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Search of human proteins with 104526627
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|104526627 triadin [Homo sapiens]
(729 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|104526627 triadin [Homo sapiens] 1434 0.0
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 170 5e-42
gi|110349719 titin isoform N2-A [Homo sapiens] 109 1e-23
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 105 1e-22
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 105 1e-22
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 103 7e-22
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 102 2e-21
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 101 2e-21
gi|87299628 biorientation of chromosomes in cell division 1-like... 100 5e-21
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 99 2e-20
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 99 2e-20
gi|148746195 trichohyalin [Homo sapiens] 98 2e-20
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 96 9e-20
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 96 2e-19
gi|125656165 THO complex 2 [Homo sapiens] 93 8e-19
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 93 8e-19
gi|58082089 hypothetical protein LOC161394 [Homo sapiens] 91 5e-18
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 89 2e-17
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 89 2e-17
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 86 9e-17
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 85 2e-16
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 84 4e-16
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho... 84 6e-16
gi|150170670 piccolo isoform 2 [Homo sapiens] 83 8e-16
gi|150378539 piccolo isoform 1 [Homo sapiens] 83 8e-16
gi|4557509 cylicin 2 [Homo sapiens] 83 1e-15
gi|221219020 NYD-SP11 protein [Homo sapiens] 82 1e-15
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 82 1e-15
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 82 2e-15
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 81 3e-15
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 1434 bits (3711), Expect = 0.0
Identities = 729/729 (100%), Positives = 729/729 (100%)
Query: 1 MTEITAEGNASTTTTVIDSKNGSVPKSPGKVLKRTVTEDIVTTFSSPAAWLLVIALIITW 60
MTEITAEGNASTTTTVIDSKNGSVPKSPGKVLKRTVTEDIVTTFSSPAAWLLVIALIITW
Sbjct: 1 MTEITAEGNASTTTTVIDSKNGSVPKSPGKVLKRTVTEDIVTTFSSPAAWLLVIALIITW 60
Query: 61 SAVAIVMFDLVDYKNFSASSIAKIGSDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEE 120
SAVAIVMFDLVDYKNFSASSIAKIGSDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEE
Sbjct: 61 SAVAIVMFDLVDYKNFSASSIAKIGSDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEE 120
Query: 121 DDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKP 180
DDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKP
Sbjct: 121 DDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKP 180
Query: 181 EKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEV 240
EKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEV
Sbjct: 181 EKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEV 240
Query: 241 QKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS 300
QKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS
Sbjct: 241 QKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS 300
Query: 301 RPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQ 360
RPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQ
Sbjct: 301 RPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQ 360
Query: 361 GTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDK 420
GTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDK
Sbjct: 361 GTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDK 420
Query: 421 QVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKE 480
QVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKE
Sbjct: 421 QVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKE 480
Query: 481 EKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQI 540
EKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQI
Sbjct: 481 EKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQI 540
Query: 541 HKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPT 600
HKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPT
Sbjct: 541 HKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPT 600
Query: 601 PKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKD 660
PKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKD
Sbjct: 601 PKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKD 660
Query: 661 VEDVPASKKAKEGTEDVSPTKQKSPISFFQCVYLDGYNGYGFQFPFTPADRPGESSGQAN 720
VEDVPASKKAKEGTEDVSPTKQKSPISFFQCVYLDGYNGYGFQFPFTPADRPGESSGQAN
Sbjct: 661 VEDVPASKKAKEGTEDVSPTKQKSPISFFQCVYLDGYNGYGFQFPFTPADRPGESSGQAN 720
Query: 721 SPGQKQQGQ 729
SPGQKQQGQ
Sbjct: 721 SPGQKQQGQ 729
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 170 bits (430), Expect = 5e-42
Identities = 164/604 (27%), Positives = 265/604 (43%), Gaps = 63/604 (10%)
Query: 91 LVRDAMEETTDWIYGFFSLLSDIISSEDEE--DDDGDEDTDKGEIDEPPLRKKEIHKDKT 148
+V + EET + ++ E++E +++G E+ + GE +E ++E
Sbjct: 456 IVEEQTEET--------QVTEEVTEEEEKEAKEEEGKEE-EGGEEEEAEGGEEETKSPPA 506
Query: 149 EKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKA 208
E+ PE++ ++ V KE+ K + + EK E K+ + K +K K K AK +A
Sbjct: 507 EEAASPEKEAKSPV--KEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA 564
Query: 209 KTAEKSEEKTKKEVKGGKQEKVKQTA---AKVKEVQKTPSKPKE--KEDKEKAAVSKHEQ 263
K+ EK E K+ EVK EK K A AK K+P K K KE+ + A +K
Sbjct: 565 KSPEKEEAKSPAEVKS--PEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPV 622
Query: 264 KDQYAFCRYMIDIFVHGDLKPGQSPA-IPPPLPTEQASRPTPASPALEEKEGEKKKAEKK 322
K++ +SPA + P E+A PT EK +K E K
Sbjct: 623 KEE------------------AKSPAEVKSP---EKAKSPTKEEAKSPEKAKSPEKEEAK 661
Query: 323 VTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKK 382
+ K K + K + ++ + E K P KA + K +A + E+ + +K
Sbjct: 662 SPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEK 721
Query: 383 TKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAV 442
K P + E +K + K E AKSP+K S K + K+ AK A ++
Sbjct: 722 AKSPVKEEAKTPEKAKSPVK--EEAKSPEKAKSPEKAKTLDVKSPEAKTP--AKEEARSP 777
Query: 443 PGKKEEKTTKTVEQEIRKEKSGKT----SSILKDKEPIKGKEEKVPASLKEKEPETKKDE 498
K EK V++E++ + K+ + +KE K +E K P +EK E K E
Sbjct: 778 ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837
Query: 499 KMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEA-KPAISEK----VQIHKQDIVKPEKTVS 553
KA +E P P+ + KK+ K E KKEA KP + EK V+ K+ V+ +K +
Sbjct: 838 PPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEA 897
Query: 554 HGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKP-KPTPKGTSEVTESGK 612
K + ++ +E KP +K E ++EP K +P KP K + +
Sbjct: 898 EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDT 957
Query: 613 KKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKE 672
K+ + + E K K + K ++K +++ S KAEK + S D SK ++
Sbjct: 958 KEEKAKKPEEKPKTEAKAKEDDKTLSKEPS-----KPKAEKAEKSSS--TDQKDSKPPEK 1010
Query: 673 GTED 676
TED
Sbjct: 1011 ATED 1014
Score = 151 bits (381), Expect = 2e-36
Identities = 145/557 (26%), Positives = 235/557 (42%), Gaps = 67/557 (12%)
Query: 141 KEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEK----P 196
K + K + E E+ +T+VT + E+ +++ +E+E E++ +E+ E E+ P
Sbjct: 445 KVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSP 504
Query: 197 ETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTA-AKVKEVQKTPSKPKEKEDKEK 255
+ A +K+AK+ K E K+ E K ++E+ K A K E K+P+K + K E
Sbjct: 505 PAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA 564
Query: 256 AAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGE 315
+ K E K P E S SPA EE
Sbjct: 565 KSPEKEEAKS-----------------------------PAEVKSPEKAKSPAKEEA--- 592
Query: 316 KKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDE 375
K AE K + K KE+ K +E ++ + E K P + ++ +A + +
Sbjct: 593 KSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKA 652
Query: 376 KKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGA 435
K + ++ K P + + P + + EK AKSP K + +K E AK A
Sbjct: 653 KSPEKEEAKSPEKAKSPVKAEAKSPEK----AKSPVKAEAKSPEKAKSPVKEEAKSPEKA 708
Query: 436 VSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETK 495
S K K EK V++E + + K+ + K P K K + +L K PE K
Sbjct: 709 KSPVKE-EAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAK 767
Query: 496 ---KDEKMSKAGK--EVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEK 550
K+E S A K E P + + K EK + +K++AK EK K+++ P K
Sbjct: 768 TPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAP--EKEIPKKEEVKSPVK 825
Query: 551 TVSHGKPEE-------KVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIK--------TD 595
KP+E K ++ KA KT + K +KK E ++E P K +
Sbjct: 826 --EEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883
Query: 596 KPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPA 655
KPK + + KKK EKE+ K ++K + K T + + KA++P+
Sbjct: 884 KPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDD-AKAKEPS 942
Query: 656 RVSKDVEDVPASKKAKE 672
+ ++ E P K KE
Sbjct: 943 KPAEKKEAAPEKKDTKE 959
Score = 139 bits (349), Expect = 1e-32
Identities = 138/456 (30%), Positives = 198/456 (43%), Gaps = 77/456 (16%)
Query: 141 KEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIE----KKEKP 196
KE K E + + K TK K EK K +E+ K +KA K E +K K
Sbjct: 623 KEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKS 682
Query: 197 ETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVK---QTAAKVKEVQKTPSKPKE--KE 251
K AK +KAK+ K E K+ ++ K +E+ K + + VKE KTP K K KE
Sbjct: 683 PVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKE 742
Query: 252 DKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASR----PTPASP 307
+ + +K +K + +D+ +SP P E S P A
Sbjct: 743 EAKSPEKAKSPEKAK------TLDV---------KSPEAKTPAKEEARSPADKFPEKAKS 787
Query: 308 ALEEKEGEKKKAEKKVTSETKKKEKEDIKKKS------EKETAIDVEKKEPGKASETKQG 361
++E+ +KA+ + + K EKE KK+ E+E +V+ KEP K +E ++
Sbjct: 788 PVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA 847
Query: 362 TVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQ 421
A K E+K+DSKK + P + E PK K +EKKE VE P + +
Sbjct: 848 -------PATPKTEEKKDSKKEEAPKK-EAPKPKVEEKKEPAVEK----------PKESK 889
Query: 422 VKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEE 481
V+AK E A++ KK VP ++E K +E K K KT K+ + K KE
Sbjct: 890 VEAKKEEAED-------KKKVPTPEKEAPAKVEVKEDAKPKE-KTEVAKKEPDDAKAKEP 941
Query: 482 KVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIH 541
PA KE PE KKD K KA +KPE + K EAK +K
Sbjct: 942 SKPAEKKEAAPE-KKDTKEEKA----------------KKPEEKPKTEAKAKEDDKTLSK 984
Query: 542 KQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPK 577
+ K EK ++K K + T +K AK K
Sbjct: 985 EPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 124 bits (311), Expect = 3e-28
Identities = 133/535 (24%), Positives = 214/535 (40%), Gaps = 62/535 (11%)
Query: 157 KIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEE 216
KI + TH K K +EK++ EK EK+ E+ ++ + + +E+K+AK E EE
Sbjct: 428 KIPSVSTHI-KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEE 486
Query: 217 K--TKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMI 274
+ ++E +GG++E A + +K P ++E K A E+++ +
Sbjct: 487 EGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS------ 540
Query: 275 DIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKED 334
P E S SPA EE K E K + + K +
Sbjct: 541 --------------------PAEVKSPEKAKSPAKEEA---KSPPEAKSPEKEEAKSPAE 577
Query: 335 IKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKG 394
+K + ++ E K P +A ++ + +A + + K ++ K PAEV+ P+
Sbjct: 578 VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEK 637
Query: 395 KKQEKKE--KHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTK 452
K KE K E AKSP+KE + +K AK A S KA K EK
Sbjct: 638 AKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKA-EAKSPEKAKS 696
Query: 453 TVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPP 512
V++E + + K+ + K P K K P + K PE K +A K K P
Sbjct: 697 PVKEEAKSPEKAKSPVKEEAKSPEKAKS---PVKEEAKTPEKAKSPVKEEAKSPEKAKSP 753
Query: 513 QLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEK 572
+ + K + P+ K AK PEK S K E K ++ K+ +++
Sbjct: 754 E-KAKTLDVKSPEAKTPAKEEARSPADKF------PEKAKSPVKEEVKSPEKAKS-PLKE 805
Query: 573 TAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLR 632
AK + + E + P + +KP+ K E +K +EKA
Sbjct: 806 DAKAPEKEIPKKEEVKSPVKEEEKPQEV------------KVKEPPKKAEEEKAPATPKT 853
Query: 633 EEKVSTRKESLQLHNVTK----AEKPARVSKDVEDVPASKKAKEGTEDVSPTKQK 683
EEK ++KE K +K V K E +KK + + PT +K
Sbjct: 854 EEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEK 908
Score = 106 bits (264), Expect = 9e-23
Identities = 133/554 (24%), Positives = 229/554 (41%), Gaps = 63/554 (11%)
Query: 183 KATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQK 242
++ +E E + + + +T E + K+ + S E+ + E++ Q + ++++
Sbjct: 312 RSAQEEITEYRRQLQARTT--ELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDA 369
Query: 243 TPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAI---PPPLPTEQA 299
K E AA + Q I+I + L G+ I P P +
Sbjct: 370 ELRNTKW----EMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEG 425
Query: 300 SRPTPA-SPALEEKEGEKKKAEKKVTSETKKKEK--------EDIKKKSEKETAIDVEKK 350
P+ S ++ K EK K +K ET E+ E++ ++ EKE + K+
Sbjct: 426 LPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKE 485
Query: 351 EPG--------------------KASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVE 390
E G AS K+ + +A + + K + ++ K PAEV+
Sbjct: 486 EEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVK 545
Query: 391 QPKGKKQEKKEKHVEP--AKSPKKEHS-----VPSDKQVKAKT-ERAKEEIGAVSIKKA- 441
P+ K KE+ P AKSP+KE + V S ++ K+ E AK A S +KA
Sbjct: 546 SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAK 605
Query: 442 VPGKKEEKTTKTVEQEIRKE--KSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEK 499
P K+E K+ + +++E + S K K P K +E K P K E E K +
Sbjct: 606 SPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTK-EEAKSPEKAKSPEKEEAKSPE 664
Query: 500 MSKAGKEVKPKPPQ-------LQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTV 552
+K+ + + K P+ + K EK + +K+EAK K + K++ PEK
Sbjct: 665 KAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPV-KEEAKSPEKAK 723
Query: 553 SHGKPEEKVLKQVKAVTIEKTAKPKPTK---KAEHREREPPSIKTDKPKPTPKGTSEVTE 609
S K E K ++ K+ E+ P+ K KA+ + + P KT + + E
Sbjct: 724 SPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPE 783
Query: 610 SGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKK 669
K + E +S EKA L+E+ + KE + V K ++V+ KK
Sbjct: 784 KAKSPVK-EEVKSPEKA-KSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKK 841
Query: 670 AKEGTEDVSPTKQK 683
A+E +P ++
Sbjct: 842 AEEEKAPATPKTEE 855
Score = 94.0 bits (232), Expect = 4e-19
Identities = 106/389 (27%), Positives = 163/389 (41%), Gaps = 24/389 (6%)
Query: 313 EGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAK 372
EG K + K +EK + +KSEKET I E+ E + +E V + AK
Sbjct: 424 EGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEE----VTEEEEKEAK 479
Query: 373 KDEKKEDSKKTKKPAE--VEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAK 430
++E KE+ ++ AE E+ K E+ + AKSP KE + + + E AK
Sbjct: 480 EEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAK 539
Query: 431 EEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKS---GKTSSILKDKEPIKGKEEKVPASL 487
S +KA KEE + + KE++ + S K K P K +E K PA
Sbjct: 540 SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAK-EEAKSPAEA 598
Query: 488 K--EKEPETKKDEKMSKAG-----KEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQI 540
K EK K+E S A KE P ++ K EK + K+EAK K
Sbjct: 599 KSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEV--KSPEKAKSPTKEEAKSPEKAK-SP 655
Query: 541 HKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPT 600
K++ PEK S K E K ++ K+ + P+ K E + P K
Sbjct: 656 EKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 715
Query: 601 PKGTSEVTESGKKKTEISEK-ESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPAR--V 657
K + K++ + EK +S K + K + K + ++L + + +A+ PA+
Sbjct: 716 AKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKS-PEAKTPAKEEA 774
Query: 658 SKDVEDVPASKKAKEGTEDVSPTKQKSPI 686
+ P K+ E SP K KSP+
Sbjct: 775 RSPADKFPEKAKSPVKEEVKSPEKAKSPL 803
Score = 64.7 bits (156), Expect = 3e-10
Identities = 52/146 (35%), Positives = 74/146 (50%), Gaps = 11/146 (7%)
Query: 126 EDTDKGEIDEPPLRKKEIHKDKTEKQEK---PERKIQTKVTHKEKEKGKEK--VREKEKP 180
E+ + +++P K E K++ E ++K PE++ KV KE K KEK V +KE
Sbjct: 875 EEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPD 934
Query: 181 EKKATHKEK-IEKKEKPETKTLAKEQKKAKTAE--KSEEKTKKEVKGGKQEKVKQTAAKV 237
+ KA K EKKE K KE+K K E K+E K K++ K +E K A K
Sbjct: 935 DAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKA 994
Query: 238 KEVQKT---PSKPKEKEDKEKAAVSK 260
++ T SKP EK ++KAA K
Sbjct: 995 EKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 32.3 bits (72), Expect = 1.6
Identities = 29/97 (29%), Positives = 42/97 (43%), Gaps = 22/97 (22%)
Query: 119 EEDDDGDEDTDKGEIDEP--PLRKKEIHKDKT----EKQEKPERKIQTKVTHKE------ 166
E+ + ++ D + EP P KKE +K EK +KPE K +T+ KE
Sbjct: 924 EKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLS 983
Query: 167 KEKGKEKVREKEK----------PEKKATHKEKIEKK 193
KE K K + EK P +KAT + + K
Sbjct: 984 KEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 109 bits (272), Expect = 1e-23
Identities = 152/646 (23%), Positives = 262/646 (40%), Gaps = 98/646 (15%)
Query: 107 FSLLSDIISSEDEEDDDGDEDTDKGEIDE-PPLRKKEIHKDKTEKQEKPERKIQTKVTHK 165
++L + +S + EE+ + E+ D E +E P + + +++ E++ + + + +T
Sbjct: 9730 YTLEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEP 9789
Query: 166 EKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKS---------EE 216
EK + V E+ P K K+ KK PE K KK K EE
Sbjct: 9790 EKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEE 9849
Query: 217 KTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHE-------------- 262
K + + ++E+V + AAKV P KPK +EK V + E
Sbjct: 9850 KIRISITKREKEQVTEPAAKV------PMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKEL 9903
Query: 263 QKDQYAFCRYMI-----------DIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEE 311
+ ++ AF ++ + ++H + + + P +P + P P EE
Sbjct: 9904 EPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPE--VPRKPVPEE 9961
Query: 312 KE----GEKKKAEKKVTSETKKKEKEDI-----KKKSEKETAIDVEKKEPGKASETKQGT 362
K+ +KK+A E KK +E + KK+ + K+P +
Sbjct: 9962 KKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPV 10021
Query: 363 VKIAAQAAAKKDEKKEDSKKTKK-----PAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVP 417
K AK E + KK P +VE P K E +K + K P P
Sbjct: 10022 PKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKP-----TP 10076
Query: 418 SDKQVKAKTERAKEEIGAVSIKKAVPGKKE---------EKTTKTVEQEIRKEKS---GK 465
K+V+A + ++ V + A+P ++E E+ E+E+ E+ +
Sbjct: 10077 VPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPE 10136
Query: 466 TSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQ 525
+L ++E I +EE+VP +E PE ++ + EVKPK P P P+
Sbjct: 10137 EEEVLPEEEEIPPEEEEVPPE-EEYVPEEEEFVPEEEVLPEVKPKVP------VPAPVPE 10189
Query: 526 IKKEAKPAISEKVQIHKQDIVKPEKTVS-HGKPEEKVL---KQVKAVTIEKTAKPKPTKK 581
IKK+ +KV I K++ P K K EEK + K+ + + +E T +P+
Sbjct: 10190 IKKK---VTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPI 10246
Query: 582 AEHR-EREPPSIKTDKPKPTPKGTSEVTES-GKKKTEISEKESKEKADM-KHLREEKVST 638
+E EPPSI+ + P+ + ++ + T + +K A + K + EEKV
Sbjct: 10247 SEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPV 10306
Query: 639 RKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKS 684
+ K PA+V + + VP K E V P K ++
Sbjct: 10307 PVQK-------KEAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKGRT 10345
Score = 98.2 bits (243), Expect = 2e-20
Identities = 154/633 (24%), Positives = 264/633 (41%), Gaps = 100/633 (15%)
Query: 117 EDEEDDDGDEDTDKGEID--EPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKG---- 170
E +E + +E D+GE + E ++ I K +E ERK+ KV K+
Sbjct: 9122 EGQEYYEREEGYDEGEEEWEEAYQEREVIQVQKEVYEESHERKVPAKVPEKKAPPPPKVI 9181
Query: 171 KEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSE--------EKTKKEV 222
K+ V EK + + +EK++ + PE QK ++T + E TKK V
Sbjct: 9182 KKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMV 9241
Query: 223 KGGKQEKVKQTAAKVKEVQKT-PSKPKE--KEDKEKAAVSKHEQKDQYAFCRYMIDIFVH 279
+EK+ + +EV T P KE E+K A+SK +
Sbjct: 9242 I--SEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKV---------PE 9290
Query: 280 GDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKK----AEKKVTSETKKKEKEDI 335
KP P P+P ++ P P P + +K ++K KK + K +
Sbjct: 9291 LPEKPAPEEVAPVPIP-KKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPK 9349
Query: 336 KKKSEKETAIDVEKKE---PGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQP 392
K E++ + V KK+ P K E ++G V +K +++ PA E P
Sbjct: 9350 KPVPEEKIPVPVAKKKEAPPAKVPEVQKGVV------TEEKITIVTQREESPPPAVPEIP 9403
Query: 393 KGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKA--KTERAKEEIGA-VSIKKAVPGKKEEK 449
K K E+++ P+KE VP +V A K +E++ V + K P + E
Sbjct: 9404 KKKVPEERK------PVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEV 9457
Query: 450 TTKTVEQEIR-------------------------------KEKSGKTSSILKDKEPIKG 478
+ KTV +E R +E+ G + S+ +++E +
Sbjct: 9458 SKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEE 9517
Query: 479 KEEKVPASLKEKEPET-KKDEKMSKAGKEVKPKPPQLQGKKEEK--PEPQIKKEAKPAIS 535
+E +V +EPE +EK+ K V+ +P ++ ++E+K +P+I + +
Sbjct: 9518 EEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPP 9577
Query: 536 EKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTD 595
KV + IV PEK V P+++ + K E+ KP P KK P IK +
Sbjct: 9578 AKVPEAPKKIV-PEKKVPAPVPKKEKVPPPKVP--EEPKKPVPEKKV-----PPKVIKME 9629
Query: 596 KPKP--TPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEK 653
+P P + ++T+ K +++KE+ KA + + V K L+L + E
Sbjct: 9630 EPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEK-VLKLKPKREEEP 9688
Query: 654 PARVSKDVEDVPASKKAKEGTEDVSPTKQKSPI 686
PA+V++ + V K+ K E +P ++ PI
Sbjct: 9689 PAKVTEFRKRV--VKEEKVSIE--APKREPQPI 9717
Score = 97.1 bits (240), Expect = 5e-20
Identities = 142/622 (22%), Positives = 245/622 (39%), Gaps = 98/622 (15%)
Query: 132 EIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEK-------EKGKEKVREKEKPEK-- 182
+I+EPP K + K+ PE+K+ V KEK E+ K+ V EK+ P K
Sbjct: 9571 KIEEPPPAKVP----EAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVI 9626
Query: 183 ---------------KATHKEK----IEKKEKP-------ETKTLAKEQKKAKTAEKSEE 216
+ T +EK + KKE P E K E+K K K EE
Sbjct: 9627 KMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREE 9686
Query: 217 KTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKE---KEDKEKA------AVSKHEQKDQY 267
+ +V ++ VK+ ++ ++ P KE E+KE+A AVS +++
Sbjct: 9687 EPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQREEEYE 9746
Query: 268 AFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSET 327
+ Y F + PTE+ + EE+E E+ + ++ +E
Sbjct: 9747 EYEEYDYKEFEEYE-------------PTEEYDQ----YEEYEEREYERYEEHEEYITEP 9789
Query: 328 KKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPA 387
+K I K E + + K P A K+ + K K K ++P
Sbjct: 9790 EK----PIPVKPVPEEPVPTKPKAP-PAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPK 9844
Query: 388 EVEQPKGK----KQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVP 443
+V + K + K+EK++ AK P K V ++++V + + + K +
Sbjct: 9845 KVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELE 9904
Query: 444 GKK---EEKTTKTVEQ---EIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKD 497
++ EE+ VE+ E +E + + ++E + KVP ++ PE KK
Sbjct: 9905 PEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKP 9964
Query: 498 EKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKP 557
+ K + K P++ K EEK I K+ KP ++ ++ K+ + PE+ V P
Sbjct: 9965 VPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPV--PEEKVPVPVP 10022
Query: 558 EEKVLKQVKAVTIEKTAKPKPTKK----AEHREREPPS----------IKTDKPKPTPKG 603
++ K + K KP P KK A + PP+ + KP P PK
Sbjct: 10023 KKVEAPPAKVPEVPK--KPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKK 10080
Query: 604 TSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVED 663
KK E + + L EE++ +E L E+ + ++ E
Sbjct: 10081 VEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEV 10140
Query: 664 VPASKKAKEGTEDVSPTKQKSP 685
+P ++ E+V P ++ P
Sbjct: 10141 LPEEEEIPPEEEEVPPEEEYVP 10162
Score = 91.3 bits (225), Expect = 3e-18
Identities = 132/550 (24%), Positives = 216/550 (39%), Gaps = 97/550 (17%)
Query: 132 EIDEPPLRKKEIHKDKTEKQEK---PERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKE 188
++ PP +K E+ K + K PE+K+ + K + E E E+ + E
Sbjct: 10621 KVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPAE 10680
Query: 189 KIE--------------KKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTA 234
+E KK PE K A KK + + KEV ++KV
Sbjct: 10681 VVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVV--PEKKVPLVV 10738
Query: 235 AKVKEVQ--KTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPP 292
K E K P PKE ++K AV K KP PA P
Sbjct: 10739 PKKPEAPPAKVPEVPKEVVPEKKVAVPK----------------------KPEVPPAKVP 10776
Query: 293 PLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEP 352
+P + PA P E E + + E E+I E+E A + EK P
Sbjct: 10777 EVPKKPVLEEKPAVPVPERAESPPPEVYE---------EPEEIAP--EEEIAPEEEKPVP 10825
Query: 353 GKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKK 412
E + + A ++ +K KK + E P K+ E ++ +P P+
Sbjct: 10826 VAEEEEPE----VPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRP 10881
Query: 413 EHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKD 472
P+ + E KE+I + KA+P KK + + E+ +
Sbjct: 10882 PPPPPAPPK-----EDVKEKIFQL---KAIPKKKVPEKPQVPEKV--------------E 10919
Query: 473 KEPIK--GKEEKVPASLKEKEPETKKDEKM-SKAGKEVKPKPPQLQGKKEEK-PEPQIKK 528
P+K G E+KV L E++PE K++ + S K + + P+++ KK EK +P + +
Sbjct: 10920 LTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPE 10979
Query: 529 EAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHRERE 588
P E+V++ + K E+ + PE + ++K +PKP +AE + +
Sbjct: 10980 PPPPKPVEEVEV--PTVTKRERKI----PEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIK 11033
Query: 589 PPSIKTDKPKPTPKGTSEVTESGKKKTEI---SEKESKEKADMKHLREEKVS-TRKESLQ 644
PP + +P+PTP KK E E+ +K K +K + ++ S E +
Sbjct: 11034 PPPV---EPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAERRK 11090
Query: 645 LHNVTKAEKP 654
L + EKP
Sbjct: 11091 LRPGSGGEKP 11100
Score = 90.5 bits (223), Expect = 5e-18
Identities = 146/611 (23%), Positives = 245/611 (40%), Gaps = 97/611 (15%)
Query: 112 DIISSEDEEDDDGDEDTDKGEIDEP--PLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEK 169
++I + E ++ E ++ E P K I K EK EK R+++ + K
Sbjct: 9148 EVIQVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVP 9207
Query: 170 GKEKVREKEKPEKKATHKEKIEKKEKP-ETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQE 228
K +KP + +E IE K TK + ++K A +EE+ V ++E
Sbjct: 9208 EVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKE 9267
Query: 229 KVKQT------AAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDL 282
V + + +V+ K P P++ +E A V ++ + A + +
Sbjct: 9268 IVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEE 9327
Query: 283 K-----PGQSPAIPPPLPTEQASRPTPAS----PALEEKEGEKKKA---------EKKVT 324
K P + PA PP +P E +P P P ++KE K E+K+T
Sbjct: 9328 KKPVPVPKKEPAAPPKVP-EVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKIT 9386
Query: 325 SETKKKEKE-----DIKKKSEKETAIDVEKKE-----PGKASETKQGTV---KIAAQAAA 371
T+++E +I KK E V +KE P K + V K+A
Sbjct: 9387 IVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPV 9446
Query: 372 KKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQ---------- 421
K ++ +KK V + K E+K P + H V ++++
Sbjct: 9447 AKKAPPPRAEVSKKT--VVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGV 9504
Query: 422 ---VKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKG 478
V + ER +EE V+ + V + EE + I K + + + + +E
Sbjct: 9505 SISVYREEEREEEEEAEVT-EYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIV 9563
Query: 479 KEEKVPASLKEKEPETKKDEKMSKAGKEVKP--KPPQLQGKKEEKPEPQIKKEAKPAISE 536
+ K+PA ++E P K+ +A K++ P K P KKE+ P P++ +E K + E
Sbjct: 9564 LKPKIPAKIEEPPP-----AKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPE 9618
Query: 537 K---------------------VQIHKQDIVKPEKTVSHGKPEEKVLKQVK-AVTIEKTA 574
K +QI +++ V T P+ +V ++ K AV EK
Sbjct: 9619 KKVPPKVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVL 9678
Query: 575 KPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKK----TEISEKESKEKADMKH 630
K KP RE EPP+ T+ K K E+ K++ E++ E KE+A
Sbjct: 9679 KLKP-----KREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERA--YT 9731
Query: 631 LREEKVSTRKE 641
L EE VS ++E
Sbjct: 9732 LEEEAVSVQRE 9742
Score = 89.7 bits (221), Expect = 8e-18
Identities = 137/645 (21%), Positives = 254/645 (39%), Gaps = 122/645 (18%)
Query: 126 EDTDKGEIDEPPLR---KKEIHKDKTEKQEKPERKIQT--KVTHKEKEKGKEKVREKEKP 180
E K + E P R ++++ K K +++E+P K+ K KE++ E + + +P
Sbjct: 9657 EAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQP 9716
Query: 181 EKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEV 240
K+ T E EK TL +E + E+ EE + + K ++ E
Sbjct: 9717 IKEVTIME-----EKERAYTLEEEAVSVQREEEYEEYEEYDYKEFEE----------YEP 9761
Query: 241 QKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIP-----PP-- 293
+ + +E E++E +HE+ Y+ + +KP +P PP
Sbjct: 9762 TEEYDQYEEYEEREYERYEEHEE--------YITEPEKPIPVKPVPEEPVPTKPKAPPAK 9813
Query: 294 -----LPTEQASRPTPAS---PALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEK---- 341
+P E+ P P P + E KK E+K+ K+EKE + + + K
Sbjct: 9814 VLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMK 9873
Query: 342 ------ETAIDVEKK---------------EPGKASETKQGTVKIAAQAAAKKDEKKEDS 380
E + V +K EP + + ++ + +++E +
Sbjct: 9874 PKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEE 9933
Query: 381 KKTKKPAEV---------EQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKE 431
++ EV E P+ E+K +P PKK+ + P+ K K
Sbjct: 9934 EEFITEEEVVPVIPVKVPEVPRKPVPEEK----KPVPVPKKKEAPPAKVPEVPKKPEEKV 9989
Query: 432 EIGAVSIKKAVPGKKEEKTTKTVEQE-----IRKEKSGKTSSILK-DKEPIKGKEEKVPA 485
+ +K P K E K V +E + K+ + + + K+P+ K+ VPA
Sbjct: 9990 PVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPA 10049
Query: 486 SLKEKEPETK----------KDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAIS 535
K + P K +++K + K+V+ PP++ K+E P P + + +
Sbjct: 10050 PKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLF 10109
Query: 536 EKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPP----- 590
E+ + +++++ E+ V EE+VL + + V E+ P ++ E P
Sbjct: 10110 EEEIVPEEEVLPEEEEVL--PEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEF 10167
Query: 591 ----------SIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADM----KHLREEKV 636
K P P P+ +VTE KK I +KE A + K + E+++
Sbjct: 10168 VPEEEVLPEVKPKVPVPAPVPEIKKKVTE---KKVVIPKKEEAPPAKVPEVPKKVEEKRI 10224
Query: 637 STRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTK 681
KE ++ V E+P E++P + E E+V+P +
Sbjct: 10225 ILPKEE-EVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPR 10268
Score = 87.0 bits (214), Expect = 5e-17
Identities = 136/554 (24%), Positives = 224/554 (40%), Gaps = 89/554 (16%)
Query: 146 DKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEK---IEKKEKP------ 196
D + K E E KI T KE +K KE V EK K+A HKEK IE E+P
Sbjct: 9029 DVSSKAE--EVKIMTITRKKEVQKEKEAVYEK----KQAVHKEKRVFIESFEEPYDELEV 9082
Query: 197 ETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKA 256
E T EQ + ++ E+ K E K E+ ++ + +E + E E++ +
Sbjct: 9083 EPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEE 9142
Query: 257 AVSKHE----QKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEK 312
A + E QK+ Y + +P +P ++A P
Sbjct: 9143 AYQEREVIQVQKEVY---------------EESHERKVPAKVPEKKAPPPPKVI------ 9181
Query: 313 EGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQG-TVKIAAQAAA 371
KK +K+ +++ E+E ++ E + + ++P + ++ VK+ A
Sbjct: 9182 ---KKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTK 9238
Query: 372 K---KDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTER 428
K +EK + T++ V P+ +K+ E+ + A S + E P K + +
Sbjct: 9239 KMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVE---PPPKVPELPEKP 9295
Query: 429 AKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLK 488
A EE+ V I P K E K E K+P+ EEK P +
Sbjct: 9296 APEEVAPVPI----PKKVEPPAPKVPE---------------VPKKPV--PEEKKPVPVP 9334
Query: 489 EKEPETKKDEKMSKAGKEVKP--KPPQLQGKKEEKPEPQIKKEAKPAIS-EKVQIHKQDI 545
+KEP K+ + K+ P K P KK+E P ++ + K ++ EK+ I Q
Sbjct: 9335 KKEPAA--PPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQRE 9392
Query: 546 VKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTS 605
P V P++KV ++ K V ++ P P K ++ P K P P K
Sbjct: 9393 ESPPPAVPE-IPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAP 9451
Query: 606 EVTESGKKKTEISEKESKEKADMKHLREEKVS---TRKESLQLHNVTKAEKPARVSKDVE 662
KKT + EK + + EEK+S ++ + H V+ AE+ S++ E
Sbjct: 9452 PPRAEVSKKTVVEEK--------RFVAEEKLSFAVPQRVEVTRHEVS-AEEEWSYSEEEE 9502
Query: 663 DVPASKKAKEGTED 676
V S +E E+
Sbjct: 9503 GVSISVYREEEREE 9516
Score = 79.0 bits (193), Expect = 1e-14
Identities = 143/656 (21%), Positives = 253/656 (38%), Gaps = 116/656 (17%)
Query: 118 DEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKV--- 174
+EE+ +E+ E + P ++ + +++ + KP+ + V +K+ ++KV
Sbjct: 10143 EEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIP 10202
Query: 175 -REKEKPEKKATHKEKIEKK----------------EKPETKTLAKEQ--KKAKTAEKSE 215
+E+ P K +K+E+K E+PE + +++E+ ++ + E+ E
Sbjct: 10203 KKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVE 10262
Query: 216 EKTKKEVKGGKQEKVKQTAAKV-KEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMI 274
E V ++ V + V K+V+ P+K +K +EK V ++
Sbjct: 10263 EVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQKK----------- 10311
Query: 275 DIFVHGDLKPGQSPAIPPPLPTE-------QASRPTPASPALEEKEGEKKKAEKKVTSET 327
+ P + P +P +P + +A P LEEK + E V
Sbjct: 10312 ------EAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERL 10365
Query: 328 KKKEKE-DIKKKSEKETAIDVEKK-EPGKASETKQGTV----KIAAQAAAKKDEKKEDSK 381
+ + E ++++ E+E +VE+ E G+ E ++ ++ + +K + +
Sbjct: 10366 ELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVF 10425
Query: 382 KTKKPAEVEQPKG--KKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIK 439
+ ++ E+PK K E EK + P K P K V K+ AK ++I V K
Sbjct: 10426 EAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTK---VVPRKEPPAKVPEVPKKI-VVEEK 10481
Query: 440 KAVPGKKEEKTTKTVE----QEIRKEKSGKTSSILKD-----------KEPIKGKEEKVP 484
VP + TK E +E+ EK K KE + K+ VP
Sbjct: 10482 VRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVP 10541
Query: 485 ASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEK----VQI 540
K + P TK E A E K P+ K E P P++ + K + EK
Sbjct: 10542 PPKKPEVPPTKVPEVPKAAVPE--KKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPP 10599
Query: 541 HKQDI-----------VKPEKTVSHGKPEEKVLKQVKAVTIEKTA----------KPKPT 579
K ++ V PEK V P++ + K + K A PKP
Sbjct: 10600 KKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPE 10659
Query: 580 KKAEHREREPPSIKTDKP------KPTPKGTSEVTESGKKKTE-------ISEKESKEKA 626
EP + ++P +P P +VT KK +++K
Sbjct: 10660 SPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPV 10719
Query: 627 DMKHLREEKVSTRKESLQLHNVTKAEKPARVSK-DVEDVPASKKAKEGTEDVSPTK 681
+ + +E V +K L + +A PA+V + E VP K A +V P K
Sbjct: 10720 KVPEVPKEVVPEKKVPLVVPKKPEA-PPAKVPEVPKEVVPEKKVAVPKKPEVPPAK 10774
Score = 77.4 bits (189), Expect = 4e-14
Identities = 133/617 (21%), Positives = 230/617 (37%), Gaps = 85/617 (13%)
Query: 132 EIDEPPLRKKEIHKDKTEKQEKP---ERKIQT---KVTHKEKEKGKEKVREKEKPEKKAT 185
+++ PP + E+ K +++ P +K++ KV K+ E+ + P+K
Sbjct: 10024 KVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEA 10083
Query: 186 HKEKIEKKEKPETKTLAKEQKKAKTAEKS---EEKT---KKEVKGGKQEKVKQTAAKVKE 239
K+ KK +P +A Q++ E+ EE+ ++EV ++E + + + E
Sbjct: 10084 PPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPE 10143
Query: 240 VQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFV-HGDLKPGQSPAIPPPLPTEQ 298
++ P + +E +E+ + E FV ++ P P +P P P +
Sbjct: 10144 EEEIPPEEEEVPPEEEYVPEEEE--------------FVPEEEVLPEVKPKVPVPAPVPE 10189
Query: 299 ASRPTPASPALEEKEGE----------KKKAEKKV----------TSETKKKEKEDIKKK 338
+ + K+ E KK EK++ T++ E+E I ++
Sbjct: 10190 IKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEE 10249
Query: 339 S---EKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAE-VEQPKG 394
E + +VE+ P + E + V A KK E K P E V P
Sbjct: 10250 EIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQ 10309
Query: 395 KKQEKKEKHVE-PAKSPKKEHSVPSDKQVK-AKTERAKEEIGAVSIKKAVPGKK------ 446
KK+ K E P K P+K+ VP + V AK EE +V+ ++ V K+
Sbjct: 10310 KKEAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEV 10369
Query: 447 ---------EEKTTKTVEQEIRKEKSGKTSSILK------DKEPIKGKEEKVPASLKEKE 491
EE+ VE+ + + + +K ++E K +V + +E
Sbjct: 10370 VEAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEE 10429
Query: 492 PETKKDEKMSKAGKEVKPK------PPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDI 545
E + K G E+ K PP ++E P + K + EKV++ ++
Sbjct: 10430 VEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPR 10489
Query: 546 VKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTS 605
V P K P+E V ++ V K + P K E + P K P P
Sbjct: 10490 VPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVP 10549
Query: 606 EVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVP 665
K + EK+ E K E V + + PA K E P
Sbjct: 10550 PTKVPEVPKAAVPEKKVPEAIPPK---PESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTP 10606
Query: 666 ASKKAKEGTEDVSPTKQ 682
K E ++V P K+
Sbjct: 10607 V--KVPEAPKEVVPEKK 10621
Score = 70.5 bits (171), Expect = 5e-12
Identities = 94/430 (21%), Positives = 171/430 (39%), Gaps = 27/430 (6%)
Query: 281 DLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSE 340
++ P +P IP LPT + +P P + +K KK A+K V + +E+I KK
Sbjct: 8956 EIPPVVAPPIPLLLPTPEEKKPPPKRIEVTKK-AVKKDAKKVVAKPKEMTPREEIVKKPP 9014
Query: 341 KETAIDVEKKEP------GKASETKQGTVKIAAQAAAKKD---EKKEDSKKTKKPAEVEQ 391
T + + K P KA E K T+ + +K+ EKK+ K K+
Sbjct: 9015 PPTTL-IPAKAPEIIDVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESF 9073
Query: 392 PKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTT 451
+ + + E + EP + P E +++K + ++ E ++ + E+
Sbjct: 9074 EEPYDELEVEPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGY 9133
Query: 452 KTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKE----PETKKD---EKMSKAG 504
E+E + + ++ + + E KVPA + EK+ P+ K EK+ K
Sbjct: 9134 DEGEEEWEEAYQEREVIQVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTS 9193
Query: 505 KEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKV------QIH-KQDIVKPEKTVSHGKP 557
+ ++ + Q+ E + +K ++ + E+V +H K+ ++ EK
Sbjct: 9194 RRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHT 9253
Query: 558 EEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEI 617
EE+V V V E + K R PP + KP P+ + V K +
Sbjct: 9254 EEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPA 9313
Query: 618 SEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDV 677
+ K + ++ +KE V + K V ++ VP +KK KE
Sbjct: 9314 PKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKP-VPEEKIPVPVAKK-KEAPPAK 9371
Query: 678 SPTKQKSPIS 687
P QK ++
Sbjct: 9372 VPEVQKGVVT 9381
Score = 54.3 bits (129), Expect = 4e-07
Identities = 130/624 (20%), Positives = 223/624 (35%), Gaps = 90/624 (14%)
Query: 114 ISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEK 173
I+ E+E + ++ E +EP + + ++ K+ PE+K+ K E
Sbjct: 10810 IAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEP--KKIIPEKKVPVI-------KKPEA 10860
Query: 174 VREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAE-KSEEKTKKEVKGGKQEKVKQ 232
KE +K K K++ + P KE K K + K+ K K K EKV+
Sbjct: 10861 PPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVEL 10920
Query: 233 TAAKVKEVQKTPSK--PKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAI 290
T KV +K K P+ K + ++ V K + + ++ +K P
Sbjct: 10921 TPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEP 10980
Query: 291 PPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKE--------DIKKKSEKE 342
PPP P E+ PT K E+K+ TK E + + K K E E
Sbjct: 10981 PPPKPVEEVEVPTVT------------KRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAE 11028
Query: 343 T-AIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSK----------KTKKPAEVEQ 391
I EP TV + + A K K+E +K KT P E E+
Sbjct: 11029 VKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAER 11088
Query: 392 PKGKKQEKKEKHVEPAKSPKKEHSVPSD--KQVKAKTERAKEEIGAVSIKKAVPGKKEEK 449
K + EK + A + +VP K++K E +G+ +I + +
Sbjct: 11089 RKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSPSTAI 11148
Query: 450 TTKTVE-QEIRKEKSGKTSSILKDKE------------------PIKGKEEKVPASLKEK 490
TT + IR+ + + KD++ + KE+ A L +
Sbjct: 11149 TTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVE 11208
Query: 491 EPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQI---------- 540
E + + + + VK +P L + ++ + +K+ K + + +I
Sbjct: 11209 ELPVRFVKTLEEEVTVVKGQPLYLSCELNKERDVVWRKDGKIVVEKPGRIVPGVIGLMRA 11268
Query: 541 ------HKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKT 594
D TV + E VK V + + KP + + +
Sbjct: 11269 LTINDADDTDAGTYTVTVENANNLE-CSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFAC 11327
Query: 595 DKPKPTP-----KGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQ----L 645
D K TP KG E+ KTEI + +K+ E ++ ++
Sbjct: 11328 DIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYP 11387
Query: 646 HNVTKAEKPARVSKDVEDVPASKK 669
+T E+ + K +EDV +K
Sbjct: 11388 AKLTLGEREVELLKPIEDVTIYEK 11411
Score = 50.8 bits (120), Expect = 4e-06
Identities = 80/373 (21%), Positives = 156/373 (41%), Gaps = 49/373 (13%)
Query: 329 KKEKEDIKKKSEKET---AIDVEK-KEP--GKASETKQGTVKIAAQAAAKKDEKKEDSKK 382
K+ K+D K + T A+D+ + +EP +T Q T A +++ +++++K
Sbjct: 414 KEVKQDADKSAAVATVVAAVDMARVREPVISAVEQTAQRTTTTAVHIQPAQEQVRKEAEK 473
Query: 383 TK-KPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKA 441
T V K K+QE K + E + K+E + +Q++ +TE+ +S KA
Sbjct: 474 TAVTKVVVAADKAKEQELKSRTKEVITT-KQEQMHVTHEQIRKETEKTFVPKVVISAAKA 532
Query: 442 VPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMS 501
KE++T + +EI K++ T ++ + I V A+ K + ET +
Sbjct: 533 ----KEQET--RISEEITKKQKQVTQEAIRQETEITAASMVVVATAKSTKLET-----VP 581
Query: 502 KAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKV-----QIHKQDIV-KPEKTVSHG 555
A +E + Q+ E +I KE + + KV ++ +QD+V + + ++
Sbjct: 582 GAQEETTTQQDQMHLSYE-----KIMKETRKTVVPKVIVATPKVKEQDLVSRGREGITTK 636
Query: 556 KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVT----ESG 611
+ + ++ ++ EKTA + + ++T + T + +VT + G
Sbjct: 637 REQVQITQEKMRKEAEKTALSTIAVATAKAKEQETILRTRETMATRQEQIQVTHGKVDVG 696
Query: 612 KKK-------TEISEKESKEKADMKHLREEKVSTR------KESLQLHNVTKAEKPARVS 658
KK + + +E + HL E KE + V AE P R +
Sbjct: 697 KKAEAVATVVAAVDQARVREPREPGHLEESYAQQTTLEYGYKERISAAKV--AEPPQRPA 754
Query: 659 KDVEDVPASKKAK 671
+ VP + K +
Sbjct: 755 SEPHVVPKAVKPR 767
Score = 47.8 bits (112), Expect = 4e-05
Identities = 102/509 (20%), Positives = 189/509 (37%), Gaps = 63/509 (12%)
Query: 159 QTKVTHKEKEKGKEKVREKEKPEKKATHKEKI--EKKEKPETKTLAKE--QKKAKTAEKS 214
+T T + +E+VR++ EK A K + +K ++ E K+ KE K + +
Sbjct: 452 RTTTTAVHIQPAQEQVRKEA--EKTAVTKVVVAADKAKEQELKSRTKEVITTKQEQMHVT 509
Query: 215 EEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMI 274
E+ +KE + KV +AAK KE + S +E K+K + +++ M+
Sbjct: 510 HEQIRKETEKTFVPKVVISAAKAKEQETRIS--EEITKKQKQVTQEAIRQETEITAASMV 567
Query: 275 DIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKED 334
+ K P T+Q + KE K K + + K KE++
Sbjct: 568 VVATAKSTKLETVPGAQEETTTQQDQMHLSYEKIM--KETRKTVVPKVIVATPKVKEQDL 625
Query: 335 IKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKG 394
+ + E T TK+ V+I ++ +KE K V K
Sbjct: 626 VSRGREGIT--------------TKREQVQI-----TQEKMRKEAEKTALSTIAVATAKA 666
Query: 395 KKQEKKEKHVEPAKSPKKEHSVPSDK-QVKAKTERAKEEIGAVSIKKA----VPGKKEEK 449
K+QE + E + +++ V K V K E + AV + PG EE
Sbjct: 667 KEQETILRTRETMATRQEQIQVTHGKVDVGKKAEAVATVVAAVDQARVREPREPGHLEES 726
Query: 450 TTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKP 509
+ E ++ + + + + + VP ++K + + + + ++
Sbjct: 727 YAQQTTLEYGYKERISAAKVAEPPQRPASEPHVVPKAVKPRVIQAPSETHIKTTDQKGMH 786
Query: 510 KPPQLQGKKEEKPEPQIKKEAKPAIS------EKVQIHKQD-----------IVKPEKTV 552
Q++ + E + + +P + K+ + K + I +K +
Sbjct: 787 ISSQIKKTTDLTTERLVHVDKRPRTASPHFTVSKISVPKTEHGYEASIAGSAIATLQKEL 846
Query: 553 SHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREP----PSIKTDKPKPTPKGTSEVT 608
S +K+ K VKA T+ KP++ E P P T + G
Sbjct: 847 SATSSAQKITKSVKAPTV------KPSETRVRAEPTPLPQFPFADTPDTYKSEAGVEVKK 900
Query: 609 ESGKKKTEISEKESKEKADMKHLREEKVS 637
E G T + +E E+ ++ H RE KV+
Sbjct: 901 EVGVSITGTTVRE--ERFEVLHGREAKVT 927
Score = 43.9 bits (102), Expect = 5e-04
Identities = 87/401 (21%), Positives = 156/401 (38%), Gaps = 54/401 (13%)
Query: 145 KDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKE 204
+ +TEK P+ I +++ + E++ +K+ K+ ++ + ET+ A
Sbjct: 514 RKETEKTFVPKVVISAAKAKEQETRISEEITKKQ--------KQVTQEAIRQETEITAAS 565
Query: 205 QKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQK 264
TA + TK E G QE+ ++ + K K K V+ + K
Sbjct: 566 MVVVATA----KSTKLETVPGAQEETTTQQDQMHLSYEKIMKETRKTVVPKVIVATPKVK 621
Query: 265 DQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVT 324
+Q D+ G + G + T++ R KE EK
Sbjct: 622 EQ--------DLVSRG--REGITTKREQVQITQEKMR----------KEAEKTALSTIAV 661
Query: 325 SETKKKEKEDIKKKSE------KETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKE 378
+ K KE+E I + E ++ + K + GK +E V QA ++ +
Sbjct: 662 ATAKAKEQETILRTRETMATRQEQIQVTHGKVDVGKKAEAVATVVAAVDQARVREPREPG 721
Query: 379 DSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKE-HSVPSDKQVKAKTERAKEE--IGA 435
+++ + K++ K EP + P E H VP K VK + +A E I
Sbjct: 722 HLEESYAQQTTLEYGYKERISAAKVAEPPQRPASEPHVVP--KAVKPRVIQAPSETHIKT 779
Query: 436 VSIKKAVPGKKEEKTTK-TVEQEIRKEKSGKTSS----ILKDKEP--IKGKEEKVP---- 484
K + +KTT T E+ + +K +T+S + K P G E +
Sbjct: 780 TDQKGMHISSQIKKTTDLTTERLVHVDKRPRTASPHFTVSKISVPKTEHGYEASIAGSAI 839
Query: 485 ASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQ 525
A+L+++ T +K++K+ K KP + + + E P PQ
Sbjct: 840 ATLQKELSATSSAQKITKSVKAPTVKPSETRVRAEPTPLPQ 880
Score = 38.5 bits (88), Expect = 0.022
Identities = 62/316 (19%), Positives = 118/316 (37%), Gaps = 47/316 (14%)
Query: 81 IAKIGSDPLKLVRDAMEETTDWIYGFF-----SLLSDIISSE--------------DEED 121
I K+ D L++VR A T Y F+ L DI E +EE
Sbjct: 32053 IPKLSQDDLEIVRPARRRTPSPDYDFYYRPRRRSLGDISDEELLLPIDDYLAMKRTEEER 32112
Query: 122 DDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEK-- 179
+E+ + G PP R + + + P+ ++ + T K+ + K +
Sbjct: 32113 LRLEEELELGFSASPPSRSPPHFELSSLRYSSPQAHVKVEETRKDFRYSTYHIPTKAEAS 32172
Query: 180 ---PEKKATHKEKIEKKEKPETKTLAKEQKK------AKTAEKSEEKTKKEVKGGKQEKV 230
E + H + ++ K + +A+ + + T SE K++ + K+EK
Sbjct: 32173 TSYAELRERHAQAAYRQPKQRQRIMAEREDEELLRPVTTTQHLSEYKSELDFM-SKEEKS 32231
Query: 231 KQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPA- 289
++ + + +EV + E +E+ +SKH Q++ + ++ + SP
Sbjct: 32232 RKKSRRQREVTEI------TEIEEEYEISKHAQRESSSSASRLL------RRRRSLSPTY 32279
Query: 290 --IPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDV 347
+ P+ SRP PA ++ E E+ E + E+ D+
Sbjct: 32280 IELMRPVSELIRSRPQPAEEYEDDTERRSPTPERTRPRSPSPVSSERSLSRFERSARFDI 32339
Query: 348 -EKKEPGKASETKQGT 362
+ E KA+ Q T
Sbjct: 32340 FSRYESMKAALKTQKT 32355
Score = 37.0 bits (84), Expect = 0.065
Identities = 44/201 (21%), Positives = 81/201 (40%), Gaps = 24/201 (11%)
Query: 69 DLVDYKNFSASSIAKIGSDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDT 128
D+VD K++ + +P ++ ++ F S+L E
Sbjct: 1898 DIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRR-----------APEPR 1946
Query: 129 DKGEIDEPPLRKKEIHK-----DKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKK 183
+ + EP + E+ K D TE +E + K ++TH++ + E++R K K +
Sbjct: 1947 PEFHVHEPGKLQFEVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTE 2006
Query: 184 ATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKT 243
+ E I E K +KK ++ E+ KTK E+ +E ++ + E K
Sbjct: 2007 EGYYEAITAVE-------LKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKI 2059
Query: 244 PSKPKEKEDKEKAAVSKHEQK 264
+ P K DK + + S K
Sbjct: 2060 -TIPTFKPDKIELSPSMEAPK 2079
Score = 34.3 bits (77), Expect = 0.42
Identities = 53/243 (21%), Positives = 87/243 (35%), Gaps = 30/243 (12%)
Query: 316 KKKAEKKVTS---ETKKKEKEDIKKKSEKETAIDVEKKEPG---KASETKQGTVKIAAQA 369
KK +E + +S E K + E + S E + E K K+ E K T KI
Sbjct: 32500 KKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTL 32559
Query: 370 AAKKDEKKE--------------DSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHS 415
AA+ K D+ P KG+ +H K
Sbjct: 32560 AARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFE 32619
Query: 416 VPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEP 475
+ S +A +E + + GK+E + T T+++ EK+ + +K EP
Sbjct: 32620 ISS--------VQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEP 32671
Query: 476 IKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAIS 535
E V + + K PE + +S E KP P + P+I + K S
Sbjct: 32672 RVKSPEAVKSPKRVKSPEPSHPKAVSPT--ETKPTPTEKVQHLPVSAPPKITQFLKAEAS 32729
Query: 536 EKV 538
+++
Sbjct: 32730 KEI 32732
Score = 33.5 bits (75), Expect = 0.72
Identities = 49/248 (19%), Positives = 99/248 (39%), Gaps = 25/248 (10%)
Query: 308 ALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAA 367
A + ++ E ++ + T+ KK SE E + V + + + +ET++
Sbjct: 32472 ASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVK-SQMTETRESLSSYEH 32530
Query: 368 QAAAKK-----DEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQ- 421
A+A+ +EK + K T + +++ + K + + + S +D +
Sbjct: 32531 SASAEMKSAALEEKSLEEKSTTR--KIKTTLAARILTKPRSMTVYEGESARFSCDTDGEP 32588
Query: 422 VKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEE 481
V T K ++ + S + V K + T + ++ G S ++++ E GK+E
Sbjct: 32589 VPTVTWLRKGQVLSTSARHQVTTTKYKSTFEI--SSVQASDEGNYSVVVENSE---GKQE 32643
Query: 482 ----------KVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAK 531
+V P K E K+ + VK P +++ + P+ E K
Sbjct: 32644 AEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVK-SPKRVKSPEPSHPKAVSPTETK 32702
Query: 532 PAISEKVQ 539
P +EKVQ
Sbjct: 32703 PTPTEKVQ 32710
Score = 32.3 bits (72), Expect = 1.6
Identities = 33/145 (22%), Positives = 63/145 (43%), Gaps = 21/145 (14%)
Query: 308 ALEEKEGEKKKAEK--KVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKI 365
A+++ E +K +K ++T + K +E+I +K+ + I K SE K
Sbjct: 32943 AIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEI--------KMSEAK------ 32988
Query: 366 AAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKA- 424
+ +K KE++ K EV++ EK H E K+ + V + ++KA
Sbjct: 32989 ----SQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAF 33044
Query: 425 KTERAKEEIGAVSIKKAVPGKKEEK 449
T+ + E + +K + G + K
Sbjct: 33045 STQMSINEGQRLVLKANIAGATDVK 33069
Score = 31.6 bits (70), Expect = 2.7
Identities = 32/112 (28%), Positives = 52/112 (46%), Gaps = 11/112 (9%)
Query: 141 KEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKT 200
K+ K Q+ E Q K +E E ++ +R +E +A +EK+ KE+
Sbjct: 32945 KDTEAQKVSTQKTSEITPQKKAVVQE-EISQKALRSEEIKMSEAKSQEKLALKEEASKVL 33003
Query: 201 LAKEQKK--AKTAEKS---EEKTK-----KEVKGGKQEKVKQTAAKVKEVQK 242
+++E KK A + EKS EE TK +EV+ + K T + E Q+
Sbjct: 33004 ISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQR 33055
Score = 30.0 bits (66), Expect = 7.9
Identities = 25/112 (22%), Positives = 45/112 (40%), Gaps = 15/112 (13%)
Query: 297 EQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKAS 356
++ RP + E KE K K +++T E +E E+++ K ++ T
Sbjct: 1962 QKVDRPVDTT---ETKEVVKLKRAERITHEKVPEESEELRSKFKRRT------------E 2006
Query: 357 ETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAK 408
E + + KKDE E+ + K + K +E+K+ E K
Sbjct: 2007 EGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGK 2058
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 105 bits (262), Expect = 1e-22
Identities = 130/584 (22%), Positives = 262/584 (44%), Gaps = 80/584 (13%)
Query: 90 KLVRDAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTE 149
K +++A+E ++ + S + D +E T+K E E + EI + +T
Sbjct: 109 KRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETV 168
Query: 150 KQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAK 209
+ + + +K+++K KE+ E+EKP++ + + ++E E KT +++
Sbjct: 169 TKSYQKNDWRDAEENKKEDKEKEE-EEEEKPKRGSIGENQVE--VMVEEKTTESQEETVV 225
Query: 210 TAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAF 269
+ K+ + + +E K ++E+ +Q + ++ +K + KE+ + E+A + E++
Sbjct: 226 MSLKNGQISSEEPK--QEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERE----- 278
Query: 270 CRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPAS--PALEEKEGEKKKAEKKVTSET 327
+K Q I +A A E +E E+ + E+K +E
Sbjct: 279 -----------RIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEE 327
Query: 328 KKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPA 387
+++ KE+ K+ +E+ I K+E +A+E +Q K++EK+ ++ + A
Sbjct: 328 RQRIKEEEKRAAEERQRI---KEEEKRAAEERQ---------RIKEEEKRAAEERQRARA 375
Query: 388 EVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGA--VSIKKAVPGK 445
E E+ +++K+ K +E +K+H++ ++ K K E+ +++I V+ KKA
Sbjct: 376 EEEEKAKVEEQKRNKQLE-----EKKHAM---QETKIKGEKVEQKIEGKWVNEKKA---- 423
Query: 446 KEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDE-KMSKAG 504
+E+K V ++ +EK K ++ K EK L+E +P KK+E K K
Sbjct: 424 QEDKLQTAVLKKQGEEKGTK----------VQAKREK----LQEDKPTFKKEEIKDEKIK 469
Query: 505 KEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQ 564
K+ +PK +K ++K + ++ K++ + +P S E + Q
Sbjct: 470 KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 529
Query: 565 VKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTE-----ISE 619
V+A K ++ R E S + +K K + + E KKK E + E
Sbjct: 530 VEA--------GKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE 581
Query: 620 KESK---EKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKD 660
+E + E+AD K EE+ KE ++ AEK ++ +D
Sbjct: 582 EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 625
Score = 101 bits (252), Expect = 2e-21
Identities = 131/592 (22%), Positives = 263/592 (44%), Gaps = 67/592 (11%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVRE 176
+ +E++ + TD+ E++ ++ +E T+V ++ E++
Sbjct: 52 QKQEEESLGQVTDQVEVNA---------QNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR 102
Query: 177 KEKPEKKATHKEKIEKKEKPETKT---LAKEQKKAKTAEKSEEKTKKEVKG-GKQEK--V 230
+E+ +K + +KE T T L+ ++ + E T+KE K +QE+ +
Sbjct: 103 REERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEI 162
Query: 231 KQTAAKVKEVQKTPSKPKE---KEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQS 287
++T K QK + E KEDKEK + E+ + + +++ V Q
Sbjct: 163 EETETVTKSYQKNDWRDAEENKKEDKEKEE-EEEEKPKRGSIGENQVEVMVEEKTTESQE 221
Query: 288 PAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDV 347
+ L Q S P K+ E+++ S +K E+ED ++ + ++
Sbjct: 222 ETVVMSLKNGQISSEEP-------KQEEEREQGSDEISHHEKMEEEDKERAEAERARLEA 274
Query: 348 EKKEPGKASETKQ-----GTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEK 402
E++E KA + K+ ++ +AAA++ E++E ++ + E ++ ++Q KE+
Sbjct: 275 EERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEE 334
Query: 403 HVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEK 462
A+ +++ +K+ + +R KEE + ++ +EE+ K EQ+ K+
Sbjct: 335 EKRAAE--ERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQL 392
Query: 463 SGKTSSILKDKEPIKGKEEKVPASLKEKEPETKK--DEKMSKA--GKEVKPKPPQLQGKK 518
K ++ + K IKG EKV ++ K KK ++K+ A K+ + K ++Q K+
Sbjct: 393 EEKKHAMQETK--IKG--EKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKR 448
Query: 519 E--EKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIE-KTAK 575
E ++ +P KKE EK++ K+ P++ V +K +VK+ E T K
Sbjct: 449 EKLQEDKPTFKKE--EIKDEKIKKDKE----PKEEVKSFMDRKKGFTEVKSQNGEFMTHK 502
Query: 576 PKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEI----SEKESKEKADMKHL 631
K T+ R S+ T + + P+ E+GK+ E+ E ES+E +K
Sbjct: 503 LKHTENTFSRPGGRASVDTKEAEGAPQ-----VEAGKRLEELRRRRGETESEEFEKLKQK 557
Query: 632 REEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQK 683
++E +L+L + K + R K +E+ +K +E + ++K
Sbjct: 558 QQE------AALELEELKKKREERR--KVLEEEEQRRKQEEADRKLREEEEK 601
Score = 97.8 bits (242), Expect = 3e-20
Identities = 134/606 (22%), Positives = 266/606 (43%), Gaps = 81/606 (13%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPER------KIQTKVTHKEKEKG 170
E EE + + K + + KKE + + E++EKP+R +++ V K E
Sbjct: 161 EIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQ 220
Query: 171 KEKV-----------------REKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEK 213
+E V E+E+ + +H EK+E+++ KE+ +A+ A +
Sbjct: 221 EETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEED--------KERAEAERA-R 271
Query: 214 SEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYM 273
E + ++ +K + +K+ A+++ +K ++ +E+ + E+ + E+K + A R
Sbjct: 272 LEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEK-RAAEERQR 330
Query: 274 IDIFVHGDLKPGQSPAIPPPLPTEQASR-PTPASPALEEKEGEKKKAEKKVTSETKKKEK 332
I + Q E+ R A EE++ + + E+K E +K+ K
Sbjct: 331 IKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNK 390
Query: 333 E-DIKKKSEKETAI---DVEKKEPGK-ASETKQGTVKIAAQAAAKKDEKKEDSKKTKK-P 386
+ + KK + +ET I VE+K GK +E K K+ K+ E+K + K+
Sbjct: 391 QLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREK 450
Query: 387 AEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKK 446
+ ++P KK+E K++ ++ K PK+E VK+ +R K G +K
Sbjct: 451 LQEDKPTFKKEEIKDEKIKKDKEPKEE--------VKSFMDRKK---GFTEVKSQ---NG 496
Query: 447 EEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKE 506
E T K E + G +S+ D + +G + V A + +E ++ E S+ ++
Sbjct: 497 EFMTHKLKHTENTFSRPGGRASV--DTKEAEGAPQ-VEAGKRLEELRRRRGETESEEFEK 553
Query: 507 VKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVK 566
+K K + + EE + ++E + + E+ Q KQ+ + + K+ ++ +
Sbjct: 554 LKQKQQEAALELEELKKK--REERRKVLEEEEQRRKQE-----------EADRKLREEEE 600
Query: 567 AVTIEKTAKPKPTKKAEHREREPPSIKTDKPKP----TPKGTS-EVTESGKKKTEISEKE 621
+++ + + + AE R++ P +D KP TPKG+S ++ E + + +K
Sbjct: 601 KRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKS 660
Query: 622 SKEKADMKHLREEKVSTRKES-LQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPT 680
S K+ + K+ +R E TK+ KP + + VPA EG ++
Sbjct: 661 SGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPA-----EGVRNIKSM 715
Query: 681 KQKSPI 686
+K +
Sbjct: 716 WEKGNV 721
Score = 97.4 bits (241), Expect = 4e-20
Identities = 126/600 (21%), Positives = 260/600 (43%), Gaps = 60/600 (10%)
Query: 94 DAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEK 153
++ EET + S+ E+E + DE + +++E + E + + E +E+
Sbjct: 218 ESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEER 277
Query: 154 PERKIQTK---VTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKT 210
K + + + + +EK +E+ ++A +E++ ++EK + + +++ K
Sbjct: 278 ERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKR 337
Query: 211 AEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEK---EDKEKAAVSKHEQKDQY 267
A + ++ K+E K +E+ ++KE +K ++ +++ E++EKA V + ++ Q
Sbjct: 338 AAEERQRIKEEEKRAAEER-----QRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQL 392
Query: 268 AFCRY-MIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSE 326
++ M + + G+ K Q I E+ ++ A+ +K+GE+K + + E
Sbjct: 393 EEKKHAMQETKIKGE-KVEQK--IEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKRE 449
Query: 327 TKKKEKEDIKKKSEKETAI--DVEKKEPGKA-SETKQGTVKIAAQAAAKKDEKKEDSKKT 383
+++K KK+ K+ I D E KE K+ + K+G ++ +Q K + ++ T
Sbjct: 450 KLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENT 509
Query: 384 ------KKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVS 437
+ + ++ +G Q + K +E + + E +++K K + A E+ +
Sbjct: 510 FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELK 569
Query: 438 IKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKD 497
KK E+ K +E+E ++ K + L+++E + +E++ + + +K
Sbjct: 570 -------KKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIE---RRRAEAAEKR 619
Query: 498 EKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKP 557
+KM + G KP + K +K E + K + K VK +
Sbjct: 620 QKMPEDGLSDDKKPFKCFTPKGS----SLKIEERAEFLNK-SVQKSSGVKSTHQAAIVSK 674
Query: 558 EEKVLKQVKAVTIEKTAKPKPTKKAEHREREPP----SIKTDKPK------PTPKGTSEV 607
+ L+Q + IE T KPTK A P +IK+ K PT GT
Sbjct: 675 IDSRLEQYTS-AIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNK 733
Query: 608 TESGKK---KTEISEKESKEKADMK-------HLREEKVSTRKESLQLHNVTKAEKPARV 657
+G K + I+E +K K LR VS+++ + +V K P +V
Sbjct: 734 ETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 793
Score = 58.5 bits (140), Expect = 2e-08
Identities = 69/393 (17%), Positives = 178/393 (45%), Gaps = 34/393 (8%)
Query: 310 EEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQA 369
+++E + +AE+ E+E +++ + + +K+ ++ V++ AQ
Sbjct: 13 QKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQN 72
Query: 370 AAKKDEKKEDSKKTKKPAEVE----QPKGKKQEKKEKHVEPAKSPKKEH---------SV 416
+ +E K + T+ + E + +++E+++K ++ A +KE S+
Sbjct: 73 SVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSL 132
Query: 417 PSDKQVK--AKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQ-EIRKEKSGKTSSILKDK 473
PS + A+ E ++E + S ++ ++ E TK+ ++ + R + K +DK
Sbjct: 133 PSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKK----EDK 188
Query: 474 EPIKGKEEKVP-ASLKEKEPETKKDEKMSKAGKE---VKPKPPQLQGKKEEKPEPQIKKE 529
E + +EEK S+ E + E +EK +++ +E + K Q+ ++ ++ E + +
Sbjct: 189 EKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGS 248
Query: 530 AKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREP 589
+ + EK++ ++ + E+ + E++ + ++ A+ + +KA +ERE
Sbjct: 249 DEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERE- 307
Query: 590 PSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVT 649
+ + + E + +++ I E+E + + + ++EE+ +E ++
Sbjct: 308 ----RREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRI---- 359
Query: 650 KAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQ 682
E+ R +++ + A ++ K E+ KQ
Sbjct: 360 -KEEEKRAAEERQRARAEEEEKAKVEEQKRNKQ 391
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 105 bits (262), Expect = 1e-22
Identities = 142/628 (22%), Positives = 275/628 (43%), Gaps = 98/628 (15%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEK----EKGKE 172
++++ D DED E++E L + I D+ KP + + T K+K +KGK+
Sbjct: 46 KEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKK 105
Query: 173 KVREKEKPEKKATHKEKIEKKEKPETKTLAKEQ------KKAKTAEKSEEKTKKEVKGGK 226
+ + E+ K +K KP+ + + K K A+ +K+ K+ G +
Sbjct: 106 QSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSE 165
Query: 227 QEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQ 286
+++ + K+KE + S + ++ ++ S+ QK KPG
Sbjct: 166 EDE--DNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKN-------------KPGP 210
Query: 287 SPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKK-KEKEDIKKKSEKETAI 345
+ E + AS + K +KKAEKK K+ +EK ++K EKE +
Sbjct: 211 N--------IESGNEDDDAS--FKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKE-EL 259
Query: 346 DVEKKEPGKASETKQ---------------GTVKIAAQAAAKKDEKKEDSKKTKKPAEVE 390
+ KK+ K E+++ G + + + A ++D++ KK + +
Sbjct: 260 ETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKK 319
Query: 391 QPKGKKQEK-KEKHVEPAKSPKK--EHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKE 447
+ KG+K+EK KEK P+K+ K + ++ K+ + + +R +EE IK+ + +
Sbjct: 320 KKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEE----RIKRLEELEAK 375
Query: 448 EKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKA-GKE 506
K + +EQE R+ K K + KE +K + + + S +E + K+ +A G E
Sbjct: 376 RKEEERLEQEKRERKKQKEK---ERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVE 432
Query: 507 VKPKP------PQLQGKKEEK-PEPQIKKEAKPA--ISEKVQIHKQDIVKPEKTVSHGKP 557
V K P + KK +K P+ KE + + V++ +Q + + E+T +P
Sbjct: 433 VPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEP 492
Query: 558 EE------------------KVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKP 599
EE + ++V+ + K P ++ E E E ++++ +
Sbjct: 493 EEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEE-EE 551
Query: 600 TPKGTSEVTESGKKKTEIS-EKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVS 658
+G SE +E ++ ++S EK+S + D K +E +S+ E + TK E+ +
Sbjct: 552 EEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKE--MSSDSEYDSDDDRTKEER----A 605
Query: 659 KDVEDVPASKKAKEGTEDVSPTKQKSPI 686
D K+ E +++V+ K ++PI
Sbjct: 606 YDKAKRRIEKRRLEHSKNVNTEKLRAPI 633
Score = 77.8 bits (190), Expect = 3e-14
Identities = 89/373 (23%), Positives = 162/373 (43%), Gaps = 65/373 (17%)
Query: 115 SSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKV 174
S E E ED ++G+ + +KK+ K++ EK++K K +K T K ++ K+
Sbjct: 295 SEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKK---KGPSKATVKAMQEALAKL 351
Query: 175 REKEKPEKKATHK-----EKIEKKEKPETK--TLAKEQKKAKTAEKSEE---------KT 218
+E+E+ +K+ + E++E K K E + +E+KK K E+ E K+
Sbjct: 352 KEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKS 411
Query: 219 KKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEK---EDKEKAAVSKH----EQKDQYAFCR 271
++E + + +K A+ EV S PK++ EDK++ + + E + C
Sbjct: 412 QREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCA 471
Query: 272 YMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPAS----PALEEKEGEKKKAEKKVTSET 327
+++ G + PPP+ E+ A A+ E +K KV E
Sbjct: 472 -AVEVMEQG---VPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEV 527
Query: 328 KKK-EKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKP 386
K+ E+E+ +++ E+E E++E SE +G ++DEK D
Sbjct: 528 KENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGD---------EEDEKVSD------- 571
Query: 387 AEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKK 446
E+ GK +KK P KE S SD + + +R KEE K+ + ++
Sbjct: 572 ---EKDSGKTLDKK---------PSKEMS--SDSEYDSDDDRTKEERAYDKAKRRIEKRR 617
Query: 447 EEKTTKTVEQEIR 459
E + +++R
Sbjct: 618 LEHSKNVNTEKLR 630
Score = 73.9 bits (180), Expect = 5e-13
Identities = 101/494 (20%), Positives = 217/494 (43%), Gaps = 55/494 (11%)
Query: 209 KTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYA 268
K KSE+ TK ++ + A KE + SK K+K++K+K + + +
Sbjct: 4 KQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELE 63
Query: 269 FCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETK 328
+ + G ++ A+ P E+ ++K+G+K K + ++++
Sbjct: 64 ----ELSLEAQGIKADRETVAVKPTENNEEEFTSKD-----KKKKGQKGKKQSFDDNDSE 114
Query: 329 KKEKEDIKKKSEKETAIDV-----EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKT 383
+ E +D K K + +++ + + K + +G + + + +E +++SKK
Sbjct: 115 ELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKI 174
Query: 384 KKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTE--RAKEEIGAVSIKKA 441
K+ + + G+ ++ ++ ++ K KK +++ E A +I V+ KKA
Sbjct: 175 KERSRINS-SGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKA 233
Query: 442 VPGKKEEKTTKTVEQEIRKEK------SGKTSSILKDKEPIKGKEEKVPASL-------- 487
++E K + ++RK K +GK + + K +EE V + +
Sbjct: 234 EKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIP 293
Query: 488 -KEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIV 546
E++ ET + G + K + +G+KEEK + + K +K V+ ++ +
Sbjct: 294 ASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKAT----VKAMQEALA 349
Query: 547 KPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSE 606
K ++ K EE+ +++K + E AK K ++ E +RE K + K
Sbjct: 350 KLKEEEERQKREEE--ERIKRLE-ELEAKRKEEERLEQEKRERKKQKEKERK------ER 400
Query: 607 VTESGKKKTEISEKESKEKAD--MKHLREEKVST-RKESLQLHNVTKAEKPARVSKDVED 663
+ + GK T+ S++E++ +A+ +K L+ + V K+SL ++P K +
Sbjct: 401 LKKEGKLLTK-SQREARARAEATLKLLQAQGVEVPSKDSL------PKKRPIYEDKKRKK 453
Query: 664 VPASKKAKEGTEDV 677
+P ++KE +E +
Sbjct: 454 IPQQLESKEVSESM 467
Score = 62.4 bits (150), Expect = 1e-09
Identities = 82/348 (23%), Positives = 129/348 (37%), Gaps = 46/348 (13%)
Query: 368 QAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTE 427
Q +D K+D AE+E K+++ +K K KK+ D +K E
Sbjct: 5 QKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64
Query: 428 RAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASL 487
+ E G + ++ V K E + + +K+K K D + E+K S
Sbjct: 65 LSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSK 124
Query: 488 KEKEPETK------KDEKMSKAGKEVKPKPPQLQGKK---EEKPEPQIKK---------- 528
K +P+ + D+ +K K+ K K Q KK E+ E KK
Sbjct: 125 KTAKPKVEMYSGSDDDDDFNKLPKKAKGK-AQKSNKKWDGSEEDEDNSKKIKERSRINSS 183
Query: 529 -----EAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAE 583
E+ + + K KP + G ++ ++K V KKAE
Sbjct: 184 GESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVA---------QKKAE 234
Query: 584 HREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTR---K 640
+ERE +K K E E+GKK +SK+K + EE V ++
Sbjct: 235 KKERERKKRDEEKAKLRKLKEKEELETGKK------DQSKQKESQRKFEEETVKSKVTVD 288
Query: 641 ESLQLHNVTKAEKPARVSKDVE--DVPASKKAKEG-TEDVSPTKQKSP 685
+ + KAE P D E KK K+G E+ K+K P
Sbjct: 289 TGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGP 336
Score = 58.2 bits (139), Expect = 3e-08
Identities = 67/309 (21%), Positives = 131/309 (42%), Gaps = 39/309 (12%)
Query: 114 ISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEK 173
+ E+E +E+ K ++E ++KE ++ +QEK ERK Q + KE+ K + K
Sbjct: 351 LKEEEERQKREEEERIK-RLEELEAKRKE---EERLEQEKRERKKQKEKERKERLKKEGK 406
Query: 174 VREKEKPEKKATHKEKIE-----------KKEKPETKTLAKEQKKAKTAEKSEEKTKKE- 221
+ K + E +A + ++ K P+ + + +++K+ K ++ E K E
Sbjct: 407 LLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSES 466
Query: 222 VKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGD 281
++ +V + KE P +P+E+ED E A + E + VH +
Sbjct: 467 MELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIE 526
Query: 282 LKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEK 341
+K P E+ EE E +++ E++ SE + ++ED K EK
Sbjct: 527 VKEN---------PEEEEEEEEEE----EEDEESEEEEEEEGESEGSEGDEEDEKVSDEK 573
Query: 342 ETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKE 401
++ ++KK + S ++ + D KE+ K +E K + + K
Sbjct: 574 DSGKTLDKKPSKEMSSD--------SEYDSDDDRTKEERAYDKAKRRIE--KRRLEHSKN 623
Query: 402 KHVEPAKSP 410
+ E ++P
Sbjct: 624 VNTEKLRAP 632
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 103 bits (256), Expect = 7e-22
Identities = 138/578 (23%), Positives = 237/578 (41%), Gaps = 100/578 (17%)
Query: 131 GEIDEPPLRKKEIHK--DKTEKQEKPERKIQTKVTHKE-KEKGKE--KVREKEKPEKKAT 185
G++ P +++ ++ + D E + + + +K KE KE+ E KV EKP K +
Sbjct: 523 GQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVES 582
Query: 186 HKEKIEKKEKP-ETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQK-T 243
++ + KK+KP +T+T +K +++ K EV + VK AAK K V+K T
Sbjct: 583 KEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKET 642
Query: 244 PSKPKE-KEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRP 302
KP++ KE+KEK P ++ ++
Sbjct: 643 KVKPEDKKEEKEK---------------------------------------PKKEVAKK 663
Query: 303 TPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGT 362
+P +E++ +K++ +K+V E KK+EK++ KK+ +KET KKE K E K+
Sbjct: 664 EDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKK--EEKKEV 721
Query: 363 VKIAAQAAAKKDEKK--EDSKKT-------KKPAEVEQPKGKKQEKKEKHVEPAKSPKKE 413
K + KK+ KK +D+KK+ KKPA ++ KK+E +K A PK++
Sbjct: 722 KK--EEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEK 779
Query: 414 HSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKE-EKTTKTVEQEIRKEKSGKTSSILKD 472
+ K+ E +G + AV E E + + KD
Sbjct: 780 GKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKD 839
Query: 473 KEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKP-------KPPQLQGKKEEKPEPQ 525
E +K +E V +K + + +EK+ KE +P K ++ E P+
Sbjct: 840 FEELKAEEVDVTKDIKPQLELIEDEEKL----KETEPVEAYVIQKEREVTKGPAESPDEG 895
Query: 526 I-----KKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLK----QVKAVTIE----- 571
I + E + E + KQ + EK G E+ + + KA T E
Sbjct: 896 ITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPE 955
Query: 572 ---------KTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTES-----GKKKTEI 617
+K PT+ E + E + +K + G E K + E
Sbjct: 956 EDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQ 1015
Query: 618 SEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPA 655
SE+E+ E+ + REE+ K + + + +K A
Sbjct: 1016 SEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAA 1053
Score = 96.3 bits (238), Expect = 9e-20
Identities = 144/577 (24%), Positives = 241/577 (41%), Gaps = 75/577 (12%)
Query: 169 KGKEKVREKE-KPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQ 227
+G EK++ + + AT K+ + P K Q K K S E K K
Sbjct: 500 EGLEKLKHLDFLKQPLATQKDLTGQVPTPVVK-----QTKLKQRADSRESLKPAAKPLPS 554
Query: 228 EKV-KQTAAKVKEVQKTP--SKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKP 284
+ V K++ + EV K KP + E KEK V K + +K
Sbjct: 555 KSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKP------------------IKT 596
Query: 285 GQSPAIPPP-LPTEQASRPTPASPALEEKEGEKKKA--EKKVTSETKKK--EKEDIKKKS 339
P++ +P+++ P A A ++ K KA EK V ETK K +K++ K+K
Sbjct: 597 ETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKP 656
Query: 340 EKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKK---PAEVEQPKGKK 396
+KE A +K K + K+ VK + KK+EKKE K+ KK P EV++ + KK
Sbjct: 657 KKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKK-EVKK 715
Query: 397 QEKKEKHVEPAKSPKKE-HSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVE 455
+EKKE E K PKKE +P D K + E ++K VP KKEE K
Sbjct: 716 EEKKEVKKE-EKEPKKEIKKLPKD--AKKSSTPLSEAKKPAALKPKVP-KKEESVKKDSV 771
Query: 456 QEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQ 515
+ ++ GK I K+ GK + A+ T M+ AG +L+
Sbjct: 772 AAGKPKEKGKIKVIKKE-----GKAAEAVAAAVGTGATTA--AVMAAAGIAAIGPAKELE 824
Query: 516 GKKEEKPEPQ-IKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTA 574
++ P+ + K+ + +E+V + K +KP+ + + + K + V+A I+K
Sbjct: 825 AERSLMSSPEDLTKDFEELKAEEVDVTKD--IKPQLELIEDEEKLKETEPVEAYVIQK-- 880
Query: 575 KPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEK--ESKEKADMKHLR 632
E + P+ D+ T +G E ++ ++ + ++ + EK + +
Sbjct: 881 --------EREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAG 932
Query: 633 EEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKSPISFFQCV 692
E+ S + + +AE+P ++ V ASK + TED K ++
Sbjct: 933 FEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSP--TEDEESAKAEA-------- 982
Query: 693 YLDGYNGYGFQFPFTPADRPGESSGQANSPGQKQQGQ 729
D Y + + DR E +A G+ +Q +
Sbjct: 983 --DAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSE 1017
Score = 87.8 bits (216), Expect = 3e-17
Identities = 145/641 (22%), Positives = 248/641 (38%), Gaps = 77/641 (12%)
Query: 114 ISSEDEEDDDGDEDTDKGEIDEPPLRKKEIH---------KDKTEKQEKPERKI-----Q 159
+ S++E E +K D P KE +DK E++EKP++++ +
Sbjct: 607 VPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDK 666
Query: 160 TKVTHKEKEKGKEKVREKEKPEKKATHKE--KIEKKEKPETKTLAKEQKK--AKTAEKSE 215
T + +EK K +E +E +K KK KE K KKE P K + KE KK K +K E
Sbjct: 667 TPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETP-PKEVKKEVKKEEKKEVKKEE 725
Query: 216 EKTKKEVKGGKQEKVKQTAAKVKEVQK----TPSKPKEKE-------------DKEKAAV 258
++ KKE+K ++ K+++ + E +K P PK++E +K K V
Sbjct: 726 KEPKKEIKKLPKD-AKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKV 784
Query: 259 SKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKK 318
K E K A + + A P +A R +SP K+ E+ K
Sbjct: 785 IKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELK 844
Query: 319 AEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKE 378
AE+ ++ K + E I+ + + + VE K E +G + + + + E
Sbjct: 845 AEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGE 904
Query: 379 DSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAK------EE 432
+ P E+E + + + EK E + +E S D + KA+TE A+ EE
Sbjct: 905 CE---QTPEELEPVEKQGVDDIEK-FEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEE 960
Query: 433 IGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEP 492
VS K P + EE + IR+++ S + +E + EK A E+E
Sbjct: 961 HVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEA 1020
Query: 493 ETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTV 552
+ +E ++ +E + +P +++ E+ + K A+ +E+ + P K +
Sbjct: 1021 D---EEDKAEDAREEEYEPEKMEA--EDYVMAVVDKAAEAGGAEE---QYGFLTTPTKQL 1072
Query: 553 SHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGK 612
P + + T+ ++ + T E + P T T T E
Sbjct: 1073 GAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFT----ATSGYTQSTIEISS 1128
Query: 613 KKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAE---------KPARVSK---- 659
+ T + E + E+ T S + N+TK E KPA V+
Sbjct: 1129 EPTPMDEMSTPRDVMSDETNNEE--TESPSQEFVNITKYESSLYSQEYSKPADVTPLNGF 1186
Query: 660 ---DVEDVPASKKAKEGTEDVSPTKQKSPISFFQCVYLDGY 697
D K +SP F + D Y
Sbjct: 1187 SEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAY 1227
Score = 51.2 bits (121), Expect = 3e-06
Identities = 37/132 (28%), Positives = 61/132 (46%), Gaps = 12/132 (9%)
Query: 291 PPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKK--KEKEDIKKKSEKETAIDVE 348
PPP P + S P+P P + + E E+ + KK KEK KK K +
Sbjct: 2200 PPPAPVQDRS-PSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPV 2258
Query: 349 KKEPGKA---------SETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEK 399
KK GK+ + K+ + K++ A+ KK E E + K EV+ +G++++K
Sbjct: 2259 KKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDK 2318
Query: 400 KEKHVEPAKSPK 411
+ K+ A + K
Sbjct: 2319 ETKNAANASASK 2330
Score = 42.0 bits (97), Expect = 0.002
Identities = 51/253 (20%), Positives = 91/253 (35%), Gaps = 30/253 (11%)
Query: 371 AKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTER-- 428
A ++ +E K + P G KQ+ ++ P S + +D V +TE
Sbjct: 2111 ASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECP 2170
Query: 429 ---------AKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPI--- 476
+++E + K V K + V+ + S + + I
Sbjct: 2171 SITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQN 2230
Query: 477 --KGKEEKVPASLKEKEP--ETKKDEKMSKAGKEVKP--KPPQLQGKKEEKPEPQIKKEA 530
K ++ + K K+P +TK + K+ + KP P+ G KE ++ + A
Sbjct: 2231 LGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKES--SDKVSRVA 2288
Query: 531 KPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPP 590
P E V+ + PE + G+ ++K K + K+AK P
Sbjct: 2289 SPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATA--------GPG 2340
Query: 591 SIKTDKPKPTPKG 603
+ KT K P G
Sbjct: 2341 TTKTTKSSAVPPG 2353
Score = 39.7 bits (91), Expect = 0.010
Identities = 36/124 (29%), Positives = 55/124 (44%), Gaps = 21/124 (16%)
Query: 189 KIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPK 248
K + KEK +TK + K + +KS+ K+K K +K+++ KV V + PK
Sbjct: 2236 KKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRV----ASPK 2291
Query: 249 EKEDKEKAA---------VSKHEQKDQ--------YAFCRYMIDIFVHGDLKPGQSPAIP 291
+KE EKAA ++ E+KD+ A G K +S A+P
Sbjct: 2292 KKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVP 2351
Query: 292 PPLP 295
P LP
Sbjct: 2352 PGLP 2355
Score = 38.1 bits (87), Expect = 0.029
Identities = 53/212 (25%), Positives = 77/212 (36%), Gaps = 38/212 (17%)
Query: 489 EKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKP 548
E E ET +K + K + P P +Q + P + +V P
Sbjct: 2181 EDESETIPTDK-TVTYKHMDPPPAPVQDRSPSPRHPDVS-----------------MVDP 2222
Query: 549 EKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKP---KPTPKGTS 605
E E+ + K +K EKT KP K + S KP P P G
Sbjct: 2223 EALAI----EQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLK 2278
Query: 606 EVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVP 665
E ++ + +KES EKA K +T E + E+ + +K+ +
Sbjct: 2279 ESSDKVSRVASPKKKESVEKA-------AKPTTTPEV----KAARGEEKDKETKNAANAS 2327
Query: 666 ASKKAKEGTEDVSPTK--QKSPISFFQCVYLD 695
ASK AK T TK + S + VYLD
Sbjct: 2328 ASKSAKTATAGPGTTKTTKSSAVPPGLPVYLD 2359
Score = 37.0 bits (84), Expect = 0.065
Identities = 58/245 (23%), Positives = 89/245 (36%), Gaps = 23/245 (9%)
Query: 286 QSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKK----KEKEDIKKKSEK 341
QS PPP +Q R +P E + + V ET++ +I + E
Sbjct: 2125 QSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDES 2184
Query: 342 ETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKE 401
ET I +K K + V+ + + D D + +EQ GK +K
Sbjct: 2185 ET-IPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVD----PEALAIEQNLGKALKKDL 2239
Query: 402 KHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKE 461
K E K+ K S VK ++K A S K A + +K ++ +
Sbjct: 2240 K--EKTKTKKPGTKTKSSSPVKKSDGKSKPL--AASPKPAGLKESSDKVSRVASPK---- 2291
Query: 462 KSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKK--DEKMSKAGKEVKPKPPQLQGKKE 519
K S+ K +P E K A +EK+ ETK + SK+ K P + K
Sbjct: 2292 ---KKESVEKAAKPTTTPEVKA-ARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKS 2347
Query: 520 EKPEP 524
P
Sbjct: 2348 SAVPP 2352
Score = 31.2 bits (69), Expect = 3.6
Identities = 18/64 (28%), Positives = 28/64 (43%)
Query: 157 KIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEE 216
K+ + K+KE ++ + PE KA E+ +K+ K A + K TA
Sbjct: 2283 KVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTT 2342
Query: 217 KTKK 220
KT K
Sbjct: 2343 KTTK 2346
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 102 bits (253), Expect = 2e-21
Identities = 118/439 (26%), Positives = 194/439 (44%), Gaps = 67/439 (15%)
Query: 114 ISSEDEEDDDGDEDTDKGEIDE--------------PPLRKKEIHKDKTEKQEKPERKIQ 159
+S ++E+ + +E ++ E +E P ++++E K++ E QE+ E + +
Sbjct: 106 VSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE 165
Query: 160 TKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTK 219
+ + +E G EK EK E + E + E E + AKE+KK + EKSEE
Sbjct: 166 GAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAE--AKEEKKVE--EKSEEVAT 221
Query: 220 KEVKGGKQEKVKQTAAKVKEVQK----TPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMID 275
KE E V AKV++ +K P P E++ K S E+K + + ++
Sbjct: 222 KE------ELVAD--AKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 273
Query: 276 IFVHGDL------KPGQSPAIPPPLPTEQASRPTPASPALEEK------EGEKKKAEKKV 323
+ + G+SP P+ E+A P P SP E K +GE+K+ E+K
Sbjct: 274 EKGKSPVPKSPVEEKGKSPVSKSPV-EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKE 332
Query: 324 TSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEK--KEDSK 381
E K+EK ++KK EK + +KK E V ++ EK KE+ K
Sbjct: 333 VKEAPKEEK--VEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGK 390
Query: 382 KTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPS---------DKQVKAKTERAKEE 432
++ E E+ G+ ++E + AK +KE + +++ K K +EE
Sbjct: 391 PLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 450
Query: 433 IGAV--------SIKKAVPGKKEEK--TTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEK 482
G V + +K K EEK TKTVE+ + G T I K + K E+
Sbjct: 451 KGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITK-SVTVTQKVEE 509
Query: 483 VPASLKEKEPETKKDEKMS 501
+ +EK TKK EK++
Sbjct: 510 HEETFEEKLVSTKKVEKVT 528
Score = 94.4 bits (233), Expect = 3e-19
Identities = 136/516 (26%), Positives = 220/516 (42%), Gaps = 50/516 (9%)
Query: 153 KPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPE-----TKTLA---KE 204
+P I +K+ + E K KV+ K E K + EK E E T+ LA KE
Sbjct: 51 RPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKE 110
Query: 205 QKKAKTAEKSEE-KTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPK-EKEDKEKAAVSKHE 262
+KK EK EE + ++E K+ VK TA +VKE + + + ++E++E+ +K +
Sbjct: 111 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSD 170
Query: 263 QKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEG--EKKKAE 320
Q ++ G K G S EQ T A EE E EKK E
Sbjct: 171 QAEE------------GGSEKEGSSEKEEG----EQEEGETEAEAEGEEAEAKEEKKVEE 214
Query: 321 KKVTSETKKKEKEDIKKKSEKETAIDVEK---KEPGKASETKQGTVKIAAQAAAKKDEKK 377
K TK++ D K + ++ V K +E GK S + V+ ++ K +
Sbjct: 215 KSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGK-SPVPKSPVEEKGKSPVPKSPVE 273
Query: 378 EDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVS 437
E K + VE+ KGK K E AKSP + V ++ K+K E K E
Sbjct: 274 EKGKSPVPKSPVEE-KGKSPVSKSPVEEKAKSPVPKSPV---EEAKSKAEVGKGEQKEEE 329
Query: 438 IKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLK-EKEPETKK 496
K+ KEEK K ++E K+ K + KE + + S+K E ETK+
Sbjct: 330 EKEVKEAPKEEKVEK--KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKE 387
Query: 497 DEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIH-KQDIVKPEKTVSHG 555
+ K + KE K K G +EE + K K I+ ++ K+++ + K G
Sbjct: 388 EGKPLQQEKE-KEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSG 446
Query: 556 KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKT 615
+ EEK + + + + K K+E + +++ K T +G T+ K
Sbjct: 447 REEEKGVV-TNGLDLSPADEKKGGDKSEEKVVVTKTVE----KITSEGGDGATKYITKSV 501
Query: 616 EISEKESKEKADMKHLREEKVSTRK-ESLQLHNVTK 650
+++K + + + E+ VST+K E + H + K
Sbjct: 502 TVTQKVEEHE---ETFEEKLVSTKKVEKVTSHAIVK 534
Score = 92.8 bits (229), Expect = 1e-18
Identities = 121/513 (23%), Positives = 213/513 (41%), Gaps = 73/513 (14%)
Query: 138 LRKKEIHKDKTEKQEKPERKI--QTKVTHKEKEKGK------EKVREKEKPEKKATHKEK 189
++K ++ K + Q K +I +TKV ++ E + E++ K EKK +EK
Sbjct: 60 IQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEK 119
Query: 190 IEKKEKPETKTLAKEQKKAKTAE--KSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKP 247
E+ E E + AK+ TA K EE K+E +G ++E+ + AK + ++ S+
Sbjct: 120 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 179
Query: 248 KEKEDKE-----------KAAVSKHEQKDQYAFCRYMIDIFVHGDL-------KPGQSPA 289
+ +KE +A + E K++ ++ +L KP ++ +
Sbjct: 180 EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKS 239
Query: 290 IPPPLPTEQASR-PTPASPALEEKEG--EKKKAEKKVTSETKKKEKEDIKKKSEKETAID 346
P P E+ + P P SP E+ + K E+K S K E+ K ++ ++
Sbjct: 240 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE 299
Query: 347 VEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEP 406
+ K P S ++ K +K+E++++ K+ K +VE+ + K ++ EK +
Sbjct: 300 EKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEK--KK 357
Query: 407 AKSPKKEHSVPS----DKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEK 462
A+SP KE +V K VK E+ +E G K ++QE KEK
Sbjct: 358 AESPVKEEAVAEVVTITKSVKVHLEKETKEEG-----------------KPLQQEKEKEK 400
Query: 463 SGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKP 522
+G ++ G ++ S KE + E + +E K K G++EEK
Sbjct: 401 AGGEGGSEEE-----GSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKG---SGREEEKG 452
Query: 523 EPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQ-----VKAVTIEKTAKPK 577
+ PA +K ++ V KTV EK+ + K +T T K
Sbjct: 453 VVTNGLDLSPADEKKGGDKSEEKVVVTKTV------EKITSEGGDGATKYITKSVTVTQK 506
Query: 578 PTKKAEHREREPPSIKTDKPKPTPKGTSEVTES 610
+ E E + S K + + EVT+S
Sbjct: 507 VEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQS 539
Score = 89.7 bits (221), Expect = 8e-18
Identities = 103/411 (25%), Positives = 180/411 (43%), Gaps = 25/411 (6%)
Query: 289 AIPPPLPTEQASRPTPASPALEEKEGEKKKAEKK----VTSETK----KKEKEDIKKKSE 340
+I PL T + + + E K K + K + ETK K E E+
Sbjct: 42 SITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAIT 101
Query: 341 KETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKK 400
+E A+ +++++ A E ++ + AAKK K + + K+ E E+ + + QE++
Sbjct: 102 EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKE-EEGEKEEEEGQEEE 160
Query: 401 EKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIK---KAVPGKKEEKTTKTVEQE 457
E+ E AKS + E S+K+ ++ E ++E G + + K+E+K + E+
Sbjct: 161 EEEDEGAKSDQAEEG-GSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEV 219
Query: 458 IRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGK 517
KE+ + + K E K K P K K P K + + GK PK P +
Sbjct: 220 ATKEELVADAKVEK-PEKAKSPVPKSPVEEKGKSPVPK--SPVEEKGKSPVPKSPVEEKG 276
Query: 518 KEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPK 577
K P+ ++++ K +S+ K P+ V K + +V K + EK K
Sbjct: 277 KSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEA 336
Query: 578 P-TKKAEHREREPPSIKTDKPKPTP---KGTSEVTESGKKKTEISEKESKEKADMKHLRE 633
P +K E +E +P + K +P + +EV K EKE+KE+ K L++
Sbjct: 337 PKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEG--KPLQQ 394
Query: 634 EKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDV-SPTKQK 683
EK + ++K A+ S+ ED+ + + EG E+V TK+K
Sbjct: 395 EKEKEKAGGEGGSEEEGSDKGAKGSRK-EDIAVNGEV-EGKEEVEQETKEK 443
Score = 79.7 bits (195), Expect = 9e-15
Identities = 89/369 (24%), Positives = 153/369 (41%), Gaps = 65/369 (17%)
Query: 323 VTSETKKKEKEDIKKKSEKETAIDV--EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDS 380
++S+ +K + E K K + + ++ E K + SE ++ I + A E+K+++
Sbjct: 56 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEA 115
Query: 381 KKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKK 440
+ K+ E+P E +E+ V KSP VKA KEE G K+
Sbjct: 116 AEEKE----EEP-----EAEEEEVAAKKSP-----------VKATAPEVKEEEGE---KE 152
Query: 441 AVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKM 500
G++EE+ + + E+ G +KE + +E + A + +E E K+++K+
Sbjct: 153 EEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKV 212
Query: 501 SKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEK 560
+ +EV K + K EKPE K + V EEK
Sbjct: 213 EEKSEEVATKEELVADAKVEKPE-----------------------KAKSPVPKSPVEEK 249
Query: 561 VLKQVKAVTIEKTAK-PKPTKKAEHREREP-PSIKTDKPKPTPKGTSEVTESGKK---KT 615
V +E+ K P P E + + P P ++ +P S V E K K+
Sbjct: 250 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKS 309
Query: 616 EISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTE 675
+ E +SK + +EE+ KE+ K EK + + +DVP KKA+
Sbjct: 310 PVEEAKSKAEVGKGEQKEEEEKEVKEA------PKEEKVEKKEEKPKDVPEKKKAE---- 359
Query: 676 DVSPTKQKS 684
SP K+++
Sbjct: 360 --SPVKEEA 366
Score = 41.6 bits (96), Expect = 0.003
Identities = 50/196 (25%), Positives = 84/196 (42%), Gaps = 45/196 (22%)
Query: 531 KPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVK-------------AVTIEKTAKPK 577
+P I+ +I K + P+ V H K E+++++ K A+T E K
Sbjct: 51 RPPITISSKIQKPKVEAPKLKVQH-KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMK 109
Query: 578 PTKK--AEHREREPPSIKTD---KPKPTPKGTSEVTES-GKKKTEISEKESKEK------ 625
KK AE +E EP + + + K P EV E G+K+ E ++E +E+
Sbjct: 110 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKS 169
Query: 626 --ADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVS----- 678
A+ +E S ++E Q T+AE ++ E+ KK +E +E+V+
Sbjct: 170 DQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEE----KKVEEKSEEVATKEEL 225
Query: 679 --------PTKQKSPI 686
P K KSP+
Sbjct: 226 VADAKVEKPEKAKSPV 241
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 101 bits (252), Expect = 2e-21
Identities = 125/474 (26%), Positives = 210/474 (44%), Gaps = 82/474 (17%)
Query: 90 KLVRDAMEET------TDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEI 143
K V + +EET ++ ++ ++ S EE + E+ + +EP ++E+
Sbjct: 451 KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE----EEPEAEEEEV 506
Query: 144 HKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIE------------ 191
K+ P + +V +E EK +E+ +E+E+ E + ++ E
Sbjct: 507 AAKKS-----PVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEK 561
Query: 192 ---KKEKPETKTLAK-EQKKAKTAEKSEEK-----TKKEV----KGGKQEKVKQTAAK-- 236
++E+ ET+ A+ E+ +AK +K EEK TK+E+ K K EK K K
Sbjct: 562 EEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSP 621
Query: 237 VKEVQKTPSKPKEKEDKEKAAVSKH--EQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPL 294
V+E K+P E+K K+ V K E+K + + ++ + G+SP P+
Sbjct: 622 VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE-------EKGKSPVSKSPV 674
Query: 295 PTEQASRPTPASPALEEK------EGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVE 348
E+A P P SP E K +GE+K+ E+K E K+EK ++KK EK + +
Sbjct: 675 -EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEK--VEKKEEKPKDVPEK 731
Query: 349 KKEPGKASETKQGTVKIAAQAAAKKDEK--KEDSKKTKKPAEVEQPKGKKQEKKEKHVEP 406
KK E V ++ EK KE+ K ++ E E+ G+ ++E +
Sbjct: 732 KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKG 791
Query: 407 AKSPKKEHSVPS---------DKQVKAKTERAKEEIGAV--------SIKKAVPGKKEEK 449
AK +KE + +++ K K +EE G V + +K K EEK
Sbjct: 792 AKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEK 851
Query: 450 --TTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMS 501
TKTVE+ + G T I K + K E+ + +EK TKK EK++
Sbjct: 852 VVVTKTVEKITSEGGDGATKYITK-SVTVTQKVEEHEETFEEKLVSTKKVEKVT 904
Score = 95.9 bits (237), Expect = 1e-19
Identities = 127/545 (23%), Positives = 242/545 (44%), Gaps = 52/545 (9%)
Query: 132 EIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHK---- 187
++ E + KE + E+ + R++Q+K E +G ++ E++ + + H
Sbjct: 298 KLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLS 357
Query: 188 ------EKIEKKEKPETKTLAKEQKK------AKTAEKSEEKTKKEVKGGKQEKVKQTAA 235
+++E + + +A+ ++ K A E +++ G++ + A
Sbjct: 358 SYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAG 417
Query: 236 KVKEVQKTPSKPKEKEDK-EKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPL 294
+ T P K +K V + K Q+ F +I+ D K A+
Sbjct: 418 SITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAIT 477
Query: 295 PTEQASRPTPASPALEEKEGEKKKAEKKVTSE------TKKKEKEDIKKKSEKETAIDVE 348
S A EEKE E + E++V ++ T + KE+ +K E+E + E
Sbjct: 478 EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE 537
Query: 349 KKEPG-KASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEK-KEKHVEP 406
+++ G K+ + ++G + + +++K+E +++ +T+ AE E+ + K+++K +EK E
Sbjct: 538 EEDEGAKSDQAEEGGSE--KEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEV 595
Query: 407 AKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKT 466
A + +K KAK+ K + K VP E+ K+ + E+ GK
Sbjct: 596 ATKEELVADAKVEKPEKAKSPVPKSPVEEKG-KSPVPKSPVEEKGKSPVPKSPVEEKGK- 653
Query: 467 SSILKDKEPIKGKE--EKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEP 524
S + K KGK K P K K P K + +K+ EV +G+++E+ E
Sbjct: 654 SPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVG------KGEQKEEEEK 707
Query: 525 QIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEH 584
++K+ K EK + +D+ PEK + +E+ + +V VTI K+ K K+ +
Sbjct: 708 EVKEAPKEEKVEKKEEKPKDV--PEKKKAESPVKEEAVAEV--VTITKSVKVHLEKETK- 762
Query: 585 REREPPSIKTDKPKPTPKGTSEVTES-----GKKKTEIS---EKESKEKADMKHLREEKV 636
E +P + +K K +G SE S G +K +I+ E E KE+ + + +EK
Sbjct: 763 EEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQE--TKEKG 820
Query: 637 STRKE 641
S R+E
Sbjct: 821 SGREE 825
Score = 94.4 bits (233), Expect = 3e-19
Identities = 136/516 (26%), Positives = 220/516 (42%), Gaps = 50/516 (9%)
Query: 153 KPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPE-----TKTLA---KE 204
+P I +K+ + E K KV+ K E K + EK E E T+ LA KE
Sbjct: 427 RPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKE 486
Query: 205 QKKAKTAEKSEE-KTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPK-EKEDKEKAAVSKHE 262
+KK EK EE + ++E K+ VK TA +VKE + + + ++E++E+ +K +
Sbjct: 487 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSD 546
Query: 263 QKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEG--EKKKAE 320
Q ++ G K G S EQ T A EE E EKK E
Sbjct: 547 QAEE------------GGSEKEGSSEKEEG----EQEEGETEAEAEGEEAEAKEEKKVEE 590
Query: 321 KKVTSETKKKEKEDIKKKSEKETAIDVEK---KEPGKASETKQGTVKIAAQAAAKKDEKK 377
K TK++ D K + ++ V K +E GK S + V+ ++ K +
Sbjct: 591 KSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGK-SPVPKSPVEEKGKSPVPKSPVE 649
Query: 378 EDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVS 437
E K + VE+ KGK K E AKSP + V ++ K+K E K E
Sbjct: 650 EKGKSPVPKSPVEE-KGKSPVSKSPVEEKAKSPVPKSPV---EEAKSKAEVGKGEQKEEE 705
Query: 438 IKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLK-EKEPETKK 496
K+ KEEK K ++E K+ K + KE + + S+K E ETK+
Sbjct: 706 EKEVKEAPKEEKVEK--KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKE 763
Query: 497 DEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIH-KQDIVKPEKTVSHG 555
+ K + KE K K G +EE + K K I+ ++ K+++ + K G
Sbjct: 764 EGKPLQQEKE-KEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSG 822
Query: 556 KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKT 615
+ EEK + + + + K K+E + +++ K T +G T+ K
Sbjct: 823 REEEKGVV-TNGLDLSPADEKKGGDKSEEKVVVTKTVE----KITSEGGDGATKYITKSV 877
Query: 616 EISEKESKEKADMKHLREEKVSTRK-ESLQLHNVTK 650
+++K + + + E+ VST+K E + H + K
Sbjct: 878 TVTQKVEEHE---ETFEEKLVSTKKVEKVTSHAIVK 910
Score = 92.4 bits (228), Expect = 1e-18
Identities = 125/556 (22%), Positives = 237/556 (42%), Gaps = 51/556 (9%)
Query: 142 EIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKE-KPETKT 200
E H D+ Q + K + + E+ KE +R + E+ A ++ +++ K + E+
Sbjct: 278 ESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAK--EEIAEYRRQLQSKSIELESVR 335
Query: 201 LAKEQKKAKTAEKSE-------------EKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKP 247
KE + + ++ E ++ + E++G K E + ++E Q +
Sbjct: 336 GTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARH----LREYQDLLNV- 390
Query: 248 KEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASP 307
K D E AA K + ++ F + G + PP + + +P +P
Sbjct: 391 KMALDIEIAAYRKLLEGEETRFSTFA------GSITGPLYTHRPPITISSKIQKPKVEAP 444
Query: 308 ALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAA 367
L+ + ++ ++ E +K E E+ +E A+ +++++ A E ++
Sbjct: 445 KLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEE 504
Query: 368 QAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTE 427
+ AAKK K + + K+ E E+ + + QE++E+ E AKS + E S+K+ ++ E
Sbjct: 505 EVAAKKSPVKATAPEVKEE-EGEKEEEEGQEEEEEEDEGAKSDQAEEG-GSEKEGSSEKE 562
Query: 428 RAKEEIGAVSIK---KAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVP 484
++E G + + K+E+K + E+ KE+ + + K E K K P
Sbjct: 563 EGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP-EKAKSPVPKSP 621
Query: 485 ASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQD 544
K K P K + + GK PK P + K P+ ++++ K +S+ K
Sbjct: 622 VEEKGKSPVPKSP--VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAK 679
Query: 545 IVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGT 604
P+ V K + +V K + EK K P K E E+ K +KPK P+
Sbjct: 680 SPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAP--KEEKVEK-----KEEKPKDVPE-- 730
Query: 605 SEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDV 664
+ ES K+ ++E + K+ HL +E T++E L + EK E+
Sbjct: 731 KKKAESPVKEEAVAEVVTITKSVKVHLEKE---TKEEGKPLQQEKEKEKAGGEGGSEEE- 786
Query: 665 PASKKAKEGT--EDVS 678
S K +G+ ED++
Sbjct: 787 -GSDKGAKGSRKEDIA 801
Score = 46.2 bits (108), Expect = 1e-04
Identities = 95/437 (21%), Positives = 177/437 (40%), Gaps = 88/437 (20%)
Query: 309 LEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQ 368
+EE K + +KKV S + E ++ E+E A + + + + ++ +K
Sbjct: 210 IEEASLVKVELDKKVQS--LQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDIS 267
Query: 369 AAAKKDEKKEDSKKTKKPAEVEQ----PKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKA 424
A K+ + +S + + E+ K E E++ E +S K+E +
Sbjct: 268 TALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIA--------- 318
Query: 425 KTERAKEEIGAVSIK-KAVPGKKE--EKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEE 481
+ ++ + SI+ ++V G KE E+ +E+ + S +I + + ++G +
Sbjct: 319 ---EYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKW 375
Query: 482 KVPASLKEKEP-------------------ETKKDEKMSKAGKEVKP----KPPQLQGKK 518
++ L+E + E ++ + AG P +PP K
Sbjct: 376 EMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSK 435
Query: 519 EEKPEPQIKKEAKPAISEKVQIHK--QDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKP 576
+KP+ + K KVQ HK ++I++ K E+ L A+T E
Sbjct: 436 IQKPKVEAPKL-------KVQ-HKFVEEIIEETKVEDEKSEMEEALT---AITEELAVSM 484
Query: 577 KPTKK--AEHREREPPSIKTD---KPKPTPKGTSEVTES-GKKKTEISEKESKEK----- 625
K KK AE +E EP + + + K P EV E G+K+ E ++E +E+
Sbjct: 485 KEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAK 544
Query: 626 ---ADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVS---- 678
A+ +E S ++E Q T+AE ++ E+ KK +E +E+V+
Sbjct: 545 SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEE----KKVEEKSEEVATKEE 600
Query: 679 ---------PTKQKSPI 686
P K KSP+
Sbjct: 601 LVADAKVEKPEKAKSPV 617
Score = 45.4 bits (106), Expect = 2e-04
Identities = 52/200 (26%), Positives = 87/200 (43%), Gaps = 21/200 (10%)
Query: 493 ETKKDEKMSKAGKEVKPKPPQLQ-GKKEEKPEPQIKKEAKPAISEKVQIHKQDIVK---P 548
ETK +++ S+ + + +L KEEK E +KE +P E+ K+ VK P
Sbjct: 459 ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAP 518
Query: 549 EKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVT 608
E G+ EE+ ++ + E+ + + +AE E + +G +E
Sbjct: 519 EVKEEEGEKEEEEGQEEE----EEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAE 574
Query: 609 ESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASK 668
G++ EK+ +EK+ E+V+T++E L K EKP + V P +
Sbjct: 575 AEGEEAEAKEEKKVEEKS-------EEVATKEE---LVADAKVEKPEKAKSPVPKSPVEE 624
Query: 669 KAKEGTEDVSPT--KQKSPI 686
K K SP K KSP+
Sbjct: 625 KGKSPVPK-SPVEEKGKSPV 643
Score = 32.0 bits (71), Expect = 2.1
Identities = 33/139 (23%), Positives = 66/139 (47%), Gaps = 18/139 (12%)
Query: 120 EDDDGDEDTDKGEIDEPPLRKKEIHKD-KTEKQEKPERKIQTKVTHKEKEKG-------- 170
E +E +DKG RK++I + + E +E+ E++ + K + +E+EKG
Sbjct: 780 EGGSEEEGSDKGAKGS---RKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDL 836
Query: 171 --KEKVREKEKPEKKATHKEKIEKKEKP----ETKTLAKEQKKAKTAEKSEEKTKKEVKG 224
++ + +K E+K + +EK TK + K + E+ EE ++++
Sbjct: 837 SPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVS 896
Query: 225 GKQEKVKQTAAKVKEVQKT 243
K+ + + A VKEV ++
Sbjct: 897 TKKVEKVTSHAIVKEVTQS 915
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 100 bits (249), Expect = 5e-21
Identities = 144/602 (23%), Positives = 256/602 (42%), Gaps = 79/602 (13%)
Query: 117 EDEEDDDGDEDTDKGE----IDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKE 172
+ E + ++ TDKGE +E RKKE K+KTEK+ +K + K++++ KE
Sbjct: 308 QQESSEQKNKSTDKGEKKPDSNEKGERKKE-KKEKTEKKFDHSKKSEDTQKVKDEKQAKE 366
Query: 173 KVREKEK-PEKKATHKEKIEKKEKPETKTLAKE--------QKKAKTAEKS--EEKTKKE 221
K E K P +K ++K K + K + + + T++ S EE T++E
Sbjct: 367 KEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEE 426
Query: 222 V---KGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFV 278
V ++ ++ + + KT ++ + + + +V Y + +Y D
Sbjct: 427 VVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSD--S 484
Query: 279 HGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEK------ 332
+L Q E+ R LEEK K+KAEK +S+TK + +
Sbjct: 485 DDELTVEQRRQSIAKEKEERLLRRQINREKLEEK--RKQKAEKTKSSKTKGQGRSSVDLE 542
Query: 333 EDIKKKSEKETAIDVEKKEPGKASETKQGTVK-------IAAQAAAKKDEKKEDSKKTKK 385
E K E + A E + K E K K + + KK + +EDSK+T K
Sbjct: 543 ESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLK 602
Query: 386 PAEVEQPKGKKQEKKEKHVEPAKSPKKE--------HSVPSDKQVKAKTERAKEEIGAVS 437
+E + + K+ KHV P K H V +K ++K ER E S
Sbjct: 603 TSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKN-ESKLER--EHKRRTS 659
Query: 438 IKKAVPGKKEEKTTKTVEQEIRK-----EKSGKTSSILKDKEPIKGKEEKVP--ASLKEK 490
+ G +EE T+ V++++ + E+ K S LK+++ +K + + P SL +K
Sbjct: 660 TPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKK 719
Query: 491 EPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEK 550
E ++ K+ K +E P +L K + K + K ++ ++H EK
Sbjct: 720 EVKSSKE----KPEREKTPSEDKLSVKHKYKGDCMHK------TGDETELHSS-----EK 764
Query: 551 TVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTES 610
+ K EE + KQ + + ++ K +K++HR S+ KP + + E+
Sbjct: 765 GL---KVEENIQKQSQQTKL--SSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDEN 819
Query: 611 GKKKTEISEKE---SKEKADMKHLREEKVSTRKESL--QLHNVTKAEKPARVSKDVEDVP 665
+K+ E+ K KA+ K R +K+SL + H +T + S+D D+
Sbjct: 820 VRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMD 879
Query: 666 AS 667
++
Sbjct: 880 ST 881
Score = 77.4 bits (189), Expect = 4e-14
Identities = 97/447 (21%), Positives = 168/447 (37%), Gaps = 70/447 (15%)
Query: 296 TEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEK--EDIKKKSEKETAIDVEKKEPG 353
+E+AS+ P+ P + +++ +E E + E ++ + E D+ P
Sbjct: 230 SERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDL----PC 285
Query: 354 KASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKK- 412
E K T + KD ++E S++ K + + K EK E+ E + +K
Sbjct: 286 PVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKK 345
Query: 413 -EHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQE------IRKEKSGK 465
+HS S+ K K E+ +E S+K +P +K KTVE I + G
Sbjct: 346 FDHSKKSEDTQKVKDEKQAKEKEVESLK--LPSEKNSNKAKTVEGTKEDFSLIDSDVDGL 403
Query: 466 T------------SSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQ 513
T SS +D E EE V + E+ T DE+ +K K
Sbjct: 404 TDITVSSVHTSDLSSFEEDTE-----EEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDS 458
Query: 514 LQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEK---TVSHGKPEEKVLKQVKAVTI 570
+GK + + K P + K D + E+ +++ K E + +Q+ +
Sbjct: 459 SEGKTKSVRHAYVHK---PYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKL 515
Query: 571 EKTAKPKPTKKAEHRER---------EPPSIKTDKPKPT--------------------- 600
E+ K K K + + E S K+ +PK
Sbjct: 516 EEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKK 575
Query: 601 -PKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSK 659
K + V E+ KKK + E + +H +EK+S+ KE +H ++ KPAR
Sbjct: 576 RKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLS 635
Query: 660 DVEDVPASKKAKEGTEDVSPTKQKSPI 686
+ V K + E + +P+
Sbjct: 636 ESLHVVDENKNESKLEREHKRRTSTPV 662
Score = 74.3 bits (181), Expect = 4e-13
Identities = 109/566 (19%), Positives = 211/566 (37%), Gaps = 99/566 (17%)
Query: 129 DKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKE 188
D ++E +K++ +D E + E + K++ ++ K E KP ++ +
Sbjct: 579 DSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESL 638
Query: 189 KIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPK 248
+ + K E+K L +E K+ + E ++E VK+ + + + P K K
Sbjct: 639 HVVDENKNESK-LEREHKRRTSTPVIMEGVQEET---DTRDVKRQVERSEICTEEPQKQK 694
Query: 249 EKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPA 308
E KH +KD ++P + L E S +
Sbjct: 695 STLKNE-----KHLKKDD------------------SETPHLKSLLKKEVKS-------S 724
Query: 309 LEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQ 368
E+ E EK +E K++ K K K D K+ ET E K + ++ K + Q
Sbjct: 725 KEKPEREKTPSEDKLS--VKHKYKGDCMHKTGDET----ELHSSEKGLKVEENIQKQSQQ 778
Query: 369 AAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTER 428
D+K E K + E+K + P E+ + +D+ V+ + +
Sbjct: 779 TKLSSDDKTERKSK------------HRNERKLSVLGKDGKPVSEYIIKTDENVRKENNK 826
Query: 429 AKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSG-KTSSILKDKEPIKGKEEKVPASL 487
+ + A K E K+ ++ + +I+K+ G K I + E+K
Sbjct: 827 KERRLSAEKT------KAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDS 880
Query: 488 KEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVK 547
+ K +E + K K+ K + EK +V
Sbjct: 881 TNMDSNLKPEEVVHKE-----------------------KRRTKSLLEEK-------LVL 910
Query: 548 PEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTP---KGT 604
K+ + GK + V +++ ++ PKP K+ E + + K + P G
Sbjct: 911 KSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGV 970
Query: 605 SEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESL------QLHNVTKAEKPARVS 658
V E+ ++K+S +A + L +EK + K+S +L + K+ S
Sbjct: 971 EPVLETASSSAHSTQKDSSHRAKLP-LAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSS 1029
Query: 659 KDVEDVPASKKAKEGTEDVSPTKQKS 684
KD++ +K + ++V + +K+
Sbjct: 1030 KDIKKKDENKSDDKDGKEVDSSHEKA 1055
Score = 57.8 bits (138), Expect = 4e-08
Identities = 83/411 (20%), Positives = 166/411 (40%), Gaps = 61/411 (14%)
Query: 153 KPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAE 212
K K++ V +E++ G+ + K + +++++ ++L E +T E
Sbjct: 2667 KANLKMEAYVPSEEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRTNE 2726
Query: 213 K--SEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFC 270
+ SE K E+ G+++ + + E PKE E++E+ + K ++K Y
Sbjct: 2727 EIHSESYNKGEISSGRKDNAEAISGHSVEAD-----PKEVEEEERH-MPKRKRKQHYLSS 2780
Query: 271 RYMID-----IFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEG--------EKK 317
D + + Q P P E+ SR P + EK
Sbjct: 2781 EDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKD 2840
Query: 318 KAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKA--------------SETKQGTV 363
+ T+ K ++ +D KS++E + K++ G+ S+T G V
Sbjct: 2841 EYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIV 2900
Query: 364 KIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAK----SPKKEHSVPSD 419
+ ++ K + + + K+ A +++ + +EK V + PK+ +V D
Sbjct: 2901 TVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDD 2960
Query: 420 KQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGK 479
+ ++ ER +++ S+ V KKE+++ + E+E E SG T+ E + K
Sbjct: 2961 AE-SSEPERKRQK----SVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSK 3015
Query: 480 EEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKK--EEKPEPQIKK 528
+ P S+K K +EV P + +G++ EE P + K+
Sbjct: 3016 TQLSP-SIKRK--------------REVSPPGARTRGQQRVEEAPVKKAKR 3051
Score = 54.7 bits (130), Expect = 3e-07
Identities = 66/308 (21%), Positives = 127/308 (41%), Gaps = 43/308 (13%)
Query: 114 ISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEK----QEKPERKIQTKVTHKEKEK 169
+SSEDE DD+ D + E + + E H K E +E P+ +T T +
Sbjct: 2778 LSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVME 2837
Query: 170 GKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQE- 228
K++ E +K + K + E + + ++K+ + + E T K K +
Sbjct: 2838 EKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDT 2897
Query: 229 ---KVKQTAAKVK-EVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKP 284
V+Q+ + K +V +T KE + ++ ++S + +++ V +
Sbjct: 2898 GIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEK----------IVTSVRRR 2947
Query: 285 GQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETA 344
G+ P R S E E E+K+ +K V+ + K++++ ++ E+E
Sbjct: 2948 GRKP-----------KRSLTVSDDAESSEPERKR-QKSVSDPVEDKKEQESDEEEEEE-- 2993
Query: 345 IDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHV 404
E+ EP A T + T + AQ + K + S K+ EV P + + ++
Sbjct: 2994 ---EEDEPSGA--TTRSTTRSEAQRS-----KTQLSPSIKRKREVSPPGARTRGQQRVEE 3043
Query: 405 EPAKSPKK 412
P K K+
Sbjct: 3044 APVKKAKR 3051
Score = 39.7 bits (91), Expect = 0.010
Identities = 69/370 (18%), Positives = 139/370 (37%), Gaps = 71/370 (19%)
Query: 307 PALEEKEGE-----------------KKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEK 349
P+ EEK GE + + E + +E+ E + E I E
Sbjct: 2677 PSEEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRTNEE----IHSES 2732
Query: 350 KEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKS 409
G+ S ++ + + + + D K+ + ++ P + +KQ EP +
Sbjct: 2733 YNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPK-----RKRKQHYLSSEDEPDDN 2787
Query: 410 PKKEHS-VPSDKQVKAKTER--AKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKT 466
P S + + ++ +TE KEE + + TT V +E + S +T
Sbjct: 2788 PDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSET 2847
Query: 467 SSIL---KDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPE 523
+ D + IK +EE P +K K +K P L+ K + K +
Sbjct: 2848 TGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRK-----------YPVETTLKMKDDSKTD 2896
Query: 524 PQIKKEAKPAISEKVQI------HKQDIVKPEKTVSHGKPEEKVLKQVK--------AVT 569
I + S K+++ +K+ E+++S+ EEK++ V+ ++T
Sbjct: 2897 TGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLT 2956
Query: 570 IEKTAK--------------PKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKT 615
+ A+ P KK + + E + D+P ++ +E+ + KT
Sbjct: 2957 VSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKT 3016
Query: 616 EISEKESKEK 625
++S +++
Sbjct: 3017 QLSPSIKRKR 3026
Score = 33.5 bits (75), Expect = 0.72
Identities = 109/506 (21%), Positives = 181/506 (35%), Gaps = 75/506 (14%)
Query: 200 TLAKEQKKAKTAEKSEEKT-KKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAV 258
T A + EK E+ T + GG + + + +V E + + P EKED++
Sbjct: 1980 TSAASDQSDSQLEKVEDTTISTGLVGGSYDVL--VSGEVPECEVAHTSPSEKEDEDIITS 2037
Query: 259 SKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEG---- 314
++E+ D DI L G++ + T + TP A+ + EG
Sbjct: 2038 VENEECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSD 2097
Query: 315 -----EKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQG-------- 361
E + + T E + + + TA E+K+ T G
Sbjct: 2098 ALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPIS 2157
Query: 362 ---TVKIA--AQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSV 416
T+K A Q A E++ A+ E P + E P S KE
Sbjct: 2158 SATTIKCAESLQPVAAAVEERATGPVLISTADFEGPMPSAPPEAE---SPLASTSKEE-- 2212
Query: 417 PSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSG--KTSSILKDKE 474
D+ T A+E +VS V + E + TV +E K+ SG TSS+ +
Sbjct: 2213 -KDECALISTSIAEECEASVS---GVVVESENERAGTVMEE--KDGSGIISTSSVEDCEG 2266
Query: 475 PIKG---KEEKVPA-SLKEKEPETKKDEKMSKAGKEVKPKPPQLQG-------KKEEKPE 523
P+ +EE P+ + E+ +T + G E LQ + E+ +
Sbjct: 2267 PVSSAVPQEEGDPSVTPAEEMGDTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLSD 2326
Query: 524 PQI----KKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPT 579
I E P IS + H+++ + + +G + A + K P P+
Sbjct: 2327 AAIISTSTAECMP-ISASIDRHEENQLTADNPEGNG--------DLSATEVSKHKVPMPS 2377
Query: 580 KKAEHREREPPSIKTDK-PKPTPKGTSEVTESGKK-----------KTEISEKESKEKAD 627
AE+ R P ++ K P P ++E +G +EKE K +
Sbjct: 2378 LIAENNCRCPGPVRGGKEPGPVLAVSTEEGHNGPSVHKPSAGQGHPSAVCAEKEEKHGKE 2437
Query: 628 MKHLREEKVSTRKESLQLHNVTKAEK 653
+ +KES LH + EK
Sbjct: 2438 CPEIGPFAGRGQKES-TLHLINAEEK 2462
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 98.6 bits (244), Expect = 2e-20
Identities = 147/617 (23%), Positives = 246/617 (39%), Gaps = 105/617 (17%)
Query: 134 DEPPLRKKEIHKDKTEKQEKPERKIQTK----VTHKEKEKGKEKVREKEKPEKKATHKEK 189
DE L+ K+I + E +QTK V+ + K+KGK K + K + + K + K
Sbjct: 407 DEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELK 466
Query: 190 IEKKEKPETKTLAKEQKKAKTAEKSEEKTKKE-------------------VKGGKQEKV 230
EK+ K T+ T EKT++E + GK K
Sbjct: 467 QEKEGKENTRIT---NLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPK- 522
Query: 231 KQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAI 290
+ + E Q TP K ++ K + E Q RY + P +S ++
Sbjct: 523 --HSCGLSEKQSTPLK--QEHTKTCLSPGSSEMSLQPDLVRYDN---TESEFLP-ESSSV 574
Query: 291 PPPLPTEQAS-----------------RPTPASPALEEKEGEKKKAEK--KVTSETKKKE 331
E++ + SP E + KK +K K + K K
Sbjct: 575 KSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKH 634
Query: 332 KEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQ 391
KE K+K +KE + EK + +++ Q +V+ + + K ++++ E E
Sbjct: 635 KEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHES 694
Query: 392 PKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTT 451
+K+ K EK+++ KS K++H V ++ K + ++ K+E ++ + KEE+
Sbjct: 695 LTLEKKSKLEKNIKDDKSTKEKH-VSKERNFKEERDKIKKESEKSFREEKIKDLKEER-- 751
Query: 452 KTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKP 511
+ I +K + +S+ + EE + L EKE + +K EK K KE K
Sbjct: 752 ----ENIPTDKDSEFTSL-----GMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKR 802
Query: 512 PQLQGKKEEKPEPQ-IKKEAKPAISEKVQIHKQD-------IVKPEKTVSH--GKPEEKV 561
Q++ K EK E + +KE K K + K D I + +K SH K ++
Sbjct: 803 SQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEG 862
Query: 562 LKQVKAVTIEKT--------------AKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEV 607
K I+KT K KP K+ E + + K K +
Sbjct: 863 EKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSK 922
Query: 608 TESGKKKTEISEKESKEKA---------DMKHLREEKVSTRKESLQLHNVTKAEKPARVS 658
+E GK K + E + KEK+ + KH++EEK K S+ N + EKP +
Sbjct: 923 SEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEK----KSSIVDGNKAQHEKPLSLK 978
Query: 659 KDVEDVPASKKAKEGTE 675
+ +D P K +G E
Sbjct: 979 EKTKDEPL--KTPDGKE 993
Score = 94.4 bits (233), Expect = 3e-19
Identities = 144/618 (23%), Positives = 253/618 (40%), Gaps = 118/618 (19%)
Query: 130 KGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVR---EKEKPEKKATH 186
K E P + K +K+ K +K K+ HKE+EK K K EKEK + K +
Sbjct: 602 KDEDHSPTFENSDCTLKKMDKEGKTLKK--HKLKHKEREKEKHKKEIEGEKEKYKTKDSA 659
Query: 187 KE-----------------KIEKKE------KPETKTLAKEQKKAKTAEKSEEKTKKEVK 223
KE K ++ E + E+ TL K+ K K + ++K+ KE
Sbjct: 660 KELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIK--DDKSTKEKH 717
Query: 224 GGKQEKVKQTAAKVKEVQKTPSKPKE----KEDKEKAAVSKHEQKDQYAFCRYMIDIFVH 279
K+ K+ K+K+ + + ++ KE++E K + I +H
Sbjct: 718 VSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLH 777
Query: 280 GDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAE----KKVTSETKKKEKEDI 335
+ + E+ + S EK + K+ + ++ T E +KK K +
Sbjct: 778 ---------LVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEH 828
Query: 336 KKKSEK----ETAIDVEKKEPGKASET----KQGTVKIAAQAAAKKDEKKEDSKKTKKPA 387
K + +K E +++K+ + T K+G A K D++++ +K +
Sbjct: 829 KSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKH 888
Query: 388 EVEQPKGKKQ--EKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGK 445
+ E+P+ ++ E KEKH+ K+ + SD +K+E+ K + + K +
Sbjct: 889 DKEKPEKERHLAESKEKHLMEKKNKQ------SDNSEYSKSEKGKNKEKDRELDKKEKSR 942
Query: 446 KEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGK 505
+E T + I++EK SSI+ K + EK P SLKEK TK + + GK
Sbjct: 943 DKESINITNSKHIQEEKK---SSIVDGN---KAQHEK-PLSLKEK---TKDEPLKTPDGK 992
Query: 506 EVKPKPPQLQGKKE--------------------EKPEPQIKKEAKPAISEKVQIHKQDI 545
E K + KE +KP+P+ +K ++ ++ D+
Sbjct: 993 EKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDL 1052
Query: 546 VKP--EKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIK---TDKPK-- 598
++ E+ +S LK ++ K K K +K + R R ++ DK K
Sbjct: 1053 MQTSFERMLS--------LKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTK 1104
Query: 599 --PTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPAR 656
PT E+T S K +E+++ +KEK ++ VS R +S+ NV K +
Sbjct: 1105 HTPTESKNKELTRS--KSSEVTDAYTKEKQP-----KDAVSNRSQSVDTKNVMTLGKSSF 1157
Query: 657 VS-KDVEDVPASKKAKEG 673
VS + P S+ K G
Sbjct: 1158 VSDNSLNRSPRSENEKPG 1175
Score = 92.0 bits (227), Expect = 2e-18
Identities = 141/616 (22%), Positives = 243/616 (39%), Gaps = 76/616 (12%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVRE 176
E E DD DE+ +K D LRK++ +++ E ++ Q K + + K K
Sbjct: 337 EYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSK----- 391
Query: 177 KEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKE-VKGGKQEKVKQTAA 235
K+KP + + +E + K ++ S+ +TKKE V G+ ++ +
Sbjct: 392 KQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKR 451
Query: 236 KVKEVQKTPSK---PKEKEDKEKAAVS----------KHEQKDQYAFCRYMI---DIFVH 279
K+K K +EKE KE ++ + +++ F + D +H
Sbjct: 452 KLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLH 511
Query: 280 -GDLKPGQSP------AIPPPLPTEQASRPTPASPALEEK-------EGEKKKAEKKVTS 325
+ G+SP + P +Q T SP E + ++E S
Sbjct: 512 LFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPES 571
Query: 326 ETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKK 385
+ K K K K +K+ ++ +K K + + KK +K + K KK
Sbjct: 572 SSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDK--EGKTLKK 629
Query: 386 PAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGK 445
+ + K++ KKE E K K+ + + V+ E KE +
Sbjct: 630 HKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENF-------FKSDE 682
Query: 446 KEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGK 505
E+ + + EK K +KD + K K + KE+ + KK+ + S +
Sbjct: 683 TEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREE 742
Query: 506 EVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIH----KQDIVKPEKTV--SHGKPE- 558
++K + + +K + + AI E + +H + DI K EK + S KPE
Sbjct: 743 KIKDLKEERENIPTDK-DSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEK 801
Query: 559 -----EKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKK 613
EK +++++ T EK K K K+E +++ S DK K K S TE K
Sbjct: 802 RSQIKEKDIEKMERKTFEKEKKIKHEHKSE-KDKLDLSECVDKIKEKDKLYSHHTEKCHK 860
Query: 614 KTEISE-----------KESKEKADMKHLRE--EKVSTRKESLQLHNVTKAEKPARVSKD 660
+ E S+ ++S+EK D KH +E EK ES + H + K K D
Sbjct: 861 EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNK----QSD 916
Query: 661 VEDVPASKKAKEGTED 676
+ S+K K +D
Sbjct: 917 NSEYSKSEKGKNKEKD 932
Score = 68.6 bits (166), Expect = 2e-11
Identities = 90/404 (22%), Positives = 165/404 (40%), Gaps = 60/404 (14%)
Query: 118 DEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEK-EKGK----- 171
++E D ++ E E P ++ +I + EK E+ + + K+ H+ K EK K
Sbjct: 780 EKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSE 839
Query: 172 --EKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEK 229
+K++EK+K T K E ++ T + K + K+ EK + K KE K EK
Sbjct: 840 CVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKE----KPEK 895
Query: 230 VKQTA-AKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSP 288
+ A +K K + + +K + + K+ K+++KD+
Sbjct: 896 ERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDR---------------------- 933
Query: 289 AIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKE-DIKKKSEKETAIDV 347
L ++ SR + K +++K V + EK +K+K++ E
Sbjct: 934 ----ELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPL--- 986
Query: 348 EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPA 407
K GK + K + + KD K + + K +E ++PK K K P
Sbjct: 987 -KTPDGKEKDKKDKDIDRYKERDKHKD-KIQINSLLKLKSEADKPK-PKSSPASKDTRP- 1042
Query: 408 KSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTS 467
KE + +D ++ ER +S+K + +K + ++Q+ ++ +
Sbjct: 1043 ----KEKRLVNDDLMQTSFER------MLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNC 1092
Query: 468 SILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKA-GKEVKPK 510
LK K+ K K + P K KE K +++ A KE +PK
Sbjct: 1093 LELKIKD--KEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPK 1134
Score = 65.9 bits (159), Expect = 1e-10
Identities = 102/471 (21%), Positives = 176/471 (37%), Gaps = 27/471 (5%)
Query: 134 DEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKK 193
D R+K K EK EK ++K H ++K K+ + +K +KEK +
Sbjct: 876 DREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDREL 935
Query: 194 EKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVK---EVQKTP-SKPKE 249
+K E + + EEK V G K + K + K K E KTP K K+
Sbjct: 936 DKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKD 995
Query: 250 KEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDL-KPGQSPAIPPPLPTEQA-----SRPT 303
K+DK+ + ++ ++ + D KP SPA P E+ T
Sbjct: 996 KKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQT 1055
Query: 304 PASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTV 363
L K+ E ++ KK + K+KEKE ++ ++ E I ++K +E+K +
Sbjct: 1056 SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKEL 1115
Query: 364 KIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVK 423
+K E + K K+P + + + + K S ++S+ ++ +
Sbjct: 1116 -----TRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSL--NRSPR 1168
Query: 424 AKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKV 483
++ E+ +VS+ + TT T R + +L+ E +
Sbjct: 1169 SENEKPGLSSRSVSMISVASSEDSCHTTVTTP---RPPVEYDSDFMLESSESQMSFSQSP 1225
Query: 484 PASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISE-KVQIHK 542
S+ K P + E S A + KPP ++ K ISE + I
Sbjct: 1226 FLSI-AKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEV 1284
Query: 543 QDIVKPEKTVSHGK-----PEEKVLKQVKAVTIEKTAKPKPTKKAEHRERE 588
+ P H K EE + V + + PKP + ER+
Sbjct: 1285 RRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERD 1335
Score = 48.9 bits (115), Expect = 2e-05
Identities = 117/615 (19%), Positives = 216/615 (35%), Gaps = 119/615 (19%)
Query: 136 PPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEK 195
P + + ++ K+ EK +RK+ ++ E+ ++ EKE PEKK T KE KK
Sbjct: 41 PKIERSDVSKEMKEKSSM-KRKLPFTISPSRNEE-RDSDTEKEGPEKKKTKKEAGNKKST 98
Query: 196 PETKTLAKEQKKAKTAEKSEEKTKKE-VKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDK- 253
P + + K + T ++ QT K+ + S+ K+K +K
Sbjct: 99 PVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKR 158
Query: 254 -EKAAVSKHEQ--KDQYAFCRYMIDIFVHGDLK--PGQSP-----------------AIP 291
E+ H + + +I + + ++K G +P A
Sbjct: 159 NERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAG 218
Query: 292 PPLPTEQASRPTP--------------------ASPALEEKEGEK-------KKAEKKVT 324
+ T+ TP +P K GE+ ++ E +
Sbjct: 219 ADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLK 278
Query: 325 SETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTV----------KIAAQAAAKKD 374
E + ++ SE+ +++ + SET++ ++ K +A +
Sbjct: 279 REVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEY 338
Query: 375 EKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKS-----PKKEHSVPSDKQVKAKTERA 429
E K+D + ++ +K+++KE E K+ +K S K K K R
Sbjct: 339 EFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRV 398
Query: 430 KEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGK-EEKVPASLK 488
S ++A+ KK + + + + K ++ + KGK + K+ K
Sbjct: 399 LYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNK 458
Query: 489 EKEPETKKDEKMSKAG-------------------------KEVKPK------------- 510
KE + K EK K K PK
Sbjct: 459 NKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTG 518
Query: 511 --PPQLQGKKEEKPEPQIKKEAKPAIS--EKVQIHKQDIVKPEKTVSHGKPEEKVLKQVK 566
P G E++ P ++ K +S + D+V+ + T S PE +K K
Sbjct: 519 KSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCK 578
Query: 567 AVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKA 626
++ +K + E E+ IK + P T E ++ KK + E ++ +K
Sbjct: 579 H---KEKSKHQKDFHLEFGEKSNAKIKDEDHSP----TFENSDCTLKKMD-KEGKTLKKH 630
Query: 627 DMKHLREEKVSTRKE 641
+KH EK +KE
Sbjct: 631 KLKHKEREKEKHKKE 645
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 98.6 bits (244), Expect = 2e-20
Identities = 147/617 (23%), Positives = 246/617 (39%), Gaps = 105/617 (17%)
Query: 134 DEPPLRKKEIHKDKTEKQEKPERKIQTK----VTHKEKEKGKEKVREKEKPEKKATHKEK 189
DE L+ K+I + E +QTK V+ + K+KGK K + K + + K + K
Sbjct: 430 DEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELK 489
Query: 190 IEKKEKPETKTLAKEQKKAKTAEKSEEKTKKE-------------------VKGGKQEKV 230
EK+ K T+ T EKT++E + GK K
Sbjct: 490 QEKEGKENTRIT---NLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPK- 545
Query: 231 KQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAI 290
+ + E Q TP K ++ K + E Q RY + P +S ++
Sbjct: 546 --HSCGLSEKQSTPLK--QEHTKTCLSPGSSEMSLQPDLVRYDN---TESEFLP-ESSSV 597
Query: 291 PPPLPTEQAS-----------------RPTPASPALEEKEGEKKKAEK--KVTSETKKKE 331
E++ + SP E + KK +K K + K K
Sbjct: 598 KSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKH 657
Query: 332 KEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQ 391
KE K+K +KE + EK + +++ Q +V+ + + K ++++ E E
Sbjct: 658 KEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHES 717
Query: 392 PKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTT 451
+K+ K EK+++ KS K++H V ++ K + ++ K+E ++ + KEE+
Sbjct: 718 LTLEKKSKLEKNIKDDKSTKEKH-VSKERNFKEERDKIKKESEKSFREEKIKDLKEER-- 774
Query: 452 KTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKP 511
+ I +K + +S+ + EE + L EKE + +K EK K KE K
Sbjct: 775 ----ENIPTDKDSEFTSL-----GMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKR 825
Query: 512 PQLQGKKEEKPEPQ-IKKEAKPAISEKVQIHKQD-------IVKPEKTVSH--GKPEEKV 561
Q++ K EK E + +KE K K + K D I + +K SH K ++
Sbjct: 826 SQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEG 885
Query: 562 LKQVKAVTIEKT--------------AKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEV 607
K I+KT K KP K+ E + + K K +
Sbjct: 886 EKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSK 945
Query: 608 TESGKKKTEISEKESKEKA---------DMKHLREEKVSTRKESLQLHNVTKAEKPARVS 658
+E GK K + E + KEK+ + KH++EEK K S+ N + EKP +
Sbjct: 946 SEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEK----KSSIVDGNKAQHEKPLSLK 1001
Query: 659 KDVEDVPASKKAKEGTE 675
+ +D P K +G E
Sbjct: 1002 EKTKDEPL--KTPDGKE 1016
Score = 94.4 bits (233), Expect = 3e-19
Identities = 144/618 (23%), Positives = 253/618 (40%), Gaps = 118/618 (19%)
Query: 130 KGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVR---EKEKPEKKATH 186
K E P + K +K+ K +K K+ HKE+EK K K EKEK + K +
Sbjct: 625 KDEDHSPTFENSDCTLKKMDKEGKTLKK--HKLKHKEREKEKHKKEIEGEKEKYKTKDSA 682
Query: 187 KE-----------------KIEKKE------KPETKTLAKEQKKAKTAEKSEEKTKKEVK 223
KE K ++ E + E+ TL K+ K K + ++K+ KE
Sbjct: 683 KELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIK--DDKSTKEKH 740
Query: 224 GGKQEKVKQTAAKVKEVQKTPSKPKE----KEDKEKAAVSKHEQKDQYAFCRYMIDIFVH 279
K+ K+ K+K+ + + ++ KE++E K + I +H
Sbjct: 741 VSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLH 800
Query: 280 GDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAE----KKVTSETKKKEKEDI 335
+ + E+ + S EK + K+ + ++ T E +KK K +
Sbjct: 801 ---------LVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEH 851
Query: 336 KKKSEK----ETAIDVEKKEPGKASET----KQGTVKIAAQAAAKKDEKKEDSKKTKKPA 387
K + +K E +++K+ + T K+G A K D++++ +K +
Sbjct: 852 KSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKH 911
Query: 388 EVEQPKGKKQ--EKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGK 445
+ E+P+ ++ E KEKH+ K+ + SD +K+E+ K + + K +
Sbjct: 912 DKEKPEKERHLAESKEKHLMEKKNKQ------SDNSEYSKSEKGKNKEKDRELDKKEKSR 965
Query: 446 KEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGK 505
+E T + I++EK SSI+ K + EK P SLKEK TK + + GK
Sbjct: 966 DKESINITNSKHIQEEKK---SSIVDGN---KAQHEK-PLSLKEK---TKDEPLKTPDGK 1015
Query: 506 EVKPKPPQLQGKKE--------------------EKPEPQIKKEAKPAISEKVQIHKQDI 545
E K + KE +KP+P+ +K ++ ++ D+
Sbjct: 1016 EKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDL 1075
Query: 546 VKP--EKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIK---TDKPK-- 598
++ E+ +S LK ++ K K K +K + R R ++ DK K
Sbjct: 1076 MQTSFERMLS--------LKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTK 1127
Query: 599 --PTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPAR 656
PT E+T S K +E+++ +KEK ++ VS R +S+ NV K +
Sbjct: 1128 HTPTESKNKELTRS--KSSEVTDAYTKEKQP-----KDAVSNRSQSVDTKNVMTLGKSSF 1180
Query: 657 VS-KDVEDVPASKKAKEG 673
VS + P S+ K G
Sbjct: 1181 VSDNSLNRSPRSENEKPG 1198
Score = 92.0 bits (227), Expect = 2e-18
Identities = 141/616 (22%), Positives = 243/616 (39%), Gaps = 76/616 (12%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVRE 176
E E DD DE+ +K D LRK++ +++ E ++ Q K + + K K
Sbjct: 360 EYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSK----- 414
Query: 177 KEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKE-VKGGKQEKVKQTAA 235
K+KP + + +E + K ++ S+ +TKKE V G+ ++ +
Sbjct: 415 KQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKR 474
Query: 236 KVKEVQKTPSK---PKEKEDKEKAAVS----------KHEQKDQYAFCRYMI---DIFVH 279
K+K K +EKE KE ++ + +++ F + D +H
Sbjct: 475 KLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLH 534
Query: 280 -GDLKPGQSP------AIPPPLPTEQASRPTPASPALEEK-------EGEKKKAEKKVTS 325
+ G+SP + P +Q T SP E + ++E S
Sbjct: 535 LFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPES 594
Query: 326 ETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKK 385
+ K K K K +K+ ++ +K K + + KK +K + K KK
Sbjct: 595 SSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDK--EGKTLKK 652
Query: 386 PAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGK 445
+ + K++ KKE E K K+ + + V+ E KE +
Sbjct: 653 HKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENF-------FKSDE 705
Query: 446 KEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGK 505
E+ + + EK K +KD + K K + KE+ + KK+ + S +
Sbjct: 706 TEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREE 765
Query: 506 EVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIH----KQDIVKPEKTV--SHGKPE- 558
++K + + +K + + AI E + +H + DI K EK + S KPE
Sbjct: 766 KIKDLKEERENIPTDK-DSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEK 824
Query: 559 -----EKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKK 613
EK +++++ T EK K K K+E +++ S DK K K S TE K
Sbjct: 825 RSQIKEKDIEKMERKTFEKEKKIKHEHKSE-KDKLDLSECVDKIKEKDKLYSHHTEKCHK 883
Query: 614 KTEISE-----------KESKEKADMKHLRE--EKVSTRKESLQLHNVTKAEKPARVSKD 660
+ E S+ ++S+EK D KH +E EK ES + H + K K D
Sbjct: 884 EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNK----QSD 939
Query: 661 VEDVPASKKAKEGTED 676
+ S+K K +D
Sbjct: 940 NSEYSKSEKGKNKEKD 955
Score = 68.6 bits (166), Expect = 2e-11
Identities = 90/404 (22%), Positives = 165/404 (40%), Gaps = 60/404 (14%)
Query: 118 DEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEK-EKGK----- 171
++E D ++ E E P ++ +I + EK E+ + + K+ H+ K EK K
Sbjct: 803 EKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSE 862
Query: 172 --EKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEK 229
+K++EK+K T K E ++ T + K + K+ EK + K KE K EK
Sbjct: 863 CVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKE----KPEK 918
Query: 230 VKQTA-AKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSP 288
+ A +K K + + +K + + K+ K+++KD+
Sbjct: 919 ERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDR---------------------- 956
Query: 289 AIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKE-DIKKKSEKETAIDV 347
L ++ SR + K +++K V + EK +K+K++ E
Sbjct: 957 ----ELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPL--- 1009
Query: 348 EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPA 407
K GK + K + + KD K + + K +E ++PK K K P
Sbjct: 1010 -KTPDGKEKDKKDKDIDRYKERDKHKD-KIQINSLLKLKSEADKPK-PKSSPASKDTRP- 1065
Query: 408 KSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTS 467
KE + +D ++ ER +S+K + +K + ++Q+ ++ +
Sbjct: 1066 ----KEKRLVNDDLMQTSFER------MLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNC 1115
Query: 468 SILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKA-GKEVKPK 510
LK K+ K K + P K KE K +++ A KE +PK
Sbjct: 1116 LELKIKD--KEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPK 1157
Score = 65.9 bits (159), Expect = 1e-10
Identities = 102/471 (21%), Positives = 176/471 (37%), Gaps = 27/471 (5%)
Query: 134 DEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKK 193
D R+K K EK EK ++K H ++K K+ + +K +KEK +
Sbjct: 899 DREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDREL 958
Query: 194 EKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVK---EVQKTP-SKPKE 249
+K E + + EEK V G K + K + K K E KTP K K+
Sbjct: 959 DKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKD 1018
Query: 250 KEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDL-KPGQSPAIPPPLPTEQA-----SRPT 303
K+DK+ + ++ ++ + D KP SPA P E+ T
Sbjct: 1019 KKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQT 1078
Query: 304 PASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTV 363
L K+ E ++ KK + K+KEKE ++ ++ E I ++K +E+K +
Sbjct: 1079 SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKEL 1138
Query: 364 KIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVK 423
+K E + K K+P + + + + K S ++S+ ++ +
Sbjct: 1139 -----TRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSL--NRSPR 1191
Query: 424 AKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKV 483
++ E+ +VS+ + TT T R + +L+ E +
Sbjct: 1192 SENEKPGLSSRSVSMISVASSEDSCHTTVTTP---RPPVEYDSDFMLESSESQMSFSQSP 1248
Query: 484 PASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISE-KVQIHK 542
S+ K P + E S A + KPP ++ K ISE + I
Sbjct: 1249 FLSI-AKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEV 1307
Query: 543 QDIVKPEKTVSHGK-----PEEKVLKQVKAVTIEKTAKPKPTKKAEHRERE 588
+ P H K EE + V + + PKP + ER+
Sbjct: 1308 RRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERD 1358
Score = 42.7 bits (99), Expect = 0.001
Identities = 123/637 (19%), Positives = 214/637 (33%), Gaps = 143/637 (22%)
Query: 114 ISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEK 173
IS E+ D D D+D G E ER I + T+ EKE
Sbjct: 66 ISPSRNEERDSDTDSDPGHTSE----------------NWGERLISSYRTYSEKEG---- 105
Query: 174 VREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKE-VKGGKQEKVKQ 232
PEKK T KE KK P + + K + T ++ Q
Sbjct: 106 ------PEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQ 159
Query: 233 TAAKVKEVQKTPSKPKEKEDK--EKAAVSKHEQ--KDQYAFCRYMIDIFVHGDLK--PGQ 286
T K+ + S+ K+K +K E+ H + + +I + + ++K G
Sbjct: 160 TTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGW 219
Query: 287 SP-----------------AIPPPLPTEQASRPTP--------------------ASPAL 309
+P A + T+ TP +P
Sbjct: 220 TPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQ 279
Query: 310 EEKEGEK-------KKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGT 362
K GE+ ++ E + E + ++ SE+ +++ + SET++ +
Sbjct: 280 ANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDS 339
Query: 363 V----------KIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKS--- 409
+ K +A + E K+D + ++ +K+++KE E K+
Sbjct: 340 LICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLF 399
Query: 410 --PKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTS 467
+K S K K K R S ++A+ KK + + + + K
Sbjct: 400 AKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKE 459
Query: 468 SILKDKEPIKGK-EEKVPASLKEKEPETKKDEKMSKAG---------------------- 504
++ + KGK + K+ K KE + K EK K
Sbjct: 460 YVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEG 519
Query: 505 ---KEVKPK---------------PPQLQGKKEEKPEPQIKKEAKPAIS--EKVQIHKQD 544
K PK P G E++ P ++ K +S + D
Sbjct: 520 NFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPD 579
Query: 545 IVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGT 604
+V+ + T S PE +K K ++ +K + E E+ IK + P T
Sbjct: 580 LVRYDNTESEFLPESSSVKSCKH---KEKSKHQKDFHLEFGEKSNAKIKDEDHSP----T 632
Query: 605 SEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKE 641
E ++ KK + E ++ +K +KH EK +KE
Sbjct: 633 FENSDCTLKKMD-KEGKTLKKHKLKHKEREKEKHKKE 668
Score = 37.7 bits (86), Expect = 0.038
Identities = 82/437 (18%), Positives = 152/437 (34%), Gaps = 61/437 (13%)
Query: 293 PLPTEQASRPTPASPA-LEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKE 351
P E+ T + P E GE+ + + SE + EK+ KK++ + + V
Sbjct: 68 PSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKSTPVSILF 127
Query: 352 PGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQP--KGKKQEKKEKHVEPAKS 409
SE KQ + + A + + PA+ + P ++++K K E ++
Sbjct: 128 GYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGET 187
Query: 410 PKKEHSVPSD-KQVKAKTERAKE----------------EIGAVSIKKAVPGKKEEKTTK 452
P ++ D KQVK +G + K + + T+
Sbjct: 188 PLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQ 247
Query: 453 TVEQE--IRKEKSGKTSSILK---------------DKEPIKGKE-EKVPASLKEKEPET 494
++ + + S I+K + P+ E E++ LK + P +
Sbjct: 248 GLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLS 307
Query: 495 KKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQI----------KKEAKPAISEKVQIHKQD 544
DE + + + P + + + E K P+ ++ + D
Sbjct: 308 DDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDD 367
Query: 545 IVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKP----- 599
+ K + K ++ EKT +KA + P S K+ K KP
Sbjct: 368 DEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFY----PKSFKSKKQKPSRVLY 423
Query: 600 --TPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARV 657
T E ++ K T S +DM+ +E VS E Q V + K
Sbjct: 424 SSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVS--GEHKQKGKVKRKLKNQNK 481
Query: 658 SKDVEDVPASKKAKEGT 674
+K+ +++ K+ KE T
Sbjct: 482 NKENQELKQEKEGKENT 498
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 98.2 bits (243), Expect = 2e-20
Identities = 105/574 (18%), Positives = 279/574 (48%), Gaps = 40/574 (6%)
Query: 112 DIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGK 171
D + E+EE + +T + +E ++ + + +++E+ RK++ + +E+++ +
Sbjct: 235 DRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQE-E 293
Query: 172 EKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVK 231
E+ +++ + E++ K++ E++E+ E + +E++ E+ EE+ +++++ ++E+ +
Sbjct: 294 EQQQQRLRREQQLRRKQEEERREQQEERREQQERR-----EQQEERREQQLRREQEERRE 348
Query: 232 QTAAKVKEVQKTPS--KPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPA 289
Q + +E ++ + +++E++ + + + +Q + R + L+ Q
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 408
Query: 290 IPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKED----IKKKSEKETAI 345
L EQ R +E+E ++K E++ + K+E+E+ +K++ E E
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHE 468
Query: 346 DVEKKEPGK---ASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEK 402
+K+ K E ++ +K+ + ++ E++E + ++ EQ + K+QE++E
Sbjct: 469 QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ-RLKRQEEEE- 526
Query: 403 HVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEK 462
+ + + S++Q++ + E +E++ +K + ++ E+ K EQE R+++
Sbjct: 527 --------RLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKR-EQEERRDQ 577
Query: 463 SGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKP 522
K + + + +EE++ LK +E E + E+ + + +K + P EE+
Sbjct: 578 LLKREEERRQQRLKREQEERLEQRLKREEVERLEQEE--RREQRLKREEP------EEER 629
Query: 523 EPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKA 582
Q+ K + + Q+ ++ + E+ + + EE++ +++K E+ + + ++
Sbjct: 630 RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE 689
Query: 583 EHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKES 642
+ + RE IK+ PK + S E+ +++++ + K++ + +E+ R+ES
Sbjct: 690 QEQARE--RIKSRIPKWQWQLES---EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES 744
Query: 643 -LQLHNVTKAEKPARVSKDVEDVPASKKAKEGTE 675
LQ +A + + + D +A+E +E
Sbjct: 745 ELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778
Score = 91.3 bits (225), Expect = 3e-18
Identities = 100/615 (16%), Positives = 286/615 (46%), Gaps = 94/615 (15%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKK---EIHKDKTEKQEKPERK-----IQTKVTHKEKE 168
++ E +G+E ++K E E R++ E+ + + E QE+ ER+ +Q+ H+ +E
Sbjct: 144 QERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEE 203
Query: 169 -KGKEKVREKEKPE-----KKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEV 222
+E++R +E E ++ +++ E++++ + KE +K +T + EE+ +E
Sbjct: 204 FPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE 263
Query: 223 KGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDL 282
+ +Q ++++ +++++++ + + +E++++ + EQ+ L
Sbjct: 264 EPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQ-----------------L 306
Query: 283 KPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKE 342
+ Q E+ + E +E ++++ E+++ E +++ ++ ++++ E+E
Sbjct: 307 RRKQE--------EERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEE 358
Query: 343 TAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQ----- 397
++E + E ++ ++ Q ++ ++E + ++ EQ ++Q
Sbjct: 359 RREQQLRRE--QEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 416
Query: 398 ------------EKKEKHVEPAKSPKKEHSVPSDKQVK-------AKTERAKEEIGAVSI 438
+++E+H + + ++E + +++ + +TER ++E +
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476
Query: 439 KKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDE 498
K+ ++ E+ K E+E R+++ + + ++ +EE+ LK +E E + +
Sbjct: 477 KRDQEEERRERWLKLEEEERREQQERREQQLRRE------QEERREQRLKRQEEEERLQQ 530
Query: 499 KM---SKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHG 555
++ + +E + + QL ++EEK Q ++E + + + + + ++K E+
Sbjct: 531 RLRSEQQLRREQEERREQLLKREEEKRLEQERREQR--LKREQEERRDQLLKREE----- 583
Query: 556 KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKT 615
+ ++ LK+ + +E+ K + ++ E ER +K ++P+ +++
Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEE------------ERRQ 631
Query: 616 EISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTE 675
++ + E +E+ + LR E+ R++ L+ + R+ ++ E+ ++ E +
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLK-REEEEERLEQRLKREHEEERREQELAEEEQ 690
Query: 676 DVSPTKQKSPISFFQ 690
+ + + KS I +Q
Sbjct: 691 EQARERIKSRIPKWQ 705
Score = 90.1 bits (222), Expect = 6e-18
Identities = 88/575 (15%), Positives = 270/575 (46%), Gaps = 46/575 (8%)
Query: 134 DEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKK 193
+E ++E +++ E++E+ E + + ++ +++E+ ++++R +++ E++ + +++
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370
Query: 194 EKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDK 253
E+ E + ++Q + + + E++ ++E + +++++++ +E Q + +E +
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQE 430
Query: 254 EKAAVSKHEQKDQYAFCRYMID-----IFVHGDLKPGQSPAIPPPLPTEQASRPTPASPA 308
E+ KHEQ+ + + + + + + + L +Q
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490
Query: 309 LEEKE--GEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIA 366
LEE+E ++++ E+++ E +++ ++ +K++ E+E + E E ++ ++
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Query: 367 AQAAAKK--DEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKA 424
+ K+ E++E K ++ +Q +++E++++ ++ + + E + ++ +
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610
Query: 425 KTERAKEEIGAVSIKKAVPGK-------KEEKTTKTVEQEIRKEKSGKTSSILKDKEPIK 477
+ E +E+ +K+ P + K E+ + +Q++R+E+ + LK +E
Sbjct: 611 EQEERREQ----RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREE--- 663
Query: 478 GKEEKVPASLKEKEPETKK-----DEKMSKAGKEVKPKPPQLQGKKE-----------EK 521
+EE++ LK + E ++ +E+ +A + +K + P+ Q + E +
Sbjct: 664 -EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR 722
Query: 522 PEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKK 581
P Q + + EK + + ++ E+ +H + +E+ +Q + T + A+ K +
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE--EQRRDFTWQWQAEEKSERG 780
Query: 582 AEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKE 641
+ PP ++ + + +E + +++ E+E +++ + RE+++ +E
Sbjct: 781 RQRLSARPP-LREQRERQL---RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 642 SLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTED 676
QL +A++ +++ ++++E D
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871
Score = 85.9 bits (211), Expect = 1e-16
Identities = 97/575 (16%), Positives = 271/575 (47%), Gaps = 54/575 (9%)
Query: 114 ISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEK 173
+ E EE D + ++ E E RK+++ +D+ E++ + K++ + +++E+ +++
Sbjct: 447 LKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQ 506
Query: 174 VREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKK-EVKGGKQEKVKQ 232
+R +E+ E++ ++ E++E+ + + +++Q + + E+ E+ K+ E K +QE+ +Q
Sbjct: 507 LR-REQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQ 565
Query: 233 TAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPP 292
+ +E ++ +E+E +++ + E++ + R ++ + + + +
Sbjct: 566 RLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL---EQEERREQRLKR 622
Query: 293 PLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEP 352
P E+ + S EE+ ++ + E++ E + K +E+ ++ ++ E++
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE 682
Query: 353 GKASETKQGTVKIAAQAAAKK----DEKKEDSKKTKKPAEVEQPKG--KKQEKKEK---- 402
+ +E +Q + ++ K E + D++++K + + +G ++QE++EK
Sbjct: 683 QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742
Query: 403 -------HVEPAKSPKKEHSVPSD----KQVKAKTERAKEEIGA------VSIKKAVPGK 445
E A ++E D Q + K+ER ++ + A ++ +
Sbjct: 743 ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE 802
Query: 446 KEEKTTKTVEQEIRKE-------KSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDE 498
++++ + + +E KE + K L+++E ++ +E L+E+E ++D+
Sbjct: 803 RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRER--AQQLQEEEDGLQEDQ 860
Query: 499 KMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEK-------VQIHKQDIVKPEKT 551
+ ++ ++ + + + Q +EE+ + AKPA+ E+ +Q ++++ + E+
Sbjct: 861 ERRRSQEQRRDQKWRWQ-LEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE 919
Query: 552 VSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESG 611
+ +E+ ++ + + E+ + ++ R+ + DK + E
Sbjct: 920 KRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPE 979
Query: 612 KKKTEISEKESKEKADMKH-----LREEKVSTRKE 641
K++ + EK+ +E+ +++ LREE+ R++
Sbjct: 980 KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014
Score = 84.7 bits (208), Expect = 3e-16
Identities = 99/598 (16%), Positives = 282/598 (47%), Gaps = 55/598 (9%)
Query: 110 LSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEK 169
L + SE + + +E ++ E R ++ +++ K+E+ ER+ Q +E+ +
Sbjct: 528 LQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQ 587
Query: 170 GKEKVREKEKPEK--KATHKEKIEKKEKPETKTLAKEQKKAK-----TAEKSEEKTKKEV 222
+ K ++E+ E+ K E++E++E+ E + +E ++ + +E+ EE+ ++++
Sbjct: 588 QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL 647
Query: 223 KGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDL 282
+ +QE+ +Q + +E ++ + K + ++E+ E++ + A R I
Sbjct: 648 RREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRI------ 701
Query: 283 KPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKE 342
P L +E +R + ++EG++++ E+ E K++ +E + E+E
Sbjct: 702 -----PKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQ----EEKRRRRESELQWQEEE 752
Query: 343 TAIDVEKKEPGK---------ASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPK 393
A +++E + ++++G +++A+ + E++E + ++ + EQ
Sbjct: 753 RAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLR--EQRERQLRAEERQQREQRF 810
Query: 394 GKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERA----KEEIGA---VSIKKAVPGKK 446
++E+KE+ + +KE +++ + ERA +EE G +++ ++
Sbjct: 811 LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRR 870
Query: 447 EEKTTKTVEQEIRK------------EKSGKTSSILKDKEPIKGKEEKVPASLKEKEPET 494
++K +E+E ++ E+ K +L+++E +EE+ +E+E +
Sbjct: 871 DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930
Query: 495 KKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSH 554
+++E++ + +++ + + + ++ ++ E Q +K+ K E+ + ++ + +
Sbjct: 931 REEEQLQQEEEQLLRE--EREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK 988
Query: 555 GKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKK 614
EE+ L+Q + + + + + ++ E + R+ ++ ++ + + E +++
Sbjct: 989 KYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEE-EQLLREEREKRRLQERE 1047
Query: 615 TEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKE 672
+ E+E ++ + + L EE+ + R++ L+ + E + + + P ++ +E
Sbjct: 1048 RQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE 1105
Score = 80.1 bits (196), Expect = 7e-15
Identities = 94/599 (15%), Positives = 276/599 (46%), Gaps = 70/599 (11%)
Query: 108 SLLSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEK 167
SLL D EED E D+ +EP R+++ K+++ ER++ EK
Sbjct: 108 SLLQD---RRQEEDQRRFEPRDRQLEEEPGQRRRQ-------KRQEQERELAEGEEQSEK 157
Query: 168 -EKGKEKVREK------------EKPEKKATHKEKI------EKKEKPETKTLAK----E 204
E+ +++ R++ ++ E++ +E++ E +E P+ + L + E
Sbjct: 158 QERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLE 217
Query: 205 QKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQK 264
++ EK +++ +++ + ++E+ K+ + ++K K +E+E + + + + E++
Sbjct: 218 LRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQ 277
Query: 265 DQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVT 324
R + + + + + L EQ R E++E +++ E++
Sbjct: 278 -----LRKLERQELRRERQEEEQQ--QQRLRREQQLRRKQEEERREQQEERREQQERREQ 330
Query: 325 SETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTK 384
E +++++ +++ +E + E++E + + ++ + + +++++ ++ +
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390
Query: 385 KPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPG 444
+ +Q + ++Q ++E+ + + ++E + ++Q++ + E + E
Sbjct: 391 RE---QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHE------------ 435
Query: 445 KKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAG 504
+K E+ + EQ +++E+ + + +++E + ++E+ LK + E +++ +
Sbjct: 436 QKHEQERR--EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493
Query: 505 KEVKP----KPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEK 560
+E + + QL+ ++EE+ E ++K++ + ++ +Q + + ++ + E+
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE-----ERREQ 548
Query: 561 VLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTD---KPKPTPKGTSEVTESGKKKTEI 617
+LK+ + +E+ + + K+ E ER +K + + + + E E K+ E+
Sbjct: 549 LLKREEEKRLEQERREQRLKR-EQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEV 607
Query: 618 SEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTED 676
E +E+ + + REE R++ L + + ++ ++ ++ + +E E+
Sbjct: 608 ERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666
Score = 77.4 bits (189), Expect = 4e-14
Identities = 100/625 (16%), Positives = 275/625 (44%), Gaps = 89/625 (14%)
Query: 113 IISSEDEEDDDGDEDTDKGEIDEPPLRKKE--------IHKDKTEKQEKPERKIQ----T 160
++ E+EE + + + + E R++E + +++ EK+ + ER+ Q
Sbjct: 905 LLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDK 964
Query: 161 KVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKK 220
K+ KE++ E+ ++ + E++ ++E+ E+ ++ E + L +E++K + E + KK
Sbjct: 965 KLQQKEEQLLGEEPEKRRRQEREKKYREE-EELQQEEEQLLREEREKRRRQEWERQYRKK 1023
Query: 221 EVKGGKQEKVKQTAAKVKEVQKTPSKPKEKED----------KEKAAVSKHEQKDQYAFC 270
+ ++E++ + + + +Q+ + +E+E+ +E+ + E + QY
Sbjct: 1024 DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR-- 1081
Query: 271 RYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGE-------KKKAEKKV 323
+L+ + EQ R P +E+E + +++ E+ +
Sbjct: 1082 -------KEEELQQEE----------EQLLREEPEKRRRQERERQCREEEELQQEEEQLL 1124
Query: 324 TSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKT 383
E +K+ +++++++ +E + E+++ + K+ ++ Q +++ ++E+ +
Sbjct: 1125 REEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL 1184
Query: 384 KKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKA-V 442
++ E + + ++Q ++E+ ++ K +K+ D++ K + E+ AV K
Sbjct: 1185 REEQEKRRQERERQYREEEELQRQK--RKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYC 1242
Query: 443 PGKKEEKTTKTVEQEIRKEKSGKTSSIL------KDKEPIKGKEEKVPASLKEKEPETKK 496
G++ E+ + + ++R +S + L +D+E + + ++ E+E ++
Sbjct: 1243 KGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLERE 1302
Query: 497 DEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQI---------------- 540
++K +K + QL +EE+ E + ++E E+ Q+
Sbjct: 1303 EQKEAKRRDRKSQEEKQL--LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDR 1360
Query: 541 --------HKQD---IVKPEKTVSHGKPEEKVLKQVKAVTI-EKTAKPKPTKKAEHRERE 588
H++ ++ E+ + + E K LK+ + + E+ + + + + RE E
Sbjct: 1361 KFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEE 1420
Query: 589 PPSIKTDKPKPTPKGTSEVTESGKKKTEISEKES-KEKADMKHLREEKVSTRKESLQLHN 647
+ ++ + + +V +++ + E++ +++ K EE++ +E QLH
Sbjct: 1421 QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR 1480
Query: 648 VTKAEKPARVSKDVEDVPASKKAKE 672
+ K + + +K +E
Sbjct: 1481 QERDRKFLEEEQQLRRQERDRKFRE 1505
Score = 75.9 bits (185), Expect = 1e-13
Identities = 103/594 (17%), Positives = 274/594 (46%), Gaps = 57/594 (9%)
Query: 110 LSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEK 169
L + E+ E + +E ++ E P ++ K+E+QE ER+ Q ++ +++E+
Sbjct: 598 LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE--ERR-QQQLRREQQER 654
Query: 170 GKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSE----EKTKKEVKGG 225
+++++ +E+ E+ ++ ++E+ E + +EQ++A+ KS + +
Sbjct: 655 REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADA 714
Query: 226 KQEKV-----KQTAAKVKEVQKTPSKPKEKE----DKEKAAVSKHEQKDQYAFC-RYMID 275
+Q KV KQ + ++ Q+ + +E E ++E+A + E++ + F ++ +
Sbjct: 715 RQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAE 774
Query: 276 IFVHGDLKPGQSPAIPPPL---------PTEQASRPTPASPALEEKEGEKKKAEKKVTSE 326
+ Q + PPL E+ R P EEKE +++ ++
Sbjct: 775 ---EKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831
Query: 327 TKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTK-- 384
+E+E +++ +E A ++++E G + ++ + + + + +E+ K+ +
Sbjct: 832 QFLEEEEQLQR---RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHT 888
Query: 385 ---KPAEVEQPKGKKQEKKEKHVEPAKSPK-KEHSVPSDKQVKAKTERAKEEIGAVSIKK 440
KPA EQ + ++Q +E+ E + + K ++Q + + + +EE ++
Sbjct: 889 LYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE------EQ 942
Query: 441 AVPGKKEEKTTKTVEQEIRKEKS-GKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEK 499
+ ++E++ + E++ RK+K + L +EP K + ++ +E+E +++E+
Sbjct: 943 LLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQ 1002
Query: 500 MSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHK-QDIVKPEKTVSHGKPE 558
+ +E + K + + +++ + + ++++E + + E+ + + Q+ + + + E
Sbjct: 1003 LL---REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQE 1059
Query: 559 EKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEIS 618
E+ L + T + + +K E ++E + ++P E +++ +
Sbjct: 1060 EEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEP--------EKRRRQERERQCR 1111
Query: 619 EKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKE 672
E+E ++ + + LREE+ R++ L+ + E + + + P ++ +E
Sbjct: 1112 EEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQE 1165
Score = 72.8 bits (177), Expect = 1e-12
Identities = 85/560 (15%), Positives = 259/560 (46%), Gaps = 52/560 (9%)
Query: 135 EPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKI---- 190
E P +++ +++ ++E+ ++ + ++ +E+EK + + E++ E++ +E+
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155
Query: 191 EKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEK 250
E+ EK + L ++ ++ + ++ EE+ +E + ++++ ++ + +E+Q+ K + +
Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR 1215
Query: 251 EDKEKAAV-------SKHEQKDQYAFCR----YMIDIFVHGDLKPGQSPAIPPPLPTEQA 299
++ +++ + ++ +D +C+ L+ QS L EQ
Sbjct: 1216 DEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQ 1275
Query: 300 SRPT--------------PASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAI 345
R P LE +E ++ K + + E K+ +E+ ++K ++
Sbjct: 1276 ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD 1335
Query: 346 DVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHV- 404
++E E ++ ++ + ++E+ ++ +K E EQ + ++QE++ K +
Sbjct: 1336 RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQ-RLRRQERERKFLK 1394
Query: 405 --EPAKSPKKEHSVPSDKQVKAKTER---AKEEIGAVSIKKAVPGKKEEKTTKTV--EQE 457
+ + ++E + D+ K + E +++E ++ +++E+ K + EQ+
Sbjct: 1395 EEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ 1454
Query: 458 IRKEKSGK---TSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSK-AGKEVKPKPPQ 513
+R+E+ K +L+++E + ++ E+E + ++ E+ K +E++ + P+
Sbjct: 1455 LRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPE 1514
Query: 514 LQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKT 573
+ +EE+ + +++ K + E+ Q+ +Q E+ + ++ ++ + + E+
Sbjct: 1515 RKFLEEEQQLHRQQRQRK-FLQEEQQLRRQ-----ERGQQRRQDRDRKFREEEQLRQERE 1568
Query: 574 AKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLRE 633
+ ++ + + R ++ K + + + + + + + +++ +++ D K +
Sbjct: 1569 EQQLSRQERDRKFR----LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRED 1624
Query: 634 EKVSTRKESLQLHNVTKAEK 653
E++ +E QLH + K
Sbjct: 1625 EQLLQEREEQQLHRQERDRK 1644
Score = 64.3 bits (155), Expect = 4e-10
Identities = 83/496 (16%), Positives = 229/496 (46%), Gaps = 36/496 (7%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVRE 176
E+E+ E K +E LR++ K + E+Q ER+ Q + K E+ ++
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ 1493
Query: 177 KEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAK 236
+ E+ +E+ + ++PE K L +EQ+ + ++ + ++E + +QE+ +Q +
Sbjct: 1494 LRRQERDRKFREQELRSQEPERKFLEEEQQLHR-QQRQRKFLQEEQQLRRQERGQQ--RR 1550
Query: 237 VKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPT 296
+K + + ++++E+ +S+ E+ ++ + K + +
Sbjct: 1551 QDRDRKFREEEQLRQEREEQQLSRQERDRKFRL----------EEQKVRRQEQERKFMED 1600
Query: 297 EQASRPTPASPALEEKEGEKKKAEKKVTSETKKKE---KEDIKKKSEKETAIDVEKKEPG 353
EQ R L ++ K + ++++ E ++++ +E +K E+E + +++E
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQ- 1659
Query: 354 KASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKK- 412
+ + + Q + +E++ ++ + E+ + ++QE++ K ++ + ++
Sbjct: 1660 QLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQ 1719
Query: 413 --EHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSIL 470
E ++Q++ +TE +E++ + + +++ + + +Q R+E+ K
Sbjct: 1720 ELERKFREEEQLRQETE--QEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRK----F 1773
Query: 471 KDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGK--------KEEKP 522
+++E ++ + E+ +E + + +++E++ + +E + +P Q GK + E+
Sbjct: 1774 REEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQ 1833
Query: 523 EPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKA 582
E ++++E + Q Q+ + E+ + E+K ++ + E+ + + +K
Sbjct: 1834 EQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQ--QKE 1891
Query: 583 EHREREPPSIKTDKPK 598
E R R+ IK+ + K
Sbjct: 1892 EQRHRQVGEIKSQEGK 1907
Score = 62.8 bits (151), Expect = 1e-09
Identities = 84/565 (14%), Positives = 251/565 (44%), Gaps = 47/565 (8%)
Query: 108 SLLSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEK 167
S L D S +D + G++ E + ++++ H + E+ E+ E+K + K +
Sbjct: 1256 SQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQ 1315
Query: 168 E------KGKEKVREKEKPEKKATHKEKI--EKKEKP-------------------ETKT 200
E + +E+ R +++ ++K +E++ E++E+P + +
Sbjct: 1316 EEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK 1375
Query: 201 LAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAA------KVKEVQKTPSKPKEKEDKE 254
+E+++ + E+ + K+E + QE+ +Q + +E Q + + K +E
Sbjct: 1376 FLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREE 1435
Query: 255 KAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEG 314
+ V + E++ ++ + H + + + +Q R LEE++
Sbjct: 1436 EQQVRRQERERKFLEEEQQLRQERHRKFR--EEEQLLQEREEQQLHRQERDRKFLEEEQQ 1493
Query: 315 EKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKD 374
+++ + E + + +E +K E+E + ++++ E +Q + Q +
Sbjct: 1494 LRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDR 1553
Query: 375 EKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIG 434
++K ++ + EQ +++ ++ +E K ++E +++ ++ + + G
Sbjct: 1554 DRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQE----QERKFMEDEQQLRRQEG 1609
Query: 435 AVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPET 494
+++ K E E+E ++ + ++EP ++E+ +++ +
Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF 1669
Query: 495 KKDEKMSKAGKEVKPKPPQLQGK-KEEKPEPQIKKEAKPAISEKVQIHKQDI---VKPEK 550
+++E++ + G+E + + + K +EE+ + + ++ + + E+ Q+ +Q++ + E+
Sbjct: 1670 REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE 1729
Query: 551 TVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTES 610
+ +E++ +Q + I + + +P ++ + R+ + D+ + + E
Sbjct: 1730 QLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQ----ERDRKFREEEQLRQEREE 1785
Query: 611 GKKKTEISEKESKEKADMKHLREEK 635
+ +++ S+++ +E+ ++ REE+
Sbjct: 1786 QQLRSQESDRKFREEEQLRQEREEQ 1810
Score = 62.0 bits (149), Expect = 2e-09
Identities = 95/624 (15%), Positives = 269/624 (43%), Gaps = 88/624 (14%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKE-----KGK 171
+ EE+ E+ +K + E R+++ +++ +QE+ + + + T + +E + +
Sbjct: 1027 QQEEEQLLREEREKRRLQE---RERQYREEEELQQEEEQLLGEERETRRRQELERQYRKE 1083
Query: 172 EKVRE------KEKPEKKATHKEK-----------------IEKKEKPETKTLAKEQKKA 208
E++++ +E+PEK+ + + E++EK + L ++ ++
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143
Query: 209 KTAEKSEEKTKKE--VKGGKQEKVKQTAAK----------VKEVQKTPSKPKEKEDKEKA 256
+ ++ EE+ +E K +QE +Q + ++E Q+ + +E++ +E+
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEE 1203
Query: 257 AVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEK 316
+ + ++K +Y D DLK P E A R E E +
Sbjct: 1204 ELQRQKRKQRYR------DEDQRSDLKWQWEP------EKENAVRDNKVYCKGRENEQFR 1251
Query: 317 KKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEK 376
+ + ++ +++ + + + + E+ + +Q + +++E+
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQ-------ERDREQERRRWQQRDRHFPEEEQLEREEQ 1304
Query: 377 KEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAV 436
KE ++ +K E +Q +++E+K + E + ++E + +++ + + ++
Sbjct: 1305 KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDR---- 1360
Query: 437 SIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKV------PASLKEK 490
+ + +E+ K +E+E R + + LK+++ ++ +E + +E+
Sbjct: 1361 -KFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREE 1419
Query: 491 EPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQI----HKQDIV 546
E + + E+ K +E + Q + +K + E Q+++E E+ Q+ +Q +
Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479
Query: 547 KPEKTVSHGKPEEKVLKQV--KAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGT 604
+ E+ + E+++ +Q + ++ +P +K E++ + + +
Sbjct: 1480 RQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQ 1539
Query: 605 SEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKE-----SLQLHNVTKAEKPARVSK 659
E G+++ + +++ +E+ ++ REE+ +R+E L+ V + E+ + +
Sbjct: 1540 LRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFME 1599
Query: 660 DVEDVPASKKAKEGTEDVSPTKQK 683
D + + + +EG + + + +
Sbjct: 1600 DEQQL----RRQEGQQQLRQERDR 1619
Score = 53.1 bits (126), Expect = 9e-07
Identities = 58/389 (14%), Positives = 180/389 (46%), Gaps = 40/389 (10%)
Query: 139 RKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPET 198
R ++ +++ +QE+ E+++ + ++ ++KVR +E+ K ++++ ++E +
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ 1612
Query: 199 KTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAV 258
+++K + + +E+ ++++ +QE+ ++ + ++++ + + + D+++
Sbjct: 1613 LRQERDRKFREDEQLLQEREEQQLH--RQERDRKFLEEEPQLRRQEREQQLRHDRDR--- 1667
Query: 259 SKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGE--K 316
K +++Q L+ G+ EQ R E+E + +
Sbjct: 1668 -KFREEEQL--------------LQEGE----------EQQLRRQERDRKFREEEQQLRR 1702
Query: 317 KKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEK 376
++ E+K E ++ ++++++K +E + E ++ + + + Q +++E+
Sbjct: 1703 QERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQ 1762
Query: 377 K-EDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDK-------QVKAKTER 428
+ ++ +K E EQ + +++E++ + E + ++E + ++ Q + R
Sbjct: 1763 QLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYR 1822
Query: 429 AKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLK 488
+EE + ++ ++ ++ + EQ +EKS + L +E K ++E+ +
Sbjct: 1823 WEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLRE 1882
Query: 489 EKEPETKKDEKMSKAGKEVKPKPPQLQGK 517
E +K+E+ + E+K + + G+
Sbjct: 1883 EHIRRQQKEEQRHRQVGEIKSQEGKGHGR 1911
Score = 42.4 bits (98), Expect = 0.002
Identities = 50/300 (16%), Positives = 140/300 (46%), Gaps = 26/300 (8%)
Query: 113 IISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKE 172
++ +E+ E K +EP LR++E E+Q + +R + + + ++G+E
Sbjct: 1627 LLQEREEQQLHRQERDRKFLEEEPQLRRQE-----REQQLRHDRDRKFREEEQLLQEGEE 1681
Query: 173 KVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQ 232
+ +++ ++K +E+ ++++ E K L +EQ+ + + E+ +E + +QE ++
Sbjct: 1682 QQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRR---QELERKFREEEQLRQETEQE 1738
Query: 233 TAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPP 292
+ + +K + + + ++E+ + + E+ ++ + + +
Sbjct: 1739 QLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFR------------EEEQLRQEREEQ 1786
Query: 293 PLPTEQASRPTPASPAL-EEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKE 351
L ++++ R L +E+E ++ + +++ + K + +E+ + E+E + E+
Sbjct: 1787 QLRSQESDRKFREEEQLRQEREEQQLRPQQR---DGKYRWEEEQLQLEEQEQRLRQERDR 1843
Query: 352 PGKASE--TKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKS 409
+A E Q + Q +++E+K ++ +K E + +K+E++ + V KS
Sbjct: 1844 QYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKS 1903
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 96.3 bits (238), Expect = 9e-20
Identities = 135/602 (22%), Positives = 231/602 (38%), Gaps = 101/602 (16%)
Query: 115 SSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKV 174
SS D ED +E+ E+ PP +K + ++ P K K + E +E
Sbjct: 83 SSSDSEDSSEEEE----EVQGPPAKKAAV---PAKRVGLPPGKAAAKAS--ESSSSEESS 133
Query: 175 REKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTA 234
+ ++ ++K K+ ++K KP+ K KKAK+++ S+ + E + K +K K T
Sbjct: 134 DDDDEEDQK---KQPVQKGVKPQAKAAKAPPKKAKSSD-SDSDSSSEDEPPKNQKPKITP 189
Query: 235 AKVKEVQKTPSKPKEKEDK---EKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIP 291
VK K P KP K KAA S + + K +
Sbjct: 190 VTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVV 249
Query: 292 PPLPTEQASRPTPASPALEEKEGEKKKAEKKV------------------------TSET 327
P + A+ PT S + E+ ++++ +KK T
Sbjct: 250 AKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPP 309
Query: 328 KKK-EKEDIKKKSE-----KETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSK 381
KK EK+ + SE +++ + EKK P KA +K T A+ AA+ DS
Sbjct: 310 KKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSD 369
Query: 382 KTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKA 441
++ +P G + K KSP + + + V + + + S ++
Sbjct: 370 SSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEE 429
Query: 442 VPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMS 501
+EEKT K V + + + K + L K+ +G + +S + +++EK S
Sbjct: 430 SSSSEEEKTKKMV-ATTKPKATAKAALSLPAKQAPQGSRDS--SSDSDSSSSEEEEEKTS 486
Query: 502 KAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKV 561
K+ VK KP ++ G +KPA ++K K + + + EE+
Sbjct: 487 KSA--VKKKPQKVAGG---------AAPSKPASAKK---GKAESSNSSSSDDSSEEEEEK 532
Query: 562 LKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKE 621
LK K P +A P GTS +T K + SE+E
Sbjct: 533 LK----------GKGSPRPQA----------------PKANGTSALTAQNGKAAKNSEEE 566
Query: 622 SKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTK 681
+EK + V ++ SL+ +A K A + P +KK K T + P +
Sbjct: 567 EEEKK-----KAAVVVSKSGSLKKRKQNEAAKEA-------ETPQAKKIKLQTPNTFPKR 614
Query: 682 QK 683
+K
Sbjct: 615 KK 616
Score = 73.2 bits (178), Expect = 8e-13
Identities = 95/425 (22%), Positives = 157/425 (36%), Gaps = 81/425 (19%)
Query: 317 KKAEKKVTS---ETKKKEKEDIKKKSEKETAIDVEKK--EPGKASETKQGTVKIAAQAAA 371
KKA+KK +S E +E+E+++ K+ A+ ++ PGKA AA
Sbjct: 76 KKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKA--------------AA 121
Query: 372 KKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKS-PKKEHSVPSDKQVKAKTE--- 427
K E + + E +Q K Q+ + + AK+ PKK S SD ++ E
Sbjct: 122 KASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPK 181
Query: 428 RAKEEIGAVSIK--KAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPA 485
K +I V++K P K K + S +SS D +EEK A
Sbjct: 182 NQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSD----DSEEEKAAA 237
Query: 486 SLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISE--------- 536
+ K+ P K + ++KA + P + E+ + +++ KP ++
Sbjct: 238 TPKKTVP---KKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPP 294
Query: 537 ---------------KVQIHKQDIVKPEK---TVSHGKPEEKVLKQVKAVTIEKTAKPKP 578
K + KQ V+ + S EE+ KAV + T KP P
Sbjct: 295 PSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPP 354
Query: 579 TKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKES---------------- 622
KKA + + + P + T++ K ++ K
Sbjct: 355 AKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQ 414
Query: 623 ---KEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSP 679
KAD EE S+ +E + + KP +K +PA K+A +G+ D S
Sbjct: 415 KLLTRKADSSSSEEESSSSEEEKTK--KMVATTKPKATAKAALSLPA-KQAPQGSRDSSS 471
Query: 680 TKQKS 684
S
Sbjct: 472 DSDSS 476
Score = 59.3 bits (142), Expect = 1e-08
Identities = 76/344 (22%), Positives = 137/344 (39%), Gaps = 34/344 (9%)
Query: 111 SDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPE---RKIQTKVTHKEK 167
SD SSED+E T K ++P + K ++P +K+ T+
Sbjct: 366 SDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSS 425
Query: 168 EKGKEKVREKEKPEK-------KATHKEKIE--KKEKPETKTLAKEQKKAKTAEKSEEKT 218
+ + E+EK +K KAT K + K+ P+ + + ++E+ EEKT
Sbjct: 426 SEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKT 485
Query: 219 KKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFV 278
K K +KV AA K K + S+ E++
Sbjct: 486 SKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKG---------- 535
Query: 279 HGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSE--TKKKEKEDIK 336
G +P A T Q + S EE+E EKKKA V+ KK+++ +
Sbjct: 536 KGSPRPQAPKANGTSALTAQNGKAAKNS---EEEEEEKKKAAVVVSKSGSLKKRKQNEAA 592
Query: 337 KKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKE-DSKKTKKPAEVEQPKGK 395
K++E A ++ + P + K+G + ++ ++E+ E DS+ + + +G
Sbjct: 593 KEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAK--RGA 650
Query: 396 KQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIK 439
+ E+ + K K + S + K K +R G++S++
Sbjct: 651 AGDWGERANQVLKFTKGK----SFRHEKTKKKRGSYRGGSISVQ 690
Score = 56.2 bits (134), Expect = 1e-07
Identities = 66/310 (21%), Positives = 117/310 (37%), Gaps = 29/310 (9%)
Query: 380 SKKTKKPAEVEQPKGKKQEKKEKHVEPAKS---PKKEHSVPSDKQVKAKTERAKEEIGAV 436
+KK KK A + +E++E PAK P K +P K +E + E
Sbjct: 75 AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSE--ES 132
Query: 437 SIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEK------ 490
S +K++ K V+ + + K+ + D + E++ P + K K
Sbjct: 133 SDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTV 192
Query: 491 EPETKKDEKMSKAGKEV-KPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPE 549
+ +TK K ++A ++ K +E K A + K + K+ +V
Sbjct: 193 KAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKA 252
Query: 550 KTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTE 609
+ P K + + E+ + KP K P PK + GT +
Sbjct: 253 PVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKS-LGTQPPKK 311
Query: 610 SGKKKTEI-SEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASK 668
+ +K+ + S ++S +++D E+K T+ A VSK P +K
Sbjct: 312 AVEKQQPVESSEDSSDESDSSSEEEKKPPTK---------------AVVSKATTKPPPAK 356
Query: 669 KAKEGTEDVS 678
KA E + D S
Sbjct: 357 KAAESSSDSS 366
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 95.5 bits (236), Expect = 2e-19
Identities = 142/631 (22%), Positives = 252/631 (39%), Gaps = 82/631 (12%)
Query: 110 LSDIISSEDEEDDDG--DEDTDKGEIDEPP----LRKKEIHKD--------KTEKQEKPE 155
++DI + E E+D D GE + P L++KE ++ K+ ++ PE
Sbjct: 1115 IADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPE 1174
Query: 156 RKIQTKVTHKEKEKGK------------EKVREKEKPEKKATHKEKIEKKEKPETKTLAK 203
R+ + + K++G EK KEK +K++T K K ++K++ +
Sbjct: 1175 RQKDKEPRDRRKDRGAADAGRDKKEKVFEK--HKEKKDKESTEKYK-DRKDRASVDSTQD 1231
Query: 204 EQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEK---EDKEKAAVSK 260
++ K K EK+E+K E K + K K KE + + S EK E E+ A+ +
Sbjct: 1232 KKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHE 1291
Query: 261 HEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAE 320
+ + D F +PG + + S L EK EK++
Sbjct: 1292 YREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHR 1351
Query: 321 KKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKD--EKKE 378
+S K ++E KK+ EKKE G+ + K+G ++KD + ++
Sbjct: 1352 HSSSSSKKSHDRERAKKEK-------AEKKEKGE--DYKEG--------GSRKDSGQYEK 1394
Query: 379 DSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSI 438
D + K +++ +K +E + KK+ + S+++ K E+ + G+ +I
Sbjct: 1395 DFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKN-DSEREPSKKIEKELKPYGSSAI 1453
Query: 439 KKAVPGKKEEKTTKTVEQEIRKEKSGKTSSIL---KDKEPIKGKEEKVPASL-KEKEPET 494
KK EK + E + + +L +D+ ++E+ PA+ K+ P
Sbjct: 1454 NILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKDSPPRV 1513
Query: 495 KKDEKMSKAGK--EVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTV 552
KD+ + + + K K G ++EK +P ++ K+D EK +
Sbjct: 1514 LKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARPREKLL 1573
Query: 553 SHG----KPEEKVLKQVKAVTIEKTAK-----PKPTKKAEHREREPPSIKTDKPKPTPKG 603
G E++L Q K + IE+ K K +K HR +P +K KP G
Sbjct: 1574 GDGDLMMTSFERMLSQ-KDLEIEERHKRHKERMKQMEKLRHRSGDPK--LKEKAKPADDG 1630
Query: 604 TSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVED 663
+ + KK + K+ K L+E +LH + A+ SKD
Sbjct: 1631 RKKGLDIPAKKPPGLDPPFKD----KKLKESTPIPPAAENKLHPASGAD-----SKDWLA 1681
Query: 664 VPASKK---AKEGTEDVSPTKQKSPISFFQC 691
P K+ A + PT +P S C
Sbjct: 1682 GPHMKEVLPASPRPDQSRPTGVPTPTSVLSC 1712
Score = 80.1 bits (196), Expect = 7e-15
Identities = 132/617 (21%), Positives = 245/617 (39%), Gaps = 92/617 (14%)
Query: 120 EDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEK 179
E +D + +DK + E L + +K K K ++ K KE++ K K+ EKE
Sbjct: 660 EYEDSKQKSDKAILLENDLSTE--NKLKVLKHDRDHFK-------KEEKLSKMKLEEKEW 710
Query: 180 PEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKE 239
K ++I+ K +++ +E+ ++ AEK E++ KE K K+EK++ + K+
Sbjct: 711 LFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEK--ERSLKE-KSPKEEKLRLYKEERKK 767
Query: 240 VQK-TPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQ 298
K PSK ++K D ++ +SK ++K IF K L E+
Sbjct: 768 KSKDRPSKLEKKNDLKEDKISKEKEK-----------IFKEDKEK----------LKKEK 806
Query: 299 ASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASET 358
R A +E + + E + T + ++ D +++ D + ++ + T
Sbjct: 807 VYR---EDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVT 863
Query: 359 KQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKG--------KKQEKKEKHVEPAKSP 410
+K + A + KEDSK+ ++ + + + K ++ +K+ E K
Sbjct: 864 DYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQ 923
Query: 411 KKEH-SVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKE--KSGKTS 467
++H SVP K K R E G K A+ KE + + +E +E K
Sbjct: 924 TEKHKSVPGYLSEKDKKRRESAEAGR-DRKDALESCKERRDGRAKPEEAHREELKECGCE 982
Query: 468 SILKDK---------------EPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPP 512
S KDK P + KE+K KE++ +TK + K+ + K +
Sbjct: 983 SGFKDKSDGDFGKGLEPWERHHPAREKEKK-DGPDKERKEKTKPERYKEKSSDKDKSEKS 1041
Query: 513 QLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEK 572
L+ +++K + KE K + H +D E+ S + +EK K + E
Sbjct: 1042 ILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKD---KERKASLDQGKEKKEKAFPGIISED 1098
Query: 573 TAKPKPTKKAEHREREPPSIKTDKPK-------------------PTPKGTSEVTESGKK 613
++ K KK + + I TD+ + P G E E +
Sbjct: 1099 FSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREA 1158
Query: 614 KTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEG 673
++S +K + ++++ R++ + + +K K E KK KE
Sbjct: 1159 YASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKE-----KKDKES 1213
Query: 674 TEDVSPTKQKSPISFFQ 690
TE K ++ + Q
Sbjct: 1214 TEKYKDRKDRASVDSTQ 1230
Score = 72.8 bits (177), Expect = 1e-12
Identities = 110/475 (23%), Positives = 189/475 (39%), Gaps = 40/475 (8%)
Query: 117 EDEEDDDGDEDTDK-GEIDEPPLRKKEIHKDKTEKQ----EKPERKIQTKVTHKEKEKGK 171
+DE + D D++ D+ +D+ L KK+ K+ K E K TK +K
Sbjct: 344 KDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKAS 403
Query: 172 EKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVK 231
++ E+ A+ +K + T+ +KT E S K +KE K+++ K
Sbjct: 404 HRILSDTSDEEDASVTVGTGEKLRLSAHTILPG---SKTREPSNAKQQKEKNKVKKKRKK 460
Query: 232 QTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFC-------------RYMIDIFV 278
+T + K K E + +++ S + +D +
Sbjct: 461 ETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSA 520
Query: 279 HGDLKPGQSPAIPP-PLPTEQASR-------PTPASPALEEKEGEKKKAEKKVTSETKKK 330
G S A P T+Q ++ T +SPA E ++TSE+
Sbjct: 521 SSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSES-DY 579
Query: 331 EKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTK-KPAEV 389
E +S K E ++ SE K + A A K D++ + KK K K
Sbjct: 580 SSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHK 639
Query: 390 EQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEK 449
+ KG+ +E ++ ++ SDK + + + + E V KKEEK
Sbjct: 640 NKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEK 699
Query: 450 TTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKP 509
+K +E KE K LK IK + + S +E++ + K EK ++ KE P
Sbjct: 700 LSKMKLEE--KEWLFKDEKSLK---RIKDTNKDISRSFREEKDRSNKAEK-ERSLKEKSP 753
Query: 510 KPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQ 564
K +L+ KEE+ + K + +P+ EK K+D + EK + +EK+ K+
Sbjct: 754 KEEKLRLYKEERKK---KSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKLKKE 805
Score = 60.5 bits (145), Expect = 5e-09
Identities = 115/520 (22%), Positives = 200/520 (38%), Gaps = 50/520 (9%)
Query: 111 SDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKG 170
S+ S+E E++D +D E K K + PE + T E E
Sbjct: 292 SEESSTESSEEEDAPSFAPSSSVDGNNT-DSEFEKGLKHKAKNPEPQKATAPVKDEYEFD 350
Query: 171 KEKVREKEKPE------KKATHKE----------KIEKKEKPETKTLAKEQKKAKTAEKS 214
++ +++ P KK KE K+E K + T+A ++ + +
Sbjct: 351 EDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHRILSDT 410
Query: 215 EEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKD----QYAFC 270
++ V G EK++ +A + KT K+ KEK V K +K+ + F
Sbjct: 411 SDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGREVRFG 470
Query: 271 RYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVT----SE 326
+ D F + + S + + +S SP + + T S
Sbjct: 471 K-RSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSS 529
Query: 327 TKKKEKEDIKKKSEKETAIDVEKKEPGKA-SETKQGTVKIAAQAAAKKDEKKEDSK-KTK 384
+K+ + K D K A SE + + ++ D E S ++
Sbjct: 530 AAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESL 589
Query: 385 KPAEVEQPKGKK---QEKKEKHVEPAKS--PKKEHSVPSDKQVKAKTERAKEEIGAVSIK 439
KP Q K+ EKK + A+ PK + K+ K K + +E G SI
Sbjct: 590 KPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSIS 649
Query: 440 KAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEK 499
+ + K + T E E K+KS K +IL + + + KV LK KK+EK
Sbjct: 650 QELKLK-----SFTYEYEDSKQKSDK--AILLENDLSTENKLKV---LKHDRDHFKKEEK 699
Query: 500 MSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKP-AISEKVQIHKQDIVKPEKTVSHGKPE 558
+SK E K K+EK +IK K + S + + + + + E+++ P+
Sbjct: 700 LSKMKLEEKE-----WLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPK 754
Query: 559 EKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPK 598
E+ L+ K +K +K +P+K + + + I +K K
Sbjct: 755 EEKLRLYKEER-KKKSKDRPSKLEKKNDLKEDKISKEKEK 793
Score = 35.0 bits (79), Expect = 0.25
Identities = 49/220 (22%), Positives = 88/220 (40%), Gaps = 27/220 (12%)
Query: 291 PPPLPTEQASRPTPASPALE-EKEGEKK---KAEKKVTSETKKKEKEDIKKKSEKETA-I 345
PP LP +QAS PA LE E GE K E V +ET +E+ S E A +
Sbjct: 2187 PPALPPDQASTRLPAE--LEPEPSGEPKLDVALEAAVEAETVPEERARGDPDSSVEPAPV 2244
Query: 346 DVEKKEPGKASETKQ---------------GTVKIAAQAAAKKDEKKEDSKKTKKPAEVE 390
E++ G + + +A AA ++D++ ++ A E
Sbjct: 2245 PPEQRPLGSGDQGAEAEGPPAASLCAPDGPAPNTVAQAQAADGAGPEDDTEASRAAAPAE 2304
Query: 391 QPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKT 450
P G Q + + A++PK P +++ + R + ++ A K+ P E++
Sbjct: 2305 GPPGGIQPEAAEPKPTAEAPK----APRVEEIPQRMTRNRAQMLANQSKQG-PPPSEKEC 2359
Query: 451 TKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEK 490
T R + G + + P K + ++ L+++
Sbjct: 2360 APTPAPVTRAKARGSEDDDAQAQHPRKRRFQRSTQQLQQQ 2399
Score = 31.2 bits (69), Expect = 3.6
Identities = 32/151 (21%), Positives = 61/151 (40%), Gaps = 15/151 (9%)
Query: 114 ISSEDEEDDDGDEDTDKGEIDEPP-LRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKE 172
+SS+ E G +D DK + + P L + + K+ E+ K + ++K+ E
Sbjct: 17 LSSDMVEKQTGKKDKDKVSLTKTPKLERGDGGKEVRERASKRKLPFTAGANGEQKDSDTE 76
Query: 173 KVREKEKPEKKATHKEKIEKKEK----------PETKTLAKEQKKAKTAEKSEEKTKKEV 222
K + PE+K KE + +K L++ Q+ A + + E++
Sbjct: 77 K----QGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVALLMQMTAEESANSP 132
Query: 223 KGGKQEKVKQTAAKVKEVQKTPSKPKEKEDK 253
+ Q+ K + SK K+K +K
Sbjct: 133 VDTTPKHPSQSTVCQKGTPNSASKTKDKVNK 163
>gi|125656165 THO complex 2 [Homo sapiens]
Length = 1593
Score = 93.2 bits (230), Expect = 8e-19
Identities = 101/420 (24%), Positives = 172/420 (40%), Gaps = 68/420 (16%)
Query: 111 SDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQE------KPERKIQTKVTH 164
S I S + D+ E+TDK + K ++K + + V
Sbjct: 1210 SSSIGSASKSDESSTEETDKSR-ERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKE 1268
Query: 165 KEKEKGKEKVREKEKPEKKATHKEKI---EKKEKPETKTLAKEQKKAKTAEKSEEKTKKE 221
+KEKGKEK +EK++ T + ++ + KEKP+ + K++K +T E++ + K++
Sbjct: 1269 NDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEK 1328
Query: 222 VKGGKQEKVK----QTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIF 277
K K+EK K +T E + T + +EKE + ++K + +
Sbjct: 1329 EKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKEN---------- 1378
Query: 278 VHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKK 337
V G K S ++ P+P P E+E +++K + + K+ + +
Sbjct: 1379 VKGGEKTPVSGSLKSPVPRSDIPEP--------EREQKRRKIDTHPSPSHSSTVKDSLIE 1430
Query: 338 KSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQ 397
E + + P +K E++ D K K E + + KK
Sbjct: 1431 LKESSAKLYINHTPP----------------PLSKSKEREMDKKDLDKSRERSREREKKD 1474
Query: 398 EKKEKHVEPAKSPKKEHSVPSDKQVKAK-TERAKEEIGAVSIKKAVPGKKEEKTTKTVEQ 456
EK K K++HS +D++V T+R KEE G + + K K E
Sbjct: 1475 EKDR------KERKRDHS-NNDREVPPDLTKRRKEENGTMGVSK---HKSESPCESPYPN 1524
Query: 457 EIRKEKSGKTSSILKDKEPIKGKEEKV--------PASLKEKEPETKKDEKMSKAGKEVK 508
E KEK+ K+ S K+K K EK+ S +KE KK+++ S GKE K
Sbjct: 1525 EKDKEKN-KSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEK 1583
Score = 79.0 bits (193), Expect = 1e-14
Identities = 97/409 (23%), Positives = 167/409 (40%), Gaps = 40/409 (9%)
Query: 291 PPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSET-KKKEKEDIKKKSEKETAIDVEK 349
PPP + + P G K+++ T ET K +E+ K+ + + K
Sbjct: 1191 PPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPK 1250
Query: 350 KEPGKASETKQGTV--KIAAQAAAKKDEKKEDSKKTKKPAEVEQPK--GKKQEKKEKHVE 405
G +S G+ K + +K ++KE KK K PA + + GK ++K K
Sbjct: 1251 ---GNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEER 1307
Query: 406 PAKSPK----KEHSVPSDKQVKA--KTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIR 459
P K K KE + SDK+ + K E+AK+E K VP E K+T+ E+E
Sbjct: 1308 PNKDEKARETKERTPKSDKEKEKFKKEEKAKDE----KFKTTVPNA-ESKSTQEREREKE 1362
Query: 460 KEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKE 519
+ + +K KE +KG E K P S K P + D +P+ Q + K +
Sbjct: 1363 PSRERDIAKEMKSKENVKGGE-KTPVSGSLKSPVPRSDIP--------EPEREQKRRKID 1413
Query: 520 EKPEPQIKKEAKPAISE----KVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIE---K 572
P P K ++ E +++ P + ++K L + + + E K
Sbjct: 1414 THPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKK 1473
Query: 573 TAKPKPTKKAEH----REREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADM 628
K + +K +H RE P K K + G S+ ++ ++ KEK
Sbjct: 1474 DEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKS 1533
Query: 629 KHLREEKVSTRKESLQLHNVTK-AEKPARVSKDVEDVPASKKAKEGTED 676
K +EK S +S ++ ++ +K +R K+ + + + G E+
Sbjct: 1534 KSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEE 1582
Score = 45.1 bits (105), Expect = 2e-04
Identities = 43/150 (28%), Positives = 70/150 (46%), Gaps = 11/150 (7%)
Query: 116 SEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQ---EKPERKIQTKVTHKEKEKGKE 172
S++ E D D D + E R+K+ KD+ E++ +R++ +T + KE+
Sbjct: 1450 SKEREMDKKDLDKSRERSRE---REKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGT 1506
Query: 173 KVREKEKPEKKATHKEKIEK-KEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVK 231
K K E EK KEK ++K+ KE K + KS EK K GGK+E +
Sbjct: 1507 MGVSKHKSESPCESPYPNEKDKEKNKSKSSGKE--KGSDSFKS-EKMDKISSGGKKES-R 1562
Query: 232 QTAAKVKEVQKTPSKPKEKEDKEKAAVSKH 261
K+++ +K S ++E K + KH
Sbjct: 1563 HDKEKIEKKEKRDSSGGKEEKKHHKSSDKH 1592
Score = 44.7 bits (104), Expect = 3e-04
Identities = 38/146 (26%), Positives = 63/146 (43%), Gaps = 8/146 (5%)
Query: 125 DEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKA 184
+ + DK ++D+ R +E ++K +++++ ERK +E K R KE+
Sbjct: 1452 EREMDKKDLDKSRERSRE--REKKDEKDRKERKRDHSNNDREVPPDLTK-RRKEENGTMG 1508
Query: 185 THKEKIEKK-EKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKT 243
K K E E P KE+ K+K++ K EK K K +K+ K K
Sbjct: 1509 VSKHKSESPCESPYPNEKDKEKNKSKSSGK--EKGSDSFKSEKMDKISSGGKKESRHDKE 1566
Query: 244 PSKPKEKEDKE--KAAVSKHEQKDQY 267
+ KEK D K H+ D++
Sbjct: 1567 KIEKKEKRDSSGGKEEKKHHKSSDKH 1592
Score = 32.0 bits (71), Expect = 2.1
Identities = 22/71 (30%), Positives = 35/71 (49%), Gaps = 1/71 (1%)
Query: 136 PPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVR-EKEKPEKKATHKEKIEKKE 194
P + KE +K K+ +EK +++ K GK++ R +KEK EKK K+E
Sbjct: 1523 PNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEE 1582
Query: 195 KPETKTLAKEQ 205
K K+ K +
Sbjct: 1583 KKHHKSSDKHR 1593
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 93.2 bits (230), Expect = 8e-19
Identities = 126/556 (22%), Positives = 209/556 (37%), Gaps = 60/556 (10%)
Query: 150 KQEKPERKIQTKVTHKEKEKGKEKVREK-EKPEKKATHKEKIEKKEKPETKTLAKEQ-KK 207
+++ P R + T TH +K + K+ EK P KK + K+ PE+K + +E+ K+
Sbjct: 95 REQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKR 154
Query: 208 AKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQY 267
A+K+ K+ E + K+ K + KT SK ++DK+ SK+ +K
Sbjct: 155 QNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKD---SKNSKKTNT 211
Query: 268 AFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGE------------ 315
F + DLK ++ P + S + + + E
Sbjct: 212 EFLHTKNN--PKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYS 269
Query: 316 ---KKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAK 372
K K T TKK K++ KK S+ E+ + K+ K + K
Sbjct: 270 QNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSK-----------KVKKNVK 318
Query: 373 KDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEE 432
KD+KK+D KK + + E K + K K K KK K K E E
Sbjct: 319 KDDKKKDVKKDTESTDAESGDSKDERKDTK-----KDKKKLKKDDKKKDTKKYPESTDTE 373
Query: 433 IGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEP 492
G A + + + K + K+K K + D E KE +
Sbjct: 374 SG-----DAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSES--------ELESKESQK 420
Query: 493 ETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTV 552
+ KKD+K SK + K + + +P+ KK K K K D K K
Sbjct: 421 DEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKN 480
Query: 553 SHGKPEEK--VLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTES 610
+ E LK+ K + EK K KK ++ E + D+ T TS +
Sbjct: 481 AESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKG 540
Query: 611 GKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKA 670
++E S + K + +++ E L+ +++ R+S + K
Sbjct: 541 SDTESEESLYKPGAKKKIDESDGTSANSKMEGLE------SKRGFRMSSK-KTTFNEKGE 593
Query: 671 KEGTEDVSPTKQKSPI 686
K T V P+++K P+
Sbjct: 594 KASTGRVPPSREKPPL 609
Score = 80.5 bits (197), Expect = 5e-15
Identities = 123/538 (22%), Positives = 210/538 (39%), Gaps = 100/538 (18%)
Query: 138 LRKKEIHKDKTEKQEKPERKIQTKV--THKEKEKGKEKVREKEKPEK-------KATHKE 188
L+K E K K EK P +K K ++ + K+ V EK K + K++H+
Sbjct: 110 LKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHEN 169
Query: 189 KIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKV-----KQTAAKVKEVQKT 243
+ KK K ++T + Q ++ +K KK+ K K+ K K + KT
Sbjct: 170 EQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKT 229
Query: 244 PSKPKEKEDKEKA---------AVSKHEQKDQYAFCR---------YMIDI--FVHGDLK 283
+ P + E + S E + A+ R Y + + D K
Sbjct: 230 SNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTK 289
Query: 284 PGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSET---------------- 327
+ + ++ K+ +KKK KK T T
Sbjct: 290 KNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKK 349
Query: 328 --KKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKK--- 382
KK +K+D KK ++K + E G A + + + + + A+K D+KK+D+KK
Sbjct: 350 DKKKLKKDDKKKDTKKYP--ESTDTESGDAKDARNDSRNL--KKASKNDDKKKDAKKITF 405
Query: 383 -TKKPAEVEQPKGKKQEKKEKHVEPAKSPKK----EHSVPSDKQVKAKTERAKEEIGAVS 437
T +E+E + +K EKK+K + K E S +D + K +++ K
Sbjct: 406 STDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGK------- 458
Query: 438 IKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKD 497
K GKK+ K + + +S + S L+ K+ K +EK S K+ + + +KD
Sbjct: 459 -KDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEK-KGSKKDIKKDARKD 516
Query: 498 --------EKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPE 549
++ SK G + K ++G E E K AK I E +
Sbjct: 517 TESTDAEFDESSKTGFKTSTK---IKGSDTESEESLYKPGAKKKIDES-----------D 562
Query: 550 KTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAE----HREREPPSIKTDKPK-PTPK 602
T ++ K E K+ ++ +KT + +KA RE P + +P P+PK
Sbjct: 563 GTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREKPPLPACEPSLPSPK 620
Score = 63.5 bits (153), Expect = 6e-10
Identities = 94/446 (21%), Positives = 184/446 (41%), Gaps = 59/446 (13%)
Query: 6 AEGNASTTTTVIDSKNGSVPKSPGKVLKRTVTE-DIVTTFSSPAAWLLVIALIITWSAVA 64
++ + T T + +KN +P K LKR+ T D ++ S + + +++ S
Sbjct: 203 SKNSKKTNTEFLHTKN-----NPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDE 257
Query: 65 IVMFD--LVDY-----KNFSASSIAKIGSDPLKLVRDAM----EETTDWIYGFFSLLSDI 113
+ FD L +Y KN+S D K + + E++ D + ++
Sbjct: 258 SINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNV 317
Query: 114 ISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKV----THKEKEK 169
+ ++D D ++ E + +K+ KDK +K +K ++K TK T E
Sbjct: 318 KKDDKKKDVKKDTESTDAESGDSKDERKDTKKDK-KKLKKDDKKKDTKKYPESTDTESGD 376
Query: 170 GKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEK 229
K+ + +K + + +K + +K T ++ + ++K ++K E+K KK+ K ++
Sbjct: 377 AKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKS 436
Query: 230 VK--QTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQS 287
VK + + K SK +K++K+ SK + K + A K +S
Sbjct: 437 VKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDA-------------KKNAES 483
Query: 288 PAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDV 347
+ L ++ + + +EK+G KK +K +T E D + +T
Sbjct: 484 TEMESDLELKKDKKHS------KEKKGSKKDIKKDARKDT---ESTDAEFDESSKTGFKT 534
Query: 348 EKKEPGKASETKQGTVKIAAQAAAKKDE-----KKEDSKKTKKPAEVEQPKGKKQEKKEK 402
K G +E+++ K A+ + + K + ++K+ + K EK EK
Sbjct: 535 STKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEK 594
Query: 403 ----HVEPAKS----PKKEHSVPSDK 420
V P++ P E S+PS K
Sbjct: 595 ASTGRVPPSREKPPLPACEPSLPSPK 620
Score = 62.4 bits (150), Expect = 1e-09
Identities = 109/544 (20%), Positives = 198/544 (36%), Gaps = 55/544 (10%)
Query: 157 KIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKK------AKT 210
K Q VT +K K + E +KP K + + P T A+EQ +KT
Sbjct: 53 KSQITVTRHDKRK----LEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKT 108
Query: 211 -AEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAF 269
+K+E K K+ KGG K K + K P + E+K K
Sbjct: 109 HLKKAEYKKSKDEKGGTPLK-KDSKKKGGSYATNPESKQIVEEKTKR------------- 154
Query: 270 CRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKK 329
Q+ A PL + + + S + E E + + K V+ +
Sbjct: 155 ----------------QNEADKTPLKSSHENEQSKKSKSSSETNPESQNS-KTVSKNCSQ 197
Query: 330 KEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEV 389
K+K+D K + T K P K + + + ++ + E+S V
Sbjct: 198 KDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICS------ENSLNVDFLMLV 251
Query: 390 EQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEK 449
Q + +++ K +S+ K K T++ ++ + + KK+ K
Sbjct: 252 GQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSK 311
Query: 450 TTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKP 509
K ++ K+K K + D E K+E+ K+ + + KKD+K K +
Sbjct: 312 KVKKNVKKDDKKKDVKKDTESTDAESGDSKDER--KDTKKDKKKLKKDDKKKDTKKYPES 369
Query: 510 KPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVT 569
+ K+ + + + K+A +K K ++ K +K K+ K +
Sbjct: 370 TDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDS 429
Query: 570 IEKTAKPKPTKKAEHR---EREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKA 626
KT K K E + EP K KG + + KKK ES E
Sbjct: 430 --KTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEME 487
Query: 627 DMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKSPI 686
L+++K ++++ ++ K + S D E +SK + + + + +S
Sbjct: 488 SDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEE 547
Query: 687 SFFQ 690
S ++
Sbjct: 548 SLYK 551
>gi|58082089 hypothetical protein LOC161394 [Homo sapiens]
Length = 674
Score = 90.5 bits (223), Expect = 5e-18
Identities = 131/590 (22%), Positives = 233/590 (39%), Gaps = 79/590 (13%)
Query: 116 SEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVR 175
+E ED D D D GE++ +HK + K +K+ + ++ + +
Sbjct: 2 AEVPEDYDSGPDED-GELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETE 60
Query: 176 EKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAA 235
E++ E + + ++ K ++ ++ K ++E +EVK +T+
Sbjct: 61 EEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKS-------ETSR 113
Query: 236 KVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLP 295
++ E K P ++ KE E K D+F+ ++ P +PP
Sbjct: 114 EMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTE-----DVFLESAMETDPDP-VPPTET 167
Query: 296 TEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKA 355
+ S T LE E E E V E+ + + E+ + ++T D ++ G++
Sbjct: 168 MSEVSGATVRERNLELLEEE---TEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGES 224
Query: 356 SETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHS 415
E E K KP E+ + + EKK EP + + E
Sbjct: 225 LE-----------------ETDLQPPKMTKPETPEETQRESTEKKR--TEPPEQARLEF- 264
Query: 416 VPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEP 475
++ + ++ EE G ++ P EE K E++ E +T D +P
Sbjct: 265 ------LEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEK-GTELPERTKPDFPDHKP 317
Query: 476 IKGKEEKVPASLKE-----KEPETKK--DEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKK 528
K +E VP L+E E E++K +E + + + +KP+ P+ K EK PQ +
Sbjct: 318 RKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPE 377
Query: 529 EAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHRERE 588
E P + +++ + EKT + KP EK+L+ + KP+ T +E
Sbjct: 378 ETGPVLPQEINPQVE-----EKTQT--KPTEKILE------LPDETKPRETHVEFSKEDR 424
Query: 589 PPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLR--EEKVSTRKESLQ-- 644
P IK+ E E + K +S+K KE + LR EE + T E LQ
Sbjct: 425 PEPIKS--KYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFLQPL 482
Query: 645 --LHNVTK-------AEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKSP 685
L NV++ +E +S+ V + ++E E VS + P
Sbjct: 483 QKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQP 532
Score = 41.2 bits (95), Expect = 0.003
Identities = 70/361 (19%), Positives = 136/361 (37%), Gaps = 34/361 (9%)
Query: 125 DEDTDKGEIDEPPLRKKE----IHKDKTEKQEKPERKIQTKVTHKEKEKGK-EKVREKEK 179
+E+T+ G + E LR + + + KQ+ P K+ + + + K K E+
Sbjct: 185 EEETEPG-VPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEE 243
Query: 180 PEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSE--EKTKKEVKGGKQEKVKQTAAKV 237
++++T K++ E E+ + L KE +K+ E E+T+ EV Q K +
Sbjct: 244 TQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTE 303
Query: 238 KEVQKTPSKPKEKEDK----------EKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQS 287
+ P P K K E+ + E++ + +++ QS
Sbjct: 304 LPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILE----------QS 353
Query: 288 PAIPPPLPTEQASRPTPASPALEEKEGE------KKKAEKKVTSETKKKEKEDIKKKSEK 341
+ P P E +P E+ G + E+K ++ +K E + +
Sbjct: 354 EMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPR 413
Query: 342 ETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKE 401
ET ++ K++ + ++K + K K S K +K + +E
Sbjct: 414 ETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIG 473
Query: 402 KHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKE 461
H E + +K +V + +E E V K+ V +E K + + E + E
Sbjct: 474 THYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPE 533
Query: 462 K 462
K
Sbjct: 534 K 534
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 88.6 bits (218), Expect = 2e-17
Identities = 114/545 (20%), Positives = 246/545 (45%), Gaps = 104/545 (19%)
Query: 130 KGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEK 189
+ +++E L + +++ + EK + E KIQ ++ ++ +EK+RE+E EK +EK
Sbjct: 282 QAQVEENELWNR-LNQQQEEKMWRQEEKIQE--WEEKIQEQEEKIREQE--EKIREQEEK 336
Query: 190 I-----------EKKEKPETKTLAKEQKKAKTAEKSEEKTKK-----EVKGGKQEKVKQT 233
+ EK + E KE+K + E EK +K E+ K+EK+++
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL 396
Query: 234 AAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPP 293
K+ E +K + ++++++EK + ++K Q
Sbjct: 397 EEKMHEQEKIREQEEKRQEEEKI---REQEKRQ--------------------------- 426
Query: 294 LPTEQASRPTPASPALEEKEGEKKKAEKKV-TSETKKKEKEDIKKKSEKETAIDVEKKEP 352
EQ ++ + E+E + ++ EKK+ E K E+E I+++ +++ E++E
Sbjct: 427 ---EQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQ-----EQEEM 478
Query: 353 GKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKK 412
+ E +I Q K++ E +K +K ++ K +QE+K + E ++
Sbjct: 479 WRQEEKIHEQEEIWRQ----KEKMHEQEEKIRK----QEEKVWRQEEKIREQEEKIREQE 530
Query: 413 EHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKD 472
E +++++ + E +EE +K + K E+E R+E+ K + +
Sbjct: 531 EKMWRQEEKIREQEEMWREE------------EKMHEQEKIWEEEKRQEQEDK---MWRQ 575
Query: 473 KEPIKGKEEKV-PASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAK 531
+E I+ +EEKV K +E E K+ E+ K K Q +K + E +I+++ +
Sbjct: 576 EEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWK---------QEEKIREQEEKIQEQEE 626
Query: 532 PAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTA----------KPKPTKK 581
++ +I +Q+ + E+ G+ EEK+ +Q + + ++ + K ++
Sbjct: 627 KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIRE 686
Query: 582 AEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKE 641
E + RE + ++ + + ++ E +K E EK +++ M +E ++ ++E
Sbjct: 687 QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE-QEVRLRQQEE 745
Query: 642 SLQLH 646
+Q H
Sbjct: 746 KMQEH 750
Score = 84.0 bits (206), Expect = 5e-16
Identities = 108/554 (19%), Positives = 261/554 (47%), Gaps = 49/554 (8%)
Query: 142 EIHKDKTEKQEKPER--KIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKE-KPET 198
E++++ +E E+ K+Q K+ E EK + ++ KE K K + +++ + E
Sbjct: 208 ELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEA 267
Query: 199 KTLAKEQKKAKT---AEKSEEKTKKEVKGGKQEKVKQTAAKVKE----VQKTPSKPKEKE 251
L KE + A+ E + + ++EK+ + K++E +Q+ K +E+E
Sbjct: 268 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327
Query: 252 DKEKAAVSKHEQKDQYAF-----CRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPAS 306
+K + K ++++ + R ++ + K + + E+ +
Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE----MMWEKEEKMRRQE 383
Query: 307 PALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIA 366
+ EKE + ++ E+K+ + K +E+E+ K+ E+E + EK++ +A +Q KI
Sbjct: 384 EMMWEKEEKIRELEEKMHEQEKIREQEE--KRQEEEKIREQEKRQEQEAKMWRQEE-KIR 440
Query: 367 AQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKT 426
Q ++++K+ ++ +K E Q K +++EK+++ E + +K H + K K
Sbjct: 441 EQEEKIREQEKKMWRQEEKIHE--QEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKM 498
Query: 427 ERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRK--EKSGKTSSILKDKEPIKGKEEKVP 484
+E+I K+ ++E+ + E++IR+ EK + ++++E + +EEK+
Sbjct: 499 HEQEEKIR----KQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMH 554
Query: 485 ASLK--EKEPETKKDEKMSKAGKEVKPKPPQL----------QGKKEEKPEPQIKKEAK- 531
K E+E ++++KM + ++++ + ++ + K++E+ E K+E K
Sbjct: 555 EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKI 614
Query: 532 PAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPS 591
EK+Q ++ I + E+ + + +E++ ++ + E+ K ++ + E
Sbjct: 615 REQEEKIQEQEEKIREQEEKI---REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMW 671
Query: 592 IKTDKPKPTPKGTSEVTESGKKKTEISEKESK---EKADMKHLREEKVSTRKESLQLHNV 648
+ +K + K E E +++ E+ +++ + E+ + +EEK+ ++E ++
Sbjct: 672 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 731
Query: 649 TKAEKPARVSKDVE 662
E+ R+ + E
Sbjct: 732 KMWEQEVRLRQQEE 745
Score = 78.2 bits (191), Expect = 3e-14
Identities = 88/446 (19%), Positives = 226/446 (50%), Gaps = 36/446 (8%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVRE 176
+++E+ +++ E +E R++E+ +K EK + E + K +EK + +E++
Sbjct: 317 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK---EEKMRRQEEMMW 373
Query: 177 KEKPEKKATHKEKIEKKEKP--ETKTLAKEQKKAKTAE-KSEEKTK---------KEVKG 224
EK EK +E + +KE+ E + EQ+K + E K +E+ K +E K
Sbjct: 374 -EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 432
Query: 225 GKQ-EKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDL- 282
+Q EK+++ K++E +K + +EK +++ + ++++Q R I ++
Sbjct: 433 WRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIW 492
Query: 283 KPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKV-TSETKKKEKEDIKKKSEK 341
+ + +Q + + E+E + ++ E+K+ E K +E+E++ ++ EK
Sbjct: 493 RQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEK 552
Query: 342 ETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKE 401
E+++ + + ++ K+ Q ++++++ ++ +K E E+ + +++EK
Sbjct: 553 MH----EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMW 608
Query: 402 KHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKE 461
K E + ++E +++++ + E+ +E+ ++ G++EE K EQE + +
Sbjct: 609 KQEEKIRE-QEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEE---KMCEQEEKMQ 664
Query: 462 KSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEK 521
+ +T + + +E I+ +E+K+ +E+E + ++ E+M + +E + + ++EEK
Sbjct: 665 EQEET--MWRQEEKIREQEKKI----REQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 718
Query: 522 ---PEPQIKKEAKPAISEKVQIHKQD 544
E +++++ + ++V++ +Q+
Sbjct: 719 MQEQEEKMRRQEEKMWEQEVRLRQQE 744
Score = 48.9 bits (115), Expect = 2e-05
Identities = 71/366 (19%), Positives = 159/366 (43%), Gaps = 78/366 (21%)
Query: 308 ALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAA 367
AL +KKKA++ + TK E++ + + + T D E KE
Sbjct: 180 ALSAVATQKKKADRYIEELTK--ERDALSLELYRNTITDEELKEKN-------------- 223
Query: 368 QAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTE 427
AK EK + + K ++ + K++ ++ K + P +Q++A+ +
Sbjct: 224 ---AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP------------QQQLQAEAD 268
Query: 428 RAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASL 487
+E+ +VS K ++ E + +Q+ K + + +E I+ EEK+
Sbjct: 269 HLGKELQSVSAKLQAQVEENELWNRLNQQQEEK--------MWRQEEKIQEWEEKI---- 316
Query: 488 KEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVK 547
+E+E + ++ E+ + +E + ++ +KEEK Q E++ K++ ++
Sbjct: 317 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ----------EEMMWEKEEKMR 366
Query: 548 PEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEV 607
++ + K EEK+ +Q + + K + ++ E + E I+ E
Sbjct: 367 RQEEMMWEK-EEKMRRQEEMMW----EKEEKIRELEEKMHEQEKIR------------EQ 409
Query: 608 TESGKKKTEISEKESKEKADMKHLR-EEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPA 666
E +++ +I E+E +++ + K R EEK+ ++E ++ E+ ++ + E +
Sbjct: 410 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR-------EQEKKMWRQEEKIHE 462
Query: 667 SKKAKE 672
+K +E
Sbjct: 463 QEKIRE 468
Score = 46.6 bits (109), Expect = 8e-05
Identities = 31/158 (19%), Positives = 86/158 (54%), Gaps = 14/158 (8%)
Query: 119 EEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKE 178
E+++ E +K E +R++E +K ++QE+ R+ + K+ +E+ +++ + E
Sbjct: 595 EQEEKRQEQEEKMWKQEEKIREQE---EKIQEQEEKIREQEEKIREQEEMTQEQEEKMGE 651
Query: 179 KPEKKATHKEKIEKKE----------KPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQE 228
+ EK +EK++++E + + K + ++++K + E+ ++ ++E ++E
Sbjct: 652 QEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQE-QEEKMWEQEE 710
Query: 229 KVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQ 266
K+ + K++E ++ + +EK +++ + + E+K Q
Sbjct: 711 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Score = 40.8 bits (94), Expect = 0.005
Identities = 33/130 (25%), Positives = 71/130 (54%), Gaps = 9/130 (6%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVRE 176
+++E+ +++ E +E ++E ++ EK + E K+Q + + + +EK+RE
Sbjct: 622 QEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ--EETMWRQEEKIRE 679
Query: 177 KEKP--EKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKK----EVKGGKQE-K 229
+EK E++ +E+ E ++ E K +E+K + EK +E+ +K E K +QE +
Sbjct: 680 QEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVR 739
Query: 230 VKQTAAKVKE 239
++Q K++E
Sbjct: 740 LRQQEEKMQE 749
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 88.6 bits (218), Expect = 2e-17
Identities = 109/546 (19%), Positives = 251/546 (45%), Gaps = 48/546 (8%)
Query: 127 DTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATH 186
+++K EI L KE+ K K E+ + ++QT +E + +E++RE+EK +K
Sbjct: 238 ESEKSEIQ---LNVKEL-KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
Query: 187 K-----EKIEKKE---KPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVK 238
K E++ ++E + + + + +++K+ + EK + +KE++ K+ + ++ + +
Sbjct: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQ 353
Query: 239 EVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQ 298
E + + K +E +EK + +Q R + Q EQ
Sbjct: 354 EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR-----------EQEQKMRDQEERMWEQ 402
Query: 299 ASRPTPASPALEEKEG-----EKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPG 353
R + E+E EK + EKK+ E +KK ++ +K E+E + EKK
Sbjct: 403 DERLREKEERMREQEKMWEQVEKMREEKKM-QEQEKKTRDQEEKMQEEERIREREKKMRE 461
Query: 354 KASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQ--PKGKKQEKKEKHVEPAKSPK 411
+ ++ K+ Q ++++++ ++ + P + E+ + K QE++EK E + +
Sbjct: 462 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR 521
Query: 412 KEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEK--------TTKTVEQEIR---K 460
+ + ++ + E+ +E+ + ++ +E+K KT EQE + +
Sbjct: 522 DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQ 581
Query: 461 EKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKE- 519
E+ + ++++E +EE++ +EK E ++EKM + +++ + ++Q ++E
Sbjct: 582 EEKMREEERMREREKKMREEEEMMREQEEKMQE--QEEKMQEQEEKMWEQEEKMQEQEEK 639
Query: 520 --EKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPK 577
E+ E ++E K +++ K+ + + EK K +E+ K + +EK + +
Sbjct: 640 MWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQ 699
Query: 578 PTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVS 637
K + + ++ K + + E +K E EK +++ +M +EEK+
Sbjct: 700 EKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWE-QEEKMW 758
Query: 638 TRKESL 643
++E +
Sbjct: 759 EQEEKM 764
Score = 85.1 bits (209), Expect = 2e-16
Identities = 103/539 (19%), Positives = 246/539 (45%), Gaps = 59/539 (10%)
Query: 119 EEDDDGDEDTDKGEIDEPPLRKKEI----HKDKTEKQEKPERKIQTKVTHKEKEKGKEKV 174
E+++ E +K E +R++E +++ +QEK R+ + K+ +E+ ++
Sbjct: 345 EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDE 404
Query: 175 REKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTA 234
R +EK E+ ++ E+ EK + +EQ+K KT ++ EEK ++E E++++
Sbjct: 405 RLREKEERMREQEKMWEQVEKMREEKKMQEQEK-KTRDQ-EEKMQEE------ERIRERE 456
Query: 235 AKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPL 294
K++E ++T + +EK K++ + + E+K+
Sbjct: 457 KKMREEEETMREQEEKMQKQEENMWEQEEKEW---------------------------- 488
Query: 295 PTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDI----KKKSEKETAIDVEKK 350
Q R L E+E +++ EK E K +++E++ KK +E + E +
Sbjct: 489 ---QQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQ 545
Query: 351 EPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEV--EQPKGKKQEKKEKHVEPAK 408
+ + + K+ Q + + +E KKT E E+ + +++EKK + E
Sbjct: 546 MWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMM 605
Query: 409 SPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSS 468
++E +++++ + E+ E+ + ++ ++EEK + E+ +++ +
Sbjct: 606 REQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKE 665
Query: 469 ILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKP----EP 524
L + E ++ +E+ ++E+E + + EKM K +E + K + +EE+ E
Sbjct: 666 KLWEHEKMQEQEK-----MQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK 720
Query: 525 QIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEH 584
++++E + ++ ++ +Q+ E+ + EEK+ +Q + + E+ P+ +K
Sbjct: 721 KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMW-EQQRLPEQKEKLWE 779
Query: 585 REREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESL 643
E+ K + + + E ++K E++ + + + +EEK+ ++E +
Sbjct: 780 HEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKM 838
Score = 84.3 bits (207), Expect = 4e-16
Identities = 105/538 (19%), Positives = 253/538 (47%), Gaps = 52/538 (9%)
Query: 118 DEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREK 177
++E D++ E DE LR+KE ++ +QEK +++ K+ ++ ++K R++
Sbjct: 387 EQEQKMRDQEERMWEQDER-LREKE---ERMREQEKMWEQVEKMREEKKMQEQEKKTRDQ 442
Query: 178 EKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKG--GKQEKVKQTAA 235
E+ K +E+I ++EK K +++ +T + EEK +K+ + ++EK Q
Sbjct: 443 EE---KMQEEERIREREK-------KMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR 492
Query: 236 KVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLP 295
++ +K + K +E +EK + + +DQ ++ ++ +
Sbjct: 493 LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE--------- 543
Query: 296 TEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKA 355
+Q E+K ++++ +K T E +KK + +K E+E + EKK +
Sbjct: 544 -DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE 602
Query: 356 SETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEK----KEKHVEPAKSPK 411
++ K+ Q ++++++ ++ +K E E+ +++EK +EK E + P+
Sbjct: 603 EMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPE 662
Query: 412 KEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQE-IRKEKSGKTSSIL 470
++ + ++++ + E+ +E+ + ++ + K +E+ KT +QE +R+E+S +
Sbjct: 663 QKEKLWEHEKMQ-EQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEES------M 715
Query: 471 KDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEA 530
+++E +EE++ +EK E ++EKM + +E+ + ++ ++E+ E Q E
Sbjct: 716 REREKKMREEEEMMREQEEKMQE--QEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQ 773
Query: 531 KPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHRER--- 587
K + E ++ +Q+ + ++ + E+ ++ K E+ + + K E+
Sbjct: 774 KEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWG 833
Query: 588 ---------EPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKV 636
E + +K + +G E ++K E++ +E+ + +EEK+
Sbjct: 834 QEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
Score = 79.3 bits (194), Expect = 1e-14
Identities = 89/435 (20%), Positives = 216/435 (49%), Gaps = 34/435 (7%)
Query: 112 DIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEK---PERKI---QTKVTHK 165
+ + ++E+ +E+ + E E ++ K+K +QEK E KI + K+ +
Sbjct: 464 ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 523
Query: 166 EKEKGKEKV--REKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKT-KKEV 222
E+ G+EK R+++ E++ E+ EK E K +E++ K ++ E+KT +E
Sbjct: 524 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE 583
Query: 223 KGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQK---------DQYAFCRYM 273
K ++E++++ K++E ++ + +EK +++ + + E+K +Q
Sbjct: 584 KMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQ 643
Query: 274 IDIFVHGDLKPGQSPAIP---PPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKK 330
+ + K + +P L + + EEK E++K EKK ++ ++K
Sbjct: 644 EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKK--TQEQEK 701
Query: 331 EKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVE 390
+ D +K E+E+ + EKK + ++ K+ Q +++++E ++ +K E E
Sbjct: 702 KTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQE 761
Query: 391 QPKGKKQ---EKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKE 447
+ ++Q E+KEK E K ++E +++++ + E+ + + ++ + G++E
Sbjct: 762 EKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQ------EEKMRGQEE 815
Query: 448 EKTTKTVEQEIRKEKS-GKTSSILKDKEPIKGKEEKVPASLK-EKEPETKKDEKMSKAGK 505
+ + + ++EK G+ + +E + G+EEK+ ++ ++E +++EKM +
Sbjct: 816 KMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEE 875
Query: 506 EVKPKPPQLQGKKEE 520
+++ + +++G++E+
Sbjct: 876 KMREQEEKMRGQEEK 890
Score = 69.7 bits (169), Expect = 9e-12
Identities = 109/550 (19%), Positives = 243/550 (44%), Gaps = 50/550 (9%)
Query: 150 KQEKPERKIQTKVTHKEK---EKGKEKVREKEKPEKKATHKEK--IEKKEKPETKTLAKE 204
+ +K +R I+ ++ E + + +E +K A +EK + + EK E + KE
Sbjct: 191 RHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKE 250
Query: 205 QKK-----------AKTAEKSEEKTKKEVKGGKQE-KVKQTAAKV--KEVQKTPSKPKEK 250
K+ +T EE ++E + +QE K+++ K+ +E + + K +
Sbjct: 251 LKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMR 310
Query: 251 EDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALE 310
E +EK + ++Q R +L+ + EQ + +
Sbjct: 311 EQEEKMWRQEKRLREQEKELREQ-----EKELREQKELREQEEQMQEQEEKMWEQEEKMR 365
Query: 311 EKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAA 370
E+E + + E+++ + K+ +++ K + ++E + +++ K E + K+ Q
Sbjct: 366 EQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK-EERMREQEKMWEQVE 424
Query: 371 AKKDEKK--EDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTER 428
++EKK E KKT+ E Q + + +E +EK + + +E KQ + E+
Sbjct: 425 KMREEKKMQEQEKKTRDQEEKMQEEERIRE-REKKMREEEETMREQEEKMQKQEENMWEQ 483
Query: 429 AKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLK 488
++E ++ +P +KE+ + QE ++EK + ++D+E + G+E+K+ K
Sbjct: 484 EEKEWQ----QQRLPEQKEKLWEQEKMQE-QEEKIWEQEEKIRDQEEMWGQEKKMWRQEK 538
Query: 489 EKEPET---KKDEKMSKA------GKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQ 539
+E E +++EKM +E K Q Q KK E ++++E + EK
Sbjct: 539 MREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKM 598
Query: 540 IHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHRER---EPPSIKTDK 596
++++++ ++ + E+ ++ K E+ + + K E E+ + + +
Sbjct: 599 REEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQ 658
Query: 597 PKPTPKGTSEVTESGKKKTEISEKESK----EKADMKHLREEKVSTRKESL-QLHNVTKA 651
P K E +++ ++ E+E K EK + K +EK + +E + + ++ +
Sbjct: 659 RLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRER 718
Query: 652 EKPARVSKDV 661
EK R +++
Sbjct: 719 EKKMREEEEM 728
Score = 63.2 bits (152), Expect = 8e-10
Identities = 71/393 (18%), Positives = 180/393 (45%), Gaps = 26/393 (6%)
Query: 315 EKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKD 374
E + E+++ + KK K++ K ++E +++ GK E ++ + + ++
Sbjct: 273 EMWRQEEELREQEKKIRKQEEKMWRQEERL----REQEGKMREQEEKMWRQEKRLREQEK 328
Query: 375 EKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPK---------KEHSVPSDKQVKAK 425
E +E K+ ++ E+ + + + QE++EK E + + +E +KQ++ +
Sbjct: 329 ELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ 388
Query: 426 TERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPA 485
++ +++ + + +KEE+ + + + EK + + + ++ + +EEK+
Sbjct: 389 EQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQE 448
Query: 486 S--LKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKP-EPQIKKEAKPAI--SEKVQI 540
++E+E + +++E+ + +E K + ++EEK + Q E K + EK+Q
Sbjct: 449 EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE 508
Query: 541 HKQDIVKPEKTVSHGK----PEEKVLKQVKAVTIEKTAKPKPTKKAEHRER--EPPSIKT 594
++ I + E+ + + E+K+ +Q K E + K + ++ +
Sbjct: 509 QEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERME 568
Query: 595 DKPKPTPKGTSEVTESGKKKTEISEKESK--EKADMKHLREEKVSTRKESLQLHNVTKAE 652
K + K T + E +++ + E+E K E+ +M +EEK+ ++E +Q E
Sbjct: 569 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWE 628
Query: 653 KPARVSKDVEDVPASKKAKEGTEDVSPTKQKSP 685
+ ++ + E + ++ E+ +Q+ P
Sbjct: 629 QEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
Score = 60.5 bits (145), Expect = 5e-09
Identities = 60/305 (19%), Positives = 143/305 (46%), Gaps = 24/305 (7%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKI---QTKVTHKEKEKGKEK 173
+++E+ +++ E +E ++E ++ EK + E K+ Q KEK EK
Sbjct: 613 QEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK 672
Query: 174 VREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQT 233
++E+EK +++ +EKI ++EK E KT +E+K + EE++ +E +++K+++
Sbjct: 673 MQEQEKMQEQ---EEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRE----REKKMREE 725
Query: 234 AAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPP 293
++E ++ + +EK +++ + + E+K + K + +P
Sbjct: 726 EEMMREQEEKMQEQEEKMQEQEEEMWEQEEK------------MWEQEEKMWEQQRLPEQ 773
Query: 294 LPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPG 353
+ E+E + + E+K+ + +K ++ K + ++E E+K G
Sbjct: 774 KEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWG 833
Query: 354 KASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKE 413
+ + K+ Q +K E+K ++ K + E+ +G++++ +E+ + +K
Sbjct: 834 QEEKMWGQEEKMWGQ--EEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
Query: 414 HSVPS 418
+ V S
Sbjct: 892 YCVGS 896
Score = 59.3 bits (142), Expect = 1e-08
Identities = 74/370 (20%), Positives = 164/370 (44%), Gaps = 45/370 (12%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVRE 176
E+ + E K E +R++E +++ +K + E ++ + ++++ K + +E
Sbjct: 564 EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 623
Query: 177 KEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTK--KEVKGGKQEKVKQTA 234
++ E++ +E+ EK + E K +E+K + E+K K + K +QEK+++
Sbjct: 624 EKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQE 683
Query: 235 AKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPL 294
K+ E +K K +E+E K E++ + M + +
Sbjct: 684 EKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMRE---------------EEEM 728
Query: 295 PTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGK 354
EQ + ++E+E E + E+K+ E ++K E + +KE + EK
Sbjct: 729 MREQEEKMQEQEEKMQEQEEEMWEQEEKMW-EQEEKMWEQQRLPEQKEKLWEHEK----- 782
Query: 355 ASETKQGTVKIAAQAAAKKD-EKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKE 413
Q KI Q +D E+K ++ K + E+ +G QE+K E ++E
Sbjct: 783 ----MQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRG--QEEKMWGQEEKMWGQEE 836
Query: 414 HSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDK 473
++++ + E+ +E++ + +E+ + E+++R G+ + + +
Sbjct: 837 KMWGQEEKMWGQEEKMEEKM-----------QGQEEKMREQEEKMR----GQEEKMREQE 881
Query: 474 EPIKGKEEKV 483
E ++G+EEK+
Sbjct: 882 EKMRGQEEKI 891
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 86.3 bits (212), Expect = 9e-17
Identities = 100/531 (18%), Positives = 254/531 (47%), Gaps = 33/531 (6%)
Query: 127 DTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATH 186
+++K EI L KE+ K K E+ + ++QT +E + +E++RE+EK +K
Sbjct: 200 ESEKSEIQ---LNVKEL-KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 255
Query: 187 KE-KIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPS 245
K + E++ + + + ++++K + EK + +KE++ +QEK + K++E ++
Sbjct: 256 KMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELR--EQEKELREQKKLREQEEQMQ 313
Query: 246 KPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPA 305
+ +EK +++ + + E+K R ++ Q + +Q R
Sbjct: 314 EQEEKMWEQEEKMREQEEK----MWRQEERLWEQEKQMREQEQKM-----RDQEERMWEQ 364
Query: 306 SPALEEKEGEKKKAEKKVTSETKKKEKEDI-----KKKSEKETAIDVEKKEPGKASETKQ 360
L EKE ++ EK E K +E+E I K + E+ET + E+K + +
Sbjct: 365 DERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424
Query: 361 GTVKIAAQAAAKKDEKK--EDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPS 418
K Q + ++K E K ++ ++ + + K ++++E + K ++E
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484
Query: 419 DKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKG 478
+ Q+ + E+ +++ + ++ +++E+ + E+ ++K + +++++ +
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQE 544
Query: 479 KEEKV---PASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAIS 535
+E+K ++E+E ++++KM + + ++ + ++Q ++E+ E + K +
Sbjct: 545 QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQ---E 601
Query: 536 EKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKK---AEHREREPPSI 592
EK+Q ++ + + E+ + + E+K+ +Q + + ++ + +K E + RE
Sbjct: 602 EKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEE- 660
Query: 593 KTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESL 643
K + + +G E ++K + E++ +E+ + +EEK+ ++E +
Sbjct: 661 KMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKM 711
Score = 85.9 bits (211), Expect = 1e-16
Identities = 95/444 (21%), Positives = 211/444 (47%), Gaps = 60/444 (13%)
Query: 118 DEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREK 177
D+E+ ++D LR+KE + EK + E K+Q + +E+EK K+RE+
Sbjct: 356 DQEERMWEQD--------ERLREKEERMREQEKMWEQEEKMQEEERIREREK---KMREE 404
Query: 178 EKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKV 237
E E +EK++K+E+ + KE ++ + E+ E+ ++E ++EK+ + K+
Sbjct: 405 E--ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 462
Query: 238 KEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTE 297
++ ++ + K+ +EK EQ+DQ ++ + Q + +
Sbjct: 463 RDQEEMWGQEKKMWRQEK----MREQEDQ---------MWEQEEKMRDQEQKM-----WD 504
Query: 298 QASRPTPASPALEEKE-----------GEKKKAEKKVTSETKKKEKEDIKKKSEKETAID 346
Q R L EKE E+K E+K T E +KK + +K E+E +
Sbjct: 505 QEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRE 564
Query: 347 VEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEP 406
EKK + ++ K+ Q ++++++ ++ +K E E+ +++EK + E
Sbjct: 565 REKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEE 624
Query: 407 AKSPKKEHSV-PSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGK 465
K ++E + +++++ + E+ E+ K E+ K EQE ++ G+
Sbjct: 625 DKMQEQEEMMWEQEEKMQEQEEKMWEQ----------EEKMREQEEKMREQE--EKMQGQ 672
Query: 466 TSSILKDKEPIKGKEEKVPASLKEKEPETK-KDEKMSKAGKEVKPKPPQLQGKKEEKPEP 524
+ + +E ++G+EEK ++E+E + + ++EKM +++ + ++ G++E + +
Sbjct: 673 EEKMREQEEKMQGQEEK----MREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKE 728
Query: 525 QIKKEAKPAISEKVQIHKQDIVKP 548
+ ++ K + E++ H++ +P
Sbjct: 729 ERIRDQKEKMQERLPEHEERCSEP 752
Score = 70.5 bits (171), Expect = 5e-12
Identities = 98/521 (18%), Positives = 235/521 (45%), Gaps = 76/521 (14%)
Query: 152 EKPERKIQTKVTHKEK---EKGKEKVREKEKPEKKATHKEKIE--KKEKPETKTLAKEQK 206
+K +R I+ ++ E + + +E +K A +EK+ + EK E + KE K
Sbjct: 155 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELK 214
Query: 207 KAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQ 266
+ E+++ + QE++ + +++E +K K +EK +++ + + E K +
Sbjct: 215 RK--LERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMR 272
Query: 267 YAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSE 326
EQ + L E+E E ++ EK++ +
Sbjct: 273 ------------------------------EQEEKMRRQEKRLREQEKELREQEKELREQ 302
Query: 327 TKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKP 386
K +E+E+ ++ E++ E++E + E K + K+ ++E + ++
Sbjct: 303 KKLREQEEQMQEQEEKMW---EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 359
Query: 387 AEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKK 446
EQ + + +EK+E+ E K ++E + +++++ + ++ +EE + ++ K+
Sbjct: 360 RMWEQDE-RLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ 418
Query: 447 EEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKE 506
EE + E+E ++++ + L ++E ++ +EEK+ E+E + + E+M G+E
Sbjct: 419 EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI----WEQEEKIRDQEEMW--GQE 472
Query: 507 VKPKPPQLQGKKEEK---PEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLK 563
K + ++E++ E +++ + + ++ ++ +QD EK EE++ +
Sbjct: 473 KKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREK-------EERMRE 525
Query: 564 QVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESK 623
Q K E+ K + KK + +E++ T + E +++ + E+E K
Sbjct: 526 QKKMWQQEE--KMREEKKTQEQEKK---------------TWDQEEKMREEERMREREKK 568
Query: 624 --EKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVE 662
E+ +M +EEK+ ++E ++ E+ ++ + E
Sbjct: 569 MREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEE 609
Score = 68.9 bits (167), Expect = 2e-11
Identities = 84/432 (19%), Positives = 198/432 (45%), Gaps = 71/432 (16%)
Query: 119 EEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKI----QTKVTHKEKE--KGKE 172
EE++ E +K + E + ++E + + ++Q PE+K Q K+ +E++ + +E
Sbjct: 403 EEEETMREQEEKMQKQEENMWEQE--EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 460
Query: 173 KVREKEK---PEKKATHKEKIEKKE----KPETKTLAKEQK----KAKTAEKSEEKTKKE 221
K+R++E+ EKK +EK+ ++E + E K +EQK + + E+ E +KE
Sbjct: 461 KIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKE 520
Query: 222 VKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGD 281
+ +Q+K+ Q K++E +KT + K+ D+E+ + +++ R
Sbjct: 521 ERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMR---------- 570
Query: 282 LKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEK 341
E+ ++E+E + ++ E+K+ + +K ++++ K ++
Sbjct: 571 ---------------EEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQE 615
Query: 342 ETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKE 401
E + E+++ K+ Q +++++ ++ +K E E+ K ++QE+K
Sbjct: 616 EKMWEQEEED------------KMQEQEEMMWEQEEKMQEQEEKMWEQEE-KMREQEEKM 662
Query: 402 KHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKE 461
+ E ++E +++++ + E+ +E+ ++ + G++E+ + + ++E
Sbjct: 663 REQEEKMQGQEEKMREQEEKMQGQEEKMREQ------EEKMRGQEEKMWGQEEKMWGQEE 716
Query: 462 KSGKTSSILKDKEPIKGKEEKVPASLKEKE--------PETKKDEKMSKAGKEVKPKPPQ 513
K + + +E I+ ++EK+ L E E P +K MS G
Sbjct: 717 KMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCLPPSKVLCNMSHTGSVEPAGGEA 776
Query: 514 LQGKKEEKPEPQ 525
+G ++ P Q
Sbjct: 777 GEGSPQDNPTAQ 788
Score = 58.2 bits (139), Expect = 3e-08
Identities = 59/301 (19%), Positives = 136/301 (45%), Gaps = 45/301 (14%)
Query: 118 DEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEK---GKEKV 174
D+E D++ E DE K+E +++ + ++ E+ + K T ++++K +EK+
Sbjct: 497 DQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKM 556
Query: 175 REKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTA 234
RE+E+ ++ EKK + E + + ++++K + E+ E+ ++E K +QE+ Q
Sbjct: 557 REEERMRER-------EKKMREEEEMMREQEEKMQ--EQEEKMREQEEKMWEQEEKMQEQ 607
Query: 235 AKVKEVQKTPSKPKEKEDK---EKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIP 291
+ Q+ +E+EDK ++ + + E+K Q
Sbjct: 608 EEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQ------------------------- 642
Query: 292 PPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKE 351
EQ + + E+E + ++ E+K+ + +K +++ K + ++E + E+K
Sbjct: 643 -----EQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKM 697
Query: 352 PGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPK 411
G+ + K+ Q +++ K+ + + E+ + + E +E+ EP P
Sbjct: 698 RGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCLPPS 757
Query: 412 K 412
K
Sbjct: 758 K 758
Score = 51.6 bits (122), Expect = 3e-06
Identities = 84/413 (20%), Positives = 179/413 (43%), Gaps = 63/413 (15%)
Query: 303 TPASPALEEKEGEKKKAEKKVTSETKKKEKEDIK------KKSEKETAI----DVEKK-E 351
T S E EKK + + + ++ E +D +K+E ETA+ D +K E
Sbjct: 60 TTTSEGCHSPEDEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 119
Query: 352 PGKASETKQ------------GTVKIAAQAAA----KKDEKKEDSKKTKKPAEVEQPKGK 395
G E+K G ++ A A + K D E+ K + +E +
Sbjct: 120 DGNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNT 179
Query: 396 --KQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKT 453
+E K+K+ E + + S S+ Q+ K + K E + + +E+ +
Sbjct: 180 ITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ 239
Query: 454 VEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKK-DEKMSKAGKEVKPKPP 512
E+E+R+++ I K +E + +EE+ L+E+E + ++ +EKM + K ++ +
Sbjct: 240 -EEELREQEK----KIRKQEEKMWRQEER----LREQEGKMREQEEKMRRQEKRLREQEK 290
Query: 513 QLQGKKEEKPEPQIKKEAKPAISEKVQ-IHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIE 571
+L+ +++E E + +E + + E+ + + +Q+ E+ + EE++ +Q E
Sbjct: 291 ELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ------E 344
Query: 572 KTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTE-ISEKESKEKADMKH 630
K + + K + ER E E ++K E + E+E + + K
Sbjct: 345 KQMREQEQKMRDQEER----------------MWEQDERLREKEERMREQEKMWEQEEKM 388
Query: 631 LREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQK 683
EE++ R++ ++ T E+ ++ K E++ ++ + + + K+K
Sbjct: 389 QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK 441
Score = 45.8 bits (107), Expect = 1e-04
Identities = 32/148 (21%), Positives = 81/148 (54%), Gaps = 6/148 (4%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVRE 176
E ++ ++ +K D+ ++E + EK+ + E ++ + K +E+ +EK+RE
Sbjct: 534 EKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ-EEKMRE 592
Query: 177 KEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAK 236
+E EK +EK++++E+ K +E+K + E+ + + ++E+ ++EK+++ K
Sbjct: 593 QE--EKMWEQEEKMQEQEE---KMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEK 647
Query: 237 VKEVQKTPSKPKEKEDKEKAAVSKHEQK 264
+ E ++ + +EK +++ + E+K
Sbjct: 648 MWEQEEKMREQEEKMREQEEKMQGQEEK 675
Score = 44.7 bits (104), Expect = 3e-04
Identities = 32/155 (20%), Positives = 87/155 (56%), Gaps = 7/155 (4%)
Query: 116 SEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPER--KIQTKVTHKEKEKGKEK 173
++++E D++ E + R+K++ +++ +E+ E+ + + K+ +E++ +++
Sbjct: 542 TQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQE 601
Query: 174 VREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQT 233
+ +E+ EK +EK+ ++E+ E K +E+ + EK +E+ +K + ++EK+++
Sbjct: 602 EKMQEQEEKMWEQEEKMWEQEE-EDKMQEQEEMMWEQEEKMQEQEEKMWE--QEEKMREQ 658
Query: 234 AAKVKEVQKTPSKPKEK--EDKEKAAVSKHEQKDQ 266
K++E ++ +EK E +EK + + ++Q
Sbjct: 659 EEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQ 693
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 85.1 bits (209), Expect = 2e-16
Identities = 117/575 (20%), Positives = 222/575 (38%), Gaps = 92/575 (16%)
Query: 143 IHKDKTEKQEKPERKIQTKVTHK--EKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKT 200
I K K +K+EK K + + + + + + + ++ +EK +K++K K
Sbjct: 178 IPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKN 237
Query: 201 LAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEV----------QKTPSKPKEK 250
K +K+ K +KS++ E + E Q+ + +E+ +K+P K EK
Sbjct: 238 SRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEK 297
Query: 251 EDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPP--LPTEQASRPTPASPA 308
E K+ ++++ C P PA L T + P
Sbjct: 298 E-------RKNRERERERECN-----------PPNSQPASYQRRLLVTRSGRKIKGRGPR 339
Query: 309 LEEKEGEKKKAEKKVTSETKKKEKEDIKKK-----SEKETAIDVEKKEPGKASETKQGTV 363
+ ++ SET ++++++ S E I +K E + E ++ V
Sbjct: 340 RYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPV 399
Query: 364 KIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKE-----HSVPS 418
++ K+ K D + E P K + KEK V+ KS KE +S
Sbjct: 400 RV-------KERKITDHRNVS-----ESPNRKNE--KEKKVKDHKSNSKERDIRRNSEKD 445
Query: 419 DKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKG 478
DK +RAK + + S +K+ +++ K + E+ +R G+ +K+
Sbjct: 446 DKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKE------ 499
Query: 479 KEEKVPASLKEKEPETK-KDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEK 537
KEK+ ++K KD++ S++ K K QL+ K E + K++ + A S
Sbjct: 500 ---------KEKQSDSKGKDQERSRS----KEKSKQLESKSNEHDHSKSKEKDRRAQSRS 546
Query: 538 VQIHKQDIVKPEKTV-SHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPP----SI 592
+ DI K + + S + + + + V + + K HR RE
Sbjct: 547 ---RECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGR 603
Query: 593 KTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAE 652
+ + TP G S + +++ + E +E R + +ES H +E
Sbjct: 604 SRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQS----RNKDKYRNQESKSSHRKENSE 659
Query: 653 KPARVSKDVEDVPASKKAKEGTEDVSPTKQKSPIS 687
R+ D +S ++E D + +SP S
Sbjct: 660 SEKRMYSKSRDHNSSNNSREKKAD----RDQSPFS 690
Score = 83.2 bits (204), Expect = 8e-16
Identities = 107/552 (19%), Positives = 221/552 (40%), Gaps = 52/552 (9%)
Query: 111 SDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKD-KTEKQEKPERKIQTKVTHKEKE- 168
SD SS D + D++ ++ RKK+ K+ + K+EK +RK K E E
Sbjct: 202 SDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEA 261
Query: 169 -----KGKEKVREKE---KPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKK 220
+ + VR +E PE + ++ K ++ E K +E+++ S+ + +
Sbjct: 262 ENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQ 321
Query: 221 EVKGGKQEKVKQTAAKVK----EVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMI-- 274
++ V ++ K+K +TPS+ + ++ ++ H +++ R +
Sbjct: 322 -----RRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSS 376
Query: 275 -DIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKE 333
+ ++ GD P R + E K + EKKV ++
Sbjct: 377 GERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKER 436
Query: 334 DIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKK----DEKKEDSKKTKKPAEV 389
DI++ SEK+ + K+ K+ + K ++ K +EK+ S+ + E
Sbjct: 437 DIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHEN 496
Query: 390 EQPKGKKQEKKEKHVEPAKSPKKEHSVPS------DKQVKAKTERAKEEIGAVSIKKAVP 443
+ K K+ + K K E ++S +K + S + K K RA+ I K
Sbjct: 497 VKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKG-- 554
Query: 444 GKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKA 503
K ++T E+ +++S + S D++ + KE + +E E ++ +
Sbjct: 555 --KHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYH-----RYREQEYRRRGRSRSR 607
Query: 504 GKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVK-PEKTVSHGKPEEKVL 562
+ P G+ K + +++++ + E+ Q +D + E SH K +
Sbjct: 608 ERRTPP------GRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESE 661
Query: 563 KQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKES 622
K++ + + + + +K R++ P S K K + + + K K + + S
Sbjct: 662 KRMYSKSRDHNSSNNSREKKADRDQSPFS----KIKQSSQDNELKSSMLKNKEDEKIRSS 717
Query: 623 KEKADMKHLREE 634
EK + K +E
Sbjct: 718 VEKENQKSKGQE 729
Score = 73.9 bits (180), Expect = 5e-13
Identities = 81/390 (20%), Positives = 177/390 (45%), Gaps = 49/390 (12%)
Query: 129 DKGEIDE------PPLRKKEI----HKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKE 178
DK E++E P+R KE H++ +E + K + HK K ++ R E
Sbjct: 384 DKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSE 443
Query: 179 KPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAE----KSEEKTKKEVKGGK-----QEK 229
K +K +K K++K+ K ++++ +KE+ K+K + ++EEK + G+ +EK
Sbjct: 444 KDDK---YKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEK 500
Query: 230 VKQTAAKVKEVQKTPSKPKEKEDKEKAAV---SKHEQKDQYAFCRYMIDIFVHGDLKPGQ 286
KQ+ +K K+ +++ SK K K+ + K+ SK ++KD+ A R D+ G+
Sbjct: 501 EKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSR-----ECDITKGK 555
Query: 287 SPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAID 346
T + SR S + + ++ ++ K E + +++ +++ +
Sbjct: 556 HSY---NSRTRERSRSRDRSRRVRSRTHDRDRSRSK---EYHRYREQEYRRRGRSRSR-- 607
Query: 347 VEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHV-- 404
E++ P S +K + +++++E + +K + E + K+ + EK +
Sbjct: 608 -ERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYS 666
Query: 405 ----EPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRK 460
+ + +E D+ +K +++ ++ S + K++EK +VE+E +K
Sbjct: 667 KSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKS--SMLKNKEDEKIRSSVEKENQK 724
Query: 461 EKSGKTSSILKDKEPIKGKEEKVPASLKEK 490
K + + + + K E P + ++K
Sbjct: 725 SKGQENDHVHEKNK--KFDHESSPGTDEDK 752
Score = 64.7 bits (156), Expect = 3e-10
Identities = 96/438 (21%), Positives = 180/438 (41%), Gaps = 87/438 (19%)
Query: 140 KKEIHKDKTEKQEKPERKIQTKVT-HKEKEKGKEKVREKEKPEK--KATHKEK-----IE 191
K E+++ K E Q P R + K+T H+ + + EKEK K K+ KE+ E
Sbjct: 385 KSELNEIK-ENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSE 443
Query: 192 KKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKE 251
K +K + K K++ K+K+ KS+EK+K + + K + ++ + + SK ++ E
Sbjct: 444 KDDKYKNKV--KKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSR------SKGRDHE 495
Query: 252 D-KEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALE 310
+ KEK S + KDQ + SR S LE
Sbjct: 496 NVKEKEKQSDSKGKDQ-------------------------------ERSRSKEKSKQLE 524
Query: 311 EKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAA 370
K E +K KEK+ ++ + D+ K + S T++ +
Sbjct: 525 SKSNEH--------DHSKSKEKD--RRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRR 574
Query: 371 AKK---DEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTE 427
+ D + SK+ + E E + + +E+ P +S K D++ + +
Sbjct: 575 VRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSK------DRRRRRRDS 628
Query: 428 RAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASL 487
R+ E + S K +E K++ RKE S + ++ + K +S
Sbjct: 629 RSSEREESQSRNKDKYRNQESKSSH------RKENS-------ESEKRMYSKSRDHNSSN 675
Query: 488 KEKEPETKKDE----KMSKAGKEVKPKPPQLQGKKEEKPEPQIKKE-AKPAISEKVQIHK 542
+E + +D+ K+ ++ ++ + K L+ K++EK ++KE K E +H+
Sbjct: 676 NSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHE 735
Query: 543 QDIVKPEKTVSHGKPEEK 560
++ K + S G E+K
Sbjct: 736 KN-KKFDHESSPGTDEDK 752
Score = 52.4 bits (124), Expect = 1e-06
Identities = 56/315 (17%), Positives = 126/315 (40%), Gaps = 24/315 (7%)
Query: 114 ISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDK---TEKQEKPERKIQTKVTHKEKEKG 170
I E+DD K + + KE K K ++ E++++++ ++ E
Sbjct: 438 IRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENV 497
Query: 171 KEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKE--VKGGKQE 228
KEK ++ + K EK ++ E+K+ + K+K ++ + +E + GK
Sbjct: 498 KEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHS 557
Query: 229 KVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSP 288
+T + + ++ D++++ ++ + + + R G + +
Sbjct: 558 YNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRR-------RGRSRSRERR 610
Query: 289 AIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETK---KKEKEDIKK----KSEK 341
P ++ R S + E +E + + +K E+K +KE + +K KS
Sbjct: 611 TPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRD 670
Query: 342 ETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDE--KKEDSKKTKKPAEVEQPKGKKQEK 399
+ + +++ ++ +K ++Q K K ++ +K + E E K K QE
Sbjct: 671 HNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQEN 730
Query: 400 KEKHVEPAKSPKKEH 414
H K+ K +H
Sbjct: 731 DHVH---EKNKKFDH 742
Score = 30.4 bits (67), Expect = 6.1
Identities = 33/143 (23%), Positives = 55/143 (38%), Gaps = 18/143 (12%)
Query: 112 DIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGK 171
D SSE EE ++D + + + RK E E +R H +
Sbjct: 627 DSRSSEREESQSRNKDKYRNQESKSSHRK--------ENSESEKRMYSKSRDHNSSNNSR 678
Query: 172 EKVREKEKPEKKATHKEKIEKKEKP-ETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKV 230
EK K ++ + KI++ + E K+ + K+ + S EK ++ KG + + V
Sbjct: 679 EK-----KADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHV 733
Query: 231 KQTAAKVKEVQKTPSKPKEKEDK 253
+ K S P EDK
Sbjct: 734 HEKNKKFDH----ESSPGTDEDK 752
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 84.3 bits (207), Expect = 4e-16
Identities = 88/517 (17%), Positives = 220/517 (42%), Gaps = 83/517 (16%)
Query: 135 EPPLRKK--EIHKD------KTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATH 186
E P R+ + HKD + +Q++ ER+ + + T +E ++ +E+ REK++ K+ H
Sbjct: 35 ESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRH 94
Query: 187 KEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEV--KGGKQEKVKQT-AAKVKEVQKT 243
+E+ +EK + +E+ + + E++ +K ++ + G++ + +QT + +E Q+
Sbjct: 95 RERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRD 154
Query: 244 PSKPKEKE-DKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRP 302
K +E++ D+E+ ++ ++
Sbjct: 155 AEKERERQTDRERQRQTERNRQ-------------------------------------- 176
Query: 303 TPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKS--------EKETAIDVEKKEPGK 354
+E+E EK + E++ ++KE + + S E+ET + E+K
Sbjct: 177 -------KEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTD 229
Query: 355 ASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEH 414
+Q + + A+++ E + K E E+ + + +++++K E K++
Sbjct: 230 RERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQR 289
Query: 415 SVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKE-------EKTTKTVEQEIRKEKSGKTS 467
D++ + K ER +E + ++E ++ T+ ++ R+ K + +
Sbjct: 290 RTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQT 349
Query: 468 SILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIK 527
+ +++ G+E + A +E+E E ++D ++ +E + + ++++ E Q +
Sbjct: 350 EMDRERNRQTGREGRRQAE-RERERERERDR---QSAREREERERDRDRDRQKERERQTE 405
Query: 528 KEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHRER 587
K+ + Q ++ + E+ G+ EK + + + + T + R+R
Sbjct: 406 KDRDGQRETEKQREREKDRESERGRERGREREKQKGR-------ERDRERQTDRQAGRQR 458
Query: 588 EPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKE 624
+ ++ + P T + ++ + I K S E
Sbjct: 459 KRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPE 495
Score = 82.8 bits (203), Expect = 1e-15
Identities = 74/414 (17%), Positives = 198/414 (47%), Gaps = 31/414 (7%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVRE 176
+D + DD + + K R+ E D+ ++ + + + + + H+E+++ +EK RE
Sbjct: 47 KDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERE 106
Query: 177 KEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAK 236
++ ++ +EK ++K + +E ++ + + ++ ++ + ++E+ +QT
Sbjct: 107 RQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTD-- 164
Query: 237 VKEVQKTPSKPKEKE-DKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLP 295
+E Q+ + ++KE ++EK + E++ Q D H + +
Sbjct: 165 -RERQRQTERNRQKEREREKNRQERRERERQREKENKTED--RHSERGRERERERETETE 221
Query: 296 TEQASRPTPASPALEEKEGEK-KKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGK 354
TE+ + + E E+ K+AE++ SE + + ++ +++ +++ D +KE +
Sbjct: 222 TERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERER 281
Query: 355 ASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEH 414
++ K+ Q ++D + E ++ ++ E E+ + +K+E +E+ E + ++E
Sbjct: 282 QTDRKR-------QRRTERDRETERKRERQRERERERERNRKRE-RERERERERERQRET 333
Query: 415 SVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKE 474
+K+ + K +R E + + G+++ + E+E +E+ +++ +++E
Sbjct: 334 ERDREKERERKRKRQTEMDRERNRQTGREGRRQAER----ERERERERDRQSAREREERE 389
Query: 475 PIKGKEEKVPASLKEKEPETKKD-------EKMSKAGKEVKPKPPQLQGKKEEK 521
+ ++ + KE+E +T+KD EK + K+ + + + +G++ EK
Sbjct: 390 RDRDRDRQ-----KERERQTEKDRDGQRETEKQREREKDRESERGRERGREREK 438
Score = 63.5 bits (153), Expect = 6e-10
Identities = 61/352 (17%), Positives = 161/352 (45%), Gaps = 52/352 (14%)
Query: 116 SEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKP-ERKIQTKVTHKEKEKGKEKV 174
+E E + D + + + + +++E K++ E++E+ +R+ + K + E+G+E+
Sbjct: 155 AEKERERQTDRERQR-QTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERE 213
Query: 175 REKEKPEKKATHKEKIEKKEKPETKTLAKEQKKA---KTAEKSEEKTKKEVKGGKQEKVK 231
RE+E E + K + +++ + KT + +K+A + +E+ E+ K+ + +++ +
Sbjct: 214 RERE-TETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDR 272
Query: 232 QTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIP 291
K +E ++T K + + ++++ K E++
Sbjct: 273 DRRQKERE-RQTDRKRQRRTERDRETERKRERQ--------------------------- 304
Query: 292 PPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKE 351
E+ E+E E+++ ++ T ++KE+E +K +++T +D E+
Sbjct: 305 ----RERERERERNRKRERERERERERERQRETERDREKERE---RKRKRQTEMDRERNR 357
Query: 352 PGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGK-KQEKKEKHVEPAKSP 410
+Q ++ E++ D + ++ E E+ + + +Q+++E+ E +
Sbjct: 358 QTGREGRRQA-------ERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDG 410
Query: 411 KKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEK 462
++E +++ ++ER +E G K+ G++ ++ +T Q R+ K
Sbjct: 411 QRETEKQREREKDRESERGRER-GREREKQ--KGRERDRERQTDRQAGRQRK 459
Score = 62.4 bits (150), Expect = 1e-09
Identities = 71/379 (18%), Positives = 167/379 (44%), Gaps = 45/379 (11%)
Query: 311 EKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAA 370
+KE E+++ +++ ET +K + +K ++ E++ + +Q + Q
Sbjct: 59 QKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQRE 118
Query: 371 AKKDEKKEDSKKTKKPAEV---EQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTE 427
+++ +KE ++T++ E Q G+++ ++++ E KE +D++ + +TE
Sbjct: 119 KERNRQKERERETEREGERGRDRQTDGQRERERQRDAE------KERERQTDRERQRQTE 172
Query: 428 RAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASL 487
R +++ ++E+ + E+E ++EK KT +D+ +G+E +
Sbjct: 173 RNRQK----------EREREKNRQERRERERQREKENKT----EDRHSERGRERE----- 213
Query: 488 KEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVK 547
+E+E ET+ + K + Q K E + E Q ++E A + + K+ +
Sbjct: 214 RERETETETERKRQ------TDRERDRQRKTEREREKQAERER--ASERETERDKERERE 265
Query: 548 PEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEV 607
++ + +++ +Q +T + + T++ R+RE + K + E
Sbjct: 266 RDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERER 325
Query: 608 TESGKKKTE---ISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDV 664
+++TE E+E K K + RE T +E + +AE+ ++ D
Sbjct: 326 ERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRR-----QAERERERERE-RDR 379
Query: 665 PASKKAKEGTEDVSPTKQK 683
++++ +E D +QK
Sbjct: 380 QSAREREERERDRDRDRQK 398
Score = 60.8 bits (146), Expect = 4e-09
Identities = 51/335 (15%), Positives = 146/335 (43%), Gaps = 10/335 (2%)
Query: 310 EEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQA 369
E++ +K+ E++ E ++ + E+E D EK+ + +Q Q
Sbjct: 118 EKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQ------RQT 171
Query: 370 AAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERA 429
+ +++E K ++ E E+ + K+ + +++H E + ++E ++ + K +T+R
Sbjct: 172 ERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRE 231
Query: 430 KEEIGAVSIKKAVPGKKEEKTTKTVE--QEIRKEKSGKTSSILKDKEPIKGKEEK-VPAS 486
++ ++ ++E + + E +E +E+ + KE + + K +
Sbjct: 232 RDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRT 291
Query: 487 LKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIV 546
+++E E K++ + + + + + + + ++E + E Q + E + + +Q +
Sbjct: 292 ERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEM 351
Query: 547 KPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSE 606
E+ G+ + ++ + E+ + ++ R+R+ K ++ + T K
Sbjct: 352 DRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQK-ERERQTEKDRDG 410
Query: 607 VTESGKKKTEISEKESKEKADMKHLREEKVSTRKE 641
E+ K++ ++ES+ + RE++ ++
Sbjct: 411 QRETEKQREREKDRESERGRERGREREKQKGRERD 445
Score = 59.3 bits (142), Expect = 1e-08
Identities = 56/309 (18%), Positives = 151/309 (48%), Gaps = 34/309 (11%)
Query: 116 SEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVR 175
+ED + G E + E + RK++ +++ ++Q K ER+ + K +E+ +E R
Sbjct: 201 TEDRHSERGRERERERETETETERKRQTDRER-DRQRKTERE-REKQAERERASERETER 258
Query: 176 EKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAA 235
+KE+ ++ +++ ++++ E +T K Q++ + ++E K +++ + ++ + +
Sbjct: 259 DKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRE 318
Query: 236 KVKEVQKTPSKPKEKE-DKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPL 294
+ +E ++ + +E E D+EK K +++ + R + + G+
Sbjct: 319 RERERERERERQRETERDREKERERKRKRQTEMDRER---------NRQTGREGR----- 364
Query: 295 PTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKE---DIKKKSEKETAIDVE-KK 350
QA R E+E E+++ +++ E +++E++ D +K+ E++T D + ++
Sbjct: 365 --RQAER---------ERERERER-DRQSAREREERERDRDRDRQKERERQTEKDRDGQR 412
Query: 351 EPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSP 410
E K E ++ + ++ EK++ ++ ++ + ++ G+++++ +V P
Sbjct: 413 ETEKQREREKDRESERGRERGREREKQKGRERDRE-RQTDRQAGRQRKRSTLYVNPPPRT 471
Query: 411 KKEHSVPSD 419
+ V SD
Sbjct: 472 ARSGVVQSD 480
Score = 36.2 bits (82), Expect = 0.11
Identities = 21/91 (23%), Positives = 45/91 (49%), Gaps = 5/91 (5%)
Query: 115 SSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQT-----KVTHKEKEK 169
S+ + E+ + D D D+ + E K + +TEKQ + E+ ++ + +EK+K
Sbjct: 381 SAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQK 440
Query: 170 GKEKVREKEKPEKKATHKEKIEKKEKPETKT 200
G+E+ RE++ + +++ P +T
Sbjct: 441 GRERDRERQTDRQAGRQRKRSTLYVNPPPRT 471
>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
sapiens]
Length = 929
Score = 83.6 bits (205), Expect = 6e-16
Identities = 97/364 (26%), Positives = 155/364 (42%), Gaps = 76/364 (20%)
Query: 77 SASSIAKIGSDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDEP 136
SA++ K GS PL L W D + + + + + I P
Sbjct: 439 SANNFTKSGSTPLPLSGGTSSSDNSWT---MDASIDEVVRKAKLGTPSNMPPNFPYISSP 495
Query: 137 ---PLRKKEIHKDKTEKQEKP-----ERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKE 188
P + +HK EK + P ++K++ ++ K K+K K++ RE+EK + K KE
Sbjct: 496 SVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKE 555
Query: 189 KIEKKEKPETKTLAKEQK-------KAKTAEKSEEKTKKEVKGGKQEKVKQ-TAAKVKEV 240
K + KEK + K +E K K + A+ + K K+ + K+K K KE
Sbjct: 556 KDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEK 615
Query: 241 QKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS 300
K K +EK K+K K + KD+ G ++PA P LP ++ +
Sbjct: 616 HKDKKKDREKGKKDKDKREKEKVKDK-------------GREDKMKAPAPPLVLPPKELA 662
Query: 301 RP--TPAS------------PALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAID 346
P +PA+ P L EK E+K +KV + KKK+K++ KKK EKE
Sbjct: 663 LPLFSPATASRVPAMLPSLLPVLPEKLFEEK---EKVKEKEKKKDKKEKKKKKEKE---- 715
Query: 347 VEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEP 406
KE KK++++E K+ ++ E E+ K K ++ K + V
Sbjct: 716 ---KE--------------------KKEKEREKEKREREKREKEKEKHKHEKIKVEPVAL 752
Query: 407 AKSP 410
A SP
Sbjct: 753 APSP 756
Score = 71.6 bits (174), Expect = 2e-12
Identities = 78/329 (23%), Positives = 137/329 (41%), Gaps = 33/329 (10%)
Query: 287 SPAIPPPLPT-------EQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKS 339
SP++ PP P E+ P+ + K+ K K +KK +++EK+ K KS
Sbjct: 494 SPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKS 553
Query: 340 EKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPK-----G 394
+++ + ++K+ ETK + K+E+ + K K E PK G
Sbjct: 554 KEKDKVKEKEKDKETGRETKYPWKEFL------KEEEADPYKFKIKEFEDVDPKVKLKDG 607
Query: 395 KKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTV 454
+++KEKH + K +K K+ K K E+ K + K P K +
Sbjct: 608 LVRKEKEKHKDKKKDREK------GKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKEL 661
Query: 455 EQEI-RKEKSGKTSSILKDKEPI---KGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPK 510
+ + + ++L P+ K EEK KEK+ + K+ +K + KE K K
Sbjct: 662 ALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEK 721
Query: 511 PPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTI 570
+ + ++ EK E + +K I + V P T+ G ++K++ + V
Sbjct: 722 EREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIV--ISKVVP 779
Query: 571 EKTAKPKPTKKAEHREREPPSIKTDKPKP 599
AKP P +++R + PP P P
Sbjct: 780 APEAKPAP---SQNRPKTPPPAPAPAPGP 805
Score = 61.2 bits (147), Expect = 3e-09
Identities = 106/529 (20%), Positives = 186/529 (35%), Gaps = 49/529 (9%)
Query: 137 PLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKE--KPEKKATHKEKIEKKE 194
PL K K P +K ++ T + +R + EKK+ + K K
Sbjct: 262 PLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSP 321
Query: 195 KPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPK-EKEDK 253
K T Q + E + EK+ + +VK++Q P K E++
Sbjct: 322 KSPKVTTHIPQTPVRP-----ETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQ 376
Query: 254 EKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKE 313
K AV + I+ + + + P P S E E
Sbjct: 377 PKKAVVADKT----------IEASIDAVIARACAEREPDPFEFSSGS----------ESE 416
Query: 314 GEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKK 373
G+ + K+++ K + ++ G +S T+ + +K
Sbjct: 417 GDIFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRK 476
Query: 374 DEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEI 433
+ S + P + H K +++ +PS +VK K K+E+
Sbjct: 477 AKLGTPSNMPPNFPYISSPSVSPPTPEPLH----KVYEEKTKLPSSVEVKKKL---KKEL 529
Query: 434 GAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSIL-KDKEPIKGKEEKVPASLKEKEP 492
K KKE++ + E++ K+KS + + K+K+ G+E K P KE
Sbjct: 530 ------KTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEE 583
Query: 493 ETKKDEKMSKAGKEVKPKPPQLQG--KKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEK 550
E + K ++V PK G +KE++ KK+ + +K + K+ + +
Sbjct: 584 EADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGR 643
Query: 551 TVSHGKPEEKVLKQVKAVTIE----KTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSE 606
P ++ K + + TA P P + +K K K +
Sbjct: 644 EDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKK 703
Query: 607 VTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPA 655
+ KKK E EKE KEK K RE + +++ H K E A
Sbjct: 704 DKKEKKKKKE-KEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVA 751
Score = 50.1 bits (118), Expect = 7e-06
Identities = 61/263 (23%), Positives = 100/263 (38%), Gaps = 76/263 (28%)
Query: 86 SDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIH- 144
+DP K E+ + L ++ E E+ D +D +KG+ D+ K+++
Sbjct: 585 ADPYKFKIKEFEDVDPKV----KLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKD 640
Query: 145 KDKTEKQEKPERK------------------------------IQTKVTHKEKEKGKEKV 174
K + +K + P + + +EKEK KEK
Sbjct: 641 KGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKE 700
Query: 175 REKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTA 234
++K+K EKK +++ EKKEK E+ +EK ++E + ++EK K
Sbjct: 701 KKKDKKEKKKKKEKEKEKKEK----------------EREKEKREREKREKEKEKHKHEK 744
Query: 235 AKVKEVQKTPSKP------KEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQS- 287
KV+ V PS + ++K +SK + + KP S
Sbjct: 745 IKVEPVALAPSPVIPRLTLRVGAGQDKIVISK---------------VVPAPEAKPAPSQ 789
Query: 288 --PAIPPPLPTEQASRPTPASPA 308
P PPP P A P SPA
Sbjct: 790 NRPKTPPPAPA-PAPGPMLVSPA 811
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 83.2 bits (204), Expect = 8e-16
Identities = 144/653 (22%), Positives = 259/653 (39%), Gaps = 82/653 (12%)
Query: 80 SIAKIGSDPLKLVRDAMEETTDWIYGF----FSLLSDIISSEDE-----EDDDGDEDTDK 130
++ I P E T ++GF FS S++IS+ + + G
Sbjct: 908 NLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQA 967
Query: 131 GEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKI 190
+PP + K + P + I K K K + + ++ P K T EK
Sbjct: 968 PAPSQPPTSQGP-PKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKK 1026
Query: 191 EKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVK----------GGKQEKVKQTAAKVKE- 239
K ++K+L E +KA K E+ K E G K T + K
Sbjct: 1027 PPPIK-DSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQ 1085
Query: 240 ------VQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPP 293
TP + +E ++ Q R M P A P P
Sbjct: 1086 VCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPA-------PSGPKASPMP 1138
Query: 294 LPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPG 353
+PTE +S+ T P ++ KK E++V +E +K E +K+ + +EK P
Sbjct: 1139 VPTESSSQKTAVPPQVK----LVKKQEQEVKTEAEKVILEKVKE------TLSMEKIPPM 1188
Query: 354 KASETKQGTVKIAAQAAAKKDEKK---EDSKKTKKPAEV--EQPKGKKQEKKEKHVEPAK 408
++ KQ K+ A+ EKK E+ K + ++ E+ K +EKK +
Sbjct: 1189 VTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKL 1248
Query: 409 SPKKEHSVPSDKQ---VKAKTERAKEEI-GAVSIKKAVPGK----KEEKTTKTVEQEIRK 460
P+ + S P +++ +K++ + A+E++ G V+ K GK K E Q + K
Sbjct: 1249 LPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPK 1308
Query: 461 EKSGKTSSILKDKE-PIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKE 519
E T +I + + P K ++V KEK T+K++ S +PK P QG +
Sbjct: 1309 EDDKTTKTIKEQPQPPCTAKPDQVEPG-KEK---TEKEDDKSDTSSSQQPKSP--QGLSD 1362
Query: 520 EKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGK------PEEKVLKQVKAVTIEKT 573
+ I + ++DI+K K S + P + + ++I +
Sbjct: 1363 TGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEA 1422
Query: 574 AKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLRE 633
+ ++ +P + ++PK K T ++E+ + ISE+E KE + E
Sbjct: 1423 QASTLADEKSEKKTQPHEVSPEQPKDQEK-TQSLSET--LEITISEEEIKESQE-----E 1474
Query: 634 EKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKSPI 686
K + +K+S Q ++ ++ S+ V+D+ ++ + E+ S + SP+
Sbjct: 1475 RKDTFKKDSQQ--DIPSSKDHKEKSEFVDDITTRREPYDSVEE-SSESENSPV 1524
Score = 70.1 bits (170), Expect = 7e-12
Identities = 117/503 (23%), Positives = 192/503 (38%), Gaps = 61/503 (12%)
Query: 194 EKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDK 253
E KT Q K +K E++ K E + EKVK+T + K + K++E K
Sbjct: 1142 ESSSQKTAVPPQ--VKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESK 1199
Query: 254 -EKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEK 312
EK S ++K KP P +P E+ R P LEEK
Sbjct: 1200 LEKDKASALQEK------------------KP--LPEEKKLIPEEEKIRSEEKKPLLEEK 1239
Query: 313 E--GEKKKAEKKVTSETKKKEKEDIKK------KSEKETAIDVEKKEPGKASETK-QGTV 363
+ E KK + + +++K D+ K + + E + + + GK +TK +G
Sbjct: 1240 KPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLP 1299
Query: 364 KIAAQAAAKKDEKKEDSKK-------TKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSV 416
Q+ K+D+K + K T KP +VE K EK EK E KS
Sbjct: 1300 SGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGK----EKTEK--EDDKSDTSSSQQ 1353
Query: 417 PSDKQVKAKTERAKEEIGAV--SIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKE 474
P Q + T + + I + I +P +++ + +E S + S L
Sbjct: 1354 PKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDL---- 1409
Query: 475 PIKGKEEKVPASLKEKEPETKKDEKMSKAGK--EVKPKPPQLQGKKEEKPEPQIKKEAKP 532
K E S+ E + T DEK K + EV P+ P+ Q K + E ++
Sbjct: 1410 ---AKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEE 1466
Query: 533 AISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSI 592
I E Q ++D K K P K K+ + T + +P E S
Sbjct: 1467 EIKES-QEERKDTFK--KDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSP 1523
Query: 593 KTDKPKPTPKGTSEVTESGKKKTEIS--EKESKEKADMKHLREEKVSTRKESLQLHNVTK 650
+ + T G+S E ++ ++ S E++ K ++ +E S ++ + N K
Sbjct: 1524 VPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLK 1583
Query: 651 AEKPARVSKDVEDVPASKKAKEG 673
+ S+ E+ K G
Sbjct: 1584 EISSSTESQKKEETKGKGKITAG 1606
Score = 65.5 bits (158), Expect = 2e-10
Identities = 126/604 (20%), Positives = 224/604 (37%), Gaps = 105/604 (17%)
Query: 136 PPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEK---GKEKVREKEKPEKKATHKEKIEK 192
PP+ + +++++ ++ +Q K E++K +EK+R +EK EK
Sbjct: 1186 PPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLE------EK 1239
Query: 193 KEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTP-------- 244
K PE K L E K + E+ + K +V+ +++ + A K + K P
Sbjct: 1240 KPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLP 1299
Query: 245 -----SKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQA 299
S PKE +DK + + Q C D ++PG+ ++ +
Sbjct: 1300 SGTPQSLPKE-DDKTTKTIKEQPQPP----CTAKPD-----QVEPGKEKTEKEDDKSDTS 1349
Query: 300 SRPTPASPALEEKEGEK----KKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKA 355
S P SP G + ++ S EK+ +K + + + P
Sbjct: 1350 SSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDL 1409
Query: 356 SETKQGTVKI-AAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEH 414
++ + + I AQA+ DEK E KKT +P EV + K QEK + E +
Sbjct: 1410 AKLESTVLSILEAQASTLADEKSE--KKT-QPHEVSPEQPKDQEKTQSLSETLE------ 1460
Query: 415 SVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKE 474
S++++K E K+ S ++ +P K+ KEKS I +E
Sbjct: 1461 ITISEEEIKESQEERKDTFKKDS-QQDIPSSKD-----------HKEKSEFVDDITTRRE 1508
Query: 475 PIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEE-------------- 520
P EE + ++ S + E K + Q G++E+
Sbjct: 1509 PYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADED 1568
Query: 521 ---KPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPK 577
+ + + IS + K++ K + ++ GK + L + + +I++ A +
Sbjct: 1569 ASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGK--HRRLTRKSSTSIDEDAGRR 1626
Query: 578 PTKKAEHRER--EPPSIKTDKPKPTPKGTSEVTESG--------KKKTEISEKESKEKAD 627
+ E E E P +K + K VT G + + I++K S E +
Sbjct: 1627 HSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQ 1686
Query: 628 MK---------HLREEKVSTRKE---------SLQLHNVTKAEKPARVSKDVEDVPASKK 669
K L E ++ E SL + T P VS ED +S
Sbjct: 1687 KKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPS 1746
Query: 670 AKEG 673
K+G
Sbjct: 1747 HKKG 1750
Score = 57.8 bits (138), Expect = 4e-08
Identities = 107/533 (20%), Positives = 187/533 (35%), Gaps = 78/533 (14%)
Query: 179 KPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEV------KGGKQEKVKQ 232
KP + T EK E+P K LA+ KT + K K Q+ Q
Sbjct: 370 KPPAQQTGSEK-PSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQ 428
Query: 233 TAAKVKEVQKTPSKPKE--KEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQS--- 287
+ AK KTP + K ++A K + G KP
Sbjct: 429 SPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQT-------------GPTKPPSQLPG 475
Query: 288 PAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDV 347
PA PPP +P PA P ++ K +++ +++ ++ K ++ +
Sbjct: 476 PAKPPP------QQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKP 529
Query: 348 EKKEPGKASETKQ--GTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVE 405
++PG A + Q K +AQ + K + K + P K + K +
Sbjct: 530 PSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTIC 589
Query: 406 P-AKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSG 464
P + + VP TE + + ++ P E K + ++++ G
Sbjct: 590 PLCNTTELLLHVPEKANFNTCTE-CQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGG 648
Query: 465 KTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEP 524
+ + +P K K +SK+ P+P Q KK+ P+
Sbjct: 649 DLAPVPSSPQP------------KLKTAPVTTTSAVSKSS----PQPQQTSPKKDAAPKQ 692
Query: 525 QIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEH 584
+ K +P K+ ++ HG P K + +A ++ K A PK
Sbjct: 693 DLSKAPEP---------KKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSE 743
Query: 585 REREPPSIKTDKPKPTPKGTSEVTE-----SGKKKTEISEKESKEKADMKHLREEKVSTR 639
+++ P + DKPK PK T+ S K +I + + +A+ K K +
Sbjct: 744 QDKAP--VADDKPK-QPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSA 800
Query: 640 K---------ESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQK 683
K E + + +PA SK + P +G + V P ++K
Sbjct: 801 KPSQSFPPTGEKVSPFDSKAIPRPASDSKIISH-PGPSSESKGQKQVDPVQKK 852
Score = 52.0 bits (123), Expect = 2e-06
Identities = 92/460 (20%), Positives = 167/460 (36%), Gaps = 71/460 (15%)
Query: 140 KKEIHKDKTEKQEKPERKIQTK-VTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPET 198
K+ + D P+ K++T VT ++ P+K A K+ + K +P+
Sbjct: 643 KRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKK 702
Query: 199 KTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAV 258
+Q + ++ K E + + + A K PS P E +DK A
Sbjct: 703 PPPLVKQPTLHGSPSAKAKQPPEA-----DSLSKPAPP-----KEPSVPSE-QDKAPVAD 751
Query: 259 SKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTE--QASRPTPASPALEEKEGEK 316
K +Q + DL S P +P+ Q+ +P L+ +
Sbjct: 752 DKPKQPKM---------VKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKP 802
Query: 317 KKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEK 376
++ + + + I + + I PG +SE+K K K++ K
Sbjct: 803 SQSFPPTGEKVSPFDSKAIPRPASDSKIIS----HPGPSSESKGQ--KQVDPVQKKEEPK 856
Query: 377 KEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAV 436
K +K + KP PKG P P +VP+ +Q E+++ ++
Sbjct: 857 KAQTKMSPKPDAKPMPKGSP-------TPPGPRPTAGQTVPTPQQSPKPQEQSRRF--SL 907
Query: 437 SIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKK 496
++ K + TT ++ + + G +SI + + ++ + P ++
Sbjct: 908 NLGSITDAPKSQPTTP--QETVTGKLFGFGASIFS-------QASNLISTAGQPGPHSQ- 957
Query: 497 DEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGK 556
S G +K P Q + P P+ +A PA P K++
Sbjct: 958 ----SGPGAPMKQAPAPSQPPTSQGP-PKSTGQAPPA--------------PAKSI---- 994
Query: 557 PEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDK 596
P +K K A +E A+ PT K E++PP IK K
Sbjct: 995 PVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSK 1034
Score = 51.2 bits (121), Expect = 3e-06
Identities = 123/600 (20%), Positives = 218/600 (36%), Gaps = 85/600 (14%)
Query: 145 KDKTEKQE---KPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTL 201
KD KQ+ PE K + + G + K+ PE + + K P+ ++
Sbjct: 686 KDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEA-----DSLSKPAPPKEPSV 740
Query: 202 AKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKH 261
EQ KA A+ + K K VK + V ++A K + + E+K +
Sbjct: 741 PSEQDKAPVAD-DKPKQPKMVKP-TTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTD 798
Query: 262 EQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQA-SRPTPASPALEEKEGEK-KKA 319
K +F + P S AIP P + S P P+S + +K+ + +K
Sbjct: 799 SAKPSQSFPP------TGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKK 852
Query: 320 EKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAA--AKKDEKK 377
E+ ++TK K D K + + G+ T Q + K Q+ +
Sbjct: 853 EEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSI 912
Query: 378 EDSKKTKKPAEVEQPKGKK-------------------QEKKEKHVEPAKSPKKEHSVPS 418
D+ K++ E GK Q P +P K+ PS
Sbjct: 913 TDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPG-APMKQAPAPS 971
Query: 419 DKQVKAKTERAKEEIGAVSIKKAVPGKKE------EKTTKTVEQ--EIRKEKSGKTSSIL 470
++ + K ++P KKE EK EQ +++ ++ K +
Sbjct: 972 QPPTSQGPPKSTGQAPPAPAK-SIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPI 1030
Query: 471 KDKEPIKGKEEKVPASLK-EKEPETKKDEKMSKAGKEVKPK-PPQLQGKKEEK------- 521
KD + + + +K K EK P+ + + K + K PP E K
Sbjct: 1031 KDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLC 1090
Query: 522 ---PEPQIKK---------EAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVT 569
P P + + + + AIS ++ DI K S P+ + +
Sbjct: 1091 GFNPTPHLTEIQEWLCLNCQTQRAISGQL----GDIRKMPPAPS--GPKASPMPVPTESS 1144
Query: 570 IEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGK----KKTEISEKESKEK 625
+KTA P K + +E+E +KT+ K + E K T+ ++ESK +
Sbjct: 1145 SQKTAVPPQVKLVKKQEQE---VKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLE 1201
Query: 626 ADMKHLREEK--VSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQK 683
D +EK + K+ + ++E+ + ++ + P KK + +P +QK
Sbjct: 1202 KDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQK 1261
Score = 47.8 bits (112), Expect = 4e-05
Identities = 85/514 (16%), Positives = 193/514 (37%), Gaps = 50/514 (9%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVRE 176
+D+E +T + I E +++ + + T K++ ++ I + HKEK + + +
Sbjct: 1447 KDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDS-QQDIPSSKDHKEKSEFVDDITT 1505
Query: 177 KEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAK 236
+ +P + +E+ + E + + +++ S ++ K+E G E+ +
Sbjct: 1506 RREPY------DSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQ 1559
Query: 237 VKEVQKTPSKPKEKEDK------EKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAI 290
+ E+ ++D+ ++ + S QK + + I H L S +I
Sbjct: 1560 IIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSI 1619
Query: 291 PPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDI--------KKKSEKE 342
E A R +E E + + + ETK +E E++ ++ E
Sbjct: 1620 D-----EDAGRRHSWHDEDDEAFDESPELKYR---ETKSQESEELVVTGGGGLRRFKTIE 1671
Query: 343 TAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEK 402
+ K ++S+ K ++ + E T P + + +G
Sbjct: 1672 LNSTIADKYSAESSQKKTSLY-------FDEEPELEMESLTDSPEDRSRGEGSSSLHASS 1724
Query: 403 HVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEK 462
P SP S+ D ++ G ++ + T+E +E+
Sbjct: 1725 FT-PGTSPTSVSSLDEDSDSSPSHKK-----GESKQQRKARHRPHGPLLPTIEDSSEEEE 1778
Query: 463 SGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKP 522
+ +LK++E + E++ S +K + K + + + + K P L ++ P
Sbjct: 1779 LREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASP 1838
Query: 523 EPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKA 582
++++ A E ++H+ + ++ PE + K + ++K K PT +
Sbjct: 1839 TEELRQAA-----EMEELHRSSCSEYSPSI-ESDPEGFEISPEKIIEVQKVYK-LPTAVS 1891
Query: 583 EHREREPPSI-KTDKPKPTPKGTSEVTESGKKKT 615
+ + SI + + + K E+ E KT
Sbjct: 1892 LYSPTDEQSIMQKEGSQKALKSAEEMYEEMMHKT 1925
Score = 46.6 bits (109), Expect = 8e-05
Identities = 89/401 (22%), Positives = 141/401 (35%), Gaps = 75/401 (18%)
Query: 343 TAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEK 402
+A+ +P + S K K Q +K E K+ K+P P K ++ E
Sbjct: 670 SAVSKSSPQPQQTSPKKDAAPK---QDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEA 726
Query: 403 HVEPAKSPKKEHSVPSD--------------KQVKAKTERAKEEIGAVSIKKAVPGKK-- 446
+P KE SVPS+ K VK T+ + + K +P K
Sbjct: 727 DSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSS--SSATTKPDIPSSKVQ 784
Query: 447 ---EEKTTKTVEQEIRK--------------------EKSGKTSSIL------------K 471
EEKTT ++ + K + S I+ K
Sbjct: 785 SQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQK 844
Query: 472 DKEPIKGKEEKVPASLK-EKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIK-KE 529
+P++ KEE A K +P+ K K S +P Q ++ P+PQ + +
Sbjct: 845 QVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRR 904
Query: 530 AKPAISEKVQIHKQDIVKPEKTVSHGKP---EEKVLKQVKAVTIEKTAKPKPTKKAEHRE 586
+ K P++TV+ GK + Q + I +P P H +
Sbjct: 905 FSLNLGSITDAPKSQPTTPQETVT-GKLFGFGASIFSQASNL-ISTAGQPGP-----HSQ 957
Query: 587 REPPSIKTDKPKPTPKGTSE-VTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQL 645
P + P P+ TS+ +S + K K + K EK+ + E
Sbjct: 958 SGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPT 1017
Query: 646 HNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTK-QKSP 685
T+ EK KD + + A E + V PTK +KSP
Sbjct: 1018 VKRTETEKKPPPIKDSKSLTA-----EPQKAVLPTKLEKSP 1053
Score = 43.5 bits (101), Expect = 7e-04
Identities = 117/526 (22%), Positives = 178/526 (33%), Gaps = 108/526 (20%)
Query: 129 DKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKE 188
D G +P L K +Q+ P R T ++ KE K + + K HK
Sbjct: 101 DPGRPAQPGLSKSRTTDTFRSEQKLPGRSPST-ISLKES---------KSRTDLKEEHKS 150
Query: 189 KIEKKEKPETKTLAKEQKKAKT---------AEKSEEKTKKEVKGGKQEKVKQTAAKVKE 239
+ E L+ +E S+E+T K+ K ++E+ K
Sbjct: 151 SMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPP 210
Query: 240 VQKTPSKPKEK----------EDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPA 289
+Q+ P KP K +D ++S + + I G KP Q P
Sbjct: 211 LQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPE--------KIKSQPPGTGKPIQGPT 262
Query: 290 IPPPLPTEQASRP------TPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKET 343
P T+ A P P + + GE K S+ ++ K +++
Sbjct: 263 QTP--QTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQP- 319
Query: 344 AIDVEKKEPGKASETKQ--GTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKE 401
EK +PG A Q G K AQ + TK PA QP G
Sbjct: 320 --GHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPA---QPLG------- 367
Query: 402 KHVEPAKSPKKE--HSVPSDKQVKAKTERAKEEIGAVSIKKAVPGK---KEEKTTKTVEQ 456
PAK P ++ PS +Q K +G ++ P K ++ T K + Q
Sbjct: 368 ----PAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQ 423
Query: 457 EIRKEKSGKTSSILKD--KEPIKGKEEKVPASL----KEKEPETKKDEKMSKAGKEVKPK 510
+ + K K ++P G K+PA K +T + S+ KP
Sbjct: 424 QPGLQSPAKAPGPTKTPVQQPGPG---KIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKP- 479
Query: 511 PPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTI 570
PPQ G KP PQ AKP P + KP +
Sbjct: 480 PPQQPG--PAKPPPQQPGSAKP---------------PSQQPGSTKPPPQQ--------- 513
Query: 571 EKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTE 616
AKP P + +PPS + KP+ + S S ++ T+
Sbjct: 514 PGPAKPSPQQPG---STKPPSQQPGSAKPSAQQPSPAKPSAQQSTK 556
Score = 43.5 bits (101), Expect = 7e-04
Identities = 82/385 (21%), Positives = 134/385 (34%), Gaps = 76/385 (19%)
Query: 125 DEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVT---HKEKEKGKEKVREKEKPE 181
DED E DE + + TE Q+K E K + K+T H+ + +++
Sbjct: 1566 DEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGR 1625
Query: 182 KKATHKEKIEK-KEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGG------KQEKVKQTA 234
+ + H E E E PE K KS+E + V GG K ++ T
Sbjct: 1626 RHSWHDEDDEAFDESPELK---------YRETKSQESEELVVTGGGGLRRFKTIELNSTI 1676
Query: 235 AKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVH-GDLKPGQSPAIPPP 293
A + + K D+E + R +H PG SP
Sbjct: 1677 ADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSS 1736
Query: 294 LPTEQASRPT------------------PASPALE------------------EKEGEKK 317
L + S P+ P P +E EK+ E +
Sbjct: 1737 LDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIE 1796
Query: 318 KAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKK 377
+ ++K +S+ KK+K++++ + +E K P S + + + AA+ +E
Sbjct: 1797 QQQRKSSSKKSKKDKDELRAQRRRER----PKTPPSNLSPIEDASPTEELRQAAEMEELH 1852
Query: 378 EDSKKTKKPAEVEQPKGKKQEKKEKHVEPAK-----------SPKKEHSV----PSDKQV 422
S P+ P+G + EK +E K SP E S+ S K +
Sbjct: 1853 RSSCSEYSPSIESDPEG-FEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQKAL 1911
Query: 423 KAKTERAKEEIGAVSIKKAVPGKKE 447
K+ E +E + KA P E
Sbjct: 1912 KSAEEMYEEMMHKTHKYKAFPAANE 1936
Score = 42.4 bits (98), Expect = 0.002
Identities = 82/399 (20%), Positives = 146/399 (36%), Gaps = 67/399 (16%)
Query: 280 GDLKPGQSPAIPPP----LPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKED- 334
GDL P P+ P P P S + +SP ++ +K A K+ S+ + +K
Sbjct: 648 GDLAP--VPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPP 705
Query: 335 IKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKG 394
+ K+ + + K+P +A + A E S++ K P ++PK
Sbjct: 706 LVKQPTLHGSPSAKAKQPPEADSLSK---------PAPPKEPSVPSEQDKAPVADDKPKQ 756
Query: 395 KKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIK--KAVPGKKEEKT-- 450
K K + + S + +PS K E+ + S K ++ P E+ +
Sbjct: 757 PKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPF 816
Query: 451 -TKTVEQEIRKEK------SGKTSSILKDKEPIKGKEEKVPASLK-EKEPETKKDEKMSK 502
+K + + K S K +P++ KEE A K +P+ K K S
Sbjct: 817 DSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSP 876
Query: 503 AGKEVKPKPPQLQGKKEEKPEPQIK-KEAKPAISEKVQIHKQDIVKPEKTVSH------- 554
+P Q ++ P+PQ + + + K P++TV+
Sbjct: 877 TPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGA 936
Query: 555 -------------GKPEEKV-------LKQVKAVTIEKTAK--PKPTKKAE--------- 583
G+P +KQ A + T++ PK T +A
Sbjct: 937 SIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPV 996
Query: 584 HREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKES 622
+E + P+ + +PK T + TE+ KK I + +S
Sbjct: 997 KKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKS 1035
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 83.2 bits (204), Expect = 8e-16
Identities = 144/653 (22%), Positives = 259/653 (39%), Gaps = 82/653 (12%)
Query: 80 SIAKIGSDPLKLVRDAMEETTDWIYGF----FSLLSDIISSEDE-----EDDDGDEDTDK 130
++ I P E T ++GF FS S++IS+ + + G
Sbjct: 908 NLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQA 967
Query: 131 GEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKI 190
+PP + K + P + I K K K + + ++ P K T EK
Sbjct: 968 PAPSQPPTSQGP-PKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKK 1026
Query: 191 EKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVK----------GGKQEKVKQTAAKVKE- 239
K ++K+L E +KA K E+ K E G K T + K
Sbjct: 1027 PPPIK-DSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQ 1085
Query: 240 ------VQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPP 293
TP + +E ++ Q R M P A P P
Sbjct: 1086 VCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPA-------PSGPKASPMP 1138
Query: 294 LPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPG 353
+PTE +S+ T P ++ KK E++V +E +K E +K+ + +EK P
Sbjct: 1139 VPTESSSQKTAVPPQVK----LVKKQEQEVKTEAEKVILEKVKE------TLSMEKIPPM 1188
Query: 354 KASETKQGTVKIAAQAAAKKDEKK---EDSKKTKKPAEV--EQPKGKKQEKKEKHVEPAK 408
++ KQ K+ A+ EKK E+ K + ++ E+ K +EKK +
Sbjct: 1189 VTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKL 1248
Query: 409 SPKKEHSVPSDKQ---VKAKTERAKEEI-GAVSIKKAVPGK----KEEKTTKTVEQEIRK 460
P+ + S P +++ +K++ + A+E++ G V+ K GK K E Q + K
Sbjct: 1249 LPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPK 1308
Query: 461 EKSGKTSSILKDKE-PIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKE 519
E T +I + + P K ++V KEK T+K++ S +PK P QG +
Sbjct: 1309 EDDKTTKTIKEQPQPPCTAKPDQVEPG-KEK---TEKEDDKSDTSSSQQPKSP--QGLSD 1362
Query: 520 EKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGK------PEEKVLKQVKAVTIEKT 573
+ I + ++DI+K K S + P + + ++I +
Sbjct: 1363 TGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEA 1422
Query: 574 AKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLRE 633
+ ++ +P + ++PK K T ++E+ + ISE+E KE + E
Sbjct: 1423 QASTLADEKSEKKTQPHEVSPEQPKDQEK-TQSLSET--LEITISEEEIKESQE-----E 1474
Query: 634 EKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKSPI 686
K + +K+S Q ++ ++ S+ V+D+ ++ + E+ S + SP+
Sbjct: 1475 RKDTFKKDSQQ--DIPSSKDHKEKSEFVDDITTRREPYDSVEE-SSESENSPV 1524
Score = 70.1 bits (170), Expect = 7e-12
Identities = 117/503 (23%), Positives = 192/503 (38%), Gaps = 61/503 (12%)
Query: 194 EKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDK 253
E KT Q K +K E++ K E + EKVK+T + K + K++E K
Sbjct: 1142 ESSSQKTAVPPQ--VKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESK 1199
Query: 254 -EKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEK 312
EK S ++K KP P +P E+ R P LEEK
Sbjct: 1200 LEKDKASALQEK------------------KP--LPEEKKLIPEEEKIRSEEKKPLLEEK 1239
Query: 313 E--GEKKKAEKKVTSETKKKEKEDIKK------KSEKETAIDVEKKEPGKASETK-QGTV 363
+ E KK + + +++K D+ K + + E + + + GK +TK +G
Sbjct: 1240 KPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLP 1299
Query: 364 KIAAQAAAKKDEKKEDSKK-------TKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSV 416
Q+ K+D+K + K T KP +VE K EK EK E KS
Sbjct: 1300 SGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGK----EKTEK--EDDKSDTSSSQQ 1353
Query: 417 PSDKQVKAKTERAKEEIGAV--SIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKE 474
P Q + T + + I + I +P +++ + +E S + S L
Sbjct: 1354 PKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDL---- 1409
Query: 475 PIKGKEEKVPASLKEKEPETKKDEKMSKAGK--EVKPKPPQLQGKKEEKPEPQIKKEAKP 532
K E S+ E + T DEK K + EV P+ P+ Q K + E ++
Sbjct: 1410 ---AKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEE 1466
Query: 533 AISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSI 592
I E Q ++D K K P K K+ + T + +P E S
Sbjct: 1467 EIKES-QEERKDTFK--KDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSP 1523
Query: 593 KTDKPKPTPKGTSEVTESGKKKTEIS--EKESKEKADMKHLREEKVSTRKESLQLHNVTK 650
+ + T G+S E ++ ++ S E++ K ++ +E S ++ + N K
Sbjct: 1524 VPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLK 1583
Query: 651 AEKPARVSKDVEDVPASKKAKEG 673
+ S+ E+ K G
Sbjct: 1584 EISSSTESQKKEETKGKGKITAG 1606
Score = 65.5 bits (158), Expect = 2e-10
Identities = 126/604 (20%), Positives = 224/604 (37%), Gaps = 105/604 (17%)
Query: 136 PPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEK---GKEKVREKEKPEKKATHKEKIEK 192
PP+ + +++++ ++ +Q K E++K +EK+R +EK EK
Sbjct: 1186 PPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLE------EK 1239
Query: 193 KEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTP-------- 244
K PE K L E K + E+ + K +V+ +++ + A K + K P
Sbjct: 1240 KPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLP 1299
Query: 245 -----SKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQA 299
S PKE +DK + + Q C D ++PG+ ++ +
Sbjct: 1300 SGTPQSLPKE-DDKTTKTIKEQPQPP----CTAKPD-----QVEPGKEKTEKEDDKSDTS 1349
Query: 300 SRPTPASPALEEKEGEK----KKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKA 355
S P SP G + ++ S EK+ +K + + + P
Sbjct: 1350 SSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDL 1409
Query: 356 SETKQGTVKI-AAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEH 414
++ + + I AQA+ DEK E KKT +P EV + K QEK + E +
Sbjct: 1410 AKLESTVLSILEAQASTLADEKSE--KKT-QPHEVSPEQPKDQEKTQSLSETLE------ 1460
Query: 415 SVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKE 474
S++++K E K+ S ++ +P K+ KEKS I +E
Sbjct: 1461 ITISEEEIKESQEERKDTFKKDS-QQDIPSSKD-----------HKEKSEFVDDITTRRE 1508
Query: 475 PIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEE-------------- 520
P EE + ++ S + E K + Q G++E+
Sbjct: 1509 PYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADED 1568
Query: 521 ---KPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPK 577
+ + + IS + K++ K + ++ GK + L + + +I++ A +
Sbjct: 1569 ASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGK--HRRLTRKSSTSIDEDAGRR 1626
Query: 578 PTKKAEHRER--EPPSIKTDKPKPTPKGTSEVTESG--------KKKTEISEKESKEKAD 627
+ E E E P +K + K VT G + + I++K S E +
Sbjct: 1627 HSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQ 1686
Query: 628 MK---------HLREEKVSTRKE---------SLQLHNVTKAEKPARVSKDVEDVPASKK 669
K L E ++ E SL + T P VS ED +S
Sbjct: 1687 KKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPS 1746
Query: 670 AKEG 673
K+G
Sbjct: 1747 HKKG 1750
Score = 57.8 bits (138), Expect = 4e-08
Identities = 107/533 (20%), Positives = 187/533 (35%), Gaps = 78/533 (14%)
Query: 179 KPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEV------KGGKQEKVKQ 232
KP + T EK E+P K LA+ KT + K K Q+ Q
Sbjct: 370 KPPAQQTGSEK-PSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQ 428
Query: 233 TAAKVKEVQKTPSKPKE--KEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQS--- 287
+ AK KTP + K ++A K + G KP
Sbjct: 429 SPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQT-------------GPTKPPSQLPG 475
Query: 288 PAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDV 347
PA PPP +P PA P ++ K +++ +++ ++ K ++ +
Sbjct: 476 PAKPPP------QQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKP 529
Query: 348 EKKEPGKASETKQ--GTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVE 405
++PG A + Q K +AQ + K + K + P K + K +
Sbjct: 530 PSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTIC 589
Query: 406 P-AKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSG 464
P + + VP TE + + ++ P E K + ++++ G
Sbjct: 590 PLCNTTELLLHVPEKANFNTCTE-CQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGG 648
Query: 465 KTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEP 524
+ + +P K K +SK+ P+P Q KK+ P+
Sbjct: 649 DLAPVPSSPQP------------KLKTAPVTTTSAVSKSS----PQPQQTSPKKDAAPKQ 692
Query: 525 QIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEH 584
+ K +P K+ ++ HG P K + +A ++ K A PK
Sbjct: 693 DLSKAPEP---------KKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSE 743
Query: 585 REREPPSIKTDKPKPTPKGTSEVTE-----SGKKKTEISEKESKEKADMKHLREEKVSTR 639
+++ P + DKPK PK T+ S K +I + + +A+ K K +
Sbjct: 744 QDKAP--VADDKPK-QPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSA 800
Query: 640 K---------ESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQK 683
K E + + +PA SK + P +G + V P ++K
Sbjct: 801 KPSQSFPPTGEKVSPFDSKAIPRPASDSKIISH-PGPSSESKGQKQVDPVQKK 852
Score = 52.0 bits (123), Expect = 2e-06
Identities = 92/460 (20%), Positives = 167/460 (36%), Gaps = 71/460 (15%)
Query: 140 KKEIHKDKTEKQEKPERKIQTK-VTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPET 198
K+ + D P+ K++T VT ++ P+K A K+ + K +P+
Sbjct: 643 KRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKK 702
Query: 199 KTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAV 258
+Q + ++ K E + + + A K PS P E +DK A
Sbjct: 703 PPPLVKQPTLHGSPSAKAKQPPEA-----DSLSKPAPP-----KEPSVPSE-QDKAPVAD 751
Query: 259 SKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTE--QASRPTPASPALEEKEGEK 316
K +Q + DL S P +P+ Q+ +P L+ +
Sbjct: 752 DKPKQPKM---------VKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKP 802
Query: 317 KKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEK 376
++ + + + I + + I PG +SE+K K K++ K
Sbjct: 803 SQSFPPTGEKVSPFDSKAIPRPASDSKIIS----HPGPSSESKGQ--KQVDPVQKKEEPK 856
Query: 377 KEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAV 436
K +K + KP PKG P P +VP+ +Q E+++ ++
Sbjct: 857 KAQTKMSPKPDAKPMPKGSP-------TPPGPRPTAGQTVPTPQQSPKPQEQSRRF--SL 907
Query: 437 SIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKK 496
++ K + TT ++ + + G +SI + + ++ + P ++
Sbjct: 908 NLGSITDAPKSQPTTP--QETVTGKLFGFGASIFS-------QASNLISTAGQPGPHSQ- 957
Query: 497 DEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGK 556
S G +K P Q + P P+ +A PA P K++
Sbjct: 958 ----SGPGAPMKQAPAPSQPPTSQGP-PKSTGQAPPA--------------PAKSI---- 994
Query: 557 PEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDK 596
P +K K A +E A+ PT K E++PP IK K
Sbjct: 995 PVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSK 1034
Score = 51.2 bits (121), Expect = 3e-06
Identities = 123/600 (20%), Positives = 218/600 (36%), Gaps = 85/600 (14%)
Query: 145 KDKTEKQE---KPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTL 201
KD KQ+ PE K + + G + K+ PE + + K P+ ++
Sbjct: 686 KDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEA-----DSLSKPAPPKEPSV 740
Query: 202 AKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKH 261
EQ KA A+ + K K VK + V ++A K + + E+K +
Sbjct: 741 PSEQDKAPVAD-DKPKQPKMVKP-TTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTD 798
Query: 262 EQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQA-SRPTPASPALEEKEGEK-KKA 319
K +F + P S AIP P + S P P+S + +K+ + +K
Sbjct: 799 SAKPSQSFPP------TGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKK 852
Query: 320 EKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAA--AKKDEKK 377
E+ ++TK K D K + + G+ T Q + K Q+ +
Sbjct: 853 EEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSI 912
Query: 378 EDSKKTKKPAEVEQPKGKK-------------------QEKKEKHVEPAKSPKKEHSVPS 418
D+ K++ E GK Q P +P K+ PS
Sbjct: 913 TDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPG-APMKQAPAPS 971
Query: 419 DKQVKAKTERAKEEIGAVSIKKAVPGKKE------EKTTKTVEQ--EIRKEKSGKTSSIL 470
++ + K ++P KKE EK EQ +++ ++ K +
Sbjct: 972 QPPTSQGPPKSTGQAPPAPAK-SIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPI 1030
Query: 471 KDKEPIKGKEEKVPASLK-EKEPETKKDEKMSKAGKEVKPK-PPQLQGKKEEK------- 521
KD + + + +K K EK P+ + + K + K PP E K
Sbjct: 1031 KDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLC 1090
Query: 522 ---PEPQIKK---------EAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVT 569
P P + + + + AIS ++ DI K S P+ + +
Sbjct: 1091 GFNPTPHLTEIQEWLCLNCQTQRAISGQL----GDIRKMPPAPS--GPKASPMPVPTESS 1144
Query: 570 IEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGK----KKTEISEKESKEK 625
+KTA P K + +E+E +KT+ K + E K T+ ++ESK +
Sbjct: 1145 SQKTAVPPQVKLVKKQEQE---VKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLE 1201
Query: 626 ADMKHLREEK--VSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQK 683
D +EK + K+ + ++E+ + ++ + P KK + +P +QK
Sbjct: 1202 KDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQK 1261
Score = 47.8 bits (112), Expect = 4e-05
Identities = 85/514 (16%), Positives = 193/514 (37%), Gaps = 50/514 (9%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVRE 176
+D+E +T + I E +++ + + T K++ ++ I + HKEK + + +
Sbjct: 1447 KDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDS-QQDIPSSKDHKEKSEFVDDITT 1505
Query: 177 KEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAK 236
+ +P + +E+ + E + + +++ S ++ K+E G E+ +
Sbjct: 1506 RREPY------DSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQ 1559
Query: 237 VKEVQKTPSKPKEKEDK------EKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAI 290
+ E+ ++D+ ++ + S QK + + I H L S +I
Sbjct: 1560 IIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSI 1619
Query: 291 PPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDI--------KKKSEKE 342
E A R +E E + + + ETK +E E++ ++ E
Sbjct: 1620 D-----EDAGRRHSWHDEDDEAFDESPELKYR---ETKSQESEELVVTGGGGLRRFKTIE 1671
Query: 343 TAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEK 402
+ K ++S+ K ++ + E T P + + +G
Sbjct: 1672 LNSTIADKYSAESSQKKTSLY-------FDEEPELEMESLTDSPEDRSRGEGSSSLHASS 1724
Query: 403 HVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEK 462
P SP S+ D ++ G ++ + T+E +E+
Sbjct: 1725 FT-PGTSPTSVSSLDEDSDSSPSHKK-----GESKQQRKARHRPHGPLLPTIEDSSEEEE 1778
Query: 463 SGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKP 522
+ +LK++E + E++ S +K + K + + + + K P L ++ P
Sbjct: 1779 LREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASP 1838
Query: 523 EPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKA 582
++++ A E ++H+ + ++ PE + K + ++K K PT +
Sbjct: 1839 TEELRQAA-----EMEELHRSSCSEYSPSI-ESDPEGFEISPEKIIEVQKVYK-LPTAVS 1891
Query: 583 EHREREPPSI-KTDKPKPTPKGTSEVTESGKKKT 615
+ + SI + + + K E+ E KT
Sbjct: 1892 LYSPTDEQSIMQKEGSQKALKSAEEMYEEMMHKT 1925
Score = 46.6 bits (109), Expect = 8e-05
Identities = 89/401 (22%), Positives = 141/401 (35%), Gaps = 75/401 (18%)
Query: 343 TAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEK 402
+A+ +P + S K K Q +K E K+ K+P P K ++ E
Sbjct: 670 SAVSKSSPQPQQTSPKKDAAPK---QDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEA 726
Query: 403 HVEPAKSPKKEHSVPSD--------------KQVKAKTERAKEEIGAVSIKKAVPGKK-- 446
+P KE SVPS+ K VK T+ + + K +P K
Sbjct: 727 DSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSS--SSATTKPDIPSSKVQ 784
Query: 447 ---EEKTTKTVEQEIRK--------------------EKSGKTSSIL------------K 471
EEKTT ++ + K + S I+ K
Sbjct: 785 SQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQK 844
Query: 472 DKEPIKGKEEKVPASLK-EKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIK-KE 529
+P++ KEE A K +P+ K K S +P Q ++ P+PQ + +
Sbjct: 845 QVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRR 904
Query: 530 AKPAISEKVQIHKQDIVKPEKTVSHGKP---EEKVLKQVKAVTIEKTAKPKPTKKAEHRE 586
+ K P++TV+ GK + Q + I +P P H +
Sbjct: 905 FSLNLGSITDAPKSQPTTPQETVT-GKLFGFGASIFSQASNL-ISTAGQPGP-----HSQ 957
Query: 587 REPPSIKTDKPKPTPKGTSE-VTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQL 645
P + P P+ TS+ +S + K K + K EK+ + E
Sbjct: 958 SGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPT 1017
Query: 646 HNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTK-QKSP 685
T+ EK KD + + A E + V PTK +KSP
Sbjct: 1018 VKRTETEKKPPPIKDSKSLTA-----EPQKAVLPTKLEKSP 1053
Score = 43.5 bits (101), Expect = 7e-04
Identities = 117/526 (22%), Positives = 178/526 (33%), Gaps = 108/526 (20%)
Query: 129 DKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKE 188
D G +P L K +Q+ P R T ++ KE K + + K HK
Sbjct: 101 DPGRPAQPGLSKSRTTDTFRSEQKLPGRSPST-ISLKES---------KSRTDLKEEHKS 150
Query: 189 KIEKKEKPETKTLAKEQKKAKT---------AEKSEEKTKKEVKGGKQEKVKQTAAKVKE 239
+ E L+ +E S+E+T K+ K ++E+ K
Sbjct: 151 SMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPP 210
Query: 240 VQKTPSKPKEK----------EDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPA 289
+Q+ P KP K +D ++S + + I G KP Q P
Sbjct: 211 LQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPE--------KIKSQPPGTGKPIQGPT 262
Query: 290 IPPPLPTEQASRP------TPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKET 343
P T+ A P P + + GE K S+ ++ K +++
Sbjct: 263 QTP--QTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQP- 319
Query: 344 AIDVEKKEPGKASETKQ--GTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKE 401
EK +PG A Q G K AQ + TK PA QP G
Sbjct: 320 --GHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPA---QPLG------- 367
Query: 402 KHVEPAKSPKKE--HSVPSDKQVKAKTERAKEEIGAVSIKKAVPGK---KEEKTTKTVEQ 456
PAK P ++ PS +Q K +G ++ P K ++ T K + Q
Sbjct: 368 ----PAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQ 423
Query: 457 EIRKEKSGKTSSILKD--KEPIKGKEEKVPASL----KEKEPETKKDEKMSKAGKEVKPK 510
+ + K K ++P G K+PA K +T + S+ KP
Sbjct: 424 QPGLQSPAKAPGPTKTPVQQPGPG---KIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKP- 479
Query: 511 PPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTI 570
PPQ G KP PQ AKP P + KP +
Sbjct: 480 PPQQPG--PAKPPPQQPGSAKP---------------PSQQPGSTKPPPQQ--------- 513
Query: 571 EKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTE 616
AKP P + +PPS + KP+ + S S ++ T+
Sbjct: 514 PGPAKPSPQQPG---STKPPSQQPGSAKPSAQQPSPAKPSAQQSTK 556
Score = 43.5 bits (101), Expect = 7e-04
Identities = 82/385 (21%), Positives = 134/385 (34%), Gaps = 76/385 (19%)
Query: 125 DEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVT---HKEKEKGKEKVREKEKPE 181
DED E DE + + TE Q+K E K + K+T H+ + +++
Sbjct: 1566 DEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGR 1625
Query: 182 KKATHKEKIEK-KEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGG------KQEKVKQTA 234
+ + H E E E PE K KS+E + V GG K ++ T
Sbjct: 1626 RHSWHDEDDEAFDESPELK---------YRETKSQESEELVVTGGGGLRRFKTIELNSTI 1676
Query: 235 AKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVH-GDLKPGQSPAIPPP 293
A + + K D+E + R +H PG SP
Sbjct: 1677 ADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSS 1736
Query: 294 LPTEQASRPT------------------PASPALE------------------EKEGEKK 317
L + S P+ P P +E EK+ E +
Sbjct: 1737 LDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIE 1796
Query: 318 KAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKK 377
+ ++K +S+ KK+K++++ + +E K P S + + + AA+ +E
Sbjct: 1797 QQQRKSSSKKSKKDKDELRAQRRRER----PKTPPSNLSPIEDASPTEELRQAAEMEELH 1852
Query: 378 EDSKKTKKPAEVEQPKGKKQEKKEKHVEPAK-----------SPKKEHSV----PSDKQV 422
S P+ P+G + EK +E K SP E S+ S K +
Sbjct: 1853 RSSCSEYSPSIESDPEG-FEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQKAL 1911
Query: 423 KAKTERAKEEIGAVSIKKAVPGKKE 447
K+ E +E + KA P E
Sbjct: 1912 KSAEEMYEEMMHKTHKYKAFPAANE 1936
Score = 42.4 bits (98), Expect = 0.002
Identities = 82/399 (20%), Positives = 146/399 (36%), Gaps = 67/399 (16%)
Query: 280 GDLKPGQSPAIPPP----LPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKED- 334
GDL P P+ P P P S + +SP ++ +K A K+ S+ + +K
Sbjct: 648 GDLAP--VPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPP 705
Query: 335 IKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKG 394
+ K+ + + K+P +A + A E S++ K P ++PK
Sbjct: 706 LVKQPTLHGSPSAKAKQPPEADSLSK---------PAPPKEPSVPSEQDKAPVADDKPKQ 756
Query: 395 KKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIK--KAVPGKKEEKT-- 450
K K + + S + +PS K E+ + S K ++ P E+ +
Sbjct: 757 PKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPF 816
Query: 451 -TKTVEQEIRKEK------SGKTSSILKDKEPIKGKEEKVPASLK-EKEPETKKDEKMSK 502
+K + + K S K +P++ KEE A K +P+ K K S
Sbjct: 817 DSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSP 876
Query: 503 AGKEVKPKPPQLQGKKEEKPEPQIK-KEAKPAISEKVQIHKQDIVKPEKTVSH------- 554
+P Q ++ P+PQ + + + K P++TV+
Sbjct: 877 TPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGA 936
Query: 555 -------------GKPEEKV-------LKQVKAVTIEKTAK--PKPTKKAE--------- 583
G+P +KQ A + T++ PK T +A
Sbjct: 937 SIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPV 996
Query: 584 HREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKES 622
+E + P+ + +PK T + TE+ KK I + +S
Sbjct: 997 KKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKS 1035
>gi|4557509 cylicin 2 [Homo sapiens]
Length = 348
Score = 82.8 bits (203), Expect = 1e-15
Identities = 79/269 (29%), Positives = 117/269 (43%), Gaps = 43/269 (15%)
Query: 120 EDDDGDEDTDKGEIDEPPLRKKEIHKDKT---EKQEKPERKIQTKVTHKEKEKGKEKVRE 176
ED +DT E E KK+ K K K+EK + K +K K+ EKGK+ E
Sbjct: 119 EDKTTQKDTTDSE-SELKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGKKDAEKGKDSATE 177
Query: 177 KEKPEKKATHKEKIEKKEKPETKTLAKEQKKAK-TAEKSEEKTKKEVKGGKQEKVKQTAA 235
E + A K +KK+ + K A E + K EK +K KK+ K GK ++ A
Sbjct: 178 SEDEKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIELQAV 237
Query: 236 KVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLP 295
K E K+ ED +K A E KD + ++K G+
Sbjct: 238 KADE--------KKDEDGKKDANKGDESKDAKKDAK---------EIKKGKK-------- 272
Query: 296 TEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKA 355
+ P+S + K+ KK+++K T + KK K+D +K+S + K+ K
Sbjct: 273 ----DKKKPSSTDSDSKDDVKKESKKDATKDAKKVAKKDTEKES-------ADSKKDAKK 321
Query: 356 SETKQGTVKIAAQAAAKKDEKKEDSKKTK 384
+ K K A+ AKKDEKK+ KK K
Sbjct: 322 NAKKD--AKKDAKKNAKKDEKKDAKKKGK 348
Score = 71.6 bits (174), Expect = 2e-12
Identities = 77/275 (28%), Positives = 117/275 (42%), Gaps = 49/275 (17%)
Query: 78 ASSIAKIGSDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDEPP 137
A+ I K G D + ++TTD S+ + ++D +D +KG+ ++
Sbjct: 111 AAEIGKKGED-----KTTQKDTTD---------SESELKQGKKDSKKGKDIEKGKEEKLD 156
Query: 138 LRK------KEIHKDK---TEKQ-EKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHK 187
+K K+ K K TE + EK K K K+ KGK+ E E EK T K
Sbjct: 157 AKKDSKKGKKDAEKGKDSATESEDEKGGAKKDNKKDKKDSNKGKDSATESE-GEKGGTEK 215
Query: 188 E-KIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEV-KGGKQEKVKQTAAKVKEVQKTPS 245
+ K KK+ + K A E + K EK +E KK+ KG + + K+ A ++K+ +K
Sbjct: 216 DSKKGKKDSKKGKDSAIELQAVKADEKKDEDGKKDANKGDESKDAKKDAKEIKKGKKDKK 275
Query: 246 KPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPA 305
KP + K V K +KD K + A TE+ S A
Sbjct: 276 KPSSTDSDSKDDVKKESKKDA---------------TKDAKKVA---KKDTEKES----A 313
Query: 306 SPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSE 340
+ K+ KK A+K KK EK+D KKK +
Sbjct: 314 DSKKDAKKNAKKDAKKDAKKNAKKDEKKDAKKKGK 348
Score = 70.5 bits (171), Expect = 5e-12
Identities = 72/278 (25%), Positives = 119/278 (42%), Gaps = 36/278 (12%)
Query: 153 KPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAE 212
KP R ++ V K E GK K E K T K+ + + E K K+ KK K E
Sbjct: 100 KPTRTVE--VDSKAAEIGK-------KGEDKTTQKDTTDSES--ELKQGKKDSKKGKDIE 148
Query: 213 KSEEK---TKKEVKGGKQ--EKVKQTAAKVKEVQKTPSK--PKEKEDKEKAAVSKHEQKD 265
K +E+ KK+ K GK+ EK K +A + ++ + K K+K+D K S E +
Sbjct: 149 KGKEEKLDAKKDSKKGKKDAEKGKDSATESEDEKGGAKKDNKKDKKDSNKGKDSATESEG 208
Query: 266 QYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTS 325
+ D K G+ + + + ++ L+ + ++KK E
Sbjct: 209 EKG--------GTEKDSKKGK----------KDSKKGKDSAIELQAVKADEKKDEDGKKD 250
Query: 326 ETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKK 385
K E +D KK +++ +KK+P + VK ++ A KD KK K T+K
Sbjct: 251 ANKGDESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKESKKDATKDAKKVAKKDTEK 310
Query: 386 PAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVK 423
+ + KK KK+ + K+ KK+ + K+ K
Sbjct: 311 ESADSKKDAKKNAKKDAKKDAKKNAKKDEKKDAKKKGK 348
Score = 63.9 bits (154), Expect = 5e-10
Identities = 64/232 (27%), Positives = 108/232 (46%), Gaps = 15/232 (6%)
Query: 312 KEGEKKKAEKKVT-SETKKKE-KEDIKKKSE----KETAIDVEKKEPGKASETKQGTVKI 365
K+GE K +K T SE++ K+ K+D KK + KE +D KK+ K + +
Sbjct: 116 KKGEDKTTQKDTTDSESELKQGKKDSKKGKDIEKGKEEKLDA-KKDSKKGKKDAEKGKDS 174
Query: 366 AAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVE-PAKSPKKEHSVPSDKQVK- 423
A ++ +K K+D+KK KK + + + E ++ E +K KK+ D ++
Sbjct: 175 ATESEDEKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIEL 234
Query: 424 --AKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEE 481
K + K+E G K K +K K +++ +K+K +S+ K+ +K KE
Sbjct: 235 QAVKADEKKDEDGKKDANKGDESKDAKKDAKEIKKG-KKDKKKPSSTDSDSKDDVK-KES 292
Query: 482 KVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEK--PEPQIKKEAK 531
K A+ K+ K EK S K+ K + KK+ K + KK+AK
Sbjct: 293 KKDATKDAKKVAKKDTEKESADSKKDAKKNAKKDAKKDAKKNAKKDEKKDAK 344
Score = 62.8 bits (151), Expect = 1e-09
Identities = 79/295 (26%), Positives = 115/295 (38%), Gaps = 41/295 (13%)
Query: 339 SEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQE 398
SE+ + +++P K + T + K AA+ K ++K T +E++Q GKK
Sbjct: 85 SERPSVYLAARRQPLKPTRTVEVDSK-AAEIGKKGEDKTTQKDTTDSESELKQ--GKKDS 141
Query: 399 KKEKHVEPAKSPKKEHSVPSDKQVK-------AKTERAKEEIGAVSIKKAVPGKKEEKTT 451
KK K +E K K + S K K + TE E+ GA K KK+
Sbjct: 142 KKGKDIEKGKEEKLDAKKDSKKGKKDAEKGKDSATESEDEKGGAKKDNKK--DKKDSNKG 199
Query: 452 KTVEQEIRKEKSGKTSSILKDKEPIK-GKEEKVPASLKEKEPETKKDEKMSKAGKEVKPK 510
K E EK G K K+ K GK+ + K DEK + GK+ K
Sbjct: 200 KDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIELQA------VKADEKKDEDGKKDANK 253
Query: 511 PPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTI 570
+ K +K +IKK K+D KP T S K + K + A
Sbjct: 254 GD--ESKDAKKDAKEIKK------------GKKDKKKPSSTDSDSKDDVKKESKKDATKD 299
Query: 571 EKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEK 625
K K T E+E K D K K + + KK E +K++K+K
Sbjct: 300 AKKVAKKDT------EKESADSKKDAKKNAKKDAKKDAKKNAKKDE--KKDAKKK 346
Score = 59.7 bits (143), Expect = 9e-09
Identities = 70/246 (28%), Positives = 111/246 (45%), Gaps = 34/246 (13%)
Query: 436 VSIKKAVPGKK-EEKTTKTVEQEIRKE-KSGKTSSILKDKEPIKGKEEKVPASLKEKEPE 493
V K A GKK E+KTT+ + E K GK S K K+ KGKEEK+ A + +
Sbjct: 107 VDSKAAEIGKKGEDKTTQKDTTDSESELKQGKKDS-KKGKDIEKGKEEKLDA-----KKD 160
Query: 494 TKKDEKMSKAGKEVKPKPPQLQG--KKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEK- 550
+KK +K ++ GK+ + +G KK+ K + + + K + +E + EK
Sbjct: 161 SKKGKKDAEKGKDSATESEDEKGGAKKDNKKDKKDSNKGKDSATES---------EGEKG 211
Query: 551 -TVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTE 609
T K +K K+ K IE A KK E +++ + K D+ K K E+ +
Sbjct: 212 GTEKDSKKGKKDSKKGKDSAIELQAVKADEKKDEDGKKD--ANKGDESKDAKKDAKEIKK 269
Query: 610 SGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKK 669
K K + S +S K D+K +E K K+ A+K A+ + E + K
Sbjct: 270 GKKDKKKPSSTDSDSKDDVK--KESKKDATKD---------AKKVAKKDTEKESADSKKD 318
Query: 670 AKEGTE 675
AK+ +
Sbjct: 319 AKKNAK 324
Score = 52.4 bits (124), Expect = 1e-06
Identities = 60/212 (28%), Positives = 97/212 (45%), Gaps = 23/212 (10%)
Query: 310 EEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQA 369
+ K+G+K + K ++ + EK KK ++K D + GK S T+ K +
Sbjct: 160 DSKKGKKDAEKGKDSATESEDEKGGAKKDNKK----DKKDSNKGKDSATESEGEKGGTEK 215
Query: 370 AAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERA 429
+KK K+DSKK K A +E K EKK++ K+ + D+ AK + A
Sbjct: 216 DSKKG--KKDSKKGKDSA-IELQAVKADEKKDE-------DGKKDANKGDESKDAKKD-A 264
Query: 430 KEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKE 489
KE IKK KK+ +T + ++ K++S K ++ K K E++ S K+
Sbjct: 265 KE------IKKGKKDKKKPSSTDSDSKDDVKKESKKDATKDAKKVAKKDTEKESADSKKD 318
Query: 490 KEPETKKDEKMSKAGKEVKPKPPQLQGKKEEK 521
+ KKD K K K+ K + KK+ K
Sbjct: 319 AKKNAKKDAK--KDAKKNAKKDEKKDAKKKGK 348
Score = 35.0 bits (79), Expect = 0.25
Identities = 28/108 (25%), Positives = 52/108 (48%), Gaps = 4/108 (3%)
Query: 577 KPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKV 636
KPT+ E + K + K T K T++ +ES K+ +K+SK+ D++ +EEK+
Sbjct: 100 KPTRTVEVDSKAAEIGKKGEDKTTQKDTTD-SESELKQ---GKKDSKKGKDIEKGKEEKL 155
Query: 637 STRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKS 684
+K+S + + K + + E A K K+ +D + K +
Sbjct: 156 DAKKDSKKGKKDAEKGKDSATESEDEKGGAKKDNKKDKKDSNKGKDSA 203
Score = 34.3 bits (77), Expect = 0.42
Identities = 45/207 (21%), Positives = 81/207 (39%), Gaps = 24/207 (11%)
Query: 484 PASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIH-- 541
P + + +P +D +S +E QL+G ++ +P + ISE+ ++
Sbjct: 43 PGTKRRSKPSQIRDNTVSIIDEE------QLRG---DRRQPLWMYRSLMRISERPSVYLA 93
Query: 542 -KQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKK-AEHREREPPSIKTD--KP 597
++ +KP +TV KA I K + K T+K E E K D K
Sbjct: 94 ARRQPLKPTRTVEVDS---------KAAEIGKKGEDKTTQKDTTDSESELKQGKKDSKKG 144
Query: 598 KPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARV 657
K KG E ++ K + + K K +EK +K++ + + K +
Sbjct: 145 KDIEKGKEEKLDAKKDSKKGKKDAEKGKDSATESEDEKGGAKKDNKKDKKDSNKGKDSAT 204
Query: 658 SKDVEDVPASKKAKEGTEDVSPTKQKS 684
+ E K +K+G +D K +
Sbjct: 205 ESEGEKGGTEKDSKKGKKDSKKGKDSA 231
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 82.4 bits (202), Expect = 1e-15
Identities = 137/613 (22%), Positives = 272/613 (44%), Gaps = 79/613 (12%)
Query: 83 KIGSDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKE 142
K+ + L D + +W + ++LS S++++ D +E T + E+ K++
Sbjct: 1502 KLSPEEEMLQEDKKLKWEEWKQVWENMLSS--KSKEQQYKDEEEVTLEEEVSREGEEKEQ 1559
Query: 143 IHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLA 202
TE+Q + + + H+++ + ++K ++E+ K A +EK+ ++E+ LA
Sbjct: 1560 ---QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEER--KLAQEEEKLAQEERQ----LA 1610
Query: 203 KEQKKAKTA-----------EKSEEK--TKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKE 249
+E++K A ++E K K+E + EK+ Q A K+ + +K +K E
Sbjct: 1611 QEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWE 1670
Query: 250 KEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPAL 309
K +E+ ++K K + ++ K + P L ++ + L
Sbjct: 1671 KVAREEEKLAKKGGK--------LAEVKNILAQKVEELPQREQNLDWQEKE----LAQEL 1718
Query: 310 EEKEGEKKKAEKKVTSETKKKEK--EDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAA 367
EE E + ++ K +++ K E+ KK +E+E A+ +++ K SE + K+A
Sbjct: 1719 EELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQRE---KLSEEE---TKLAQ 1772
Query: 368 QAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKK-EKHVEPAKSPKKEHSVPSDKQVK--- 423
+ EK++ ++ +K E E+ G+K+E+ EK ++ A+ K+E + S +++
Sbjct: 1773 EEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQ--KRERWINSMEELTKNK 1830
Query: 424 ----AKTERAKEEIGAVSIKKAVPGKKE------EKTTKTVEQEIR-KEKSGKTSSILKD 472
K A+E+ K+ + +KE E+ T + +Q ++ K K G + IL
Sbjct: 1831 MILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQ 1890
Query: 473 KEPIKGKEEKVPASLKEKEPET------------KKDEKMSKAGKEVKPKPPQLQGKKEE 520
E +E++ KEK ET KK EK+++ ++ + +QGKK
Sbjct: 1891 VEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRL 1950
Query: 521 KPEPQIKKEAKPAISEKVQI--HKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKP 578
+ E I KE K E ++ K +V+ ++T+S G+ E +Q K +E+ +
Sbjct: 1951 RGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPE-TSRQRKMTQVEQELFERK 2009
Query: 579 TKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVST 638
E I + KG E T + + K +K + L +++ S
Sbjct: 2010 LSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKAS---RKLIKKRESL 2066
Query: 639 RKESLQLHNVTKA 651
KE +L+ + KA
Sbjct: 2067 SKEPAKLNKILKA 2079
Score = 82.4 bits (202), Expect = 1e-15
Identities = 119/563 (21%), Positives = 251/563 (44%), Gaps = 64/563 (11%)
Query: 139 RKKEIHKDKTEKQEKPERKIQTK--------VTHKEKEKGKEKVREKEKPEKKATHKEKI 190
+++++ + K + +K ER I + + +++K +EK ++ EK A KE +
Sbjct: 1801 KREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENL 1860
Query: 191 EKKEKPET---KTLAKEQKKA----KTAEKSEEKT--KKEVKGGKQEKVKQTAAKVKEVQ 241
++ T K L + + K K + EEK +KE K+EK+ +T K+ +V+
Sbjct: 1861 LYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVE 1920
Query: 242 KTPSKPKEK--EDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQA 299
+ +K +EK ++K K A+ K + + R +DI K ++ + E+
Sbjct: 1921 DSLAKKQEKLAQEKMKLALEKAMVQGKKRL-RGELDI-----AKEEKALNLEMKRLAEEK 1974
Query: 300 SRPTPASPALEEKEGEKKKAEKKVTS------ETKKKEKEDIKKKSEKETAIDVEKKEPG 353
R L + E + ++K+T E K +E I ++ A++ + G
Sbjct: 1975 MRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKG 2034
Query: 354 KASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKE 413
K T+ + + Q +K A+ + KK+E K EPAK K
Sbjct: 2035 KLEFTRGQRIFVQGQ---------------RKLAKASRKLIKKRESLSK--EPAKLNKIL 2077
Query: 414 HSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRK-EKSGKTSSILKD 472
++ K + + + +EEI +K+A+ K+ + + + +I++ + S K S + KD
Sbjct: 2078 KAL--QKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKD 2135
Query: 473 KEPIKGKEEKVPASLK----EKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIK- 527
++ + K+ K+ ++ ++E T+++ K+++ EV + G +EE+ P +K
Sbjct: 2136 EKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKR 2195
Query: 528 -----KEAKPAISEKVQIHKQ-DIVKPEKTVSHGKPE--EKVLKQVKAVTIEKTAKPKPT 579
KEAK K + Q D V+ E+ S +++ KQ + E+ + +
Sbjct: 2196 RWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEE 2255
Query: 580 KKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTR 639
++ E RE + ++ + K + E KKK + +KE ++ + +E++ +
Sbjct: 2256 EREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE 2315
Query: 640 KESLQLHNVTKAEKPARVSKDVE 662
+E+ L + + E+ + ++V+
Sbjct: 2316 EETESLSDEEEEEESCSLEEEVD 2338
Score = 75.9 bits (185), Expect = 1e-13
Identities = 125/594 (21%), Positives = 243/594 (40%), Gaps = 82/594 (13%)
Query: 141 KEIHKDKTEKQEKPERKIQTKVTHKEKEKGK---EKVREK----EKPEKKATHKEKIEKK 193
KEI K + +K + K K KE++ GK E +E+ E+ E+ AT +EK+ K+
Sbjct: 1385 KEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQ 1444
Query: 194 EKP----ETKTLAKEQKKAKTAEKSEE-KTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPK 248
E E ++ KKA K +T+K K K+E K+ + +++ + K
Sbjct: 1445 EGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLS 1504
Query: 249 EKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPA 308
+E+ + + ++K ++ + + + + K Q E+ SR
Sbjct: 1505 PEEE-----MLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREG----- 1554
Query: 309 LEEKEGEKKKAEKKVTSETK------KKEKEDIKKKSEKETAIDVEKKEPGKASETKQGT 362
EEKE + + ++ + E K K+ + + K+ E+ E+K + + Q
Sbjct: 1555 -EEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEE 1613
Query: 363 VKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQV 422
K+A + +E ++ K A+ E+ ++ EK + E +K+ + +K
Sbjct: 1614 RKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVA 1673
Query: 423 KAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEI---RKEKSGKTSSILKDKEPIKGK 479
+ + + AK+ +K + K EE + EQ + KE + + + D E + K
Sbjct: 1674 REEEKLAKKGGKLAEVKNILAQKVEELPQR--EQNLDWQEKELAQELEELEWDMEELSWK 1731
Query: 480 EEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQ 539
EE++ + E K E+ K +E + Q + EE E ++ +E + I EK +
Sbjct: 1732 EEEL------NQEEGKLVEEKKKLAEEEEALAWQREKLSEE--ETKLAQEEELLIQEKEK 1783
Query: 540 IHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSI-KTDKPK 598
+ + PE+ G+ E++++ K K A+ RER S+ + K K
Sbjct: 1784 LAQHKEKMPEEEERLGRKREQLIE-------------KKMKLAQKRERWINSMEELTKNK 1830
Query: 599 PTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHN----------- 647
+ + K + EK ++ K ++ + +E ++K+ +Q+ N
Sbjct: 1831 MILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQ 1890
Query: 648 ------------VTKAEKPARVSK---DVEDVPASKKAKEGTEDVSPTKQKSPI 686
+ K EK A K VED A K+ K E + +K+ +
Sbjct: 1891 VEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMV 1944
Score = 72.8 bits (177), Expect = 1e-12
Identities = 112/485 (23%), Positives = 220/485 (45%), Gaps = 66/485 (13%)
Query: 132 EIDEPPLRKKEIHKDKTEKQEKPERK---IQTKVTHKEKEKGKEKVR---EKE--KPEKK 183
+++E ++KE K EK + E+K ++ + K+++ +EK++ EK + +K+
Sbjct: 1890 QVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKR 1949
Query: 184 ATHKEKIEKKEKP---ETKTLAKEQKKAKTAEKSEEKTKKEV-KGGKQEKVKQTAAKVKE 239
+ I K+EK E K LA+E K + E E +K E + +Q K+ Q ++ E
Sbjct: 1950 LRGELDIAKEEKALNLEMKRLAEE--KMRLVEGKETLSKGETPETSRQRKMTQVEQELFE 2007
Query: 240 VQKT-PSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQ 298
+ + K ED+ A K + F R IFV G K + A + +
Sbjct: 2008 RKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQ-RIFVQGQRKLAK--ASRKLIKKRE 2064
Query: 299 ASRPTPAS-----PALEEKEGEKKKAEKKVTSETKKKEKEDIKKK--SEKETAIDVEKKE 351
+ PA AL++ +++K ++ TK K +K++ S +++ +D+++ +
Sbjct: 2065 SLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWD 2124
Query: 352 -PGKASETKQGTVKIAAQAAA---------KKDEK--KEDSKKTKKPAEV----EQPKGK 395
K SE + K+A + K+EK +E+SK +K +EV E+ G
Sbjct: 2125 FSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGI 2184
Query: 396 KQE----------KKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGK 445
++E +K K + PK++ S D E EE + ++ +
Sbjct: 2185 EEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVD-------EVESEEHFSEEMESLLDEL 2237
Query: 446 KEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGK 505
+++++ + E+E R+E+ + ++++E + +EE+ EKE E KK +K K +
Sbjct: 2238 EKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKE 2297
Query: 506 EVKPKPPQLQGKKE-------EKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPE 558
EV+ K + K+E E + ++E ++ E+V +++I+K EK +
Sbjct: 2298 EVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVD-REKEILKKEKQFKLQEQR 2356
Query: 559 EKVLK 563
K L+
Sbjct: 2357 RKSLR 2361
Score = 67.4 bits (163), Expect = 4e-11
Identities = 110/564 (19%), Positives = 243/564 (43%), Gaps = 37/564 (6%)
Query: 126 EDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKAT 185
ED +G E K+ + +++ + Q+K + + T +KGK+ + + P
Sbjct: 1326 EDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLE--PGNVTM 1383
Query: 186 HKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPS 245
KE +K+EK KT K K+ + A + E K K K+E K+ +EV++ +
Sbjct: 1384 GKEISKKEEK---KTFQKSPKQGRKAVQKERKVGKI----KREMTKEERDMSEEVEEMAT 1436
Query: 246 KPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIF--VHGDLKPG--------QSPAIPPPLP 295
+EK K++ + E+ + + D + VHG+ + + +
Sbjct: 1437 L-EEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEK 1495
Query: 296 TEQA-SRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGK 354
QA + +P L+E + K + K+V + ++ + K E+E ++ E G+
Sbjct: 1496 LHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGE 1555
Query: 355 ASETKQGTVKIAAQAAAKKDE-KKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKE 413
E + + Q K ++ ++ KK A+ E+ +++EK + +++
Sbjct: 1556 EKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERK 1615
Query: 414 HSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQ--EIRKEKSGKTSSILK 471
+ K + E A+ E G + K+ ++ EK ++ E+ + RK+ + K + +
Sbjct: 1616 LAQAYVKITQDDREMAQAE-GKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAR 1674
Query: 472 DKEPIK---GKEEKVPASLKEKEPE-TKKDEKMSKAGKEVKPKPPQLQGKKEEK--PEPQ 525
++E + GK +V L +K E ++++ + KE+ + +L+ EE E +
Sbjct: 1675 EEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEE 1734
Query: 526 IKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHR 585
+ +E + EK ++ +++ + + E K+ ++ + + EK K A+H+
Sbjct: 1735 LNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEK------EKLAQHK 1788
Query: 586 EREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQL 645
E+ P + K ++ + K++ I+ E K M +++ ++ K++L
Sbjct: 1789 EKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQ 1848
Query: 646 HNVTKAEKPARVSKDVEDVPASKK 669
A++ + + E + SKK
Sbjct: 1849 EKEKLAQRKENLLYNKERLTHSKK 1872
Score = 60.8 bits (146), Expect = 4e-09
Identities = 37/123 (30%), Positives = 78/123 (63%), Gaps = 7/123 (5%)
Query: 114 ISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEK 173
+SSE+EE+ + +E+ ++ E+ E ++E K++ E +EK K + + K+KEK KE+
Sbjct: 2243 LSSEEEEEREEEEEREEEEVRE----EEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEE 2298
Query: 174 VREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQT 233
V+EKE+ ++ KE+I +E+ E+ + +E++++ + E+ ++ K+ +K KQ K+++
Sbjct: 2299 VQEKEEVFEE---KEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQ 2355
Query: 234 AAK 236
K
Sbjct: 2356 RRK 2358
Score = 57.4 bits (137), Expect = 5e-08
Identities = 94/448 (20%), Positives = 189/448 (42%), Gaps = 48/448 (10%)
Query: 107 FSLLSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKE 166
FS D + SE+ ++ + D+ E +++ + ++ E++E+ E + + +V +E
Sbjct: 2213 FSSQVDEVESEEHFSEEMESLLDELE------KQESLSSEEEEEREEEEEREEEEVREEE 2266
Query: 167 KEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEE-KTKKEVKGG 225
+E+ +E+E+ E+K KE+ EKK+K + K + Q+K + E+ EE +++E +
Sbjct: 2267 EER-----KEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESL 2321
Query: 226 KQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIF---VHGDL 282
E+ ++ + ++E + KE KEK + +++ ++ I HG
Sbjct: 2322 SDEEEEEESCSLEE---EVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKG 2378
Query: 283 KPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKA-EKKVTSETKKKEKEDIKKKSEK 341
+ + + PL S ALE KE EK+++ E KK +I +K
Sbjct: 2379 RAIRLGVLKSPLKKLM-------STALEMKEKTPVPVPEKQISWEDKKATVVEIPRKF-- 2429
Query: 342 ETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKE 401
+D E++ GK + ++ A+ + S ++ E E+ + K
Sbjct: 2430 LGTMDKEREVMGKYEPIPPHVLGTVLESQAQDLKTPFMSHILRRTVEAEELQHKPLGAWW 2489
Query: 402 KHV--EPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIR 459
K P + E +P Q+ AK + A + V + V + E +++
Sbjct: 2490 KWFLQHPPLMGQTEVQLPL-SQIPAKEQHADVSLSDVEWIRHVLERME------AGEQLS 2542
Query: 460 KEKSGKTSSILKDKEPIKGKEEKVPASLKE----------KEPETKKDEKMSKAGKEVKP 509
++ + +LKD KG E + + E + +T+ + S + K +K
Sbjct: 2543 RDGFHRLCQLLKDLAS-KGNLEWLHLAKHEAIVYRHRQALESQDTRISSRQSMSPKYLKV 2601
Query: 510 KPPQLQGKKEEKPEPQIKKEAKPAISEK 537
PP +KE P+P K ++ K
Sbjct: 2602 IPPIKAKEKESWPKPLAVPTQKSPLATK 2629
Score = 53.1 bits (126), Expect = 9e-07
Identities = 90/456 (19%), Positives = 198/456 (43%), Gaps = 75/456 (16%)
Query: 293 PLPTEQASRPTPASPALEE-----KEGEK----------------KKAEKKVTSETKKKE 331
P EQA + LEE K+G+K KK EKK ++ K+
Sbjct: 1344 PREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQG 1403
Query: 332 KEDIKK------------KSEKETAIDVEKKEPGKASETKQ-GTVKIAAQAAAKKDEKKE 378
++ ++K K E++ + +VE+ + KQ G + + + + +D KK
Sbjct: 1404 RKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKA 1463
Query: 379 ---------DSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQV------- 422
+++K+ K + E K QE+++ H K +E + DK++
Sbjct: 1464 WDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQ 1523
Query: 423 --------KAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDK- 473
K+K ++ K+E V++++ V + EEK + E++ ++ K + I + +
Sbjct: 1524 VWENMLSSKSKEQQYKDE-EEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRA 1582
Query: 474 --EPIKGKEEKVPASLKEKEPE-----TKKDEKMSKAGKEVKP---KPPQLQGKKEEKPE 523
E + +EE+ A +EK + +++ K+++A ++ + Q +GK +K E
Sbjct: 1583 RAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEE 1642
Query: 524 PQIKK-EAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKA 582
++ E +EK+ ++ + K + V+ + EEK+ K+ + K + ++
Sbjct: 1643 TLAQRGEKLSQEAEKLAQKRKKLAKKWEKVA--REEEKLAKKGGKLAEVKNILAQKVEEL 1700
Query: 583 EHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEK--VSTRK 640
RE+ + + + + ++ E K+ E++++E K + K L EE+ ++ ++
Sbjct: 1701 PQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQR 1760
Query: 641 ESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTED 676
E L A++ + ++ E + K+ E+
Sbjct: 1761 EKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEE 1796
Score = 45.4 bits (106), Expect = 2e-04
Identities = 85/404 (21%), Positives = 156/404 (38%), Gaps = 41/404 (10%)
Query: 237 VKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPT 296
V E + KP + + + +A V KH QK ++ + + Q P L
Sbjct: 1068 VSEESEVAIKPSKGQRRGQAGVKKHSQK-------WLRGLKKTKERDSKQMSTEPGLLED 1120
Query: 297 EQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKK--SEKETAIDVEKKEPGK 354
E + P +E +E TS K + D ++K S+ A+ +++ + +
Sbjct: 1121 ESGTEAAP----IEMEEASVYSQWSSSTSVIKLSKDVDSQEKDISKDHIALTLKRLQKIR 1176
Query: 355 ASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKK---QEKKEKHVEPAKSPK 411
K+ T + + KK ++ + + P +EQP KK Q + + +S
Sbjct: 1177 DKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKKVKIQGRGASGISGRRSTA 1236
Query: 412 KEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILK 471
+ S D + R + S K E T E + + S + + +
Sbjct: 1237 GDGSSWRDDLCRLMALRI-----SGSQTKMSENLNAELVTFAQEMLVDRHPSWE---LFQ 1288
Query: 472 DKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAK 531
+ P+ KE KV L++ + + EK +E + +QG +E KE
Sbjct: 1289 EICPLLKKESKV--LLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIR---HKEVM 1343
Query: 532 PAISEKVQIHKQDIVKPEKTVSHGKPEEKVL----------KQVKAVTIEKT--AKPKPT 579
P E+ Q +D++ E+T K +KV+ K++ +KT PK
Sbjct: 1344 PREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQG 1403
Query: 580 KKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESK 623
+KA +ER+ IK + K + EV E + ++ ++E K
Sbjct: 1404 RKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGK 1447
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 82.4 bits (202), Expect = 1e-15
Identities = 85/422 (20%), Positives = 210/422 (49%), Gaps = 56/422 (13%)
Query: 130 KGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEK 189
+ +++E L + +++ + EK + E KIQ ++ ++ +EK+RE+E EK +EK
Sbjct: 282 QAQVEENELWNR-LNQQQEEKMWRQEEKIQE--WEEKIQEQEEKIREQE--EKIREQEEK 336
Query: 190 IEKKEKPETKTLAKEQKKAKTAEKSEEKTKK--EVKGGKQEKVKQTAAKVKEVQKTPSKP 247
+ ++E+ + K +++ + + EEK ++ E+ K+EK+++ K+ E +K +
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQE 396
Query: 248 KEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASP 307
++++++EK + ++K Q EQ ++
Sbjct: 397 EKRQEEEKI---REQEKRQ------------------------------EQEAKMWRQEE 423
Query: 308 ALEEKEGEKKKAEKKV-TSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIA 366
+ E+E + ++ EKK+ E K E+E I+++ +++ E++E + E + +I
Sbjct: 424 KIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQ-----EQEEMWRQEEKIREQEEIW 478
Query: 367 AQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKT 426
Q +K ++E +K ++ ++ K QE+K + E ++E +++++ +
Sbjct: 479 RQ--KEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQE 536
Query: 427 ERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEK-SGKTSSILKDKEPIKGKEEKVPA 485
E+ +E+ + ++ G++EEK + + ++EK + I + KE I+ +EEK+
Sbjct: 537 EKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKI-- 594
Query: 486 SLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEK---PEPQIKKEAKPAISEKVQIHK 542
E+E + ++ E+M + +E + + ++EEK E +++++ + ++V++ +
Sbjct: 595 --WEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 652
Query: 543 QD 544
Q+
Sbjct: 653 QE 654
Score = 77.8 bits (190), Expect = 3e-14
Identities = 94/498 (18%), Positives = 229/498 (45%), Gaps = 49/498 (9%)
Query: 142 EIHKDKTEKQEKPER--KIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKE-KPET 198
E++++ +E E+ K+Q K+ E EK + ++ KE K K + +++ + E
Sbjct: 208 ELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEA 267
Query: 199 KTLAKEQKKAKT---AEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEK 255
L KE + A+ E + + ++EK+ + K++E ++ + +EK +++
Sbjct: 268 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327
Query: 256 AAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGE 315
+ + E+K R ++ + K + + E+ + + EKE +
Sbjct: 328 EKIREQEEK-----MRRQEEMMWEKEEKMRRQEE----MMWEKEEKMRRLEEMMWEKEEK 378
Query: 316 KKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDE 375
++ E+K+ + K +E+E+ K+ E+E + EK++ +A +Q KI Q +++
Sbjct: 379 IRELEEKMHEQEKIREQEE--KRQEEEKIREQEKRQEQEAKMWRQ-EEKIREQEEKIREQ 435
Query: 376 KKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGA 435
+K+ ++ +K E E K ++EK E + ++E + +++ + E+ E
Sbjct: 436 EKKMWRQEEKIHEQE-----KIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHE---- 486
Query: 436 VSIKKAVPGKKEEKTTKTVEQEIRKEKS--GKTSSILKDKEPIKGKEEKVPASLKEKEPE 493
+EK K E+ R+E+ + I + +E + +EEK+ +E+E +
Sbjct: 487 -----------QEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKI----REQEEK 531
Query: 494 TKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVS 553
++ E+ + +E+ + + G++EEK + Q K + EK++ ++ I + ++ +
Sbjct: 532 IREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQ---EEKIREQEEKIREQKEKIR 588
Query: 554 HGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKK 613
+ EEK+ +Q + + ++ + +K +E + + + K + + ++
Sbjct: 589 --EQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 646
Query: 614 KTEISEKESKEKADMKHL 631
+ + ++E K + +HL
Sbjct: 647 EVRLRQQEEKMQEHQEHL 664
Score = 75.1 bits (183), Expect = 2e-13
Identities = 97/502 (19%), Positives = 227/502 (45%), Gaps = 37/502 (7%)
Query: 184 ATHKEK----IEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKE 239
AT K+K IE+ K + + T E+ +EK K QEK++ ++ E
Sbjct: 185 ATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK-----LQEKLQLVESEKSE 239
Query: 240 VQKTPSKPKEKEDKEKAAVSKHE---QKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPT 296
+Q + K K ++ K + + + + D + + ++ + + L
Sbjct: 240 IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENE---LWNRLNQ 296
Query: 297 EQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKK-----E 351
+Q + ++E E + ++ E+K+ + +K +++ K + ++E + E+K E
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE 356
Query: 352 PGKASETKQGTVKIAAQAAAKK----DEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPA 407
E K ++ +K +EK + +K ++ E Q + K +E++++ + A
Sbjct: 357 MMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 416
Query: 408 KSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTS 467
K ++E + +++ K + + K I + ++EEK + E ++EK +
Sbjct: 417 KMWRQEEKI-REQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQE 475
Query: 468 SILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIK 527
I + KE + ++EK+ K++E +++EKM ++++ Q +K + E +I+
Sbjct: 476 EIWRQKEKMH-EQEKI---RKQEEKVWRQEEKMHDQEEKIRE-----QEEKMWRQEEKIR 526
Query: 528 KEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHRE- 586
++ + ++ +I +Q+ + E+ G+ EEK+ +Q K E+ + + K E +E
Sbjct: 527 EQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEK 586
Query: 587 -REPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQL 645
RE ++ + + + E +K E EK +++ M+ +EEK+ ++E +
Sbjct: 587 IREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE-QEEKMRRQEEKMWE 645
Query: 646 HNVTKAEKPARVSKDVEDVPAS 667
V ++ ++ + E + A+
Sbjct: 646 QEVRLRQQEEKMQEHQEHLEAA 667
Score = 65.1 bits (157), Expect = 2e-10
Identities = 75/378 (19%), Positives = 176/378 (46%), Gaps = 48/378 (12%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVRE 176
+++E+ +++ E +E R++E+ +K EK + E + EKE+ ++ E
Sbjct: 317 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW------EKEEKMRRLEE 370
Query: 177 K--EKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGK----QEKV 230
EK EK +EK+ ++EK +E+K+ + EK E+ K++ + K +EK+
Sbjct: 371 MMWEKEEKIRELEEKMHEQEKIRE----QEEKR-QEEEKIREQEKRQEQEAKMWRQEEKI 425
Query: 231 KQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAI 290
++ K++E +K + +EK +++ + ++++Q R
Sbjct: 426 REQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR------------------- 466
Query: 291 PPPLPTEQASRPTPASPALEEKEGEK---KKAEKKVTSETKKKEKEDIKKKSEKETAIDV 347
E+ R +EK E+ +K E+KV + +K ++ K + ++E
Sbjct: 467 -----QEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQ 521
Query: 348 EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPA 407
E+K + + ++ KI Q ++++++ ++ +K EQ K ++QE+K + E
Sbjct: 522 EEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQ--EQEKMRRQEEKIREQEEK 579
Query: 408 KSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVE--QEIRKEKSGK 465
+KE ++++ + E+ +E+ + ++ ++EEK + E QE ++ +
Sbjct: 580 IREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 639
Query: 466 TSSILKDKEPIKGKEEKV 483
+ + + ++ +EEK+
Sbjct: 640 EEKMWEQEVRLRQQEEKM 657
Score = 56.6 bits (135), Expect = 8e-08
Identities = 79/395 (20%), Positives = 169/395 (42%), Gaps = 49/395 (12%)
Query: 308 ALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAA 367
AL +KKKA++ + TK E++ + + + T D E KE
Sbjct: 180 ALSAVATQKKKADRYIEELTK--ERDALSLELYRNTITDEELKEKN-------------- 223
Query: 368 QAAAKKDEKKE--DSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAK 425
AK EK + +S+K++ V++ K K + K + + +H + V AK
Sbjct: 224 ---AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 280
Query: 426 TERAKEEIGAVSIKKAVPGKKEEKTTKTVE--QEIRKEKSGKTSSILKDKEPIKGKEEKV 483
+ EE + + ++EEK + E QE ++ + I + +E I+ +EEK+
Sbjct: 281 LQAQVEEN---ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM 337
Query: 484 ---PASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEK--------PEPQIKKEAKP 532
+ EKE + ++ E+M +E + ++ +KEEK E + +E +
Sbjct: 338 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEE 397
Query: 533 AISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSI 592
E+ +I +Q+ + E+ + EEK+ +Q + + ++ + +K +E+
Sbjct: 398 KRQEEEKIREQE-KRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE 456
Query: 593 KTDKPKPTPKGTSEVTES---GKKKTEISEKESKEKADMK--------HLREEKVSTRKE 641
K + + + ++ E ++K ++ E+E K + K H +EEK+ ++E
Sbjct: 457 KRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEE 516
Query: 642 SLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTED 676
+ E+ ++ + E + ++ + E+
Sbjct: 517 KMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEE 551
Score = 48.5 bits (114), Expect = 2e-05
Identities = 40/159 (25%), Positives = 85/159 (53%), Gaps = 11/159 (6%)
Query: 119 EEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKI--QTKVTHKEKEKGKEKVRE 176
+E+ D++ E +E R++E +++ EK + E KI Q ++ +++EK E+ +
Sbjct: 500 QEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEK 559
Query: 177 KEKPEKKATHKEKIEKKEKP--ETKTLAKEQ------KKAKTAEKSEEKTKKEVKGGKQ- 227
++ EK +EKI ++E+ E K +EQ ++ K E+ E ++E K +Q
Sbjct: 560 MQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQE 619
Query: 228 EKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQ 266
EK+ + K++E ++ + +EK +++ + + E+K Q
Sbjct: 620 EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 658
Score = 43.1 bits (100), Expect = 0.001
Identities = 35/139 (25%), Positives = 76/139 (54%), Gaps = 10/139 (7%)
Query: 113 IISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKE 172
I E++ + ++ ++ E+ + K ++K ++QEK R+ + K+ +E++ ++
Sbjct: 525 IREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQ-EEKIREQEEKIREQ 583
Query: 173 KVREKEKPEKKATHKEKIEKKE----KPETKTLAKEQKKAKTAEKSEEKTKK----EVKG 224
K + +E+ EK +EKI ++E + E K +E+K + EK +E+ +K E K
Sbjct: 584 KEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM 643
Query: 225 GKQE-KVKQTAAKVKEVQK 242
+QE +++Q K++E Q+
Sbjct: 644 WEQEVRLRQQEEKMQEHQE 662
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 82.0 bits (201), Expect = 2e-15
Identities = 103/466 (22%), Positives = 187/466 (40%), Gaps = 47/466 (10%)
Query: 193 KEKPETKTLAKEQK-KAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKE 251
+E+PE + E+ + E SE++++ + K++K K + K K+ + + + K+K+
Sbjct: 10 REQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRS-KHKKHKHSSEEDKDKK 68
Query: 252 DKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEE 311
K K KH++K+ + K G SPA L AL +
Sbjct: 69 HKHKHKHKKHKRKE-----------IIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIK 117
Query: 312 KEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAA 371
E + + E KV S + + SE+E I EK G S T+ + K +
Sbjct: 118 AELDNELMEGKVQS-GMGLILQGYESGSEEEGEIH-EKARNGNRSSTRSSSTKGKLELVD 175
Query: 372 KKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKE 431
K K+ SK K E+ + + +KK K + VK KT R+K
Sbjct: 176 NKITTKKRSKSRSK----ERTRHRSDKKKSK--------------GGIEIVKEKTTRSKS 217
Query: 432 EIGAVSIKKAVPGKKEEKTTKTVEQEIRK---EKSGKTSSILKDKEPIKGKEEKVPASLK 488
+ S + K +++ K+ +R+ EK GK S DK I+ K + K
Sbjct: 218 KERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIEDKSKS-----K 272
Query: 489 EKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKP 548
+++ +E S+ + P L+GK +++ ++++K + ++K K+ I P
Sbjct: 273 DRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDK---EKKPIKSP 329
Query: 549 EKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVT 608
K S GK ++ ++ PKP K+ R R P + D+ K S
Sbjct: 330 SKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKS-RRSRSP--LLNDRRSKQSKSPSRTL 386
Query: 609 ESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKP 654
G++ S + + + + + L + R + L +K P
Sbjct: 387 SPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASP 432
Score = 69.3 bits (168), Expect = 1e-11
Identities = 99/558 (17%), Positives = 210/558 (37%), Gaps = 62/558 (11%)
Query: 129 DKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATH-- 186
++GEI E + + K E + K+T K++ K + K R + + +KK +
Sbjct: 146 EEGEIHEKARNGNRSSTRSSSTKGKLEL-VDNKITTKKRSKSRSKERTRHRSDKKKSKGG 204
Query: 187 ----KEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQK 242
KEK + + E K K++K+ +++ + ++ QEK+ + + + K
Sbjct: 205 IEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVK 264
Query: 243 TPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRP 302
K K K+ K+ +++ +D+ R +D+ G K +S
Sbjct: 265 IEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDL--RGKSKDRRS--------------- 307
Query: 303 TPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGT 362
KE + K++E + K +D E + + PG++ + + +
Sbjct: 308 -------RSKERKSKRSETDKEKKPIKSPSKDASSGKENRS----PSRRPGRSPKRRSLS 356
Query: 363 VKIAAQAAAKKDEKKED--SKKTKKPAEVEQP--KGKKQEKKEKHVEPAKSPKKEHSVPS 418
K ++ + D SK++K P+ P + K + + K EP +
Sbjct: 357 PKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRP 416
Query: 419 DKQVKAKTERAKEEIGAVSIKKAVPGKKEEKT--TKTVEQEIRKEKSGKTSSILKDKEPI 476
+ ++ ER+K+ A I + P ++ ++ + +R+ +S + S +
Sbjct: 417 RDDILSRRERSKD---ASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRS-RSPRRRD 472
Query: 477 KGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEP--------QIKK 528
+G+ + + + ++ SK KE K K +G K E+ +++
Sbjct: 473 RGRRSRSRLRRRSRSRGGRRRRSRSKV-KEDKFKGSLSEGMKVEQESSSDDNLEDFDVEE 531
Query: 529 EAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHRERE 588
E + A+ E+ +I +Q IV+ K ++ + + +T P P E
Sbjct: 532 EDEEALIEQRRIQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSPDDILER---- 587
Query: 589 PPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNV 648
+ D + + S K K + E + K L + T + +
Sbjct: 588 ---VAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKLLAPDMFTESDDMFAAYF 644
Query: 649 TKAE-KPARVSKDVEDVP 665
A + A + KD ++ P
Sbjct: 645 DSARLRAAGIGKDFKENP 662
Score = 67.4 bits (163), Expect = 4e-11
Identities = 111/603 (18%), Positives = 223/603 (36%), Gaps = 67/603 (11%)
Query: 114 ISSEDEEDDDGDEDT---DKGEIDEPPLRKKEI-HKDKTEKQEKPERKIQTKVTHK-EKE 168
+ + E +D E + + GE+ E + K HK K K +K HK E
Sbjct: 9 LREQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKK------HKHSSE 62
Query: 169 KGKEKVREKEKPEKKATHKEKIEKKEK----PETKTLAKEQKKAKTAEKSEEKTKKEVKG 224
+ K+K + + KK KE I+ +K P +T + + EK K E+
Sbjct: 63 EDKDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDN 122
Query: 225 GKQE-KVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLK 283
E KV+ + + ++ S+ +E E EKA
Sbjct: 123 ELMEGKVQSGMGLILQGYESGSE-EEGEIHEKARNGNRSS--------------TRSSST 167
Query: 284 PGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSE--TKKKEKEDIKKKSEK 341
G+ + + T++ S+ + +K K ++ E T+ K KE K KS
Sbjct: 168 KGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPS 227
Query: 342 ETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEK-----KEDSKKTKKPAEVEQPKGKK 396
+ + ++ K+ ++ + + +A + D+K K SK KK + + + +
Sbjct: 228 KRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRD 287
Query: 397 QEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKT------ 450
+ KK + + K+ S ++ ++E KE+ S K KE ++
Sbjct: 288 RGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPG 347
Query: 451 ----TKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVP---------ASLKEKEPETKKD 497
+++ + R + S +L D+ + K+ K P A + E + ++
Sbjct: 348 RSPKRRSLSPKPRDKSRRSRSPLLNDR---RSKQSKSPSRTLSPGRRAKSRSLERKRREP 404
Query: 498 EKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKP 557
E+ + +P+ L ++ K I + + + I ++ ++ S +
Sbjct: 405 ERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRR 464
Query: 558 EEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEI 617
++ + + + + R R +K DK K ++E K + E
Sbjct: 465 SRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKEDKFK------GSLSEGMKVEQES 518
Query: 618 SEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSK-DVEDVPASKKAKEGTED 676
S ++ E D++ EE + ++ + V K + A S V P+S ++ T
Sbjct: 519 SSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRS 578
Query: 677 VSP 679
SP
Sbjct: 579 PSP 581
Score = 55.1 bits (131), Expect = 2e-07
Identities = 71/335 (21%), Positives = 135/335 (40%), Gaps = 34/335 (10%)
Query: 374 DEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDK------QVKAKTE 427
+ +K +++ + +E + + KK+KH +K K +HS DK + K K
Sbjct: 19 NSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDKDKKHKHKHKHKKH 78
Query: 428 RAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEK----V 483
+ KE I A + P K+ + + +++ K+++ + + D E ++GK + +
Sbjct: 79 KRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAEL--DNELMEGKVQSGMGLI 136
Query: 484 PASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQ 543
+ E + + ++ G + +GK E K+ + S++ H+
Sbjct: 137 LQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRS 196
Query: 544 D---------IVKPEKTVSHGKPEEKVLKQVKAVTIE----KTAKPKPTKKAEHREREPP 590
D IVK + T S K +K K + K+ P ++++ + +
Sbjct: 197 DKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKAR 256
Query: 591 SIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTK 650
S DK K K S + KK I+E S+++ V R +S + +K
Sbjct: 257 SPTDDKVKIEDKSKS---KDRKKSPIINESRSRDRGKKS---RSPVDLRGKSKDRRSRSK 310
Query: 651 AEKPARVSKDVEDVP---ASKKAKEGTEDVSPTKQ 682
K R D E P SK A G E+ SP+++
Sbjct: 311 ERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRR 345
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 81.3 bits (199), Expect = 3e-15
Identities = 83/424 (19%), Positives = 206/424 (48%), Gaps = 54/424 (12%)
Query: 130 KGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEK 189
+ +++E L + +++ + EK + E KIQ ++ ++ +EK+RE+E EK +EK
Sbjct: 343 QAQVEENELWNR-LNQQQEEKMWRQEEKIQE--WEEKIQEQEEKIREQE--EKIREQEEK 397
Query: 190 IEKKEKPETKTLAKEQKKAKTAEKSEEKTKK--EVKGGKQEKVKQTAAKVKEVQKTPSKP 247
+ ++E+ + K +++ + + EEK ++ E+ K+EK+++ K+ E +K +
Sbjct: 398 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE 457
Query: 248 KEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASP 307
++++++EK + Q+ + R I EQ +
Sbjct: 458 EKRQEEEKIREQEKRQEQEAKMWRQEEKI-------------------REQEEKIREQEE 498
Query: 308 ALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAA 367
+ +E EK ++K+ E K++E+E++ ++ EK E++E + E
Sbjct: 499 KMWRQE-EKIHEQEKIREEEKRQEQEEMWRQEEKIR----EQEEIWRQKE---------- 543
Query: 368 QAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTE 427
K E++E +K ++ ++ K QE+K + E ++E +++++ + E
Sbjct: 544 ----KIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEE 599
Query: 428 RAKEEIGAVSIKKAVPGKKEEKTTKTVE--QEIRKEKSGKTSSILKDKEPIKGKEEKV-- 483
+ +E+ ++ G++EEK + E QE ++ + I + ++ I+ +EEK+
Sbjct: 600 KIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 659
Query: 484 --PASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIH 541
+++E +++EKM + ++++ + +++ ++E+ E +++ + EK+Q H
Sbjct: 660 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ---EEKMQEH 716
Query: 542 KQDI 545
++ +
Sbjct: 717 QEHL 720
Score = 74.7 bits (182), Expect = 3e-13
Identities = 99/532 (18%), Positives = 235/532 (44%), Gaps = 83/532 (15%)
Query: 142 EIHKDKTEKQEKPER--KIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKE-KPET 198
E++++ +E E+ K+Q K+ E EK + ++ KE K K + +++ + E
Sbjct: 269 ELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEA 328
Query: 199 KTLAKEQKKAKT---AEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEK 255
L KE + A+ E + + ++EK+ + K++E ++ K +E+E+K
Sbjct: 329 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEE---KIQEQEEK-- 383
Query: 256 AAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGE 315
+ + E+K + EQ + + EKE +
Sbjct: 384 --IREQEEKIR------------------------------EQEEKMRRQEEMMWEKEEK 411
Query: 316 KKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDE 375
++ E+ + EKE+ K + ++E + E+K + +E
Sbjct: 412 MRRQEEMMW------EKEE-KMRRQEEMMWEKEEK-------------------IRELEE 445
Query: 376 KKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGA 435
K + +K ++ E Q + K +E++++ + AK ++E + +++ K + + K
Sbjct: 446 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI-REQEEKIREQEEKMWRQE 504
Query: 436 VSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETK 495
I + ++EEK + E ++EK + I + KE I +EEK+ K++E +
Sbjct: 505 EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKI---RKQEEKMWR 561
Query: 496 KDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHG 555
++EKM ++++ Q +K + E +I+++ + ++ +I +Q+ + E+ G
Sbjct: 562 QEEKMHDQEEKIRE-----QEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMG 616
Query: 556 KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKT 615
+ EEK+ +Q + + ++ + +K +E+ K + + + E+ + ++K
Sbjct: 617 EQEEKMCEQEEKMQEQEEKMRRQEEKIREQEK-----KIREQEEKIREQEEMMQEQEEKM 671
Query: 616 EISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPAS 667
E++ E+ + +EEK+ ++E + V ++ ++ + E + A+
Sbjct: 672 WEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 723
Score = 65.9 bits (159), Expect = 1e-10
Identities = 67/374 (17%), Positives = 174/374 (46%), Gaps = 45/374 (12%)
Query: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVRE 176
+++E+ +++ E +E R++E+ +K EK + E + EK ++ R+
Sbjct: 378 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW--------EKEEKMRRQ 429
Query: 177 K----EKPEKKATHKEKIEKKEK-PETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVK 231
+ EK EK +EK+ ++EK E + +E++K + EK +E+ K + ++EK++
Sbjct: 430 EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR--QEEKIR 487
Query: 232 QTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIP 291
+ K++E ++ + +EK +++ + ++++Q R I
Sbjct: 488 EQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI--------------- 532
Query: 292 PPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKE 351
+ + E+E + +K E+K+ + +K ++ K + ++E E+K
Sbjct: 533 -----REQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKI 587
Query: 352 PGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPK 411
+ + ++ KI Q ++++++ ++ +K E E+ +++EK + E +
Sbjct: 588 REQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIRE-- 645
Query: 412 KEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVE--QEIRKEKSGKTSSI 469
+K+++ + E+ +E+ + ++ ++EEK + E QE ++ + +
Sbjct: 646 ------QEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM 699
Query: 470 LKDKEPIKGKEEKV 483
+ + ++ +EEK+
Sbjct: 700 WEQEVRLRQQEEKM 713
Score = 64.3 bits (155), Expect = 4e-10
Identities = 60/282 (21%), Positives = 141/282 (50%), Gaps = 28/282 (9%)
Query: 134 DEPPLRKKEIHKDKTEKQEKPERKI---QTKVTHKEKE--KGKEKVREKEK--PEKKATH 186
+E +R++E +++ K + E KI + K+ +E++ + +EK+ E+EK E+K
Sbjct: 462 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQE 521
Query: 187 KEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQ-EKVKQTAAKVKEVQKTPS 245
+E++ ++E+ + ++K K E+ E+ K+E K +Q EK+ K++E ++
Sbjct: 522 QEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVW 581
Query: 246 KPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPA 305
+ +EK +++ + + E+K R ++ + K G EQ +
Sbjct: 582 RQEEKIREQEEKIREQEEK-----IREQEEMTQEQEEKMG-----------EQEEKMCEQ 625
Query: 306 SPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKI 365
++E+E + ++ E+K+ + KK +++ K + ++E + E+K + + + K+
Sbjct: 626 EEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 685
Query: 366 AAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPA 407
Q ++ ++++ K ++ + Q + K QE +E H+E A
Sbjct: 686 QEQ---EEKMRRQEEKMWEQEVRLRQQEEKMQEHQE-HLEAA 723
Score = 50.1 bits (118), Expect = 7e-06
Identities = 36/154 (23%), Positives = 89/154 (57%), Gaps = 7/154 (4%)
Query: 119 EEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKI--QTKVTHKEKEK-GKEKVR 175
+E+ D++ E +E R++E +++ EK + E KI Q ++T +++EK G+++ +
Sbjct: 562 QEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEK 621
Query: 176 EKEKPEKKATHKEKI---EKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQ 232
E+ EK +EK+ E+K + + K + ++++K + E+ ++ ++E ++EK+ +
Sbjct: 622 MCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE-QEEKMWEQEEKMCE 680
Query: 233 TAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQ 266
K++E ++ + +EK +++ + + E+K Q
Sbjct: 681 QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 714
Score = 43.5 bits (101), Expect = 7e-04
Identities = 69/366 (18%), Positives = 155/366 (42%), Gaps = 92/366 (25%)
Query: 308 ALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAA 367
AL +KKKA++ + TK E++ + + + T D E KE
Sbjct: 241 ALSAVATQKKKADRYIEELTK--ERDALSLELYRNTITDEELKEKN-------------- 284
Query: 368 QAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTE 427
AK EK + + K ++ + K++ ++ K + P +Q++A+ +
Sbjct: 285 ---AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP------------QQQLQAEAD 329
Query: 428 RAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASL 487
+E+ +VS K ++ E + +Q+ K + + +E I+ EEK+
Sbjct: 330 HLGKELQSVSAKLQAQVEENELWNRLNQQQEEK--------MWRQEEKIQEWEEKI---- 377
Query: 488 KEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVK 547
+E+E + ++ E+ + +E + ++ +KEEK ++++ + ++ ++ +Q+ +
Sbjct: 378 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEK----MRRQEEMMWEKEEKMRRQEEMM 433
Query: 548 PEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEV 607
EK + EEK+ +Q K RE+E
Sbjct: 434 WEKEEKIRELEEKMHEQEKI-----------------REQE------------------- 457
Query: 608 TESGKKKTEISEKESKEKADMKHLR-EEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPA 666
E +++ +I E+E +++ + K R EEK+ ++E ++ E+ ++ + E +
Sbjct: 458 -EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR-------EQEEKMWRQEEKIHE 509
Query: 667 SKKAKE 672
+K +E
Sbjct: 510 QEKIRE 515
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/132 (25%), Positives = 73/132 (55%), Gaps = 9/132 (6%)
Query: 118 DEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREK 177
++E+ +++ E +E ++E ++ EK + E K+Q + ++ + +EK+RE+
Sbjct: 589 EQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ--EEKMRRQEEKIREQ 646
Query: 178 EKP--EKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKK----EVKGGKQE-KV 230
EK E++ +E+ E ++ E K +E+K + EK +E+ +K E K +QE ++
Sbjct: 647 EKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 706
Query: 231 KQTAAKVKEVQK 242
+Q K++E Q+
Sbjct: 707 RQQEEKMQEHQE 718
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.300 0.121 0.319
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,767,638
Number of Sequences: 37866
Number of extensions: 1916331
Number of successful extensions: 59273
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 822
Number of HSP's successfully gapped in prelim test: 1787
Number of HSP's that attempted gapping in prelim test: 13837
Number of HSP's gapped (non-prelim): 17734
length of query: 729
length of database: 18,247,518
effective HSP length: 110
effective length of query: 619
effective length of database: 14,082,258
effective search space: 8716917702
effective search space used: 8716917702
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.