Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 102467242

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|102467242 inner centromere protein antigens 135/155kDa
isoform 2 [Homo sapiens]
         (914 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|102467242 inner centromere protein antigens 135/155kDa isofor...  1794   0.0  
gi|102467235 inner centromere protein antigens 135/155kDa isofor...  1788   0.0  
gi|148746195 trichohyalin [Homo sapiens]                              141   3e-33
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...   132   2e-30
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...   131   3e-30
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...   129   2e-29
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...   128   2e-29
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...   127   6e-29
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...   120   6e-27
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap...   120   6e-27
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap...   120   6e-27
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi...   120   6e-27
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...   118   2e-26
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...   115   2e-25
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...   115   2e-25
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                   114   5e-25
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]           112   2e-24
gi|4503509 eukaryotic translation initiation factor 3, subunit 1...   111   3e-24
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]           110   8e-24
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m...   110   8e-24
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m...   110   8e-24
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]           107   7e-23
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                      103   6e-22
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       102   2e-21
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       102   2e-21
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        102   2e-21
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        102   2e-21
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        102   2e-21
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        102   2e-21
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        102   2e-21

>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 1794 bits (4646), Expect = 0.0
 Identities = 914/914 (100%), Positives = 914/914 (100%)

Query: 1   MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTP 60
           MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTP
Sbjct: 1   MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTP 60

Query: 61  SQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSV 120
           SQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSV
Sbjct: 61  SQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSV 120

Query: 121 LRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAE 180
           LRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAE
Sbjct: 121 LRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAE 180

Query: 181 QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATP 240
           QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATP
Sbjct: 181 QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATP 240

Query: 241 QDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDS 300
           QDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDS
Sbjct: 241 QDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDS 300

Query: 301 QSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLE 360
           QSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLE
Sbjct: 301 QSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLE 360

Query: 361 RLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAAS 420
           RLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAAS
Sbjct: 361 RLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAAS 420

Query: 421 SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS 480
           SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS
Sbjct: 421 SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS 480

Query: 481 SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLEN 540
           SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLEN
Sbjct: 481 SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLEN 540

Query: 541 LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFA 600
           LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFA
Sbjct: 541 LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFA 600

Query: 601 QIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELL 660
           QIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELL
Sbjct: 601 QIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELL 660

Query: 661 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQER 720
           QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQER
Sbjct: 661 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQER 720

Query: 721 RREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 780
           RREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA
Sbjct: 721 RREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 780

Query: 781 GASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPT 840
           GASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPT
Sbjct: 781 GASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPT 840

Query: 841 WARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSPPLQG 900
           WARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSPPLQG
Sbjct: 841 WARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSPPLQG 900

Query: 901 ARVPSSLAYSLKKH 914
           ARVPSSLAYSLKKH
Sbjct: 901 ARVPSSLAYSLKKH 914


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 1788 bits (4631), Expect = 0.0
 Identities = 914/918 (99%), Positives = 914/918 (99%), Gaps = 4/918 (0%)

Query: 1   MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTP 60
           MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTP
Sbjct: 1   MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTP 60

Query: 61  SQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSV 120
           SQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSV
Sbjct: 61  SQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSV 120

Query: 121 LRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAE 180
           LRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAE
Sbjct: 121 LRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAE 180

Query: 181 QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATP 240
           QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATP
Sbjct: 181 QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATP 240

Query: 241 QDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDS 300
           QDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDS
Sbjct: 241 QDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDS 300

Query: 301 QSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLE 360
           QSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLE
Sbjct: 301 QSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLE 360

Query: 361 RLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAAS 420
           RLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAAS
Sbjct: 361 RLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAAS 420

Query: 421 SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS 480
           SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS
Sbjct: 421 SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS 480

Query: 481 SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPK----EKERQ 536
           SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPK    EKERQ
Sbjct: 481 SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQ 540

Query: 537 RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE 596
           RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE
Sbjct: 541 RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE 600

Query: 597 QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 656
           QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH
Sbjct: 601 QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 660

Query: 657 QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 716
           QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA
Sbjct: 661 QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720

Query: 717 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 776
           EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA
Sbjct: 721 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 780

Query: 777 KEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRK 836
           KEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRK
Sbjct: 781 KEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRK 840

Query: 837 PIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSP 896
           PIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSP
Sbjct: 841 PIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSP 900

Query: 897 PLQGARVPSSLAYSLKKH 914
           PLQGARVPSSLAYSLKKH
Sbjct: 901 PLQGARVPSSLAYSLKKH 918


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  141 bits (355), Expect = 3e-33
 Identities = 100/345 (28%), Positives = 196/345 (56%), Gaps = 32/345 (9%)

Query: 442 EPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQR 501
           EP Q  R+KR  ++      EEQ  + E L+    +         ++ R  + +    +R
Sbjct: 132 EPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDE-----ELWRQRQEWQEREER 186

Query: 502 NQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRK--EEAEQLRR------- 552
                    A    ++S     T    D ++  R+ L  LRRK  EE +Q RR       
Sbjct: 187 R--------AEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVF 238

Query: 553 QKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEE 612
           Q+ EE + R+ E V  K EE+L++    R+R  Q +EE+ +++E++  + + + E+ +++
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298

Query: 613 RLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLR 672
           RL  E+  ++      ++ E RR+Q+EE R  +  ++++EERR Q+L ++++E  +++LR
Sbjct: 299 RLRREQQLRR------KQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR 352

Query: 673 KAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERE 732
           +  E +R  +Q  +E+ E+ R +Q RREQ+ R +++  +E+QL  +++ R +++L+ E++
Sbjct: 353 REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412

Query: 733 LQEREKALRLQKEQLQRELEEKK--KKEEQQRLAERQLQEEQEKK 775
           L+ RE+ LR +++QL+RE EE++  +K EQ+R  +R  +E++E++
Sbjct: 413 LR-REQQLR-REQQLRREQEEERHEQKHEQERREQRLKREQEERR 455



 Score =  140 bits (353), Expect = 5e-33
 Identities = 91/266 (34%), Positives = 171/266 (64%), Gaps = 24/266 (9%)

Query: 531 KEKERQRLENLRRKEEAE----QLRRQKVEEDKRRRLE-EVKLKREERLRKVLQARERVE 585
           +E+E +R + LRR++E E    QLRR++ EE + ++L  E +L+RE++LR+  Q R R +
Sbjct: 341 REQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLR-REQ 399

Query: 586 QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 645
           Q++ E++ + EQ   Q+  + +  +E++L  E+ +++   K  +E   +R + E+  R  
Sbjct: 400 QLRREQQLRREQ---QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD 456

Query: 646 WLQQEEEERRHQELLQK---KKEEEQERLRKAAEAKRLAEQREQERREQE--RREQERRE 700
           WL++EEE  RH++  +K   K+++E+ER  +  + +    + +QERREQ+  R ++ERRE
Sbjct: 457 WLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERRE 516

Query: 701 Q--ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQK--EQLQRELEEKK- 755
           Q  +R+E+E R Q+R  +EQ+ RREQE  + +   +E EK L  ++  ++L+RE EE++ 
Sbjct: 517 QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRD 576

Query: 756 ---KKEEQQRLAERQLQEEQEKKAKE 778
              K+EE++R  +++L+ EQE++ ++
Sbjct: 577 QLLKREEERR--QQRLKREQEERLEQ 600



 Score =  140 bits (353), Expect = 5e-33
 Identities = 106/361 (29%), Positives = 202/361 (55%), Gaps = 24/361 (6%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLE-DEELQPPRSKTPSSPCPASK 487
           +Q+ + +Q +  RE  Q  RR++  ++   +L  EQ L  +++L+  +           +
Sbjct: 348 EQQLRREQEEERRE--QQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405

Query: 488 VVRPLRTFLHTVQ--RNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKE 545
            +R  +      Q  R Q L       R   K   +R        K ++ +R + L+R+E
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR---EQRLKREQEERRDWLKREE 462

Query: 546 EAE----QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ 601
           E E    + R+Q+++ D+     E  LK EE  R+  Q R R +Q++ E++++ EQ+  +
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER-REQQLRREQEERREQRLKR 521

Query: 602 IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQE--EEARRLRWLQQEEEERRHQEL 659
            +E  E+  ++RL  E+  ++   ++ E++  R +++  E+ RR + L++E+EERR Q L
Sbjct: 522 QEE--EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQ-L 578

Query: 660 LQKKKEEEQERLRKAAEAK--RLAEQREQERREQERREQERREQERREQERREQERQLAE 717
           L++++E  Q+RL++  E +  +  ++ E ER EQE R ++R ++E  E+ERR+Q  +  E
Sbjct: 579 LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEE 638

Query: 718 QERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 777
           QE RR+Q   Q  RE QER +  RL++E+ +  LE++ K+E ++   E++L EE++++A+
Sbjct: 639 QEERRQQ---QLRREQQERREQ-RLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694

Query: 778 E 778
           E
Sbjct: 695 E 695



 Score =  138 bits (348), Expect = 2e-32
 Identities = 106/398 (26%), Positives = 220/398 (55%), Gaps = 43/398 (10%)

Query: 423 ETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRS-KTPSS 481
           E     +++ + +Q D  R   +  R+++ +++      EE+  E+E+LQ  +  +T   
Sbjct: 150 EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQER-----EERRAEEEQLQSCKGHETEEF 204

Query: 482 PCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVM----KSFIKRNTPLRMDPK---EKE 534
           P       R L       +  +         R       K + KR T LR + +   E+E
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE 264

Query: 535 RQRLENLRRKEEAEQLRRQKVEEDKRRRLEEV----KLKREERLRKVLQARERVEQ---- 586
            QR   L+  EE EQLR+ + +E +R R EE     +L+RE++LR+  +   R +Q    
Sbjct: 265 PQRQRELQ--EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322

Query: 587 -MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK-KMEEVEARRKQ------- 637
             +E +++Q E++  Q+  + E+ +E++L  E+ +++   + + E+ E RR+Q       
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382

Query: 638 ---EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKR-LAEQREQERREQER 693
              E++ RR + L++E++ RR Q+L ++++   +++LR+  + +R   E+R +++ EQER
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442

Query: 694 REQ--ERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQREL 751
           REQ  +R ++ERR+  +RE+E +  EQERR++Q  L+ ++E + RE+ L+L++E+ + + 
Sbjct: 443 REQRLKREQEERRDWLKREEETERHEQERRKQQ--LKRDQEEERRERWLKLEEEERREQQ 500

Query: 752 EEKK---KKEEQQRLAERQLQEEQEKKAKEAAGASKAL 786
           E ++   ++E+++R  +R  ++E+E++ ++   + + L
Sbjct: 501 ERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538



 Score =  138 bits (348), Expect = 2e-32
 Identities = 102/361 (28%), Positives = 197/361 (54%), Gaps = 35/361 (9%)

Query: 441 REPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQ 500
           RE  Q  RR+R  +    E ++E    +  L+    K         + ++     L  ++
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282

Query: 501 RNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKR 560
           R ++        +   +  ++R   LR   +E+ R++ E  R ++E  + + ++ E+  R
Sbjct: 283 RQELRRERQEEEQQQQR--LRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLR 340

Query: 561 RRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAK 620
           R  EE   +RE++LR+  +   R +Q++ E+++  E++  Q+  + +  +E++L  E+  
Sbjct: 341 REQEE---RREQQLRREQEEERREQQLRREQEE--ERREQQLRREQQLRREQQLRREQQL 395

Query: 621 KKAAAKKMEEVEARRKQ---EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEA 677
           ++    + E+   R +Q   E++ RR + L++E+EE RH++  + ++E  ++RL++  E 
Sbjct: 396 RREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ--KHEQERREQRLKREQEE 453

Query: 678 KR--LAEQREQERREQERREQERR---EQERR-------EQERREQERQLAEQERRREQE 725
           +R  L  + E ER EQERR+Q+ +   E+ERR       E+ERREQ+ +  +Q RR ++E
Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE 513

Query: 726 RLQAERELQEREKAL--RLQKE-QLQRELEEKK----KKEEQQRL----AERQLQEEQEK 774
           R +   + QE E+ L  RL+ E QL+RE EE++    K+EE++RL     E++L+ EQE+
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE 573

Query: 775 K 775
           +
Sbjct: 574 R 574



 Score =  138 bits (348), Expect = 2e-32
 Identities = 114/391 (29%), Positives = 201/391 (51%), Gaps = 58/391 (14%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
           Q+E + +Q +  RE  Q  RR++  ++   +L  EQ  E  E Q  R +         + 
Sbjct: 310 QEEERREQQEERRE--QQERREQQEERREQQLRREQE-ERREQQLRREQEEE------RR 360

Query: 489 VRPLRTFLHTVQRNQMLMTPTSAPRSVM---KSFIKRNTPLRMDPKEKERQRLENLRRKE 545
            + LR      +R Q L       R      +  ++R   LR + + +  Q+L   ++  
Sbjct: 361 EQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 420

Query: 546 EAEQLRRQKVEE------DKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKF 599
             +QLRR++ EE      ++ RR + +K ++EER R  L+  E  E+ ++E++KQ     
Sbjct: 421 REQQLRREQEEERHEQKHEQERREQRLKREQEER-RDWLKREEETERHEQERRKQ----- 474

Query: 600 AQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQEL 659
            Q+    E+ + ER  + + +++   ++  E + RR+QEE  R  R  +QEEEER  Q L
Sbjct: 475 -QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER-REQRLKRQEEEERLQQRL 532

Query: 660 -----LQKKKEEEQERLRKAAEAKRLAEQREQER--REQERREQE--RREQERREQE-RR 709
                L++++EE +E+L K  E KRL ++R ++R  REQE R  +  +RE+ERR+Q  +R
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR 592

Query: 710 EQERQLAEQERRREQERLQAER----------------------ELQEREKALRLQKEQL 747
           EQE +L ++ +R E ERL+ E                       E QE  +  +L++EQ 
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652

Query: 748 QRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
           +R  +  K++EE++RL +R  +E +E++ ++
Sbjct: 653 ERREQRLKREEEEERLEQRLKREHEEERREQ 683



 Score =  130 bits (327), Expect = 6e-30
 Identities = 110/394 (27%), Positives = 198/394 (50%), Gaps = 45/394 (11%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDE--EQHLEDEELQPPRSKTPSSPCPAS 486
           Q+E +  +     E  +  +R RS +Q   E +E  EQ L+ EE +    +         
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE 570

Query: 487 KVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRL-------- 538
           +  R  +      +R Q  +      R  ++  +KR    R++ +E+  QRL        
Sbjct: 571 QEERRDQLLKREEERRQQRLKREQEER--LEQRLKREEVERLEQEERREQRLKREEPEEE 628

Query: 539 --ENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE-------RLRKVLQARERVEQMKE 589
             + L + EE E+ R+Q++  +++ R E+ +LKREE       RL++  +   R +++ E
Sbjct: 629 RRQQLLKSEEQEERRQQQLRREQQERREQ-RLKREEEEERLEQRLKREHEEERREQELAE 687

Query: 590 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR----LR 645
           E+++Q  ++      K +   E      ++K  +  +K E    R++QEE+ RR    L+
Sbjct: 688 EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ 747

Query: 646 W-------LQQEEEERRHQELLQKKKEEEQERLRKAAEAK-RLAEQREQERREQERREQE 697
           W        QQ+EEE+R     Q + EE+ ER R+   A+  L EQRE++ R +ER+++E
Sbjct: 748 WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQRE 807

Query: 698 RR---EQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQ--LQRELE 752
           +R   E+E +EQ RR++      +ER +E + L+ E +LQ RE+A +LQ+E+  LQ + E
Sbjct: 808 QRFLPEEEEKEQRRRQR------REREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE 861

Query: 753 EKKKKEEQQRLAERQLQEEQEKKAKEAAGASKAL 786
            ++ +E+++    R   EE+ K+ +    A  AL
Sbjct: 862 RRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL 895



 Score =  129 bits (324), Expect = 1e-29
 Identities = 101/353 (28%), Positives = 192/353 (54%), Gaps = 48/353 (13%)

Query: 429  QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
            Q+  + +Q     E  Q  RR+   +Q   E D +   EDE+L   R +           
Sbjct: 1586 QKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFR-EDEQLLQEREEQQ--------- 1635

Query: 489  VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAE 548
                   LH  +R++  +      R       +R   LR D   K R+  E L ++ E +
Sbjct: 1636 -------LHRQERDRKFLEEEPQLRRQ-----EREQQLRHDRDRKFREE-EQLLQEGEEQ 1682

Query: 549  QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEK 608
            QLRRQ  E D++ R EE +L+R+ER RK LQ  +++      +++++E+KF + ++  ++
Sbjct: 1683 QLRRQ--ERDRKFREEEQQLRRQERERKFLQEEQQL------RRQELERKFREEEQLRQE 1734

Query: 609  AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ 668
             ++E+L  ++  +K     +EE + R ++EE+      L+++E +R+ +E  Q ++E E+
Sbjct: 1735 TEQEQLRRQERYRKI----LEEEQLRPEREEQQ-----LRRQERDRKFREEEQLRQEREE 1785

Query: 669  ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQER-QLAEQERRREQER- 726
            ++LR     ++    RE+E+  QER EQ+ R Q+R  + R E+E+ QL EQE+R  QER 
Sbjct: 1786 QQLRSQESDRKF---REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERD 1842

Query: 727  --LQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 777
               +AE +   +EK+ R ++++L +E E+K+++E +++L E  ++ +Q+++ +
Sbjct: 1843 RQYRAEEQFATQEKS-RREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894



 Score =  127 bits (319), Expect = 5e-29
 Identities = 108/376 (28%), Positives = 199/376 (52%), Gaps = 37/376 (9%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLE--DEELQPPRSKTPSSPCPAS 486
           +Q+ + +Q     +  +  ++ R  +Q   E +EE+H +  ++E +  R K         
Sbjct: 398 EQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE-RRD 456

Query: 487 KVVRPLRTFLHTVQRN-QMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKE 545
            + R   T  H  +R  Q L       R   + ++K     R + +E+  Q+L   + + 
Sbjct: 457 WLKREEETERHEQERRKQQLKRDQEEERR--ERWLKLEEEERREQQERREQQLRREQEER 514

Query: 546 EAEQLRRQKVEEDKRRRL---EEVKLKREERLRKVLQARE--RVEQMKEEK--KKQIEQK 598
             ++L+RQ+ EE  ++RL   ++++ ++EER  ++L+  E  R+EQ + E+  K++ E++
Sbjct: 515 REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER 574

Query: 599 FAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQE 658
             Q+ ++ E+ +++RL  E+ ++     K EEVE  R ++EE R  R  ++E EE R Q+
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVE--RLEQEERREQRLKREEPEEERRQQ 632

Query: 659 LLQKKKEEEQERLRKAAEAKRLAEQREQE-RREQERREQERREQERREQERREQERQLAE 717
           LL   K EEQE  R+    +   E+REQ  +RE+E    E+R +   E+ERREQE    E
Sbjct: 633 LL---KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE 689

Query: 718 QERRRE---------QERLQAERELQEREKALRLQKEQLQR---ELEEKKKKEE------ 759
           QE+ RE         Q +L++E + ++ +   R +K++ QR   E EEK+++ E      
Sbjct: 690 QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ 749

Query: 760 QQRLAERQLQEEQEKK 775
           ++  A RQ QEE++++
Sbjct: 750 EEERAHRQQQEEEQRR 765



 Score =  124 bits (312), Expect = 3e-28
 Identities = 112/402 (27%), Positives = 201/402 (50%), Gaps = 77/402 (19%)

Query: 441  REPPQSARRKRSYKQAVSELDEEQHLEDEELQPP-RSKTPSSPCPASKVVRPLRTFLHTV 499
            RE  Q  R++R  K     L+EEQ L  +E     R +   S  P  K +   +  LH  
Sbjct: 1473 REEQQLHRQERDRKF----LEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQ-LHRQ 1527

Query: 500  QRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDK 559
            QR +  +      R       +R    R D   K R+  E LR++ E +QL RQ  E D+
Sbjct: 1528 QRQRKFLQEEQQLRRQ-----ERGQQRRQDRDRKFREE-EQLRQEREEQQLSRQ--ERDR 1579

Query: 560  RRRLEEVKLKREERLRKVLQARE--RVEQMKEEKKKQIEQKFAQIDEKTEKAKEERL--- 614
            + RLEE K++R+E+ RK ++  +  R ++ +++ +++ ++KF + ++  ++ +E++L   
Sbjct: 1580 KFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQ 1639

Query: 615  -------------------------------AEEKAKKKAAAKKMEEVEARRKQEEEARR 643
                                            EE+  ++   +++   E  RK  EE ++
Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQ 1699

Query: 644  LRWLQ------QEEEERRHQELLQKKKEEE-------------QERLRKAAEAKRLAEQR 684
            LR  +      QEE++ R QEL +K +EEE             QER RK  E ++L  +R
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759

Query: 685  EQERREQERREQERREQERREQERREQERQLAEQERR-REQERLQAERE-----LQEREK 738
            E+++  ++ R+++ RE+E+  QER EQ+ +  E +R+ RE+E+L+ ERE      Q+R+ 
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819

Query: 739  ALRLQKEQLQRELEEKKKKEEQQR--LAERQLQEEQEKKAKE 778
              R ++EQLQ E +E++ ++E+ R   AE Q   +++ + +E
Sbjct: 1820 KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE 1861



 Score =  124 bits (311), Expect = 4e-28
 Identities = 114/403 (28%), Positives = 208/403 (51%), Gaps = 57/403 (14%)

Query: 429 QQEAKTD--QADGPREPPQSARRKRSYKQAVSELDEEQ--HLEDEELQPPRSKTPSSPCP 484
           +QE + D  + +   E  +  RRK+  K+   E   E+   LE+EE +  + +       
Sbjct: 450 EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRR 509

Query: 485 ASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRR- 543
             +  R  R  L   +  + L     + + + +   +R   L    K +E +RLE  RR 
Sbjct: 510 EQEERREQR--LKRQEEEERLQQRLRSEQQLRREQEERREQLL---KREEEKRLEQERRE 564

Query: 544 ---KEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFA 600
              K E E+ R Q ++ ++ RR + +K ++EERL + L+ RE VE++++E++++   K  
Sbjct: 565 QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK-REEVERLEQEERREQRLKRE 623

Query: 601 QIDE-KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL--RWLQQEEEERRHQ 657
           + +E + ++  +    EE+ +++   ++ E  E R K+EEE  RL  R  ++ EEERR Q
Sbjct: 624 EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQ 683

Query: 658 ELLQKKKEEEQERLRK--------------AAEAKRLAEQREQE---RREQERREQERRE 700
           EL ++++E+ +ER++               A ++K  +  R+QE   RR+++  ++ RRE
Sbjct: 684 ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE 743

Query: 701 QERREQERREQERQLAEQERRRE--------------QERLQAERELQE-REKALRLQKE 745
            E + QE     RQ  E+E+RR+              ++RL A   L+E RE+ LR ++ 
Sbjct: 744 SELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEER 803

Query: 746 QL--QRELEEKKKKEE---QQRLAERQLQ---EEQEKKAKEAA 780
           Q   QR L E+++KE+   Q+R  E++LQ   EE++ + +E A
Sbjct: 804 QQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERA 846



 Score =  124 bits (311), Expect = 4e-28
 Identities = 108/381 (28%), Positives = 198/381 (51%), Gaps = 44/381 (11%)

Query: 429  QQEAKTDQADGPREPPQSARRKRSYKQAVSELD-----EEQHLEDEELQPPRSKTPSSPC 483
            Q+EAK       +E  Q  R +R  K+   E D     EEQ L++ E QP R +      
Sbjct: 1304 QKEAKRRDRKS-QEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKF 1362

Query: 484  PASKVVRPL--RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENL 541
               ++      R FL   QR +         +   + F+K    LR   +E++ ++  + 
Sbjct: 1363 REEELRHQEQGRKFLEEEQRLRR--------QERERKFLKEEQQLRCQEREQQLRQDRDR 1414

Query: 542  RRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ 601
            + +EE +QL RQ  E D++ R EE +++R+ER RK L+  +++ Q +  K ++ EQ   +
Sbjct: 1415 KFREEEQQLSRQ--ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE 1472

Query: 602  IDE----KTEKAK-----EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ---- 648
             +E    + E+ +     E++L  ++  +K   +++   E  RK  EE ++L   Q    
Sbjct: 1473 REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRK 1532

Query: 649  --QEEEERRHQELLQKKKEE------EQERLRKAAEAKRLAEQREQERREQERREQERRE 700
              QEE++ R QE  Q+++++      E+E+LR+  E ++L+ Q    +   E ++  R+E
Sbjct: 1533 FLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQE 1592

Query: 701  QERREQERREQ-ERQLAEQERRREQERLQAERE--LQEREKALRLQKEQLQRELEEKKKK 757
            QER+  E  +Q  RQ  +Q+ R+E++R   E E  LQERE+    ++E+ ++ LEE+ + 
Sbjct: 1593 QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQL 1652

Query: 758  EEQQRLAERQLQEEQEKKAKE 778
              Q+R  E+QL+ ++++K +E
Sbjct: 1653 RRQER--EQQLRHDRDRKFRE 1671



 Score =  122 bits (307), Expect = 1e-27
 Identities = 94/279 (33%), Positives = 163/279 (58%), Gaps = 33/279 (11%)

Query: 521  KRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQA 580
            +R   L   P  +E+ R E    +EE E+L+R+  E +KRRR E+ +  REE      Q 
Sbjct: 884  RRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE--EREKRRRQEQERQYREEE-----QL 936

Query: 581  RERVEQM----KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRK 636
            ++  EQ+    +E++++Q  ++  + D+K ++ +E+ L EE  K++   ++ +  E    
Sbjct: 937  QQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEEL 996

Query: 637  QEEEARRLRWLQQEEEERRHQELLQ--KKKEE---EQERLRKAAEAKRLAEQREQERREQ 691
            Q+EE + LR   +E E+RR QE  +  +KK+E   E+E+L +    KR  ++RE++ RE+
Sbjct: 997  QQEEEQLLR---EEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE 1053

Query: 692  ERREQERRE---QERREQERREQERQLA-EQERRREQERLQAE----RELQEREKALRLQ 743
            E  +QE  +   +ER  + R+E ERQ   E+E ++E+E+L  E    R  QERE+  R +
Sbjct: 1054 EELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCR-E 1112

Query: 744  KEQLQRE----LEEKKKKEEQQRLAERQLQEEQEKKAKE 778
            +E+LQ+E    L E+++K  +Q L ERQ +EE+E + +E
Sbjct: 1113 EEELQQEEEQLLREEREKRRRQEL-ERQYREEEEVQQEE 1150



 Score =  122 bits (305), Expect = 2e-27
 Identities = 116/403 (28%), Positives = 192/403 (47%), Gaps = 79/403 (19%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSEL---DEEQHLEDEELQPPRSKTPSSPCPA 485
           +QE + DQ     E  +  R KR  ++ + +    +E + LE EE +  R K        
Sbjct: 570 EQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK-------- 621

Query: 486 SKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKE 545
                  R      +R Q+L +     R        R   LR + +E+  QRL   +R+E
Sbjct: 622 -------REEPEEERRQQLLKSEEQEER--------RQQQLRREQQERREQRL---KREE 663

Query: 546 EAEQL-RRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQ-KFAQID 603
           E E+L +R K E ++ RR +E+  + +E+ R+ +++R    Q + E +    Q K     
Sbjct: 664 EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRP 723

Query: 604 EKTEKAKEERLAEEKAKKKAAAKKMEEVEA--RRKQEEEARR---LRWLQQEEEERRHQE 658
            K E  +  +  EEK +++ +  + +E E   R++QEEE RR    +W  +E+ ER  Q 
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQR 783

Query: 659 LLQKKKEEEQERLRKAAEAKRLAEQR---EQERREQERREQERREQE-----------RR 704
           L  +    EQ   +  AE ++  EQR   E+E +EQ RR++  RE+E           RR
Sbjct: 784 LSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRR 843

Query: 705 E---------------QERREQERQ--------LAEQERRREQERLQAERELQER----E 737
           E               QERR  + Q          E+ER+R +  L A+  LQE+    +
Sbjct: 844 ERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903

Query: 738 KALRLQKEQLQRELEEKKKKEEQQR--LAERQLQEEQEKKAKE 778
           + L+ ++E+LQRE  EK++++EQ+R    E QLQ+E+E+  +E
Sbjct: 904 QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLRE 946



 Score =  120 bits (301), Expect = 6e-27
 Identities = 109/358 (30%), Positives = 187/358 (52%), Gaps = 33/358 (9%)

Query: 430  QEAKTDQADGPREPPQSARRKRSY--KQAVSE-LDEEQHL---EDEELQPPRSKTPSSPC 483
            QE + DQ    +   +  RR+ +   K A+ E L +EQ L   E+EELQ    +      
Sbjct: 866  QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRR-- 923

Query: 484  PASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRR 543
               +  R  R      Q  + L+      R       +R    R   K+K+ Q+ E    
Sbjct: 924  --QEQERQYREEEQLQQEEEQLLREEREKR-------RRQERERQYRKDKKLQQKEEQLL 974

Query: 544  KEEAEQLRRQ----KVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKF 599
             EE E+ RRQ    K  E++  + EE +L REER ++  Q  ER  + K+E +++ EQ  
Sbjct: 975  GEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLL 1034

Query: 600  AQIDEKTEKAKEERLAEEKAKKKAAAKKM--EEVEARRKQEEEA--RRLRWLQQEEEERR 655
             +  EK    + ER   E+ + +   +++  EE E RR+QE E   R+   LQQEEE+  
Sbjct: 1035 REEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLL 1094

Query: 656  HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQL 715
             +E  +++++E + + R+  E ++  EQ  +E RE+ RR++  R+    E+ ++E+E+ L
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154

Query: 716  AEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQE 773
             E+  +R ++ L  ER+ +E E+ L+ ++EQL RE E++K+++E+    ERQ +EE+E
Sbjct: 1155 REEPEKRRRQEL--ERQYREEEE-LQQEEEQLLRE-EQEKRRQER----ERQYREEEE 1204



 Score =  119 bits (299), Expect = 1e-26
 Identities = 104/387 (26%), Positives = 194/387 (50%), Gaps = 58/387 (14%)

Query: 442  EPPQSARRKRSYKQAVSELDEEQHL-----------EDEELQPPRSKTPSSPCPASKVVR 490
            E  Q  R++R  ++ +  L+EE+ L           E++ LQ  + +  S      +  R
Sbjct: 816  EKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWR 875

Query: 491  PLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQL 550
                     +R+ +   P     ++ +   K    L+ + +E +R+  E  RR+E+  Q 
Sbjct: 876  WQLEEERKRRRHTLYAKP-----ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930

Query: 551  RRQKV---EEDKRRRLEEVKLKREERLR-----KVLQARER--VEQMKEEKKKQIEQKFA 600
            R ++    EE++  R E  K +R+ER R     K LQ +E   + +  E++++Q  +K  
Sbjct: 931  REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990

Query: 601  QIDEKTEKAKEERLAEEKAKKKAAA-----KKMEEVEARRKQE-EEARRLRWLQQEEEER 654
            + +E+ ++ +E+ L EE+ K++        +K +E++   +Q   E R  R LQ+ E + 
Sbjct: 991  REEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050

Query: 655  RHQELLQKKKEE---EQERLRKAAEAKRLAEQREQERREQE---------RREQERREQE 702
            R +E LQ+++E+   E+   R+  E +R   + E+ ++E+E         RR QER  Q 
Sbjct: 1051 REEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC 1110

Query: 703  RREQERREQERQLAEQERR-----------REQERLQAERELQEREKALRLQKEQLQREL 751
            R E+E +++E QL  +ER            RE+E +Q E E   RE+  + ++++L+R+ 
Sbjct: 1111 REEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQY 1170

Query: 752  EEKKKKEEQQRLAERQLQEEQEKKAKE 778
             E   +EE Q+  E+ L+EEQEK+ +E
Sbjct: 1171 RE---EEELQQEEEQLLREEQEKRRQE 1194



 Score =  119 bits (298), Expect = 1e-26
 Identities = 75/270 (27%), Positives = 161/270 (59%), Gaps = 21/270 (7%)

Query: 527 RMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVE- 585
           R +P++++ +     RR+++ ++  R+  E +++   +E   +R+ + R     R+R E 
Sbjct: 121 RFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEW 180

Query: 586 QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ-------- 637
           Q +EE++ + EQ  +    +TE+  +E     +   +   K  EE + +R++        
Sbjct: 181 QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQE 240

Query: 638 --EEEARRLRWLQQEEEERRHQELLQKKKE--EEQERLRKAAEAKRLAEQREQERREQER 693
             E+E R+   + ++EEE+  +E  Q+++E  EE+E+LRK  E + L  +R++E ++Q+R
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKL-ERQELRRERQEEEQQQQR 299

Query: 694 REQERREQERREQERREQERQLAEQERRREQERLQAEREL-----QEREKALRLQKEQLQ 748
             +E++ + ++E+ERREQ+ +  EQ+ RREQ+  + E++L     + RE+ LR ++E+ +
Sbjct: 300 LRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEER 359

Query: 749 RELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
           RE + ++++EE++R  E+QL+ EQ+ + ++
Sbjct: 360 REQQLRREQEEERR--EQQLRREQQLRREQ 387



 Score =  119 bits (297), Expect = 2e-26
 Identities = 98/365 (26%), Positives = 191/365 (52%), Gaps = 39/365 (10%)

Query: 436  QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF 495
            +AD  +    S  RK+  ++   E +E++   + ELQ    +         +  R     
Sbjct: 711  EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQ 770

Query: 496  LHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKV 555
                ++++      SA   + +   +R   LR + +++  QR   L  +EE EQ RRQ+ 
Sbjct: 771  WQAEEKSERGRQRLSARPPLRE---QRERQLRAEERQQREQRF--LPEEEEKEQRRRQRR 825

Query: 556  EEDKRRRL--EEVKLKREERLRKVLQARERVE-------------------QMKEEKKKQ 594
            E +K  +   EE +L+R ER +++ +  + ++                   Q++EE+K++
Sbjct: 826  EREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR 885

Query: 595  IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA--RRLRWLQQEEE 652
                +A+   + +  KE++L +E+ ++     + EE E RR+QE+E   R    LQQEEE
Sbjct: 886  RHTLYAKPALQEQLRKEQQLLQEEEEE----LQREEREKRRRQEQERQYREEEQLQQEEE 941

Query: 653  ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQ-ERREQERREQERREQERREQ 711
            +   +E   ++K   QER R+  + K+L ++ EQ   E+ E+R ++ RE++ RE+E  +Q
Sbjct: 942  QLLREE---REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ 998

Query: 712  ERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQR--LAERQLQ 769
            E +   +E R ++ R + ER+ +++++ L+ ++EQL RE  EK++ +E++R    E +LQ
Sbjct: 999  EEEQLLREEREKRRRQEWERQYRKKDE-LQQEEEQLLREEREKRRLQERERQYREEEELQ 1057

Query: 770  EEQEK 774
            +E+E+
Sbjct: 1058 QEEEQ 1062



 Score =  116 bits (290), Expect = 1e-25
 Identities = 101/365 (27%), Positives = 191/365 (52%), Gaps = 36/365 (9%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
           +QE + +Q    RE P+  RR++  K    E   +Q L  E+ Q  R +         ++
Sbjct: 611 EQEERREQRL-KREEPEEERRQQLLKSEEQEERRQQQLRREQ-QERREQRLKREEEEERL 668

Query: 489 VRPLRTFLHTVQRNQMLMTPTSAP-RSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEA 547
            + L+      +R Q L        R  +KS I +    +++ +   RQ     R +++ 
Sbjct: 669 EQRLKREHEEERREQELAEEEQEQARERIKSRIPK-WQWQLESEADARQSKVYSRPRKQE 727

Query: 548 EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTE 607
            Q RRQ+ EE +RRR  E++ + EER  +        +Q +EE+++    ++ Q +EK+E
Sbjct: 728 GQRRRQEQEEKRRRRESELQWQEEERAHR--------QQQEEEQRRDFTWQW-QAEEKSE 778

Query: 608 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKE-- 665
           + ++   A    +++    +  ++ A  +Q+ E R L   ++EE+E+R ++  +++KE  
Sbjct: 779 RGRQRLSARPPLREQ----RERQLRAEERQQREQRFLP--EEEEKEQRRRQRREREKELQ 832

Query: 666 --EEQERLRKAAEAKRLAEQRE--QERREQERREQERREQERREQERREQERQ------- 714
             EE+E+L++   A++L E+ +  QE +E+ R +++RR+Q+ R Q   E++R+       
Sbjct: 833 FLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892

Query: 715 --LAEQERRREQERLQAERELQ--EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 770
             L EQ R+ +Q   + E ELQ  EREK  R ++E+  RE E+ +++EEQ    ER+ + 
Sbjct: 893 PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR 952

Query: 771 EQEKK 775
            QE++
Sbjct: 953 RQERE 957



 Score =  115 bits (289), Expect = 1e-25
 Identities = 112/431 (25%), Positives = 213/431 (49%), Gaps = 40/431 (9%)

Query: 374  EQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPN------PKPAASSPETPSA 427
            +++E  +E E +   EPE             + E+             K      E    
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141

Query: 428  GQQEAKTDQADGPREPPQSARRK---RSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCP 484
             ++E + ++    RE P+  RR+   R Y++      EE+ L  EE +  R +       
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYRE 1201

Query: 485  ASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRK 544
              ++ R  R   +  +  +  +     P    ++ ++ N   ++  K +E ++   L   
Sbjct: 1202 EEELQRQKRKQRYRDEDQRSDLKWQWEPEK--ENAVRDN---KVYCKGRENEQFRQL--- 1253

Query: 545  EEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER----VEQMKEEKKKQIEQKFA 600
             E  QLR ++ ++D +  L E + +  E+ R+  Q R+R     EQ++ E++K+ +++  
Sbjct: 1254 -EDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDR 1312

Query: 601  QIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA---RRLRWLQQEEEERRHQ 657
            +  E+ +  +EER  EEK +++   +K  E E   ++ EE    R+ R  +  EEE RHQ
Sbjct: 1313 KSQEEKQLLREER--EEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370

Query: 658  ELLQKKKEEEQERLRKAAEAKRLAEQRE---QERREQERREQERREQERREQ-ERREQER 713
            E  +K  EEEQ   R+  E K L E+++   QER +Q R++++R+ +E  +Q  R+E++R
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430

Query: 714  QLAEQE---RRREQER--LQAEREL-QEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ 767
            +  E+E   RR+E+ER  L+ E++L QER +  R +++ LQ   E++  ++E+ R   + 
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR---KF 1487

Query: 768  LQEEQEKKAKE 778
            L+EEQ+ + +E
Sbjct: 1488 LEEEQQLRRQE 1498



 Score =  114 bits (284), Expect = 5e-25
 Identities = 180/771 (23%), Positives = 318/771 (41%), Gaps = 94/771 (12%)

Query: 35   EEIQEE--AERMFTREFSKEPELMPKTPSQKN---RRKKRRISYVQDENRDPI-RRRLSR 88
            E +Q+   +E+   RE  +  E + K   +K     R+++R+   Q+E RD + +R   R
Sbjct: 526  ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEER 585

Query: 89   RKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATMALAAPSSPTPES 148
            R+ R  +    RL  +   E++  +  E     RR  R                 P  E 
Sbjct: 586  RQQRLKREQEERLEQRLKREEVERLEQEE----RREQRLKR------------EEPEEER 629

Query: 149  PTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTS 208
               L K  E    + Q     ++   +++  EQ + +    E L + L            
Sbjct: 630  RQQLLKSEEQEERRQQ-----QLRREQQERREQRLKREEEEERLEQRLKREHEEERR--E 682

Query: 209  QGIPTSDEESTPKKSKARI------LES---ITVSSLMATPQDPKGQGVGTGRSASKLRI 259
            Q +   ++E   ++ K+RI      LES      S + + P+  +GQ     +   + R 
Sbjct: 683  QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742

Query: 260  AQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLA 319
                    +  A       E+        +F+    +   S+  R       S  P +  
Sbjct: 743  ESELQWQEEERAHRQQQEEEQ------RRDFTWQWQAEEKSERGRQR----LSARPPLRE 792

Query: 320  QKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVE-VPQKVGSEQKEP 378
            Q+   +  +E   +R  R L ++  +E     R      L+ L   E + ++  ++Q + 
Sbjct: 793  QRERQLRAEERQ-QREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851

Query: 379  PEEAEPVAAAEPEVPENNGNNSWP---HNDTEIANSTPNPKPAASSPETPSAGQQEAKTD 435
             E+            E   +  W      + +    T   KPA    E     QQ  + +
Sbjct: 852  EEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQ--EQLRKEQQLLQEE 909

Query: 436  QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF 495
            + +  RE  +  RR+   +Q      EE+ L+ EE Q  R +         +  R  R  
Sbjct: 910  EEELQREEREKRRRQEQERQ----YREEEQLQQEEEQLLREEREKRRRQERE--RQYRKD 963

Query: 496  LHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKV 555
                Q+ + L+      R       +R    +   +E+E Q+ E    +EE E+ RRQ+ 
Sbjct: 964  KKLQQKEEQLLGEEPEKR-------RRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016

Query: 556  EEDKRRR----LEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 611
            E   R++     EE +L REER ++ LQ RER  + +EE +++ EQ   +  E   + + 
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076

Query: 612  ERL--AEEKAKKKAAAKKMEEVEARRKQEEE--ARRLRWLQQEEEERRHQELLQKKKEEE 667
            ER    EE+ +++      EE E RR+QE E   R    LQQEEE+   +E  +++++E 
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136

Query: 668  QERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERL 727
            + + R+  E ++  EQ  +E  E+ RR QE   Q R E+E +++E QL     R EQE+ 
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRR-QELERQYREEEELQQEEEQLL----REEQEKR 1191

Query: 728  QAERELQEREKALRLQKEQLQRELEEKKKKE---EQQRLAERQLQEEQEKK 775
            + ERE Q RE          + EL+ +K+K+   ++ + ++ + Q E EK+
Sbjct: 1192 RQERERQYRE----------EEELQRQKRKQRYRDEDQRSDLKWQWEPEKE 1232



 Score =  113 bits (283), Expect = 7e-25
 Identities = 79/259 (30%), Positives = 153/259 (59%), Gaps = 15/259 (5%)

Query: 531  KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
            +E++++     R+ +E +QL R++ EE +RR+  + K + EE+L   LQ RE     ++E
Sbjct: 1301 REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQL---LQEREEQPLRRQE 1357

Query: 591  KKKQIEQKFAQIDEKTEK--AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648
            + ++  ++  +  E+  K   +E+RL  ++ ++K   ++ +     R+Q+    R R  +
Sbjct: 1358 RDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFR 1417

Query: 649  QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE-QERREQERREQERREQERREQE 707
            +EE++   QE  +K +EEEQ+  R+  E K L E+++ ++ R ++ RE+E+  QER EQ+
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ 1477

Query: 708  --RREQERQLAEQE---RRREQERLQAEREL--QEREKALRLQKEQLQRELEEKK--KKE 758
              R+E++R+  E+E   RR+E++R   E+EL  QE E+    +++QL R+  ++K  ++E
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEE 1537

Query: 759  EQQRLAERQLQEEQEKKAK 777
            +Q R  ER  Q  Q++  K
Sbjct: 1538 QQLRRQERGQQRRQDRDRK 1556



 Score =  113 bits (283), Expect = 7e-25
 Identities = 101/396 (25%), Positives = 199/396 (50%), Gaps = 80/396 (20%)

Query: 448  RRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMT 507
            R+ R  +Q +S  + ++   +EE Q  R +               R FL   +  Q L  
Sbjct: 1414 RKFREEEQQLSRQERDRKFREEEQQVRRQERE-------------RKFL---EEEQQLRQ 1457

Query: 508  PTSAPRSVMKSFIKRNTPLRMDPKEKERQRLEN---LRRKEEAEQLRRQKV--EEDKRRR 562
                     +  ++     ++  +E++R+ LE    LRR+E   + R Q++  +E +R+ 
Sbjct: 1458 ERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKF 1517

Query: 563  LEEVK-LKREERLRKVLQARERVEQMK--EEKKKQIEQKFAQIDEKTEKAKEE------- 612
            LEE + L R++R RK LQ  +++ + +  +++++  ++KF + ++  ++ +E+       
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER 1577

Query: 613  ----RLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW------------LQQEEEERRH 656
                RL E+K +++   +K  E E + +++E  ++LR             LQ+ EE++ H
Sbjct: 1578 DRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLH 1637

Query: 657  QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER----REQE 712
            ++   +K  EE+ +LR+    ++L   R+++ RE+E+  QE  EQ+ R QER    RE+E
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE 1697

Query: 713  RQLAEQERRR-------------------EQERLQAERELQEREKALR----LQKEQLQR 749
            +QL  QER R                   E+E+L+ E E ++  +  R    L++EQL+ 
Sbjct: 1698 QQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRP 1757

Query: 750  ELEEK--KKKEEQQRLAE----RQLQEEQEKKAKEA 779
            E EE+  +++E  ++  E    RQ +EEQ+ +++E+
Sbjct: 1758 EREEQQLRRQERDRKFREEEQLRQEREEQQLRSQES 1793



 Score =  113 bits (282), Expect = 9e-25
 Identities = 87/269 (32%), Positives = 158/269 (58%), Gaps = 24/269 (8%)

Query: 531  KEKERQRLENLRRK-EEAEQLRRQKVEEDKRR---RLEEVKLKREERLRKVLQARERVEQ 586
            +E+ER+R +   R   E EQL R++ +E KRR     EE +L REER  K  + R+  ++
Sbjct: 1279 REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK--RRRQETDR 1336

Query: 587  MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 646
               E+++ ++++  Q   + E+ ++ R  EE   ++   K +EE +  R+QE E + L+ 
Sbjct: 1337 KFREEEQLLQEREEQPLRRQERDRKFR-EEELRHQEQGRKFLEEEQRLRRQERERKFLKE 1395

Query: 647  LQQEEEERRHQELLQ----KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQE 702
             QQ   + R Q+L Q    K +EEEQ+  R+  + K   E+++  R+E+ER+  E  +Q 
Sbjct: 1396 EQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQL 1455

Query: 703  RREQER--REQERQLAEQER----RREQER--LQAERELQEREKALRLQKEQLQRELEEK 754
            R+E+ R  RE+E+ L E+E     R+E++R  L+ E++L+ +E+  + ++++L+ +  E+
Sbjct: 1456 RQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPER 1515

Query: 755  KKKEEQQRLAERQ-----LQEEQEKKAKE 778
            K  EE+Q+L  +Q     LQEEQ+ + +E
Sbjct: 1516 KFLEEEQQLHRQQRQRKFLQEEQQLRRQE 1544



 Score =  112 bits (279), Expect = 2e-24
 Identities = 121/501 (24%), Positives = 230/501 (45%), Gaps = 48/501 (9%)

Query: 304  RHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLL 363
            RH+  A  +   Q L ++  L+ ++E  ++R  R   ++  +E             E+LL
Sbjct: 886  RHTLYAKPALQEQ-LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944

Query: 364  NVEVPQKVGSEQ-------KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPN-- 414
              E  ++   E+       K+  ++ E +   EPE             + E+        
Sbjct: 945  REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL 1004

Query: 415  ----PKPAASSPETPSAGQQEAKTDQADGPREPPQSAR---RKRSYKQAVSELDEEQHLE 467
                 K      E     + E + ++    RE  +  R   R+R Y++      EE+ L 
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL 1064

Query: 468  DEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLR 527
             EE +  R +         ++ R  R      Q  + L+      R       +R    R
Sbjct: 1065 GEERETRRRQ---------ELERQYRKEEELQQEEEQLLREEPEKR-------RRQERER 1108

Query: 528  MDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVE-- 585
               +E+E Q+ E    +EE E+ RRQ++E   R   EEV+ + E+ LR+  + R R E  
Sbjct: 1109 QCREEEELQQEEEQLLREEREKRRRQELERQYREE-EEVQQEEEQLLREEPEKRRRQELE 1167

Query: 586  -QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 644
             Q +EE++ Q E++   + E+ EK ++ER  + + +++   +K ++   R + E++   L
Sbjct: 1168 RQYREEEELQQEEE-QLLREEQEKRRQERERQYREEEELQRQKRKQ---RYRDEDQRSDL 1223

Query: 645  RWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER-REQER 703
            +W  + E+E   ++     K  E E+ R+  +++    Q +Q+ +     +QER REQER
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283

Query: 704  REQERREQERQLAEQ-ERRREQERLQAERELQEREKALRLQKEQLQRELE-EKKKKEEQQ 761
            R  ++R++     EQ ER  ++E  + +R+ QE ++ LR ++E+ +R  E ++K +EE+Q
Sbjct: 1284 RRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQ 1343

Query: 762  RLAERQLQ----EEQEKKAKE 778
             L ER+ Q    +E+++K +E
Sbjct: 1344 LLQEREEQPLRRQERDRKFRE 1364



 Score =  107 bits (267), Expect = 5e-23
 Identities = 73/229 (31%), Positives = 139/229 (60%), Gaps = 20/229 (8%)

Query: 563 LEEVKLKREERLRKVLQARERVEQMK--EEKKKQIEQKFAQIDEKTEKAKEERLAE--EK 618
           L+E K  R +    +LQ R + E  +  E + +Q+E++  Q   +  + +E  LAE  E+
Sbjct: 95  LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154

Query: 619 AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK--------EEEQER 670
           ++K+   +++E+ + +R+ EE  R+ +  Q+ EE R  +E LQ  K        +EEQ R
Sbjct: 155 SEKQ---ERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLR 211

Query: 671 LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE 730
            R+  E +R   +  +E+++Q R  Q+R  QE  E+E R++E  L ++E + ++E  Q +
Sbjct: 212 RRELLELRR---KGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268

Query: 731 RELQEREKALR-LQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
           RELQE E+ LR L++++L+RE +E+++++++ R  E+QL+ +QE++ +E
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLR-REQQLRRKQEEERRE 316



 Score =  107 bits (267), Expect = 5e-23
 Identities = 73/251 (29%), Positives = 152/251 (60%), Gaps = 19/251 (7%)

Query: 531 KEKERQRLENLRRK--EEAEQLRRQKVEEDKRRRLE-EVKLKREERLRKVLQARERVEQM 587
           +E++++R E   R+  EE  Q RRQK +E +R   E E + +++ERL       +R  Q 
Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLE------QRDRQR 168

Query: 588 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 647
           ++E+  +  Q++ + +E+  +A+EE+L  +  K     +  +E + RR++  E RR    
Sbjct: 169 RDEELWRQRQEWQEREER--RAEEEQL--QSCKGHETEEFPDEEQLRRRELLELRRKGRE 224

Query: 648 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 707
           +++++ R  Q+ + +  EEE++  RK     R  E++ QE   Q +RE +  E++ R+ E
Sbjct: 225 EKQQQRRERQDRVFQ--EEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282

Query: 708 RREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ 767
           R+E  R+   QE  ++Q+RL+ E++L+ +++  R ++++ +RE +E+++++E++R  E+Q
Sbjct: 283 RQELRRE--RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR--EQQ 338

Query: 768 LQEEQEKKAKE 778
           L+ EQE++ ++
Sbjct: 339 LRREQEERREQ 349



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 62/268 (23%), Positives = 127/268 (47%), Gaps = 14/268 (5%)

Query: 429  QQEAKTDQADGP-REPPQSARRKRSYKQAVSELDEEQHLEDEELQPP-RSKTPSSPCPAS 486
            +Q+ +  + D   RE  Q  RR+   ++    L EEQ L  +EL+   R +         
Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQERERKF---LQEEQQLRRQELERKFREEEQLRQETEQ 1737

Query: 487  KVVRPLRTFLHTVQRNQML--MTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRK 544
            + +R    +   ++  Q+          R       +    LR + +E++ +  E+ R+ 
Sbjct: 1738 EQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKF 1797

Query: 545  EEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ--IEQKFAQI 602
             E EQLR+++ E+  R +  + K + EE   + LQ  E+ +++++E+ +Q   E++FA  
Sbjct: 1798 REEEQLRQEREEQQLRPQQRDGKYRWEE---EQLQLEEQEQRLRQERDRQYRAEEQFATQ 1854

Query: 603  DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ-QEEEERRHQELLQ 661
            ++   + +E    EE+ +++   +K+ E   RR+Q+EE R  +  + + +E + H  LL+
Sbjct: 1855 EKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914

Query: 662  KKKEE-EQERLRKAAEAKRLAEQREQER 688
                +     +R +   + + EQR Q R
Sbjct: 1915 PGTHQFASVPVRSSPLYEYIQEQRSQYR 1942



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 39/109 (35%), Positives = 64/109 (58%), Gaps = 9/109 (8%)

Query: 676 EAKRLAEQREQERREQERREQERREQERREQERRE-QERQLAEQE-RRREQERLQAEREL 733
           +A  L E++      +E   Q+RR++E  +Q R E ++RQL E+  +RR Q+R + EREL
Sbjct: 91  QATGLDEEKRARCDGKESLLQDRRQEE--DQRRFEPRDRQLEEEPGQRRRQKRQEQEREL 148

Query: 734 ----QEREKALRLQKEQLQRELEEK-KKKEEQQRLAERQLQEEQEKKAK 777
               ++ EK  RL++   QR  EE  ++++E Q   ER+ +EEQ +  K
Sbjct: 149 AEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK 197



 Score = 31.6 bits (70), Expect = 3.5
 Identities = 23/88 (26%), Positives = 45/88 (51%), Gaps = 11/88 (12%)

Query: 33   WLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDP------IRRRL 86
            +L+E Q+   +   R+F +E +L  +T  ++ RR++R    +++E   P      +RR+ 
Sbjct: 1709 FLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQE 1768

Query: 87   SRRKSRS-----SQLSSRRLRSKDSVEK 109
              RK R       +   ++LRS++S  K
Sbjct: 1769 RDRKFREEEQLRQEREEQQLRSQESDRK 1796


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score =  132 bits (331), Expect = 2e-30
 Identities = 96/290 (33%), Positives = 175/290 (60%), Gaps = 44/290 (15%)

Query: 529 DPKEKERQRLENLRRKEEA-----EQLRRQKV----EEDKRRRLEEVKLKREERLRKVLQ 579
           + +EK R++ E +RR+EE      E++RRQ+     +E+K RRLEE+  ++EE++R++ +
Sbjct: 325 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEE 384

Query: 580 ARERVEQMKE-EKKKQIEQKFAQIDEKTEKA-----KEERLAEEKAKKKAAAKKMEEVEA 633
                E+++E E+K+Q E+K  + +++ E+      +EE++ E++ K +   KKM   E 
Sbjct: 385 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEE 444

Query: 634 RRKQEEEARRLRWLQQEEEERRHQELL--------QKKKEEEQERLRKAAEA-------- 677
           +  ++E+ R     Q++EE  R +E +        QK+K  EQE++RK  E         
Sbjct: 445 KIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKM 504

Query: 678 ----KRLAEQREQERREQER-REQER--REQER--REQER--REQERQLAEQERR-REQE 725
               +++ EQ E+  R++E+ REQE   REQE   REQE   +EQE ++ EQE + +EQE
Sbjct: 505 HDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQE 564

Query: 726 RLQAERE-LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 774
           +++ + E ++E+E+ +R QKE+++ + E+  ++EE+ R  E  +QE++EK
Sbjct: 565 KMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEK 614



 Score =  125 bits (314), Expect = 2e-28
 Identities = 83/268 (30%), Positives = 165/268 (61%), Gaps = 28/268 (10%)

Query: 529 DPKEKERQRLENLRRKEEAEQLRRQKV----EEDKRRRLEEVKLKREERLRKVLQARERV 584
           + +EK R++ E +R +EE  ++RRQ+     +E+K RR EE+  ++EE++R++    E +
Sbjct: 318 EQEEKIREQEEKIREQEE--KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRL----EEM 371

Query: 585 EQMKEEKKKQIEQKF---AQIDEKTEK-AKEERLAEEKAKKKAAAKKMEEVEARRKQEEE 640
              KEEK +++E+K     +I E+ EK  +EE++ E++ +++  AK   + E  R+QEE+
Sbjct: 372 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 431

Query: 641 ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER-R 699
            R        +EE+ H++   +++E+ QE+     + +++ EQ E  R++++  EQE+ R
Sbjct: 432 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIR 491

Query: 700 EQE----RREQERREQERQLAEQER---RREQERLQAERELQEREKALRLQKEQLQR--- 749
           +QE    R+E++  +QE ++ EQE    R+E++  + E +++E+E+ +R Q+E +Q    
Sbjct: 492 KQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEE 551

Query: 750 ---ELEEKKKKEEQQRLAERQLQEEQEK 774
              E EEK +++E+ R  E +++E++EK
Sbjct: 552 KMGEQEEKMQEQEKMRRQEEKIREQEEK 579



 Score =  124 bits (311), Expect = 4e-28
 Identities = 104/464 (22%), Positives = 231/464 (49%), Gaps = 40/464 (8%)

Query: 318 LAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKE 377
           L +K  LV  ++S ++   + L +K                LER   +   Q++ +E   
Sbjct: 226 LQEKLQLVESEKSEIQLNVKELKRK----------------LERAKLLLPQQQLQAEADH 269

Query: 378 PPEEAEPVAAA-EPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQ 436
             +E + V+A  + +V EN     W   + +        +      E     Q+E   +Q
Sbjct: 270 LGKELQSVSAKLQAQVEENE---LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ 326

Query: 437 ADGPREPPQSARRKRSYKQAVSELDEEQHLEDE---ELQPPRSKTPSSPCPASKVVRPLR 493
            +  RE  +  RR+   ++ + E +E+   ++E   E +    +         + +R L 
Sbjct: 327 EEKIREQEEKMRRQ---EEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELE 383

Query: 494 TFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRM-DPKEKERQRLENLRRKEEAEQLRR 552
             +H  ++ +           + +   ++    +M   +EK R++ E +R +E+    + 
Sbjct: 384 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQE 443

Query: 553 QKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEE 612
           +K+ E ++ R EE + ++EE  R+  + RE+ E  ++++K   ++K  + +EK  + +E+
Sbjct: 444 EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEK 503

Query: 613 RLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLR 672
              +E+  ++   K   + E  R+QEE+ R     +QEE+ R  +E++Q+++E+  E   
Sbjct: 504 MHDQEEKIREQEEKMWRQEEKIREQEEKIR-----EQEEKIREQEEMMQEQEEKMGE--- 555

Query: 673 KAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERE 732
              + +++ EQ +  R+E++ REQE + +E++E+ R ++E+   ++E+ REQE +  E+E
Sbjct: 556 ---QEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQE 612

Query: 733 --LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 774
             + E+E+ +  Q+E++Q + E+ +++EE+    E +L++++EK
Sbjct: 613 EKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 656



 Score =  120 bits (300), Expect = 8e-27
 Identities = 72/260 (27%), Positives = 159/260 (61%), Gaps = 13/260 (5%)

Query: 527 RMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR----KVLQARE 582
           +M  +EK R++ E  + +E+  +  +++ +E K  R EE   ++EE++R    K+ +  E
Sbjct: 385 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEE 444

Query: 583 RV---EQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 639
           ++   E+++EE+K+Q +++  + +EK  + +E    +EK  ++   +K EE   R++++ 
Sbjct: 445 KIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKM 504

Query: 640 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERR 699
             +  +  +QEE+  R +E +++++E+ +E+  K  E + + +++E++  EQE + QE+ 
Sbjct: 505 HDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQE 564

Query: 700 EQERREQERREQERQLAEQ-ERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKE 758
           +  R+E++ REQE ++ EQ E+ REQ     E ++ E+E+ +R Q+E +Q + E+  ++E
Sbjct: 565 KMRRQEEKIREQEEKIREQKEKIREQ-----EEKIWEQEEKIREQEEMMQEQEEKMWEQE 619

Query: 759 EQQRLAERQLQEEQEKKAKE 778
           E+    E ++QE++EK  ++
Sbjct: 620 EKMCEQEEKMQEQEEKMRRQ 639



 Score =  115 bits (288), Expect = 2e-25
 Identities = 86/299 (28%), Positives = 167/299 (55%), Gaps = 38/299 (12%)

Query: 513 RSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKL---- 568
           R  +   + RNT    + KEK  +  E L+  E  +   +  V+E KR+ LE  KL    
Sbjct: 202 RDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRK-LERAKLLLPQ 260

Query: 569 -----------KREERLRKVLQAR-------ERVEQMKEEKKKQIEQKFAQIDEKTEKAK 610
                      K  + +   LQA+        R+ Q +EEK  + E+K  + +EK ++ +
Sbjct: 261 QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQE-Q 319

Query: 611 EERLAEEKAKKKAAAKKMEEVEARRKQEEEARR----LRWLQQEEEERRHQELLQKKKEE 666
           EE++ E++ K +   +KM   E    ++EE  R    + W ++EE+ RR +E++ +K+E+
Sbjct: 320 EEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW-EKEEKMRRLEEMMWEKEEK 378

Query: 667 EQERLRKAAEAKRLAEQREQERREQERREQERREQE-----RREQERREQERQLAEQERR 721
            +E   K  E +++ EQ E+ + E++ REQE+R+++     R+E++ REQE ++ EQE++
Sbjct: 379 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKK 438

Query: 722 --REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
             R++E++  + +++E EK  R ++E++ R+ E+ +++EE  R  E+  ++E+ +K +E
Sbjct: 439 MWRQEEKIHEQEKIREEEK--RQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEE 495



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 75/219 (34%), Positives = 135/219 (61%), Gaps = 26/219 (11%)

Query: 531 KEKERQRLENLRRKEEA----EQLRRQKV---EEDKRRRLEEVKLKREERLR-KVLQARE 582
           +E++RQ  E + R+EE     E++ RQK    E++K R+ EE   ++EE++  +  + RE
Sbjct: 454 EEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIRE 513

Query: 583 RVEQM--KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE 640
           + E+M  +EEK ++ E+K  + +EK  + +EE + E++ K     +KM+E E  R+QEE+
Sbjct: 514 QEEKMWRQEEKIREQEEKIREQEEKIRE-QEEMMQEQEEKMGEQEEKMQEQEKMRRQEEK 572

Query: 641 ARRLRWLQQEEEERRHQELLQKKKE---EEQERLRKAAEAKRLAEQR--EQERR--EQER 693
            R     +QEE+ R  +E +++++E   E++E++R+  E  +  E++  EQE +  EQE 
Sbjct: 573 IR-----EQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 627

Query: 694 REQERREQERREQERR-EQERQLAEQERR--REQERLQA 729
           + QE+ E+ RR++E+  EQE +L +QE +    QE L+A
Sbjct: 628 KMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 666



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 62/206 (30%), Positives = 118/206 (57%), Gaps = 29/206 (14%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERLRKVLQARERVEQMK 588
           KEK  ++ E +R++EE    + +K+  +E+K R  EE   ++EE++      RE+ E+++
Sbjct: 481 KEKMHEQ-EKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKI------REQEEKIR 533

Query: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648
           E+++K  EQ             EE + E++ K     +KM+E E  R+QEE+ R     +
Sbjct: 534 EQEEKIREQ-------------EEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIR-----E 575

Query: 649 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR--EQERREQERREQ 706
           QEE+ R  +E +++++E+  E+  K  E + + +++E++  EQE +  EQE + QE+ E+
Sbjct: 576 QEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 635

Query: 707 ERREQERQLAEQERRREQERLQAERE 732
            RR++E+   ++ R R+QE    E +
Sbjct: 636 MRRQEEKMWEQEVRLRQQEEKMQEHQ 661



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 66/251 (26%), Positives = 134/251 (53%), Gaps = 32/251 (12%)

Query: 531 KEKERQRLENLRRKEEAEQLR--RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK 588
           K+K  + +E L ++ +A  L   R  + +++   L+E   K +E+L+ V   +  ++   
Sbjct: 188 KKKADRYIEELTKERDALSLELYRNTITDEE---LKEKNAKLQEKLQLVESEKSEIQLNV 244

Query: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648
           +E K+++E+    + ++  +A+ + L +E     A      +++A+ ++ E   RL   Q
Sbjct: 245 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA------KLQAQVEENELWNRLNQ-Q 297

Query: 649 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 708
           QEE+  R +E +Q+ +E+ QE+                   E++ REQE + +E+ E+ R
Sbjct: 298 QEEKMWRQEEKIQEWEEKIQEQ-------------------EEKIREQEEKIREQEEKMR 338

Query: 709 REQERQLAEQERRREQERLQAERELQERE-KALRLQKEQLQRELEEKKKKEEQQRLAERQ 767
           R++E    ++E+ R QE +  E+E + R  + +  +KE+  RELEEK  ++E+ R  E +
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEK 398

Query: 768 LQEEQEKKAKE 778
            QEE++ + +E
Sbjct: 399 RQEEEKIREQE 409



 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 70/294 (23%), Positives = 141/294 (47%), Gaps = 45/294 (15%)

Query: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVL-QARERVEQM 587
           D ++   Q  E LRR+ EA Q+   ++   ++  L+      +  ++++  +AR+ + ++
Sbjct: 109 DEQKASHQHQEALRRELEA-QVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 167

Query: 588 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAA------AKKMEEVEARRKQEEEA 641
            +  K   E + A     T+K K +R  EE  K++ A         + + E + K  +  
Sbjct: 168 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 227

Query: 642 RRLRWLQQEEE-------------ERRHQELLQKKKEEEQERLRKAAEA----------- 677
            +L+ ++ E+              ER    L Q++ + E + L K  ++           
Sbjct: 228 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 287

Query: 678 ----KRLAEQREQERREQERREQERREQERREQER-REQERQLAEQER--RREQERLQAE 730
                RL +Q+E++   QE + QE  E+ + ++E+ REQE ++ EQE   RR++E +  +
Sbjct: 288 NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEK 347

Query: 731 RELQEREKALRLQKEQLQRELE------EKKKKEEQQRLAERQLQEEQEKKAKE 778
            E   R++ +  +KE+  R LE      E+K +E ++++ E++   EQE+K +E
Sbjct: 348 EEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE 401



 Score = 70.5 bits (171), Expect = 7e-12
 Identities = 66/249 (26%), Positives = 120/249 (48%), Gaps = 25/249 (10%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
           +QE K  + +  RE  +   ++  ++Q      EE+  E EE+   + K           
Sbjct: 441 RQEEKIHEQEKIREEEKRQEQEEMWRQ------EEKIREQEEIWRQKEKMHEQ------- 487

Query: 489 VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAE 548
              +R     V R +  M          +  + R      + +EK R++ E +R +EE  
Sbjct: 488 -EKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMM 546

Query: 549 QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEK 608
           Q + +K+ E + +  E+ K++R+E      + RE+ E+++E+K+K  EQ+  +I E+ EK
Sbjct: 547 QEQEEKMGEQEEKMQEQEKMRRQEE-----KIREQEEKIREQKEKIREQE-EKIWEQEEK 600

Query: 609 AK--EERLAEEKAKKKAAAKKM-EEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKE 665
            +  EE + E++ K     +KM E+ E  ++QEE+ RR      E+E R  Q+  ++K +
Sbjct: 601 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ--EEKMQ 658

Query: 666 EEQERLRKA 674
           E QE L  A
Sbjct: 659 EHQEHLEAA 667


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score =  131 bits (330), Expect = 3e-30
 Identities = 87/266 (32%), Positives = 170/266 (63%), Gaps = 25/266 (9%)

Query: 529 DPKEKERQRLENLRRKEEA-----EQLRRQKV----EEDKRRRLEEVKLKREERLRKVLQ 579
           + +EK R++ E +RR+EE      E++RRQ+     +E+K R LEE K+  +E++R+  +
Sbjct: 306 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE-KMHEQEKIREQEE 364

Query: 580 ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 639
            R+  E+++E++K+Q ++      E+  + +EE++ E++   +   +KM E E +  ++E
Sbjct: 365 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQE 424

Query: 640 EARRLRWLQQEEEERRHQELL---QKKKEEEQERLRKAAEAKRLAEQR--EQERR--EQE 692
           E  +    +QEE+ RR +E +   +KK  E++E++R+  E  +  E++  EQE +  EQE
Sbjct: 425 EEMQ----EQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQE 480

Query: 693 RREQERREQERREQER-REQERQLAEQERR-REQERLQAERE--LQEREKALRLQKEQLQ 748
            + QE+ E+ RR++E+ REQE+++ EQE + REQE +  E+E  + E+E+ +  Q+E++Q
Sbjct: 481 AKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ 540

Query: 749 RELEEKKKKEEQQRLAERQLQEEQEK 774
            + E+ +++EE+ R  E +L++++EK
Sbjct: 541 EQEEKMRRQEEKMREQEVRLRQQEEK 566



 Score =  129 bits (324), Expect = 1e-29
 Identities = 82/255 (32%), Positives = 162/255 (63%), Gaps = 18/255 (7%)

Query: 526 LRMDPKEKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERLRKVLQARER 583
           L    +EK  ++ E ++ +EE  Q + +K+  +E+K RR EE+  ++EE++R+    +E 
Sbjct: 282 LNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRR----QEE 337

Query: 584 VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 643
           +   KEEK +++E+K  +  EK  + +E+R  EEK +++   +K +E EA+  ++EE  R
Sbjct: 338 MMWEKEEKIRELEEKMHE-QEKIREQEEKRQEEEKIREQ---EKRQEQEAKMWRQEEKIR 393

Query: 644 LRWLQQEEEERRHQELLQKKKEEEQERLRKAAE-AKRLAEQREQERREQER-REQERREQ 701
               +QEE+ R  +E++Q+++E+  E+  K  E  + + EQ E+ RR++E+ REQE++ +
Sbjct: 394 ----EQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIR 449

Query: 702 ERREQERREQERQLAEQERRREQERLQAERE--LQEREKALRLQKEQLQRELEEKKKKEE 759
           E+ E+ R ++E    ++E+  EQE    E+E  +QE+E+ +R Q+E+++ + ++ +++EE
Sbjct: 450 EQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEE 509

Query: 760 QQRLAERQLQEEQEK 774
           + R  E  +QE++EK
Sbjct: 510 KIREQEEMMQEQEEK 524



 Score =  118 bits (295), Expect = 3e-26
 Identities = 74/257 (28%), Positives = 161/257 (62%), Gaps = 11/257 (4%)

Query: 520 IKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQ 579
           ++R   +  + +EK R++ E +  KEE  +   +K+ E ++ R +E K + EE++R+  +
Sbjct: 318 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 377

Query: 580 ARERVEQM--KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR-RK 636
            +E+  +M  +EEK ++ E+K  + +E  ++ +EE++ E++ K     ++M+E E + R+
Sbjct: 378 RQEQEAKMWRQEEKIREQEEKIREQEEMMQE-QEEKMGEQEEKMWEQEEEMQEQEEKMRR 436

Query: 637 QEEEARRL--RWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 694
           QEE+ R    +  +QEE+ R  +E++Q+++E+  E+  K  E     E + QE+ E+ RR
Sbjct: 437 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQ----EAKMQEQEEKMRR 492

Query: 695 EQER-REQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 753
           ++E+ REQE++ +E+ E+ R+  E  + +E++  + E ++ E+E+ ++ Q+E+++R+ E+
Sbjct: 493 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 552

Query: 754 KKKKEEQQRLAERQLQE 770
            +++E + R  E ++QE
Sbjct: 553 MREQEVRLRQQEEKMQE 569



 Score =  117 bits (293), Expect = 5e-26
 Identities = 84/293 (28%), Positives = 165/293 (56%), Gaps = 32/293 (10%)

Query: 513 RSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 572
           R  +   + RNT    + KEK  +  E L+  E  +   +  V+E KR      KL+R +
Sbjct: 190 RDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKR------KLERAK 243

Query: 573 RLRKVLQARERVEQMKEEKKKQIEQKFAQIDE-----KTEKAKEERLAEEKAKKKAAAKK 627
            L    Q +   + + +E +    +  AQ++E     +  + +EE++  ++ K +   +K
Sbjct: 244 LLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEK 303

Query: 628 MEEVEAR-RKQEEEARRLRWLQQEEEE--RRHQELLQKKKEEEQERLRKAAEAKRLAEQR 684
           ++E E + R+QEE+ RR   +  E+EE  RR +E++ +K+E+ +E   K  E +++ EQ 
Sbjct: 304 IQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE 363

Query: 685 EQERREQERREQERREQE-----RREQERREQERQLAEQER----------RREQERLQA 729
           E+ + E++ REQE+R+++     R+E++ REQE ++ EQE            +E++  + 
Sbjct: 364 EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQ 423

Query: 730 ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAER-QLQEEQEKKAKEAAG 781
           E E+QE+E+ +R Q+E+++ +  EKK +E+++++ E+ ++ +EQE+K  E  G
Sbjct: 424 EEEMQEQEEKMRRQEEKIREQ--EKKIREQEEKIREQEEMMQEQEEKMGEQEG 474



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 60/251 (23%), Positives = 138/251 (54%), Gaps = 7/251 (2%)

Query: 531 KEKERQRLENLRRKEEAEQLR--RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK 588
           K+K  + +E L ++ +A  L   R  + +++   L+E   K +E+L+ V   +  ++   
Sbjct: 176 KKKADRYIEELTKERDALSLELYRNTITDEE---LKEKNAKLQEKLQLVESEKSEIQLNV 232

Query: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK-KMEEVEARRKQEEEARRLRWL 647
           +E K+++E+    + ++  +A+ + L +E     A  + ++EE E   +  ++     W 
Sbjct: 233 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWR 292

Query: 648 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 707
           Q+E+ + R +E +Q+++E+ +E+  K    + +  ++E++ R QE    E+ E+ R  +E
Sbjct: 293 QEEKIQER-EEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 351

Query: 708 RREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ 767
           +  ++ ++ EQE +R++E    E+E ++ ++A   ++E+  RE EEK +++E+    + +
Sbjct: 352 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEE 411

Query: 768 LQEEQEKKAKE 778
              EQE+K  E
Sbjct: 412 KMGEQEEKMWE 422



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 61/276 (22%), Positives = 133/276 (48%), Gaps = 30/276 (10%)

Query: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVL-QARERVEQM 587
           D ++   Q  E LRR+ EA Q++  ++   ++  L+      +  ++++  +AR+ + ++
Sbjct: 97  DEQKASHQHQEALRRELEA-QVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 155

Query: 588 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK------KMEEVEARRKQEEEA 641
            +  K   E + A     T+K K +R  EE  K++ A         + + E + K  +  
Sbjct: 156 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 215

Query: 642 RRLRWLQQEEEE-------------RRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER 688
            +L+ ++ E+ E             R    L Q++ + E + L K  ++     Q + E 
Sbjct: 216 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 275

Query: 689 REQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQ 748
            E   R  +++E++   QE + QER   E++ + ++E+++ + E   R++ +  +KE+  
Sbjct: 276 NELWNRLNQQQEEKMWRQEEKIQER---EEKIQEQEEKIREQEEKMRRQEEMMWEKEEKM 332

Query: 749 RELE------EKKKKEEQQRLAERQLQEEQEKKAKE 778
           R  E      E+K +E ++++ E++   EQE+K +E
Sbjct: 333 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE 368


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score =  129 bits (323), Expect = 2e-29
 Identities = 87/280 (31%), Positives = 163/280 (58%), Gaps = 33/280 (11%)

Query: 529 DPKEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQ 586
           + +EK R++ E + R+EE   EQ ++ + +E K R  EE   +++ERLR+  +     E+
Sbjct: 359 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK 418

Query: 587 MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR- 645
           M E+ +K  E+K  Q  EK  + +EE++ EE+  ++   K  EE E  R+QEE+ ++   
Sbjct: 419 MWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEE 478

Query: 646 --WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER--------RE 695
             W Q+E+E ++ +   QK+K  EQE++++  E  ++ EQ E+ R ++E         R+
Sbjct: 479 NMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE--KIWEQEEKIRDQEEMWGQEKKMWRQ 536

Query: 696 QERREQE----RREQERREQERQLAEQERRRE-------------QERLQAERELQEREK 738
           ++ REQE     +E++ R+QE+++ +QE R E             +E+++ E  ++EREK
Sbjct: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596

Query: 739 ALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
            +R ++E++ RE EEK +++E++   + +   EQE+K +E
Sbjct: 597 KMR-EEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQE 635



 Score =  125 bits (314), Expect = 2e-28
 Identities = 82/269 (30%), Positives = 163/269 (60%), Gaps = 22/269 (8%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERL-RKVLQARERVEQM 587
           +EKE +  + LR +EE  Q + +K+  +E+K R  EE   ++EERL  +  Q RE+ ++M
Sbjct: 333 QEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKM 392

Query: 588 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA------ 641
           ++++++  EQ   ++ EK E+ +E+    E+ +K    KKM+E E + + +EE       
Sbjct: 393 RDQEERMWEQD-ERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEER 451

Query: 642 --RRLRWLQQEEEERRHQ-ELLQKKKEEEQERLRKAAEAKRLAEQRE-----QERREQER 693
              R + +++EEE  R Q E +QK++E   E+  K  + +RL EQ+E     ++ +EQE 
Sbjct: 452 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE 511

Query: 694 REQERREQERREQERREQERQLAEQERRREQE--RLQAERELQEREKALRLQKEQLQREL 751
           +  E+ E+ R ++E   QE+++  QE+ REQE    + E +++++E+ +  Q+E+++++ 
Sbjct: 512 KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKT 571

Query: 752 EEKKKK--EEQQRLAERQLQEEQEKKAKE 778
           +E++KK  ++++++ E +   E+EKK +E
Sbjct: 572 QEQEKKTWDQEEKMREEERMREREKKMRE 600



 Score =  122 bits (306), Expect = 2e-27
 Identities = 112/440 (25%), Positives = 217/440 (49%), Gaps = 50/440 (11%)

Query: 369 QKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAG 428
           QK   EQ+E  +E E     + E         W   +          +      E     
Sbjct: 340 QKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEER-----LWEQEKQMREQEQKMRD 394

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
           Q+E   +Q +  RE  +  R +    + V ++ EE+ ++++E    +++         + 
Sbjct: 395 QEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQE---KKTRDQEEKMQEEER 451

Query: 489 VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPL-RMDPKEKERQRLENLRRK--- 544
           +R         +R + +       R   +   K+   +   + KE ++QRL   + K   
Sbjct: 452 IR---------EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 502

Query: 545 EEAEQLRRQKV-EEDKRRRLEEVKLKREERLRKVLQARERVEQM--KEEKKKQIEQKFAQ 601
           +E  Q + +K+ E++++ R +E    +E+++ +  + RE+ +QM  +EEK +  EQK   
Sbjct: 503 QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWD 562

Query: 602 IDEKTEKA----------KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 651
            +E+ EK           +EE++ EE+  ++   K  EE E  R+QEE+ +      QE+
Sbjct: 563 QEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 622

Query: 652 EER--RHQELLQKKKE---EEQERL----RKAAEAKRLAEQREQERREQERREQER-REQ 701
           EE+    +E +Q+++E   E++E++     K  E +RL EQ+E+    ++ +EQE+ +EQ
Sbjct: 623 EEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQ 682

Query: 702 ERREQERREQERQLAEQERRR-EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 760
           E +  E+ + E++  EQE++  +QE+++ E  ++EREK +R ++E++ RE EEK   +EQ
Sbjct: 683 EEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMR-EEEEMMREQEEKM--QEQ 739

Query: 761 QRLAERQLQE--EQEKKAKE 778
           +   + Q +E  EQE+K  E
Sbjct: 740 EEKMQEQEEEMWEQEEKMWE 759



 Score =  117 bits (292), Expect = 6e-26
 Identities = 97/344 (28%), Positives = 192/344 (55%), Gaps = 41/344 (11%)

Query: 461 DEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFI 520
           +EE   ++ ELQ    K P +    S++   ++     ++R + L+ P     ++ +   
Sbjct: 220 NEELKKKNAELQ---EKLPLAESEKSEIQLNVKELKRKLERAKFLL-PQVQTNTLQEEMW 275

Query: 521 KRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEE--------DKRRRLEEVKLKREE 572
           ++   LR + ++K R++ E + R+EE  + +  K+ E        +KR R +E +L+ +E
Sbjct: 276 RQEEELR-EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQE 334

Query: 573 R-LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKA--KEERLAEEKAKKKAAAKKME 629
           + LR+  + RE+ EQM+E+++K  EQ+  ++ E+ EK   +EERL E++ + +   +KM 
Sbjct: 335 KELREQKELREQEEQMQEQEEKMWEQE-EKMREQEEKMWRQEERLWEQEKQMREQEQKMR 393

Query: 630 EVEARRKQEEEARRLRWLQQEEEERRHQE--------LLQKKKEEEQERLRKAAEAKRLA 681
           + E R  +++E      L+++EE  R QE        + ++KK +EQE+  +  E K   
Sbjct: 394 DQEERMWEQDER-----LREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQE 448

Query: 682 EQREQERREQERREQE-RREQERREQERRE-----QERQLAEQERRREQERLQAERELQE 735
           E+R +ER ++ R E+E  REQE + Q++ E     +E++  +Q    ++E+L  + ++QE
Sbjct: 449 EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE 508

Query: 736 REKALRLQKEQL--QREL---EEKKKKEEQQRLAERQLQEEQEK 774
           +E+ +  Q+E++  Q E+   E+K  ++E+ R  E Q+ E++EK
Sbjct: 509 QEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 552



 Score =  114 bits (285), Expect = 4e-25
 Identities = 73/255 (28%), Positives = 152/255 (59%), Gaps = 21/255 (8%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
           +E+ER R    + +EE E +R Q   E+K +  EE   ++EE++       E+ E+M+E+
Sbjct: 586 REEERMREREKKMREEEEMMREQ---EEKMQEQEEKMQEQEEKMW------EQEEKMQEQ 636

Query: 591 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE---EARRLRWL 647
           ++K  EQ+    +++ +  +++RL E+K +K    +KM+E E  ++QEE   E  ++   
Sbjct: 637 EEKMWEQEEKMWEQEEKMWEQQRLPEQK-EKLWEHEKMQEQEKMQEQEEKIWEQEKMEKK 695

Query: 648 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 707
            QE+E++   +   +++E  +ER +K  E + +  ++E++ +EQE + QE+ E+   ++E
Sbjct: 696 TQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEE 755

Query: 708 RR-EQERQLAEQERRREQ-------ERLQAERELQEREKALRLQKEQLQRELEEKKKKEE 759
           +  EQE ++ EQ+R  EQ       E++Q + ++ E+E+ +R Q+E+++ + E+ + +EE
Sbjct: 756 KMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEE 815

Query: 760 QQRLAERQLQEEQEK 774
           + R  E ++  ++EK
Sbjct: 816 KMRGQEEKMWGQEEK 830



 Score =  112 bits (279), Expect = 2e-24
 Identities = 74/260 (28%), Positives = 159/260 (61%), Gaps = 21/260 (8%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
           +++E+ R +  +  ++ E++ ++  E++K+   +E K++ EER+R+    RE+  + +EE
Sbjct: 548 EQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRE----REKKMREEEE 603

Query: 591 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 650
             ++ E+K  + +EK ++ +EE++ E++ K +   +KM E E +  ++EE     W QQ 
Sbjct: 604 MMREQEEKMQEQEEKMQE-QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEK---MWEQQR 659

Query: 651 EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR----EQERREQERREQ 706
             E++ ++L + +K +EQE++++  E     E+ E++ +EQE++    E+ R E+  RE+
Sbjct: 660 LPEQK-EKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRER 718

Query: 707 ER--REQERQLAEQERR---REQERLQAERELQEREKALRLQKEQL---QRELEEKKKKE 758
           E+  RE+E  + EQE +   +E++  + E E+ E+E+ +  Q+E++   QR  E+K+K  
Sbjct: 719 EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 778

Query: 759 EQQRLAERQLQEEQEKKAKE 778
           E +++ E++   EQE+K ++
Sbjct: 779 EHEKMQEQEKIWEQEEKMRD 798



 Score =  112 bits (279), Expect = 2e-24
 Identities = 71/256 (27%), Positives = 148/256 (57%), Gaps = 10/256 (3%)

Query: 527 RMDPKEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR-ER 583
           +M  +E+ R+R + +R +EE   EQ  + + +E+K +  EE   ++EE++++  +   E+
Sbjct: 584 KMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQ 643

Query: 584 VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 643
            E+M E+++K  EQ+  ++ E+ EK  E    +E+ K +   +K+ E E   K+ +E  +
Sbjct: 644 EEKMWEQEEKMWEQQ--RLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEK 701

Query: 644 LRWLQQEEEERRHQELLQKKKEEEQERLR----KAAEAKRLAEQREQERREQERREQERR 699
             W Q++  E       +KK  EE+E +R    K  E +   +++E+E  EQE +  E+ 
Sbjct: 702 KTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQE 761

Query: 700 EQERREQERREQERQLAEQERRREQERL-QAERELQEREKALRLQKEQLQRELEEKKKKE 758
           E+   +Q   EQ+ +L E E+ +EQE++ + E +++++E+ +R Q+E+++ + E+ + +E
Sbjct: 762 EKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQE 821

Query: 759 EQQRLAERQLQEEQEK 774
           E+    E ++  ++EK
Sbjct: 822 EKMWGQEEKMWGQEEK 837



 Score =  104 bits (259), Expect = 4e-22
 Identities = 76/272 (27%), Positives = 154/272 (56%), Gaps = 29/272 (10%)

Query: 513 RSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 572
           R  +   + RNT    + K+K  +  E L   E  +   +  V+E KR      KL+R +
Sbjct: 206 RDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKR------KLERAK 259

Query: 573 RLRKVLQARERVEQM--KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEE 630
            L   +Q     E+M  +EE+ ++ E+K  + +EK  + +EERL E++ K +   +KM  
Sbjct: 260 FLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR-QEERLREQEGKMREQEEKMWR 318

Query: 631 VEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAK-RLAEQREQERR 689
            E R +++E+      L+++E+E R Q+ L++++E+ QE+  K  E + ++ EQ E+  R
Sbjct: 319 QEKRLREQEKE-----LREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWR 373

Query: 690 EQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQK---EQ 746
           ++ER  ++ ++   +EQ+ R+QE ++ EQ+ R           L+E+E+ +R Q+   EQ
Sbjct: 374 QEERLWEQEKQMREQEQKMRDQEERMWEQDER-----------LREKEERMREQEKMWEQ 422

Query: 747 LQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
           +++  EEKK +E++++  +++ + ++E++ +E
Sbjct: 423 VEKMREEKKMQEQEKKTRDQEEKMQEEERIRE 454



 Score =  102 bits (254), Expect = 2e-21
 Identities = 102/497 (20%), Positives = 227/497 (45%), Gaps = 57/497 (11%)

Query: 318 LAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKE 377
           L +K   + +QE +  +  +   +K  +E     R       ++   ++  +++   +K+
Sbjct: 406 LREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR-------DQEEKMQEEERIREREKK 458

Query: 378 PPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQA 437
             EE E +   E ++ +    N W   + E        +      +     Q+E   +Q 
Sbjct: 459 MREEEETMREQEEKMQKQE-ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE 517

Query: 438 DGPREPPQS-ARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFL 496
           +  R+  +   + K+ ++Q      E+Q  E EE    R +         ++ +  +   
Sbjct: 518 EKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKM--RDQEQKMWDQEERMEKKTQEQE 575

Query: 497 HTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEA--EQLRRQK 554
                 +  M      R   K   +    +R + +EK +++ E ++ +EE   EQ  + +
Sbjct: 576 KKTWDQEEKMREEERMREREKKMREEEEMMR-EQEEKMQEQEEKMQEQEEKMWEQEEKMQ 634

Query: 555 VEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKT-EKAKEER 613
            +E+K    EE   ++EE++ +  +  E+ E++ E +K Q ++K  + +EK  E+ K E+
Sbjct: 635 EQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEK 694

Query: 614 LAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ----- 668
             +E+ KK    +KM E E+ R++E++ R    + +E+EE+  ++  + +++EE+     
Sbjct: 695 KTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQE 754

Query: 669 ----ERLRKAAEAKRLAEQREQERREQERREQER---REQERREQE---RREQERQLAEQ 718
               E+  K  E +RL EQ+E+    ++ +EQE+   +E++ R+QE   R ++E+   ++
Sbjct: 755 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQE 814

Query: 719 ERRREQERL---------------------------QAERELQEREKALRLQKEQLQREL 751
           E+ R QE                             + E ++Q +E+ +R Q+E+++ + 
Sbjct: 815 EKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQE 874

Query: 752 EEKKKKEEQQRLAERQL 768
           E+ +++EE+ R  E ++
Sbjct: 875 EKMREQEEKMRGQEEKI 891



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 82/371 (22%), Positives = 179/371 (48%), Gaps = 55/371 (14%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
           +QE K    +      +    K++ +Q     D+E+ + +EE    R K           
Sbjct: 548 EQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKK---------- 597

Query: 489 VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAE 548
                     ++  + +M          +  ++       + +EK +++ E +  +EE  
Sbjct: 598 ----------MREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKM 647

Query: 549 QLRRQKVEEDKRRRLEEVKLKREERLR---KVLQARERV-EQMKEEKKKQIEQKFAQIDE 604
             + +K+ E +R   ++ KL   E+++   K+ +  E++ EQ K EKK Q ++K      
Sbjct: 648 WEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEK------ 701

Query: 605 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK 664
             +   +E++ EE++ ++   K  EE E  R+QEE+ +     +QEE+ +  +E + +++
Sbjct: 702 --KTWDQEKMREEESMREREKKMREEEEMMREQEEKMQ-----EQEEKMQEQEEEMWEQE 754

Query: 665 EEEQERLRKAAEAKRLAEQRE-----QERREQER-REQERREQERREQERREQERQLAEQ 718
           E+  E+  K  E +RL EQ+E     ++ +EQE+  EQE + +++ E+ R ++E+   ++
Sbjct: 755 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQE 814

Query: 719 ERRREQERLQ---------AERELQEREKALRLQKEQLQREL---EEKKKKEEQQRLAER 766
           E+ R QE             E ++  +E+ +  Q+E+++ ++   EEK +++E++   + 
Sbjct: 815 EKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQE 874

Query: 767 QLQEEQEKKAK 777
           +   EQE+K +
Sbjct: 875 EKMREQEEKMR 885



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 54/181 (29%), Positives = 98/181 (54%), Gaps = 11/181 (6%)

Query: 606 TEKAKEERLAEEKAKKKAAAK------KMEEVEARRKQEEEARRLRWLQQEEEERRHQEL 659
           T   K +R  EE  K++ A         +   E ++K  E   +L   + E+ E +    
Sbjct: 190 TRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVK 249

Query: 660 LQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQE 719
             K+K E  + L    +   L  Q E  R+E+E REQE++ +++ E+  R++ER   ++ 
Sbjct: 250 ELKRKLERAKFLLPQVQTNTL--QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEG 307

Query: 720 RRREQERL--QAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 777
           + REQE    + E+ L+E+EK LR Q+++L RE +E +++EEQ +  E ++ E++EK  +
Sbjct: 308 KMREQEEKMWRQEKRLREQEKELREQEKEL-REQKELREQEEQMQEQEEKMWEQEEKMRE 366

Query: 778 E 778
           +
Sbjct: 367 Q 367


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score =  128 bits (322), Expect = 2e-29
 Identities = 93/290 (32%), Positives = 171/290 (58%), Gaps = 44/290 (15%)

Query: 529 DPKEKERQRLENLRRKEEA-----EQLRRQKV----EEDKRRRLEEVKLKREERLRKVLQ 579
           + +EK R++ E +RR+EE      E++RRQ+     +E+K RR EE+  ++EE++R+   
Sbjct: 325 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR--- 381

Query: 580 ARERVEQMKEEKKKQIEQKFAQ---IDEKTEKAKEE-RLAEEKAKKKAAAKKMEEVEARR 635
            +E +   KEEK +++E+K  +   I E+ EK +EE ++ E++ +++  AK   + E  R
Sbjct: 382 -QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 440

Query: 636 KQEEEAR---RLRWLQQE----------EEERRHQELLQKKKEEEQERLRKAAEAKRLAE 682
           +QEE+ R   +  W Q+E          EE+R+ QE + +++E+  E+     + +++ E
Sbjct: 441 EQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHE 500

Query: 683 QREQERREQER--------REQER--REQE----RREQERREQERQLAEQERRREQERLQ 728
           Q E+ R+++E+        REQE   REQE    R+E++ REQE    E+E+  EQE++ 
Sbjct: 501 QEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIW 560

Query: 729 AERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
            E + QE+E  +  Q+E+++ + E+  ++EE+ R  E + QE++EK  K+
Sbjct: 561 EEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610



 Score =  124 bits (312), Expect = 3e-28
 Identities = 79/257 (30%), Positives = 161/257 (62%), Gaps = 18/257 (7%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERLRKVLQARERVEQMK 588
           KEK  ++ E +R++EE    + +K+  +E+K R  EE   ++EE++R+  +     E+M 
Sbjct: 495 KEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMH 554

Query: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648
           E++K   E+K  + ++K  + +EE++ E++ K     +K+ E E +R+++EE    +  +
Sbjct: 555 EQEKIWEEEKRQEQEDKMWR-QEEKIREQEEKVWRQEEKIREQEEKRQEQEE----KMWK 609

Query: 649 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR--EQERREQE---- 702
           QEE+ R  +E +Q+++E+ +E+  K  E + + +++E++  EQE +  EQE + QE    
Sbjct: 610 QEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEET 669

Query: 703 --RREQERREQERQLAEQERR-REQERLQAERE--LQEREKALRLQKEQLQRELEEKKKK 757
             R+E++ REQE+++ EQE + REQE +  E+E  + E+E+ +  Q+E++Q + E+ +++
Sbjct: 670 MWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 729

Query: 758 EEQQRLAERQLQEEQEK 774
           EE+    E +L++++EK
Sbjct: 730 EEKMWEQEVRLRQQEEK 746



 Score =  118 bits (296), Expect = 2e-26
 Identities = 92/318 (28%), Positives = 179/318 (56%), Gaps = 61/318 (19%)

Query: 520 IKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKV----EEDKRRRLEEVKLKREERLR 575
           ++R   +  + +EK R++ E +  KEE  ++RRQ+     +E+K RR EE+  ++EE++R
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEKEE--KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 394

Query: 576 KVLQARERVEQMKE-EKKKQIEQKFAQIDEKTEKA-----KEERLAEEKAKKKAAAKKM- 628
           ++ +     E+++E E+K+Q E+K  + +++ E+      +EE++ E++ K +   KKM 
Sbjct: 395 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMW 454

Query: 629 ------------EEVEARRKQEEEARRLR--------WLQ------QEEEERRHQELLQK 662
                        E E R++QEE  R+          W Q      QEE+ R+ +E + +
Sbjct: 455 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWR 514

Query: 663 KKE---EEQERLRKAAE-----AKRLAEQREQERREQERREQE-------RREQE----R 703
           ++E   E++E++R+  E      +++ EQ E  R E++  EQE       R+EQE    R
Sbjct: 515 QEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWR 574

Query: 704 REQERREQERQLAEQE---RRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 760
           +E++ REQE ++  QE   R +E++R + E ++ ++E+ +R Q+E++Q + E+ +++EE+
Sbjct: 575 QEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEK 634

Query: 761 QRLAERQLQEEQEKKAKE 778
            R  E   QE++EK  ++
Sbjct: 635 IREQEEMTQEQEEKMGEQ 652



 Score =  116 bits (290), Expect = 1e-25
 Identities = 79/263 (30%), Positives = 161/263 (61%), Gaps = 16/263 (6%)

Query: 531 KEKERQRLENLRRKEEA----EQLRRQKV----EEDKRRRLEEVKLKREERLRKVLQA-R 581
           +E++RQ  E + R+EE     E++ RQK     +E+K R+ EE   ++EE++R+  +  R
Sbjct: 468 EEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIR 527

Query: 582 ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA 641
           E+ E+M  +++K  EQ+    +E+ +  ++E++ EE+ +++   K   + E  R+QEE+ 
Sbjct: 528 EQEEKMWRQEEKIREQEEMWREEE-KMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKV 586

Query: 642 RRLRWLQQEEEERR--HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERR 699
            R     +E+EE+R   +E + K++E+ +E+  K  E +    ++E++ REQE   QE+ 
Sbjct: 587 WRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQE 646

Query: 700 EQERREQERR-EQERQLAEQER---RREQERLQAERELQEREKALRLQKEQLQRELEEKK 755
           E+   ++E+  EQE ++ EQE    R+E++  + E++++E+E+ +R Q+E +Q + E+  
Sbjct: 647 EKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 706

Query: 756 KKEEQQRLAERQLQEEQEKKAKE 778
           ++EE+    E ++QE++EK  ++
Sbjct: 707 EQEEKMCEQEEKMQEQEEKMRRQ 729



 Score =  113 bits (283), Expect = 7e-25
 Identities = 112/492 (22%), Positives = 237/492 (48%), Gaps = 62/492 (12%)

Query: 318 LAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKE 377
           L +K  LV  ++S ++   + L +K                LER   +   Q++ +E   
Sbjct: 226 LQEKLQLVESEKSEIQLNVKELKRK----------------LERAKLLLPQQQLQAEADH 269

Query: 378 PPEEAEPVAAA-EPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQ 436
             +E + V+A  + +V EN     W   + +        +      E     Q+E   +Q
Sbjct: 270 LGKELQSVSAKLQAQVEENE---LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ 326

Query: 437 ADGPREPPQSARRK-----------RSYKQAVSELDEEQHLEDE---ELQPPRSKTPSSP 482
            +  RE  +  RR+           R  ++ + E +E+   ++E   E +    +     
Sbjct: 327 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM 386

Query: 483 CPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRM-DPKEKERQRLENL 541
               + +R L   +H  ++ +           + +   ++    +M   +EK R++ E +
Sbjct: 387 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 446

Query: 542 RRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKE-EKKKQIEQKFA 600
           R +E+    + +K+ E ++ R EE + ++EE  R+  +  E+ E  ++ EK  + E+K  
Sbjct: 447 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIR 506

Query: 601 QIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQE-- 658
           + +EK  + +EE++ E++ K +   +KM   E + +++EE  R       EEE+ H++  
Sbjct: 507 KQEEKVWR-QEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR-------EEEKMHEQEK 558

Query: 659 -LLQKKKEEEQERLRKAAEAKRLAEQR----EQERREQERREQERREQERREQER-REQE 712
              ++K++E+++++ +  E  R  E++    E++ REQE + QE+ E+  +++E+ REQE
Sbjct: 559 IWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQE 618

Query: 713 RQLAEQERR--------REQERLQAERE--LQEREKALRLQKEQLQRELEEKKKKEEQQR 762
            ++ EQE +        REQE +  E+E  + E+E+ +  Q+E++Q + E   ++EE+ R
Sbjct: 619 EKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIR 678

Query: 763 LAERQLQEEQEK 774
             E++++E++EK
Sbjct: 679 EQEKKIREQEEK 690



 Score =  105 bits (262), Expect = 2e-22
 Identities = 73/239 (30%), Positives = 141/239 (58%), Gaps = 17/239 (7%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQM--K 588
           +EK R++ E +R +EE    + +K+ E +    EE K+  +E++ +  + +E+ ++M  +
Sbjct: 516 EEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQ 575

Query: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648
           EEK ++ E+K  + +EK  + +E+R  +E+   K   K  E+ E  ++QEE+ R     +
Sbjct: 576 EEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIR-----E 630

Query: 649 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE--RREQERREQER--REQER- 703
           QEE+ R  +E+ Q+++E+  E+  K  E +   +++E+   R+E++ REQE+  REQE  
Sbjct: 631 QEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEK 690

Query: 704 -REQER--REQERQLAEQERR--REQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
            REQE   +EQE ++ EQE +   ++E++Q + E   R++    ++E   R+ EEK ++
Sbjct: 691 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749



 Score = 96.7 bits (239), Expect = 9e-20
 Identities = 75/280 (26%), Positives = 152/280 (54%), Gaps = 26/280 (9%)

Query: 513 RSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 572
           R  +   + RNT    + KEK  +  E L+  E  +   +  V+E KR      KL+R +
Sbjct: 202 RDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKR------KLERAK 255

Query: 573 RLRKVLQARERVEQMKEEKKKQIEQKFAQIDE-----KTEKAKEERLAEEKAKKKAAAKK 627
            L    Q +   + + +E +    +  AQ++E     +  + +EE++  ++ K +   +K
Sbjct: 256 LLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEK 315

Query: 628 MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE----EQERLRKAAEAKRLAEQ 683
           ++E E + +++EE      ++++EE+ R QE +  +KEE    ++E + +  E  R  E+
Sbjct: 316 IQEQEEKIREQEEK-----IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 370

Query: 684 REQERREQERREQE---RREQERREQERR--EQERQLAEQERRREQERLQAERELQEREK 738
              E+ E+ RR++E    +E++ RE E +  EQE+   ++E+R+E+E+++ + + QE+E 
Sbjct: 371 MMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 430

Query: 739 ALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
            +  Q+E++ RE EEK +++E++   + +   EQEK  +E
Sbjct: 431 KMWRQEEKI-REQEEKIREQEKKMWRQEEKIHEQEKIREE 469



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 72/264 (27%), Positives = 145/264 (54%), Gaps = 26/264 (9%)

Query: 531 KEKERQRLENLRRKEEAEQLR--RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK 588
           K+K  + +E L ++ +A  L   R  + +++   L+E   K +E+L+ V   +  ++   
Sbjct: 188 KKKADRYIEELTKERDALSLELYRNTITDEE---LKEKNAKLQEKLQLVESEKSEIQLNV 244

Query: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648
           +E K+++E+    + ++  +A+ + L +E     A      +++A+ ++ E   RL   Q
Sbjct: 245 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA------KLQAQVEENELWNRLNQ-Q 297

Query: 649 QEEEERRHQELLQKKKEEEQERLRKAAEAK-RLAEQREQERREQE--------RREQERR 699
           QEE+  R +E +Q+ +E+ QE+  K  E + ++ EQ E+ RR++E         R QE  
Sbjct: 298 QEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM 357

Query: 700 EQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEE 759
             E+ E+ RR++E    ++E+ R QE +  E+E + RE   ++ +++  RE EEK+++EE
Sbjct: 358 MWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE 417

Query: 760 QQRLAERQLQEE-----QEKKAKE 778
           + R  E++ ++E     QE+K +E
Sbjct: 418 KIREQEKRQEQEAKMWRQEEKIRE 441



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 61/201 (30%), Positives = 120/201 (59%), Gaps = 19/201 (9%)

Query: 527 RMDPKEKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERLRKVLQARERV 584
           R + ++K  ++ E +R +EE    + +K+  +E+KR+  EE   K+EE++R+    +E  
Sbjct: 565 RQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIRE----QEEK 620

Query: 585 EQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 644
            Q +EEK ++ E+K  + +E T++ +EE++ E++ K     +KM+E E    ++EE  R 
Sbjct: 621 IQEQEEKIREQEEKIREQEEMTQE-QEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIR- 678

Query: 645 RWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR 704
              +QE++ R  +E +++++E  QE+  K  E       +E++  EQE + QE+ E+ RR
Sbjct: 679 ---EQEKKIREQEEKIREQEEMMQEQEEKMWE-------QEEKMCEQEEKMQEQEEKMRR 728

Query: 705 EQERR-EQERQLAEQERRREQ 724
           ++E+  EQE +L +QE + ++
Sbjct: 729 QEEKMWEQEVRLRQQEEKMQE 749



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 67/281 (23%), Positives = 135/281 (48%), Gaps = 38/281 (13%)

Query: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVL-QARERVEQM 587
           D ++   Q  E LRR+ EA Q+   ++   ++  L+      +  ++++  +AR+ + ++
Sbjct: 109 DEQKASHQHQEALRRELEA-QVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 167

Query: 588 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK------KMEEVEARRKQEEEA 641
            +  K   E + A     T+K K +R  EE  K++ A         + + E + K  +  
Sbjct: 168 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 227

Query: 642 RRLRWLQQEEEE-------------RRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER 688
            +L+ ++ E+ E             R    L Q++ + E + L K  ++     Q + E 
Sbjct: 228 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 287

Query: 689 REQERREQERREQE--RREQERREQERQLAEQERR-REQERLQAERELQEREKALRLQKE 745
            E   R  +++E++  R+E++ +E E ++ EQE + REQE      +++E+E+ +R Q+E
Sbjct: 288 NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE-----KIREQEEKMRRQEE 342

Query: 746 QLQRELEEKKK--------KEEQQRLAERQLQEEQEKKAKE 778
            +  E EEK +        KEE+ R  E  + E++EK  ++
Sbjct: 343 MMW-EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ 382



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 38/133 (28%), Positives = 78/133 (58%), Gaps = 10/133 (7%)

Query: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK 588
           + +EK R++ E +R +EE  Q + +K+ E      EE   ++EE++++  +   R E+  
Sbjct: 623 EQEEKIREQEEKIREQEEMTQEQEEKMGEQ-----EEKMCEQEEKMQEQEETMWRQEEKI 677

Query: 589 EEKKKQIEQKFAQIDEKTE--KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE---ARR 643
            E++K+I ++  +I E+ E  + +EE++ E++ K     +KM+E E + +++EE    + 
Sbjct: 678 REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 737

Query: 644 LRWLQQEEEERRH 656
           +R  QQEE+ + H
Sbjct: 738 VRLRQQEEKMQEH 750



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 31/121 (25%), Positives = 68/121 (56%), Gaps = 10/121 (8%)

Query: 520 IKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQ 579
           I+    +  + +EK  ++ E +  +EE    + Q+ EE   R+ E+++    E+ +K+ +
Sbjct: 635 IREQEEMTQEQEEKMGEQEEKMCEQEE----KMQEQEETMWRQEEKIR----EQEKKIRE 686

Query: 580 ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 639
             E++ + +E  ++Q E+ + Q ++  E  +EE++ E++ K +   +KM E E R +Q+E
Sbjct: 687 QEEKIREQEEMMQEQEEKMWEQEEKMCE--QEEKMQEQEEKMRRQEEKMWEQEVRLRQQE 744

Query: 640 E 640
           E
Sbjct: 745 E 745



 Score = 35.4 bits (80), Expect = 0.24
 Identities = 36/189 (19%), Positives = 82/189 (43%), Gaps = 13/189 (6%)

Query: 429 QQEAKTDQADGPREPPQSARRK----RSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCP 484
           Q++    Q +  RE  +   R+    R  ++   E +E+   ++E+++    K       
Sbjct: 568 QEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEK 627

Query: 485 ASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRK 544
             +    +R      Q  +  M          +  ++         +EK R++ + +R +
Sbjct: 628 IREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQ 687

Query: 545 EEA--EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQI 602
           EE   EQ    + +E+K    EE   ++EE++      +E+ E+M+ +++K  EQ+  ++
Sbjct: 688 EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM------QEQEEKMRRQEEKMWEQE-VRL 740

Query: 603 DEKTEKAKE 611
            ++ EK +E
Sbjct: 741 RQQEEKMQE 749


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score =  127 bits (318), Expect = 6e-29
 Identities = 83/273 (30%), Positives = 170/273 (62%), Gaps = 29/273 (10%)

Query: 529 DPKEKERQRLENLRRKEEA-----EQLRRQKV----EEDKRRRLEEVKLKREERLRKVLQ 579
           + +EK R++ E +RR+EE      E++RRQ+     +E+K RR EE+  ++EE++R++ +
Sbjct: 386 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 445

Query: 580 ARERVEQMKE-EKKKQIEQKFAQIDEKTE------------KAKEERLAEEKAKKKAAAK 626
                E+++E E+K+Q E+K  + +++ E            + +EE++ E++ K     +
Sbjct: 446 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEE 505

Query: 627 KMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKE--EEQERLRKAAEAKRLAEQR 684
           K+ E E  R++E+   +    +QEE+ R  +E+ ++K++  E++E++RK  E K   ++ 
Sbjct: 506 KIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEE-KMWRQEE 564

Query: 685 EQERREQERREQERREQERREQERREQERQLAEQERR-REQERLQAERE--LQEREKALR 741
           +   +E++ REQE +   R+E++ REQE ++ EQE + REQE +  E+E  + E+E+ + 
Sbjct: 565 KMHDQEEKIREQEEKVW-RQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMC 623

Query: 742 LQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 774
            Q+E++Q + E+ +++EE+ R  E++++E++EK
Sbjct: 624 EQEEKMQEQEEKMRRQEEKIREQEKKIREQEEK 656



 Score =  124 bits (310), Expect = 5e-28
 Identities = 83/265 (31%), Positives = 163/265 (61%), Gaps = 27/265 (10%)

Query: 536 QRLENLRRKEE-----AEQLRRQK----VEEDKRRRLEEVKLKREERLRKVLQARERVEQ 586
           ++ E +RR+EE      E++RRQ+     +E+K R LEE K+  +E++R+  + R+  E+
Sbjct: 407 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE-KMHEQEKIREQEEKRQEEEK 465

Query: 587 MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 646
           ++E++K+Q ++      E+  + +EE++ E++ K     +K+ E E  R++E+   +   
Sbjct: 466 IREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEM 525

Query: 647 LQQEEEERRHQELLQKKKE--EEQERLRKAAEAKRLAEQR----EQERREQE----RREQ 696
            +QEE+ R  +E+ ++K++  E++E++RK  E     E++    E++ REQE    R+E+
Sbjct: 526 WRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEE 585

Query: 697 ERREQER--REQER--REQERQLAEQERR---REQERLQAERELQEREKALRLQKEQLQR 749
           + REQE   REQE   REQE    EQE +   +E++  + E ++QE+E+ +R Q+E+++ 
Sbjct: 586 KIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIRE 645

Query: 750 ELEEKKKKEEQQRLAERQLQEEQEK 774
           + ++ +++EE+ R  E  +QE++EK
Sbjct: 646 QEKKIREQEEKIREQEEMMQEQEEK 670



 Score =  123 bits (308), Expect = 9e-28
 Identities = 81/267 (30%), Positives = 163/267 (61%), Gaps = 23/267 (8%)

Query: 529 DPKEKERQRLENLRRKEEAEQLRRQKV----EEDKRRRLEEVKLKREERLRKVLQARERV 584
           + +EK R++ E +R +EE  ++RRQ+     +E+K RR EE+  ++EE++R+    +E +
Sbjct: 379 EQEEKIREQEEKIREQEE--KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR----QEEM 432

Query: 585 EQMKEEKKKQIEQKFAQ---IDEKTEKAKEE-RLAEEKAKKKAAAKKMEEVEARRKQEEE 640
              KEEK +++E+K  +   I E+ EK +EE ++ E++ +++  AK   + E  R+QEE+
Sbjct: 433 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 492

Query: 641 ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER-- 698
            R        +EE+ H++   +++E+ QE+     + +++ EQ E  R++++  EQE   
Sbjct: 493 IREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKI 552

Query: 699 REQE----RREQERREQERQLAEQER---RREQERLQAERELQEREKALRLQKEQLQREL 751
           R+QE    R+E++  +QE ++ EQE    R+E++  + E +++E+E+ +R Q+E  Q + 
Sbjct: 553 RKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQE 612

Query: 752 EEKKKKEEQQRLAERQLQEEQEKKAKE 778
           E+  ++EE+    E ++QE++EK  ++
Sbjct: 613 EKMGEQEEKMCEQEEKMQEQEEKMRRQ 639



 Score =  122 bits (305), Expect = 2e-27
 Identities = 83/284 (29%), Positives = 170/284 (59%), Gaps = 25/284 (8%)

Query: 520 IKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQ 579
           ++R   +  + +EK R++ E +  KEE  +   +K+ E ++ R +E K + EE++R+  +
Sbjct: 412 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 471

Query: 580 ARERVEQM--KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV----EA 633
            +E+  +M  +EEK ++ E+K  + +EK  + +E+   +EK +++   ++ EE+    E 
Sbjct: 472 RQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 531

Query: 634 RRKQEEEARRLRWLQQEEEERRHQE----LLQKKKEEEQERLRKAAE-----AKRLAEQR 684
            R+QEE  R+   + ++EE+ R QE      ++K  +++E++R+  E      +++ EQ 
Sbjct: 532 IREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQE 591

Query: 685 EQERREQER-REQERREQERR----EQERR--EQERQLAEQE---RRREQERLQAERELQ 734
           E+ R ++E+ REQE   QE+     EQE +  EQE ++ EQE   RR+E++  + E++++
Sbjct: 592 EKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIR 651

Query: 735 EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
           E+E+ +R Q+E +Q + E+  ++EE+    E ++QE++EK  ++
Sbjct: 652 EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 695



 Score =  120 bits (301), Expect = 6e-27
 Identities = 107/463 (23%), Positives = 229/463 (49%), Gaps = 38/463 (8%)

Query: 318 LAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKE 377
           L +K  LV  ++S ++   + L +K                LER   +   Q++ +E   
Sbjct: 287 LQEKLQLVESEKSEIQLNVKELKRK----------------LERAKLLLPQQQLQAEADH 330

Query: 378 PPEEAEPVAAA-EPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQ 436
             +E + V+A  + +V EN     W   + +        +      E     Q+E   +Q
Sbjct: 331 LGKELQSVSAKLQAQVEENE---LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ 387

Query: 437 ADGPREPPQSARRKRSYKQAVSELDEEQHLEDE---ELQPPRSKTPSSPCPASKVVRPLR 493
            +  RE  +  RR+   ++ + E +E+   ++E   E +    +         + +R L 
Sbjct: 388 EEKIREQEEKMRRQ---EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 444

Query: 494 TFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRM-DPKEKERQRLENLRRKEEAEQLRR 552
             +H  ++ +           + +   ++    +M   +EK R++ E +R +EE    + 
Sbjct: 445 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQE 504

Query: 553 QKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKK-KQIEQKFAQIDEKTEKAKE 611
           +K+ E ++ R EE + ++EE  R+  + RE+ E  ++++K  + E+K  + +EK  + +E
Sbjct: 505 EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEE 564

Query: 612 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL 671
           +   +E+  ++   K   + E  R+QEE+ R     +QEE+ R  +E+ Q+++E+  E+ 
Sbjct: 565 KMHDQEEKIREQEEKVWRQEEKIREQEEKIR-----EQEEKIREQEEMTQEQEEKMGEQE 619

Query: 672 RKAAEAKRLAEQREQERREQERREQER-REQERREQERREQERQLAEQERRREQERLQAE 730
            K  E     E++ QE+ E+ RR++E+ REQE++ +E+ E+ R+  E  + +E++  + E
Sbjct: 620 EKMCEQ----EEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE 675

Query: 731 RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQE 773
            ++ E+E+ ++ Q+E+++R+ E+  ++E + R  E ++QE QE
Sbjct: 676 EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718



 Score =  116 bits (291), Expect = 8e-26
 Identities = 80/261 (30%), Positives = 162/261 (62%), Gaps = 21/261 (8%)

Query: 531 KEKERQRLENLRRKEE-AEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKE 589
           +E++RQ  E +R +E+  EQ  +   +E+K R  EE   ++EE++ +  +     E+++E
Sbjct: 456 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIRE 515

Query: 590 EKKKQIEQKFAQIDEKTEKAKE-----ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 644
           E+K+Q +++  + +EK  + +E     E++ E++ K +   +KM   E +   +EE  R 
Sbjct: 516 EEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIR- 574

Query: 645 RWLQQEEEERRHQELLQKKKE---EEQERLRKAAEAKRLAEQR--EQERR--EQERREQE 697
              +QEE+  R +E +++++E   E++E++R+  E  +  E++  EQE +  EQE + QE
Sbjct: 575 ---EQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 631

Query: 698 RREQERREQER-REQERQLAEQERR-REQERLQAERE--LQEREKALRLQKEQLQRELEE 753
           + E+ RR++E+ REQE+++ EQE + REQE +  E+E  + E+E+ +  Q+E++Q + E+
Sbjct: 632 QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 691

Query: 754 KKKKEEQQRLAERQLQEEQEK 774
            +++EE+    E +L++++EK
Sbjct: 692 MRRQEEKMWEQEVRLRQQEEK 712



 Score =  114 bits (285), Expect = 4e-25
 Identities = 87/299 (29%), Positives = 166/299 (55%), Gaps = 39/299 (13%)

Query: 513 RSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKL---- 568
           R  +   + RNT    + KEK  +  E L+  E  +   +  V+E KR+ LE  KL    
Sbjct: 263 RDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRK-LERAKLLLPQ 321

Query: 569 -----------KREERLRKVLQAR-------ERVEQMKEEKKKQIEQKFAQIDEKTEKAK 610
                      K  + +   LQA+        R+ Q +EEK  + E+K  + +EK ++ +
Sbjct: 322 QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQE-Q 380

Query: 611 EERLAEEKAKKKAAAKKMEEVEARRKQEEEARR----LRWLQQEEEERRHQELLQKKKEE 666
           EE++ E++ K +   +KM   E    ++EE  R    + W ++EE+ RR +E++ +K+E+
Sbjct: 381 EEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW-EKEEKMRRQEEMMWEKEEK 439

Query: 667 EQERLRKAAEAKRLAEQREQERREQERREQERREQE-----RREQERREQERQLAEQERR 721
            +E   K  E +++ EQ E+ + E++ REQE+R+++     R+E++ REQE ++ EQE +
Sbjct: 440 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEK 499

Query: 722 --REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
             R++E++  + +++E EK  R ++E++ R+ E+ +++EE  R  E+ + E++EK  K+
Sbjct: 500 MWRQEEKIHEQEKIREEEK--RQEQEEMWRQEEKIREQEEIWRQKEK-IHEQEEKIRKQ 555



 Score =  111 bits (277), Expect = 4e-24
 Identities = 79/248 (31%), Positives = 147/248 (59%), Gaps = 26/248 (10%)

Query: 535 RQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ 594
           +Q+ E + R+EE  Q   +K++E + +  E+     EE++R+  +   R E+M  EK+++
Sbjct: 357 QQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ-----EEKIREQEEKMRRQEEMMWEKEEK 411

Query: 595 IEQKFAQIDEKTEKAK--EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 652
           + ++   + EK EK +  EE + E++ K +   +KM E E  R+QEE+       +QEEE
Sbjct: 412 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK-------RQEEE 464

Query: 653 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQE---RREQERREQE--RREQE 707
           + R QE     K +EQE  +   + +++ EQ E+ R ++E   R+E++  EQE  R E++
Sbjct: 465 KIREQE-----KRQEQE-AKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEK 518

Query: 708 RREQERQLAEQERRREQERLQAERE-LQEREKALRLQKEQLQRELEEKKKKEEQQRLAER 766
           R+EQE    ++E+ REQE +  ++E + E+E+ +R Q+E++ R+ E+   +EE+ R  E 
Sbjct: 519 RQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEE 578

Query: 767 QLQEEQEK 774
           ++  ++EK
Sbjct: 579 KVWRQEEK 586



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 66/251 (26%), Positives = 134/251 (53%), Gaps = 32/251 (12%)

Query: 531 KEKERQRLENLRRKEEAEQLR--RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK 588
           K+K  + +E L ++ +A  L   R  + +++   L+E   K +E+L+ V   +  ++   
Sbjct: 249 KKKADRYIEELTKERDALSLELYRNTITDEE---LKEKNAKLQEKLQLVESEKSEIQLNV 305

Query: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648
           +E K+++E+    + ++  +A+ + L +E     A      +++A+ ++ E   RL   Q
Sbjct: 306 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA------KLQAQVEENELWNRLNQ-Q 358

Query: 649 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 708
           QEE+  R +E +Q+ +E+ QE+                   E++ REQE + +E+ E+ R
Sbjct: 359 QEEKMWRQEEKIQEWEEKIQEQ-------------------EEKIREQEEKIREQEEKMR 399

Query: 709 REQERQLAEQERRREQERLQAER-ELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ 767
           R++E    ++E+ R QE +  E+ E   R++ +  +KE+  RELEEK  ++E+ R  E +
Sbjct: 400 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 459

Query: 768 LQEEQEKKAKE 778
            QEE++ + +E
Sbjct: 460 RQEEEKIREQE 470



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 48/158 (30%), Positives = 92/158 (58%), Gaps = 14/158 (8%)

Query: 529 DPKEKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERL----RKVLQARE 582
           D +EK R++ E + R+EE  + + +K+  +E+K R  EE+  ++EE++     K+ +  E
Sbjct: 568 DQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE 627

Query: 583 RVEQMKEEKKKQ---IEQKFAQIDEKTEKAKE--ERLAEEKAKKKAAAKKM-EEVEARRK 636
           ++++ +E+ ++Q   I ++  +I E+ EK +E  E + E++ K     +KM E+ E  ++
Sbjct: 628 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 687

Query: 637 QEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKA 674
           QEE+ RR      E+E R  Q+  ++K +E QE L  A
Sbjct: 688 QEEKMRRQEEKMWEQEVRLRQQ--EEKMQEHQEHLEAA 723



 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 67/277 (24%), Positives = 133/277 (48%), Gaps = 38/277 (13%)

Query: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVL-QARERVEQM 587
           D ++   Q  E LRR+ EA Q+   ++   ++  L+      +  ++++  +AR+ + ++
Sbjct: 170 DEQKASHQHQEALRRELEA-QVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 228

Query: 588 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK------KMEEVEARRKQEEEA 641
            +  K   E + A     T+K K +R  EE  K++ A         + + E + K  +  
Sbjct: 229 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 288

Query: 642 RRLRWLQQEEEE-------------RRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER 688
            +L+ ++ E+ E             R    L Q++ + E + L K  ++     Q + E 
Sbjct: 289 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 348

Query: 689 REQERREQERREQE--RREQERREQERQLAEQERR-REQERLQAERELQEREKALRLQKE 745
            E   R  +++E++  R+E++ +E E ++ EQE + REQE      +++E+E+ +R Q+E
Sbjct: 349 NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE-----KIREQEEKMRRQEE 403

Query: 746 QLQRELEEKKK--------KEEQQRLAERQLQEEQEK 774
            +  E EEK +        KEE+ R  E  + E++EK
Sbjct: 404 MMW-EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 439


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sapiens]
          Length = 1293

 Score =  120 bits (301), Expect = 6e-27
 Identities = 95/306 (31%), Positives = 164/306 (53%), Gaps = 36/306 (11%)

Query: 521  KRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEV-KLKREERLRKVLQ 579
            +R   +R   +E+ER+R E LRR++E E LRRQ+ EE KRR  EE+ + K+EE LR+  +
Sbjct: 735  RREAEMRAKREEEERKRQEELRRQQE-EILRRQQEEERKRREEEELARRKQEEALRRQRE 793

Query: 580  ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 639
                + + +EE+++Q      Q +E   + +E R  EE+ +K        + E  RKQEE
Sbjct: 794  QEIALRRQREEEERQ------QQEEALRRLEERRREEEERRK--------QEELLRKQEE 839

Query: 640  EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERR 699
            EA   +W ++EEE +R  E  + + EEE  RLR   E ++  E   Q ++E  R+ Q+++
Sbjct: 840  EA--AKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQ 897

Query: 700  EQERREQERREQERQLAE----------QERRREQERLQAERELQEREKALRLQKEQLQR 749
            E  RR Q+ ++Q++QLA+          Q+      + QA   L E +K L  ++E+  R
Sbjct: 898  EALRRLQQ-QQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQK-LEEERERQLR 955

Query: 750  ELEEKKKKEEQQRLAERQLQEEQEK-----KAKEAAGASKALNVTVDVQSPACTSYQMTP 804
            E E+++++ E  +  ++Q Q++Q+K        + +G +K+L      ++      Q   
Sbjct: 956  E-EQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQ 1014

Query: 805  QGHRAP 810
            Q H+ P
Sbjct: 1015 QQHQQP 1020



 Score =  115 bits (288), Expect = 2e-25
 Identities = 87/291 (29%), Positives = 157/291 (53%), Gaps = 32/291 (10%)

Query: 506 MTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEE 565
           + PT++  +V +     + PL         ++L+ L  K +A +L +++ E + R + EE
Sbjct: 688 LQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLE-KAKAAKLEQERREAEMRAKREE 746

Query: 566 VKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAA 625
            + KR+E LR+  Q  E + + +EE++K+ E+      E+  + K+E     + +++ A 
Sbjct: 747 EERKRQEELRR--QQEEILRRQQEEERKRREE------EELARRKQEEALRRQREQEIAL 798

Query: 626 KKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE----------------EQE 669
           ++  E E R++QEE  RRL   ++EEEERR QE L +K+EE                E+ 
Sbjct: 799 RRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEEN 858

Query: 670 RLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRRE--QERL 727
           RLR   EA RL  + E+ER+ +E   Q ++E  R+ Q+++E  R+L +Q+++++  Q +L
Sbjct: 859 RLRMEEEAARLRHE-EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKL 917

Query: 728 QAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
            +     ++      Q  Q    L E +K EE++   ERQL+EEQ ++ +E
Sbjct: 918 PSSSTWGQQSNTTACQ-SQATLSLAEIQKLEEER---ERQLREEQRRQQRE 964



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 48/133 (36%), Positives = 85/133 (63%), Gaps = 11/133 (8%)

Query: 660 LQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER--REQERREQERREQERQLAE 717
           L+K K  + E+ R+ AE +   E+ E++R+E+ RR+QE   R Q+  E++RRE+E    E
Sbjct: 723 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE----E 778

Query: 718 QERRREQERLQAERELQ-----EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 772
             RR+++E L+ +RE +     +RE+  R Q+E+  R LEE++++EE++R  E  L++++
Sbjct: 779 LARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE 838

Query: 773 EKKAKEAAGASKA 785
           E+ AK A    +A
Sbjct: 839 EEAAKWAREEEEA 851



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 112/531 (21%), Positives = 205/531 (38%), Gaps = 97/531 (18%)

Query: 287 PDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEE 346
           PD  +   G +TD   V  S   P + S        S    QE+   +  R+   KT + 
Sbjct: 342 PDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEA--SQFERKDEPKTEQT 399

Query: 347 PAASGRIICHSYLERLLNVEVPQKVGSEQ---------KEPPEEAEPVAAAEPEVPENNG 397
             A       + +E  L  +VP + G E          + P + A P+    P VP    
Sbjct: 400 EKAEEE----TRMENSLPAKVPSR-GDEMVADVQQPLSQIPSDTASPLLILPPPVP---- 450

Query: 398 NNSWPHNDTEIANSTPNPKPAASSPETP-----SAGQQEAKTDQADGPREPPQSARRKRS 452
                           NP P     ETP       G    + D  +G +   Q A +  +
Sbjct: 451 ----------------NPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVA 494

Query: 453 YKQAVSELDEEQHLEDEELQPPRSKTPSSPC------------PASKVVRPLRTFLHTVQ 500
           Y Q  S LD+E+     +LQ  R+K  S P             P  ++  P         
Sbjct: 495 YLQD-SALDDERLAS--KLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFN------- 544

Query: 501 RNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKR 560
            NQ +     A    M   +KR         ++  Q L ++ +                 
Sbjct: 545 -NQEMAEWFQAGYFTMSLLVKRAC-------DESFQPLGDIMKMWGRVPFSPGPAPPPHM 596

Query: 561 RRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAK 620
             L++ +L R++ L  + Q      Q  + ++  I+Q++AQ+      A++++ A    +
Sbjct: 597 GELDQERLTRQQELTALYQM-----QHLQYQQFLIQQQYAQV-----LAQQQKAALSSQQ 646

Query: 621 KKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER---------- 670
           ++  A  +++ +  + +  +   +  + +         + + +    Q            
Sbjct: 647 QQQLALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDL 706

Query: 671 -LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQA 729
            L        L + ++ E+ +  + EQERRE E R + R E+ER+  E+ RR+++E L  
Sbjct: 707 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAK-REEEERKRQEELRRQQEEIL-- 763

Query: 730 ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA-ERQLQEEQEKKAKEA 779
            R  QE E+  R ++E  +R+ EE  +++ +Q +A  RQ +EE+ ++ +EA
Sbjct: 764 -RRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEA 813



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 78/375 (20%), Positives = 163/375 (43%), Gaps = 70/375 (18%)

Query: 381  EAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPK-PAASSPETPSAGQQEAKTDQAD- 438
            E +P A+ +P V E  G + W   D  +  +TP P        E   A + E +  +A+ 
Sbjct: 687  ELQPTAS-QPTVWE--GGSVW---DLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEM 740

Query: 439  -GPREPPQSARR---KRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRT 494
               RE  +  R+   +R  ++ +    EE+    EE +  R K   +     +    LR 
Sbjct: 741  RAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRR 800

Query: 495  FLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQK 554
                 +R Q             +  ++R    R +  E+ER++ E L RK+E E  +  +
Sbjct: 801  QREEEERQQQ------------EEALRRLEERRRE--EEERRKQEELLRKQEEEAAKWAR 846

Query: 555  VEEDKRRRLEEVKLK-----------REERLRKVLQARERVEQMKEEKKKQIEQKFAQID 603
             EE+ +RRLEE +L+            EER RK L+ + + E M++ +++Q   +  Q  
Sbjct: 847  EEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQ 906

Query: 604  EKTEKAKEERL-----------------------AEEKAKKKAAAKKMEEVEARRKQEEE 640
            ++ ++  + +L                       AE +  ++   +++ E + R+++E  
Sbjct: 907  QQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRE-- 964

Query: 641  ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 700
               ++ LQQ+++++      Q+K        + +   K L E +++E R+ ++++Q++++
Sbjct: 965  --LMKALQQQQQQQ------QQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQ 1016

Query: 701  QERREQERREQERQL 715
             ++  + R      L
Sbjct: 1017 HQQPNRARNNTHSNL 1031



 Score = 34.3 bits (77), Expect = 0.54
 Identities = 21/93 (22%), Positives = 50/93 (53%), Gaps = 1/93 (1%)

Query: 671  LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE 730
            L   +EAK  A+Q   ERR +++  Q+R++Q+  +Q++++  +Q  +Q ++++       
Sbjct: 1172 LGDTSEAKEFAKQF-LERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNH 1230

Query: 731  RELQEREKALRLQKEQLQRELEEKKKKEEQQRL 763
              L    +  +   +Q   E  +  KK+++Q++
Sbjct: 1231 STLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKM 1263



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 35/168 (20%), Positives = 73/168 (43%), Gaps = 14/168 (8%)

Query: 17  QKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQD 76
           +K  E L   + +   W  E +EEA+R       +  E   +   ++  RK++ +  VQ 
Sbjct: 828 RKQEELLRKQEEEAAKWARE-EEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE-VQ- 884

Query: 77  ENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATM 136
                 R++   R+ +  Q + RRL+ +   ++LA +   + S   + +   A  + AT+
Sbjct: 885 ------RQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATL 938

Query: 137 ALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVT 184
           +LA       E    L  + E    Q +L+  ++    ++Q  +Q ++
Sbjct: 939 SLAEIQKLEEERERQL--REEQRRQQRELMKALQ---QQQQQQQQKLS 981


>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
          Length = 1320

 Score =  120 bits (301), Expect = 6e-27
 Identities = 95/306 (31%), Positives = 164/306 (53%), Gaps = 36/306 (11%)

Query: 521  KRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEV-KLKREERLRKVLQ 579
            +R   +R   +E+ER+R E LRR++E E LRRQ+ EE KRR  EE+ + K+EE LR+  +
Sbjct: 762  RREAEMRAKREEEERKRQEELRRQQE-EILRRQQEEERKRREEEELARRKQEEALRRQRE 820

Query: 580  ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 639
                + + +EE+++Q      Q +E   + +E R  EE+ +K        + E  RKQEE
Sbjct: 821  QEIALRRQREEEERQ------QQEEALRRLEERRREEEERRK--------QEELLRKQEE 866

Query: 640  EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERR 699
            EA   +W ++EEE +R  E  + + EEE  RLR   E ++  E   Q ++E  R+ Q+++
Sbjct: 867  EA--AKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQ 924

Query: 700  EQERREQERREQERQLAE----------QERRREQERLQAERELQEREKALRLQKEQLQR 749
            E  RR Q+ ++Q++QLA+          Q+      + QA   L E +K L  ++E+  R
Sbjct: 925  EALRRLQQ-QQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQK-LEEERERQLR 982

Query: 750  ELEEKKKKEEQQRLAERQLQEEQEK-----KAKEAAGASKALNVTVDVQSPACTSYQMTP 804
            E E+++++ E  +  ++Q Q++Q+K        + +G +K+L      ++      Q   
Sbjct: 983  E-EQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQ 1041

Query: 805  QGHRAP 810
            Q H+ P
Sbjct: 1042 QQHQQP 1047



 Score =  115 bits (288), Expect = 2e-25
 Identities = 87/291 (29%), Positives = 157/291 (53%), Gaps = 32/291 (10%)

Query: 506 MTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEE 565
           + PT++  +V +     + PL         ++L+ L  K +A +L +++ E + R + EE
Sbjct: 715 LQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLE-KAKAAKLEQERREAEMRAKREE 773

Query: 566 VKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAA 625
            + KR+E LR+  Q  E + + +EE++K+ E+      E+  + K+E     + +++ A 
Sbjct: 774 EERKRQEELRR--QQEEILRRQQEEERKRREE------EELARRKQEEALRRQREQEIAL 825

Query: 626 KKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE----------------EQE 669
           ++  E E R++QEE  RRL   ++EEEERR QE L +K+EE                E+ 
Sbjct: 826 RRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEEN 885

Query: 670 RLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRRE--QERL 727
           RLR   EA RL  + E+ER+ +E   Q ++E  R+ Q+++E  R+L +Q+++++  Q +L
Sbjct: 886 RLRMEEEAARLRHE-EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKL 944

Query: 728 QAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
            +     ++      Q  Q    L E +K EE++   ERQL+EEQ ++ +E
Sbjct: 945 PSSSTWGQQSNTTACQ-SQATLSLAEIQKLEEER---ERQLREEQRRQQRE 991



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 48/133 (36%), Positives = 85/133 (63%), Gaps = 11/133 (8%)

Query: 660 LQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER--REQERREQERREQERQLAE 717
           L+K K  + E+ R+ AE +   E+ E++R+E+ RR+QE   R Q+  E++RRE+E    E
Sbjct: 750 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE----E 805

Query: 718 QERRREQERLQAERELQ-----EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 772
             RR+++E L+ +RE +     +RE+  R Q+E+  R LEE++++EE++R  E  L++++
Sbjct: 806 LARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE 865

Query: 773 EKKAKEAAGASKA 785
           E+ AK A    +A
Sbjct: 866 EEAAKWAREEEEA 878



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 85/396 (21%), Positives = 164/396 (41%), Gaps = 61/396 (15%)

Query: 413 PNPKPAASSPETP-----SAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLE 467
           PNP P     ETP       G    + D  +G +   Q A +  +Y Q  S LD+E+   
Sbjct: 477 PNPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVAYLQD-SALDDERLAS 535

Query: 468 DEELQPPRSKTPSSPC------------PASKVVRPLRTFLHTVQRNQMLMTPTSAPRSV 515
             +LQ  R+K  S P             P  ++  P          NQ +     A    
Sbjct: 536 --KLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFN--------NQEMAEWFQAGYFT 585

Query: 516 MKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR 575
           M   +KR         ++  Q L ++ +                   L++ +L R++ L 
Sbjct: 586 MSLLVKRAC-------DESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELT 638

Query: 576 KVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARR 635
            + Q      Q  + ++  I+Q++AQ+      A++++ A    +++  A  +++ +  +
Sbjct: 639 ALYQM-----QHLQYQQFLIQQQYAQV-----LAQQQKAALSSQQQQQLALLLQQFQTLK 688

Query: 636 KQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER-----------LRKAAEAKRLAEQR 684
            +  +   +  + +         + + +    Q             L        L + +
Sbjct: 689 MRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQ 748

Query: 685 EQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQK 744
           + E+ +  + EQERRE E R + R E+ER+  E+ RR+++E L   R  QE E+  R ++
Sbjct: 749 QLEKAKAAKLEQERREAEMRAK-REEEERKRQEELRRQQEEIL---RRQQEEERKRREEE 804

Query: 745 EQLQRELEEKKKKEEQQRLA-ERQLQEEQEKKAKEA 779
           E  +R+ EE  +++ +Q +A  RQ +EE+ ++ +EA
Sbjct: 805 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEA 840



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 78/375 (20%), Positives = 163/375 (43%), Gaps = 70/375 (18%)

Query: 381  EAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPK-PAASSPETPSAGQQEAKTDQAD- 438
            E +P A+ +P V E  G + W   D  +  +TP P        E   A + E +  +A+ 
Sbjct: 714  ELQPTAS-QPTVWE--GGSVW---DLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEM 767

Query: 439  -GPREPPQSARR---KRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRT 494
               RE  +  R+   +R  ++ +    EE+    EE +  R K   +     +    LR 
Sbjct: 768  RAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRR 827

Query: 495  FLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQK 554
                 +R Q             +  ++R    R +  E+ER++ E L RK+E E  +  +
Sbjct: 828  QREEEERQQQ------------EEALRRLEERRRE--EEERRKQEELLRKQEEEAAKWAR 873

Query: 555  VEEDKRRRLEEVKLK-----------REERLRKVLQARERVEQMKEEKKKQIEQKFAQID 603
             EE+ +RRLEE +L+            EER RK L+ + + E M++ +++Q   +  Q  
Sbjct: 874  EEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQ 933

Query: 604  EKTEKAKEERL-----------------------AEEKAKKKAAAKKMEEVEARRKQEEE 640
            ++ ++  + +L                       AE +  ++   +++ E + R+++E  
Sbjct: 934  QQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRE-- 991

Query: 641  ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 700
               ++ LQQ+++++      Q+K        + +   K L E +++E R+ ++++Q++++
Sbjct: 992  --LMKALQQQQQQQ------QQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQ 1043

Query: 701  QERREQERREQERQL 715
             ++  + R      L
Sbjct: 1044 HQQPNRARNNTHSNL 1058



 Score = 34.3 bits (77), Expect = 0.54
 Identities = 21/93 (22%), Positives = 50/93 (53%), Gaps = 1/93 (1%)

Query: 671  LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE 730
            L   +EAK  A+Q   ERR +++  Q+R++Q+  +Q++++  +Q  +Q ++++       
Sbjct: 1199 LGDTSEAKEFAKQF-LERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNH 1257

Query: 731  RELQEREKALRLQKEQLQRELEEKKKKEEQQRL 763
              L    +  +   +Q   E  +  KK+++Q++
Sbjct: 1258 STLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKM 1290



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 35/168 (20%), Positives = 73/168 (43%), Gaps = 14/168 (8%)

Query: 17   QKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQD 76
            +K  E L   + +   W  E +EEA+R       +  E   +   ++  RK++ +  VQ 
Sbjct: 855  RKQEELLRKQEEEAAKWARE-EEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE-VQ- 911

Query: 77   ENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATM 136
                  R++   R+ +  Q + RRL+ +   ++LA +   + S   + +   A  + AT+
Sbjct: 912  ------RQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATL 965

Query: 137  ALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVT 184
            +LA       E    L  + E    Q +L+  ++    ++Q  +Q ++
Sbjct: 966  SLAEIQKLEEERERQL--REEQRRQQRELMKALQ---QQQQQQQQKLS 1008


>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
          Length = 1299

 Score =  120 bits (301), Expect = 6e-27
 Identities = 95/306 (31%), Positives = 164/306 (53%), Gaps = 36/306 (11%)

Query: 521  KRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEV-KLKREERLRKVLQ 579
            +R   +R   +E+ER+R E LRR++E E LRRQ+ EE KRR  EE+ + K+EE LR+  +
Sbjct: 741  RREAEMRAKREEEERKRQEELRRQQE-EILRRQQEEERKRREEEELARRKQEEALRRQRE 799

Query: 580  ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 639
                + + +EE+++Q      Q +E   + +E R  EE+ +K        + E  RKQEE
Sbjct: 800  QEIALRRQREEEERQ------QQEEALRRLEERRREEEERRK--------QEELLRKQEE 845

Query: 640  EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERR 699
            EA   +W ++EEE +R  E  + + EEE  RLR   E ++  E   Q ++E  R+ Q+++
Sbjct: 846  EA--AKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQ 903

Query: 700  EQERREQERREQERQLAE----------QERRREQERLQAERELQEREKALRLQKEQLQR 749
            E  RR Q+ ++Q++QLA+          Q+      + QA   L E +K L  ++E+  R
Sbjct: 904  EALRRLQQ-QQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQK-LEEERERQLR 961

Query: 750  ELEEKKKKEEQQRLAERQLQEEQEK-----KAKEAAGASKALNVTVDVQSPACTSYQMTP 804
            E E+++++ E  +  ++Q Q++Q+K        + +G +K+L      ++      Q   
Sbjct: 962  E-EQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQ 1020

Query: 805  QGHRAP 810
            Q H+ P
Sbjct: 1021 QQHQQP 1026



 Score =  115 bits (288), Expect = 2e-25
 Identities = 87/291 (29%), Positives = 157/291 (53%), Gaps = 32/291 (10%)

Query: 506 MTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEE 565
           + PT++  +V +     + PL         ++L+ L  K +A +L +++ E + R + EE
Sbjct: 694 LQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLE-KAKAAKLEQERREAEMRAKREE 752

Query: 566 VKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAA 625
            + KR+E LR+  Q  E + + +EE++K+ E+      E+  + K+E     + +++ A 
Sbjct: 753 EERKRQEELRR--QQEEILRRQQEEERKRREE------EELARRKQEEALRRQREQEIAL 804

Query: 626 KKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE----------------EQE 669
           ++  E E R++QEE  RRL   ++EEEERR QE L +K+EE                E+ 
Sbjct: 805 RRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEEN 864

Query: 670 RLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRRE--QERL 727
           RLR   EA RL  + E+ER+ +E   Q ++E  R+ Q+++E  R+L +Q+++++  Q +L
Sbjct: 865 RLRMEEEAARLRHE-EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKL 923

Query: 728 QAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
            +     ++      Q  Q    L E +K EE++   ERQL+EEQ ++ +E
Sbjct: 924 PSSSTWGQQSNTTACQ-SQATLSLAEIQKLEEER---ERQLREEQRRQQRE 970



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 48/133 (36%), Positives = 85/133 (63%), Gaps = 11/133 (8%)

Query: 660 LQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER--REQERREQERREQERQLAE 717
           L+K K  + E+ R+ AE +   E+ E++R+E+ RR+QE   R Q+  E++RRE+E    E
Sbjct: 729 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE----E 784

Query: 718 QERRREQERLQAERELQ-----EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 772
             RR+++E L+ +RE +     +RE+  R Q+E+  R LEE++++EE++R  E  L++++
Sbjct: 785 LARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE 844

Query: 773 EKKAKEAAGASKA 785
           E+ AK A    +A
Sbjct: 845 EEAAKWAREEEEA 857



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 112/531 (21%), Positives = 205/531 (38%), Gaps = 97/531 (18%)

Query: 287 PDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEE 346
           PD  +   G +TD   V  S   P + S        S    QE+   +  R+   KT + 
Sbjct: 348 PDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEA--SQFERKDEPKTEQT 405

Query: 347 PAASGRIICHSYLERLLNVEVPQKVGSEQ---------KEPPEEAEPVAAAEPEVPENNG 397
             A       + +E  L  +VP + G E          + P + A P+    P VP    
Sbjct: 406 EKAEEE----TRMENSLPAKVPSR-GDEMVADVQQPLSQIPSDTASPLLILPPPVP---- 456

Query: 398 NNSWPHNDTEIANSTPNPKPAASSPETP-----SAGQQEAKTDQADGPREPPQSARRKRS 452
                           NP P     ETP       G    + D  +G +   Q A +  +
Sbjct: 457 ----------------NPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVA 500

Query: 453 YKQAVSELDEEQHLEDEELQPPRSKTPSSPC------------PASKVVRPLRTFLHTVQ 500
           Y Q  S LD+E+     +LQ  R+K  S P             P  ++  P         
Sbjct: 501 YLQD-SALDDERLAS--KLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFN------- 550

Query: 501 RNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKR 560
            NQ +     A    M   +KR         ++  Q L ++ +                 
Sbjct: 551 -NQEMAEWFQAGYFTMSLLVKRAC-------DESFQPLGDIMKMWGRVPFSPGPAPPPHM 602

Query: 561 RRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAK 620
             L++ +L R++ L  + Q      Q  + ++  I+Q++AQ+      A++++ A    +
Sbjct: 603 GELDQERLTRQQELTALYQM-----QHLQYQQFLIQQQYAQV-----LAQQQKAALSSQQ 652

Query: 621 KKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER---------- 670
           ++  A  +++ +  + +  +   +  + +         + + +    Q            
Sbjct: 653 QQQLALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDL 712

Query: 671 -LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQA 729
            L        L + ++ E+ +  + EQERRE E R + R E+ER+  E+ RR+++E L  
Sbjct: 713 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAK-REEEERKRQEELRRQQEEIL-- 769

Query: 730 ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA-ERQLQEEQEKKAKEA 779
            R  QE E+  R ++E  +R+ EE  +++ +Q +A  RQ +EE+ ++ +EA
Sbjct: 770 -RRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEA 819



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 78/375 (20%), Positives = 163/375 (43%), Gaps = 70/375 (18%)

Query: 381  EAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPK-PAASSPETPSAGQQEAKTDQAD- 438
            E +P A+ +P V E  G + W   D  +  +TP P        E   A + E +  +A+ 
Sbjct: 693  ELQPTAS-QPTVWE--GGSVW---DLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEM 746

Query: 439  -GPREPPQSARR---KRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRT 494
               RE  +  R+   +R  ++ +    EE+    EE +  R K   +     +    LR 
Sbjct: 747  RAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRR 806

Query: 495  FLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQK 554
                 +R Q             +  ++R    R +  E+ER++ E L RK+E E  +  +
Sbjct: 807  QREEEERQQQ------------EEALRRLEERRRE--EEERRKQEELLRKQEEEAAKWAR 852

Query: 555  VEEDKRRRLEEVKLK-----------REERLRKVLQARERVEQMKEEKKKQIEQKFAQID 603
             EE+ +RRLEE +L+            EER RK L+ + + E M++ +++Q   +  Q  
Sbjct: 853  EEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQ 912

Query: 604  EKTEKAKEERL-----------------------AEEKAKKKAAAKKMEEVEARRKQEEE 640
            ++ ++  + +L                       AE +  ++   +++ E + R+++E  
Sbjct: 913  QQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRE-- 970

Query: 641  ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 700
               ++ LQQ+++++      Q+K        + +   K L E +++E R+ ++++Q++++
Sbjct: 971  --LMKALQQQQQQQ------QQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQ 1022

Query: 701  QERREQERREQERQL 715
             ++  + R      L
Sbjct: 1023 HQQPNRARNNTHSNL 1037



 Score = 34.3 bits (77), Expect = 0.54
 Identities = 21/93 (22%), Positives = 50/93 (53%), Gaps = 1/93 (1%)

Query: 671  LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE 730
            L   +EAK  A+Q   ERR +++  Q+R++Q+  +Q++++  +Q  +Q ++++       
Sbjct: 1178 LGDTSEAKEFAKQF-LERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNH 1236

Query: 731  RELQEREKALRLQKEQLQRELEEKKKKEEQQRL 763
              L    +  +   +Q   E  +  KK+++Q++
Sbjct: 1237 STLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKM 1269



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 35/168 (20%), Positives = 73/168 (43%), Gaps = 14/168 (8%)

Query: 17  QKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQD 76
           +K  E L   + +   W  E +EEA+R       +  E   +   ++  RK++ +  VQ 
Sbjct: 834 RKQEELLRKQEEEAAKWARE-EEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE-VQ- 890

Query: 77  ENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATM 136
                 R++   R+ +  Q + RRL+ +   ++LA +   + S   + +   A  + AT+
Sbjct: 891 ------RQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATL 944

Query: 137 ALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVT 184
           +LA       E    L  + E    Q +L+  ++    ++Q  +Q ++
Sbjct: 945 SLAEIQKLEEERERQL--REEQRRQQRELMKALQ---QQQQQQQQKLS 987


>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
          Length = 1299

 Score =  120 bits (301), Expect = 6e-27
 Identities = 95/306 (31%), Positives = 164/306 (53%), Gaps = 36/306 (11%)

Query: 521  KRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEV-KLKREERLRKVLQ 579
            +R   +R   +E+ER+R E LRR++E E LRRQ+ EE KRR  EE+ + K+EE LR+  +
Sbjct: 741  RREAEMRAKREEEERKRQEELRRQQE-EILRRQQEEERKRREEEELARRKQEEALRRQRE 799

Query: 580  ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 639
                + + +EE+++Q      Q +E   + +E R  EE+ +K        + E  RKQEE
Sbjct: 800  QEIALRRQREEEERQ------QQEEALRRLEERRREEEERRK--------QEELLRKQEE 845

Query: 640  EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERR 699
            EA   +W ++EEE +R  E  + + EEE  RLR   E ++  E   Q ++E  R+ Q+++
Sbjct: 846  EA--AKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQ 903

Query: 700  EQERREQERREQERQLAE----------QERRREQERLQAERELQEREKALRLQKEQLQR 749
            E  RR Q+ ++Q++QLA+          Q+      + QA   L E +K L  ++E+  R
Sbjct: 904  EALRRLQQ-QQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQK-LEEERERQLR 961

Query: 750  ELEEKKKKEEQQRLAERQLQEEQEK-----KAKEAAGASKALNVTVDVQSPACTSYQMTP 804
            E E+++++ E  +  ++Q Q++Q+K        + +G +K+L      ++      Q   
Sbjct: 962  E-EQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQ 1020

Query: 805  QGHRAP 810
            Q H+ P
Sbjct: 1021 QQHQQP 1026



 Score =  115 bits (288), Expect = 2e-25
 Identities = 87/291 (29%), Positives = 157/291 (53%), Gaps = 32/291 (10%)

Query: 506 MTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEE 565
           + PT++  +V +     + PL         ++L+ L  K +A +L +++ E + R + EE
Sbjct: 694 LQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLE-KAKAAKLEQERREAEMRAKREE 752

Query: 566 VKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAA 625
            + KR+E LR+  Q  E + + +EE++K+ E+      E+  + K+E     + +++ A 
Sbjct: 753 EERKRQEELRR--QQEEILRRQQEEERKRREE------EELARRKQEEALRRQREQEIAL 804

Query: 626 KKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE----------------EQE 669
           ++  E E R++QEE  RRL   ++EEEERR QE L +K+EE                E+ 
Sbjct: 805 RRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEEN 864

Query: 670 RLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRRE--QERL 727
           RLR   EA RL  + E+ER+ +E   Q ++E  R+ Q+++E  R+L +Q+++++  Q +L
Sbjct: 865 RLRMEEEAARLRHE-EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKL 923

Query: 728 QAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
            +     ++      Q  Q    L E +K EE++   ERQL+EEQ ++ +E
Sbjct: 924 PSSSTWGQQSNTTACQ-SQATLSLAEIQKLEEER---ERQLREEQRRQQRE 970



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 48/133 (36%), Positives = 85/133 (63%), Gaps = 11/133 (8%)

Query: 660 LQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER--REQERREQERREQERQLAE 717
           L+K K  + E+ R+ AE +   E+ E++R+E+ RR+QE   R Q+  E++RRE+E    E
Sbjct: 729 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE----E 784

Query: 718 QERRREQERLQAERELQ-----EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 772
             RR+++E L+ +RE +     +RE+  R Q+E+  R LEE++++EE++R  E  L++++
Sbjct: 785 LARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE 844

Query: 773 EKKAKEAAGASKA 785
           E+ AK A    +A
Sbjct: 845 EEAAKWAREEEEA 857



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 112/531 (21%), Positives = 205/531 (38%), Gaps = 97/531 (18%)

Query: 287 PDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEE 346
           PD  +   G +TD   V  S   P + S        S    QE+   +  R+   KT + 
Sbjct: 348 PDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEA--SQFERKDEPKTEQT 405

Query: 347 PAASGRIICHSYLERLLNVEVPQKVGSEQ---------KEPPEEAEPVAAAEPEVPENNG 397
             A       + +E  L  +VP + G E          + P + A P+    P VP    
Sbjct: 406 EKAEEE----TRMENSLPAKVPSR-GDEMVADVQQPLSQIPSDTASPLLILPPPVP---- 456

Query: 398 NNSWPHNDTEIANSTPNPKPAASSPETP-----SAGQQEAKTDQADGPREPPQSARRKRS 452
                           NP P     ETP       G    + D  +G +   Q A +  +
Sbjct: 457 ----------------NPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVA 500

Query: 453 YKQAVSELDEEQHLEDEELQPPRSKTPSSPC------------PASKVVRPLRTFLHTVQ 500
           Y Q  S LD+E+     +LQ  R+K  S P             P  ++  P         
Sbjct: 501 YLQD-SALDDERLAS--KLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFN------- 550

Query: 501 RNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKR 560
            NQ +     A    M   +KR         ++  Q L ++ +                 
Sbjct: 551 -NQEMAEWFQAGYFTMSLLVKRAC-------DESFQPLGDIMKMWGRVPFSPGPAPPPHM 602

Query: 561 RRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAK 620
             L++ +L R++ L  + Q      Q  + ++  I+Q++AQ+      A++++ A    +
Sbjct: 603 GELDQERLTRQQELTALYQM-----QHLQYQQFLIQQQYAQV-----LAQQQKAALSSQQ 652

Query: 621 KKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER---------- 670
           ++  A  +++ +  + +  +   +  + +         + + +    Q            
Sbjct: 653 QQQLALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDL 712

Query: 671 -LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQA 729
            L        L + ++ E+ +  + EQERRE E R + R E+ER+  E+ RR+++E L  
Sbjct: 713 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAK-REEEERKRQEELRRQQEEIL-- 769

Query: 730 ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA-ERQLQEEQEKKAKEA 779
            R  QE E+  R ++E  +R+ EE  +++ +Q +A  RQ +EE+ ++ +EA
Sbjct: 770 -RRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEA 819



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 78/375 (20%), Positives = 163/375 (43%), Gaps = 70/375 (18%)

Query: 381  EAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPK-PAASSPETPSAGQQEAKTDQAD- 438
            E +P A+ +P V E  G + W   D  +  +TP P        E   A + E +  +A+ 
Sbjct: 693  ELQPTAS-QPTVWE--GGSVW---DLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEM 746

Query: 439  -GPREPPQSARR---KRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRT 494
               RE  +  R+   +R  ++ +    EE+    EE +  R K   +     +    LR 
Sbjct: 747  RAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRR 806

Query: 495  FLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQK 554
                 +R Q             +  ++R    R +  E+ER++ E L RK+E E  +  +
Sbjct: 807  QREEEERQQQ------------EEALRRLEERRRE--EEERRKQEELLRKQEEEAAKWAR 852

Query: 555  VEEDKRRRLEEVKLK-----------REERLRKVLQARERVEQMKEEKKKQIEQKFAQID 603
             EE+ +RRLEE +L+            EER RK L+ + + E M++ +++Q   +  Q  
Sbjct: 853  EEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQ 912

Query: 604  EKTEKAKEERL-----------------------AEEKAKKKAAAKKMEEVEARRKQEEE 640
            ++ ++  + +L                       AE +  ++   +++ E + R+++E  
Sbjct: 913  QQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRE-- 970

Query: 641  ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 700
               ++ LQQ+++++      Q+K        + +   K L E +++E R+ ++++Q++++
Sbjct: 971  --LMKALQQQQQQQ------QQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQ 1022

Query: 701  QERREQERREQERQL 715
             ++  + R      L
Sbjct: 1023 HQQPNRARNNTHSNL 1037



 Score = 34.3 bits (77), Expect = 0.54
 Identities = 21/93 (22%), Positives = 50/93 (53%), Gaps = 1/93 (1%)

Query: 671  LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE 730
            L   +EAK  A+Q   ERR +++  Q+R++Q+  +Q++++  +Q  +Q ++++       
Sbjct: 1178 LGDTSEAKEFAKQF-LERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNH 1236

Query: 731  RELQEREKALRLQKEQLQRELEEKKKKEEQQRL 763
              L    +  +   +Q   E  +  KK+++Q++
Sbjct: 1237 STLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKM 1269



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 35/168 (20%), Positives = 73/168 (43%), Gaps = 14/168 (8%)

Query: 17  QKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQD 76
           +K  E L   + +   W  E +EEA+R       +  E   +   ++  RK++ +  VQ 
Sbjct: 834 RKQEELLRKQEEEAAKWARE-EEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE-VQ- 890

Query: 77  ENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATM 136
                 R++   R+ +  Q + RRL+ +   ++LA +   + S   + +   A  + AT+
Sbjct: 891 ------RQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATL 944

Query: 137 ALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVT 184
           +LA       E    L  + E    Q +L+  ++    ++Q  +Q ++
Sbjct: 945 SLAEIQKLEEERERQL--REEQRRQQRELMKALQ---QQQQQQQQKLS 987


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score =  118 bits (296), Expect = 2e-26
 Identities = 83/251 (33%), Positives = 158/251 (62%), Gaps = 22/251 (8%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREER-LRKVLQARERVEQMKE 589
           +++ER R +  + +E+ E++RRQ    +KR R +E +L+ +E+ LR+  + RE+ EQM+E
Sbjct: 259 RQEERLREQEGKMREQEEKMRRQ----EKRLREQEKELREQEKELREQKKLREQEEQMQE 314

Query: 590 EKKKQIEQKFAQIDEKTEK--AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 647
           +++K  EQ+  ++ E+ EK   +EERL E++ + +   +KM + E R  +++E      L
Sbjct: 315 QEEKMWEQE-EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER-----L 368

Query: 648 QQEEEERRHQELL--QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE 705
           +++EE  R QE +  Q++K +E+ER+R   E ++   + E+  REQE + Q++ E    +
Sbjct: 369 REKEERMREQEKMWEQEEKMQEEERIR---EREKKMREEEETMREQEEKMQKQEENMWEQ 425

Query: 706 QERREQERQLAEQ-ERRREQERLQAERE-LQEREKALRLQKEQLQRELEEKKKKEEQQRL 763
           +E+  Q+++L EQ E+  EQE++Q + E + E+E+ +R Q+E   +  E+K  ++E+ R 
Sbjct: 426 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ--EKKMWRQEKMRE 483

Query: 764 AERQLQEEQEK 774
            E Q+ E++EK
Sbjct: 484 QEDQMWEQEEK 494



 Score =  117 bits (293), Expect = 5e-26
 Identities = 84/280 (30%), Positives = 163/280 (58%), Gaps = 35/280 (12%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERL-RKVLQARERVEQM 587
           +EKE +  + LR +EE  Q + +K+  +E+K R  EE   ++EERL  +  Q RE+ ++M
Sbjct: 295 QEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKM 354

Query: 588 KEEKKKQIEQKFAQIDEKTEKAKE--------ERLAEEKAKKKAAAKKMEEVEARRKQEE 639
           ++++++  EQ   ++ EK E+ +E        E++ EE+  ++   K  EE E  R+QEE
Sbjct: 355 RDQEERMWEQD-ERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEE 413

Query: 640 EARRLR---WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER--- 693
           + ++     W Q+E+E ++ +   QK+K  EQE++++  E  ++ EQ E+ R ++E    
Sbjct: 414 KMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE--KIWEQEEKIRDQEEMWGQ 471

Query: 694 -----REQERREQE----RREQERREQERQLAEQERR--REQERLQAERELQEREKALRL 742
                R+++ REQE     +E++ R+QE+++ +QE R   + ERL+ + E    +K +  
Sbjct: 472 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQ 531

Query: 743 QKEQLQREL----EEKKKKEEQQRLAERQLQEEQEKKAKE 778
           Q+E+++ E     +EKK  ++++++ E +   E+EKK +E
Sbjct: 532 QEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMRE 571



 Score =  117 bits (292), Expect = 6e-26
 Identities = 74/249 (29%), Positives = 147/249 (59%), Gaps = 14/249 (5%)

Query: 531 KEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK 588
           +EK+  R E +R +E+   EQ  + + +E K    EE   +++ERLR+  +     ++M 
Sbjct: 471 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMW 530

Query: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648
           ++++K  E+K  Q  EK    +EE++ EE+  ++   K  EE E  R+QEE+      +Q
Sbjct: 531 QQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK------MQ 584

Query: 649 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 708
           ++EE+ R QE   +K  E++E++++  E     E++  E+ E+++ +++      +E++ 
Sbjct: 585 EQEEKMREQE---EKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKM 641

Query: 709 REQERQLAEQERR-REQERLQAERE--LQEREKALRLQKEQLQRELEEKKKKEEQQRLAE 765
           +EQE ++ EQE + REQE    E+E  +Q +E+ +R Q+E++Q + E+ +++EE+ R  E
Sbjct: 642 QEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQE 701

Query: 766 RQLQEEQEK 774
            ++  ++EK
Sbjct: 702 EKMWGQEEK 710



 Score =  116 bits (291), Expect = 8e-26
 Identities = 95/300 (31%), Positives = 163/300 (54%), Gaps = 44/300 (14%)

Query: 513 RSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 572
           R  +   + RNT    + K+K  +  E LR  E  +   +  V+E KR      KL+R +
Sbjct: 168 RDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKR------KLERAK 221

Query: 573 RLRKVLQARERVEQM--KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEE 630
            L   +Q     E+M  +EE+ ++ E+K  + +EK  + +EERL E++ K +   +KM  
Sbjct: 222 FLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR-QEERLREQEGKMREQEEKMRR 280

Query: 631 VEAR--------RKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEA----- 677
            E R        R+QE+E R  + L+++EE+ + QE   +K  E++E++R+  E      
Sbjct: 281 QEKRLREQEKELREQEKELREQKKLREQEEQMQEQE---EKMWEQEEKMREQEEKMWRQE 337

Query: 678 KRLAEQREQER-REQERREQERR-----------EQERREQERR-EQERQLAEQERRREQ 724
           +RL EQ +Q R +EQ+ R+QE R           E+  REQE+  EQE ++ E+ER RE+
Sbjct: 338 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER 397

Query: 725 ERLQAERELQEREKALRLQK------EQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
           E+   E E   RE+  ++QK      EQ ++E ++++  E++++L E++  +EQE+K  E
Sbjct: 398 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWE 457



 Score =  116 bits (290), Expect = 1e-25
 Identities = 69/260 (26%), Positives = 154/260 (59%), Gaps = 12/260 (4%)

Query: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR-KVLQARERVEQM 587
           + ++K R + E +  ++E  + + +++ E ++   +E K++ EER+R +  + RE  E M
Sbjct: 349 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETM 408

Query: 588 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEAR----- 642
           +E+++K  +Q+    +++ ++ +++RL E+K K     K  E+ E   +QEE+ R     
Sbjct: 409 REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEM 468

Query: 643 ----RLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER 698
               +  W Q++  E+  Q   Q++K  +QE+ +   + +R+ EQ E+ R ++ER  +++
Sbjct: 469 WGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ-KMWDQEERMWEQDERLREKEERMREQK 527

Query: 699 REQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKE 758
           +  ++ E+ R E++ Q  E++   ++E+++ E  ++EREK +R ++E++ RE EEK +++
Sbjct: 528 KMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMR-EEEEMMREQEEKMQEQ 586

Query: 759 EQQRLAERQLQEEQEKKAKE 778
           E++   + +   EQE+K +E
Sbjct: 587 EEKMREQEEKMWEQEEKMQE 606



 Score =  115 bits (287), Expect = 2e-25
 Identities = 75/259 (28%), Positives = 159/259 (61%), Gaps = 13/259 (5%)

Query: 527 RMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKRE--ERLRKVLQARERV 584
           +M  +EK R++ + +  +EE  + + QK+ + + R  E+ +  RE  ER+R+  +  ++ 
Sbjct: 474 KMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQE 533

Query: 585 EQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 644
           E+M+EEKK Q EQ+    D++ +  +EER+ E + K +   + M E E + +++EE  R 
Sbjct: 534 EKMREEKKTQ-EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMRE 592

Query: 645 R----WLQQEEEERRHQELL-QKKKEEEQERLRKAAEAKRLAEQREQERREQERR--EQE 697
           +    W Q+E+ + + +++  Q++K  EQE   K  E + +  ++E++ +EQE +  EQE
Sbjct: 593 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQE 652

Query: 698 RREQERREQERREQERQLAEQERRREQ-ERLQAERE-LQEREKALRLQKEQLQRELEEKK 755
            + +E+ E+ R ++E+   ++E+ REQ E++Q + E ++E+E+ +R Q+E++  + EEK 
Sbjct: 653 EKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQ-EEKM 711

Query: 756 KKEEQQRLAERQLQEEQEK 774
             +E++   + +++E++E+
Sbjct: 712 WGQEEKMWGQEEMREKEER 730



 Score =  113 bits (282), Expect = 9e-25
 Identities = 74/263 (28%), Positives = 156/263 (59%), Gaps = 21/263 (7%)

Query: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERV---E 585
           + +EK +++ EN+  +EE E  ++Q++ E K +  E+ K++ +E   K+ +  E++   E
Sbjct: 410 EQEEKMQKQEENMWEQEEKEW-QQQRLPEQKEKLWEQEKMQEQEE--KIWEQEEKIRDQE 466

Query: 586 QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR-RKQEEEARRL 644
           +M  ++KK   Q+  +  E     +EE++ +++ K     ++M E + R R++EE  R  
Sbjct: 467 EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQ 526

Query: 645 RWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER--REQERREQE 702
           + + Q+EE+ R ++  Q+++++  ++  K  E +R+ E RE++ RE+E   REQE + QE
Sbjct: 527 KKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRE-REKKMREEEEMMREQEEKMQE 585

Query: 703 RREQERREQERQLAEQERRREQERLQAERE-----------LQEREKALRLQKEQLQREL 751
           + E+ R ++E+   ++E+ +EQE    E+E           +QE+E+ +  Q+E++Q + 
Sbjct: 586 QEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQE 645

Query: 752 EEKKKKEEQQRLAERQLQEEQEK 774
           E+  ++EE+ R  E +++E++EK
Sbjct: 646 EKMWEQEEKMREQEEKMREQEEK 668



 Score =  112 bits (281), Expect = 1e-24
 Identities = 97/439 (22%), Positives = 210/439 (47%), Gaps = 45/439 (10%)

Query: 366 EVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETP 425
           E  +K+  ++K   E+ + +   E E+ E            E        +      E  
Sbjct: 273 EQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEK 332

Query: 426 SAGQQEAKTDQADGPREPPQSAR--RKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPC 483
              Q+E   +Q    RE  Q  R   +R ++Q     ++E+ + ++E    + +      
Sbjct: 333 MWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEE 392

Query: 484 PASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRR 543
              +  + +R    T++  +  M              +       + KE ++QRL   + 
Sbjct: 393 RIREREKKMREEEETMREQEEKMQK------------QEENMWEQEEKEWQQQRLPEQKE 440

Query: 544 K---EEAEQLRRQKV-EEDKRRRLEEVKLKREERLRKVLQARERVEQM--KEEKKKQIEQ 597
           K   +E  Q + +K+ E++++ R +E    +E+++ +  + RE+ +QM  +EEK +  EQ
Sbjct: 441 KLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ 500

Query: 598 KF-----------AQIDEKTEKAK--------EERLAEEKAKKKAAAKKMEEVEARRKQE 638
           K             ++ EK E+ +        EE++ EEK  ++   K  ++ E  R++E
Sbjct: 501 KMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEE 560

Query: 639 EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER 698
               R + +++EEE  R QE   +K +E++E++R+  E     E++ QE+ E+   ++E+
Sbjct: 561 RMREREKKMREEEEMMREQE---EKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEK 617

Query: 699 REQERREQERREQERQLAEQERR---REQERLQAERELQEREKALRLQKEQLQRELEEKK 755
             ++  E + +EQE  + EQE +   +E++  + E +++E+E+ +R Q+E++Q + E+ +
Sbjct: 618 MWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMR 677

Query: 756 KKEEQQRLAERQLQEEQEK 774
           ++EE+ +  E +++E++EK
Sbjct: 678 EQEEKMQGQEEKMREQEEK 696



 Score =  112 bits (280), Expect = 2e-24
 Identities = 99/469 (21%), Positives = 213/469 (45%), Gaps = 43/469 (9%)

Query: 318 LAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKE 377
           L ++   + +QE  +RR  +RL ++  E             L         QK   EQ+E
Sbjct: 264 LREQEGKMREQEEKMRRQEKRLREQEKE-------------LREQEKELREQKKLREQEE 310

Query: 378 PPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQA 437
             +E E     + E         W   +          +      E     Q+E   +Q 
Sbjct: 311 QMQEQEEKMWEQEEKMREQEEKMWRQEER-----LWEQEKQMREQEQKMRDQEERMWEQD 365

Query: 438 DGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLH 497
           +  RE  +  R +    +   ++ EE+ + + E +    +              +R    
Sbjct: 366 ERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEE------------ETMREQEE 413

Query: 498 TVQRNQMLMTPTSAPRSVMKSFIKRNTPL-----RMDPKEKERQRLENLRRKEEAEQLRR 552
            +Q+ +  M          +   ++   L       + +EK  ++ E +R +EE     +
Sbjct: 414 KMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEK 473

Query: 553 QKVEEDKRRRLEEVKLKREERLRKVLQAR-ERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 611
           +   ++K R  E+   ++EE++R   Q   ++ E+M E+ ++  E++    ++K    +E
Sbjct: 474 KMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQE 533

Query: 612 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL 671
           E++ EEK  ++   K  ++ E  R++E    R + +++EEE  R QE   +K +E++E++
Sbjct: 534 EKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE---EKMQEQEEKM 590

Query: 672 RKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR---REQERLQ 728
           R+  E     E++ QE+ E+   ++E+  ++  E + +EQE  + EQE +   +E++  +
Sbjct: 591 REQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWE 650

Query: 729 AERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 777
            E +++E+E+ +R Q+E++Q + EEK +++E++   + +   EQE+K +
Sbjct: 651 QEEKMREQEEKMREQEEKMQGQ-EEKMREQEEKMQGQEEKMREQEEKMR 698



 Score =  110 bits (275), Expect = 6e-24
 Identities = 70/244 (28%), Positives = 142/244 (58%), Gaps = 27/244 (11%)

Query: 532 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 591
           E+ R++ E +R +++  Q   +  EE K +  E+    +EE++R+  + RER ++M+EE+
Sbjct: 514 ERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE 573

Query: 592 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 651
           +   EQ      E+  + +EE++ E++ K     +KM+E E +  ++EE     W Q+EE
Sbjct: 574 EMMREQ------EEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEK---MWEQEEE 624

Query: 652 EERRHQ-ELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR----EQERREQERR-- 704
           ++ + Q E++ +++E+ QE+  K  E +    ++E++ REQE +    E++ REQE +  
Sbjct: 625 DKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQ 684

Query: 705 --EQERREQERQLAEQERRR---------EQERLQAERELQEREKALRLQKEQLQRELEE 753
             E++ REQE ++  QE +          ++E++  + E++E+E+ +R QKE++Q  L E
Sbjct: 685 GQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPE 744

Query: 754 KKKK 757
            +++
Sbjct: 745 HEER 748



 Score =  105 bits (261), Expect = 3e-22
 Identities = 77/261 (29%), Positives = 156/261 (59%), Gaps = 26/261 (9%)

Query: 530 PKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVL-QARERVEQMK 588
           P+ +     E + R+EE  +LR Q   E K R+ EE   ++EERLR+   + RE+ E+M+
Sbjct: 225 PQVQTNTLQEEMWRQEE--ELREQ---EKKIRKQEEKMWRQEERLREQEGKMREQEEKMR 279

Query: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648
            ++K+  EQ+    +++ E  ++++L E++ + +   +KM E E + +++EE     W Q
Sbjct: 280 RQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKM---WRQ 336

Query: 649 QE---EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQE--- 702
           +E   E+E++ +E  QK +++E+   R   + +RL E+ E+ R +++  EQE + QE   
Sbjct: 337 EERLWEQEKQMREQEQKMRDQEE---RMWEQDERLREKEERMREQEKMWEQEEKMQEEER 393

Query: 703 --RREQERREQERQLAEQERR--REQERLQAERELQEREKALRLQKEQL--QRELEEKKK 756
              RE++ RE+E  + EQE +  +++E +  + E + +++ L  QKE+L  Q +++E+++
Sbjct: 394 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE 453

Query: 757 K--EEQQRLAERQLQEEQEKK 775
           K  E+++++ +++    QEKK
Sbjct: 454 KIWEQEEKIRDQEEMWGQEKK 474



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 78/261 (29%), Positives = 139/261 (53%), Gaps = 38/261 (14%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
           KE++   LE  R     E+L+++  E  ++ RL E + K E +L            +KE 
Sbjct: 166 KERDALSLELYRNTITNEELKKKNAELQEKLRLAESE-KSEIQLN-----------VKEL 213

Query: 591 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 650
           K+K    KF     +T   +EE   +E+  ++   K  ++ E   +QEE  R      +E
Sbjct: 214 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 273

Query: 651 EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQER------- 703
           +EE+  ++  +K+  E+++ LR+  + K L EQ++   REQE  EQ + ++E+       
Sbjct: 274 QEEKMRRQ--EKRLREQEKELRE--QEKELREQKKL--REQE--EQMQEQEEKMWEQEEK 325

Query: 704 -REQERR---------EQERQLAEQERR-REQERLQAERELQEREKALRLQKEQLQRELE 752
            REQE +         EQE+Q+ EQE++ R+QE    E++ + REK  R+++++   E E
Sbjct: 326 MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQE 385

Query: 753 EKKKKEEQQRLAERQLQEEQE 773
           EK ++EE+ R  E++++EE+E
Sbjct: 386 EKMQEEERIREREKKMREEEE 406



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 72/286 (25%), Positives = 143/286 (50%), Gaps = 36/286 (12%)

Query: 529 DPKEKERQRLENLRRKEEAEQ-----LRRQKVE--------EDKRRRLEEVKLKREERLR 575
           D K+   Q  E LRR+ EA+      L  QK E        +D  R+ E+  L   + L 
Sbjct: 71  DEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESKDLA 130

Query: 576 -----------KVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAA 624
                      ++ +A   V    ++  + IE+   + D  + +     +  E+ KKK A
Sbjct: 131 GRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNA 190

Query: 625 A--KKMEEVEARRKQ--------EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKA 674
              +K+   E+ + +        + +  R ++L  + +    QE + +++EE +E+ +K 
Sbjct: 191 ELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKI 250

Query: 675 AEAKRLAEQREQERREQERREQERREQERREQER-REQERQLAEQERR-REQERLQAERE 732
            + +    ++E+  REQE + +E+ E+ RR+++R REQE++L EQE+  REQ++L+ + E
Sbjct: 251 RKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEE 310

Query: 733 LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
             + ++    ++E+  RE EEK  ++E++   + +   EQE+K ++
Sbjct: 311 QMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRD 356



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 48/193 (24%), Positives = 101/193 (52%), Gaps = 10/193 (5%)

Query: 520 IKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQ 579
           ++    +  + +EK +++ E +R +EE    + +K++E + +  E+ +   E+     +Q
Sbjct: 569 MREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQ 628

Query: 580 ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 639
            +E +   +EEK ++ E+K  + +EK  + +EE++ E++ K +   +KM E E + + +E
Sbjct: 629 EQEEMMWEQEEKMQEQEEKMWEQEEKM-REQEEKMREQEEKMQGQEEKMREQEEKMQGQE 687

Query: 640 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERR 699
           E  R     ++EE+ R QE    +K   QE      E K   ++  +E+ E+ R ++E+ 
Sbjct: 688 EKMR-----EQEEKMRGQE----EKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKM 738

Query: 700 EQERREQERREQE 712
           ++   E E R  E
Sbjct: 739 QERLPEHEERCSE 751


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score =  115 bits (288), Expect = 2e-25
 Identities = 71/247 (28%), Positives = 148/247 (59%), Gaps = 17/247 (6%)

Query: 527 RMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQ 586
           +M  +E++ Q+ E  +  E+ EQ+R+Q  EE    + E+V+ + E+  ++  Q R++ EQ
Sbjct: 207 QMGEQEEQMQKQEE-QMGEQEEQMRKQ--EEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQ 263

Query: 587 MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 646
           M+E++++  EQ+   + +K +  +EE+  E++ + +      E+ E  R+QEE+ R    
Sbjct: 264 MREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMR------EQEEQMREQEEQMR---- 313

Query: 647 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ 706
            +QEE+ R  +E + K++E+  E+  +  E K    ++E++  EQE + Q++ EQ R+++
Sbjct: 314 -EQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQE 372

Query: 707 ERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAER 766
              EQ R+  EQ R++E++  + E ++ E+++ +  QKEQ++ + E+  +++EQ R  E 
Sbjct: 373 ---EQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEE 429

Query: 767 QLQEEQE 773
            + E++E
Sbjct: 430 HMGEQKE 436



 Score =  111 bits (278), Expect = 3e-24
 Identities = 75/264 (28%), Positives = 158/264 (59%), Gaps = 26/264 (9%)

Query: 531 KEKERQ-RLENLRRKEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQ 586
           +E+E Q R +  + +E+  Q+R Q+    E++ + R +E ++  +E      Q  E+ EQ
Sbjct: 153 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEG-----QMGEQEEQ 207

Query: 587 M--KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 644
           M  +EE+ ++ E++  + +E+  K +E+   +E+  +K   +  ++ E  RKQEE+ R  
Sbjct: 208 MGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMR-- 265

Query: 645 RWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQ------ERREQERREQER 698
              +QEE+ R  +E + K+KE+ ++  +   + +++ EQ EQ      + REQE + +E+
Sbjct: 266 ---EQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQ 322

Query: 699 REQERREQERR-EQERQLAEQER---RREQERLQAERELQEREKALRLQKEQLQRELEEK 754
            EQ  +++E+  EQ+ Q+ EQ+    ++E++  + E ++Q++E+ +R Q+EQ++++ E+ 
Sbjct: 323 EEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQM 382

Query: 755 KKKEEQQRLAERQLQEEQEKKAKE 778
           +K+EEQ R  E Q+ E++E+  ++
Sbjct: 383 RKQEEQMRKQEEQMGEQKEQMGEQ 406



 Score =  107 bits (268), Expect = 4e-23
 Identities = 88/284 (30%), Positives = 162/284 (57%), Gaps = 45/284 (15%)

Query: 531 KEKERQ-RLENLRRKEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQ 586
           +E+E Q R +  + +E+  Q+R Q+    E++ + R +E +++ +E      Q RE+  Q
Sbjct: 132 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG-----QVREQEGQ 186

Query: 587 MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 646
           ++E++ +  EQ+  Q+ E+ E+  E+    E+  +K   +  E+ E  RKQEE+      
Sbjct: 187 VREQEGQMGEQE-GQMGEQEEQMGEQ----EEQMQKQEEQMGEQEEQMRKQEEQMG---- 237

Query: 647 LQQEEEERRHQELLQKKKEE---EQERLRKAAEAKRLAEQ---REQERREQERREQERRE 700
            +QEE+ ++ +E +QK++E+   ++E++R+  E  R  E+   +++E+ EQE +  E+ E
Sbjct: 238 -EQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEE 296

Query: 701 QERREQER-REQERQLAEQERR-REQERLQAERELQ----------------EREKALRL 742
           Q R ++E+ REQE Q+ EQE + REQE    ++E Q                ++E+ +  
Sbjct: 297 QMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGE 356

Query: 743 QKEQLQRELEEKKKKEEQQRLAERQL--QEEQEKKAKEAAGASK 784
           Q+EQ+Q++ E+ +K+EEQ R  E Q+  QEEQ +K +E  G  K
Sbjct: 357 QEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQK 400



 Score =  102 bits (254), Expect = 2e-21
 Identities = 69/257 (26%), Positives = 154/257 (59%), Gaps = 26/257 (10%)

Query: 531 KEKERQ-RLENLRRKEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQ 586
           +E+E Q R +  + +E+  Q+R Q+    E++ + R +E +++ +E      Q RE+  Q
Sbjct: 90  REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG-----QVREQEGQ 144

Query: 587 MKEEKKKQIEQKFAQIDEKTEKAKEE--RLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 644
           ++E++  Q+ ++  Q+ E+  + +E+  ++ E++ + +    ++ E E +  ++E     
Sbjct: 145 VREQEG-QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMG- 202

Query: 645 RWLQQEEEERRHQELLQKKKE---EEQERLRKAAEAKRLAEQREQERREQERREQERREQ 701
              +QEE+    +E +QK++E   E++E++RK  E  ++ EQ EQ ++++E+ +++  + 
Sbjct: 203 ---EQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEE--QMGEQEEQVQKQEEQVQKQEEQM 257

Query: 702 ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 761
            ++E++ REQE Q+ EQE +  +++ Q E+E Q  E     Q+EQ++ + E+ +++EEQ 
Sbjct: 258 RKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGE-----QEEQMREQEEQMREQEEQM 312

Query: 762 RLAERQLQEEQEKKAKE 778
           R  E Q++E++E+  K+
Sbjct: 313 REQEEQMREQEEQMGKQ 329



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 71/264 (26%), Positives = 151/264 (57%), Gaps = 26/264 (9%)

Query: 531 KEKERQ-RLENLRRKEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQ 586
           +E+E Q R +  + +E+  Q+R Q+    E++ + R +E +++ +E      Q RE+  Q
Sbjct: 97  REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG-----QVREQEGQ 151

Query: 587 MKEEKKKQIEQKFAQIDEKTEKAKEE--RLAEEKAKKKAAAKKMEEVEARRKQEEE--AR 642
           ++E++  Q+ ++  Q+ E+  + +E+  ++ E++ + +    +M E E +  ++EE    
Sbjct: 152 VREQEG-QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGE 210

Query: 643 RLRWLQQEEEERRHQELLQKKKEE---EQERLRKAAEAKRLAEQREQERREQERREQERR 699
           +   +Q++EE+   QE   +K+EE   EQE   +  E +   ++ +  ++E++ REQE +
Sbjct: 211 QEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQ 270

Query: 700 EQERREQ-----ERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK 754
            +E+ EQ     E+ EQE Q  EQE +  ++    E +++E+E+ +R Q+EQ++ + E+ 
Sbjct: 271 MREQEEQMLKQKEQTEQEEQTGEQEEQMREQ----EEQMREQEEQMREQEEQMREQEEQM 326

Query: 755 KKKEEQQRLAERQLQEEQEKKAKE 778
            K+EEQ    + Q+ E++E+  K+
Sbjct: 327 GKQEEQMWEQKEQMWEQKEQMWKQ 350



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 76/272 (27%), Positives = 157/272 (57%), Gaps = 24/272 (8%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRR-RLEEVKLKREERLRKVL-QARERVEQMK 588
           KEK  +  E L+  E  +   +  ++E KR+   +++ L +E ++R+   Q RE+  Q++
Sbjct: 10  KEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVR 69

Query: 589 E------EKKKQIEQKFAQIDEKTEKAKEE--RLAEEKAKKKAAAKKMEEVEAR-RKQEE 639
           E      E++ Q+ ++  Q+ E+  + +E+  ++ E++ + +    ++ E E + R+QE 
Sbjct: 70  EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 129

Query: 640 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER--REQE--RRE 695
           + R      +E+E +  ++  Q +++E Q R ++    ++  + REQE   REQE   RE
Sbjct: 130 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 189

Query: 696 QERR--EQE----RREQERREQERQLAEQERR---REQERLQAERELQEREKALRLQKEQ 746
           QE +  EQE     +E++  EQE Q+ +QE +   +E++  + E ++ E+E+ ++ Q+EQ
Sbjct: 190 QEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQ 249

Query: 747 LQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
           +Q++ E+ +K+EEQ R  E Q++E++E+  K+
Sbjct: 250 VQKQEEQMRKQEEQMREQEEQMREQEEQMLKQ 281



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 68/258 (26%), Positives = 153/258 (59%), Gaps = 21/258 (8%)

Query: 531 KEKERQ-RLENLRRKEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQ 586
           +E+E Q R +  + +E+  Q+R Q+    E++ + R +E +++ +E      Q RE+  Q
Sbjct: 69  REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG-----QVREQEGQ 123

Query: 587 MKEEKKKQIEQKFAQIDEKTEKAKEE--RLAEEKAKKKAAAKKMEEVEAR-RKQEEEARR 643
           ++E++  Q+ ++  Q+ E+  + +E+  ++ E++ + +    ++ E E + R+QE + R 
Sbjct: 124 VREQEG-QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 182

Query: 644 LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE-RREQERREQERR--E 700
                +E+E +  ++  Q  ++EEQ       + +++ +Q EQ   +E++ R+QE +  E
Sbjct: 183 QEGQVREQEGQMGEQEGQMGEQEEQ----MGEQEEQMQKQEEQMGEQEEQMRKQEEQMGE 238

Query: 701 QERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 760
           QE + Q++ EQ ++  EQ R++E++  + E +++E+E+ +  QKEQ ++E E+  ++EEQ
Sbjct: 239 QEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQE-EQTGEQEEQ 297

Query: 761 QRLAERQLQEEQEKKAKE 778
            R  E Q++E++E+  ++
Sbjct: 298 MREQEEQMREQEEQMREQ 315



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 74/255 (29%), Positives = 140/255 (54%), Gaps = 18/255 (7%)

Query: 539 ENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQK 598
           E L+ K    Q   Q VE +K     E++L  +E  RK+       +++   ++ Q+ ++
Sbjct: 7   EELKEKNAELQEELQLVETEK----SEIQLHIKELKRKL-----ETDKIPLPQEGQVREQ 57

Query: 599 FAQIDEKTEKAKEE--RLAEEKAKKKAAAKKMEEVEAR-RKQEEEARRLRWLQQEEEERR 655
             Q+ E+  + +E+  ++ E++ + +    ++ E E + R+QE + R      +E+E + 
Sbjct: 58  EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 117

Query: 656 HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER-REQERREQER--REQE 712
            ++  Q +++E Q R ++    ++  + REQE + +E+  Q R +E + REQE   REQE
Sbjct: 118 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 177

Query: 713 RQLAEQERR-REQERLQAERELQ--EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQ 769
            Q+ EQE + REQE    E+E Q  E+E+ +  Q+EQ+Q++ E+  ++EEQ R  E Q+ 
Sbjct: 178 GQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMG 237

Query: 770 EEQEKKAKEAAGASK 784
           E++E+  K+     K
Sbjct: 238 EQEEQVQKQEEQVQK 252



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 69/259 (26%), Positives = 153/259 (59%), Gaps = 23/259 (8%)

Query: 530 PKEKERQRLENLRRKEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQ 586
           P+E + +  E   R++E  Q+R Q+    E++ + R +E +++ +E      Q RE+  Q
Sbjct: 49  PQEGQVREQEGQVREQEG-QVREQEGQVREQEGQVREQEGQVREQEG-----QVREQEGQ 102

Query: 587 MKEEKKKQIEQKFAQIDEKTEKAKEE--RLAEEKAKKKAAAKKMEEVEAR-RKQEEEARR 643
           ++E++  Q+ ++  Q+ E+  + +E+  ++ E++ + +    ++ E E + R+QE + R 
Sbjct: 103 VREQEG-QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 161

Query: 644 LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR--EQERREQERREQ 701
                +E+E +  ++  Q +++E Q R ++    ++  +  EQE +  EQE + Q++ EQ
Sbjct: 162 QEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQ 221

Query: 702 --ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEE 759
             E+ EQ R+ QE Q+ EQE + +++    E ++Q++E+ +R Q+EQ+ RE EE+ +++E
Sbjct: 222 MGEQEEQMRK-QEEQMGEQEEQVQKQ----EEQVQKQEEQMRKQEEQM-REQEEQMREQE 275

Query: 760 QQRLAERQLQEEQEKKAKE 778
           +Q L +++  E++E+  ++
Sbjct: 276 EQMLKQKEQTEQEEQTGEQ 294



 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 58/195 (29%), Positives = 115/195 (58%), Gaps = 18/195 (9%)

Query: 521 KRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR-KVLQ 579
           K+   +R   ++   Q  + L++KE+ EQ  +   +E++ R  EE   ++EE++R +  Q
Sbjct: 259 KQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQ 318

Query: 580 ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 639
            RE+ EQM +++++  EQK    ++K +  K+E   E+  +++   +K E  E  RKQEE
Sbjct: 319 MREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQE---EQMGEQEEQMQKQE--EQVRKQEE 373

Query: 640 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERR 699
           + R+     QEE+ R+ +E ++K++E+  E      + +++ EQ+EQ  REQE +  E++
Sbjct: 374 QMRK-----QEEQMRKQEEQMRKQEEQMGE------QKEQMGEQKEQ-MREQEEQMGEQK 421

Query: 700 EQERREQERREQERQ 714
           EQ R+++E   ++++
Sbjct: 422 EQMRKQEEHMGEQKE 436


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score =  115 bits (287), Expect = 2e-25
 Identities = 96/370 (25%), Positives = 179/370 (48%), Gaps = 21/370 (5%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLE-----DEELQPPRSKTPSSPC 483
           Q E +TD+    R      R++  +++   + ++E+  +     D + +  R++      
Sbjct: 70  QTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERER 129

Query: 484 PASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRR 543
              +     R      QR +         R       ++    R   KE+ER++    RR
Sbjct: 130 ETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERR 189

Query: 544 KEEAEQLRRQKVEEDKRRRLEEVKLKRE-----ERLRKVLQARERVEQMKEEKKKQIEQK 598
           + E ++ +  K E+    R  E + +RE     ER R+  + R+R  + + E++KQ E++
Sbjct: 190 ERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERE 249

Query: 599 FAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQE 658
            A  + +TE+ KE     ++ + +   +K  E +  RK++    R R  +++ E +R +E
Sbjct: 250 RAS-ERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERE 308

Query: 659 LLQ---KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQL 715
             +   +K+E E+ER R+    +     RE+ER E++R+ Q   ++ER  Q  RE  RQ 
Sbjct: 309 RERERNRKRERERERERERERQRETERDREKER-ERKRKRQTEMDRERNRQTGREGRRQ- 366

Query: 716 AEQERRREQER-LQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 774
           AE+ER RE+ER  Q+ RE +ERE+  R +  Q +RE + +K ++ Q+   E + Q E+EK
Sbjct: 367 AERERERERERDRQSAREREERERD-RDRDRQKERERQTEKDRDGQR---ETEKQREREK 422

Query: 775 KAKEAAGASK 784
             +   G  +
Sbjct: 423 DRESERGRER 432



 Score =  105 bits (263), Expect = 1e-22
 Identities = 61/256 (23%), Positives = 140/256 (54%), Gaps = 2/256 (0%)

Query: 521 KRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQA 580
           KR T    D K +ER+R ++  RK +  + R++  E+++ R+ +  + ++ E+ R   + 
Sbjct: 68  KRQTERETDRK-RERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKE 126

Query: 581 RERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE 640
           RER  + + E+ +  +    +  E+   A++ER  +   +++   ++  + E  R++  +
Sbjct: 127 RERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQ 186

Query: 641 ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 700
            RR R  Q+E+E +      ++ +E E+ER  +    ++    RE++R+ +  RE+E++ 
Sbjct: 187 ERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQA 246

Query: 701 QERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKE-E 759
           +  R  ER  +  +  E+ER R+++R + ++E + +    R ++ +  RE E K++++ E
Sbjct: 247 ERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRE 306

Query: 760 QQRLAERQLQEEQEKK 775
           ++R  ER  + E+E++
Sbjct: 307 RERERERNRKRERERE 322



 Score =  101 bits (252), Expect = 3e-21
 Identities = 62/253 (24%), Positives = 135/253 (53%), Gaps = 8/253 (3%)

Query: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKRE---ERLRKVLQARERVE 585
           D  ++ER R +   R+ E  Q  R+   + +RRR ++   KR+   ER R   + RER  
Sbjct: 50  DGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQT 109

Query: 586 QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 645
             + +++++ E+   +  E+  + + ER  + +   +   ++  + E  R+++ +  R R
Sbjct: 110 DRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQR 169

Query: 646 WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE 705
             ++  ++ R +E   K ++E +ER R+  +  +  ++  +  RE+ER  +   E ER+ 
Sbjct: 170 QTERNRQKERERE---KNRQERRERERQREKENKTEDRHSERGRERERERETETETERKR 226

Query: 706 QERREQERQ-LAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA 764
           Q  RE++RQ   E+ER ++ ER +A     ER+K    ++++  R+ + ++K+ E+Q   
Sbjct: 227 QTDRERDRQRKTEREREKQAERERASERETERDKERERERDR-DRDRDRRQKERERQTDR 285

Query: 765 ERQLQEEQEKKAK 777
           +RQ + E++++ +
Sbjct: 286 KRQRRTERDRETE 298



 Score =  101 bits (251), Expect = 4e-21
 Identities = 78/299 (26%), Positives = 155/299 (51%), Gaps = 44/299 (14%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRR----LEEVKLKREERLRKVLQARERVEQ 586
           KE+ER+R E  + + E ++ R ++ E+D+ R+     E  + + +ER R+  + R+R  +
Sbjct: 60  KERERRR-EKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQRE 118

Query: 587 MKEEKKKQIEQKFAQ-----IDEKTEKAKE---ERLAEEKAKKKAAAKKMEEVEARRKQE 638
            +  ++K+ E++  +      D +T+  +E   +R AE++ +++   ++  + E  R++E
Sbjct: 119 KERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKE 178

Query: 639 EE------ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQE 692
            E       RR R  Q+E+E +      ++ +E E+ER  +    ++    RE++R+ + 
Sbjct: 179 REREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKT 238

Query: 693 RREQERREQERREQER---REQERQLAEQERRREQERLQAERELQEREKALRL------- 742
            RE+E++ +  R  ER   R++ER+  E++R R+++R Q ERE Q   K  R        
Sbjct: 239 EREREKQAERERASERETERDKERE-RERDRDRDRDRRQKERERQTDRKRQRRTERDRET 297

Query: 743 -QKEQLQRELE-------------EKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALN 787
            +K + QRE E             E++++ E+QR  ER  ++E+E+K K      +  N
Sbjct: 298 ERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERN 356



 Score =  100 bits (250), Expect = 5e-21
 Identities = 73/258 (28%), Positives = 139/258 (53%), Gaps = 13/258 (5%)

Query: 532 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 591
           E+ R+R      + E E+ R+   E D++R+ E  + K+ ER R   +  ER ++ + E+
Sbjct: 207 ERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERER 266

Query: 592 KKQIE------QKFAQIDEKTEKAKE-ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 644
            +  +      ++  Q D K ++  E +R  E K +++   ++  E   +R++E E  R 
Sbjct: 267 DRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERE 326

Query: 645 RWLQQEEEERRHQELLQKKK---EEEQERLRKAAEAKRLAEQREQERREQERREQERREQ 701
           R  Q+E E  R +E  +K+K   E ++ER R+     R   +RE+ER E+ER  Q  RE+
Sbjct: 327 RERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERER-ERERDRQSARER 385

Query: 702 ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 761
           E RE++R +++RQ  E+ER+ E++R       ++RE+    + E+ +    E++K++ ++
Sbjct: 386 EERERDR-DRDRQ-KERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRE 443

Query: 762 RLAERQLQEEQEKKAKEA 779
           R  ERQ   +  ++ K +
Sbjct: 444 RDRERQTDRQAGRQRKRS 461



 Score =  100 bits (249), Expect = 6e-21
 Identities = 67/260 (25%), Positives = 139/260 (53%), Gaps = 16/260 (6%)

Query: 527 RMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKRE-ERLRKVLQARERVE 585
           R   +E+ R++ +  R  +   + RR+K    KR R  E +  RE ER R+  + R+R  
Sbjct: 58  RQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQR 117

Query: 586 QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 645
           + +  ++K+ E++  +  E+    + +   E + ++ A  ++  + +  R+++ E  R +
Sbjct: 118 EKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQK 177

Query: 646 WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR---EQERREQERREQE 702
              + E E+  QE  +++++ E+E   +   ++R   +RE+ER    E ER+ Q  RE++
Sbjct: 178 ---EREREKNRQERRERERQREKENKTEDRHSER-GRERERERETETETERKRQTDRERD 233

Query: 703 RREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKE---- 758
           R+ +  RE+E+Q AE+ER  E+E  + +   +ER++     + Q +RE +  +K++    
Sbjct: 234 RQRKTEREREKQ-AERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTE 292

Query: 759 ---EQQRLAERQLQEEQEKK 775
              E +R  ERQ + E+E++
Sbjct: 293 RDRETERKRERQRERERERE 312



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 59/236 (25%), Positives = 128/236 (54%), Gaps = 6/236 (2%)

Query: 527 RMDPKEKERQRLENLRRKEEAEQLR--RQKVEEDKRRRLEEVKLKREERLRKVLQAR-ER 583
           R   +E++RQR     R+++AE+ R   ++ E DK R  E  + +  +R +K  + + +R
Sbjct: 226 RQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDR 285

Query: 584 VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 643
             Q + E+ ++ E+K  +  E+  + +  R  E + +++   ++  E E  R++E E +R
Sbjct: 286 KRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKR 345

Query: 644 LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER-REQERREQE 702
            R  + + E  R Q   + +++ E+ER R+    ++ A +RE+  R+++R R++ER  Q 
Sbjct: 346 KRQTEMDRERNR-QTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQT 404

Query: 703 RREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKE-QLQRELEEKKKK 757
            ++++ + +  +  E+E+ RE ER +     +E++K     +E Q  R+   ++K+
Sbjct: 405 EKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKR 460



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 80/339 (23%), Positives = 157/339 (46%), Gaps = 39/339 (11%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
           ++E +TD     RE  +   R R  K+   E + ++  E E  +   +KT        + 
Sbjct: 158 ERERQTD-----RERQRQTERNRQ-KEREREKNRQERRERERQREKENKTEDRHSERGRE 211

Query: 489 VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAE 548
               R      +R +         R   +   K+    R   +E ER +     R  + +
Sbjct: 212 RERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRD 271

Query: 549 QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEK 608
           + RRQK   ++ R+ +  + +R ER R+  + RER  + + E+++           +  +
Sbjct: 272 RDRRQK---ERERQTDRKRQRRTERDRETERKRERQRERERERER----------NRKRE 318

Query: 609 AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ 668
            + ER  E + +++    + +E E +RK++ E  R R  Q   E RR  E   +++E E+
Sbjct: 319 RERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAE---RERERER 375

Query: 669 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 728
           ER R++A        RE+E RE++R    ++E+ER+ ++ R+ +R+  E++R RE++R  
Sbjct: 376 ERDRQSA--------REREERERDRDRDRQKERERQTEKDRDGQRE-TEKQREREKDR-- 424

Query: 729 AERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ 767
                 E E+     +E+ +++  E+ ++ +  R A RQ
Sbjct: 425 ------ESERGRERGREREKQKGRERDRERQTDRQAGRQ 457



 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 52/203 (25%), Positives = 112/203 (55%), Gaps = 11/203 (5%)

Query: 580 ARERVEQMKEEKKKQIEQ--KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ 637
           +R R    +  +++ + Q  K A  D++    ++ER   E+ ++K   ++  + +  R++
Sbjct: 27  SRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKER---ERRREKRQTERETDRKRERRR 83

Query: 638 EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER---REQERR 694
           E++  R R   +E +  R +E  +++ + E++R R+    ++   +RE ER   R ++R+
Sbjct: 84  EKDRHRKRDRHRERQRDREKER-ERQTDRERDRQREKERNRQKERERETEREGERGRDRQ 142

Query: 695 EQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK 754
              +RE+ER+    +E+ERQ  ++ER+R+ ER + +   +E+ +  R ++E+ QRE E K
Sbjct: 143 TDGQRERERQRDAEKERERQ-TDRERQRQTERNRQKEREREKNRQERRERER-QREKENK 200

Query: 755 KKKEEQQRLAERQLQEEQEKKAK 777
            +    +R  ER+ + E E + +
Sbjct: 201 TEDRHSERGRERERERETETETE 223



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 62/298 (20%), Positives = 137/298 (45%), Gaps = 14/298 (4%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLE-------DEELQPPRSKTPSS 481
           +Q  +  Q +  RE  +  RR+R  ++      E++H E       + E +    +   +
Sbjct: 169 RQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQT 228

Query: 482 PCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENL 541
                +  +  R      +R +     T   +   +   +R+     D ++KER+R  + 
Sbjct: 229 DRERDRQRKTEREREKQAERERASERETERDKERER---ERDRDRDRDRRQKERERQTDR 285

Query: 542 RRKEEAEQLRR--QKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKF 599
           +R+   E+ R   +K E  + R  E  + ++ ER R+  + RER  + + +++K+ E+K 
Sbjct: 286 KRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKR 345

Query: 600 AQIDEKTEKAKEE--RLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQ 657
            +  E   +   +  R    +A+++   ++  + ++ R++EE  R     +Q+E ER+ +
Sbjct: 346 KRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTE 405

Query: 658 ELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQL 715
           +    ++E E++R R+         +R +ER +Q+ RE++R  Q  R+  R+ +   L
Sbjct: 406 KDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTL 463



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 52/154 (33%), Positives = 80/154 (51%), Gaps = 15/154 (9%)

Query: 634 RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 693
           R +Q+E  RR    Q E E  R +E     +  E++R RK    +     RE+ER  Q  
Sbjct: 56  RNRQKERERRREKRQTERETDRKRE-----RRREKDRHRKRDRHRERQRDREKERERQTD 110

Query: 694 REQER-REQERREQERREQERQLAEQERRREQERLQAERELQ---EREKALRLQKEQLQR 749
           RE++R RE+ER  Q+ RE+E +   +  R  Q   Q ERE Q   E+E+  +  +E+ QR
Sbjct: 111 RERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRER-QR 169

Query: 750 ELEEKKKKEEQ-----QRLAERQLQEEQEKKAKE 778
           + E  ++KE +     Q   ER+ Q E+E K ++
Sbjct: 170 QTERNRQKEREREKNRQERRERERQREKENKTED 203



 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 39/163 (23%), Positives = 91/163 (55%), Gaps = 7/163 (4%)

Query: 617 EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAE 676
           E+ ++K   ++ E+ +  R+ + +  R R   +  +  RH+E  + +++E + +  +  +
Sbjct: 55  ERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERD 114

Query: 677 AKRLAEQREQERREQERREQERREQERREQERREQERQL-AEQERRREQERLQAERELQE 735
            +R  E+  Q+ RE+E   +  R ++R+   +RE+ERQ  AE+ER R     Q +RE Q 
Sbjct: 115 RQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERER-----QTDRERQR 169

Query: 736 REKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
           + +  R ++ + ++  +E++++ E+QR  E + ++   ++ +E
Sbjct: 170 QTERNRQKEREREKNRQERRER-ERQREKENKTEDRHSERGRE 211



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 44/139 (31%), Positives = 82/139 (58%), Gaps = 3/139 (2%)

Query: 643 RLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER-REQERREQERREQ 701
           R R  Q+E E RR +   +++ + ++ER R+    ++    RE++R RE+ER  Q  RE+
Sbjct: 54  RERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRER 113

Query: 702 ER-REQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 760
           +R RE+ER  Q+ +  E ER  E+ R +     +ERE+    +KE+ ++   E++++ E+
Sbjct: 114 DRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTER 173

Query: 761 QRLAERQLQE-EQEKKAKE 778
            R  ER+ ++  QE++ +E
Sbjct: 174 NRQKEREREKNRQERRERE 192



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 35/122 (28%), Positives = 67/122 (54%), Gaps = 7/122 (5%)

Query: 666 EEQERLRKAAEAKRLAEQREQERREQERREQER------REQERREQERREQERQLAEQE 719
           +E  R R   +A + A+  ++ER  Q+ RE+ R      RE +R+ + RRE++R      
Sbjct: 34  QESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDR 93

Query: 720 RRREQERLQAERELQ-EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
            R  Q   + ERE Q +RE+  + +KE+ +++  E++ + E +R  +RQ   ++E++ + 
Sbjct: 94  HRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQR 153

Query: 779 AA 780
            A
Sbjct: 154 DA 155



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 57/285 (20%), Positives = 102/285 (35%), Gaps = 18/285 (6%)

Query: 360 ERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAA 419
           ER    E   K      E   E E     E E             D E        +   
Sbjct: 190 ERERQREKENKTEDRHSERGRERERERETETETERKR------QTDRERDRQRKTERERE 243

Query: 420 SSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEE-QHLEDEELQPPRSKT 478
              E   A ++E + D+ +  RE  +   R R  K+   + D + Q   + + +  R + 
Sbjct: 244 KQAERERASERETERDK-ERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRE 302

Query: 479 PSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRL 538
                   +     R      +R +     T   R   +   KR     MD   +ER R 
Sbjct: 303 RQRERERERERNRKRERERERERERERQRETERDREKERER-KRKRQTEMD---RERNRQ 358

Query: 539 ENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQK 598
                + +AE+ R ++ E D++   E     REER R   + R++ E+ ++ +K +  Q+
Sbjct: 359 TGREGRRQAERERERERERDRQSARE-----REERERDRDRDRQK-ERERQTEKDRDGQR 412

Query: 599 FAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 643
             +   + EK +E     E+ +++   K  E    R+   +  R+
Sbjct: 413 ETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQ 457



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 39/174 (22%), Positives = 77/174 (44%), Gaps = 19/174 (10%)

Query: 527 RMDPKEKERQR---LENLRRKEEAEQLR---RQK-----VEEDKRRRLEEVKLKREERLR 575
           R   +E+ER+R    ++ R +EE E+ R   RQK      E+D+  + E  K +  E+ R
Sbjct: 365 RQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDR 424

Query: 576 KVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARR 635
           +  + RER  + +++K ++ +++  Q D +  + ++          + A   + + +  R
Sbjct: 425 ESERGRERGREREKQKGRERDRE-RQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNR 483

Query: 636 KQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAK---RLAEQREQ 686
                 R +RW    E+ +         +  +  R R A   +   RL E+R Q
Sbjct: 484 ----PTRGIRWKSSPEDPKAASTRFPWGRPAKASRGRVAGRRRWEPRLGEKRGQ 533



 Score = 35.8 bits (81), Expect = 0.19
 Identities = 21/99 (21%), Positives = 50/99 (50%), Gaps = 13/99 (13%)

Query: 698 RREQERREQERR------------EQERQLAEQERRREQERLQAERELQEREKALRLQKE 745
           RR    +E  RR            +   +  ++ER R +E+ Q ERE  +R++  R +K+
Sbjct: 28  RRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERE-TDRKRERRREKD 86

Query: 746 QLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 784
           + ++    ++++ ++++  ERQ   E++++ ++     K
Sbjct: 87  RHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQK 125


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score =  114 bits (284), Expect = 5e-25
 Identities = 139/550 (25%), Positives = 232/550 (42%), Gaps = 121/550 (22%)

Query: 242 DPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFS------TPTG 295
           DP G+G   GR+ + L           S A P  P R    +P+ P + +       P G
Sbjct: 329 DP-GRGPTWGRAGASLARGPQPDRTHPSAAVPVCP-RSASASPLTPCSVTRSVHRCAPAG 386

Query: 296 SRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIIC 355
            R +    R  P A  SP+P     + S V K+E   +       ++  +E +A  R   
Sbjct: 387 ERGE----RRKPNAGGSPAPVRRRPEASPVQKKEKKDKE------RENEKEKSALAR--- 433

Query: 356 HSYLERLLNVEVPQKVGSEQK---EPPEEAEPVAAAEPEVPENNGNNSW---------PH 403
               ER L            +       E  P + A P  P    + SW         P 
Sbjct: 434 ----ERSLKKRQSLPASPRARLSASTASELSPKSKARPSSP----STSWHRPASPCPSPG 485

Query: 404 NDTEIANSTPNPKPAASSPETPSAGQQEAK-TDQADGPREPPQSARRKRSYKQAVSELDE 462
               +    P+P+   +SP+     ++EAK +  A GP +  QS RR  + K++ +    
Sbjct: 486 PGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPAS- 544

Query: 463 EQHLEDEELQPPRSKTPS-SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK 521
                     P  S  PS +P P  K   P  T             PT A  +V+ S   
Sbjct: 545 ----------PAPSPAPSPTPAPPQKEQPPAET-------------PTDA--AVLTS--- 576

Query: 522 RNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR 581
              P    P     + +     +EEA +L  +K      RR                QAR
Sbjct: 577 ---PPAPAPPVTPSKPMAGTTDREEATRLLAEK------RR----------------QAR 611

Query: 582 ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA 641
           E+ E+ ++E++ Q E             +++R+ EE+  ++A A+   E EARR++E+EA
Sbjct: 612 EQREREEQERRLQAE-------------RDKRMREEQLAREAEARAEREAEARRREEQEA 658

Query: 642 RRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ 701
           R     +QEE+ER     LQK+KEE + R R+ AE +RL  ++  +++EQER+E+ +R +
Sbjct: 659 REKAQAEQEEQER-----LQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLE 713

Query: 702 ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKK---KE 758
           E  ++ R+    +++E +++++ +   A     E  KA+  +   LQ+E  +K++   +E
Sbjct: 714 EIMKRTRKS---EVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQE 770

Query: 759 EQQRLAERQL 768
            Q  L  ++L
Sbjct: 771 PQWSLPSKEL 780



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 92/393 (23%), Positives = 157/393 (39%), Gaps = 40/393 (10%)

Query: 410 NSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
           N+  +P P    PE     ++E K  + +  +E    AR +   K+          L   
Sbjct: 395 NAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSAS 454

Query: 470 ---ELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPL 526
              EL P     PSSP               T         P+  P   +        P 
Sbjct: 455 TASELSPKSKARPSSPS--------------TSWHRPASPCPSPGPGHTLP-------PK 493

Query: 527 RMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQ 586
              P+         +RRKEEA++       EDK +       ++E        A      
Sbjct: 494 PPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKES----AAPASPAPSP 549

Query: 587 MKEEKKKQIEQKFAQIDEKTEKA---KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 643
                    +++    +  T+ A        A      K  A   +  EA R   E+ R+
Sbjct: 550 APSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQ 609

Query: 644 LR-WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQE 702
            R   ++EE+ERR Q    K+  EEQ  L + AEA+   E   + R EQE RE+ + EQE
Sbjct: 610 AREQREREEQERRLQAERDKRMREEQ--LAREAEARAEREAEARRREEQEAREKAQAEQE 667

Query: 703 RREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQR 762
            +E+ ++++E   A      E++RL+ E+  Q++E+    ++++ ++ LEE  K+  +  
Sbjct: 668 EQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQ----ERQERRKRLEEIMKRTRKSE 723

Query: 763 LAERQLQEEQEKKAKEAAGASKALNVTVDVQSP 795
           ++E   +++Q+ K   A G+S      V+ +SP
Sbjct: 724 VSE--TKQKQDSKEANANGSSPEPVKAVEARSP 754



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 58/215 (26%), Positives = 92/215 (42%), Gaps = 26/215 (12%)

Query: 408 IANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLE 467
           +A + P P+P+     +P      A     D P + P + +   S KQ   E +      
Sbjct: 18  VARTPPEPRPSPEGDPSPPPPPMSALVP--DTPPDTPPAMKNATSSKQLPLEPESPSGQV 75

Query: 468 DEELQPPRSKTPSS------PCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRS---VMKS 518
                PP+ ++PSS      P P +   R  R       R     +PT+ P S     K 
Sbjct: 76  GPRPAPPQEESPSSEAKSRGPTPPAMGPRDARP-----PRRSSQPSPTAVPASDSPPTKQ 130

Query: 519 FIKRNTPLRMDPKEKERQRLENLR-------RKEEAEQLRRQKVEEDKRRRLEEVKLKRE 571
            +K+        KE+  +R + L         KEE  +  R+K  +++RRRLEE +LK E
Sbjct: 131 EVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAE 190

Query: 572 ERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKT 606
           +R R  L+ R+R  Q  E+ K++ E    +  +KT
Sbjct: 191 QR-RAALEERQR--QKLEKNKERYEAAIQRSVKKT 222



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 31/94 (32%), Positives = 56/94 (59%), Gaps = 8/94 (8%)

Query: 704 REQERREQERQLAEQERRREQERLQAERE---LQEREKALRLQKEQLQ---RELEEKKKK 757
           +++ ++  ER    +ERR E+ +  A ++   L++ EKA  L+++QLQ   R LEE++ K
Sbjct: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188

Query: 758 EEQQR--LAERQLQEEQEKKAKEAAGASKALNVT 789
            EQ+R  L ERQ Q+ ++ K +  A   +++  T
Sbjct: 189 AEQRRAALEERQRQKLEKNKERYEAAIQRSVKKT 222



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 29/94 (30%), Positives = 57/94 (60%), Gaps = 5/94 (5%)

Query: 668 QERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERL 727
           ++ ++KA E  +LA++R +ER +     ++    E+ E+ +  +E+QL E+ RR E++RL
Sbjct: 129 KQEVKKAGERHKLAKERREERAKY-LAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187

Query: 728 QAERE---LQEREK-ALRLQKEQLQRELEEKKKK 757
           +AE+    L+ER++  L   KE+ +  ++   KK
Sbjct: 188 KAEQRRAALEERQRQKLEKNKERYEAAIQRSVKK 221



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 51/228 (22%), Positives = 92/228 (40%), Gaps = 34/228 (14%)

Query: 368 PQKVGSEQKEPPEEAEPVAAAEPEVPENNG---NNSWPHNDTEIANSTPN----PKPAAS 420
           P+   S + +P     P++A  P+ P +      N+       +   +P+    P+PA  
Sbjct: 23  PEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPP 82

Query: 421 SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS 480
             E+PS+   EAK+     P   P+ AR  R                    QP  +  P+
Sbjct: 83  QEESPSS---EAKSRGPTPPAMGPRDARPPR-----------------RSSQPSPTAVPA 122

Query: 481 SPCPASKVVRPLRTFLHTV--QRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRL 538
           S  P +K         H +  +R +      +A ++V     ++   LR    ++ R+RL
Sbjct: 123 SDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRL 182

Query: 539 ENLRRKEEA-----EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR 581
           E  R K E      E+ +RQK+E++K R    ++   ++   ++ Q R
Sbjct: 183 EEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 34/127 (26%), Positives = 62/127 (48%), Gaps = 25/127 (19%)

Query: 596 EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 655
           +Q+  +  E+ + AKE R  EE+AK  AA K +                 WL++EE+ + 
Sbjct: 129 KQEVKKAGERHKLAKERR--EERAKYLAAKKAV-----------------WLEKEEKAKA 169

Query: 656 HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQL 715
            +E      ++ QER R+  E +  AEQR     E++R++ E+ ++      +R  ++  
Sbjct: 170 LRE------KQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTW 223

Query: 716 AEQERRR 722
           AE  ++R
Sbjct: 224 AEIRQQR 230



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 28/122 (22%), Positives = 57/122 (46%), Gaps = 1/122 (0%)

Query: 610 KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE-EQ 668
           ++ R     ++    A    +    +++ ++A     L +E  E R + L  KK    E+
Sbjct: 104 RDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEK 163

Query: 669 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 728
           E   KA   K+L E+R +   ++ + EQ R   E R++++ E+ ++  E   +R  ++  
Sbjct: 164 EEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTW 223

Query: 729 AE 730
           AE
Sbjct: 224 AE 225



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 13/115 (11%)

Query: 648 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 707
           +QE ++   +  L K++ EE+ +   A +A  L    E+E + +  RE++ +E+ RR +E
Sbjct: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWL----EKEEKAKALREKQLQERRRRLEE 184

Query: 708 RREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQR 762
           +R     L  ++RR   E    ER+ Q+ EK     +  +QR +++   +  QQR
Sbjct: 185 QR-----LKAEQRRAALE----ERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 28/104 (26%), Positives = 53/104 (50%), Gaps = 3/104 (2%)

Query: 593 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 652
           KQ  +K  +  +  ++ +EER     AKK    +K E+ +A R+++ + RR R    EE+
Sbjct: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRR---LEEQ 185

Query: 653 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQ 696
             + ++     +E ++++L K  E    A QR  ++   E R+Q
Sbjct: 186 RLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229



 Score = 35.4 bits (80), Expect = 0.24
 Identities = 96/452 (21%), Positives = 143/452 (31%), Gaps = 99/452 (21%)

Query: 66  RKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVT 125
           R++   S VQ + +    R     K +S+    R L+ + S+                 +
Sbjct: 404 RRRPEASPVQKKEKKDKER--ENEKEKSALARERSLKKRQSLP---------------AS 446

Query: 126 RAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQ 185
             A  +A+    L+  S   P SP+    +P                             
Sbjct: 447 PRARLSASTASELSPKSKARPSSPSTSWHRP----------------------------- 477

Query: 186 LMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKG 245
                P P   SP P     P     P+    +   K + R  E    S   A P+D   
Sbjct: 478 ---ASPCP---SPGPGHTLPPKP---PSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQ 528

Query: 246 QGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRT-DSQSVR 304
                         A  +P P  SP  P  P +E+  A        TPT +    S    
Sbjct: 529 SKRRASNEKESAAPASPAPSPAPSPT-PAPPQKEQPPA-------ETPTDAAVLTSPPAP 580

Query: 305 HSPIAPSSP---------SPQVLAQKYSLVAKQ---ESVVRRASRRLAKKTAEEP---AA 349
             P+ PS P         + ++LA+K     +Q   E   RR      K+  EE     A
Sbjct: 581 APPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREA 640

Query: 350 SGRIICHSYLERLLNVEVPQKVGSEQKE------PPEEAEPVAAAEPEVPENNGNNSWPH 403
             R    +   R    E  +K  +EQ+E        EEAE  +  E E         +  
Sbjct: 641 EARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQ 700

Query: 404 NDTEIANSTPN----PKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRS---YKQA 456
            + E            K    S  + +  +Q++K   A+G    P  A   RS    K+A
Sbjct: 701 QEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEA 760

Query: 457 VSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
           V +       E+   Q P+   PS   PAS V
Sbjct: 761 VQK-------EEPIPQEPQWSLPSKELPASLV 785



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 28/114 (24%), Positives = 52/114 (45%), Gaps = 10/114 (8%)

Query: 38  QEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSR--RKSRSSQ 95
           QEE ER+  ++  +E E   +  +++ R ++ +    Q++ R   R+RL    +++R S+
Sbjct: 666 QEEQERL--QKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSE 723

Query: 96  LSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATMALAAPSSPTPESP 149
           +S  + + +DS E  A     NGS    V    A +            P P+ P
Sbjct: 724 VSETK-QKQDSKEANA-----NGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEP 771



 Score = 31.6 bits (70), Expect = 3.5
 Identities = 42/162 (25%), Positives = 58/162 (35%), Gaps = 34/162 (20%)

Query: 189 TEPLPRTLSPT--PASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQ 246
           T P PR  SP   P+    P S  +P +  ++ P    A   + + +      P+ P GQ
Sbjct: 21  TPPEPRP-SPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLE-----PESPSGQ 74

Query: 247 GVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHS 306
                             GPR +P   +SP  E       P     P     D++  R S
Sbjct: 75  -----------------VGPRPAPPQEESPSSEAKSRGPTP-----PAMGPRDARPPRRS 112

Query: 307 PIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPA 348
               S PSP  +    S   KQE        +LAK+  EE A
Sbjct: 113 ----SQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERA 150


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score =  112 bits (280), Expect = 2e-24
 Identities = 82/266 (30%), Positives = 146/266 (54%), Gaps = 36/266 (13%)

Query: 517 KSFIKRNTPLRM-------DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLK 569
           ++ +K NT L+M        P  +   + E   R+ E E  +  K E +  R+ E    +
Sbjct: 8   RAAVKLNTELQMVSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKE----R 63

Query: 570 REERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKME 629
           RE   RK    RER ++ K E+ K+        ++K E+ KEER  E K +++    K  
Sbjct: 64  REREKRK----REREKERKRERGKK--------EKKGERKKEER--ERKKRRREKENKEG 109

Query: 630 EVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR 689
           E + +RK++E+  R R  ++ +E  R +E   +K+EE +ER RK        E+RE+ER 
Sbjct: 110 EEKEKRKKKEKKERGRTSKEGKERERKEE---RKREERKERERKK-------EEREKERE 159

Query: 690 EQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQR 749
            +ER+++ER++   +E+ER+E+ER+  ++  R  +ER + ERE +ER +  + +K++ +R
Sbjct: 160 RKERKKRERKQVGEKEEERKEKERKERKKRERNRKER-KKERERKERRERKKERKKKEER 218

Query: 750 ELEEKKKKEEQQRLAERQLQEEQEKK 775
           + E +K ++   R  ER  +E +E+K
Sbjct: 219 KKERQKDRQTNWREKERGKRERKERK 244



 Score =  111 bits (277), Expect = 4e-24
 Identities = 71/228 (31%), Positives = 136/228 (59%), Gaps = 23/228 (10%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
           +E+ER+       K+E E  R+++  E ++R+ E  K ++ ER +K        E+  E 
Sbjct: 39  REREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKK--------EKKGER 90

Query: 591 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 650
           KK++ E+K      K  + KE +  EEK K+K    K E+ E  R  +E   R R  +++
Sbjct: 91  KKEERERK------KRRREKENKEGEEKEKRK----KKEKKERGRTSKEGKERERKEERK 140

Query: 651 EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE--QER 708
            EER+ +E  ++++E+E+ER  +    ++   ++E+ER+E+ER+E+++RE+ R+E  +ER
Sbjct: 141 REERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKER 200

Query: 709 REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKK 756
             +ER+  ++ER++++ER   ++E Q+  +    +KE+ +RE +E+KK
Sbjct: 201 ERKERRERKKERKKKEER---KKERQKDRQTNWREKERGKRERKERKK 245



 Score =  110 bits (276), Expect = 5e-24
 Identities = 70/206 (33%), Positives = 127/206 (61%), Gaps = 12/206 (5%)

Query: 578 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ 637
           ++ RER  + ++E KK+ E +  +   + EK K ER   EK +K+   KK  E +  RK+
Sbjct: 38  IREREREIETRKEGKKERESERKKERREREKRKRER---EKERKRERGKK--EKKGERKK 92

Query: 638 EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 697
           EE  R+ R  ++E +E   +E  +KK+++E+ R  K  + +   E+R++E R++  R++E
Sbjct: 93  EERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE 152

Query: 698 RREQERREQERREQER-QLAEQERRREQ----ERLQAERELQEREKALRLQKEQLQRELE 752
            RE+ER  +ER+++ER Q+ E+E  R++    ER + ER  +ER+K  R +KE+ +R+ E
Sbjct: 153 EREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKE-RERKERRERKKE 211

Query: 753 EKKKKE-EQQRLAERQLQEEQEKKAK 777
            KKK+E +++R  +RQ    ++++ K
Sbjct: 212 RKKKEERKKERQKDRQTNWREKERGK 237



 Score =  108 bits (271), Expect = 2e-23
 Identities = 70/207 (33%), Positives = 132/207 (63%), Gaps = 22/207 (10%)

Query: 572 ERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV 631
           ER R++   +E  ++ + E+KK+  ++        EK K ER   EK +K+   KK  E 
Sbjct: 40  EREREIETRKEGKKERESERKKERRER--------EKRKRER---EKERKRERGKK--EK 86

Query: 632 EARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQ 691
           +  RK+EE  R+ R  ++E+E +  +E  ++KK+E++ER R + E K    +R++ER+ +
Sbjct: 87  KGERKKEERERKKR--RREKENKEGEEKEKRKKKEKKERGRTSKEGKE--RERKEERKRE 142

Query: 692 ERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQREL 751
           ER+E+ER+++E RE+ER  +ER+  E+++  E+E  + E+E +ER+K  R +KE+     
Sbjct: 143 ERKERERKKEE-REKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKER----K 197

Query: 752 EEKKKKEEQQRLAERQLQEEQEKKAKE 778
           +E+++KE ++R  ER+ +EE++K+ ++
Sbjct: 198 KERERKERRERKKERKKKEERKKERQK 224



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 45/160 (28%), Positives = 101/160 (63%), Gaps = 12/160 (7%)

Query: 630 EVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER- 688
           E+  R ++ E  +  +  ++ E ++  +E  ++K+E E+ER R+  + ++  E++++ER 
Sbjct: 37  EIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERE 96

Query: 689 REQERREQERREQERREQERREQERQLA----------EQERRREQERLQAERELQEREK 738
           R++ RRE+E +E E +E+ +++++++             +E R+ +ER + ER+ +EREK
Sbjct: 97  RKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREK 156

Query: 739 ALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
             R +KE+ +RE ++  +KEE+++  ER+ ++++E+  KE
Sbjct: 157 E-RERKERKKRERKQVGEKEEERKEKERKERKKRERNRKE 195


>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
           theta, 150/170kDa [Homo sapiens]
          Length = 1382

 Score =  111 bits (278), Expect = 3e-24
 Identities = 99/371 (26%), Positives = 182/371 (49%), Gaps = 64/371 (17%)

Query: 464 QHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRN 523
           Q +  E+++   +   S    A +V++P        +++Q+ +T      + +K+  K +
Sbjct: 512 QSMPSEQIRNQLTAMSSVLAKALEVIKPAHILQEKEEQHQLAVT------AYLKNSRKEH 565

Query: 524 TPL--RMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR---KVL 578
             +  R    E+ ++RLE+L  + E E+L +++ E  K R+ EE +L++E + R   ++L
Sbjct: 566 QRILARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERIL 625

Query: 579 QARERV------EQMKEEKKKQIEQK-FAQID--------------------EKTEKAKE 611
           Q  E++      E++++ KK ++  K F  ID                    EK +K  +
Sbjct: 626 QEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQ 685

Query: 612 ERLA--EEKAKKKAAAKKMEEVEARRKQEEEARRLR---WLQQEEEERRHQELLQKKKEE 666
           ERL   E+K      AK++EE+   +   EE R      W QQEEE     +L ++K  E
Sbjct: 686 ERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTMQLEREKALE 745

Query: 667 EQERLRKAAEAKRL----------------AEQREQERREQERREQERREQERREQERRE 710
            + R+ +  E + L                 +Q E+   E+     E R+++R+E+ R  
Sbjct: 746 HKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRIT 805

Query: 711 QERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQ- 769
             R+  E+E+RR +E++  ERE  ERE+A R ++E+  RE +E+ KK E+    +RQ + 
Sbjct: 806 YYREKEEEEQRRAEEQMLKERE--ERERAERAKREEELREYQERVKKLEEVERKKRQREL 863

Query: 770 --EEQEKKAKE 778
             EE+E++ +E
Sbjct: 864 EIEERERRREE 874



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 72/289 (24%), Positives = 138/289 (47%), Gaps = 51/289 (17%)

Query: 525 PLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER- 583
           PL     E++R +  +L  ++E E++   ++E +K        L+ + R+ ++L+ R+  
Sbjct: 708 PLIKSAYEEQRIKDMDLWEQQEEERITTMQLEREKA-------LEHKNRMSRMLEDRDLF 760

Query: 584 VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 643
           V ++K  ++   E+K  Q +E+  + +  RL E K ++K   ++      R K+EEE RR
Sbjct: 761 VMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRK---EERRITYYREKEEEEQRR 817

Query: 644 LR-WLQQEEEERRHQELLQKKKE--EEQERLRKAAEAKRLAEQREQERREQERREQERR- 699
               + +E EER   E  ++++E  E QER++K  E +R   QRE E  E+ERR +E R 
Sbjct: 818 AEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEIEERERRREEERR 877

Query: 700 ----------------------------EQERR----EQERREQERQLAEQERRREQERL 727
                                       + E R    E+E R  E +  ++  RR++ER 
Sbjct: 878 LGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPPEKEWRRGEGRDEDRSHRRDEERP 937

Query: 728 QAERELQEREKALRLQKEQLQR----ELEEKKKKEEQQRLAERQLQEEQ 772
           +   + ++RE +LR   +++ R    +    ++  E+ R + R   +++
Sbjct: 938 RRLGDDEDREPSLRPDDDRVPRRGMDDDRGPRRGPEEDRFSRRGADDDR 986



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 38/187 (20%), Positives = 79/187 (42%), Gaps = 21/187 (11%)

Query: 607  EKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE 666
            EKA+EE     +  + +  ++ +    R K+ +   + R    ++ ER         +E+
Sbjct: 1182 EKAREESWGPPRESRPSEEREWD----REKERDRDNQDREENDKDPERERDRERDVDRED 1237

Query: 667  EQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERRE--QERQLAEQERRREQ 724
               R R     +R   +     R+  RR+   R+  RRE++ R   +ER+    +R R  
Sbjct: 1238 RFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRG 1297

Query: 725  ERLQAERE---------------LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQ 769
              L++ERE               ++ER+   R+    L R+ E  + +E +    +   +
Sbjct: 1298 PPLRSEREEVSSWRRADDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEKEKASWR 1357

Query: 770  EEQEKKA 776
             E+++++
Sbjct: 1358 AEKDRES 1364



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 37/135 (27%), Positives = 70/135 (51%), Gaps = 23/135 (17%)

Query: 659 LLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQ 718
           +LQ+K+E+ Q  +    +  R   QR   RR+     +ER E    ++E+ E E      
Sbjct: 542 ILQEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELE------ 595

Query: 719 ERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK---EEQQRLAERQLQE--EQE 773
                    Q E ELQ+  KA   ++E+L++E +E++K+   +E +++ ++ ++E  EQ 
Sbjct: 596 ---------QREAELQKVRKA---EEERLRQEAKEREKERILQEHEQIKKKTVRERLEQI 643

Query: 774 KKAKEAAGASKALNV 788
           KK +  A A K +++
Sbjct: 644 KKTELGAKAFKDIDI 658



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 44/198 (22%), Positives = 89/198 (44%), Gaps = 12/198 (6%)

Query: 531  KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
            +EKE+ R E+     E+     ++ + +K R  +     REE  +   + R+R      E
Sbjct: 1179 REKEKAREESWGPPRESRPSEEREWDREKER--DRDNQDREENDKDPERERDR------E 1230

Query: 591  KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKME-EVEARRKQEEEARRLRWLQQ 649
            +    E +F +   + E       AEE +  + ++++ + + + RR++ ++ R LR  + 
Sbjct: 1231 RDVDREDRFRR--PRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRD 1288

Query: 650  EEEERRHQELLQKKKEEEQERLRKAAEAK-RLAEQREQERREQERREQERREQERREQER 708
              ++R  +    + + EE    R+A + K    E+R+  RR         RE++R  +  
Sbjct: 1289 LRDDRDRRGPPLRSEREEVSSWRRADDRKDDRVEERDPPRRVPPPALSRDRERDRDRERE 1348

Query: 709  REQERQLAEQERRREQER 726
             E+E+     E+ RE  R
Sbjct: 1349 GEKEKASWRAEKDRESLR 1366



 Score = 37.4 bits (85), Expect = 0.064
 Identities = 48/198 (24%), Positives = 85/198 (42%), Gaps = 29/198 (14%)

Query: 571  EERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEE 630
            EER     + R+R  Q +EE  K  E+   + D + +  +E+R    +          +E
Sbjct: 1199 EEREWDREKERDRDNQDREENDKDPER---ERDRERDVDREDRFRRPR----------DE 1245

Query: 631  VEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE--- 687
               RR   EE+   R     +  RR       ++ E  +R R   E + L + R++    
Sbjct: 1246 GGWRRGPAEESSSWR-----DSSRRDDRDRDDRRRERDDR-RDLRERRDLRDDRDRRGPP 1299

Query: 688  -RREQERREQERREQERREQ--ERREQERQLAEQERRREQER-LQAERELQEREKALRLQ 743
             R E+E     RR  +R++   E R+  R++      R++ER    ERE ++ + + R +
Sbjct: 1300 LRSEREEVSSWRRADDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAE 1359

Query: 744  KEQLQRELEEKKKKEEQQ 761
            K+   RE   + K E  +
Sbjct: 1360 KD---RESLRRTKNETDE 1374



 Score = 37.0 bits (84), Expect = 0.084
 Identities = 24/139 (17%), Positives = 60/139 (43%), Gaps = 11/139 (7%)

Query: 636  KQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE 695
            +++E+AR   W    E     +    ++KE +++            + RE+  ++ ER  
Sbjct: 1179 REKEKAREESWGPPRESRPSEEREWDREKERDRDN-----------QDREENDKDPERER 1227

Query: 696  QERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKK 755
               R+ +R ++ RR ++     +    E    +      +R++  R ++   +R+L E++
Sbjct: 1228 DRERDVDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERR 1287

Query: 756  KKEEQQRLAERQLQEEQEK 774
               + +      L+ E+E+
Sbjct: 1288 DLRDDRDRRGPPLRSEREE 1306


>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 523

 Score =  110 bits (274), Expect = 8e-24
 Identities = 113/385 (29%), Positives = 192/385 (49%), Gaps = 49/385 (12%)

Query: 409 ANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLED 468
           A +    K   SSP+T ++G   +  D A G             Y +  +     + LE 
Sbjct: 42  AGANRKKKINGSSPDTATSGGYHSPGDSATG------------IYGEGRASSTTLEDLES 89

Query: 469 EELQPPRSKTPSSPCPASKVVRPLRTFLHTV--QRNQMLMTPTSAPRSVMKSFIKRNTPL 526
           +  Q       SS    S++   + + + T   ++   +       RS+ K   +   PL
Sbjct: 90  Q-YQELAVALDSSSAIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPL 148

Query: 527 RMDP-----KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQA- 580
             +P     K ++ Q   N  RKE     R+ + E +  + L  +  ++EERLR+  +  
Sbjct: 149 APEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERL 208

Query: 581 RERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE 640
           RE+ E+++E++++  EQ      E+  + +EERL E++ +     +++ E E R  ++EE
Sbjct: 209 REQEERLREQEERLCEQ------EERLREQEERLREQEERLCEQEERLREHEERLCEQEE 262

Query: 641 ARRLRWLQQEEEERRHQELLQKKKE---EEQERLRKAAEAKRLAEQREQERREQERR--- 694
               R  +QEE  R  +E L +++E   E++ERLR+  E  RL EQ E+  REQE R   
Sbjct: 263 ----RLCEQEERLREQEERLHEQEERLCEQEERLREQEE--RLCEQ-EERLREQEERLCE 315

Query: 695 -EQERREQERR--EQERRE-QERQLAEQERRREQERLQAERE-LQEREKALRLQKEQLQR 749
            E+  REQE R  EQE+   QER L E E+  EQER Q E+E L ERE+ L    E+++ 
Sbjct: 316 QEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLL----EEVEE 371

Query: 750 ELEEKKKKEEQQRLAERQLQEEQEK 774
            LE+++ +++ +RL +++  +E E+
Sbjct: 372 LLEQERLRQQDERLWQQETLQELER 396



 Score =  103 bits (257), Expect = 7e-22
 Identities = 101/362 (27%), Positives = 176/362 (48%), Gaps = 36/362 (9%)

Query: 466 LEDEELQPPRSKTPSSPCPASKV---VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKR 522
           L+++  +P   + P+ P    ++      LR  L +V R            + M S + R
Sbjct: 140 LKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQ----AEVENNQMLSLLNR 195

Query: 523 NTPLRM-DPKEKERQRLENLRRKEE--AEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQ 579
               R+ + +E+ R++ E LR +EE   EQ  R + +E++ R  EE   ++EERLR    
Sbjct: 196 RQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLR---- 251

Query: 580 ARERVEQMKEEKKKQIEQKFAQIDEKTEKA--KEERLAEEKAKKKAAAKKMEEVEARRKQ 637
             E  E++ E++++  EQ+  ++ E+ E+   +EERL E++ + +   +++ E E R ++
Sbjct: 252 --EHEERLCEQEERLCEQE-ERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLRE 308

Query: 638 EEEARRLRWLQQEEEERRHQE-LLQKKKEEEQERLRKAAEAKRLAEQREQERRE------ 690
           +EE    R  +QEE  R  +E L +++K   QERL +  E K L ++R QE +E      
Sbjct: 309 QEE----RLCEQEERLREQEERLCEQEKLPGQERLLEEVE-KLLEQERRQEEQERLLERE 363

Query: 691 ---QERREQERREQERREQERREQERQLAEQERRREQERL--QAERELQEREKALRLQKE 745
              +E  E   +E+ R++ ER  Q+  L E ER RE ER+       L E+    R   E
Sbjct: 364 RLLEEVEELLEQERLRQQDERLWQQETLQELERLRELERMLELGWEALYEQRAEPRSGFE 423

Query: 746 QLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQ 805
           +L  E +   + E+Q +  ++    E+ + ++ AA A       V   +  C     TPQ
Sbjct: 424 ELNNENKSTLQLEQQVKELKKSGGAEEPRGSESAAAARPVAGAPVPQGAWMCGQAGWTPQ 483

Query: 806 GH 807
            H
Sbjct: 484 EH 485



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 83/259 (32%), Positives = 135/259 (52%), Gaps = 38/259 (14%)

Query: 557 EDKRRRLEEVKLKREERLRKVLQARERVEQM----KEEKKKQIE--QKFAQIDEKTEKAK 610
           ED   + +E+ +  +     + Q  E +  +    KEEKK +I   QK  +   K +   
Sbjct: 85  EDLESQYQELAVALDSSSAIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQT 144

Query: 611 EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE---- 666
            E LA E     +  +++++     ++E E+   R LQ E E  +   LL +++EE    
Sbjct: 145 AEPLAPEPPAGPSKVEQLQDETNHLRKELESVG-RQLQAEVENNQMLSLLNRRQEERLRE 203

Query: 667 EQERLRKAAEA-----KRLAEQREQERREQER-REQERR--EQERR---------EQERR 709
           ++ERLR+  E      +RL EQ E+ R ++ER REQE R  EQE R         EQE R
Sbjct: 204 QEERLREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEER 263

Query: 710 --EQERQLAEQERR--REQERL-QAERELQEREKALRLQKEQLQRELE-----EKKKKEE 759
             EQE +L EQE R   ++ERL + E  L+E+E+ L  Q+E+L+ + E     E++ +E+
Sbjct: 264 LCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQ 323

Query: 760 QQRLAERQLQEEQEKKAKE 778
           ++RL E++    QE+  +E
Sbjct: 324 EERLCEQEKLPGQERLLEE 342


>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score =  110 bits (274), Expect = 8e-24
 Identities = 79/294 (26%), Positives = 165/294 (56%), Gaps = 20/294 (6%)

Query: 533 KERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERLR----KVLQARERVEQ 586
           K R++ E + R+EE    + +K+  +EDK  R EE   ++EE++R    K+ +  E++ +
Sbjct: 319 KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIRE 378

Query: 587 MKEEKKKQIEQKFAQ---IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 643
             E+ ++Q E+ + Q   I E+ EK +E+   +EK  ++   K  E+ E   +QEE+ R 
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE 438

Query: 644 LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQER 703
           L  + Q++EE+  +  +++K +EE+E++++  E  +  E++ QE+ E+  R+++  +QE 
Sbjct: 439 LEEMMQDQEEKLRE--VEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEE 496

Query: 704 R--EQER---REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKE 758
           +  EQE    R++E+   ++E+ +EQE     +E + RE+ +RL +++ + + +E + +E
Sbjct: 497 KIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQE 556

Query: 759 EQQRLAERQLQEEQEKKAKEAAGASKALNVT----VDVQSPACTSYQMTPQGHR 808
            ++RL +   + E    A   +G+ +   +T    V+++S    S Q     +R
Sbjct: 557 LEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYR 610



 Score =  107 bits (268), Expect = 4e-23
 Identities = 91/319 (28%), Positives = 174/319 (54%), Gaps = 33/319 (10%)

Query: 484 PASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRR 543
           P + ++     F H V+    +   T   R      + RNT    + KEK  +  E LR 
Sbjct: 171 PENSLLEETLHFDHAVRMGTYIEKLTKE-RDAPSLELYRNTITDEELKEKNAELQEKLRL 229

Query: 544 KEEAEQLRRQKVEEDKRRRLEEVKL--------KREERLRKVLQARERVEQMKEEK---- 591
            E +E+   Q   +D +R+LE  +L           +RL K LQ+     Q + E+    
Sbjct: 230 VE-SEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELW 288

Query: 592 ---KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL---R 645
               +Q E+K  + +EK ++ +EE++ E++ K +   +KM   E +  ++EE  R    +
Sbjct: 289 NLLNQQQEEKMWRQEEKIQE-QEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDK 347

Query: 646 WLQQEEEERRHQELLQKKKEE---EQERLRKAAEAKRLAEQREQERREQER-REQERREQ 701
             +QEE+ R  +E +++++E+   ++E++R+  E  ++ EQ E+  R++E+ REQE + Q
Sbjct: 348 MWRQEEKIREQEEKIREQEEKMWRQEEKIREQDE--KIQEQEEEMWRQEEKIREQEEKRQ 405

Query: 702 E---RREQERREQERQLAEQER---RREQERLQAERELQEREKALRLQKEQLQRELEEKK 755
           E   R+E++ REQ+ ++ EQE    R+E++  + E  +Q++E+ LR  +E++Q E E+ +
Sbjct: 406 EKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQ 465

Query: 756 KKEEQQRLAERQLQEEQEK 774
           ++EE+ +  E ++QE++EK
Sbjct: 466 EQEEKIQRQEEKIQEQEEK 484



 Score =  107 bits (266), Expect = 7e-23
 Identities = 66/256 (25%), Positives = 157/256 (61%), Gaps = 15/256 (5%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQM 587
           +++E+   + L+ +E+ E++ RQ+    E++++ R +E K+ R+E   K+ +  E++ + 
Sbjct: 308 EQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEE--KIREQEEKIREQ 365

Query: 588 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV-EARRKQEEEARRLRW 646
           +E+  +Q E+K  + DEK ++ +EE   +E+  ++   K+ E++    +K  E+  ++R 
Sbjct: 366 EEKMWRQ-EEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIR- 423

Query: 647 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ 706
            +QEEE  R +E +++ +E  Q++  K  E +   ++ E++ +EQE + Q + E+ + ++
Sbjct: 424 -EQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQE 482

Query: 707 ERREQERQLAEQERR---REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRL 763
           E+  ++ +L +QE +   +E++  + E ++ E+E+ ++ Q+E++QR+  E+K +E++ RL
Sbjct: 483 EKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQ--EEKMREQEVRL 540

Query: 764 -AERQLQEEQEKKAKE 778
             + +  +EQE + +E
Sbjct: 541 WQQEEKMQEQEVRLQE 556



 Score =  105 bits (263), Expect = 1e-22
 Identities = 70/265 (26%), Positives = 153/265 (57%), Gaps = 17/265 (6%)

Query: 526 LRMDPKEKERQRLENLRRKEE--AEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER 583
           L    +EK  ++ E ++ +EE   EQ  + + +E+K  R EE   ++EE++R+    +E 
Sbjct: 291 LNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIRE----QED 346

Query: 584 VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 643
               +EEK ++ E+K  + +EK  + +EE++ E+  K +   ++M   E + +++EE R+
Sbjct: 347 KMWRQEEKIREQEEKIREQEEKMWR-QEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQ 405

Query: 644 LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE--Q 701
            +  +QE++ R   E +++++EE   +  K  E + + + +E++ RE E + QE  E  Q
Sbjct: 406 EKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQ 465

Query: 702 ERREQERREQERQLAEQERRREQERL--------QAERELQEREKALRLQKEQLQRELEE 753
           E+ E+ +R++E+   ++E+   QE+L        + E ++  +E+ +  Q+E++Q + E+
Sbjct: 466 EQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEK 525

Query: 754 KKKKEEQQRLAERQLQEEQEKKAKE 778
            +++EE+ R  E +L +++EK  ++
Sbjct: 526 MQRQEEKMREQEVRLWQQEEKMQEQ 550



 Score =  103 bits (256), Expect = 1e-21
 Identities = 70/252 (27%), Positives = 151/252 (59%), Gaps = 12/252 (4%)

Query: 534 ERQRLENLRRKEEAEQLRRQ--KVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 591
           E   L NL  +++ E++ RQ  K++E + +  E+ +LK  E+  K+ +  E++ + +EEK
Sbjct: 283 EENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQ-ELKIREQEEKMWRQEEKMHE-QEEK 340

Query: 592 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA--RRLRWLQQ 649
            ++ E K  + +EK  + +EE++ E++ K     +K+ E + + +++EE   R+   +++
Sbjct: 341 IREQEDKMWRQEEKIRE-QEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399

Query: 650 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR-EQER 708
           +EE+R+ +   Q+KK  EQ+   K  E +    ++E++ RE E   Q++ E+ R  E++ 
Sbjct: 400 QEEKRQEKMWRQEKKMREQD--EKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKM 457

Query: 709 REQERQLAEQERR--REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAER 766
           +E+E ++ EQE +  R++E++Q + E   R++ L  Q+E++  + E+  ++EE+    E 
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEE 517

Query: 767 QLQEEQEKKAKE 778
           ++QE++EK  ++
Sbjct: 518 KMQEQEEKMQRQ 529



 Score = 97.1 bits (240), Expect = 7e-20
 Identities = 79/288 (27%), Positives = 156/288 (54%), Gaps = 15/288 (5%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKVEE--DKRRRLEEVKLKREERLRKVLQARERVEQMK 588
           +EK R++ E +R +EE    + +K+ E  +K +  EE   ++EE++R+  + R+     +
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411

Query: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648
           E+K ++ ++K  + +E+  + +EE++ E +   +   +K+ EVE + ++EEE      +Q
Sbjct: 412 EKKMREQDEKIREQEEEMWR-QEEKIRELEEMMQDQEEKLREVEEKMQEEEEK-----MQ 465

Query: 649 QEEEE-RRHQELLQKKKEE--EQERLRKAAEAKRLAEQREQERREQERR-EQERREQERR 704
           ++EE+ +R +E +Q+++E+   QE+L K  E  ++ EQ E+  R++E+  EQE + QE+ 
Sbjct: 466 EQEEKIQRQEEKIQEQEEKTWRQEKLLKQEE--KIWEQEEKMWRQEEKMWEQEEKMQEQE 523

Query: 705 EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEE-QQRL 763
           E+ +R++E+   ++ R  +QE    E+E++ +E   RL K   + EL     +E   QRL
Sbjct: 524 EKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRL 583

Query: 764 AERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPP 811
                  + E K++EA    +  +           +YQ    G  A P
Sbjct: 584 PTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYVAAYQQLASGKEALP 631



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 85/375 (22%), Positives = 186/375 (49%), Gaps = 45/375 (12%)

Query: 435 DQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRT 494
           D+ D   E   S + K S K+    L +++ +ED  +   +  +        K    +  
Sbjct: 85  DEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNE 144

Query: 495 FLHTVQRNQMLMTP------TSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAE 548
             +T ++  ++  P       +A +    S ++    L  D   +    +E L ++ +A 
Sbjct: 145 KNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEET--LHFDHAVRMGTYIEKLTKERDAP 202

Query: 549 QLR--RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKT 606
            L   R  + +++   L+E   + +E+LR V   +  ++   ++ K+++E+    + ++ 
Sbjct: 203 SLELYRNTITDEE---LKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQ 259

Query: 607 EKAKEERLAEE----KAKKKAAAKKMEEVEARRKQEEEA--RRLRWLQQEEEERRHQELL 660
            + + +RL +E     AK +A  ++ E      +Q+EE   R+   +Q++EE+   QEL 
Sbjct: 260 LQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELK 319

Query: 661 QKKKEEEQERLRKAAEAKRLAEQREQERREQE---RREQERREQE-----------RREQ 706
            +++EE+  R     + +++ EQ E+ R +++   R+E++ REQE           R+E+
Sbjct: 320 IREQEEKMWR-----QEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEE 374

Query: 707 ERREQERQLAEQERR--REQERLQAERELQE-----REKALRLQKEQLQRELEEKKKKEE 759
           + REQ+ ++ EQE    R++E+++ + E ++     +EK +R Q E+++ + EE  ++EE
Sbjct: 375 KIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEE 434

Query: 760 QQRLAERQLQEEQEK 774
           + R  E  +Q+++EK
Sbjct: 435 KIRELEEMMQDQEEK 449



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 65/257 (25%), Positives = 141/257 (54%), Gaps = 25/257 (9%)

Query: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK 588
           + +E+  ++ E +R +EE  Q +  + E+  R + E+++ + EE  R+  + RE  E M+
Sbjct: 385 EQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQ 444

Query: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648
           ++     E+K  +++EK ++ +EE++ E++ K +   +K++E     ++E+  R+ + L+
Sbjct: 445 DQ-----EEKLREVEEKMQE-EEEKMQEQEEKIQRQEEKIQE-----QEEKTWRQEKLLK 493

Query: 649 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQE----RREQERREQERR 704
           QEE+    +E + +++E+  E+  K  E +   +++E++ REQE    ++E++ +EQE R
Sbjct: 494 QEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVR 553

Query: 705 EQERREQERQLAEQE-------RRREQERLQAERELQEREKALRLQKEQ-LQRELEEKKK 756
            QE  E+  +L ++        R    +RL     + + E  L+ Q+ Q LQ++ +  + 
Sbjct: 554 LQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVE--LKSQEAQSLQQQQDHYRG 611

Query: 757 KEEQQRLAERQLQEEQE 773
             +Q   A +QL   +E
Sbjct: 612 HLQQYVAAYQQLASGKE 628



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 58/257 (22%), Positives = 111/257 (43%), Gaps = 21/257 (8%)

Query: 556 EEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEK----TEKAKE 611
           +ED        KL+++ ++R     + R + + +EK  Q+ +  A ++ +    T++  E
Sbjct: 27  DEDSDLDFHINKLEQQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTKRWDE 86

Query: 612 ERLAEEKAKKKAAAKKMEEVEARRKQE---EEARRLRWLQQEEEERRHQELLQKKKEEEQ 668
           +   EE    K   + ++ V      +   E+A      +  +E +   +  Q+K  E+ 
Sbjct: 87  DDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNEKN 146

Query: 669 ERLRKAAEAK----RLAEQREQERREQERREQ----ERREQERREQERREQERQLAEQER 720
              RK    K    RL E   Q+R E    E+    +   +     E+  +ER     E 
Sbjct: 147 YTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLEL 206

Query: 721 RR----EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEE--QQRLAERQLQEEQEK 774
            R    ++E  +   ELQE+ + +  +K ++Q  +++ K+K E  Q  L ++QLQ E ++
Sbjct: 207 YRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADR 266

Query: 775 KAKEAAGASKALNVTVD 791
             KE    S  L   V+
Sbjct: 267 LGKELQSVSAKLQAQVE 283



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 72/370 (19%), Positives = 155/370 (41%), Gaps = 29/370 (7%)

Query: 338 RLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNG 397
           RL K+     A     +  + L  LLN +  +K+  ++++  E+ E +   E ++ E   
Sbjct: 266 RLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQE- 324

Query: 398 NNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRK----RSY 453
              W   +          +      E     Q+E   +Q +  RE  +   R+    R  
Sbjct: 325 EKMWRQEE-----KMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQ 379

Query: 454 KQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRP----LRTFLHTVQRNQMLMTPT 509
            + + E +EE   ++E+++    K         K +R     +R     + R +  +   
Sbjct: 380 DEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIREL 439

Query: 510 SAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKV--------EEDKRR 561
                  +  ++       + +EK +++ E ++R+EE  Q + +K         +E+K  
Sbjct: 440 EEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIW 499

Query: 562 RLEEVKLKREERL---RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEK 618
             EE   ++EE++    + +Q +E   Q +EEK ++ E +  Q +EK ++ +E RL E +
Sbjct: 500 EQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQE-QEVRLQELE 558

Query: 619 AKKKAAAKKMEEV--EARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK-AA 675
            +     +K E +    R    +    L  + Q E + +  + LQ++++  +  L++  A
Sbjct: 559 ERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYVA 618

Query: 676 EAKRLAEQRE 685
             ++LA  +E
Sbjct: 619 AYQQLASGKE 628


>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score =  110 bits (274), Expect = 8e-24
 Identities = 79/294 (26%), Positives = 165/294 (56%), Gaps = 20/294 (6%)

Query: 533 KERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERLR----KVLQARERVEQ 586
           K R++ E + R+EE    + +K+  +EDK  R EE   ++EE++R    K+ +  E++ +
Sbjct: 319 KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIRE 378

Query: 587 MKEEKKKQIEQKFAQ---IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 643
             E+ ++Q E+ + Q   I E+ EK +E+   +EK  ++   K  E+ E   +QEE+ R 
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE 438

Query: 644 LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQER 703
           L  + Q++EE+  +  +++K +EE+E++++  E  +  E++ QE+ E+  R+++  +QE 
Sbjct: 439 LEEMMQDQEEKLRE--VEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEE 496

Query: 704 R--EQER---REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKE 758
           +  EQE    R++E+   ++E+ +EQE     +E + RE+ +RL +++ + + +E + +E
Sbjct: 497 KIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQE 556

Query: 759 EQQRLAERQLQEEQEKKAKEAAGASKALNVT----VDVQSPACTSYQMTPQGHR 808
            ++RL +   + E    A   +G+ +   +T    V+++S    S Q     +R
Sbjct: 557 LEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYR 610



 Score =  109 bits (272), Expect = 1e-23
 Identities = 91/319 (28%), Positives = 175/319 (54%), Gaps = 33/319 (10%)

Query: 484 PASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRR 543
           P + ++     F H V+    +   T   R  +   + RNT    + KEK  +  E LR 
Sbjct: 171 PENSLLEETLHFDHAVRMGTYIEKLTKE-RDALSLELYRNTITDEELKEKNAELQEKLRL 229

Query: 544 KEEAEQLRRQKVEEDKRRRLEEVKL--------KREERLRKVLQARERVEQMKEEK---- 591
            E +E+   Q   +D +R+LE  +L           +RL K LQ+     Q + E+    
Sbjct: 230 VE-SEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELW 288

Query: 592 ---KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL---R 645
               +Q E+K  + +EK ++ +EE++ E++ K +   +KM   E +  ++EE  R    +
Sbjct: 289 NLLNQQQEEKMWRQEEKIQE-QEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDK 347

Query: 646 WLQQEEEERRHQELLQKKKEE---EQERLRKAAEAKRLAEQREQERREQER-REQERREQ 701
             +QEE+ R  +E +++++E+   ++E++R+  E  ++ EQ E+  R++E+ REQE + Q
Sbjct: 348 MWRQEEKIREQEEKIREQEEKMWRQEEKIREQDE--KIQEQEEEMWRQEEKIREQEEKRQ 405

Query: 702 E---RREQERREQERQLAEQER---RREQERLQAERELQEREKALRLQKEQLQRELEEKK 755
           E   R+E++ REQ+ ++ EQE    R+E++  + E  +Q++E+ LR  +E++Q E E+ +
Sbjct: 406 EKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQ 465

Query: 756 KKEEQQRLAERQLQEEQEK 774
           ++EE+ +  E ++QE++EK
Sbjct: 466 EQEEKIQRQEEKIQEQEEK 484



 Score =  107 bits (266), Expect = 7e-23
 Identities = 66/256 (25%), Positives = 157/256 (61%), Gaps = 15/256 (5%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQM 587
           +++E+   + L+ +E+ E++ RQ+    E++++ R +E K+ R+E   K+ +  E++ + 
Sbjct: 308 EQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEE--KIREQEEKIREQ 365

Query: 588 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV-EARRKQEEEARRLRW 646
           +E+  +Q E+K  + DEK ++ +EE   +E+  ++   K+ E++    +K  E+  ++R 
Sbjct: 366 EEKMWRQ-EEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIR- 423

Query: 647 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ 706
            +QEEE  R +E +++ +E  Q++  K  E +   ++ E++ +EQE + Q + E+ + ++
Sbjct: 424 -EQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQE 482

Query: 707 ERREQERQLAEQERR---REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRL 763
           E+  ++ +L +QE +   +E++  + E ++ E+E+ ++ Q+E++QR+  E+K +E++ RL
Sbjct: 483 EKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQ--EEKMREQEVRL 540

Query: 764 -AERQLQEEQEKKAKE 778
             + +  +EQE + +E
Sbjct: 541 WQQEEKMQEQEVRLQE 556



 Score =  105 bits (263), Expect = 1e-22
 Identities = 70/265 (26%), Positives = 153/265 (57%), Gaps = 17/265 (6%)

Query: 526 LRMDPKEKERQRLENLRRKEE--AEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER 583
           L    +EK  ++ E ++ +EE   EQ  + + +E+K  R EE   ++EE++R+    +E 
Sbjct: 291 LNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIRE----QED 346

Query: 584 VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 643
               +EEK ++ E+K  + +EK  + +EE++ E+  K +   ++M   E + +++EE R+
Sbjct: 347 KMWRQEEKIREQEEKIREQEEKMWR-QEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQ 405

Query: 644 LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE--Q 701
            +  +QE++ R   E +++++EE   +  K  E + + + +E++ RE E + QE  E  Q
Sbjct: 406 EKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQ 465

Query: 702 ERREQERREQERQLAEQERRREQERL--------QAERELQEREKALRLQKEQLQRELEE 753
           E+ E+ +R++E+   ++E+   QE+L        + E ++  +E+ +  Q+E++Q + E+
Sbjct: 466 EQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEK 525

Query: 754 KKKKEEQQRLAERQLQEEQEKKAKE 778
            +++EE+ R  E +L +++EK  ++
Sbjct: 526 MQRQEEKMREQEVRLWQQEEKMQEQ 550



 Score =  103 bits (256), Expect = 1e-21
 Identities = 70/252 (27%), Positives = 151/252 (59%), Gaps = 12/252 (4%)

Query: 534 ERQRLENLRRKEEAEQLRRQ--KVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 591
           E   L NL  +++ E++ RQ  K++E + +  E+ +LK  E+  K+ +  E++ + +EEK
Sbjct: 283 EENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQ-ELKIREQEEKMWRQEEKMHE-QEEK 340

Query: 592 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA--RRLRWLQQ 649
            ++ E K  + +EK  + +EE++ E++ K     +K+ E + + +++EE   R+   +++
Sbjct: 341 IREQEDKMWRQEEKIRE-QEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399

Query: 650 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR-EQER 708
           +EE+R+ +   Q+KK  EQ+   K  E +    ++E++ RE E   Q++ E+ R  E++ 
Sbjct: 400 QEEKRQEKMWRQEKKMREQD--EKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKM 457

Query: 709 REQERQLAEQERR--REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAER 766
           +E+E ++ EQE +  R++E++Q + E   R++ L  Q+E++  + E+  ++EE+    E 
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEE 517

Query: 767 QLQEEQEKKAKE 778
           ++QE++EK  ++
Sbjct: 518 KMQEQEEKMQRQ 529



 Score = 97.1 bits (240), Expect = 7e-20
 Identities = 79/288 (27%), Positives = 156/288 (54%), Gaps = 15/288 (5%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKVEE--DKRRRLEEVKLKREERLRKVLQARERVEQMK 588
           +EK R++ E +R +EE    + +K+ E  +K +  EE   ++EE++R+  + R+     +
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411

Query: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648
           E+K ++ ++K  + +E+  + +EE++ E +   +   +K+ EVE + ++EEE      +Q
Sbjct: 412 EKKMREQDEKIREQEEEMWR-QEEKIRELEEMMQDQEEKLREVEEKMQEEEEK-----MQ 465

Query: 649 QEEEE-RRHQELLQKKKEE--EQERLRKAAEAKRLAEQREQERREQERR-EQERREQERR 704
           ++EE+ +R +E +Q+++E+   QE+L K  E  ++ EQ E+  R++E+  EQE + QE+ 
Sbjct: 466 EQEEKIQRQEEKIQEQEEKTWRQEKLLKQEE--KIWEQEEKMWRQEEKMWEQEEKMQEQE 523

Query: 705 EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEE-QQRL 763
           E+ +R++E+   ++ R  +QE    E+E++ +E   RL K   + EL     +E   QRL
Sbjct: 524 EKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRL 583

Query: 764 AERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPP 811
                  + E K++EA    +  +           +YQ    G  A P
Sbjct: 584 PTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYVAAYQQLASGKEALP 631



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 85/375 (22%), Positives = 186/375 (49%), Gaps = 45/375 (12%)

Query: 435 DQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRT 494
           D+ D   E   S + K S K+    L +++ +ED  +   +  +        K    +  
Sbjct: 85  DEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNE 144

Query: 495 FLHTVQRNQMLMTP------TSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAE 548
             +T ++  ++  P       +A +    S ++    L  D   +    +E L ++ +A 
Sbjct: 145 KNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEET--LHFDHAVRMGTYIEKLTKERDAL 202

Query: 549 QLR--RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKT 606
            L   R  + +++   L+E   + +E+LR V   +  ++   ++ K+++E+    + ++ 
Sbjct: 203 SLELYRNTITDEE---LKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQ 259

Query: 607 EKAKEERLAEE----KAKKKAAAKKMEEVEARRKQEEEA--RRLRWLQQEEEERRHQELL 660
            + + +RL +E     AK +A  ++ E      +Q+EE   R+   +Q++EE+   QEL 
Sbjct: 260 LQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELK 319

Query: 661 QKKKEEEQERLRKAAEAKRLAEQREQERREQE---RREQERREQE-----------RREQ 706
            +++EE+  R     + +++ EQ E+ R +++   R+E++ REQE           R+E+
Sbjct: 320 IREQEEKMWR-----QEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEE 374

Query: 707 ERREQERQLAEQERR--REQERLQAERELQE-----REKALRLQKEQLQRELEEKKKKEE 759
           + REQ+ ++ EQE    R++E+++ + E ++     +EK +R Q E+++ + EE  ++EE
Sbjct: 375 KIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEE 434

Query: 760 QQRLAERQLQEEQEK 774
           + R  E  +Q+++EK
Sbjct: 435 KIRELEEMMQDQEEK 449



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 65/257 (25%), Positives = 141/257 (54%), Gaps = 25/257 (9%)

Query: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK 588
           + +E+  ++ E +R +EE  Q +  + E+  R + E+++ + EE  R+  + RE  E M+
Sbjct: 385 EQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQ 444

Query: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648
           ++     E+K  +++EK ++ +EE++ E++ K +   +K++E     ++E+  R+ + L+
Sbjct: 445 DQ-----EEKLREVEEKMQE-EEEKMQEQEEKIQRQEEKIQE-----QEEKTWRQEKLLK 493

Query: 649 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQE----RREQERREQERR 704
           QEE+    +E + +++E+  E+  K  E +   +++E++ REQE    ++E++ +EQE R
Sbjct: 494 QEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVR 553

Query: 705 EQERREQERQLAEQE-------RRREQERLQAERELQEREKALRLQKEQ-LQRELEEKKK 756
            QE  E+  +L ++        R    +RL     + + E  L+ Q+ Q LQ++ +  + 
Sbjct: 554 LQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVE--LKSQEAQSLQQQQDHYRG 611

Query: 757 KEEQQRLAERQLQEEQE 773
             +Q   A +QL   +E
Sbjct: 612 HLQQYVAAYQQLASGKE 628



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 58/257 (22%), Positives = 111/257 (43%), Gaps = 21/257 (8%)

Query: 556 EEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEK----TEKAKE 611
           +ED        KL+++ ++R     + R + + +EK  Q+ +  A ++ +    T++  E
Sbjct: 27  DEDSDLDFHINKLEQQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTKRWDE 86

Query: 612 ERLAEEKAKKKAAAKKMEEVEARRKQE---EEARRLRWLQQEEEERRHQELLQKKKEEEQ 668
           +   EE    K   + ++ V      +   E+A      +  +E +   +  Q+K  E+ 
Sbjct: 87  DDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNEKN 146

Query: 669 ERLRKAAEAK----RLAEQREQERREQERREQ----ERREQERREQERREQERQLAEQER 720
              RK    K    RL E   Q+R E    E+    +   +     E+  +ER     E 
Sbjct: 147 YTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSLEL 206

Query: 721 RR----EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEE--QQRLAERQLQEEQEK 774
            R    ++E  +   ELQE+ + +  +K ++Q  +++ K+K E  Q  L ++QLQ E ++
Sbjct: 207 YRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADR 266

Query: 775 KAKEAAGASKALNVTVD 791
             KE    S  L   V+
Sbjct: 267 LGKELQSVSAKLQAQVE 283



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 72/370 (19%), Positives = 155/370 (41%), Gaps = 29/370 (7%)

Query: 338 RLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNG 397
           RL K+     A     +  + L  LLN +  +K+  ++++  E+ E +   E ++ E   
Sbjct: 266 RLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQE- 324

Query: 398 NNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRK----RSY 453
              W   +          +      E     Q+E   +Q +  RE  +   R+    R  
Sbjct: 325 EKMWRQEE-----KMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQ 379

Query: 454 KQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRP----LRTFLHTVQRNQMLMTPT 509
            + + E +EE   ++E+++    K         K +R     +R     + R +  +   
Sbjct: 380 DEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIREL 439

Query: 510 SAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKV--------EEDKRR 561
                  +  ++       + +EK +++ E ++R+EE  Q + +K         +E+K  
Sbjct: 440 EEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIW 499

Query: 562 RLEEVKLKREERL---RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEK 618
             EE   ++EE++    + +Q +E   Q +EEK ++ E +  Q +EK ++ +E RL E +
Sbjct: 500 EQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQE-QEVRLQELE 558

Query: 619 AKKKAAAKKMEEV--EARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK-AA 675
            +     +K E +    R    +    L  + Q E + +  + LQ++++  +  L++  A
Sbjct: 559 ERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYVA 618

Query: 676 EAKRLAEQRE 685
             ++LA  +E
Sbjct: 619 AYQQLASGKE 628


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score =  107 bits (266), Expect = 7e-23
 Identities = 55/199 (27%), Positives = 127/199 (63%), Gaps = 6/199 (3%)

Query: 582 ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA 641
           ER ++ +E +K++ E++  +  E+ +K K++R   E+ K++   +K  E + + ++E+E 
Sbjct: 35  ERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKER 94

Query: 642 RRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ 701
           R+ +  +++ E ++     +KKK+E +ER R   E K+  E++ ++RR+++RR++ +RE+
Sbjct: 95  RKRKKEKKKRERKQRGRRERKKKKERKERER---ENKQRRERKRKKRRKKKRRKERKREK 151

Query: 702 ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 761
           ER ++ER+ ++R+  E+E++RE+ R + ++E + +E+  R ++ + +R    KKK+ ++ 
Sbjct: 152 ERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKER---RKKKERKKD 208

Query: 762 RLAERQLQEEQEKKAKEAA 780
           R  +RQ   +  +  +E+A
Sbjct: 209 RKTDRQTDSQVFRPLRESA 227



 Score =  102 bits (254), Expect = 2e-21
 Identities = 63/213 (29%), Positives = 128/213 (60%), Gaps = 19/213 (8%)

Query: 566 VKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAA 625
           VKL  E ++       +   Q + E+KK+  ++  +  E+ ++ K ER  +EK K+K   
Sbjct: 11  VKLNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRE 70

Query: 626 KKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE 685
           +  E  E +RK+ E+ R+    ++ E+ERR      K+K+E+++R RK          R 
Sbjct: 71  RGKER-ERKRKEREKQRK----ERREKERR------KRKKEKKKRERKQ-------RGRR 112

Query: 686 QERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKE 745
           + ++++ER+E+ER  ++RRE++R+++ ++   +ER+RE+ER + ER+ ++R+K  R +K 
Sbjct: 113 ERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKR 172

Query: 746 QLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
           +  R+ E KK++E ++R   ++ ++++ +K KE
Sbjct: 173 ERNRK-ERKKERERKERRERKKERKKERRKKKE 204



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 58/215 (26%), Positives = 131/215 (60%), Gaps = 14/215 (6%)

Query: 517 KSFIKRNTPLRMDP-----KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKRE 571
           ++ +K NT L+M       K   ++  E  + + E E+ +R++ +E KR R ++ K KR+
Sbjct: 8   RAAVKLNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRK 67

Query: 572 ERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV 631
           +R R   + R+R E+ K+ K+++ +++  +  EK ++ +++R   E+ KKK   ++  E 
Sbjct: 68  KRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKEREREN 127

Query: 632 EARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQ 691
           + RR+++ + RR        +++R +E  ++K+  ++ER RK  + +   ++RE+ R+E+
Sbjct: 128 KQRRERKRKKRR--------KKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKER 179

Query: 692 ERREQERREQERREQERREQERQLAEQERRREQER 726
            ++E+ER+E+  R++ER+++ R+  E+++ R+ +R
Sbjct: 180 -KKERERKERRERKKERKKERRKKKERKKDRKTDR 213



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 63/214 (29%), Positives = 123/214 (57%), Gaps = 17/214 (7%)

Query: 518 SFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLR-RQKVEEDKRRRLE-----EVKLKRE 571
           S I +    R   ++KER+  E  +R+ E E+ R R K E+ KR++ E     E K K  
Sbjct: 23  SHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKER 82

Query: 572 ERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV 631
           E+ RK  + +ER ++ KE+KK++ +Q+  + + K +K ++ER  E K +++   KK  + 
Sbjct: 83  EKQRKERREKERRKRKKEKKKRERKQR-GRRERKKKKERKERERENKQRRERKRKKRRKK 141

Query: 632 EARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQ 691
           + R++++ E  R +  ++ + ++R +E  +KK+E      R   E K+  E++E+  R++
Sbjct: 142 KRRKERKREKERGK--RERKRKKRKKEEREKKRE------RNRKERKKERERKERRERKK 193

Query: 692 ERREQERREQERREQERREQERQLAEQERRREQE 725
           ER+++ R+++ER++   R+ +RQ   Q  R  +E
Sbjct: 194 ERKKERRKKKERKKD--RKTDRQTDSQVFRPLRE 225



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 30/114 (26%), Positives = 65/114 (57%), Gaps = 1/114 (0%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
           + KER+R    RR+ + ++ R++K  ++++R  E  K +R+ + RK  +  ++ E+ ++E
Sbjct: 119 ERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKE 178

Query: 591 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 644
           +KK+ E+K  + + K E+ KE R  +E+ K +   ++ +    R  +E    R+
Sbjct: 179 RKKERERKERR-ERKKERKKERRKKKERKKDRKTDRQTDSQVFRPLRESAFNRV 231


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score =  103 bits (258), Expect = 6e-22
 Identities = 90/286 (31%), Positives = 144/286 (50%), Gaps = 29/286 (10%)

Query: 510 SAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLK 569
           S P   M++    N     + K + RQ    +   E   +  ++    D     +E K K
Sbjct: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEK 190

Query: 570 REERLRKVLQA---RERVEQMKEEKKKQIEQ-------KFAQIDEKTEKAKEERLAEEKA 619
            EE   K  +      +VE M EEK  + ++       K  QI  +  K +EER  E+ +
Sbjct: 191 EEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEER--EQGS 248

Query: 620 KKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKR 679
            + +  +KMEE +  R + E AR    L+ EE ER   E   + K+   ER R  AE K 
Sbjct: 249 DEISHHEKMEEEDKERAEAERAR----LEAEERERIKAE---QDKKIADERARIEAEEKA 301

Query: 680 LAEQREQ-ERREQER-REQERREQERREQERREQERQLAEQERRREQERLQAE--RELQE 735
            A++RE+ E  E+ER RE+E+R  E R++ + E++R   E++R +E+E+  AE  + ++E
Sbjct: 302 AAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKE 361

Query: 736 REKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEE----QEKKAK 777
            EK    ++++ + E EEK K EEQ+R   +QL+E+    QE K K
Sbjct: 362 EEKRAAEERQRARAEEEEKAKVEEQKR--NKQLEEKKHAMQETKIK 405



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 92/399 (23%), Positives = 189/399 (47%), Gaps = 41/399 (10%)

Query: 410 NSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDE-EQHLED 468
           NS P+ +   ++  T   G  EA   +    RE     RR++  ++A+    E +  + D
Sbjct: 72  NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE----RRQKRLQEALERQKEFDPTITD 127

Query: 469 EELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRM 528
             L  P  +  +         +  ++   + Q    +    +  +S  K+  +     + 
Sbjct: 128 ASLSLPSRRMQNDTAENETTEKEEKS--ESRQERYEIEETETVTKSYQKNDWRDAEENKK 185

Query: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKL-------------KREERLR 575
           + KEKE +  E  +R    E      VEE      EE  +             K+EE   
Sbjct: 186 EDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEERE 245

Query: 576 KVLQARERVEQMKEEKKKQIEQKFAQID----EKTEKAKEERLAEEKAKKKAAAKKMEEV 631
           +        E+M+EE K++ E + A+++    E+ +  +++++A+E+A+ +A  K   + 
Sbjct: 246 QGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQ- 304

Query: 632 EARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQ 691
           E  R++ EE  R+R     EEE+R  E  Q+ KEEE+   R A E +R+ E+ ++   E+
Sbjct: 305 ERERREAEERERMR-----EEEKRAAEERQRIKEEEK---RAAEERQRIKEEEKRAAEER 356

Query: 692 ER-REQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRE 750
           +R +E+E+R  E R++ R E+E +   +E++R ++  + +  +QE     +++ E+++++
Sbjct: 357 QRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQE----TKIKGEKVEQK 412

Query: 751 LEEK---KKKEEQQRLAERQLQEEQEKKAKEAAGASKAL 786
           +E K   +KK ++ +L    L+++ E+K  +     + L
Sbjct: 413 IEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKL 451



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 101/419 (24%), Positives = 190/419 (45%), Gaps = 36/419 (8%)

Query: 357 SYLERLLNVEVP-QKVGSEQKEPPEEAEP-VAAAEPEVPENNGNNSWPHNDTEIANSTPN 414
           ++LERL   E   QK   E  E  +E +P +  A   +P     N    N+T     T  
Sbjct: 95  AFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENET-----TEK 149

Query: 415 PKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPP 474
            + + S  E     + E  T            + +K  ++ A     E++  E+EE + P
Sbjct: 150 EEKSESRQERYEIEETETVT-----------KSYQKNDWRDAEENKKEDKEKEEEEEEKP 198

Query: 475 RSKTPSSPCPASKVVRPL-----RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMD 529
           +  +         V          T + +++  Q+            +   + +   +M+
Sbjct: 199 KRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKME 258

Query: 530 PKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKE 589
            ++KER   E  R + EAE+  R K E+DK+   E  +++ EE+     Q RER E  + 
Sbjct: 259 EEDKERAEAE--RARLEAEERERIKAEQDKKIADERARIEAEEKA--AAQERERREAEER 314

Query: 590 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ 649
           E+ ++ E+K A  + +  K +E+R AEE+ + K   K+  E   R K+EE+         
Sbjct: 315 ERMRE-EEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR------AA 367

Query: 650 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERR 709
           EE +R   E  +K K EEQ+R ++  E K   ++ + +  + E++ + +   E++ QE +
Sbjct: 368 EERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDK 427

Query: 710 EQERQLAEQERRREQERLQAERE-LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ 767
            Q   L +Q   +   ++QA+RE LQE +   + ++ + ++  ++K+ KEE +   +R+
Sbjct: 428 LQTAVLKKQGEEK-GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRK 485



 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 109/442 (24%), Positives = 194/442 (43%), Gaps = 40/442 (9%)

Query: 370 KVGSEQKEPPEEAEPVAAA--EPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSA 427
           K   ++KE  EE +P   +  E +V       +    +  +  S  N + ++  P+    
Sbjct: 184 KKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE 243

Query: 428 GQQEA-------KTDQADGPREPPQSARRKRSYKQAVSE------LDEEQHLEDEELQPP 474
            +Q +       K ++ D  R   + AR +   ++ +         DE   +E EE    
Sbjct: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA 303

Query: 475 RSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKE 534
           + +         ++    +      QR +      +  R  +K   KR    R   KE+E
Sbjct: 304 QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEE 363

Query: 535 RQRLENLRRKEEAEQLRRQKVEEDKR-RRLEEVKLKREERLRKVLQARERVEQMKEEKKK 593
           ++  E  R++  AE+  + KVEE KR ++LEE K   +E   K  +  +++E     +KK
Sbjct: 364 KRAAEE-RQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKK 422

Query: 594 QIEQKFA------QIDEKTEK--AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 645
             E K        Q +EK  K  AK E+L E+K   K    K E+++  ++ +EE +   
Sbjct: 423 AQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFM 482

Query: 646 WLQQEEEERRHQE---LLQKKKEEEQERLRKAAEAKRLAEQREQERREQ----ERREQER 698
             ++   E + Q    +  K K  E    R    A    + +E E   Q    +R E+ R
Sbjct: 483 DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS--VDTKEAEGAPQVEAGKRLEELR 540

Query: 699 REQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKE 758
           R +   E E  E+ +Q  +QE   E E L+ +RE  ER K L  ++++ ++E  ++K +E
Sbjct: 541 RRRGETESEEFEKLKQ-KQQEAALELEELKKKRE--ERRKVLEEEEQRRKQEEADRKLRE 597

Query: 759 EQQRLAERQLQEEQEKKAKEAA 780
           E+++   R+L+EE E++  EAA
Sbjct: 598 EEEK---RRLKEEIERRRAEAA 616



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 90/379 (23%), Positives = 164/379 (43%), Gaps = 31/379 (8%)

Query: 370 KVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPN----PKPAASSPETP 425
           ++   +K   E+ E   A    +            D +IA+         K AA   E  
Sbjct: 250 EISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERR 309

Query: 426 SAGQQEAKTDQADGPREPPQSARRKRSYKQAVSE---LDEEQHLEDEELQ--PPRSKTPS 480
            A ++E   ++     E  Q  R K   K+A  E   + EE+    EE Q      K  +
Sbjct: 310 EAEERERMREEEKRAAEERQ--RIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA 367

Query: 481 SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLR---MDPKEKERQR 537
                ++     +  +   +RN+ L     A +       K    +    ++ K+ +  +
Sbjct: 368 EERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDK 427

Query: 538 LENLRRKEEAE------QLRRQKVEEDKRR-RLEEVKLKREERLRKVLQARERVEQMKEE 590
           L+    K++ E      Q +R+K++EDK   + EE+K   +E+++K  + +E V+   + 
Sbjct: 428 LQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIK---DEKIKKDKEPKEEVKSFMDR 484

Query: 591 KKKQIEQKFAQIDEKTEKAK--EERLAEEKAKKKAAAKKME---EVEARRKQEEEARRLR 645
           KK   E K    +  T K K  E   +    +     K+ E   +VEA ++ EE  RR  
Sbjct: 485 KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRG 544

Query: 646 WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE 705
             + EE E+  Q+  Q++   E E L+K  E +R   + E++RR+QE  +++ RE+E + 
Sbjct: 545 ETESEEFEKLKQK--QQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKR 602

Query: 706 QERREQERQLAEQERRREQ 724
           + + E ER+ AE   +R++
Sbjct: 603 RLKEEIERRRAEAAEKRQK 621



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 74/293 (25%), Positives = 128/293 (43%), Gaps = 51/293 (17%)

Query: 531 KEKERQRLENLRRKEEAEQLRR------------------------QKVEEDKRRRLEEV 566
           + + R R E LR+K+E E L +                         +VE D      E 
Sbjct: 40  ERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLER 99

Query: 567 KLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK 626
             +REER +K LQ  E +E+ KE      +   +    + +    E    EK +K  + +
Sbjct: 100 LARREERRQKRLQ--EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQ 157

Query: 627 KMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQ 686
           +  E+E      +  ++  W   EE ++  +E    K+EEE+E+ ++ +  +   E   +
Sbjct: 158 ERYEIEETETVTKSYQKNDWRDAEENKKEDKE----KEEEEEEKPKRGSIGENQVEVMVE 213

Query: 687 ERREQERRE-------------QERREQERREQ---ERREQERQLAEQERRREQERLQAE 730
           E+  + + E             +E +++E REQ   E    E+   E + R E ER + E
Sbjct: 214 EKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLE 273

Query: 731 RELQEREKA---LRLQKEQLQRELEEKKKKEEQQR--LAERQLQEEQEKKAKE 778
            E +ER KA    ++  E+ + E EEK   +E++R    ER+   E+EK+A E
Sbjct: 274 AEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAE 326



 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 80/339 (23%), Positives = 160/339 (47%), Gaps = 97/339 (28%)

Query: 531 KEKERQRLENLRRKEEAEQLRRQKVEED-------KRRRLEEVKLKREERLRKVLQARER 583
           +E  RQ+ E +R   EAE++  Q+ ++D       +RRR  + +L++++    + Q  ++
Sbjct: 8   RELRRQKREEMRL--EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQ 65

Query: 584 VE-----QMKEEKKK------QIE--------QKFAQIDEKTEKAKEERLAEEK------ 618
           VE      + +E+ K      Q+E        ++ A+ +E+ +K  +E L  +K      
Sbjct: 66  VEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTI 125

Query: 619 --AKKKAAAKKME----EVEARRKQEE-EARRLR-----------------WLQQEEEER 654
             A     +++M+    E E   K+E+ E+R+ R                 W   EE ++
Sbjct: 126 TDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKK 185

Query: 655 RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE-------------QERREQ 701
             +E    K+EEE+E+ ++ +  +   E   +E+  + + E             +E +++
Sbjct: 186 EDKE----KEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQE 241

Query: 702 ERREQ---------ERREQERQLAEQERRR----EQERLQAERE---------LQEREKA 739
           E REQ         +  E++++ AE ER R    E+ER++AE++         ++  EKA
Sbjct: 242 EEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKA 301

Query: 740 LRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
              ++E+ + E  E+ ++EE++   ERQ  +E+EK+A E
Sbjct: 302 AAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAE 340



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 72/278 (25%), Positives = 122/278 (43%), Gaps = 49/278 (17%)

Query: 545 EEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK--KKQIEQKFAQI 602
           E   +LRRQK EE  R   E +  +R +   +   ARER  + ++E+  +KQ E+   Q+
Sbjct: 5   ERRRELRRQKREE-MRLEAERIAYQRNDDDEEEA-ARERRRRARQERLRQKQEEESLGQV 62

Query: 603 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 662
            ++ E   +  + +E+AK      ++E        ++EA  L  L + EE R  Q+ LQ+
Sbjct: 63  TDQVEVNAQNSVPDEEAKTTTTNTQVEG-------DDEAAFLERLARREERR--QKRLQE 113

Query: 663 KKEEEQE---------------RLRKAAEAKRLAEQREQERREQERREQER--------- 698
             E ++E               R++         E+ E+    QER E E          
Sbjct: 114 ALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQ 173

Query: 699 ----REQERREQERREQERQLAEQERRREQERLQAE-------RELQEREKALRLQKEQL 747
               R+ E  ++E +E+E +  E+ +R      Q E        E QE    + L+  Q+
Sbjct: 174 KNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQI 233

Query: 748 QRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKA 785
             E E K+++E +Q   E    E+ E++ KE A A +A
Sbjct: 234 SSE-EPKQEEEREQGSDEISHHEKMEEEDKERAEAERA 270



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 38/152 (25%), Positives = 76/152 (50%), Gaps = 16/152 (10%)

Query: 651 EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERRE 710
           ++  R +EL ++K+EE +       EA+R+A QR  +  E+  RE+ RR ++ R ++++E
Sbjct: 2   DDFERRRELRRQKREEMR------LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQE 55

Query: 711 QERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 770
           +E       +  +Q  + A+  + + E        Q++ + E        +RLA R  +E
Sbjct: 56  EE----SLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE----AAFLERLARR--EE 105

Query: 771 EQEKKAKEAAGASKALNVTVDVQSPACTSYQM 802
            ++K+ +EA    K  + T+   S +  S +M
Sbjct: 106 RRQKRLQEALERQKEFDPTITDASLSLPSRRM 137



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 75/368 (20%), Positives = 144/368 (39%), Gaps = 46/368 (12%)

Query: 327 KQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVA 386
           K+E       R+ A+   EE A       +  LE   +     K+  E+ E   E + V 
Sbjct: 360 KEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVN 419

Query: 387 AAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQS 446
             E +  E+    +      E   +    K      + P+  ++E K ++    +EP + 
Sbjct: 420 --EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEE 477

Query: 447 AR----RKRSYKQAVSELDEE-----QHLEDEELQPP-RSKTPSSPCPASKVVRPLRTFL 496
            +    RK+ + +  S+  E      +H E+   +P  R+   +     +  V   +  L
Sbjct: 478 VKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR-L 536

Query: 497 HTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVE 556
             ++R +             +   ++     ++ +E +++R E  +  EE EQ R+Q+ E
Sbjct: 537 EELRRRR-----GETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE-E 590

Query: 557 EDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAE 616
            D+       KL+ EE  R++              K++IE++ A+  EK +K  E+ L++
Sbjct: 591 ADR-------KLREEEEKRRL--------------KEEIERRRAEAAEKRQKMPEDGLSD 629

Query: 617 EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE--ERRHQELLQKKKEEEQERLRKA 674
           +K   K    K   +    K EE A  L    Q+    +  HQ  +  K +   E+   A
Sbjct: 630 DKKPFKCFTPKGSSL----KIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSA 685

Query: 675 AEAKRLAE 682
            E  + A+
Sbjct: 686 IEGTKSAK 693


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  102 bits (253), Expect = 2e-21
 Identities = 100/387 (25%), Positives = 182/387 (47%), Gaps = 34/387 (8%)

Query: 418  AASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK 477
            A +  +  +  ++EAK  Q    R   +  RR+ +   AV    +++ +++E  Q  +S 
Sbjct: 1376 AEAHAQAKAQAEREAKELQQ---RMQEEVVRREEA---AVDAQQQKRSIQEELQQLRQSS 1429

Query: 478  TPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQR 537
                   A +     R+ L   +  +++     A              LR   +E E Q+
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489

Query: 538  LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERL--------RKVLQARERVEQMKE 589
             +    +EEAE+LRRQ  +E +R+R  EV+L    +         ++ LQA E +    E
Sbjct: 1490 RQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1546

Query: 590  EKKKQIEQ----KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 645
            E ++++ Q    +  Q+    E A+    AE ++K+ + A+K  ++E  R  +EE   + 
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE--RSLQEEHVAVA 1604

Query: 646  WLQQEEEERRHQELLQKKKEEEQER-----LRKAAEAKRL---AEQREQERREQERREQE 697
             L++E E R  Q+   ++  EE ER       KA EA RL   AE+  Q++   +   ++
Sbjct: 1605 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1664

Query: 698  RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
            ++E+  RE  RR +  + A ++R   ++ L+ +R+L E     RL  EQ    L  + ++
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1724

Query: 758  EEQQRLAERQLQEEQEKKAKEAAGASK 784
             EQQR   + L+EE  +  +EAA A++
Sbjct: 1725 GEQQR---QLLEEELARLQREAAAATQ 1748



 Score = 96.7 bits (239), Expect = 9e-20
 Identities = 150/595 (25%), Positives = 258/595 (43%), Gaps = 118/595 (19%)

Query: 296  SRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAK-QESVVRRASRRL----AKKTAEEPAAS 350
            +  + QS R S    ++   + L +++  VA+ +E   RRA ++     A++ AE     
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633

Query: 351  GRIICHSYLE-RLLNVEVPQKVG---SEQKEPPEEAEPVA-----AAEPEVPENNGNNSW 401
             ++  +  L  RL   EV Q+     +E ++  EEAE  A     A E  V +       
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693

Query: 402  PHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELD 461
                 ++A  T   + AA         +  A+T+Q +  R+  +     R  ++A +   
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELI----RLRAETEQGEQQRQLLEE-ELARLQREAAAATQ 1748

Query: 462  EEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK 521
            + Q LE  EL   R++        ++     R+   T ++++  +    A     +   +
Sbjct: 1749 KRQELE-AELAKVRAEMEVLLASKARAEEESRS---TSEKSKQRL---EAEAGRFRELAE 1801

Query: 522  RNTPLRMDPKEKERQRL----ENLRRKEEAEQLRRQKV----EEDKRRRLEEVKLKREE- 572
                LR   +E +RQR     +  R++ EAE++  +K+    E  + +   E+ LK +E 
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861

Query: 573  ---RLRKVLQ----ARERVEQMKEEKKKQIEQKFAQI----DEKTEKAK----------- 610
               RLR++ +     R R+E+   + K  IE++ AQ+    D + E+ K           
Sbjct: 1862 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1921

Query: 611  ---EERLAEEKAKKKAAAKKME--------------EVEARRKQEEEARRLRWLQQEEEE 653
               EE LA + + +KAAA K E               + ++ + E EA R R L  EEE 
Sbjct: 1922 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981

Query: 654  RRHQ--ELLQKK--KEEEQERLRKAA------------EAKRLAEQREQERREQ------ 691
            RR +  E +QK    EEE  R RKAA            EA+RL E+ EQE   Q      
Sbjct: 1982 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2041

Query: 692  -----------------ERREQERREQERREQERREQERQLAEQERR----REQERLQAE 730
                             +++EQE ++  ++EQ   +Q R  AE  RR     E+ R+QAE
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2101

Query: 731  RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKA 785
            RE  +  + +  + E+L++  EE+ +   Q + A  +L++E E++A   A A +A
Sbjct: 2102 REAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2155



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 75/243 (30%), Positives = 127/243 (52%), Gaps = 22/243 (9%)

Query: 539  ENLRRKEEAE---QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQI 595
            + LR KE+AE     +RQ   E++RRR E      EER++K L A E   + ++   +++
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREA-----EERVQKSLAAEEEAARQRKAALEEV 2011

Query: 596  EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 655
            E+  A+++E   +   ER  +E A++   A   +E   +R Q EE      +QQ+E+E  
Sbjct: 2012 ERLKAKVEEA--RRLRERAEQESARQLQLA---QEAAQKRLQAEEKAHAFAVQQKEQEL- 2065

Query: 656  HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ----ERREQERREQ 711
             Q+ LQ+++    +   +A  A+R AE+ E+ R + ER   + R Q    ER +Q   EQ
Sbjct: 2066 -QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2124

Query: 712  ERQLAEQERRREQERLQAERELQER---EKALRLQKEQLQRELEEKKKKEEQQRLAERQL 768
             +  A+ +   E+ R +AE+E   R   E+A   QK+    E+E+ KK  EQ    + Q+
Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184

Query: 769  QEE 771
            ++E
Sbjct: 2185 EQE 2187



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 87/327 (26%), Positives = 161/327 (49%), Gaps = 29/327 (8%)

Query: 531  KEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRL---EEVKLKREERLRKVLQARERVE 585
            + KE+  LE  R+++ A  E+ RR++ EE  ++ L   EE   +R+  L +V + + +VE
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019

Query: 586  QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE------ 639
            + +  +++  ++   Q+    E A++   AEEKA   A  +K +E++   +QE+      
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079

Query: 640  --EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 697
              EA   R   +E EE R    +Q ++E  Q R R+  EA+RL +Q  +E+ +   + Q 
Sbjct: 2080 RGEAEAARRAAEEAEEAR----VQAEREAAQSR-RQVEEAERL-KQSAEEQAQARAQAQA 2133

Query: 698  RREQERREQERREQERQLAEQERRREQERLQAERELQER--EKALRLQKEQLQRELEEKK 755
              E+ R+E E+    R  AEQ   R+++   AE E  ++  E+ LR QK Q+++EL   +
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTTLR 2192

Query: 756  KKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINP 815
             + E+    +  L EE ++   EA  A++  +    V+    +      +  +   +I  
Sbjct: 2193 LQLEETDHQKNLLDEELQRLKAEATEAARQRS---QVEEELFSVRVQMEELSKLKARIEA 2249

Query: 816  DNYGMDLNSDDST----DDEAHPRKPI 838
            +N  + L   D+T     +EA   K +
Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQV 2276



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 77/277 (27%), Positives = 135/277 (48%), Gaps = 18/277 (6%)

Query: 513  RSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 572
            R + ++  +       + KE +++  E + R+EEA        ++ KR   EE++  R+ 
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV----DAQQQKRSIQEELQQLRQS 1428

Query: 573  RLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVE 632
               ++ QA+ R  +  E  + +IE++   +  + E  + +R   E  + +A   + EE E
Sbjct: 1429 SEAEI-QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-GELQALRARAEEAE 1486

Query: 633  A--RRKQEEEARRLRWLQQEEEERRHQ---ELLQKKKEE-----EQERLRKAAEAKRLAE 682
            A  R+ Q EEA RLR   Q+E +R+ Q   EL  + K E     E++R  +A E  RL  
Sbjct: 1487 AQKRQAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1545

Query: 683  QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRL 742
            +  + R  Q   E+ R+ Q   E  +R  E +L  +     ++  Q ER LQE   A+  
Sbjct: 1546 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1605

Query: 743  QKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
             +E+ +R  +++ + E  +  AER+L E  + KA EA
Sbjct: 1606 LREEAERRAQQQAEAERAREEAEREL-ERWQLKANEA 1641



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 138/560 (24%), Positives = 235/560 (41%), Gaps = 117/560 (20%)

Query: 316  QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
            Q L Q+ S++ +       A+RR A++  E    + R    S   R    E  +   S +
Sbjct: 2067 QTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQS---RRQVEEAERLKQSAE 2122

Query: 376  KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTD 435
            ++    A+  AAAE    E          + E A      + A    +   A  ++ K  
Sbjct: 2123 EQAQARAQAQAAAEKLRKEA---------EQEAARRAQAEQAALRQKQAADAEMEKHKKF 2173

Query: 436  QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF 495
                 R+  Q  +   + +  + E D +++L DEELQ  +++   +    S+V   L + 
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233

Query: 496  LHTVQRNQMLMTPTSAPRSVMKSFIKRNTP-LRMDPKEKERQRLENLRR----KEEAEQL 550
               ++    L     A    +    K NT     +  EK +Q  E   R     +EA +L
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293

Query: 551  RRQKVEED--KRRRLEEVKLKREERLRKVLQAR------ERVEQMKE----------EKK 592
            R Q  EED  ++R L E  LK  E+++ V +A       E ++Q KE          E K
Sbjct: 2294 R-QLAEEDLAQQRALAEKMLK--EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2350

Query: 593  KQIEQKFAQIDE---KTEKAKEERLAEEKAKKKAAAKKMEEVE-ARRKQEEEARRLRWLQ 648
            +Q+ Q+ A+  +   +T +A+ +R  E  A+ +    ++ E+  A+ + EE+A+R R   
Sbjct: 2351 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2410

Query: 649  QEEEERRHQ---------------ELLQKKKEEEQERLRKA-AEAKRLAEQREQERR--- 689
            +E  E+ H+               E+ +++ + + ERLR+A AE +R  E+ +QE +   
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2470

Query: 690  ---------------------------------------EQERREQER-------REQER 703
                                                   EQE+ + E+       + Q+ 
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530

Query: 704  REQERREQERQLAEQERRR------EQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
            RE+++R+Q++   EQER+R      E  R Q E E   R K   LQ+ + QR  +E+   
Sbjct: 2531 REEQQRQQQQM--EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2588

Query: 758  EEQQRLAER-QLQEEQEKKA 776
            EE QRL E+ QL EEQ + A
Sbjct: 2589 EENQRLREQLQLLEEQHRAA 2608



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 98/403 (24%), Positives = 185/403 (45%), Gaps = 53/403 (13%)

Query: 445  QSARRKRSYKQAVSELDEEQHLED--------EELQPPRSKTPSSPCPASKVVRPLRTFL 496
            Q ARR++   QA+   D +   E         EE++    K       A + +  ++ + 
Sbjct: 1224 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1283

Query: 497  HTVQRNQMLMTPTSAP------RSVMKSFIKRNTPLRMDPKEKERQRL-------ENLRR 543
              +   +  + P ++P      +S  +S I+    LR    E             E LRR
Sbjct: 1284 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1343

Query: 544  KEEAEQLRRQKVEEDKRRRLE-EVKLKREERLRKV-LQARERVEQMKEEKKKQIEQKFAQ 601
             EE E+L  Q+  E++ R  E E  L+++ +L +   QA+ + E+  +E +++++++  +
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403

Query: 602  IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQ 661
             +E    A++++ + ++  ++       E++A+ +Q E A R R L+ EEE R     + 
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIR-----VV 1457

Query: 662  KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 721
            + + E  ER R  AE     E +    R +E   Q+R+ QE  E+ RR    Q+ ++ +R
Sbjct: 1458 RLQLEATERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRR----QVQDESQR 1509

Query: 722  REQ------ERLQAERE-LQEREKA------LRLQKEQLQREL---EEKKKKEEQQRLAE 765
            + Q       R++AE E  +E+++A      LRLQ E+ +R L   E ++ ++ Q  L  
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1569

Query: 766  RQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHR 808
             Q   E E ++K A+ A K   +   +Q       Q+  +  R
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER 1612



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 120/544 (22%), Positives = 218/544 (40%), Gaps = 79/544 (14%)

Query: 299  DSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSY 358
            +SQ  R + +  +S   +V A+  +   KQ ++      RL  + AE      R +  + 
Sbjct: 1506 ESQRKRQAEVELAS---RVKAEAEAAREKQRALQALEELRLQAEEAE------RRLRQAE 1556

Query: 359  LERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
            +ER   V+V  +      E   +++  + AE          S       +A      +  
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR 1613

Query: 419  ASSPETPSAGQQEA---------KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
            A         ++EA         K ++A   R   +   +++S  QA +E  +E   E E
Sbjct: 1614 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---EAE 1670

Query: 470  ELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMD 529
                 R K         + VR        +++ + L   T+  R   +  + R   LR +
Sbjct: 1671 REARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR---LRAE 1721

Query: 530  PKEKERQR------LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER 583
             ++ E+QR      L  L+R+  A   +RQ++E +    L +V+ + E  L    +A E 
Sbjct: 1722 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----LAKVRAEMEVLLASKARAEEE 1777

Query: 584  VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE--- 640
                 E+ K+++E +  +  E  E+A   R   E+AK++   +  EE  AR++ E E   
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--QLAEEDAARQRAEAERVL 1835

Query: 641  ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 700
            A +L  + +    +   E+  K+KE E ERLR+ AE +    +R +E+  Q + + E R 
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895

Query: 701  QERREQERREQERQLA------EQERRREQE-------------------------RLQA 729
             + R+    E ERQ         Q R+ E+E                         R  A
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955

Query: 730  ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVT 789
            E  L+ +E+A      Q Q   EE++++ E +   ++ L  E+E   +  A   +   + 
Sbjct: 1956 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2015

Query: 790  VDVQ 793
              V+
Sbjct: 2016 AKVE 2019



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 119/525 (22%), Positives = 224/525 (42%), Gaps = 92/525 (17%)

Query: 319  AQKYSLVAKQESVVRRASRRLAKK-TAEEPAASGRIICHSYLERLL-------------- 363
            A++  L A++E   R A  R+ K   AEE AA  R      +ERL               
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029

Query: 364  -----NVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
                  +++ Q+   ++ +  E+A   A  + E        +     + +       + A
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAA 2086

Query: 419  ASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKT 478
              + E     + +A+ + A   R+  ++ R K+S ++      + Q   ++  +    + 
Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146

Query: 479  PSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRL 538
                      +R  +     +++++     T   ++ ++  +   T LR+  +E + Q+ 
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL---TTLRLQLEETDHQKN 2203

Query: 539  ---ENLRR-KEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ 594
               E L+R K EA +  RQ+ + ++      V+++   +L+  ++A  R   +++   K 
Sbjct: 2204 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---KD 2260

Query: 595  IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEER 654
              Q+F Q  E+ EK K+  +AEE A+   AA             +EA RLR L +E+  +
Sbjct: 2261 NTQRFLQ--EEAEKMKQ--VAEEAARLSVAA-------------QEAARLRQLAEEDLAQ 2303

Query: 655  RH---QELLQKKKEEEQERLRKAAEAKRLAEQR----EQERREQERREQERRE------- 700
            +    +++L++K +  QE  R  AEA+ L +Q+    EQ RR QE +EQ  ++       
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363

Query: 701  -QERREQERREQERQLAEQER-------------RREQE----RLQAER--------ELQ 734
             Q   E ER+ Q    AE ER             R E++    R QAE         EL 
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423

Query: 735  EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
             +EK   +Q  ++QR+  +   +  ++ +AE  L+ E+EK  +EA
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKEKLQQEA 2466



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 70/275 (25%), Positives = 129/275 (46%), Gaps = 16/275 (5%)

Query: 532  EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKL--KREERLRKVLQARERVEQMKE 589
            E ERQR   +  + E  +LR  ++   + R  E+ +   K+ E + + L   E   Q K 
Sbjct: 2369 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2428

Query: 590  EKKKQIEQKFAQIDEKTEKAKEE--RLAEEKAKKKAAAK--KMEEVEARRKQEEEARRLR 645
               + +E +  Q D   E+ +E    L  EK K +  AK  +++  E +  Q+E+  +  
Sbjct: 2429 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2488

Query: 646  WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR- 704
               Q+        LLQ+++  EQE+ +     +    + +Q R EQ+R++Q+  ++ +R 
Sbjct: 2489 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2548

Query: 705  ---EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 761
                +E R ++ +  E  RR+++E  Q E++ +++E+ L    E+ QR  E+ +  EEQ 
Sbjct: 2549 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL---AEENQRLREQLQLLEEQH 2605

Query: 762  RLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPA 796
            R A   L   +E  A + A      N    +  PA
Sbjct: 2606 RAA---LAHSEEVTASQVAATKTLPNGRDALDGPA 2637



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 80/345 (23%), Positives = 153/345 (44%), Gaps = 46/345 (13%)

Query: 433  KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPL 492
            +T +A+  R+   SA  +R  K  V+E+   Q   +E+ Q  R +       A ++   L
Sbjct: 2366 RTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEEDAQRFRKQ-------AEEIGEKL 2417

Query: 493  -RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLR 551
             RT L T ++  ++ T                  ++    + + +RL     + E E+ +
Sbjct: 2418 HRTELATQEKVTLVQT----------------LEIQRQQSDHDAERLREAIAELEREKEK 2461

Query: 552  RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 611
             Q+  +  + + EE++  ++E+L   LQ  + ++Q    +K  + Q+   I++  EKAK 
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQL---LQETQALQQSFLSEKDSLLQRERFIEQ--EKAKL 2516

Query: 612  ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL 671
            E+L +++  K   A+++ E + R++Q+ E  R R +   EE RR Q   ++    +QE L
Sbjct: 2517 EQLFQDEVAK---AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2573

Query: 672  RKAAEAKRLAEQREQERREQERREQERREQERRE-QERREQERQLAEQERRREQERLQAE 730
                      +Q EQ+RR+QE    E  ++ R + Q   EQ R            ++ A 
Sbjct: 2574 ----------QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2623

Query: 731  RELQEREKAL--RLQKEQLQRELEEKKKKEEQQRLAERQLQEEQE 773
            + L     AL     + + +   +  ++K   QRL E  +   +E
Sbjct: 2624 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2668



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 61/278 (21%), Positives = 128/278 (46%), Gaps = 35/278 (12%)

Query: 541  LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR---KVLQARERVEQMKEEKKKQIEQ 597
            +R  + AE++ R   E+ K  +     L   E  +   K L+A+   +Q   +  +   +
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1154

Query: 598  KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA--------RRKQEEEARRLRWLQQ 649
               ++ E+ ++   ER  E +  ++  A+ +E  +A        +R+ E+  R+LR+ + 
Sbjct: 1155 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR- 1213

Query: 650  EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR--EQERREQERREQERREQE 707
            E  +     L   ++ +EQ +    A+++ + EQ  QE+   E+  R  E+ E+ +R  +
Sbjct: 1214 ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1273

Query: 708  R-----REQERQLAEQERRRE-------QERLQ--AERELQE-------REKALRLQKEQ 746
            +     ++ E QL   + + E       + ++Q  +E  +QE         +   L  + 
Sbjct: 1274 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333

Query: 747  LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 784
            ++   E  ++ EE++RLAE+Q  EE+E+ A+  A   K
Sbjct: 1334 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1371


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  102 bits (253), Expect = 2e-21
 Identities = 100/387 (25%), Positives = 182/387 (47%), Gaps = 34/387 (8%)

Query: 418  AASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK 477
            A +  +  +  ++EAK  Q    R   +  RR+ +   AV    +++ +++E  Q  +S 
Sbjct: 1380 AEAHAQAKAQAEREAKELQQ---RMQEEVVRREEA---AVDAQQQKRSIQEELQQLRQSS 1433

Query: 478  TPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQR 537
                   A +     R+ L   +  +++     A              LR   +E E Q+
Sbjct: 1434 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1493

Query: 538  LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERL--------RKVLQARERVEQMKE 589
             +    +EEAE+LRRQ  +E +R+R  EV+L    +         ++ LQA E +    E
Sbjct: 1494 RQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1550

Query: 590  EKKKQIEQ----KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 645
            E ++++ Q    +  Q+    E A+    AE ++K+ + A+K  ++E  R  +EE   + 
Sbjct: 1551 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE--RSLQEEHVAVA 1608

Query: 646  WLQQEEEERRHQELLQKKKEEEQER-----LRKAAEAKRL---AEQREQERREQERREQE 697
             L++E E R  Q+   ++  EE ER       KA EA RL   AE+  Q++   +   ++
Sbjct: 1609 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1668

Query: 698  RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
            ++E+  RE  RR +  + A ++R   ++ L+ +R+L E     RL  EQ    L  + ++
Sbjct: 1669 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1728

Query: 758  EEQQRLAERQLQEEQEKKAKEAAGASK 784
             EQQR   + L+EE  +  +EAA A++
Sbjct: 1729 GEQQR---QLLEEELARLQREAAAATQ 1752



 Score = 96.7 bits (239), Expect = 9e-20
 Identities = 150/595 (25%), Positives = 258/595 (43%), Gaps = 118/595 (19%)

Query: 296  SRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAK-QESVVRRASRRL----AKKTAEEPAAS 350
            +  + QS R S    ++   + L +++  VA+ +E   RRA ++     A++ AE     
Sbjct: 1578 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637

Query: 351  GRIICHSYLE-RLLNVEVPQKVG---SEQKEPPEEAEPVA-----AAEPEVPENNGNNSW 401
             ++  +  L  RL   EV Q+     +E ++  EEAE  A     A E  V +       
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1697

Query: 402  PHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELD 461
                 ++A  T   + AA         +  A+T+Q +  R+  +     R  ++A +   
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELI----RLRAETEQGEQQRQLLEE-ELARLQREAAAATQ 1752

Query: 462  EEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK 521
            + Q LE  EL   R++        ++     R+   T ++++  +    A     +   +
Sbjct: 1753 KRQELE-AELAKVRAEMEVLLASKARAEEESRS---TSEKSKQRL---EAEAGRFRELAE 1805

Query: 522  RNTPLRMDPKEKERQRL----ENLRRKEEAEQLRRQKV----EEDKRRRLEEVKLKREE- 572
                LR   +E +RQR     +  R++ EAE++  +K+    E  + +   E+ LK +E 
Sbjct: 1806 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1865

Query: 573  ---RLRKVLQ----ARERVEQMKEEKKKQIEQKFAQI----DEKTEKAK----------- 610
               RLR++ +     R R+E+   + K  IE++ AQ+    D + E+ K           
Sbjct: 1866 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1925

Query: 611  ---EERLAEEKAKKKAAAKKME--------------EVEARRKQEEEARRLRWLQQEEEE 653
               EE LA + + +KAAA K E               + ++ + E EA R R L  EEE 
Sbjct: 1926 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1985

Query: 654  RRHQ--ELLQKK--KEEEQERLRKAA------------EAKRLAEQREQERREQ------ 691
            RR +  E +QK    EEE  R RKAA            EA+RL E+ EQE   Q      
Sbjct: 1986 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2045

Query: 692  -----------------ERREQERREQERREQERREQERQLAEQERR----REQERLQAE 730
                             +++EQE ++  ++EQ   +Q R  AE  RR     E+ R+QAE
Sbjct: 2046 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2105

Query: 731  RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKA 785
            RE  +  + +  + E+L++  EE+ +   Q + A  +L++E E++A   A A +A
Sbjct: 2106 REAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2159



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 75/243 (30%), Positives = 127/243 (52%), Gaps = 22/243 (9%)

Query: 539  ENLRRKEEAE---QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQI 595
            + LR KE+AE     +RQ   E++RRR E      EER++K L A E   + ++   +++
Sbjct: 1961 DTLRSKEQAELEAARQRQLAAEEERRRREA-----EERVQKSLAAEEEAARQRKAALEEV 2015

Query: 596  EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 655
            E+  A+++E   +   ER  +E A++   A   +E   +R Q EE      +QQ+E+E  
Sbjct: 2016 ERLKAKVEEA--RRLRERAEQESARQLQLA---QEAAQKRLQAEEKAHAFAVQQKEQEL- 2069

Query: 656  HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ----ERREQERREQ 711
             Q+ LQ+++    +   +A  A+R AE+ E+ R + ER   + R Q    ER +Q   EQ
Sbjct: 2070 -QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2128

Query: 712  ERQLAEQERRREQERLQAERELQER---EKALRLQKEQLQRELEEKKKKEEQQRLAERQL 768
             +  A+ +   E+ R +AE+E   R   E+A   QK+    E+E+ KK  EQ    + Q+
Sbjct: 2129 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2188

Query: 769  QEE 771
            ++E
Sbjct: 2189 EQE 2191



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 87/327 (26%), Positives = 161/327 (49%), Gaps = 29/327 (8%)

Query: 531  KEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRL---EEVKLKREERLRKVLQARERVE 585
            + KE+  LE  R+++ A  E+ RR++ EE  ++ L   EE   +R+  L +V + + +VE
Sbjct: 1964 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2023

Query: 586  QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE------ 639
            + +  +++  ++   Q+    E A++   AEEKA   A  +K +E++   +QE+      
Sbjct: 2024 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2083

Query: 640  --EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 697
              EA   R   +E EE R    +Q ++E  Q R R+  EA+RL +Q  +E+ +   + Q 
Sbjct: 2084 RGEAEAARRAAEEAEEAR----VQAEREAAQSR-RQVEEAERL-KQSAEEQAQARAQAQA 2137

Query: 698  RREQERREQERREQERQLAEQERRREQERLQAERELQER--EKALRLQKEQLQRELEEKK 755
              E+ R+E E+    R  AEQ   R+++   AE E  ++  E+ LR QK Q+++EL   +
Sbjct: 2138 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTTLR 2196

Query: 756  KKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINP 815
             + E+    +  L EE ++   EA  A++  +    V+    +      +  +   +I  
Sbjct: 2197 LQLEETDHQKNLLDEELQRLKAEATEAARQRS---QVEEELFSVRVQMEELSKLKARIEA 2253

Query: 816  DNYGMDLNSDDST----DDEAHPRKPI 838
            +N  + L   D+T     +EA   K +
Sbjct: 2254 ENRALILRDKDNTQRFLQEEAEKMKQV 2280



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 77/277 (27%), Positives = 135/277 (48%), Gaps = 18/277 (6%)

Query: 513  RSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 572
            R + ++  +       + KE +++  E + R+EEA        ++ KR   EE++  R+ 
Sbjct: 1377 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV----DAQQQKRSIQEELQQLRQS 1432

Query: 573  RLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVE 632
               ++ QA+ R  +  E  + +IE++   +  + E  + +R   E  + +A   + EE E
Sbjct: 1433 SEAEI-QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-GELQALRARAEEAE 1490

Query: 633  A--RRKQEEEARRLRWLQQEEEERRHQ---ELLQKKKEE-----EQERLRKAAEAKRLAE 682
            A  R+ Q EEA RLR   Q+E +R+ Q   EL  + K E     E++R  +A E  RL  
Sbjct: 1491 AQKRQAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1549

Query: 683  QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRL 742
            +  + R  Q   E+ R+ Q   E  +R  E +L  +     ++  Q ER LQE   A+  
Sbjct: 1550 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1609

Query: 743  QKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
             +E+ +R  +++ + E  +  AER+L E  + KA EA
Sbjct: 1610 LREEAERRAQQQAEAERAREEAEREL-ERWQLKANEA 1645



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 138/560 (24%), Positives = 235/560 (41%), Gaps = 117/560 (20%)

Query: 316  QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
            Q L Q+ S++ +       A+RR A++  E    + R    S   R    E  +   S +
Sbjct: 2071 QTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQS---RRQVEEAERLKQSAE 2126

Query: 376  KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTD 435
            ++    A+  AAAE    E          + E A      + A    +   A  ++ K  
Sbjct: 2127 EQAQARAQAQAAAEKLRKEA---------EQEAARRAQAEQAALRQKQAADAEMEKHKKF 2177

Query: 436  QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF 495
                 R+  Q  +   + +  + E D +++L DEELQ  +++   +    S+V   L + 
Sbjct: 2178 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2237

Query: 496  LHTVQRNQMLMTPTSAPRSVMKSFIKRNTP-LRMDPKEKERQRLENLRR----KEEAEQL 550
               ++    L     A    +    K NT     +  EK +Q  E   R     +EA +L
Sbjct: 2238 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2297

Query: 551  RRQKVEED--KRRRLEEVKLKREERLRKVLQAR------ERVEQMKE----------EKK 592
            R Q  EED  ++R L E  LK  E+++ V +A       E ++Q KE          E K
Sbjct: 2298 R-QLAEEDLAQQRALAEKMLK--EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2354

Query: 593  KQIEQKFAQIDE---KTEKAKEERLAEEKAKKKAAAKKMEEVE-ARRKQEEEARRLRWLQ 648
            +Q+ Q+ A+  +   +T +A+ +R  E  A+ +    ++ E+  A+ + EE+A+R R   
Sbjct: 2355 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2414

Query: 649  QEEEERRHQ---------------ELLQKKKEEEQERLRKA-AEAKRLAEQREQERR--- 689
            +E  E+ H+               E+ +++ + + ERLR+A AE +R  E+ +QE +   
Sbjct: 2415 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2474

Query: 690  ---------------------------------------EQERREQER-------REQER 703
                                                   EQE+ + E+       + Q+ 
Sbjct: 2475 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2534

Query: 704  REQERREQERQLAEQERRR------EQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
            RE+++R+Q++   EQER+R      E  R Q E E   R K   LQ+ + QR  +E+   
Sbjct: 2535 REEQQRQQQQM--EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2592

Query: 758  EEQQRLAER-QLQEEQEKKA 776
            EE QRL E+ QL EEQ + A
Sbjct: 2593 EENQRLREQLQLLEEQHRAA 2612



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 98/403 (24%), Positives = 185/403 (45%), Gaps = 53/403 (13%)

Query: 445  QSARRKRSYKQAVSELDEEQHLED--------EELQPPRSKTPSSPCPASKVVRPLRTFL 496
            Q ARR++   QA+   D +   E         EE++    K       A + +  ++ + 
Sbjct: 1228 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1287

Query: 497  HTVQRNQMLMTPTSAP------RSVMKSFIKRNTPLRMDPKEKERQRL-------ENLRR 543
              +   +  + P ++P      +S  +S I+    LR    E             E LRR
Sbjct: 1288 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1347

Query: 544  KEEAEQLRRQKVEEDKRRRLE-EVKLKREERLRKV-LQARERVEQMKEEKKKQIEQKFAQ 601
             EE E+L  Q+  E++ R  E E  L+++ +L +   QA+ + E+  +E +++++++  +
Sbjct: 1348 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407

Query: 602  IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQ 661
             +E    A++++ + ++  ++       E++A+ +Q E A R R L+ EEE R     + 
Sbjct: 1408 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIR-----VV 1461

Query: 662  KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 721
            + + E  ER R  AE     E +    R +E   Q+R+ QE  E+ RR    Q+ ++ +R
Sbjct: 1462 RLQLEATERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRR----QVQDESQR 1513

Query: 722  REQ------ERLQAERE-LQEREKA------LRLQKEQLQREL---EEKKKKEEQQRLAE 765
            + Q       R++AE E  +E+++A      LRLQ E+ +R L   E ++ ++ Q  L  
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1573

Query: 766  RQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHR 808
             Q   E E ++K A+ A K   +   +Q       Q+  +  R
Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER 1616



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 120/544 (22%), Positives = 218/544 (40%), Gaps = 79/544 (14%)

Query: 299  DSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSY 358
            +SQ  R + +  +S   +V A+  +   KQ ++      RL  + AE      R +  + 
Sbjct: 1510 ESQRKRQAEVELAS---RVKAEAEAAREKQRALQALEELRLQAEEAE------RRLRQAE 1560

Query: 359  LERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
            +ER   V+V  +      E   +++  + AE          S       +A      +  
Sbjct: 1561 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR 1617

Query: 419  ASSPETPSAGQQEA---------KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
            A         ++EA         K ++A   R   +   +++S  QA +E  +E   E E
Sbjct: 1618 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---EAE 1674

Query: 470  ELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMD 529
                 R K         + VR        +++ + L   T+  R   +  + R   LR +
Sbjct: 1675 REARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR---LRAE 1725

Query: 530  PKEKERQR------LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER 583
             ++ E+QR      L  L+R+  A   +RQ++E +    L +V+ + E  L    +A E 
Sbjct: 1726 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----LAKVRAEMEVLLASKARAEEE 1781

Query: 584  VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE--- 640
                 E+ K+++E +  +  E  E+A   R   E+AK++   +  EE  AR++ E E   
Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--QLAEEDAARQRAEAERVL 1839

Query: 641  ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 700
            A +L  + +    +   E+  K+KE E ERLR+ AE +    +R +E+  Q + + E R 
Sbjct: 1840 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1899

Query: 701  QERREQERREQERQLA------EQERRREQE-------------------------RLQA 729
             + R+    E ERQ         Q R+ E+E                         R  A
Sbjct: 1900 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1959

Query: 730  ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVT 789
            E  L+ +E+A      Q Q   EE++++ E +   ++ L  E+E   +  A   +   + 
Sbjct: 1960 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2019

Query: 790  VDVQ 793
              V+
Sbjct: 2020 AKVE 2023



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 119/525 (22%), Positives = 224/525 (42%), Gaps = 92/525 (17%)

Query: 319  AQKYSLVAKQESVVRRASRRLAKK-TAEEPAASGRIICHSYLERLL-------------- 363
            A++  L A++E   R A  R+ K   AEE AA  R      +ERL               
Sbjct: 1974 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2033

Query: 364  -----NVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
                  +++ Q+   ++ +  E+A   A  + E        +     + +       + A
Sbjct: 2034 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAA 2090

Query: 419  ASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKT 478
              + E     + +A+ + A   R+  ++ R K+S ++      + Q   ++  +    + 
Sbjct: 2091 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150

Query: 479  PSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRL 538
                      +R  +     +++++     T   ++ ++  +   T LR+  +E + Q+ 
Sbjct: 2151 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL---TTLRLQLEETDHQKN 2207

Query: 539  ---ENLRR-KEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ 594
               E L+R K EA +  RQ+ + ++      V+++   +L+  ++A  R   +++   K 
Sbjct: 2208 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---KD 2264

Query: 595  IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEER 654
              Q+F Q  E+ EK K+  +AEE A+   AA             +EA RLR L +E+  +
Sbjct: 2265 NTQRFLQ--EEAEKMKQ--VAEEAARLSVAA-------------QEAARLRQLAEEDLAQ 2307

Query: 655  RH---QELLQKKKEEEQERLRKAAEAKRLAEQR----EQERREQERREQERRE------- 700
            +    +++L++K +  QE  R  AEA+ L +Q+    EQ RR QE +EQ  ++       
Sbjct: 2308 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2367

Query: 701  -QERREQERREQERQLAEQER-------------RREQE----RLQAER--------ELQ 734
             Q   E ER+ Q    AE ER             R E++    R QAE         EL 
Sbjct: 2368 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2427

Query: 735  EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
             +EK   +Q  ++QR+  +   +  ++ +AE  L+ E+EK  +EA
Sbjct: 2428 TQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKEKLQQEA 2470



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 70/275 (25%), Positives = 129/275 (46%), Gaps = 16/275 (5%)

Query: 532  EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKL--KREERLRKVLQARERVEQMKE 589
            E ERQR   +  + E  +LR  ++   + R  E+ +   K+ E + + L   E   Q K 
Sbjct: 2373 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2432

Query: 590  EKKKQIEQKFAQIDEKTEKAKEE--RLAEEKAKKKAAAK--KMEEVEARRKQEEEARRLR 645
               + +E +  Q D   E+ +E    L  EK K +  AK  +++  E +  Q+E+  +  
Sbjct: 2433 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2492

Query: 646  WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR- 704
               Q+        LLQ+++  EQE+ +     +    + +Q R EQ+R++Q+  ++ +R 
Sbjct: 2493 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2552

Query: 705  ---EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 761
                +E R ++ +  E  RR+++E  Q E++ +++E+ L    E+ QR  E+ +  EEQ 
Sbjct: 2553 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL---AEENQRLREQLQLLEEQH 2609

Query: 762  RLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPA 796
            R A   L   +E  A + A      N    +  PA
Sbjct: 2610 RAA---LAHSEEVTASQVAATKTLPNGRDALDGPA 2641



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 80/345 (23%), Positives = 153/345 (44%), Gaps = 46/345 (13%)

Query: 433  KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPL 492
            +T +A+  R+   SA  +R  K  V+E+   Q   +E+ Q  R +       A ++   L
Sbjct: 2370 RTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEEDAQRFRKQ-------AEEIGEKL 2421

Query: 493  -RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLR 551
             RT L T ++  ++ T                  ++    + + +RL     + E E+ +
Sbjct: 2422 HRTELATQEKVTLVQT----------------LEIQRQQSDHDAERLREAIAELEREKEK 2465

Query: 552  RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 611
             Q+  +  + + EE++  ++E+L   LQ  + ++Q    +K  + Q+   I++  EKAK 
Sbjct: 2466 LQQEAKLLQLKSEEMQTVQQEQL---LQETQALQQSFLSEKDSLLQRERFIEQ--EKAKL 2520

Query: 612  ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL 671
            E+L +++  K   A+++ E + R++Q+ E  R R +   EE RR Q   ++    +QE L
Sbjct: 2521 EQLFQDEVAK---AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2577

Query: 672  RKAAEAKRLAEQREQERREQERREQERREQERRE-QERREQERQLAEQERRREQERLQAE 730
                      +Q EQ+RR+QE    E  ++ R + Q   EQ R            ++ A 
Sbjct: 2578 ----------QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2627

Query: 731  RELQEREKAL--RLQKEQLQRELEEKKKKEEQQRLAERQLQEEQE 773
            + L     AL     + + +   +  ++K   QRL E  +   +E
Sbjct: 2628 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2672



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 61/278 (21%), Positives = 128/278 (46%), Gaps = 35/278 (12%)

Query: 541  LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR---KVLQARERVEQMKEEKKKQIEQ 597
            +R  + AE++ R   E+ K  +     L   E  +   K L+A+   +Q   +  +   +
Sbjct: 1099 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1158

Query: 598  KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA--------RRKQEEEARRLRWLQQ 649
               ++ E+ ++   ER  E +  ++  A+ +E  +A        +R+ E+  R+LR+ + 
Sbjct: 1159 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR- 1217

Query: 650  EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR--EQERREQERREQERREQE 707
            E  +     L   ++ +EQ +    A+++ + EQ  QE+   E+  R  E+ E+ +R  +
Sbjct: 1218 ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1277

Query: 708  R-----REQERQLAEQERRRE-------QERLQ--AERELQE-------REKALRLQKEQ 746
            +     ++ E QL   + + E       + ++Q  +E  +QE         +   L  + 
Sbjct: 1278 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1337

Query: 747  LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 784
            ++   E  ++ EE++RLAE+Q  EE+E+ A+  A   K
Sbjct: 1338 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1375


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  102 bits (253), Expect = 2e-21
 Identities = 100/387 (25%), Positives = 182/387 (47%), Gaps = 34/387 (8%)

Query: 418  AASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK 477
            A +  +  +  ++EAK  Q    R   +  RR+ +   AV    +++ +++E  Q  +S 
Sbjct: 1376 AEAHAQAKAQAEREAKELQQ---RMQEEVVRREEA---AVDAQQQKRSIQEELQQLRQSS 1429

Query: 478  TPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQR 537
                   A +     R+ L   +  +++     A              LR   +E E Q+
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489

Query: 538  LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERL--------RKVLQARERVEQMKE 589
             +    +EEAE+LRRQ  +E +R+R  EV+L    +         ++ LQA E +    E
Sbjct: 1490 RQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1546

Query: 590  EKKKQIEQ----KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 645
            E ++++ Q    +  Q+    E A+    AE ++K+ + A+K  ++E  R  +EE   + 
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE--RSLQEEHVAVA 1604

Query: 646  WLQQEEEERRHQELLQKKKEEEQER-----LRKAAEAKRL---AEQREQERREQERREQE 697
             L++E E R  Q+   ++  EE ER       KA EA RL   AE+  Q++   +   ++
Sbjct: 1605 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1664

Query: 698  RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
            ++E+  RE  RR +  + A ++R   ++ L+ +R+L E     RL  EQ    L  + ++
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1724

Query: 758  EEQQRLAERQLQEEQEKKAKEAAGASK 784
             EQQR   + L+EE  +  +EAA A++
Sbjct: 1725 GEQQR---QLLEEELARLQREAAAATQ 1748



 Score = 96.7 bits (239), Expect = 9e-20
 Identities = 150/595 (25%), Positives = 258/595 (43%), Gaps = 118/595 (19%)

Query: 296  SRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAK-QESVVRRASRRL----AKKTAEEPAAS 350
            +  + QS R S    ++   + L +++  VA+ +E   RRA ++     A++ AE     
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633

Query: 351  GRIICHSYLE-RLLNVEVPQKVG---SEQKEPPEEAEPVA-----AAEPEVPENNGNNSW 401
             ++  +  L  RL   EV Q+     +E ++  EEAE  A     A E  V +       
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693

Query: 402  PHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELD 461
                 ++A  T   + AA         +  A+T+Q +  R+  +     R  ++A +   
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELI----RLRAETEQGEQQRQLLEE-ELARLQREAAAATQ 1748

Query: 462  EEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK 521
            + Q LE  EL   R++        ++     R+   T ++++  +    A     +   +
Sbjct: 1749 KRQELE-AELAKVRAEMEVLLASKARAEEESRS---TSEKSKQRL---EAEAGRFRELAE 1801

Query: 522  RNTPLRMDPKEKERQRL----ENLRRKEEAEQLRRQKV----EEDKRRRLEEVKLKREE- 572
                LR   +E +RQR     +  R++ EAE++  +K+    E  + +   E+ LK +E 
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861

Query: 573  ---RLRKVLQ----ARERVEQMKEEKKKQIEQKFAQI----DEKTEKAK----------- 610
               RLR++ +     R R+E+   + K  IE++ AQ+    D + E+ K           
Sbjct: 1862 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1921

Query: 611  ---EERLAEEKAKKKAAAKKME--------------EVEARRKQEEEARRLRWLQQEEEE 653
               EE LA + + +KAAA K E               + ++ + E EA R R L  EEE 
Sbjct: 1922 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981

Query: 654  RRHQ--ELLQKK--KEEEQERLRKAA------------EAKRLAEQREQERREQ------ 691
            RR +  E +QK    EEE  R RKAA            EA+RL E+ EQE   Q      
Sbjct: 1982 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2041

Query: 692  -----------------ERREQERREQERREQERREQERQLAEQERR----REQERLQAE 730
                             +++EQE ++  ++EQ   +Q R  AE  RR     E+ R+QAE
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2101

Query: 731  RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKA 785
            RE  +  + +  + E+L++  EE+ +   Q + A  +L++E E++A   A A +A
Sbjct: 2102 REAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2155



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 75/243 (30%), Positives = 127/243 (52%), Gaps = 22/243 (9%)

Query: 539  ENLRRKEEAE---QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQI 595
            + LR KE+AE     +RQ   E++RRR E      EER++K L A E   + ++   +++
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREA-----EERVQKSLAAEEEAARQRKAALEEV 2011

Query: 596  EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 655
            E+  A+++E   +   ER  +E A++   A   +E   +R Q EE      +QQ+E+E  
Sbjct: 2012 ERLKAKVEEA--RRLRERAEQESARQLQLA---QEAAQKRLQAEEKAHAFAVQQKEQEL- 2065

Query: 656  HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ----ERREQERREQ 711
             Q+ LQ+++    +   +A  A+R AE+ E+ R + ER   + R Q    ER +Q   EQ
Sbjct: 2066 -QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2124

Query: 712  ERQLAEQERRREQERLQAERELQER---EKALRLQKEQLQRELEEKKKKEEQQRLAERQL 768
             +  A+ +   E+ R +AE+E   R   E+A   QK+    E+E+ KK  EQ    + Q+
Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184

Query: 769  QEE 771
            ++E
Sbjct: 2185 EQE 2187



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 87/327 (26%), Positives = 161/327 (49%), Gaps = 29/327 (8%)

Query: 531  KEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRL---EEVKLKREERLRKVLQARERVE 585
            + KE+  LE  R+++ A  E+ RR++ EE  ++ L   EE   +R+  L +V + + +VE
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019

Query: 586  QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE------ 639
            + +  +++  ++   Q+    E A++   AEEKA   A  +K +E++   +QE+      
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079

Query: 640  --EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 697
              EA   R   +E EE R    +Q ++E  Q R R+  EA+RL +Q  +E+ +   + Q 
Sbjct: 2080 RGEAEAARRAAEEAEEAR----VQAEREAAQSR-RQVEEAERL-KQSAEEQAQARAQAQA 2133

Query: 698  RREQERREQERREQERQLAEQERRREQERLQAERELQER--EKALRLQKEQLQRELEEKK 755
              E+ R+E E+    R  AEQ   R+++   AE E  ++  E+ LR QK Q+++EL   +
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTTLR 2192

Query: 756  KKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINP 815
             + E+    +  L EE ++   EA  A++  +    V+    +      +  +   +I  
Sbjct: 2193 LQLEETDHQKNLLDEELQRLKAEATEAARQRS---QVEEELFSVRVQMEELSKLKARIEA 2249

Query: 816  DNYGMDLNSDDST----DDEAHPRKPI 838
            +N  + L   D+T     +EA   K +
Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQV 2276



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 77/277 (27%), Positives = 135/277 (48%), Gaps = 18/277 (6%)

Query: 513  RSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 572
            R + ++  +       + KE +++  E + R+EEA        ++ KR   EE++  R+ 
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV----DAQQQKRSIQEELQQLRQS 1428

Query: 573  RLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVE 632
               ++ QA+ R  +  E  + +IE++   +  + E  + +R   E  + +A   + EE E
Sbjct: 1429 SEAEI-QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-GELQALRARAEEAE 1486

Query: 633  A--RRKQEEEARRLRWLQQEEEERRHQ---ELLQKKKEE-----EQERLRKAAEAKRLAE 682
            A  R+ Q EEA RLR   Q+E +R+ Q   EL  + K E     E++R  +A E  RL  
Sbjct: 1487 AQKRQAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1545

Query: 683  QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRL 742
            +  + R  Q   E+ R+ Q   E  +R  E +L  +     ++  Q ER LQE   A+  
Sbjct: 1546 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1605

Query: 743  QKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
             +E+ +R  +++ + E  +  AER+L E  + KA EA
Sbjct: 1606 LREEAERRAQQQAEAERAREEAEREL-ERWQLKANEA 1641



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 138/560 (24%), Positives = 235/560 (41%), Gaps = 117/560 (20%)

Query: 316  QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
            Q L Q+ S++ +       A+RR A++  E    + R    S   R    E  +   S +
Sbjct: 2067 QTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQS---RRQVEEAERLKQSAE 2122

Query: 376  KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTD 435
            ++    A+  AAAE    E          + E A      + A    +   A  ++ K  
Sbjct: 2123 EQAQARAQAQAAAEKLRKEA---------EQEAARRAQAEQAALRQKQAADAEMEKHKKF 2173

Query: 436  QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF 495
                 R+  Q  +   + +  + E D +++L DEELQ  +++   +    S+V   L + 
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233

Query: 496  LHTVQRNQMLMTPTSAPRSVMKSFIKRNTP-LRMDPKEKERQRLENLRR----KEEAEQL 550
               ++    L     A    +    K NT     +  EK +Q  E   R     +EA +L
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293

Query: 551  RRQKVEED--KRRRLEEVKLKREERLRKVLQAR------ERVEQMKE----------EKK 592
            R Q  EED  ++R L E  LK  E+++ V +A       E ++Q KE          E K
Sbjct: 2294 R-QLAEEDLAQQRALAEKMLK--EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2350

Query: 593  KQIEQKFAQIDE---KTEKAKEERLAEEKAKKKAAAKKMEEVE-ARRKQEEEARRLRWLQ 648
            +Q+ Q+ A+  +   +T +A+ +R  E  A+ +    ++ E+  A+ + EE+A+R R   
Sbjct: 2351 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2410

Query: 649  QEEEERRHQ---------------ELLQKKKEEEQERLRKA-AEAKRLAEQREQERR--- 689
            +E  E+ H+               E+ +++ + + ERLR+A AE +R  E+ +QE +   
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2470

Query: 690  ---------------------------------------EQERREQER-------REQER 703
                                                   EQE+ + E+       + Q+ 
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530

Query: 704  REQERREQERQLAEQERRR------EQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
            RE+++R+Q++   EQER+R      E  R Q E E   R K   LQ+ + QR  +E+   
Sbjct: 2531 REEQQRQQQQM--EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2588

Query: 758  EEQQRLAER-QLQEEQEKKA 776
            EE QRL E+ QL EEQ + A
Sbjct: 2589 EENQRLREQLQLLEEQHRAA 2608



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 98/403 (24%), Positives = 185/403 (45%), Gaps = 53/403 (13%)

Query: 445  QSARRKRSYKQAVSELDEEQHLED--------EELQPPRSKTPSSPCPASKVVRPLRTFL 496
            Q ARR++   QA+   D +   E         EE++    K       A + +  ++ + 
Sbjct: 1224 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1283

Query: 497  HTVQRNQMLMTPTSAP------RSVMKSFIKRNTPLRMDPKEKERQRL-------ENLRR 543
              +   +  + P ++P      +S  +S I+    LR    E             E LRR
Sbjct: 1284 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1343

Query: 544  KEEAEQLRRQKVEEDKRRRLE-EVKLKREERLRKV-LQARERVEQMKEEKKKQIEQKFAQ 601
             EE E+L  Q+  E++ R  E E  L+++ +L +   QA+ + E+  +E +++++++  +
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403

Query: 602  IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQ 661
             +E    A++++ + ++  ++       E++A+ +Q E A R R L+ EEE R     + 
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIR-----VV 1457

Query: 662  KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 721
            + + E  ER R  AE     E +    R +E   Q+R+ QE  E+ RR    Q+ ++ +R
Sbjct: 1458 RLQLEATERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRR----QVQDESQR 1509

Query: 722  REQ------ERLQAERE-LQEREKA------LRLQKEQLQREL---EEKKKKEEQQRLAE 765
            + Q       R++AE E  +E+++A      LRLQ E+ +R L   E ++ ++ Q  L  
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1569

Query: 766  RQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHR 808
             Q   E E ++K A+ A K   +   +Q       Q+  +  R
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER 1612



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 120/544 (22%), Positives = 218/544 (40%), Gaps = 79/544 (14%)

Query: 299  DSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSY 358
            +SQ  R + +  +S   +V A+  +   KQ ++      RL  + AE      R +  + 
Sbjct: 1506 ESQRKRQAEVELAS---RVKAEAEAAREKQRALQALEELRLQAEEAE------RRLRQAE 1556

Query: 359  LERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
            +ER   V+V  +      E   +++  + AE          S       +A      +  
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR 1613

Query: 419  ASSPETPSAGQQEA---------KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
            A         ++EA         K ++A   R   +   +++S  QA +E  +E   E E
Sbjct: 1614 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---EAE 1670

Query: 470  ELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMD 529
                 R K         + VR        +++ + L   T+  R   +  + R   LR +
Sbjct: 1671 REARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR---LRAE 1721

Query: 530  PKEKERQR------LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER 583
             ++ E+QR      L  L+R+  A   +RQ++E +    L +V+ + E  L    +A E 
Sbjct: 1722 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----LAKVRAEMEVLLASKARAEEE 1777

Query: 584  VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE--- 640
                 E+ K+++E +  +  E  E+A   R   E+AK++   +  EE  AR++ E E   
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--QLAEEDAARQRAEAERVL 1835

Query: 641  ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 700
            A +L  + +    +   E+  K+KE E ERLR+ AE +    +R +E+  Q + + E R 
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895

Query: 701  QERREQERREQERQLA------EQERRREQE-------------------------RLQA 729
             + R+    E ERQ         Q R+ E+E                         R  A
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955

Query: 730  ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVT 789
            E  L+ +E+A      Q Q   EE++++ E +   ++ L  E+E   +  A   +   + 
Sbjct: 1956 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2015

Query: 790  VDVQ 793
              V+
Sbjct: 2016 AKVE 2019



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 119/525 (22%), Positives = 224/525 (42%), Gaps = 92/525 (17%)

Query: 319  AQKYSLVAKQESVVRRASRRLAKK-TAEEPAASGRIICHSYLERLL-------------- 363
            A++  L A++E   R A  R+ K   AEE AA  R      +ERL               
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029

Query: 364  -----NVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
                  +++ Q+   ++ +  E+A   A  + E        +     + +       + A
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAA 2086

Query: 419  ASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKT 478
              + E     + +A+ + A   R+  ++ R K+S ++      + Q   ++  +    + 
Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146

Query: 479  PSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRL 538
                      +R  +     +++++     T   ++ ++  +   T LR+  +E + Q+ 
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL---TTLRLQLEETDHQKN 2203

Query: 539  ---ENLRR-KEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ 594
               E L+R K EA +  RQ+ + ++      V+++   +L+  ++A  R   +++   K 
Sbjct: 2204 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---KD 2260

Query: 595  IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEER 654
              Q+F Q  E+ EK K+  +AEE A+   AA             +EA RLR L +E+  +
Sbjct: 2261 NTQRFLQ--EEAEKMKQ--VAEEAARLSVAA-------------QEAARLRQLAEEDLAQ 2303

Query: 655  RH---QELLQKKKEEEQERLRKAAEAKRLAEQR----EQERREQERREQERRE------- 700
            +    +++L++K +  QE  R  AEA+ L +Q+    EQ RR QE +EQ  ++       
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363

Query: 701  -QERREQERREQERQLAEQER-------------RREQE----RLQAER--------ELQ 734
             Q   E ER+ Q    AE ER             R E++    R QAE         EL 
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423

Query: 735  EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
             +EK   +Q  ++QR+  +   +  ++ +AE  L+ E+EK  +EA
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKEKLQQEA 2466



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 70/275 (25%), Positives = 129/275 (46%), Gaps = 16/275 (5%)

Query: 532  EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKL--KREERLRKVLQARERVEQMKE 589
            E ERQR   +  + E  +LR  ++   + R  E+ +   K+ E + + L   E   Q K 
Sbjct: 2369 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2428

Query: 590  EKKKQIEQKFAQIDEKTEKAKEE--RLAEEKAKKKAAAK--KMEEVEARRKQEEEARRLR 645
               + +E +  Q D   E+ +E    L  EK K +  AK  +++  E +  Q+E+  +  
Sbjct: 2429 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2488

Query: 646  WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR- 704
               Q+        LLQ+++  EQE+ +     +    + +Q R EQ+R++Q+  ++ +R 
Sbjct: 2489 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2548

Query: 705  ---EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 761
                +E R ++ +  E  RR+++E  Q E++ +++E+ L    E+ QR  E+ +  EEQ 
Sbjct: 2549 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL---AEENQRLREQLQLLEEQH 2605

Query: 762  RLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPA 796
            R A   L   +E  A + A      N    +  PA
Sbjct: 2606 RAA---LAHSEEVTASQVAATKTLPNGRDALDGPA 2637



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 80/345 (23%), Positives = 153/345 (44%), Gaps = 46/345 (13%)

Query: 433  KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPL 492
            +T +A+  R+   SA  +R  K  V+E+   Q   +E+ Q  R +       A ++   L
Sbjct: 2366 RTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEEDAQRFRKQ-------AEEIGEKL 2417

Query: 493  -RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLR 551
             RT L T ++  ++ T                  ++    + + +RL     + E E+ +
Sbjct: 2418 HRTELATQEKVTLVQT----------------LEIQRQQSDHDAERLREAIAELEREKEK 2461

Query: 552  RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 611
             Q+  +  + + EE++  ++E+L   LQ  + ++Q    +K  + Q+   I++  EKAK 
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQL---LQETQALQQSFLSEKDSLLQRERFIEQ--EKAKL 2516

Query: 612  ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL 671
            E+L +++  K   A+++ E + R++Q+ E  R R +   EE RR Q   ++    +QE L
Sbjct: 2517 EQLFQDEVAK---AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2573

Query: 672  RKAAEAKRLAEQREQERREQERREQERREQERRE-QERREQERQLAEQERRREQERLQAE 730
                      +Q EQ+RR+QE    E  ++ R + Q   EQ R            ++ A 
Sbjct: 2574 ----------QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2623

Query: 731  RELQEREKAL--RLQKEQLQRELEEKKKKEEQQRLAERQLQEEQE 773
            + L     AL     + + +   +  ++K   QRL E  +   +E
Sbjct: 2624 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2668



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 61/278 (21%), Positives = 128/278 (46%), Gaps = 35/278 (12%)

Query: 541  LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR---KVLQARERVEQMKEEKKKQIEQ 597
            +R  + AE++ R   E+ K  +     L   E  +   K L+A+   +Q   +  +   +
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1154

Query: 598  KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA--------RRKQEEEARRLRWLQQ 649
               ++ E+ ++   ER  E +  ++  A+ +E  +A        +R+ E+  R+LR+ + 
Sbjct: 1155 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR- 1213

Query: 650  EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR--EQERREQERREQERREQE 707
            E  +     L   ++ +EQ +    A+++ + EQ  QE+   E+  R  E+ E+ +R  +
Sbjct: 1214 ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1273

Query: 708  R-----REQERQLAEQERRRE-------QERLQ--AERELQE-------REKALRLQKEQ 746
            +     ++ E QL   + + E       + ++Q  +E  +QE         +   L  + 
Sbjct: 1274 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333

Query: 747  LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 784
            ++   E  ++ EE++RLAE+Q  EE+E+ A+  A   K
Sbjct: 1334 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1371


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  102 bits (253), Expect = 2e-21
 Identities = 100/387 (25%), Positives = 182/387 (47%), Gaps = 34/387 (8%)

Query: 418  AASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK 477
            A +  +  +  ++EAK  Q    R   +  RR+ +   AV    +++ +++E  Q  +S 
Sbjct: 1344 AEAHAQAKAQAEREAKELQQ---RMQEEVVRREEA---AVDAQQQKRSIQEELQQLRQSS 1397

Query: 478  TPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQR 537
                   A +     R+ L   +  +++     A              LR   +E E Q+
Sbjct: 1398 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1457

Query: 538  LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERL--------RKVLQARERVEQMKE 589
             +    +EEAE+LRRQ  +E +R+R  EV+L    +         ++ LQA E +    E
Sbjct: 1458 RQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1514

Query: 590  EKKKQIEQ----KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 645
            E ++++ Q    +  Q+    E A+    AE ++K+ + A+K  ++E  R  +EE   + 
Sbjct: 1515 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE--RSLQEEHVAVA 1572

Query: 646  WLQQEEEERRHQELLQKKKEEEQER-----LRKAAEAKRL---AEQREQERREQERREQE 697
             L++E E R  Q+   ++  EE ER       KA EA RL   AE+  Q++   +   ++
Sbjct: 1573 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1632

Query: 698  RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
            ++E+  RE  RR +  + A ++R   ++ L+ +R+L E     RL  EQ    L  + ++
Sbjct: 1633 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1692

Query: 758  EEQQRLAERQLQEEQEKKAKEAAGASK 784
             EQQR   + L+EE  +  +EAA A++
Sbjct: 1693 GEQQR---QLLEEELARLQREAAAATQ 1716



 Score = 96.7 bits (239), Expect = 9e-20
 Identities = 150/595 (25%), Positives = 258/595 (43%), Gaps = 118/595 (19%)

Query: 296  SRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAK-QESVVRRASRRL----AKKTAEEPAAS 350
            +  + QS R S    ++   + L +++  VA+ +E   RRA ++     A++ AE     
Sbjct: 1542 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601

Query: 351  GRIICHSYLE-RLLNVEVPQKVG---SEQKEPPEEAEPVA-----AAEPEVPENNGNNSW 401
             ++  +  L  RL   EV Q+     +E ++  EEAE  A     A E  V +       
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1661

Query: 402  PHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELD 461
                 ++A  T   + AA         +  A+T+Q +  R+  +     R  ++A +   
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELI----RLRAETEQGEQQRQLLEE-ELARLQREAAAATQ 1716

Query: 462  EEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK 521
            + Q LE  EL   R++        ++     R+   T ++++  +    A     +   +
Sbjct: 1717 KRQELE-AELAKVRAEMEVLLASKARAEEESRS---TSEKSKQRL---EAEAGRFRELAE 1769

Query: 522  RNTPLRMDPKEKERQRL----ENLRRKEEAEQLRRQKV----EEDKRRRLEEVKLKREE- 572
                LR   +E +RQR     +  R++ EAE++  +K+    E  + +   E+ LK +E 
Sbjct: 1770 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1829

Query: 573  ---RLRKVLQ----ARERVEQMKEEKKKQIEQKFAQI----DEKTEKAK----------- 610
               RLR++ +     R R+E+   + K  IE++ AQ+    D + E+ K           
Sbjct: 1830 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1889

Query: 611  ---EERLAEEKAKKKAAAKKME--------------EVEARRKQEEEARRLRWLQQEEEE 653
               EE LA + + +KAAA K E               + ++ + E EA R R L  EEE 
Sbjct: 1890 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1949

Query: 654  RRHQ--ELLQKK--KEEEQERLRKAA------------EAKRLAEQREQERREQ------ 691
            RR +  E +QK    EEE  R RKAA            EA+RL E+ EQE   Q      
Sbjct: 1950 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2009

Query: 692  -----------------ERREQERREQERREQERREQERQLAEQERR----REQERLQAE 730
                             +++EQE ++  ++EQ   +Q R  AE  RR     E+ R+QAE
Sbjct: 2010 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2069

Query: 731  RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKA 785
            RE  +  + +  + E+L++  EE+ +   Q + A  +L++E E++A   A A +A
Sbjct: 2070 REAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2123



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 75/243 (30%), Positives = 127/243 (52%), Gaps = 22/243 (9%)

Query: 539  ENLRRKEEAE---QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQI 595
            + LR KE+AE     +RQ   E++RRR E      EER++K L A E   + ++   +++
Sbjct: 1925 DTLRSKEQAELEAARQRQLAAEEERRRREA-----EERVQKSLAAEEEAARQRKAALEEV 1979

Query: 596  EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 655
            E+  A+++E   +   ER  +E A++   A   +E   +R Q EE      +QQ+E+E  
Sbjct: 1980 ERLKAKVEEA--RRLRERAEQESARQLQLA---QEAAQKRLQAEEKAHAFAVQQKEQEL- 2033

Query: 656  HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ----ERREQERREQ 711
             Q+ LQ+++    +   +A  A+R AE+ E+ R + ER   + R Q    ER +Q   EQ
Sbjct: 2034 -QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2092

Query: 712  ERQLAEQERRREQERLQAERELQER---EKALRLQKEQLQRELEEKKKKEEQQRLAERQL 768
             +  A+ +   E+ R +AE+E   R   E+A   QK+    E+E+ KK  EQ    + Q+
Sbjct: 2093 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2152

Query: 769  QEE 771
            ++E
Sbjct: 2153 EQE 2155



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 87/327 (26%), Positives = 161/327 (49%), Gaps = 29/327 (8%)

Query: 531  KEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRL---EEVKLKREERLRKVLQARERVE 585
            + KE+  LE  R+++ A  E+ RR++ EE  ++ L   EE   +R+  L +V + + +VE
Sbjct: 1928 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1987

Query: 586  QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE------ 639
            + +  +++  ++   Q+    E A++   AEEKA   A  +K +E++   +QE+      
Sbjct: 1988 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2047

Query: 640  --EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 697
              EA   R   +E EE R    +Q ++E  Q R R+  EA+RL +Q  +E+ +   + Q 
Sbjct: 2048 RGEAEAARRAAEEAEEAR----VQAEREAAQSR-RQVEEAERL-KQSAEEQAQARAQAQA 2101

Query: 698  RREQERREQERREQERQLAEQERRREQERLQAERELQER--EKALRLQKEQLQRELEEKK 755
              E+ R+E E+    R  AEQ   R+++   AE E  ++  E+ LR QK Q+++EL   +
Sbjct: 2102 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTTLR 2160

Query: 756  KKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINP 815
             + E+    +  L EE ++   EA  A++  +    V+    +      +  +   +I  
Sbjct: 2161 LQLEETDHQKNLLDEELQRLKAEATEAARQRS---QVEEELFSVRVQMEELSKLKARIEA 2217

Query: 816  DNYGMDLNSDDST----DDEAHPRKPI 838
            +N  + L   D+T     +EA   K +
Sbjct: 2218 ENRALILRDKDNTQRFLQEEAEKMKQV 2244



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 77/277 (27%), Positives = 135/277 (48%), Gaps = 18/277 (6%)

Query: 513  RSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 572
            R + ++  +       + KE +++  E + R+EEA        ++ KR   EE++  R+ 
Sbjct: 1341 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV----DAQQQKRSIQEELQQLRQS 1396

Query: 573  RLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVE 632
               ++ QA+ R  +  E  + +IE++   +  + E  + +R   E  + +A   + EE E
Sbjct: 1397 SEAEI-QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-GELQALRARAEEAE 1454

Query: 633  A--RRKQEEEARRLRWLQQEEEERRHQ---ELLQKKKEE-----EQERLRKAAEAKRLAE 682
            A  R+ Q EEA RLR   Q+E +R+ Q   EL  + K E     E++R  +A E  RL  
Sbjct: 1455 AQKRQAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1513

Query: 683  QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRL 742
            +  + R  Q   E+ R+ Q   E  +R  E +L  +     ++  Q ER LQE   A+  
Sbjct: 1514 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1573

Query: 743  QKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
             +E+ +R  +++ + E  +  AER+L E  + KA EA
Sbjct: 1574 LREEAERRAQQQAEAERAREEAEREL-ERWQLKANEA 1609



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 138/560 (24%), Positives = 235/560 (41%), Gaps = 117/560 (20%)

Query: 316  QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
            Q L Q+ S++ +       A+RR A++  E    + R    S   R    E  +   S +
Sbjct: 2035 QTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQS---RRQVEEAERLKQSAE 2090

Query: 376  KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTD 435
            ++    A+  AAAE    E          + E A      + A    +   A  ++ K  
Sbjct: 2091 EQAQARAQAQAAAEKLRKEA---------EQEAARRAQAEQAALRQKQAADAEMEKHKKF 2141

Query: 436  QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF 495
                 R+  Q  +   + +  + E D +++L DEELQ  +++   +    S+V   L + 
Sbjct: 2142 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2201

Query: 496  LHTVQRNQMLMTPTSAPRSVMKSFIKRNTP-LRMDPKEKERQRLENLRR----KEEAEQL 550
               ++    L     A    +    K NT     +  EK +Q  E   R     +EA +L
Sbjct: 2202 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2261

Query: 551  RRQKVEED--KRRRLEEVKLKREERLRKVLQAR------ERVEQMKE----------EKK 592
            R Q  EED  ++R L E  LK  E+++ V +A       E ++Q KE          E K
Sbjct: 2262 R-QLAEEDLAQQRALAEKMLK--EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2318

Query: 593  KQIEQKFAQIDE---KTEKAKEERLAEEKAKKKAAAKKMEEVE-ARRKQEEEARRLRWLQ 648
            +Q+ Q+ A+  +   +T +A+ +R  E  A+ +    ++ E+  A+ + EE+A+R R   
Sbjct: 2319 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2378

Query: 649  QEEEERRHQ---------------ELLQKKKEEEQERLRKA-AEAKRLAEQREQERR--- 689
            +E  E+ H+               E+ +++ + + ERLR+A AE +R  E+ +QE +   
Sbjct: 2379 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2438

Query: 690  ---------------------------------------EQERREQER-------REQER 703
                                                   EQE+ + E+       + Q+ 
Sbjct: 2439 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2498

Query: 704  REQERREQERQLAEQERRR------EQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
            RE+++R+Q++   EQER+R      E  R Q E E   R K   LQ+ + QR  +E+   
Sbjct: 2499 REEQQRQQQQM--EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2556

Query: 758  EEQQRLAER-QLQEEQEKKA 776
            EE QRL E+ QL EEQ + A
Sbjct: 2557 EENQRLREQLQLLEEQHRAA 2576



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 98/403 (24%), Positives = 185/403 (45%), Gaps = 53/403 (13%)

Query: 445  QSARRKRSYKQAVSELDEEQHLED--------EELQPPRSKTPSSPCPASKVVRPLRTFL 496
            Q ARR++   QA+   D +   E         EE++    K       A + +  ++ + 
Sbjct: 1192 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1251

Query: 497  HTVQRNQMLMTPTSAP------RSVMKSFIKRNTPLRMDPKEKERQRL-------ENLRR 543
              +   +  + P ++P      +S  +S I+    LR    E             E LRR
Sbjct: 1252 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1311

Query: 544  KEEAEQLRRQKVEEDKRRRLE-EVKLKREERLRKV-LQARERVEQMKEEKKKQIEQKFAQ 601
             EE E+L  Q+  E++ R  E E  L+++ +L +   QA+ + E+  +E +++++++  +
Sbjct: 1312 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371

Query: 602  IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQ 661
             +E    A++++ + ++  ++       E++A+ +Q E A R R L+ EEE R     + 
Sbjct: 1372 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIR-----VV 1425

Query: 662  KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 721
            + + E  ER R  AE     E +    R +E   Q+R+ QE  E+ RR    Q+ ++ +R
Sbjct: 1426 RLQLEATERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRR----QVQDESQR 1477

Query: 722  REQ------ERLQAERE-LQEREKA------LRLQKEQLQREL---EEKKKKEEQQRLAE 765
            + Q       R++AE E  +E+++A      LRLQ E+ +R L   E ++ ++ Q  L  
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1537

Query: 766  RQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHR 808
             Q   E E ++K A+ A K   +   +Q       Q+  +  R
Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER 1580



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 120/544 (22%), Positives = 218/544 (40%), Gaps = 79/544 (14%)

Query: 299  DSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSY 358
            +SQ  R + +  +S   +V A+  +   KQ ++      RL  + AE      R +  + 
Sbjct: 1474 ESQRKRQAEVELAS---RVKAEAEAAREKQRALQALEELRLQAEEAE------RRLRQAE 1524

Query: 359  LERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
            +ER   V+V  +      E   +++  + AE          S       +A      +  
Sbjct: 1525 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR 1581

Query: 419  ASSPETPSAGQQEA---------KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
            A         ++EA         K ++A   R   +   +++S  QA +E  +E   E E
Sbjct: 1582 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---EAE 1638

Query: 470  ELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMD 529
                 R K         + VR        +++ + L   T+  R   +  + R   LR +
Sbjct: 1639 REARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR---LRAE 1689

Query: 530  PKEKERQR------LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER 583
             ++ E+QR      L  L+R+  A   +RQ++E +    L +V+ + E  L    +A E 
Sbjct: 1690 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----LAKVRAEMEVLLASKARAEEE 1745

Query: 584  VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE--- 640
                 E+ K+++E +  +  E  E+A   R   E+AK++   +  EE  AR++ E E   
Sbjct: 1746 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--QLAEEDAARQRAEAERVL 1803

Query: 641  ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 700
            A +L  + +    +   E+  K+KE E ERLR+ AE +    +R +E+  Q + + E R 
Sbjct: 1804 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1863

Query: 701  QERREQERREQERQLA------EQERRREQE-------------------------RLQA 729
             + R+    E ERQ         Q R+ E+E                         R  A
Sbjct: 1864 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1923

Query: 730  ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVT 789
            E  L+ +E+A      Q Q   EE++++ E +   ++ L  E+E   +  A   +   + 
Sbjct: 1924 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 1983

Query: 790  VDVQ 793
              V+
Sbjct: 1984 AKVE 1987



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 119/525 (22%), Positives = 224/525 (42%), Gaps = 92/525 (17%)

Query: 319  AQKYSLVAKQESVVRRASRRLAKK-TAEEPAASGRIICHSYLERLL-------------- 363
            A++  L A++E   R A  R+ K   AEE AA  R      +ERL               
Sbjct: 1938 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 1997

Query: 364  -----NVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
                  +++ Q+   ++ +  E+A   A  + E        +     + +       + A
Sbjct: 1998 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAA 2054

Query: 419  ASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKT 478
              + E     + +A+ + A   R+  ++ R K+S ++      + Q   ++  +    + 
Sbjct: 2055 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114

Query: 479  PSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRL 538
                      +R  +     +++++     T   ++ ++  +   T LR+  +E + Q+ 
Sbjct: 2115 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL---TTLRLQLEETDHQKN 2171

Query: 539  ---ENLRR-KEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ 594
               E L+R K EA +  RQ+ + ++      V+++   +L+  ++A  R   +++   K 
Sbjct: 2172 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---KD 2228

Query: 595  IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEER 654
              Q+F Q  E+ EK K+  +AEE A+   AA             +EA RLR L +E+  +
Sbjct: 2229 NTQRFLQ--EEAEKMKQ--VAEEAARLSVAA-------------QEAARLRQLAEEDLAQ 2271

Query: 655  RH---QELLQKKKEEEQERLRKAAEAKRLAEQR----EQERREQERREQERRE------- 700
            +    +++L++K +  QE  R  AEA+ L +Q+    EQ RR QE +EQ  ++       
Sbjct: 2272 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2331

Query: 701  -QERREQERREQERQLAEQER-------------RREQE----RLQAER--------ELQ 734
             Q   E ER+ Q    AE ER             R E++    R QAE         EL 
Sbjct: 2332 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2391

Query: 735  EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
             +EK   +Q  ++QR+  +   +  ++ +AE  L+ E+EK  +EA
Sbjct: 2392 TQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKEKLQQEA 2434



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 70/275 (25%), Positives = 129/275 (46%), Gaps = 16/275 (5%)

Query: 532  EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKL--KREERLRKVLQARERVEQMKE 589
            E ERQR   +  + E  +LR  ++   + R  E+ +   K+ E + + L   E   Q K 
Sbjct: 2337 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2396

Query: 590  EKKKQIEQKFAQIDEKTEKAKEE--RLAEEKAKKKAAAK--KMEEVEARRKQEEEARRLR 645
               + +E +  Q D   E+ +E    L  EK K +  AK  +++  E +  Q+E+  +  
Sbjct: 2397 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2456

Query: 646  WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR- 704
               Q+        LLQ+++  EQE+ +     +    + +Q R EQ+R++Q+  ++ +R 
Sbjct: 2457 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2516

Query: 705  ---EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 761
                +E R ++ +  E  RR+++E  Q E++ +++E+ L    E+ QR  E+ +  EEQ 
Sbjct: 2517 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL---AEENQRLREQLQLLEEQH 2573

Query: 762  RLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPA 796
            R A   L   +E  A + A      N    +  PA
Sbjct: 2574 RAA---LAHSEEVTASQVAATKTLPNGRDALDGPA 2605



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 80/345 (23%), Positives = 153/345 (44%), Gaps = 46/345 (13%)

Query: 433  KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPL 492
            +T +A+  R+   SA  +R  K  V+E+   Q   +E+ Q  R +       A ++   L
Sbjct: 2334 RTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEEDAQRFRKQ-------AEEIGEKL 2385

Query: 493  -RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLR 551
             RT L T ++  ++ T                  ++    + + +RL     + E E+ +
Sbjct: 2386 HRTELATQEKVTLVQT----------------LEIQRQQSDHDAERLREAIAELEREKEK 2429

Query: 552  RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 611
             Q+  +  + + EE++  ++E+L   LQ  + ++Q    +K  + Q+   I++  EKAK 
Sbjct: 2430 LQQEAKLLQLKSEEMQTVQQEQL---LQETQALQQSFLSEKDSLLQRERFIEQ--EKAKL 2484

Query: 612  ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL 671
            E+L +++  K   A+++ E + R++Q+ E  R R +   EE RR Q   ++    +QE L
Sbjct: 2485 EQLFQDEVAK---AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2541

Query: 672  RKAAEAKRLAEQREQERREQERREQERREQERRE-QERREQERQLAEQERRREQERLQAE 730
                      +Q EQ+RR+QE    E  ++ R + Q   EQ R            ++ A 
Sbjct: 2542 ----------QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2591

Query: 731  RELQEREKAL--RLQKEQLQRELEEKKKKEEQQRLAERQLQEEQE 773
            + L     AL     + + +   +  ++K   QRL E  +   +E
Sbjct: 2592 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2636



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 61/278 (21%), Positives = 128/278 (46%), Gaps = 35/278 (12%)

Query: 541  LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR---KVLQARERVEQMKEEKKKQIEQ 597
            +R  + AE++ R   E+ K  +     L   E  +   K L+A+   +Q   +  +   +
Sbjct: 1063 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1122

Query: 598  KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA--------RRKQEEEARRLRWLQQ 649
               ++ E+ ++   ER  E +  ++  A+ +E  +A        +R+ E+  R+LR+ + 
Sbjct: 1123 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR- 1181

Query: 650  EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR--EQERREQERREQERREQE 707
            E  +     L   ++ +EQ +    A+++ + EQ  QE+   E+  R  E+ E+ +R  +
Sbjct: 1182 ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1241

Query: 708  R-----REQERQLAEQERRRE-------QERLQ--AERELQE-------REKALRLQKEQ 746
            +     ++ E QL   + + E       + ++Q  +E  +QE         +   L  + 
Sbjct: 1242 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1301

Query: 747  LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 784
            ++   E  ++ EE++RLAE+Q  EE+E+ A+  A   K
Sbjct: 1302 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1339


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  102 bits (253), Expect = 2e-21
 Identities = 100/387 (25%), Positives = 182/387 (47%), Gaps = 34/387 (8%)

Query: 418  AASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK 477
            A +  +  +  ++EAK  Q    R   +  RR+ +   AV    +++ +++E  Q  +S 
Sbjct: 1513 AEAHAQAKAQAEREAKELQQ---RMQEEVVRREEA---AVDAQQQKRSIQEELQQLRQSS 1566

Query: 478  TPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQR 537
                   A +     R+ L   +  +++     A              LR   +E E Q+
Sbjct: 1567 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1626

Query: 538  LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERL--------RKVLQARERVEQMKE 589
             +    +EEAE+LRRQ  +E +R+R  EV+L    +         ++ LQA E +    E
Sbjct: 1627 RQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1683

Query: 590  EKKKQIEQ----KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 645
            E ++++ Q    +  Q+    E A+    AE ++K+ + A+K  ++E  R  +EE   + 
Sbjct: 1684 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE--RSLQEEHVAVA 1741

Query: 646  WLQQEEEERRHQELLQKKKEEEQER-----LRKAAEAKRL---AEQREQERREQERREQE 697
             L++E E R  Q+   ++  EE ER       KA EA RL   AE+  Q++   +   ++
Sbjct: 1742 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1801

Query: 698  RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
            ++E+  RE  RR +  + A ++R   ++ L+ +R+L E     RL  EQ    L  + ++
Sbjct: 1802 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1861

Query: 758  EEQQRLAERQLQEEQEKKAKEAAGASK 784
             EQQR   + L+EE  +  +EAA A++
Sbjct: 1862 GEQQR---QLLEEELARLQREAAAATQ 1885



 Score = 96.7 bits (239), Expect = 9e-20
 Identities = 150/595 (25%), Positives = 258/595 (43%), Gaps = 118/595 (19%)

Query: 296  SRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAK-QESVVRRASRRL----AKKTAEEPAAS 350
            +  + QS R S    ++   + L +++  VA+ +E   RRA ++     A++ AE     
Sbjct: 1711 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770

Query: 351  GRIICHSYLE-RLLNVEVPQKVG---SEQKEPPEEAEPVA-----AAEPEVPENNGNNSW 401
             ++  +  L  RL   EV Q+     +E ++  EEAE  A     A E  V +       
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830

Query: 402  PHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELD 461
                 ++A  T   + AA         +  A+T+Q +  R+  +     R  ++A +   
Sbjct: 1831 LEKQRQLAEGTAQQRLAAEQELI----RLRAETEQGEQQRQLLEE-ELARLQREAAAATQ 1885

Query: 462  EEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK 521
            + Q LE  EL   R++        ++     R+   T ++++  +    A     +   +
Sbjct: 1886 KRQELE-AELAKVRAEMEVLLASKARAEEESRS---TSEKSKQRL---EAEAGRFRELAE 1938

Query: 522  RNTPLRMDPKEKERQRL----ENLRRKEEAEQLRRQKV----EEDKRRRLEEVKLKREE- 572
                LR   +E +RQR     +  R++ EAE++  +K+    E  + +   E+ LK +E 
Sbjct: 1939 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998

Query: 573  ---RLRKVLQ----ARERVEQMKEEKKKQIEQKFAQI----DEKTEKAK----------- 610
               RLR++ +     R R+E+   + K  IE++ AQ+    D + E+ K           
Sbjct: 1999 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 2058

Query: 611  ---EERLAEEKAKKKAAAKKME--------------EVEARRKQEEEARRLRWLQQEEEE 653
               EE LA + + +KAAA K E               + ++ + E EA R R L  EEE 
Sbjct: 2059 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 2118

Query: 654  RRHQ--ELLQKK--KEEEQERLRKAA------------EAKRLAEQREQERREQ------ 691
            RR +  E +QK    EEE  R RKAA            EA+RL E+ EQE   Q      
Sbjct: 2119 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2178

Query: 692  -----------------ERREQERREQERREQERREQERQLAEQERR----REQERLQAE 730
                             +++EQE ++  ++EQ   +Q R  AE  RR     E+ R+QAE
Sbjct: 2179 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2238

Query: 731  RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKA 785
            RE  +  + +  + E+L++  EE+ +   Q + A  +L++E E++A   A A +A
Sbjct: 2239 REAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2292



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 75/243 (30%), Positives = 127/243 (52%), Gaps = 22/243 (9%)

Query: 539  ENLRRKEEAE---QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQI 595
            + LR KE+AE     +RQ   E++RRR E      EER++K L A E   + ++   +++
Sbjct: 2094 DTLRSKEQAELEAARQRQLAAEEERRRREA-----EERVQKSLAAEEEAARQRKAALEEV 2148

Query: 596  EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 655
            E+  A+++E   +   ER  +E A++   A   +E   +R Q EE      +QQ+E+E  
Sbjct: 2149 ERLKAKVEEA--RRLRERAEQESARQLQLA---QEAAQKRLQAEEKAHAFAVQQKEQEL- 2202

Query: 656  HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ----ERREQERREQ 711
             Q+ LQ+++    +   +A  A+R AE+ E+ R + ER   + R Q    ER +Q   EQ
Sbjct: 2203 -QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2261

Query: 712  ERQLAEQERRREQERLQAERELQER---EKALRLQKEQLQRELEEKKKKEEQQRLAERQL 768
             +  A+ +   E+ R +AE+E   R   E+A   QK+    E+E+ KK  EQ    + Q+
Sbjct: 2262 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2321

Query: 769  QEE 771
            ++E
Sbjct: 2322 EQE 2324



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 87/327 (26%), Positives = 161/327 (49%), Gaps = 29/327 (8%)

Query: 531  KEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRL---EEVKLKREERLRKVLQARERVE 585
            + KE+  LE  R+++ A  E+ RR++ EE  ++ L   EE   +R+  L +V + + +VE
Sbjct: 2097 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2156

Query: 586  QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE------ 639
            + +  +++  ++   Q+    E A++   AEEKA   A  +K +E++   +QE+      
Sbjct: 2157 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2216

Query: 640  --EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 697
              EA   R   +E EE R    +Q ++E  Q R R+  EA+RL +Q  +E+ +   + Q 
Sbjct: 2217 RGEAEAARRAAEEAEEAR----VQAEREAAQSR-RQVEEAERL-KQSAEEQAQARAQAQA 2270

Query: 698  RREQERREQERREQERQLAEQERRREQERLQAERELQER--EKALRLQKEQLQRELEEKK 755
              E+ R+E E+    R  AEQ   R+++   AE E  ++  E+ LR QK Q+++EL   +
Sbjct: 2271 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTTLR 2329

Query: 756  KKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINP 815
             + E+    +  L EE ++   EA  A++  +    V+    +      +  +   +I  
Sbjct: 2330 LQLEETDHQKNLLDEELQRLKAEATEAARQRS---QVEEELFSVRVQMEELSKLKARIEA 2386

Query: 816  DNYGMDLNSDDST----DDEAHPRKPI 838
            +N  + L   D+T     +EA   K +
Sbjct: 2387 ENRALILRDKDNTQRFLQEEAEKMKQV 2413



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 77/277 (27%), Positives = 135/277 (48%), Gaps = 18/277 (6%)

Query: 513  RSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 572
            R + ++  +       + KE +++  E + R+EEA        ++ KR   EE++  R+ 
Sbjct: 1510 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV----DAQQQKRSIQEELQQLRQS 1565

Query: 573  RLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVE 632
               ++ QA+ R  +  E  + +IE++   +  + E  + +R   E  + +A   + EE E
Sbjct: 1566 SEAEI-QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-GELQALRARAEEAE 1623

Query: 633  A--RRKQEEEARRLRWLQQEEEERRHQ---ELLQKKKEE-----EQERLRKAAEAKRLAE 682
            A  R+ Q EEA RLR   Q+E +R+ Q   EL  + K E     E++R  +A E  RL  
Sbjct: 1624 AQKRQAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1682

Query: 683  QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRL 742
            +  + R  Q   E+ R+ Q   E  +R  E +L  +     ++  Q ER LQE   A+  
Sbjct: 1683 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1742

Query: 743  QKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
             +E+ +R  +++ + E  +  AER+L E  + KA EA
Sbjct: 1743 LREEAERRAQQQAEAERAREEAEREL-ERWQLKANEA 1778



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 138/560 (24%), Positives = 235/560 (41%), Gaps = 117/560 (20%)

Query: 316  QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
            Q L Q+ S++ +       A+RR A++  E    + R    S   R    E  +   S +
Sbjct: 2204 QTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQS---RRQVEEAERLKQSAE 2259

Query: 376  KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTD 435
            ++    A+  AAAE    E          + E A      + A    +   A  ++ K  
Sbjct: 2260 EQAQARAQAQAAAEKLRKEA---------EQEAARRAQAEQAALRQKQAADAEMEKHKKF 2310

Query: 436  QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF 495
                 R+  Q  +   + +  + E D +++L DEELQ  +++   +    S+V   L + 
Sbjct: 2311 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2370

Query: 496  LHTVQRNQMLMTPTSAPRSVMKSFIKRNTP-LRMDPKEKERQRLENLRR----KEEAEQL 550
               ++    L     A    +    K NT     +  EK +Q  E   R     +EA +L
Sbjct: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2430

Query: 551  RRQKVEED--KRRRLEEVKLKREERLRKVLQAR------ERVEQMKE----------EKK 592
            R Q  EED  ++R L E  LK  E+++ V +A       E ++Q KE          E K
Sbjct: 2431 R-QLAEEDLAQQRALAEKMLK--EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2487

Query: 593  KQIEQKFAQIDE---KTEKAKEERLAEEKAKKKAAAKKMEEVE-ARRKQEEEARRLRWLQ 648
            +Q+ Q+ A+  +   +T +A+ +R  E  A+ +    ++ E+  A+ + EE+A+R R   
Sbjct: 2488 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2547

Query: 649  QEEEERRHQ---------------ELLQKKKEEEQERLRKA-AEAKRLAEQREQERR--- 689
            +E  E+ H+               E+ +++ + + ERLR+A AE +R  E+ +QE +   
Sbjct: 2548 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2607

Query: 690  ---------------------------------------EQERREQER-------REQER 703
                                                   EQE+ + E+       + Q+ 
Sbjct: 2608 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2667

Query: 704  REQERREQERQLAEQERRR------EQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
            RE+++R+Q++   EQER+R      E  R Q E E   R K   LQ+ + QR  +E+   
Sbjct: 2668 REEQQRQQQQM--EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2725

Query: 758  EEQQRLAER-QLQEEQEKKA 776
            EE QRL E+ QL EEQ + A
Sbjct: 2726 EENQRLREQLQLLEEQHRAA 2745



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 98/403 (24%), Positives = 185/403 (45%), Gaps = 53/403 (13%)

Query: 445  QSARRKRSYKQAVSELDEEQHLED--------EELQPPRSKTPSSPCPASKVVRPLRTFL 496
            Q ARR++   QA+   D +   E         EE++    K       A + +  ++ + 
Sbjct: 1361 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1420

Query: 497  HTVQRNQMLMTPTSAP------RSVMKSFIKRNTPLRMDPKEKERQRL-------ENLRR 543
              +   +  + P ++P      +S  +S I+    LR    E             E LRR
Sbjct: 1421 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1480

Query: 544  KEEAEQLRRQKVEEDKRRRLE-EVKLKREERLRKV-LQARERVEQMKEEKKKQIEQKFAQ 601
             EE E+L  Q+  E++ R  E E  L+++ +L +   QA+ + E+  +E +++++++  +
Sbjct: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540

Query: 602  IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQ 661
             +E    A++++ + ++  ++       E++A+ +Q E A R R L+ EEE R     + 
Sbjct: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIR-----VV 1594

Query: 662  KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 721
            + + E  ER R  AE     E +    R +E   Q+R+ QE  E+ RR    Q+ ++ +R
Sbjct: 1595 RLQLEATERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRR----QVQDESQR 1646

Query: 722  REQ------ERLQAERE-LQEREKA------LRLQKEQLQREL---EEKKKKEEQQRLAE 765
            + Q       R++AE E  +E+++A      LRLQ E+ +R L   E ++ ++ Q  L  
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1706

Query: 766  RQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHR 808
             Q   E E ++K A+ A K   +   +Q       Q+  +  R
Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER 1749



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 120/544 (22%), Positives = 218/544 (40%), Gaps = 79/544 (14%)

Query: 299  DSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSY 358
            +SQ  R + +  +S   +V A+  +   KQ ++      RL  + AE      R +  + 
Sbjct: 1643 ESQRKRQAEVELAS---RVKAEAEAAREKQRALQALEELRLQAEEAE------RRLRQAE 1693

Query: 359  LERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
            +ER   V+V  +      E   +++  + AE          S       +A      +  
Sbjct: 1694 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR 1750

Query: 419  ASSPETPSAGQQEA---------KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
            A         ++EA         K ++A   R   +   +++S  QA +E  +E   E E
Sbjct: 1751 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---EAE 1807

Query: 470  ELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMD 529
                 R K         + VR        +++ + L   T+  R   +  + R   LR +
Sbjct: 1808 REARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR---LRAE 1858

Query: 530  PKEKERQR------LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER 583
             ++ E+QR      L  L+R+  A   +RQ++E +    L +V+ + E  L    +A E 
Sbjct: 1859 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----LAKVRAEMEVLLASKARAEEE 1914

Query: 584  VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE--- 640
                 E+ K+++E +  +  E  E+A   R   E+AK++   +  EE  AR++ E E   
Sbjct: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--QLAEEDAARQRAEAERVL 1972

Query: 641  ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 700
            A +L  + +    +   E+  K+KE E ERLR+ AE +    +R +E+  Q + + E R 
Sbjct: 1973 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 2032

Query: 701  QERREQERREQERQLA------EQERRREQE-------------------------RLQA 729
             + R+    E ERQ         Q R+ E+E                         R  A
Sbjct: 2033 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 2092

Query: 730  ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVT 789
            E  L+ +E+A      Q Q   EE++++ E +   ++ L  E+E   +  A   +   + 
Sbjct: 2093 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2152

Query: 790  VDVQ 793
              V+
Sbjct: 2153 AKVE 2156



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 119/525 (22%), Positives = 224/525 (42%), Gaps = 92/525 (17%)

Query: 319  AQKYSLVAKQESVVRRASRRLAKK-TAEEPAASGRIICHSYLERLL-------------- 363
            A++  L A++E   R A  R+ K   AEE AA  R      +ERL               
Sbjct: 2107 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2166

Query: 364  -----NVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
                  +++ Q+   ++ +  E+A   A  + E        +     + +       + A
Sbjct: 2167 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAA 2223

Query: 419  ASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKT 478
              + E     + +A+ + A   R+  ++ R K+S ++      + Q   ++  +    + 
Sbjct: 2224 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283

Query: 479  PSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRL 538
                      +R  +     +++++     T   ++ ++  +   T LR+  +E + Q+ 
Sbjct: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL---TTLRLQLEETDHQKN 2340

Query: 539  ---ENLRR-KEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ 594
               E L+R K EA +  RQ+ + ++      V+++   +L+  ++A  R   +++   K 
Sbjct: 2341 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---KD 2397

Query: 595  IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEER 654
              Q+F Q  E+ EK K+  +AEE A+   AA             +EA RLR L +E+  +
Sbjct: 2398 NTQRFLQ--EEAEKMKQ--VAEEAARLSVAA-------------QEAARLRQLAEEDLAQ 2440

Query: 655  RH---QELLQKKKEEEQERLRKAAEAKRLAEQR----EQERREQERREQERRE------- 700
            +    +++L++K +  QE  R  AEA+ L +Q+    EQ RR QE +EQ  ++       
Sbjct: 2441 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2500

Query: 701  -QERREQERREQERQLAEQER-------------RREQE----RLQAER--------ELQ 734
             Q   E ER+ Q    AE ER             R E++    R QAE         EL 
Sbjct: 2501 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2560

Query: 735  EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
             +EK   +Q  ++QR+  +   +  ++ +AE  L+ E+EK  +EA
Sbjct: 2561 TQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKEKLQQEA 2603



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 70/275 (25%), Positives = 129/275 (46%), Gaps = 16/275 (5%)

Query: 532  EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKL--KREERLRKVLQARERVEQMKE 589
            E ERQR   +  + E  +LR  ++   + R  E+ +   K+ E + + L   E   Q K 
Sbjct: 2506 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2565

Query: 590  EKKKQIEQKFAQIDEKTEKAKEE--RLAEEKAKKKAAAK--KMEEVEARRKQEEEARRLR 645
               + +E +  Q D   E+ +E    L  EK K +  AK  +++  E +  Q+E+  +  
Sbjct: 2566 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2625

Query: 646  WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR- 704
               Q+        LLQ+++  EQE+ +     +    + +Q R EQ+R++Q+  ++ +R 
Sbjct: 2626 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2685

Query: 705  ---EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 761
                +E R ++ +  E  RR+++E  Q E++ +++E+ L    E+ QR  E+ +  EEQ 
Sbjct: 2686 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL---AEENQRLREQLQLLEEQH 2742

Query: 762  RLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPA 796
            R A   L   +E  A + A      N    +  PA
Sbjct: 2743 RAA---LAHSEEVTASQVAATKTLPNGRDALDGPA 2774



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 80/345 (23%), Positives = 153/345 (44%), Gaps = 46/345 (13%)

Query: 433  KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPL 492
            +T +A+  R+   SA  +R  K  V+E+   Q   +E+ Q  R +       A ++   L
Sbjct: 2503 RTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEEDAQRFRKQ-------AEEIGEKL 2554

Query: 493  -RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLR 551
             RT L T ++  ++ T                  ++    + + +RL     + E E+ +
Sbjct: 2555 HRTELATQEKVTLVQT----------------LEIQRQQSDHDAERLREAIAELEREKEK 2598

Query: 552  RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 611
             Q+  +  + + EE++  ++E+L   LQ  + ++Q    +K  + Q+   I++  EKAK 
Sbjct: 2599 LQQEAKLLQLKSEEMQTVQQEQL---LQETQALQQSFLSEKDSLLQRERFIEQ--EKAKL 2653

Query: 612  ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL 671
            E+L +++  K   A+++ E + R++Q+ E  R R +   EE RR Q   ++    +QE L
Sbjct: 2654 EQLFQDEVAK---AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2710

Query: 672  RKAAEAKRLAEQREQERREQERREQERREQERRE-QERREQERQLAEQERRREQERLQAE 730
                      +Q EQ+RR+QE    E  ++ R + Q   EQ R            ++ A 
Sbjct: 2711 ----------QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2760

Query: 731  RELQEREKAL--RLQKEQLQRELEEKKKKEEQQRLAERQLQEEQE 773
            + L     AL     + + +   +  ++K   QRL E  +   +E
Sbjct: 2761 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2805



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 61/278 (21%), Positives = 128/278 (46%), Gaps = 35/278 (12%)

Query: 541  LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR---KVLQARERVEQMKEEKKKQIEQ 597
            +R  + AE++ R   E+ K  +     L   E  +   K L+A+   +Q   +  +   +
Sbjct: 1232 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1291

Query: 598  KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA--------RRKQEEEARRLRWLQQ 649
               ++ E+ ++   ER  E +  ++  A+ +E  +A        +R+ E+  R+LR+ + 
Sbjct: 1292 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR- 1350

Query: 650  EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR--EQERREQERREQERREQE 707
            E  +     L   ++ +EQ +    A+++ + EQ  QE+   E+  R  E+ E+ +R  +
Sbjct: 1351 ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1410

Query: 708  R-----REQERQLAEQERRRE-------QERLQ--AERELQE-------REKALRLQKEQ 746
            +     ++ E QL   + + E       + ++Q  +E  +QE         +   L  + 
Sbjct: 1411 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1470

Query: 747  LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 784
            ++   E  ++ EE++RLAE+Q  EE+E+ A+  A   K
Sbjct: 1471 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1508


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  102 bits (253), Expect = 2e-21
 Identities = 100/387 (25%), Positives = 182/387 (47%), Gaps = 34/387 (8%)

Query: 418  AASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK 477
            A +  +  +  ++EAK  Q    R   +  RR+ +   AV    +++ +++E  Q  +S 
Sbjct: 1354 AEAHAQAKAQAEREAKELQQ---RMQEEVVRREEA---AVDAQQQKRSIQEELQQLRQSS 1407

Query: 478  TPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQR 537
                   A +     R+ L   +  +++     A              LR   +E E Q+
Sbjct: 1408 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1467

Query: 538  LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERL--------RKVLQARERVEQMKE 589
             +    +EEAE+LRRQ  +E +R+R  EV+L    +         ++ LQA E +    E
Sbjct: 1468 RQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1524

Query: 590  EKKKQIEQ----KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 645
            E ++++ Q    +  Q+    E A+    AE ++K+ + A+K  ++E  R  +EE   + 
Sbjct: 1525 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE--RSLQEEHVAVA 1582

Query: 646  WLQQEEEERRHQELLQKKKEEEQER-----LRKAAEAKRL---AEQREQERREQERREQE 697
             L++E E R  Q+   ++  EE ER       KA EA RL   AE+  Q++   +   ++
Sbjct: 1583 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1642

Query: 698  RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
            ++E+  RE  RR +  + A ++R   ++ L+ +R+L E     RL  EQ    L  + ++
Sbjct: 1643 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1702

Query: 758  EEQQRLAERQLQEEQEKKAKEAAGASK 784
             EQQR   + L+EE  +  +EAA A++
Sbjct: 1703 GEQQR---QLLEEELARLQREAAAATQ 1726



 Score = 96.7 bits (239), Expect = 9e-20
 Identities = 150/595 (25%), Positives = 258/595 (43%), Gaps = 118/595 (19%)

Query: 296  SRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAK-QESVVRRASRRL----AKKTAEEPAAS 350
            +  + QS R S    ++   + L +++  VA+ +E   RRA ++     A++ AE     
Sbjct: 1552 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611

Query: 351  GRIICHSYLE-RLLNVEVPQKVG---SEQKEPPEEAEPVA-----AAEPEVPENNGNNSW 401
             ++  +  L  RL   EV Q+     +E ++  EEAE  A     A E  V +       
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671

Query: 402  PHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELD 461
                 ++A  T   + AA         +  A+T+Q +  R+  +     R  ++A +   
Sbjct: 1672 LEKQRQLAEGTAQQRLAAEQELI----RLRAETEQGEQQRQLLEE-ELARLQREAAAATQ 1726

Query: 462  EEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK 521
            + Q LE  EL   R++        ++     R+   T ++++  +    A     +   +
Sbjct: 1727 KRQELE-AELAKVRAEMEVLLASKARAEEESRS---TSEKSKQRL---EAEAGRFRELAE 1779

Query: 522  RNTPLRMDPKEKERQRL----ENLRRKEEAEQLRRQKV----EEDKRRRLEEVKLKREE- 572
                LR   +E +RQR     +  R++ EAE++  +K+    E  + +   E+ LK +E 
Sbjct: 1780 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1839

Query: 573  ---RLRKVLQ----ARERVEQMKEEKKKQIEQKFAQI----DEKTEKAK----------- 610
               RLR++ +     R R+E+   + K  IE++ AQ+    D + E+ K           
Sbjct: 1840 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1899

Query: 611  ---EERLAEEKAKKKAAAKKME--------------EVEARRKQEEEARRLRWLQQEEEE 653
               EE LA + + +KAAA K E               + ++ + E EA R R L  EEE 
Sbjct: 1900 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1959

Query: 654  RRHQ--ELLQKK--KEEEQERLRKAA------------EAKRLAEQREQERREQ------ 691
            RR +  E +QK    EEE  R RKAA            EA+RL E+ EQE   Q      
Sbjct: 1960 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2019

Query: 692  -----------------ERREQERREQERREQERREQERQLAEQERR----REQERLQAE 730
                             +++EQE ++  ++EQ   +Q R  AE  RR     E+ R+QAE
Sbjct: 2020 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2079

Query: 731  RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKA 785
            RE  +  + +  + E+L++  EE+ +   Q + A  +L++E E++A   A A +A
Sbjct: 2080 REAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2133



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 75/243 (30%), Positives = 127/243 (52%), Gaps = 22/243 (9%)

Query: 539  ENLRRKEEAE---QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQI 595
            + LR KE+AE     +RQ   E++RRR E      EER++K L A E   + ++   +++
Sbjct: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREA-----EERVQKSLAAEEEAARQRKAALEEV 1989

Query: 596  EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 655
            E+  A+++E   +   ER  +E A++   A   +E   +R Q EE      +QQ+E+E  
Sbjct: 1990 ERLKAKVEEA--RRLRERAEQESARQLQLA---QEAAQKRLQAEEKAHAFAVQQKEQEL- 2043

Query: 656  HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ----ERREQERREQ 711
             Q+ LQ+++    +   +A  A+R AE+ E+ R + ER   + R Q    ER +Q   EQ
Sbjct: 2044 -QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2102

Query: 712  ERQLAEQERRREQERLQAERELQER---EKALRLQKEQLQRELEEKKKKEEQQRLAERQL 768
             +  A+ +   E+ R +AE+E   R   E+A   QK+    E+E+ KK  EQ    + Q+
Sbjct: 2103 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2162

Query: 769  QEE 771
            ++E
Sbjct: 2163 EQE 2165



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 87/327 (26%), Positives = 161/327 (49%), Gaps = 29/327 (8%)

Query: 531  KEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRL---EEVKLKREERLRKVLQARERVE 585
            + KE+  LE  R+++ A  E+ RR++ EE  ++ L   EE   +R+  L +V + + +VE
Sbjct: 1938 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1997

Query: 586  QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE------ 639
            + +  +++  ++   Q+    E A++   AEEKA   A  +K +E++   +QE+      
Sbjct: 1998 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2057

Query: 640  --EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 697
              EA   R   +E EE R    +Q ++E  Q R R+  EA+RL +Q  +E+ +   + Q 
Sbjct: 2058 RGEAEAARRAAEEAEEAR----VQAEREAAQSR-RQVEEAERL-KQSAEEQAQARAQAQA 2111

Query: 698  RREQERREQERREQERQLAEQERRREQERLQAERELQER--EKALRLQKEQLQRELEEKK 755
              E+ R+E E+    R  AEQ   R+++   AE E  ++  E+ LR QK Q+++EL   +
Sbjct: 2112 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTTLR 2170

Query: 756  KKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINP 815
             + E+    +  L EE ++   EA  A++  +    V+    +      +  +   +I  
Sbjct: 2171 LQLEETDHQKNLLDEELQRLKAEATEAARQRS---QVEEELFSVRVQMEELSKLKARIEA 2227

Query: 816  DNYGMDLNSDDST----DDEAHPRKPI 838
            +N  + L   D+T     +EA   K +
Sbjct: 2228 ENRALILRDKDNTQRFLQEEAEKMKQV 2254



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 77/277 (27%), Positives = 135/277 (48%), Gaps = 18/277 (6%)

Query: 513  RSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 572
            R + ++  +       + KE +++  E + R+EEA        ++ KR   EE++  R+ 
Sbjct: 1351 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV----DAQQQKRSIQEELQQLRQS 1406

Query: 573  RLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVE 632
               ++ QA+ R  +  E  + +IE++   +  + E  + +R   E  + +A   + EE E
Sbjct: 1407 SEAEI-QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-GELQALRARAEEAE 1464

Query: 633  A--RRKQEEEARRLRWLQQEEEERRHQ---ELLQKKKEE-----EQERLRKAAEAKRLAE 682
            A  R+ Q EEA RLR   Q+E +R+ Q   EL  + K E     E++R  +A E  RL  
Sbjct: 1465 AQKRQAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1523

Query: 683  QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRL 742
            +  + R  Q   E+ R+ Q   E  +R  E +L  +     ++  Q ER LQE   A+  
Sbjct: 1524 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1583

Query: 743  QKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
             +E+ +R  +++ + E  +  AER+L E  + KA EA
Sbjct: 1584 LREEAERRAQQQAEAERAREEAEREL-ERWQLKANEA 1619



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 138/560 (24%), Positives = 235/560 (41%), Gaps = 117/560 (20%)

Query: 316  QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
            Q L Q+ S++ +       A+RR A++  E    + R    S   R    E  +   S +
Sbjct: 2045 QTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQS---RRQVEEAERLKQSAE 2100

Query: 376  KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTD 435
            ++    A+  AAAE    E          + E A      + A    +   A  ++ K  
Sbjct: 2101 EQAQARAQAQAAAEKLRKEA---------EQEAARRAQAEQAALRQKQAADAEMEKHKKF 2151

Query: 436  QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF 495
                 R+  Q  +   + +  + E D +++L DEELQ  +++   +    S+V   L + 
Sbjct: 2152 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2211

Query: 496  LHTVQRNQMLMTPTSAPRSVMKSFIKRNTP-LRMDPKEKERQRLENLRR----KEEAEQL 550
               ++    L     A    +    K NT     +  EK +Q  E   R     +EA +L
Sbjct: 2212 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2271

Query: 551  RRQKVEED--KRRRLEEVKLKREERLRKVLQAR------ERVEQMKE----------EKK 592
            R Q  EED  ++R L E  LK  E+++ V +A       E ++Q KE          E K
Sbjct: 2272 R-QLAEEDLAQQRALAEKMLK--EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2328

Query: 593  KQIEQKFAQIDE---KTEKAKEERLAEEKAKKKAAAKKMEEVE-ARRKQEEEARRLRWLQ 648
            +Q+ Q+ A+  +   +T +A+ +R  E  A+ +    ++ E+  A+ + EE+A+R R   
Sbjct: 2329 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2388

Query: 649  QEEEERRHQ---------------ELLQKKKEEEQERLRKA-AEAKRLAEQREQERR--- 689
            +E  E+ H+               E+ +++ + + ERLR+A AE +R  E+ +QE +   
Sbjct: 2389 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2448

Query: 690  ---------------------------------------EQERREQER-------REQER 703
                                                   EQE+ + E+       + Q+ 
Sbjct: 2449 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2508

Query: 704  REQERREQERQLAEQERRR------EQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
            RE+++R+Q++   EQER+R      E  R Q E E   R K   LQ+ + QR  +E+   
Sbjct: 2509 REEQQRQQQQM--EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2566

Query: 758  EEQQRLAER-QLQEEQEKKA 776
            EE QRL E+ QL EEQ + A
Sbjct: 2567 EENQRLREQLQLLEEQHRAA 2586



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 98/403 (24%), Positives = 185/403 (45%), Gaps = 53/403 (13%)

Query: 445  QSARRKRSYKQAVSELDEEQHLED--------EELQPPRSKTPSSPCPASKVVRPLRTFL 496
            Q ARR++   QA+   D +   E         EE++    K       A + +  ++ + 
Sbjct: 1202 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1261

Query: 497  HTVQRNQMLMTPTSAP------RSVMKSFIKRNTPLRMDPKEKERQRL-------ENLRR 543
              +   +  + P ++P      +S  +S I+    LR    E             E LRR
Sbjct: 1262 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1321

Query: 544  KEEAEQLRRQKVEEDKRRRLE-EVKLKREERLRKV-LQARERVEQMKEEKKKQIEQKFAQ 601
             EE E+L  Q+  E++ R  E E  L+++ +L +   QA+ + E+  +E +++++++  +
Sbjct: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381

Query: 602  IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQ 661
             +E    A++++ + ++  ++       E++A+ +Q E A R R L+ EEE R     + 
Sbjct: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIR-----VV 1435

Query: 662  KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 721
            + + E  ER R  AE     E +    R +E   Q+R+ QE  E+ RR    Q+ ++ +R
Sbjct: 1436 RLQLEATERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRR----QVQDESQR 1487

Query: 722  REQ------ERLQAERE-LQEREKA------LRLQKEQLQREL---EEKKKKEEQQRLAE 765
            + Q       R++AE E  +E+++A      LRLQ E+ +R L   E ++ ++ Q  L  
Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1547

Query: 766  RQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHR 808
             Q   E E ++K A+ A K   +   +Q       Q+  +  R
Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER 1590



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 120/544 (22%), Positives = 218/544 (40%), Gaps = 79/544 (14%)

Query: 299  DSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSY 358
            +SQ  R + +  +S   +V A+  +   KQ ++      RL  + AE      R +  + 
Sbjct: 1484 ESQRKRQAEVELAS---RVKAEAEAAREKQRALQALEELRLQAEEAE------RRLRQAE 1534

Query: 359  LERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
            +ER   V+V  +      E   +++  + AE          S       +A      +  
Sbjct: 1535 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR 1591

Query: 419  ASSPETPSAGQQEA---------KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
            A         ++EA         K ++A   R   +   +++S  QA +E  +E   E E
Sbjct: 1592 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---EAE 1648

Query: 470  ELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMD 529
                 R K         + VR        +++ + L   T+  R   +  + R   LR +
Sbjct: 1649 REARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR---LRAE 1699

Query: 530  PKEKERQR------LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER 583
             ++ E+QR      L  L+R+  A   +RQ++E +    L +V+ + E  L    +A E 
Sbjct: 1700 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----LAKVRAEMEVLLASKARAEEE 1755

Query: 584  VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE--- 640
                 E+ K+++E +  +  E  E+A   R   E+AK++   +  EE  AR++ E E   
Sbjct: 1756 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--QLAEEDAARQRAEAERVL 1813

Query: 641  ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 700
            A +L  + +    +   E+  K+KE E ERLR+ AE +    +R +E+  Q + + E R 
Sbjct: 1814 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1873

Query: 701  QERREQERREQERQLA------EQERRREQE-------------------------RLQA 729
             + R+    E ERQ         Q R+ E+E                         R  A
Sbjct: 1874 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1933

Query: 730  ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVT 789
            E  L+ +E+A      Q Q   EE++++ E +   ++ L  E+E   +  A   +   + 
Sbjct: 1934 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 1993

Query: 790  VDVQ 793
              V+
Sbjct: 1994 AKVE 1997



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 119/525 (22%), Positives = 224/525 (42%), Gaps = 92/525 (17%)

Query: 319  AQKYSLVAKQESVVRRASRRLAKK-TAEEPAASGRIICHSYLERLL-------------- 363
            A++  L A++E   R A  R+ K   AEE AA  R      +ERL               
Sbjct: 1948 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2007

Query: 364  -----NVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
                  +++ Q+   ++ +  E+A   A  + E        +     + +       + A
Sbjct: 2008 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAA 2064

Query: 419  ASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKT 478
              + E     + +A+ + A   R+  ++ R K+S ++      + Q   ++  +    + 
Sbjct: 2065 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124

Query: 479  PSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRL 538
                      +R  +     +++++     T   ++ ++  +   T LR+  +E + Q+ 
Sbjct: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL---TTLRLQLEETDHQKN 2181

Query: 539  ---ENLRR-KEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ 594
               E L+R K EA +  RQ+ + ++      V+++   +L+  ++A  R   +++   K 
Sbjct: 2182 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---KD 2238

Query: 595  IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEER 654
              Q+F Q  E+ EK K+  +AEE A+   AA             +EA RLR L +E+  +
Sbjct: 2239 NTQRFLQ--EEAEKMKQ--VAEEAARLSVAA-------------QEAARLRQLAEEDLAQ 2281

Query: 655  RH---QELLQKKKEEEQERLRKAAEAKRLAEQR----EQERREQERREQERRE------- 700
            +    +++L++K +  QE  R  AEA+ L +Q+    EQ RR QE +EQ  ++       
Sbjct: 2282 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2341

Query: 701  -QERREQERREQERQLAEQER-------------RREQE----RLQAER--------ELQ 734
             Q   E ER+ Q    AE ER             R E++    R QAE         EL 
Sbjct: 2342 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2401

Query: 735  EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
             +EK   +Q  ++QR+  +   +  ++ +AE  L+ E+EK  +EA
Sbjct: 2402 TQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKEKLQQEA 2444



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 70/275 (25%), Positives = 129/275 (46%), Gaps = 16/275 (5%)

Query: 532  EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKL--KREERLRKVLQARERVEQMKE 589
            E ERQR   +  + E  +LR  ++   + R  E+ +   K+ E + + L   E   Q K 
Sbjct: 2347 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2406

Query: 590  EKKKQIEQKFAQIDEKTEKAKEE--RLAEEKAKKKAAAK--KMEEVEARRKQEEEARRLR 645
               + +E +  Q D   E+ +E    L  EK K +  AK  +++  E +  Q+E+  +  
Sbjct: 2407 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2466

Query: 646  WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR- 704
               Q+        LLQ+++  EQE+ +     +    + +Q R EQ+R++Q+  ++ +R 
Sbjct: 2467 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2526

Query: 705  ---EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 761
                +E R ++ +  E  RR+++E  Q E++ +++E+ L    E+ QR  E+ +  EEQ 
Sbjct: 2527 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL---AEENQRLREQLQLLEEQH 2583

Query: 762  RLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPA 796
            R A   L   +E  A + A      N    +  PA
Sbjct: 2584 RAA---LAHSEEVTASQVAATKTLPNGRDALDGPA 2615



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 80/345 (23%), Positives = 153/345 (44%), Gaps = 46/345 (13%)

Query: 433  KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPL 492
            +T +A+  R+   SA  +R  K  V+E+   Q   +E+ Q  R +       A ++   L
Sbjct: 2344 RTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEEDAQRFRKQ-------AEEIGEKL 2395

Query: 493  -RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLR 551
             RT L T ++  ++ T                  ++    + + +RL     + E E+ +
Sbjct: 2396 HRTELATQEKVTLVQT----------------LEIQRQQSDHDAERLREAIAELEREKEK 2439

Query: 552  RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 611
             Q+  +  + + EE++  ++E+L   LQ  + ++Q    +K  + Q+   I++  EKAK 
Sbjct: 2440 LQQEAKLLQLKSEEMQTVQQEQL---LQETQALQQSFLSEKDSLLQRERFIEQ--EKAKL 2494

Query: 612  ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL 671
            E+L +++  K   A+++ E + R++Q+ E  R R +   EE RR Q   ++    +QE L
Sbjct: 2495 EQLFQDEVAK---AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2551

Query: 672  RKAAEAKRLAEQREQERREQERREQERREQERRE-QERREQERQLAEQERRREQERLQAE 730
                      +Q EQ+RR+QE    E  ++ R + Q   EQ R            ++ A 
Sbjct: 2552 ----------QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2601

Query: 731  RELQEREKAL--RLQKEQLQRELEEKKKKEEQQRLAERQLQEEQE 773
            + L     AL     + + +   +  ++K   QRL E  +   +E
Sbjct: 2602 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2646



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 61/278 (21%), Positives = 128/278 (46%), Gaps = 35/278 (12%)

Query: 541  LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR---KVLQARERVEQMKEEKKKQIEQ 597
            +R  + AE++ R   E+ K  +     L   E  +   K L+A+   +Q   +  +   +
Sbjct: 1073 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1132

Query: 598  KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA--------RRKQEEEARRLRWLQQ 649
               ++ E+ ++   ER  E +  ++  A+ +E  +A        +R+ E+  R+LR+ + 
Sbjct: 1133 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR- 1191

Query: 650  EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR--EQERREQERREQERREQE 707
            E  +     L   ++ +EQ +    A+++ + EQ  QE+   E+  R  E+ E+ +R  +
Sbjct: 1192 ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1251

Query: 708  R-----REQERQLAEQERRRE-------QERLQ--AERELQE-------REKALRLQKEQ 746
            +     ++ E QL   + + E       + ++Q  +E  +QE         +   L  + 
Sbjct: 1252 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1311

Query: 747  LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 784
            ++   E  ++ EE++RLAE+Q  EE+E+ A+  A   K
Sbjct: 1312 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1349


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  102 bits (253), Expect = 2e-21
 Identities = 100/387 (25%), Positives = 182/387 (47%), Gaps = 34/387 (8%)

Query: 418  AASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK 477
            A +  +  +  ++EAK  Q    R   +  RR+ +   AV    +++ +++E  Q  +S 
Sbjct: 1362 AEAHAQAKAQAEREAKELQQ---RMQEEVVRREEA---AVDAQQQKRSIQEELQQLRQSS 1415

Query: 478  TPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQR 537
                   A +     R+ L   +  +++     A              LR   +E E Q+
Sbjct: 1416 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1475

Query: 538  LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERL--------RKVLQARERVEQMKE 589
             +    +EEAE+LRRQ  +E +R+R  EV+L    +         ++ LQA E +    E
Sbjct: 1476 RQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1532

Query: 590  EKKKQIEQ----KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 645
            E ++++ Q    +  Q+    E A+    AE ++K+ + A+K  ++E  R  +EE   + 
Sbjct: 1533 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE--RSLQEEHVAVA 1590

Query: 646  WLQQEEEERRHQELLQKKKEEEQER-----LRKAAEAKRL---AEQREQERREQERREQE 697
             L++E E R  Q+   ++  EE ER       KA EA RL   AE+  Q++   +   ++
Sbjct: 1591 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1650

Query: 698  RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
            ++E+  RE  RR +  + A ++R   ++ L+ +R+L E     RL  EQ    L  + ++
Sbjct: 1651 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1710

Query: 758  EEQQRLAERQLQEEQEKKAKEAAGASK 784
             EQQR   + L+EE  +  +EAA A++
Sbjct: 1711 GEQQR---QLLEEELARLQREAAAATQ 1734



 Score = 96.7 bits (239), Expect = 9e-20
 Identities = 150/595 (25%), Positives = 258/595 (43%), Gaps = 118/595 (19%)

Query: 296  SRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAK-QESVVRRASRRL----AKKTAEEPAAS 350
            +  + QS R S    ++   + L +++  VA+ +E   RRA ++     A++ AE     
Sbjct: 1560 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619

Query: 351  GRIICHSYLE-RLLNVEVPQKVG---SEQKEPPEEAEPVA-----AAEPEVPENNGNNSW 401
             ++  +  L  RL   EV Q+     +E ++  EEAE  A     A E  V +       
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1679

Query: 402  PHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELD 461
                 ++A  T   + AA         +  A+T+Q +  R+  +     R  ++A +   
Sbjct: 1680 LEKQRQLAEGTAQQRLAAEQELI----RLRAETEQGEQQRQLLEE-ELARLQREAAAATQ 1734

Query: 462  EEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK 521
            + Q LE  EL   R++        ++     R+   T ++++  +    A     +   +
Sbjct: 1735 KRQELE-AELAKVRAEMEVLLASKARAEEESRS---TSEKSKQRL---EAEAGRFRELAE 1787

Query: 522  RNTPLRMDPKEKERQRL----ENLRRKEEAEQLRRQKV----EEDKRRRLEEVKLKREE- 572
                LR   +E +RQR     +  R++ EAE++  +K+    E  + +   E+ LK +E 
Sbjct: 1788 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1847

Query: 573  ---RLRKVLQ----ARERVEQMKEEKKKQIEQKFAQI----DEKTEKAK----------- 610
               RLR++ +     R R+E+   + K  IE++ AQ+    D + E+ K           
Sbjct: 1848 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1907

Query: 611  ---EERLAEEKAKKKAAAKKME--------------EVEARRKQEEEARRLRWLQQEEEE 653
               EE LA + + +KAAA K E               + ++ + E EA R R L  EEE 
Sbjct: 1908 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1967

Query: 654  RRHQ--ELLQKK--KEEEQERLRKAA------------EAKRLAEQREQERREQ------ 691
            RR +  E +QK    EEE  R RKAA            EA+RL E+ EQE   Q      
Sbjct: 1968 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2027

Query: 692  -----------------ERREQERREQERREQERREQERQLAEQERR----REQERLQAE 730
                             +++EQE ++  ++EQ   +Q R  AE  RR     E+ R+QAE
Sbjct: 2028 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2087

Query: 731  RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKA 785
            RE  +  + +  + E+L++  EE+ +   Q + A  +L++E E++A   A A +A
Sbjct: 2088 REAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2141



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 75/243 (30%), Positives = 127/243 (52%), Gaps = 22/243 (9%)

Query: 539  ENLRRKEEAE---QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQI 595
            + LR KE+AE     +RQ   E++RRR E      EER++K L A E   + ++   +++
Sbjct: 1943 DTLRSKEQAELEAARQRQLAAEEERRRREA-----EERVQKSLAAEEEAARQRKAALEEV 1997

Query: 596  EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 655
            E+  A+++E   +   ER  +E A++   A   +E   +R Q EE      +QQ+E+E  
Sbjct: 1998 ERLKAKVEEA--RRLRERAEQESARQLQLA---QEAAQKRLQAEEKAHAFAVQQKEQEL- 2051

Query: 656  HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ----ERREQERREQ 711
             Q+ LQ+++    +   +A  A+R AE+ E+ R + ER   + R Q    ER +Q   EQ
Sbjct: 2052 -QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2110

Query: 712  ERQLAEQERRREQERLQAERELQER---EKALRLQKEQLQRELEEKKKKEEQQRLAERQL 768
             +  A+ +   E+ R +AE+E   R   E+A   QK+    E+E+ KK  EQ    + Q+
Sbjct: 2111 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2170

Query: 769  QEE 771
            ++E
Sbjct: 2171 EQE 2173



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 87/327 (26%), Positives = 161/327 (49%), Gaps = 29/327 (8%)

Query: 531  KEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRL---EEVKLKREERLRKVLQARERVE 585
            + KE+  LE  R+++ A  E+ RR++ EE  ++ L   EE   +R+  L +V + + +VE
Sbjct: 1946 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2005

Query: 586  QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE------ 639
            + +  +++  ++   Q+    E A++   AEEKA   A  +K +E++   +QE+      
Sbjct: 2006 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2065

Query: 640  --EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 697
              EA   R   +E EE R    +Q ++E  Q R R+  EA+RL +Q  +E+ +   + Q 
Sbjct: 2066 RGEAEAARRAAEEAEEAR----VQAEREAAQSR-RQVEEAERL-KQSAEEQAQARAQAQA 2119

Query: 698  RREQERREQERREQERQLAEQERRREQERLQAERELQER--EKALRLQKEQLQRELEEKK 755
              E+ R+E E+    R  AEQ   R+++   AE E  ++  E+ LR QK Q+++EL   +
Sbjct: 2120 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTTLR 2178

Query: 756  KKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINP 815
             + E+    +  L EE ++   EA  A++  +    V+    +      +  +   +I  
Sbjct: 2179 LQLEETDHQKNLLDEELQRLKAEATEAARQRS---QVEEELFSVRVQMEELSKLKARIEA 2235

Query: 816  DNYGMDLNSDDST----DDEAHPRKPI 838
            +N  + L   D+T     +EA   K +
Sbjct: 2236 ENRALILRDKDNTQRFLQEEAEKMKQV 2262



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 77/277 (27%), Positives = 135/277 (48%), Gaps = 18/277 (6%)

Query: 513  RSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 572
            R + ++  +       + KE +++  E + R+EEA        ++ KR   EE++  R+ 
Sbjct: 1359 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV----DAQQQKRSIQEELQQLRQS 1414

Query: 573  RLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVE 632
               ++ QA+ R  +  E  + +IE++   +  + E  + +R   E  + +A   + EE E
Sbjct: 1415 SEAEI-QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-GELQALRARAEEAE 1472

Query: 633  A--RRKQEEEARRLRWLQQEEEERRHQ---ELLQKKKEE-----EQERLRKAAEAKRLAE 682
            A  R+ Q EEA RLR   Q+E +R+ Q   EL  + K E     E++R  +A E  RL  
Sbjct: 1473 AQKRQAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1531

Query: 683  QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRL 742
            +  + R  Q   E+ R+ Q   E  +R  E +L  +     ++  Q ER LQE   A+  
Sbjct: 1532 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1591

Query: 743  QKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
             +E+ +R  +++ + E  +  AER+L E  + KA EA
Sbjct: 1592 LREEAERRAQQQAEAERAREEAEREL-ERWQLKANEA 1627



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 138/560 (24%), Positives = 235/560 (41%), Gaps = 117/560 (20%)

Query: 316  QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
            Q L Q+ S++ +       A+RR A++  E    + R    S   R    E  +   S +
Sbjct: 2053 QTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQS---RRQVEEAERLKQSAE 2108

Query: 376  KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTD 435
            ++    A+  AAAE    E          + E A      + A    +   A  ++ K  
Sbjct: 2109 EQAQARAQAQAAAEKLRKEA---------EQEAARRAQAEQAALRQKQAADAEMEKHKKF 2159

Query: 436  QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF 495
                 R+  Q  +   + +  + E D +++L DEELQ  +++   +    S+V   L + 
Sbjct: 2160 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2219

Query: 496  LHTVQRNQMLMTPTSAPRSVMKSFIKRNTP-LRMDPKEKERQRLENLRR----KEEAEQL 550
               ++    L     A    +    K NT     +  EK +Q  E   R     +EA +L
Sbjct: 2220 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2279

Query: 551  RRQKVEED--KRRRLEEVKLKREERLRKVLQAR------ERVEQMKE----------EKK 592
            R Q  EED  ++R L E  LK  E+++ V +A       E ++Q KE          E K
Sbjct: 2280 R-QLAEEDLAQQRALAEKMLK--EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2336

Query: 593  KQIEQKFAQIDE---KTEKAKEERLAEEKAKKKAAAKKMEEVE-ARRKQEEEARRLRWLQ 648
            +Q+ Q+ A+  +   +T +A+ +R  E  A+ +    ++ E+  A+ + EE+A+R R   
Sbjct: 2337 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2396

Query: 649  QEEEERRHQ---------------ELLQKKKEEEQERLRKA-AEAKRLAEQREQERR--- 689
            +E  E+ H+               E+ +++ + + ERLR+A AE +R  E+ +QE +   
Sbjct: 2397 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2456

Query: 690  ---------------------------------------EQERREQER-------REQER 703
                                                   EQE+ + E+       + Q+ 
Sbjct: 2457 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2516

Query: 704  REQERREQERQLAEQERRR------EQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
            RE+++R+Q++   EQER+R      E  R Q E E   R K   LQ+ + QR  +E+   
Sbjct: 2517 REEQQRQQQQM--EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2574

Query: 758  EEQQRLAER-QLQEEQEKKA 776
            EE QRL E+ QL EEQ + A
Sbjct: 2575 EENQRLREQLQLLEEQHRAA 2594



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 98/403 (24%), Positives = 185/403 (45%), Gaps = 53/403 (13%)

Query: 445  QSARRKRSYKQAVSELDEEQHLED--------EELQPPRSKTPSSPCPASKVVRPLRTFL 496
            Q ARR++   QA+   D +   E         EE++    K       A + +  ++ + 
Sbjct: 1210 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1269

Query: 497  HTVQRNQMLMTPTSAP------RSVMKSFIKRNTPLRMDPKEKERQRL-------ENLRR 543
              +   +  + P ++P      +S  +S I+    LR    E             E LRR
Sbjct: 1270 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1329

Query: 544  KEEAEQLRRQKVEEDKRRRLE-EVKLKREERLRKV-LQARERVEQMKEEKKKQIEQKFAQ 601
             EE E+L  Q+  E++ R  E E  L+++ +L +   QA+ + E+  +E +++++++  +
Sbjct: 1330 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1389

Query: 602  IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQ 661
             +E    A++++ + ++  ++       E++A+ +Q E A R R L+ EEE R     + 
Sbjct: 1390 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIR-----VV 1443

Query: 662  KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 721
            + + E  ER R  AE     E +    R +E   Q+R+ QE  E+ RR    Q+ ++ +R
Sbjct: 1444 RLQLEATERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRR----QVQDESQR 1495

Query: 722  REQ------ERLQAERE-LQEREKA------LRLQKEQLQREL---EEKKKKEEQQRLAE 765
            + Q       R++AE E  +E+++A      LRLQ E+ +R L   E ++ ++ Q  L  
Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1555

Query: 766  RQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHR 808
             Q   E E ++K A+ A K   +   +Q       Q+  +  R
Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER 1598



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 120/544 (22%), Positives = 218/544 (40%), Gaps = 79/544 (14%)

Query: 299  DSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSY 358
            +SQ  R + +  +S   +V A+  +   KQ ++      RL  + AE      R +  + 
Sbjct: 1492 ESQRKRQAEVELAS---RVKAEAEAAREKQRALQALEELRLQAEEAE------RRLRQAE 1542

Query: 359  LERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
            +ER   V+V  +      E   +++  + AE          S       +A      +  
Sbjct: 1543 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR 1599

Query: 419  ASSPETPSAGQQEA---------KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
            A         ++EA         K ++A   R   +   +++S  QA +E  +E   E E
Sbjct: 1600 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---EAE 1656

Query: 470  ELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMD 529
                 R K         + VR        +++ + L   T+  R   +  + R   LR +
Sbjct: 1657 REARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR---LRAE 1707

Query: 530  PKEKERQR------LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER 583
             ++ E+QR      L  L+R+  A   +RQ++E +    L +V+ + E  L    +A E 
Sbjct: 1708 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----LAKVRAEMEVLLASKARAEEE 1763

Query: 584  VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE--- 640
                 E+ K+++E +  +  E  E+A   R   E+AK++   +  EE  AR++ E E   
Sbjct: 1764 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--QLAEEDAARQRAEAERVL 1821

Query: 641  ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 700
            A +L  + +    +   E+  K+KE E ERLR+ AE +    +R +E+  Q + + E R 
Sbjct: 1822 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1881

Query: 701  QERREQERREQERQLA------EQERRREQE-------------------------RLQA 729
             + R+    E ERQ         Q R+ E+E                         R  A
Sbjct: 1882 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1941

Query: 730  ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVT 789
            E  L+ +E+A      Q Q   EE++++ E +   ++ L  E+E   +  A   +   + 
Sbjct: 1942 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2001

Query: 790  VDVQ 793
              V+
Sbjct: 2002 AKVE 2005



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 119/525 (22%), Positives = 224/525 (42%), Gaps = 92/525 (17%)

Query: 319  AQKYSLVAKQESVVRRASRRLAKK-TAEEPAASGRIICHSYLERLL-------------- 363
            A++  L A++E   R A  R+ K   AEE AA  R      +ERL               
Sbjct: 1956 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2015

Query: 364  -----NVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
                  +++ Q+   ++ +  E+A   A  + E        +     + +       + A
Sbjct: 2016 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAA 2072

Query: 419  ASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKT 478
              + E     + +A+ + A   R+  ++ R K+S ++      + Q   ++  +    + 
Sbjct: 2073 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2132

Query: 479  PSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRL 538
                      +R  +     +++++     T   ++ ++  +   T LR+  +E + Q+ 
Sbjct: 2133 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL---TTLRLQLEETDHQKN 2189

Query: 539  ---ENLRR-KEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ 594
               E L+R K EA +  RQ+ + ++      V+++   +L+  ++A  R   +++   K 
Sbjct: 2190 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---KD 2246

Query: 595  IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEER 654
              Q+F Q  E+ EK K+  +AEE A+   AA             +EA RLR L +E+  +
Sbjct: 2247 NTQRFLQ--EEAEKMKQ--VAEEAARLSVAA-------------QEAARLRQLAEEDLAQ 2289

Query: 655  RH---QELLQKKKEEEQERLRKAAEAKRLAEQR----EQERREQERREQERRE------- 700
            +    +++L++K +  QE  R  AEA+ L +Q+    EQ RR QE +EQ  ++       
Sbjct: 2290 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2349

Query: 701  -QERREQERREQERQLAEQER-------------RREQE----RLQAER--------ELQ 734
             Q   E ER+ Q    AE ER             R E++    R QAE         EL 
Sbjct: 2350 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2409

Query: 735  EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
             +EK   +Q  ++QR+  +   +  ++ +AE  L+ E+EK  +EA
Sbjct: 2410 TQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKEKLQQEA 2452



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 70/275 (25%), Positives = 129/275 (46%), Gaps = 16/275 (5%)

Query: 532  EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKL--KREERLRKVLQARERVEQMKE 589
            E ERQR   +  + E  +LR  ++   + R  E+ +   K+ E + + L   E   Q K 
Sbjct: 2355 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2414

Query: 590  EKKKQIEQKFAQIDEKTEKAKEE--RLAEEKAKKKAAAK--KMEEVEARRKQEEEARRLR 645
               + +E +  Q D   E+ +E    L  EK K +  AK  +++  E +  Q+E+  +  
Sbjct: 2415 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2474

Query: 646  WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR- 704
               Q+        LLQ+++  EQE+ +     +    + +Q R EQ+R++Q+  ++ +R 
Sbjct: 2475 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2534

Query: 705  ---EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 761
                +E R ++ +  E  RR+++E  Q E++ +++E+ L    E+ QR  E+ +  EEQ 
Sbjct: 2535 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL---AEENQRLREQLQLLEEQH 2591

Query: 762  RLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPA 796
            R A   L   +E  A + A      N    +  PA
Sbjct: 2592 RAA---LAHSEEVTASQVAATKTLPNGRDALDGPA 2623



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 80/345 (23%), Positives = 153/345 (44%), Gaps = 46/345 (13%)

Query: 433  KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPL 492
            +T +A+  R+   SA  +R  K  V+E+   Q   +E+ Q  R +       A ++   L
Sbjct: 2352 RTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEEDAQRFRKQ-------AEEIGEKL 2403

Query: 493  -RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLR 551
             RT L T ++  ++ T                  ++    + + +RL     + E E+ +
Sbjct: 2404 HRTELATQEKVTLVQT----------------LEIQRQQSDHDAERLREAIAELEREKEK 2447

Query: 552  RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 611
             Q+  +  + + EE++  ++E+L   LQ  + ++Q    +K  + Q+   I++  EKAK 
Sbjct: 2448 LQQEAKLLQLKSEEMQTVQQEQL---LQETQALQQSFLSEKDSLLQRERFIEQ--EKAKL 2502

Query: 612  ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL 671
            E+L +++  K   A+++ E + R++Q+ E  R R +   EE RR Q   ++    +QE L
Sbjct: 2503 EQLFQDEVAK---AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2559

Query: 672  RKAAEAKRLAEQREQERREQERREQERREQERRE-QERREQERQLAEQERRREQERLQAE 730
                      +Q EQ+RR+QE    E  ++ R + Q   EQ R            ++ A 
Sbjct: 2560 ----------QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2609

Query: 731  RELQEREKAL--RLQKEQLQRELEEKKKKEEQQRLAERQLQEEQE 773
            + L     AL     + + +   +  ++K   QRL E  +   +E
Sbjct: 2610 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2654



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 61/278 (21%), Positives = 128/278 (46%), Gaps = 35/278 (12%)

Query: 541  LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR---KVLQARERVEQMKEEKKKQIEQ 597
            +R  + AE++ R   E+ K  +     L   E  +   K L+A+   +Q   +  +   +
Sbjct: 1081 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1140

Query: 598  KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA--------RRKQEEEARRLRWLQQ 649
               ++ E+ ++   ER  E +  ++  A+ +E  +A        +R+ E+  R+LR+ + 
Sbjct: 1141 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR- 1199

Query: 650  EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR--EQERREQERREQERREQE 707
            E  +     L   ++ +EQ +    A+++ + EQ  QE+   E+  R  E+ E+ +R  +
Sbjct: 1200 ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1259

Query: 708  R-----REQERQLAEQERRRE-------QERLQ--AERELQE-------REKALRLQKEQ 746
            +     ++ E QL   + + E       + ++Q  +E  +QE         +   L  + 
Sbjct: 1260 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1319

Query: 747  LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 784
            ++   E  ++ EE++RLAE+Q  EE+E+ A+  A   K
Sbjct: 1320 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1357


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.124    0.338 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,279,663
Number of Sequences: 37866
Number of extensions: 2382880
Number of successful extensions: 124185
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1676
Number of HSP's successfully gapped in prelim test: 1730
Number of HSP's that attempted gapping in prelim test: 18903
Number of HSP's gapped (non-prelim): 30019
length of query: 914
length of database: 18,247,518
effective HSP length: 111
effective length of query: 803
effective length of database: 14,044,392
effective search space: 11277646776
effective search space used: 11277646776
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press