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Search of human proteins with 187608577
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1
[Homo sapiens]
(480 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1 [... 957 0.0
gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1 [... 957 0.0
gi|187608585 CASP8 and FADD-like apoptosis regulator isoform 2 [... 392 e-109
gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 139 7e-33
gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 139 7e-33
gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 134 1e-31
gi|15718708 caspase 8 isoform C precursor [Homo sapiens] 134 1e-31
gi|15718704 caspase 8 isoform A precursor [Homo sapiens] 119 6e-27
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 110 3e-24
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 108 1e-23
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 104 2e-22
gi|15718712 caspase 8 isoform E [Homo sapiens] 72 1e-12
gi|14790115 caspase 3 preproprotein [Homo sapiens] 66 8e-11
gi|14790119 caspase 3 preproprotein [Homo sapiens] 66 8e-11
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 65 1e-10
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens] 65 2e-10
gi|15718698 caspase 7 isoform delta [Homo sapiens] 61 2e-09
gi|15718700 caspase 7 isoform alpha [Homo sapiens] 61 2e-09
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 61 2e-09
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 50 6e-06
gi|14916485 caspase 6 isoform beta [Homo sapiens] 50 6e-06
gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 46 9e-05
gi|209870075 caspase 5 isoform d [Homo sapiens] 46 9e-05
gi|209870073 caspase 5 isoform c [Homo sapiens] 46 9e-05
gi|209870071 caspase 5 isoform b precursor [Homo sapiens] 46 9e-05
gi|209870069 caspase 5 isoform a precursor [Homo sapiens] 46 9e-05
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 44 2e-04
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 44 2e-04
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 44 2e-04
gi|15431332 caspase 1 isoform delta [Homo sapiens] 44 2e-04
>gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1
[Homo sapiens]
Length = 480
Score = 957 bits (2473), Expect = 0.0
Identities = 480/480 (100%), Positives = 480/480 (100%)
Query: 1 MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLY 60
MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLY
Sbjct: 1 MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLY 60
Query: 61 RVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYM 120
RVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYM
Sbjct: 61 RVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYM 120
Query: 121 GRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGT 180
GRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGT
Sbjct: 121 GRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGT 180
Query: 181 SYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIP 240
SYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIP
Sbjct: 181 SYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIP 240
Query: 241 EERYKMKSKPLGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMP 300
EERYKMKSKPLGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMP
Sbjct: 241 EERYKMKSKPLGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMP 300
Query: 301 EHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNY 360
EHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNY
Sbjct: 301 EHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNY 360
Query: 361 VVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSP 420
VVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSP
Sbjct: 361 VVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSP 420
Query: 421 SLYLQCLSQKLRQERKRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT 480
SLYLQCLSQKLRQERKRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT
Sbjct: 421 SLYLQCLSQKLRQERKRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT 480
>gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1
[Homo sapiens]
Length = 480
Score = 957 bits (2473), Expect = 0.0
Identities = 480/480 (100%), Positives = 480/480 (100%)
Query: 1 MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLY 60
MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLY
Sbjct: 1 MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLY 60
Query: 61 RVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYM 120
RVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYM
Sbjct: 61 RVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYM 120
Query: 121 GRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGT 180
GRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGT
Sbjct: 121 GRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGT 180
Query: 181 SYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIP 240
SYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIP
Sbjct: 181 SYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIP 240
Query: 241 EERYKMKSKPLGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMP 300
EERYKMKSKPLGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMP
Sbjct: 241 EERYKMKSKPLGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMP 300
Query: 301 EHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNY 360
EHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNY
Sbjct: 301 EHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNY 360
Query: 361 VVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSP 420
VVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSP
Sbjct: 361 VVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSP 420
Query: 421 SLYLQCLSQKLRQERKRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT 480
SLYLQCLSQKLRQERKRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT
Sbjct: 421 SLYLQCLSQKLRQERKRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT 480
>gi|187608585 CASP8 and FADD-like apoptosis regulator isoform 2
[Homo sapiens]
Length = 221
Score = 392 bits (1007), Expect = e-109
Identities = 202/203 (99%), Positives = 203/203 (100%)
Query: 1 MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLY 60
MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLY
Sbjct: 1 MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLY 60
Query: 61 RVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYM 120
RVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYM
Sbjct: 61 RVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYM 120
Query: 121 GRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGT 180
GRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGT
Sbjct: 121 GRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGT 180
Query: 181 SYRNVLQAAIQKSLKDPSNNFRL 203
SYRNVLQAAIQKSLKDPSNNFR+
Sbjct: 181 SYRNVLQAAIQKSLKDPSNNFRM 203
>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
Length = 538
Score = 139 bits (349), Expect = 7e-33
Identities = 131/503 (26%), Positives = 233/503 (46%), Gaps = 66/503 (13%)
Query: 6 IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59
++ + E LD+++ L FL D ++D L + L+E+ L +L+ ELL
Sbjct: 66 LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 125
Query: 60 YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118
+R+ R DLL L ++ +E L +S YRV++ +I E++ +S++ S FL+++
Sbjct: 126 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 185
Query: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178
+ + K+ + + LD+ +E+EK ++ +LD+L++ I++ LK I Y++
Sbjct: 186 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEE----- 239
Query: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238
+ ++++ S + SN +E G Q+SE+ Q+
Sbjct: 240 ---FSKERSSSLEGSPDEFSNG-------------EELCGVMTISDSPREQDSES---QT 280
Query: 239 IPEERYKMKSKPLGICLIIDCIG-----------------NETEL----LRDTFTSLGYE 277
+ ++ Y+MKSKP G CLII+ N T L L TF L +E
Sbjct: 281 L-DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 339
Query: 278 VQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIR 337
++ ++ I +IL + M +H + D F+C ++S G +YG D + P++ +
Sbjct: 340 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEA--PIYELT 396
Query: 338 RMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHR 397
F G CP LAGKPK+FFIQ + +E D +E +
Sbjct: 397 SQFTGLKCPSLAGKPKVFFIQ--ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPD 454
Query: 398 EADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNS 455
EADF + T + + ++ + + Y+Q L Q LR+ R +L + E+N Y+ ++
Sbjct: 455 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN---YEVSN 511
Query: 456 RVSAKE--KYYVWLQHTLRKKLI 476
+ K K TLRKKL+
Sbjct: 512 KDDKKNMGKQMPQPTFTLRKKLV 534
>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
Length = 479
Score = 139 bits (349), Expect = 7e-33
Identities = 131/503 (26%), Positives = 233/503 (46%), Gaps = 66/503 (13%)
Query: 6 IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59
++ + E LD+++ L FL D ++D L + L+E+ L +L+ ELL
Sbjct: 7 LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
Query: 60 YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118
+R+ R DLL L ++ +E L +S YRV++ +I E++ +S++ S FL+++
Sbjct: 67 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
Query: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178
+ + K+ + + LD+ +E+EK ++ +LD+L++ I++ LK I Y++
Sbjct: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEE----- 180
Query: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238
+ ++++ S + SN +E G Q+SE+ Q+
Sbjct: 181 ---FSKERSSSLEGSPDEFSNG-------------EELCGVMTISDSPREQDSES---QT 221
Query: 239 IPEERYKMKSKPLGICLIIDCIG-----------------NETEL----LRDTFTSLGYE 277
+ ++ Y+MKSKP G CLII+ N T L L TF L +E
Sbjct: 222 L-DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 280
Query: 278 VQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIR 337
++ ++ I +IL + M +H + D F+C ++S G +YG D + P++ +
Sbjct: 281 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEA--PIYELT 337
Query: 338 RMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHR 397
F G CP LAGKPK+FFIQ + +E D +E +
Sbjct: 338 SQFTGLKCPSLAGKPKVFFIQ--ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPD 395
Query: 398 EADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNS 455
EADF + T + + ++ + + Y+Q L Q LR+ R +L + E+N Y+ ++
Sbjct: 396 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN---YEVSN 452
Query: 456 RVSAKE--KYYVWLQHTLRKKLI 476
+ K K TLRKKL+
Sbjct: 453 KDDKKNMGKQMPQPTFTLRKKLV 475
>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 134 bits (338), Expect = 1e-31
Identities = 129/503 (25%), Positives = 226/503 (44%), Gaps = 81/503 (16%)
Query: 6 IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59
++ + E LD+++ L FL D ++D L + L+E+ L +L+ ELL
Sbjct: 7 LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
Query: 60 YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118
+R+ R DLL L ++ +E L +S YRV++ +I E++ +S++ S FL+++
Sbjct: 67 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
Query: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178
+ + K+ + + LD+ +E+EK ++ +LD+L++ I++ LK I Y++ +G
Sbjct: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKG- 184
Query: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238
+E G Q+SE+ Q+
Sbjct: 185 -----------------------------------EELCGVMTISDSPREQDSES---QT 206
Query: 239 IPEERYKMKSKPLGICLIIDCIG-----------------NETEL----LRDTFTSLGYE 277
+ ++ Y+MKSKP G CLII+ N T L L TF L +E
Sbjct: 207 L-DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
Query: 278 VQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIR 337
++ ++ I +IL + M +H + D F+C ++S G +YG D + P++ +
Sbjct: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEA--PIYELT 322
Query: 338 RMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHR 397
F G CP LAGKPK+FFIQ + +E D +E +
Sbjct: 323 SQFTGLKCPSLAGKPKVFFIQ--ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPD 380
Query: 398 EADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNS 455
EADF + T + + ++ + + Y+Q L Q LR+ R +L + E+N Y+ ++
Sbjct: 381 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN---YEVSN 437
Query: 456 RVSAKE--KYYVWLQHTLRKKLI 476
+ K K TLRKKL+
Sbjct: 438 KDDKKNMGKQMPQPTFTLRKKLV 460
>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 134 bits (338), Expect = 1e-31
Identities = 129/503 (25%), Positives = 226/503 (44%), Gaps = 81/503 (16%)
Query: 6 IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59
++ + E LD+++ L FL D ++D L + L+E+ L +L+ ELL
Sbjct: 7 LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
Query: 60 YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118
+R+ R DLL L ++ +E L +S YRV++ +I E++ +S++ S FL+++
Sbjct: 67 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
Query: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178
+ + K+ + + LD+ +E+EK ++ +LD+L++ I++ LK I Y++ +G
Sbjct: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKG- 184
Query: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238
+E G Q+SE+ Q+
Sbjct: 185 -----------------------------------EELCGVMTISDSPREQDSES---QT 206
Query: 239 IPEERYKMKSKPLGICLIIDCIG-----------------NETEL----LRDTFTSLGYE 277
+ ++ Y+MKSKP G CLII+ N T L L TF L +E
Sbjct: 207 L-DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
Query: 278 VQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIR 337
++ ++ I +IL + M +H + D F+C ++S G +YG D + P++ +
Sbjct: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEA--PIYELT 322
Query: 338 RMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHR 397
F G CP LAGKPK+FFIQ + +E D +E +
Sbjct: 323 SQFTGLKCPSLAGKPKVFFIQ--ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPD 380
Query: 398 EADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNS 455
EADF + T + + ++ + + Y+Q L Q LR+ R +L + E+N Y+ ++
Sbjct: 381 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN---YEVSN 437
Query: 456 RVSAKE--KYYVWLQHTLRKKLI 476
+ K K TLRKKL+
Sbjct: 438 KDDKKNMGKQMPQPTFTLRKKLV 460
>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
Length = 496
Score = 119 bits (298), Expect = 6e-27
Identities = 130/537 (24%), Positives = 227/537 (42%), Gaps = 117/537 (21%)
Query: 6 IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59
++ + E LD+++ L FL D ++D L + L+E+ L +L+ ELL
Sbjct: 7 LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
Query: 60 YRVRRFDLLKRILKMDRKAVETHLL----------------------------------- 84
+R+ R DLL L ++ +E L
Sbjct: 67 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWR 126
Query: 85 RNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLV 144
R HL+ RV++ +I E++ +S++ S FL+++ + + K+ + + LD+ +E+EK ++
Sbjct: 127 RVDHLL--IRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVIL 184
Query: 145 APDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPSNNFRLH 204
+LD+L++ I++ LK I Y++ +G
Sbjct: 185 GEGKLDILKRVCAQINKSLLKI-INDYEEFSKG--------------------------- 216
Query: 205 NGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIPEERYKMKSKPLGICLIIDCIG--- 261
+E G Q+SE+ Q++ ++ Y+MKSKP G CLII+
Sbjct: 217 ---------EELCGVMTISDSPREQDSES---QTL-DKVYQMKSKPRGYCLIINNHNFAK 263
Query: 262 --------------NETEL----LRDTFTSLGYEVQKFLHLSMHGISQILGQFACMPEHR 303
N T L L TF L +E++ ++ I +IL + M +H
Sbjct: 264 AREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLM-DHS 322
Query: 304 DYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVS 363
+ D F+C ++S G +YG D + P++ + F G CP LAGKPK+FFIQ
Sbjct: 323 NMDCFICCILSHGDKGIIYGTDGQEA--PIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQ 378
Query: 364 EGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLY 423
+ +E D +E + EADF + T + + ++ + + Y
Sbjct: 379 GDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWY 438
Query: 424 LQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNSRVSAKE--KYYVWLQHTLRKKLI 476
+Q L Q LR+ R +L + E+N Y+ +++ K K TLRKKL+
Sbjct: 439 IQSLCQSLRERCPRGDDILTILTEVN---YEVSNKDDKKNMGKQMPQPTFTLRKKLV 492
Score = 44.3 bits (103), Expect = 2e-04
Identities = 35/136 (25%), Positives = 58/136 (42%), Gaps = 18/136 (13%)
Query: 92 DYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDL 151
D+ + +IGE LD D++SL FL DY+ + K K L L L++ ++ L
Sbjct: 2 DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF 61
Query: 152 LEKCLKNIHRIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPS----NNFRLHNGR 207
L++ L I+R+DL +Y N + +++ L+ P + +R H R
Sbjct: 62 LKELLFRINRLDLL--------------ITYLNTRKEEMERELQTPGRAQISAYRFHFCR 107
Query: 208 SKEQRLKEQLGAQQEP 223
Q Q P
Sbjct: 108 MSWAEANSQCQTQSVP 123
>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
Length = 522
Score = 110 bits (275), Expect = 3e-24
Identities = 138/516 (26%), Positives = 217/516 (42%), Gaps = 78/516 (15%)
Query: 9 VEEALDTDEKEMLLFLCRDVAIDVVP-------PNVRDLLDILRERGKLSVGD---LAEL 58
++ L + E L FLC I +VP + D+ + L LS D LAEL
Sbjct: 27 IDSNLGVQDVENLKFLC----IGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAEL 82
Query: 59 LYRVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118
LY +R+ LL+ L ++ VE LL VS +R L+ E+ E +D ++ +IFL+KD
Sbjct: 83 LYIIRQKKLLQH-LNCTKEEVE-RLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKD 140
Query: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLE--------KCLKNIHRIDLKTKIQ- 169
+ + E + L + LEK + D L LE K L+NI + + IQ
Sbjct: 141 SLPK----TEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQI 196
Query: 170 ------KYKQSVQG-----AGTSYRNVLQAAIQKSLKDP---SNNFRLHNGRSKEQRLKE 215
K +S QG + T + L+A Q+S ++ SN R NG
Sbjct: 197 VTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGM 256
Query: 216 QLGAQQEPVKKSIQESEAFLPQSIPEERYKMKSKPLGICLIIDCIG-----------NET 264
Q GA + A + Y+M G+C+I++ +
Sbjct: 257 Q-GASANTLNSETSTKRAAV--------YRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDA 307
Query: 265 ELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGV 324
E+L F LG+ V +++ + +L + C P H D D FV +++ G +VY
Sbjct: 308 EILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSS 367
Query: 325 DQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVE 384
D+ + +P+ I F CP LA KPK+FFIQ +++ S +E D +
Sbjct: 368 DE--ALIPIREIMSHFTALQCPRLAEKPKLFFIQ--ACQGEEIQPSVSIEADALNPEQAP 423
Query: 385 FKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQ--ERKRPLLDL 442
Q ++ EADF L T + + S Y+Q L L++ R +L +
Sbjct: 424 TSLQD----SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSI 479
Query: 443 HIELNGYMYDWNSRVSAK--EKYYVWLQHTLRKKLI 476
+N D + RV + +K TLRKKL+
Sbjct: 480 LTAVND---DVSRRVDKQGTKKQMPQPAFTLRKKLV 512
>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
Length = 521
Score = 108 bits (269), Expect = 1e-23
Identities = 129/486 (26%), Positives = 204/486 (41%), Gaps = 73/486 (15%)
Query: 9 VEEALDTDEKEMLLFLCRDVAIDVVP-------PNVRDLLDILRERGKLSVGD---LAEL 58
++ L + E L FLC I +VP + D+ + L LS D LAEL
Sbjct: 27 IDSNLGVQDVENLKFLC----IGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAEL 82
Query: 59 LYRVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118
LY +R+ LL+ L ++ VE LL VS +R L+ E+ E +D ++ +IFL+KD
Sbjct: 83 LYIIRQKKLLQH-LNCTKEEVE-RLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKD 140
Query: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLE--------KCLKNIHRIDLKTKIQ- 169
+ + E + L + LEK + D L LE K L+NI + + IQ
Sbjct: 141 SLPK----TEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQI 196
Query: 170 ------KYKQSVQG-----AGTSYRNVLQAAIQKSLKDP---SNNFRLHNGRSKEQRLKE 215
K +S QG + T + L+A Q+S ++ SN R NG
Sbjct: 197 VTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGM 256
Query: 216 QLGAQQEPVKKSIQESEAFLPQSIPEERYKMKSKPLGICLIIDCIG-----------NET 264
Q GA + A + Y+M G+C+I++ +
Sbjct: 257 Q-GASANTLNSETSTKRAAV--------YRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDA 307
Query: 265 ELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGV 324
E+L F LG+ V +++ + +L + C P H D D FV +++ G +VY
Sbjct: 308 EILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSS 367
Query: 325 DQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVE 384
D+ + +P+ I F CP LA KPK+FFIQ +++ S +E D +
Sbjct: 368 DE--ALIPIREIMSHFTALQCPRLAEKPKLFFIQ--ACQGEEIQPSVSIEADALNPEQAP 423
Query: 385 FKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQ--ERKRPLLDL 442
Q ++ EADF L T + + S Y+Q L L++ R L+
Sbjct: 424 TSLQD----SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEK 479
Query: 443 HIELNG 448
+E+ G
Sbjct: 480 TMEIRG 485
>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
Length = 479
Score = 104 bits (260), Expect = 2e-22
Identities = 131/493 (26%), Positives = 211/493 (42%), Gaps = 75/493 (15%)
Query: 9 VEEALDTDEKEMLLFLCRDVAIDVVP-------PNVRDLLDILRERGKLSVGD---LAEL 58
++ L + E L FLC I +VP + D+ + L LS D LAEL
Sbjct: 27 IDSNLGVQDVENLKFLC----IGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAEL 82
Query: 59 LYRVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118
LY +R+ LL+ L ++ VE LL VS +R L+ E+ E +D ++ +IFL+KD
Sbjct: 83 LYIIRQKKLLQH-LNCTKEEVE-RLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKD 140
Query: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178
+ + E + L + LEK + D L LE K + L I+KYK+
Sbjct: 141 SLPK----TEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVP-KLLRNIEKYKR----- 190
Query: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238
+ AIQ + G +E+L +Q + VK ++ LP++
Sbjct: 191 --------EKAIQIVTPPVDKEAESYQG-------EEELVSQTD-VKTFLEA----LPRA 230
Query: 239 IPEERYKMKSKPLGICLIIDCIG-----------NETELLRDTFTSLGYEVQKFLHLSMH 287
Y+M G+C+I++ + E+L F LG+ V +++
Sbjct: 231 AV---YRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKV 287
Query: 288 GISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPY 347
+ +L + C P H D D FV +++ G +VY D+ + +P+ I F CP
Sbjct: 288 EMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDE--ALIPIREIMSHFTALQCPR 345
Query: 348 LAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCT 407
LA KPK+FFIQ +++ S +E D + Q ++ EADF L T
Sbjct: 346 LAEKPKLFFIQ--ACQGEEIQPSVSIEADALNPEQAPTSLQD----SIPAEADFLLGLAT 399
Query: 408 ADMSLLEQSHSSPSLYLQCLSQKLRQ--ERKRPLLDLHIELNGYMYDWNSRVSAK--EKY 463
+ + S Y+Q L L++ R +L + +N D + RV + +K
Sbjct: 400 VPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVND---DVSRRVDKQGTKKQ 456
Query: 464 YVWLQHTLRKKLI 476
TLRKKL+
Sbjct: 457 MPQPAFTLRKKLV 469
>gi|15718712 caspase 8 isoform E [Homo sapiens]
Length = 235
Score = 72.0 bits (175), Expect = 1e-12
Identities = 51/193 (26%), Positives = 103/193 (53%), Gaps = 15/193 (7%)
Query: 6 IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59
++ + E LD+++ L FL D ++D L + L+E+ L +L+ ELL
Sbjct: 7 LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
Query: 60 YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118
+R+ R DLL L ++ +E L +S YRV++ +I E++ +S++ S FL+++
Sbjct: 67 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
Query: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQ----- 173
+ + K+ + + LD+ +E+EK ++ +LD+L++ I++ LK I Y++
Sbjct: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKER 185
Query: 174 --SVQGAGTSYRN 184
S++G+ + N
Sbjct: 186 SSSLEGSPDEFSN 198
Score = 45.1 bits (105), Expect = 1e-04
Identities = 32/120 (26%), Positives = 61/120 (50%), Gaps = 9/120 (7%)
Query: 92 DYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDL 151
D+ + +IGE LD D++SL FL DY+ + K K L L L++ ++ L
Sbjct: 2 DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF 61
Query: 152 LEKCLKNIHRID-----LKTKIQKYKQSVQGAG----TSYRNVLQAAIQKSLKDPSNNFR 202
L++ L I+R+D L T+ ++ ++ +Q G ++YR +L ++ + +F+
Sbjct: 62 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFK 121
>gi|14790115 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 65.9 bits (159), Expect = 8e-11
Identities = 63/224 (28%), Positives = 98/224 (43%), Gaps = 33/224 (14%)
Query: 226 KSIQESEAFLPQSIPEERYKMKSKPLGICLIIDC------------IGNETEL--LRDTF 271
K I SE+ + YKM +G+C+II+ G + + LR+TF
Sbjct: 19 KIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETF 78
Query: 272 TSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGL 331
+L YEV+ L+ I +++ + +H SFVCVL+S G ++G T+ +
Sbjct: 79 RNLKYEVRNKNDLTREEIVELMRDVS-KEDHSKRSSFVCVLLSHGEEGIIFG---TNGPV 134
Query: 332 PLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQ--LEDSSLLEVDGPAMKNVEFKAQK 389
L I F GD C L GKPK+F IQ +E +E S ++ D K
Sbjct: 135 DLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHK-------- 186
Query: 390 RGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQ 433
+ EADF ++ TA ++ S ++Q L L+Q
Sbjct: 187 -----IPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQ 225
>gi|14790119 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 65.9 bits (159), Expect = 8e-11
Identities = 63/224 (28%), Positives = 98/224 (43%), Gaps = 33/224 (14%)
Query: 226 KSIQESEAFLPQSIPEERYKMKSKPLGICLIIDC------------IGNETEL--LRDTF 271
K I SE+ + YKM +G+C+II+ G + + LR+TF
Sbjct: 19 KIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETF 78
Query: 272 TSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGL 331
+L YEV+ L+ I +++ + +H SFVCVL+S G ++G T+ +
Sbjct: 79 RNLKYEVRNKNDLTREEIVELMRDVS-KEDHSKRSSFVCVLLSHGEEGIIFG---TNGPV 134
Query: 332 PLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQ--LEDSSLLEVDGPAMKNVEFKAQK 389
L I F GD C L GKPK+F IQ +E +E S ++ D K
Sbjct: 135 DLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHK-------- 186
Query: 390 RGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQ 433
+ EADF ++ TA ++ S ++Q L L+Q
Sbjct: 187 -----IPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQ 225
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 65.5 bits (158), Expect = 1e-10
Identities = 47/148 (31%), Positives = 70/148 (47%), Gaps = 19/148 (12%)
Query: 244 YKMKSKPLGICLIIDCIG--NETEL------------LRDTFTSLGYEVQKFLHLSMHGI 289
Y+++S+P G+ L++ + E EL L F LGY+V + +
Sbjct: 192 YRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEM 251
Query: 290 SQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLA 349
+ L FA +P HR DS + L+S G ++YGVD L L + ++F +CP L
Sbjct: 252 QEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVD--GKLLQLQEVFQLFDNANCPSLQ 309
Query: 350 GKPKMFFIQNYVVSEGQLEDSSLLEVDG 377
KPKMFFIQ G D + + DG
Sbjct: 310 NKPKMFFIQ---ACRGDETDRGVDQQDG 334
>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
Length = 293
Score = 64.7 bits (156), Expect = 2e-10
Identities = 62/235 (26%), Positives = 100/235 (42%), Gaps = 42/235 (17%)
Query: 225 KKSIQESEAFLPQSI--PEERYKMKSKPLGICLIID----------------CIGNETEL 266
++++ E++AF + + P E+YKM + GI LI + C +
Sbjct: 16 EENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDN-- 73
Query: 267 LRDTFTSLGYEVQKF-------LHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQ 319
L F+ LG+EV+ F L L +H +S + H D D FVCV +S G
Sbjct: 74 LTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTV--------SHADADCFVCVFLSHGEGN 125
Query: 320 SVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPA 379
+Y D + + + + +F GD C L GKPK+F IQ ++ + L VD
Sbjct: 126 HIYAYD---AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQT 182
Query: 380 MK---NVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKL 431
K N+ + + T+ ADF A+ + + S Y+Q L + L
Sbjct: 183 EKLDTNIT-EVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML 236
>gi|15718698 caspase 7 isoform delta [Homo sapiens]
Length = 336
Score = 61.2 bits (147), Expect = 2e-09
Identities = 54/212 (25%), Positives = 90/212 (42%), Gaps = 26/212 (12%)
Query: 239 IPEERYKMKSKPLGICLIIDC--------------IGNETELLRDTFTSLGYEVQKFLHL 284
+P +Y M + LG C+II+ + E L F SLG++V +
Sbjct: 88 VPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDC 147
Query: 285 SMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDS 344
S + +L + A +H + F C+L+S G +YG D P+ + F GD
Sbjct: 148 SCAKMQDLLKK-ASEEDHTNAACFACILLSHGEENVIYGKDGV---TPIKDLTAHFRGDR 203
Query: 345 CPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWS 404
C L KPK+FFIQ +L+D ++ D + + + + + + EADF ++
Sbjct: 204 CKTLLEKPKLFFIQ--ACRGTELDDG--IQADSGPINDTDANPRYK----IPVEADFLFA 255
Query: 405 LCTADMSLLEQSHSSPSLYLQCLSQKLRQERK 436
T +S S ++Q L L + K
Sbjct: 256 YSTVPGYYSWRSPGRGSWFVQALCSILEEHGK 287
>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
Length = 303
Score = 61.2 bits (147), Expect = 2e-09
Identities = 54/212 (25%), Positives = 90/212 (42%), Gaps = 26/212 (12%)
Query: 239 IPEERYKMKSKPLGICLIIDC--------------IGNETELLRDTFTSLGYEVQKFLHL 284
+P +Y M + LG C+II+ + E L F SLG++V +
Sbjct: 55 VPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDC 114
Query: 285 SMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDS 344
S + +L + A +H + F C+L+S G +YG D P+ + F GD
Sbjct: 115 SCAKMQDLLKK-ASEEDHTNAACFACILLSHGEENVIYGKDGV---TPIKDLTAHFRGDR 170
Query: 345 CPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWS 404
C L KPK+FFIQ +L+D ++ D + + + + + + EADF ++
Sbjct: 171 CKTLLEKPKLFFIQ--ACRGTELDDG--IQADSGPINDTDANPRYK----IPVEADFLFA 222
Query: 405 LCTADMSLLEQSHSSPSLYLQCLSQKLRQERK 436
T +S S ++Q L L + K
Sbjct: 223 YSTVPGYYSWRSPGRGSWFVQALCSILEEHGK 254
>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
Length = 303
Score = 61.2 bits (147), Expect = 2e-09
Identities = 54/212 (25%), Positives = 90/212 (42%), Gaps = 26/212 (12%)
Query: 239 IPEERYKMKSKPLGICLIIDC--------------IGNETELLRDTFTSLGYEVQKFLHL 284
+P +Y M + LG C+II+ + E L F SLG++V +
Sbjct: 55 VPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDC 114
Query: 285 SMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDS 344
S + +L + A +H + F C+L+S G +YG D P+ + F GD
Sbjct: 115 SCAKMQDLLKK-ASEEDHTNAACFACILLSHGEENVIYGKDGV---TPIKDLTAHFRGDR 170
Query: 345 CPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWS 404
C L KPK+FFIQ +L+D ++ D + + + + + + EADF ++
Sbjct: 171 CKTLLEKPKLFFIQ--ACRGTELDDG--IQADSGPINDTDANPRYK----IPVEADFLFA 222
Query: 405 LCTADMSLLEQSHSSPSLYLQCLSQKLRQERK 436
T +S S ++Q L L + K
Sbjct: 223 YSTVPGYYSWRSPGRGSWFVQALCSILEEHGK 254
>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
Length = 416
Score = 49.7 bits (117), Expect = 6e-06
Identities = 42/137 (30%), Positives = 61/137 (44%), Gaps = 26/137 (18%)
Query: 244 YKMKSKPLGICLIIDCIG--NETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFAC--- 298
Y + +P G CLII+ + E+ L T +++ E + S+H + ++ G
Sbjct: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212
Query: 299 --------MPEHRDYDSFVCVLVSRGGSQS-------VYGVDQTHSGLPL--HHIRRMFM 341
+H D V V++S G S VYG D G P+ I +F
Sbjct: 213 VLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTD----GCPVSVEKIVNIFN 268
Query: 342 GDSCPYLAGKPKMFFIQ 358
G SCP L GKPK+FFIQ
Sbjct: 269 GTSCPSLGGKPKLFFIQ 285
>gi|14916485 caspase 6 isoform beta [Homo sapiens]
Length = 204
Score = 49.7 bits (117), Expect = 6e-06
Identities = 38/133 (28%), Positives = 58/133 (43%), Gaps = 7/133 (5%)
Query: 302 HRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYV 361
H D D FVCV +S G +Y D + + + + +F GD C L GKPK+F IQ
Sbjct: 19 HADADCFVCVFLSHGEGNHIYAYD---AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACR 75
Query: 362 VSEGQLEDSSLLEVDGPAMK---NVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHS 418
++ + L VD K N+ + + T+ ADF A+ +
Sbjct: 76 GNQHDVPVIPLDVVDNQTEKLDTNIT-EVDAASVYTLPAGADFLMCYSVAEGYYSHRETV 134
Query: 419 SPSLYLQCLSQKL 431
+ S Y+Q L + L
Sbjct: 135 NGSWYIQDLCEML 147
>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
Length = 447
Score = 45.8 bits (107), Expect = 9e-05
Identities = 38/136 (27%), Positives = 61/136 (44%), Gaps = 12/136 (8%)
Query: 274 LGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGV---DQTHSG 330
LGY V +L+ + +L FA PEH+ DS VL+S G + + G +
Sbjct: 239 LGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDV 298
Query: 331 LPLHHIRRMFMGDSCPYLAGKPKMFFIQN-YVVSEGQL----EDSSLLEVDGPAMKNVEF 385
L I ++F +C L KPK+ +Q G+L +SL + + +N+E
Sbjct: 299 LLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEA 358
Query: 386 KAQKRGLCTVHREADF 401
+ +C +H E DF
Sbjct: 359 DS----VCKIHEEKDF 370
>gi|209870075 caspase 5 isoform d [Homo sapiens]
Length = 216
Score = 45.8 bits (107), Expect = 9e-05
Identities = 38/136 (27%), Positives = 61/136 (44%), Gaps = 12/136 (8%)
Query: 274 LGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGV---DQTHSG 330
LGY V +L+ + +L FA PEH+ DS VL+S G + + G +
Sbjct: 8 LGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDV 67
Query: 331 LPLHHIRRMFMGDSCPYLAGKPKMFFIQN-YVVSEGQL----EDSSLLEVDGPAMKNVEF 385
L I ++F +C L KPK+ +Q G+L +SL + + +N+E
Sbjct: 68 LLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEA 127
Query: 386 KAQKRGLCTVHREADF 401
+ +C +H E DF
Sbjct: 128 DS----VCKIHEEKDF 139
>gi|209870073 caspase 5 isoform c [Homo sapiens]
Length = 292
Score = 45.8 bits (107), Expect = 9e-05
Identities = 38/136 (27%), Positives = 61/136 (44%), Gaps = 12/136 (8%)
Query: 274 LGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGV---DQTHSG 330
LGY V +L+ + +L FA PEH+ DS VL+S G + + G +
Sbjct: 84 LGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDV 143
Query: 331 LPLHHIRRMFMGDSCPYLAGKPKMFFIQN-YVVSEGQL----EDSSLLEVDGPAMKNVEF 385
L I ++F +C L KPK+ +Q G+L +SL + + +N+E
Sbjct: 144 LLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEA 203
Query: 386 KAQKRGLCTVHREADF 401
+ +C +H E DF
Sbjct: 204 DS----VCKIHEEKDF 215
>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
Length = 376
Score = 45.8 bits (107), Expect = 9e-05
Identities = 38/136 (27%), Positives = 61/136 (44%), Gaps = 12/136 (8%)
Query: 274 LGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGV---DQTHSG 330
LGY V +L+ + +L FA PEH+ DS VL+S G + + G +
Sbjct: 168 LGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDV 227
Query: 331 LPLHHIRRMFMGDSCPYLAGKPKMFFIQN-YVVSEGQL----EDSSLLEVDGPAMKNVEF 385
L I ++F +C L KPK+ +Q G+L +SL + + +N+E
Sbjct: 228 LLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEA 287
Query: 386 KAQKRGLCTVHREADF 401
+ +C +H E DF
Sbjct: 288 DS----VCKIHEEKDF 299
>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
Length = 434
Score = 45.8 bits (107), Expect = 9e-05
Identities = 38/136 (27%), Positives = 61/136 (44%), Gaps = 12/136 (8%)
Query: 274 LGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGV---DQTHSG 330
LGY V +L+ + +L FA PEH+ DS VL+S G + + G +
Sbjct: 226 LGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDV 285
Query: 331 LPLHHIRRMFMGDSCPYLAGKPKMFFIQN-YVVSEGQL----EDSSLLEVDGPAMKNVEF 385
L I ++F +C L KPK+ +Q G+L +SL + + +N+E
Sbjct: 286 LLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEA 345
Query: 386 KAQKRGLCTVHREADF 401
+ +C +H E DF
Sbjct: 346 DS----VCKIHEEKDF 357
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 44.3 bits (103), Expect = 2e-04
Identities = 30/89 (33%), Positives = 43/89 (48%), Gaps = 3/89 (3%)
Query: 273 SLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYG---VDQTHS 329
+LGY V +L+ ++ L FA PEH+ DS V +S G + + G +Q
Sbjct: 102 NLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPD 161
Query: 330 GLPLHHIRRMFMGDSCPYLAGKPKMFFIQ 358
L L+ I M +CP L KPK+ IQ
Sbjct: 162 ILQLNAIFNMLNTKNCPSLKDKPKVIIIQ 190
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 44.3 bits (103), Expect = 2e-04
Identities = 30/89 (33%), Positives = 43/89 (48%), Gaps = 3/89 (3%)
Query: 273 SLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYG---VDQTHS 329
+LGY V +L+ ++ L FA PEH+ DS V +S G + + G +Q
Sbjct: 195 NLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPD 254
Query: 330 GLPLHHIRRMFMGDSCPYLAGKPKMFFIQ 358
L L+ I M +CP L KPK+ IQ
Sbjct: 255 ILQLNAIFNMLNTKNCPSLKDKPKVIIIQ 283
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 44.3 bits (103), Expect = 2e-04
Identities = 30/89 (33%), Positives = 43/89 (48%), Gaps = 3/89 (3%)
Query: 273 SLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYG---VDQTHS 329
+LGY V +L+ ++ L FA PEH+ DS V +S G + + G +Q
Sbjct: 174 NLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPD 233
Query: 330 GLPLHHIRRMFMGDSCPYLAGKPKMFFIQ 358
L L+ I M +CP L KPK+ IQ
Sbjct: 234 ILQLNAIFNMLNTKNCPSLKDKPKVIIIQ 262
>gi|15431332 caspase 1 isoform delta [Homo sapiens]
Length = 263
Score = 44.3 bits (103), Expect = 2e-04
Identities = 30/89 (33%), Positives = 43/89 (48%), Gaps = 3/89 (3%)
Query: 273 SLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYG---VDQTHS 329
+LGY V +L+ ++ L FA PEH+ DS V +S G + + G +Q
Sbjct: 102 NLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPD 161
Query: 330 GLPLHHIRRMFMGDSCPYLAGKPKMFFIQ 358
L L+ I M +CP L KPK+ IQ
Sbjct: 162 ILQLNAIFNMLNTKNCPSLKDKPKVIIIQ 190
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,667,472
Number of Sequences: 37866
Number of extensions: 776222
Number of successful extensions: 2292
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 2178
Number of HSP's gapped (non-prelim): 84
length of query: 480
length of database: 18,247,518
effective HSP length: 106
effective length of query: 374
effective length of database: 14,233,722
effective search space: 5323412028
effective search space used: 5323412028
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.