +
Sbjct: 2549 QKQQVQFMLKEF----EARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVE 2604
Query: 590 FTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAVGKSLLDRLTVPV 649
T R +++ AI + +++LQD E ++ AVG+ L + +
Sbjct: 2605 LTDKLNSRSSQIDQAIVKSTQYQELLQDLSE------------KVRAVGQRLSVQSAIS- 2651
Query: 650 VYPDGTEQYFGSPSDMASTAENIRDRMK 677
P+ +Q S++ S E + +K
Sbjct: 2652 TQPEAVKQQLEETSEIRSDLEQLDHEVK 2679
Score = 45.8 bits (107), Expect = 1e-04
Identities = 98/456 (21%), Positives = 172/456 (37%), Gaps = 64/456 (14%)
Query: 207 ETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMK-LLDSLREQYTRYQEVC 265
ETV + G+ELL S G S + L A Q + +L E+ + Q
Sbjct: 4323 ETVNKAGNELLE---------SSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTL 4373
Query: 266 RQ-RSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHS 324
+Q + +++E+ ++ ++ QL A G ++ H E+ SQ
Sbjct: 4374 QQAQGFHSEIEDFLLELTRM--------ESQLSASKPTGGLPETAREQLDTHMELYSQLK 4425
Query: 325 EWFAVYVELNQQIAALLNAGD--------EEDLVELKSLQQQLSDVCYRQASQLEFRQNL 376
Y +L + +L + D E+ + L+ +S + S+LE NL
Sbjct: 4426 AKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNL 4485
Query: 377 LQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEK---LKSVDVGLQG 433
A EF Q+ L L +++A + L +EE V+
Sbjct: 4486 ---ATEFQNSLQEFINWLT--LAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 4540
Query: 434 LREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKM 493
+ E LDQ NQ + K + K + +Q E + R +D R +
Sbjct: 4541 IIE-----LDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA 4595
Query: 494 LQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVA---QS 550
Q + +K + ++WL + ++ L + + + +D + K+ L KH++F Q
Sbjct: 4596 KQFHEAWK------KLIDWLEDA-ESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQP 4648
Query: 551 TYDY----GRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAIA 606
YD GR L + T+ L S+ + L + W S ER H+LE A+
Sbjct: 4649 VYDTTIRTGRALKEKTL-----LPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 4703
Query: 607 FHSNAEKILQDCPE-----EPEAINDEEQFDEIEAV 637
F LQ + EP+ D+ +++ V
Sbjct: 4704 FSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLV 4739
Score = 37.0 bits (84), Expect = 0.062
Identities = 90/455 (19%), Positives = 180/455 (39%), Gaps = 75/455 (16%)
Query: 192 KERSVDLNFL-PSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDEL--------- 241
K +V+L L PS E + + G EL+ Q G+D ++ + D+L
Sbjct: 3977 KSATVELEKLQPSF--EALKRRGEELIGRSQ-----GADKDLAAKEIQDKLDQMVFFWED 4029
Query: 242 ---LAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRA 298
A+ + +K LD L + ++ + T +++ Q +V+ LE PG +
Sbjct: 4030 IKARAEEREIKFLDVLELAEKFWYDMA---ALLTTIKDTQD----IVHDLESPGIDPSI- 4081
Query: 299 QWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQ 358
I + A++ ++ EE + H E + + I A E + +
Sbjct: 4082 ---IKQQVEAAETIK---EETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA 4135
Query: 359 LSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLK 418
++ +LE ++ +QAA+++ Q + LD + LC P G +
Sbjct: 4136 WENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC--TMPPVGTDLNTVKD 4193
Query: 419 LLEE------KLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHI-QGV 471
L E ++ + ++ L +G+ +L + +++ +D+ E + H+ + +
Sbjct: 4194 QLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETD----RDIIREPLTELKHLWENL 4249
Query: 472 MEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDA 531
E + R+ + E ++ L + + + + WL+ + LL + D
Sbjct: 4250 GEKIAHRQHKLEG----------ALLALGQFQHALEELMSWLTH-TEELLDAQRPISGDP 4298
Query: 532 QETKVLLEKH---RKFVDVAQSTYD----YGRQLLQATVVLCQSLRCTSRSSGDTLPRLN 584
+ +V L KH + V Q+T + G +LL++ S + S L +N
Sbjct: 4299 KVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLES------SAGDDASSLRSRLEAMN 4352
Query: 585 RVWKQFTIASEERVHR----LEMAIAFHSNAEKIL 615
+ W+ +EER + L+ A FHS E L
Sbjct: 4353 QCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFL 4387
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 46.6 bits (109), Expect = 8e-05
Identities = 71/265 (26%), Positives = 119/265 (44%), Gaps = 24/265 (9%)
Query: 254 LREQYTRYQEVCRQ-RSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQAL 312
LR+ + +E+ R+ RT EEI + + L+G +E LR Q + S RA +
Sbjct: 1672 LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1731
Query: 313 QQKHEEIESQHSEW---FAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQ 369
QQ +E+ + + A +E +Q+ L EE+L E +S + L+D + Q
Sbjct: 1732 QQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ-LEEELEEEQSNSELLNDRYRKLLLQ 1790
Query: 370 LEFRQNLLQAALEFHGVA----QDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLK 425
+E L A F A Q L +Q+ L G L + A A A + T+ LE KL
Sbjct: 1791 VESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGA-RARHKMTIAALESKLA 1849
Query: 426 SVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDM 485
+ L+ +E + +L GK V K + + V E+ ++ Q D
Sbjct: 1850 QAEEQLE--QETRERILS----------GKLVRRAEKRLKEVVLQVEEERRVADQ-LRDQ 1896
Query: 486 VDVRRLKMLQMV-QLFKCEEDAAQA 509
++ L++ Q+ QL + EE+A++A
Sbjct: 1897 LEKGNLRVKQLKRQLEEAEEEASRA 1921
Score = 38.1 bits (87), Expect = 0.028
Identities = 73/341 (21%), Positives = 138/341 (40%), Gaps = 54/341 (15%)
Query: 307 RASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQ 366
R + LQ + +E++ EL QQ A ++ EL+ QL + R
Sbjct: 874 RQDEVLQARAQELQKVQ--------ELQQQSA--------REVGELQGRVAQLEEERARL 917
Query: 367 ASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGAS--IQQTLKLLEEKL 424
A QL L A E G Q+L+ ++ L V + S +Q K L++ +
Sbjct: 918 AEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHI 977
Query: 425 KSVDVGLQ---GLREKGQGLLDQISNQASWA-YGKDVTIENKEN--VDHIQGVMEDM--Q 476
+ ++ L+ G R+K Q L++++ +A + +D+ + +N + + ++ED +
Sbjct: 978 QELEAHLEAEEGARQKLQ--LEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAE 1035
Query: 477 LRKQRCEDMVDVRRLKMLQ---------MVQLFKCEEDAAQAVEWLSELLDALLKTHIRL 527
Q E+ V+ L L+ M + EE Q +E L LD
Sbjct: 1036 FSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLD--------- 1086
Query: 528 GDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVW 587
G+ ++ + ++E+ ++ ++ GR+ + L ++ G +L +
Sbjct: 1087 GESSELQEQMVEQQQRAEELRAQL---GRKEEELQAALARA-----EDEGGARAQLLKSL 1138
Query: 588 KQFTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDE 628
++ A E LE + AEK +D EE EA+ E
Sbjct: 1139 REAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGE 1179
Score = 35.4 bits (80), Expect = 0.18
Identities = 67/294 (22%), Positives = 123/294 (41%), Gaps = 35/294 (11%)
Query: 257 QYTRYQEVCRQRSKRTQ-LEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQK 315
Q TR EV + R++ Q ++E+QQ+ + V L+G ++ + + + +RA L +
Sbjct: 871 QVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE 930
Query: 316 HEE----IESQHSEWFAVYVELNQQIAALLNAGDEEDL-----VELKSLQQQLSDVCYRQ 366
EE + ++ E V EL ++ G+EE+ E K LQQ + ++
Sbjct: 931 AEETRGRLAARKQELELVVSELEARV------GEEEECSRQMQTEKKRLQQHIQELEAHL 984
Query: 367 ASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKS 426
++ RQ L + + + L +L D + + + KLLE++L
Sbjct: 985 EAEEGARQKLQLEKVTTEAKMKKFEEDL-----LLLED----QNSKLSKERKLLEDRLAE 1035
Query: 427 VDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKEN-VDHIQGVMEDMQLRKQRCEDM 485
EK + L N+ Y + TI + E+ + + ++++ K+R +
Sbjct: 1036 FSSQAAEEEEKVKSL-----NKLRLKY--EATIADMEDRLRKEEKGRQELEKLKRRLDGE 1088
Query: 486 VDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLE 539
+ +M++ Q + EE AQ EL AL + G AQ K L E
Sbjct: 1089 SSELQEQMVEQQQ--RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLRE 1140
Score = 30.4 bits (67), Expect = 5.8
Identities = 56/256 (21%), Positives = 107/256 (41%), Gaps = 40/256 (15%)
Query: 252 DSLREQYTRYQEVCR-QRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQ 310
D LR++ QE+ + +R + E+Q+++++ + +E+LRAQ G R +
Sbjct: 1066 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVE-----QQQRAEELRAQLG-----RKEE 1115
Query: 311 ALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGD--EEDLVELKSLQQQLSDVCYRQAS 368
LQ E + + L + AAL A + E + V ++Q D+
Sbjct: 1116 ELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDL----GE 1171
Query: 369 QLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVD 428
+LE + L+ L+ Q+L + + + + K LEE+ + +
Sbjct: 1172 ELEALRGELEDTLDSTNAQQELRSKRE---------------QEVTELKKTLEEETRIHE 1216
Query: 429 VGLQGLREKGQGLLDQISNQASWA-YGK----DVTIENKENVDHIQGVMEDMQLRKQRCE 483
+Q LR++ L +++ Q A GK + + V ++ + +Q +Q E
Sbjct: 1217 AAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGE 1276
Query: 484 DMVDVRRLKM-LQMVQ 498
RRL++ LQ VQ
Sbjct: 1277 QR--RRRLELQLQEVQ 1290
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 46.6 bits (109), Expect = 8e-05
Identities = 71/265 (26%), Positives = 119/265 (44%), Gaps = 24/265 (9%)
Query: 254 LREQYTRYQEVCRQ-RSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQAL 312
LR+ + +E+ R+ RT EEI + + L+G +E LR Q + S RA +
Sbjct: 1664 LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1723
Query: 313 QQKHEEIESQHSEW---FAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQ 369
QQ +E+ + + A +E +Q+ L EE+L E +S + L+D + Q
Sbjct: 1724 QQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ-LEEELEEEQSNSELLNDRYRKLLLQ 1782
Query: 370 LEFRQNLLQAALEFHGVA----QDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLK 425
+E L A F A Q L +Q+ L G L + A A A + T+ LE KL
Sbjct: 1783 VESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGA-RARHKMTIAALESKLA 1841
Query: 426 SVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDM 485
+ L+ +E + +L GK V K + + V E+ ++ Q D
Sbjct: 1842 QAEEQLE--QETRERILS----------GKLVRRAEKRLKEVVLQVEEERRVADQ-LRDQ 1888
Query: 486 VDVRRLKMLQMV-QLFKCEEDAAQA 509
++ L++ Q+ QL + EE+A++A
Sbjct: 1889 LEKGNLRVKQLKRQLEEAEEEASRA 1913
Score = 38.1 bits (87), Expect = 0.028
Identities = 73/341 (21%), Positives = 138/341 (40%), Gaps = 54/341 (15%)
Query: 307 RASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQ 366
R + LQ + +E++ EL QQ A ++ EL+ QL + R
Sbjct: 866 RQDEVLQARAQELQKVQ--------ELQQQSA--------REVGELQGRVAQLEEERARL 909
Query: 367 ASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGAS--IQQTLKLLEEKL 424
A QL L A E G Q+L+ ++ L V + S +Q K L++ +
Sbjct: 910 AEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHI 969
Query: 425 KSVDVGLQ---GLREKGQGLLDQISNQASWA-YGKDVTIENKEN--VDHIQGVMEDM--Q 476
+ ++ L+ G R+K Q L++++ +A + +D+ + +N + + ++ED +
Sbjct: 970 QELEAHLEAEEGARQKLQ--LEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAE 1027
Query: 477 LRKQRCEDMVDVRRLKMLQ---------MVQLFKCEEDAAQAVEWLSELLDALLKTHIRL 527
Q E+ V+ L L+ M + EE Q +E L LD
Sbjct: 1028 FSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLD--------- 1078
Query: 528 GDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVW 587
G+ ++ + ++E+ ++ ++ GR+ + L ++ G +L +
Sbjct: 1079 GESSELQEQMVEQQQRAEELRAQL---GRKEEELQAALARA-----EDEGGARAQLLKSL 1130
Query: 588 KQFTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDE 628
++ A E LE + AEK +D EE EA+ E
Sbjct: 1131 REAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGE 1171
Score = 35.4 bits (80), Expect = 0.18
Identities = 67/294 (22%), Positives = 123/294 (41%), Gaps = 35/294 (11%)
Query: 257 QYTRYQEVCRQRSKRTQ-LEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQK 315
Q TR EV + R++ Q ++E+QQ+ + V L+G ++ + + + +RA L +
Sbjct: 863 QVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE 922
Query: 316 HEE----IESQHSEWFAVYVELNQQIAALLNAGDEEDL-----VELKSLQQQLSDVCYRQ 366
EE + ++ E V EL ++ G+EE+ E K LQQ + ++
Sbjct: 923 AEETRGRLAARKQELELVVSELEARV------GEEEECSRQMQTEKKRLQQHIQELEAHL 976
Query: 367 ASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKS 426
++ RQ L + + + L +L D + + + KLLE++L
Sbjct: 977 EAEEGARQKLQLEKVTTEAKMKKFEEDL-----LLLED----QNSKLSKERKLLEDRLAE 1027
Query: 427 VDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKEN-VDHIQGVMEDMQLRKQRCEDM 485
EK + L N+ Y + TI + E+ + + ++++ K+R +
Sbjct: 1028 FSSQAAEEEEKVKSL-----NKLRLKY--EATIADMEDRLRKEEKGRQELEKLKRRLDGE 1080
Query: 486 VDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLE 539
+ +M++ Q + EE AQ EL AL + G AQ K L E
Sbjct: 1081 SSELQEQMVEQQQ--RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLRE 1132
Score = 30.4 bits (67), Expect = 5.8
Identities = 56/256 (21%), Positives = 107/256 (41%), Gaps = 40/256 (15%)
Query: 252 DSLREQYTRYQEVCR-QRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQ 310
D LR++ QE+ + +R + E+Q+++++ + +E+LRAQ G R +
Sbjct: 1058 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVE-----QQQRAEELRAQLG-----RKEE 1107
Query: 311 ALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGD--EEDLVELKSLQQQLSDVCYRQAS 368
LQ E + + L + AAL A + E + V ++Q D+
Sbjct: 1108 ELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDL----GE 1163
Query: 369 QLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVD 428
+LE + L+ L+ Q+L + + + + K LEE+ + +
Sbjct: 1164 ELEALRGELEDTLDSTNAQQELRSKRE---------------QEVTELKKTLEEETRIHE 1208
Query: 429 VGLQGLREKGQGLLDQISNQASWA-YGK----DVTIENKENVDHIQGVMEDMQLRKQRCE 483
+Q LR++ L +++ Q A GK + + V ++ + +Q +Q E
Sbjct: 1209 AAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGE 1268
Query: 484 DMVDVRRLKM-LQMVQ 498
RRL++ LQ VQ
Sbjct: 1269 QR--RRRLELQLQEVQ 1282
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 46.6 bits (109), Expect = 8e-05
Identities = 71/265 (26%), Positives = 119/265 (44%), Gaps = 24/265 (9%)
Query: 254 LREQYTRYQEVCRQ-RSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQAL 312
LR+ + +E+ R+ RT EEI + + L+G +E LR Q + S RA +
Sbjct: 1705 LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1764
Query: 313 QQKHEEIESQHSEW---FAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQ 369
QQ +E+ + + A +E +Q+ L EE+L E +S + L+D + Q
Sbjct: 1765 QQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ-LEEELEEEQSNSELLNDRYRKLLLQ 1823
Query: 370 LEFRQNLLQAALEFHGVA----QDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLK 425
+E L A F A Q L +Q+ L G L + A A A + T+ LE KL
Sbjct: 1824 VESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGA-RARHKMTIAALESKLA 1882
Query: 426 SVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDM 485
+ L+ +E + +L GK V K + + V E+ ++ Q D
Sbjct: 1883 QAEEQLE--QETRERILS----------GKLVRRAEKRLKEVVLQVEEERRVADQ-LRDQ 1929
Query: 486 VDVRRLKMLQMV-QLFKCEEDAAQA 509
++ L++ Q+ QL + EE+A++A
Sbjct: 1930 LEKGNLRVKQLKRQLEEAEEEASRA 1954
Score = 38.1 bits (87), Expect = 0.028
Identities = 73/341 (21%), Positives = 138/341 (40%), Gaps = 54/341 (15%)
Query: 307 RASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQ 366
R + LQ + +E++ EL QQ A ++ EL+ QL + R
Sbjct: 907 RQDEVLQARAQELQKVQ--------ELQQQSA--------REVGELQGRVAQLEEERARL 950
Query: 367 ASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGAS--IQQTLKLLEEKL 424
A QL L A E G Q+L+ ++ L V + S +Q K L++ +
Sbjct: 951 AEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHI 1010
Query: 425 KSVDVGLQ---GLREKGQGLLDQISNQASWA-YGKDVTIENKEN--VDHIQGVMEDM--Q 476
+ ++ L+ G R+K Q L++++ +A + +D+ + +N + + ++ED +
Sbjct: 1011 QELEAHLEAEEGARQKLQ--LEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAE 1068
Query: 477 LRKQRCEDMVDVRRLKMLQ---------MVQLFKCEEDAAQAVEWLSELLDALLKTHIRL 527
Q E+ V+ L L+ M + EE Q +E L LD
Sbjct: 1069 FSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLD--------- 1119
Query: 528 GDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVW 587
G+ ++ + ++E+ ++ ++ GR+ + L ++ G +L +
Sbjct: 1120 GESSELQEQMVEQQQRAEELRAQL---GRKEEELQAALARA-----EDEGGARAQLLKSL 1171
Query: 588 KQFTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDE 628
++ A E LE + AEK +D EE EA+ E
Sbjct: 1172 REAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGE 1212
Score = 35.4 bits (80), Expect = 0.18
Identities = 67/294 (22%), Positives = 123/294 (41%), Gaps = 35/294 (11%)
Query: 257 QYTRYQEVCRQRSKRTQ-LEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQK 315
Q TR EV + R++ Q ++E+QQ+ + V L+G ++ + + + +RA L +
Sbjct: 904 QVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE 963
Query: 316 HEE----IESQHSEWFAVYVELNQQIAALLNAGDEEDL-----VELKSLQQQLSDVCYRQ 366
EE + ++ E V EL ++ G+EE+ E K LQQ + ++
Sbjct: 964 AEETRGRLAARKQELELVVSELEARV------GEEEECSRQMQTEKKRLQQHIQELEAHL 1017
Query: 367 ASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKS 426
++ RQ L + + + L +L D + + + KLLE++L
Sbjct: 1018 EAEEGARQKLQLEKVTTEAKMKKFEEDL-----LLLED----QNSKLSKERKLLEDRLAE 1068
Query: 427 VDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKEN-VDHIQGVMEDMQLRKQRCEDM 485
EK + L N+ Y + TI + E+ + + ++++ K+R +
Sbjct: 1069 FSSQAAEEEEKVKSL-----NKLRLKY--EATIADMEDRLRKEEKGRQELEKLKRRLDGE 1121
Query: 486 VDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLE 539
+ +M++ Q + EE AQ EL AL + G AQ K L E
Sbjct: 1122 SSELQEQMVEQQQ--RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLRE 1173
Score = 30.4 bits (67), Expect = 5.8
Identities = 56/256 (21%), Positives = 107/256 (41%), Gaps = 40/256 (15%)
Query: 252 DSLREQYTRYQEVCR-QRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQ 310
D LR++ QE+ + +R + E+Q+++++ + +E+LRAQ G R +
Sbjct: 1099 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVE-----QQQRAEELRAQLG-----RKEE 1148
Query: 311 ALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGD--EEDLVELKSLQQQLSDVCYRQAS 368
LQ E + + L + AAL A + E + V ++Q D+
Sbjct: 1149 ELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDL----GE 1204
Query: 369 QLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVD 428
+LE + L+ L+ Q+L + + + + K LEE+ + +
Sbjct: 1205 ELEALRGELEDTLDSTNAQQELRSKRE---------------QEVTELKKTLEEETRIHE 1249
Query: 429 VGLQGLREKGQGLLDQISNQASWA-YGK----DVTIENKENVDHIQGVMEDMQLRKQRCE 483
+Q LR++ L +++ Q A GK + + V ++ + +Q +Q E
Sbjct: 1250 AAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGE 1309
Query: 484 DMVDVRRLKM-LQMVQ 498
RRL++ LQ VQ
Sbjct: 1310 QR--RRRLELQLQEVQ 1323
>gi|81295809 pericentrin [Homo sapiens]
Length = 3336
Score = 44.7 bits (104), Expect = 3e-04
Identities = 105/516 (20%), Positives = 198/516 (38%), Gaps = 88/516 (17%)
Query: 180 INNGSDKGNQQEKE--RSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPM 237
+ + +G+QQE + R V+L + + + LSE Q++ + +
Sbjct: 2546 LTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKA----------NSV 2595
Query: 238 DDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLE----EIQQKVMQVVNWLEGPGS 293
L A+ V++ L S ++C R K QL E+QQ+V+Q+ + L +
Sbjct: 2596 QKLLAAEQTVVRDLKS---------DLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKEN 2646
Query: 294 EQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELK 353
E A + +ALQ + EE + +H ++ Q A L EE L+
Sbjct: 2647 ELKAALQELESEQGKGRALQSQLEEEQLRH-------LQRESQSAKAL----EELRASLE 2695
Query: 354 SLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASI 413
+ + Q S +C + + NL + H + L Q L L D+A ++
Sbjct: 2696 TQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTL 2755
Query: 414 QQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVME 473
+ + L E+L + + L ++ Q QA A + + E K V +Q ++E
Sbjct: 2756 ELSEALRHERLLT-----EQLSQRTQEACVHQDTQAHHALLQKLK-EEKSRVVDLQAMLE 2809
Query: 474 DMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQE 533
+Q + + ++ K CE A+ E+ L T L +E
Sbjct: 2810 KVQQQALHSQQQLEAEAQK--------HCE-----ALRREKEVSATLKSTVEALHTQKRE 2856
Query: 534 TKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDT--LPRLNRVWKQFT 591
+ LE+ R+ Q+ + L+ Q R +R S + P W+++
Sbjct: 2857 LRCSLEREREKPAWLQAELEQSHPRLKE-----QEGRKAARRSAEARQSPAAAEQWRKWQ 2911
Query: 592 IASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAVGKSLLDRLTVPVVY 651
+E++ LE+ ++ L + + + D E DE+
Sbjct: 2912 -RDKEKLRELEL------QRQRDLHKIKQLQQTVRDLESKDEV----------------- 2947
Query: 652 PDGTEQYFGSPSDMA-STAENIRDRMKLVNLKRQQL 686
G+ + GS A S A+++R++ + + RQ+L
Sbjct: 2948 -PGSRLHLGSARRAAGSDADHLREQQRELEAMRQRL 2982
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 43.9 bits (102), Expect = 5e-04
Identities = 102/508 (20%), Positives = 204/508 (40%), Gaps = 60/508 (11%)
Query: 201 LPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTR 260
L ++ P+++ E + LQQ+ + SW + + AQ + L+ L+ + +
Sbjct: 8 LNNMKPQSLQLVLEEQVLALQQQM--AENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQ 65
Query: 261 YQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIE 320
Y+ C++ KR LE + Q +E P ++L + + QQ+ E +
Sbjct: 66 YRSWCQELEKR--LEATGGPIPQRWENVEEPNLDELLVR---------LEEEQQRCESLA 114
Query: 321 SQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAA 380
+++ + L+ + A ++N ED+ +L + D R+ SQ + Q +
Sbjct: 115 EVNTQ-----LRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGY 169
Query: 381 LE-FHGVAQDLSQQL----DGLLGMLCV---DVAPADGASIQQTLKLLEEKLKSVDVGLQ 432
L+ HG L +++ L M D+ ++ + LL L+ + VG Q
Sbjct: 170 LKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLR-LTVGAQ 228
Query: 433 GLREKGQGLLD-QISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRL 491
G G +D + Q K +E + + + + Q ++ E V L
Sbjct: 229 SREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTEL 288
Query: 492 KMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGD-------DAQETKVLLEKHRKF 544
L + Q K ED + ++ L E ++ L H L + +AQE K+ L++ K
Sbjct: 289 SAL-LTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIK- 346
Query: 545 VDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMA 604
D+ Q + G + Q + ++L + ++ QF ++ L +
Sbjct: 347 -DITQVMVEEGDNIAQGS------------GHENSLELDSSIFSQFDYQDADKALTLVRS 393
Query: 605 IAFHSNAEKILQDCPEE----PEAIN-DEEQFDEIEAVGKSLLDRLTVPVVYPDGTEQYF 659
+ + + +QD ++ EA+N ++Q D+ E GK+L RL +
Sbjct: 394 VL--TRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQ---KLTGERDTLA 448
Query: 660 GSPSDMASTAENIRDRMKLVNLKRQQLR 687
G D+ +++ +L+ R++LR
Sbjct: 449 GQTVDLQGEVDSLSKERELLQKAREELR 476
>gi|7705415 hook homolog 1 [Homo sapiens]
Length = 728
Score = 42.7 bits (99), Expect = 0.001
Identities = 79/355 (22%), Positives = 149/355 (41%), Gaps = 49/355 (13%)
Query: 153 HMDWLNKRLV--------FEKFTKESTSLLDELALINNGSDKGNQQE------KERSVDL 198
H + L K+L+ +E+ +L DE+ ++ SDK N+ E +++ DL
Sbjct: 274 HCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDL 333
Query: 199 NFL---PSVDPETVLQTGHELLS-ELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSL 254
N L ET + H +S E + ++ N + + Q +KL
Sbjct: 334 NDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQ----VQDLHVKLSSES 389
Query: 255 REQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQ 314
+ T E+ R K L + ++++++ + L+ +E+LR D + + A
Sbjct: 390 KRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLK-ETNEELRCSQVQQDHLNQTDASAT 448
Query: 315 KHEE---IESQHSEWFAVYVELNQQ--IAALLNAGDEEDLVELKSLQQQLSDVCYRQASQ 369
K E E E+ V++ L + + L G E + +E LQ+QL +R+ ++
Sbjct: 449 KSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIE--ELQEQLEQK-HRKMNE 505
Query: 370 LEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGAS---IQQTLKLLEEKLKS 426
LE Q L + + ++L QQ++ L L + ++G S ++Q L+ EKL
Sbjct: 506 LETEQRLSKERI------RELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTE 559
Query: 427 VDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQR 481
V LQ +E + L I+ + ++ K+ EDM+ ++R
Sbjct: 560 VHEELQKKQELIEDLQPDINQNVQKINELEAALQKKD---------EDMKAMEER 605
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 42.4 bits (98), Expect = 0.001
Identities = 81/439 (18%), Positives = 167/439 (38%), Gaps = 53/439 (12%)
Query: 207 ETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDE-LLAQPQVMKLLDSLREQYTRYQEVC 265
E ++ + + ELQ + S G S +D + L Q + M+LL+ L E R +
Sbjct: 1413 ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNE---RKHNLL 1469
Query: 266 RQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQ--- 322
+ +++ +++ V + L G +++ Q L +K++ ++ +
Sbjct: 1470 ASKEIHQFNRDVEDEILWVGERMP------LATSTDHGHNLQTVQLLIKKNQTLQKEIQG 1523
Query: 323 HSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALE 382
H E +Q I + + ++++Q+L+D+ +E + + E
Sbjct: 1524 HQPRIDDIFERSQNIVT------DSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEE 1577
Query: 383 FHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLL 442
H Q D A A+ +Q L ++ E+ + + +K Q L
Sbjct: 1578 AHRAQQ------------YYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILE 1625
Query: 443 DQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCE-------DMVDVRRLKMLQ 495
+ + A + T H + E + +R+ + + D+ + RR K+ +
Sbjct: 1626 QAVEDYAETVHQLSKTSRALVADSHPES--ERISMRQSKVDKLYAGLKDLAEERRGKLDE 1683
Query: 496 MVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYG 555
+LF+ + +W++E + + +H LG D + +L E+ R+F A+ T + G
Sbjct: 1684 RHRLFQLNREVDDLEQWIAE-REVVAGSH-ELGQDYEHVTMLQERFREF---ARDTGNIG 1738
Query: 556 RQLLQATVVLCQSLRCTSRSSGDTLPR----LNRVWKQFTIASEERVHRLEMAIAFHSNA 611
++ + L L + S T+ LN W + R L + H
Sbjct: 1739 QERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELH--- 1795
Query: 612 EKILQDCPEEPEAINDEEQ 630
K D E I D+ +
Sbjct: 1796 -KFYHDAKEIFGRIQDKHK 1813
Score = 34.7 bits (78), Expect = 0.31
Identities = 68/361 (18%), Positives = 137/361 (37%), Gaps = 56/361 (15%)
Query: 235 SPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVN----WLEG 290
S + E P V L + E+Y E+ R R + Q K+ + W++
Sbjct: 795 SALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWID- 853
Query: 291 PGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLV 350
EQ I + + + +Q + E +E + + + +NQ L+++G +
Sbjct: 854 -EKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE-K 911
Query: 351 ELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGV--------------------AQDL 390
E+K+ Q +L+ + ++ +++ L +AL QDL
Sbjct: 912 EIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDL 971
Query: 391 SQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQAS 450
L G++ ++Q+ L +E L +++ L L+++ + L + +QA
Sbjct: 972 GNDLAGVM-------------ALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQ 1018
Query: 451 WAYGK-----DVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEED 505
+ DV E K + + + + + +Q D+ D + L Q ED
Sbjct: 1019 AILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQ--SWLSRTQTAIASED 1076
Query: 506 AAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDV-----AQSTYDYGRQLLQ 560
L+E + LL H + ++ + +K R ++ + Y + RQ LQ
Sbjct: 1077 MPNT---LTE-AEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQ 1132
Query: 561 A 561
A
Sbjct: 1133 A 1133
Score = 34.7 bits (78), Expect = 0.31
Identities = 65/325 (20%), Positives = 126/325 (38%), Gaps = 55/325 (16%)
Query: 142 TEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDEL-----ALINNGSDKGNQQEKERSV 196
++D+G LT ++ L K+ + E + ++EL AL G K +V
Sbjct: 1392 SDDYGKDLTSVNI-LLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTV 1450
Query: 197 DLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDS--- 253
F+ ++P + + H LL+ + +FN ++DE+L + M L S
Sbjct: 1451 QTKFMELLEP--LNERKHNLLASKEIHQFNRD--------VEDEILWVGERMPLATSTDH 1500
Query: 254 ----------LREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQ----LRAQ 299
+++ T +E+ + + + E Q ++ + L Q L+
Sbjct: 1501 GHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQL 1560
Query: 300 WGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQL 359
WG+ + +++H +E H Y + AA A E EL + ++
Sbjct: 1561 WGL-----LIEETEKRHRRLEEAHRAQ-QYYFD-----AAEAEAWMSEQ--ELYMMSEEK 1607
Query: 360 SDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKL 419
+ S L+ Q L QA ++ LS+ L+ AD + + +
Sbjct: 1608 AKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALV---------ADSHPESERISM 1658
Query: 420 LEEKLKSVDVGLQGLREKGQGLLDQ 444
+ K+ + GL+ L E+ +G LD+
Sbjct: 1659 RQSKVDKLYAGLKDLAEERRGKLDE 1683
Score = 31.2 bits (69), Expect = 3.4
Identities = 41/184 (22%), Positives = 78/184 (42%), Gaps = 17/184 (9%)
Query: 247 VMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQK------VMQVVNWLEGPGSEQLRAQW 300
+ K + + E + + C S+R +L + K V ++ W+E Q+ AQ
Sbjct: 1869 IQKRENEVLEAWKSLLDACE--SRRVRLVDTGDKFRFFSMVRDLMLWMEDV-IRQIEAQE 1925
Query: 301 GIGDSIRASQALQQKHEEIESQ---HSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQ 357
D + + + L H+ I+++ ++ F +EL + + A + EE +K
Sbjct: 1926 KPRD-VSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEE----IKEKLL 1980
Query: 358 QLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTL 417
QL++ + E R L+ LE H ++D S LLG + G S+ +
Sbjct: 1981 QLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVE 2040
Query: 418 KLLE 421
KL++
Sbjct: 2041 KLIK 2044
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 42.4 bits (98), Expect = 0.001
Identities = 81/439 (18%), Positives = 167/439 (38%), Gaps = 53/439 (12%)
Query: 207 ETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDE-LLAQPQVMKLLDSLREQYTRYQEVC 265
E ++ + + ELQ + S G S +D + L Q + M+LL+ L E R +
Sbjct: 1426 ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNE---RKHNLL 1482
Query: 266 RQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQ--- 322
+ +++ +++ V + L G +++ Q L +K++ ++ +
Sbjct: 1483 ASKEIHQFNRDVEDEILWVGERMP------LATSTDHGHNLQTVQLLIKKNQTLQKEIQG 1536
Query: 323 HSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALE 382
H E +Q I + + ++++Q+L+D+ +E + + E
Sbjct: 1537 HQPRIDDIFERSQNIVT------DSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEE 1590
Query: 383 FHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLL 442
H Q D A A+ +Q L ++ E+ + + +K Q L
Sbjct: 1591 AHRAQQ------------YYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILE 1638
Query: 443 DQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCE-------DMVDVRRLKMLQ 495
+ + A + T H + E + +R+ + + D+ + RR K+ +
Sbjct: 1639 QAVEDYAETVHQLSKTSRALVADSHPES--ERISMRQSKVDKLYAGLKDLAEERRGKLDE 1696
Query: 496 MVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYG 555
+LF+ + +W++E + + +H LG D + +L E+ R+F A+ T + G
Sbjct: 1697 RHRLFQLNREVDDLEQWIAE-REVVAGSH-ELGQDYEHVTMLQERFREF---ARDTGNIG 1751
Query: 556 RQLLQATVVLCQSLRCTSRSSGDTLPR----LNRVWKQFTIASEERVHRLEMAIAFHSNA 611
++ + L L + S T+ LN W + R L + H
Sbjct: 1752 QERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELH--- 1808
Query: 612 EKILQDCPEEPEAINDEEQ 630
K D E I D+ +
Sbjct: 1809 -KFYHDAKEIFGRIQDKHK 1826
Score = 34.7 bits (78), Expect = 0.31
Identities = 68/361 (18%), Positives = 137/361 (37%), Gaps = 56/361 (15%)
Query: 235 SPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVN----WLEG 290
S + E P V L + E+Y E+ R R + Q K+ + W++
Sbjct: 808 SALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWID- 866
Query: 291 PGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLV 350
EQ I + + + +Q + E +E + + + +NQ L+++G +
Sbjct: 867 -EKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE-K 924
Query: 351 ELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGV--------------------AQDL 390
E+K+ Q +L+ + ++ +++ L +AL QDL
Sbjct: 925 EIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDL 984
Query: 391 SQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQAS 450
L G++ ++Q+ L +E L +++ L L+++ + L + +QA
Sbjct: 985 GNDLAGVM-------------ALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQ 1031
Query: 451 WAYGK-----DVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEED 505
+ DV E K + + + + + +Q D+ D + L Q ED
Sbjct: 1032 AILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQ--SWLSRTQTAIASED 1089
Query: 506 AAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDV-----AQSTYDYGRQLLQ 560
L+E + LL H + ++ + +K R ++ + Y + RQ LQ
Sbjct: 1090 MPNT---LTE-AEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQ 1145
Query: 561 A 561
A
Sbjct: 1146 A 1146
Score = 34.7 bits (78), Expect = 0.31
Identities = 65/325 (20%), Positives = 126/325 (38%), Gaps = 55/325 (16%)
Query: 142 TEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDEL-----ALINNGSDKGNQQEKERSV 196
++D+G LT ++ L K+ + E + ++EL AL G K +V
Sbjct: 1405 SDDYGKDLTSVNI-LLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTV 1463
Query: 197 DLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDS--- 253
F+ ++P + + H LL+ + +FN ++DE+L + M L S
Sbjct: 1464 QTKFMELLEP--LNERKHNLLASKEIHQFNRD--------VEDEILWVGERMPLATSTDH 1513
Query: 254 ----------LREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQ----LRAQ 299
+++ T +E+ + + + E Q ++ + L Q L+
Sbjct: 1514 GHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQL 1573
Query: 300 WGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQL 359
WG+ + +++H +E H Y + AA A E EL + ++
Sbjct: 1574 WGL-----LIEETEKRHRRLEEAHRAQ-QYYFD-----AAEAEAWMSEQ--ELYMMSEEK 1620
Query: 360 SDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKL 419
+ S L+ Q L QA ++ LS+ L+ AD + + +
Sbjct: 1621 AKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALV---------ADSHPESERISM 1671
Query: 420 LEEKLKSVDVGLQGLREKGQGLLDQ 444
+ K+ + GL+ L E+ +G LD+
Sbjct: 1672 RQSKVDKLYAGLKDLAEERRGKLDE 1696
Score = 31.2 bits (69), Expect = 3.4
Identities = 41/184 (22%), Positives = 78/184 (42%), Gaps = 17/184 (9%)
Query: 247 VMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQK------VMQVVNWLEGPGSEQLRAQW 300
+ K + + E + + C S+R +L + K V ++ W+E Q+ AQ
Sbjct: 1882 IQKRENEVLEAWKSLLDACE--SRRVRLVDTGDKFRFFSMVRDLMLWMEDV-IRQIEAQE 1938
Query: 301 GIGDSIRASQALQQKHEEIESQ---HSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQ 357
D + + + L H+ I+++ ++ F +EL + + A + EE +K
Sbjct: 1939 KPRD-VSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEE----IKEKLL 1993
Query: 358 QLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTL 417
QL++ + E R L+ LE H ++D S LLG + G S+ +
Sbjct: 1994 QLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVE 2053
Query: 418 KLLE 421
KL++
Sbjct: 2054 KLIK 2057
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 42.4 bits (98), Expect = 0.001
Identities = 94/468 (20%), Positives = 183/468 (39%), Gaps = 66/468 (14%)
Query: 247 VMKLLDSLREQYTRYQEVCRQRSKRT----QLEEIQQKVMQVVNWLEGPGSEQLRAQWGI 302
V + L S++ Q+TR Q QR ++ QL+E +Q V +++ W+E G G
Sbjct: 1250 VREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG- 1308
Query: 303 GDSIRASQALQQKHEEIESQHSEWFAV--YVELNQQIAALL----NAGDEEDLVELKSLQ 356
A + + Q + E+ SE A +VE QQ+ L G E+ L+ L+
Sbjct: 1309 -----ARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLR 1363
Query: 357 QQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQT 416
+ + + + + Q Q + QD +QL+ L G L D S Q+
Sbjct: 1364 SKWEALNRKMTERGDELQQAGQQE-QLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRL 1422
Query: 417 LKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQ 476
K ++ L + + L +++ AS A+G + ++E+ Q
Sbjct: 1423 QKRHQQ-----------LESESRTLAAKMAALASMAHGMAAS----------PAILEETQ 1461
Query: 477 LRKQRCEDM---VDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQE 533
+R E + + +R L++ V+L + + + W++E H+ G
Sbjct: 1462 KHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAE--------HMPHGSPTSY 1513
Query: 534 TKV------LLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVW 587
T+ L KH++ ++ +++L + L S ++ + L W
Sbjct: 1514 TECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHW 1573
Query: 588 KQFTIASEERVHRLEMAIAFHSNAEKI--LQDCPEEPEAINDEEQFDEIEAVGKSLLDRL 645
+ A E R L+ A+ F + L+ EE + + EA L+++
Sbjct: 1574 AELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINK- 1632
Query: 646 TVPVVYPDGTEQYFGSPSDMASTAE-----NIRDRMKLVNLK-RQQLR 687
+ Y+ S ++ TA+ + ++ ++V + R+QLR
Sbjct: 1633 --HQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLR 1678
Score = 38.9 bits (89), Expect = 0.016
Identities = 108/474 (22%), Positives = 186/474 (39%), Gaps = 78/474 (16%)
Query: 202 PSVDPETVLQTGHEL---------LSELQQRR---------FNGSDGGVS-WSPMDDELL 242
P DP T+LQT L L++L++ R F S G + W LL
Sbjct: 825 PDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL 884
Query: 243 --AQPQVMKLLDSLREQYTRYQEVCRQRSKRTQL-EEIQQKVMQVVNWLEGPGS------ 293
QPQ D+L +Y+ + L E+ Q+ G +
Sbjct: 885 QRVQPQA----DTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQ 940
Query: 294 EQLRAQWGIGDSIRASQALQQKHE-EIESQHSEWFAVYVELNQQIAAL--LNAGDEEDLV 350
E+L +WG ++++ +A+Q H E+ S E V+L + L L G ED
Sbjct: 941 EELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTC 1000
Query: 351 ELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADG 410
L Q+ + V R+ + F Q+++ +E G A+ SQ L G +
Sbjct: 1001 HALQLAQKKTLVLERR---VHFLQSVV-VKVEEPGYAE--SQPLQGQV------------ 1042
Query: 411 ASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKE-NVDHIQ 469
++Q LK ++E++ Q + Q L + WA + +KE +VD
Sbjct: 1043 ETLQGLLKQVQEQVAQ-RARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVD--- 1098
Query: 470 GVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGD 529
V +L ++ +D+++ L ++ QL + A S+ + L+ LG
Sbjct: 1099 -VASAQRLLREH-QDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRV---LGQ 1153
Query: 530 DAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNR-VWK 588
QE KVL E+ ++++ +GR++ T C + + L L V +
Sbjct: 1154 QGQELKVLWEQRQQWLQEGLELQKFGREVDGFTAT------CANHQAWLHLDNLGEDVRE 1207
Query: 589 QFTIASEER-VHRL-----EMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEA 636
++ + R RL A A ++ EK++Q + P A EQ I+A
Sbjct: 1208 ALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQS--QHPAAHTVREQLQSIQA 1259
Score = 37.4 bits (85), Expect = 0.047
Identities = 76/358 (21%), Positives = 145/358 (40%), Gaps = 45/358 (12%)
Query: 303 GDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDV 362
G + + Q L +KHEE+E + A L +++ L E L+ QQ++++
Sbjct: 2358 GKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEA-AHGLRHRQQEVAES 2416
Query: 363 CYRQASQLEFRQNLLQA---ALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKL 419
++ S+ + R+ L A A + + Q+L L + AP ++ L+
Sbjct: 2417 WWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEE 2476
Query: 420 LEE---KLKSVDVGLQGLREKGQGLLDQISNQASWAYGKD---VTIENKENVDHIQGVME 473
+E +L S + R GQ LL A + D V ++ + ++G +
Sbjct: 2477 HQECKAELDSWTDSISLARSTGQQLL-----TAGHPFSSDIRQVLAGLEQELSSLEGAWQ 2531
Query: 474 DMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELL---DALLKTHIRLGDD 530
+ QL+ Q+ ++ L ++ ++ + C ++ + A E L + L + LL H L D
Sbjct: 2532 EHQLQLQQALEL--QLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWD 2589
Query: 531 AQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQF 590
+ V K A+ + G Q+ + CQ++ L R +++Q
Sbjct: 2590 LE---VQAGKISALEATARGLHQGGHPEAQSALGRCQAM----------LLRKEALFRQ- 2635
Query: 591 TIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAVGKSLLDRLTVP 648
+ R HRLE + LQD E + ++ + A+ + LLD +P
Sbjct: 2636 ---AGTRRHRLEEL----RQLQAFLQDSQEVAAWLREK----NLVALEEGLLDTAMLP 2682
Score = 35.8 bits (81), Expect = 0.14
Identities = 72/325 (22%), Positives = 134/325 (41%), Gaps = 37/325 (11%)
Query: 293 SEQLRAQWGIGDSIRA---SQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGD--EE 347
+++LRAQ + R+ ++ + ++H+E +++ W LL AG
Sbjct: 2451 AQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSS 2510
Query: 348 DLVE-LKSLQQQLSDVCYR-QASQLEFRQNL-LQAALE-FHGVAQDLSQQLDGLLGMLCV 403
D+ + L L+Q+LS + Q QL+ +Q L LQ L + + L + D L
Sbjct: 2511 DIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLW 2570
Query: 404 D-VAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENK 462
D +AP + + K+LE L+ + L +GL +A A G+
Sbjct: 2571 DPLAPMEPLLWKH--KMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGR------- 2621
Query: 463 ENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLK 522
+ M LRK+ RR ++ ++ QL +D+ + WL E K
Sbjct: 2622 ---------CQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLRE------K 2666
Query: 523 THIRLGDDAQETKVL---LEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDT 579
+ L + +T +L L+K + F ++ ++L + L Q S + +
Sbjct: 2667 NLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQER 2726
Query: 580 LPRLNRVWKQFTIASEERVHRLEMA 604
L L +W + S+++V +L+ A
Sbjct: 2727 LEELGALWGELQDNSQKKVAKLQKA 2751
Score = 34.7 bits (78), Expect = 0.31
Identities = 81/376 (21%), Positives = 145/376 (38%), Gaps = 34/376 (9%)
Query: 244 QPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIG 303
+ Q +LL + QE R+ L + + + + W++ L A G
Sbjct: 2830 EEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQE--KLPLAAAQDYG 2887
Query: 304 DSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVC 363
S+ A + LQ++H+ +ES+ S A+ + L+ AG E+ + QQL
Sbjct: 2888 QSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAG-HFAAHEVAARVQQLEKAM 2946
Query: 364 YRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEK 423
++ R+ LLQ A E +L + L V + G S + T LL +
Sbjct: 2947 AHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL-RR 3005
Query: 424 LKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCE 483
L++ L+ + ++++ A+ +E+++N + + + + +R+ E
Sbjct: 3006 LEATKRDLEAFSPR----IERLQQTAA-------LLESRKNPESPKVLAQLQAVREAHAE 3054
Query: 484 DM--VDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKH 541
+ + R + + +QL + E + WL+ A G D + KVL EK
Sbjct: 3055 LLRRAEARGHGLQEQLQLHQLERETLLLDAWLT--TKAATAESQDYGQDLEGVKVLEEKF 3112
Query: 542 RKFVDVAQSTYDYGRQLLQATVVLCQSLRCT-SRSSGDTLP-------RLNRVWKQFTIA 593
F QS L QA V + L T R + P R+ W++ A
Sbjct: 3113 DAFRKEVQS-------LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQA 3165
Query: 594 SEERVHRLEMAIAFHS 609
+ R L A HS
Sbjct: 3166 IKARTENLAAAHEVHS 3181
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 42.0 bits (97), Expect = 0.002
Identities = 106/520 (20%), Positives = 204/520 (39%), Gaps = 92/520 (17%)
Query: 251 LDSLREQYTRYQEVCRQRSKRTQLEEIQQK-VMQVVNWLEGPGSEQLRAQWGIGDSIR-- 307
L+ LR+ Y R +++ + Q EE+Q+K Q L+ E R + IR
Sbjct: 448 LNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKR 507
Query: 308 ------ASQALQQ----KHEEIESQHSEWFAVYV---ELNQQIAALLNAGDEEDLVELKS 354
A Q LQ K E++S HS+ V +L Q++ L+ + +++ + + +S
Sbjct: 508 TAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES-EQKRVNKEES 566
Query: 355 LQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADG--AS 412
LQ Q+ D+ Q L+ + + + A L+++L ++ + + AS
Sbjct: 567 LQMQVQDI-LEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLAS 625
Query: 413 IQQTLKLLEEKLKSVD----------VGLQGLREKGQGLLDQISNQASWAYGKDVTIE-N 461
+ L EE+LK + LQ L + ++ Y KD I
Sbjct: 626 ERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLL 685
Query: 462 KENVDH-IQGVMEDMQ-LRKQRCEDMVDVRRLKML--------QMVQLFKCEEDAAQAVE 511
+E + H I ME+ + L Q +V++L+ L + Q+ KC ++ + ++
Sbjct: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLK 745
Query: 512 WLSELLD--------------ALLKTHIRLGDDAQETKV----------LLEKHRKFVDV 547
+ ELL+ A+ + L + Q+ K L+E+ +K +
Sbjct: 746 TVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHE 805
Query: 548 AQSTYDYGRQLLQATVV-LCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAIA 606
+LL+A ++ + + S + L + K EE+++ ++ +
Sbjct: 806 KDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLK----GKEEQMNTMKAVLE 861
Query: 607 FH----SNAEKILQDCPEEPEAI---------------NDEEQFDEIEAVGKSLLDRLTV 647
+N K LQD EE E++ + QF+E+E V K + L
Sbjct: 862 EKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKR 921
Query: 648 PVVYPDGTEQYFGSPSDMASTAENIRDRMKLVNLKRQQLR 687
E S + + ++++D KL + +QL+
Sbjct: 922 LEAMLKERESDLSSKTQL---LQDVQDENKLFKSQIEQLK 958
Score = 30.8 bits (68), Expect = 4.4
Identities = 62/328 (18%), Positives = 132/328 (40%), Gaps = 45/328 (13%)
Query: 266 RQRSKRTQLEEIQQKVMQVVNWLEGPGSE--------QLRAQWGIGDSIRASQ------A 311
+ + + LEE ++ + WL+ E Q AQ + ++ ASQ
Sbjct: 852 QMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIV 911
Query: 312 LQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLE 371
L++K E++ + +L+ + L + DE L KS +QL Y+QAS
Sbjct: 912 LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKL--FKSQIEQLKQQNYQQASSFP 969
Query: 372 FRQNLLQAALEFHGVAQDLSQQLDGLLGML----------------CVDVAPADGASIQQ 415
+ LL+ E L +LD L + ++ + +Q
Sbjct: 970 PHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQD 1029
Query: 416 TL-KLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGV--M 472
+ K +E+ + V+ +E + L ++S ++ +YG+ + K+ + + G
Sbjct: 1030 KVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGS 1089
Query: 473 EDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQ 532
E++++ + + ++ ++ L L+ CE+ + L+E L K + +
Sbjct: 1090 EEVKVLEHKLKEADEMHTLLQLE------CEKYKSV----LAETEGILQKLQRSVEQEEN 1139
Query: 533 ETKVLLEKHRKFVDVAQSTYDYGRQLLQ 560
+ KV +++ K + QS++ Q L+
Sbjct: 1140 KWKVKVDESHKTIKQMQSSFTSSEQELE 1167
>gi|30260188 Golgi autoantigen, golgin subfamily a, 5 [Homo sapiens]
Length = 731
Score = 42.0 bits (97), Expect = 0.002
Identities = 40/157 (25%), Positives = 79/157 (50%), Gaps = 20/157 (12%)
Query: 239 DELLAQPQVMKL-LDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLR 297
DEL Q ++ KL L+S +++ Y++ K T++ + ++K++ + EG G E
Sbjct: 408 DELQQQVKLYKLNLESSKQELIDYKQ------KATRILQSKEKLINSLK--EGSGFE--- 456
Query: 298 AQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQ 357
G+ S +S L++ E E Q E + +++Q + + L + + + E +S ++
Sbjct: 457 ---GLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQ-LRSELQDMEAQQVNEAESARE 512
Query: 358 QLSD----VCYRQASQLEFRQNLLQAALEFHGVAQDL 390
QL D + ++AS+ E L + EFH + +DL
Sbjct: 513 QLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDL 549
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 41.2 bits (95), Expect = 0.003
Identities = 94/409 (22%), Positives = 167/409 (40%), Gaps = 43/409 (10%)
Query: 251 LDSLREQYTRYQEVCRQRSKRTQLEEIQQK-VMQVVNWLEGPGSEQLRAQWGIGDSIR-- 307
L+ LR+ Y R +++ + Q EE+Q+K Q L+ E R + IR
Sbjct: 448 LNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKR 507
Query: 308 ------ASQALQQ----KHEEIESQHSEWFAVYV---ELNQQIAALLNAGDEEDLVELKS 354
A Q LQ K E++S HS+ V +L Q++ L+ + +++ + + +S
Sbjct: 508 TAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES-EQKRVNKEES 566
Query: 355 LQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADG--AS 412
LQ Q+ D+ Q L+ + + + A L+++L ++ + + AS
Sbjct: 567 LQMQVQDI-LEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLAS 625
Query: 413 IQQTLKLLEEKLKSVD----------VGLQGLREKGQGLLDQISNQASWAYGKDVTIE-N 461
+ L EE+LK + LQ L + ++ Y KD I
Sbjct: 626 ERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLL 685
Query: 462 KENVDH-IQGVMEDMQ-LRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDA 519
+E + H I ME+ + L Q +V++L+ L Q K D + +E + D
Sbjct: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK---DVVEQMEKCIQEKDE 742
Query: 520 LLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDT 579
LKT L + E+ + S+ Q L+A Q+ + + S +
Sbjct: 743 KLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----QNDQVSFASLVEE 798
Query: 580 LPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDE 628
L ++ K I S E + LE + +N EK +QD +E +A+ +E
Sbjct: 799 LKKVIHE-KDGKIKSVEEL--LEAELLKVANKEKTVQDLKQEIKALKEE 844
Score = 30.8 bits (68), Expect = 4.4
Identities = 62/328 (18%), Positives = 132/328 (40%), Gaps = 45/328 (13%)
Query: 266 RQRSKRTQLEEIQQKVMQVVNWLEGPGSE--------QLRAQWGIGDSIRASQ------A 311
+ + + LEE ++ + WL+ E Q AQ + ++ ASQ
Sbjct: 875 QMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIV 934
Query: 312 LQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLE 371
L++K E++ + +L+ + L + DE L KS +QL Y+QAS
Sbjct: 935 LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKL--FKSQIEQLKQQNYQQASSFP 992
Query: 372 FRQNLLQAALEFHGVAQDLSQQLDGLLGML----------------CVDVAPADGASIQQ 415
+ LL+ E L +LD L + ++ + +Q
Sbjct: 993 PHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQD 1052
Query: 416 TL-KLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGV--M 472
+ K +E+ + V+ +E + L ++S ++ +YG+ + K+ + + G
Sbjct: 1053 KVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGS 1112
Query: 473 EDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQ 532
E++++ + + ++ ++ L L+ CE+ + L+E L K + +
Sbjct: 1113 EEVKVLEHKLKEADEMHTLLQLE------CEKYKSV----LAETEGILQKLQRSVEQEEN 1162
Query: 533 ETKVLLEKHRKFVDVAQSTYDYGRQLLQ 560
+ KV +++ K + QS++ Q L+
Sbjct: 1163 KWKVKVDESHKTIKQMQSSFTSSEQELE 1190
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,715,842
Number of Sequences: 37866
Number of extensions: 1047885
Number of successful extensions: 3758
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 175
Number of HSP's that attempted gapping in prelim test: 3381
Number of HSP's gapped (non-prelim): 506
length of query: 696
length of database: 18,247,518
effective HSP length: 109
effective length of query: 587
effective length of database: 14,120,124
effective search space: 8288512788
effective search space used: 8288512788
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.