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Search of human proteins with 10440566
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10440566 leucine zipper, putative tumor suppressor 1 [Homo
sapiens]
(596 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10440566 leucine zipper, putative tumor suppressor 1 [Homo sa... 1172 0.0
gi|45331215 leucine zipper, putative tumor suppressor 2 [Homo sa... 314 1e-85
gi|7662176 ProSAPiP1 protein [Homo sapiens] 302 7e-82
gi|62177129 Nedd4 binding protein 3 [Homo sapiens] 152 1e-36
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 77 4e-14
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 77 4e-14
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 77 4e-14
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 77 4e-14
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 77 4e-14
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 77 4e-14
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 77 4e-14
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 77 4e-14
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 76 1e-13
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 76 1e-13
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 73 6e-13
gi|239745114 PREDICTED: Golgin subfamily A member 8-like protein... 73 8e-13
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 72 1e-12
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 72 1e-12
gi|239745147 PREDICTED: similar to Golgin subfamily A member 8-l... 72 2e-12
gi|239745111 PREDICTED: Golgin subfamily A member 8-like protein... 72 2e-12
gi|239745099 PREDICTED: similar to Golgin subfamily A member 8-l... 72 2e-12
gi|239745130 PREDICTED: similar to Golgin subfamily A member 8-l... 70 4e-12
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 70 5e-12
gi|195947367 golgi autoantigen, golgin subfamily a, 8B [Homo sap... 69 2e-11
gi|31083099 golgi autoantigen, golgin subfamily a, 8A [Homo sapi... 69 2e-11
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 69 2e-11
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 69 2e-11
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 68 2e-11
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 68 2e-11
gi|42794779 myosin 18A isoform b [Homo sapiens] 68 3e-11
>gi|10440566 leucine zipper, putative tumor suppressor 1 [Homo
sapiens]
Length = 596
Score = 1172 bits (3033), Expect = 0.0
Identities = 596/596 (100%), Positives = 596/596 (100%)
Query: 1 MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMG 60
MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMG
Sbjct: 1 MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMG 60
Query: 61 KSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSEKG 120
KSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSEKG
Sbjct: 61 KSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSEKG 120
Query: 121 AVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMS 180
AVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMS
Sbjct: 121 AVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMS 180
Query: 181 SLPTHSTSSSYQLDPLVTPVGPTSRFGGSAHNITQGIVLQDSNMMSLKALSFSDGGSKLG 240
SLPTHSTSSSYQLDPLVTPVGPTSRFGGSAHNITQGIVLQDSNMMSLKALSFSDGGSKLG
Sbjct: 181 SLPTHSTSSSYQLDPLVTPVGPTSRFGGSAHNITQGIVLQDSNMMSLKALSFSDGGSKLG 240
Query: 241 HSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPR 300
HSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPR
Sbjct: 241 HSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPR 300
Query: 301 RCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLE 360
RCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLE
Sbjct: 301 RCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLE 360
Query: 361 TKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLK 420
TKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLK
Sbjct: 361 TKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLK 420
Query: 421 DTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRA 480
DTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRA
Sbjct: 421 DTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRA 480
Query: 481 QAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVI 540
QAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVI
Sbjct: 481 QAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVI 540
Query: 541 QYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIATEI 596
QYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIATEI
Sbjct: 541 QYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIATEI 596
>gi|45331215 leucine zipper, putative tumor suppressor 2 [Homo
sapiens]
Length = 669
Score = 314 bits (805), Expect = 1e-85
Identities = 243/658 (36%), Positives = 320/658 (48%), Gaps = 76/658 (11%)
Query: 1 MGSVSSLISGHSFHSKHCRASQYKLRKSSHL-KKLNRYSDGLLRFGFSQDSG--HGKSSS 57
MGSVSSLISG + C R R DGLLR G+
Sbjct: 26 MGSVSSLISG-----RPCPGGPAPPRHHGPPGPTFFRQQDGLLRGGYEAQEPLCPAVPPR 80
Query: 58 KMGKSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGS 117
K F YI + P + + P PPKL+P S +LE
Sbjct: 81 KAVPVTSFTYINEDFRTESPPSPSSDVEDAREQRAHNAHLRGP--PPKLIPVSGKLEKNM 138
Query: 118 EKGAVRPTAFKPVLPR------------------SGA------ILHSSPESASHQLHPAP 153
EK +RPTAFKPVLP+ SG+ + S+S +
Sbjct: 139 EKILIRPTAFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSSA 198
Query: 154 PDKPKE-QELKPGLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVG---PTSRFG-- 207
DKP G SG LSDSGRNS+SSLPT+ST + +P + G P+ G
Sbjct: 199 ADKPLAFSGWASGCPSGTLSDSGRNSLSSLPTYSTGGA---EPTTSSPGGHLPSHGSGRG 255
Query: 208 ---GSAHNITQGIVLQDSNMMSLKALSFSDGGSKLG------------HSNKADKGPSCV 252
G A + G DS S + S GG G S+ ++ P
Sbjct: 256 ALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPP 315
Query: 253 RSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPK 312
P S + LE KL +RE LQ+L+ S +E E AYEER R + E E
Sbjct: 316 PPPPSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALR-- 373
Query: 313 GGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTS 372
+Q++QRAQQ+L LQV QLQQEKRQL+ + L++E++ LE + + ERE+
Sbjct: 374 --EDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRE 431
Query: 373 FGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELR 432
GP LEET+WEVCQKSGEISLLKQQLKESQ E+ K SE++ L+ L++ R L E R
Sbjct: 432 LGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGR 491
Query: 433 TQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPT 492
+ L+ A R + LELE C ELQR + EAE LREK L+ E LR P
Sbjct: 492 ARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFL 551
Query: 493 FPEDVPA------------LQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVI 540
E A L+ ++ERLR EL+ ER+ ++ F+ ERL W+ EKE+VI
Sbjct: 552 LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVI 611
Query: 541 QYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDL--EGADIPYEDIIATEI 596
+YQKQLQ +Y+ MY+RN++LE+ LQQL+ A E ++ L + I E+I ATEI
Sbjct: 612 RYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAPCICLEEITATEI 669
>gi|7662176 ProSAPiP1 protein [Homo sapiens]
Length = 673
Score = 302 bits (773), Expect = 7e-82
Identities = 217/582 (37%), Positives = 310/582 (53%), Gaps = 61/582 (10%)
Query: 50 SGHGKSSSKMGK--SEDFFY---IKVSQKARGSHHPDYTALSSGDLGGQA---GVDF--- 98
SG G S + G+ SED + ++ + RGS H D G GG + G D
Sbjct: 74 SGSGASRERPGRYPSEDKGLANSLYLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPP 133
Query: 99 ---DPSTPPKLMPFSNQLEMGSEKGAVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPD 155
+PS PPKL+ S +L+ SE VRP+AFKPV+P++ HS Q + P
Sbjct: 134 QYREPSHPPKLLATSGKLDQCSEP-LVRPSAFKPVVPKN---FHSMQNLCPPQTNGTPEG 189
Query: 156 KPKEQELKPGL-----------CSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPTS 204
+ LK GL LSDSGRNS++SLPT+S+S S L PL +
Sbjct: 190 RQGPGGLKGGLDKSRTMTPAGGSGSGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHIN 249
Query: 205 RFGGSAHNITQG-----------IVLQDSNMMSLKALSFSDGGSKLGHSNKADKG----P 249
R G +++ G + DS S K+ S S G + GH + G P
Sbjct: 250 RIGTASYGSGSGGSSGGGSGYQDLGTSDSGRASSKSGSSSSMG-RPGHLGSGEGGGGGLP 308
Query: 250 SCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGP 309
SP S IQELE++L E+E + L+RS E+ E A + EER + EL
Sbjct: 309 FAACSPPSPSAL-IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAEL 367
Query: 310 EPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYERE 369
KL+Q ++++QRAQQ L LQVL+LQQ+K+QL++E LM++++ LE K+ + ++E
Sbjct: 368 RQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKE 427
Query: 370 KTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGL 429
+ F P +EET+WEVCQK+GEISLLKQQLK+SQ +V+ K SEI+GL++QL++ R L
Sbjct: 428 QADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREK 487
Query: 430 ELRTQDLEGALRTKGLELEVCENELQRKKNEAELL-------REKVNLLEQELQELRAQA 482
E + L + +K LE+ E EL + L ++ + E + ++R QA
Sbjct: 488 EEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQA 547
Query: 483 ALARDMGPPTFPEDVP--------ALQRELERLRAELREERQGHDQMSSGFQHERLVWKE 534
+A + + AL+RE+ RL+AEL ER+ ++ + F ER VW E
Sbjct: 548 GVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLE 607
Query: 535 EKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEP 576
EKEKVI+YQKQLQ SYV MYQRNQ+LE+ L++ A P
Sbjct: 608 EKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTP 649
>gi|62177129 Nedd4 binding protein 3 [Homo sapiens]
Length = 544
Score = 152 bits (383), Expect = 1e-36
Identities = 168/607 (27%), Positives = 258/607 (42%), Gaps = 112/607 (18%)
Query: 1 MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDS--GHGKSSSK 58
MGSV SL+ F + RA+ R S R DGLLR G Q + K
Sbjct: 12 MGSVGSLLERQDFSPEELRAALAGSRGS-------RQPDGLLRKGLGQREFLSYLHLPKK 64
Query: 59 MGKSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSE 118
KS K +++A + DY L + +AG DF ++ P+ F +
Sbjct: 65 DSKST-----KNTKRAPRNEPADYATLYYRE-HSRAG-DFSKTSLPERGRF--------D 109
Query: 119 KGAVRPTAFKPVLPRSGAILHSSPESASHQ---------------LHPAPPDKPKEQELK 163
K +RP+ FKP L S ASH+ HP P+ + +
Sbjct: 110 KCRIRPSVFKPTAGNGKGFL-SMQSLASHKGQKLWRSNGSLHTLACHPPLSPGPRASQAR 168
Query: 164 PGLCSG-ALSDSGRNSMSSLPTHSTSSSYQLDPLVTP------VGPTSRFGGSAHNITQG 216
L +L + G SL S+ S+ P P +G + GGS +QG
Sbjct: 169 AQLLHALSLDEGGPEPEPSLSDSSSGGSFGRSPGTGPSPFSSSLGHLNHLGGSLDRASQG 228
Query: 217 IVLQDSNMMSLKALSFSDGGSKLGHSNKADKGP----SCVRSPISTDECSIQELEQKLLE 272
+ GP SC+ P E S E+
Sbjct: 229 ---------------------------PKEAGPPAVLSCLPEPPPPYEFSCSSAEEMGAV 261
Query: 273 REGALQKLQRSFEEKELASSLAY--EERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQV 330
++L+R +++ ++ EER R EL+ + +L + +QK++R+++
Sbjct: 262 LPETCEELKRGLGDEDGSNPFTQVLEERQRLWLAELKRLYVE---RLHEVTQKAERSERN 318
Query: 331 LHLQVLQLQQEKRQLRQELESLMKEQDLL-ETKLRSYEREKTSFGPALEETQWEVCQKSG 389
L LQ+ QQE+R+LR+EL + +Q L E + E EE +WEVCQK+
Sbjct: 319 LQLQLFMAQQEQRRLRKELRA---QQGLAPEPRAPGTLPEADPSARPEEEARWEVCQKTA 375
Query: 390 EISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEV 449
EISLLKQQL+E+Q E+ K +EI LK QL+ +R + + + L A+R+
Sbjct: 376 EISLLKQQLREAQAELAQKLAEIFSLKTQLRGSRAQAQAQDAELVRLREAVRSL------ 429
Query: 450 CENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRA 509
+ Q + EA E + + L A + ARD E+LRA
Sbjct: 430 ---QEQAPREEAPGSCETDDCKSRGLLG-EAGGSEARDSA---------------EQLRA 470
Query: 510 ELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLAR 569
EL +ER + + F+ ER W+EEKE+V++YQ+++Q Y+ MY+RNQ LE+ L+ L
Sbjct: 471 ELLQERLRGQEQALRFEQERRTWQEEKERVLRYQREIQGGYMDMYRRNQALEQELRALRE 530
Query: 570 GDSAGEP 576
+ P
Sbjct: 531 PPTPWSP 537
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 77.0 bits (188), Expect = 4e-14
Identities = 81/318 (25%), Positives = 140/318 (44%), Gaps = 35/318 (11%)
Query: 271 LEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQV 330
+E E L + QR+ E + LA A E+ R+ + + + + K+ Q+ Q
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 331 LHLQVLQLQQEKRQLRQELESLMKEQDL-LETKLRSYEREKTSFGPALEETQWEVCQKSG 389
+ QQ+KR +++EL+ L + + ++ K R E A E ++ +
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE--------AAERSRLRI---EE 1452
Query: 390 EISLLKQQLKESQTEVNAKASEILGLKAQLKDT-----RGKLEGLELRTQDLEGALRTKG 444
EI +++ QL+ ++ + E+ L+A+ ++ + + E LR Q + + R +
Sbjct: 1453 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512
Query: 445 LELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQREL 504
E+E+ R K EAE REK L Q L+ELR QA A + Q E+
Sbjct: 1513 AEVELA----SRVKAEAEAAREKQRAL-QALEELRLQAEEA----------ERRLRQAEV 1557
Query: 505 ERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKAL 564
ER R + Q +R + EK Q ++ LQ+ +VA+ Q + E+
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASF---AEKTAQLERSLQEEHVAVAQLREEAERRA 1614
Query: 565 QQLARGDSAGEPLEVDLE 582
QQ A + A E E +LE
Sbjct: 1615 QQQAEAERAREEAERELE 1632
Score = 62.8 bits (151), Expect = 9e-10
Identities = 70/314 (22%), Positives = 131/314 (41%), Gaps = 19/314 (6%)
Query: 268 QKLLEREGALQKLQRSFEEKELASSLAYEERPRR--CRDELEGPEPKGGNKLKQASQKSQ 325
Q+ L+ E +K+++ EE S A E R ++L LK+ Q Q
Sbjct: 2263 QRFLQEEA--EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320
Query: 326 RAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVC 385
A + L + LQQ+K +++ L ++++ + +L E F LE +
Sbjct: 2321 EATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQL 2376
Query: 386 QKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGL 445
+ S E LK ++ E + + Q ++ KL EL TQ+ K
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-------KVT 2429
Query: 446 ELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELE 505
++ E + Q+ ++AE LRE + LE+E ++L+ +A L + L +E +
Sbjct: 2430 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2489
Query: 506 RLRAELREERQGHDQMSSGFQHERL----VWKEEKEKVIQYQKQLQQSYVAMYQRNQRLE 561
L+ E+ Q + E+ ++++E K Q +++ Q+ M Q QRL
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 562 KALQQLARGDSAGE 575
++++ R E
Sbjct: 2550 ASMEEARRRQHEAE 2563
Score = 59.3 bits (142), Expect = 1e-08
Identities = 82/342 (23%), Positives = 152/342 (44%), Gaps = 46/342 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
+ +++ L E A ++ + + EE E A E RR R+ E + ++A+QK
Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLK--AKVEEARRLRERAEQESARQLQLAQEAAQK 2045
Query: 324 SQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWE 383
+A++ H +QQ++++L+Q L+ +EQ +L+ +LR E + A EE +
Sbjct: 2046 RLQAEEKAH--AFAVQQKEQELQQTLQ---QEQSVLD-QLRG---EAEAARRAAEEAEEA 2096
Query: 384 VCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKL-----EGLELRTQDLEG 438
Q E + ++Q++E++ + A E +AQ + KL + R Q +
Sbjct: 2097 RVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2155
Query: 439 ALRTKGLELEVCENELQRKKNEAE-LLREKV--------------------NLLEQELQE 477
ALR K + + E+++ K AE LR+K NLL++ELQ
Sbjct: 2156 ALRQK----QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2211
Query: 478 LRAQAALARDMGPPTFPE--DVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEE 535
L+A+A A E V EL +L+A + E + + + + +EE
Sbjct: 2212 LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA--LILRDKDNTQRFLQEE 2269
Query: 536 KEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPL 577
EK+ Q ++ + VA + + + A + LA+ + E +
Sbjct: 2270 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311
Score = 57.4 bits (137), Expect = 4e-08
Identities = 82/331 (24%), Positives = 140/331 (42%), Gaps = 22/331 (6%)
Query: 262 SIQELEQKLLE-REGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQA 320
SIQE Q+L + E +Q R E E S L EE R R +LE E + G +
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475
Query: 321 SQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRS-------YEREKTSF 373
RA++ Q Q Q+E +LR++++ + + E +L S REK
Sbjct: 1476 QALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534
Query: 374 GPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRT 433
ALEE + + + E L + +++ ++ A + +A+L+ R +T
Sbjct: 1535 LQALEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE---KT 1589
Query: 434 QDLEGALRTKGLELEVCENELQRK---KNEAELLREKVNLLEQELQELRAQAALARDMGP 490
LE +L+ + + + E +R+ + EAE RE+ E E +L+A AL +
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELERWQLKANEALRLRLQA 1648
Query: 491 PTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSY 550
+ Q E E+ + E E + + +R + ++E EK Q + Q
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 551 VAMYQRNQRLEKALQQLARGDSAGEPLEVDL 581
+A Q RL +Q G+ + LE +L
Sbjct: 1709 LAAEQELIRLRAETEQ---GEQQRQLLEEEL 1736
Score = 54.7 bits (130), Expect = 2e-07
Identities = 61/252 (24%), Positives = 113/252 (44%), Gaps = 23/252 (9%)
Query: 262 SIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQAS 321
++Q LE+ L+ E A ++L+++ E+ +A E R EL+ K Q
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL- 1592
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
+R+ Q H+ V QL++E + Q+ + ++ E +L ++ + + +
Sbjct: 1593 ---ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 382 WEVCQKSGEISLLKQQLKESQTEV--NAKASEILGLKAQLKDTRGKLEGLELRTQDLEGA 439
QKS + ++Q +E++ E KA E + +L + + LE + Q EG
Sbjct: 1650 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE-----QELEKQRQLAEGT 1704
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPA 499
+ + E EL R + E E ++ LLE+EL L+ +AA A +
Sbjct: 1705 AQQR----LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--------TQKRQE 1752
Query: 500 LQRELERLRAEL 511
L+ EL ++RAE+
Sbjct: 1753 LEAELAKVRAEM 1764
Score = 53.5 bits (127), Expect = 5e-07
Identities = 73/310 (23%), Positives = 138/310 (44%), Gaps = 28/310 (9%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
+ELE+ L+ AL +L+ EE SLA E ++ ++E E + G +QA ++
Sbjct: 1629 RELERWQLKANEAL-RLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQ 1686
Query: 324 SQRAQQVLHLQV----------LQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSF 373
+ A+Q L Q L +QE +LR E E +++ LLE +L +RE +
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1746
Query: 374 GPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRT 433
+E + E+ + E+ +L ++ E + + + K +L+ G+ L
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK---SKQRLEAEAGRFRELAEEA 1803
Query: 434 QDLEGALRTKGLELEVCENELQRKKNEAE-LLREKVNLLEQELQELRAQAAL------AR 486
L + ++ E + R++ EAE +L EK+ + E L+ +A + A
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKEAE 1862
Query: 487 DMGPPTFPEDVPALQRELERLRAELR---EERQGHDQMSSGFQHERLVWKEEKEKVIQYQ 543
+ ED +R LE A+ + EER + +S + ER K E ++ +
Sbjct: 1863 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER--QKGLVEDTLRQR 1920
Query: 544 KQLQQSYVAM 553
+Q+++ +A+
Sbjct: 1921 RQVEEEILAL 1930
Score = 51.2 bits (121), Expect = 3e-06
Identities = 73/335 (21%), Positives = 141/335 (42%), Gaps = 34/335 (10%)
Query: 267 EQKLLEREGALQKL--QRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKS 324
EQ + +RE A Q+L QR E LA E+ R R E E E + L++ +
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARL 1739
Query: 325 QRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEV 384
QR + +L+ E ++R E+E L+ + E + RS + A E+
Sbjct: 1740 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799
Query: 385 CQKSGEISLLKQQLK-------ESQTEVNAKASEILGLK-------------AQLKDTRG 424
+++ + L ++ K E A+A +L K A++
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859
Query: 425 KLEGLELRTQDLEGALRTKGLELEVCENELQ--------RKKNEAELLREKVNLLEQELQ 476
+ E LR + A + + LE + +++ RK +++EL R+K L+E L+
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-GLVEDTLR 1918
Query: 477 ELRA--QAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKE 534
+ R + LA L+ EL R+R+ + + +Q +R + E
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978
Query: 535 EKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLAR 569
E+ + + ++++Q+S A + ++ + AL+++ R
Sbjct: 1979 EERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Score = 50.1 bits (118), Expect = 6e-06
Identities = 63/226 (27%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYE--ERPRRCRDELEGPEPKGGNKLKQAS 321
+E+ +KL E A Q+ + E+ + ER R ELE + K + K
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2470
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
KS+ Q V Q QL QE + L+Q S + E+D L + R E+EK ++
Sbjct: 2471 LKSEEMQTV---QQEQLLQETQALQQ---SFLSEKDSLLQRERFIEQEKAKLEQLFQD-- 2522
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALR 441
E++ +Q +E Q + E L A +++ R R + E +R
Sbjct: 2523 --------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR-------RQHEAEEGVR 2567
Query: 442 TKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQ--AALA 485
K EL+ E Q+++ + ELL E+ L ++LQ L Q AALA
Sbjct: 2568 RKQEELQQLE---QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2610
Score = 44.3 bits (103), Expect = 3e-04
Identities = 72/340 (21%), Positives = 138/340 (40%), Gaps = 41/340 (12%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLA---------YEERPRRCRDELEGPEPKGG 314
Q + ++L + + L++++R E+ E A YE + + +LE P
Sbjct: 1242 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPA 1300
Query: 315 NKLKQASQKSQRAQQVLHL-----QVLQLQQEKRQLRQELESLMKEQDLLETKLRSYERE 369
K K S Q+ + L ++ L + + E M+E++ L + R+ ERE
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1360
Query: 370 KTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKAS-EILGLKAQLKDTRGKLEG 428
+ + A E Q +QL E+ + A+A E L+ ++++ + E
Sbjct: 1361 RLAEVEAALEKQ--------------RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406
Query: 429 LELRTQDLEGALRTKGLEL-EVCENELQRKKNEAELLREKVNLLEQELQELRAQA-ALAR 486
+ Q + +++ + +L + E E+Q K +AE +E+E++ +R Q A R
Sbjct: 1407 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1466
Query: 487 DMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQL 546
G + EL+ LRA E Q + R ++E ++ Q + +L
Sbjct: 1467 QRG---------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 547 QQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADI 586
A + + ++ALQ L E E L A++
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1557
Score = 37.4 bits (85), Expect = 0.039
Identities = 63/282 (22%), Positives = 113/282 (40%), Gaps = 20/282 (7%)
Query: 324 SQRAQQVLHLQVLQLQQEKRQLR--QELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
S QQ+L Q+E R R EL+ + + + ET+ R PA E Q
Sbjct: 962 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 1021
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGL----------KAQLKDTRGKLEGLEL 431
Q+ + + + L + ++A+A ++L L +++L+ T GKLE +
Sbjct: 1022 RIAEQQKAQAEV--EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1079
Query: 432 RTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPP 491
+ L+T L + + + + E L+E + L EL A A + +
Sbjct: 1080 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE-AQAVPATLPELEATKASLKKLRA- 1137
Query: 492 TFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYV 551
A Q + LR ELR ++ +++ + + +E+V Q ++ Q
Sbjct: 1138 ----QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1193
Query: 552 AMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIA 593
R + LE+ +QL + +PL L+ A E I A
Sbjct: 1194 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1235
Score = 34.3 bits (77), Expect = 0.33
Identities = 47/219 (21%), Positives = 91/219 (41%), Gaps = 25/219 (11%)
Query: 263 IQELEQKLLEREGALQKLQRSF--EEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQA 320
+Q ++Q+ L +E Q LQ+SF E+ L + E+ + ++L E +L++
Sbjct: 2476 MQTVQQEQLLQE--TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2533
Query: 321 SQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEET 380
Q+ Q+ Q++QE+++L +E + Q E +R + E +
Sbjct: 2534 QQRQQQ----------QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2583
Query: 381 QWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLK-AQLKDTRGKLEGLELRTQDLEGA 439
+ + +++ + Q L+E A + E+ + A K + L+ + E
Sbjct: 2584 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2643
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
GL R+K A+ L+E L +ELQ L
Sbjct: 2644 HSFDGL----------RRKVSAQRLQEAGILSAEELQRL 2672
Score = 30.0 bits (66), Expect = 6.3
Identities = 39/157 (24%), Positives = 65/157 (41%), Gaps = 7/157 (4%)
Query: 359 LETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQ 418
LE +++ R+ G E + ++ G S QQL +S + + S ++
Sbjct: 929 LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISE 988
Query: 419 LKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
LKD R +LE E RT K E + +++K +AE V L + + L
Sbjct: 989 LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE-----VEGLGKGVARL 1043
Query: 479 RAQAALARDMGPPTFPEDVPALQRELERLRAELREER 515
A+A + P+ P L+ ELE +L + R
Sbjct: 1044 SAEAEKVLALPEPS--PAAPTLRSELELTLGKLEQVR 1078
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 77.0 bits (188), Expect = 4e-14
Identities = 81/318 (25%), Positives = 140/318 (44%), Gaps = 35/318 (11%)
Query: 271 LEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQV 330
+E E L + QR+ E + LA A E+ R+ + + + + K+ Q+ Q
Sbjct: 1348 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407
Query: 331 LHLQVLQLQQEKRQLRQELESLMKEQDL-LETKLRSYEREKTSFGPALEETQWEVCQKSG 389
+ QQ+KR +++EL+ L + + ++ K R E A E ++ +
Sbjct: 1408 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE--------AAERSRLRI---EE 1456
Query: 390 EISLLKQQLKESQTEVNAKASEILGLKAQLKDT-----RGKLEGLELRTQDLEGALRTKG 444
EI +++ QL+ ++ + E+ L+A+ ++ + + E LR Q + + R +
Sbjct: 1457 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1516
Query: 445 LELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQREL 504
E+E+ R K EAE REK L Q L+ELR QA A + Q E+
Sbjct: 1517 AEVELA----SRVKAEAEAAREKQRAL-QALEELRLQAEEA----------ERRLRQAEV 1561
Query: 505 ERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKAL 564
ER R + Q +R + EK Q ++ LQ+ +VA+ Q + E+
Sbjct: 1562 ERARQVQVALETAQRSAEAELQSKRASF---AEKTAQLERSLQEEHVAVAQLREEAERRA 1618
Query: 565 QQLARGDSAGEPLEVDLE 582
QQ A + A E E +LE
Sbjct: 1619 QQQAEAERAREEAERELE 1636
Score = 62.8 bits (151), Expect = 9e-10
Identities = 70/314 (22%), Positives = 131/314 (41%), Gaps = 19/314 (6%)
Query: 268 QKLLEREGALQKLQRSFEEKELASSLAYEERPRR--CRDELEGPEPKGGNKLKQASQKSQ 325
Q+ L+ E +K+++ EE S A E R ++L LK+ Q Q
Sbjct: 2267 QRFLQEEA--EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2324
Query: 326 RAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVC 385
A + L + LQQ+K +++ L ++++ + +L E F LE +
Sbjct: 2325 EATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQL 2380
Query: 386 QKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGL 445
+ S E LK ++ E + + Q ++ KL EL TQ+ K
Sbjct: 2381 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-------KVT 2433
Query: 446 ELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELE 505
++ E + Q+ ++AE LRE + LE+E ++L+ +A L + L +E +
Sbjct: 2434 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2493
Query: 506 RLRAELREERQGHDQMSSGFQHERL----VWKEEKEKVIQYQKQLQQSYVAMYQRNQRLE 561
L+ E+ Q + E+ ++++E K Q +++ Q+ M Q QRL
Sbjct: 2494 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2553
Query: 562 KALQQLARGDSAGE 575
++++ R E
Sbjct: 2554 ASMEEARRRQHEAE 2567
Score = 59.3 bits (142), Expect = 1e-08
Identities = 82/342 (23%), Positives = 152/342 (44%), Gaps = 46/342 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
+ +++ L E A ++ + + EE E A E RR R+ E + ++A+QK
Sbjct: 1992 ERVQKSLAAEEEAARQRKAALEEVERLK--AKVEEARRLRERAEQESARQLQLAQEAAQK 2049
Query: 324 SQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWE 383
+A++ H +QQ++++L+Q L+ +EQ +L+ +LR E + A EE +
Sbjct: 2050 RLQAEEKAH--AFAVQQKEQELQQTLQ---QEQSVLD-QLRG---EAEAARRAAEEAEEA 2100
Query: 384 VCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKL-----EGLELRTQDLEG 438
Q E + ++Q++E++ + A E +AQ + KL + R Q +
Sbjct: 2101 RVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2159
Query: 439 ALRTKGLELEVCENELQRKKNEAE-LLREKV--------------------NLLEQELQE 477
ALR K + + E+++ K AE LR+K NLL++ELQ
Sbjct: 2160 ALRQK----QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2215
Query: 478 LRAQAALARDMGPPTFPE--DVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEE 535
L+A+A A E V EL +L+A + E + + + + +EE
Sbjct: 2216 LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA--LILRDKDNTQRFLQEE 2273
Query: 536 KEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPL 577
EK+ Q ++ + VA + + + A + LA+ + E +
Sbjct: 2274 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2315
Score = 57.4 bits (137), Expect = 4e-08
Identities = 82/331 (24%), Positives = 140/331 (42%), Gaps = 22/331 (6%)
Query: 262 SIQELEQKLLE-REGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQA 320
SIQE Q+L + E +Q R E E S L EE R R +LE E + G +
Sbjct: 1421 SIQEELQQLRQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1479
Query: 321 SQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRS-------YEREKTSF 373
RA++ Q Q Q+E +LR++++ + + E +L S REK
Sbjct: 1480 QALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1538
Query: 374 GPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRT 433
ALEE + + + E L + +++ ++ A + +A+L+ R +T
Sbjct: 1539 LQALEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE---KT 1593
Query: 434 QDLEGALRTKGLELEVCENELQRK---KNEAELLREKVNLLEQELQELRAQAALARDMGP 490
LE +L+ + + + E +R+ + EAE RE+ E E +L+A AL +
Sbjct: 1594 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELERWQLKANEALRLRLQA 1652
Query: 491 PTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSY 550
+ Q E E+ + E E + + +R + ++E EK Q + Q
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1712
Query: 551 VAMYQRNQRLEKALQQLARGDSAGEPLEVDL 581
+A Q RL +Q G+ + LE +L
Sbjct: 1713 LAAEQELIRLRAETEQ---GEQQRQLLEEEL 1740
Score = 54.7 bits (130), Expect = 2e-07
Identities = 61/252 (24%), Positives = 113/252 (44%), Gaps = 23/252 (9%)
Query: 262 SIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQAS 321
++Q LE+ L+ E A ++L+++ E+ +A E R EL+ K Q
Sbjct: 1538 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL- 1596
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
+R+ Q H+ V QL++E + Q+ + ++ E +L ++ + + +
Sbjct: 1597 ---ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1653
Query: 382 WEVCQKSGEISLLKQQLKESQTEV--NAKASEILGLKAQLKDTRGKLEGLELRTQDLEGA 439
QKS + ++Q +E++ E KA E + +L + + LE + Q EG
Sbjct: 1654 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE-----QELEKQRQLAEGT 1708
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPA 499
+ + E EL R + E E ++ LLE+EL L+ +AA A +
Sbjct: 1709 AQQR----LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--------TQKRQE 1756
Query: 500 LQRELERLRAEL 511
L+ EL ++RAE+
Sbjct: 1757 LEAELAKVRAEM 1768
Score = 53.5 bits (127), Expect = 5e-07
Identities = 73/310 (23%), Positives = 138/310 (44%), Gaps = 28/310 (9%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
+ELE+ L+ AL +L+ EE SLA E ++ ++E E + G +QA ++
Sbjct: 1633 RELERWQLKANEAL-RLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQ 1690
Query: 324 SQRAQQVLHLQV----------LQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSF 373
+ A+Q L Q L +QE +LR E E +++ LLE +L +RE +
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1750
Query: 374 GPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRT 433
+E + E+ + E+ +L ++ E + + + K +L+ G+ L
Sbjct: 1751 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK---SKQRLEAEAGRFRELAEEA 1807
Query: 434 QDLEGALRTKGLELEVCENELQRKKNEAE-LLREKVNLLEQELQELRAQAAL------AR 486
L + ++ E + R++ EAE +L EK+ + E L+ +A + A
Sbjct: 1808 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKEAE 1866
Query: 487 DMGPPTFPEDVPALQRELERLRAELR---EERQGHDQMSSGFQHERLVWKEEKEKVIQYQ 543
+ ED +R LE A+ + EER + +S + ER K E ++ +
Sbjct: 1867 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER--QKGLVEDTLRQR 1924
Query: 544 KQLQQSYVAM 553
+Q+++ +A+
Sbjct: 1925 RQVEEEILAL 1934
Score = 51.2 bits (121), Expect = 3e-06
Identities = 73/335 (21%), Positives = 141/335 (42%), Gaps = 34/335 (10%)
Query: 267 EQKLLEREGALQKL--QRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKS 324
EQ + +RE A Q+L QR E LA E+ R R E E E + L++ +
Sbjct: 1685 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARL 1743
Query: 325 QRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEV 384
QR + +L+ E ++R E+E L+ + E + RS + A E+
Sbjct: 1744 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1803
Query: 385 CQKSGEISLLKQQLK-------ESQTEVNAKASEILGLK-------------AQLKDTRG 424
+++ + L ++ K E A+A +L K A++
Sbjct: 1804 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1863
Query: 425 KLEGLELRTQDLEGALRTKGLELEVCENELQ--------RKKNEAELLREKVNLLEQELQ 476
+ E LR + A + + LE + +++ RK +++EL R+K L+E L+
Sbjct: 1864 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-GLVEDTLR 1922
Query: 477 ELRA--QAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKE 534
+ R + LA L+ EL R+R+ + + +Q +R + E
Sbjct: 1923 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1982
Query: 535 EKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLAR 569
E+ + + ++++Q+S A + ++ + AL+++ R
Sbjct: 1983 EERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2017
Score = 50.1 bits (118), Expect = 6e-06
Identities = 63/226 (27%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYE--ERPRRCRDELEGPEPKGGNKLKQAS 321
+E+ +KL E A Q+ + E+ + ER R ELE + K + K
Sbjct: 2415 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2474
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
KS+ Q V Q QL QE + L+Q S + E+D L + R E+EK ++
Sbjct: 2475 LKSEEMQTV---QQEQLLQETQALQQ---SFLSEKDSLLQRERFIEQEKAKLEQLFQD-- 2526
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALR 441
E++ +Q +E Q + E L A +++ R R + E +R
Sbjct: 2527 --------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR-------RQHEAEEGVR 2571
Query: 442 TKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQ--AALA 485
K EL+ E Q+++ + ELL E+ L ++LQ L Q AALA
Sbjct: 2572 RKQEELQQLE---QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2614
Score = 44.3 bits (103), Expect = 3e-04
Identities = 72/340 (21%), Positives = 138/340 (40%), Gaps = 41/340 (12%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLA---------YEERPRRCRDELEGPEPKGG 314
Q + ++L + + L++++R E+ E A YE + + +LE P
Sbjct: 1246 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPA 1304
Query: 315 NKLKQASQKSQRAQQVLHL-----QVLQLQQEKRQLRQELESLMKEQDLLETKLRSYERE 369
K K S Q+ + L ++ L + + E M+E++ L + R+ ERE
Sbjct: 1305 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1364
Query: 370 KTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKAS-EILGLKAQLKDTRGKLEG 428
+ + A E Q +QL E+ + A+A E L+ ++++ + E
Sbjct: 1365 RLAEVEAALEKQ--------------RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1410
Query: 429 LELRTQDLEGALRTKGLEL-EVCENELQRKKNEAELLREKVNLLEQELQELRAQA-ALAR 486
+ Q + +++ + +L + E E+Q K +AE +E+E++ +R Q A R
Sbjct: 1411 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1470
Query: 487 DMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQL 546
G + EL+ LRA E Q + R ++E ++ Q + +L
Sbjct: 1471 QRG---------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1521
Query: 547 QQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADI 586
A + + ++ALQ L E E L A++
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1561
Score = 37.4 bits (85), Expect = 0.039
Identities = 63/282 (22%), Positives = 113/282 (40%), Gaps = 20/282 (7%)
Query: 324 SQRAQQVLHLQVLQLQQEKRQLR--QELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
S QQ+L Q+E R R EL+ + + + ET+ R PA E Q
Sbjct: 966 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 1025
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGL----------KAQLKDTRGKLEGLEL 431
Q+ + + + L + ++A+A ++L L +++L+ T GKLE +
Sbjct: 1026 RIAEQQKAQAEV--EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1083
Query: 432 RTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPP 491
+ L+T L + + + + E L+E + L EL A A + +
Sbjct: 1084 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE-AQAVPATLPELEATKASLKKLRA- 1141
Query: 492 TFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYV 551
A Q + LR ELR ++ +++ + + +E+V Q ++ Q
Sbjct: 1142 ----QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1197
Query: 552 AMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIA 593
R + LE+ +QL + +PL L+ A E I A
Sbjct: 1198 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1239
Score = 34.3 bits (77), Expect = 0.33
Identities = 47/219 (21%), Positives = 91/219 (41%), Gaps = 25/219 (11%)
Query: 263 IQELEQKLLEREGALQKLQRSF--EEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQA 320
+Q ++Q+ L +E Q LQ+SF E+ L + E+ + ++L E +L++
Sbjct: 2480 MQTVQQEQLLQE--TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2537
Query: 321 SQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEET 380
Q+ Q+ Q++QE+++L +E + Q E +R + E +
Sbjct: 2538 QQRQQQ----------QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2587
Query: 381 QWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLK-AQLKDTRGKLEGLELRTQDLEGA 439
+ + +++ + Q L+E A + E+ + A K + L+ + E
Sbjct: 2588 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2647
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
GL R+K A+ L+E L +ELQ L
Sbjct: 2648 HSFDGL----------RRKVSAQRLQEAGILSAEELQRL 2676
Score = 30.0 bits (66), Expect = 6.3
Identities = 39/157 (24%), Positives = 65/157 (41%), Gaps = 7/157 (4%)
Query: 359 LETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQ 418
LE +++ R+ G E + ++ G S QQL +S + + S ++
Sbjct: 933 LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISE 992
Query: 419 LKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
LKD R +LE E RT K E + +++K +AE V L + + L
Sbjct: 993 LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE-----VEGLGKGVARL 1047
Query: 479 RAQAALARDMGPPTFPEDVPALQRELERLRAELREER 515
A+A + P+ P L+ ELE +L + R
Sbjct: 1048 SAEAEKVLALPEPS--PAAPTLRSELELTLGKLEQVR 1082
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 77.0 bits (188), Expect = 4e-14
Identities = 81/318 (25%), Positives = 140/318 (44%), Gaps = 35/318 (11%)
Query: 271 LEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQV 330
+E E L + QR+ E + LA A E+ R+ + + + + K+ Q+ Q
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 331 LHLQVLQLQQEKRQLRQELESLMKEQDL-LETKLRSYEREKTSFGPALEETQWEVCQKSG 389
+ QQ+KR +++EL+ L + + ++ K R E A E ++ +
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE--------AAERSRLRI---EE 1452
Query: 390 EISLLKQQLKESQTEVNAKASEILGLKAQLKDT-----RGKLEGLELRTQDLEGALRTKG 444
EI +++ QL+ ++ + E+ L+A+ ++ + + E LR Q + + R +
Sbjct: 1453 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512
Query: 445 LELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQREL 504
E+E+ R K EAE REK L Q L+ELR QA A + Q E+
Sbjct: 1513 AEVELA----SRVKAEAEAAREKQRAL-QALEELRLQAEEA----------ERRLRQAEV 1557
Query: 505 ERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKAL 564
ER R + Q +R + EK Q ++ LQ+ +VA+ Q + E+
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASF---AEKTAQLERSLQEEHVAVAQLREEAERRA 1614
Query: 565 QQLARGDSAGEPLEVDLE 582
QQ A + A E E +LE
Sbjct: 1615 QQQAEAERAREEAERELE 1632
Score = 62.8 bits (151), Expect = 9e-10
Identities = 70/314 (22%), Positives = 131/314 (41%), Gaps = 19/314 (6%)
Query: 268 QKLLEREGALQKLQRSFEEKELASSLAYEERPRR--CRDELEGPEPKGGNKLKQASQKSQ 325
Q+ L+ E +K+++ EE S A E R ++L LK+ Q Q
Sbjct: 2263 QRFLQEEA--EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320
Query: 326 RAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVC 385
A + L + LQQ+K +++ L ++++ + +L E F LE +
Sbjct: 2321 EATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQL 2376
Query: 386 QKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGL 445
+ S E LK ++ E + + Q ++ KL EL TQ+ K
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-------KVT 2429
Query: 446 ELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELE 505
++ E + Q+ ++AE LRE + LE+E ++L+ +A L + L +E +
Sbjct: 2430 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2489
Query: 506 RLRAELREERQGHDQMSSGFQHERL----VWKEEKEKVIQYQKQLQQSYVAMYQRNQRLE 561
L+ E+ Q + E+ ++++E K Q +++ Q+ M Q QRL
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 562 KALQQLARGDSAGE 575
++++ R E
Sbjct: 2550 ASMEEARRRQHEAE 2563
Score = 59.3 bits (142), Expect = 1e-08
Identities = 82/342 (23%), Positives = 152/342 (44%), Gaps = 46/342 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
+ +++ L E A ++ + + EE E A E RR R+ E + ++A+QK
Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLK--AKVEEARRLRERAEQESARQLQLAQEAAQK 2045
Query: 324 SQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWE 383
+A++ H +QQ++++L+Q L+ +EQ +L+ +LR E + A EE +
Sbjct: 2046 RLQAEEKAH--AFAVQQKEQELQQTLQ---QEQSVLD-QLRG---EAEAARRAAEEAEEA 2096
Query: 384 VCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKL-----EGLELRTQDLEG 438
Q E + ++Q++E++ + A E +AQ + KL + R Q +
Sbjct: 2097 RVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2155
Query: 439 ALRTKGLELEVCENELQRKKNEAE-LLREKV--------------------NLLEQELQE 477
ALR K + + E+++ K AE LR+K NLL++ELQ
Sbjct: 2156 ALRQK----QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2211
Query: 478 LRAQAALARDMGPPTFPE--DVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEE 535
L+A+A A E V EL +L+A + E + + + + +EE
Sbjct: 2212 LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA--LILRDKDNTQRFLQEE 2269
Query: 536 KEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPL 577
EK+ Q ++ + VA + + + A + LA+ + E +
Sbjct: 2270 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311
Score = 57.4 bits (137), Expect = 4e-08
Identities = 82/331 (24%), Positives = 140/331 (42%), Gaps = 22/331 (6%)
Query: 262 SIQELEQKLLE-REGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQA 320
SIQE Q+L + E +Q R E E S L EE R R +LE E + G +
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475
Query: 321 SQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRS-------YEREKTSF 373
RA++ Q Q Q+E +LR++++ + + E +L S REK
Sbjct: 1476 QALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534
Query: 374 GPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRT 433
ALEE + + + E L + +++ ++ A + +A+L+ R +T
Sbjct: 1535 LQALEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE---KT 1589
Query: 434 QDLEGALRTKGLELEVCENELQRK---KNEAELLREKVNLLEQELQELRAQAALARDMGP 490
LE +L+ + + + E +R+ + EAE RE+ E E +L+A AL +
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELERWQLKANEALRLRLQA 1648
Query: 491 PTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSY 550
+ Q E E+ + E E + + +R + ++E EK Q + Q
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 551 VAMYQRNQRLEKALQQLARGDSAGEPLEVDL 581
+A Q RL +Q G+ + LE +L
Sbjct: 1709 LAAEQELIRLRAETEQ---GEQQRQLLEEEL 1736
Score = 54.7 bits (130), Expect = 2e-07
Identities = 61/252 (24%), Positives = 113/252 (44%), Gaps = 23/252 (9%)
Query: 262 SIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQAS 321
++Q LE+ L+ E A ++L+++ E+ +A E R EL+ K Q
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL- 1592
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
+R+ Q H+ V QL++E + Q+ + ++ E +L ++ + + +
Sbjct: 1593 ---ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 382 WEVCQKSGEISLLKQQLKESQTEV--NAKASEILGLKAQLKDTRGKLEGLELRTQDLEGA 439
QKS + ++Q +E++ E KA E + +L + + LE + Q EG
Sbjct: 1650 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE-----QELEKQRQLAEGT 1704
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPA 499
+ + E EL R + E E ++ LLE+EL L+ +AA A +
Sbjct: 1705 AQQR----LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--------TQKRQE 1752
Query: 500 LQRELERLRAEL 511
L+ EL ++RAE+
Sbjct: 1753 LEAELAKVRAEM 1764
Score = 53.5 bits (127), Expect = 5e-07
Identities = 73/310 (23%), Positives = 138/310 (44%), Gaps = 28/310 (9%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
+ELE+ L+ AL +L+ EE SLA E ++ ++E E + G +QA ++
Sbjct: 1629 RELERWQLKANEAL-RLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQ 1686
Query: 324 SQRAQQVLHLQV----------LQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSF 373
+ A+Q L Q L +QE +LR E E +++ LLE +L +RE +
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1746
Query: 374 GPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRT 433
+E + E+ + E+ +L ++ E + + + K +L+ G+ L
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK---SKQRLEAEAGRFRELAEEA 1803
Query: 434 QDLEGALRTKGLELEVCENELQRKKNEAE-LLREKVNLLEQELQELRAQAAL------AR 486
L + ++ E + R++ EAE +L EK+ + E L+ +A + A
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKEAE 1862
Query: 487 DMGPPTFPEDVPALQRELERLRAELR---EERQGHDQMSSGFQHERLVWKEEKEKVIQYQ 543
+ ED +R LE A+ + EER + +S + ER K E ++ +
Sbjct: 1863 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER--QKGLVEDTLRQR 1920
Query: 544 KQLQQSYVAM 553
+Q+++ +A+
Sbjct: 1921 RQVEEEILAL 1930
Score = 51.2 bits (121), Expect = 3e-06
Identities = 73/335 (21%), Positives = 141/335 (42%), Gaps = 34/335 (10%)
Query: 267 EQKLLEREGALQKL--QRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKS 324
EQ + +RE A Q+L QR E LA E+ R R E E E + L++ +
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARL 1739
Query: 325 QRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEV 384
QR + +L+ E ++R E+E L+ + E + RS + A E+
Sbjct: 1740 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799
Query: 385 CQKSGEISLLKQQLK-------ESQTEVNAKASEILGLK-------------AQLKDTRG 424
+++ + L ++ K E A+A +L K A++
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859
Query: 425 KLEGLELRTQDLEGALRTKGLELEVCENELQ--------RKKNEAELLREKVNLLEQELQ 476
+ E LR + A + + LE + +++ RK +++EL R+K L+E L+
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-GLVEDTLR 1918
Query: 477 ELRA--QAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKE 534
+ R + LA L+ EL R+R+ + + +Q +R + E
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978
Query: 535 EKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLAR 569
E+ + + ++++Q+S A + ++ + AL+++ R
Sbjct: 1979 EERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Score = 50.1 bits (118), Expect = 6e-06
Identities = 63/226 (27%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYE--ERPRRCRDELEGPEPKGGNKLKQAS 321
+E+ +KL E A Q+ + E+ + ER R ELE + K + K
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2470
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
KS+ Q V Q QL QE + L+Q S + E+D L + R E+EK ++
Sbjct: 2471 LKSEEMQTV---QQEQLLQETQALQQ---SFLSEKDSLLQRERFIEQEKAKLEQLFQD-- 2522
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALR 441
E++ +Q +E Q + E L A +++ R R + E +R
Sbjct: 2523 --------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR-------RQHEAEEGVR 2567
Query: 442 TKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQ--AALA 485
K EL+ E Q+++ + ELL E+ L ++LQ L Q AALA
Sbjct: 2568 RKQEELQQLE---QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2610
Score = 44.3 bits (103), Expect = 3e-04
Identities = 72/340 (21%), Positives = 138/340 (40%), Gaps = 41/340 (12%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLA---------YEERPRRCRDELEGPEPKGG 314
Q + ++L + + L++++R E+ E A YE + + +LE P
Sbjct: 1242 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPA 1300
Query: 315 NKLKQASQKSQRAQQVLHL-----QVLQLQQEKRQLRQELESLMKEQDLLETKLRSYERE 369
K K S Q+ + L ++ L + + E M+E++ L + R+ ERE
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1360
Query: 370 KTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKAS-EILGLKAQLKDTRGKLEG 428
+ + A E Q +QL E+ + A+A E L+ ++++ + E
Sbjct: 1361 RLAEVEAALEKQ--------------RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406
Query: 429 LELRTQDLEGALRTKGLEL-EVCENELQRKKNEAELLREKVNLLEQELQELRAQA-ALAR 486
+ Q + +++ + +L + E E+Q K +AE +E+E++ +R Q A R
Sbjct: 1407 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1466
Query: 487 DMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQL 546
G + EL+ LRA E Q + R ++E ++ Q + +L
Sbjct: 1467 QRG---------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 547 QQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADI 586
A + + ++ALQ L E E L A++
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1557
Score = 37.4 bits (85), Expect = 0.039
Identities = 63/282 (22%), Positives = 113/282 (40%), Gaps = 20/282 (7%)
Query: 324 SQRAQQVLHLQVLQLQQEKRQLR--QELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
S QQ+L Q+E R R EL+ + + + ET+ R PA E Q
Sbjct: 962 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 1021
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGL----------KAQLKDTRGKLEGLEL 431
Q+ + + + L + ++A+A ++L L +++L+ T GKLE +
Sbjct: 1022 RIAEQQKAQAEV--EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1079
Query: 432 RTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPP 491
+ L+T L + + + + E L+E + L EL A A + +
Sbjct: 1080 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE-AQAVPATLPELEATKASLKKLRA- 1137
Query: 492 TFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYV 551
A Q + LR ELR ++ +++ + + +E+V Q ++ Q
Sbjct: 1138 ----QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1193
Query: 552 AMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIA 593
R + LE+ +QL + +PL L+ A E I A
Sbjct: 1194 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1235
Score = 34.3 bits (77), Expect = 0.33
Identities = 47/219 (21%), Positives = 91/219 (41%), Gaps = 25/219 (11%)
Query: 263 IQELEQKLLEREGALQKLQRSF--EEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQA 320
+Q ++Q+ L +E Q LQ+SF E+ L + E+ + ++L E +L++
Sbjct: 2476 MQTVQQEQLLQE--TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2533
Query: 321 SQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEET 380
Q+ Q+ Q++QE+++L +E + Q E +R + E +
Sbjct: 2534 QQRQQQ----------QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2583
Query: 381 QWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLK-AQLKDTRGKLEGLELRTQDLEGA 439
+ + +++ + Q L+E A + E+ + A K + L+ + E
Sbjct: 2584 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2643
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
GL R+K A+ L+E L +ELQ L
Sbjct: 2644 HSFDGL----------RRKVSAQRLQEAGILSAEELQRL 2672
Score = 30.0 bits (66), Expect = 6.3
Identities = 39/157 (24%), Positives = 65/157 (41%), Gaps = 7/157 (4%)
Query: 359 LETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQ 418
LE +++ R+ G E + ++ G S QQL +S + + S ++
Sbjct: 929 LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISE 988
Query: 419 LKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
LKD R +LE E RT K E + +++K +AE V L + + L
Sbjct: 989 LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE-----VEGLGKGVARL 1043
Query: 479 RAQAALARDMGPPTFPEDVPALQRELERLRAELREER 515
A+A + P+ P L+ ELE +L + R
Sbjct: 1044 SAEAEKVLALPEPS--PAAPTLRSELELTLGKLEQVR 1078
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 77.0 bits (188), Expect = 4e-14
Identities = 81/318 (25%), Positives = 140/318 (44%), Gaps = 35/318 (11%)
Query: 271 LEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQV 330
+E E L + QR+ E + LA A E+ R+ + + + + K+ Q+ Q
Sbjct: 1312 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371
Query: 331 LHLQVLQLQQEKRQLRQELESLMKEQDL-LETKLRSYEREKTSFGPALEETQWEVCQKSG 389
+ QQ+KR +++EL+ L + + ++ K R E A E ++ +
Sbjct: 1372 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE--------AAERSRLRI---EE 1420
Query: 390 EISLLKQQLKESQTEVNAKASEILGLKAQLKDT-----RGKLEGLELRTQDLEGALRTKG 444
EI +++ QL+ ++ + E+ L+A+ ++ + + E LR Q + + R +
Sbjct: 1421 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1480
Query: 445 LELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQREL 504
E+E+ R K EAE REK L Q L+ELR QA A + Q E+
Sbjct: 1481 AEVELA----SRVKAEAEAAREKQRAL-QALEELRLQAEEA----------ERRLRQAEV 1525
Query: 505 ERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKAL 564
ER R + Q +R + EK Q ++ LQ+ +VA+ Q + E+
Sbjct: 1526 ERARQVQVALETAQRSAEAELQSKRASF---AEKTAQLERSLQEEHVAVAQLREEAERRA 1582
Query: 565 QQLARGDSAGEPLEVDLE 582
QQ A + A E E +LE
Sbjct: 1583 QQQAEAERAREEAERELE 1600
Score = 62.8 bits (151), Expect = 9e-10
Identities = 70/314 (22%), Positives = 131/314 (41%), Gaps = 19/314 (6%)
Query: 268 QKLLEREGALQKLQRSFEEKELASSLAYEERPRR--CRDELEGPEPKGGNKLKQASQKSQ 325
Q+ L+ E +K+++ EE S A E R ++L LK+ Q Q
Sbjct: 2231 QRFLQEEA--EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2288
Query: 326 RAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVC 385
A + L + LQQ+K +++ L ++++ + +L E F LE +
Sbjct: 2289 EATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQL 2344
Query: 386 QKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGL 445
+ S E LK ++ E + + Q ++ KL EL TQ+ K
Sbjct: 2345 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-------KVT 2397
Query: 446 ELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELE 505
++ E + Q+ ++AE LRE + LE+E ++L+ +A L + L +E +
Sbjct: 2398 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2457
Query: 506 RLRAELREERQGHDQMSSGFQHERL----VWKEEKEKVIQYQKQLQQSYVAMYQRNQRLE 561
L+ E+ Q + E+ ++++E K Q +++ Q+ M Q QRL
Sbjct: 2458 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2517
Query: 562 KALQQLARGDSAGE 575
++++ R E
Sbjct: 2518 ASMEEARRRQHEAE 2531
Score = 59.3 bits (142), Expect = 1e-08
Identities = 82/342 (23%), Positives = 152/342 (44%), Gaps = 46/342 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
+ +++ L E A ++ + + EE E A E RR R+ E + ++A+QK
Sbjct: 1956 ERVQKSLAAEEEAARQRKAALEEVERLK--AKVEEARRLRERAEQESARQLQLAQEAAQK 2013
Query: 324 SQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWE 383
+A++ H +QQ++++L+Q L+ +EQ +L+ +LR E + A EE +
Sbjct: 2014 RLQAEEKAH--AFAVQQKEQELQQTLQ---QEQSVLD-QLRG---EAEAARRAAEEAEEA 2064
Query: 384 VCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKL-----EGLELRTQDLEG 438
Q E + ++Q++E++ + A E +AQ + KL + R Q +
Sbjct: 2065 RVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2123
Query: 439 ALRTKGLELEVCENELQRKKNEAE-LLREKV--------------------NLLEQELQE 477
ALR K + + E+++ K AE LR+K NLL++ELQ
Sbjct: 2124 ALRQK----QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2179
Query: 478 LRAQAALARDMGPPTFPE--DVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEE 535
L+A+A A E V EL +L+A + E + + + + +EE
Sbjct: 2180 LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA--LILRDKDNTQRFLQEE 2237
Query: 536 KEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPL 577
EK+ Q ++ + VA + + + A + LA+ + E +
Sbjct: 2238 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2279
Score = 57.4 bits (137), Expect = 4e-08
Identities = 82/331 (24%), Positives = 140/331 (42%), Gaps = 22/331 (6%)
Query: 262 SIQELEQKLLE-REGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQA 320
SIQE Q+L + E +Q R E E S L EE R R +LE E + G +
Sbjct: 1385 SIQEELQQLRQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1443
Query: 321 SQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRS-------YEREKTSF 373
RA++ Q Q Q+E +LR++++ + + E +L S REK
Sbjct: 1444 QALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1502
Query: 374 GPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRT 433
ALEE + + + E L + +++ ++ A + +A+L+ R +T
Sbjct: 1503 LQALEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE---KT 1557
Query: 434 QDLEGALRTKGLELEVCENELQRK---KNEAELLREKVNLLEQELQELRAQAALARDMGP 490
LE +L+ + + + E +R+ + EAE RE+ E E +L+A AL +
Sbjct: 1558 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELERWQLKANEALRLRLQA 1616
Query: 491 PTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSY 550
+ Q E E+ + E E + + +R + ++E EK Q + Q
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1676
Query: 551 VAMYQRNQRLEKALQQLARGDSAGEPLEVDL 581
+A Q RL +Q G+ + LE +L
Sbjct: 1677 LAAEQELIRLRAETEQ---GEQQRQLLEEEL 1704
Score = 54.7 bits (130), Expect = 2e-07
Identities = 61/252 (24%), Positives = 113/252 (44%), Gaps = 23/252 (9%)
Query: 262 SIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQAS 321
++Q LE+ L+ E A ++L+++ E+ +A E R EL+ K Q
Sbjct: 1502 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL- 1560
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
+R+ Q H+ V QL++E + Q+ + ++ E +L ++ + + +
Sbjct: 1561 ---ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1617
Query: 382 WEVCQKSGEISLLKQQLKESQTEV--NAKASEILGLKAQLKDTRGKLEGLELRTQDLEGA 439
QKS + ++Q +E++ E KA E + +L + + LE + Q EG
Sbjct: 1618 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE-----QELEKQRQLAEGT 1672
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPA 499
+ + E EL R + E E ++ LLE+EL L+ +AA A +
Sbjct: 1673 AQQR----LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--------TQKRQE 1720
Query: 500 LQRELERLRAEL 511
L+ EL ++RAE+
Sbjct: 1721 LEAELAKVRAEM 1732
Score = 53.5 bits (127), Expect = 5e-07
Identities = 73/310 (23%), Positives = 138/310 (44%), Gaps = 28/310 (9%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
+ELE+ L+ AL +L+ EE SLA E ++ ++E E + G +QA ++
Sbjct: 1597 RELERWQLKANEAL-RLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQ 1654
Query: 324 SQRAQQVLHLQV----------LQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSF 373
+ A+Q L Q L +QE +LR E E +++ LLE +L +RE +
Sbjct: 1655 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1714
Query: 374 GPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRT 433
+E + E+ + E+ +L ++ E + + + K +L+ G+ L
Sbjct: 1715 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK---SKQRLEAEAGRFRELAEEA 1771
Query: 434 QDLEGALRTKGLELEVCENELQRKKNEAE-LLREKVNLLEQELQELRAQAAL------AR 486
L + ++ E + R++ EAE +L EK+ + E L+ +A + A
Sbjct: 1772 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKEAE 1830
Query: 487 DMGPPTFPEDVPALQRELERLRAELR---EERQGHDQMSSGFQHERLVWKEEKEKVIQYQ 543
+ ED +R LE A+ + EER + +S + ER K E ++ +
Sbjct: 1831 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER--QKGLVEDTLRQR 1888
Query: 544 KQLQQSYVAM 553
+Q+++ +A+
Sbjct: 1889 RQVEEEILAL 1898
Score = 51.2 bits (121), Expect = 3e-06
Identities = 73/335 (21%), Positives = 141/335 (42%), Gaps = 34/335 (10%)
Query: 267 EQKLLEREGALQKL--QRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKS 324
EQ + +RE A Q+L QR E LA E+ R R E E E + L++ +
Sbjct: 1649 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARL 1707
Query: 325 QRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEV 384
QR + +L+ E ++R E+E L+ + E + RS + A E+
Sbjct: 1708 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1767
Query: 385 CQKSGEISLLKQQLK-------ESQTEVNAKASEILGLK-------------AQLKDTRG 424
+++ + L ++ K E A+A +L K A++
Sbjct: 1768 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1827
Query: 425 KLEGLELRTQDLEGALRTKGLELEVCENELQ--------RKKNEAELLREKVNLLEQELQ 476
+ E LR + A + + LE + +++ RK +++EL R+K L+E L+
Sbjct: 1828 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-GLVEDTLR 1886
Query: 477 ELRA--QAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKE 534
+ R + LA L+ EL R+R+ + + +Q +R + E
Sbjct: 1887 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1946
Query: 535 EKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLAR 569
E+ + + ++++Q+S A + ++ + AL+++ R
Sbjct: 1947 EERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1981
Score = 50.1 bits (118), Expect = 6e-06
Identities = 63/226 (27%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYE--ERPRRCRDELEGPEPKGGNKLKQAS 321
+E+ +KL E A Q+ + E+ + ER R ELE + K + K
Sbjct: 2379 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2438
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
KS+ Q V Q QL QE + L+Q S + E+D L + R E+EK ++
Sbjct: 2439 LKSEEMQTV---QQEQLLQETQALQQ---SFLSEKDSLLQRERFIEQEKAKLEQLFQD-- 2490
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALR 441
E++ +Q +E Q + E L A +++ R R + E +R
Sbjct: 2491 --------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR-------RQHEAEEGVR 2535
Query: 442 TKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQ--AALA 485
K EL+ E Q+++ + ELL E+ L ++LQ L Q AALA
Sbjct: 2536 RKQEELQQLE---QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2578
Score = 44.3 bits (103), Expect = 3e-04
Identities = 72/340 (21%), Positives = 138/340 (40%), Gaps = 41/340 (12%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLA---------YEERPRRCRDELEGPEPKGG 314
Q + ++L + + L++++R E+ E A YE + + +LE P
Sbjct: 1210 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPA 1268
Query: 315 NKLKQASQKSQRAQQVLHL-----QVLQLQQEKRQLRQELESLMKEQDLLETKLRSYERE 369
K K S Q+ + L ++ L + + E M+E++ L + R+ ERE
Sbjct: 1269 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1328
Query: 370 KTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKAS-EILGLKAQLKDTRGKLEG 428
+ + A E Q +QL E+ + A+A E L+ ++++ + E
Sbjct: 1329 RLAEVEAALEKQ--------------RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1374
Query: 429 LELRTQDLEGALRTKGLEL-EVCENELQRKKNEAELLREKVNLLEQELQELRAQA-ALAR 486
+ Q + +++ + +L + E E+Q K +AE +E+E++ +R Q A R
Sbjct: 1375 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1434
Query: 487 DMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQL 546
G + EL+ LRA E Q + R ++E ++ Q + +L
Sbjct: 1435 QRG---------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1485
Query: 547 QQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADI 586
A + + ++ALQ L E E L A++
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1525
Score = 37.4 bits (85), Expect = 0.039
Identities = 63/282 (22%), Positives = 113/282 (40%), Gaps = 20/282 (7%)
Query: 324 SQRAQQVLHLQVLQLQQEKRQLR--QELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
S QQ+L Q+E R R EL+ + + + ET+ R PA E Q
Sbjct: 930 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 989
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGL----------KAQLKDTRGKLEGLEL 431
Q+ + + + L + ++A+A ++L L +++L+ T GKLE +
Sbjct: 990 RIAEQQKAQAEV--EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1047
Query: 432 RTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPP 491
+ L+T L + + + + E L+E + L EL A A + +
Sbjct: 1048 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE-AQAVPATLPELEATKASLKKLRA- 1105
Query: 492 TFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYV 551
A Q + LR ELR ++ +++ + + +E+V Q ++ Q
Sbjct: 1106 ----QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1161
Query: 552 AMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIA 593
R + LE+ +QL + +PL L+ A E I A
Sbjct: 1162 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1203
Score = 34.3 bits (77), Expect = 0.33
Identities = 47/219 (21%), Positives = 91/219 (41%), Gaps = 25/219 (11%)
Query: 263 IQELEQKLLEREGALQKLQRSF--EEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQA 320
+Q ++Q+ L +E Q LQ+SF E+ L + E+ + ++L E +L++
Sbjct: 2444 MQTVQQEQLLQE--TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2501
Query: 321 SQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEET 380
Q+ Q+ Q++QE+++L +E + Q E +R + E +
Sbjct: 2502 QQRQQQ----------QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2551
Query: 381 QWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLK-AQLKDTRGKLEGLELRTQDLEGA 439
+ + +++ + Q L+E A + E+ + A K + L+ + E
Sbjct: 2552 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2611
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
GL R+K A+ L+E L +ELQ L
Sbjct: 2612 HSFDGL----------RRKVSAQRLQEAGILSAEELQRL 2640
Score = 30.0 bits (66), Expect = 6.3
Identities = 39/157 (24%), Positives = 65/157 (41%), Gaps = 7/157 (4%)
Query: 359 LETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQ 418
LE +++ R+ G E + ++ G S QQL +S + + S ++
Sbjct: 897 LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISE 956
Query: 419 LKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
LKD R +LE E RT K E + +++K +AE V L + + L
Sbjct: 957 LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE-----VEGLGKGVARL 1011
Query: 479 RAQAALARDMGPPTFPEDVPALQRELERLRAELREER 515
A+A + P+ P L+ ELE +L + R
Sbjct: 1012 SAEAEKVLALPEPS--PAAPTLRSELELTLGKLEQVR 1046
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 77.0 bits (188), Expect = 4e-14
Identities = 81/318 (25%), Positives = 140/318 (44%), Gaps = 35/318 (11%)
Query: 271 LEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQV 330
+E E L + QR+ E + LA A E+ R+ + + + + K+ Q+ Q
Sbjct: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540
Query: 331 LHLQVLQLQQEKRQLRQELESLMKEQDL-LETKLRSYEREKTSFGPALEETQWEVCQKSG 389
+ QQ+KR +++EL+ L + + ++ K R E A E ++ +
Sbjct: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE--------AAERSRLRI---EE 1589
Query: 390 EISLLKQQLKESQTEVNAKASEILGLKAQLKDT-----RGKLEGLELRTQDLEGALRTKG 444
EI +++ QL+ ++ + E+ L+A+ ++ + + E LR Q + + R +
Sbjct: 1590 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1649
Query: 445 LELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQREL 504
E+E+ R K EAE REK L Q L+ELR QA A + Q E+
Sbjct: 1650 AEVELA----SRVKAEAEAAREKQRAL-QALEELRLQAEEA----------ERRLRQAEV 1694
Query: 505 ERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKAL 564
ER R + Q +R + EK Q ++ LQ+ +VA+ Q + E+
Sbjct: 1695 ERARQVQVALETAQRSAEAELQSKRASF---AEKTAQLERSLQEEHVAVAQLREEAERRA 1751
Query: 565 QQLARGDSAGEPLEVDLE 582
QQ A + A E E +LE
Sbjct: 1752 QQQAEAERAREEAERELE 1769
Score = 62.8 bits (151), Expect = 9e-10
Identities = 70/314 (22%), Positives = 131/314 (41%), Gaps = 19/314 (6%)
Query: 268 QKLLEREGALQKLQRSFEEKELASSLAYEERPRR--CRDELEGPEPKGGNKLKQASQKSQ 325
Q+ L+ E +K+++ EE S A E R ++L LK+ Q Q
Sbjct: 2400 QRFLQEEA--EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2457
Query: 326 RAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVC 385
A + L + LQQ+K +++ L ++++ + +L E F LE +
Sbjct: 2458 EATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQL 2513
Query: 386 QKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGL 445
+ S E LK ++ E + + Q ++ KL EL TQ+ K
Sbjct: 2514 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-------KVT 2566
Query: 446 ELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELE 505
++ E + Q+ ++AE LRE + LE+E ++L+ +A L + L +E +
Sbjct: 2567 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2626
Query: 506 RLRAELREERQGHDQMSSGFQHERL----VWKEEKEKVIQYQKQLQQSYVAMYQRNQRLE 561
L+ E+ Q + E+ ++++E K Q +++ Q+ M Q QRL
Sbjct: 2627 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2686
Query: 562 KALQQLARGDSAGE 575
++++ R E
Sbjct: 2687 ASMEEARRRQHEAE 2700
Score = 59.3 bits (142), Expect = 1e-08
Identities = 82/342 (23%), Positives = 152/342 (44%), Gaps = 46/342 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
+ +++ L E A ++ + + EE E A E RR R+ E + ++A+QK
Sbjct: 2125 ERVQKSLAAEEEAARQRKAALEEVERLK--AKVEEARRLRERAEQESARQLQLAQEAAQK 2182
Query: 324 SQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWE 383
+A++ H +QQ++++L+Q L+ +EQ +L+ +LR E + A EE +
Sbjct: 2183 RLQAEEKAH--AFAVQQKEQELQQTLQ---QEQSVLD-QLRG---EAEAARRAAEEAEEA 2233
Query: 384 VCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKL-----EGLELRTQDLEG 438
Q E + ++Q++E++ + A E +AQ + KL + R Q +
Sbjct: 2234 RVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2292
Query: 439 ALRTKGLELEVCENELQRKKNEAE-LLREKV--------------------NLLEQELQE 477
ALR K + + E+++ K AE LR+K NLL++ELQ
Sbjct: 2293 ALRQK----QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2348
Query: 478 LRAQAALARDMGPPTFPE--DVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEE 535
L+A+A A E V EL +L+A + E + + + + +EE
Sbjct: 2349 LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA--LILRDKDNTQRFLQEE 2406
Query: 536 KEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPL 577
EK+ Q ++ + VA + + + A + LA+ + E +
Sbjct: 2407 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2448
Score = 57.4 bits (137), Expect = 4e-08
Identities = 82/331 (24%), Positives = 140/331 (42%), Gaps = 22/331 (6%)
Query: 262 SIQELEQKLLE-REGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQA 320
SIQE Q+L + E +Q R E E S L EE R R +LE E + G +
Sbjct: 1554 SIQEELQQLRQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1612
Query: 321 SQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRS-------YEREKTSF 373
RA++ Q Q Q+E +LR++++ + + E +L S REK
Sbjct: 1613 QALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1671
Query: 374 GPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRT 433
ALEE + + + E L + +++ ++ A + +A+L+ R +T
Sbjct: 1672 LQALEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE---KT 1726
Query: 434 QDLEGALRTKGLELEVCENELQRK---KNEAELLREKVNLLEQELQELRAQAALARDMGP 490
LE +L+ + + + E +R+ + EAE RE+ E E +L+A AL +
Sbjct: 1727 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELERWQLKANEALRLRLQA 1785
Query: 491 PTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSY 550
+ Q E E+ + E E + + +R + ++E EK Q + Q
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1845
Query: 551 VAMYQRNQRLEKALQQLARGDSAGEPLEVDL 581
+A Q RL +Q G+ + LE +L
Sbjct: 1846 LAAEQELIRLRAETEQ---GEQQRQLLEEEL 1873
Score = 54.7 bits (130), Expect = 2e-07
Identities = 61/252 (24%), Positives = 113/252 (44%), Gaps = 23/252 (9%)
Query: 262 SIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQAS 321
++Q LE+ L+ E A ++L+++ E+ +A E R EL+ K Q
Sbjct: 1671 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL- 1729
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
+R+ Q H+ V QL++E + Q+ + ++ E +L ++ + + +
Sbjct: 1730 ---ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1786
Query: 382 WEVCQKSGEISLLKQQLKESQTEV--NAKASEILGLKAQLKDTRGKLEGLELRTQDLEGA 439
QKS + ++Q +E++ E KA E + +L + + LE + Q EG
Sbjct: 1787 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE-----QELEKQRQLAEGT 1841
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPA 499
+ + E EL R + E E ++ LLE+EL L+ +AA A +
Sbjct: 1842 AQQR----LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--------TQKRQE 1889
Query: 500 LQRELERLRAEL 511
L+ EL ++RAE+
Sbjct: 1890 LEAELAKVRAEM 1901
Score = 53.5 bits (127), Expect = 5e-07
Identities = 73/310 (23%), Positives = 138/310 (44%), Gaps = 28/310 (9%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
+ELE+ L+ AL +L+ EE SLA E ++ ++E E + G +QA ++
Sbjct: 1766 RELERWQLKANEAL-RLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQ 1823
Query: 324 SQRAQQVLHLQV----------LQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSF 373
+ A+Q L Q L +QE +LR E E +++ LLE +L +RE +
Sbjct: 1824 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1883
Query: 374 GPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRT 433
+E + E+ + E+ +L ++ E + + + K +L+ G+ L
Sbjct: 1884 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK---SKQRLEAEAGRFRELAEEA 1940
Query: 434 QDLEGALRTKGLELEVCENELQRKKNEAE-LLREKVNLLEQELQELRAQAAL------AR 486
L + ++ E + R++ EAE +L EK+ + E L+ +A + A
Sbjct: 1941 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKEAE 1999
Query: 487 DMGPPTFPEDVPALQRELERLRAELR---EERQGHDQMSSGFQHERLVWKEEKEKVIQYQ 543
+ ED +R LE A+ + EER + +S + ER K E ++ +
Sbjct: 2000 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER--QKGLVEDTLRQR 2057
Query: 544 KQLQQSYVAM 553
+Q+++ +A+
Sbjct: 2058 RQVEEEILAL 2067
Score = 51.2 bits (121), Expect = 3e-06
Identities = 73/335 (21%), Positives = 141/335 (42%), Gaps = 34/335 (10%)
Query: 267 EQKLLEREGALQKL--QRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKS 324
EQ + +RE A Q+L QR E LA E+ R R E E E + L++ +
Sbjct: 1818 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARL 1876
Query: 325 QRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEV 384
QR + +L+ E ++R E+E L+ + E + RS + A E+
Sbjct: 1877 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1936
Query: 385 CQKSGEISLLKQQLK-------ESQTEVNAKASEILGLK-------------AQLKDTRG 424
+++ + L ++ K E A+A +L K A++
Sbjct: 1937 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1996
Query: 425 KLEGLELRTQDLEGALRTKGLELEVCENELQ--------RKKNEAELLREKVNLLEQELQ 476
+ E LR + A + + LE + +++ RK +++EL R+K L+E L+
Sbjct: 1997 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-GLVEDTLR 2055
Query: 477 ELRA--QAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKE 534
+ R + LA L+ EL R+R+ + + +Q +R + E
Sbjct: 2056 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 2115
Query: 535 EKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLAR 569
E+ + + ++++Q+S A + ++ + AL+++ R
Sbjct: 2116 EERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150
Score = 50.1 bits (118), Expect = 6e-06
Identities = 63/226 (27%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYE--ERPRRCRDELEGPEPKGGNKLKQAS 321
+E+ +KL E A Q+ + E+ + ER R ELE + K + K
Sbjct: 2548 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2607
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
KS+ Q V Q QL QE + L+Q S + E+D L + R E+EK ++
Sbjct: 2608 LKSEEMQTV---QQEQLLQETQALQQ---SFLSEKDSLLQRERFIEQEKAKLEQLFQD-- 2659
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALR 441
E++ +Q +E Q + E L A +++ R R + E +R
Sbjct: 2660 --------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR-------RQHEAEEGVR 2704
Query: 442 TKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQ--AALA 485
K EL+ E Q+++ + ELL E+ L ++LQ L Q AALA
Sbjct: 2705 RKQEELQQLE---QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2747
Score = 44.3 bits (103), Expect = 3e-04
Identities = 72/340 (21%), Positives = 138/340 (40%), Gaps = 41/340 (12%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLA---------YEERPRRCRDELEGPEPKGG 314
Q + ++L + + L++++R E+ E A YE + + +LE P
Sbjct: 1379 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPA 1437
Query: 315 NKLKQASQKSQRAQQVLHL-----QVLQLQQEKRQLRQELESLMKEQDLLETKLRSYERE 369
K K S Q+ + L ++ L + + E M+E++ L + R+ ERE
Sbjct: 1438 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1497
Query: 370 KTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKAS-EILGLKAQLKDTRGKLEG 428
+ + A E Q +QL E+ + A+A E L+ ++++ + E
Sbjct: 1498 RLAEVEAALEKQ--------------RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1543
Query: 429 LELRTQDLEGALRTKGLEL-EVCENELQRKKNEAELLREKVNLLEQELQELRAQA-ALAR 486
+ Q + +++ + +L + E E+Q K +AE +E+E++ +R Q A R
Sbjct: 1544 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1603
Query: 487 DMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQL 546
G + EL+ LRA E Q + R ++E ++ Q + +L
Sbjct: 1604 QRG---------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1654
Query: 547 QQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADI 586
A + + ++ALQ L E E L A++
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1694
Score = 37.4 bits (85), Expect = 0.039
Identities = 63/282 (22%), Positives = 113/282 (40%), Gaps = 20/282 (7%)
Query: 324 SQRAQQVLHLQVLQLQQEKRQLR--QELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
S QQ+L Q+E R R EL+ + + + ET+ R PA E Q
Sbjct: 1099 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 1158
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGL----------KAQLKDTRGKLEGLEL 431
Q+ + + + L + ++A+A ++L L +++L+ T GKLE +
Sbjct: 1159 RIAEQQKAQAEV--EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1216
Query: 432 RTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPP 491
+ L+T L + + + + E L+E + L EL A A + +
Sbjct: 1217 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE-AQAVPATLPELEATKASLKKLRA- 1274
Query: 492 TFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYV 551
A Q + LR ELR ++ +++ + + +E+V Q ++ Q
Sbjct: 1275 ----QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1330
Query: 552 AMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIA 593
R + LE+ +QL + +PL L+ A E I A
Sbjct: 1331 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1372
Score = 34.3 bits (77), Expect = 0.33
Identities = 47/219 (21%), Positives = 91/219 (41%), Gaps = 25/219 (11%)
Query: 263 IQELEQKLLEREGALQKLQRSF--EEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQA 320
+Q ++Q+ L +E Q LQ+SF E+ L + E+ + ++L E +L++
Sbjct: 2613 MQTVQQEQLLQE--TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2670
Query: 321 SQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEET 380
Q+ Q+ Q++QE+++L +E + Q E +R + E +
Sbjct: 2671 QQRQQQ----------QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2720
Query: 381 QWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLK-AQLKDTRGKLEGLELRTQDLEGA 439
+ + +++ + Q L+E A + E+ + A K + L+ + E
Sbjct: 2721 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2780
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
GL R+K A+ L+E L +ELQ L
Sbjct: 2781 HSFDGL----------RRKVSAQRLQEAGILSAEELQRL 2809
Score = 30.0 bits (66), Expect = 6.3
Identities = 39/157 (24%), Positives = 65/157 (41%), Gaps = 7/157 (4%)
Query: 359 LETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQ 418
LE +++ R+ G E + ++ G S QQL +S + + S ++
Sbjct: 1066 LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISE 1125
Query: 419 LKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
LKD R +LE E RT K E + +++K +AE V L + + L
Sbjct: 1126 LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE-----VEGLGKGVARL 1180
Query: 479 RAQAALARDMGPPTFPEDVPALQRELERLRAELREER 515
A+A + P+ P L+ ELE +L + R
Sbjct: 1181 SAEAEKVLALPEPS--PAAPTLRSELELTLGKLEQVR 1215
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 77.0 bits (188), Expect = 4e-14
Identities = 81/318 (25%), Positives = 140/318 (44%), Gaps = 35/318 (11%)
Query: 271 LEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQV 330
+E E L + QR+ E + LA A E+ R+ + + + + K+ Q+ Q
Sbjct: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381
Query: 331 LHLQVLQLQQEKRQLRQELESLMKEQDL-LETKLRSYEREKTSFGPALEETQWEVCQKSG 389
+ QQ+KR +++EL+ L + + ++ K R E A E ++ +
Sbjct: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE--------AAERSRLRI---EE 1430
Query: 390 EISLLKQQLKESQTEVNAKASEILGLKAQLKDT-----RGKLEGLELRTQDLEGALRTKG 444
EI +++ QL+ ++ + E+ L+A+ ++ + + E LR Q + + R +
Sbjct: 1431 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1490
Query: 445 LELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQREL 504
E+E+ R K EAE REK L Q L+ELR QA A + Q E+
Sbjct: 1491 AEVELA----SRVKAEAEAAREKQRAL-QALEELRLQAEEA----------ERRLRQAEV 1535
Query: 505 ERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKAL 564
ER R + Q +R + EK Q ++ LQ+ +VA+ Q + E+
Sbjct: 1536 ERARQVQVALETAQRSAEAELQSKRASF---AEKTAQLERSLQEEHVAVAQLREEAERRA 1592
Query: 565 QQLARGDSAGEPLEVDLE 582
QQ A + A E E +LE
Sbjct: 1593 QQQAEAERAREEAERELE 1610
Score = 62.8 bits (151), Expect = 9e-10
Identities = 70/314 (22%), Positives = 131/314 (41%), Gaps = 19/314 (6%)
Query: 268 QKLLEREGALQKLQRSFEEKELASSLAYEERPRR--CRDELEGPEPKGGNKLKQASQKSQ 325
Q+ L+ E +K+++ EE S A E R ++L LK+ Q Q
Sbjct: 2241 QRFLQEEA--EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2298
Query: 326 RAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVC 385
A + L + LQQ+K +++ L ++++ + +L E F LE +
Sbjct: 2299 EATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQL 2354
Query: 386 QKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGL 445
+ S E LK ++ E + + Q ++ KL EL TQ+ K
Sbjct: 2355 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-------KVT 2407
Query: 446 ELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELE 505
++ E + Q+ ++AE LRE + LE+E ++L+ +A L + L +E +
Sbjct: 2408 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2467
Query: 506 RLRAELREERQGHDQMSSGFQHERL----VWKEEKEKVIQYQKQLQQSYVAMYQRNQRLE 561
L+ E+ Q + E+ ++++E K Q +++ Q+ M Q QRL
Sbjct: 2468 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2527
Query: 562 KALQQLARGDSAGE 575
++++ R E
Sbjct: 2528 ASMEEARRRQHEAE 2541
Score = 59.3 bits (142), Expect = 1e-08
Identities = 82/342 (23%), Positives = 152/342 (44%), Gaps = 46/342 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
+ +++ L E A ++ + + EE E A E RR R+ E + ++A+QK
Sbjct: 1966 ERVQKSLAAEEEAARQRKAALEEVERLK--AKVEEARRLRERAEQESARQLQLAQEAAQK 2023
Query: 324 SQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWE 383
+A++ H +QQ++++L+Q L+ +EQ +L+ +LR E + A EE +
Sbjct: 2024 RLQAEEKAH--AFAVQQKEQELQQTLQ---QEQSVLD-QLRG---EAEAARRAAEEAEEA 2074
Query: 384 VCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKL-----EGLELRTQDLEG 438
Q E + ++Q++E++ + A E +AQ + KL + R Q +
Sbjct: 2075 RVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2133
Query: 439 ALRTKGLELEVCENELQRKKNEAE-LLREKV--------------------NLLEQELQE 477
ALR K + + E+++ K AE LR+K NLL++ELQ
Sbjct: 2134 ALRQK----QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2189
Query: 478 LRAQAALARDMGPPTFPE--DVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEE 535
L+A+A A E V EL +L+A + E + + + + +EE
Sbjct: 2190 LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA--LILRDKDNTQRFLQEE 2247
Query: 536 KEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPL 577
EK+ Q ++ + VA + + + A + LA+ + E +
Sbjct: 2248 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2289
Score = 57.4 bits (137), Expect = 4e-08
Identities = 82/331 (24%), Positives = 140/331 (42%), Gaps = 22/331 (6%)
Query: 262 SIQELEQKLLE-REGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQA 320
SIQE Q+L + E +Q R E E S L EE R R +LE E + G +
Sbjct: 1395 SIQEELQQLRQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1453
Query: 321 SQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRS-------YEREKTSF 373
RA++ Q Q Q+E +LR++++ + + E +L S REK
Sbjct: 1454 QALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1512
Query: 374 GPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRT 433
ALEE + + + E L + +++ ++ A + +A+L+ R +T
Sbjct: 1513 LQALEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE---KT 1567
Query: 434 QDLEGALRTKGLELEVCENELQRK---KNEAELLREKVNLLEQELQELRAQAALARDMGP 490
LE +L+ + + + E +R+ + EAE RE+ E E +L+A AL +
Sbjct: 1568 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELERWQLKANEALRLRLQA 1626
Query: 491 PTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSY 550
+ Q E E+ + E E + + +R + ++E EK Q + Q
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1686
Query: 551 VAMYQRNQRLEKALQQLARGDSAGEPLEVDL 581
+A Q RL +Q G+ + LE +L
Sbjct: 1687 LAAEQELIRLRAETEQ---GEQQRQLLEEEL 1714
Score = 54.7 bits (130), Expect = 2e-07
Identities = 61/252 (24%), Positives = 113/252 (44%), Gaps = 23/252 (9%)
Query: 262 SIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQAS 321
++Q LE+ L+ E A ++L+++ E+ +A E R EL+ K Q
Sbjct: 1512 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL- 1570
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
+R+ Q H+ V QL++E + Q+ + ++ E +L ++ + + +
Sbjct: 1571 ---ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1627
Query: 382 WEVCQKSGEISLLKQQLKESQTEV--NAKASEILGLKAQLKDTRGKLEGLELRTQDLEGA 439
QKS + ++Q +E++ E KA E + +L + + LE + Q EG
Sbjct: 1628 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE-----QELEKQRQLAEGT 1682
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPA 499
+ + E EL R + E E ++ LLE+EL L+ +AA A +
Sbjct: 1683 AQQR----LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--------TQKRQE 1730
Query: 500 LQRELERLRAEL 511
L+ EL ++RAE+
Sbjct: 1731 LEAELAKVRAEM 1742
Score = 53.5 bits (127), Expect = 5e-07
Identities = 73/310 (23%), Positives = 138/310 (44%), Gaps = 28/310 (9%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
+ELE+ L+ AL +L+ EE SLA E ++ ++E E + G +QA ++
Sbjct: 1607 RELERWQLKANEAL-RLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQ 1664
Query: 324 SQRAQQVLHLQV----------LQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSF 373
+ A+Q L Q L +QE +LR E E +++ LLE +L +RE +
Sbjct: 1665 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1724
Query: 374 GPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRT 433
+E + E+ + E+ +L ++ E + + + K +L+ G+ L
Sbjct: 1725 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK---SKQRLEAEAGRFRELAEEA 1781
Query: 434 QDLEGALRTKGLELEVCENELQRKKNEAE-LLREKVNLLEQELQELRAQAAL------AR 486
L + ++ E + R++ EAE +L EK+ + E L+ +A + A
Sbjct: 1782 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKEAE 1840
Query: 487 DMGPPTFPEDVPALQRELERLRAELR---EERQGHDQMSSGFQHERLVWKEEKEKVIQYQ 543
+ ED +R LE A+ + EER + +S + ER K E ++ +
Sbjct: 1841 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER--QKGLVEDTLRQR 1898
Query: 544 KQLQQSYVAM 553
+Q+++ +A+
Sbjct: 1899 RQVEEEILAL 1908
Score = 51.2 bits (121), Expect = 3e-06
Identities = 73/335 (21%), Positives = 141/335 (42%), Gaps = 34/335 (10%)
Query: 267 EQKLLEREGALQKL--QRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKS 324
EQ + +RE A Q+L QR E LA E+ R R E E E + L++ +
Sbjct: 1659 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARL 1717
Query: 325 QRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEV 384
QR + +L+ E ++R E+E L+ + E + RS + A E+
Sbjct: 1718 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1777
Query: 385 CQKSGEISLLKQQLK-------ESQTEVNAKASEILGLK-------------AQLKDTRG 424
+++ + L ++ K E A+A +L K A++
Sbjct: 1778 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1837
Query: 425 KLEGLELRTQDLEGALRTKGLELEVCENELQ--------RKKNEAELLREKVNLLEQELQ 476
+ E LR + A + + LE + +++ RK +++EL R+K L+E L+
Sbjct: 1838 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-GLVEDTLR 1896
Query: 477 ELRA--QAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKE 534
+ R + LA L+ EL R+R+ + + +Q +R + E
Sbjct: 1897 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1956
Query: 535 EKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLAR 569
E+ + + ++++Q+S A + ++ + AL+++ R
Sbjct: 1957 EERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991
Score = 50.1 bits (118), Expect = 6e-06
Identities = 63/226 (27%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYE--ERPRRCRDELEGPEPKGGNKLKQAS 321
+E+ +KL E A Q+ + E+ + ER R ELE + K + K
Sbjct: 2389 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2448
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
KS+ Q V Q QL QE + L+Q S + E+D L + R E+EK ++
Sbjct: 2449 LKSEEMQTV---QQEQLLQETQALQQ---SFLSEKDSLLQRERFIEQEKAKLEQLFQD-- 2500
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALR 441
E++ +Q +E Q + E L A +++ R R + E +R
Sbjct: 2501 --------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR-------RQHEAEEGVR 2545
Query: 442 TKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQ--AALA 485
K EL+ E Q+++ + ELL E+ L ++LQ L Q AALA
Sbjct: 2546 RKQEELQQLE---QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2588
Score = 44.3 bits (103), Expect = 3e-04
Identities = 72/340 (21%), Positives = 138/340 (40%), Gaps = 41/340 (12%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLA---------YEERPRRCRDELEGPEPKGG 314
Q + ++L + + L++++R E+ E A YE + + +LE P
Sbjct: 1220 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPA 1278
Query: 315 NKLKQASQKSQRAQQVLHL-----QVLQLQQEKRQLRQELESLMKEQDLLETKLRSYERE 369
K K S Q+ + L ++ L + + E M+E++ L + R+ ERE
Sbjct: 1279 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1338
Query: 370 KTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKAS-EILGLKAQLKDTRGKLEG 428
+ + A E Q +QL E+ + A+A E L+ ++++ + E
Sbjct: 1339 RLAEVEAALEKQ--------------RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1384
Query: 429 LELRTQDLEGALRTKGLEL-EVCENELQRKKNEAELLREKVNLLEQELQELRAQA-ALAR 486
+ Q + +++ + +L + E E+Q K +AE +E+E++ +R Q A R
Sbjct: 1385 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1444
Query: 487 DMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQL 546
G + EL+ LRA E Q + R ++E ++ Q + +L
Sbjct: 1445 QRG---------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1495
Query: 547 QQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADI 586
A + + ++ALQ L E E L A++
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1535
Score = 37.4 bits (85), Expect = 0.039
Identities = 63/282 (22%), Positives = 113/282 (40%), Gaps = 20/282 (7%)
Query: 324 SQRAQQVLHLQVLQLQQEKRQLR--QELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
S QQ+L Q+E R R EL+ + + + ET+ R PA E Q
Sbjct: 940 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 999
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGL----------KAQLKDTRGKLEGLEL 431
Q+ + + + L + ++A+A ++L L +++L+ T GKLE +
Sbjct: 1000 RIAEQQKAQAEV--EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1057
Query: 432 RTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPP 491
+ L+T L + + + + E L+E + L EL A A + +
Sbjct: 1058 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE-AQAVPATLPELEATKASLKKLRA- 1115
Query: 492 TFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYV 551
A Q + LR ELR ++ +++ + + +E+V Q ++ Q
Sbjct: 1116 ----QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1171
Query: 552 AMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIA 593
R + LE+ +QL + +PL L+ A E I A
Sbjct: 1172 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1213
Score = 34.3 bits (77), Expect = 0.33
Identities = 47/219 (21%), Positives = 91/219 (41%), Gaps = 25/219 (11%)
Query: 263 IQELEQKLLEREGALQKLQRSF--EEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQA 320
+Q ++Q+ L +E Q LQ+SF E+ L + E+ + ++L E +L++
Sbjct: 2454 MQTVQQEQLLQE--TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2511
Query: 321 SQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEET 380
Q+ Q+ Q++QE+++L +E + Q E +R + E +
Sbjct: 2512 QQRQQQ----------QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2561
Query: 381 QWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLK-AQLKDTRGKLEGLELRTQDLEGA 439
+ + +++ + Q L+E A + E+ + A K + L+ + E
Sbjct: 2562 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2621
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
GL R+K A+ L+E L +ELQ L
Sbjct: 2622 HSFDGL----------RRKVSAQRLQEAGILSAEELQRL 2650
Score = 30.0 bits (66), Expect = 6.3
Identities = 39/157 (24%), Positives = 65/157 (41%), Gaps = 7/157 (4%)
Query: 359 LETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQ 418
LE +++ R+ G E + ++ G S QQL +S + + S ++
Sbjct: 907 LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISE 966
Query: 419 LKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
LKD R +LE E RT K E + +++K +AE V L + + L
Sbjct: 967 LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE-----VEGLGKGVARL 1021
Query: 479 RAQAALARDMGPPTFPEDVPALQRELERLRAELREER 515
A+A + P+ P L+ ELE +L + R
Sbjct: 1022 SAEAEKVLALPEPS--PAAPTLRSELELTLGKLEQVR 1056
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 77.0 bits (188), Expect = 4e-14
Identities = 81/318 (25%), Positives = 140/318 (44%), Gaps = 35/318 (11%)
Query: 271 LEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQV 330
+E E L + QR+ E + LA A E+ R+ + + + + K+ Q+ Q
Sbjct: 1330 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1389
Query: 331 LHLQVLQLQQEKRQLRQELESLMKEQDL-LETKLRSYEREKTSFGPALEETQWEVCQKSG 389
+ QQ+KR +++EL+ L + + ++ K R E A E ++ +
Sbjct: 1390 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE--------AAERSRLRI---EE 1438
Query: 390 EISLLKQQLKESQTEVNAKASEILGLKAQLKDT-----RGKLEGLELRTQDLEGALRTKG 444
EI +++ QL+ ++ + E+ L+A+ ++ + + E LR Q + + R +
Sbjct: 1439 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1498
Query: 445 LELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQREL 504
E+E+ R K EAE REK L Q L+ELR QA A + Q E+
Sbjct: 1499 AEVELA----SRVKAEAEAAREKQRAL-QALEELRLQAEEA----------ERRLRQAEV 1543
Query: 505 ERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKAL 564
ER R + Q +R + EK Q ++ LQ+ +VA+ Q + E+
Sbjct: 1544 ERARQVQVALETAQRSAEAELQSKRASF---AEKTAQLERSLQEEHVAVAQLREEAERRA 1600
Query: 565 QQLARGDSAGEPLEVDLE 582
QQ A + A E E +LE
Sbjct: 1601 QQQAEAERAREEAERELE 1618
Score = 62.8 bits (151), Expect = 9e-10
Identities = 70/314 (22%), Positives = 131/314 (41%), Gaps = 19/314 (6%)
Query: 268 QKLLEREGALQKLQRSFEEKELASSLAYEERPRR--CRDELEGPEPKGGNKLKQASQKSQ 325
Q+ L+ E +K+++ EE S A E R ++L LK+ Q Q
Sbjct: 2249 QRFLQEEA--EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2306
Query: 326 RAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVC 385
A + L + LQQ+K +++ L ++++ + +L E F LE +
Sbjct: 2307 EATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQL 2362
Query: 386 QKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGL 445
+ S E LK ++ E + + Q ++ KL EL TQ+ K
Sbjct: 2363 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-------KVT 2415
Query: 446 ELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELE 505
++ E + Q+ ++AE LRE + LE+E ++L+ +A L + L +E +
Sbjct: 2416 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2475
Query: 506 RLRAELREERQGHDQMSSGFQHERL----VWKEEKEKVIQYQKQLQQSYVAMYQRNQRLE 561
L+ E+ Q + E+ ++++E K Q +++ Q+ M Q QRL
Sbjct: 2476 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2535
Query: 562 KALQQLARGDSAGE 575
++++ R E
Sbjct: 2536 ASMEEARRRQHEAE 2549
Score = 59.3 bits (142), Expect = 1e-08
Identities = 82/342 (23%), Positives = 152/342 (44%), Gaps = 46/342 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
+ +++ L E A ++ + + EE E A E RR R+ E + ++A+QK
Sbjct: 1974 ERVQKSLAAEEEAARQRKAALEEVERLK--AKVEEARRLRERAEQESARQLQLAQEAAQK 2031
Query: 324 SQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWE 383
+A++ H +QQ++++L+Q L+ +EQ +L+ +LR E + A EE +
Sbjct: 2032 RLQAEEKAH--AFAVQQKEQELQQTLQ---QEQSVLD-QLRG---EAEAARRAAEEAEEA 2082
Query: 384 VCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKL-----EGLELRTQDLEG 438
Q E + ++Q++E++ + A E +AQ + KL + R Q +
Sbjct: 2083 RVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2141
Query: 439 ALRTKGLELEVCENELQRKKNEAE-LLREKV--------------------NLLEQELQE 477
ALR K + + E+++ K AE LR+K NLL++ELQ
Sbjct: 2142 ALRQK----QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2197
Query: 478 LRAQAALARDMGPPTFPE--DVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEE 535
L+A+A A E V EL +L+A + E + + + + +EE
Sbjct: 2198 LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA--LILRDKDNTQRFLQEE 2255
Query: 536 KEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPL 577
EK+ Q ++ + VA + + + A + LA+ + E +
Sbjct: 2256 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2297
Score = 57.4 bits (137), Expect = 4e-08
Identities = 82/331 (24%), Positives = 140/331 (42%), Gaps = 22/331 (6%)
Query: 262 SIQELEQKLLE-REGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQA 320
SIQE Q+L + E +Q R E E S L EE R R +LE E + G +
Sbjct: 1403 SIQEELQQLRQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1461
Query: 321 SQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRS-------YEREKTSF 373
RA++ Q Q Q+E +LR++++ + + E +L S REK
Sbjct: 1462 QALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1520
Query: 374 GPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRT 433
ALEE + + + E L + +++ ++ A + +A+L+ R +T
Sbjct: 1521 LQALEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE---KT 1575
Query: 434 QDLEGALRTKGLELEVCENELQRK---KNEAELLREKVNLLEQELQELRAQAALARDMGP 490
LE +L+ + + + E +R+ + EAE RE+ E E +L+A AL +
Sbjct: 1576 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELERWQLKANEALRLRLQA 1634
Query: 491 PTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSY 550
+ Q E E+ + E E + + +R + ++E EK Q + Q
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1694
Query: 551 VAMYQRNQRLEKALQQLARGDSAGEPLEVDL 581
+A Q RL +Q G+ + LE +L
Sbjct: 1695 LAAEQELIRLRAETEQ---GEQQRQLLEEEL 1722
Score = 54.7 bits (130), Expect = 2e-07
Identities = 61/252 (24%), Positives = 113/252 (44%), Gaps = 23/252 (9%)
Query: 262 SIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQAS 321
++Q LE+ L+ E A ++L+++ E+ +A E R EL+ K Q
Sbjct: 1520 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL- 1578
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
+R+ Q H+ V QL++E + Q+ + ++ E +L ++ + + +
Sbjct: 1579 ---ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1635
Query: 382 WEVCQKSGEISLLKQQLKESQTEV--NAKASEILGLKAQLKDTRGKLEGLELRTQDLEGA 439
QKS + ++Q +E++ E KA E + +L + + LE + Q EG
Sbjct: 1636 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE-----QELEKQRQLAEGT 1690
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPA 499
+ + E EL R + E E ++ LLE+EL L+ +AA A +
Sbjct: 1691 AQQR----LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--------TQKRQE 1738
Query: 500 LQRELERLRAEL 511
L+ EL ++RAE+
Sbjct: 1739 LEAELAKVRAEM 1750
Score = 53.5 bits (127), Expect = 5e-07
Identities = 73/310 (23%), Positives = 138/310 (44%), Gaps = 28/310 (9%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
+ELE+ L+ AL +L+ EE SLA E ++ ++E E + G +QA ++
Sbjct: 1615 RELERWQLKANEAL-RLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQ 1672
Query: 324 SQRAQQVLHLQV----------LQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSF 373
+ A+Q L Q L +QE +LR E E +++ LLE +L +RE +
Sbjct: 1673 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1732
Query: 374 GPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRT 433
+E + E+ + E+ +L ++ E + + + K +L+ G+ L
Sbjct: 1733 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK---SKQRLEAEAGRFRELAEEA 1789
Query: 434 QDLEGALRTKGLELEVCENELQRKKNEAE-LLREKVNLLEQELQELRAQAAL------AR 486
L + ++ E + R++ EAE +L EK+ + E L+ +A + A
Sbjct: 1790 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKEAE 1848
Query: 487 DMGPPTFPEDVPALQRELERLRAELR---EERQGHDQMSSGFQHERLVWKEEKEKVIQYQ 543
+ ED +R LE A+ + EER + +S + ER K E ++ +
Sbjct: 1849 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER--QKGLVEDTLRQR 1906
Query: 544 KQLQQSYVAM 553
+Q+++ +A+
Sbjct: 1907 RQVEEEILAL 1916
Score = 51.2 bits (121), Expect = 3e-06
Identities = 73/335 (21%), Positives = 141/335 (42%), Gaps = 34/335 (10%)
Query: 267 EQKLLEREGALQKL--QRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKS 324
EQ + +RE A Q+L QR E LA E+ R R E E E + L++ +
Sbjct: 1667 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARL 1725
Query: 325 QRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEV 384
QR + +L+ E ++R E+E L+ + E + RS + A E+
Sbjct: 1726 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1785
Query: 385 CQKSGEISLLKQQLK-------ESQTEVNAKASEILGLK-------------AQLKDTRG 424
+++ + L ++ K E A+A +L K A++
Sbjct: 1786 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1845
Query: 425 KLEGLELRTQDLEGALRTKGLELEVCENELQ--------RKKNEAELLREKVNLLEQELQ 476
+ E LR + A + + LE + +++ RK +++EL R+K L+E L+
Sbjct: 1846 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-GLVEDTLR 1904
Query: 477 ELRA--QAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKE 534
+ R + LA L+ EL R+R+ + + +Q +R + E
Sbjct: 1905 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1964
Query: 535 EKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLAR 569
E+ + + ++++Q+S A + ++ + AL+++ R
Sbjct: 1965 EERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1999
Score = 50.1 bits (118), Expect = 6e-06
Identities = 63/226 (27%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYE--ERPRRCRDELEGPEPKGGNKLKQAS 321
+E+ +KL E A Q+ + E+ + ER R ELE + K + K
Sbjct: 2397 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2456
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
KS+ Q V Q QL QE + L+Q S + E+D L + R E+EK ++
Sbjct: 2457 LKSEEMQTV---QQEQLLQETQALQQ---SFLSEKDSLLQRERFIEQEKAKLEQLFQD-- 2508
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALR 441
E++ +Q +E Q + E L A +++ R R + E +R
Sbjct: 2509 --------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR-------RQHEAEEGVR 2553
Query: 442 TKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQ--AALA 485
K EL+ E Q+++ + ELL E+ L ++LQ L Q AALA
Sbjct: 2554 RKQEELQQLE---QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2596
Score = 44.3 bits (103), Expect = 3e-04
Identities = 72/340 (21%), Positives = 138/340 (40%), Gaps = 41/340 (12%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLA---------YEERPRRCRDELEGPEPKGG 314
Q + ++L + + L++++R E+ E A YE + + +LE P
Sbjct: 1228 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPA 1286
Query: 315 NKLKQASQKSQRAQQVLHL-----QVLQLQQEKRQLRQELESLMKEQDLLETKLRSYERE 369
K K S Q+ + L ++ L + + E M+E++ L + R+ ERE
Sbjct: 1287 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1346
Query: 370 KTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKAS-EILGLKAQLKDTRGKLEG 428
+ + A E Q +QL E+ + A+A E L+ ++++ + E
Sbjct: 1347 RLAEVEAALEKQ--------------RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1392
Query: 429 LELRTQDLEGALRTKGLEL-EVCENELQRKKNEAELLREKVNLLEQELQELRAQA-ALAR 486
+ Q + +++ + +L + E E+Q K +AE +E+E++ +R Q A R
Sbjct: 1393 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1452
Query: 487 DMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQL 546
G + EL+ LRA E Q + R ++E ++ Q + +L
Sbjct: 1453 QRG---------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1503
Query: 547 QQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADI 586
A + + ++ALQ L E E L A++
Sbjct: 1504 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1543
Score = 37.4 bits (85), Expect = 0.039
Identities = 63/282 (22%), Positives = 113/282 (40%), Gaps = 20/282 (7%)
Query: 324 SQRAQQVLHLQVLQLQQEKRQLR--QELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
S QQ+L Q+E R R EL+ + + + ET+ R PA E Q
Sbjct: 948 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 1007
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGL----------KAQLKDTRGKLEGLEL 431
Q+ + + + L + ++A+A ++L L +++L+ T GKLE +
Sbjct: 1008 RIAEQQKAQAEV--EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1065
Query: 432 RTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPP 491
+ L+T L + + + + E L+E + L EL A A + +
Sbjct: 1066 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE-AQAVPATLPELEATKASLKKLRA- 1123
Query: 492 TFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYV 551
A Q + LR ELR ++ +++ + + +E+V Q ++ Q
Sbjct: 1124 ----QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1179
Query: 552 AMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIA 593
R + LE+ +QL + +PL L+ A E I A
Sbjct: 1180 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1221
Score = 34.3 bits (77), Expect = 0.33
Identities = 47/219 (21%), Positives = 91/219 (41%), Gaps = 25/219 (11%)
Query: 263 IQELEQKLLEREGALQKLQRSF--EEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQA 320
+Q ++Q+ L +E Q LQ+SF E+ L + E+ + ++L E +L++
Sbjct: 2462 MQTVQQEQLLQE--TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2519
Query: 321 SQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEET 380
Q+ Q+ Q++QE+++L +E + Q E +R + E +
Sbjct: 2520 QQRQQQ----------QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2569
Query: 381 QWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLK-AQLKDTRGKLEGLELRTQDLEGA 439
+ + +++ + Q L+E A + E+ + A K + L+ + E
Sbjct: 2570 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2629
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
GL R+K A+ L+E L +ELQ L
Sbjct: 2630 HSFDGL----------RRKVSAQRLQEAGILSAEELQRL 2658
Score = 30.0 bits (66), Expect = 6.3
Identities = 39/157 (24%), Positives = 65/157 (41%), Gaps = 7/157 (4%)
Query: 359 LETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQ 418
LE +++ R+ G E + ++ G S QQL +S + + S ++
Sbjct: 915 LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISE 974
Query: 419 LKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
LKD R +LE E RT K E + +++K +AE V L + + L
Sbjct: 975 LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE-----VEGLGKGVARL 1029
Query: 479 RAQAALARDMGPPTFPEDVPALQRELERLRAELREER 515
A+A + P+ P L+ ELE +L + R
Sbjct: 1030 SAEAEKVLALPEPS--PAAPTLRSELELTLGKLEQVR 1064
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 77.0 bits (188), Expect = 4e-14
Identities = 81/318 (25%), Positives = 140/318 (44%), Gaps = 35/318 (11%)
Query: 271 LEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQV 330
+E E L + QR+ E + LA A E+ R+ + + + + K+ Q+ Q
Sbjct: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430
Query: 331 LHLQVLQLQQEKRQLRQELESLMKEQDL-LETKLRSYEREKTSFGPALEETQWEVCQKSG 389
+ QQ+KR +++EL+ L + + ++ K R E A E ++ +
Sbjct: 1431 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE--------AAERSRLRI---EE 1479
Query: 390 EISLLKQQLKESQTEVNAKASEILGLKAQLKDT-----RGKLEGLELRTQDLEGALRTKG 444
EI +++ QL+ ++ + E+ L+A+ ++ + + E LR Q + + R +
Sbjct: 1480 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1539
Query: 445 LELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQREL 504
E+E+ R K EAE REK L Q L+ELR QA A + Q E+
Sbjct: 1540 AEVELA----SRVKAEAEAAREKQRAL-QALEELRLQAEEA----------ERRLRQAEV 1584
Query: 505 ERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKAL 564
ER R + Q +R + EK Q ++ LQ+ +VA+ Q + E+
Sbjct: 1585 ERARQVQVALETAQRSAEAELQSKRASF---AEKTAQLERSLQEEHVAVAQLREEAERRA 1641
Query: 565 QQLARGDSAGEPLEVDLE 582
QQ A + A E E +LE
Sbjct: 1642 QQQAEAERAREEAERELE 1659
Score = 62.8 bits (151), Expect = 9e-10
Identities = 70/314 (22%), Positives = 131/314 (41%), Gaps = 19/314 (6%)
Query: 268 QKLLEREGALQKLQRSFEEKELASSLAYEERPRR--CRDELEGPEPKGGNKLKQASQKSQ 325
Q+ L+ E +K+++ EE S A E R ++L LK+ Q Q
Sbjct: 2290 QRFLQEEA--EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2347
Query: 326 RAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVC 385
A + L + LQQ+K +++ L ++++ + +L E F LE +
Sbjct: 2348 EATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQL 2403
Query: 386 QKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGL 445
+ S E LK ++ E + + Q ++ KL EL TQ+ K
Sbjct: 2404 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-------KVT 2456
Query: 446 ELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELE 505
++ E + Q+ ++AE LRE + LE+E ++L+ +A L + L +E +
Sbjct: 2457 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2516
Query: 506 RLRAELREERQGHDQMSSGFQHERL----VWKEEKEKVIQYQKQLQQSYVAMYQRNQRLE 561
L+ E+ Q + E+ ++++E K Q +++ Q+ M Q QRL
Sbjct: 2517 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2576
Query: 562 KALQQLARGDSAGE 575
++++ R E
Sbjct: 2577 ASMEEARRRQHEAE 2590
Score = 59.3 bits (142), Expect = 1e-08
Identities = 82/342 (23%), Positives = 152/342 (44%), Gaps = 46/342 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
+ +++ L E A ++ + + EE E A E RR R+ E + ++A+QK
Sbjct: 2015 ERVQKSLAAEEEAARQRKAALEEVERLK--AKVEEARRLRERAEQESARQLQLAQEAAQK 2072
Query: 324 SQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWE 383
+A++ H +QQ++++L+Q L+ +EQ +L+ +LR E + A EE +
Sbjct: 2073 RLQAEEKAH--AFAVQQKEQELQQTLQ---QEQSVLD-QLRG---EAEAARRAAEEAEEA 2123
Query: 384 VCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKL-----EGLELRTQDLEG 438
Q E + ++Q++E++ + A E +AQ + KL + R Q +
Sbjct: 2124 RVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2182
Query: 439 ALRTKGLELEVCENELQRKKNEAE-LLREKV--------------------NLLEQELQE 477
ALR K + + E+++ K AE LR+K NLL++ELQ
Sbjct: 2183 ALRQK----QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2238
Query: 478 LRAQAALARDMGPPTFPE--DVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEE 535
L+A+A A E V EL +L+A + E + + + + +EE
Sbjct: 2239 LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA--LILRDKDNTQRFLQEE 2296
Query: 536 KEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPL 577
EK+ Q ++ + VA + + + A + LA+ + E +
Sbjct: 2297 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2338
Score = 57.4 bits (137), Expect = 4e-08
Identities = 82/331 (24%), Positives = 140/331 (42%), Gaps = 22/331 (6%)
Query: 262 SIQELEQKLLE-REGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQA 320
SIQE Q+L + E +Q R E E S L EE R R +LE E + G +
Sbjct: 1444 SIQEELQQLRQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1502
Query: 321 SQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRS-------YEREKTSF 373
RA++ Q Q Q+E +LR++++ + + E +L S REK
Sbjct: 1503 QALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1561
Query: 374 GPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRT 433
ALEE + + + E L + +++ ++ A + +A+L+ R +T
Sbjct: 1562 LQALEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE---KT 1616
Query: 434 QDLEGALRTKGLELEVCENELQRK---KNEAELLREKVNLLEQELQELRAQAALARDMGP 490
LE +L+ + + + E +R+ + EAE RE+ E E +L+A AL +
Sbjct: 1617 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELERWQLKANEALRLRLQA 1675
Query: 491 PTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSY 550
+ Q E E+ + E E + + +R + ++E EK Q + Q
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1735
Query: 551 VAMYQRNQRLEKALQQLARGDSAGEPLEVDL 581
+A Q RL +Q G+ + LE +L
Sbjct: 1736 LAAEQELIRLRAETEQ---GEQQRQLLEEEL 1763
Score = 54.7 bits (130), Expect = 2e-07
Identities = 61/252 (24%), Positives = 113/252 (44%), Gaps = 23/252 (9%)
Query: 262 SIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQAS 321
++Q LE+ L+ E A ++L+++ E+ +A E R EL+ K Q
Sbjct: 1561 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL- 1619
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
+R+ Q H+ V QL++E + Q+ + ++ E +L ++ + + +
Sbjct: 1620 ---ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1676
Query: 382 WEVCQKSGEISLLKQQLKESQTEV--NAKASEILGLKAQLKDTRGKLEGLELRTQDLEGA 439
QKS + ++Q +E++ E KA E + +L + + LE + Q EG
Sbjct: 1677 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE-----QELEKQRQLAEGT 1731
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPA 499
+ + E EL R + E E ++ LLE+EL L+ +AA A +
Sbjct: 1732 AQQR----LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--------TQKRQE 1779
Query: 500 LQRELERLRAEL 511
L+ EL ++RAE+
Sbjct: 1780 LEAELAKVRAEM 1791
Score = 53.5 bits (127), Expect = 5e-07
Identities = 73/310 (23%), Positives = 138/310 (44%), Gaps = 28/310 (9%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
+ELE+ L+ AL +L+ EE SLA E ++ ++E E + G +QA ++
Sbjct: 1656 RELERWQLKANEAL-RLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQ 1713
Query: 324 SQRAQQVLHLQV----------LQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSF 373
+ A+Q L Q L +QE +LR E E +++ LLE +L +RE +
Sbjct: 1714 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1773
Query: 374 GPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRT 433
+E + E+ + E+ +L ++ E + + + K +L+ G+ L
Sbjct: 1774 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK---SKQRLEAEAGRFRELAEEA 1830
Query: 434 QDLEGALRTKGLELEVCENELQRKKNEAE-LLREKVNLLEQELQELRAQAAL------AR 486
L + ++ E + R++ EAE +L EK+ + E L+ +A + A
Sbjct: 1831 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKEAE 1889
Query: 487 DMGPPTFPEDVPALQRELERLRAELR---EERQGHDQMSSGFQHERLVWKEEKEKVIQYQ 543
+ ED +R LE A+ + EER + +S + ER K E ++ +
Sbjct: 1890 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER--QKGLVEDTLRQR 1947
Query: 544 KQLQQSYVAM 553
+Q+++ +A+
Sbjct: 1948 RQVEEEILAL 1957
Score = 51.2 bits (121), Expect = 3e-06
Identities = 73/335 (21%), Positives = 141/335 (42%), Gaps = 34/335 (10%)
Query: 267 EQKLLEREGALQKL--QRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKS 324
EQ + +RE A Q+L QR E LA E+ R R E E E + L++ +
Sbjct: 1708 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARL 1766
Query: 325 QRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEV 384
QR + +L+ E ++R E+E L+ + E + RS + A E+
Sbjct: 1767 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1826
Query: 385 CQKSGEISLLKQQLK-------ESQTEVNAKASEILGLK-------------AQLKDTRG 424
+++ + L ++ K E A+A +L K A++
Sbjct: 1827 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1886
Query: 425 KLEGLELRTQDLEGALRTKGLELEVCENELQ--------RKKNEAELLREKVNLLEQELQ 476
+ E LR + A + + LE + +++ RK +++EL R+K L+E L+
Sbjct: 1887 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-GLVEDTLR 1945
Query: 477 ELRA--QAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKE 534
+ R + LA L+ EL R+R+ + + +Q +R + E
Sbjct: 1946 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 2005
Query: 535 EKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLAR 569
E+ + + ++++Q+S A + ++ + AL+++ R
Sbjct: 2006 EERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2040
Score = 50.1 bits (118), Expect = 6e-06
Identities = 63/226 (27%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYE--ERPRRCRDELEGPEPKGGNKLKQAS 321
+E+ +KL E A Q+ + E+ + ER R ELE + K + K
Sbjct: 2438 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2497
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
KS+ Q V Q QL QE + L+Q S + E+D L + R E+EK ++
Sbjct: 2498 LKSEEMQTV---QQEQLLQETQALQQ---SFLSEKDSLLQRERFIEQEKAKLEQLFQD-- 2549
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALR 441
E++ +Q +E Q + E L A +++ R R + E +R
Sbjct: 2550 --------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR-------RQHEAEEGVR 2594
Query: 442 TKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQ--AALA 485
K EL+ E Q+++ + ELL E+ L ++LQ L Q AALA
Sbjct: 2595 RKQEELQQLE---QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2637
Score = 44.3 bits (103), Expect = 3e-04
Identities = 72/340 (21%), Positives = 138/340 (40%), Gaps = 41/340 (12%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLA---------YEERPRRCRDELEGPEPKGG 314
Q + ++L + + L++++R E+ E A YE + + +LE P
Sbjct: 1269 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPA 1327
Query: 315 NKLKQASQKSQRAQQVLHL-----QVLQLQQEKRQLRQELESLMKEQDLLETKLRSYERE 369
K K S Q+ + L ++ L + + E M+E++ L + R+ ERE
Sbjct: 1328 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1387
Query: 370 KTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKAS-EILGLKAQLKDTRGKLEG 428
+ + A E Q +QL E+ + A+A E L+ ++++ + E
Sbjct: 1388 RLAEVEAALEKQ--------------RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1433
Query: 429 LELRTQDLEGALRTKGLEL-EVCENELQRKKNEAELLREKVNLLEQELQELRAQA-ALAR 486
+ Q + +++ + +L + E E+Q K +AE +E+E++ +R Q A R
Sbjct: 1434 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1493
Query: 487 DMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQL 546
G + EL+ LRA E Q + R ++E ++ Q + +L
Sbjct: 1494 QRG---------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1544
Query: 547 QQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADI 586
A + + ++ALQ L E E L A++
Sbjct: 1545 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1584
Score = 37.4 bits (85), Expect = 0.039
Identities = 63/282 (22%), Positives = 113/282 (40%), Gaps = 20/282 (7%)
Query: 324 SQRAQQVLHLQVLQLQQEKRQLR--QELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
S QQ+L Q+E R R EL+ + + + ET+ R PA E Q
Sbjct: 989 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 1048
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGL----------KAQLKDTRGKLEGLEL 431
Q+ + + + L + ++A+A ++L L +++L+ T GKLE +
Sbjct: 1049 RIAEQQKAQAEV--EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1106
Query: 432 RTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPP 491
+ L+T L + + + + E L+E + L EL A A + +
Sbjct: 1107 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE-AQAVPATLPELEATKASLKKLRA- 1164
Query: 492 TFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYV 551
A Q + LR ELR ++ +++ + + +E+V Q ++ Q
Sbjct: 1165 ----QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1220
Query: 552 AMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIA 593
R + LE+ +QL + +PL L+ A E I A
Sbjct: 1221 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1262
Score = 34.3 bits (77), Expect = 0.33
Identities = 47/219 (21%), Positives = 91/219 (41%), Gaps = 25/219 (11%)
Query: 263 IQELEQKLLEREGALQKLQRSF--EEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQA 320
+Q ++Q+ L +E Q LQ+SF E+ L + E+ + ++L E +L++
Sbjct: 2503 MQTVQQEQLLQE--TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2560
Query: 321 SQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEET 380
Q+ Q+ Q++QE+++L +E + Q E +R + E +
Sbjct: 2561 QQRQQQ----------QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2610
Query: 381 QWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLK-AQLKDTRGKLEGLELRTQDLEGA 439
+ + +++ + Q L+E A + E+ + A K + L+ + E
Sbjct: 2611 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2670
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
GL R+K A+ L+E L +ELQ L
Sbjct: 2671 HSFDGL----------RRKVSAQRLQEAGILSAEELQRL 2699
Score = 30.0 bits (66), Expect = 6.3
Identities = 39/157 (24%), Positives = 65/157 (41%), Gaps = 7/157 (4%)
Query: 359 LETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQ 418
LE +++ R+ G E + ++ G S QQL +S + + S ++
Sbjct: 956 LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISE 1015
Query: 419 LKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
LKD R +LE E RT K E + +++K +AE V L + + L
Sbjct: 1016 LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE-----VEGLGKGVARL 1070
Query: 479 RAQAALARDMGPPTFPEDVPALQRELERLRAELREER 515
A+A + P+ P L+ ELE +L + R
Sbjct: 1071 SAEAEKVLALPEPS--PAAPTLRSELELTLGKLEQVR 1105
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 75.9 bits (185), Expect = 1e-13
Identities = 80/357 (22%), Positives = 158/357 (44%), Gaps = 38/357 (10%)
Query: 252 VRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEP 311
++ ++ E +ELE+K++ L K + + + A + + RC D+L +
Sbjct: 865 IKDELAKSEAKRKELEEKMV----TLLKEKNDLQLQVQAEAEGLADAEERC-DQLIKTKI 919
Query: 312 KGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREK- 370
+ K+K+ +++++ +++ +L +KR+L E L K+ D LE L E+EK
Sbjct: 920 QLEAKIKEVTERAEDEEEIN----AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 975
Query: 371 ---------TSFGPALEETQWEVCQKSGEISLLKQQ----LKESQTEVNAKASEILGLKA 417
T L+ET ++ ++ + QQ L+ + +VN + L+
Sbjct: 976 ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ 1035
Query: 418 QLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQE 477
Q+ D G LE + DLE A R +L++ + + +NE + L EK+ E E+
Sbjct: 1036 QVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISN 1095
Query: 478 LRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKE 537
L+++ + +G + + LQ +E L E+ ER + + +R E E
Sbjct: 1096 LQSKIEDEQALG-IQLQKKIKELQARIEELEEEIEAERASRAKA----EKQRSDLSRELE 1150
Query: 538 KVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIAT 594
++ + ++ + A + N++ E Q++ R DLE A + +E AT
Sbjct: 1151 EISERLEEAGGATSAQIEMNKKREAEFQKMRR----------DLEEATLQHEATAAT 1197
Score = 56.2 bits (134), Expect = 8e-08
Identities = 72/325 (22%), Positives = 141/325 (43%), Gaps = 33/325 (10%)
Query: 265 ELEQKLLERE------GALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGN--- 315
E+E +L+ E AL K QR+F+ K LA ++++ ELE + + +
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRNFD-KILAE---WKQKCEETHAELEASQKEARSLGT 1485
Query: 316 ---KLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTS 372
K+K A ++S + L + LQQE L +++ K LE + E+EK
Sbjct: 1486 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545
Query: 373 FGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELR 432
ALEE + + + G+I ++ +L + ++EV+ K +E QLK R + +E
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK--RNHIRIVESM 1603
Query: 433 TQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQE-LQELRAQAALARD---- 487
L+ +R++ + + + +++ NE E+ N + E L+ R + +D
Sbjct: 1604 QSTLDAEIRSRNDAIRL-KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662
Query: 488 -----MGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQY 542
E + ++R L+AE+ E R +Q + R + ++E +
Sbjct: 1663 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQT----ERSRKIAEQELLDASER 1718
Query: 543 QKQLQQSYVAMYQRNQRLEKALQQL 567
+ L ++ ++LE + Q+
Sbjct: 1719 VQLLHTQNTSLINTKKKLETDISQM 1743
Score = 45.8 bits (107), Expect = 1e-04
Identities = 65/316 (20%), Positives = 137/316 (43%), Gaps = 41/316 (12%)
Query: 274 EGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHL 333
+G L+K+ R+ E+ +L+ + EE +R ++L +L+ S + R
Sbjct: 1248 KGNLEKMCRTLED-QLSELKSKEEEQQRLINDLTAQR----GRLQTESGEFSRQLDEKEA 1302
Query: 334 QVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISL 393
V QL + K+ Q++E L ++ LE ++++ K + AL+ ++ + L
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQ---LEEEIKA----KNALAHALQSSRHDC-------DL 1348
Query: 394 LKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLEL-RTQDLEGALRTKGLELEVCEN 452
L++Q +E Q + ++ R K E + RT++LE A + L+ E
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE 1408
Query: 453 ELQRKKNEAELLREKVNLLEQELQEL-----RAQAALARDMGPPTFPEDVPALQRELERL 507
++ + L + L+ E+++L R AA A + QR +++
Sbjct: 1409 HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAA----------LDKKQRNFDKI 1458
Query: 508 RAELREE-RQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKAL-- 564
AE +++ + H ++ + + R + E + Y++ L Q + + N+ L++ +
Sbjct: 1459 LAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ-LETLKRENKNLQQEISD 1517
Query: 565 --QQLARGDSAGEPLE 578
+Q+A G LE
Sbjct: 1518 LTEQIAEGGKRIHELE 1533
Score = 41.6 bits (96), Expect = 0.002
Identities = 63/360 (17%), Positives = 151/360 (41%), Gaps = 53/360 (14%)
Query: 265 ELEQKLLEREGALQKLQRSFEE--KELASSLAYEERPR----RCRDELEGPEPKGGNKLK 318
E+++K+ E++ + +L+R+ + + S+L E R R R + ++EG + +L
Sbjct: 1577 EVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1636
Query: 319 QASQKSQ------------------------RAQQVLHLQVLQLQQEKRQLRQELESL-- 352
A++ + R+Q+ L Q+ +++ L+ E+E L
Sbjct: 1637 HANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA 1696
Query: 353 ----------MKEQDLLET--KLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKE 400
+ EQ+LL+ +++ + TS ++ + ++ Q GE+ + Q+ +
Sbjct: 1697 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARN 1756
Query: 401 SQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCEN-ELQRKKN 459
++ + ++ + +LK + LE +++E ++ L L+ E L+ K
Sbjct: 1757 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1816
Query: 460 EAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHD 519
+ + L +V LE E++ + + A A + + +R ++ L + E+R+
Sbjct: 1817 QIQKLEARVRELEGEVESEQKRNAEA--------VKGLRKHERRVKELTYQTEEDRKNIL 1868
Query: 520 QMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEV 579
++ + K K + + ++Q + + LE+A ++ +S L V
Sbjct: 1869 RLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRV 1928
Score = 33.9 bits (76), Expect = 0.44
Identities = 42/234 (17%), Positives = 90/234 (38%), Gaps = 35/234 (14%)
Query: 253 RSPISTDECSIQ-ELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEP 311
+ + TD +Q E+E L E A +K +++ + + + +E+ LE +
Sbjct: 1733 KKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH--LERMKK 1790
Query: 312 KGGNKLKQASQKSQRAQQVL----HLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYE 367
+K + A+Q+ Q+ +L+ R+L E+ES K LR +E
Sbjct: 1791 NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHE 1850
Query: 368 REKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLE 427
R ++KE + IL L+ + + K++
Sbjct: 1851 R----------------------------RVKELTYQTEEDRKNILRLQDLVDKLQAKVK 1882
Query: 428 GLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQ 481
+ + ++ E T + ++EL+ + A++ +VN L + +E+ +
Sbjct: 1883 SYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTK 1936
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 75.9 bits (185), Expect = 1e-13
Identities = 80/357 (22%), Positives = 158/357 (44%), Gaps = 38/357 (10%)
Query: 252 VRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEP 311
++ ++ E +ELE+K++ L K + + + A + + RC D+L +
Sbjct: 865 IKDELAKSEAKRKELEEKMV----TLLKEKNDLQLQVQAEAEGLADAEERC-DQLIKTKI 919
Query: 312 KGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREK- 370
+ K+K+ +++++ +++ +L +KR+L E L K+ D LE L E+EK
Sbjct: 920 QLEAKIKEVTERAEDEEEIN----AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 975
Query: 371 ---------TSFGPALEETQWEVCQKSGEISLLKQQ----LKESQTEVNAKASEILGLKA 417
T L+ET ++ ++ + QQ L+ + +VN + L+
Sbjct: 976 ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ 1035
Query: 418 QLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQE 477
Q+ D G LE + DLE A R +L++ + + +NE + L EK+ E E+
Sbjct: 1036 QVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISN 1095
Query: 478 LRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKE 537
L+++ + +G + + LQ +E L E+ ER + + +R E E
Sbjct: 1096 LQSKIEDEQALG-IQLQKKIKELQARIEELEEEIEAERASRAKA----EKQRSDLSRELE 1150
Query: 538 KVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIAT 594
++ + ++ + A + N++ E Q++ R DLE A + +E AT
Sbjct: 1151 EISERLEEAGGATSAQIEMNKKREAEFQKMRR----------DLEEATLQHEATAAT 1197
Score = 56.2 bits (134), Expect = 8e-08
Identities = 72/325 (22%), Positives = 141/325 (43%), Gaps = 33/325 (10%)
Query: 265 ELEQKLLERE------GALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGN--- 315
E+E +L+ E AL K QR+F+ K LA ++++ ELE + + +
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRNFD-KILAE---WKQKCEETHAELEASQKEARSLGT 1485
Query: 316 ---KLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTS 372
K+K A ++S + L + LQQE L +++ K LE + E+EK
Sbjct: 1486 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545
Query: 373 FGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELR 432
ALEE + + + G+I ++ +L + ++EV+ K +E QLK R + +E
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK--RNHIRIVESM 1603
Query: 433 TQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQE-LQELRAQAALARD---- 487
L+ +R++ + + + +++ NE E+ N + E L+ R + +D
Sbjct: 1604 QSTLDAEIRSRNDAIRL-KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662
Query: 488 -----MGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQY 542
E + ++R L+AE+ E R +Q + R + ++E +
Sbjct: 1663 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQT----ERSRKIAEQELLDASER 1718
Query: 543 QKQLQQSYVAMYQRNQRLEKALQQL 567
+ L ++ ++LE + Q+
Sbjct: 1719 VQLLHTQNTSLINTKKKLETDISQM 1743
Score = 45.8 bits (107), Expect = 1e-04
Identities = 65/316 (20%), Positives = 137/316 (43%), Gaps = 41/316 (12%)
Query: 274 EGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHL 333
+G L+K+ R+ E+ +L+ + EE +R ++L +L+ S + R
Sbjct: 1248 KGNLEKMCRTLED-QLSELKSKEEEQQRLINDLTAQR----GRLQTESGEFSRQLDEKEA 1302
Query: 334 QVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISL 393
V QL + K+ Q++E L ++ LE ++++ K + AL+ ++ + L
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQ---LEEEIKA----KNALAHALQSSRHDC-------DL 1348
Query: 394 LKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLEL-RTQDLEGALRTKGLELEVCEN 452
L++Q +E Q + ++ R K E + RT++LE A + L+ E
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE 1408
Query: 453 ELQRKKNEAELLREKVNLLEQELQEL-----RAQAALARDMGPPTFPEDVPALQRELERL 507
++ + L + L+ E+++L R AA A + QR +++
Sbjct: 1409 HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAA----------LDKKQRNFDKI 1458
Query: 508 RAELREE-RQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKAL-- 564
AE +++ + H ++ + + R + E + Y++ L Q + + N+ L++ +
Sbjct: 1459 LAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ-LETLKRENKNLQQEISD 1517
Query: 565 --QQLARGDSAGEPLE 578
+Q+A G LE
Sbjct: 1518 LTEQIAEGGKRIHELE 1533
Score = 41.6 bits (96), Expect = 0.002
Identities = 63/360 (17%), Positives = 151/360 (41%), Gaps = 53/360 (14%)
Query: 265 ELEQKLLEREGALQKLQRSFEE--KELASSLAYEERPR----RCRDELEGPEPKGGNKLK 318
E+++K+ E++ + +L+R+ + + S+L E R R R + ++EG + +L
Sbjct: 1577 EVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1636
Query: 319 QASQKSQ------------------------RAQQVLHLQVLQLQQEKRQLRQELESL-- 352
A++ + R+Q+ L Q+ +++ L+ E+E L
Sbjct: 1637 HANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA 1696
Query: 353 ----------MKEQDLLET--KLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKE 400
+ EQ+LL+ +++ + TS ++ + ++ Q GE+ + Q+ +
Sbjct: 1697 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARN 1756
Query: 401 SQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCEN-ELQRKKN 459
++ + ++ + +LK + LE +++E ++ L L+ E L+ K
Sbjct: 1757 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1816
Query: 460 EAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHD 519
+ + L +V LE E++ + + A A + + +R ++ L + E+R+
Sbjct: 1817 QIQKLEARVRELEGEVESEQKRNAEA--------VKGLRKHERRVKELTYQTEEDRKNIL 1868
Query: 520 QMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEV 579
++ + K K + + ++Q + + LE+A ++ +S L V
Sbjct: 1869 RLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRV 1928
Score = 33.9 bits (76), Expect = 0.44
Identities = 42/234 (17%), Positives = 90/234 (38%), Gaps = 35/234 (14%)
Query: 253 RSPISTDECSIQ-ELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEP 311
+ + TD +Q E+E L E A +K +++ + + + +E+ LE +
Sbjct: 1733 KKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH--LERMKK 1790
Query: 312 KGGNKLKQASQKSQRAQQVL----HLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYE 367
+K + A+Q+ Q+ +L+ R+L E+ES K LR +E
Sbjct: 1791 NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHE 1850
Query: 368 REKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLE 427
R ++KE + IL L+ + + K++
Sbjct: 1851 R----------------------------RVKELTYQTEEDRKNILRLQDLVDKLQAKVK 1882
Query: 428 GLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQ 481
+ + ++ E T + ++EL+ + A++ +VN L + +E+ +
Sbjct: 1883 SYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTK 1936
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 73.2 bits (178), Expect = 6e-13
Identities = 92/347 (26%), Positives = 150/347 (43%), Gaps = 29/347 (8%)
Query: 216 GIVLQDSNMMSLKA--LSFSDGGSKLGHSNKADKGPSCVRSPISTDECSIQELEQKLLER 273
G V + +M L+A S D SKL N++ ++ D+ + L +L E
Sbjct: 716 GRVELELSMTKLRAEEASLQDSLSKLSALNES----------LAQDKLDLNRLVAQLEEE 765
Query: 274 EGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHL 333
+ ALQ QR E++ +++A EE+ R LE + G L+ + + +++AQ+ L
Sbjct: 766 KSALQGRQRQAEQE---ATVAREEQERLEELRLEQEVARQG--LEGSLRVAEQAQEALEQ 820
Query: 334 QVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISL 393
Q+ L+ E+ QL+++L L ++ E +L RE ALE E + E +
Sbjct: 821 QLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAG 880
Query: 394 LKQQLKESQTEVNAKASEIL-------GLKAQLKDTRGKLEGLELRTQDLEGALRTKGLE 446
L QL ++ E + E L+ L + + +L LE R + LE + L
Sbjct: 881 LAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLA 940
Query: 447 LEVCENELQRKKNEAELLREKVN----LLEQELQELRAQAALARDMGPPTFPEDVPALQR 502
E EL + + +EK + L+ Q+L + +A + ED+ LQR
Sbjct: 941 KETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQR 1000
Query: 503 ELERLRAELREERQGHDQMSSGFQHERLVWKE-EKEKVIQYQKQLQQ 548
E E EL ER Q E L E EKE++ + LQQ
Sbjct: 1001 EKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ 1047
Score = 55.1 bits (131), Expect = 2e-07
Identities = 74/304 (24%), Positives = 129/304 (42%), Gaps = 47/304 (15%)
Query: 288 ELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK-------SQRAQQVLHLQV--LQL 338
E+AS L+ +E + + EL E + + S+R +Q L L+ L+
Sbjct: 72 EMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELET 131
Query: 339 QQEKRQLRQELE---SLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLK 395
Q+ + +RQ +E L +EQ KL++Y+ + ++ Q ++ Q S L+
Sbjct: 132 QEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELE 191
Query: 396 QQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQ 455
QQL E E+ + +L+DT +QDLE AL + LE +
Sbjct: 192 QQLLERSGELE---------QQRLRDTE--------HSQDLESAL----IRLE------E 224
Query: 456 RKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREER 515
++ A L + L EQ Q A AL+ D+ T D ++ELE A R E
Sbjct: 225 EQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVT--NDWTRCRKELEHREAAWRREE 282
Query: 516 QGHDQMSSGFQHER--LVWKEE---KEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARG 570
+ + S +H R L+W++ + V + + ++ + + R +A+Q+ G
Sbjct: 283 ESFNAYFSN-EHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLG 341
Query: 571 DSAG 574
S G
Sbjct: 342 LSTG 345
Score = 53.9 bits (128), Expect = 4e-07
Identities = 69/332 (20%), Positives = 140/332 (42%), Gaps = 32/332 (9%)
Query: 252 VRSPISTDECSIQELEQKLL----EREGALQK---LQRSFEEKELASSLAYEERPRRCRD 304
+R +S E + LE++L + +GA+Q QR + A+ L E+
Sbjct: 552 LRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHS 611
Query: 305 ELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKR-------QLRQELESLMKEQD 357
+ +L+Q +K Q AQ+ L Q +L++E+ ++R+ELE ++ +
Sbjct: 612 LQVAQQQ--AEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLE 669
Query: 358 LLETKLRSYEREKTSFGPALEET--QWEVCQ-KSGEISLLKQQLKESQTEVNAKASEILG 414
LE K +E AL Q ++ Q + E++ + + + E+ +++
Sbjct: 670 QLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRA 729
Query: 415 LKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQE 474
+A L+D+ KL L + L +LE ++ LQ ++ +AE ++
Sbjct: 730 EEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQER 789
Query: 475 LQELRAQAALAR----------DMGPPTFPEDVPALQRELERLR---AELREERQGHDQM 521
L+ELR + +AR + + +P L+ E +L+ A+L + G +Q
Sbjct: 790 LEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQE 849
Query: 522 SSGFQHERLVWKEEKEKVIQYQKQLQQSYVAM 553
+ E E E+ + ++ L + + +
Sbjct: 850 LEQARREAQRQVEALERAAREKEALAKEHAGL 881
Score = 53.1 bits (126), Expect = 7e-07
Identities = 81/348 (23%), Positives = 138/348 (39%), Gaps = 55/348 (15%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKE--------LASSLAYEERPRRCRDELEGPEPKGGN 315
QELEQ E + ++ L+R+ EKE LA L ER R E
Sbjct: 848 QELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSE-------EAT 900
Query: 316 KLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYER------E 369
+L+ + + + + Q+ QL+ + QL E ++L+ ++ L +L + E
Sbjct: 901 RLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQE 960
Query: 370 KTSFGPALEETQWEVCQKSGEISLLKQQ------LKESQTEVNAKASEILGLKAQL---- 419
K S L + ++ + SL +Q+ L+ Q E A E+ +AQL
Sbjct: 961 KASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQL 1020
Query: 420 -KDTRGKLEGLELRTQDLEGAL------RTKGLELEVCENE--LQRKKNEAELLREKVN- 469
++ L LE ++L + R +GL L E + L K++E L EK+
Sbjct: 1021 QREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMG 1080
Query: 470 --------LLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQM 521
LE E Q+ AQ+ +D V AL EL LRA+ E H Q
Sbjct: 1081 TRHSLATISLEMERQKRDAQSRQEQDRST------VNALTSELRDLRAQREEAAAAHAQE 1134
Query: 522 SSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLAR 569
Q + ++++ ++ ++L+ + L + L + R
Sbjct: 1135 VRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
Score = 52.8 bits (125), Expect = 9e-07
Identities = 59/220 (26%), Positives = 95/220 (43%), Gaps = 22/220 (10%)
Query: 262 SIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQAS 321
S +EL + + E L+ + E+KE LA E R + G G +++++
Sbjct: 1218 SNEELRSAVKKAESERISLKLANEDKE--QKLALLEEARTAVGKEAGELRTGLQEVERSR 1275
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
+++R Q L Q+ L E +L +EL L L E + RE L + +
Sbjct: 1276 LEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGE 1335
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGL--------KAQLKDTRG---KLEG-- 428
+ E+ + +++L+E + E + +LG K QL RG KLE
Sbjct: 1336 ASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAAR 1395
Query: 429 -----LELRTQDLEGALRTKGLELEVCENELQRKKNEAEL 463
L LR EG R +GLE E+ E+QR+ EA+L
Sbjct: 1396 AEAAELGLRLSAAEG--RAQGLEAELARVEVQRRAAEAQL 1433
Score = 50.8 bits (120), Expect = 3e-06
Identities = 101/498 (20%), Positives = 185/498 (37%), Gaps = 60/498 (12%)
Query: 95 GVDFDPSTPPKLMPFSNQLEM---GSEKGAVRPTAFKPVLPRSGAILHSSPESASHQLHP 151
G+ PS P+ +P S + GS +G P+ L SP S P
Sbjct: 1445 GLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPST-----------LECSP--GSQPPSP 1491
Query: 152 APPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPTSRFGGSAH 211
P P +L P GAL R + L S+ + D L T +R
Sbjct: 1492 GPATSPASPDLDPEAVRGAL----REFLQEL----RSAQRERDELRTQTSALNR------ 1537
Query: 212 NITQGIVLQDSNMMSLKALSFSDGGSKLGHSNKADKGPSCVRSPISTDECSIQELEQKLL 271
+ + +DS + L + S+ + D S V++ ++ E S++ E++
Sbjct: 1538 QLAEMEAERDSATSRARQLQKAVAESEEARRS-VDGRLSGVQAELALQEESVRRSERERR 1596
Query: 272 EREGALQKLQRSFE--EKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQ 329
+ L+RS + E EL +S + + +LEG + +LK+ S+
Sbjct: 1597 ATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDK----RRLKEVLDASESRTV 1652
Query: 330 VLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSG 389
L LQ L+ E ++ R L + L+ ++ S +R+ Q V + +G
Sbjct: 1653 KLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNG 1712
Query: 390 EISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEV 449
++ +++ + +V + A L TR K L+ E + L+
Sbjct: 1713 ALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDA 1772
Query: 450 CENELQRKKNEAELLREKVNLLEQELQELRAQAALA-------------RDMGPPTFPED 496
L + ++ L E+V L E+ +L Q A R G
Sbjct: 1773 ARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNT 1832
Query: 497 VPALQRE----------LERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQL 546
V LQ E L+R A+L E++ ++ + + +R+ + +KV + + +
Sbjct: 1833 VQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRS 1892
Query: 547 QQSYVAMYQRNQRLEKAL 564
+ V + RL++ L
Sbjct: 1893 HEDTVRLSAEKGRLDRTL 1910
Score = 47.0 bits (110), Expect = 5e-05
Identities = 75/319 (23%), Positives = 134/319 (42%), Gaps = 33/319 (10%)
Query: 266 LEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRD-ELEGPEPKGGNKLKQASQKS 324
L ++L E E ++ + ++L ++A E RR D L G + + + +++ ++S
Sbjct: 1535 LNRQLAEMEA--ERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQ-EESVRRS 1591
Query: 325 QRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLL---ETKLRSYEREKTSFGPALEE-- 379
+R ++ QV L++ + EL + ++ + ETKL +R A E
Sbjct: 1592 ERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRT 1651
Query: 380 TQWEVCQKSGEISLLKQQLKESQTEVNAKASE--ILGLKAQLKDTRGKLEGLELRTQDLE 437
+ E+ ++S E L + +L S E A+A + + L+ Q+ D+ K L+L + L
Sbjct: 1652 VKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLN 1711
Query: 438 GALRTKGLELEVCENELQRKKNEAE-LLREKVNLLEQELQELRAQAALARD------MGP 490
GAL K E+E LR+KV L + L + A RD
Sbjct: 1712 GALA---------------KVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKAL 1756
Query: 491 PTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSY 550
D LQ L+ R L E R+ + Q R + + + ++ + QLQQ
Sbjct: 1757 TACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLR 1816
Query: 551 VAMYQRNQRLEKALQQLAR 569
+ QR + AL + +
Sbjct: 1817 EVLRQRQEGEAAALNTVQK 1835
Score = 46.2 bits (108), Expect = 8e-05
Identities = 62/271 (22%), Positives = 107/271 (39%), Gaps = 55/271 (20%)
Query: 243 NKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRC 302
++A K S + + T + +LE + +E EG LQ+L+ +
Sbjct: 1778 SEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQ---------------- 1821
Query: 303 RDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETK 362
R E E KL+ + Q L + QL+ EKR++ + L K++ L
Sbjct: 1822 RQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRT 1881
Query: 363 LRSYEREK-------------------TSFGPALE--ETQWEVCQKSGEISLLKQQLKES 401
L EREK T G LE E Q ++ Q ++ +L+Q +
Sbjct: 1882 LDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPA 1941
Query: 402 QTEVNAKASEILGLKAQLKDTRGKLEGLELRTQ-DLEGALRTKGLELEVCENELQRKKNE 460
Q EV+A+ ++ +L+ +L + +T+ LE R + E ++ K +
Sbjct: 1942 QLEVDAQQQQL-----ELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQ 1996
Query: 461 AELLREKVNLLEQELQELRAQAALARDMGPP 491
L+QEL+ R+ A + GPP
Sbjct: 1997 ----------LQQELR--RSSAPFSPPSGPP 2015
Score = 43.9 bits (102), Expect = 4e-04
Identities = 68/284 (23%), Positives = 116/284 (40%), Gaps = 51/284 (17%)
Query: 343 RQLRQELESLMKEQDLLET-------KLRSYEREKTSFGPALEETQWEVCQK-------- 387
R+ QEL S +E+D L T +L E E+ S + Q V +
Sbjct: 1512 REFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVD 1571
Query: 388 ------SGEISLLKQQLKESQTEVNAKASEILGL-------KAQLKDTRGKLEGLELRTQ 434
E++L ++ ++ S+ E A ++ L +++L+ ++ K+ ++
Sbjct: 1572 GRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANET 1631
Query: 435 DLEGALRTKGLELEVCEN-----ELQRKKNEAELLREKVNLLEQELQELRAQAALAR--D 487
LEG R L+ E+ ELQR+ E EL R ++ L ++E Q AQA R
Sbjct: 1632 KLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQ---AQALQDRVDS 1688
Query: 488 MGPPTFPEDVPA--LQRELERLRAELR--EERQG--HDQ---MSSGFQHERLVWKEEKEK 538
+ +V A LQ +ERL L EE +G D+ ++ ++K
Sbjct: 1689 LQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDK 1748
Query: 539 VIQYQKQLQQSYVAMYQRNQRLEKALQQLA----RGDSAGEPLE 578
+ QK L +RL+ A Q L+ + S GE ++
Sbjct: 1749 NLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQ 1792
Score = 42.0 bits (97), Expect = 0.002
Identities = 75/339 (22%), Positives = 135/339 (39%), Gaps = 60/339 (17%)
Query: 264 QELEQKLL-EREGALQKLQRSFEEKELAS-----SLAYEERPRRCRDELEGPEPKGGNKL 317
++L K+L E++ A Q++Q ++ +L++ LA + R + LE +
Sbjct: 369 EQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVK---RLEKQNLEKDQVNKDLTE 425
Query: 318 KQASQKSQRAQQVLHLQVLQ---LQQEKRQLRQ----------ELESLMKEQDLLETKLR 364
K + +S R Q+ L+ LQQ R L Q +L + D LR
Sbjct: 426 KLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLR 485
Query: 365 SYEREKTSFGPALEET---------QWEVCQKSGEISLLKQQLKESQTEVNAKASEILGL 415
++T P C S ++L+ L + Q +V
Sbjct: 486 GLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQV---------- 535
Query: 416 KAQLKDTRGKLEGLELRTQDLEGALRTK----GLELEVCENELQRKKNEAELLREKVNLL 471
+D RG+ E +QDL G LR + E E +LQR +++ + +
Sbjct: 536 ----QDMRGRYEA----SQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDA 587
Query: 472 EQELQELR-AQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERL 530
++E+Q LR A L+R+ V Q E ELR+ER+ + +R
Sbjct: 588 QREVQRLRSANELLSREKSNLAHSLQVAQQQAE------ELRQEREKLQAAQEELRRQRD 641
Query: 531 VWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLAR 569
+EE+E +Q ++++ +++ ++LE LA+
Sbjct: 642 RLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAK 680
Score = 40.4 bits (93), Expect = 0.005
Identities = 63/285 (22%), Positives = 111/285 (38%), Gaps = 64/285 (22%)
Query: 259 DEC--SIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKG--G 314
D C +EL +L E A L+R E + R+ R+ EG E +
Sbjct: 1150 DSCLREAEELRTQLRLLEDARDGLRRELLEAQ-----------RKLRESQEGREVQRQEA 1198
Query: 315 NKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFG 374
+L+++ + + ++ L R+ +EL S +K+ + L+ +K
Sbjct: 1199 GELRRSLGEGAKEREAL-----------RRSNEELRSAVKKAESERISLKLANEDKEQKL 1247
Query: 375 PALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEI---------------------- 412
LEE + V +++GE+ Q+++ S+ E + E+
Sbjct: 1248 ALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQ 1307
Query: 413 ----LGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKV 468
LG +A+ K++R + GL R E +L EL+V + +LQ ++ E R +
Sbjct: 1308 GRLALGERAE-KESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGE---FRTRE 1363
Query: 469 NLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELRE 513
L L+E R D L+ +LE RAE E
Sbjct: 1364 RRLLGSLEEARGTEKQQLD--------HARGLELKLEAARAEAAE 1400
Score = 39.7 bits (91), Expect = 0.008
Identities = 64/271 (23%), Positives = 114/271 (42%), Gaps = 23/271 (8%)
Query: 265 ELEQKLLEREGAL--QKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQ 322
ELEQ+LLER G L Q+L+ + ++L S+L E ++ L +L QA
Sbjct: 189 ELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGS 248
Query: 323 KSQRAQQVLHLQV-------LQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGP 375
+Q + + +L+ + R+E ES ++L R+ F
Sbjct: 249 ANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRR 308
Query: 376 ALEE----TQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLEL 431
+ E T+ ++ Q GE++ + ++E+ ++ GL+ LE L
Sbjct: 309 LVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLST------GLRLAESRAEAALEKQAL 362
Query: 432 RTQDLEGALRTKGL-ELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGP 490
LE LR K L E ++ + ++Q ++A+ L +V L ++ L Q L +D
Sbjct: 363 LQAQLEEQLRDKVLREKDLAQQQMQSDLDKAD-LSARVTELGLAVKRLEKQ-NLEKDQVN 420
Query: 491 PTFPEDVPALQR-ELERLRAELREERQGHDQ 520
E + AL+ L+ A E+ +G Q
Sbjct: 421 KDLTEKLEALESLRLQEQAALETEDGEGLQQ 451
Score = 37.4 bits (85), Expect = 0.039
Identities = 48/201 (23%), Positives = 84/201 (41%), Gaps = 37/201 (18%)
Query: 391 ISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVC 450
+ L++QL +S++E A L+ QL+ R K +G +D
Sbjct: 549 LGTLRKQLSDSESERRA-------LEEQLQRLRDKTDGAMQAHED--------------A 587
Query: 451 ENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAE 510
+ E+QR ++ ELL + + L LQ + QA R E + A Q EL R R
Sbjct: 588 QREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQE-----REKLQAAQEELRRQRDR 642
Query: 511 LREERQGHDQMSSGFQ--------HERLVWKEEKEKVIQYQ-KQLQQSYVAMYQRNQRLE 561
L EE++ D + G + H +L E K V+ + +++++ + L+
Sbjct: 643 LEEEQE--DAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ 700
Query: 562 KALQQLARGDSAGEPLEVDLE 582
++A + E V+LE
Sbjct: 701 AEKAEVAEALTKAEAGRVELE 721
>gi|239745114 PREDICTED: Golgin subfamily A member 8-like protein 3
[Homo sapiens]
Length = 580
Score = 72.8 bits (177), Expect = 8e-13
Identities = 71/319 (22%), Positives = 152/319 (47%), Gaps = 46/319 (14%)
Query: 258 TDECSIQELEQKLLEREGALQKLQRSFEEKELASSL-AYEERPRRCRDELEGPEPKGGNK 316
T ++++LE ER L RS E +L +++ + +++ ++ +LE +
Sbjct: 67 TSSATLKDLESPCQERAVVLDS--RSVEISQLKNTIKSLKQQKKQVEHQLE--------E 116
Query: 317 LKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPA 376
K+A+ K Q+A++VL +Q+ L +K +L +L + + LR +E +
Sbjct: 117 EKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRS-------LRYFEEKSKDLAVR 169
Query: 377 LEETQWEVCQKSGEI-SLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQD 435
L+ + Q+ GE+ S+L + + + N ++ + + L+G R Q
Sbjct: 170 LQHS----LQRKGELESVLSNVMATQKKKANQFKESFQQVQLERDEYSEHLKGERARWQQ 225
Query: 436 LEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPE 495
R + + E+C + +++++ +V LE+ L +L+ Q A PP P
Sbjct: 226 -----RMRKMSQEICTLKKEKQQD-----MRRVEKLERSLSKLKNQMAEPLPPEPPAVPS 275
Query: 496 DVPA--LQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAM 553
+V L++ELER+ EL+ + + + ++S Q + +E++E++ + ++++Q+ +
Sbjct: 276 EVELQHLRKELERVAGELQAQVKNNQRISLLNQRQEERIREQEERLRKQEERIQEQH--- 332
Query: 554 YQRNQRLEKALQQLARGDS 572
K+LQQLA+ S
Sbjct: 333 --------KSLQQLAKPQS 343
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 72.0 bits (175), Expect = 1e-12
Identities = 83/356 (23%), Positives = 157/356 (44%), Gaps = 38/356 (10%)
Query: 253 RSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPK 312
+ ++ E +ELE+K++ LQ + + A SLA E RC D+L + +
Sbjct: 864 KEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAE--ADSLADAEE--RC-DQLIKTKIQ 918
Query: 313 GGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREK-- 370
K+K+ +++++ +++ +L +KR+L E L K+ D LE L E+EK
Sbjct: 919 LEAKIKEVTERAEDEEEIN----AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 974
Query: 371 --------TSFGPALEETQWEVCQKSGEISLLKQQ----LKESQTEVNAKASEILGLKAQ 418
T L+ET ++ ++ + QQ L+ + +VN + L+ Q
Sbjct: 975 TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQ 1034
Query: 419 LKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478
+ D G LE + DLE A R +L++ + +N+ + L EK+ E E+ L
Sbjct: 1035 VDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGL 1094
Query: 479 RAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEK 538
+++ + +G + + LQ +E L E+ ER + + +R E E+
Sbjct: 1095 QSKIEDEQALG-MQLQKKIKELQARIEELEEEIEAERASRAKA----EKQRSDLSRELEE 1149
Query: 539 VIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIAT 594
+ + ++ + A + N++ E Q++ R DLE A + +E AT
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRR----------DLEEATLQHEATAAT 1195
Score = 57.0 bits (136), Expect = 5e-08
Identities = 68/308 (22%), Positives = 136/308 (44%), Gaps = 27/308 (8%)
Query: 276 ALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGN------KLKQASQKSQRAQQ 329
AL K QR+F+ K LA ++++ ELE + + + K+K A ++S +
Sbjct: 1445 ALDKKQRNFD-KILAE---WKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLE 1500
Query: 330 VLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSG 389
L + LQQE L +++ K LE + E+EK+ ALEE + + + G
Sbjct: 1501 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEG 1560
Query: 390 EISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEV 449
+I ++ +L + ++EV+ K +E Q+K R + +E L+ +R++ + +
Sbjct: 1561 KILRIQLELNQVKSEVDRKIAEKDEEIDQMK--RNHIRIVESMQSTLDAEIRSRNDAIRL 1618
Query: 450 CENELQRKKNEAELLREKVNLLEQE-LQELRAQAALARD---------MGPPTFPEDVPA 499
+ +++ NE E+ N + E L+ R A+ +D E +
Sbjct: 1619 -KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAM 1677
Query: 500 LQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQR 559
++R L+AE+ E R +Q + R + ++E + + L ++ ++
Sbjct: 1678 VERRANLLQAEIEELRATLEQT----ERSRKIAEQELLDASERVQLLHTQNTSLINTKKK 1733
Query: 560 LEKALQQL 567
LE + Q+
Sbjct: 1734 LETDISQI 1741
Score = 53.5 bits (127), Expect = 5e-07
Identities = 67/341 (19%), Positives = 142/341 (41%), Gaps = 54/341 (15%)
Query: 250 SCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERP---RRCRDEL 306
S ++S I ++ +L++K+ E + +++L+ E + + + A ++R R +
Sbjct: 1092 SGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS 1151
Query: 307 EGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSY 366
E E GG Q +R + E +++R++LE + + LR
Sbjct: 1152 ERLEEAGGATSAQIEMNKKR------------EAEFQKMRRDLEEATLQHEATAATLRKK 1199
Query: 367 EREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKL 426
+ + E+ ++ + +KQ+L++ ++E+ + ++ + +G L
Sbjct: 1200 HADSVA----------ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNL 1249
Query: 427 EGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALAR 486
E + +D ++TK E E QR N+ R + L+ E E Q +
Sbjct: 1250 EKMCRALEDQLSEIKTK-------EEEQQRLINDLTAQRAR---LQTESGEYSRQLD-EK 1298
Query: 487 DMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHE-------RLVWKEEKEKV 539
D A +++E L+ +L EE + ++ Q R ++EE+E
Sbjct: 1299 DTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAK 1358
Query: 540 IQYQKQLQQ--SYVAMY---------QRNQRLEKALQQLAR 569
+ Q+ + + S VA + QR + LE+A ++LA+
Sbjct: 1359 AELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1399
Score = 44.7 bits (104), Expect = 2e-04
Identities = 68/322 (21%), Positives = 142/322 (44%), Gaps = 31/322 (9%)
Query: 274 EGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHL 333
+G L+K+ R+ E+ +L+ EE +R ++L + L+ S + R
Sbjct: 1246 KGNLEKMCRALED-QLSEIKTKEEEQQRLINDLTAQRAR----LQTESGEYSRQLDEKDT 1300
Query: 334 QVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISL 393
V QL + K+ Q++E L ++ LE ++++ K++ AL+ ++ + L
Sbjct: 1301 LVSQLSRGKQAFTQQIEELKRQ---LEEEIKA----KSALAHALQSSRHDC-------DL 1346
Query: 394 LKQQLKESQTEVNAKASEILG-LKAQLKDTRGKLEGLEL-RTQDLEGALRTKGLELEVCE 451
L++Q +E Q E A+ + +++ R K E + RT++LE A + L+ E
Sbjct: 1347 LREQYEEEQ-EAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1405
Query: 452 NELQRKKNEAELLREKVNLLEQELQEL-----RAQAALAR-DMGPPTFPEDVPALQRELE 505
++ + L + L+ E+++L R AA A D F + + +++ E
Sbjct: 1406 EHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCE 1465
Query: 506 RLRAELREERQGHDQMSSGFQHERLVWKE---EKEKVIQYQKQLQQSYVAMYQRNQRLEK 562
AEL ++ +S+ + ++E + E + + K LQQ + ++ K
Sbjct: 1466 ETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1525
Query: 563 ALQQLARGDSAGEPLEVDLEGA 584
+ +L + E + +L+ A
Sbjct: 1526 RIHELEKIKKQVEQEKSELQAA 1547
Score = 38.9 bits (89), Expect = 0.014
Identities = 55/281 (19%), Positives = 120/281 (42%), Gaps = 56/281 (19%)
Query: 326 RAQQVLHLQVLQLQQEKRQLRQELESL------------MKEQDLLET--KLRSYEREKT 371
R+Q+ L Q+ +++ L+ E+E L + EQ+LL+ +++ + T
Sbjct: 1666 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1725
Query: 372 SFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLEL 431
S ++ + ++ Q GE+ + Q+ + ++ + ++ + +LK
Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELK----------- 1774
Query: 432 RTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPP 491
+ QD L LE +LQ + +EAE L K ++++Q+L A+
Sbjct: 1775 KEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG--KKQIQKLEARV--------- 1823
Query: 492 TFPEDVPALQRELERLRAELREERQGHDQMSSGF-QHERLV------WKEEKEKVIQYQK 544
RELE E+ E++ + + G +HER V +E+++ +++ Q
Sbjct: 1824 ----------RELE---GEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQD 1870
Query: 545 QLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGAD 585
+ + + ++ E+A +Q S ++ +LE A+
Sbjct: 1871 LVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAE 1911
Score = 35.4 bits (80), Expect = 0.15
Identities = 38/197 (19%), Positives = 84/197 (42%), Gaps = 16/197 (8%)
Query: 253 RSPISTDECSIQ-ELEQKLLEREGALQKLQRSFEEKELASSLAYEERP-----RRCRDEL 306
+ + TD IQ E+E + E A +K +++ + + + +E+ R + L
Sbjct: 1731 KKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1790
Query: 307 EGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSY 366
E ++L +A Q + + + Q+ +L+ R+L E+ES K LR +
Sbjct: 1791 EQTVKDLQHRLDEAEQLALKGGKK---QIQKLEARVRELEGEVESEQKRNVEAVKGLRKH 1847
Query: 367 EREKTSFGPALEETQWEVC-------QKSGEISLLKQQLKESQTEVNAKASEILGLKAQL 419
ER+ EE + + + ++ K+Q +E++ + N S+ ++ +L
Sbjct: 1848 ERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHEL 1907
Query: 420 KDTRGKLEGLELRTQDL 436
++ + + E + L
Sbjct: 1908 EEAEERADIAESQVNKL 1924
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 72.0 bits (175), Expect = 1e-12
Identities = 90/348 (25%), Positives = 158/348 (45%), Gaps = 32/348 (9%)
Query: 265 ELEQKLLEREGALQKLQRSFEE--KELASSLAYEERPR----RCRDELEGPEPKGGNKLK 318
E+++KL E++ L+R+ + + L +SL E R R R + ++EG +L
Sbjct: 1620 EVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLG 1679
Query: 319 QASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALE 378
A++++ AQ L QL++E+ R E + L E L + ++ ER + LE
Sbjct: 1680 HATRQATEAQAATRLMQAQLKEEQAG-RDEEQRLAAE---LHEQAQALERRASLLAAELE 1735
Query: 379 ETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGL-------KAQLKDTRGKLEGLEL 431
E + + Q L +Q+L E+ +N S+ GL +A L G++E
Sbjct: 1736 ELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQ 1795
Query: 432 RTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPP 491
++ E + + + EL+++++ + L LEQ ++EL+A+ A
Sbjct: 1796 ERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALR 1855
Query: 492 TFPEDVPALQRELERLRAELREERQGHDQMSSGF-QHERLVWK-----EEKEKVIQYQKQ 545
+ V L+ ++ L AEL E++ H + G +HER V + EE K + +
Sbjct: 1856 GGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQD 1915
Query: 546 L---QQSYVAMYQRNQRLEKALQQ----LARGDSAGEPLEVDLEGADI 586
L QS V Y+R + E+A QQ LA+ A L+ E AD+
Sbjct: 1916 LVDKLQSKVKSYKR--QFEEAEQQANTNLAKYRKAQHELDDAEERADM 1961
Score = 56.6 bits (135), Expect = 6e-08
Identities = 76/329 (23%), Positives = 143/329 (43%), Gaps = 40/329 (12%)
Query: 272 EREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQVL 331
+RE L +L+R EE L R+ + +G +L + QR +Q L
Sbjct: 1215 KREAELGRLRRELEEAALRHEATVAALRRK--------QAEGAAELGEQVDSLQRVRQKL 1266
Query: 332 HLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEI 391
+ +L+ E L +E+L + + E R+YE + + +EE Q ++ S +
Sbjct: 1267 EKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQ- 1325
Query: 392 SLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCE 451
+ +L+ E++ E L +QL +RGK + ++L L +
Sbjct: 1326 ---RGRLQTESGELSRLLEEKECLISQL--SRGKALAAQ-SLEELRRQLEEESKAKSALA 1379
Query: 452 NELQRKKNEAELLREKVNLLEQELQELRAQAALAR-------DMGPPTFPEDVPALQR-- 502
+ +Q +++ +LLRE Q +E AQA L R ++ + A+QR
Sbjct: 1380 HAVQALRHDCDLLRE------QHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTE 1433
Query: 503 ELE----RLRAELREERQGHDQMS---SGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQ 555
ELE +L L+E +G + + S + +L + E E V ++ + A+ +
Sbjct: 1434 ELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDK 1493
Query: 556 RNQRLEKALQQLARGDSAGEPLEVDLEGA 584
+ + LE+AL++ R + E ++ +LE A
Sbjct: 1494 KQRHLERALEERRRQE---EEMQRELEAA 1519
Score = 52.8 bits (125), Expect = 9e-07
Identities = 79/322 (24%), Positives = 138/322 (42%), Gaps = 53/322 (16%)
Query: 276 ALQKLQRSFEEKELASSLAYEERPRRCRD---ELEGPEPKGGN------KLKQASQKSQR 326
AL K QR E A EER R+ + ELE + + +L+ +++
Sbjct: 1490 ALDKKQRHLER-------ALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALE 1542
Query: 327 AQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQ 386
A + L + LQ+E L ++ K LE ++ E EK+ ALEE + +
Sbjct: 1543 ALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALEL 1602
Query: 387 KSGEISLLKQQLKESQTEVNAKASE---------------ILGLKAQL-KDTRGKLEGLE 430
+ + ++ +L + + EV+ K +E + L+A L +TR + E L
Sbjct: 1603 EETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALR 1662
Query: 431 LRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRA----QAALAR 486
L+ + +EG L +LE+ R+ EA+ L++ +L+E +A + LA
Sbjct: 1663 LK-KKMEGDLN----DLELQLGHATRQATEAQ---AATRLMQAQLKEEQAGRDEEQRLAA 1714
Query: 487 DMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQL 546
++ E AL+R L AEL E R +Q G + RL ++E + + L
Sbjct: 1715 EL-----HEQAQALERRASLLAAELEELRAALEQ---GERSRRLA-EQELLEATERLNLL 1765
Query: 547 QQSYVAMYQRNQRLEKALQQLA 568
+ + ++LE L QL+
Sbjct: 1766 HSQNTGLLNQKKKLEADLAQLS 1787
Score = 52.4 bits (124), Expect = 1e-06
Identities = 79/336 (23%), Positives = 141/336 (41%), Gaps = 46/336 (13%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKEL---------------ASSLAYE-ERPRRCRDELE 307
Q+LE+KL +++ L +L E+++L A L E E R R +E
Sbjct: 1123 QQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVE 1182
Query: 308 GPEPKGGNKLKQASQKSQRAQQVLHLQ---VLQLQQEKRQLRQELESLMKEQDLLETKLR 364
+ +L++ S++ + A Q + + E +LR+ELE + LR
Sbjct: 1183 KQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALR 1242
Query: 365 SYERE-KTSFGPALEETQWEVCQKSGEISLLKQQLK------ESQTEVNAKASEIL-GLK 416
+ E G ++ Q + E S L+ ++ E+ T A A ++ +
Sbjct: 1243 RKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYE 1302
Query: 417 AQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVN----LLE 472
QL + + K+E L+ + D T+ L+ EL R E E L +++ L
Sbjct: 1303 DQLSEAKIKVEELQRQLADAS----TQRGRLQTESGELSRLLEEKECLISQLSRGKALAA 1358
Query: 473 QELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVW 532
Q L+ELR Q V AL+ + + LR + EE + ++ +RL+
Sbjct: 1359 QSLEELRRQLE-EESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAEL------QRLLS 1411
Query: 533 KEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLA 568
K E V Q++ + + + QR + LE+A ++LA
Sbjct: 1412 KANAE-VAQWRSKYEADAI---QRTEELEEAKKKLA 1443
Score = 44.3 bits (103), Expect = 3e-04
Identities = 76/326 (23%), Positives = 126/326 (38%), Gaps = 71/326 (21%)
Query: 260 ECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQ 319
EC I +L + +L++L+R EE E K + L
Sbjct: 1344 ECLISQLSRGKALAAQSLEELRRQLEE-----------------------ESKAKSALAH 1380
Query: 320 ASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRS-YEREKTSFGPALE 378
A Q + +L Q +E+ + + EL+ L+ + + + RS YE + A++
Sbjct: 1381 AVQALRHDCDLLREQ----HEEEAEAQAELQRLLSKANAEVAQWRSKYEAD------AIQ 1430
Query: 379 ETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEG 438
T+ E+ + +++L Q+ +E NAK S LE +LR Q
Sbjct: 1431 RTE-ELEEAKKKLALRLQEAEEGVEAANAKCS--------------SLEKAKLRLQ---- 1471
Query: 439 ALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVP 498
E E EL+R + A L +K LE+ L+E R Q ++
Sbjct: 1472 ------TESEDVTLELERATSAAAALDKKQRHLERALEERRRQ--------EEEMQRELE 1517
Query: 499 ALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQ 558
A QRE L EL R GH++ + + K +E++ Q+ S ++ Q
Sbjct: 1518 AAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSI----Q 1573
Query: 559 RLEKALQQLARGDSAGEPLEVDLEGA 584
LEK + L S + + EGA
Sbjct: 1574 ELEKTKKALEGEKSEIQAALEEAEGA 1599
Score = 43.9 bits (102), Expect = 4e-04
Identities = 71/324 (21%), Positives = 133/324 (41%), Gaps = 35/324 (10%)
Query: 217 IVLQDSNMMSLKALSFSDGGSKLGHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGA 276
++ Q S +L A S + +L +KA + + D ++E ++ E +
Sbjct: 1346 LISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAE 1405
Query: 277 LQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVL 336
LQ+L + YE + +ELE + K +L++A + + A + +
Sbjct: 1406 LQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAA----NAKCS 1461
Query: 337 QLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQ 396
L++ K +L+ E E + E + + + ++++ ALEE ++
Sbjct: 1462 SLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEER--------------RR 1507
Query: 397 QLKESQTEVNAKASEILGLKAQLKDTR-GKLEGLELRTQDLEGALRTKGLELEVCENELQ 455
Q +E Q E+ A E GL +L R G E LE AL T E + + E+
Sbjct: 1508 QEEEMQRELEAAQRESRGLGTELFRLRHGHEEALE--------ALETLKRENKNLQEEIS 1559
Query: 456 RKKNEAELLREKVNLLEQ-----ELQELRAQAALARDMGPPTFPE-DVPALQRELERLRA 509
++ L + + LE+ E ++ QAAL G E +Q EL +++A
Sbjct: 1560 DLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKA 1619
Query: 510 ELREERQGHDQMSSGFQ--HERLV 531
E+ + D+ + + H+R V
Sbjct: 1620 EVDRKLAEKDEECANLRRNHQRAV 1643
Score = 41.6 bits (96), Expect = 0.002
Identities = 66/319 (20%), Positives = 135/319 (42%), Gaps = 44/319 (13%)
Query: 279 KLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQL 338
K+Q + KEL+ L EE E+ KL+ + ++ L L + +
Sbjct: 961 KVQLEGKVKELSERLEDEE-------EVNADLAARRRKLEDECTELKKDIDDLKLTLAKA 1013
Query: 339 QQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLL---K 395
++EK+ ++++L +E L+ + +EK + A ++ ++ + +S L K
Sbjct: 1014 EKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAK 1073
Query: 396 QQLKESQTEVNAKASEILGLKAQLKDTRGKLEG-LELRTQDLEGALRTKGLELEVCENEL 454
+L++ ++ + L+ + + KLEG L+L + + A + K + E +L
Sbjct: 1074 LRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDK----QQLEEKL 1129
Query: 455 QRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREE 514
++K +E L +V ++ Q L AQ + + LQ E L EL E
Sbjct: 1130 KKKDSELSQLSLRV----EDEQLLGAQ-----------MQKKIKELQARAEELEEELEAE 1174
Query: 515 RQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAG 574
R ++ + +R E E++ ++L+++ A + + K +L R
Sbjct: 1175 RAARARV----EKQRAEAARELEEL---SERLEEAGGASAGQREGCRKREAELGR----- 1222
Query: 575 EPLEVDLEGADIPYEDIIA 593
L +LE A + +E +A
Sbjct: 1223 --LRRELEEAALRHEATVA 1239
Score = 36.2 bits (82), Expect = 0.088
Identities = 36/189 (19%), Positives = 80/189 (42%), Gaps = 15/189 (7%)
Query: 265 ELEQKLLEREGALQKLQRSFEEKELASSLAYEERP-----RRCRDELEGPEPKGGNKLKQ 319
E+E+ ER A +K +++ + + + +E+ R + LE + +L++
Sbjct: 1789 EVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEE 1848
Query: 320 ASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEE 379
A Q + R + QV +L+ + R+L EL++ K+ +R +ER EE
Sbjct: 1849 AEQAALRGGKK---QVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEE 1905
Query: 380 TQWEVCQK-------SGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELR 432
+ + + ++ K+Q +E++ + N ++ + +L D + + E +
Sbjct: 1906 DRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQ 1965
Query: 433 TQDLEGALR 441
L R
Sbjct: 1966 ANKLRARTR 1974
>gi|239745147 PREDICTED: similar to Golgin subfamily A member 8-like
protein 1 isoform 1 [Homo sapiens]
Length = 630
Score = 71.6 bits (174), Expect = 2e-12
Identities = 78/341 (22%), Positives = 155/341 (45%), Gaps = 55/341 (16%)
Query: 258 TDECSIQELEQKLLEREGALQKLQRSFEEKELASSL-AYEERPRRCRDELEGPEPKGGNK 316
T ++++LE ER L RS E +L +++ + +++ ++ +LE +
Sbjct: 67 TSSATLKDLESPCQERAVVLDS--RSVEISQLKNTIKSLKQQKKQVEHQLE--------E 116
Query: 317 LKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPA 376
K+A+ K Q+A++VL +Q+ L +K +L +L + + LR +E +
Sbjct: 117 EKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRS-------LRYFEEKSKDLAVR 169
Query: 377 LEETQWEVCQKSGEIS------LLKQQLKESQTEVNAKAS----------EILGLKAQLK 420
L+ + Q+ GE+ + Q+ K +Q +KA E LK QL
Sbjct: 170 LQHS----LQRKGELESVLSNVMATQKKKANQLSSRSKARTEWKLEQSMREEALLKVQLT 225
Query: 421 DTRGKLEGLELR----TQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQ 476
+ + ++L ++ L+G + E+ K E + +V LE+ L
Sbjct: 226 QLKESFQQVQLERDEYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLS 285
Query: 477 ELRAQAALARDMGPPTFPEDVPA--LQRELERLRAELREERQGHDQMSSGFQHERLVWKE 534
+L+ Q A PP P +V L++ELER+ EL+ + + + ++S Q + +E
Sbjct: 286 KLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVKKNQRISLLNQRQEERIQE 345
Query: 535 EKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGE 575
++E++ + ++++Q+ + K+LQQLA+ S E
Sbjct: 346 QEERLRKQEERIQEQH-----------KSLQQLAKPQSVFE 375
Score = 43.5 bits (101), Expect = 6e-04
Identities = 49/230 (21%), Positives = 102/230 (44%), Gaps = 21/230 (9%)
Query: 349 LESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAK 408
L+S E L+ ++S +++K LEE + +K +L+ Q++ +
Sbjct: 86 LDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEEL 145
Query: 409 ASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKV 468
+++ +K L+ K + L +R L+ +L+ KG V N + +K +A L +
Sbjct: 146 NTDLYHMKRSLRYFEEKSKDLAVR---LQHSLQRKGELESVLSNVMATQKKKANQLSSRS 202
Query: 469 NL-LEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQH 527
E +L++ + AL L+ +L +L+ ++ + D+ S +
Sbjct: 203 KARTEWKLEQSMREEAL---------------LKVQLTQLKESFQQVQLERDEYSEHLKG 247
Query: 528 ERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPL 577
ER W++ K+ Q L++ +R ++LE++L +L + EPL
Sbjct: 248 ERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLK--NQMAEPL 295
>gi|239745111 PREDICTED: Golgin subfamily A member 8-like protein 3
isoform 1 [Homo sapiens]
Length = 632
Score = 71.6 bits (174), Expect = 2e-12
Identities = 77/338 (22%), Positives = 154/338 (45%), Gaps = 55/338 (16%)
Query: 258 TDECSIQELEQKLLEREGALQKLQRSFEEKELASSL-AYEERPRRCRDELEGPEPKGGNK 316
T ++++LE ER L RS E +L +++ + +++ ++ +LE +
Sbjct: 67 TSSATLKDLESPCQERAVVLDS--RSVEISQLKNTIKSLKQQKKQVEHQLE--------E 116
Query: 317 LKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPA 376
K+A+ K Q+A++VL +Q+ L +K +L +L + + LR +E +
Sbjct: 117 EKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRS-------LRYFEEKSKDLAVR 169
Query: 377 LEETQWEVCQKSGEIS------LLKQQLKESQTEVNAKAS----------EILGLKAQLK 420
L+ + Q+ GE+ + Q+ K +Q +KA E LK QL
Sbjct: 170 LQHS----LQRKGELESVLSNVMATQKKKANQLSSRSKARTEWKLEQSMREEALLKVQLT 225
Query: 421 DTRGKLEGLELR----TQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQ 476
+ + ++L ++ L+G + E+ K E + +V LE+ L
Sbjct: 226 QFKESFQQVQLERDEYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLS 285
Query: 477 ELRAQAALARDMGPPTFPEDVPA--LQRELERLRAELREERQGHDQMSSGFQHERLVWKE 534
+L+ Q A PP P +V L++ELER+ EL+ + + + ++S Q + +E
Sbjct: 286 KLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVKNNQRISLLNQRQEERIRE 345
Query: 535 EKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDS 572
++E++ + ++++Q+ + K+LQQLA+ S
Sbjct: 346 QEERLRKQEERIQEQH-----------KSLQQLAKPQS 372
>gi|239745099 PREDICTED: similar to Golgin subfamily A member 8-like
protein 1 isoform 1 [Homo sapiens]
Length = 632
Score = 71.6 bits (174), Expect = 2e-12
Identities = 78/341 (22%), Positives = 155/341 (45%), Gaps = 55/341 (16%)
Query: 258 TDECSIQELEQKLLEREGALQKLQRSFEEKELASSL-AYEERPRRCRDELEGPEPKGGNK 316
T ++++LE ER L RS E +L +++ + +++ ++ +LE +
Sbjct: 67 TSSATLKDLESPCQERAVVLDS--RSVEISQLKNTIKSLKQQKKQVEHQLE--------E 116
Query: 317 LKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPA 376
K+A+ K Q+A++VL +Q+ L +K +L +L + + LR +E +
Sbjct: 117 EKKANNKKQKAKRVLEVQLQTLNIQKEELNTDLYHMKRS-------LRYFEEKSKDLAVR 169
Query: 377 LEETQWEVCQKSGEIS------LLKQQLKESQTEVNAKAS----------EILGLKAQLK 420
L+ + Q+ GE+ + Q+ K +Q +KA E LK QL
Sbjct: 170 LQHS----LQRKGELESVLSDVMATQKKKANQLSSPSKAGTEWKLEQSMREEALLKVQLT 225
Query: 421 DTRGKLEGLELR----TQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQ 476
+ + ++L ++ L+G + E+ K E + +V LE+ L
Sbjct: 226 QLKESFQQVQLERDEYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLS 285
Query: 477 ELRAQAALARDMGPPTFPEDVPA--LQRELERLRAELREERQGHDQMSSGFQHERLVWKE 534
+L+ Q A PP P +V L++ELER+ EL+ + + + ++S Q + +E
Sbjct: 286 KLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVKNNQRISLLNQRQEERIRE 345
Query: 535 EKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGE 575
++E++ + ++++Q+ + K+LQQLA+ S E
Sbjct: 346 QEERLRKQEERIQEQH-----------KSLQQLAKPQSVFE 375
Score = 42.4 bits (98), Expect = 0.001
Identities = 46/212 (21%), Positives = 93/212 (43%), Gaps = 13/212 (6%)
Query: 377 LEETQWEVCQKSGEISLLKQQLKESQTEV-------NAKASEILGLKAQLKDTRGKLEGL 429
L+ E+ Q I LKQQ K+ + ++ N K L+ QL+ + E L
Sbjct: 86 LDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQLQTLNIQKEEL 145
Query: 430 ELRTQDLEGALR---TKGLELEV-CENELQRKKNEAELLREKVNLLEQELQELRAQAALA 485
++ +LR K +L V ++ LQRK +L + + +++ +L + +
Sbjct: 146 NTDLYHMKRSLRYFEEKSKDLAVRLQHSLQRKGELESVLSDVMATQKKKANQLSSPSKAG 205
Query: 486 RDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQ 545
+ + L+ +L +L+ ++ + D+ S + ER W++ K+ Q
Sbjct: 206 TEWKLEQSMREEALLKVQLTQLKESFQQVQLERDEYSEHLKGERARWQQRMRKMSQEICT 265
Query: 546 LQQSYVAMYQRNQRLEKALQQLARGDSAGEPL 577
L++ +R ++LE++L +L + EPL
Sbjct: 266 LKKEKQQDMRRVEKLERSLSKLK--NQMAEPL 295
>gi|239745130 PREDICTED: similar to Golgin subfamily A member 8-like
protein 1 isoform 1 [Homo sapiens]
Length = 632
Score = 70.5 bits (171), Expect = 4e-12
Identities = 78/341 (22%), Positives = 154/341 (45%), Gaps = 55/341 (16%)
Query: 258 TDECSIQELEQKLLEREGALQKLQRSFEEKELASSL-AYEERPRRCRDELEGPEPKGGNK 316
T ++++LE ER L RS E +L +++ + +++ ++ +LE +
Sbjct: 67 TSSATLKDLESPCQERAVVLDS--RSVEISQLKNTIKSLKQQKKQVEHQLE--------E 116
Query: 317 LKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPA 376
K+A+ K Q+A++VL +Q+ L +K +L +L + + LR +E +
Sbjct: 117 EKKANNKKQKAKRVLEVQIQTLNIQKGKLNTDLYHMKRS-------LRYFEEKSKDLAVC 169
Query: 377 LEETQWEVCQKSGEIS------LLKQQLKESQTEVNAKAS----------EILGLKAQLK 420
L+ + Q+ GE+ + Q+ K +Q +KA E LK QL
Sbjct: 170 LQHS----LQRKGELESVLSNVMATQKKKANQLSSRSKARTEWKLEQSMREEALLKVQLT 225
Query: 421 DTRGKLEGLELRTQD----LEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQ 476
+ + ++L + L+G + E+ K E + +V LE+ L
Sbjct: 226 QLKESFQQVQLERDECAEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLS 285
Query: 477 ELRAQAALARDMGPPTFPEDVPA--LQRELERLRAELREERQGHDQMSSGFQHERLVWKE 534
+L+ Q A PP P +V L++ELER+ EL+ + + + ++S Q + +E
Sbjct: 286 KLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVKKNQRISLLNQRQEERIQE 345
Query: 535 EKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGE 575
++E++ + ++++Q+ + K+LQQLA+ S E
Sbjct: 346 QEERLRKQEERIQEQH-----------KSLQQLAKPQSVFE 375
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 70.1 bits (170), Expect = 5e-12
Identities = 76/328 (23%), Positives = 141/328 (42%), Gaps = 37/328 (11%)
Query: 259 DECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLK 318
+E S E E L+R+G + + S + L + E+ ELE + +L
Sbjct: 997 EELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELT 1056
Query: 319 QASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALE 378
+A QK + + L +L+ RQL++ + L K Q LE K + + L
Sbjct: 1057 EALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIK----DLTAELR 1112
Query: 379 ETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEG 438
E + E+ K E+ + Q LKE E+ +A+++ L +++ RG++E ++ LEG
Sbjct: 1113 ECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIK---LEG 1169
Query: 439 ALRTKGLELEVCENELQ----RKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFP 494
L LEL+ C +++ + +N E LREK ++ Q QE
Sbjct: 1170 TLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQE----------------- 1212
Query: 495 EDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMY 554
+ L++E+ER + ++E M S + + + ++ I ++L+ + +
Sbjct: 1213 --ISQLKKEIERTQQRMKE-------MESVMKEQEQYIATQYKEAIDLGQELRLTREQVQ 1263
Query: 555 QRNQRLEKALQQLARGDSAGEPLEVDLE 582
+ L +A Q + E L +LE
Sbjct: 1264 NSHTELAEARHQQVQAQREIERLSSELE 1291
Score = 66.2 bits (160), Expect = 8e-11
Identities = 70/307 (22%), Positives = 132/307 (42%), Gaps = 47/307 (15%)
Query: 234 DGGSKLGHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSL 293
DG +K H ++ D ++ + +++ELE+ E L + + E E
Sbjct: 1012 DGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQN 1071
Query: 294 AYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLM 353
A+ E R E L+ QK+Q + + + + L E R+ + E+E
Sbjct: 1072 AHGELKSTLRQLQE---------LRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIED-- 1120
Query: 354 KEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEIL 413
K+Q+LLE AL+E WE+ Q++ +++ L ++E + E+ K ++
Sbjct: 1121 KKQELLE------------MDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLE 1168
Query: 414 GL----KAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVN 469
G + +LK+ ++E L + Q+ + LR K + E E+ + K E E ++++
Sbjct: 1169 GTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMK 1228
Query: 470 LLEQELQE--------------LRAQAALARDMGPPTFPEDVPA------LQRELERLRA 509
+E ++E L + L R+ + E A QRE+ERL +
Sbjct: 1229 EMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSS 1288
Query: 510 ELREERQ 516
EL + +Q
Sbjct: 1289 ELEDMKQ 1295
Score = 55.8 bits (133), Expect = 1e-07
Identities = 61/255 (23%), Positives = 118/255 (46%), Gaps = 42/255 (16%)
Query: 260 ECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQ 319
E + ++ L E E L++ Q+ EKE + + EE + D LE + K G + ++
Sbjct: 297 EAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLE--QTKQGKRAER 354
Query: 320 ASQKSQRAQQVLHLQVLQ--LQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPAL 377
QR + + + + L QQ K+++ ++LE + E+++LE L + E+E
Sbjct: 355 -----QRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKEN------- 402
Query: 378 EETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLE 437
+ Q E+ +LK++L++ LK + + + KL + ++ ++
Sbjct: 403 KRLQERCGLYKSELEILKEKLRQ--------------LKEENNNGKEKLRIMAVKNSEVM 448
Query: 438 GALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDV 497
L + E+EL+ N+ E+LR+K +L+ E +EL+ + A E +
Sbjct: 449 AQLTESRQSILKLESELE---NKDEILRDKFSLM-NENRELKVRVAAQN--------ERL 496
Query: 498 PALQRELERLRAELR 512
Q+E+E R ELR
Sbjct: 497 DLCQQEIESSRVELR 511
Score = 55.1 bits (131), Expect = 2e-07
Identities = 71/345 (20%), Positives = 140/345 (40%), Gaps = 72/345 (20%)
Query: 242 SNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRR 301
SNK D+ C + ++ I EL KL +E +QKL + +L+ SL
Sbjct: 542 SNKEDRCIGCCEA----NKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLI------T 591
Query: 302 CRDELEG---------PEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESL 352
C D E P GG+++ ++ + + H Q ++E+++L +E L
Sbjct: 592 CNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQ-----HTMNKQYEKERQRLVTGIEEL 646
Query: 353 MKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKES-------QTEV 405
TKL E E + + + + ++ + L++++L E ++E+
Sbjct: 647 -------RTKLIQIEAENS-------DLKVNMAHRTSQFQLIQEELLEKASNSSKLESEM 692
Query: 406 NAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLR 465
K S++L L+ QL++ + + +LE L K
Sbjct: 693 TKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKN--------------------- 731
Query: 466 EKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQ---GHDQMS 522
EK+ LE + + LA + E +++++ERL A+L ++ Q ++
Sbjct: 732 EKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTM 791
Query: 523 SGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQL 567
S Q + + + E + + L +S M + N + ++AL+ L
Sbjct: 792 SMLQQDIICKQHHLESL---DRLLTESKGEMKKENMKKDEALKAL 833
Score = 54.3 bits (129), Expect = 3e-07
Identities = 70/331 (21%), Positives = 145/331 (43%), Gaps = 36/331 (10%)
Query: 265 ELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKS 324
ELEQ+L+E+ ++ L+ + + LA+E+ K Q
Sbjct: 722 ELEQELMEKNEKIRSLETNINTEHEKICLAFEKA-----------------KKIHLEQHK 764
Query: 325 QRAQQVLHLQVLQLQQEKRQLRQELESL-MKEQDLL--ETKLRSYEREKTSFGPALEETQ 381
+ +Q+ L+ QL+++ +Q +++ +++ M +QD++ + L S +R T + E +
Sbjct: 765 EMEKQIERLEA-QLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTE---SKGEMK 820
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALR 441
E +K + L+ Q+ E +V S + K +L +LEG + E L+
Sbjct: 821 KENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEG---NKEKFEKQLK 877
Query: 442 TKGLELEVCENELQRKKNEAELLREKVNLLE---QELQELRAQAALARDMGPPT---FPE 495
K E+ + EL+ K + + E+ +L+ Q+ Q++ Q + T +
Sbjct: 878 KKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEK 937
Query: 496 DVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQ 555
V L++EL++ R E+ + ++ HE + +++KVI+ +Q + M Q
Sbjct: 938 QVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADL---KRQKVIELTGTARQVKIEMDQ 994
Query: 556 RNQRLEKALQQLARGDSAGEPLEVDLEGADI 586
+ L K +++ GE + L D+
Sbjct: 995 YKEELSKMEKEIMHLKRDGENKAMHLSQLDM 1025
Score = 54.3 bits (129), Expect = 3e-07
Identities = 74/329 (22%), Positives = 145/329 (44%), Gaps = 28/329 (8%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEER--PRRCRDELEGPEPKGGNKLKQAS 321
+E+E+++ E L+K + F+E+E S+ ++ + + L+ + ++K+ +
Sbjct: 764 KEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKEN 823
Query: 322 QKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQ 381
K A + L QV + + RQL LE + KE+ +L L E K F L++
Sbjct: 824 MKKDEALKALQNQVSEETIKVRQLDSALE-ICKEELVLH--LNQLEGNKEKFEKQLKK-- 878
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALR 441
KS E+ L+++LK + + + + L+ L+ + L+ +R +LE
Sbjct: 879 -----KSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQT 933
Query: 442 TKGLELEVCENELQR-KKNEAELLREKVNLLEQELQE--LRAQAALARDMGPPTFPEDVP 498
++ E ELQ+ +++ AE LR+ E E L+ Q + ++
Sbjct: 934 KLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMD 993
Query: 499 ALQRELERLRAELRE-ERQGHDQMSSGFQHERLV--WKEEKEKVIQYQKQLQQSYVAMYQ 555
+ EL ++ E+ +R G ++ Q + ++ K E EK K+L++ +
Sbjct: 994 QYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEK---LQHS 1050
Query: 556 RNQRLEKALQQLARGDSAGEPLEVDLEGA 584
L +ALQ+ E LE +L+ A
Sbjct: 1051 TETELTEALQK-------REVLETELQNA 1072
Score = 40.0 bits (92), Expect = 0.006
Identities = 50/229 (21%), Positives = 97/229 (42%), Gaps = 51/229 (22%)
Query: 334 QVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISL 393
++ L+++ +LRQ+ L+ + L TK S E T + + Q++ + +
Sbjct: 230 EIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLE-SAQQQAASVPI 288
Query: 394 LKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENE 453
L++Q+ + EV+A+ L++ KLE ++Q + V E E
Sbjct: 289 LEEQIINLEAEVSAQDKV-------LREAENKLE----QSQKM------------VIEKE 325
Query: 454 LQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELRE 513
++++ E ++ KV+LLEQ Q RA ER R E
Sbjct: 326 QSLQESKEECIKLKVDLLEQTKQGKRA------------------------ERQR---NE 358
Query: 514 ERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEK 562
+++S FQ + E+ EKV ++ L+++ + N+RL++
Sbjct: 359 ALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQE 407
>gi|195947367 golgi autoantigen, golgin subfamily a, 8B [Homo
sapiens]
Length = 603
Score = 68.6 bits (166), Expect = 2e-11
Identities = 79/362 (21%), Positives = 159/362 (43%), Gaps = 42/362 (11%)
Query: 240 GHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSL-AYEER 298
G S + C S S+ S Q + + A+ RS + L ++ + +++
Sbjct: 40 GSSPETAASGGCHSSEASSSASSSLHARQSPCQEQAAVLN-SRSIKISRLNDTIKSLKQQ 98
Query: 299 PRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDL 358
++ +LE + K+A+ + Q+A++ L Q+ +L EK++L +L +
Sbjct: 99 KKQVEHQLE--------EEKKANNEKQKAERELEGQIQRLNTEKKKLNTDLYHMKHSLRY 150
Query: 359 LETKLRSYEREKTSFGPALEETQWEVCQ------------KSGEISLLKQQLKESQTEVN 406
E + + + E +W +C S +LLK+QL++S E
Sbjct: 151 FEEESKDLAGRLQRSSQRIGELEWSLCAVAATQKKKPDGFSSRSKALLKRQLEQSIREQI 210
Query: 407 AKASEILGLKAQLKDTRGKLE--GLELRTQDLEGALRTKGLELEVCENELQRKKNEAELL 464
+ LK LK+ + + + +++ + + R + + EVC + ++K +
Sbjct: 211 LLKGHVTQLKESLKEVQLERDQYAEQIKGERAQWQQRMRKMSQEVCTLKEEKKHD----- 265
Query: 465 REKVNLLEQELQELRAQAALARDMGPPTFPEDVPA--LQRELERLRAELREERQGHDQMS 522
+V LE+ L L+ Q A P +V L++ELER+ EL+ + + + +S
Sbjct: 266 THRVEELERSLSRLKNQMAEPLPPDAPAVSSEVELQDLRKELERVAGELQAQVENNQCIS 325
Query: 523 SGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLE 582
L+ + +KE++ + +++LQ+ + +R EK LQQLA S E L+ + +
Sbjct: 326 -------LLNRGQKERLREQEERLQEQQERLRER----EKRLQQLAEPQSDLEELKHENK 374
Query: 583 GA 584
A
Sbjct: 375 SA 376
>gi|31083099 golgi autoantigen, golgin subfamily a, 8A [Homo
sapiens]
Length = 603
Score = 68.6 bits (166), Expect = 2e-11
Identities = 79/362 (21%), Positives = 159/362 (43%), Gaps = 42/362 (11%)
Query: 240 GHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSL-AYEER 298
G S + C S S+ S Q + + A+ RS + L ++ + +++
Sbjct: 40 GSSPETAASGGCHSSEASSSASSSLHARQSPCQEQAAVLN-SRSIKISRLNDTIKSLKQQ 98
Query: 299 PRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDL 358
++ +LE + K+A+ + Q+A++ L Q+ +L EK++L +L +
Sbjct: 99 KKQVEHQLE--------EEKKANNEKQKAERELEGQIQRLNTEKKKLNTDLYHMKHSLRY 150
Query: 359 LETKLRSYEREKTSFGPALEETQWEVCQ------------KSGEISLLKQQLKESQTEVN 406
E + + + E +W +C S +LLK+QL++S E
Sbjct: 151 FEEESKDLAGRLQRSSQRIGELEWSLCAVAATQKKKPDGFSSRSKALLKRQLEQSIREQI 210
Query: 407 AKASEILGLKAQLKDTRGKLE--GLELRTQDLEGALRTKGLELEVCENELQRKKNEAELL 464
+ LK LK+ + + + +++ + + R + + EVC + ++K +
Sbjct: 211 LLKGHVTQLKESLKEVQLERDQYAEQIKGERAQWQQRMRKMSQEVCTLKEEKKHD----- 265
Query: 465 REKVNLLEQELQELRAQAALARDMGPPTFPEDVPA--LQRELERLRAELREERQGHDQMS 522
+V LE+ L L+ Q A P +V L++ELER+ EL+ + + + +S
Sbjct: 266 THRVEELERSLSRLKNQMAEPLPPDAPAVSSEVELQDLRKELERVAGELQAQVENNQCIS 325
Query: 523 SGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLE 582
L+ + +KE++ + +++LQ+ + +R EK LQQLA S E L+ + +
Sbjct: 326 -------LLNRGQKERLREQEERLQEQQERLRER----EKRLQQLAEPQSDLEELKHENK 374
Query: 583 GA 584
A
Sbjct: 375 SA 376
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 68.6 bits (166), Expect = 2e-11
Identities = 79/315 (25%), Positives = 142/315 (45%), Gaps = 45/315 (14%)
Query: 263 IQELEQKLLEREGALQKLQRSFE-EKELASSLAYE-ERPRRCRDELEGPEP--KGGNKLK 318
++ EQ+ ERE Q+ +R E EK+L E +R R E+E E + + +
Sbjct: 386 LERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQR 445
Query: 319 QASQKSQRAQQVLHLQ------VLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTS 372
Q + R Q++L+ + ++ L+ +K+ L ELE+L ++ LE KL+ T+
Sbjct: 446 QLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTT 505
Query: 373 FGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTR-GKLEGLEL 431
+E T + EI+ L+QQL+ESQ + E L QLK + L L
Sbjct: 506 QRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSL 565
Query: 432 RTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPP 491
T L+ AL K L + ++L + E +++++ +L+ELR
Sbjct: 566 VT--LKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELR------------ 611
Query: 492 TFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYV 551
E+ ++Q Q S + ERL KE++ K+I+ +KQ +++
Sbjct: 612 ------------------EIHNKQQLQKQKS--MEAERLKQKEQERKIIELEKQKEEAQR 651
Query: 552 AMYQRNQRLEKALQQ 566
+R+++ + +QQ
Sbjct: 652 RAQERDKQWLEHVQQ 666
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 68.6 bits (166), Expect = 2e-11
Identities = 79/315 (25%), Positives = 142/315 (45%), Gaps = 45/315 (14%)
Query: 263 IQELEQKLLEREGALQKLQRSFE-EKELASSLAYE-ERPRRCRDELEGPEP--KGGNKLK 318
++ EQ+ ERE Q+ +R E EK+L E +R R E+E E + + +
Sbjct: 386 LERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQR 445
Query: 319 QASQKSQRAQQVLHLQ------VLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTS 372
Q + R Q++L+ + ++ L+ +K+ L ELE+L ++ LE KL+ T+
Sbjct: 446 QLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTT 505
Query: 373 FGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTR-GKLEGLEL 431
+E T + EI+ L+QQL+ESQ + E L QLK + L L
Sbjct: 506 QRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSL 565
Query: 432 RTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPP 491
T L+ AL K L + ++L + E +++++ +L+ELR
Sbjct: 566 VT--LKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELR------------ 611
Query: 492 TFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYV 551
E+ ++Q Q S + ERL KE++ K+I+ +KQ +++
Sbjct: 612 ------------------EIHNKQQLQKQKS--MEAERLKQKEQERKIIELEKQKEEAQR 651
Query: 552 AMYQRNQRLEKALQQ 566
+R+++ + +QQ
Sbjct: 652 RAQERDKQWLEHVQQ 666
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 68.2 bits (165), Expect = 2e-11
Identities = 69/315 (21%), Positives = 148/315 (46%), Gaps = 32/315 (10%)
Query: 260 ECSIQELEQKLLEREGAL-QKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLK 318
E I+ELE+K+ E+E Q+ +R EEK E+ + R E + E + K++
Sbjct: 376 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE--EKIR 433
Query: 319 QASQKSQRAQQVLHLQVLQLQQEKRQLRQEL----ESLMKEQDLLETKLRSYEREKTSFG 374
+ +K R ++ +H Q ++EKRQ ++E+ E + +++++ K + +E+EK
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIR-- 491
Query: 375 PALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQ 434
EE W +K + +++++E + ++ + +I + ++++ K+ E Q
Sbjct: 492 -KQEEKVWRQEEKMHD---QEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQ 547
Query: 435 DLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFP 494
+ E + E + K E E +R + + ++ +++R Q R+ +
Sbjct: 548 EQEEKM-----------GEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWE 596
Query: 495 EDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEK-----EKVIQYQKQLQQS 549
++ RE E + E +EE+ + Q E++ +EEK EK+ + + +L+Q
Sbjct: 597 QEEKI--REQEEMMQE-QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 653
Query: 550 YVAMYQRNQRLEKAL 564
M + + LE A+
Sbjct: 654 EEKMQEHQEHLEAAI 668
Score = 55.8 bits (133), Expect = 1e-07
Identities = 66/320 (20%), Positives = 146/320 (45%), Gaps = 28/320 (8%)
Query: 256 ISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKG-- 313
I E I+E E+K+ E+E +++ + EK EE+ RR + + E K
Sbjct: 316 IQEQEEKIREQEEKIREQEEKMRRQEEMMWEK--------EEKMRRQEEMMWEKEEKMRR 367
Query: 314 -GNKLKQASQKSQRAQQVLHLQ-VLQLQQEKRQLRQELESLMKEQDLLETKLRSYE--RE 369
+ + +K + ++ +H Q ++ Q+EKRQ +++ K Q+ R E RE
Sbjct: 368 LEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 427
Query: 370 KTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGL 429
+ E+ W +K E ++++ K + E + E + + ++ + K+
Sbjct: 428 QEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQ 487
Query: 430 ELRTQDLEGALRTK----GLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALA 485
E + E R + E ++ E E + + E ++ ++ + EQE +++R Q +
Sbjct: 488 EKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQE-EKIREQEEMM 546
Query: 486 RD----MGPPTFPEDVPALQRELERLRAELRE-ERQGHDQMSSGFQHERLVWKEEKEKVI 540
++ MG E+ Q ++ R ++RE E + +Q + E +W E++EK+
Sbjct: 547 QEQEEKMGE---QEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIW-EQEEKIR 602
Query: 541 QYQKQLQQSYVAMYQRNQRL 560
+ ++ +Q+ M+++ +++
Sbjct: 603 EQEEMMQEQEEKMWEQEEKM 622
Score = 47.8 bits (112), Expect = 3e-05
Identities = 66/330 (20%), Positives = 137/330 (41%), Gaps = 52/330 (15%)
Query: 267 EQKLLEREGALQKLQRSFEEKELASSLAYEERPRRC--------RDELEGPEPKGGNKLK 318
+++L E+ LQ+ + E ++ L +E R+ + +L+ G +L+
Sbjct: 216 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 275
Query: 319 QASQKSQRAQQVLHL-QVLQLQQEKRQLRQE-----LESLMKEQDLLETKLRSYE---RE 369
S K Q + L L QQE++ RQE E ++EQ E K+R E RE
Sbjct: 276 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQ---EEKIREQEEKIRE 332
Query: 370 KTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGL 429
+ EE WE +++++ + + K ++ L+ + + K+ L
Sbjct: 333 QEEKMRRQEEMMWE----------KEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIREL 382
Query: 430 ELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMG 489
E + + E E + K+ E E +RE+ EQE + R + +
Sbjct: 383 EEKMHEQEKI------------REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 430
Query: 490 PPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERL-----VWKE-----EKEKV 539
E Q E + ++REE + +Q Q E++ +W++ E+EK+
Sbjct: 431 KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKI 490
Query: 540 IQYQKQLQQSYVAMYQRNQRLEKALQQLAR 569
+ ++++ + M+ + +++ + +++ R
Sbjct: 491 RKQEEKVWRQEEKMHDQEEKIREQEEKMWR 520
Score = 46.6 bits (109), Expect = 7e-05
Identities = 53/244 (21%), Positives = 115/244 (47%), Gaps = 25/244 (10%)
Query: 339 QQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQL 398
+ E++ Q E+L +E + +R +KT AL +Q V Q GE L +L
Sbjct: 108 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 167
Query: 399 KESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENEL--QR 456
+S + + Q K +E L T++ + L LE+ N + +
Sbjct: 168 HDSWKFAGELEQALSAVATQKKKADRYIEEL---TKERD------ALSLELYRNTITDEE 218
Query: 457 KKNEAELLREKVNLLEQE-------LQELRAQAALARDMGP-PTFPEDVPALQRELERLR 508
K + L+EK+ L+E E ++EL+ + A+ + P + L +EL+ +
Sbjct: 219 LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVS 278
Query: 509 AELR---EERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQ 565
A+L+ EE + ++++ Q E +W++E EK+ ++++++Q+ + ++ +++ + +
Sbjct: 279 AKLQAQVEENELWNRLNQ--QQEEKMWRQE-EKIQEWEEKIQEQEEKIREQEEKIREQEE 335
Query: 566 QLAR 569
++ R
Sbjct: 336 KMRR 339
Score = 43.9 bits (102), Expect = 4e-04
Identities = 57/307 (18%), Positives = 139/307 (45%), Gaps = 28/307 (9%)
Query: 265 ELEQKLLEREGALQKLQRSFEE--KELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQ 322
ELEQ L +K R EE KE +L+ E DE +LK+ +
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKE-RDALSLELYRNTITDE----------ELKEKNA 224
Query: 323 KSQRAQQVLHLQVLQLQQEKRQLRQELES---LMKEQDLLETKLRSYEREKTSFGPALEE 379
K Q Q++ + ++Q ++L+++LE L+ +Q L + E G L+
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQL--------QAEADHLGKELQS 276
Query: 380 TQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGA 439
++ + E L + ++ + ++ + +I + ++++ K+ E + ++ E
Sbjct: 277 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEK 336
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPA 499
+R + + E +++R++ EK+ LE+ + E + R++ ++
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEK---IRELEEKMHEQEKIR 393
Query: 500 LQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQR 559
Q E + ++RE+ + +Q + ++ E + +E++EK+ + +K++ + ++++ +
Sbjct: 394 EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI-REQEEKIREQEKKMWRQEEKIHEQEKI 452
Query: 560 LEKALQQ 566
E+ +Q
Sbjct: 453 REEEKRQ 459
Score = 31.2 bits (69), Expect = 2.8
Identities = 23/100 (23%), Positives = 49/100 (49%), Gaps = 19/100 (19%)
Query: 253 RSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPK 312
+ I E I E E+K+ E+E +Q+ EEK +E+ + C E
Sbjct: 584 KEKIREQEEKIWEQEEKIREQEEMMQEQ----EEK------MWEQEEKMCEQE------- 626
Query: 313 GGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESL 352
K+++ +K +R ++ + Q ++L+Q++ ++++ E L
Sbjct: 627 --EKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 68.2 bits (165), Expect = 2e-11
Identities = 87/365 (23%), Positives = 160/365 (43%), Gaps = 58/365 (15%)
Query: 253 RSPISTDECSIQELEQK---LLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGP 309
+ ++ E +ELE+K LL+ + LQ LQ E LA + E+ + + +LE
Sbjct: 863 KDELAKSEAKRKELEEKMVTLLKEKNDLQ-LQVQSEADSLADAEERCEQLIKNKIQLEA- 920
Query: 310 EPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYERE 369
K+K+ +++++ +++ +L +KR+L E L K+ D LE L E+E
Sbjct: 921 ------KIKEVTERAEEEEEIN----AELTAKKRKLEDECSELKKDIDDLELTLAKVEKE 970
Query: 370 K----------TSFGPALEETQWEVCQKSGEISLLKQQ----LKESQTEVNAKASEILGL 415
K T L+ET ++ ++ + QQ L+ + +VN L
Sbjct: 971 KHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKL 1030
Query: 416 KAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQEL 475
+ Q+ D G LE + DLE A R +L++ + +N+ + L EK+ E E+
Sbjct: 1031 EQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEI 1090
Query: 476 QELRAQAALARDMGPPTFPEDVPA----LQRELERLRA---ELREERQGHDQMSSGFQHE 528
L ++ ED A LQ++++ L+A EL EE + + + +
Sbjct: 1091 SNLISKI------------EDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQ 1138
Query: 529 RLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPY 588
R E E++ + ++ + A + N++ E Q+L R DLE A + +
Sbjct: 1139 RSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRR----------DLEEATLQH 1188
Query: 589 EDIIA 593
E ++A
Sbjct: 1189 EAMVA 1193
Score = 57.0 bits (136), Expect = 5e-08
Identities = 74/325 (22%), Positives = 138/325 (42%), Gaps = 33/325 (10%)
Query: 265 ELEQKLLERE------GALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGN--- 315
E+E +L+ E AL K QR+F++ YEE + ELE + + +
Sbjct: 1427 EVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEET----QAELEASQKESRSLST 1482
Query: 316 ---KLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTS 372
K+K ++S + L + LQQE L +++ K+ LE + E+EK
Sbjct: 1483 ELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCE 1542
Query: 373 FGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELR 432
ALEE + + + G+I ++ +L + ++EV+ K +E QLK R +E
Sbjct: 1543 IQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK--RNHTRVVETM 1600
Query: 433 TQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQE-LQELRAQAALARD---- 487
L+ +R++ L V + +++ NE E+ N L E L+ R + ++
Sbjct: 1601 QSTLDAEIRSRNDALRV-KKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLH 1659
Query: 488 -----MGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQY 542
G E + ++R L+AE+ E +Q + R + ++E +
Sbjct: 1660 LDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQT----ERSRKIAEQELLDASER 1715
Query: 543 QKQLQQSYVAMYQRNQRLEKALQQL 567
+ L ++ ++LE + QL
Sbjct: 1716 VQLLHTQNTSLINTKKKLENDVSQL 1740
Score = 53.5 bits (127), Expect = 5e-07
Identities = 68/333 (20%), Positives = 145/333 (43%), Gaps = 55/333 (16%)
Query: 259 DECSIQ-ELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKL 317
DE +++ +L++K+ E + +++L E + + + A ++R R+ L
Sbjct: 1099 DEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRE------------L 1146
Query: 318 KQASQKSQRAQQVLHLQV---LQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFG 374
++ S++ + A QV + + E ++LR++LE + + + LR + +
Sbjct: 1147 EEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMA-- 1204
Query: 375 PALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQ 434
E+ ++ + +KQ+L++ ++E+ + ++ + +G LE + +
Sbjct: 1205 --------ELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLE 1256
Query: 435 DLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFP 494
D L+TK E E QR N+ R + L+ E E Q +D
Sbjct: 1257 DQVSELKTK-------EEEQQRLINDLTAQRAR---LQTEAGEYSRQLD-EKDALVSQLS 1305
Query: 495 EDVPALQRELERLRAELREERQGHDQMSSGFQHE-------RLVWKEEKEKVIQYQKQLQ 547
A +++E L+ +L EE + + ++ Q R ++EE+E + Q+ L
Sbjct: 1306 RSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS 1365
Query: 548 Q--SYVAMY---------QRNQRLEKALQQLAR 569
+ S VA + QR + LE+A ++LA+
Sbjct: 1366 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1398
Score = 46.2 bits (108), Expect = 8e-05
Identities = 72/367 (19%), Positives = 153/367 (41%), Gaps = 35/367 (9%)
Query: 231 SFSDGGSKLGHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELA 290
S ++ G ++ + + + +S + + + + + + +G L+K+ RS E++
Sbjct: 1202 SMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSE 1261
Query: 291 SSLAYEERPRRCRD---ELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQ 347
EE+ R D + + + G +Q +K V QL + K+ Q
Sbjct: 1262 LKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDAL--------VSQLSRSKQASTQ 1313
Query: 348 ELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNA 407
++E L K Q ETK K + AL+ ++ + LL++Q +E Q
Sbjct: 1314 QIEEL-KHQLEEETKA------KNALAHALQSSRHDC-------DLLREQYEEEQEGKAE 1359
Query: 408 KASEILGLKAQLKDTRGKLEGLEL-RTQDLEGALRTKGLELEVCENELQRKKNEAELLRE 466
+ +++ R K E + RT++LE A + L+ E ++ + L +
Sbjct: 1360 LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEK 1419
Query: 467 KVNLLEQELQEL-----RAQAALAR-DMGPPTFPEDVPALQRELERLRAELREERQGHDQ 520
L+ E+++L R+ AA A D F + + +++ E +AEL ++
Sbjct: 1420 TKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRS 1479
Query: 521 MSSGFQHERLVWKE---EKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPL 577
+S+ + V++E + E + + K LQQ + ++ K + +L + E
Sbjct: 1480 LSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQE 1539
Query: 578 EVDLEGA 584
+ +++ A
Sbjct: 1540 KCEIQAA 1546
Score = 41.6 bits (96), Expect = 0.002
Identities = 70/360 (19%), Positives = 144/360 (40%), Gaps = 62/360 (17%)
Query: 268 QKLLEREGALQKLQRS----------------FEEKELASSLAYEERPRRCRDELEGPEP 311
QK+L+R AL +Q + F+ K L S E+ ++E +
Sbjct: 805 QKMLQRREALFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQ---- 860
Query: 312 KGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELES--------------LMKEQD 357
K K KS+ ++ L +++ L +EK L+ +++S L+K +
Sbjct: 861 ----KTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKI 916
Query: 358 LLETKLRSYEREKTSFGPALEETQWEVCQK----SGEISLLKQQLKESQTEVNAKASEIL 413
LE K+ +E T EE E+ K E S LK+ + + + + E
Sbjct: 917 QLEAKI----KEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 972
Query: 414 GLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQ 473
+ ++K+ ++ GL+ L + + ++LQ ++++ +L + LEQ
Sbjct: 973 ATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQ 1032
Query: 474 ELQELRAQAALARDMGPPTFPEDVPALQRELE-------RLRAELREERQGHDQM--SSG 524
++ +L + + D+ +R+LE ++ ++Q D+
Sbjct: 1033 QVDDLEGSLEQEKKL-----RMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKE 1087
Query: 525 FQHERLVWKEEKEKV--IQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLE 582
F+ L+ K E E+ IQ QK++++ + + + +E A+ + L +LE
Sbjct: 1088 FEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELE 1147
Score = 35.4 bits (80), Expect = 0.15
Identities = 38/197 (19%), Positives = 84/197 (42%), Gaps = 16/197 (8%)
Query: 253 RSPISTDECSIQ-ELEQKLLEREGALQKLQRSFEEKELASSLAYEERP-----RRCRDEL 306
+ + D +Q E+E+ + E A +K +++ + + + +E+ R + L
Sbjct: 1730 KKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1789
Query: 307 EGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSY 366
E ++L +A Q + + + Q+ +L+ R+L E+E+ K LR +
Sbjct: 1790 EQTVKDLQHRLDEAEQLALKGGKK---QIQKLEARVRELEGEVENEQKRNAEAVKGLRKH 1846
Query: 367 EREKTSFGPALEETQWEVC-------QKSGEISLLKQQLKESQTEVNAKASEILGLKAQL 419
ER EE + V + ++ K+Q +E++ + NA S+ L+ +L
Sbjct: 1847 ERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHEL 1906
Query: 420 KDTRGKLEGLELRTQDL 436
++ + + E + L
Sbjct: 1907 EEAEERADIAESQVNKL 1923
Score = 33.5 bits (75), Expect = 0.57
Identities = 44/227 (19%), Positives = 91/227 (40%), Gaps = 13/227 (5%)
Query: 256 ISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGN 315
+ T S+ ++KL E + +LQ EE S A E+ + D E
Sbjct: 1719 LHTQNTSLINTKKKL---ENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEEL--K 1773
Query: 316 KLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQ-ELESLMKEQDLLETKLRSYEREKTSFG 374
K + S +R ++ L V LQ + Q L+ K+ LE ++R E E
Sbjct: 1774 KEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGE----- 1828
Query: 375 PALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQ 434
+E Q + + ++++KE + +L L+ + + K++ + + +
Sbjct: 1829 --VENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAE 1886
Query: 435 DLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQ 481
+ E + ++EL+ + A++ +VN L + +E+ +
Sbjct: 1887 EAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTK 1933
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 67.8 bits (164), Expect = 3e-11
Identities = 71/318 (22%), Positives = 138/318 (43%), Gaps = 51/318 (16%)
Query: 267 EQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQR 326
E+ + E + ++LQ+ FE+K L E++ +R + G L+ S++SQR
Sbjct: 1376 ERAVREVDFTKKRLQQEFEDK-----LEVEQQNKRQLERRLGD-------LQADSEESQR 1423
Query: 327 AQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQ 386
A Q L + +L E + + LE LE K R ++ E + A EE Q E Q
Sbjct: 1424 ALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQ---AHEEAQREKLQ 1480
Query: 387 KS----------GEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDL 436
+ E LKQQL+E ++ +++ L+A+L+D + E +
Sbjct: 1481 REKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKV 1540
Query: 437 EGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPED 496
+ LR +++ E EL + ++L + LE E++ +R + + E
Sbjct: 1541 KKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEA 1600
Query: 497 VPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAM--- 553
+ Q++L+++ +L EE E+K+KV++ +++L+ +
Sbjct: 1601 RQSCQKKLKQMEVQLEEE------------------YEDKQKVLREKRELEGKLATLSDQ 1642
Query: 554 -----YQRNQRLEKALQQ 566
++ +RL K L++
Sbjct: 1643 VNRRDFESEKRLRKDLKR 1660
Score = 47.8 bits (112), Expect = 3e-05
Identities = 81/360 (22%), Positives = 156/360 (43%), Gaps = 65/360 (18%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRD--ELEG------------- 308
+E+E + E E A Q Q+ ++ E+ YE++ + R+ ELEG
Sbjct: 1588 KEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRD 1647
Query: 309 --PEPKGGNKLKQASQKSQRAQQVL-HLQ-VLQLQQEKRQLRQELE-------SLMKEQD 357
E + LK+ AQ +L HL+ ++E QL+ +LE + +K +
Sbjct: 1648 FESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARK 1707
Query: 358 LLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVN----------A 407
+E ++ + A + ++ + E + ++ +L+E Q ++N A
Sbjct: 1708 AMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVA 1767
Query: 408 KASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRK----KNEAEL 463
+AS L AQ+ D + +LE Q+L+ L+ ++E E + K + EA+
Sbjct: 1768 QASRDL---AQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAK- 1823
Query: 464 LREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQREL-ERLRAELREERQGHDQMS 522
+RE LE E +++ +LA + E++ L E +R+ AE RE+ Q +
Sbjct: 1824 IRELETRLEFERTQVKRLESLASRL-----KENMEKLTEERDQRIAAENREKEQ-----N 1873
Query: 523 SGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLE 582
Q + KEE ++ + + + ++ LE L+ L ++A + L+ DL+
Sbjct: 1874 KRLQRQLRDTKEEMGELARKEAEAS-------RKKHELEMDLESL---EAANQSLQADLK 1923
Score = 40.4 bits (93), Expect = 0.005
Identities = 58/270 (21%), Positives = 125/270 (46%), Gaps = 36/270 (13%)
Query: 329 QVLHLQVLQLQQEKRQLRQELESLMKEQ-------DLLETKLRSYEREKTSFGPALEETQ 381
Q+ Q+ +E +QLR +LE KE+ D LE+++ E T E
Sbjct: 1250 QLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESAS 1309
Query: 382 WEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTR----GKLEGLELRTQDLE 437
+ ++ E ++++KE QT+ +A ++ ++ ++ + R ++ G E+ D
Sbjct: 1310 QLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEING-EVDDDDAG 1368
Query: 438 GALRTK----GLELEVCENELQRK-KNEAELLREKVNLLEQELQELRAQAALARDMGPPT 492
G R K E++ + LQ++ +++ E+ ++ LE+ L +L+A + ++
Sbjct: 1369 GEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQ------ 1422
Query: 493 FPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVA 552
+ L+++ +RL AEL++ + H + HE E+K++ ++ +L Q++
Sbjct: 1423 --RALQQLKKKCQRLTAELQDTKL-HLEGQQVRNHE----LEKKQR--RFDSELSQAHEE 1473
Query: 553 MYQRNQRLEKALQQ----LARGDSAGEPLE 578
+ + EK ++ LA S + LE
Sbjct: 1474 AQREKLQREKLQREKDMLLAEAFSLKQQLE 1503
Score = 37.0 bits (84), Expect = 0.052
Identities = 51/244 (20%), Positives = 101/244 (41%), Gaps = 51/244 (20%)
Query: 264 QELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQK 323
QEL++KL + ++ L++S +K L S + R R E E
Sbjct: 1791 QELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFE---------------- 1834
Query: 324 SQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWE 383
QV +L+ +L++ +E L +E+D ++ + REK
Sbjct: 1835 --------RTQVKRLESLASRLKENMEKLTEERD---QRIAAENREKE------------ 1871
Query: 384 VCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQ----DLEGA 439
+ L++QL++++ E+ A + + + LE LE Q DL+ A
Sbjct: 1872 ------QNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLA 1925
Query: 440 LRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL--RAQAALARDMGPPTFPEDV 497
+ G E+E++ +NE + E + ++ EL++ ++ L+++ GP D
Sbjct: 1926 FKRIGDLQAAIEDEMESDENEDLINSEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDD 1985
Query: 498 PALQ 501
+L+
Sbjct: 1986 GSLK 1989
Score = 36.6 bits (83), Expect = 0.067
Identities = 52/236 (22%), Positives = 100/236 (42%), Gaps = 49/236 (20%)
Query: 352 LMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASE 411
++ E+ +E L + EK+S L V ++G ++ L++Q ++ QT N +
Sbjct: 1142 VVDERRAVEELLECLDLEKSSCCMGLSR----VFFRAGTLARLEEQ-RDEQTSRNLTLFQ 1196
Query: 412 IL--GLKAQLKDTRGKLEGLELRTQDLEGALRTKG----------------LELEVCENE 453
G A+ + K++ L +R + + KG +E+++ E +
Sbjct: 1197 AACRGYLARQHFKKRKIQDLAIRCVQ-KNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQ 1255
Query: 454 LQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELRE 513
++ K E + LR K+ E+E ELR + L+ + L +EL +
Sbjct: 1256 IRNKDEEIQQLRSKLEKAEKERNELRLNS---------------DRLESRISELTSELTD 1300
Query: 514 ER---QGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQ 566
ER + Q+ ERL + EKE K+LQ Y A+ ++ + +E + +
Sbjct: 1301 ERNTGESASQLLDAETAERL--RAEKE-----MKELQTQYDALKKQMEVMEMEVME 1349
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.353
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,722,396
Number of Sequences: 37866
Number of extensions: 1167461
Number of successful extensions: 12909
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 374
Number of HSP's successfully gapped in prelim test: 920
Number of HSP's that attempted gapping in prelim test: 6110
Number of HSP's gapped (non-prelim): 4127
length of query: 596
length of database: 18,247,518
effective HSP length: 108
effective length of query: 488
effective length of database: 14,157,990
effective search space: 6909099120
effective search space used: 6909099120
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.