Search of human proteins with 102467235

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|102467235 inner centromere protein antigens 135/155kDa
isoform 1 [Homo sapiens]
         (918 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|102467235 inner centromere protein antigens 135/155kDa isofor...  1803   0.0  
gi|102467242 inner centromere protein antigens 135/155kDa isofor...  1788   0.0  
gi|148746195 trichohyalin [Homo sapiens]                              140   5e-33
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...   131   3e-30
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...   130   4e-30
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...   128   3e-29
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...   127   4e-29
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...   127   6e-29
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...   117   4e-26
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...   117   4e-26
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...   116   8e-26
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap...   116   8e-26
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap...   116   8e-26
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi...   116   8e-26
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]           115   1e-25
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...   114   3e-25
gi|4503509 eukaryotic translation initiation factor 3, subunit 1...   112   2e-24
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]           112   2e-24
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]           111   3e-24
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m...   110   6e-24
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m...   110   6e-24
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                   110   6e-24
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                      103   7e-22
gi|134152708 arginine and glutamate rich 1 [Homo sapiens]             100   5e-21
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       100   6e-21
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       100   6e-21
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        100   6e-21
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        100   6e-21
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        100   6e-21
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        100   6e-21

>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 1803 bits (4669), Expect = 0.0
 Identities = 918/918 (100%), Positives = 918/918 (100%)

Query: 1   MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTP 60
           MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTP
Sbjct: 1   MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTP 60

Query: 61  SQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSV 120
           SQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSV
Sbjct: 61  SQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSV 120

Query: 121 LRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAE 180
           LRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAE
Sbjct: 121 LRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAE 180

Query: 181 QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATP 240
           QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATP
Sbjct: 181 QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATP 240

Query: 241 QDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDS 300
           QDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDS
Sbjct: 241 QDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDS 300

Query: 301 QSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLE 360
           QSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLE
Sbjct: 301 QSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLE 360

Query: 361 RLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAAS 420
           RLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAAS
Sbjct: 361 RLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAAS 420

Query: 421 SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS 480
           SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS
Sbjct: 421 SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS 480

Query: 481 SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQ 540
           SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQ
Sbjct: 481 SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQ 540

Query: 541 RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE 600
           RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE
Sbjct: 541 RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE 600

Query: 601 QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 660
           QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH
Sbjct: 601 QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 660

Query: 661 QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720
           QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA
Sbjct: 661 QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720

Query: 721 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 780
           EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA
Sbjct: 721 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 780

Query: 781 KEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRK 840
           KEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRK
Sbjct: 781 KEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRK 840

Query: 841 PIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSP 900
           PIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSP
Sbjct: 841 PIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSP 900

Query: 901 PLQGARVPSSLAYSLKKH 918
           PLQGARVPSSLAYSLKKH
Sbjct: 901 PLQGARVPSSLAYSLKKH 918


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 1788 bits (4631), Expect = 0.0
 Identities = 914/918 (99%), Positives = 914/918 (99%), Gaps = 4/918 (0%)

Query: 1   MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTP 60
           MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTP
Sbjct: 1   MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTP 60

Query: 61  SQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSV 120
           SQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSV
Sbjct: 61  SQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSV 120

Query: 121 LRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAE 180
           LRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAE
Sbjct: 121 LRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAE 180

Query: 181 QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATP 240
           QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATP
Sbjct: 181 QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATP 240

Query: 241 QDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDS 300
           QDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDS
Sbjct: 241 QDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDS 300

Query: 301 QSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLE 360
           QSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLE
Sbjct: 301 QSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLE 360

Query: 361 RLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAAS 420
           RLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAAS
Sbjct: 361 RLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAAS 420

Query: 421 SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS 480
           SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS
Sbjct: 421 SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS 480

Query: 481 SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQ 540
           SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPK    EKERQ
Sbjct: 481 SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPK----EKERQ 536

Query: 541 RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE 600
           RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE
Sbjct: 537 RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE 596

Query: 601 QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 660
           QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH
Sbjct: 597 QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 656

Query: 661 QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720
           QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA
Sbjct: 657 QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 716

Query: 721 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 780
           EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA
Sbjct: 717 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 776

Query: 781 KEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRK 840
           KEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRK
Sbjct: 777 KEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRK 836

Query: 841 PIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSP 900
           PIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSP
Sbjct: 837 PIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSP 896

Query: 901 PLQGARVPSSLAYSLKKH 918
           PLQGARVPSSLAYSLKKH
Sbjct: 897 PLQGARVPSSLAYSLKKH 914


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  140 bits (353), Expect = 5e-33
 Identities = 118/409 (28%), Positives = 224/409 (54%), Gaps = 59/409 (14%)

Query: 423 ETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRS-KTPSS 481
           E     +++ + +Q D  R   +  R+++ +++      EE+  E+E+LQ  +  +T   
Sbjct: 150 EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQER-----EERRAEEEQLQSCKGHETEEF 204

Query: 482 PCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVM----KSFIKRNTPLRMDPKCSFVEK 537
           P       R L       +  +         R       K + KR T LR + +    E+
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE-KLQEE 263

Query: 538 ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEV----KLKREERLRKVLQARERVEQ--- 590
           E QR   L+  EE EQLR+ + +E +R R EE     +L+RE++LR+  +   R +Q   
Sbjct: 264 EPQRQRELQ--EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321

Query: 591 --MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK-KMEEVEARRKQ----EE 643
              +E +++Q E++  Q+  + E+ +E++L  E+ +++   + + E+ E RR+Q    E+
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ 381

Query: 644 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKR---LAEQREQER----REQE 696
           + RR + L++E++ RR Q+L ++++   +++LR+  + +R   L  ++E+ER     EQE
Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441

Query: 697 RREQ--ERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKE----- 749
           RREQ  +R ++ERR+  +RE+E +  EQERR++Q  L+ ++E + RE+ L+L++E     
Sbjct: 442 RREQRLKREQEERRDWLKREEETERHEQERRKQQ--LKRDQEEERRERWLKLEEEERREQ 499

Query: 750 ------QLQRELEEK-----KKKEEQQRL-----AERQLQEEQEKKAKE 782
                 QL+RE EE+     K++EE++RL     +E+QL+ EQE++ ++
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548



 Score =  140 bits (353), Expect = 5e-33
 Identities = 114/388 (29%), Positives = 209/388 (53%), Gaps = 43/388 (11%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
           QQE + +Q +  R   Q  RR++  ++   E  E+Q L  E+ +  R +         + 
Sbjct: 317 QQEERREQQE--RREQQEERREQQLRREQEERREQQ-LRREQEEERREQQLRREQEEERR 373

Query: 489 VRPLRTFLHTVQRNQMLMTPTSAPRSVM---KSFIKRNTPLRMDPKCSFVEKERQRLENL 545
            + LR     ++R Q L       R      +  ++R   LR + +    ++ R+  E  
Sbjct: 374 EQQLRRE-QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432

Query: 546 RRKEEAEQLRRQ---KVEEDKRR----RLEEVKLKREERLRKVL---QARERVEQM---- 591
           R +++ EQ RR+   K E+++RR    R EE +   +ER ++ L   Q  ER E+     
Sbjct: 433 RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLE 492

Query: 592 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE-------- 643
           +EE+++Q E++  Q+  + E+ +E+RL  ++ +++   +   E + RR+QEE        
Sbjct: 493 EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552

Query: 644 -------EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAK--RLAEQREQERRE 694
                  + RR + L++E+EERR Q LL++++E  Q+RL++  E +  +  ++ E ER E
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQ-LLKREEERRQQRLKREQEERLEQRLKREEVERLE 611

Query: 695 QERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRE 754
           QE R ++R ++E  E+ERR+Q  +  EQE RR+Q   Q  RE QER +  RL++E+ +  
Sbjct: 612 QEERREQRLKREEPEEERRQQLLKSEEQEERRQQ---QLRREQQERREQ-RLKREEEEER 667

Query: 755 LEEKKKKEEQQRLAERQLQEEQEKKAKE 782
           LE++ K+E ++   E++L EE++++A+E
Sbjct: 668 LEQRLKREHEEERREQELAEEEQEQARE 695



 Score =  136 bits (343), Expect = 8e-32
 Identities = 117/395 (29%), Positives = 206/395 (52%), Gaps = 62/395 (15%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
           Q+E + +Q +  RE  Q  RR++  ++   +L  EQ  E  E Q  R +         + 
Sbjct: 310 QEEERREQQEERRE--QQERREQQEERREQQLRREQE-ERREQQLRREQEEE------RR 360

Query: 489 VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRK 548
            + LR      +R Q L       R      ++R   LR + +    E++ +R + LRR+
Sbjct: 361 EQQLRREQEEERREQQLRREQQLRREQQ---LRREQQLRREQQLRR-EQQLRREQQLRRE 416

Query: 549 EEA---EQLRRQKVEE------DKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQI 599
           ++    +QLRR++ EE      ++ RR + +K ++EER R  L+  E  E+ ++E++KQ 
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEER-RDWLKREEETERHEQERRKQ- 474

Query: 600 EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 659
                Q+    E+ + ER  + + +++   ++  E + RR+QEE  R  R  +QEEEER 
Sbjct: 475 -----QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER-REQRLKRQEEEERL 528

Query: 660 HQEL-----LQKKKEEEQERLRKAAEAKRLAEQREQER--REQERREQE--RREQERREQ 710
            Q L     L++++EE +E+L K  E KRL ++R ++R  REQE R  +  +RE+ERR+Q
Sbjct: 529 QQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQ 588

Query: 711 E-RREQERQLAEQERRREQERLQAER----------------------ELQEREKALRLQ 747
             +REQE +L ++ +R E ERL+ E                       E QE  +  +L+
Sbjct: 589 RLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLR 648

Query: 748 KEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
           +EQ +R  +  K++EE++RL +R  +E +E++ ++
Sbjct: 649 REQQERREQRLKREEEEERLEQRLKREHEEERREQ 683



 Score =  133 bits (335), Expect = 7e-31
 Identities = 104/365 (28%), Positives = 197/365 (53%), Gaps = 39/365 (10%)

Query: 441 REPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQ 500
           RE  Q  RR+R  +    E ++E    +  L+    K         + ++     L  ++
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282

Query: 501 RNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVE 560
           R ++        +   +  ++R   LR   +    E++ +R E   R+E+ E+ R Q++ 
Sbjct: 283 RQELRRERQEEEQQQQR--LRREQQLRRKQEEERREQQEERREQQERREQQEERREQQL- 339

Query: 561 EDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAE 620
              RR  EE   +RE++LR+  +   R +Q++ E+++  E++  Q+  + +  +E++L  
Sbjct: 340 ---RREQEE---RREQQLRREQEEERREQQLRREQEE--ERREQQLRREQQLRREQQLRR 391

Query: 621 EKAKKKAAAKKMEEVEARRKQ---EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK 677
           E+  ++    + E+   R +Q   E++ RR + L++E+EE RH++  + ++E  ++RL++
Sbjct: 392 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ--KHEQERREQRLKR 449

Query: 678 AAEAKR--LAEQREQERREQERREQERR---EQERR-------EQERREQERQLAEQERR 725
             E +R  L  + E ER EQERR+Q+ +   E+ERR       E+ERREQ+ +  +Q RR
Sbjct: 450 EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRR 509

Query: 726 REQERLQAERELQEREKAL--RLQKE-QLQRELEEKK----KKEEQQRL----AERQLQE 774
            ++ER +   + QE E+ L  RL+ E QL+RE EE++    K+EE++RL     E++L+ 
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKR 569

Query: 775 EQEKK 779
           EQE++
Sbjct: 570 EQEER 574



 Score =  129 bits (325), Expect = 1e-29
 Identities = 97/303 (32%), Positives = 171/303 (56%), Gaps = 42/303 (13%)

Query: 517 KSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 576
           + F  R+  L  +P     +K +++   L   EE  + + +  + D++RR EE+  +R+E
Sbjct: 120 RRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQE 179

Query: 577 -RLRKVLQARE--------------------RVEQMKEEKKKQIEQKFAQIDEKTEKAKE 615
            + R+  +A E                    R  ++ E ++K  E+K  Q  E+ ++  +
Sbjct: 180 WQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQ 239

Query: 616 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR---HQELLQKKKEEE- 671
           E   +E  K++   +K EE    + QEEE +R R LQ+EEE+ R    QEL ++++EEE 
Sbjct: 240 EEEEKEWRKRETVLRKEEE----KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQ 295

Query: 672 -QERLRKAAEAKRLAEQREQERREQERREQERREQ--ERREQERREQERQLAEQERRREQ 728
            Q+RLR+  + +R  E+  +E++E+ R +QERREQ  ERREQ+ R ++ +  EQ+ RREQ
Sbjct: 296 QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQ 355

Query: 729 E------RLQAERELQEREKALRLQKEQLQRELE---EKKKKEEQQRLAERQLQEEQEKK 779
           E      +L+ E+E + RE+ LR +++QL+RE +   E++ + EQQ   E+QL+ EQ+ +
Sbjct: 356 EEERREQQLRREQEEERREQQLR-REQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 414

Query: 780 AKE 782
            ++
Sbjct: 415 REQ 417



 Score =  127 bits (319), Expect = 5e-29
 Identities = 109/394 (27%), Positives = 197/394 (50%), Gaps = 41/394 (10%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDE--EQHLEDEELQPPRSKTPSSPCPAS 486
           Q+E +  +     E  +  +R RS +Q   E +E  EQ L+ EE +    +         
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE 570

Query: 487 KVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDP------KCSFVEKERQ 540
           +  R  +      +R Q  +      R  ++  +KR    R++       +    E E +
Sbjct: 571 QEERRDQLLKREEERRQQRLKREQEER--LEQRLKREEVERLEQEERREQRLKREEPEEE 628

Query: 541 RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE-------RLRKVLQARERVEQMKE 593
           R + L + EE E+ R+Q++  +++ R E+ +LKREE       RL++  +   R +++ E
Sbjct: 629 RRQQLLKSEEQEERRQQQLRREQQERREQ-RLKREEEEERLEQRLKREHEEERREQELAE 687

Query: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR----LR 649
           E+++Q  ++      K +   E      ++K  +  +K E    R++QEE+ RR    L+
Sbjct: 688 EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ 747

Query: 650 W-------LQQEEEERRHQELLQKKKEEEQERLRKAAEAK-RLAEQREQERREQERREQE 701
           W        QQ+EEE+R     Q + EE+ ER R+   A+  L EQRE++ R +ER+++E
Sbjct: 748 WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQRE 807

Query: 702 RR---EQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQ--LQRELE 756
           +R   E+E +EQ RR++      +ER +E + L+ E +LQ RE+A +LQ+E+  LQ + E
Sbjct: 808 QRFLPEEEEKEQRRRQR------REREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE 861

Query: 757 EKKKKEEQQRLAERQLQEEQEKKAKEAAGASKAL 790
            ++ +E+++    R   EE+ K+ +    A  AL
Sbjct: 862 RRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL 895



 Score =  127 bits (318), Expect = 6e-29
 Identities = 101/357 (28%), Positives = 193/357 (54%), Gaps = 52/357 (14%)

Query: 429  QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
            Q+  + +Q     E  Q  RR+   +Q   E D +   EDE+L   R +           
Sbjct: 1586 QKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFR-EDEQLLQEREEQQ--------- 1635

Query: 489  VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRK 548
                   LH  +R++  +      R       +R   LR D    F E+E+     L ++
Sbjct: 1636 -------LHRQERDRKFLEEEPQLRRQ-----EREQQLRHDRDRKFREEEQ-----LLQE 1678

Query: 549  EEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDE 608
             E +QLRRQ  E D++ R EE +L+R+ER RK LQ  +++      +++++E+KF + ++
Sbjct: 1679 GEEQQLRRQ--ERDRKFREEEQQLRRQERERKFLQEEQQL------RRQELERKFREEEQ 1730

Query: 609  KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK 668
              ++ ++E+L  ++  +K     +EE + R ++EE+      L+++E +R+ +E  Q ++
Sbjct: 1731 LRQETEQEQLRRQERYRKI----LEEEQLRPEREEQQ-----LRRQERDRKFREEEQLRQ 1781

Query: 669  EEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQER-QLAEQERRRE 727
            E E+++LR     ++    RE+E+  QER EQ+ R Q+R  + R E+E+ QL EQE+R  
Sbjct: 1782 EREEQQLRSQESDRKF---REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLR 1838

Query: 728  QER---LQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 781
            QER    +AE +   +EK+ R ++++L +E E+K+++E +++L E  ++ +Q+++ +
Sbjct: 1839 QERDRQYRAEEQFATQEKS-RREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894



 Score =  125 bits (315), Expect = 1e-28
 Identities = 87/263 (33%), Positives = 153/263 (58%), Gaps = 26/263 (9%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
           E+E +R + L+R+EE E+L+++   E + RR +E +  RE+ L++  + R   E+ ++  
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEER--REQLLKREEEKRLEQERREQRL 567

Query: 596 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 655
           K++ E++  Q+ ++ E+ +++RL  E+ ++     K EEVE  R ++EE R  R  ++E 
Sbjct: 568 KREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE--RLEQEERREQRLKREEP 625

Query: 656 EERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE-RREQERREQERREQERREQERRE 714
           EE R Q+LL   K EEQE  R+    +   E+REQ  +RE+E    E+R +   E+ERRE
Sbjct: 626 EEERRQQLL---KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE 682

Query: 715 QERQLAEQERRRE---------QERLQAERELQEREKALRLQKEQLQR---ELEEKKKKE 762
           QE    EQE+ RE         Q +L++E + ++ +   R +K++ QR   E EEK+++ 
Sbjct: 683 QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742

Query: 763 E------QQRLAERQLQEEQEKK 779
           E      ++  A RQ QEE++++
Sbjct: 743 ESELQWQEEERAHRQQQEEEQRR 765



 Score =  124 bits (312), Expect = 3e-28
 Identities = 105/349 (30%), Positives = 185/349 (53%), Gaps = 19/349 (5%)

Query: 443  PPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRN 502
            PP   +R+R  +    +  E++ L +EE +  R +         + +      L   +R 
Sbjct: 788  PPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ-LQRRERA 846

Query: 503  QMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSF-VEKERQRLENLRRKEEAEQLRRQKVEE 561
            Q L       +   +   +R+   R D K  + +E+ER+R  +    + A  L+ Q  +E
Sbjct: 847  QQLQEEEDGLQEDQER--RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA--LQEQLRKE 902

Query: 562  DKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEE 621
             +  + EE +L+REER ++  Q +ER  Q +EE++ Q E++    +E+ ++ ++ER  + 
Sbjct: 903  QQLLQEEEEELQREEREKRRRQEQER--QYREEEQLQQEEEQLLREEREKRRRQERERQY 960

Query: 622  KAKKKAAAKKM----EEVEARRKQEEEA--RRLRWLQQEEEERRHQELLQKKKEEEQERL 675
            +  KK   K+     EE E RR+QE E   R    LQQEEE+   +E  +++++E + + 
Sbjct: 961  RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQY 1020

Query: 676  RKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAER 735
            RK  E ++  EQ  +E RE +RR QER  Q R E+E +++E QL  +E  RE  R Q   
Sbjct: 1021 RKKDELQQEEEQLLREERE-KRRLQERERQYREEEELQQEEEQLLGEE--RETRRRQELE 1077

Query: 736  ELQEREKALRLQKEQLQRELEEKKKKEEQQRLA--ERQLQEEQEKKAKE 782
                +E+ L+ ++EQL RE  EK++++E++R    E +LQ+E+E+  +E
Sbjct: 1078 RQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE 1126



 Score =  123 bits (308), Expect = 9e-28
 Identities = 93/275 (33%), Positives = 157/275 (57%), Gaps = 43/275 (15%)

Query: 537  KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQM----K 592
            +E+ R E    +EE E+L+R+  E +KRRR E+ +  REE      Q ++  EQ+    +
Sbjct: 896  QEQLRKEQQLLQEEEEELQRE--EREKRRRQEQERQYREEE-----QLQQEEEQLLREER 948

Query: 593  EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 652
            E++++Q  ++  + D+K ++ +E+ L EE  K++   ++ +  E    Q+EE + LR   
Sbjct: 949  EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLR--- 1005

Query: 653  QEEEERRHQEL---LQKKKE---EEQERLRKAAEAKRLAEQREQERREQE---------- 696
            +E E+RR QE     +KK E   EE++ LR+  E +RL E+  Q R E+E          
Sbjct: 1006 EEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065

Query: 697  -----RREQERREQERREQERREQERQL--AEQERRREQERLQAERELQEREKALRLQKE 749
                 RR QE   Q R+E+E +++E QL   E E+RR QER   ER+ +E E+ L+ ++E
Sbjct: 1066 EERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER---ERQCREEEE-LQQEEE 1121

Query: 750  QLQRELEEKKKKEEQQR--LAERQLQEEQEKKAKE 782
            QL RE  EK++++E +R    E ++Q+E+E+  +E
Sbjct: 1122 QLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156



 Score =  122 bits (307), Expect = 1e-27
 Identities = 114/408 (27%), Positives = 205/408 (50%), Gaps = 58/408 (14%)

Query: 429  QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
            +QE + +Q    RE P+  RR++  K    E   +Q L  E+ Q  R +         ++
Sbjct: 611  EQEERREQRL-KREEPEEERRQQLLKSEEQEERRQQQLRREQ-QERREQRLKREEEEERL 668

Query: 489  VRPLRTFLHTVQRNQMLMTPTSAP-RSVMKSFIK------------RNTPLRMDPKCSFV 535
             + L+      +R Q L        R  +KS I             R + +   P+    
Sbjct: 669  EQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEG 728

Query: 536  EKERQRLENLRRKEEAE-------QLRRQKVEEDKRRRL--EEVKLKREERLRKVLQAR- 585
            ++ RQ  E  RR+ E+E       +  RQ+ EE++RR    +    ++ ER R+ L AR 
Sbjct: 729  QRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARP 788

Query: 586  ----ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLA----------EEKAKKKAAAKK 631
                +R  Q++ E+++Q EQ+F   +E+ E+ + +R            EE+ +++  A++
Sbjct: 789  PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848

Query: 632  MEEVE-------ARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRL 684
            ++E E        RR+ +E+ R  +W  Q EEER+ +      K   QE+LRK  E + L
Sbjct: 849  LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRK--EQQLL 906

Query: 685  AEQREQ---ERREQERREQERREQERREQERREQERQLAEQ-ERRREQER---LQAEREL 737
             E+ E+   E RE+ RR+++ R+    EQ ++E+E+ L E+ E+RR QER    + +++L
Sbjct: 907  QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966

Query: 738  QEREKALRLQKEQLQRELEEKKK---KEEQQRLAERQLQEEQEKKAKE 782
            Q++E+ L  ++ + +R  E +KK   +EE Q+  E+ L+EE+EK+ ++
Sbjct: 967  QQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014



 Score =  122 bits (306), Expect = 2e-27
 Identities = 112/406 (27%), Positives = 202/406 (49%), Gaps = 81/406 (19%)

Query: 441  REPPQSARRKRSYKQAVSELDEEQHLEDEELQPP-RSKTPSSPCPASKVVRPLRTFLHTV 499
            RE  Q  R++R  K     L+EEQ L  +E     R +   S  P  K +   +  LH  
Sbjct: 1473 REEQQLHRQERDRKF----LEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQ-LHRQ 1527

Query: 500  QRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKV 559
            QR +  +      R       +R    R D    F E+E+     LR++ E +QL RQ  
Sbjct: 1528 QRQRKFLQEEQQLRRQ-----ERGQQRRQDRDRKFREEEQ-----LRQEREEQQLSRQ-- 1575

Query: 560  EEDKRRRLEEVKLKREERLRKVLQARE--RVEQMKEEKKKQIEQKFAQIDEKTEKAKEER 617
            E D++ RLEE K++R+E+ RK ++  +  R ++ +++ +++ ++KF + ++  ++ +E++
Sbjct: 1576 ERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQ 1635

Query: 618  L----------------------------------AEEKAKKKAAAKKMEEVEARRKQEE 643
            L                                   EE+  ++   +++   E  RK  E
Sbjct: 1636 LHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695

Query: 644  EARRLRWLQ------QEEEERRHQELLQKKKEEE-------------QERLRKAAEAKRL 684
            E ++LR  +      QEE++ R QEL +K +EEE             QER RK  E ++L
Sbjct: 1696 EEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQL 1755

Query: 685  AEQREQERREQERREQERREQERREQERREQERQLAEQERR-REQERLQAERE-----LQ 738
              +RE+++  ++ R+++ RE+E+  QER EQ+ +  E +R+ RE+E+L+ ERE      Q
Sbjct: 1756 RPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQ 1815

Query: 739  EREKALRLQKEQLQRELEEKKKKEEQQR--LAERQLQEEQEKKAKE 782
            +R+   R ++EQLQ E +E++ ++E+ R   AE Q   +++ + +E
Sbjct: 1816 QRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE 1861



 Score =  121 bits (303), Expect = 3e-27
 Identities = 111/399 (27%), Positives = 202/399 (50%), Gaps = 68/399 (17%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
           +Q+ K DQ        +  RR+R  K    E  E+Q   +++L+  + +         + 
Sbjct: 473 KQQLKRDQ--------EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEE 524

Query: 489 VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRK 548
              L+  L +    Q L       R   +  +KR    R++      E+  QRL     K
Sbjct: 525 EERLQQRLRS---EQQLRREQEERR---EQLLKREEEKRLEQ-----ERREQRL-----K 568

Query: 549 EEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDE 608
            E E+ R Q ++ ++ RR + +K ++EERL + L+ RE VE++++E++++   K  + +E
Sbjct: 569 REQEERRDQLLKREEERRQQRLKREQEERLEQRLK-REEVERLEQEERREQRLKREEPEE 627

Query: 609 -KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL--RWLQQEEEERRHQELLQ 665
            + ++  +    EE+ +++   ++ E  E R K+EEE  RL  R  ++ EEERR QEL +
Sbjct: 628 ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE 687

Query: 666 KKKEEEQERLRK--------------AAEAKRLAEQREQE---RREQERREQERREQERR 708
           +++E+ +ER++               A ++K  +  R+QE   RR+++  ++ RRE E +
Sbjct: 688 EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ 747

Query: 709 EQERREQERQLAEQERRRE--------------QERLQAERELQE-REKALRLQKEQL-- 751
            QE     RQ  E+E+RR+              ++RL A   L+E RE+ LR ++ Q   
Sbjct: 748 WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQRE 807

Query: 752 QRELEEKKKKEE---QQRLAERQLQ---EEQEKKAKEAA 784
           QR L E+++KE+   Q+R  E++LQ   EE++ + +E A
Sbjct: 808 QRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERA 846



 Score =  120 bits (300), Expect = 8e-27
 Identities = 109/385 (28%), Positives = 197/385 (51%), Gaps = 48/385 (12%)

Query: 429  QQEAKTDQADGPREPPQSARRKRSYKQAVSELD-----EEQHLEDEELQPPRSKTPSSPC 483
            Q+EAK       +E  Q  R +R  K+   E D     EEQ L++ E QP R +      
Sbjct: 1304 QKEAKRRDRKS-QEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKF 1362

Query: 484  PASKVVRPL--RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQR 541
               ++      R FL   QR +         +   + F+K    LR   +   + ++R R
Sbjct: 1363 REEELRHQEQGRKFLEEEQRLRR--------QERERKFLKEEQQLRCQEREQQLRQDRDR 1414

Query: 542  LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQ 601
                + +EE +QL RQ  E D++ R EE +++R+ER RK L+  +++ Q +  K ++ EQ
Sbjct: 1415 ----KFREEEQQLSRQ--ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468

Query: 602  KFAQIDE----KTEKAK-----EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 652
               + +E    + E+ +     E++L  ++  +K   +++   E  RK  EE ++L   Q
Sbjct: 1469 LLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528

Query: 653  ------QEEEERRHQELLQKKKEE------EQERLRKAAEAKRLAEQREQERREQERREQ 700
                  QEE++ R QE  Q+++++      E+E+LR+  E ++L+ Q    +   E ++ 
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKV 1588

Query: 701  ERREQERREQERREQ-ERQLAEQERRREQERLQAERE--LQEREKALRLQKEQLQRELEE 757
             R+EQER+  E  +Q  RQ  +Q+ R+E++R   E E  LQERE+    ++E+ ++ LEE
Sbjct: 1589 RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE 1648

Query: 758  KKKKEEQQRLAERQLQEEQEKKAKE 782
            + +   Q+R  E+QL+ ++++K +E
Sbjct: 1649 EPQLRRQER--EQQLRHDRDRKFRE 1671



 Score =  118 bits (296), Expect = 2e-26
 Identities = 88/280 (31%), Positives = 156/280 (55%), Gaps = 43/280 (15%)

Query: 536  EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQM---- 591
            E+ERQ  E  + ++E EQL R+  E +KRRR E     RE + RK  + +++ EQ+    
Sbjct: 925  EQERQYREEEQLQQEEEQLLRE--EREKRRRQE-----RERQYRKDKKLQQKEEQLLGEE 977

Query: 592  KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAA-----KKMEEVEARRKQE-EEA 645
             E++++Q  +K  + +E+ ++ +E+ L EE+ K++        +K +E++   +Q   E 
Sbjct: 978  PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037

Query: 646  RRLRWLQQEEEERRHQELLQKKKEE---EQERLRKAAEAKRLAEQREQERREQE------ 696
            R  R LQ+ E + R +E LQ+++E+   E+   R+  E +R   + E+ ++E+E      
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097

Query: 697  ---RREQERREQERREQERREQERQLAEQERR-----------REQERLQAERELQEREK 742
               RR QER  Q R E+E +++E QL  +ER            RE+E +Q E E   RE+
Sbjct: 1098 PEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREE 1157

Query: 743  ALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
              + ++++L+R+  E   +EE Q+  E+ L+EEQEK+ +E
Sbjct: 1158 PEKRRRQELERQYRE---EEELQQEEEQLLREEQEKRRQE 1194



 Score =  117 bits (293), Expect = 5e-26
 Identities = 83/250 (33%), Positives = 148/250 (59%), Gaps = 16/250 (6%)

Query: 536  EKERQRLENLRRKEEAEQLRRQ----KVEEDKRRRLEEVKLKREERLRKVLQARERVEQM 591
            +K+ Q+ E     EE E+ RRQ    K  E++  + EE +L REER ++  Q  ER  + 
Sbjct: 963  DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022

Query: 592  KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKM--EEVEARRKQEEEA--RR 647
            K+E +++ EQ   +  EK    + ER   E+ + +   +++  EE E RR+QE E   R+
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082

Query: 648  LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQER 707
               LQQEEE+   +E  +++++E + + R+  E ++  EQ  +E RE+ RR++  R+   
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYRE 1142

Query: 708  REQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRL 767
             E+ ++E+E+ L E+  +R ++ L  ER+ +E E+ L+ ++EQL RE E++K+++E+   
Sbjct: 1143 EEEVQQEEEQLLREEPEKRRRQEL--ERQYREEEE-LQQEEEQLLRE-EQEKRRQER--- 1195

Query: 768  AERQLQEEQE 777
             ERQ +EE+E
Sbjct: 1196 -ERQYREEEE 1204



 Score =  115 bits (289), Expect = 1e-25
 Identities = 107/401 (26%), Positives = 204/401 (50%), Gaps = 74/401 (18%)

Query: 429  QQEAKTDQADGPREPPQSARRK---RSYKQAVSELDEEQHL---EDEELQPPRSKTPSSP 482
            QQ ++ ++    RE  Q  RR+   R + +   +L +E+H    E+E+L   R +     
Sbjct: 1421 QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ--- 1477

Query: 483  CPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLR-MDPKCSFVEKERQR 541
                         LH  +R++  +      R   +    R   LR  +P+  F+E+E+Q 
Sbjct: 1478 -------------LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524

Query: 542  LENLRRK---EEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ 598
                R++   +E +QLRRQ+    +RR+  + K + EE+LR   Q RE  +  ++E+   
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQE-RGQQRRQDRDRKFREEEQLR---QEREEQQLSRQER--- 1577

Query: 599  IEQKFAQIDEKTEKAKEERLA---EEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 655
             ++KF   ++K  + ++ER     E++ +++   +++ +   R+ +E+E    + LQ+ E
Sbjct: 1578 -DRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDE----QLLQERE 1632

Query: 656  EERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER--- 712
            E++ H++   +K  EE+ +LR+    ++L   R+++ RE+E+  QE  EQ+ R QER   
Sbjct: 1633 EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK 1692

Query: 713  -REQERQLAEQERRR-------------------EQERLQAERELQEREKALR----LQK 748
             RE+E+QL  QER R                   E+E+L+ E E ++  +  R    L++
Sbjct: 1693 FREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEE 1752

Query: 749  EQLQRELEEK--KKKEEQQRLAE----RQLQEEQEKKAKEA 783
            EQL+ E EE+  +++E  ++  E    RQ +EEQ+ +++E+
Sbjct: 1753 EQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQES 1793



 Score =  114 bits (286), Expect = 3e-25
 Identities = 107/400 (26%), Positives = 195/400 (48%), Gaps = 53/400 (13%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLE-DEELQPPRSKTPSSPCPASK 487
           +Q+ + +Q +  RE  Q  RR++  ++   +L  EQ L  +++L+  +           +
Sbjct: 348 EQQLRREQEEERRE--QQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405

Query: 488 VVRPLRTFLHTVQ--RNQMLMTPTSAPRSVMKSFIKRNTP------------LRMDPKCS 533
            +R  +      Q  R Q L       R   K   +R               L+ + +  
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE 465

Query: 534 FVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKE 593
             E+ER++ +  R +EE  + R  K+EE++RR  +E   +RE++LR+  + R      ++
Sbjct: 466 RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE---RREQQLRREQEERREQRLKRQ 522

Query: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ 653
           E++++++Q+    +++  + +EER  +   +++    + E  E R K+E+E RR + L++
Sbjct: 523 EEEERLQQRLRS-EQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKR 581

Query: 654 EEEER-----RHQE--LLQKKKEEEQERL-----------RKAAEAKR----LAEQREQE 691
           EEE R     R QE  L Q+ K EE ERL           R+  E +R    L  + ++E
Sbjct: 582 EEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641

Query: 692 RREQE--RREQERREQ---ERREQERREQERQLAEQERRREQERLQAERELQEREKALRL 746
           RR+Q+  R +QERREQ      E+ER EQ  +   +E RREQE  + E+E        R+
Sbjct: 642 RRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRI 701

Query: 747 QKEQLQRELEEKKKKEE-----QQRLAERQLQEEQEKKAK 781
            K Q Q E E   ++ +     +++  +R+ QE++EK+ +
Sbjct: 702 PKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRR 741



 Score =  114 bits (285), Expect = 4e-25
 Identities = 114/435 (26%), Positives = 208/435 (47%), Gaps = 44/435 (10%)

Query: 374  EQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPN------PKPAASSPETPSA 427
            +++E  +E E +   EPE             + E+             K      E    
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141

Query: 428  GQQEAKTDQADGPREPPQSARRK---RSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCP 484
             ++E + ++    RE P+  RR+   R Y++      EE+ L  EE +  R +       
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYRE 1201

Query: 485  ASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLEN 544
              ++ R  R   +  +  +  +     P        K N        C   E E+ R   
Sbjct: 1202 EEELQRQKRKQRYRDEDQRSDLKWQWEPE-------KENAVRDNKVYCKGRENEQFR--- 1251

Query: 545  LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER----VEQMKEEKKKQIE 600
               + E  QLR ++ ++D +  L E + +  E+ R+  Q R+R     EQ++ E++K+ +
Sbjct: 1252 ---QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAK 1308

Query: 601  QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA---RRLRWLQQEEEE 657
            ++  +  E+ +  +EER  EEK +++   +K  E E   ++ EE    R+ R  +  EEE
Sbjct: 1309 RRDRKSQEEKQLLREER--EEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEE 1366

Query: 658  RRHQELLQKKKEEEQERLRKAAEAKRLAEQRE---QERREQERREQERREQERREQ-ERR 713
             RHQE  +K  EEEQ   R+  E K L E+++   QER +Q R++++R+ +E  +Q  R+
Sbjct: 1367 LRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQ 1426

Query: 714  EQERQLAEQE---RRREQER--LQAEREL-QEREKALRLQKEQLQRELEEKKKKEEQQRL 767
            E++R+  E+E   RR+E+ER  L+ E++L QER +  R +++ LQ   E++  ++E+ R 
Sbjct: 1427 ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR- 1485

Query: 768  AERQLQEEQEKKAKE 782
              + L+EEQ+ + +E
Sbjct: 1486 --KFLEEEQQLRRQE 1498



 Score =  112 bits (281), Expect = 1e-24
 Identities = 79/258 (30%), Positives = 152/258 (58%), Gaps = 15/258 (5%)

Query: 536  EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
            E++++     R+ +E +QL R++ EE +RR+  + K + EE+L   LQ RE     ++E+
Sbjct: 1302 EEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQL---LQEREEQPLRRQER 1358

Query: 596  KKQIEQKFAQIDEKTEK--AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ 653
             ++  ++  +  E+  K   +E+RL  ++ ++K   ++ +     R+Q+    R R  ++
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418

Query: 654  EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE-QERREQERREQERREQERREQE- 711
            EE++   QE  +K +EEEQ+  R+  E K L E+++ ++ R ++ RE+E+  QER EQ+ 
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQL 1478

Query: 712  -RREQERQLAEQE---RRREQERLQAEREL--QEREKALRLQKEQLQRELEEKK--KKEE 763
             R+E++R+  E+E   RR+E++R   E+EL  QE E+    +++QL R+  ++K  ++E+
Sbjct: 1479 HRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQ 1538

Query: 764  QQRLAERQLQEEQEKKAK 781
            Q R  ER  Q  Q++  K
Sbjct: 1539 QLRRQERGQQRRQDRDRK 1556



 Score =  112 bits (280), Expect = 2e-24
 Identities = 87/268 (32%), Positives = 157/268 (58%), Gaps = 24/268 (8%)

Query: 536  EKERQRLENLRRK-EEAEQLRRQKVEEDKRR---RLEEVKLKREERLRKVLQARERVEQM 591
            E+ER+R +   R   E EQL R++ +E KRR     EE +L REER  K  + R+  ++ 
Sbjct: 1280 EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK--RRRQETDRK 1337

Query: 592  KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 651
              E+++ ++++  Q   + E+ ++ R  EE   ++   K +EE +  R+QE E + L+  
Sbjct: 1338 FREEEQLLQEREEQPLRRQERDRKFR-EEELRHQEQGRKFLEEEQRLRRQERERKFLKEE 1396

Query: 652  QQEEEERRHQELLQ----KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQER 707
            QQ   + R Q+L Q    K +EEEQ+  R+  + K   E+++  R+E+ER+  E  +Q R
Sbjct: 1397 QQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLR 1456

Query: 708  REQER--REQERQLAEQER----RREQER--LQAERELQEREKALRLQKEQLQRELEEKK 759
            +E+ R  RE+E+ L E+E     R+E++R  L+ E++L+ +E+  + ++++L+ +  E+K
Sbjct: 1457 QERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERK 1516

Query: 760  KKEEQQRLAERQ-----LQEEQEKKAKE 782
              EE+Q+L  +Q     LQEEQ+ + +E
Sbjct: 1517 FLEEEQQLHRQQRQRKFLQEEQQLRRQE 1544



 Score =  110 bits (274), Expect = 8e-24
 Identities = 180/775 (23%), Positives = 316/775 (40%), Gaps = 98/775 (12%)

Query: 35   EEIQEE--AERMFTREFSKEPELMPKTPSQKN---RRKKRRISYVQDENRDPI-RRRLSR 88
            E +Q+   +E+   RE  +  E + K   +K     R+++R+   Q+E RD + +R   R
Sbjct: 526  ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEER 585

Query: 89   RKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATMALAAPSSPTPES 148
            R+ R  +    RL  +   E++  +  E     RR  R                 P  E 
Sbjct: 586  RQQRLKREQEERLEQRLKREEVERLEQEE----RREQRLKR------------EEPEEER 629

Query: 149  PTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTS 208
               L K  E    + Q     ++   +++  EQ + +    E L + L            
Sbjct: 630  RQQLLKSEEQEERRQQ-----QLRREQQERREQRLKREEEEERLEQRLKREHEEERR--E 682

Query: 209  QGIPTSDEESTPKKSKARI------LES---ITVSSLMATPQDPKGQGVGTGRSASKLRI 259
            Q +   ++E   ++ K+RI      LES      S + + P+  +GQ     +   + R 
Sbjct: 683  QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742

Query: 260  AQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLA 319
                    +  A       E+        +F+    +   S+  R       S  P +  
Sbjct: 743  ESELQWQEEERAHRQQQEEEQ------RRDFTWQWQAEEKSERGRQR----LSARPPLRE 792

Query: 320  QKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVE-VPQKVGSEQKEP 378
            Q+   +  +E   +R  R L ++  +E     R      L+ L   E + ++  ++Q + 
Sbjct: 793  QRERQLRAEERQ-QREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851

Query: 379  PEEAEPVAAAEPEVPENNGNNSWP---HNDTEIANSTPNPKPAASSPETPSAGQQEAKTD 435
             E+            E   +  W      + +    T   KPA    E     QQ  + +
Sbjct: 852  EEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQ--EQLRKEQQLLQEE 909

Query: 436  QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF 495
            + +  RE  +  RR+   +Q      EE+ L+ EE Q  R +         +  R  R  
Sbjct: 910  EEELQREEREKRRRQEQERQ----YREEEQLQQEEEQLLREEREKRRRQERE--RQYRKD 963

Query: 496  LHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLR 555
                Q+ + L+      R   +   K              E+E Q+ E    +EE E+ R
Sbjct: 964  KKLQQKEEQLLGEEPEKRRRQEREKKYRE-----------EEELQQEEEQLLREEREKRR 1012

Query: 556  RQKVEEDKRRR----LEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTE 611
            RQ+ E   R++     EE +L REER ++ LQ RER  + +EE +++ EQ   +  E   
Sbjct: 1013 RQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRR 1072

Query: 612  KAKEERL--AEEKAKKKAAAKKMEEVEARRKQEEE--ARRLRWLQQEEEERRHQELLQKK 667
            + + ER    EE+ +++      EE E RR+QE E   R    LQQEEE+   +E  +++
Sbjct: 1073 RQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR 1132

Query: 668  KEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRRE 727
            ++E + + R+  E ++  EQ  +E  E+ RR QE   Q R E+E +++E QL     R E
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEPEKRRR-QELERQYREEEELQQEEEQLL----REE 1187

Query: 728  QERLQAERELQEREKALRLQKEQLQRELEEKKKKE---EQQRLAERQLQEEQEKK 779
            QE+ + ERE Q RE          + EL+ +K+K+   ++ + ++ + Q E EK+
Sbjct: 1188 QEKRRQERERQYRE----------EEELQRQKRKQRYRDEDQRSDLKWQWEPEKE 1232



 Score =  108 bits (269), Expect = 3e-23
 Identities = 78/264 (29%), Positives = 154/264 (58%), Gaps = 24/264 (9%)

Query: 527 RMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARE 586
           R D K S ++  RQ  E+ RR E  +   RQ  EE  +RR +    KR+E+ R++ +  E
Sbjct: 102 RCDGKESLLQDRRQE-EDQRRFEPRD---RQLEEEPGQRRRQ----KRQEQERELAEGEE 153

Query: 587 RVEQMKE----EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV----EAR 638
           + E+ +     +++++ E+ + Q  E  E+  EER AEE+  +     + EE     + R
Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQRQEWQER--EERRAEEEQLQSCKGHETEEFPDEEQLR 211

Query: 639 RKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 698
           R++  E RR    +++++ R  Q+ + +  EEE++  RK     R  E++ QE   Q +R
Sbjct: 212 RRELLELRRKGREEKQQQRRERQDRVFQ--EEEEKEWRKRETVLRKEEEKLQEEEPQRQR 269

Query: 699 EQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK 758
           E +  E++ R+ ER+E  R+   QE  ++Q+RL+ E++L+ +++  R ++++ +RE +E+
Sbjct: 270 ELQEEEEQLRKLERQELRRE--RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER 327

Query: 759 KKKEEQQRLAERQLQEEQEKKAKE 782
           ++++E++R  E+QL+ EQE++ ++
Sbjct: 328 REQQEERR--EQQLRREQEERREQ 349



 Score =  107 bits (268), Expect = 4e-23
 Identities = 116/496 (23%), Positives = 232/496 (46%), Gaps = 34/496 (6%)

Query: 304  RHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLL 363
            RH+  A  +   Q L ++  L+ ++E  ++R  R   ++  +E             E+LL
Sbjct: 886  RHTLYAKPALQEQ-LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944

Query: 364  NVEVPQKVGSEQ-------KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPK 416
              E  ++   E+       K+  ++ E +   EPE             + E+       +
Sbjct: 945  REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE--EEQ 1002

Query: 417  PAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRS 476
                  E     + E +  + D  ++  +   R+   K+ + E  E Q+ E+EELQ    
Sbjct: 1003 LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER-ERQYREEEELQQEEE 1061

Query: 477  KTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVE 536
            +         +  R  +      ++ + L         +++   ++      + +C   E
Sbjct: 1062 QLLGE----ERETRRRQELERQYRKEEELQ---QEEEQLLREEPEKRRRQERERQCREEE 1114

Query: 537  KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVE---QMKE 593
            + +Q  E L R EE E+ RRQ++E   R   EEV+ + E+ LR+  + R R E   Q +E
Sbjct: 1115 ELQQEEEQLLR-EEREKRRRQELERQYREE-EEVQQEEEQLLREEPEKRRRQELERQYRE 1172

Query: 594  EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ 653
            E++ Q E++   + E+ EK ++ER  + + +++   +K ++   R + E++   L+W  +
Sbjct: 1173 EEELQQEEE-QLLREEQEKRRQERERQYREEEELQRQKRKQ---RYRDEDQRSDLKWQWE 1228

Query: 654  EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER-REQERREQER 712
             E+E   ++     K  E E+ R+  +++    Q +Q+ +     +QER REQERR  ++
Sbjct: 1229 PEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQ 1288

Query: 713  REQERQLAEQ-ERRREQERLQAERELQEREKALRLQKEQLQRELE-EKKKKEEQQRLAER 770
            R++     EQ ER  ++E  + +R+ QE ++ LR ++E+ +R  E ++K +EE+Q L ER
Sbjct: 1289 RDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQER 1348

Query: 771  QLQ----EEQEKKAKE 782
            + Q    +E+++K +E
Sbjct: 1349 EEQPLRRQERDRKFRE 1364



 Score =  107 bits (267), Expect = 5e-23
 Identities = 73/229 (31%), Positives = 139/229 (60%), Gaps = 20/229 (8%)

Query: 567 LEEVKLKREERLRKVLQARERVEQMK--EEKKKQIEQKFAQIDEKTEKAKEERLAE--EK 622
           L+E K  R +    +LQ R + E  +  E + +Q+E++  Q   +  + +E  LAE  E+
Sbjct: 95  LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154

Query: 623 AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK--------EEEQER 674
           ++K+   +++E+ + +R+ EE  R+ +  Q+ EE R  +E LQ  K        +EEQ R
Sbjct: 155 SEKQ---ERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLR 211

Query: 675 LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE 734
            R+  E +R   +  +E+++Q R  Q+R  QE  E+E R++E  L ++E + ++E  Q +
Sbjct: 212 RRELLELRR---KGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268

Query: 735 RELQEREKALR-LQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
           RELQE E+ LR L++++L+RE +E+++++++ R  E+QL+ +QE++ +E
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLR-REQQLRRKQEEERRE 316



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 65/273 (23%), Positives = 133/273 (48%), Gaps = 20/273 (7%)

Query: 429  QQEAKTDQADGP-REPPQSARRKRSYKQAVSELDEEQHLEDEELQPP-RSKTPSSPCPAS 486
            +Q+ +  + D   RE  Q  RR+   ++    L EEQ L  +EL+   R +         
Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQERERKF---LQEEQQLRRQELERKFREEEQLRQETEQ 1737

Query: 487  KVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRL---E 543
            + +R    +   ++  Q+   P    + + +   +R+   R + +    E+E Q+L   E
Sbjct: 1738 EQLRRQERYRKILEEEQL--RPEREEQQLRRQ--ERDRKFREEEQLR-QEREEQQLRSQE 1792

Query: 544  NLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ--IEQ 601
            + R+  E EQLR+++ E+  R +  + K + EE   + LQ  E+ +++++E+ +Q   E+
Sbjct: 1793 SDRKFREEEQLRQEREEQQLRPQQRDGKYRWEE---EQLQLEEQEQRLRQERDRQYRAEE 1849

Query: 602  KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ-QEEEERRH 660
            +FA  ++   + +E    EE+ +++   +K+ E   RR+Q+EE R  +  + + +E + H
Sbjct: 1850 QFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGH 1909

Query: 661  QELLQKKKEE-EQERLRKAAEAKRLAEQREQER 692
              LL+    +     +R +   + + EQR Q R
Sbjct: 1910 GRLLEPGTHQFASVPVRSSPLYEYIQEQRSQYR 1942



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 39/109 (35%), Positives = 64/109 (58%), Gaps = 9/109 (8%)

Query: 680 EAKRLAEQREQERREQERREQERREQERREQERRE-QERQLAEQE-RRREQERLQAEREL 737
           +A  L E++      +E   Q+RR++E  +Q R E ++RQL E+  +RR Q+R + EREL
Sbjct: 91  QATGLDEEKRARCDGKESLLQDRRQEE--DQRRFEPRDRQLEEEPGQRRRQKRQEQEREL 148

Query: 738 ----QEREKALRLQKEQLQRELEEK-KKKEEQQRLAERQLQEEQEKKAK 781
               ++ EK  RL++   QR  EE  ++++E Q   ER+ +EEQ +  K
Sbjct: 149 AEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK 197



 Score = 31.6 bits (70), Expect = 3.5
 Identities = 23/88 (26%), Positives = 45/88 (51%), Gaps = 11/88 (12%)

Query: 33   WLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDP------IRRRL 86
            +L+E Q+   +   R+F +E +L  +T  ++ RR++R    +++E   P      +RR+ 
Sbjct: 1709 FLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQE 1768

Query: 87   SRRKSRS-----SQLSSRRLRSKDSVEK 109
              RK R       +   ++LRS++S  K
Sbjct: 1769 RDRKFREEEQLRQEREEQQLRSQESDRK 1796


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score =  131 bits (329), Expect = 3e-30
 Identities = 94/287 (32%), Positives = 172/287 (59%), Gaps = 44/287 (15%)

Query: 536 EKERQRLENLRRKEEA-----EQLRRQKV----EEDKRRRLEEVKLKREERLRKVLQARE 586
           EK R++ E +RR+EE      E++RRQ+     +E+K RRLEE+  ++EE++R++ +   
Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMH 387

Query: 587 RVEQMKE-EKKKQIEQKFAQIDEKTEKA-----KEERLAEEKAKKKAAAKKMEEVEARRK 640
             E+++E E+K+Q E+K  + +++ E+      +EE++ E++ K +   KKM   E +  
Sbjct: 388 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH 447

Query: 641 QEEEARRLRWLQQEEEERRHQELL--------QKKKEEEQERLRKAAEA-----KRLAEQ 687
           ++E+ R     Q++EE  R +E +        QK+K  EQE++RK  E      +++ +Q
Sbjct: 448 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQ 507

Query: 688 REQERREQE---RREQERREQER--REQER--REQERQLAEQERR--------REQERLQ 732
            E+ R ++E   R+E++ REQE   REQE   REQE  + EQE +        +EQE+++
Sbjct: 508 EEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMR 567

Query: 733 AERE-LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 778
            + E ++E+E+ +R QKE+++ + E+  ++EE+ R  E  +QE++EK
Sbjct: 568 RQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEK 614



 Score =  124 bits (312), Expect = 3e-28
 Identities = 83/265 (31%), Positives = 165/265 (62%), Gaps = 28/265 (10%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKV----EEDKRRRLEEVKLKREERLRKVLQARERVEQM 591
           EK R++ E +R +EE  ++RRQ+     +E+K RR EE+  ++EE++R++    E +   
Sbjct: 321 EKIREQEEKIREQEE--KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRL----EEMMWE 374

Query: 592 KEEKKKQIEQKFAQ---IDEKTEKAKEE-RLAEEKAKKKAAAKKMEEVEARRKQEEEARR 647
           KEEK +++E+K  +   I E+ EK +EE ++ E++ +++  AK   + E  R+QEE+ R 
Sbjct: 375 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 434

Query: 648 LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER-REQE 706
                  +EE+ H++   +++E+ QE+     + +++ EQ E  R++++  EQE+ R+QE
Sbjct: 435 QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQE 494

Query: 707 ----RREQERREQERQLAEQERR--REQERLQAERE-LQEREKALRLQKEQLQR------ 753
               R+E++  +QE ++ EQE +  R++E+++ + E ++E+E+ +R Q+E +Q       
Sbjct: 495 EKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMG 554

Query: 754 ELEEKKKKEEQQRLAERQLQEEQEK 778
           E EEK +++E+ R  E +++E++EK
Sbjct: 555 EQEEKMQEQEKMRRQEEKIREQEEK 579



 Score =  121 bits (304), Expect = 3e-27
 Identities = 104/467 (22%), Positives = 231/467 (49%), Gaps = 42/467 (8%)

Query: 318 LAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKE 377
           L +K  LV  ++S ++   + L +K                LER   +   Q++ +E   
Sbjct: 226 LQEKLQLVESEKSEIQLNVKELKRK----------------LERAKLLLPQQQLQAEADH 269

Query: 378 PPEEAEPVAAA-EPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQ 436
             +E + V+A  + +V EN     W   + +        +      E     Q+E   +Q
Sbjct: 270 LGKELQSVSAKLQAQVEENE---LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ 326

Query: 437 ADGPREPPQSARRKRSYKQAVSELDEEQHLEDE---ELQPPRSKTPSSPCPASKVVRPLR 493
            +  RE  +  RR+   ++ + E +E+   ++E   E +    +         + +R L 
Sbjct: 327 EEKIREQEEKMRRQ---EEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELE 383

Query: 494 TFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQ 553
             +H  ++ +           + +   ++    +M  +    EK R++ E +R +E+   
Sbjct: 384 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ---EEKIREQEEKIREQEKKMW 440

Query: 554 LRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKA 613
            + +K+ E ++ R EE + ++EE  R+  + RE+ E  ++++K   ++K  + +EK  + 
Sbjct: 441 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQ 500

Query: 614 KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQE 673
           +E+   +E+  ++   K   + E  R+QEE+ R     +QEE+ R  +E++Q+++E+  E
Sbjct: 501 EEKMHDQEEKIREQEEKMWRQEEKIREQEEKIR-----EQEEKIREQEEMMQEQEEKMGE 555

Query: 674 RLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQA 733
                 + +++ EQ +  R+E++ REQE + +E++E+ R ++E+   ++E+ REQE +  
Sbjct: 556 ------QEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQ 609

Query: 734 ERE--LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 778
           E+E  + E+E+ +  Q+E++Q + E+ +++EE+    E +L++++EK
Sbjct: 610 EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 656



 Score =  119 bits (298), Expect = 1e-26
 Identities = 68/251 (27%), Positives = 156/251 (62%), Gaps = 11/251 (4%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERV---EQMK 592
           E++RQ  E +R +E+ ++   +   ++++ R +E K++ +E+  K+ +  E++   E+++
Sbjct: 396 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK--KMWRQEEKIHEQEKIR 453

Query: 593 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 652
           EE+K+Q +++  + +EK  + +E    +EK  ++   +K EE   R++++   +  +  +
Sbjct: 454 EEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIRE 513

Query: 653 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 712
           QEE+  R +E +++++E+ +E+  K  E + + +++E++  EQE + QE+ +  R+E++ 
Sbjct: 514 QEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKI 573

Query: 713 REQERQLAEQ-ERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ 771
           REQE ++ EQ E+ REQ     E ++ E+E+ +R Q+E +Q + E+  ++EE+    E +
Sbjct: 574 REQEEKIREQKEKIREQ-----EEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 628

Query: 772 LQEEQEKKAKE 782
           +QE++EK  ++
Sbjct: 629 MQEQEEKMRRQ 639



 Score =  114 bits (285), Expect = 4e-25
 Identities = 77/276 (27%), Positives = 162/276 (58%), Gaps = 25/276 (9%)

Query: 527 RMDPKCSFVEKERQRLE----NLRRKEEAEQL-----RRQKVEEDKRRRLEEVKLKREER 577
           ++  K   VE E+  ++     L+RK E  +L     + Q   +   + L+ V  K + +
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 284

Query: 578 LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA 637
           + +  +   R+ Q +EEK  + E+K  + +EK ++ +EE++ E++ K +   +KM   E 
Sbjct: 285 VEEN-ELWNRLNQQQEEKMWRQEEKIQEWEEKIQE-QEEKIREQEEKIREQEEKMRRQEE 342

Query: 638 RRKQEEEARR----LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR 693
              ++EE  R    + W ++EE+ RR +E++ +K+E+ +E   K  E +++ EQ E+ + 
Sbjct: 343 MMWEKEEKMRRQEEMMW-EKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE 401

Query: 694 EQERREQERREQE-----RREQERREQERQLAEQERR--REQERLQAERELQEREKALRL 746
           E++ REQE+R+++     R+E++ REQE ++ EQE++  R++E++  + +++E EK  R 
Sbjct: 402 EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK--RQ 459

Query: 747 QKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
           ++E++ R+ E+ +++EE  R  E+  ++E+ +K +E
Sbjct: 460 EQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEE 495



 Score =  114 bits (285), Expect = 4e-25
 Identities = 75/258 (29%), Positives = 160/258 (62%), Gaps = 26/258 (10%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
           EK +++ E +R +EE  ++R Q   E+K RR EE+  ++EE++R+    +E +   KEEK
Sbjct: 314 EKIQEQEEKIREQEE--KIREQ---EEKMRRQEEMMWEKEEKMRR----QEEMMWEKEEK 364

Query: 596 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV--EARRKQEEEARRLRWLQQ 653
            +++E+   + +EK  + +E+   +EK +++   ++ EE   E  ++QE+EA+  R    
Sbjct: 365 MRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR---- 420

Query: 654 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQE----RREQERREQER-- 707
           +EE+ R QE  +K +E+E++  R+  +     + RE+E+R+++    R+E++ REQE   
Sbjct: 421 QEEKIREQE--EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIW 478

Query: 708 REQERREQERQLAEQER---RREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 764
           R++E+  ++ ++ +QE    R+E++    E +++E+E+ +  Q+E+++ + E+ +++EE+
Sbjct: 479 RQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEK 538

Query: 765 QRLAERQLQEEQEKKAKE 782
            R  E  +QE++EK  ++
Sbjct: 539 IREQEEMMQEQEEKMGEQ 556



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 72/263 (27%), Positives = 151/263 (57%), Gaps = 29/263 (11%)

Query: 543 ENLRRKEEAEQLRRQKVEEDKRR-RLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQ 601
           E L+ K    Q + Q VE +K   +L   +LKR+    K+L  +++++   +   K+++ 
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 276

Query: 602 KFAQIDEKTEK---------AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 652
             A++  + E+          +EE++  ++ K +   +K++E E + +++EE      ++
Sbjct: 277 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK-----IR 331

Query: 653 QEEEERRHQELLQKKKEEEQER-----LRKAAEAKRLAE---QREQERREQERREQERRE 704
           ++EE+ R QE +  +KEE+  R       K  + +RL E   ++E++ RE E +  E +E
Sbjct: 332 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHE-QE 390

Query: 705 QERREQERREQERQLAEQERRREQE--RLQAERELQEREKALRLQKEQLQRELEEKKKKE 762
           + R ++E+R++E ++ EQE+R+EQE    + E +++E+E+ +R Q++++ R+ E+  ++E
Sbjct: 391 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE 450

Query: 763 EQQRLAERQLQEE---QEKKAKE 782
           + +   +RQ QEE   QE+K +E
Sbjct: 451 KIREEEKRQEQEEMWRQEEKIRE 473



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 75/218 (34%), Positives = 134/218 (61%), Gaps = 26/218 (11%)

Query: 536 EKERQRLENLRRKEEA----EQLRRQKV---EEDKRRRLEEVKLKREERLR-KVLQARER 587
           E++RQ  E + R+EE     E++ RQK    E++K R+ EE   ++EE++  +  + RE+
Sbjct: 455 EEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQ 514

Query: 588 VEQM--KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA 645
            E+M  +EEK ++ E+K  + +EK  + +EE + E++ K     +KM+E E  R+QEE+ 
Sbjct: 515 EEKMWRQEEKIREQEEKIREQEEKIRE-QEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKI 573

Query: 646 RRLRWLQQEEEERRHQELLQKKKE---EEQERLRKAAEAKRLAEQR--EQERR--EQERR 698
           R     +QEE+ R  +E +++++E   E++E++R+  E  +  E++  EQE +  EQE +
Sbjct: 574 R-----EQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 628

Query: 699 EQERREQERREQERR-EQERQLAEQERR--REQERLQA 733
            QE+ E+ RR++E+  EQE +L +QE +    QE L+A
Sbjct: 629 MQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 666



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 65/217 (29%), Positives = 120/217 (55%), Gaps = 40/217 (18%)

Query: 536 EKERQRLENLRRKE---EAEQLRRQKV-----------EEDKRRRLEEVKLKREERLRKV 581
           EK R++ E  R+KE   E E++R+Q+            +E+K R  EE   ++EE++   
Sbjct: 469 EKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKI--- 525

Query: 582 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ 641
              RE+ E+++E+++K  EQ             EE + E++ K     +KM+E E  R+Q
Sbjct: 526 ---REQEEKIREQEEKIREQ-------------EEMMQEQEEKMGEQEEKMQEQEKMRRQ 569

Query: 642 EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR--E 699
           EE+ R     +QEE+ R  +E +++++E+  E+  K  E + + +++E++  EQE +  E
Sbjct: 570 EEKIR-----EQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCE 624

Query: 700 QERREQERREQERREQERQLAEQERRREQERLQAERE 736
           QE + QE+ E+ RR++E+   ++ R R+QE    E +
Sbjct: 625 QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 661



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 97/425 (22%), Positives = 187/425 (44%), Gaps = 40/425 (9%)

Query: 377 EPPEEAEPVAAAEPEVPENNGNNSWPHNDTE--IANSTPNPKPAASSPETPSAGQQEAKT 434
           +P     P     P +P +    + PH  T   +      P     S ET  +   EAK 
Sbjct: 6   QPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPMMSKETRQSKLAEAKE 65

Query: 435 DQADGPRE--PPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPL 492
              D   +  P        + K+ ++     +         P  +  +S      + R L
Sbjct: 66  QLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQKASHQHQEALRREL 125

Query: 493 RTFLHTV-----QRNQMLMTPTSAPRSVMK-SFIKRNTPLRMDPKCSFVEKERQRLENLR 546
              +HT+     Q+ ++ M    +  +V +     R+   R+     F  +  Q L  + 
Sbjct: 126 EAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVA 185

Query: 547 -RKEEAEQLRRQKVEEDKRRRLEEVK--LKREERLRKVLQARERVEQMKEEKKKQIEQKF 603
            +K++A++   +  +E     LE  +  +  EE   K  + +E++ Q+ E +K +I+   
Sbjct: 186 TQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKL-QLVESEKSEIQLNV 244

Query: 604 AQIDEKTEKAKEERLAEE-KAKKKAAAKKMEEVEARRKQEEEARRLRW----LQQEEEER 658
            ++  K E+AK     ++ +A+     K+++ V A+ + + E   L W     QQEE+  
Sbjct: 245 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENEL-WNRLNQQQEEKMW 303

Query: 659 RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQ 718
           R +E +Q+ +E+ QE+                   E++ REQE + +E+ E+ RR++E  
Sbjct: 304 RQEEKIQEWEEKIQEQ-------------------EEKIREQEEKIREQEEKMRRQEEMM 344

Query: 719 LAEQERRREQERLQAERELQERE-KALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQE 777
             ++E+ R QE +  E+E + R  + +  +KE+  RELEEK  ++E+ R  E + QEE++
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 404

Query: 778 KKAKE 782
            + +E
Sbjct: 405 IREQE 409



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 49/146 (33%), Positives = 86/146 (58%), Gaps = 11/146 (7%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
           EK R++ E +R +EE  Q + +K+ E + +  E+ K++R+E      + RE+ E+++E+K
Sbjct: 530 EKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEE-----KIREQEEKIREQK 584

Query: 596 KKQIEQKFAQIDEKTEKAK--EERLAEEKAKKKAAAKKM-EEVEARRKQEEEARRLRWLQ 652
           +K  EQ+  +I E+ EK +  EE + E++ K     +KM E+ E  ++QEE+ RR     
Sbjct: 585 EKIREQE-EKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM 643

Query: 653 QEEEERRHQELLQKKKEEEQERLRKA 678
            E+E R  Q+  ++K +E QE L  A
Sbjct: 644 WEQEVRLRQQ--EEKMQEHQEHLEAA 667


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score =  130 bits (328), Expect = 4e-30
 Identities = 87/263 (33%), Positives = 168/263 (63%), Gaps = 25/263 (9%)

Query: 536 EKERQRLENLRRKEEA-----EQLRRQKV----EEDKRRRLEEVKLKREERLRKVLQARE 586
           EK R++ E +RR+EE      E++RRQ+     +E+K R LEE K+  +E++R+  + R+
Sbjct: 309 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE-KMHEQEKIREQEEKRQ 367

Query: 587 RVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEAR 646
             E+++E++K+Q ++      E+  + +EE++ E++   +   +KM E E +  ++EE  
Sbjct: 368 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEM 427

Query: 647 RLRWLQQEEEERRHQELL---QKKKEEEQERLRKAAEAKRLAEQR--EQERR--EQERRE 699
           +    +QEE+ RR +E +   +KK  E++E++R+  E  +  E++  EQE +  EQE + 
Sbjct: 428 Q----EQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKM 483

Query: 700 QERREQERREQER-REQERQLAEQERR-REQERLQAERE--LQEREKALRLQKEQLQREL 755
           QE+ E+ RR++E+ REQE+++ EQE + REQE +  E+E  + E+E+ +  Q+E++Q + 
Sbjct: 484 QEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 543

Query: 756 EEKKKKEEQQRLAERQLQEEQEK 778
           E+ +++EE+ R  E +L++++EK
Sbjct: 544 EKMRRQEEKMREQEVRLRQQEEK 566



 Score =  127 bits (320), Expect = 4e-29
 Identities = 81/249 (32%), Positives = 160/249 (64%), Gaps = 18/249 (7%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERLRKVLQARERVEQMKE 593
           EK  ++ E ++ +EE  Q + +K+  +E+K RR EE+  ++EE++R+    +E +   KE
Sbjct: 288 EKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRR----QEEMMWEKE 343

Query: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ 653
           EK +++E+K  +  EK  + +E+R  EEK +++   +K +E EA+  ++EE  R    +Q
Sbjct: 344 EKIRELEEKMHE-QEKIREQEEKRQEEEKIREQ---EKRQEQEAKMWRQEEKIR----EQ 395

Query: 654 EEEERRHQELLQKKKEEEQERLRKAAEAKR-LAEQREQERREQER-REQERREQERREQE 711
           EE+ R  +E++Q+++E+  E+  K  E +  + EQ E+ RR++E+ REQE++ +E+ E+ 
Sbjct: 396 EEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKI 455

Query: 712 RREQERQLAEQERRREQERLQAERE--LQEREKALRLQKEQLQRELEEKKKKEEQQRLAE 769
           R ++E    ++E+  EQE    E+E  +QE+E+ +R Q+E+++ + ++ +++EE+ R  E
Sbjct: 456 REQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE 515

Query: 770 RQLQEEQEK 778
             +QE++EK
Sbjct: 516 EMMQEQEEK 524



 Score =  117 bits (292), Expect = 6e-26
 Identities = 78/271 (28%), Positives = 157/271 (57%), Gaps = 29/271 (10%)

Query: 543 ENLRRKEEAEQLRRQKVEEDKRR-RLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQ 601
           E L+ K    Q + Q VE +K   +L   +LKR+    K+L  +++++   +   K+++ 
Sbjct: 205 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 264

Query: 602 KFAQIDEKTEK---------AKEERLAEEKAKKKAAAKKMEEVEAR-RKQEEEARRLRWL 651
             A++  + E+          +EE++  ++ K +   +K++E E + R+QEE+ RR   +
Sbjct: 265 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEM 324

Query: 652 QQEEEE--RRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQE--- 706
             E+EE  RR +E++ +K+E+ +E   K  E +++ EQ E+ + E++ REQE+R+++   
Sbjct: 325 MWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK 384

Query: 707 --RREQERREQERQLAEQER----------RREQERLQAERELQEREKALRLQKEQLQRE 754
             R+E++ REQE ++ EQE            +E++  + E E+QE+E+ +R Q+E++ RE
Sbjct: 385 MWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKI-RE 443

Query: 755 LEEKKKKEEQQRLAERQLQEEQEKKAKEAAG 785
            E+K +++E++   + ++ +EQE+K  E  G
Sbjct: 444 QEKKIREQEEKIREQEEMMQEQEEKMGEQEG 474



 Score =  105 bits (262), Expect = 2e-22
 Identities = 65/232 (28%), Positives = 136/232 (58%), Gaps = 14/232 (6%)

Query: 529 DPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERV 588
           + K   +E++    E +R +EE  Q   +K+ E ++R+ +E K+ R+E   K+ +  E++
Sbjct: 343 EEKIRELEEKMHEQEKIREQEEKRQ-EEEKIREQEKRQEQEAKMWRQEE--KIREQEEKI 399

Query: 589 EQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 648
            + +E  ++Q E+K  + +EK  + +EE   +E+  ++   K  E+ +  R+QEE+ R  
Sbjct: 400 REQEEMMQEQ-EEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ 458

Query: 649 RWLQQEEEERRHQEL-----LQKKKEEEQERLRKAAEAKRLAEQREQERREQER-REQER 702
             + QE+EE+  ++       + K +E++E++R+  E  ++ EQ ++ R ++E+ REQE 
Sbjct: 459 EEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEE--KIREQEKKIREQEEKIREQEE 516

Query: 703 REQERREQERREQERQLAEQERRREQER--LQAERELQEREKALRLQKEQLQ 752
             QE+ E+   ++E+   ++E+ +EQE    + E +++E+E  LR Q+E++Q
Sbjct: 517 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568



 Score = 94.0 bits (232), Expect = 6e-19
 Identities = 59/250 (23%), Positives = 137/250 (54%), Gaps = 7/250 (2%)

Query: 536 EKERQRLENLRRKEEAEQLR--RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKE 593
           +K  + +E L ++ +A  L   R  + +++   L+E   K +E+L+ V   +  ++   +
Sbjct: 177 KKADRYIEELTKERDALSLELYRNTITDEE---LKEKNAKLQEKLQLVESEKSEIQLNVK 233

Query: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK-KMEEVEARRKQEEEARRLRWLQ 652
           E K+++E+    + ++  +A+ + L +E     A  + ++EE E   +  ++     W Q
Sbjct: 234 ELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ 293

Query: 653 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 712
           +E+ + R +E +Q+++E+ +E+  K    + +  ++E++ R QE    E+ E+ R  +E+
Sbjct: 294 EEKIQER-EEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 352

Query: 713 REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQL 772
             ++ ++ EQE +R++E    E+E ++ ++A   ++E+  RE EEK +++E+    + + 
Sbjct: 353 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEK 412

Query: 773 QEEQEKKAKE 782
             EQE+K  E
Sbjct: 413 MGEQEEKMWE 422



 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 57/188 (30%), Positives = 111/188 (59%), Gaps = 15/188 (7%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
           EK R++ E +R +EE  Q + +K+ E + +  E+     EE +++  +   R E+   E+
Sbjct: 390 EKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQ-----EEEMQEQEEKMRRQEEKIREQ 444

Query: 596 KKQIEQKFAQIDEKTE--KAKEERLAEEKAKK-KAAAKKMEEVEARRKQEEEARRL--RW 650
           +K+I ++  +I E+ E  + +EE++ E++ K  +  AK  E+ E  R+QEE+ R    + 
Sbjct: 445 EKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKI 504

Query: 651 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQE--RR 708
            +QEE+ R  +E++Q+++E+  E+  K  E +   +++E++ R   R+E++ REQE   R
Sbjct: 505 REQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR---RQEEKMREQEVRLR 561

Query: 709 EQERREQE 716
           +QE + QE
Sbjct: 562 QQEEKMQE 569



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 60/269 (22%), Positives = 130/269 (48%), Gaps = 30/269 (11%)

Query: 540 QRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVL-QARERVEQMKEEKKKQ 598
           Q  E LRR+ EA Q++  ++   ++  L+      +  ++++  +AR+ + ++ +  K  
Sbjct: 104 QHQEALRRELEA-QVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFA 162

Query: 599 IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK------KMEEVEARRKQEEEARRLRWLQ 652
            E + A     T+K K +R  EE  K++ A         + + E + K  +   +L+ ++
Sbjct: 163 GELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVE 222

Query: 653 QEEEE-------------RRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE 699
            E+ E             R    L Q++ + E + L K  ++     Q + E  E   R 
Sbjct: 223 SEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL 282

Query: 700 QERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELE--- 756
            +++E++   QE + QER   E++ + ++E+++ + E   R++ +  +KE+  R  E   
Sbjct: 283 NQQQEEKMWRQEEKIQER---EEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM 339

Query: 757 ---EKKKKEEQQRLAERQLQEEQEKKAKE 782
              E+K +E ++++ E++   EQE+K +E
Sbjct: 340 WEKEEKIRELEEKMHEQEKIREQEEKRQE 368



 Score = 53.5 bits (127), Expect = 9e-07
 Identities = 41/146 (28%), Positives = 82/146 (56%), Gaps = 21/146 (14%)

Query: 536 EKERQRLENLRRKEEA--EQLRRQKVEEDKRRRLEEVKLKREERLRKV----------LQ 583
           E+ +++ E +RR+EE   EQ ++ + +E+K R  EE+  ++EE++ +           +Q
Sbjct: 425 EEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQ 484

Query: 584 ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE------ERLAEEKAKKKAAAKKMEEVEA 637
            +E   + +EEK ++ E+K  + +EK  + +E      E++ E++ K     +KM+E E 
Sbjct: 485 EQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 544

Query: 638 --RRKQEE-EARRLRWLQQEEEERRH 660
             RR++E+   + +R  QQEE+ + H
Sbjct: 545 KMRRQEEKMREQEVRLRQQEEKMQEH 570


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score =  128 bits (321), Expect = 3e-29
 Identities = 87/277 (31%), Positives = 161/277 (58%), Gaps = 33/277 (11%)

Query: 536 EKERQRLENLRRKEEA--EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKE 593
           EK R++ E + R+EE   EQ ++ + +E K R  EE   +++ERLR+  +     E+M E
Sbjct: 362 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE 421

Query: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR---W 650
           + +K  E+K  Q  EK  + +EE++ EE+  ++   K  EE E  R+QEE+ ++     W
Sbjct: 422 QVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMW 481

Query: 651 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER--------REQER 702
            Q+E+E ++ +   QK+K  EQE++++  E  ++ EQ E+ R ++E         R+++ 
Sbjct: 482 EQEEKEWQQQRLPEQKEKLWEQEKMQEQEE--KIWEQEEKIRDQEEMWGQEKKMWRQEKM 539

Query: 703 REQE----RREQERREQERQLAEQERRRE-------------QERLQAERELQEREKALR 745
           REQE     +E++ R+QE+++ +QE R E             +E+++ E  ++EREK +R
Sbjct: 540 REQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMR 599

Query: 746 LQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
            ++E++ RE EEK +++E++   + +   EQE+K +E
Sbjct: 600 -EEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQE 635



 Score =  125 bits (313), Expect = 2e-28
 Identities = 82/268 (30%), Positives = 162/268 (60%), Gaps = 22/268 (8%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERL-RKVLQARERVEQMK 592
           EKE +  + LR +EE  Q + +K+  +E+K R  EE   ++EERL  +  Q RE+ ++M+
Sbjct: 334 EKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMR 393

Query: 593 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA------- 645
           +++++  EQ   ++ EK E+ +E+    E+ +K    KKM+E E + + +EE        
Sbjct: 394 DQEERMWEQD-ERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERI 452

Query: 646 -RRLRWLQQEEEERRHQ-ELLQKKKEEEQERLRKAAEAKRLAEQRE-----QERREQERR 698
             R + +++EEE  R Q E +QK++E   E+  K  + +RL EQ+E     ++ +EQE +
Sbjct: 453 REREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 512

Query: 699 EQERREQERREQERREQERQLAEQERRREQE--RLQAERELQEREKALRLQKEQLQRELE 756
             E+ E+ R ++E   QE+++  QE+ REQE    + E +++++E+ +  Q+E+++++ +
Sbjct: 513 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQ 572

Query: 757 EKKKK--EEQQRLAERQLQEEQEKKAKE 782
           E++KK  ++++++ E +   E+EKK +E
Sbjct: 573 EQEKKTWDQEEKMREEERMREREKKMRE 600



 Score =  120 bits (302), Expect = 4e-27
 Identities = 100/437 (22%), Positives = 216/437 (49%), Gaps = 40/437 (9%)

Query: 369 QKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAG 428
           QK   EQ+E  +E E     + E         W   +          +      E     
Sbjct: 340 QKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEER-----LWEQEKQMREQEQKMRD 394

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEEL----QPPRSKTPSSPCP 484
           Q+E   +Q +  RE  +  R +    + V ++ EE+ ++++E     Q  + +       
Sbjct: 395 QEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRE 454

Query: 485 ASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLEN 544
             K +R     +   Q  +M     +      K + ++  P   + K    E+E+ + + 
Sbjct: 455 REKKMREEEETMRE-QEEKMQKQEENMWEQEEKEWQQQRLP---EQKEKLWEQEKMQEQE 510

Query: 545 LRRKEEAEQLRRQKV---------EEDKRRRLEEVKLKREERLR----KVLQARERVEQM 591
            +  E+ E++R Q+           ++K R  E+   ++EE++R    K+    ER+E+ 
Sbjct: 511 EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKK 570

Query: 592 -KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 650
            +E++KK  +Q+    +E+  + +E+++ EE+   +   +KM+E E + +++EE    + 
Sbjct: 571 TQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE----KM 626

Query: 651 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE--------QERREQERREQER 702
            +QEE+ +  +E + +++E+  E+  K  E +RL EQ+E        QE+ + + +E++ 
Sbjct: 627 WEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKI 686

Query: 703 REQERREQERREQERQLAEQERRREQERL-QAERELQEREKALRLQKEQLQRELEEKKKK 761
            EQE+ E++ +EQE++  +QE+ RE+E + + E++++E E+ +R Q+E++Q + E+ +++
Sbjct: 687 WEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 746

Query: 762 EEQQRLAERQLQEEQEK 778
           EE+    E ++ E++EK
Sbjct: 747 EEEMWEQEEKMWEQEEK 763



 Score =  118 bits (296), Expect = 2e-26
 Identities = 95/343 (27%), Positives = 191/343 (55%), Gaps = 35/343 (10%)

Query: 461 DEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFI 520
           +EE   ++ ELQ    K P +    S++   ++     ++R + L+ P     ++ +   
Sbjct: 220 NEELKKKNAELQ---EKLPLAESEKSEIQLNVKELKRKLERAKFLL-PQVQTNTLQEEMW 275

Query: 521 KRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVE---EDKRRRLEEVKLKREER 577
           ++   LR   K    ++E+   +  R +E+  ++R Q+ +   ++KR R +E +L+ +E+
Sbjct: 276 RQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEK 335

Query: 578 -LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKA--KEERLAEEKAKKKAAAKKMEE 634
            LR+  + RE+ EQM+E+++K  EQ+  ++ E+ EK   +EERL E++ + +   +KM +
Sbjct: 336 ELREQKELREQEEQMQEQEEKMWEQE-EKMREQEEKMWRQEERLWEQEKQMREQEQKMRD 394

Query: 635 VEARRKQEEEARRLRWLQQEEEERRHQE--------LLQKKKEEEQERLRKAAEAKRLAE 686
            E R  +++E      L+++EE  R QE        + ++KK +EQE+  +  E K   E
Sbjct: 395 QEERMWEQDER-----LREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEE 449

Query: 687 QREQERREQERREQE-RREQERREQERRE-----QERQLAEQERRREQERLQAERELQER 740
           +R +ER ++ R E+E  REQE + Q++ E     +E++  +Q    ++E+L  + ++QE+
Sbjct: 450 ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 509

Query: 741 EKALRLQKEQL--QREL---EEKKKKEEQQRLAERQLQEEQEK 778
           E+ +  Q+E++  Q E+   E+K  ++E+ R  E Q+ E++EK
Sbjct: 510 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 552



 Score =  117 bits (294), Expect = 4e-26
 Identities = 76/262 (29%), Positives = 161/262 (61%), Gaps = 15/262 (5%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERLR-KVLQARERVEQMK 592
           EKE +  E  +  E+ E++R +K   E++K+ R +E K++ EER+R +  + RE  E M+
Sbjct: 408 EKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMR 467

Query: 593 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 652
           E+++K  +Q+    +++ ++ +++RL E+K K     K  E+ E   +QEE+ R    + 
Sbjct: 468 EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 527

Query: 653 QEEEERRHQELLQKKKE---EEQERLRKAAEAKRLAEQR-EQERREQERREQERREQERR 708
            +E++   QE ++++++   E++E++R   +     E+R E++ +EQE++  ++ E+ R 
Sbjct: 528 GQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMRE 587

Query: 709 EQERREQERQLAEQER--RREQERLQAERE-LQEREKALRLQKEQLQRELE-----EKKK 760
           E+  RE+E+++ E+E   R ++E++Q + E +QE+E+ +  Q+E++Q + E     E+K 
Sbjct: 588 EERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKM 647

Query: 761 KEEQQRLAERQLQEEQEKKAKE 782
            E+++++ E+Q   EQ++K  E
Sbjct: 648 WEQEEKMWEQQRLPEQKEKLWE 669



 Score =  114 bits (286), Expect = 3e-25
 Identities = 79/267 (29%), Positives = 159/267 (59%), Gaps = 17/267 (6%)

Query: 527 RMDPKCSFVEKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERLRKVLQA 584
           RM+ K    EK+    E   R+EE  + R +K+  EE+  R  EE   ++EE++++  + 
Sbjct: 566 RMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEK 625

Query: 585 R-ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 643
             E+ E+M+E+++K  EQ+    +++ +  +++RL E+K +K    +KM+E E  ++QEE
Sbjct: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQK-EKLWEHEKMQEQEKMQEQEE 684

Query: 644 ---EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQ 700
              E  ++    QE+E++   +   +++E  +ER +K  E + +  ++E++ +EQE + Q
Sbjct: 685 KIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQ 744

Query: 701 ERREQERREQERR--EQERQLAEQERRREQ-------ERLQAERELQEREKALRLQKEQL 751
           E +E+E  EQE +  EQE ++ EQ+R  EQ       E++Q + ++ E+E+ +R Q+E++
Sbjct: 745 E-QEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKM 803

Query: 752 QRELEEKKKKEEQQRLAERQLQEEQEK 778
           + + E+ + +EE+ R  E ++  ++EK
Sbjct: 804 RGQEEKMRGQEEKMRGQEEKMWGQEEK 830



 Score =  112 bits (279), Expect = 2e-24
 Identities = 76/273 (27%), Positives = 162/273 (59%), Gaps = 21/273 (7%)

Query: 522 RNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKV 581
           R   +R      + ++E+ R +  +  ++ E++ ++  E++K+   +E K++ EER+R+ 
Sbjct: 535 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRE- 593

Query: 582 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ 641
              RE+  + +EE  ++ E+K  + +EK ++ +EE++ E++ K +   +KM E E +  +
Sbjct: 594 ---REKKMREEEEMMREQEEKMQEQEEKMQE-QEEKMWEQEEKMQEQEEKMWEQEEKMWE 649

Query: 642 EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR--- 698
           +EE     W QQ   E++ ++L + +K +EQE++++  E     E+ E++ +EQE++   
Sbjct: 650 QEEK---MWEQQRLPEQK-EKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWD 705

Query: 699 -EQERREQERREQER--REQERQLAEQERR---REQERLQAERELQEREKALRLQKEQL- 751
            E+ R E+  RE+E+  RE+E  + EQE +   +E++  + E E+ E+E+ +  Q+E++ 
Sbjct: 706 QEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMW 765

Query: 752 --QRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
             QR  E+K+K  E +++ E++   EQE+K ++
Sbjct: 766 EQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRD 798



 Score =  109 bits (273), Expect = 1e-23
 Identities = 86/279 (30%), Positives = 164/279 (58%), Gaps = 39/279 (13%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRL-----EEVKLKREERLRKVLQARERVEQ 590
           E++   LE  R     E+L+++  E  ++  L      E++L  +E  RK+ +A+  + Q
Sbjct: 205 ERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQ 264

Query: 591 MK-----------EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARR 639
           ++           EE+ ++ E+K  + +EK  + +EERL E++ K +   +KM   E R 
Sbjct: 265 VQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR-QEERLREQEGKMREQEEKMWRQEKRL 323

Query: 640 KQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAK-RLAEQREQERREQER- 697
           +++E+      L+++E+E R Q+ L++++E+ QE+  K  E + ++ EQ E+  R++ER 
Sbjct: 324 REQEKE-----LREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERL 378

Query: 698 --REQERREQER--REQERR--EQERQLAE-QERRREQ-------ERLQAERELQEREKA 743
             +E++ REQE+  R+QE R  EQ+ +L E +ER REQ       E+++ E+++QE+EK 
Sbjct: 379 WEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKK 438

Query: 744 LRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
            R Q+E++Q E E  +++E++ R  E  ++E++EK  K+
Sbjct: 439 TRDQEEKMQEE-ERIREREKKMREEEETMREQEEKMQKQ 476



 Score =  104 bits (259), Expect = 4e-22
 Identities = 103/489 (21%), Positives = 227/489 (46%), Gaps = 39/489 (7%)

Query: 318 LAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKE 377
           L +K   + +QE +  +  +   +K  +E     R       ++   ++  +++   +K+
Sbjct: 406 LREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR-------DQEEKMQEEERIREREKK 458

Query: 378 PPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQA 437
             EE E +   E ++ +    N W   + E        +      +     Q+E   +Q 
Sbjct: 459 MREEEETMREQEEKMQKQE-ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE 517

Query: 438 DGPREPPQS-ARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFL 496
           +  R+  +   + K+ ++Q      E+Q  E EE    R +         ++ +  +   
Sbjct: 518 EKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKM--RDQEQKMWDQEERMEKKTQEQE 575

Query: 497 HTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEA--EQL 554
                 +  M      R   K   +    +R        EK +++ E ++ +EE   EQ 
Sbjct: 576 KKTWDQEEKMREEERMREREKKMREEEEMMREQE-----EKMQEQEEKMQEQEEKMWEQE 630

Query: 555 RRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKT-EKA 613
            + + +E+K    EE   ++EE++ +  +  E+ E++ E +K Q ++K  + +EK  E+ 
Sbjct: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQE 690

Query: 614 KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ- 672
           K E+  +E+ KK    +KM E E+ R++E++ R    + +E+EE+  ++  + +++EE+ 
Sbjct: 691 KMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEM 750

Query: 673 --------ERLRKAAEAKRLAEQREQERREQERREQER---REQERREQE---RREQERQ 718
                   E+  K  E +RL EQ+E+    ++ +EQE+   +E++ R+QE   R ++E+ 
Sbjct: 751 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKM 810

Query: 719 LAEQERRREQERLQ--AERELQEREKALRLQKEQL---QRELEEKKKKEEQQRLAERQLQ 773
             ++E+ R QE      E ++  +E+ +  Q+E++   + ++EEK + +E++   + +  
Sbjct: 811 RGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKM 870

Query: 774 EEQEKKAKE 782
             QE+K +E
Sbjct: 871 RGQEEKMRE 879



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 74/351 (21%), Positives = 174/351 (49%), Gaps = 14/351 (3%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
           +QE K    +      +    K++ +Q     D+E+ + +EE    R K         + 
Sbjct: 548 EQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKK------MREE 601

Query: 489 VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRK 548
              +R     +Q  +  M          +  ++       + +    E+E +  E  R  
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661

Query: 549 EEAEQL-RRQKVEEDKRRRLEEVKLKREERLRKVLQARERV----EQMKEEKKKQIEQKF 603
           E+ E+L   +K++E ++ + +E K+  +E++ K  Q +E+     E+M+EE+  +  +K 
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKK 721

Query: 604 AQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA--RRLRWLQQEEEERRHQ 661
            + +E+  + +EE++ E++ K +   ++M E E +  ++EE    + R  +Q+E+   H+
Sbjct: 722 MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 781

Query: 662 ELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAE 721
           ++ +++K  EQE   +  E K   ++ +   +E++ R QE +   + E+   ++E+   +
Sbjct: 782 KMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ 841

Query: 722 QERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQL 772
           +E+   QE  + E ++Q +E+ +R Q+E+++ + E+ +++EE+ R  E ++
Sbjct: 842 EEKMWGQEE-KMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 54/181 (29%), Positives = 98/181 (54%), Gaps = 11/181 (6%)

Query: 610 TEKAKEERLAEEKAKKKAAAK------KMEEVEARRKQEEEARRLRWLQQEEEERRHQEL 663
           T   K +R  EE  K++ A         +   E ++K  E   +L   + E+ E +    
Sbjct: 190 TRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVK 249

Query: 664 LQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQE 723
             K+K E  + L    +   L  Q E  R+E+E REQE++ +++ E+  R++ER   ++ 
Sbjct: 250 ELKRKLERAKFLLPQVQTNTL--QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEG 307

Query: 724 RRREQERL--QAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 781
           + REQE    + E+ L+E+EK LR Q+++L RE +E +++EEQ +  E ++ E++EK  +
Sbjct: 308 KMREQEEKMWRQEKRLREQEKELREQEKEL-REQKELREQEEQMQEQEEKMWEQEEKMRE 366

Query: 782 E 782
           +
Sbjct: 367 Q 367


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score =  127 bits (320), Expect = 4e-29
 Identities = 93/287 (32%), Positives = 169/287 (58%), Gaps = 44/287 (15%)

Query: 536 EKERQRLENLRRKEEA-----EQLRRQKV----EEDKRRRLEEVKLKREERLRKVLQARE 586
           EK R++ E +RR+EE      E++RRQ+     +E+K RR EE+  ++EE++R+    +E
Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR----QE 383

Query: 587 RVEQMKEEKKKQIEQKFAQ---IDEKTEKAKEE-RLAEEKAKKKAAAKKMEEVEARRKQE 642
            +   KEEK +++E+K  +   I E+ EK +EE ++ E++ +++  AK   + E  R+QE
Sbjct: 384 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 443

Query: 643 EEAR---RLRWLQQE----------EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE 689
           E+ R   +  W Q+E          EE+R+ QE + +++E+  E+     + +++ EQ E
Sbjct: 444 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEE 503

Query: 690 QERREQER--------REQER--REQE----RREQERREQERQLAEQERRREQERLQAER 735
           + R+++E+        REQE   REQE    R+E++ REQE    E+E+  EQE++  E 
Sbjct: 504 KIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEE 563

Query: 736 ELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
           + QE+E  +  Q+E+++ + E+  ++EE+ R  E + QE++EK  K+
Sbjct: 564 KRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610



 Score =  122 bits (307), Expect = 1e-27
 Identities = 78/256 (30%), Positives = 160/256 (62%), Gaps = 18/256 (7%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERLRKVLQARERVEQMKE 593
           EK  ++ E +R++EE    + +K+  +E+K R  EE   ++EE++R+  +     E+M E
Sbjct: 496 EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHE 555

Query: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ 653
           ++K   E+K  + ++K  + +EE++ E++ K     +K+ E E +R+++EE    +  +Q
Sbjct: 556 QEKIWEEEKRQEQEDKMWR-QEEKIREQEEKVWRQEEKIREQEEKRQEQEE----KMWKQ 610

Query: 654 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR--EQERREQE----- 706
           EE+ R  +E +Q+++E+ +E+  K  E + + +++E++  EQE +  EQE + QE     
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM 670

Query: 707 -RREQERREQERQLAEQERR-REQERLQAERE--LQEREKALRLQKEQLQRELEEKKKKE 762
            R+E++ REQE+++ EQE + REQE +  E+E  + E+E+ +  Q+E++Q + E+ +++E
Sbjct: 671 WRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 730

Query: 763 EQQRLAERQLQEEQEK 778
           E+    E +L++++EK
Sbjct: 731 EKMWEQEVRLRQQEEK 746



 Score =  116 bits (291), Expect = 8e-26
 Identities = 89/316 (28%), Positives = 176/316 (55%), Gaps = 59/316 (18%)

Query: 526 LRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKV----EEDKRRRLEEVKLKREERLRKV 581
           +R   +  + ++E+ R +     E+ E++RRQ+     +E+K RR EE+  ++EE++R++
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL 396

Query: 582 LQARERVEQMKE-EKKKQIEQKFAQIDEKTEKA-----KEERLAEEKAKKKAAAKKM--- 632
            +     E+++E E+K+Q E+K  + +++ E+      +EE++ E++ K +   KKM   
Sbjct: 397 EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ 456

Query: 633 ----------EEVEARRKQEEEARRLR--------WLQ------QEEEERRHQELLQKKK 668
                      E E R++QEE  R+          W Q      QEE+ R+ +E + +++
Sbjct: 457 EEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQE 516

Query: 669 E---EEQERLRKAAE-----AKRLAEQREQERREQERREQE-------RREQE----RRE 709
           E   E++E++R+  E      +++ EQ E  R E++  EQE       R+EQE    R+E
Sbjct: 517 EKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQE 576

Query: 710 QERREQERQLAEQE---RRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQR 766
           ++ REQE ++  QE   R +E++R + E ++ ++E+ +R Q+E++Q + E+ +++EE+ R
Sbjct: 577 EKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIR 636

Query: 767 LAERQLQEEQEKKAKE 782
             E   QE++EK  ++
Sbjct: 637 EQEEMTQEQEEKMGEQ 652



 Score =  115 bits (289), Expect = 1e-25
 Identities = 79/262 (30%), Positives = 160/262 (61%), Gaps = 16/262 (6%)

Query: 536 EKERQRLENLRRKEEA----EQLRRQKV----EEDKRRRLEEVKLKREERLRKVLQA-RE 586
           E++RQ  E + R+EE     E++ RQK     +E+K R+ EE   ++EE++R+  +  RE
Sbjct: 469 EEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528

Query: 587 RVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEAR 646
           + E+M  +++K  EQ+    +E+ +  ++E++ EE+ +++   K   + E  R+QEE+  
Sbjct: 529 QEEKMWRQEEKIREQEEMWREEE-KMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVW 587

Query: 647 RLRWLQQEEEERRHQ--ELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 704
           R     +E+EE+R +  E + K++E+ +E+  K  E +    ++E++ REQE   QE+ E
Sbjct: 588 RQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEE 647

Query: 705 QERREQERR-EQERQLAEQER---RREQERLQAERELQEREKALRLQKEQLQRELEEKKK 760
           +   ++E+  EQE ++ EQE    R+E++  + E++++E+E+ +R Q+E +Q + E+  +
Sbjct: 648 KMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 707

Query: 761 KEEQQRLAERQLQEEQEKKAKE 782
           +EE+    E ++QE++EK  ++
Sbjct: 708 QEEKMCEQEEKMQEQEEKMRRQ 729



 Score =  114 bits (284), Expect = 5e-25
 Identities = 77/260 (29%), Positives = 154/260 (59%), Gaps = 23/260 (8%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
           EK R++ E +R +E+    + +K+ E ++ R EE + ++EE  R+  +  E+ E++  +K
Sbjct: 437 EKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQ-EEIWRQK 495

Query: 596 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 655
           +K  EQ     +EK  K +E+   +E+  ++   K  E+ E   +QEE+ R    + +EE
Sbjct: 496 EKMHEQ-----EEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREE 550

Query: 656 EERRHQELL--QKKKEEEQERLRKAAEAKRLAEQR----EQERREQERREQERREQERRE 709
           E+   QE +  ++K++E+++++ +  E  R  E++    E++ REQE + QE+ E+  ++
Sbjct: 551 EKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610

Query: 710 QER-REQERQLAEQERR--------REQERLQAERE--LQEREKALRLQKEQLQRELEEK 758
           +E+ REQE ++ EQE +        REQE +  E+E  + E+E+ +  Q+E++Q + E  
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM 670

Query: 759 KKKEEQQRLAERQLQEEQEK 778
            ++EE+ R  E++++E++EK
Sbjct: 671 WRQEEKIREQEKKIREQEEK 690



 Score =  113 bits (282), Expect = 9e-25
 Identities = 82/264 (31%), Positives = 159/264 (60%), Gaps = 33/264 (12%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKV----EEDKRRRLEEVKLKREERLRKVLQARERVEQM 591
           EK R++ E +R +EE  ++RRQ+     +E+K RR EE+  ++EE++R+    +E +   
Sbjct: 321 EKIREQEEKIREQEE--KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR----QEEMMWE 374

Query: 592 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV--EARRKQEEEARRLR 649
           KEEK ++ E+   + +EK  + +E+   +EK +++   ++ EE   E  ++QE+EA+  R
Sbjct: 375 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 434

Query: 650 WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE 709
               +EE+ R QE  +K +E+E++  R+  +     + RE+E+R QE+ E  R+E++  E
Sbjct: 435 ----QEEKIREQE--EKIREQEKKMWRQEEKIHEQEKIREEEKR-QEQEEMWRQEEKIHE 487

Query: 710 QER--REQERQLAEQERRREQER--LQAERELQEREKALRLQKEQLQRELE--------- 756
           QE   R++E+   ++E+ R+QE    + E +++E+E+ +R Q+E++ R+ E         
Sbjct: 488 QEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMW 547

Query: 757 -EKKKKEEQQRLAERQLQEEQEKK 779
            E++K  EQ+++ E + ++EQE K
Sbjct: 548 REEEKMHEQEKIWEEEKRQEQEDK 571



 Score =  111 bits (278), Expect = 3e-24
 Identities = 69/237 (29%), Positives = 147/237 (62%), Gaps = 14/237 (5%)

Query: 553 QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEK 612
           +L+ Q  E +   RL + + ++  R  + +Q  E   Q +EEK ++ E+K  + +EK  +
Sbjct: 280 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 339

Query: 613 AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ 672
            +EE + E++ K +   + M E E + +++EE   + W ++EE+ RR +E++ +K+E+ +
Sbjct: 340 -QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE---MMW-EKEEKMRRQEEMMWEKEEKIR 394

Query: 673 ERLRKAAEAKRLAEQREQERREQERREQERREQE-----RREQERREQERQLAEQERR-- 725
           E   K  E +++ EQ E+ + E++ REQE+R+++     R+E++ REQE ++ EQE++  
Sbjct: 395 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMW 454

Query: 726 REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
           R++E++  + +++E EK  R ++E++ R+ E+  ++EE  R  E+  ++E++ + +E
Sbjct: 455 RQEEKIHEQEKIREEEK--RQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQE 509



 Score =  111 bits (277), Expect = 4e-24
 Identities = 80/278 (28%), Positives = 167/278 (60%), Gaps = 25/278 (8%)

Query: 529 DPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKL-KREERLRKVLQA-RE 586
           + K   +E++    E +R +EE  Q   +K+ E ++R+ +E K+ ++EE++R+  +  RE
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQ-EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 448

Query: 587 RVEQMKEEKKKQIEQKFAQIDEKTEKAKE-----ERLAEEKAKKKAAAKKMEEVEARRKQ 641
           + ++M  +++K  EQ+  + +EK ++ +E     E++ E++   +   K  E+ E  RKQ
Sbjct: 449 QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQ 508

Query: 642 EEEARRL--RWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQR----EQERREQ 695
           EE+  R   +  +QEE+ R  +E + +++E+ +E+     E +++ EQ     E++R+EQ
Sbjct: 509 EEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQ 568

Query: 696 E----RREQERREQE----RREQERREQERQLAEQER---RREQERLQAERELQEREKAL 744
           E    R+E++ REQE    R+E++ REQE +  EQE    ++E++  + E ++QE+E+ +
Sbjct: 569 EDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKI 628

Query: 745 RLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
           R Q+E+++ + E  +++EE+    E ++ E++EK  ++
Sbjct: 629 REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ 666



 Score =  111 bits (277), Expect = 4e-24
 Identities = 76/261 (29%), Positives = 161/261 (61%), Gaps = 21/261 (8%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERV---EQMK 592
           E++RQ  E +R +E+ ++   +   ++++ R +E K++ +E+  K+ +  E++   E+++
Sbjct: 410 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK--KMWRQEEKIHEQEKIR 467

Query: 593 EEKKKQIEQKFAQIDEKTEKAKE-----ERLAEEKAK-KKAAAKKMEEVEARRKQEEEAR 646
           EE+K+Q +++  + +EK  + +E     E++ E++ K +K   K   + E  R+QEE+ R
Sbjct: 468 EEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIR 527

Query: 647 RLRW-LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE---- 701
                + ++EE+ R QE + +++E+  E+ +   E KR  ++ +  R+E++ REQE    
Sbjct: 528 EQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVW 587

Query: 702 RREQERREQE--RREQERQLAEQER--RREQERLQAERE-LQEREKALRLQKEQLQRELE 756
           R+E++ REQE  R+EQE ++ +QE   R ++E++Q + E ++E+E+ +R Q+E  Q + E
Sbjct: 588 RQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEE 647

Query: 757 EKKKKEEQQRLAERQLQEEQE 777
           +  ++EE+    E ++QE++E
Sbjct: 648 KMGEQEEKMCEQEEKMQEQEE 668



 Score =  106 bits (264), Expect = 1e-22
 Identities = 72/247 (29%), Positives = 145/247 (58%), Gaps = 24/247 (9%)

Query: 539 RQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ 598
           +Q+ E + R+EE  Q   +K++E + +  E+     EE++R+  +   R E+M  EK+++
Sbjct: 296 QQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ-----EEKIREQEEKMRRQEEMMWEKEEK 350

Query: 599 IEQKFAQIDEKTEKAK--EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 656
           + ++   + EK EK +  EE + E++ K +   + M E      +EE+ R L     E+E
Sbjct: 351 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE------KEEKIRELEEKMHEQE 404

Query: 657 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER--REQER---REQE 711
           + R QE    +K +E+E++R+  + KR  ++ +  R+E++ REQE   REQE+   R++E
Sbjct: 405 KIREQE----EKRQEEEKIRE--QEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEE 458

Query: 712 RREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ 771
           +  ++ ++ E+E+R+EQE +  + E    ++ +  QKE++  + E+ +K+EE+    E +
Sbjct: 459 KIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEK 518

Query: 772 LQEEQEK 778
           ++E++EK
Sbjct: 519 IREQEEK 525



 Score =  100 bits (248), Expect = 8e-21
 Identities = 80/286 (27%), Positives = 154/286 (53%), Gaps = 33/286 (11%)

Query: 527 RMDPKCSFVEKERQRLE----NLRRKEEAEQL-----RRQKVEEDKRRRLEEVKLKREER 577
           ++  K   VE E+  ++     L+RK E  +L     + Q   +   + L+ V  K + +
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 284

Query: 578 LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA 637
           + +  +   R+ Q +EEK  + E+K  + +EK ++ +EE++ E++ K +   +KM   E 
Sbjct: 285 VEEN-ELWNRLNQQQEEKMWRQEEKIQEWEEKIQE-QEEKIREQEEKIREQEEKMRRQEE 342

Query: 638 RRKQEEEARR----LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR 693
              ++EE  R    + W ++EE+ RR +E++ +K+E+ + +     E +    + E++  
Sbjct: 343 MMWEKEEKMRRQEEMMW-EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH 401

Query: 694 EQER-REQERREQER---REQERRE--------QERQLAEQERR-REQER--LQAERELQ 738
           EQE+ REQE + QE    REQE+R+        QE ++ EQE + REQE+   + E ++ 
Sbjct: 402 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH 461

Query: 739 EREKALRLQKEQLQREL--EEKKKKEEQQRLAERQLQEEQEKKAKE 782
           E+EK    +K Q Q E+  +E+K  E+++   +++   EQE+K ++
Sbjct: 462 EQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRK 507



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 73/265 (27%), Positives = 152/265 (57%), Gaps = 33/265 (12%)

Query: 543 ENLRRKEEAEQLRRQKVEEDKRR-RLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQ 601
           E L+ K    Q + Q VE +K   +L   +LKR+    K+L  +++++   +   K+++ 
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 276

Query: 602 KFAQIDEKTEK----------------AKEERLAEEKAKKKAAAKKMEEVEAR-RKQEEE 644
             A++  + E+                 +EE++ E + K +   +K+ E E + R+QEE+
Sbjct: 277 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEK 336

Query: 645 ARR---LRWLQQEEEERRHQELLQKKKEE---EQERLRKAAEAKRLAEQREQERREQERR 698
            RR   + W ++EE+ RR +E++ +K+E+   ++E + +  E  R  E+   E+ E+ R 
Sbjct: 337 MRRQEEMMW-EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE 395

Query: 699 -EQERREQE--RREQERREQERQLAEQERRREQE--RLQAERELQEREKALRLQKEQLQR 753
            E++  EQE  R ++E+R++E ++ EQE+R+EQE    + E +++E+E+ +R Q++++ R
Sbjct: 396 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWR 455

Query: 754 ELEEKKKKEEQQRLAERQLQEEQEK 778
              +++K  EQ+++ E + ++EQE+
Sbjct: 456 ---QEEKIHEQEKIREEEKRQEQEE 477



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 67/258 (25%), Positives = 145/258 (56%), Gaps = 16/258 (6%)

Query: 536 EKERQRLENLRRKEEAEQLR--RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKE 593
           +K  + +E L ++ +A  L   R  + +++   L+E   K +E+L+ V   +  ++   +
Sbjct: 189 KKADRYIEELTKERDALSLELYRNTITDEE---LKEKNAKLQEKLQLVESEKSEIQLNVK 245

Query: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK-KMEEVEARRKQEEEARRLRWLQ 652
           E K+++E+    + ++  +A+ + L +E     A  + ++EE E   +  ++     W +
Sbjct: 246 ELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMW-R 304

Query: 653 QEEEERRHQELLQKKKE---EEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE 709
           QEE+ +  +E +Q+++E   E++E++R+  E  R  E+   E+ E+ RR++E    E+ E
Sbjct: 305 QEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM-WEKEE 363

Query: 710 QERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAE 769
           + RR++E    ++E+ R QE +  E+E + RE   ++ +++  RE EEK+++EE+ R  E
Sbjct: 364 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE 423

Query: 770 RQLQEE-----QEKKAKE 782
           ++ ++E     QE+K +E
Sbjct: 424 KRQEQEAKMWRQEEKIRE 441



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 59/229 (25%), Positives = 132/229 (57%), Gaps = 18/229 (7%)

Query: 527 RMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARE 586
           R + K    E+  +  E +  +E+  +  +++ +EDK  R EE   K  E+  KV +  E
Sbjct: 535 RQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEE---KIREQEEKVWRQEE 591

Query: 587 RVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEAR 646
           ++ + +E++++Q E+ + Q  E+  + +EE++ E++ K +   +K+ E E   +++EE  
Sbjct: 592 KIREQEEKRQEQEEKMWKQ--EEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEE-- 647

Query: 647 RLRWLQQEEEERRHQELLQKKKE---EEQERLRKAAEAKRLAEQREQERREQERREQERR 703
             +  +QEE+    +E +Q+++E    ++E++R+  + K++ EQ E+ R ++E  +++  
Sbjct: 648 --KMGEQEEKMCEQEEKMQEQEETMWRQEEKIRE--QEKKIREQEEKIREQEEMMQEQEE 703

Query: 704 EQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQ 752
           +   +E++  EQE ++ EQE +  ++    E ++ E+E  LR Q+E++Q
Sbjct: 704 KMWEQEEKMCEQEEKMQEQEEKMRRQ----EEKMWEQEVRLRQQEEKMQ 748



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 52/186 (27%), Positives = 110/186 (59%), Gaps = 19/186 (10%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
           EK R++ E + R+EE  ++R Q   E+KR+  EE   K+EE++R+    +E   Q +EEK
Sbjct: 577 EKIREQEEKVWRQEE--KIREQ---EEKRQEQEEKMWKQEEKIRE----QEEKIQEQEEK 627

Query: 596 KKQIEQKFAQIDEKTEKAKE------ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 649
            ++ E+K  + +E T++ +E      E++ E++ K +   + M   E + +++E+  R  
Sbjct: 628 IREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIR-- 685

Query: 650 WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE 709
             +QEE+ R  +E++Q+++E+  E+  K  E +   +++E++ R QE +  E+  + R++
Sbjct: 686 --EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 743

Query: 710 QERREQ 715
           +E+ ++
Sbjct: 744 EEKMQE 749


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score =  127 bits (318), Expect = 6e-29
 Identities = 88/282 (31%), Positives = 170/282 (60%), Gaps = 39/282 (13%)

Query: 536 EKERQRLENLRRKEEA-----EQLRRQKV----EEDKRRRLEEVKLKREERLRKVLQARE 586
           EK R++ E +RR+EE      E++RRQ+     +E+K RR EE+  ++EE++R++ +   
Sbjct: 389 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH 448

Query: 587 RVEQMKE-EKKKQIEQKFAQIDEKTE------------KAKEERLAEEKAKKKAAAKKME 633
             E+++E E+K+Q E+K  + +++ E            + +EE++ E++ K     +K+ 
Sbjct: 449 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIH 508

Query: 634 EVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKE--EEQERLRKAAEAKRLAEQR--- 688
           E E  R++E+   +    +QEE+ R  +E+ ++K++  E++E++RK  E     E++   
Sbjct: 509 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHD 568

Query: 689 -EQERREQE----RREQERREQER--REQER--REQERQLAEQERR---REQERLQAERE 736
            E++ REQE    R+E++ REQE   REQE   REQE    EQE +   +E++  + E +
Sbjct: 569 QEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK 628

Query: 737 LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 778
           +QE+E+ +R Q+E+++ + ++ +++EE+ R  E  +QE++EK
Sbjct: 629 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 670



 Score =  121 bits (303), Expect = 3e-27
 Identities = 91/281 (32%), Positives = 173/281 (61%), Gaps = 44/281 (15%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKV----EEDKRRRLEEVKLKREERLRKVLQARERVEQM 591
           EK R++ E +R +EE  ++RRQ+     +E+K RR EE+  ++EE++R+    +E +   
Sbjct: 382 EKIREQEEKIREQEE--KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR----QEEMMWE 435

Query: 592 KEEKKKQIEQKFAQ---IDEKTEKAKEE-RLAEEKAKKKAAAKKMEEVEARRKQEEEARR 647
           KEEK +++E+K  +   I E+ EK +EE ++ E++ +++  AK   + E  R+QEE+ R 
Sbjct: 436 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 495

Query: 648 LR---WLQQE---EEERRHQELLQKKKEE---EQERLRKAAEAKRLAE---QREQERREQ 695
                W Q+E   E+E+  +E  ++++EE   ++E++R+  E  R  E   ++E++ R+Q
Sbjct: 496 QEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQ 555

Query: 696 ERR-----------EQERREQE----RREQERREQERQLAEQERR-REQERLQAERE--L 737
           E +           E++ REQE    R+E++ REQE ++ EQE + REQE +  E+E  +
Sbjct: 556 EEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKM 615

Query: 738 QEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 778
            E+E+ +  Q+E++Q + E+ +++EE+ R  E++++E++EK
Sbjct: 616 GEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEK 656



 Score =  119 bits (297), Expect = 2e-26
 Identities = 82/272 (30%), Positives = 164/272 (60%), Gaps = 25/272 (9%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQM--KE 593
           EK R++ E +  KEE  +   +K+ E ++ R +E K + EE++R+  + +E+  +M  +E
Sbjct: 424 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 483

Query: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV----EARRKQEEEARRLR 649
           EK ++ E+K  + +EK  + +E+   +EK +++   ++ EE+    E  R+QEE  R+  
Sbjct: 484 EKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKE 543

Query: 650 WLQQEEEERRHQE----LLQKKKEEEQERLRKAAE-----AKRLAEQREQERREQER-RE 699
            + ++EE+ R QE      ++K  +++E++R+  E      +++ EQ E+ R ++E+ RE
Sbjct: 544 KIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIRE 603

Query: 700 QERREQERR----EQERR--EQERQLAEQE---RRREQERLQAERELQEREKALRLQKEQ 750
           QE   QE+     EQE +  EQE ++ EQE   RR+E++  + E++++E+E+ +R Q+E 
Sbjct: 604 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 663

Query: 751 LQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
           +Q + E+  ++EE+    E ++QE++EK  ++
Sbjct: 664 MQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 695



 Score =  117 bits (294), Expect = 4e-26
 Identities = 107/466 (22%), Positives = 229/466 (49%), Gaps = 40/466 (8%)

Query: 318 LAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKE 377
           L +K  LV  ++S ++   + L +K                LER   +   Q++ +E   
Sbjct: 287 LQEKLQLVESEKSEIQLNVKELKRK----------------LERAKLLLPQQQLQAEADH 330

Query: 378 PPEEAEPVAAA-EPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQ 436
             +E + V+A  + +V EN     W   + +        +      E     Q+E   +Q
Sbjct: 331 LGKELQSVSAKLQAQVEENE---LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ 387

Query: 437 ADGPREPPQSARRKRSYKQAVSELDEEQHLEDE---ELQPPRSKTPSSPCPASKVVRPLR 493
            +  RE  +  RR+   ++ + E +E+   ++E   E +    +         + +R L 
Sbjct: 388 EEKIREQEEKMRRQ---EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 444

Query: 494 TFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQ 553
             +H  ++ +           + +   ++    +M  +    EK R++ E +R +EE   
Sbjct: 445 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ---EEKIREQEEKIREQEEKMW 501

Query: 554 LRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKK-KQIEQKFAQIDEKTEK 612
            + +K+ E ++ R EE + ++EE  R+  + RE+ E  ++++K  + E+K  + +EK  +
Sbjct: 502 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWR 561

Query: 613 AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ 672
            +E+   +E+  ++   K   + E  R+QEE+ R     +QEE+ R  +E+ Q+++E+  
Sbjct: 562 QEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIR-----EQEEKIREQEEMTQEQEEKMG 616

Query: 673 ERLRKAAEAKRLAEQREQERREQERREQER-REQERREQERREQERQLAEQERRREQERL 731
           E+  K  E     E++ QE+ E+ RR++E+ REQE++ +E+ E+ R+  E  + +E++  
Sbjct: 617 EQEEKMCEQ----EEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 672

Query: 732 QAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQE 777
           + E ++ E+E+ ++ Q+E+++R+ E+  ++E + R  E ++QE QE
Sbjct: 673 EQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718



 Score =  116 bits (290), Expect = 1e-25
 Identities = 80/260 (30%), Positives = 161/260 (61%), Gaps = 21/260 (8%)

Query: 536 EKERQRLENLRRKEE-AEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 594
           E++RQ  E +R +E+  EQ  +   +E+K R  EE   ++EE++ +  +     E+++EE
Sbjct: 457 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREE 516

Query: 595 KKKQIEQKFAQIDEKTEKAKE-----ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 649
           +K+Q +++  + +EK  + +E     E++ E++ K +   +KM   E +   +EE  R  
Sbjct: 517 EKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIR-- 574

Query: 650 WLQQEEEERRHQELLQKKKE---EEQERLRKAAEAKRLAEQR--EQERR--EQERREQER 702
             +QEE+  R +E +++++E   E++E++R+  E  +  E++  EQE +  EQE + QE+
Sbjct: 575 --EQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ 632

Query: 703 REQERREQER-REQERQLAEQERR-REQERLQAERE--LQEREKALRLQKEQLQRELEEK 758
            E+ RR++E+ REQE+++ EQE + REQE +  E+E  + E+E+ +  Q+E++Q + E+ 
Sbjct: 633 EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKM 692

Query: 759 KKKEEQQRLAERQLQEEQEK 778
           +++EE+    E +L++++EK
Sbjct: 693 RRQEEKMWEQEVRLRQQEEK 712



 Score =  113 bits (282), Expect = 9e-25
 Identities = 78/276 (28%), Positives = 161/276 (58%), Gaps = 26/276 (9%)

Query: 527 RMDPKCSFVEKERQRLE----NLRRKEEAEQL-----RRQKVEEDKRRRLEEVKLKREER 577
           ++  K   VE E+  ++     L+RK E  +L     + Q   +   + L+ V  K + +
Sbjct: 286 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 345

Query: 578 LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA 637
           + +  +   R+ Q +EEK  + E+K  + +EK ++ +EE++ E++ K +   +KM   E 
Sbjct: 346 VEEN-ELWNRLNQQQEEKMWRQEEKIQEWEEKIQE-QEEKIREQEEKIREQEEKMRRQEE 403

Query: 638 RRKQEEEARR----LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR 693
              ++EE  R    + W ++EE+ RR +E++ +K+E+ +E   K  E +++ EQ E+ + 
Sbjct: 404 MMWEKEEKMRRQEEMMW-EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE 462

Query: 694 EQERREQERREQE-----RREQERREQERQLAEQERR--REQERLQAERELQEREKALRL 746
           E++ REQE+R+++     R+E++ REQE ++ EQE +  R++E++  + +++E EK  R 
Sbjct: 463 EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEK--RQ 520

Query: 747 QKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
           ++E++ R+ E+ +++EE  R  E+ + E++EK  K+
Sbjct: 521 EQEEMWRQEEKIREQEEIWRQKEK-IHEQEEKIRKQ 555



 Score =  112 bits (281), Expect = 1e-24
 Identities = 77/246 (31%), Positives = 148/246 (60%), Gaps = 22/246 (8%)

Query: 539 RQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ 598
           +Q+ E + R+EE  Q   +K++E + +  E+     EE++R+  +   R E+M  EK+++
Sbjct: 357 QQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ-----EEKIREQEEKMRRQEEMMWEKEEK 411

Query: 599 IEQKFAQIDEKTEKAK--EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 656
           + ++   + EK EK +  EE + E++ K +   +KM E E  R+QEE+       +QEEE
Sbjct: 412 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK-------RQEEE 464

Query: 657 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER-REQE--RREQERR 713
           + R QE    K++E++ ++ +  E  R  E++ +E+ E+  R++E+  EQE  R E++R+
Sbjct: 465 KIREQE----KRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQ 520

Query: 714 EQERQLAEQERRREQERLQAERE-LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQL 772
           EQE    ++E+ REQE +  ++E + E+E+ +R Q+E++ R+ E+   +EE+ R  E ++
Sbjct: 521 EQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKV 580

Query: 773 QEEQEK 778
             ++EK
Sbjct: 581 WRQEEK 586



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 73/262 (27%), Positives = 150/262 (57%), Gaps = 27/262 (10%)

Query: 543 ENLRRKEEAEQLRRQKVEEDKRR-RLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQ 601
           E L+ K    Q + Q VE +K   +L   +LKR+    K+L  +++++   +   K+++ 
Sbjct: 278 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 337

Query: 602 KFAQIDEKTEK---------AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 652
             A++  + E+          +EE++  ++ K +   +K++E E + +++EE      ++
Sbjct: 338 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK-----IR 392

Query: 653 QEEEERRHQELLQKKKEE----EQERLRKAAEAKRLAEQREQERREQERR-EQERREQE- 706
           ++EE+ R QE +  +KEE    ++E + +  E  R  E+   E+ E+ R  E++  EQE 
Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK 452

Query: 707 -RREQERREQERQLAEQERRREQE--RLQAERELQEREKALRLQKEQLQRELEEKKKKEE 763
            R ++E+R++E ++ EQE+R+EQE    + E +++E+E+ +R Q+E++ R+ E+  ++E+
Sbjct: 453 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEK 512

Query: 764 QQRLAERQLQEE---QEKKAKE 782
            +   +RQ QEE   QE+K +E
Sbjct: 513 IREEEKRQEQEEMWRQEEKIRE 534



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 65/250 (26%), Positives = 133/250 (53%), Gaps = 32/250 (12%)

Query: 536 EKERQRLENLRRKEEAEQLR--RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKE 593
           +K  + +E L ++ +A  L   R  + +++   L+E   K +E+L+ V   +  ++   +
Sbjct: 250 KKADRYIEELTKERDALSLELYRNTITDEE---LKEKNAKLQEKLQLVESEKSEIQLNVK 306

Query: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ 653
           E K+++E+    + ++  +A+ + L +E     A      +++A+ ++ E   RL   QQ
Sbjct: 307 ELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA------KLQAQVEENELWNRLNQ-QQ 359

Query: 654 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERR 713
           EE+  R +E +Q+ +E+ QE+                   E++ REQE + +E+ E+ RR
Sbjct: 360 EEKMWRQEEKIQEWEEKIQEQ-------------------EEKIREQEEKIREQEEKMRR 400

Query: 714 EQERQLAEQERRREQERLQAER-ELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQL 772
           ++E    ++E+ R QE +  E+ E   R++ +  +KE+  RELEEK  ++E+ R  E + 
Sbjct: 401 QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKR 460

Query: 773 QEEQEKKAKE 782
           QEE++ + +E
Sbjct: 461 QEEEKIREQE 470



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 47/155 (30%), Positives = 90/155 (58%), Gaps = 14/155 (9%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERL----RKVLQARERVE 589
           EK R++ E + R+EE  + + +K+  +E+K R  EE+  ++EE++     K+ +  E+++
Sbjct: 571 EKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQ 630

Query: 590 QMKEEKKKQ---IEQKFAQIDEKTEKAKE--ERLAEEKAKKKAAAKKM-EEVEARRKQEE 643
           + +E+ ++Q   I ++  +I E+ EK +E  E + E++ K     +KM E+ E  ++QEE
Sbjct: 631 EQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 690

Query: 644 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKA 678
           + RR      E+E R  Q+  ++K +E QE L  A
Sbjct: 691 KMRRQEEKMWEQEVRLRQQ--EEKMQEHQEHLEAA 723



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 66/270 (24%), Positives = 130/270 (48%), Gaps = 38/270 (14%)

Query: 540 QRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVL-QARERVEQMKEEKKKQ 598
           Q  E LRR+ EA Q+   ++   ++  L+      +  ++++  +AR+ + ++ +  K  
Sbjct: 177 QHQEALRRELEA-QVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFA 235

Query: 599 IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK------KMEEVEARRKQEEEARRLRWLQ 652
            E + A     T+K K +R  EE  K++ A         + + E + K  +   +L+ ++
Sbjct: 236 GELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVE 295

Query: 653 QEEEE-------------RRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE 699
            E+ E             R    L Q++ + E + L K  ++     Q + E  E   R 
Sbjct: 296 SEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL 355

Query: 700 QERREQE--RREQERREQERQLAEQERR-REQERLQAERELQEREKALRLQKEQLQRELE 756
            +++E++  R+E++ +E E ++ EQE + REQE      +++E+E+ +R Q+E +  E E
Sbjct: 356 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE-----KIREQEEKMRRQEEMMW-EKE 409

Query: 757 EKKK--------KEEQQRLAERQLQEEQEK 778
           EK +        KEE+ R  E  + E++EK
Sbjct: 410 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 439


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score =  117 bits (294), Expect = 4e-26
 Identities = 90/375 (24%), Positives = 175/375 (46%), Gaps = 17/375 (4%)

Query: 421 SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEE-----LQPPR 475
           SP     GQ     D  D  R   +   R+R  +Q   E D ++    E+         R
Sbjct: 36  SPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHR 95

Query: 476 SKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFV 535
            +         +     R      +RN+         R   +   ++    R   +    
Sbjct: 96  ERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDA 155

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRR---RLEEVKLKREERLRKVLQARERVEQMK 592
           EKER+R  +  R+ + E+ R+++ E +K R   R  E + ++E +       R R  + +
Sbjct: 156 EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERE 215

Query: 593 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 652
            E + + E+K     E+  + K ER  E++A+++ A+++  E +  R++E +  R R  +
Sbjct: 216 RETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRR 275

Query: 653 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 712
           Q+E ER+     Q++ E ++E  RK    +    +RE+ R+ +  RE+ER  + +RE ER
Sbjct: 276 QKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETER 335

Query: 713 -REQERQLAEQERRREQERLQAERELQE----REKALRLQKEQLQRELEEKKKKEEQQRL 767
            RE+ER    + +R+ Q  +  ER  Q     R +A R ++ + +R+ +  +++EE++R 
Sbjct: 336 DREKER----ERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERD 391

Query: 768 AERQLQEEQEKKAKE 782
            +R  Q+E+E++ ++
Sbjct: 392 RDRDRQKERERQTEK 406



 Score =  110 bits (275), Expect = 6e-24
 Identities = 66/256 (25%), Positives = 149/256 (58%), Gaps = 13/256 (5%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
           E+E +R  + +   + E+ R++  E+++ R+ +  + ++ ER R+  + RE+  Q + E+
Sbjct: 132 EREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRER 191

Query: 596 KKQIEQKFAQIDEKTEKAKE-----ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 650
           ++Q E++    D  +E+ +E     E   E + K++   ++  + +  R++E++A R R 
Sbjct: 192 ERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERA 251

Query: 651 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ 710
            ++E E  + +E   ++++ +++R R+  E +R  +++ Q R E++R  + +RE++R  +
Sbjct: 252 SERETERDKERE---RERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERE 308

Query: 711 ERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKE---EQQRL 767
             RE+ R+  E+ER RE+ER +     ++REK  R +K + Q E++ ++ ++   E +R 
Sbjct: 309 RERERNRK-RERERERERERERQRETERDREKE-RERKRKRQTEMDRERNRQTGREGRRQ 366

Query: 768 AERQLQEEQEKKAKEA 783
           AER+ + E+E+  + A
Sbjct: 367 AERERERERERDRQSA 382



 Score =  100 bits (250), Expect = 5e-21
 Identities = 73/258 (28%), Positives = 139/258 (53%), Gaps = 13/258 (5%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
           E+ R+R      + E E+ R+   E D++R+ E  + K+ ER R   +  ER ++ + E+
Sbjct: 207 ERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERER 266

Query: 596 KKQIE------QKFAQIDEKTEKAKE-ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 648
            +  +      ++  Q D K ++  E +R  E K +++   ++  E   +R++E E  R 
Sbjct: 267 DRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERE 326

Query: 649 RWLQQEEEERRHQELLQKKK---EEEQERLRKAAEAKRLAEQREQERREQERREQERREQ 705
           R  Q+E E  R +E  +K+K   E ++ER R+     R   +RE+ER E+ER  Q  RE+
Sbjct: 327 RERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERER-ERERDRQSARER 385

Query: 706 ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 765
           E RE++R +++RQ  E+ER+ E++R       ++RE+    + E+ +    E++K++ ++
Sbjct: 386 EERERDR-DRDRQ-KERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRE 443

Query: 766 RLAERQLQEEQEKKAKEA 783
           R  ERQ   +  ++ K +
Sbjct: 444 RDRERQTDRQAGRQRKRS 461



 Score =  100 bits (249), Expect = 6e-21
 Identities = 78/299 (26%), Positives = 154/299 (51%), Gaps = 44/299 (14%)

Query: 536 EKERQRLENLRRKE-EAEQLRRQKVEEDKRRR----LEEVKLKREERLRKVLQARERVEQ 590
           +KER+R    R+ E E ++ R ++ E+D+ R+     E  + + +ER R+  + R+R  +
Sbjct: 59  QKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQRE 118

Query: 591 MKEEKKKQIEQKFAQ-----IDEKTEKAKE---ERLAEEKAKKKAAAKKMEEVEARRKQE 642
            +  ++K+ E++  +      D +T+  +E   +R AE++ +++   ++  + E  R++E
Sbjct: 119 KERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKE 178

Query: 643 EE------ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQE 696
            E       RR R  Q+E+E +      ++ +E E+ER  +    ++    RE++R+ + 
Sbjct: 179 REREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKT 238

Query: 697 RREQERREQERREQER---REQERQLAEQERRREQERLQAERELQEREKALRL------- 746
            RE+E++ +  R  ER   R++ER+  E++R R+++R Q ERE Q   K  R        
Sbjct: 239 EREREKQAERERASERETERDKERE-RERDRDRDRDRRQKERERQTDRKRQRRTERDRET 297

Query: 747 -QKEQLQRELE-------------EKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALN 791
            +K + QRE E             E++++ E+QR  ER  ++E+E+K K      +  N
Sbjct: 298 ERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERN 356



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 81/343 (23%), Positives = 160/343 (46%), Gaps = 43/343 (12%)

Query: 429 QQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
           ++E +TD     RE  +   R R  K+   E + ++  E E  +   +KT        + 
Sbjct: 158 ERERQTD-----RERQRQTERNRQ-KEREREKNRQERRERERQREKENKTEDRHSERGRE 211

Query: 489 VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRK 548
               R      +R +         R   +   K+    R   + +  +KER+R     R 
Sbjct: 212 RERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERER----ERD 267

Query: 549 EEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDE 608
            + ++ RRQK   ++ R+ +  + +R ER R+  + RER  + + E+++           
Sbjct: 268 RDRDRDRRQK---ERERQTDRKRQRRTERDRETERKRERQRERERERER----------N 314

Query: 609 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK 668
           +  + + ER  E + +++    + +E E +RK++ E  R R  Q   E RR  E   +++
Sbjct: 315 RKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAE---RER 371

Query: 669 EEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQ 728
           E E+ER R++A        RE+E RE++R    ++E+ER+ ++ R+ +R+  E++R RE+
Sbjct: 372 ERERERDRQSA--------REREERERDRDRDRQKERERQTEKDRDGQRE-TEKQREREK 422

Query: 729 ERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ 771
           +R        E E+     +E+ +++  E+ ++ +  R A RQ
Sbjct: 423 DR--------ESERGRERGREREKQKGRERDRERQTDRQAGRQ 457



 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 52/203 (25%), Positives = 112/203 (55%), Gaps = 11/203 (5%)

Query: 584 ARERVEQMKEEKKKQIEQ--KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ 641
           +R R    +  +++ + Q  K A  D++    ++ER   E+ ++K   ++  + +  R++
Sbjct: 27  SRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKER---ERRREKRQTERETDRKRERRR 83

Query: 642 EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER---REQERR 698
           E++  R R   +E +  R +E  +++ + E++R R+    ++   +RE ER   R ++R+
Sbjct: 84  EKDRHRKRDRHRERQRDREKER-ERQTDRERDRQREKERNRQKERERETEREGERGRDRQ 142

Query: 699 EQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK 758
              +RE+ER+    +E+ERQ  ++ER+R+ ER + +   +E+ +  R ++E+ QRE E K
Sbjct: 143 TDGQRERERQRDAEKERERQ-TDRERQRQTERNRQKEREREKNRQERRERER-QREKENK 200

Query: 759 KKKEEQQRLAERQLQEEQEKKAK 781
            +    +R  ER+ + E E + +
Sbjct: 201 TEDRHSERGRERERERETETETE 223



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 35/122 (28%), Positives = 67/122 (54%), Gaps = 7/122 (5%)

Query: 670 EEQERLRKAAEAKRLAEQREQERREQERREQER------REQERREQERREQERQLAEQE 723
           +E  R R   +A + A+  ++ER  Q+ RE+ R      RE +R+ + RRE++R      
Sbjct: 34  QESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDR 93

Query: 724 RRREQERLQAERELQ-EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
            R  Q   + ERE Q +RE+  + +KE+ +++  E++ + E +R  +RQ   ++E++ + 
Sbjct: 94  HRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQR 153

Query: 783 AA 784
            A
Sbjct: 154 DA 155



 Score = 35.8 bits (81), Expect = 0.19
 Identities = 21/99 (21%), Positives = 50/99 (50%), Gaps = 13/99 (13%)

Query: 702 RREQERREQERR------------EQERQLAEQERRREQERLQAERELQEREKALRLQKE 749
           RR    +E  RR            +   +  ++ER R +E+ Q ERE  +R++  R +K+
Sbjct: 28  RRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERE-TDRKRERRREKD 86

Query: 750 QLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788
           + ++    ++++ ++++  ERQ   E++++ ++     K
Sbjct: 87  RHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQK 125


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score =  117 bits (294), Expect = 4e-26
 Identities = 83/250 (33%), Positives = 157/250 (62%), Gaps = 22/250 (8%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREER-LRKVLQARERVEQMKEE 594
           ++ER R +  + +E+ E++RRQ    +KR R +E +L+ +E+ LR+  + RE+ EQM+E+
Sbjct: 260 QEERLREQEGKMREQEEKMRRQ----EKRLREQEKELREQEKELREQKKLREQEEQMQEQ 315

Query: 595 KKKQIEQKFAQIDEKTEKA--KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 652
           ++K  EQ+  ++ E+ EK   +EERL E++ + +   +KM + E R  +++E      L+
Sbjct: 316 EEKMWEQE-EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER-----LR 369

Query: 653 QEEEERRHQELL--QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ 710
           ++EE  R QE +  Q++K +E+ER+R   E ++   + E+  REQE + Q++ E    ++
Sbjct: 370 EKEERMREQEKMWEQEEKMQEEERIR---EREKKMREEEETMREQEEKMQKQEENMWEQE 426

Query: 711 ERREQERQLAEQ-ERRREQERLQAERE-LQEREKALRLQKEQLQRELEEKKKKEEQQRLA 768
           E+  Q+++L EQ E+  EQE++Q + E + E+E+ +R Q+E   +  E+K  ++E+ R  
Sbjct: 427 EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ--EKKMWRQEKMREQ 484

Query: 769 ERQLQEEQEK 778
           E Q+ E++EK
Sbjct: 485 EDQMWEQEEK 494



 Score =  117 bits (294), Expect = 4e-26
 Identities = 87/279 (31%), Positives = 164/279 (58%), Gaps = 35/279 (12%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERL-RKVLQARERVEQMK 592
           EKE +  + LR +EE  Q + +K+  +E+K R  EE   ++EERL  +  Q RE+ ++M+
Sbjct: 296 EKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMR 355

Query: 593 EEKKKQIEQKFAQIDEKTEKAKE--------ERLAEEKAKKKAAAKKMEEVEARRKQEEE 644
           +++++  EQ   ++ EK E+ +E        E++ EE+  ++   K  EE E  R+QEE+
Sbjct: 356 DQEERMWEQD-ERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEK 414

Query: 645 ARRLR---WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 701
            ++     W Q+E+E ++ +   QK+K  EQE++++  E  ++ EQ E+ R ++E   QE
Sbjct: 415 MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE--KIWEQEEKIRDQEEMWGQE 472

Query: 702 R---REQERREQERR--EQERQLAEQERR---REQERLQAERELQEREKALRLQKEQLQR 753
           +   R+++ REQE +  EQE ++ +QE++   +E+   + +  L+E+E+ +R QK+  Q+
Sbjct: 473 KKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQ 532

Query: 754 E--LEEKKKKEEQ--------QRLAERQLQEEQEKKAKE 782
           E  + E+KK +EQ        +++ E +   E+EKK +E
Sbjct: 533 EEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMRE 571



 Score =  116 bits (291), Expect = 8e-26
 Identities = 77/263 (29%), Positives = 158/263 (60%), Gaps = 27/263 (10%)

Query: 536 EKERQRLENLRRKEEAEQLRRQK----VEEDKRRRLEEVKLKREERL-RKVLQARERVEQ 590
           E+E++  E  + +E+ EQ++ Q+     +E+K R  EE   ++EERL  +  Q RE+ ++
Sbjct: 294 EQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 353

Query: 591 MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 650
           M++++++  EQ   ++ EK E+ +E+    E+ +K    +++ E E + ++EEE  R   
Sbjct: 354 MRDQEERMWEQD-ERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMR--- 409

Query: 651 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER--REQER- 707
            +QEE+ ++ +E + +++E+E ++ R   + ++L EQ + + +E++  EQE   R+QE  
Sbjct: 410 -EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEM 468

Query: 708 --------REQERREQERQLAEQE---RRREQERLQAERELQEREKALRLQKEQLQRELE 756
                   R+++ REQE Q+ EQE   R +EQ+    E  + E+++ LR ++E+++   E
Sbjct: 469 WGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMR---E 525

Query: 757 EKKKKEEQQRLAERQLQEEQEKK 779
           +KK  ++++++ E +  +EQEKK
Sbjct: 526 QKKMWQQEEKMREEKKTQEQEKK 548



 Score =  116 bits (291), Expect = 8e-26
 Identities = 74/248 (29%), Positives = 146/248 (58%), Gaps = 14/248 (5%)

Query: 536 EKERQRLENLRRKEEA--EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKE 593
           EK+  R E +R +E+   EQ  + + +E K    EE   +++ERLR+  +     ++M +
Sbjct: 472 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQ 531

Query: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ 653
           +++K  E+K  Q  EK    +EE++ EE+  ++   K  EE E  R+QEE+      +Q+
Sbjct: 532 QEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK------MQE 585

Query: 654 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERR 713
           +EE+ R QE   +K  E++E++++  E     E++  E+ E+++ +++      +E++ +
Sbjct: 586 QEEKMREQE---EKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQ 642

Query: 714 EQERQLAEQERR-REQERLQAERE--LQEREKALRLQKEQLQRELEEKKKKEEQQRLAER 770
           EQE ++ EQE + REQE    E+E  +Q +E+ +R Q+E++Q + E+ +++EE+ R  E 
Sbjct: 643 EQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEE 702

Query: 771 QLQEEQEK 778
           ++  ++EK
Sbjct: 703 KMWGQEEK 710



 Score =  115 bits (288), Expect = 2e-25
 Identities = 69/257 (26%), Positives = 152/257 (59%), Gaps = 12/257 (4%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR-KVLQARERVEQMKEE 594
           +K R + E +  ++E  + + +++ E ++   +E K++ EER+R +  + RE  E M+E+
Sbjct: 352 QKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQ 411

Query: 595 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEAR-------- 646
           ++K  +Q+    +++ ++ +++RL E+K K     K  E+ E   +QEE+ R        
Sbjct: 412 EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ 471

Query: 647 -RLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ 705
            +  W Q++  E+  Q   Q++K  +QE+ +   + +R+ EQ E+ R ++ER  ++++  
Sbjct: 472 EKKMWRQEKMREQEDQMWEQEEKMRDQEQ-KMWDQEERMWEQDERLREKEERMREQKKMW 530

Query: 706 ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 765
           ++ E+ R E++ Q  E++   ++E+++ E  ++EREK +R ++E++ RE EEK +++E++
Sbjct: 531 QQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMR-EEEEMMREQEEKMQEQEEK 589

Query: 766 RLAERQLQEEQEKKAKE 782
              + +   EQE+K +E
Sbjct: 590 MREQEEKMWEQEEKMQE 606



 Score =  114 bits (285), Expect = 4e-25
 Identities = 74/254 (29%), Positives = 156/254 (61%), Gaps = 13/254 (5%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKRE--ERLRKVLQARERVEQMKE 593
           EK R++ + +  +EE  + + QK+ + + R  E+ +  RE  ER+R+  +  ++ E+M+E
Sbjct: 479 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMRE 538

Query: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR---- 649
           EKK Q EQ+    D++ +  +EER+ E + K +   + M E E + +++EE  R +    
Sbjct: 539 EKKTQ-EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKM 597

Query: 650 WLQQEEEERRHQELL-QKKKEEEQERLRKAAEAKRLAEQREQERREQERR--EQERREQE 706
           W Q+E+ + + +++  Q++K  EQE   K  E + +  ++E++ +EQE +  EQE + +E
Sbjct: 598 WEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMRE 657

Query: 707 RREQERREQERQLAEQERRREQ-ERLQAERE-LQEREKALRLQKEQLQRELEEKKKKEEQ 764
           + E+ R ++E+   ++E+ REQ E++Q + E ++E+E+ +R Q+E++  + EEK   +E+
Sbjct: 658 QEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQ-EEKMWGQEE 716

Query: 765 QRLAERQLQEEQEK 778
           +   + +++E++E+
Sbjct: 717 KMWGQEEMREKEER 730



 Score =  112 bits (281), Expect = 1e-24
 Identities = 77/271 (28%), Positives = 155/271 (57%), Gaps = 24/271 (8%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
           ++E+ R +  R +E+ ++LR Q+ E  ++++L E + + +E+  K+ +  E++ + +E+ 
Sbjct: 274 QEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKM 333

Query: 596 KKQIEQKFAQIDEKTE-----KAKEERLAE------EKAKKKAAAKKMEEVEARRKQEEE 644
            +Q E+ + Q  +  E     + +EER+ E      EK ++    +KM E E + ++EE 
Sbjct: 334 WRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEER 393

Query: 645 ARRLRWLQQEEEE--RRHQELLQKKKEEEQERLRKAAEAKRLAEQRE-----QERREQER 697
            R      +EEEE  R  +E +QK++E   E+  K  + +RL EQ+E     ++ +EQE 
Sbjct: 394 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE 453

Query: 698 REQERREQERREQERREQERQLAEQERRREQE--RLQAERELQEREKALRLQKEQLQREL 755
           +  E+ E+ R ++E   QE+++  QE+ REQE    + E +++++E+ +  Q+E++  + 
Sbjct: 454 KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQD 513

Query: 756 EEKKKKEEQQRLAERQLQEE----QEKKAKE 782
           E  ++KEE+ R  ++  Q+E    +EKK +E
Sbjct: 514 ERLREKEERMREQKKMWQQEEKMREEKKTQE 544



 Score =  112 bits (280), Expect = 2e-24
 Identities = 74/260 (28%), Positives = 154/260 (59%), Gaps = 21/260 (8%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERV---EQMK 592
           EK +++ EN+  +EE E  ++Q++ E K +  E+ K++ +E   K+ +  E++   E+M 
Sbjct: 413 EKMQKQEENMWEQEEKEW-QQQRLPEQKEKLWEQEKMQEQEE--KIWEQEEKIRDQEEMW 469

Query: 593 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR-RKQEEEARRLRWL 651
            ++KK   Q+  +  E     +EE++ +++ K     ++M E + R R++EE  R  + +
Sbjct: 470 GQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKM 529

Query: 652 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER--REQERREQERRE 709
            Q+EE+ R ++  Q+++++  ++  K  E +R+ E RE++ RE+E   REQE + QE+ E
Sbjct: 530 WQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRE-REKKMREEEEMMREQEEKMQEQEE 588

Query: 710 QERREQERQLAEQERRREQERLQAERE-----------LQEREKALRLQKEQLQRELEEK 758
           + R ++E+   ++E+ +EQE    E+E           +QE+E+ +  Q+E++Q + E+ 
Sbjct: 589 KMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKM 648

Query: 759 KKKEEQQRLAERQLQEEQEK 778
            ++EE+ R  E +++E++EK
Sbjct: 649 WEQEEKMREQEEKMREQEEK 668



 Score =  112 bits (279), Expect = 2e-24
 Identities = 90/295 (30%), Positives = 162/295 (54%), Gaps = 52/295 (17%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRL-----EEVKLKREERLRKVLQARERVEQ 590
           E++   LE  R     E+L+++  E  ++ RL      E++L  +E  RK+ +A+  + Q
Sbjct: 167 ERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQ 226

Query: 591 MK-----------EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR- 638
           ++           EE+ ++ E+K  + +EK  + +EERL E++ K +   +KM   E R 
Sbjct: 227 VQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR-QEERLREQEGKMREQEEKMRRQEKRL 285

Query: 639 -------RKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEA-----KRLAE 686
                  R+QE+E R  + L+++EE+ + QE   +K  E++E++R+  E      +RL E
Sbjct: 286 REQEKELREQEKELREQKKLREQEEQMQEQE---EKMWEQEEKMREQEEKMWRQEERLWE 342

Query: 687 QREQER-REQERREQERR-----------EQERREQERR-EQERQLAEQERRREQERLQA 733
           Q +Q R +EQ+ R+QE R           E+  REQE+  EQE ++ E+ER RE+E+   
Sbjct: 343 QEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMR 402

Query: 734 ERELQEREKALRLQK------EQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
           E E   RE+  ++QK      EQ ++E ++++  E++++L E++  +EQE+K  E
Sbjct: 403 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWE 457



 Score =  111 bits (277), Expect = 4e-24
 Identities = 67/250 (26%), Positives = 146/250 (58%), Gaps = 8/250 (3%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR-ERVEQMKEE 594
           EK  ++ E +R +EE     ++   ++K R  E+   ++EE++R   Q   ++ E+M E+
Sbjct: 453 EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQ 512

Query: 595 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 654
            ++  E++    ++K    +EE++ EEK  ++   K  ++ E  R++E    R + +++E
Sbjct: 513 DERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 572

Query: 655 EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERRE 714
           EE  R QE   +K +E++E++R+  E     E++ QE+ E+   ++E+  ++  E + +E
Sbjct: 573 EEMMREQE---EKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQE 629

Query: 715 QERQLAEQERR---REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ 771
           QE  + EQE +   +E++  + E +++E+E+ +R Q+E++Q + EEK +++E++   + +
Sbjct: 630 QEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQ-EEKMREQEEKMQGQEE 688

Query: 772 LQEEQEKKAK 781
              EQE+K +
Sbjct: 689 KMREQEEKMR 698



 Score =  110 bits (276), Expect = 5e-24
 Identities = 81/279 (29%), Positives = 159/279 (56%), Gaps = 42/279 (15%)

Query: 536 EKERQRLENLRRKEEA--EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKE 593
           EK R++ E + R+EE   EQ ++ + +E K R  EE   +++ERLR      E+ E+M+E
Sbjct: 324 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLR------EKEERMRE 377

Query: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ 653
           + +K  EQ+    +E+  + +E+++ EE+   +   +KM++ E    ++EE     W QQ
Sbjct: 378 Q-EKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK---EWQQQ 433

Query: 654 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQ---------REQERREQE----RREQ 700
              E++ +   Q+K +E++E++ +  E  R  E+         R+++ REQE     +E+
Sbjct: 434 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 493

Query: 701 ERREQERR--EQERR--EQERQLAEQERR--------REQERLQAERELQEREKAL---- 744
           + R+QE++  +QE R  EQ+ +L E+E R        +++E+++ E++ QE+EK      
Sbjct: 494 KMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQE 553

Query: 745 -RLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
            ++++E+  RE E+K ++EE+    + +  +EQE+K +E
Sbjct: 554 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMRE 592



 Score =  110 bits (275), Expect = 6e-24
 Identities = 71/244 (29%), Positives = 141/244 (57%), Gaps = 27/244 (11%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
           E+ R++ E +R +++  Q   +  EE K +  E+    +EE++R+  + RER ++M+EE+
Sbjct: 514 ERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE 573

Query: 596 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 655
           +   EQ      E+  + +EE++ E++ K     +KM+E E +  ++EE     W Q+EE
Sbjct: 574 EMMREQ------EEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKM---WEQEEE 624

Query: 656 EERRHQELLQKKKEEE-QERLRKAAEAKRLAEQREQERREQERR----EQERREQERR-- 708
           ++ + QE +  ++EE+ QE+  K  E +    ++E++ REQE +    E++ REQE +  
Sbjct: 625 DKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQ 684

Query: 709 --EQERREQERQLAEQERRR---------EQERLQAERELQEREKALRLQKEQLQRELEE 757
             E++ REQE ++  QE +          ++E++  + E++E+E+ +R QKE++Q  L E
Sbjct: 685 GQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPE 744

Query: 758 KKKK 761
            +++
Sbjct: 745 HEER 748



 Score =  109 bits (272), Expect = 1e-23
 Identities = 74/263 (28%), Positives = 149/263 (56%), Gaps = 25/263 (9%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
           E+ER R    + +EE E +R Q   E+K ++ EE   ++EE+  +  +  E+ E++ E++
Sbjct: 390 EEERIREREKKMREEEETMREQ---EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE 446

Query: 596 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR------ 649
           K Q +++  +I E+ EK +++     + KK    +KM E E +  ++EE  R +      
Sbjct: 447 KMQEQEE--KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWD 504

Query: 650 -----W-----LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE 699
                W     L+++EE  R Q+ + +++E+ +E  +   + K+  +Q E+ R E+  RE
Sbjct: 505 QEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRE 564

Query: 700 QERREQERREQERREQERQLAEQERRREQERLQAERE--LQEREKALRLQKEQLQRELEE 757
           +E++ +E  E  R ++E+   ++E+ REQE    E+E  +QE+E+ +  Q+E++  + EE
Sbjct: 565 REKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEE 624

Query: 758 KKKKEEQQRL--AERQLQEEQEK 778
            K +E+++ +   E ++QE++EK
Sbjct: 625 DKMQEQEEMMWEQEEKMQEQEEK 647



 Score =  104 bits (260), Expect = 3e-22
 Identities = 76/252 (30%), Positives = 153/252 (60%), Gaps = 26/252 (10%)

Query: 543 ENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVL-QARERVEQMKEEKKKQIEQ 601
           E + R+EE  +LR Q   E K R+ EE   ++EERLR+   + RE+ E+M+ ++K+  EQ
Sbjct: 234 EEMWRQEE--ELREQ---EKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQ 288

Query: 602 KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE---EEER 658
           +    +++ E  ++++L E++ + +   +KM E E + +++EE     W Q+E   E+E+
Sbjct: 289 EKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKM---WRQEERLWEQEK 345

Query: 659 RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQE-----RREQERR 713
           + +E  QK +++E+   R   + +RL E+ E+ R +++  EQE + QE      RE++ R
Sbjct: 346 QMREQEQKMRDQEE---RMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMR 402

Query: 714 EQERQLAEQERR--REQERLQAERELQEREKALRLQKEQL--QRELEEKKKK--EEQQRL 767
           E+E  + EQE +  +++E +  + E + +++ L  QKE+L  Q +++E+++K  E+++++
Sbjct: 403 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 462

Query: 768 AERQLQEEQEKK 779
            +++    QEKK
Sbjct: 463 RDQEEMWGQEKK 474



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 54/179 (30%), Positives = 101/179 (56%), Gaps = 15/179 (8%)

Query: 614 KEERLAEEKAKKKAAAK------KMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKK 667
           K +R  EE  K++ A         +   E ++K  E   +LR  + E+ E +      K+
Sbjct: 156 KADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKR 215

Query: 668 KEEEQERLRKAAEAKRLAEQ---REQERREQERREQERREQERREQER-REQERQLAEQE 723
           K E  + L    +   L E+   +E+E REQE++ +++ E+  R++ER REQE ++ EQE
Sbjct: 216 KLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQE 275

Query: 724 RRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
            +  ++    E+ L+E+EK LR Q+++L RE ++ +++EEQ +  E ++ E++EK  ++
Sbjct: 276 EKMRRQ----EKRLREQEKELREQEKEL-REQKKLREQEEQMQEQEEKMWEQEEKMREQ 329



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 50/184 (27%), Positives = 96/184 (52%), Gaps = 23/184 (12%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRR---RLEEVKLKREERLRKVLQARERVEQMK 592
           EK R++ E +  +EE  Q + +K+ E + +   + EE K++ +E +       E+ E+M+
Sbjct: 588 EKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEM-----MWEQEEKMQ 642

Query: 593 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 652
           E+++K  EQ      E+  + +EE++ E++ K +   +KM E E + + +EE  R     
Sbjct: 643 EQEEKMWEQ------EEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMR----- 691

Query: 653 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 712
           ++EE+ R QE    +K   QE      E K   ++  +E+ E+ R ++E+ ++   E E 
Sbjct: 692 EQEEKMRGQE----EKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEE 747

Query: 713 REQE 716
           R  E
Sbjct: 748 RCSE 751


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sapiens]
          Length = 1293

 Score =  116 bits (291), Expect = 8e-26
 Identities = 93/295 (31%), Positives = 159/295 (53%), Gaps = 36/295 (12%)

Query: 536  EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEV-KLKREERLRKVLQARERVEQMKEE 594
            E+ER+R E LRR++E E LRRQ+ EE KRR  EE+ + K+EE LR+  +    + + +EE
Sbjct: 746  EEERKRQEELRRQQE-EILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREE 804

Query: 595  KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 654
            +++Q      Q +E   + +E R  EE+ +K+         E  RKQEEEA   +W ++E
Sbjct: 805  EERQ------QQEEALRRLEERRREEEERRKQE--------ELLRKQEEEA--AKWAREE 848

Query: 655  EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERRE 714
            EE +R  E  + + EEE  RLR   E ++  E   Q ++E  R+ Q+++E  RR Q+ ++
Sbjct: 849  EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQ-QQ 907

Query: 715  QERQLAE----------QERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 764
            Q++QLA+          Q+      + QA   L E +K L  ++E+  RE E+++++ E 
Sbjct: 908  QQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQK-LEEERERQLRE-EQRRQQREL 965

Query: 765  QRLAERQLQEEQEK-----KAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAP 814
             +  ++Q Q++Q+K        + +G +K+L      ++      Q   Q H+ P
Sbjct: 966  MKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQP 1020



 Score =  114 bits (284), Expect = 5e-25
 Identities = 83/261 (31%), Positives = 147/261 (56%), Gaps = 33/261 (12%)

Query: 542 LENLRRKEEAE--QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQI 599
           LE L++ E+A+  +L +++ E + R + EE + KR+E LR+  Q  E + + +EE++K+ 
Sbjct: 717 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRR--QQEEILRRQQEEERKRR 774

Query: 600 EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 659
           E+      E+  + K+E     + +++ A ++  E E R++QEE  RRL   ++EEEERR
Sbjct: 775 EE------EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 828

Query: 660 HQELLQKKKEE----------------EQERLRKAAEAKRLAEQREQERREQERREQERR 703
            QE L +K+EE                E+ RLR   EA RL  + E+ER+ +E   Q ++
Sbjct: 829 KQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHE-EEERKRKELEVQRQK 887

Query: 704 EQERREQERREQERQLAEQERRRE--QERLQAERELQEREKALRLQKEQLQRELEEKKKK 761
           E  R+ Q+++E  R+L +Q+++++  Q +L +     ++      Q  Q    L E +K 
Sbjct: 888 ELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQ-SQATLSLAEIQKL 946

Query: 762 EEQQRLAERQLQEEQEKKAKE 782
           EE++   ERQL+EEQ ++ +E
Sbjct: 947 EEER---ERQLREEQRRQQRE 964



 Score =  104 bits (259), Expect = 4e-22
 Identities = 71/203 (34%), Positives = 117/203 (57%), Gaps = 25/203 (12%)

Query: 584 ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 643
           A E+++Q+++ K  ++EQ             E R AE +AK++   +K +E E RR+QEE
Sbjct: 716 ALEQLQQLEKAKAAKLEQ-------------ERREAEMRAKREEEERKRQE-ELRRQQEE 761

Query: 644 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERR 703
             RR    Q+EE +RR +E L ++K+EE  R ++  E     ++ E+ER++QE   +   
Sbjct: 762 ILRRQ---QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLE 818

Query: 704 EQERREQERREQERQLAEQERR-----REQERLQAERELQEREKALRLQKEQLQRELEEK 758
           E+ R E+ERR+QE  L +QE       RE+E  +A+R L+E    +  +  +L+ E EE+
Sbjct: 819 ERRREEEERRKQEELLRKQEEEAAKWAREEE--EAQRRLEENRLRMEEEAARLRHEEEER 876

Query: 759 KKKE-EQQRLAERQLQEEQEKKA 780
           K+KE E QR  E   Q +Q+++A
Sbjct: 877 KRKELEVQRQKELMRQRQQQQEA 899



 Score =  100 bits (248), Expect = 8e-21
 Identities = 67/182 (36%), Positives = 111/182 (60%), Gaps = 14/182 (7%)

Query: 606 IDEKTEKAKEERLAE-EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELL 664
           +D  T     E+L + EKAK     ++  E E R K+EEE R+    +QEE  R+ +E+L
Sbjct: 708 LDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERK----RQEELRRQQEEIL 763

Query: 665 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE----RREQERQLA 720
           ++++EEE++R  +   A+R  E+  + +REQE   + +RE+E R+Q+    RR +ER+  
Sbjct: 764 RRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE 823

Query: 721 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 780
           E+ERR+++E L+ + E  E  K  R ++E+ QR LEE + + E++  A R   EE+E+K 
Sbjct: 824 EEERRKQEELLRKQEE--EAAKWAR-EEEEAQRRLEENRLRMEEE--AARLRHEEEERKR 878

Query: 781 KE 782
           KE
Sbjct: 879 KE 880



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 60/240 (25%), Positives = 136/240 (56%), Gaps = 28/240 (11%)

Query: 535  VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 594
            + ++R+  E  +++E   +L  ++ EE++RR+ EE+  K+EE   K   ARE     +EE
Sbjct: 798  LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAK--WARE-----EEE 850

Query: 595  KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 654
             ++++E+   +++E+  + + E   EE+ +K+   ++ +E+  +R+Q++EA  LR LQQ+
Sbjct: 851  AQRRLEENRLRMEEEAARLRHEE--EERKRKELEVQRQKELMRQRQQQQEA--LRRLQQQ 906

Query: 655  EEERRHQELLQKKKEE-------------EQERLRKAAEAKRLAEQREQERREQERREQE 701
            +++   Q+L Q K                + +     AE ++L E+RE++ RE++RR+Q 
Sbjct: 907  QQQ---QQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQR 963

Query: 702  RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK 761
               +  ++Q++++Q++        +     ++  E+Q+ E+A ++QK+Q Q++  ++  +
Sbjct: 964  ELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQ-EEARQMQKQQQQQQQHQQPNR 1022



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 48/133 (36%), Positives = 85/133 (63%), Gaps = 11/133 (8%)

Query: 664 LQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER--REQERREQERREQERQLAE 721
           L+K K  + E+ R+ AE +   E+ E++R+E+ RR+QE   R Q+  E++RRE+E    E
Sbjct: 723 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE----E 778

Query: 722 QERRREQERLQAERELQ-----EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 776
             RR+++E L+ +RE +     +RE+  R Q+E+  R LEE++++EE++R  E  L++++
Sbjct: 779 LARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE 838

Query: 777 EKKAKEAAGASKA 789
           E+ AK A    +A
Sbjct: 839 EEAAKWAREEEEA 851



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 89/407 (21%), Positives = 173/407 (42%), Gaps = 75/407 (18%)

Query: 381  EAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPK-PAASSPETPSAGQQEAKTDQAD- 438
            E +P A+ +P V E  G + W   D  +  +TP P        E   A + E +  +A+ 
Sbjct: 687  ELQPTAS-QPTVWE--GGSVW---DLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEM 740

Query: 439  -GPREPPQSARR---KRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRT 494
               RE  +  R+   +R  ++ +    EE+    EE +  R K   +     +    LR 
Sbjct: 741  RAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRR 800

Query: 495  FLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQL 554
                 +R Q                 +     R++ +    E+ R++ E LR++EE E  
Sbjct: 801  QREEEERQQ-----------------QEEALRRLEERRREEEERRKQEELLRKQEE-EAA 842

Query: 555  RRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 614
            +  + EE+ +RRLEE +L+ EE                                  E A+
Sbjct: 843  KWAREEEEAQRRLEENRLRMEE----------------------------------EAAR 868

Query: 615  EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER 674
                 EE+ +K+   ++ +E+  +R+Q++EA R R  QQ+++++  Q  L       Q+ 
Sbjct: 869  LRHEEEERKRKELEVQRQKELMRQRQQQQEALR-RLQQQQQQQQLAQMKLPSSSTWGQQS 927

Query: 675  LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE 734
               A +++      E ++ E+ER  Q R EQ R+++E      +  +Q+++++Q++L   
Sbjct: 928  NTTACQSQATLSLAEIQKLEEERERQLREEQRRQQREL----MKALQQQQQQQQQKLSGW 983

Query: 735  RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 781
              + +     +   E  Q E  + +K+++QQ+      Q +Q  +A+
Sbjct: 984  GNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQ------QHQQPNRAR 1024



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 112/535 (20%), Positives = 205/535 (38%), Gaps = 101/535 (18%)

Query: 287 PDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEE 346
           PD  +   G +TD   V  S   P + S        S    QE+   +  R+   KT + 
Sbjct: 342 PDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEA--SQFERKDEPKTEQT 399

Query: 347 PAASGRIICHSYLERLLNVEVPQKVGSEQ---------KEPPEEAEPVAAAEPEVPENNG 397
             A       + +E  L  +VP + G E          + P + A P+    P VP    
Sbjct: 400 EKAEEE----TRMENSLPAKVPSR-GDEMVADVQQPLSQIPSDTASPLLILPPPVP---- 450

Query: 398 NNSWPHNDTEIANSTPNPKPAASSPETP-----SAGQQEAKTDQADGPREPPQSARRKRS 452
                           NP P     ETP       G    + D  +G +   Q A +  +
Sbjct: 451 ----------------NPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVA 494

Query: 453 YKQAVSELDEEQHLEDEELQPPRSKTPSSPC------------PASKVVRPLRTFLHTVQ 500
           Y Q  S LD+E+     +LQ  R+K  S P             P  ++  P         
Sbjct: 495 YLQD-SALDDERLAS--KLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFN------- 544

Query: 501 RNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVE 560
            NQ +     A    M   +KR             ++  Q L ++ +             
Sbjct: 545 -NQEMAEWFQAGYFTMSLLVKRAC-----------DESFQPLGDIMKMWGRVPFSPGPAP 592

Query: 561 EDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAE 620
                 L++ +L R++ L  + Q      Q  + ++  I+Q++AQ+      A++++ A 
Sbjct: 593 PPHMGELDQERLTRQQELTALYQM-----QHLQYQQFLIQQQYAQV-----LAQQQKAAL 642

Query: 621 EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER------ 674
              +++  A  +++ +  + +  +   +  + +         + + +    Q        
Sbjct: 643 SSQQQQQLALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGS 702

Query: 675 -----LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQE 729
                L        L + ++ E+ +  + EQERRE E R + R E+ER+  E+ RR+++E
Sbjct: 703 VWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAK-REEEERKRQEELRRQQEE 761

Query: 730 RLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA-ERQLQEEQEKKAKEA 783
            L   R  QE E+  R ++E  +R+ EE  +++ +Q +A  RQ +EE+ ++ +EA
Sbjct: 762 IL---RRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEA 813



 Score = 34.3 bits (77), Expect = 0.55
 Identities = 21/93 (22%), Positives = 50/93 (53%), Gaps = 1/93 (1%)

Query: 675  LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE 734
            L   +EAK  A+Q   ERR +++  Q+R++Q+  +Q++++  +Q  +Q ++++       
Sbjct: 1172 LGDTSEAKEFAKQF-LERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNH 1230

Query: 735  RELQEREKALRLQKEQLQRELEEKKKKEEQQRL 767
              L    +  +   +Q   E  +  KK+++Q++
Sbjct: 1231 STLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKM 1263



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 35/168 (20%), Positives = 73/168 (43%), Gaps = 14/168 (8%)

Query: 17  QKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQD 76
           +K  E L   + +   W  E +EEA+R       +  E   +   ++  RK++ +  VQ 
Sbjct: 828 RKQEELLRKQEEEAAKWARE-EEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE-VQ- 884

Query: 77  ENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATM 136
                 R++   R+ +  Q + RRL+ +   ++LA +   + S   + +   A  + AT+
Sbjct: 885 ------RQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATL 938

Query: 137 ALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVT 184
           +LA       E    L  + E    Q +L+  ++    ++Q  +Q ++
Sbjct: 939 SLAEIQKLEEERERQL--REEQRRQQRELMKALQ---QQQQQQQQKLS 981


>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
          Length = 1320

 Score =  116 bits (291), Expect = 8e-26
 Identities = 93/295 (31%), Positives = 159/295 (53%), Gaps = 36/295 (12%)

Query: 536  EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEV-KLKREERLRKVLQARERVEQMKEE 594
            E+ER+R E LRR++E E LRRQ+ EE KRR  EE+ + K+EE LR+  +    + + +EE
Sbjct: 773  EEERKRQEELRRQQE-EILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREE 831

Query: 595  KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 654
            +++Q      Q +E   + +E R  EE+ +K+         E  RKQEEEA +  W ++E
Sbjct: 832  EERQ------QQEEALRRLEERRREEEERRKQE--------ELLRKQEEEAAK--WAREE 875

Query: 655  EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERRE 714
            EE +R  E  + + EEE  RLR   E ++  E   Q ++E  R+ Q+++E  RR Q+ ++
Sbjct: 876  EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQ-QQ 934

Query: 715  QERQLAE----------QERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 764
            Q++QLA+          Q+      + QA   L E +K L  ++E+  RE E+++++ E 
Sbjct: 935  QQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQK-LEEERERQLRE-EQRRQQREL 992

Query: 765  QRLAERQLQEEQEK-----KAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAP 814
             +  ++Q Q++Q+K        + +G +K+L      ++      Q   Q H+ P
Sbjct: 993  MKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQP 1047



 Score =  114 bits (284), Expect = 5e-25
 Identities = 83/261 (31%), Positives = 147/261 (56%), Gaps = 33/261 (12%)

Query: 542 LENLRRKEEAE--QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQI 599
           LE L++ E+A+  +L +++ E + R + EE + KR+E LR+  Q  E + + +EE++K+ 
Sbjct: 744 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRR--QQEEILRRQQEEERKRR 801

Query: 600 EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 659
           E+      E+  + K+E     + +++ A ++  E E R++QEE  RRL   ++EEEERR
Sbjct: 802 EE------EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 855

Query: 660 HQELLQKKKEEE----------------QERLRKAAEAKRLAEQREQERREQERREQERR 703
            QE L +K+EEE                + RLR   EA RL  + E+ER+ +E   Q ++
Sbjct: 856 KQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHE-EEERKRKELEVQRQK 914

Query: 704 EQERREQERREQERQLAEQERRRE--QERLQAERELQEREKALRLQKEQLQRELEEKKKK 761
           E  R+ Q+++E  R+L +Q+++++  Q +L +     ++      Q  Q    L E +K 
Sbjct: 915 ELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQ-SQATLSLAEIQKL 973

Query: 762 EEQQRLAERQLQEEQEKKAKE 782
           EE++   ERQL+EEQ ++ +E
Sbjct: 974 EEER---ERQLREEQRRQQRE 991



 Score =  104 bits (259), Expect = 4e-22
 Identities = 71/203 (34%), Positives = 117/203 (57%), Gaps = 25/203 (12%)

Query: 584 ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 643
           A E+++Q+++ K  ++EQ             E R AE +AK++   +K +E E RR+QEE
Sbjct: 743 ALEQLQQLEKAKAAKLEQ-------------ERREAEMRAKREEEERKRQE-ELRRQQEE 788

Query: 644 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERR 703
             RR    Q+EE +RR +E L ++K+EE  R ++  E     ++ E+ER++QE   +   
Sbjct: 789 ILRRQ---QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLE 845

Query: 704 EQERREQERREQERQLAEQERR-----REQERLQAERELQEREKALRLQKEQLQRELEEK 758
           E+ R E+ERR+QE  L +QE       RE+E  +A+R L+E    +  +  +L+ E EE+
Sbjct: 846 ERRREEEERRKQEELLRKQEEEAAKWAREEE--EAQRRLEENRLRMEEEAARLRHEEEER 903

Query: 759 KKKE-EQQRLAERQLQEEQEKKA 780
           K+KE E QR  E   Q +Q+++A
Sbjct: 904 KRKELEVQRQKELMRQRQQQQEA 926



 Score =  100 bits (248), Expect = 8e-21
 Identities = 67/182 (36%), Positives = 111/182 (60%), Gaps = 14/182 (7%)

Query: 606 IDEKTEKAKEERLAE-EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELL 664
           +D  T     E+L + EKAK     ++  E E R K+EEE R+    +QEE  R+ +E+L
Sbjct: 735 LDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERK----RQEELRRQQEEIL 790

Query: 665 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE----RREQERQLA 720
           ++++EEE++R  +   A+R  E+  + +REQE   + +RE+E R+Q+    RR +ER+  
Sbjct: 791 RRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE 850

Query: 721 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 780
           E+ERR+++E L+ + E  E  K  R ++E+ QR LEE + + E++  A R   EE+E+K 
Sbjct: 851 EEERRKQEELLRKQEE--EAAKWAR-EEEEAQRRLEENRLRMEEE--AARLRHEEEERKR 905

Query: 781 KE 782
           KE
Sbjct: 906 KE 907



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 60/240 (25%), Positives = 136/240 (56%), Gaps = 28/240 (11%)

Query: 535  VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 594
            + ++R+  E  +++E   +L  ++ EE++RR+ EE+  K+EE   K   ARE     +EE
Sbjct: 825  LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAK--WARE-----EEE 877

Query: 595  KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 654
             ++++E+   +++E+  + + E   EE+ +K+   ++ +E+  +R+Q++EA  LR LQQ+
Sbjct: 878  AQRRLEENRLRMEEEAARLRHEE--EERKRKELEVQRQKELMRQRQQQQEA--LRRLQQQ 933

Query: 655  EEERRHQELLQKKKEE-------------EQERLRKAAEAKRLAEQREQERREQERREQE 701
            +++   Q+L Q K                + +     AE ++L E+RE++ RE++RR+Q 
Sbjct: 934  QQQ---QQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQR 990

Query: 702  RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK 761
               +  ++Q++++Q++        +     ++  E+Q+ E+A ++QK+Q Q++  ++  +
Sbjct: 991  ELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQ-EEARQMQKQQQQQQQHQQPNR 1049



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 48/133 (36%), Positives = 85/133 (63%), Gaps = 11/133 (8%)

Query: 664 LQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER--REQERREQERREQERQLAE 721
           L+K K  + E+ R+ AE +   E+ E++R+E+ RR+QE   R Q+  E++RRE+E    E
Sbjct: 750 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE----E 805

Query: 722 QERRREQERLQAERELQ-----EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 776
             RR+++E L+ +RE +     +RE+  R Q+E+  R LEE++++EE++R  E  L++++
Sbjct: 806 LARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE 865

Query: 777 EKKAKEAAGASKA 789
           E+ AK A    +A
Sbjct: 866 EEAAKWAREEEEA 878



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 89/407 (21%), Positives = 173/407 (42%), Gaps = 75/407 (18%)

Query: 381  EAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPK-PAASSPETPSAGQQEAKTDQAD- 438
            E +P A+ +P V E  G + W   D  +  +TP P        E   A + E +  +A+ 
Sbjct: 714  ELQPTAS-QPTVWE--GGSVW---DLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEM 767

Query: 439  -GPREPPQSARR---KRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRT 494
               RE  +  R+   +R  ++ +    EE+    EE +  R K   +     +    LR 
Sbjct: 768  RAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRR 827

Query: 495  FLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQL 554
                 +R Q                 +     R++ +    E+ R++ E LR++EE E  
Sbjct: 828  QREEEERQQ-----------------QEEALRRLEERRREEEERRKQEELLRKQEE-EAA 869

Query: 555  RRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 614
            +  + EE+ +RRLEE +L+ EE                                  E A+
Sbjct: 870  KWAREEEEAQRRLEENRLRMEE----------------------------------EAAR 895

Query: 615  EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER 674
                 EE+ +K+   ++ +E+  +R+Q++EA R R  QQ+++++  Q  L       Q+ 
Sbjct: 896  LRHEEEERKRKELEVQRQKELMRQRQQQQEALR-RLQQQQQQQQLAQMKLPSSSTWGQQS 954

Query: 675  LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE 734
               A +++      E ++ E+ER  Q R EQ R+++E      +  +Q+++++Q++L   
Sbjct: 955  NTTACQSQATLSLAEIQKLEEERERQLREEQRRQQREL----MKALQQQQQQQQQKLSGW 1010

Query: 735  RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 781
              + +     +   E  Q E  + +K+++QQ+      Q +Q  +A+
Sbjct: 1011 GNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQ------QHQQPNRAR 1051



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 85/400 (21%), Positives = 164/400 (41%), Gaps = 65/400 (16%)

Query: 413 PNPKPAASSPETP-----SAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLE 467
           PNP P     ETP       G    + D  +G +   Q A +  +Y Q  S LD+E+   
Sbjct: 477 PNPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVAYLQD-SALDDERLAS 535

Query: 468 DEELQPPRSKTPSSPC------------PASKVVRPLRTFLHTVQRNQMLMTPTSAPRSV 515
             +LQ  R+K  S P             P  ++  P          NQ +     A    
Sbjct: 536 --KLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFN--------NQEMAEWFQAGYFT 585

Query: 516 MKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKRE 575
           M   +KR             ++  Q L ++ +                   L++ +L R+
Sbjct: 586 MSLLVKRAC-----------DESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQ 634

Query: 576 ERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV 635
           + L  + Q      Q  + ++  I+Q++AQ+      A++++ A    +++  A  +++ 
Sbjct: 635 QELTALYQM-----QHLQYQQFLIQQQYAQV-----LAQQQKAALSSQQQQQLALLLQQF 684

Query: 636 EARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER-----------LRKAAEAKRL 684
           +  + +  +   +  + +         + + +    Q             L        L
Sbjct: 685 QTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPAL 744

Query: 685 AEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKAL 744
            + ++ E+ +  + EQERRE E R + R E+ER+  E+ RR+++E L   R  QE E+  
Sbjct: 745 EQLQQLEKAKAAKLEQERREAEMRAK-REEEERKRQEELRRQQEEIL---RRQQEEERKR 800

Query: 745 RLQKEQLQRELEEKKKKEEQQRLA-ERQLQEEQEKKAKEA 783
           R ++E  +R+ EE  +++ +Q +A  RQ +EE+ ++ +EA
Sbjct: 801 REEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEA 840



 Score = 34.3 bits (77), Expect = 0.55
 Identities = 21/93 (22%), Positives = 50/93 (53%), Gaps = 1/93 (1%)

Query: 675  LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE 734
            L   +EAK  A+Q   ERR +++  Q+R++Q+  +Q++++  +Q  +Q ++++       
Sbjct: 1199 LGDTSEAKEFAKQF-LERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNH 1257

Query: 735  RELQEREKALRLQKEQLQRELEEKKKKEEQQRL 767
              L    +  +   +Q   E  +  KK+++Q++
Sbjct: 1258 STLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKM 1290



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 35/168 (20%), Positives = 73/168 (43%), Gaps = 14/168 (8%)

Query: 17   QKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQD 76
            +K  E L   + +   W  E +EEA+R       +  E   +   ++  RK++ +  VQ 
Sbjct: 855  RKQEELLRKQEEEAAKWARE-EEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE-VQ- 911

Query: 77   ENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATM 136
                  R++   R+ +  Q + RRL+ +   ++LA +   + S   + +   A  + AT+
Sbjct: 912  ------RQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATL 965

Query: 137  ALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVT 184
            +LA       E    L  + E    Q +L+  ++    ++Q  +Q ++
Sbjct: 966  SLAEIQKLEEERERQL--REEQRRQQRELMKALQ---QQQQQQQQKLS 1008


>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
          Length = 1299

 Score =  116 bits (291), Expect = 8e-26
 Identities = 93/295 (31%), Positives = 159/295 (53%), Gaps = 36/295 (12%)

Query: 536  EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEV-KLKREERLRKVLQARERVEQMKEE 594
            E+ER+R E LRR++E E LRRQ+ EE KRR  EE+ + K+EE LR+  +    + + +EE
Sbjct: 752  EEERKRQEELRRQQE-EILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREE 810

Query: 595  KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 654
            +++Q      Q +E   + +E R  EE+ +K+         E  RKQEEEA   +W ++E
Sbjct: 811  EERQ------QQEEALRRLEERRREEEERRKQE--------ELLRKQEEEA--AKWAREE 854

Query: 655  EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERRE 714
            EE +R  E  + + EEE  RLR   E ++  E   Q ++E  R+ Q+++E  RR Q+ ++
Sbjct: 855  EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQ-QQ 913

Query: 715  QERQLAE----------QERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 764
            Q++QLA+          Q+      + QA   L E +K L  ++E+  RE E+++++ E 
Sbjct: 914  QQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQK-LEEERERQLRE-EQRRQQREL 971

Query: 765  QRLAERQLQEEQEK-----KAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAP 814
             +  ++Q Q++Q+K        + +G +K+L      ++      Q   Q H+ P
Sbjct: 972  MKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQP 1026



 Score =  114 bits (284), Expect = 5e-25
 Identities = 83/261 (31%), Positives = 147/261 (56%), Gaps = 33/261 (12%)

Query: 542 LENLRRKEEAE--QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQI 599
           LE L++ E+A+  +L +++ E + R + EE + KR+E LR+  Q  E + + +EE++K+ 
Sbjct: 723 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRR--QQEEILRRQQEEERKRR 780

Query: 600 EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 659
           E+      E+  + K+E     + +++ A ++  E E R++QEE  RRL   ++EEEERR
Sbjct: 781 EE------EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 834

Query: 660 HQELLQKKKEE----------------EQERLRKAAEAKRLAEQREQERREQERREQERR 703
            QE L +K+EE                E+ RLR   EA RL  + E+ER+ +E   Q ++
Sbjct: 835 KQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHE-EEERKRKELEVQRQK 893

Query: 704 EQERREQERREQERQLAEQERRRE--QERLQAERELQEREKALRLQKEQLQRELEEKKKK 761
           E  R+ Q+++E  R+L +Q+++++  Q +L +     ++      Q  Q    L E +K 
Sbjct: 894 ELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQ-SQATLSLAEIQKL 952

Query: 762 EEQQRLAERQLQEEQEKKAKE 782
           EE++   ERQL+EEQ ++ +E
Sbjct: 953 EEER---ERQLREEQRRQQRE 970



 Score =  104 bits (259), Expect = 4e-22
 Identities = 71/203 (34%), Positives = 117/203 (57%), Gaps = 25/203 (12%)

Query: 584 ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 643
           A E+++Q+++ K  ++EQ             E R AE +AK++   +K +E E RR+QEE
Sbjct: 722 ALEQLQQLEKAKAAKLEQ-------------ERREAEMRAKREEEERKRQE-ELRRQQEE 767

Query: 644 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERR 703
             RR    Q+EE +RR +E L ++K+EE  R ++  E     ++ E+ER++QE   +   
Sbjct: 768 ILRRQ---QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLE 824

Query: 704 EQERREQERREQERQLAEQERR-----REQERLQAERELQEREKALRLQKEQLQRELEEK 758
           E+ R E+ERR+QE  L +QE       RE+E  +A+R L+E    +  +  +L+ E EE+
Sbjct: 825 ERRREEEERRKQEELLRKQEEEAAKWAREEE--EAQRRLEENRLRMEEEAARLRHEEEER 882

Query: 759 KKKE-EQQRLAERQLQEEQEKKA 780
           K+KE E QR  E   Q +Q+++A
Sbjct: 883 KRKELEVQRQKELMRQRQQQQEA 905



 Score =  100 bits (248), Expect = 8e-21
 Identities = 67/182 (36%), Positives = 111/182 (60%), Gaps = 14/182 (7%)

Query: 606 IDEKTEKAKEERLAE-EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELL 664
           +D  T     E+L + EKAK     ++  E E R K+EEE R+    +QEE  R+ +E+L
Sbjct: 714 LDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERK----RQEELRRQQEEIL 769

Query: 665 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE----RREQERQLA 720
           ++++EEE++R  +   A+R  E+  + +REQE   + +RE+E R+Q+    RR +ER+  
Sbjct: 770 RRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE 829

Query: 721 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 780
           E+ERR+++E L+ + E  E  K  R ++E+ QR LEE + + E++  A R   EE+E+K 
Sbjct: 830 EEERRKQEELLRKQEE--EAAKWAR-EEEEAQRRLEENRLRMEEE--AARLRHEEEERKR 884

Query: 781 KE 782
           KE
Sbjct: 885 KE 886



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 60/240 (25%), Positives = 136/240 (56%), Gaps = 28/240 (11%)

Query: 535  VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 594
            + ++R+  E  +++E   +L  ++ EE++RR+ EE+  K+EE   K   ARE     +EE
Sbjct: 804  LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAK--WARE-----EEE 856

Query: 595  KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 654
             ++++E+   +++E+  + + E   EE+ +K+   ++ +E+  +R+Q++EA  LR LQQ+
Sbjct: 857  AQRRLEENRLRMEEEAARLRHEE--EERKRKELEVQRQKELMRQRQQQQEA--LRRLQQQ 912

Query: 655  EEERRHQELLQKKKEE-------------EQERLRKAAEAKRLAEQREQERREQERREQE 701
            +++   Q+L Q K                + +     AE ++L E+RE++ RE++RR+Q 
Sbjct: 913  QQQ---QQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQR 969

Query: 702  RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK 761
               +  ++Q++++Q++        +     ++  E+Q+ E+A ++QK+Q Q++  ++  +
Sbjct: 970  ELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQ-EEARQMQKQQQQQQQHQQPNR 1028



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 48/133 (36%), Positives = 85/133 (63%), Gaps = 11/133 (8%)

Query: 664 LQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER--REQERREQERREQERQLAE 721
           L+K K  + E+ R+ AE +   E+ E++R+E+ RR+QE   R Q+  E++RRE+E    E
Sbjct: 729 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE----E 784

Query: 722 QERRREQERLQAERELQ-----EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 776
             RR+++E L+ +RE +     +RE+  R Q+E+  R LEE++++EE++R  E  L++++
Sbjct: 785 LARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE 844

Query: 777 EKKAKEAAGASKA 789
           E+ AK A    +A
Sbjct: 845 EEAAKWAREEEEA 857



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 89/407 (21%), Positives = 173/407 (42%), Gaps = 75/407 (18%)

Query: 381  EAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPK-PAASSPETPSAGQQEAKTDQAD- 438
            E +P A+ +P V E  G + W   D  +  +TP P        E   A + E +  +A+ 
Sbjct: 693  ELQPTAS-QPTVWE--GGSVW---DLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEM 746

Query: 439  -GPREPPQSARR---KRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRT 494
               RE  +  R+   +R  ++ +    EE+    EE +  R K   +     +    LR 
Sbjct: 747  RAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRR 806

Query: 495  FLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQL 554
                 +R Q                 +     R++ +    E+ R++ E LR++EE E  
Sbjct: 807  QREEEERQQ-----------------QEEALRRLEERRREEEERRKQEELLRKQEE-EAA 848

Query: 555  RRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 614
            +  + EE+ +RRLEE +L+ EE                                  E A+
Sbjct: 849  KWAREEEEAQRRLEENRLRMEE----------------------------------EAAR 874

Query: 615  EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER 674
                 EE+ +K+   ++ +E+  +R+Q++EA R R  QQ+++++  Q  L       Q+ 
Sbjct: 875  LRHEEEERKRKELEVQRQKELMRQRQQQQEALR-RLQQQQQQQQLAQMKLPSSSTWGQQS 933

Query: 675  LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE 734
               A +++      E ++ E+ER  Q R EQ R+++E      +  +Q+++++Q++L   
Sbjct: 934  NTTACQSQATLSLAEIQKLEEERERQLREEQRRQQREL----MKALQQQQQQQQQKLSGW 989

Query: 735  RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 781
              + +     +   E  Q E  + +K+++QQ+      Q +Q  +A+
Sbjct: 990  GNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQ------QHQQPNRAR 1030



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 112/535 (20%), Positives = 205/535 (38%), Gaps = 101/535 (18%)

Query: 287 PDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEE 346
           PD  +   G +TD   V  S   P + S        S    QE+   +  R+   KT + 
Sbjct: 348 PDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEA--SQFERKDEPKTEQT 405

Query: 347 PAASGRIICHSYLERLLNVEVPQKVGSEQ---------KEPPEEAEPVAAAEPEVPENNG 397
             A       + +E  L  +VP + G E          + P + A P+    P VP    
Sbjct: 406 EKAEEE----TRMENSLPAKVPSR-GDEMVADVQQPLSQIPSDTASPLLILPPPVP---- 456

Query: 398 NNSWPHNDTEIANSTPNPKPAASSPETP-----SAGQQEAKTDQADGPREPPQSARRKRS 452
                           NP P     ETP       G    + D  +G +   Q A +  +
Sbjct: 457 ----------------NPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVA 500

Query: 453 YKQAVSELDEEQHLEDEELQPPRSKTPSSPC------------PASKVVRPLRTFLHTVQ 500
           Y Q  S LD+E+     +LQ  R+K  S P             P  ++  P         
Sbjct: 501 YLQD-SALDDERLAS--KLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFN------- 550

Query: 501 RNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVE 560
            NQ +     A    M   +KR             ++  Q L ++ +             
Sbjct: 551 -NQEMAEWFQAGYFTMSLLVKRAC-----------DESFQPLGDIMKMWGRVPFSPGPAP 598

Query: 561 EDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAE 620
                 L++ +L R++ L  + Q      Q  + ++  I+Q++AQ+      A++++ A 
Sbjct: 599 PPHMGELDQERLTRQQELTALYQM-----QHLQYQQFLIQQQYAQV-----LAQQQKAAL 648

Query: 621 EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER------ 674
              +++  A  +++ +  + +  +   +  + +         + + +    Q        
Sbjct: 649 SSQQQQQLALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGS 708

Query: 675 -----LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQE 729
                L        L + ++ E+ +  + EQERRE E R + R E+ER+  E+ RR+++E
Sbjct: 709 VWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAK-REEEERKRQEELRRQQEE 767

Query: 730 RLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA-ERQLQEEQEKKAKEA 783
            L   R  QE E+  R ++E  +R+ EE  +++ +Q +A  RQ +EE+ ++ +EA
Sbjct: 768 IL---RRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEA 819



 Score = 34.3 bits (77), Expect = 0.55
 Identities = 21/93 (22%), Positives = 50/93 (53%), Gaps = 1/93 (1%)

Query: 675  LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE 734
            L   +EAK  A+Q   ERR +++  Q+R++Q+  +Q++++  +Q  +Q ++++       
Sbjct: 1178 LGDTSEAKEFAKQF-LERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNH 1236

Query: 735  RELQEREKALRLQKEQLQRELEEKKKKEEQQRL 767
              L    +  +   +Q   E  +  KK+++Q++
Sbjct: 1237 STLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKM 1269



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 35/168 (20%), Positives = 73/168 (43%), Gaps = 14/168 (8%)

Query: 17  QKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQD 76
           +K  E L   + +   W  E +EEA+R       +  E   +   ++  RK++ +  VQ 
Sbjct: 834 RKQEELLRKQEEEAAKWARE-EEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE-VQ- 890

Query: 77  ENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATM 136
                 R++   R+ +  Q + RRL+ +   ++LA +   + S   + +   A  + AT+
Sbjct: 891 ------RQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATL 944

Query: 137 ALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVT 184
           +LA       E    L  + E    Q +L+  ++    ++Q  +Q ++
Sbjct: 945 SLAEIQKLEEERERQL--REEQRRQQRELMKALQ---QQQQQQQQKLS 987


>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
          Length = 1299

 Score =  116 bits (291), Expect = 8e-26
 Identities = 93/295 (31%), Positives = 159/295 (53%), Gaps = 36/295 (12%)

Query: 536  EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEV-KLKREERLRKVLQARERVEQMKEE 594
            E+ER+R E LRR++E E LRRQ+ EE KRR  EE+ + K+EE LR+  +    + + +EE
Sbjct: 752  EEERKRQEELRRQQE-EILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREE 810

Query: 595  KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 654
            +++Q      Q +E   + +E R  EE+ +K+         E  RKQEEEA   +W ++E
Sbjct: 811  EERQ------QQEEALRRLEERRREEEERRKQE--------ELLRKQEEEA--AKWAREE 854

Query: 655  EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERRE 714
            EE +R  E  + + EEE  RLR   E ++  E   Q ++E  R+ Q+++E  RR Q+ ++
Sbjct: 855  EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQ-QQ 913

Query: 715  QERQLAE----------QERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 764
            Q++QLA+          Q+      + QA   L E +K L  ++E+  RE E+++++ E 
Sbjct: 914  QQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQK-LEEERERQLRE-EQRRQQREL 971

Query: 765  QRLAERQLQEEQEK-----KAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAP 814
             +  ++Q Q++Q+K        + +G +K+L      ++      Q   Q H+ P
Sbjct: 972  MKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQP 1026



 Score =  114 bits (284), Expect = 5e-25
 Identities = 83/261 (31%), Positives = 147/261 (56%), Gaps = 33/261 (12%)

Query: 542 LENLRRKEEAE--QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQI 599
           LE L++ E+A+  +L +++ E + R + EE + KR+E LR+  Q  E + + +EE++K+ 
Sbjct: 723 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRR--QQEEILRRQQEEERKRR 780

Query: 600 EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 659
           E+      E+  + K+E     + +++ A ++  E E R++QEE  RRL   ++EEEERR
Sbjct: 781 EE------EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 834

Query: 660 HQELLQKKKEE----------------EQERLRKAAEAKRLAEQREQERREQERREQERR 703
            QE L +K+EE                E+ RLR   EA RL  + E+ER+ +E   Q ++
Sbjct: 835 KQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHE-EEERKRKELEVQRQK 893

Query: 704 EQERREQERREQERQLAEQERRRE--QERLQAERELQEREKALRLQKEQLQRELEEKKKK 761
           E  R+ Q+++E  R+L +Q+++++  Q +L +     ++      Q  Q    L E +K 
Sbjct: 894 ELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQ-SQATLSLAEIQKL 952

Query: 762 EEQQRLAERQLQEEQEKKAKE 782
           EE++   ERQL+EEQ ++ +E
Sbjct: 953 EEER---ERQLREEQRRQQRE 970



 Score =  104 bits (259), Expect = 4e-22
 Identities = 71/203 (34%), Positives = 117/203 (57%), Gaps = 25/203 (12%)

Query: 584 ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 643
           A E+++Q+++ K  ++EQ             E R AE +AK++   +K +E E RR+QEE
Sbjct: 722 ALEQLQQLEKAKAAKLEQ-------------ERREAEMRAKREEEERKRQE-ELRRQQEE 767

Query: 644 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERR 703
             RR    Q+EE +RR +E L ++K+EE  R ++  E     ++ E+ER++QE   +   
Sbjct: 768 ILRRQ---QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLE 824

Query: 704 EQERREQERREQERQLAEQERR-----REQERLQAERELQEREKALRLQKEQLQRELEEK 758
           E+ R E+ERR+QE  L +QE       RE+E  +A+R L+E    +  +  +L+ E EE+
Sbjct: 825 ERRREEEERRKQEELLRKQEEEAAKWAREEE--EAQRRLEENRLRMEEEAARLRHEEEER 882

Query: 759 KKKE-EQQRLAERQLQEEQEKKA 780
           K+KE E QR  E   Q +Q+++A
Sbjct: 883 KRKELEVQRQKELMRQRQQQQEA 905



 Score =  100 bits (248), Expect = 8e-21
 Identities = 67/182 (36%), Positives = 111/182 (60%), Gaps = 14/182 (7%)

Query: 606 IDEKTEKAKEERLAE-EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELL 664
           +D  T     E+L + EKAK     ++  E E R K+EEE R+    +QEE  R+ +E+L
Sbjct: 714 LDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERK----RQEELRRQQEEIL 769

Query: 665 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE----RREQERQLA 720
           ++++EEE++R  +   A+R  E+  + +REQE   + +RE+E R+Q+    RR +ER+  
Sbjct: 770 RRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE 829

Query: 721 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 780
           E+ERR+++E L+ + E  E  K  R ++E+ QR LEE + + E++  A R   EE+E+K 
Sbjct: 830 EEERRKQEELLRKQEE--EAAKWAR-EEEEAQRRLEENRLRMEEE--AARLRHEEEERKR 884

Query: 781 KE 782
           KE
Sbjct: 885 KE 886



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 60/240 (25%), Positives = 136/240 (56%), Gaps = 28/240 (11%)

Query: 535  VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 594
            + ++R+  E  +++E   +L  ++ EE++RR+ EE+  K+EE   K   ARE     +EE
Sbjct: 804  LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAK--WARE-----EEE 856

Query: 595  KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 654
             ++++E+   +++E+  + + E   EE+ +K+   ++ +E+  +R+Q++EA  LR LQQ+
Sbjct: 857  AQRRLEENRLRMEEEAARLRHEE--EERKRKELEVQRQKELMRQRQQQQEA--LRRLQQQ 912

Query: 655  EEERRHQELLQKKKEE-------------EQERLRKAAEAKRLAEQREQERREQERREQE 701
            +++   Q+L Q K                + +     AE ++L E+RE++ RE++RR+Q 
Sbjct: 913  QQQ---QQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQR 969

Query: 702  RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK 761
               +  ++Q++++Q++        +     ++  E+Q+ E+A ++QK+Q Q++  ++  +
Sbjct: 970  ELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQ-EEARQMQKQQQQQQQHQQPNR 1028



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 48/133 (36%), Positives = 85/133 (63%), Gaps = 11/133 (8%)

Query: 664 LQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER--REQERREQERREQERQLAE 721
           L+K K  + E+ R+ AE +   E+ E++R+E+ RR+QE   R Q+  E++RRE+E    E
Sbjct: 729 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE----E 784

Query: 722 QERRREQERLQAERELQ-----EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 776
             RR+++E L+ +RE +     +RE+  R Q+E+  R LEE++++EE++R  E  L++++
Sbjct: 785 LARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE 844

Query: 777 EKKAKEAAGASKA 789
           E+ AK A    +A
Sbjct: 845 EEAAKWAREEEEA 857



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 89/407 (21%), Positives = 173/407 (42%), Gaps = 75/407 (18%)

Query: 381  EAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPK-PAASSPETPSAGQQEAKTDQAD- 438
            E +P A+ +P V E  G + W   D  +  +TP P        E   A + E +  +A+ 
Sbjct: 693  ELQPTAS-QPTVWE--GGSVW---DLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEM 746

Query: 439  -GPREPPQSARR---KRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRT 494
               RE  +  R+   +R  ++ +    EE+    EE +  R K   +     +    LR 
Sbjct: 747  RAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRR 806

Query: 495  FLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQL 554
                 +R Q                 +     R++ +    E+ R++ E LR++EE E  
Sbjct: 807  QREEEERQQ-----------------QEEALRRLEERRREEEERRKQEELLRKQEE-EAA 848

Query: 555  RRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 614
            +  + EE+ +RRLEE +L+ EE                                  E A+
Sbjct: 849  KWAREEEEAQRRLEENRLRMEE----------------------------------EAAR 874

Query: 615  EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER 674
                 EE+ +K+   ++ +E+  +R+Q++EA R R  QQ+++++  Q  L       Q+ 
Sbjct: 875  LRHEEEERKRKELEVQRQKELMRQRQQQQEALR-RLQQQQQQQQLAQMKLPSSSTWGQQS 933

Query: 675  LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE 734
               A +++      E ++ E+ER  Q R EQ R+++E      +  +Q+++++Q++L   
Sbjct: 934  NTTACQSQATLSLAEIQKLEEERERQLREEQRRQQREL----MKALQQQQQQQQQKLSGW 989

Query: 735  RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 781
              + +     +   E  Q E  + +K+++QQ+      Q +Q  +A+
Sbjct: 990  GNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQ------QHQQPNRAR 1030



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 112/535 (20%), Positives = 205/535 (38%), Gaps = 101/535 (18%)

Query: 287 PDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEE 346
           PD  +   G +TD   V  S   P + S        S    QE+   +  R+   KT + 
Sbjct: 348 PDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEA--SQFERKDEPKTEQT 405

Query: 347 PAASGRIICHSYLERLLNVEVPQKVGSEQ---------KEPPEEAEPVAAAEPEVPENNG 397
             A       + +E  L  +VP + G E          + P + A P+    P VP    
Sbjct: 406 EKAEEE----TRMENSLPAKVPSR-GDEMVADVQQPLSQIPSDTASPLLILPPPVP---- 456

Query: 398 NNSWPHNDTEIANSTPNPKPAASSPETP-----SAGQQEAKTDQADGPREPPQSARRKRS 452
                           NP P     ETP       G    + D  +G +   Q A +  +
Sbjct: 457 ----------------NPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVA 500

Query: 453 YKQAVSELDEEQHLEDEELQPPRSKTPSSPC------------PASKVVRPLRTFLHTVQ 500
           Y Q  S LD+E+     +LQ  R+K  S P             P  ++  P         
Sbjct: 501 YLQD-SALDDERLAS--KLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFN------- 550

Query: 501 RNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVE 560
            NQ +     A    M   +KR             ++  Q L ++ +             
Sbjct: 551 -NQEMAEWFQAGYFTMSLLVKRAC-----------DESFQPLGDIMKMWGRVPFSPGPAP 598

Query: 561 EDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAE 620
                 L++ +L R++ L  + Q      Q  + ++  I+Q++AQ+      A++++ A 
Sbjct: 599 PPHMGELDQERLTRQQELTALYQM-----QHLQYQQFLIQQQYAQV-----LAQQQKAAL 648

Query: 621 EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER------ 674
              +++  A  +++ +  + +  +   +  + +         + + +    Q        
Sbjct: 649 SSQQQQQLALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGS 708

Query: 675 -----LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQE 729
                L        L + ++ E+ +  + EQERRE E R + R E+ER+  E+ RR+++E
Sbjct: 709 VWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAK-REEEERKRQEELRRQQEE 767

Query: 730 RLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA-ERQLQEEQEKKAKEA 783
            L   R  QE E+  R ++E  +R+ EE  +++ +Q +A  RQ +EE+ ++ +EA
Sbjct: 768 IL---RRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEA 819



 Score = 34.3 bits (77), Expect = 0.55
 Identities = 21/93 (22%), Positives = 50/93 (53%), Gaps = 1/93 (1%)

Query: 675  LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE 734
            L   +EAK  A+Q   ERR +++  Q+R++Q+  +Q++++  +Q  +Q ++++       
Sbjct: 1178 LGDTSEAKEFAKQF-LERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNH 1236

Query: 735  RELQEREKALRLQKEQLQRELEEKKKKEEQQRL 767
              L    +  +   +Q   E  +  KK+++Q++
Sbjct: 1237 STLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKM 1269



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 35/168 (20%), Positives = 73/168 (43%), Gaps = 14/168 (8%)

Query: 17  QKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQD 76
           +K  E L   + +   W  E +EEA+R       +  E   +   ++  RK++ +  VQ 
Sbjct: 834 RKQEELLRKQEEEAAKWARE-EEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE-VQ- 890

Query: 77  ENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATM 136
                 R++   R+ +  Q + RRL+ +   ++LA +   + S   + +   A  + AT+
Sbjct: 891 ------RQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATL 944

Query: 137 ALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVT 184
           +LA       E    L  + E    Q +L+  ++    ++Q  +Q ++
Sbjct: 945 SLAEIQKLEEERERQL--REEQRRQQRELMKALQ---QQQQQQQQKLS 987


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score =  115 bits (289), Expect = 1e-25
 Identities = 83/263 (31%), Positives = 145/263 (55%), Gaps = 26/263 (9%)

Query: 517 KSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 576
           ++ +K NT L+M   CS + K   +        E E+    + E  K R  E  K +RE 
Sbjct: 8   RAAVKLNTELQM-VSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERRER 66

Query: 577 RLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVE 636
             RK    RER ++ K E+ K+        ++K E+ KEER  E K +++    K  E +
Sbjct: 67  EKRK----REREKERKRERGKK--------EKKGERKKEER--ERKKRRREKENKEGEEK 112

Query: 637 ARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQE 696
            +RK++E+  R R  ++ +E  R +E   +K+EE +ER RK        E+RE+ER  +E
Sbjct: 113 EKRKKKEKKERGRTSKEGKERERKEE---RKREERKERERK-------KEEREKERERKE 162

Query: 697 RREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELE 756
           R+++ER++   +E+ER+E+ER+  ++  R  +ER + ERE +ER +  + +K++ +R+ E
Sbjct: 163 RKKRERKQVGEKEEERKEKERKERKKRERNRKER-KKERERKERRERKKERKKKEERKKE 221

Query: 757 EKKKKEEQQRLAERQLQEEQEKK 779
            +K ++   R  ER  +E +E+K
Sbjct: 222 RQKDRQTNWREKERGKRERKERK 244



 Score =  110 bits (276), Expect = 5e-24
 Identities = 70/206 (33%), Positives = 127/206 (61%), Gaps = 12/206 (5%)

Query: 582 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ 641
           ++ RER  + ++E KK+ E +  +   + EK K ER   EK +K+   KK  E +  RK+
Sbjct: 38  IREREREIETRKEGKKERESERKKERREREKRKRER---EKERKRERGKK--EKKGERKK 92

Query: 642 EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 701
           EE  R+ R  ++E +E   +E  +KK+++E+ R  K  + +   E+R++E R++  R++E
Sbjct: 93  EERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE 152

Query: 702 RREQERREQERREQER-QLAEQERRREQ----ERLQAERELQEREKALRLQKEQLQRELE 756
            RE+ER  +ER+++ER Q+ E+E  R++    ER + ER  +ER+K  R +KE+ +R+ E
Sbjct: 153 EREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKE-RERKERRERKKE 211

Query: 757 EKKKKE-EQQRLAERQLQEEQEKKAK 781
            KKK+E +++R  +RQ    ++++ K
Sbjct: 212 RKKKEERKKERQKDRQTNWREKERGK 237



 Score =  108 bits (271), Expect = 2e-23
 Identities = 70/207 (33%), Positives = 132/207 (63%), Gaps = 22/207 (10%)

Query: 576 ERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV 635
           ER R++   +E  ++ + E+KK+  ++        EK K ER   EK +K+   KK  E 
Sbjct: 40  EREREIETRKEGKKERESERKKERRER--------EKRKRER---EKERKRERGKK--EK 86

Query: 636 EARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQ 695
           +  RK+EE  R+ R  ++E+E +  +E  ++KK+E++ER R + E K    +R++ER+ +
Sbjct: 87  KGERKKEERERKKR--RREKENKEGEEKEKRKKKEKKERGRTSKEGKE--RERKEERKRE 142

Query: 696 ERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQREL 755
           ER+E+ER+++E RE+ER  +ER+  E+++  E+E  + E+E +ER+K  R +KE+     
Sbjct: 143 ERKERERKKEE-REKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKER----K 197

Query: 756 EEKKKKEEQQRLAERQLQEEQEKKAKE 782
           +E+++KE ++R  ER+ +EE++K+ ++
Sbjct: 198 KERERKERRERKKERKKKEERKKERQK 224



 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 59/220 (26%), Positives = 126/220 (57%), Gaps = 19/220 (8%)

Query: 596 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 655
           + +I ++  +I+ + E  K+ER +E K +++   K+      +R++E+E +R R  ++++
Sbjct: 35  QSEIREREREIETRKE-GKKERESERKKERREREKR------KREREKERKRERGKKEKK 87

Query: 656 EERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQ 715
            ER+ +E  +KK+  E+E      + KR    +++E++E+ R  +E +E+ER+E   R++
Sbjct: 88  GERKKEERERKKRRREKENKEGEEKEKR----KKKEKKERGRTSKEGKERERKE--ERKR 141

Query: 716 ERQLAEQERRREQERLQAERELQEREKALRLQ---KEQLQRELEEKKKKEEQQRLAERQL 772
           E +   +ER R++E  + ERE +ER+K  R Q   KE+ ++E E K++K+ ++   ER+ 
Sbjct: 142 EER---KERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKK 198

Query: 773 QEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHR 812
           + E++++ +      K      + Q    T+++   +G R
Sbjct: 199 ERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKR 238


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score =  114 bits (286), Expect = 3e-25
 Identities = 73/253 (28%), Positives = 153/253 (60%), Gaps = 17/253 (6%)

Query: 548 KEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQK-- 602
           +E+  Q+R Q+    E++ + R +E +++ +E      Q RE+  QM E++ +  EQ+  
Sbjct: 153 REQEGQVREQEGQVREQEGQVREQEGQVREQEG-----QVREQEGQMGEQEGQMGEQEEQ 207

Query: 603 FAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR-WLQQEEEERRHQ 661
             + +E+ +K +E+   +E+  +K   +  E+ E  +KQEE+ ++    ++++EE+ R Q
Sbjct: 208 MGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQ 267

Query: 662 ELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER-REQERQLA 720
           E   +++EE+  + ++  E +    ++E++ REQE + +E+ EQ R ++E+ REQE Q+ 
Sbjct: 268 EEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMG 327

Query: 721 EQERR---REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQL--QEE 775
           +QE +   ++++  + + ++ ++E+ +  Q+EQ+Q++ E+ +K+EEQ R  E Q+  QEE
Sbjct: 328 KQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEE 387

Query: 776 QEKKAKEAAGASK 788
           Q +K +E  G  K
Sbjct: 388 QMRKQEEQMGEQK 400



 Score =  114 bits (285), Expect = 4e-25
 Identities = 68/242 (28%), Positives = 145/242 (59%), Gaps = 16/242 (6%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
           ++E+ + +  +  E+ EQ+R+Q  EE    + E+V+ + E+  ++  Q R++ EQM+E++
Sbjct: 211 QEEQMQKQEEQMGEQEEQMRKQ--EEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQE 268

Query: 596 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 655
           ++  EQ+   + +K +  +EE+  E++ + +      E+ E  R+QEE+ R     +QEE
Sbjct: 269 EQMREQEEQMLKQKEQTEQEEQTGEQEEQMR------EQEEQMREQEEQMR-----EQEE 317

Query: 656 EERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQ 715
           + R  +E + K++E+  E+  +  E K    ++E++  EQE + Q++ EQ R+++   EQ
Sbjct: 318 QMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQE---EQ 374

Query: 716 ERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEE 775
            R+  EQ R++E++  + E ++ E+++ +  QKEQ++ + E+  +++EQ R  E  + E+
Sbjct: 375 MRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQ 434

Query: 776 QE 777
           +E
Sbjct: 435 KE 436



 Score =  114 bits (284), Expect = 5e-25
 Identities = 75/251 (29%), Positives = 149/251 (59%), Gaps = 20/251 (7%)

Query: 548 KEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQM--KEEKKKQIEQK 602
           +E+  Q+R Q+    E++ + R +E ++  +E      Q  E+ EQM  +EE+ ++ E++
Sbjct: 167 REQEGQVREQEGQVREQEGQVREQEGQMGEQEG-----QMGEQEEQMGEQEEQMQKQEEQ 221

Query: 603 FAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQE 662
             + +E+  K +E+   +E+  +K   +  ++ E  RKQEE+ R     +QEE+ R  +E
Sbjct: 222 MGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMR-----EQEEQMREQEE 276

Query: 663 LLQKKKEEEQERLRKAAEAKRLAEQREQERREQER-REQERREQERREQERREQERQLAE 721
            + K+KE+ ++  +   + +++ EQ EQ R ++E+ REQE + +E+ EQ  +++E+   +
Sbjct: 277 QMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQ 336

Query: 722 QERRREQ--ERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQL--QEEQE 777
           +E+  EQ  +  + E ++ E+E+ ++ Q+EQ++++ E+ +K+EEQ R  E Q+  QEEQ 
Sbjct: 337 KEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQM 396

Query: 778 KKAKEAAGASK 788
            + KE  G  K
Sbjct: 397 GEQKEQMGEQK 407



 Score =  108 bits (271), Expect = 2e-23
 Identities = 68/241 (28%), Positives = 150/241 (62%), Gaps = 23/241 (9%)

Query: 549 EEAEQLRRQKVE----EDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFA 604
           E+ EQ+++Q+ +    E++ R+ EE   ++EE+++K     E+V++ +E+ +KQ EQ   
Sbjct: 210 EQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQK---QEEQVQKQEEQMRKQEEQMRE 266

Query: 605 QIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELL 664
           Q ++  E+  EE++ ++K + +   +  E+ E  R+QEE+ R      ++EE+ R QE  
Sbjct: 267 QEEQMREQ--EEQMLKQKEQTEQEEQTGEQEEQMREQEEQMR------EQEEQMREQEEQ 318

Query: 665 QKKKEEEQERLRKAAEAKRLAEQREQ--ERREQE-RREQERREQERREQERREQERQLAE 721
            +++EE+  +     + +++ EQ+EQ  E++EQ  ++E++  EQE + Q++ EQ R+  E
Sbjct: 319 MREQEEQMGK-----QEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEE 373

Query: 722 QERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 781
           Q R++E++  + E +++++E+ +  QKEQ+  + E+ +++EEQ    + Q+++++E   +
Sbjct: 374 QMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGE 433

Query: 782 E 782
           +
Sbjct: 434 Q 434



 Score =  103 bits (258), Expect = 6e-22
 Identities = 70/247 (28%), Positives = 150/247 (60%), Gaps = 24/247 (9%)

Query: 548 KEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFA 604
           +E+  Q+R Q+    E++ + R +E +++ +E      Q RE+  Q++E++  Q+ ++  
Sbjct: 104 REQEGQVREQEGQVREQEGQVREQEGQVREQEG-----QVREQEGQVREQEG-QVREQEG 157

Query: 605 QIDEKTEKAKEE--RLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQE 662
           Q+ E+  + +E+  ++ E++ + +    ++ E E +  ++E        +QEE+    +E
Sbjct: 158 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMG----EQEEQMGEQEE 213

Query: 663 LLQKKKE---EEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQL 719
            +QK++E   E++E++RK  E  ++ EQ EQ ++++E+ +++  +  ++E++ REQE Q+
Sbjct: 214 QMQKQEEQMGEQEEQMRKQEE--QMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQM 271

Query: 720 AEQERRREQERLQAERELQ--EREKALRLQKEQLQRELEEKKKKEEQQRLAERQL--QEE 775
            EQE +  +++ Q E+E Q  E+E+ +R Q+EQ++ + E+ +++EEQ R  E Q+  QEE
Sbjct: 272 REQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEE 331

Query: 776 QEKKAKE 782
           Q  + KE
Sbjct: 332 QMWEQKE 338



 Score = 96.7 bits (239), Expect = 9e-20
 Identities = 63/246 (25%), Positives = 146/246 (59%), Gaps = 17/246 (6%)

Query: 548 KEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFA 604
           +E+  Q+R Q+    E++ + R +E +++ +E      Q RE+  Q++E++  Q+ ++  
Sbjct: 90  REQEGQVREQEGQVREQEGQVREQEGQVREQEG-----QVREQEGQVREQEG-QVREQEG 143

Query: 605 QIDEKTEKAKEE--RLAEEKAKKKAAAKKMEEVEAR-RKQEEEARRLRWLQQEEEERRHQ 661
           Q+ E+  + +E+  ++ E++ + +    ++ E E + R+QE + R       E+E +  +
Sbjct: 144 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGE 203

Query: 662 ELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQE---RREQERREQERQ 718
           +  Q  ++EEQ + ++    ++  + R+QE +  E+ EQ ++++E   ++E++ R+QE Q
Sbjct: 204 QEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQ 263

Query: 719 LAEQER--RREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 776
           + EQE   R ++E++  ++E  E+E+    Q+EQ++ + E+ +++EEQ R  E Q++E++
Sbjct: 264 MREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQE 323

Query: 777 EKKAKE 782
           E+  K+
Sbjct: 324 EQMGKQ 329



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 67/250 (26%), Positives = 143/250 (57%), Gaps = 25/250 (10%)

Query: 548 KEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFA 604
           +E+  Q+R Q+    E++ + R +E +++ +E      Q RE+  Q++E++  Q+ ++  
Sbjct: 111 REQEGQVREQEGQVREQEGQVREQEGQVREQEG-----QVREQEGQVREQEG-QVREQEG 164

Query: 605 QIDEKTEKAKEE--RLAEEKAKKKAAAKKMEEVEARRKQEEE--ARRLRWLQQEEEERRH 660
           Q+ E+  + +E+  ++ E++ + +    +M E E +  ++EE    +   +Q++EE+   
Sbjct: 165 QVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGE 224

Query: 661 QELLQKKKEE---EQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ-----ER 712
           QE   +K+EE   EQE   +  E +   ++ +  ++E++ REQE + +E+ EQ     E+
Sbjct: 225 QEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQ 284

Query: 713 REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQL 772
            EQE Q  EQE +  ++    E +++E+E+ +R Q+EQ++ + E+  K+EEQ    + Q+
Sbjct: 285 TEQEEQTGEQEEQMREQ----EEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQM 340

Query: 773 QEEQEKKAKE 782
            E++E+  K+
Sbjct: 341 WEQKEQMWKQ 350



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 80/299 (26%), Positives = 165/299 (55%), Gaps = 25/299 (8%)

Query: 535 VEKERQRLENLRRKEEAEQLRRQKVE-----EDKRRRLE--EVKLKREERLRKVL-QARE 586
           +  E  + +N   +EE + +  +K E     ++ +R+LE  ++ L +E ++R+   Q RE
Sbjct: 4   ITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVRE 63

Query: 587 RVEQMKEEKKKQIEQKFAQIDEKTEKAKEE--RLAEEKAKKKAAAKKMEEVEAR-RKQEE 643
           +  Q++E++  Q+ ++  Q+ E+  + +E+  ++ E++ + +    ++ E E + R+QE 
Sbjct: 64  QEGQVREQEG-QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 122

Query: 644 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER--REQER--RE 699
           + R      +E+E +  ++  Q +++E Q R ++    ++  + REQE   REQE   RE
Sbjct: 123 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 182

Query: 700 QER--REQE----RREQERREQERQLAEQE---RRREQERLQAERELQEREKALRLQKEQ 750
           QE   REQE     +E +  EQE Q+ EQE   +++E++  + E +++++E+ +  Q+EQ
Sbjct: 183 QEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQ 242

Query: 751 LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQ 809
           +Q++ E+ +K+EEQ R  E Q++E++E+  ++     K    T   +       QM  Q
Sbjct: 243 VQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQ 301



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 64/254 (25%), Positives = 148/254 (58%), Gaps = 26/254 (10%)

Query: 548 KEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFA 604
           +E+  Q+R Q+    E++ + R +E +++ +E      Q RE+  Q++E++  Q+ ++  
Sbjct: 69  REQEGQVREQEGQVREQEGQVREQEGQVREQEG-----QVREQEGQVREQEG-QVREQEG 122

Query: 605 QIDEKTEKAKEE--RLAEEKAKKKAAAKKMEEVEAR-RKQEEEARRLRWLQQEEEERRHQ 661
           Q+ E+  + +E+  ++ E++ + +    ++ E E + R+QE + R      +E+E +  +
Sbjct: 123 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 182

Query: 662 ELLQKKKEEEQ---ERLRKAAEAKRLAEQREQ-ERREQERREQERR---------EQERR 708
           +  Q +++E Q   +  +   + +++ EQ EQ +++E++  EQE +         EQE +
Sbjct: 183 QEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQ 242

Query: 709 EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA 768
            Q++ EQ ++  EQ R++E++  + E +++E+E+ +  QKEQ ++E E+  ++EEQ R  
Sbjct: 243 VQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQE-EQTGEQEEQMREQ 301

Query: 769 ERQLQEEQEKKAKE 782
           E Q++E++E+  ++
Sbjct: 302 EEQMREQEEQMREQ 315



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 66/357 (18%), Positives = 149/357 (41%), Gaps = 27/357 (7%)

Query: 325 VAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGS---EQKEPPEE 381
           V +QE  VR    ++ ++  +     G++       R    +V ++ G    ++ +  E+
Sbjct: 89  VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 148

Query: 382 AEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPR 441
              V   E +V E  G                  +      +    G+QE +  + +   
Sbjct: 149 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQM 208

Query: 442 EPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQR 501
              +   +K+  ++ + E +E+   ++E++     +         K    +R      ++
Sbjct: 209 GEQEEQMQKQ--EEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMR------KQ 260

Query: 502 NQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEE 561
            + +       R   +  +K+      + +    E++ +  E   R++E EQ+R Q   E
Sbjct: 261 EEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQE-EQMREQ---E 316

Query: 562 DKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEE 621
           ++ R  EE   K+EE++    + +E++ + KE+  KQ EQ   Q ++  ++ ++ R  EE
Sbjct: 317 EQMREQEEQMGKQEEQM---WEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEE 373

Query: 622 KAKKKAAAKKMEEVEARRKQEEE--------ARRLRWLQQEEEERRHQELLQKKKEE 670
           + +K+    + +E E  RKQEE+          +   ++++EE+   Q+   +K+EE
Sbjct: 374 QMRKQEEQMRKQE-EQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEE 429



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 75/397 (18%), Positives = 161/397 (40%), Gaps = 66/397 (16%)

Query: 325 VAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGS---EQKEPPEE 381
           V +QE  VR    ++ ++  +     G++       R    +V ++ G    ++ +  E+
Sbjct: 103 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 162

Query: 382 AEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPR 441
              V   E +V E  G                  +      +    G+QE +  + +   
Sbjct: 163 EGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQM 222

Query: 442 EPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQR 501
              +   RK+  ++ + E +E+   ++E++Q    +         +    +R      Q 
Sbjct: 223 GEQEEQMRKQ--EEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMRE-----QE 275

Query: 502 NQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEE 561
            QML       +       ++   +R   +    ++E+ R +  + +E+ EQ+ +Q  EE
Sbjct: 276 EQMLKQKEQTEQEEQTG--EQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQ--EE 331

Query: 562 DKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEE 621
               + E++  ++E+  ++  Q  E+ EQM+++                         EE
Sbjct: 332 QMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQ-------------------------EE 366

Query: 622 KAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEA 681
           + +K        + E  RKQEE+ R+     QEE+ R+ +E + ++KE+           
Sbjct: 367 QVRK--------QEEQMRKQEEQMRK-----QEEQMRKQEEQMGEQKEQ----------- 402

Query: 682 KRLAEQREQERREQERREQERREQERREQERREQERQ 718
             + EQ+EQ  REQE +  E++EQ R+++E   ++++
Sbjct: 403 --MGEQKEQ-MREQEEQMGEQKEQMRKQEEHMGEQKE 436


>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
           theta, 150/170kDa [Homo sapiens]
          Length = 1382

 Score =  112 bits (279), Expect = 2e-24
 Identities = 99/373 (26%), Positives = 184/373 (49%), Gaps = 64/373 (17%)

Query: 464 QHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRN 523
           Q +  E+++   +   S    A +V++P        +++Q+ +T      + +K+  K +
Sbjct: 512 QSMPSEQIRNQLTAMSSVLAKALEVIKPAHILQEKEEQHQLAVT------AYLKNSRKEH 565

Query: 524 TPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR---K 580
              R+  +   +E+ ++RLE+L  + E E+L +++ E  K R+ EE +L++E + R   +
Sbjct: 566 Q--RILARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKER 623

Query: 581 VLQARERV------EQMKEEKKKQIEQK-FAQID--------------------EKTEKA 613
           +LQ  E++      E++++ KK ++  K F  ID                    EK +K 
Sbjct: 624 ILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKE 683

Query: 614 KEERLA--EEKAKKKAAAKKMEEVEARRKQEEEARRLR---WLQQEEEERRHQELLQKKK 668
            +ERL   E+K      AK++EE+   +   EE R      W QQEEE     +L ++K 
Sbjct: 684 LQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTMQLEREKA 743

Query: 669 EEEQERLRKAAEAKRL----------------AEQREQERREQERREQERREQERREQER 712
            E + R+ +  E + L                 +Q E+   E+     E R+++R+E+ R
Sbjct: 744 LEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERR 803

Query: 713 REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQL 772
               R+  E+E+RR +E++  ERE  ERE+A R ++E+  RE +E+ KK E+    +RQ 
Sbjct: 804 ITYYREKEEEEQRRAEEQMLKERE--ERERAERAKREEELREYQERVKKLEEVERKKRQR 861

Query: 773 Q---EEQEKKAKE 782
           +   EE+E++ +E
Sbjct: 862 ELEIEERERRREE 874



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 81/316 (25%), Positives = 153/316 (48%), Gaps = 77/316 (24%)

Query: 537 KERQRLENLRRKEEAEQLRRQKVEED---KRRRLEEVKLKR----EERLRKV----LQAR 585
           K+ ++LE   +KE  E+L+ Q+ + D   + +RLEE+ L +    E+R++ +     Q  
Sbjct: 672 KQVEQLEK-EKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEE 730

Query: 586 ERVEQMKEEKKKQIEQK--FAQIDEKTE------KAKEERLAEEKAKK---KAAAKKMEE 634
           ER+  M+ E++K +E K   +++ E  +      KA  + + EEK K+   + A ++   
Sbjct: 731 ERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNR 790

Query: 635 VEARRKQEEEARRLRWLQQ--EEEERRHQELLQKKKEEE---------------QERLRK 677
           +E R++Q +E RR+ + ++  EEE+RR +E + K++EE                QER++K
Sbjct: 791 LEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVKK 850

Query: 678 AAEAKRLAEQREQERREQERREQERR-----------------------------EQERR 708
             E +R   QRE E  E+ERR +E R                             + E R
Sbjct: 851 LEEVERKKRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWR 910

Query: 709 ----EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQR----ELEEKKK 760
               E+E R  E +  ++  RR++ER +   + ++RE +LR   +++ R    +    ++
Sbjct: 911 RGPPEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSLRPDDDRVPRRGMDDDRGPRR 970

Query: 761 KEEQQRLAERQLQEEQ 776
             E+ R + R   +++
Sbjct: 971 GPEEDRFSRRGADDDR 986



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 38/187 (20%), Positives = 79/187 (42%), Gaps = 21/187 (11%)

Query: 611  EKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE 670
            EKA+EE     +  + +  ++ +    R K+ +   + R    ++ ER         +E+
Sbjct: 1182 EKAREESWGPPRESRPSEEREWD----REKERDRDNQDREENDKDPERERDRERDVDRED 1237

Query: 671  EQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERRE--QERQLAEQERRREQ 728
               R R     +R   +     R+  RR+   R+  RRE++ R   +ER+    +R R  
Sbjct: 1238 RFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRG 1297

Query: 729  ERLQAERE---------------LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQ 773
              L++ERE               ++ER+   R+    L R+ E  + +E +    +   +
Sbjct: 1298 PPLRSEREEVSSWRRADDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEKEKASWR 1357

Query: 774  EEQEKKA 780
             E+++++
Sbjct: 1358 AEKDRES 1364



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 37/135 (27%), Positives = 70/135 (51%), Gaps = 23/135 (17%)

Query: 663 LLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQ 722
           +LQ+K+E+ Q  +    +  R   QR   RR+     +ER E    ++E+ E E      
Sbjct: 542 ILQEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELE------ 595

Query: 723 ERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK---EEQQRLAERQLQE--EQE 777
                    Q E ELQ+  KA   ++E+L++E +E++K+   +E +++ ++ ++E  EQ 
Sbjct: 596 ---------QREAELQKVRKA---EEERLRQEAKEREKERILQEHEQIKKKTVRERLEQI 643

Query: 778 KKAKEAAGASKALNV 792
           KK +  A A K +++
Sbjct: 644 KKTELGAKAFKDIDI 658



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 44/197 (22%), Positives = 88/197 (44%), Gaps = 12/197 (6%)

Query: 536  EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
            EKE+ R E+     E+     ++ + +K R  +     REE  +   + R+R      E+
Sbjct: 1180 EKEKAREESWGPPRESRPSEEREWDREKER--DRDNQDREENDKDPERERDR------ER 1231

Query: 596  KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKME-EVEARRKQEEEARRLRWLQQE 654
                E +F +   + E       AEE +  + ++++ + + + RR++ ++ R LR  +  
Sbjct: 1232 DVDREDRFRR--PRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDL 1289

Query: 655  EEERRHQELLQKKKEEEQERLRKAAEAK-RLAEQREQERREQERREQERREQERREQERR 713
             ++R  +    + + EE    R+A + K    E+R+  RR         RE++R  +   
Sbjct: 1290 RDDRDRRGPPLRSEREEVSSWRRADDRKDDRVEERDPPRRVPPPALSRDRERDRDREREG 1349

Query: 714  EQERQLAEQERRREQER 730
            E+E+     E+ RE  R
Sbjct: 1350 EKEKASWRAEKDRESLR 1366



 Score = 37.4 bits (85), Expect = 0.065
 Identities = 48/198 (24%), Positives = 85/198 (42%), Gaps = 29/198 (14%)

Query: 575  EERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEE 634
            EER     + R+R  Q +EE  K  E+   + D + +  +E+R    +          +E
Sbjct: 1199 EEREWDREKERDRDNQDREENDKDPER---ERDRERDVDREDRFRRPR----------DE 1245

Query: 635  VEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE--- 691
               RR   EE+   R     +  RR       ++ E  +R R   E + L + R++    
Sbjct: 1246 GGWRRGPAEESSSWR-----DSSRRDDRDRDDRRRERDDR-RDLRERRDLRDDRDRRGPP 1299

Query: 692  -RREQERREQERREQERREQ--ERREQERQLAEQERRREQER-LQAERELQEREKALRLQ 747
             R E+E     RR  +R++   E R+  R++      R++ER    ERE ++ + + R +
Sbjct: 1300 LRSEREEVSSWRRADDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAE 1359

Query: 748  KEQLQRELEEKKKKEEQQ 765
            K+   RE   + K E  +
Sbjct: 1360 KD---RESLRRTKNETDE 1374



 Score = 37.0 bits (84), Expect = 0.084
 Identities = 24/139 (17%), Positives = 60/139 (43%), Gaps = 11/139 (7%)

Query: 640  KQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE 699
            +++E+AR   W    E     +    ++KE +++            + RE+  ++ ER  
Sbjct: 1179 REKEKAREESWGPPRESRPSEEREWDREKERDRDN-----------QDREENDKDPERER 1227

Query: 700  QERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKK 759
               R+ +R ++ RR ++     +    E    +      +R++  R ++   +R+L E++
Sbjct: 1228 DRERDVDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERR 1287

Query: 760  KKEEQQRLAERQLQEEQEK 778
               + +      L+ E+E+
Sbjct: 1288 DLRDDRDRRGPPLRSEREE 1306


>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 523

 Score =  112 bits (279), Expect = 2e-24
 Identities = 112/385 (29%), Positives = 194/385 (50%), Gaps = 45/385 (11%)

Query: 409 ANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLED 468
           A +    K   SSP+T ++G   +  D A G             Y +  +     + LE 
Sbjct: 42  AGANRKKKINGSSPDTATSGGYHSPGDSATG------------IYGEGRASSTTLEDLES 89

Query: 469 EELQPPRSKTPSSPCPASKVVRPLRTFLHTV--QRNQMLMTPTSAPRSVMKSFIKRNTPL 526
           +  Q       SS    S++   + + + T   ++   +       RS+ K   +   PL
Sbjct: 90  Q-YQELAVALDSSSAIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPL 148

Query: 527 RMDPKCSFVEKERQRLENLRRKEEAEQLRRQ-KVEEDKRRRLEEVKLKREERLRKVLQA- 584
             +P     + E+ + E    ++E E + RQ + E +  + L  +  ++EERLR+  +  
Sbjct: 149 APEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERL 208

Query: 585 RERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE 644
           RE+ E+++E++++  EQ      E+  + +EERL E++ +     +++ E E R  ++EE
Sbjct: 209 REQEERLREQEERLCEQ------EERLREQEERLREQEERLCEQEERLREHEERLCEQEE 262

Query: 645 ARRLRWLQQEEEERRHQELLQKKKE---EEQERLRKAAEAKRLAEQREQERREQERR--- 698
               R  +QEE  R  +E L +++E   E++ERLR+  E  RL EQ E+  REQE R   
Sbjct: 263 ----RLCEQEERLREQEERLHEQEERLCEQEERLREQEE--RLCEQ-EERLREQEERLCE 315

Query: 699 -EQERREQERR--EQERRE-QERQLAEQERRREQERLQAERE-LQEREKALRLQKEQLQR 753
            E+  REQE R  EQE+   QER L E E+  EQER Q E+E L ERE+ L    E+++ 
Sbjct: 316 QEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLL----EEVEE 371

Query: 754 ELEEKKKKEEQQRLAERQLQEEQEK 778
            LE+++ +++ +RL +++  +E E+
Sbjct: 372 LLEQERLRQQDERLWQQETLQELER 396



 Score =  100 bits (249), Expect = 6e-21
 Identities = 101/365 (27%), Positives = 175/365 (47%), Gaps = 38/365 (10%)

Query: 466 LEDEELQPPRSKTPSSPCPASKV---VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKR 522
           L+++  +P   + P+ P    ++      LR  L +V R            + M S + R
Sbjct: 140 LKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQ----AEVENNQMLSLLNR 195

Query: 523 NTPLRMDPKCSFVEKERQRLENLRRKEE--AEQLRRQKVEEDKRRRLEEVKLKREERLRK 580
               R+  +    E+ R++ E LR +EE   EQ  R + +E++ R  EE   ++EERLR 
Sbjct: 196 RQEERLREQ---EERLREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLR- 251

Query: 581 VLQARERVEQMKEEKKKQIEQKFAQIDEKTEKA--KEERLAEEKAKKKAAAKKMEEVEAR 638
                E  E++ E++++  EQ+  ++ E+ E+   +EERL E++ + +   +++ E E R
Sbjct: 252 -----EHEERLCEQEERLCEQE-ERLREQEERLHEQEERLCEQEERLREQEERLCEQEER 305

Query: 639 RKQEEEARRLRWLQQEEEERRHQE-LLQKKKEEEQERLRKAAEAKRLAEQREQERRE--- 694
            +++EE    R  +QEE  R  +E L +++K   QERL +  E K L ++R QE +E   
Sbjct: 306 LREQEE----RLCEQEERLREQEERLCEQEKLPGQERLLEEVE-KLLEQERRQEEQERLL 360

Query: 695 ------QERREQERREQERREQERREQERQLAEQERRREQERL--QAERELQEREKALRL 746
                 +E  E   +E+ R++ ER  Q+  L E ER RE ER+       L E+    R 
Sbjct: 361 ERERLLEEVEELLEQERLRQQDERLWQQETLQELERLRELERMLELGWEALYEQRAEPRS 420

Query: 747 QKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQM 806
             E+L  E +   + E+Q +  ++    E+ + ++ AA A       V   +  C     
Sbjct: 421 GFEELNNENKSTLQLEQQVKELKKSGGAEEPRGSESAAAARPVAGAPVPQGAWMCGQAGW 480

Query: 807 TPQGH 811
           TPQ H
Sbjct: 481 TPQEH 485



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 80/263 (30%), Positives = 145/263 (55%), Gaps = 26/263 (9%)

Query: 528 MDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR-E 586
           +D   + + +  + + +L R  + E+     + +   R L ++K +  E L     A   
Sbjct: 98  LDSSSAIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPS 157

Query: 587 RVEQMKEEK---KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 643
           +VEQ+++E    +K++E    Q+  + E  +   L   + +++     + E E R +++E
Sbjct: 158 KVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEER-----LREQEERLREQE 212

Query: 644 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR-EQER 702
           E  RLR    E+EER  ++  +++  E++ERLR+  E  RL EQ E+ R  +ER  EQE 
Sbjct: 213 E--RLR----EQEERLCEQ--EERLREQEERLREQEE--RLCEQEERLREHEERLCEQEE 262

Query: 703 REQERREQERREQERQLAEQERR--REQERLQAERE-LQEREKALRLQKEQLQRELEEKK 759
           R  E+ E+  REQE +L EQE R   ++ERL+ + E L E+E+ LR Q+E+L  +  E++
Sbjct: 263 RLCEQ-EERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQ--EER 319

Query: 760 KKEEQQRLAERQLQEEQEKKAKE 782
            +E+++RL E++    QE+  +E
Sbjct: 320 LREQEERLCEQEKLPGQERLLEE 342


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score =  111 bits (278), Expect = 3e-24
 Identities = 75/268 (27%), Positives = 149/268 (55%), Gaps = 48/268 (17%)

Query: 517 KSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 576
           ++ +K NT L+M   CS + K   + E+ R+KE  E+ +R++  E +R+R         E
Sbjct: 8   RAAVKLNTELQM-VSCSHISKPCTQRESERKKERREREKRKREREKERKR---------E 57

Query: 577 RLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVE 636
           R +K  + R++ E+ KE ++K+ E+         EK ++ER  +E+ K+K   KK E  +
Sbjct: 58  RGKKEKKKRKKRERGKERERKRKER---------EKQRKERREKERRKRKKEKKKRERKQ 108

Query: 637 ARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQE 696
             R++                       +KKK+E +ER R   E K+  E++ ++RR+++
Sbjct: 109 RGRRE-----------------------RKKKKERKERER---ENKQRRERKRKKRRKKK 142

Query: 697 RREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELE 756
           RR++ +RE+ER ++ER+ ++R+  E+E++RE+ R + ++E + +E+  R ++ + +R   
Sbjct: 143 RRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKER--- 199

Query: 757 EKKKKEEQQRLAERQLQEEQEKKAKEAA 784
            KKK+ ++ R  +RQ   +  +  +E+A
Sbjct: 200 RKKKERKKDRKTDRQTDSQVFRPLRESA 227



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 32/122 (26%), Positives = 67/122 (54%), Gaps = 1/122 (0%)

Query: 527 RMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARE 586
           R + K     KER+R    RR+ + ++ R++K  ++++R  E  K +R+ + RK  +  +
Sbjct: 111 RRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREK 170

Query: 587 RVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEAR 646
           + E+ ++E+KK+ E+K  + + K E+ KE R  +E+ K +   ++ +    R  +E    
Sbjct: 171 KRERNRKERKKERERKERR-ERKKERKKERRKKKERKKDRKTDRQTDSQVFRPLRESAFN 229

Query: 647 RL 648
           R+
Sbjct: 230 RV 231


>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score =  110 bits (275), Expect = 6e-24
 Identities = 80/299 (26%), Positives = 166/299 (55%), Gaps = 20/299 (6%)

Query: 532 CSFVEKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERLR----KVLQAR 585
           C    K R++ E + R+EE    + +K+  +EDK  R EE   ++EE++R    K+ +  
Sbjct: 314 CEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQE 373

Query: 586 ERVEQMKEEKKKQIEQKFAQ---IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQE 642
           E++ +  E+ ++Q E+ + Q   I E+ EK +E+   +EK  ++   K  E+ E   +QE
Sbjct: 374 EKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQE 433

Query: 643 EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER 702
           E+ R L  + Q++EE+  +  +++K +EE+E++++  E  +  E++ QE+ E+  R+++ 
Sbjct: 434 EKIRELEEMMQDQEEKLRE--VEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKL 491

Query: 703 REQERR--EQER---REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 757
            +QE +  EQE    R++E+   ++E+ +EQE     +E + RE+ +RL +++ + + +E
Sbjct: 492 LKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQE 551

Query: 758 KKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVT----VDVQSPACTSYQMTPQGHR 812
            + +E ++RL +   + E    A   +G+ +   +T    V+++S    S Q     +R
Sbjct: 552 VRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYR 610



 Score =  107 bits (267), Expect = 5e-23
 Identities = 71/255 (27%), Positives = 156/255 (61%), Gaps = 15/255 (5%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQMK 592
           ++E+   + L+ +E+ E++ RQ+    E++++ R +E K+ R+E   K+ +  E++ + +
Sbjct: 309 QEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEE--KIREQEEKIREQE 366

Query: 593 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV-EARRKQEEEARRLRWL 651
           E+  +Q E+K  + DEK ++ +EE   +E+  ++   K+ E++    +K  E+  ++R  
Sbjct: 367 EKMWRQ-EEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIR-- 423

Query: 652 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 711
           +QEEE  R +E +++ +E  Q++  K  E +   ++ E++ +EQE + Q R+E++ +EQE
Sbjct: 424 EQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQ-RQEEKIQEQE 482

Query: 712 RR--EQERQLAEQERRREQER--LQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRL 767
            +   QE+ L ++E+  EQE    + E ++ E+E+ ++ Q+E++QR+ EEK +++E +  
Sbjct: 483 EKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQ-EEKMREQEVRLW 541

Query: 768 AERQLQEEQEKKAKE 782
            + +  +EQE + +E
Sbjct: 542 QQEEKMQEQEVRLQE 556



 Score =  105 bits (262), Expect = 2e-22
 Identities = 78/270 (28%), Positives = 162/270 (60%), Gaps = 27/270 (10%)

Query: 528 MDPKCSFVEKERQRLE----NLRRKEEAEQL----RRQKVEEDKR-RRLEEVKLKREERL 578
           +  K   VE E+  ++    +L+RK E  QL    ++ +VE D+  + L+ V  K + ++
Sbjct: 223 LQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQV 282

Query: 579 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR 638
            +  +    + Q +EEK  + E+K  + +EK  + +E ++ E++ K     +KM E E +
Sbjct: 283 EEN-ELWNLLNQQQEEKMWRQEEKIQEQEEKMCE-QELKIREQEEKMWRQEEKMHEQEEK 340

Query: 639 RKQEEEARRLRWLQQEEEERRHQELLQKKKEE---EQERLRKAAEAKRLAEQREQERREQ 695
            +++E+    +  +QEE+ R  +E +++++E+   ++E++R+  E  ++ EQ E+  R++
Sbjct: 341 IREQED----KMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDE--KIQEQEEEMWRQE 394

Query: 696 ER-REQERREQE---RREQERREQERQLAEQER---RREQERLQAERELQEREKALRLQK 748
           E+ REQE + QE   R+E++ REQ+ ++ EQE    R+E++  + E  +Q++E+ LR  +
Sbjct: 395 EKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454

Query: 749 EQLQRELEEKKKKEEQQRLAERQLQEEQEK 778
           E++Q E E+ +++EE+ +  E ++QE++EK
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQEEKIQEQEEK 484



 Score =  105 bits (261), Expect = 3e-22
 Identities = 70/259 (27%), Positives = 154/259 (59%), Gaps = 16/259 (6%)

Query: 539 RQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERLRKVLQA-RERVEQM--KE 593
           +Q+ E + R+EE  Q + +K+  +E K R  EE   ++EE++ +  +  RE+ ++M  +E
Sbjct: 293 QQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQE 352

Query: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ 653
           EK ++ E+K  + +EK  + +EE++ E+  K +   ++M   E + +++EE R+ +  +Q
Sbjct: 353 EKIREQEEKIREQEEKMWR-QEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411

Query: 654 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE--QERREQE 711
           E++ R   E +++++EE   +  K  E + + + +E++ RE E + QE  E  QE+ E+ 
Sbjct: 412 EKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI 471

Query: 712 RREQERQLAEQERRREQERL--------QAERELQEREKALRLQKEQLQRELEEKKKKEE 763
           +R++E+   ++E+   QE+L        + E ++  +E+ +  Q+E++Q + E+ +++EE
Sbjct: 472 QRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEE 531

Query: 764 QQRLAERQLQEEQEKKAKE 782
           + R  E +L +++EK  ++
Sbjct: 532 KMREQEVRLWQQEEKMQEQ 550



 Score =  103 bits (256), Expect = 1e-21
 Identities = 70/252 (27%), Positives = 151/252 (59%), Gaps = 12/252 (4%)

Query: 538 ERQRLENLRRKEEAEQLRRQ--KVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
           E   L NL  +++ E++ RQ  K++E + +  E+ +LK  E+  K+ +  E++ + +EEK
Sbjct: 283 EENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQ-ELKIREQEEKMWRQEEKMHE-QEEK 340

Query: 596 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA--RRLRWLQQ 653
            ++ E K  + +EK  + +EE++ E++ K     +K+ E + + +++EE   R+   +++
Sbjct: 341 IREQEDKMWRQEEKIRE-QEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399

Query: 654 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR-EQER 712
           +EE+R+ +   Q+KK  EQ+   K  E +    ++E++ RE E   Q++ E+ R  E++ 
Sbjct: 400 QEEKRQEKMWRQEKKMREQD--EKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKM 457

Query: 713 REQERQLAEQERR--REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAER 770
           +E+E ++ EQE +  R++E++Q + E   R++ L  Q+E++  + E+  ++EE+    E 
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEE 517

Query: 771 QLQEEQEKKAKE 782
           ++QE++EK  ++
Sbjct: 518 KMQEQEEKMQRQ 529



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 74/290 (25%), Positives = 154/290 (53%), Gaps = 21/290 (7%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEE--DKRRRLEEVKLKREERLRKVLQARERVEQMKE 593
           EK R++ E +R +EE    + +K+ E  +K +  EE   ++EE++R+  + R+     +E
Sbjct: 353 EKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQE 412

Query: 594 EKKKQIEQKFAQIDEKT----EKAKE--ERLAEEKAKKKAAAKKMEEVEARRKQEEEA-- 645
           +K ++ ++K  + +E+     EK +E  E + +++ K +   +KM+E E + +++EE   
Sbjct: 413 KKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQ 472

Query: 646 RRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ 705
           R+   +Q++EE+   QE L K++E+  E      + +++  Q E+   ++E+ +++  + 
Sbjct: 473 RQEEKIQEQEEKTWRQEKLLKQEEKIWE------QEEKMWRQEEKMWEQEEKMQEQEEKM 526

Query: 706 ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 765
           +R+E++ REQE +L +QE + +++ ++ + EL+ER   L  QK +L   L    ++   Q
Sbjct: 527 QRQEEKMREQEVRLWQQEEKMQEQEVRLQ-ELEERLGKLG-QKAEL---LGGAGRESGSQ 581

Query: 766 RLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPP 815
           RL       + E K++EA    +  +           +YQ    G  A P
Sbjct: 582 RLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYVAAYQQLASGKEALP 631



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 68/350 (19%), Positives = 153/350 (43%), Gaps = 51/350 (14%)

Query: 435 DQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRT 494
           D+ D   E   S + K S K+    L +++ +ED  +   +  +        K    +  
Sbjct: 85  DEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNE 144

Query: 495 FLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQL 554
             +T ++  ++  P      V       N+ L          +    +E L ++ +A  L
Sbjct: 145 KNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAPSL 204

Query: 555 R--RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEK 612
              R  + +++   L+E   + +E+LR V   +  ++   ++ K+++E+    + ++  +
Sbjct: 205 ELYRNTITDEE---LKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQ 261

Query: 613 AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ 672
            + +RL +E          ++ V A+            LQ + EE     LL +++EE+ 
Sbjct: 262 VEADRLGKE----------LQSVSAK------------LQAQVEENELWNLLNQQQEEKM 299

Query: 673 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 732
            R                  +E++ +EQE +  E+  + R ++E+   ++E+  EQE   
Sbjct: 300 WR------------------QEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEE-- 339

Query: 733 AERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
              +++E+E  +  Q+E++ RE EEK +++E++   + +   EQ++K +E
Sbjct: 340 ---KIREQEDKMWRQEEKI-REQEEKIREQEEKMWRQEEKIREQDEKIQE 385



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 67/323 (20%), Positives = 142/323 (43%), Gaps = 23/323 (7%)

Query: 338 RLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNG 397
           RL K+     A     +  + L  LLN +  +K+  ++++  E+ E +   E ++ E   
Sbjct: 266 RLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQE- 324

Query: 398 NNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRK----RSY 453
              W   +          +      E     Q+E   +Q +  RE  +   R+    R  
Sbjct: 325 EKMWRQEE-----KMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQ 379

Query: 454 KQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPR 513
            + + E +EE   ++E+++    K         K +R     +   ++ + +       R
Sbjct: 380 DEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIR--EQEEEMWRQEEKIR 437

Query: 514 SVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLK 573
            + +    +   LR        EK ++  E ++ +EE  Q + +K++E + +   + KL 
Sbjct: 438 ELEEMMQDQEEKLR-----EVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLL 492

Query: 574 REERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKME 633
           ++E   K+ +  E++ + +EEK  + E+K  + +EK ++ +EE++ E++ +     +KM+
Sbjct: 493 KQEE--KIWEQEEKMWR-QEEKMWEQEEKMQEQEEKMQR-QEEKMREQEVRLWQQEEKMQ 548

Query: 634 EVEARRKQEEEARRLRWLQQEEE 656
           E E R ++ EE  RL  L Q+ E
Sbjct: 549 EQEVRLQELEE--RLGKLGQKAE 569



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 58/257 (22%), Positives = 111/257 (43%), Gaps = 21/257 (8%)

Query: 560 EEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEK----TEKAKE 615
           +ED        KL+++ ++R     + R + + +EK  Q+ +  A ++ +    T++  E
Sbjct: 27  DEDSDLDFHINKLEQQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTKRWDE 86

Query: 616 ERLAEEKAKKKAAAKKMEEVEARRKQE---EEARRLRWLQQEEEERRHQELLQKKKEEEQ 672
           +   EE    K   + ++ V      +   E+A      +  +E +   +  Q+K  E+ 
Sbjct: 87  DDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNEKN 146

Query: 673 ERLRKAAEAK----RLAEQREQERREQERREQ----ERREQERREQERREQERQLAEQER 724
              RK    K    RL E   Q+R E    E+    +   +     E+  +ER     E 
Sbjct: 147 YTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLEL 206

Query: 725 RR----EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEE--QQRLAERQLQEEQEK 778
            R    ++E  +   ELQE+ + +  +K ++Q  +++ K+K E  Q  L ++QLQ E ++
Sbjct: 207 YRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADR 266

Query: 779 KAKEAAGASKALNVTVD 795
             KE    S  L   V+
Sbjct: 267 LGKELQSVSAKLQAQVE 283


>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score =  110 bits (275), Expect = 6e-24
 Identities = 80/299 (26%), Positives = 166/299 (55%), Gaps = 20/299 (6%)

Query: 532 CSFVEKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERLR----KVLQAR 585
           C    K R++ E + R+EE    + +K+  +EDK  R EE   ++EE++R    K+ +  
Sbjct: 314 CEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQE 373

Query: 586 ERVEQMKEEKKKQIEQKFAQ---IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQE 642
           E++ +  E+ ++Q E+ + Q   I E+ EK +E+   +EK  ++   K  E+ E   +QE
Sbjct: 374 EKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQE 433

Query: 643 EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER 702
           E+ R L  + Q++EE+  +  +++K +EE+E++++  E  +  E++ QE+ E+  R+++ 
Sbjct: 434 EKIRELEEMMQDQEEKLRE--VEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKL 491

Query: 703 REQERR--EQER---REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 757
            +QE +  EQE    R++E+   ++E+ +EQE     +E + RE+ +RL +++ + + +E
Sbjct: 492 LKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQE 551

Query: 758 KKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVT----VDVQSPACTSYQMTPQGHR 812
            + +E ++RL +   + E    A   +G+ +   +T    V+++S    S Q     +R
Sbjct: 552 VRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYR 610



 Score =  107 bits (267), Expect = 5e-23
 Identities = 71/255 (27%), Positives = 156/255 (61%), Gaps = 15/255 (5%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQMK 592
           ++E+   + L+ +E+ E++ RQ+    E++++ R +E K+ R+E   K+ +  E++ + +
Sbjct: 309 QEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEE--KIREQEEKIREQE 366

Query: 593 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV-EARRKQEEEARRLRWL 651
           E+  +Q E+K  + DEK ++ +EE   +E+  ++   K+ E++    +K  E+  ++R  
Sbjct: 367 EKMWRQ-EEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIR-- 423

Query: 652 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 711
           +QEEE  R +E +++ +E  Q++  K  E +   ++ E++ +EQE + Q R+E++ +EQE
Sbjct: 424 EQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQ-RQEEKIQEQE 482

Query: 712 RR--EQERQLAEQERRREQER--LQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRL 767
            +   QE+ L ++E+  EQE    + E ++ E+E+ ++ Q+E++QR+ EEK +++E +  
Sbjct: 483 EKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQ-EEKMREQEVRLW 541

Query: 768 AERQLQEEQEKKAKE 782
            + +  +EQE + +E
Sbjct: 542 QQEEKMQEQEVRLQE 556



 Score =  107 bits (266), Expect = 7e-23
 Identities = 101/403 (25%), Positives = 201/403 (49%), Gaps = 62/403 (15%)

Query: 435 DQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRT 494
           D+ D   E   S + K S K+    L +++ +ED  +   +  +        K    +  
Sbjct: 85  DEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNE 144

Query: 495 FLHTVQRNQMLMTP-------TSAPR---SVMKSFIKRNTPLRMDPKCSFVEKERQRL-- 542
             +T ++  ++  P       T+  R   S+++  +  +  +RM      + KER  L  
Sbjct: 145 KNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSL 204

Query: 543 ---------ENLRRKEEAEQLRRQKVEEDK----------RRRLEEVKL--------KRE 575
                    E L+ K    Q + + VE +K          +R+LE  +L           
Sbjct: 205 ELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEA 264

Query: 576 ERLRKVLQARERVEQMKEEK-------KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAA 628
           +RL K LQ+     Q + E+        +Q E+K  + +EK ++ +EE++ E++ K +  
Sbjct: 265 DRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQE-QEEKMCEQELKIREQ 323

Query: 629 AKKMEEVEARRKQEEEARRL---RWLQQEEEERRHQELLQKKKEE---EQERLRKAAEAK 682
            +KM   E +  ++EE  R    +  +QEE+ R  +E +++++E+   ++E++R+  E  
Sbjct: 324 EEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDE-- 381

Query: 683 RLAEQREQERREQER-REQERREQE---RREQERREQERQLAEQER---RREQERLQAER 735
           ++ EQ E+  R++E+ REQE + QE   R+E++ REQ+ ++ EQE    R+E++  + E 
Sbjct: 382 KIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEE 441

Query: 736 ELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 778
            +Q++E+ LR  +E++Q E E+ +++EE+ +  E ++QE++EK
Sbjct: 442 MMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEK 484



 Score =  105 bits (261), Expect = 3e-22
 Identities = 70/259 (27%), Positives = 154/259 (59%), Gaps = 16/259 (6%)

Query: 539 RQRLENLRRKEEAEQLRRQKV--EEDKRRRLEEVKLKREERLRKVLQA-RERVEQM--KE 593
           +Q+ E + R+EE  Q + +K+  +E K R  EE   ++EE++ +  +  RE+ ++M  +E
Sbjct: 293 QQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQE 352

Query: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ 653
           EK ++ E+K  + +EK  + +EE++ E+  K +   ++M   E + +++EE R+ +  +Q
Sbjct: 353 EKIREQEEKIREQEEKMWR-QEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411

Query: 654 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE--QERREQE 711
           E++ R   E +++++EE   +  K  E + + + +E++ RE E + QE  E  QE+ E+ 
Sbjct: 412 EKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI 471

Query: 712 RREQERQLAEQERRREQERL--------QAERELQEREKALRLQKEQLQRELEEKKKKEE 763
           +R++E+   ++E+   QE+L        + E ++  +E+ +  Q+E++Q + E+ +++EE
Sbjct: 472 QRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEE 531

Query: 764 QQRLAERQLQEEQEKKAKE 782
           + R  E +L +++EK  ++
Sbjct: 532 KMREQEVRLWQQEEKMQEQ 550



 Score =  103 bits (256), Expect = 1e-21
 Identities = 70/252 (27%), Positives = 151/252 (59%), Gaps = 12/252 (4%)

Query: 538 ERQRLENLRRKEEAEQLRRQ--KVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
           E   L NL  +++ E++ RQ  K++E + +  E+ +LK  E+  K+ +  E++ + +EEK
Sbjct: 283 EENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQ-ELKIREQEEKMWRQEEKMHE-QEEK 340

Query: 596 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA--RRLRWLQQ 653
            ++ E K  + +EK  + +EE++ E++ K     +K+ E + + +++EE   R+   +++
Sbjct: 341 IREQEDKMWRQEEKIRE-QEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399

Query: 654 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR-EQER 712
           +EE+R+ +   Q+KK  EQ+   K  E +    ++E++ RE E   Q++ E+ R  E++ 
Sbjct: 400 QEEKRQEKMWRQEKKMREQD--EKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKM 457

Query: 713 REQERQLAEQERR--REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAER 770
           +E+E ++ EQE +  R++E++Q + E   R++ L  Q+E++  + E+  ++EE+    E 
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEE 517

Query: 771 QLQEEQEKKAKE 782
           ++QE++EK  ++
Sbjct: 518 KMQEQEEKMQRQ 529



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 74/290 (25%), Positives = 154/290 (53%), Gaps = 21/290 (7%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEE--DKRRRLEEVKLKREERLRKVLQARERVEQMKE 593
           EK R++ E +R +EE    + +K+ E  +K +  EE   ++EE++R+  + R+     +E
Sbjct: 353 EKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQE 412

Query: 594 EKKKQIEQKFAQIDEKT----EKAKE--ERLAEEKAKKKAAAKKMEEVEARRKQEEEA-- 645
           +K ++ ++K  + +E+     EK +E  E + +++ K +   +KM+E E + +++EE   
Sbjct: 413 KKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQ 472

Query: 646 RRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ 705
           R+   +Q++EE+   QE L K++E+  E      + +++  Q E+   ++E+ +++  + 
Sbjct: 473 RQEEKIQEQEEKTWRQEKLLKQEEKIWE------QEEKMWRQEEKMWEQEEKMQEQEEKM 526

Query: 706 ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 765
           +R+E++ REQE +L +QE + +++ ++ + EL+ER   L  QK +L   L    ++   Q
Sbjct: 527 QRQEEKMREQEVRLWQQEEKMQEQEVRLQ-ELEERLGKLG-QKAEL---LGGAGRESGSQ 581

Query: 766 RLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPP 815
           RL       + E K++EA    +  +           +YQ    G  A P
Sbjct: 582 RLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYVAAYQQLASGKEALP 631



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 67/323 (20%), Positives = 142/323 (43%), Gaps = 23/323 (7%)

Query: 338 RLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNG 397
           RL K+     A     +  + L  LLN +  +K+  ++++  E+ E +   E ++ E   
Sbjct: 266 RLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQE- 324

Query: 398 NNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRK----RSY 453
              W   +          +      E     Q+E   +Q +  RE  +   R+    R  
Sbjct: 325 EKMWRQEE-----KMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQ 379

Query: 454 KQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPR 513
            + + E +EE   ++E+++    K         K +R     +   ++ + +       R
Sbjct: 380 DEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIR--EQEEEMWRQEEKIR 437

Query: 514 SVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLK 573
            + +    +   LR        EK ++  E ++ +EE  Q + +K++E + +   + KL 
Sbjct: 438 ELEEMMQDQEEKLR-----EVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLL 492

Query: 574 REERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKME 633
           ++E   K+ +  E++ + +EEK  + E+K  + +EK ++ +EE++ E++ +     +KM+
Sbjct: 493 KQEE--KIWEQEEKMWR-QEEKMWEQEEKMQEQEEKMQR-QEEKMREQEVRLWQQEEKMQ 548

Query: 634 EVEARRKQEEEARRLRWLQQEEE 656
           E E R ++ EE  RL  L Q+ E
Sbjct: 549 EQEVRLQELEE--RLGKLGQKAE 569



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 58/257 (22%), Positives = 111/257 (43%), Gaps = 21/257 (8%)

Query: 560 EEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEK----TEKAKE 615
           +ED        KL+++ ++R     + R + + +EK  Q+ +  A ++ +    T++  E
Sbjct: 27  DEDSDLDFHINKLEQQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTKRWDE 86

Query: 616 ERLAEEKAKKKAAAKKMEEVEARRKQE---EEARRLRWLQQEEEERRHQELLQKKKEEEQ 672
           +   EE    K   + ++ V      +   E+A      +  +E +   +  Q+K  E+ 
Sbjct: 87  DDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNEKN 146

Query: 673 ERLRKAAEAK----RLAEQREQERREQERREQ----ERREQERREQERREQERQLAEQER 724
              RK    K    RL E   Q+R E    E+    +   +     E+  +ER     E 
Sbjct: 147 YTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSLEL 206

Query: 725 RR----EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEE--QQRLAERQLQEEQEK 778
            R    ++E  +   ELQE+ + +  +K ++Q  +++ K+K E  Q  L ++QLQ E ++
Sbjct: 207 YRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADR 266

Query: 779 KAKEAAGASKALNVTVD 795
             KE    S  L   V+
Sbjct: 267 LGKELQSVSAKLQAQVE 283


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score =  110 bits (275), Expect = 6e-24
 Identities = 137/554 (24%), Positives = 232/554 (41%), Gaps = 125/554 (22%)

Query: 242 DPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFS------TPTG 295
           DP G+G   GR+ + L           S A P  P R    +P+ P + +       P G
Sbjct: 329 DP-GRGPTWGRAGASLARGPQPDRTHPSAAVPVCP-RSASASPLTPCSVTRSVHRCAPAG 386

Query: 296 SRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIIC 355
            R +    R  P A  SP+P     + S V K+E   +       ++  +E +A  R   
Sbjct: 387 ERGE----RRKPNAGGSPAPVRRRPEASPVQKKEKKDKE------RENEKEKSALAR--- 433

Query: 356 HSYLERLLNVEVPQKVGSEQK---EPPEEAEPVAAAEPEVPENNGNNSW---------PH 403
               ER L            +       E  P + A P  P    + SW         P 
Sbjct: 434 ----ERSLKKRQSLPASPRARLSASTASELSPKSKARPSSP----STSWHRPASPCPSPG 485

Query: 404 NDTEIANSTPNPKPAASSPETPSAGQQEAK-TDQADGPREPPQSARRKRSYKQAVSELDE 462
               +    P+P+   +SP+     ++EAK +  A GP +  QS RR  + K++ +    
Sbjct: 486 PGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPAS- 544

Query: 463 EQHLEDEELQPPRSKTPS-SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK 521
                     P  S  PS +P P  K   P  T       +  ++T   AP   +     
Sbjct: 545 ----------PAPSPAPSPTPAPPQKEQPPAET-----PTDAAVLTSPPAPAPPV----- 584

Query: 522 RNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKV 581
             TP +              +     +EEA +L  +K      RR               
Sbjct: 585 --TPSKP-------------MAGTTDREEATRLLAEK------RR--------------- 608

Query: 582 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ 641
            QARE+ E+ ++E++ Q E             +++R+ EE+  ++A A+   E EARR++
Sbjct: 609 -QAREQREREEQERRLQAE-------------RDKRMREEQLAREAEARAEREAEARRRE 654

Query: 642 EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 701
           E+EAR     +QEE+ER     LQK+KEE + R R+ AE +RL  ++  +++EQER+E+ 
Sbjct: 655 EQEAREKAQAEQEEQER-----LQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERR 709

Query: 702 RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKK- 760
           +R +E  ++ R+    +++E +++++ +   A     E  KA+  +   LQ+E  +K++ 
Sbjct: 710 KRLEEIMKRTRKS---EVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEP 766

Query: 761 --KEEQQRLAERQL 772
             +E Q  L  ++L
Sbjct: 767 IPQEPQWSLPSKEL 780



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 97/402 (24%), Positives = 160/402 (39%), Gaps = 54/402 (13%)

Query: 410 NSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
           N+  +P P    PE     ++E K  + +  +E    AR +   K+          L   
Sbjct: 395 NAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSAS 454

Query: 470 ---ELQPPRSKTPSSPC-----PASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK 521
              EL P     PSSP      PAS    P             L     +PR    S   
Sbjct: 455 TASELSPKSKARPSSPSTSWHRPASPCPSP--------GPGHTLPPKPPSPRGTTAS--- 503

Query: 522 RNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKV 581
                   PK             +RRKEEA++       EDK +       ++E      
Sbjct: 504 --------PK-----------GRVRRKEEAKESPSAAGPEDKSQSKRRASNEKES----A 540

Query: 582 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKA---KEERLAEEKAKKKAAAKKMEEVEAR 638
             A               +++    +  T+ A        A      K  A   +  EA 
Sbjct: 541 APASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEAT 600

Query: 639 RKQEEEARRLR-WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 697
           R   E+ R+ R   ++EE+ERR Q    K+  EEQ  L + AEA+   E   + R EQE 
Sbjct: 601 RLLAEKRRQAREQREREEQERRLQAERDKRMREEQ--LAREAEARAEREAEARRREEQEA 658

Query: 698 REQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 757
           RE+ + EQE +E+ ++++E   A      E++RL+ E+  Q++E+    ++++ ++ LEE
Sbjct: 659 REKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQ----ERQERRKRLEE 714

Query: 758 KKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSP 799
             K+  +  ++E   +++Q+ K   A G+S      V+ +SP
Sbjct: 715 IMKRTRKSEVSE--TKQKQDSKEANANGSSPEPVKAVEARSP 754



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 59/225 (26%), Positives = 94/225 (41%), Gaps = 42/225 (18%)

Query: 408 IANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLE 467
           +A + P P+P+     +P      A     D P + P + +   S KQ   E +      
Sbjct: 18  VARTPPEPRPSPEGDPSPPPPPMSALVP--DTPPDTPPAMKNATSSKQLPLEPESPSGQV 75

Query: 468 DEELQPPRSKTPSS------PCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK 521
                PP+ ++PSS      P P +   R  R       R     +PT+ P S       
Sbjct: 76  GPRPAPPQEESPSSEAKSRGPTPPAMGPRDARP-----PRRSSQPSPTAVPAS------- 123

Query: 522 RNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLR----------------RQKVEEDKRR 565
            + P + + K +    ER +L   RR+E A+ L                 R+K  +++RR
Sbjct: 124 DSPPTKQEVKKA---GERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRR 180

Query: 566 RLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKT 610
           RLEE +LK E+R R  L+ R+R  Q  E+ K++ E    +  +KT
Sbjct: 181 RLEEQRLKAEQR-RAALEERQR--QKLEKNKERYEAAIQRSVKKT 222



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 31/94 (32%), Positives = 56/94 (59%), Gaps = 8/94 (8%)

Query: 708 REQERREQERQLAEQERRREQERLQAERE---LQEREKALRLQKEQLQ---RELEEKKKK 761
           +++ ++  ER    +ERR E+ +  A ++   L++ EKA  L+++QLQ   R LEE++ K
Sbjct: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188

Query: 762 EEQQR--LAERQLQEEQEKKAKEAAGASKALNVT 793
            EQ+R  L ERQ Q+ ++ K +  A   +++  T
Sbjct: 189 AEQRRAALEERQRQKLEKNKERYEAAIQRSVKKT 222



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 29/94 (30%), Positives = 57/94 (60%), Gaps = 5/94 (5%)

Query: 672 QERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERL 731
           ++ ++KA E  +LA++R +ER +     ++    E+ E+ +  +E+QL E+ RR E++RL
Sbjct: 129 KQEVKKAGERHKLAKERREERAKY-LAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187

Query: 732 QAERE---LQEREK-ALRLQKEQLQRELEEKKKK 761
           +AE+    L+ER++  L   KE+ +  ++   KK
Sbjct: 188 KAEQRRAALEERQRQKLEKNKERYEAAIQRSVKK 221



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 34/127 (26%), Positives = 62/127 (48%), Gaps = 25/127 (19%)

Query: 600 EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 659
           +Q+  +  E+ + AKE R  EE+AK  AA K +                 WL++EE+ + 
Sbjct: 129 KQEVKKAGERHKLAKERR--EERAKYLAAKKAV-----------------WLEKEEKAKA 169

Query: 660 HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQL 719
            +E      ++ QER R+  E +  AEQR     E++R++ E+ ++      +R  ++  
Sbjct: 170 LRE------KQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTW 223

Query: 720 AEQERRR 726
           AE  ++R
Sbjct: 224 AEIRQQR 230



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 28/122 (22%), Positives = 57/122 (46%), Gaps = 1/122 (0%)

Query: 614 KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE-EQ 672
           ++ R     ++    A    +    +++ ++A     L +E  E R + L  KK    E+
Sbjct: 104 RDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEK 163

Query: 673 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 732
           E   KA   K+L E+R +   ++ + EQ R   E R++++ E+ ++  E   +R  ++  
Sbjct: 164 EEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTW 223

Query: 733 AE 734
           AE
Sbjct: 224 AE 225



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 13/115 (11%)

Query: 652 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 711
           +QE ++   +  L K++ EE+ +   A +A  L    E+E + +  RE++ +E+ RR +E
Sbjct: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWL----EKEEKAKALREKQLQERRRRLEE 184

Query: 712 RREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQR 766
           +R     L  ++RR   E    ER+ Q+ EK     +  +QR +++   +  QQR
Sbjct: 185 QR-----LKAEQRRAALE----ERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 29/116 (25%), Positives = 59/116 (50%), Gaps = 15/116 (12%)

Query: 575 EERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEE 634
           ++ ++K  +  +  ++ +EE+ K +  K A   EK EKAK              A + ++
Sbjct: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAK--------------ALREKQ 174

Query: 635 VEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQ 690
           ++ RR++ EE R     ++   E R ++ L+K KE  +  ++++ + K  AE R+Q
Sbjct: 175 LQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVK-KTWAEIRQQ 229



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 28/104 (26%), Positives = 53/104 (50%), Gaps = 3/104 (2%)

Query: 597 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 656
           KQ  +K  +  +  ++ +EER     AKK    +K E+ +A R+++ + RR R    EE+
Sbjct: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRR---LEEQ 185

Query: 657 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQ 700
             + ++     +E ++++L K  E    A QR  ++   E R+Q
Sbjct: 186 RLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 96/452 (21%), Positives = 143/452 (31%), Gaps = 99/452 (21%)

Query: 66  RKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVT 125
           R++   S VQ + +    R     K +S+    R L+ + S+                 +
Sbjct: 404 RRRPEASPVQKKEKKDKER--ENEKEKSALARERSLKKRQSLP---------------AS 446

Query: 126 RAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQ 185
             A  +A+    L+  S   P SP+    +P                             
Sbjct: 447 PRARLSASTASELSPKSKARPSSPSTSWHRP----------------------------- 477

Query: 186 LMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKG 245
                P P   SP P     P     P+    +   K + R  E    S   A P+D   
Sbjct: 478 ---ASPCP---SPGPGHTLPPKP---PSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQ 528

Query: 246 QGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRT-DSQSVR 304
                         A  +P P  SP  P  P +E+  A        TPT +    S    
Sbjct: 529 SKRRASNEKESAAPASPAPSPAPSPT-PAPPQKEQPPA-------ETPTDAAVLTSPPAP 580

Query: 305 HSPIAPSSP---------SPQVLAQKYSLVAKQ---ESVVRRASRRLAKKTAEEP---AA 349
             P+ PS P         + ++LA+K     +Q   E   RR      K+  EE     A
Sbjct: 581 APPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREA 640

Query: 350 SGRIICHSYLERLLNVEVPQKVGSEQKE------PPEEAEPVAAAEPEVPENNGNNSWPH 403
             R    +   R    E  +K  +EQ+E        EEAE  +  E E         +  
Sbjct: 641 EARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQ 700

Query: 404 NDTEIANSTPN----PKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRS---YKQA 456
            + E            K    S  + +  +Q++K   A+G    P  A   RS    K+A
Sbjct: 701 QEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEA 760

Query: 457 VSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
           V +       E+   Q P+   PS   PAS V
Sbjct: 761 VQK-------EEPIPQEPQWSLPSKELPASLV 785



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 28/114 (24%), Positives = 52/114 (45%), Gaps = 10/114 (8%)

Query: 38  QEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSR--RKSRSSQ 95
           QEE ER+  ++  +E E   +  +++ R ++ +    Q++ R   R+RL    +++R S+
Sbjct: 666 QEEQERL--QKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSE 723

Query: 96  LSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATMALAAPSSPTPESP 149
           +S  + + +DS E  A     NGS    V    A +            P P+ P
Sbjct: 724 VSETK-QKQDSKEANA-----NGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEP 771



 Score = 31.6 bits (70), Expect = 3.5
 Identities = 42/162 (25%), Positives = 58/162 (35%), Gaps = 34/162 (20%)

Query: 189 TEPLPRTLSPT--PASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQ 246
           T P PR  SP   P+    P S  +P +  ++ P    A   + + +      P+ P GQ
Sbjct: 21  TPPEPRP-SPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLE-----PESPSGQ 74

Query: 247 GVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHS 306
                             GPR +P   +SP  E       P     P     D++  R S
Sbjct: 75  -----------------VGPRPAPPQEESPSSEAKSRGPTP-----PAMGPRDARPPRRS 112

Query: 307 PIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPA 348
               S PSP  +    S   KQE        +LAK+  EE A
Sbjct: 113 ----SQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERA 150


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score =  103 bits (257), Expect = 7e-22
 Identities = 89/287 (31%), Positives = 150/287 (52%), Gaps = 27/287 (9%)

Query: 510 SAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEE 569
           S P   M++    N     + K S   +ER  +E      ++ Q    +  E+ ++  +E
Sbjct: 131 SLPSRRMQNDTAENETTEKEEK-SESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKE 189

Query: 570 VKLKREERLRKVLQARERVEQMKEEKKKQIEQ-------KFAQIDEKTEKAKEERLAEEK 622
            + + EE+ ++      +VE M EEK  + ++       K  QI  +  K +EER  E+ 
Sbjct: 190 KEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEER--EQG 247

Query: 623 AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAK 682
           + + +  +KMEE +  R + E AR    L+ EE ER   E   + K+   ER R  AE K
Sbjct: 248 SDEISHHEKMEEEDKERAEAERAR----LEAEERERIKAE---QDKKIADERARIEAEEK 300

Query: 683 RLAEQREQ-ERREQER-REQERREQERREQERREQERQLAEQERRREQERLQAE--RELQ 738
             A++RE+ E  E+ER RE+E+R  E R++ + E++R   E++R +E+E+  AE  + ++
Sbjct: 301 AAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK 360

Query: 739 EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEE----QEKKAK 781
           E EK    ++++ + E EEK K EEQ+R   +QL+E+    QE K K
Sbjct: 361 EEEKRAAEERQRARAEEEEKAKVEEQKR--NKQLEEKKHAMQETKIK 405



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 97/403 (24%), Positives = 191/403 (47%), Gaps = 45/403 (11%)

Query: 410 NSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDE-EQHLED 468
           NS P+ +   ++  T   G  EA   +    RE     RR++  ++A+    E +  + D
Sbjct: 72  NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE----RRQKRLQEALERQKEFDPTITD 127

Query: 469 EELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRM 528
             L  P S+   +    ++            +R ++  T T     V KS+ K +     
Sbjct: 128 ASLSLP-SRRMQNDTAENETTEKEEKSESRQERYEIEETET-----VTKSYQKNDWRDAE 181

Query: 529 DPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKL-------------KRE 575
           + K    EKE +  E  +R    E      VEE      EE  +             K+E
Sbjct: 182 ENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQE 241

Query: 576 ERLRKVLQARERVEQMKEEKKKQIEQKFAQID----EKTEKAKEERLAEEKAKKKAAAKK 631
           E   +        E+M+EE K++ E + A+++    E+ +  +++++A+E+A+ +A  K 
Sbjct: 242 EEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKA 301

Query: 632 MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE 691
             + E  R++ EE  R+R     EEE+R  E  Q+ KEEE+   R A E +R+ E+ ++ 
Sbjct: 302 AAQ-ERERREAEERERMR-----EEEKRAAEERQRIKEEEK---RAAEERQRIKEEEKRA 352

Query: 692 RREQER-REQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQ 750
             E++R +E+E+R  E R++ R E+E +   +E++R ++  + +  +QE     +++ E+
Sbjct: 353 AEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQE----TKIKGEK 408

Query: 751 LQRELEEK---KKKEEQQRLAERQLQEEQEKKAKEAAGASKAL 790
           +++++E K   +KK ++ +L    L+++ E+K  +     + L
Sbjct: 409 VEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKL 451



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 111/443 (25%), Positives = 202/443 (45%), Gaps = 81/443 (18%)

Query: 357 SYLERLLNVEVP-QKVGSEQKEPPEEAEP-VAAAEPEVPENNGNNSWPHNDTEIANSTPN 414
           ++LERL   E   QK   E  E  +E +P +  A   +P     N    N+T     T  
Sbjct: 95  AFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENET-----TEK 149

Query: 415 PKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPP 474
            + + S  E     + E  T            + +K  ++ A     E++  E+EE + P
Sbjct: 150 EEKSESRQERYEIEETETVT-----------KSYQKNDWRDAEENKKEDKEKEEEEEEKP 198

Query: 475 RSKTPSSPCPASKVVRPLRTFLHTVQRNQM-LMTPTSAPRSVMKSFIKRNTPLRMDPKCS 533
           +  +                    +  NQ+ +M       S  ++ +       M  K  
Sbjct: 199 KRGS--------------------IGENQVEVMVEEKTTESQEETVV-------MSLKNG 231

Query: 534 FVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKE 593
            +  E  + E  R +   E    +K+EE+ + R E       ER R  L+A ER E++K 
Sbjct: 232 QISSEEPKQEEEREQGSDEISHHEKMEEEDKERAE------AERAR--LEAEER-ERIKA 282

Query: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ 653
           E+ K+I  + A+I+     A+E+  A+E+ +++A     EE E  R++E+ A   R   +
Sbjct: 283 EQDKKIADERARIE-----AEEKAAAQERERREA-----EERERMREEEKRAAEERQRIK 332

Query: 654 EEEERRHQELLQKKKEEE---QERLRKAAEAKRLAEQREQERREQERREQERREQERREQ 710
           EEE+R  +E  + K+EE+   +ER R   E KR AE+R++ R E+E  E+ + E+++R +
Sbjct: 333 EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEE--EKAKVEEQKRNK 390

Query: 711 ERREQERQLAEQERRREQERLQAERELQEREKAL--RLQKEQLQRELEEK---------K 759
           +  E++  + E + + E+   + E +    +KA   +LQ   L+++ EEK         K
Sbjct: 391 QLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREK 450

Query: 760 KKEEQQRLAERQLQEEQEKKAKE 782
            +E++    + ++++E+ KK KE
Sbjct: 451 LQEDKPTFKKEEIKDEKIKKDKE 473



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 68/237 (28%), Positives = 129/237 (54%), Gaps = 11/237 (4%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
           E++++R E  R + EAE+  R K E+DK+   E  +++ EE+     Q RER E  + E+
Sbjct: 259 EEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKA--AAQERERREAEERER 316

Query: 596 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 655
            ++ E+K A  + +  K +E+R AEE+ + K   K+  E   R K+EE+         EE
Sbjct: 317 MRE-EEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR------AAEE 369

Query: 656 EERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQ 715
            +R   E  +K K EEQ+R ++  E K   ++ + +  + E++ + +   E++ QE + Q
Sbjct: 370 RQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQ 429

Query: 716 ERQLAEQERRREQERLQAERE-LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ 771
              L +Q   +   ++QA+RE LQE +   + ++ + ++  ++K+ KEE +   +R+
Sbjct: 430 TAVLKKQGEEK-GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRK 485



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 112/523 (21%), Positives = 209/523 (39%), Gaps = 114/523 (21%)

Query: 336 SRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAA----EPE 391
           SRR+   TAE           S  ER    E      S QK    +AE         E E
Sbjct: 134 SRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEE 193

Query: 392 VPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKR 451
             E     S   N  E+       K   S  ET     +  +        EP Q   R+ 
Sbjct: 194 EEEKPKRGSIGENQVEVM---VEEKTTESQEETVVMSLKNGQISS----EEPKQEEERE- 245

Query: 452 SYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSA 511
              Q   E+   + +E+E+ +   ++               R  L   +R ++       
Sbjct: 246 ---QGSDEISHHEKMEEEDKERAEAE---------------RARLEAEERERIKAEQD-- 285

Query: 512 PRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQL---RRQKVEEDKRRRLE 568
                K        +  + K +  E+ER+  E   R  E E+     RQ+++E+++R  E
Sbjct: 286 -----KKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAE 340

Query: 569 EVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAA 628
           E +  +EE  R    A E  +++KEE+K+  E++     E+ EKAK E   E+K  K+  
Sbjct: 341 ERQRIKEEEKR----AAEERQRIKEEEKRAAEERQRARAEEEEKAKVE---EQKRNKQLE 393

Query: 629 AKK--MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAE 686
            KK  M+E + + ++ E+    +W+ +++ +    +    KK+ E++  +  A+ ++L E
Sbjct: 394 EKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQE 453

Query: 687 QREQERREQERREQERREQERREQERREQERQ---------------------------- 718
            +   ++E+ + E+ ++++E +E+ +   +R+                            
Sbjct: 454 DKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRP 513

Query: 719 ----------------------LAEQERRREQERLQAERELQEREKALRLQKEQLQRELE 756
                                 L E  RRR +   +   +L+++++   L+ E+L+++ E
Sbjct: 514 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 573

Query: 757 EKKK---KEEQQRLAE------------RQLQEEQEKKAKEAA 784
           E++K   +EEQ+R  E            R+L+EE E++  EAA
Sbjct: 574 ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 616



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 74/291 (25%), Positives = 127/291 (43%), Gaps = 51/291 (17%)

Query: 537 KERQRLENLRRKEEAEQLRR------------------------QKVEEDKRRRLEEVKL 572
           + R R E LR+K+E E L +                         +VE D      E   
Sbjct: 42  RRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLA 101

Query: 573 KREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKM 632
           +REER +K LQ  E +E+ KE      +   +    + +    E    EK +K  + ++ 
Sbjct: 102 RREERRQKRLQ--EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQER 159

Query: 633 EEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER 692
            E+E      +  ++  W   EE ++  +E    K+EEE+E+ ++ +  +   E   +E+
Sbjct: 160 YEIEETETVTKSYQKNDWRDAEENKKEDKE----KEEEEEEKPKRGSIGENQVEVMVEEK 215

Query: 693 REQERRE-------------QERREQERREQ---ERREQERQLAEQERRREQERLQAERE 736
             + + E             +E +++E REQ   E    E+   E + R E ER + E E
Sbjct: 216 TTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAE 275

Query: 737 LQEREKA---LRLQKEQLQRELEEKKKKEEQQR--LAERQLQEEQEKKAKE 782
            +ER KA    ++  E+ + E EEK   +E++R    ER+   E+EK+A E
Sbjct: 276 ERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAE 326



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 92/382 (24%), Positives = 169/382 (44%), Gaps = 33/382 (8%)

Query: 370 KVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPN----PKPAASSPETP 425
           ++   +K   E+ E   A    +            D +IA+         K AA   E  
Sbjct: 250 EISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERR 309

Query: 426 SAGQQEAKTDQADGPREPPQSARRKRSYKQAVSE---LDEEQHLEDEELQ--PPRSKTPS 480
            A ++E   ++     E  Q  R K   K+A  E   + EE+    EE Q      K  +
Sbjct: 310 EAEERERMREEEKRAAEERQ--RIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA 367

Query: 481 SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK-RNTPLRMDPKCSFVEKER 539
                ++     +  +   +RN+ L     A   + ++ IK      +++ K    +K +
Sbjct: 368 EERQRARAEEEEKAKVEEQKRNKQLEEKKHA---MQETKIKGEKVEQKIEGKWVNEKKAQ 424

Query: 540 Q-RLENLRRKEEAE------QLRRQKVEEDKRR-RLEEVKLKREERLRKVLQARERVEQM 591
           + +L+    K++ E      Q +R+K++EDK   + EE+K   +E+++K  + +E V+  
Sbjct: 425 EDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIK---DEKIKKDKEPKEEVKSF 481

Query: 592 KEEKKKQIEQKFAQIDEKTEKAK--EERLAEEKAKKKAAAKKME---EVEARRKQEEEAR 646
            + KK   E K    +  T K K  E   +    +     K+ E   +VEA ++ EE  R
Sbjct: 482 MDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRR 541

Query: 647 RLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQE 706
           R    + EE E+  Q+  Q++   E E L+K  E +R   + E++RR+QE  +++ RE+E
Sbjct: 542 RRGETESEEFEKLKQK--QQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEE 599

Query: 707 RREQERREQERQLAEQERRREQ 728
            + + + E ER+ AE   +R++
Sbjct: 600 EKRRLKEEIERRRAEAAEKRQK 621



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 80/338 (23%), Positives = 159/338 (47%), Gaps = 97/338 (28%)

Query: 536 EKERQRLENLRRKEEAEQLRRQKVEED-------KRRRLEEVKLKREERLRKVLQARERV 588
           E  RQ+ E +R   EAE++  Q+ ++D       +RRR  + +L++++    + Q  ++V
Sbjct: 9   ELRRQKREEMRL--EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 66

Query: 589 E-----QMKEEKKK------QIE--------QKFAQIDEKTEKAKEERLAEEK------- 622
           E      + +E+ K      Q+E        ++ A+ +E+ +K  +E L  +K       
Sbjct: 67  EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT 126

Query: 623 -AKKKAAAKKME----EVEARRKQEE-EARRLR-----------------WLQQEEEERR 659
            A     +++M+    E E   K+E+ E+R+ R                 W   EE ++ 
Sbjct: 127 DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE 186

Query: 660 HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE-------------QERREQE 706
            +E    K+EEE+E+ ++ +  +   E   +E+  + + E             +E +++E
Sbjct: 187 DKE----KEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEE 242

Query: 707 RREQ---------ERREQERQLAEQERRR----EQERLQAERE---------LQEREKAL 744
            REQ         +  E++++ AE ER R    E+ER++AE++         ++  EKA 
Sbjct: 243 EREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAA 302

Query: 745 RLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
             ++E+ + E  E+ ++EE++   ERQ  +E+EK+A E
Sbjct: 303 AQERERREAEERERMREEEKRAAEERQRIKEEEKRAAE 340



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 72/278 (25%), Positives = 122/278 (43%), Gaps = 49/278 (17%)

Query: 549 EEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK--KKQIEQKFAQI 606
           E   +LRRQK EE  R   E +  +R +   +   ARER  + ++E+  +KQ E+   Q+
Sbjct: 5   ERRRELRRQKREE-MRLEAERIAYQRNDDDEEEA-ARERRRRARQERLRQKQEEESLGQV 62

Query: 607 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 666
            ++ E   +  + +E+AK      ++E        ++EA  L  L + EE R  Q+ LQ+
Sbjct: 63  TDQVEVNAQNSVPDEEAKTTTTNTQVEG-------DDEAAFLERLARREERR--QKRLQE 113

Query: 667 KKEEEQE---------------RLRKAAEAKRLAEQREQERREQERREQER--------- 702
             E ++E               R++         E+ E+    QER E E          
Sbjct: 114 ALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQ 173

Query: 703 ----REQERREQERREQERQLAEQERRREQERLQAE-------RELQEREKALRLQKEQL 751
               R+ E  ++E +E+E +  E+ +R      Q E        E QE    + L+  Q+
Sbjct: 174 KNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQI 233

Query: 752 QRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKA 789
             E E K+++E +Q   E    E+ E++ KE A A +A
Sbjct: 234 SSE-EPKQEEEREQGSDEISHHEKMEEEDKERAEAERA 270



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 38/152 (25%), Positives = 76/152 (50%), Gaps = 16/152 (10%)

Query: 655 EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERRE 714
           ++  R +EL ++K+EE +       EA+R+A QR  +  E+  RE+ RR ++ R ++++E
Sbjct: 2   DDFERRRELRRQKREEMR------LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQE 55

Query: 715 QERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 774
           +E       +  +Q  + A+  + + E        Q++ + E        +RLA R  +E
Sbjct: 56  EE----SLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE----AAFLERLARR--EE 105

Query: 775 EQEKKAKEAAGASKALNVTVDVQSPACTSYQM 806
            ++K+ +EA    K  + T+   S +  S +M
Sbjct: 106 RRQKRLQEALERQKEFDPTITDASLSLPSRRM 137



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 93/404 (23%), Positives = 149/404 (36%), Gaps = 73/404 (18%)

Query: 328 QESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAA 387
           +E   R A  R   K  E+ AA  R       +R    E  Q++  E+K   EE +   A
Sbjct: 318 REEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA--AEERQRIKEEEKRAAEERQRARA 375

Query: 388 AEPE---VPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPP 444
            E E   V E   N         +  +    +      E     +++A+ D+        
Sbjct: 376 EEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKK 435

Query: 445 QSARRKRSYKQAVSELDEEQH-LEDEELQPPRSKTPSSPCPASKVVRPLRT-FLHTVQRN 502
           Q   +    +    +L E++   + EE++  + K    P    K     +  F     +N
Sbjct: 436 QGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN 495

Query: 503 QMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQ---------RLENLRRK----- 548
              MT         K     NT  R   + S   KE +         RLE LRR+     
Sbjct: 496 GEFMTH--------KLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETE 547

Query: 549 -EEAEQLR-------------------RQKV--EEDKRRRLEEV--KLKREERLRKVLQA 584
            EE E+L+                   R+KV  EE++RR+ EE   KL+ EE  R++   
Sbjct: 548 SEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRL--- 604

Query: 585 RERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE 644
                      K++IE++ A+  EK +K  E+ L+++K   K    K   +    K EE 
Sbjct: 605 -----------KEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSL----KIEER 649

Query: 645 ARRLRWLQQEEE--ERRHQELLQKKKEEEQERLRKAAEAKRLAE 686
           A  L    Q+    +  HQ  +  K +   E+   A E  + A+
Sbjct: 650 AEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAK 693


>gi|134152708 arginine and glutamate rich 1 [Homo sapiens]
          Length = 273

 Score =  100 bits (250), Expect = 5e-21
 Identities = 81/266 (30%), Positives = 140/266 (52%), Gaps = 27/266 (10%)

Query: 531 KCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQ 590
           K S   K+R R  +  R +E  + +R K  E KR R  E +  R       +  RER  +
Sbjct: 16  KSSKHNKKRSRSRSRSRDKERVR-KRSKSRESKRNRRRESR-SRSRSTNTAVSRRERDRE 73

Query: 591 MKEEKKKQIE------QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE 644
                  +I+       K + +DEK ++ +EE+ AE + ++K    + +E+E +  +EE 
Sbjct: 74  RASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKI---RQQEIEEKLIEEET 130

Query: 645 ARRLRWLQQEEEERRHQELLQKKKEE-EQERLRKAAEAKRLAEQREQERREQERREQERR 703
           ARR+    +E   +R +E L+K+K+E E+E LR+  EAKR+ E++  E  E++R+ +   
Sbjct: 131 ARRV----EELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAA 186

Query: 704 EQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEE 763
           ++ R E+ER ++E          E ER+  E   +  E   +L +EQL+   E++K  EE
Sbjct: 187 QKAREEEERAKRE----------ELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEE 236

Query: 764 QQRL-AERQLQEEQEKKAKEAAGASK 788
           + +L  ERQ Q+++E+K     G S+
Sbjct: 237 RMKLEQERQRQQKEEQKIILGKGKSR 262



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 49/190 (25%), Positives = 99/190 (52%), Gaps = 20/190 (10%)

Query: 609 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK 668
           +++  K  +  +++++ ++ ++  E V  R K  E  R  R  ++     R       ++
Sbjct: 11  RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRR--RESRSRSRSTNTAVSRR 68

Query: 669 EEEQERLRKAAE---------AKRLAEQREQERREQERREQERREQERREQERREQERQL 719
           E ++ER     +         +KR +   +Q+R E+E++ +  R+++ R+QE  E+   L
Sbjct: 69  ERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEK---L 125

Query: 720 AEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKK 779
            E+E  R  E L A+R  +E EK    +K++++RE+   ++ EE +R+ E+QL EE E++
Sbjct: 126 IEEETARRVEELVAKRVEEELEK----RKDEIEREV--LRRVEEAKRIMEKQLLEELERQ 179

Query: 780 AKEAAGASKA 789
            +    A KA
Sbjct: 180 RQAELAAQKA 189



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 51/185 (27%), Positives = 95/185 (51%), Gaps = 17/185 (9%)

Query: 528 MDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKR-EERLRKVLQARE 586
           +D K    E+E++     +RK   +++  + +EE+  RR+EE+  KR EE L K     E
Sbjct: 95  LDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIE 154

Query: 587 RVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEAR 646
           R    + E+ K+I +K  Q+ E+ E+ ++  LA +KA+++    K EE+E  R  EE  R
Sbjct: 155 REVLRRVEEAKRIMEK--QLLEELERQRQAELAAQKAREEEERAKREELE--RILEENNR 210

Query: 647 RLRWLQQ----------EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQE 696
           ++   Q           EE+ + H+E +  K E+E++R +K  +   L + + + +    
Sbjct: 211 KIAEAQAKLAEEQLRIVEEQRKIHEERM--KLEQERQRQQKEEQKIILGKGKSRPKLSFS 268

Query: 697 RREQE 701
            + Q+
Sbjct: 269 LKTQD 273



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 49/179 (27%), Positives = 87/179 (48%), Gaps = 17/179 (9%)

Query: 458 SELDEEQHLEDEELQPP--RSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTP-TSAPRS 514
           S LDE+Q  E+EE +    R +         K++        T +R + L+         
Sbjct: 93  SSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEE-----ETARRVEELVAKRVEEELE 147

Query: 515 VMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKR 574
             K  I+R    R++     +EK  Q LE L R+ +AE   ++  EE++R + EE++   
Sbjct: 148 KRKDEIEREVLRRVEEAKRIMEK--QLLEELERQRQAELAAQKAREEEERAKREELERIL 205

Query: 575 EERLRKVLQARER--VEQMK--EEKKKQIEQKFAQIDEKTEKAKEER---LAEEKAKKK 626
           EE  RK+ +A+ +   EQ++  EE++K  E++     E+  + KEE+   L + K++ K
Sbjct: 206 EENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPK 264


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  100 bits (249), Expect = 6e-21
 Identities = 79/271 (29%), Positives = 139/271 (51%), Gaps = 25/271 (9%)

Query: 538  ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERL--------RKVLQARERVE 589
            E    +  + +EEAE+LRRQ  +E +R+R  EV+L    +         ++ LQA E + 
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1542

Query: 590  QMKEEKKKQIEQ----KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA 645
               EE ++++ Q    +  Q+    E A+    AE ++K+ + A+K  ++E  R  +EE 
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE--RSLQEEH 1600

Query: 646  RRLRWLQQEEEERRHQELLQKKKEEEQER-----LRKAAEAKRL---AEQREQERREQER 697
              +  L++E E R  Q+   ++  EE ER       KA EA RL   AE+  Q++   + 
Sbjct: 1601 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1660

Query: 698  REQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 757
              ++++E+  RE  RR +  + A ++R   ++ L+ +R+L E     RL  EQ    L  
Sbjct: 1661 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1720

Query: 758  KKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788
            + ++ EQQR   + L+EE  +  +EAA A++
Sbjct: 1721 ETEQGEQQR---QLLEEELARLQREAAAATQ 1748



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 89/313 (28%), Positives = 153/313 (48%), Gaps = 50/313 (15%)

Query: 524  TPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQ 583
            T L+ + + +  EKE +  E LRR  E E  +R+++EE   +   +++ +R  +LRK   
Sbjct: 1846 TRLKTEAEIALKEKEAEN-ERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASD 1903

Query: 584  AR-ERVEQMKEE---KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARR 639
            +  ER + + E+   +++Q+E++   +    EKA   +   E    +  +   + + ++ 
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963

Query: 640  KQEEEARRLRWLQQEEEERRHQ--ELLQKK--KEEEQERLRKAA------------EAKR 683
            + E EA R R L  EEE RR +  E +QK    EEE  R RKAA            EA+R
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023

Query: 684  LAEQREQERREQ-----------------------ERREQERREQERREQERREQERQLA 720
            L E+ EQE   Q                       +++EQE ++  ++EQ   +Q R  A
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083

Query: 721  EQERR----REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 776
            E  RR     E+ R+QAERE  +  + +  + E+L++  EE+ +   Q + A  +L++E 
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142

Query: 777  EKKAKEAAGASKA 789
            E++A   A A +A
Sbjct: 2143 EQEAARRAQAEQA 2155



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 105/408 (25%), Positives = 178/408 (43%), Gaps = 70/408 (17%)

Query: 430  QEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK---TPSSPCPAS 486
            Q+    QA+  ++  ++ R  R   +A  +   ++ L ++EL+  R     T      A 
Sbjct: 1653 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1712

Query: 487  KVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLR 546
            + +  LR      ++ + L+    A               R+  + +   ++RQ LE   
Sbjct: 1713 QELIRLRAETEQGEQQRQLLEEELA---------------RLQREAAAATQKRQELEAEL 1757

Query: 547  RKEEAEQ----LRRQKVEEDKRRRLEEVKLKREE---RLRKVLQARERVEQMKEEKKKQI 599
             K  AE       + + EE+ R   E+ K + E    R R++ +   R+  + EE K+Q 
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ- 1816

Query: 600  EQKFAQIDEKTEKAKEERLAEEK--AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE-- 655
             ++ A+ D   ++A+ ER+  EK  A  +A   K E   A +++E E  RLR L ++E  
Sbjct: 1817 -RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875

Query: 656  EERRHQELLQKKKEEEQERL---RKAAEA-----KRLAEQREQERREQERR--------- 698
            + RR +E   + K + +ERL   RKA+++     K L E   ++RR+ E           
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935

Query: 699  --------------------EQERREQERREQERREQERQLAEQERRREQERLQAERELQ 738
                                E   R +E+ E E   Q +  AE+ERRR +   + ++ L 
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995

Query: 739  EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE--EQEKKAKEAA 784
              E+A R +K  L+     K K EE +RL ER  QE   Q + A+EAA
Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 102/372 (27%), Positives = 174/372 (46%), Gaps = 35/372 (9%)

Query: 429  QQEAKTDQADGPREPPQSARR-KRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASK 487
            Q++A  ++ +   E  +  +R  + Y  A+ + + +      +L+P      +SP    K
Sbjct: 1250 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-----ASPAKKPK 1304

Query: 488  VVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK--RNTPLRMDPKCSFVEKERQRLENL 545
            V     +    +Q    L T  S   ++   +IK    T  RM+        E +RL   
Sbjct: 1305 VQSGSES---VIQEYVDLRTHYSELTTLTSQYIKFISETLRRME--------EEERLAEQ 1353

Query: 546  RRKEEAEQLRRQKVEEDKRRRLEEVKLK---REERLRKVLQARERVEQM-KEEKKKQIEQ 601
            +R EE E+L   +   +K+R+L E   +   + ER  K LQ R + E + +EE     +Q
Sbjct: 1354 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1413

Query: 602  KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQ 661
            +   I E+ ++ ++   AE +AK    A++ E  E  R + EE  R+  LQ E  ER+  
Sbjct: 1414 QKRSIQEELQQLRQSSEAEIQAK----ARQAEAAERSRLRIEEEIRVVRLQLEATERQ-- 1467

Query: 662  ELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAE 721
               +   E E + LR  AE     +++ QE  E+ RR+ +   Q +R+ E     R  AE
Sbjct: 1468 ---RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524

Query: 722  QERRREQER-LQA--ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 778
             E  RE++R LQA  E  LQ  E   RL++ +++R  + +   E  QR AE +LQ ++  
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1584

Query: 779  KAKEAAGASKAL 790
             A++ A   ++L
Sbjct: 1585 FAEKTAQLERSL 1596



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 78/274 (28%), Positives = 137/274 (50%), Gaps = 26/274 (9%)

Query: 535  VEKERQRLE-----NLRRKEEAEQLRRQKVEEDKRRR-----LEEVKLKREERLRKVLQA 584
            +EK+RQ  E       + + EA++L+++  EE  RR       ++ K   +E L+++ Q+
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1428

Query: 585  RERVEQMKEEKKKQIEQKFAQIDEKTE------KAKEERLAEEKAKKKAAAKKMEEVEAR 638
             E   Q K  + +  E+   +I+E+        +A E +    + + +A   + EE EA+
Sbjct: 1429 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1488

Query: 639  RKQ-EEEARRLRWLQQEEEERRHQ---ELLQKKKEE-----EQERLRKAAEAKRLAEQRE 689
            ++Q +EEA RLR   Q+E +R+ Q   EL  + K E     E++R  +A E  RL  +  
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548

Query: 690  QERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKE 749
            + R  Q   E+ R+ Q   E  +R  E +L  +     ++  Q ER LQE   A+   +E
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608

Query: 750  QLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 783
            + +R  +++ + E  +  AER+L E  + KA EA
Sbjct: 1609 EAERRAQQQAEAERAREEAEREL-ERWQLKANEA 1641



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 88/336 (26%), Positives = 165/336 (49%), Gaps = 29/336 (8%)

Query: 526  LRMDPKCSFVEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRL---EEVKLKREERLRK 580
            +R + + +   KE+  LE  R+++ A  E+ RR++ EE  ++ L   EE   +R+  L +
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010

Query: 581  VLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRK 640
            V + + +VE+ +  +++  ++   Q+    E A++   AEEKA   A  +K +E++   +
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070

Query: 641  QEE--------EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER 692
            QE+        EA   R   +E EE R    +Q ++E  Q R R+  EA+RL +Q  +E+
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEAR----VQAEREAAQSR-RQVEEAERL-KQSAEEQ 2124

Query: 693  REQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER--EKALRLQKEQ 750
             +   + Q   E+ R+E E+    R  AEQ   R+++   AE E  ++  E+ LR QK Q
Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQ 2183

Query: 751  LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQG 810
            +++EL   + + E+    +  L EE ++   EA  A++  +    V+    +      + 
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS---QVEEELFSVRVQMEEL 2240

Query: 811  HRAPPKINPDNYGMDLNSDDST----DDEAHPRKPI 842
             +   +I  +N  + L   D+T     +EA   K +
Sbjct: 2241 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 120/513 (23%), Positives = 221/513 (43%), Gaps = 60/513 (11%)

Query: 299  DSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSY 358
            +SQ  R + +  +S   +V A+  +   KQ ++      RL  + AE      R +  + 
Sbjct: 1506 ESQRKRQAEVELAS---RVKAEAEAAREKQRALQALEELRLQAEEAE------RRLRQAE 1556

Query: 359  LERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
            +ER   V+V  +      E   +++  + AE          S       +A      +  
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR 1613

Query: 419  ASSPETPSAGQQEA---------KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
            A         ++EA         K ++A   R   +   +++S  QA +E  +E   E E
Sbjct: 1614 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---EAE 1670

Query: 470  ELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMD 529
                 R K         + VR        +++ + L   T+  R   +  +     +R+ 
Sbjct: 1671 REARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL-----IRLR 1719

Query: 530  PKCSFVEKERQRLEN----LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR 585
             +    E++RQ LE     L+R+  A   +RQ++E +    L +V+ + E  L    +A 
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----LAKVRAEMEVLLASKARAE 1775

Query: 586  ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE- 644
            E      E+ K+++E +  +  E  E+A   R   E+AK++   +  EE  AR++ E E 
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--QLAEEDAARQRAEAER 1833

Query: 645  --ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER 702
              A +L  + +    +   E+  K+KE E ERLR+ AE +    +R +E+  Q + + E 
Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1893

Query: 703  REQERREQERREQERQ--LAE---QERRREQERLQAERELQEREKA----LRLQKEQLQR 753
            R  + R+    E ERQ  L E   ++RR+ +E + A +   E+  A    L L+  +++ 
Sbjct: 1894 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1953

Query: 754  ELEEKKKKEEQQRL---AERQLQEEQEKKAKEA 783
              E+  + +EQ  L    +RQL  E+E++ +EA
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 83/295 (28%), Positives = 143/295 (48%), Gaps = 59/295 (20%)

Query: 540  QRLENLRRKEEAEQLRRQKVEED---KRRRLEEVKLKREERLRKVLQARERVE------- 589
            +RL  LR+  ++E  R++ + ED   +RR++EE  L  +    K    +  +E       
Sbjct: 1893 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952

Query: 590  -----QMKEEKKKQIE----QKFAQIDEKTEKAKEERLAEEKAKKKAAAKK----MEEVE 636
                  ++ +++ ++E    ++ A  +E+  +  EER+ +  A ++ AA++    +EEVE
Sbjct: 1953 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2012

Query: 637  ARRKQEEEARRLRWLQQEE------------------EERRHQELLQKKKEEEQ------ 672
              + + EEARRLR   ++E                  EE+ H   +Q+K++E Q      
Sbjct: 2013 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2072

Query: 673  ----ERLRKAAEAKRLAEQREQERREQERRE--QERR---EQERREQERREQERQLAEQE 723
                ++LR  AEA R A +  +E R Q  RE  Q RR   E ER +Q   EQ +  A+ +
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132

Query: 724  RRREQERLQAERELQER---EKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEE 775
               E+ R +AE+E   R   E+A   QK+    E+E+ KK  EQ    + Q+++E
Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 87/289 (30%), Positives = 146/289 (50%), Gaps = 49/289 (16%)

Query: 539  RQRLENLRRKEEAE---QLRRQKVEEDKRRRLEE------VKLKREERLR-------KVL 582
            ++ L+ LR+  EAE   + R+ +  E  R R+EE      ++L+  ER R       + L
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478

Query: 583  QAR-ERVEQMKEEKKKQIEQKFAQIDEKTEKAKE---ERLAEEKAKKKAAAKK---MEEV 635
            +AR E  E  K + +++ E+   Q+ +++++ ++   E  +  KA+ +AA +K   ++ +
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1538

Query: 636  EARRKQEEEARRLRWLQQEEEERRHQ-----ELLQKKKEEEQERLRKAAEAKRLAEQREQ 690
            E  R Q EEA R   L+Q E ER  Q     E  Q+  E E +  ++A+ A++ A+    
Sbjct: 1539 EELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQS-KRASFAEKTAQLERS 1595

Query: 691  ERREQERREQERREQERREQERREQERQLAEQERRREQE------------RLQAERELQ 738
             + E     Q R E ERR Q++ E ER  A +E  RE E            RLQAE   Q
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAER--AREEAERELERWQLKANEALRLRLQAEEVAQ 1653

Query: 739  EREKA---LRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 784
            ++  A      QKE+ +RE   + K EE Q + +R+L E++ +K ++ A
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLA 1701



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 126/557 (22%), Positives = 232/557 (41%), Gaps = 107/557 (19%)

Query: 316  QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
            Q L Q+ S++ +       A+RR A++  E    + R    S   R    E  +   S +
Sbjct: 2067 QTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQS---RRQVEEAERLKQSAE 2122

Query: 376  KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTD 435
            ++    A+  AAAE    E          + E A      + A    +   A  ++ K  
Sbjct: 2123 EQAQARAQAQAAAEKLRKEA---------EQEAARRAQAEQAALRQKQAADAEMEKHKKF 2173

Query: 436  QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV------- 488
                 R+  Q  +   + +  + E D +++L DEELQ  +++   +    S+V       
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233

Query: 489  ------VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRL 542
                  +  L+  +    R  +L    +  R + +   K         + S   +E  RL
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293

Query: 543  ENLRRKEEAEQ--LRRQKVEEDKRRRLEEVKLKREERLRKVLQ--ARERVEQMKEEKKKQ 598
              L  ++ A+Q  L  + ++E  +   E  +LK E  L +  +  A+E+  +++E+K++ 
Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353

Query: 599  IEQKFAQID--EKTEKAKEERLAEEKAKKKAAAKKMEEVE-ARRKQEEEARRLRWLQQEE 655
             +Q   +    ++T +A+ +R  E  A+ +    ++ E+  A+ + EE+A+R R   +E 
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413

Query: 656  EERRHQ---------------ELLQKKKEEEQERLRKA-AEAKRLAEQREQERR------ 693
             E+ H+               E+ +++ + + ERLR+A AE +R  E+ +QE +      
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2473

Query: 694  ------------------------------------EQERREQER-------REQERREQ 710
                                                EQE+ + E+       + Q+ RE+
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2533

Query: 711  ERREQERQLAEQERRR------EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 764
            ++R+Q++   EQER+R      E  R Q E E   R K   LQ+ + QR  +E+   EE 
Sbjct: 2534 QQRQQQQM--EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN 2591

Query: 765  QRLAER-QLQEEQEKKA 780
            QRL E+ QL EEQ + A
Sbjct: 2592 QRLREQLQLLEEQHRAA 2608



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 78/288 (27%), Positives = 146/288 (50%), Gaps = 32/288 (11%)

Query: 543  ENLRRKEEAEQLRRQKVEEDKRRRLE-EVKLKREERLRKV-LQARERVEQMKEEKKKQIE 600
            E LRR EE E+L  Q+  E++ R  E E  L+++ +L +   QA+ + E+  +E +++++
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398

Query: 601  QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 660
            ++  + +E    A++++ + ++  ++       E++A+ +Q E A R R L+ EEE R  
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIR-- 1455

Query: 661  QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720
               + + + E  ER R  AE     E +    R +E   Q+R+ QE  E+ RR    Q+ 
Sbjct: 1456 ---VVRLQLEATERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRR----QVQ 1504

Query: 721  EQERRREQ------ERLQAERE-LQEREKA------LRLQKEQLQREL---EEKKKKEEQ 764
            ++ +R+ Q       R++AE E  +E+++A      LRLQ E+ +R L   E ++ ++ Q
Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1564

Query: 765  QRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHR 812
              L   Q   E E ++K A+ A K   +   +Q       Q+  +  R
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER 1612



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 78/281 (27%), Positives = 133/281 (47%), Gaps = 27/281 (9%)

Query: 535  VEKERQ---RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQM 591
            VE+ RQ    LE  +R  EAE   ++    +K  +LE    +    + ++ +  ER  Q 
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 592  KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 651
            + E ++  E+   +++    KA E      +A++ A  K + + EA +++EE  R  R  
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676

Query: 652  QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE--QERREQERREQER------- 702
             + EE+   Q  L +++ E+Q +L +    +RLA ++E  + R E E+ EQ+R       
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736

Query: 703  ----REQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE- 757
                RE     Q+R+E E +LA+   R E E L A +   E E     +K + + E E  
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKV--RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794

Query: 758  --KKKKEEQQRL------AERQLQEEQEKKAKEAAGASKAL 790
              ++  EE  RL      A+RQ Q  +E  A++ A A + L
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1835



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 126/521 (24%), Positives = 216/521 (41%), Gaps = 80/521 (15%)

Query: 319  AQKYSLVAKQESVVRRASRRLAKK-TAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKE 377
            A++  L A++E   R A  R+ K   AEE AA  R      +ERL       KV  E + 
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL-----KAKV-EEARR 2023

Query: 378  PPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQA 437
              E AE  +A + ++ +          +   A +    +              +    +A
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083

Query: 438  DGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLH 497
            +  R   + A   R   +  +     Q  E E L+    +   +   A      LR    
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--- 2140

Query: 498  TVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQ---- 553
              +  Q       A ++ ++   K+     M+    F E      + LR+K + EQ    
Sbjct: 2141 --EAEQEAARRAQAEQAALRQ--KQAADAEMEKHKKFAE------QTLRQKAQVEQELTT 2190

Query: 554  LRRQKVEEDKRRRLEEVKLKR-EERLRKVLQARERVEQMKEEKKKQIEQKF---AQIDEK 609
            LR Q  E D ++ L + +L+R +    +  + R +VE+     + Q+E+     A+I+ +
Sbjct: 2191 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2250

Query: 610  T------EKAKEERLAEEKAKKKAAAKKMEEVEARRK-QEEEARRLRWLQQEEEERRH-- 660
                   +K   +R  +E+A+K    K++ E  AR     +EA RLR L +E+  ++   
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKM---KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307

Query: 661  -QELLQKKKEEEQERLRKAAEAKRLAEQR----EQERREQERREQERRE--------QER 707
             +++L++K +  QE  R  AEA+ L +Q+    EQ RR QE +EQ  ++        Q  
Sbjct: 2308 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2367

Query: 708  REQERREQERQLAEQER-------------RREQE----RLQAER--------ELQEREK 742
             E ER+ Q    AE ER             R E++    R QAE         EL  +EK
Sbjct: 2368 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427

Query: 743  ALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 783
               +Q  ++QR+  +   +  ++ +AE  L+ E+EK  +EA
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAE--LEREKEKLQQEA 2466



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 65/243 (26%), Positives = 118/243 (48%), Gaps = 32/243 (13%)

Query: 578  LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA 637
            + + L+  E  E++ E+++ +  ++ A+++   EK ++  LAE  A+ KA A++  +   
Sbjct: 1337 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ--LAEAHAQAKAQAEREAKELQ 1394

Query: 638  RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 697
            +R QEE  RR       EE     +  ++  +EE ++LR+++EA+  A+ R+ E  E+ R
Sbjct: 1395 QRMQEEVVRR-------EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447

Query: 698  REQE------RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQ---- 747
               E      R + E  E++R   E +L     R E+   Q +R+ QE  + LR Q    
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDE 1506

Query: 748  ---KEQLQRELEEKKKKEEQ---------QRLAERQLQEEQEKKAKEAAGASKALNVTVD 795
               K Q + EL  + K E +         Q L E +LQ E+ ++    A   +A  V V 
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566

Query: 796  VQS 798
            +++
Sbjct: 1567 LET 1569



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 63/289 (21%), Positives = 133/289 (46%), Gaps = 35/289 (12%)

Query: 534  FVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR---KVLQARERVEQ 590
            ++EK +     +R  + AE++ R   E+ K  +     L   E  +   K L+A+   +Q
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1143

Query: 591  MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA--------RRKQE 642
               +  +   +   ++ E+ ++   ER  E +  ++  A+ +E  +A        +R+ E
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1203

Query: 643  EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR--EQERREQ 700
            +  R+LR+ + E  +     L   ++ +EQ +    A+++ + EQ  QE+   E+  R  
Sbjct: 1204 QLGRQLRYYR-ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1262

Query: 701  ERREQERREQER-----REQERQLAEQERRRE-------QERLQ--AERELQE------- 739
            E+ E+ +R  ++     ++ E QL   + + E       + ++Q  +E  +QE       
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322

Query: 740  REKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788
              +   L  + ++   E  ++ EE++RLAE+Q  EE+E+ A+  A   K
Sbjct: 1323 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1371


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  100 bits (249), Expect = 6e-21
 Identities = 79/271 (29%), Positives = 139/271 (51%), Gaps = 25/271 (9%)

Query: 538  ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERL--------RKVLQARERVE 589
            E    +  + +EEAE+LRRQ  +E +R+R  EV+L    +         ++ LQA E + 
Sbjct: 1487 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1546

Query: 590  QMKEEKKKQIEQ----KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA 645
               EE ++++ Q    +  Q+    E A+    AE ++K+ + A+K  ++E  R  +EE 
Sbjct: 1547 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE--RSLQEEH 1604

Query: 646  RRLRWLQQEEEERRHQELLQKKKEEEQER-----LRKAAEAKRL---AEQREQERREQER 697
              +  L++E E R  Q+   ++  EE ER       KA EA RL   AE+  Q++   + 
Sbjct: 1605 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1664

Query: 698  REQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 757
              ++++E+  RE  RR +  + A ++R   ++ L+ +R+L E     RL  EQ    L  
Sbjct: 1665 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1724

Query: 758  KKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788
            + ++ EQQR   + L+EE  +  +EAA A++
Sbjct: 1725 ETEQGEQQR---QLLEEELARLQREAAAATQ 1752



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 89/313 (28%), Positives = 153/313 (48%), Gaps = 50/313 (15%)

Query: 524  TPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQ 583
            T L+ + + +  EKE +  E LRR  E E  +R+++EE   +   +++ +R  +LRK   
Sbjct: 1850 TRLKTEAEIALKEKEAEN-ERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASD 1907

Query: 584  AR-ERVEQMKEE---KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARR 639
            +  ER + + E+   +++Q+E++   +    EKA   +   E    +  +   + + ++ 
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1967

Query: 640  KQEEEARRLRWLQQEEEERRHQ--ELLQKK--KEEEQERLRKAA------------EAKR 683
            + E EA R R L  EEE RR +  E +QK    EEE  R RKAA            EA+R
Sbjct: 1968 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2027

Query: 684  LAEQREQERREQ-----------------------ERREQERREQERREQERREQERQLA 720
            L E+ EQE   Q                       +++EQE ++  ++EQ   +Q R  A
Sbjct: 2028 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087

Query: 721  EQERR----REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 776
            E  RR     E+ R+QAERE  +  + +  + E+L++  EE+ +   Q + A  +L++E 
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEA 2146

Query: 777  EKKAKEAAGASKA 789
            E++A   A A +A
Sbjct: 2147 EQEAARRAQAEQA 2159



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 105/408 (25%), Positives = 178/408 (43%), Gaps = 70/408 (17%)

Query: 430  QEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK---TPSSPCPAS 486
            Q+    QA+  ++  ++ R  R   +A  +   ++ L ++EL+  R     T      A 
Sbjct: 1657 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1716

Query: 487  KVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLR 546
            + +  LR      ++ + L+    A               R+  + +   ++RQ LE   
Sbjct: 1717 QELIRLRAETEQGEQQRQLLEEELA---------------RLQREAAAATQKRQELEAEL 1761

Query: 547  RKEEAEQ----LRRQKVEEDKRRRLEEVKLKREE---RLRKVLQARERVEQMKEEKKKQI 599
             K  AE       + + EE+ R   E+ K + E    R R++ +   R+  + EE K+Q 
Sbjct: 1762 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ- 1820

Query: 600  EQKFAQIDEKTEKAKEERLAEEK--AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE-- 655
             ++ A+ D   ++A+ ER+  EK  A  +A   K E   A +++E E  RLR L ++E  
Sbjct: 1821 -RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1879

Query: 656  EERRHQELLQKKKEEEQERL---RKAAEA-----KRLAEQREQERREQERR--------- 698
            + RR +E   + K + +ERL   RKA+++     K L E   ++RR+ E           
Sbjct: 1880 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1939

Query: 699  --------------------EQERREQERREQERREQERQLAEQERRREQERLQAERELQ 738
                                E   R +E+ E E   Q +  AE+ERRR +   + ++ L 
Sbjct: 1940 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1999

Query: 739  EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE--EQEKKAKEAA 784
              E+A R +K  L+     K K EE +RL ER  QE   Q + A+EAA
Sbjct: 2000 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2047



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 102/372 (27%), Positives = 174/372 (46%), Gaps = 35/372 (9%)

Query: 429  QQEAKTDQADGPREPPQSARR-KRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASK 487
            Q++A  ++ +   E  +  +R  + Y  A+ + + +      +L+P      +SP    K
Sbjct: 1254 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-----ASPAKKPK 1308

Query: 488  VVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK--RNTPLRMDPKCSFVEKERQRLENL 545
            V     +    +Q    L T  S   ++   +IK    T  RM+        E +RL   
Sbjct: 1309 VQSGSES---VIQEYVDLRTHYSELTTLTSQYIKFISETLRRME--------EEERLAEQ 1357

Query: 546  RRKEEAEQLRRQKVEEDKRRRLEEVKLK---REERLRKVLQARERVEQM-KEEKKKQIEQ 601
            +R EE E+L   +   +K+R+L E   +   + ER  K LQ R + E + +EE     +Q
Sbjct: 1358 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1417

Query: 602  KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQ 661
            +   I E+ ++ ++   AE +AK    A++ E  E  R + EE  R+  LQ E  ER+  
Sbjct: 1418 QKRSIQEELQQLRQSSEAEIQAK----ARQAEAAERSRLRIEEEIRVVRLQLEATERQ-- 1471

Query: 662  ELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAE 721
               +   E E + LR  AE     +++ QE  E+ RR+ +   Q +R+ E     R  AE
Sbjct: 1472 ---RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1528

Query: 722  QERRREQER-LQA--ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 778
             E  RE++R LQA  E  LQ  E   RL++ +++R  + +   E  QR AE +LQ ++  
Sbjct: 1529 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1588

Query: 779  KAKEAAGASKAL 790
             A++ A   ++L
Sbjct: 1589 FAEKTAQLERSL 1600



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 78/274 (28%), Positives = 137/274 (50%), Gaps = 26/274 (9%)

Query: 535  VEKERQRLE-----NLRRKEEAEQLRRQKVEEDKRRR-----LEEVKLKREERLRKVLQA 584
            +EK+RQ  E       + + EA++L+++  EE  RR       ++ K   +E L+++ Q+
Sbjct: 1373 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1432

Query: 585  RERVEQMKEEKKKQIEQKFAQIDEKTE------KAKEERLAEEKAKKKAAAKKMEEVEAR 638
             E   Q K  + +  E+   +I+E+        +A E +    + + +A   + EE EA+
Sbjct: 1433 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1492

Query: 639  RKQ-EEEARRLRWLQQEEEERRHQ---ELLQKKKEE-----EQERLRKAAEAKRLAEQRE 689
            ++Q +EEA RLR   Q+E +R+ Q   EL  + K E     E++R  +A E  RL  +  
Sbjct: 1493 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1552

Query: 690  QERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKE 749
            + R  Q   E+ R+ Q   E  +R  E +L  +     ++  Q ER LQE   A+   +E
Sbjct: 1553 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1612

Query: 750  QLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 783
            + +R  +++ + E  +  AER+L E  + KA EA
Sbjct: 1613 EAERRAQQQAEAERAREEAEREL-ERWQLKANEA 1645



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 88/336 (26%), Positives = 165/336 (49%), Gaps = 29/336 (8%)

Query: 526  LRMDPKCSFVEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRL---EEVKLKREERLRK 580
            +R + + +   KE+  LE  R+++ A  E+ RR++ EE  ++ L   EE   +R+  L +
Sbjct: 1955 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2014

Query: 581  VLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRK 640
            V + + +VE+ +  +++  ++   Q+    E A++   AEEKA   A  +K +E++   +
Sbjct: 2015 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2074

Query: 641  QEE--------EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER 692
            QE+        EA   R   +E EE R    +Q ++E  Q R R+  EA+RL +Q  +E+
Sbjct: 2075 QEQSVLDQLRGEAEAARRAAEEAEEAR----VQAEREAAQSR-RQVEEAERL-KQSAEEQ 2128

Query: 693  REQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER--EKALRLQKEQ 750
             +   + Q   E+ R+E E+    R  AEQ   R+++   AE E  ++  E+ LR QK Q
Sbjct: 2129 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQ 2187

Query: 751  LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQG 810
            +++EL   + + E+    +  L EE ++   EA  A++  +    V+    +      + 
Sbjct: 2188 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS---QVEEELFSVRVQMEEL 2244

Query: 811  HRAPPKINPDNYGMDLNSDDST----DDEAHPRKPI 842
             +   +I  +N  + L   D+T     +EA   K +
Sbjct: 2245 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2280



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 120/513 (23%), Positives = 221/513 (43%), Gaps = 60/513 (11%)

Query: 299  DSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSY 358
            +SQ  R + +  +S   +V A+  +   KQ ++      RL  + AE      R +  + 
Sbjct: 1510 ESQRKRQAEVELAS---RVKAEAEAAREKQRALQALEELRLQAEEAE------RRLRQAE 1560

Query: 359  LERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
            +ER   V+V  +      E   +++  + AE          S       +A      +  
Sbjct: 1561 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR 1617

Query: 419  ASSPETPSAGQQEA---------KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
            A         ++EA         K ++A   R   +   +++S  QA +E  +E   E E
Sbjct: 1618 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---EAE 1674

Query: 470  ELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMD 529
                 R K         + VR        +++ + L   T+  R   +  +     +R+ 
Sbjct: 1675 REARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL-----IRLR 1723

Query: 530  PKCSFVEKERQRLEN----LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR 585
             +    E++RQ LE     L+R+  A   +RQ++E +    L +V+ + E  L    +A 
Sbjct: 1724 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----LAKVRAEMEVLLASKARAE 1779

Query: 586  ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE- 644
            E      E+ K+++E +  +  E  E+A   R   E+AK++   +  EE  AR++ E E 
Sbjct: 1780 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--QLAEEDAARQRAEAER 1837

Query: 645  --ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER 702
              A +L  + +    +   E+  K+KE E ERLR+ AE +    +R +E+  Q + + E 
Sbjct: 1838 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1897

Query: 703  REQERREQERREQERQ--LAE---QERRREQERLQAERELQEREKA----LRLQKEQLQR 753
            R  + R+    E ERQ  L E   ++RR+ +E + A +   E+  A    L L+  +++ 
Sbjct: 1898 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1957

Query: 754  ELEEKKKKEEQQRL---AERQLQEEQEKKAKEA 783
              E+  + +EQ  L    +RQL  E+E++ +EA
Sbjct: 1958 NAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1990



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 83/295 (28%), Positives = 143/295 (48%), Gaps = 59/295 (20%)

Query: 540  QRLENLRRKEEAEQLRRQKVEED---KRRRLEEVKLKREERLRKVLQARERVE------- 589
            +RL  LR+  ++E  R++ + ED   +RR++EE  L  +    K    +  +E       
Sbjct: 1897 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1956

Query: 590  -----QMKEEKKKQIE----QKFAQIDEKTEKAKEERLAEEKAKKKAAAKK----MEEVE 636
                  ++ +++ ++E    ++ A  +E+  +  EER+ +  A ++ AA++    +EEVE
Sbjct: 1957 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2016

Query: 637  ARRKQEEEARRLRWLQQEE------------------EERRHQELLQKKKEEEQ------ 672
              + + EEARRLR   ++E                  EE+ H   +Q+K++E Q      
Sbjct: 2017 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2076

Query: 673  ----ERLRKAAEAKRLAEQREQERREQERRE--QERR---EQERREQERREQERQLAEQE 723
                ++LR  AEA R A +  +E R Q  RE  Q RR   E ER +Q   EQ +  A+ +
Sbjct: 2077 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2136

Query: 724  RRREQERLQAERELQER---EKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEE 775
               E+ R +AE+E   R   E+A   QK+    E+E+ KK  EQ    + Q+++E
Sbjct: 2137 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2191



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 87/289 (30%), Positives = 146/289 (50%), Gaps = 49/289 (16%)

Query: 539  RQRLENLRRKEEAE---QLRRQKVEEDKRRRLEE------VKLKREERLR-------KVL 582
            ++ L+ LR+  EAE   + R+ +  E  R R+EE      ++L+  ER R       + L
Sbjct: 1423 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1482

Query: 583  QAR-ERVEQMKEEKKKQIEQKFAQIDEKTEKAKE---ERLAEEKAKKKAAAKK---MEEV 635
            +AR E  E  K + +++ E+   Q+ +++++ ++   E  +  KA+ +AA +K   ++ +
Sbjct: 1483 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1542

Query: 636  EARRKQEEEARRLRWLQQEEEERRHQ-----ELLQKKKEEEQERLRKAAEAKRLAEQREQ 690
            E  R Q EEA R   L+Q E ER  Q     E  Q+  E E +  ++A+ A++ A+    
Sbjct: 1543 EELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQS-KRASFAEKTAQLERS 1599

Query: 691  ERREQERREQERREQERREQERREQERQLAEQERRREQE------------RLQAERELQ 738
             + E     Q R E ERR Q++ E ER  A +E  RE E            RLQAE   Q
Sbjct: 1600 LQEEHVAVAQLREEAERRAQQQAEAER--AREEAERELERWQLKANEALRLRLQAEEVAQ 1657

Query: 739  EREKA---LRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 784
            ++  A      QKE+ +RE   + K EE Q + +R+L E++ +K ++ A
Sbjct: 1658 QKSLAQAEAEKQKEEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLA 1705



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 126/557 (22%), Positives = 232/557 (41%), Gaps = 107/557 (19%)

Query: 316  QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
            Q L Q+ S++ +       A+RR A++  E    + R    S   R    E  +   S +
Sbjct: 2071 QTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQS---RRQVEEAERLKQSAE 2126

Query: 376  KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTD 435
            ++    A+  AAAE    E          + E A      + A    +   A  ++ K  
Sbjct: 2127 EQAQARAQAQAAAEKLRKEA---------EQEAARRAQAEQAALRQKQAADAEMEKHKKF 2177

Query: 436  QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV------- 488
                 R+  Q  +   + +  + E D +++L DEELQ  +++   +    S+V       
Sbjct: 2178 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2237

Query: 489  ------VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRL 542
                  +  L+  +    R  +L    +  R + +   K         + S   +E  RL
Sbjct: 2238 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2297

Query: 543  ENLRRKEEAEQ--LRRQKVEEDKRRRLEEVKLKREERLRKVLQ--ARERVEQMKEEKKKQ 598
              L  ++ A+Q  L  + ++E  +   E  +LK E  L +  +  A+E+  +++E+K++ 
Sbjct: 2298 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2357

Query: 599  IEQKFAQID--EKTEKAKEERLAEEKAKKKAAAKKMEEVE-ARRKQEEEARRLRWLQQEE 655
             +Q   +    ++T +A+ +R  E  A+ +    ++ E+  A+ + EE+A+R R   +E 
Sbjct: 2358 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2417

Query: 656  EERRHQ---------------ELLQKKKEEEQERLRKA-AEAKRLAEQREQERR------ 693
             E+ H+               E+ +++ + + ERLR+A AE +R  E+ +QE +      
Sbjct: 2418 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2477

Query: 694  ------------------------------------EQERREQER-------REQERREQ 710
                                                EQE+ + E+       + Q+ RE+
Sbjct: 2478 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2537

Query: 711  ERREQERQLAEQERRR------EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 764
            ++R+Q++   EQER+R      E  R Q E E   R K   LQ+ + QR  +E+   EE 
Sbjct: 2538 QQRQQQQM--EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN 2595

Query: 765  QRLAER-QLQEEQEKKA 780
            QRL E+ QL EEQ + A
Sbjct: 2596 QRLREQLQLLEEQHRAA 2612



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 78/288 (27%), Positives = 146/288 (50%), Gaps = 32/288 (11%)

Query: 543  ENLRRKEEAEQLRRQKVEEDKRRRLE-EVKLKREERLRKV-LQARERVEQMKEEKKKQIE 600
            E LRR EE E+L  Q+  E++ R  E E  L+++ +L +   QA+ + E+  +E +++++
Sbjct: 1343 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1402

Query: 601  QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 660
            ++  + +E    A++++ + ++  ++       E++A+ +Q E A R R L+ EEE R  
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIR-- 1459

Query: 661  QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720
               + + + E  ER R  AE     E +    R +E   Q+R+ QE  E+ RR    Q+ 
Sbjct: 1460 ---VVRLQLEATERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRR----QVQ 1508

Query: 721  EQERRREQ------ERLQAERE-LQEREKA------LRLQKEQLQREL---EEKKKKEEQ 764
            ++ +R+ Q       R++AE E  +E+++A      LRLQ E+ +R L   E ++ ++ Q
Sbjct: 1509 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1568

Query: 765  QRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHR 812
              L   Q   E E ++K A+ A K   +   +Q       Q+  +  R
Sbjct: 1569 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER 1616



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 78/281 (27%), Positives = 133/281 (47%), Gaps = 27/281 (9%)

Query: 535  VEKERQ---RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQM 591
            VE+ RQ    LE  +R  EAE   ++    +K  +LE    +    + ++ +  ER  Q 
Sbjct: 1561 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1620

Query: 592  KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 651
            + E ++  E+   +++    KA E      +A++ A  K + + EA +++EE  R  R  
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1680

Query: 652  QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE--QERREQERREQER------- 702
             + EE+   Q  L +++ E+Q +L +    +RLA ++E  + R E E+ EQ+R       
Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1740

Query: 703  ----REQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE- 757
                RE     Q+R+E E +LA+   R E E L A +   E E     +K + + E E  
Sbjct: 1741 ARLQREAAAATQKRQELEAELAKV--RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1798

Query: 758  --KKKKEEQQRL------AERQLQEEQEKKAKEAAGASKAL 790
              ++  EE  RL      A+RQ Q  +E  A++ A A + L
Sbjct: 1799 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1839



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 126/521 (24%), Positives = 216/521 (41%), Gaps = 80/521 (15%)

Query: 319  AQKYSLVAKQESVVRRASRRLAKK-TAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKE 377
            A++  L A++E   R A  R+ K   AEE AA  R      +ERL       KV  E + 
Sbjct: 1974 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL-----KAKV-EEARR 2027

Query: 378  PPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQA 437
              E AE  +A + ++ +          +   A +    +              +    +A
Sbjct: 2028 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087

Query: 438  DGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLH 497
            +  R   + A   R   +  +     Q  E E L+    +   +   A      LR    
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--- 2144

Query: 498  TVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQ---- 553
              +  Q       A ++ ++   K+     M+    F E      + LR+K + EQ    
Sbjct: 2145 --EAEQEAARRAQAEQAALRQ--KQAADAEMEKHKKFAE------QTLRQKAQVEQELTT 2194

Query: 554  LRRQKVEEDKRRRLEEVKLKR-EERLRKVLQARERVEQMKEEKKKQIEQKF---AQIDEK 609
            LR Q  E D ++ L + +L+R +    +  + R +VE+     + Q+E+     A+I+ +
Sbjct: 2195 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2254

Query: 610  T------EKAKEERLAEEKAKKKAAAKKMEEVEARRK-QEEEARRLRWLQQEEEERRH-- 660
                   +K   +R  +E+A+K    K++ E  AR     +EA RLR L +E+  ++   
Sbjct: 2255 NRALILRDKDNTQRFLQEEAEKM---KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2311

Query: 661  -QELLQKKKEEEQERLRKAAEAKRLAEQR----EQERREQERREQERRE--------QER 707
             +++L++K +  QE  R  AEA+ L +Q+    EQ RR QE +EQ  ++        Q  
Sbjct: 2312 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2371

Query: 708  REQERREQERQLAEQER-------------RREQE----RLQAER--------ELQEREK 742
             E ER+ Q    AE ER             R E++    R QAE         EL  +EK
Sbjct: 2372 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2431

Query: 743  ALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 783
               +Q  ++QR+  +   +  ++ +AE  L+ E+EK  +EA
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAE--LEREKEKLQQEA 2470



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 65/243 (26%), Positives = 118/243 (48%), Gaps = 32/243 (13%)

Query: 578  LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA 637
            + + L+  E  E++ E+++ +  ++ A+++   EK ++  LAE  A+ KA A++  +   
Sbjct: 1341 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ--LAEAHAQAKAQAEREAKELQ 1398

Query: 638  RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 697
            +R QEE  RR       EE     +  ++  +EE ++LR+++EA+  A+ R+ E  E+ R
Sbjct: 1399 QRMQEEVVRR-------EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1451

Query: 698  REQE------RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQ---- 747
               E      R + E  E++R   E +L     R E+   Q +R+ QE  + LR Q    
Sbjct: 1452 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDE 1510

Query: 748  ---KEQLQRELEEKKKKEEQ---------QRLAERQLQEEQEKKAKEAAGASKALNVTVD 795
               K Q + EL  + K E +         Q L E +LQ E+ ++    A   +A  V V 
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1570

Query: 796  VQS 798
            +++
Sbjct: 1571 LET 1573



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 63/289 (21%), Positives = 133/289 (46%), Gaps = 35/289 (12%)

Query: 534  FVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR---KVLQARERVEQ 590
            ++EK +     +R  + AE++ R   E+ K  +     L   E  +   K L+A+   +Q
Sbjct: 1088 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1147

Query: 591  MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA--------RRKQE 642
               +  +   +   ++ E+ ++   ER  E +  ++  A+ +E  +A        +R+ E
Sbjct: 1148 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1207

Query: 643  EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR--EQERREQ 700
            +  R+LR+ + E  +     L   ++ +EQ +    A+++ + EQ  QE+   E+  R  
Sbjct: 1208 QLGRQLRYYR-ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1266

Query: 701  ERREQERREQER-----REQERQLAEQERRRE-------QERLQ--AERELQE------- 739
            E+ E+ +R  ++     ++ E QL   + + E       + ++Q  +E  +QE       
Sbjct: 1267 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1326

Query: 740  REKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788
              +   L  + ++   E  ++ EE++RLAE+Q  EE+E+ A+  A   K
Sbjct: 1327 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1375


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  100 bits (249), Expect = 6e-21
 Identities = 79/271 (29%), Positives = 139/271 (51%), Gaps = 25/271 (9%)

Query: 538  ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERL--------RKVLQARERVE 589
            E    +  + +EEAE+LRRQ  +E +R+R  EV+L    +         ++ LQA E + 
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1542

Query: 590  QMKEEKKKQIEQ----KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA 645
               EE ++++ Q    +  Q+    E A+    AE ++K+ + A+K  ++E  R  +EE 
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE--RSLQEEH 1600

Query: 646  RRLRWLQQEEEERRHQELLQKKKEEEQER-----LRKAAEAKRL---AEQREQERREQER 697
              +  L++E E R  Q+   ++  EE ER       KA EA RL   AE+  Q++   + 
Sbjct: 1601 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1660

Query: 698  REQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 757
              ++++E+  RE  RR +  + A ++R   ++ L+ +R+L E     RL  EQ    L  
Sbjct: 1661 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1720

Query: 758  KKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788
            + ++ EQQR   + L+EE  +  +EAA A++
Sbjct: 1721 ETEQGEQQR---QLLEEELARLQREAAAATQ 1748



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 89/313 (28%), Positives = 153/313 (48%), Gaps = 50/313 (15%)

Query: 524  TPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQ 583
            T L+ + + +  EKE +  E LRR  E E  +R+++EE   +   +++ +R  +LRK   
Sbjct: 1846 TRLKTEAEIALKEKEAEN-ERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASD 1903

Query: 584  AR-ERVEQMKEE---KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARR 639
            +  ER + + E+   +++Q+E++   +    EKA   +   E    +  +   + + ++ 
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963

Query: 640  KQEEEARRLRWLQQEEEERRHQ--ELLQKK--KEEEQERLRKAA------------EAKR 683
            + E EA R R L  EEE RR +  E +QK    EEE  R RKAA            EA+R
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023

Query: 684  LAEQREQERREQ-----------------------ERREQERREQERREQERREQERQLA 720
            L E+ EQE   Q                       +++EQE ++  ++EQ   +Q R  A
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083

Query: 721  EQERR----REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 776
            E  RR     E+ R+QAERE  +  + +  + E+L++  EE+ +   Q + A  +L++E 
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142

Query: 777  EKKAKEAAGASKA 789
            E++A   A A +A
Sbjct: 2143 EQEAARRAQAEQA 2155



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 105/408 (25%), Positives = 178/408 (43%), Gaps = 70/408 (17%)

Query: 430  QEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK---TPSSPCPAS 486
            Q+    QA+  ++  ++ R  R   +A  +   ++ L ++EL+  R     T      A 
Sbjct: 1653 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1712

Query: 487  KVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLR 546
            + +  LR      ++ + L+    A               R+  + +   ++RQ LE   
Sbjct: 1713 QELIRLRAETEQGEQQRQLLEEELA---------------RLQREAAAATQKRQELEAEL 1757

Query: 547  RKEEAEQ----LRRQKVEEDKRRRLEEVKLKREE---RLRKVLQARERVEQMKEEKKKQI 599
             K  AE       + + EE+ R   E+ K + E    R R++ +   R+  + EE K+Q 
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ- 1816

Query: 600  EQKFAQIDEKTEKAKEERLAEEK--AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE-- 655
             ++ A+ D   ++A+ ER+  EK  A  +A   K E   A +++E E  RLR L ++E  
Sbjct: 1817 -RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875

Query: 656  EERRHQELLQKKKEEEQERL---RKAAEA-----KRLAEQREQERREQERR--------- 698
            + RR +E   + K + +ERL   RKA+++     K L E   ++RR+ E           
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935

Query: 699  --------------------EQERREQERREQERREQERQLAEQERRREQERLQAERELQ 738
                                E   R +E+ E E   Q +  AE+ERRR +   + ++ L 
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995

Query: 739  EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE--EQEKKAKEAA 784
              E+A R +K  L+     K K EE +RL ER  QE   Q + A+EAA
Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 102/372 (27%), Positives = 174/372 (46%), Gaps = 35/372 (9%)

Query: 429  QQEAKTDQADGPREPPQSARR-KRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASK 487
            Q++A  ++ +   E  +  +R  + Y  A+ + + +      +L+P      +SP    K
Sbjct: 1250 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-----ASPAKKPK 1304

Query: 488  VVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK--RNTPLRMDPKCSFVEKERQRLENL 545
            V     +    +Q    L T  S   ++   +IK    T  RM+        E +RL   
Sbjct: 1305 VQSGSES---VIQEYVDLRTHYSELTTLTSQYIKFISETLRRME--------EEERLAEQ 1353

Query: 546  RRKEEAEQLRRQKVEEDKRRRLEEVKLK---REERLRKVLQARERVEQM-KEEKKKQIEQ 601
            +R EE E+L   +   +K+R+L E   +   + ER  K LQ R + E + +EE     +Q
Sbjct: 1354 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1413

Query: 602  KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQ 661
            +   I E+ ++ ++   AE +AK    A++ E  E  R + EE  R+  LQ E  ER+  
Sbjct: 1414 QKRSIQEELQQLRQSSEAEIQAK----ARQAEAAERSRLRIEEEIRVVRLQLEATERQ-- 1467

Query: 662  ELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAE 721
               +   E E + LR  AE     +++ QE  E+ RR+ +   Q +R+ E     R  AE
Sbjct: 1468 ---RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524

Query: 722  QERRREQER-LQA--ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 778
             E  RE++R LQA  E  LQ  E   RL++ +++R  + +   E  QR AE +LQ ++  
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1584

Query: 779  KAKEAAGASKAL 790
             A++ A   ++L
Sbjct: 1585 FAEKTAQLERSL 1596



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 78/274 (28%), Positives = 137/274 (50%), Gaps = 26/274 (9%)

Query: 535  VEKERQRLE-----NLRRKEEAEQLRRQKVEEDKRRR-----LEEVKLKREERLRKVLQA 584
            +EK+RQ  E       + + EA++L+++  EE  RR       ++ K   +E L+++ Q+
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1428

Query: 585  RERVEQMKEEKKKQIEQKFAQIDEKTE------KAKEERLAEEKAKKKAAAKKMEEVEAR 638
             E   Q K  + +  E+   +I+E+        +A E +    + + +A   + EE EA+
Sbjct: 1429 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1488

Query: 639  RKQ-EEEARRLRWLQQEEEERRHQ---ELLQKKKEE-----EQERLRKAAEAKRLAEQRE 689
            ++Q +EEA RLR   Q+E +R+ Q   EL  + K E     E++R  +A E  RL  +  
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548

Query: 690  QERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKE 749
            + R  Q   E+ R+ Q   E  +R  E +L  +     ++  Q ER LQE   A+   +E
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608

Query: 750  QLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 783
            + +R  +++ + E  +  AER+L E  + KA EA
Sbjct: 1609 EAERRAQQQAEAERAREEAEREL-ERWQLKANEA 1641



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 88/336 (26%), Positives = 165/336 (49%), Gaps = 29/336 (8%)

Query: 526  LRMDPKCSFVEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRL---EEVKLKREERLRK 580
            +R + + +   KE+  LE  R+++ A  E+ RR++ EE  ++ L   EE   +R+  L +
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010

Query: 581  VLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRK 640
            V + + +VE+ +  +++  ++   Q+    E A++   AEEKA   A  +K +E++   +
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070

Query: 641  QEE--------EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER 692
            QE+        EA   R   +E EE R    +Q ++E  Q R R+  EA+RL +Q  +E+
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEAR----VQAEREAAQSR-RQVEEAERL-KQSAEEQ 2124

Query: 693  REQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER--EKALRLQKEQ 750
             +   + Q   E+ R+E E+    R  AEQ   R+++   AE E  ++  E+ LR QK Q
Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQ 2183

Query: 751  LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQG 810
            +++EL   + + E+    +  L EE ++   EA  A++  +    V+    +      + 
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS---QVEEELFSVRVQMEEL 2240

Query: 811  HRAPPKINPDNYGMDLNSDDST----DDEAHPRKPI 842
             +   +I  +N  + L   D+T     +EA   K +
Sbjct: 2241 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 120/513 (23%), Positives = 221/513 (43%), Gaps = 60/513 (11%)

Query: 299  DSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSY 358
            +SQ  R + +  +S   +V A+  +   KQ ++      RL  + AE      R +  + 
Sbjct: 1506 ESQRKRQAEVELAS---RVKAEAEAAREKQRALQALEELRLQAEEAE------RRLRQAE 1556

Query: 359  LERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
            +ER   V+V  +      E   +++  + AE          S       +A      +  
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR 1613

Query: 419  ASSPETPSAGQQEA---------KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
            A         ++EA         K ++A   R   +   +++S  QA +E  +E   E E
Sbjct: 1614 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---EAE 1670

Query: 470  ELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMD 529
                 R K         + VR        +++ + L   T+  R   +  +     +R+ 
Sbjct: 1671 REARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL-----IRLR 1719

Query: 530  PKCSFVEKERQRLEN----LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR 585
             +    E++RQ LE     L+R+  A   +RQ++E +    L +V+ + E  L    +A 
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----LAKVRAEMEVLLASKARAE 1775

Query: 586  ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE- 644
            E      E+ K+++E +  +  E  E+A   R   E+AK++   +  EE  AR++ E E 
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--QLAEEDAARQRAEAER 1833

Query: 645  --ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER 702
              A +L  + +    +   E+  K+KE E ERLR+ AE +    +R +E+  Q + + E 
Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1893

Query: 703  REQERREQERREQERQ--LAE---QERRREQERLQAERELQEREKA----LRLQKEQLQR 753
            R  + R+    E ERQ  L E   ++RR+ +E + A +   E+  A    L L+  +++ 
Sbjct: 1894 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1953

Query: 754  ELEEKKKKEEQQRL---AERQLQEEQEKKAKEA 783
              E+  + +EQ  L    +RQL  E+E++ +EA
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 83/295 (28%), Positives = 143/295 (48%), Gaps = 59/295 (20%)

Query: 540  QRLENLRRKEEAEQLRRQKVEED---KRRRLEEVKLKREERLRKVLQARERVE------- 589
            +RL  LR+  ++E  R++ + ED   +RR++EE  L  +    K    +  +E       
Sbjct: 1893 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952

Query: 590  -----QMKEEKKKQIE----QKFAQIDEKTEKAKEERLAEEKAKKKAAAKK----MEEVE 636
                  ++ +++ ++E    ++ A  +E+  +  EER+ +  A ++ AA++    +EEVE
Sbjct: 1953 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2012

Query: 637  ARRKQEEEARRLRWLQQEE------------------EERRHQELLQKKKEEEQ------ 672
              + + EEARRLR   ++E                  EE+ H   +Q+K++E Q      
Sbjct: 2013 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2072

Query: 673  ----ERLRKAAEAKRLAEQREQERREQERRE--QERR---EQERREQERREQERQLAEQE 723
                ++LR  AEA R A +  +E R Q  RE  Q RR   E ER +Q   EQ +  A+ +
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132

Query: 724  RRREQERLQAERELQER---EKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEE 775
               E+ R +AE+E   R   E+A   QK+    E+E+ KK  EQ    + Q+++E
Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 87/289 (30%), Positives = 146/289 (50%), Gaps = 49/289 (16%)

Query: 539  RQRLENLRRKEEAE---QLRRQKVEEDKRRRLEE------VKLKREERLR-------KVL 582
            ++ L+ LR+  EAE   + R+ +  E  R R+EE      ++L+  ER R       + L
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478

Query: 583  QAR-ERVEQMKEEKKKQIEQKFAQIDEKTEKAKE---ERLAEEKAKKKAAAKK---MEEV 635
            +AR E  E  K + +++ E+   Q+ +++++ ++   E  +  KA+ +AA +K   ++ +
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1538

Query: 636  EARRKQEEEARRLRWLQQEEEERRHQ-----ELLQKKKEEEQERLRKAAEAKRLAEQREQ 690
            E  R Q EEA R   L+Q E ER  Q     E  Q+  E E +  ++A+ A++ A+    
Sbjct: 1539 EELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQS-KRASFAEKTAQLERS 1595

Query: 691  ERREQERREQERREQERREQERREQERQLAEQERRREQE------------RLQAERELQ 738
             + E     Q R E ERR Q++ E ER  A +E  RE E            RLQAE   Q
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAER--AREEAERELERWQLKANEALRLRLQAEEVAQ 1653

Query: 739  EREKA---LRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 784
            ++  A      QKE+ +RE   + K EE Q + +R+L E++ +K ++ A
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLA 1701



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 126/557 (22%), Positives = 232/557 (41%), Gaps = 107/557 (19%)

Query: 316  QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
            Q L Q+ S++ +       A+RR A++  E    + R    S   R    E  +   S +
Sbjct: 2067 QTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQS---RRQVEEAERLKQSAE 2122

Query: 376  KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTD 435
            ++    A+  AAAE    E          + E A      + A    +   A  ++ K  
Sbjct: 2123 EQAQARAQAQAAAEKLRKEA---------EQEAARRAQAEQAALRQKQAADAEMEKHKKF 2173

Query: 436  QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV------- 488
                 R+  Q  +   + +  + E D +++L DEELQ  +++   +    S+V       
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233

Query: 489  ------VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRL 542
                  +  L+  +    R  +L    +  R + +   K         + S   +E  RL
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293

Query: 543  ENLRRKEEAEQ--LRRQKVEEDKRRRLEEVKLKREERLRKVLQ--ARERVEQMKEEKKKQ 598
              L  ++ A+Q  L  + ++E  +   E  +LK E  L +  +  A+E+  +++E+K++ 
Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353

Query: 599  IEQKFAQID--EKTEKAKEERLAEEKAKKKAAAKKMEEVE-ARRKQEEEARRLRWLQQEE 655
             +Q   +    ++T +A+ +R  E  A+ +    ++ E+  A+ + EE+A+R R   +E 
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413

Query: 656  EERRHQ---------------ELLQKKKEEEQERLRKA-AEAKRLAEQREQERR------ 693
             E+ H+               E+ +++ + + ERLR+A AE +R  E+ +QE +      
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2473

Query: 694  ------------------------------------EQERREQER-------REQERREQ 710
                                                EQE+ + E+       + Q+ RE+
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2533

Query: 711  ERREQERQLAEQERRR------EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 764
            ++R+Q++   EQER+R      E  R Q E E   R K   LQ+ + QR  +E+   EE 
Sbjct: 2534 QQRQQQQM--EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN 2591

Query: 765  QRLAER-QLQEEQEKKA 780
            QRL E+ QL EEQ + A
Sbjct: 2592 QRLREQLQLLEEQHRAA 2608



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 78/288 (27%), Positives = 146/288 (50%), Gaps = 32/288 (11%)

Query: 543  ENLRRKEEAEQLRRQKVEEDKRRRLE-EVKLKREERLRKV-LQARERVEQMKEEKKKQIE 600
            E LRR EE E+L  Q+  E++ R  E E  L+++ +L +   QA+ + E+  +E +++++
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398

Query: 601  QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 660
            ++  + +E    A++++ + ++  ++       E++A+ +Q E A R R L+ EEE R  
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIR-- 1455

Query: 661  QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720
               + + + E  ER R  AE     E +    R +E   Q+R+ QE  E+ RR    Q+ 
Sbjct: 1456 ---VVRLQLEATERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRR----QVQ 1504

Query: 721  EQERRREQ------ERLQAERE-LQEREKA------LRLQKEQLQREL---EEKKKKEEQ 764
            ++ +R+ Q       R++AE E  +E+++A      LRLQ E+ +R L   E ++ ++ Q
Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1564

Query: 765  QRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHR 812
              L   Q   E E ++K A+ A K   +   +Q       Q+  +  R
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER 1612



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 78/281 (27%), Positives = 133/281 (47%), Gaps = 27/281 (9%)

Query: 535  VEKERQ---RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQM 591
            VE+ RQ    LE  +R  EAE   ++    +K  +LE    +    + ++ +  ER  Q 
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 592  KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 651
            + E ++  E+   +++    KA E      +A++ A  K + + EA +++EE  R  R  
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676

Query: 652  QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE--QERREQERREQER------- 702
             + EE+   Q  L +++ E+Q +L +    +RLA ++E  + R E E+ EQ+R       
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736

Query: 703  ----REQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE- 757
                RE     Q+R+E E +LA+   R E E L A +   E E     +K + + E E  
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKV--RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794

Query: 758  --KKKKEEQQRL------AERQLQEEQEKKAKEAAGASKAL 790
              ++  EE  RL      A+RQ Q  +E  A++ A A + L
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1835



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 126/521 (24%), Positives = 216/521 (41%), Gaps = 80/521 (15%)

Query: 319  AQKYSLVAKQESVVRRASRRLAKK-TAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKE 377
            A++  L A++E   R A  R+ K   AEE AA  R      +ERL       KV  E + 
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL-----KAKV-EEARR 2023

Query: 378  PPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQA 437
              E AE  +A + ++ +          +   A +    +              +    +A
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083

Query: 438  DGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLH 497
            +  R   + A   R   +  +     Q  E E L+    +   +   A      LR    
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--- 2140

Query: 498  TVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQ---- 553
              +  Q       A ++ ++   K+     M+    F E      + LR+K + EQ    
Sbjct: 2141 --EAEQEAARRAQAEQAALRQ--KQAADAEMEKHKKFAE------QTLRQKAQVEQELTT 2190

Query: 554  LRRQKVEEDKRRRLEEVKLKR-EERLRKVLQARERVEQMKEEKKKQIEQKF---AQIDEK 609
            LR Q  E D ++ L + +L+R +    +  + R +VE+     + Q+E+     A+I+ +
Sbjct: 2191 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2250

Query: 610  T------EKAKEERLAEEKAKKKAAAKKMEEVEARRK-QEEEARRLRWLQQEEEERRH-- 660
                   +K   +R  +E+A+K    K++ E  AR     +EA RLR L +E+  ++   
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKM---KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307

Query: 661  -QELLQKKKEEEQERLRKAAEAKRLAEQR----EQERREQERREQERRE--------QER 707
             +++L++K +  QE  R  AEA+ L +Q+    EQ RR QE +EQ  ++        Q  
Sbjct: 2308 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2367

Query: 708  REQERREQERQLAEQER-------------RREQE----RLQAER--------ELQEREK 742
             E ER+ Q    AE ER             R E++    R QAE         EL  +EK
Sbjct: 2368 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427

Query: 743  ALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 783
               +Q  ++QR+  +   +  ++ +AE  L+ E+EK  +EA
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAE--LEREKEKLQQEA 2466



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 65/243 (26%), Positives = 118/243 (48%), Gaps = 32/243 (13%)

Query: 578  LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA 637
            + + L+  E  E++ E+++ +  ++ A+++   EK ++  LAE  A+ KA A++  +   
Sbjct: 1337 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ--LAEAHAQAKAQAEREAKELQ 1394

Query: 638  RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 697
            +R QEE  RR       EE     +  ++  +EE ++LR+++EA+  A+ R+ E  E+ R
Sbjct: 1395 QRMQEEVVRR-------EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447

Query: 698  REQE------RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQ---- 747
               E      R + E  E++R   E +L     R E+   Q +R+ QE  + LR Q    
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDE 1506

Query: 748  ---KEQLQRELEEKKKKEEQ---------QRLAERQLQEEQEKKAKEAAGASKALNVTVD 795
               K Q + EL  + K E +         Q L E +LQ E+ ++    A   +A  V V 
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566

Query: 796  VQS 798
            +++
Sbjct: 1567 LET 1569



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 63/289 (21%), Positives = 133/289 (46%), Gaps = 35/289 (12%)

Query: 534  FVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR---KVLQARERVEQ 590
            ++EK +     +R  + AE++ R   E+ K  +     L   E  +   K L+A+   +Q
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1143

Query: 591  MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA--------RRKQE 642
               +  +   +   ++ E+ ++   ER  E +  ++  A+ +E  +A        +R+ E
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1203

Query: 643  EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR--EQERREQ 700
            +  R+LR+ + E  +     L   ++ +EQ +    A+++ + EQ  QE+   E+  R  
Sbjct: 1204 QLGRQLRYYR-ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1262

Query: 701  ERREQERREQER-----REQERQLAEQERRRE-------QERLQ--AERELQE------- 739
            E+ E+ +R  ++     ++ E QL   + + E       + ++Q  +E  +QE       
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322

Query: 740  REKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788
              +   L  + ++   E  ++ EE++RLAE+Q  EE+E+ A+  A   K
Sbjct: 1323 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1371


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  100 bits (249), Expect = 6e-21
 Identities = 79/271 (29%), Positives = 139/271 (51%), Gaps = 25/271 (9%)

Query: 538  ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERL--------RKVLQARERVE 589
            E    +  + +EEAE+LRRQ  +E +R+R  EV+L    +         ++ LQA E + 
Sbjct: 1451 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1510

Query: 590  QMKEEKKKQIEQ----KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA 645
               EE ++++ Q    +  Q+    E A+    AE ++K+ + A+K  ++E  R  +EE 
Sbjct: 1511 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE--RSLQEEH 1568

Query: 646  RRLRWLQQEEEERRHQELLQKKKEEEQER-----LRKAAEAKRL---AEQREQERREQER 697
              +  L++E E R  Q+   ++  EE ER       KA EA RL   AE+  Q++   + 
Sbjct: 1569 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1628

Query: 698  REQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 757
              ++++E+  RE  RR +  + A ++R   ++ L+ +R+L E     RL  EQ    L  
Sbjct: 1629 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1688

Query: 758  KKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788
            + ++ EQQR   + L+EE  +  +EAA A++
Sbjct: 1689 ETEQGEQQR---QLLEEELARLQREAAAATQ 1716



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 89/313 (28%), Positives = 153/313 (48%), Gaps = 50/313 (15%)

Query: 524  TPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQ 583
            T L+ + + +  EKE +  E LRR  E E  +R+++EE   +   +++ +R  +LRK   
Sbjct: 1814 TRLKTEAEIALKEKEAEN-ERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASD 1871

Query: 584  AR-ERVEQMKEE---KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARR 639
            +  ER + + E+   +++Q+E++   +    EKA   +   E    +  +   + + ++ 
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1931

Query: 640  KQEEEARRLRWLQQEEEERRHQ--ELLQKK--KEEEQERLRKAA------------EAKR 683
            + E EA R R L  EEE RR +  E +QK    EEE  R RKAA            EA+R
Sbjct: 1932 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 1991

Query: 684  LAEQREQERREQ-----------------------ERREQERREQERREQERREQERQLA 720
            L E+ EQE   Q                       +++EQE ++  ++EQ   +Q R  A
Sbjct: 1992 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2051

Query: 721  EQERR----REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 776
            E  RR     E+ R+QAERE  +  + +  + E+L++  EE+ +   Q + A  +L++E 
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEA 2110

Query: 777  EKKAKEAAGASKA 789
            E++A   A A +A
Sbjct: 2111 EQEAARRAQAEQA 2123



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 105/408 (25%), Positives = 178/408 (43%), Gaps = 70/408 (17%)

Query: 430  QEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK---TPSSPCPAS 486
            Q+    QA+  ++  ++ R  R   +A  +   ++ L ++EL+  R     T      A 
Sbjct: 1621 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1680

Query: 487  KVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLR 546
            + +  LR      ++ + L+    A               R+  + +   ++RQ LE   
Sbjct: 1681 QELIRLRAETEQGEQQRQLLEEELA---------------RLQREAAAATQKRQELEAEL 1725

Query: 547  RKEEAEQ----LRRQKVEEDKRRRLEEVKLKREE---RLRKVLQARERVEQMKEEKKKQI 599
             K  AE       + + EE+ R   E+ K + E    R R++ +   R+  + EE K+Q 
Sbjct: 1726 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ- 1784

Query: 600  EQKFAQIDEKTEKAKEERLAEEK--AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE-- 655
             ++ A+ D   ++A+ ER+  EK  A  +A   K E   A +++E E  RLR L ++E  
Sbjct: 1785 -RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1843

Query: 656  EERRHQELLQKKKEEEQERL---RKAAEA-----KRLAEQREQERREQERR--------- 698
            + RR +E   + K + +ERL   RKA+++     K L E   ++RR+ E           
Sbjct: 1844 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1903

Query: 699  --------------------EQERREQERREQERREQERQLAEQERRREQERLQAERELQ 738
                                E   R +E+ E E   Q +  AE+ERRR +   + ++ L 
Sbjct: 1904 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1963

Query: 739  EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE--EQEKKAKEAA 784
              E+A R +K  L+     K K EE +RL ER  QE   Q + A+EAA
Sbjct: 1964 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2011



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 102/372 (27%), Positives = 174/372 (46%), Gaps = 35/372 (9%)

Query: 429  QQEAKTDQADGPREPPQSARR-KRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASK 487
            Q++A  ++ +   E  +  +R  + Y  A+ + + +      +L+P      +SP    K
Sbjct: 1218 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-----ASPAKKPK 1272

Query: 488  VVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK--RNTPLRMDPKCSFVEKERQRLENL 545
            V     +    +Q    L T  S   ++   +IK    T  RM+        E +RL   
Sbjct: 1273 VQSGSES---VIQEYVDLRTHYSELTTLTSQYIKFISETLRRME--------EEERLAEQ 1321

Query: 546  RRKEEAEQLRRQKVEEDKRRRLEEVKLK---REERLRKVLQARERVEQM-KEEKKKQIEQ 601
            +R EE E+L   +   +K+R+L E   +   + ER  K LQ R + E + +EE     +Q
Sbjct: 1322 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1381

Query: 602  KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQ 661
            +   I E+ ++ ++   AE +AK    A++ E  E  R + EE  R+  LQ E  ER+  
Sbjct: 1382 QKRSIQEELQQLRQSSEAEIQAK----ARQAEAAERSRLRIEEEIRVVRLQLEATERQ-- 1435

Query: 662  ELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAE 721
               +   E E + LR  AE     +++ QE  E+ RR+ +   Q +R+ E     R  AE
Sbjct: 1436 ---RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1492

Query: 722  QERRREQER-LQA--ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 778
             E  RE++R LQA  E  LQ  E   RL++ +++R  + +   E  QR AE +LQ ++  
Sbjct: 1493 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1552

Query: 779  KAKEAAGASKAL 790
             A++ A   ++L
Sbjct: 1553 FAEKTAQLERSL 1564



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 78/274 (28%), Positives = 137/274 (50%), Gaps = 26/274 (9%)

Query: 535  VEKERQRLE-----NLRRKEEAEQLRRQKVEEDKRRR-----LEEVKLKREERLRKVLQA 584
            +EK+RQ  E       + + EA++L+++  EE  RR       ++ K   +E L+++ Q+
Sbjct: 1337 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1396

Query: 585  RERVEQMKEEKKKQIEQKFAQIDEKTE------KAKEERLAEEKAKKKAAAKKMEEVEAR 638
             E   Q K  + +  E+   +I+E+        +A E +    + + +A   + EE EA+
Sbjct: 1397 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1456

Query: 639  RKQ-EEEARRLRWLQQEEEERRHQ---ELLQKKKEE-----EQERLRKAAEAKRLAEQRE 689
            ++Q +EEA RLR   Q+E +R+ Q   EL  + K E     E++R  +A E  RL  +  
Sbjct: 1457 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1516

Query: 690  QERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKE 749
            + R  Q   E+ R+ Q   E  +R  E +L  +     ++  Q ER LQE   A+   +E
Sbjct: 1517 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1576

Query: 750  QLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 783
            + +R  +++ + E  +  AER+L E  + KA EA
Sbjct: 1577 EAERRAQQQAEAERAREEAEREL-ERWQLKANEA 1609



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 88/336 (26%), Positives = 165/336 (49%), Gaps = 29/336 (8%)

Query: 526  LRMDPKCSFVEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRL---EEVKLKREERLRK 580
            +R + + +   KE+  LE  R+++ A  E+ RR++ EE  ++ L   EE   +R+  L +
Sbjct: 1919 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1978

Query: 581  VLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRK 640
            V + + +VE+ +  +++  ++   Q+    E A++   AEEKA   A  +K +E++   +
Sbjct: 1979 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2038

Query: 641  QEE--------EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER 692
            QE+        EA   R   +E EE R    +Q ++E  Q R R+  EA+RL +Q  +E+
Sbjct: 2039 QEQSVLDQLRGEAEAARRAAEEAEEAR----VQAEREAAQSR-RQVEEAERL-KQSAEEQ 2092

Query: 693  REQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER--EKALRLQKEQ 750
             +   + Q   E+ R+E E+    R  AEQ   R+++   AE E  ++  E+ LR QK Q
Sbjct: 2093 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQ 2151

Query: 751  LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQG 810
            +++EL   + + E+    +  L EE ++   EA  A++  +    V+    +      + 
Sbjct: 2152 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS---QVEEELFSVRVQMEEL 2208

Query: 811  HRAPPKINPDNYGMDLNSDDST----DDEAHPRKPI 842
             +   +I  +N  + L   D+T     +EA   K +
Sbjct: 2209 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2244



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 120/513 (23%), Positives = 221/513 (43%), Gaps = 60/513 (11%)

Query: 299  DSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSY 358
            +SQ  R + +  +S   +V A+  +   KQ ++      RL  + AE      R +  + 
Sbjct: 1474 ESQRKRQAEVELAS---RVKAEAEAAREKQRALQALEELRLQAEEAE------RRLRQAE 1524

Query: 359  LERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
            +ER   V+V  +      E   +++  + AE          S       +A      +  
Sbjct: 1525 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR 1581

Query: 419  ASSPETPSAGQQEA---------KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
            A         ++EA         K ++A   R   +   +++S  QA +E  +E   E E
Sbjct: 1582 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---EAE 1638

Query: 470  ELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMD 529
                 R K         + VR        +++ + L   T+  R   +  +     +R+ 
Sbjct: 1639 REARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL-----IRLR 1687

Query: 530  PKCSFVEKERQRLEN----LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR 585
             +    E++RQ LE     L+R+  A   +RQ++E +    L +V+ + E  L    +A 
Sbjct: 1688 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----LAKVRAEMEVLLASKARAE 1743

Query: 586  ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE- 644
            E      E+ K+++E +  +  E  E+A   R   E+AK++   +  EE  AR++ E E 
Sbjct: 1744 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--QLAEEDAARQRAEAER 1801

Query: 645  --ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER 702
              A +L  + +    +   E+  K+KE E ERLR+ AE +    +R +E+  Q + + E 
Sbjct: 1802 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1861

Query: 703  REQERREQERREQERQ--LAE---QERRREQERLQAERELQEREKA----LRLQKEQLQR 753
            R  + R+    E ERQ  L E   ++RR+ +E + A +   E+  A    L L+  +++ 
Sbjct: 1862 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1921

Query: 754  ELEEKKKKEEQQRL---AERQLQEEQEKKAKEA 783
              E+  + +EQ  L    +RQL  E+E++ +EA
Sbjct: 1922 NAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1954



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 83/295 (28%), Positives = 143/295 (48%), Gaps = 59/295 (20%)

Query: 540  QRLENLRRKEEAEQLRRQKVEED---KRRRLEEVKLKREERLRKVLQARERVE------- 589
            +RL  LR+  ++E  R++ + ED   +RR++EE  L  +    K    +  +E       
Sbjct: 1861 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1920

Query: 590  -----QMKEEKKKQIE----QKFAQIDEKTEKAKEERLAEEKAKKKAAAKK----MEEVE 636
                  ++ +++ ++E    ++ A  +E+  +  EER+ +  A ++ AA++    +EEVE
Sbjct: 1921 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 1980

Query: 637  ARRKQEEEARRLRWLQQEE------------------EERRHQELLQKKKEEEQ------ 672
              + + EEARRLR   ++E                  EE+ H   +Q+K++E Q      
Sbjct: 1981 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2040

Query: 673  ----ERLRKAAEAKRLAEQREQERREQERRE--QERR---EQERREQERREQERQLAEQE 723
                ++LR  AEA R A +  +E R Q  RE  Q RR   E ER +Q   EQ +  A+ +
Sbjct: 2041 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2100

Query: 724  RRREQERLQAERELQER---EKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEE 775
               E+ R +AE+E   R   E+A   QK+    E+E+ KK  EQ    + Q+++E
Sbjct: 2101 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2155



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 87/289 (30%), Positives = 146/289 (50%), Gaps = 49/289 (16%)

Query: 539  RQRLENLRRKEEAE---QLRRQKVEEDKRRRLEE------VKLKREERLR-------KVL 582
            ++ L+ LR+  EAE   + R+ +  E  R R+EE      ++L+  ER R       + L
Sbjct: 1387 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1446

Query: 583  QAR-ERVEQMKEEKKKQIEQKFAQIDEKTEKAKE---ERLAEEKAKKKAAAKK---MEEV 635
            +AR E  E  K + +++ E+   Q+ +++++ ++   E  +  KA+ +AA +K   ++ +
Sbjct: 1447 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1506

Query: 636  EARRKQEEEARRLRWLQQEEEERRHQ-----ELLQKKKEEEQERLRKAAEAKRLAEQREQ 690
            E  R Q EEA R   L+Q E ER  Q     E  Q+  E E +  ++A+ A++ A+    
Sbjct: 1507 EELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQS-KRASFAEKTAQLERS 1563

Query: 691  ERREQERREQERREQERREQERREQERQLAEQERRREQE------------RLQAERELQ 738
             + E     Q R E ERR Q++ E ER  A +E  RE E            RLQAE   Q
Sbjct: 1564 LQEEHVAVAQLREEAERRAQQQAEAER--AREEAERELERWQLKANEALRLRLQAEEVAQ 1621

Query: 739  EREKA---LRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 784
            ++  A      QKE+ +RE   + K EE Q + +R+L E++ +K ++ A
Sbjct: 1622 QKSLAQAEAEKQKEEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLA 1669



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 126/557 (22%), Positives = 232/557 (41%), Gaps = 107/557 (19%)

Query: 316  QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
            Q L Q+ S++ +       A+RR A++  E    + R    S   R    E  +   S +
Sbjct: 2035 QTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQS---RRQVEEAERLKQSAE 2090

Query: 376  KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTD 435
            ++    A+  AAAE    E          + E A      + A    +   A  ++ K  
Sbjct: 2091 EQAQARAQAQAAAEKLRKEA---------EQEAARRAQAEQAALRQKQAADAEMEKHKKF 2141

Query: 436  QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV------- 488
                 R+  Q  +   + +  + E D +++L DEELQ  +++   +    S+V       
Sbjct: 2142 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2201

Query: 489  ------VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRL 542
                  +  L+  +    R  +L    +  R + +   K         + S   +E  RL
Sbjct: 2202 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2261

Query: 543  ENLRRKEEAEQ--LRRQKVEEDKRRRLEEVKLKREERLRKVLQ--ARERVEQMKEEKKKQ 598
              L  ++ A+Q  L  + ++E  +   E  +LK E  L +  +  A+E+  +++E+K++ 
Sbjct: 2262 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2321

Query: 599  IEQKFAQID--EKTEKAKEERLAEEKAKKKAAAKKMEEVE-ARRKQEEEARRLRWLQQEE 655
             +Q   +    ++T +A+ +R  E  A+ +    ++ E+  A+ + EE+A+R R   +E 
Sbjct: 2322 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2381

Query: 656  EERRHQ---------------ELLQKKKEEEQERLRKA-AEAKRLAEQREQERR------ 693
             E+ H+               E+ +++ + + ERLR+A AE +R  E+ +QE +      
Sbjct: 2382 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2441

Query: 694  ------------------------------------EQERREQER-------REQERREQ 710
                                                EQE+ + E+       + Q+ RE+
Sbjct: 2442 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2501

Query: 711  ERREQERQLAEQERRR------EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 764
            ++R+Q++   EQER+R      E  R Q E E   R K   LQ+ + QR  +E+   EE 
Sbjct: 2502 QQRQQQQM--EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN 2559

Query: 765  QRLAER-QLQEEQEKKA 780
            QRL E+ QL EEQ + A
Sbjct: 2560 QRLREQLQLLEEQHRAA 2576



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 78/288 (27%), Positives = 146/288 (50%), Gaps = 32/288 (11%)

Query: 543  ENLRRKEEAEQLRRQKVEEDKRRRLE-EVKLKREERLRKV-LQARERVEQMKEEKKKQIE 600
            E LRR EE E+L  Q+  E++ R  E E  L+++ +L +   QA+ + E+  +E +++++
Sbjct: 1307 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1366

Query: 601  QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 660
            ++  + +E    A++++ + ++  ++       E++A+ +Q E A R R L+ EEE R  
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIR-- 1423

Query: 661  QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720
               + + + E  ER R  AE     E +    R +E   Q+R+ QE  E+ RR    Q+ 
Sbjct: 1424 ---VVRLQLEATERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRR----QVQ 1472

Query: 721  EQERRREQ------ERLQAERE-LQEREKA------LRLQKEQLQREL---EEKKKKEEQ 764
            ++ +R+ Q       R++AE E  +E+++A      LRLQ E+ +R L   E ++ ++ Q
Sbjct: 1473 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1532

Query: 765  QRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHR 812
              L   Q   E E ++K A+ A K   +   +Q       Q+  +  R
Sbjct: 1533 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER 1580



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 78/281 (27%), Positives = 133/281 (47%), Gaps = 27/281 (9%)

Query: 535  VEKERQ---RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQM 591
            VE+ RQ    LE  +R  EAE   ++    +K  +LE    +    + ++ +  ER  Q 
Sbjct: 1525 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1584

Query: 592  KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 651
            + E ++  E+   +++    KA E      +A++ A  K + + EA +++EE  R  R  
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1644

Query: 652  QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE--QERREQERREQER------- 702
             + EE+   Q  L +++ E+Q +L +    +RLA ++E  + R E E+ EQ+R       
Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1704

Query: 703  ----REQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE- 757
                RE     Q+R+E E +LA+   R E E L A +   E E     +K + + E E  
Sbjct: 1705 ARLQREAAAATQKRQELEAELAKV--RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1762

Query: 758  --KKKKEEQQRL------AERQLQEEQEKKAKEAAGASKAL 790
              ++  EE  RL      A+RQ Q  +E  A++ A A + L
Sbjct: 1763 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1803



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 126/521 (24%), Positives = 216/521 (41%), Gaps = 80/521 (15%)

Query: 319  AQKYSLVAKQESVVRRASRRLAKK-TAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKE 377
            A++  L A++E   R A  R+ K   AEE AA  R      +ERL       KV  E + 
Sbjct: 1938 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL-----KAKV-EEARR 1991

Query: 378  PPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQA 437
              E AE  +A + ++ +          +   A +    +              +    +A
Sbjct: 1992 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2051

Query: 438  DGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLH 497
            +  R   + A   R   +  +     Q  E E L+    +   +   A      LR    
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--- 2108

Query: 498  TVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQ---- 553
              +  Q       A ++ ++   K+     M+    F E      + LR+K + EQ    
Sbjct: 2109 --EAEQEAARRAQAEQAALRQ--KQAADAEMEKHKKFAE------QTLRQKAQVEQELTT 2158

Query: 554  LRRQKVEEDKRRRLEEVKLKR-EERLRKVLQARERVEQMKEEKKKQIEQKF---AQIDEK 609
            LR Q  E D ++ L + +L+R +    +  + R +VE+     + Q+E+     A+I+ +
Sbjct: 2159 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2218

Query: 610  T------EKAKEERLAEEKAKKKAAAKKMEEVEARRK-QEEEARRLRWLQQEEEERRH-- 660
                   +K   +R  +E+A+K    K++ E  AR     +EA RLR L +E+  ++   
Sbjct: 2219 NRALILRDKDNTQRFLQEEAEKM---KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2275

Query: 661  -QELLQKKKEEEQERLRKAAEAKRLAEQR----EQERREQERREQERRE--------QER 707
             +++L++K +  QE  R  AEA+ L +Q+    EQ RR QE +EQ  ++        Q  
Sbjct: 2276 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2335

Query: 708  REQERREQERQLAEQER-------------RREQE----RLQAER--------ELQEREK 742
             E ER+ Q    AE ER             R E++    R QAE         EL  +EK
Sbjct: 2336 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2395

Query: 743  ALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 783
               +Q  ++QR+  +   +  ++ +AE  L+ E+EK  +EA
Sbjct: 2396 VTLVQTLEIQRQQSDHDAERLREAIAE--LEREKEKLQQEA 2434



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 65/243 (26%), Positives = 118/243 (48%), Gaps = 32/243 (13%)

Query: 578  LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA 637
            + + L+  E  E++ E+++ +  ++ A+++   EK ++  LAE  A+ KA A++  +   
Sbjct: 1305 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ--LAEAHAQAKAQAEREAKELQ 1362

Query: 638  RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 697
            +R QEE  RR       EE     +  ++  +EE ++LR+++EA+  A+ R+ E  E+ R
Sbjct: 1363 QRMQEEVVRR-------EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1415

Query: 698  REQE------RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQ---- 747
               E      R + E  E++R   E +L     R E+   Q +R+ QE  + LR Q    
Sbjct: 1416 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDE 1474

Query: 748  ---KEQLQRELEEKKKKEEQ---------QRLAERQLQEEQEKKAKEAAGASKALNVTVD 795
               K Q + EL  + K E +         Q L E +LQ E+ ++    A   +A  V V 
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1534

Query: 796  VQS 798
            +++
Sbjct: 1535 LET 1537



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 63/289 (21%), Positives = 133/289 (46%), Gaps = 35/289 (12%)

Query: 534  FVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR---KVLQARERVEQ 590
            ++EK +     +R  + AE++ R   E+ K  +     L   E  +   K L+A+   +Q
Sbjct: 1052 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1111

Query: 591  MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA--------RRKQE 642
               +  +   +   ++ E+ ++   ER  E +  ++  A+ +E  +A        +R+ E
Sbjct: 1112 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1171

Query: 643  EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR--EQERREQ 700
            +  R+LR+ + E  +     L   ++ +EQ +    A+++ + EQ  QE+   E+  R  
Sbjct: 1172 QLGRQLRYYR-ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1230

Query: 701  ERREQERREQER-----REQERQLAEQERRRE-------QERLQ--AERELQE------- 739
            E+ E+ +R  ++     ++ E QL   + + E       + ++Q  +E  +QE       
Sbjct: 1231 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1290

Query: 740  REKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788
              +   L  + ++   E  ++ EE++RLAE+Q  EE+E+ A+  A   K
Sbjct: 1291 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1339


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  100 bits (249), Expect = 6e-21
 Identities = 79/271 (29%), Positives = 139/271 (51%), Gaps = 25/271 (9%)

Query: 538  ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERL--------RKVLQARERVE 589
            E    +  + +EEAE+LRRQ  +E +R+R  EV+L    +         ++ LQA E + 
Sbjct: 1620 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1679

Query: 590  QMKEEKKKQIEQ----KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA 645
               EE ++++ Q    +  Q+    E A+    AE ++K+ + A+K  ++E  R  +EE 
Sbjct: 1680 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE--RSLQEEH 1737

Query: 646  RRLRWLQQEEEERRHQELLQKKKEEEQER-----LRKAAEAKRL---AEQREQERREQER 697
              +  L++E E R  Q+   ++  EE ER       KA EA RL   AE+  Q++   + 
Sbjct: 1738 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1797

Query: 698  REQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 757
              ++++E+  RE  RR +  + A ++R   ++ L+ +R+L E     RL  EQ    L  
Sbjct: 1798 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1857

Query: 758  KKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788
            + ++ EQQR   + L+EE  +  +EAA A++
Sbjct: 1858 ETEQGEQQR---QLLEEELARLQREAAAATQ 1885



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 89/313 (28%), Positives = 153/313 (48%), Gaps = 50/313 (15%)

Query: 524  TPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQ 583
            T L+ + + +  EKE +  E LRR  E E  +R+++EE   +   +++ +R  +LRK   
Sbjct: 1983 TRLKTEAEIALKEKEAEN-ERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASD 2040

Query: 584  AR-ERVEQMKEE---KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARR 639
            +  ER + + E+   +++Q+E++   +    EKA   +   E    +  +   + + ++ 
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100

Query: 640  KQEEEARRLRWLQQEEEERRHQ--ELLQKK--KEEEQERLRKAA------------EAKR 683
            + E EA R R L  EEE RR +  E +QK    EEE  R RKAA            EA+R
Sbjct: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2160

Query: 684  LAEQREQERREQ-----------------------ERREQERREQERREQERREQERQLA 720
            L E+ EQE   Q                       +++EQE ++  ++EQ   +Q R  A
Sbjct: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220

Query: 721  EQERR----REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 776
            E  RR     E+ R+QAERE  +  + +  + E+L++  EE+ +   Q + A  +L++E 
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEA 2279

Query: 777  EKKAKEAAGASKA 789
            E++A   A A +A
Sbjct: 2280 EQEAARRAQAEQA 2292



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 105/408 (25%), Positives = 178/408 (43%), Gaps = 70/408 (17%)

Query: 430  QEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK---TPSSPCPAS 486
            Q+    QA+  ++  ++ R  R   +A  +   ++ L ++EL+  R     T      A 
Sbjct: 1790 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1849

Query: 487  KVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLR 546
            + +  LR      ++ + L+    A               R+  + +   ++RQ LE   
Sbjct: 1850 QELIRLRAETEQGEQQRQLLEEELA---------------RLQREAAAATQKRQELEAEL 1894

Query: 547  RKEEAEQ----LRRQKVEEDKRRRLEEVKLKREE---RLRKVLQARERVEQMKEEKKKQI 599
             K  AE       + + EE+ R   E+ K + E    R R++ +   R+  + EE K+Q 
Sbjct: 1895 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ- 1953

Query: 600  EQKFAQIDEKTEKAKEERLAEEK--AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE-- 655
             ++ A+ D   ++A+ ER+  EK  A  +A   K E   A +++E E  RLR L ++E  
Sbjct: 1954 -RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 2012

Query: 656  EERRHQELLQKKKEEEQERL---RKAAEA-----KRLAEQREQERREQERR--------- 698
            + RR +E   + K + +ERL   RKA+++     K L E   ++RR+ E           
Sbjct: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 2072

Query: 699  --------------------EQERREQERREQERREQERQLAEQERRREQERLQAERELQ 738
                                E   R +E+ E E   Q +  AE+ERRR +   + ++ L 
Sbjct: 2073 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2132

Query: 739  EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE--EQEKKAKEAA 784
              E+A R +K  L+     K K EE +RL ER  QE   Q + A+EAA
Sbjct: 2133 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2180



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 102/372 (27%), Positives = 174/372 (46%), Gaps = 35/372 (9%)

Query: 429  QQEAKTDQADGPREPPQSARR-KRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASK 487
            Q++A  ++ +   E  +  +R  + Y  A+ + + +      +L+P      +SP    K
Sbjct: 1387 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-----ASPAKKPK 1441

Query: 488  VVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK--RNTPLRMDPKCSFVEKERQRLENL 545
            V     +    +Q    L T  S   ++   +IK    T  RM+        E +RL   
Sbjct: 1442 VQSGSES---VIQEYVDLRTHYSELTTLTSQYIKFISETLRRME--------EEERLAEQ 1490

Query: 546  RRKEEAEQLRRQKVEEDKRRRLEEVKLK---REERLRKVLQARERVEQM-KEEKKKQIEQ 601
            +R EE E+L   +   +K+R+L E   +   + ER  K LQ R + E + +EE     +Q
Sbjct: 1491 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1550

Query: 602  KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQ 661
            +   I E+ ++ ++   AE +AK    A++ E  E  R + EE  R+  LQ E  ER+  
Sbjct: 1551 QKRSIQEELQQLRQSSEAEIQAK----ARQAEAAERSRLRIEEEIRVVRLQLEATERQ-- 1604

Query: 662  ELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAE 721
               +   E E + LR  AE     +++ QE  E+ RR+ +   Q +R+ E     R  AE
Sbjct: 1605 ---RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1661

Query: 722  QERRREQER-LQA--ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 778
             E  RE++R LQA  E  LQ  E   RL++ +++R  + +   E  QR AE +LQ ++  
Sbjct: 1662 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1721

Query: 779  KAKEAAGASKAL 790
             A++ A   ++L
Sbjct: 1722 FAEKTAQLERSL 1733



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 78/274 (28%), Positives = 137/274 (50%), Gaps = 26/274 (9%)

Query: 535  VEKERQRLE-----NLRRKEEAEQLRRQKVEEDKRRR-----LEEVKLKREERLRKVLQA 584
            +EK+RQ  E       + + EA++L+++  EE  RR       ++ K   +E L+++ Q+
Sbjct: 1506 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1565

Query: 585  RERVEQMKEEKKKQIEQKFAQIDEKTE------KAKEERLAEEKAKKKAAAKKMEEVEAR 638
             E   Q K  + +  E+   +I+E+        +A E +    + + +A   + EE EA+
Sbjct: 1566 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1625

Query: 639  RKQ-EEEARRLRWLQQEEEERRHQ---ELLQKKKEE-----EQERLRKAAEAKRLAEQRE 689
            ++Q +EEA RLR   Q+E +R+ Q   EL  + K E     E++R  +A E  RL  +  
Sbjct: 1626 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1685

Query: 690  QERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKE 749
            + R  Q   E+ R+ Q   E  +R  E +L  +     ++  Q ER LQE   A+   +E
Sbjct: 1686 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1745

Query: 750  QLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 783
            + +R  +++ + E  +  AER+L E  + KA EA
Sbjct: 1746 EAERRAQQQAEAERAREEAEREL-ERWQLKANEA 1778



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 88/336 (26%), Positives = 165/336 (49%), Gaps = 29/336 (8%)

Query: 526  LRMDPKCSFVEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRL---EEVKLKREERLRK 580
            +R + + +   KE+  LE  R+++ A  E+ RR++ EE  ++ L   EE   +R+  L +
Sbjct: 2088 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2147

Query: 581  VLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRK 640
            V + + +VE+ +  +++  ++   Q+    E A++   AEEKA   A  +K +E++   +
Sbjct: 2148 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2207

Query: 641  QEE--------EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER 692
            QE+        EA   R   +E EE R    +Q ++E  Q R R+  EA+RL +Q  +E+
Sbjct: 2208 QEQSVLDQLRGEAEAARRAAEEAEEAR----VQAEREAAQSR-RQVEEAERL-KQSAEEQ 2261

Query: 693  REQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER--EKALRLQKEQ 750
             +   + Q   E+ R+E E+    R  AEQ   R+++   AE E  ++  E+ LR QK Q
Sbjct: 2262 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQ 2320

Query: 751  LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQG 810
            +++EL   + + E+    +  L EE ++   EA  A++  +    V+    +      + 
Sbjct: 2321 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS---QVEEELFSVRVQMEEL 2377

Query: 811  HRAPPKINPDNYGMDLNSDDST----DDEAHPRKPI 842
             +   +I  +N  + L   D+T     +EA   K +
Sbjct: 2378 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2413



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 120/513 (23%), Positives = 221/513 (43%), Gaps = 60/513 (11%)

Query: 299  DSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSY 358
            +SQ  R + +  +S   +V A+  +   KQ ++      RL  + AE      R +  + 
Sbjct: 1643 ESQRKRQAEVELAS---RVKAEAEAAREKQRALQALEELRLQAEEAE------RRLRQAE 1693

Query: 359  LERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
            +ER   V+V  +      E   +++  + AE          S       +A      +  
Sbjct: 1694 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR 1750

Query: 419  ASSPETPSAGQQEA---------KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
            A         ++EA         K ++A   R   +   +++S  QA +E  +E   E E
Sbjct: 1751 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---EAE 1807

Query: 470  ELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMD 529
                 R K         + VR        +++ + L   T+  R   +  +     +R+ 
Sbjct: 1808 REARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL-----IRLR 1856

Query: 530  PKCSFVEKERQRLEN----LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR 585
             +    E++RQ LE     L+R+  A   +RQ++E +    L +V+ + E  L    +A 
Sbjct: 1857 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----LAKVRAEMEVLLASKARAE 1912

Query: 586  ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE- 644
            E      E+ K+++E +  +  E  E+A   R   E+AK++   +  EE  AR++ E E 
Sbjct: 1913 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--QLAEEDAARQRAEAER 1970

Query: 645  --ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER 702
              A +L  + +    +   E+  K+KE E ERLR+ AE +    +R +E+  Q + + E 
Sbjct: 1971 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 2030

Query: 703  REQERREQERREQERQ--LAE---QERRREQERLQAERELQEREKA----LRLQKEQLQR 753
            R  + R+    E ERQ  L E   ++RR+ +E + A +   E+  A    L L+  +++ 
Sbjct: 2031 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 2090

Query: 754  ELEEKKKKEEQQRL---AERQLQEEQEKKAKEA 783
              E+  + +EQ  L    +RQL  E+E++ +EA
Sbjct: 2091 NAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2123



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 83/295 (28%), Positives = 143/295 (48%), Gaps = 59/295 (20%)

Query: 540  QRLENLRRKEEAEQLRRQKVEED---KRRRLEEVKLKREERLRKVLQARERVE------- 589
            +RL  LR+  ++E  R++ + ED   +RR++EE  L  +    K    +  +E       
Sbjct: 2030 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 2089

Query: 590  -----QMKEEKKKQIE----QKFAQIDEKTEKAKEERLAEEKAKKKAAAKK----MEEVE 636
                  ++ +++ ++E    ++ A  +E+  +  EER+ +  A ++ AA++    +EEVE
Sbjct: 2090 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2149

Query: 637  ARRKQEEEARRLRWLQQEE------------------EERRHQELLQKKKEEEQ------ 672
              + + EEARRLR   ++E                  EE+ H   +Q+K++E Q      
Sbjct: 2150 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2209

Query: 673  ----ERLRKAAEAKRLAEQREQERREQERRE--QERR---EQERREQERREQERQLAEQE 723
                ++LR  AEA R A +  +E R Q  RE  Q RR   E ER +Q   EQ +  A+ +
Sbjct: 2210 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2269

Query: 724  RRREQERLQAERELQER---EKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEE 775
               E+ R +AE+E   R   E+A   QK+    E+E+ KK  EQ    + Q+++E
Sbjct: 2270 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2324



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 87/289 (30%), Positives = 146/289 (50%), Gaps = 49/289 (16%)

Query: 539  RQRLENLRRKEEAE---QLRRQKVEEDKRRRLEE------VKLKREERLR-------KVL 582
            ++ L+ LR+  EAE   + R+ +  E  R R+EE      ++L+  ER R       + L
Sbjct: 1556 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1615

Query: 583  QAR-ERVEQMKEEKKKQIEQKFAQIDEKTEKAKE---ERLAEEKAKKKAAAKK---MEEV 635
            +AR E  E  K + +++ E+   Q+ +++++ ++   E  +  KA+ +AA +K   ++ +
Sbjct: 1616 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1675

Query: 636  EARRKQEEEARRLRWLQQEEEERRHQ-----ELLQKKKEEEQERLRKAAEAKRLAEQREQ 690
            E  R Q EEA R   L+Q E ER  Q     E  Q+  E E +  ++A+ A++ A+    
Sbjct: 1676 EELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQS-KRASFAEKTAQLERS 1732

Query: 691  ERREQERREQERREQERREQERREQERQLAEQERRREQE------------RLQAERELQ 738
             + E     Q R E ERR Q++ E ER  A +E  RE E            RLQAE   Q
Sbjct: 1733 LQEEHVAVAQLREEAERRAQQQAEAER--AREEAERELERWQLKANEALRLRLQAEEVAQ 1790

Query: 739  EREKA---LRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 784
            ++  A      QKE+ +RE   + K EE Q + +R+L E++ +K ++ A
Sbjct: 1791 QKSLAQAEAEKQKEEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLA 1838



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 126/557 (22%), Positives = 232/557 (41%), Gaps = 107/557 (19%)

Query: 316  QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
            Q L Q+ S++ +       A+RR A++  E    + R    S   R    E  +   S +
Sbjct: 2204 QTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQS---RRQVEEAERLKQSAE 2259

Query: 376  KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTD 435
            ++    A+  AAAE    E          + E A      + A    +   A  ++ K  
Sbjct: 2260 EQAQARAQAQAAAEKLRKEA---------EQEAARRAQAEQAALRQKQAADAEMEKHKKF 2310

Query: 436  QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV------- 488
                 R+  Q  +   + +  + E D +++L DEELQ  +++   +    S+V       
Sbjct: 2311 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2370

Query: 489  ------VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRL 542
                  +  L+  +    R  +L    +  R + +   K         + S   +E  RL
Sbjct: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2430

Query: 543  ENLRRKEEAEQ--LRRQKVEEDKRRRLEEVKLKREERLRKVLQ--ARERVEQMKEEKKKQ 598
              L  ++ A+Q  L  + ++E  +   E  +LK E  L +  +  A+E+  +++E+K++ 
Sbjct: 2431 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2490

Query: 599  IEQKFAQID--EKTEKAKEERLAEEKAKKKAAAKKMEEVE-ARRKQEEEARRLRWLQQEE 655
             +Q   +    ++T +A+ +R  E  A+ +    ++ E+  A+ + EE+A+R R   +E 
Sbjct: 2491 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2550

Query: 656  EERRHQ---------------ELLQKKKEEEQERLRKA-AEAKRLAEQREQERR------ 693
             E+ H+               E+ +++ + + ERLR+A AE +R  E+ +QE +      
Sbjct: 2551 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2610

Query: 694  ------------------------------------EQERREQER-------REQERREQ 710
                                                EQE+ + E+       + Q+ RE+
Sbjct: 2611 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2670

Query: 711  ERREQERQLAEQERRR------EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 764
            ++R+Q++   EQER+R      E  R Q E E   R K   LQ+ + QR  +E+   EE 
Sbjct: 2671 QQRQQQQM--EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN 2728

Query: 765  QRLAER-QLQEEQEKKA 780
            QRL E+ QL EEQ + A
Sbjct: 2729 QRLREQLQLLEEQHRAA 2745



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 78/288 (27%), Positives = 146/288 (50%), Gaps = 32/288 (11%)

Query: 543  ENLRRKEEAEQLRRQKVEEDKRRRLE-EVKLKREERLRKV-LQARERVEQMKEEKKKQIE 600
            E LRR EE E+L  Q+  E++ R  E E  L+++ +L +   QA+ + E+  +E +++++
Sbjct: 1476 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1535

Query: 601  QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 660
            ++  + +E    A++++ + ++  ++       E++A+ +Q E A R R L+ EEE R  
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIR-- 1592

Query: 661  QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720
               + + + E  ER R  AE     E +    R +E   Q+R+ QE  E+ RR    Q+ 
Sbjct: 1593 ---VVRLQLEATERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRR----QVQ 1641

Query: 721  EQERRREQ------ERLQAERE-LQEREKA------LRLQKEQLQREL---EEKKKKEEQ 764
            ++ +R+ Q       R++AE E  +E+++A      LRLQ E+ +R L   E ++ ++ Q
Sbjct: 1642 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1701

Query: 765  QRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHR 812
              L   Q   E E ++K A+ A K   +   +Q       Q+  +  R
Sbjct: 1702 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER 1749



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 78/281 (27%), Positives = 133/281 (47%), Gaps = 27/281 (9%)

Query: 535  VEKERQ---RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQM 591
            VE+ RQ    LE  +R  EAE   ++    +K  +LE    +    + ++ +  ER  Q 
Sbjct: 1694 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753

Query: 592  KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 651
            + E ++  E+   +++    KA E      +A++ A  K + + EA +++EE  R  R  
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813

Query: 652  QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE--QERREQERREQER------- 702
             + EE+   Q  L +++ E+Q +L +    +RLA ++E  + R E E+ EQ+R       
Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1873

Query: 703  ----REQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE- 757
                RE     Q+R+E E +LA+   R E E L A +   E E     +K + + E E  
Sbjct: 1874 ARLQREAAAATQKRQELEAELAKV--RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1931

Query: 758  --KKKKEEQQRL------AERQLQEEQEKKAKEAAGASKAL 790
              ++  EE  RL      A+RQ Q  +E  A++ A A + L
Sbjct: 1932 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1972



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 126/521 (24%), Positives = 216/521 (41%), Gaps = 80/521 (15%)

Query: 319  AQKYSLVAKQESVVRRASRRLAKK-TAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKE 377
            A++  L A++E   R A  R+ K   AEE AA  R      +ERL       KV  E + 
Sbjct: 2107 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL-----KAKV-EEARR 2160

Query: 378  PPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQA 437
              E AE  +A + ++ +          +   A +    +              +    +A
Sbjct: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220

Query: 438  DGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLH 497
            +  R   + A   R   +  +     Q  E E L+    +   +   A      LR    
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--- 2277

Query: 498  TVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQ---- 553
              +  Q       A ++ ++   K+     M+    F E      + LR+K + EQ    
Sbjct: 2278 --EAEQEAARRAQAEQAALRQ--KQAADAEMEKHKKFAE------QTLRQKAQVEQELTT 2327

Query: 554  LRRQKVEEDKRRRLEEVKLKR-EERLRKVLQARERVEQMKEEKKKQIEQKF---AQIDEK 609
            LR Q  E D ++ L + +L+R +    +  + R +VE+     + Q+E+     A+I+ +
Sbjct: 2328 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2387

Query: 610  T------EKAKEERLAEEKAKKKAAAKKMEEVEARRK-QEEEARRLRWLQQEEEERRH-- 660
                   +K   +R  +E+A+K    K++ E  AR     +EA RLR L +E+  ++   
Sbjct: 2388 NRALILRDKDNTQRFLQEEAEKM---KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2444

Query: 661  -QELLQKKKEEEQERLRKAAEAKRLAEQR----EQERREQERREQERRE--------QER 707
             +++L++K +  QE  R  AEA+ L +Q+    EQ RR QE +EQ  ++        Q  
Sbjct: 2445 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2504

Query: 708  REQERREQERQLAEQER-------------RREQE----RLQAER--------ELQEREK 742
             E ER+ Q    AE ER             R E++    R QAE         EL  +EK
Sbjct: 2505 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2564

Query: 743  ALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 783
               +Q  ++QR+  +   +  ++ +AE  L+ E+EK  +EA
Sbjct: 2565 VTLVQTLEIQRQQSDHDAERLREAIAE--LEREKEKLQQEA 2603



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 65/243 (26%), Positives = 118/243 (48%), Gaps = 32/243 (13%)

Query: 578  LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA 637
            + + L+  E  E++ E+++ +  ++ A+++   EK ++  LAE  A+ KA A++  +   
Sbjct: 1474 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ--LAEAHAQAKAQAEREAKELQ 1531

Query: 638  RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 697
            +R QEE  RR       EE     +  ++  +EE ++LR+++EA+  A+ R+ E  E+ R
Sbjct: 1532 QRMQEEVVRR-------EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1584

Query: 698  REQE------RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQ---- 747
               E      R + E  E++R   E +L     R E+   Q +R+ QE  + LR Q    
Sbjct: 1585 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDE 1643

Query: 748  ---KEQLQRELEEKKKKEEQ---------QRLAERQLQEEQEKKAKEAAGASKALNVTVD 795
               K Q + EL  + K E +         Q L E +LQ E+ ++    A   +A  V V 
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1703

Query: 796  VQS 798
            +++
Sbjct: 1704 LET 1706



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 63/289 (21%), Positives = 133/289 (46%), Gaps = 35/289 (12%)

Query: 534  FVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR---KVLQARERVEQ 590
            ++EK +     +R  + AE++ R   E+ K  +     L   E  +   K L+A+   +Q
Sbjct: 1221 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1280

Query: 591  MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA--------RRKQE 642
               +  +   +   ++ E+ ++   ER  E +  ++  A+ +E  +A        +R+ E
Sbjct: 1281 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1340

Query: 643  EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR--EQERREQ 700
            +  R+LR+ + E  +     L   ++ +EQ +    A+++ + EQ  QE+   E+  R  
Sbjct: 1341 QLGRQLRYYR-ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1399

Query: 701  ERREQERREQER-----REQERQLAEQERRRE-------QERLQ--AERELQE------- 739
            E+ E+ +R  ++     ++ E QL   + + E       + ++Q  +E  +QE       
Sbjct: 1400 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1459

Query: 740  REKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788
              +   L  + ++   E  ++ EE++RLAE+Q  EE+E+ A+  A   K
Sbjct: 1460 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1508


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  100 bits (249), Expect = 6e-21
 Identities = 79/271 (29%), Positives = 139/271 (51%), Gaps = 25/271 (9%)

Query: 538  ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERL--------RKVLQARERVE 589
            E    +  + +EEAE+LRRQ  +E +R+R  EV+L    +         ++ LQA E + 
Sbjct: 1461 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1520

Query: 590  QMKEEKKKQIEQ----KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA 645
               EE ++++ Q    +  Q+    E A+    AE ++K+ + A+K  ++E  R  +EE 
Sbjct: 1521 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE--RSLQEEH 1578

Query: 646  RRLRWLQQEEEERRHQELLQKKKEEEQER-----LRKAAEAKRL---AEQREQERREQER 697
              +  L++E E R  Q+   ++  EE ER       KA EA RL   AE+  Q++   + 
Sbjct: 1579 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1638

Query: 698  REQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 757
              ++++E+  RE  RR +  + A ++R   ++ L+ +R+L E     RL  EQ    L  
Sbjct: 1639 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1698

Query: 758  KKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788
            + ++ EQQR   + L+EE  +  +EAA A++
Sbjct: 1699 ETEQGEQQR---QLLEEELARLQREAAAATQ 1726



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 89/313 (28%), Positives = 153/313 (48%), Gaps = 50/313 (15%)

Query: 524  TPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQ 583
            T L+ + + +  EKE +  E LRR  E E  +R+++EE   +   +++ +R  +LRK   
Sbjct: 1824 TRLKTEAEIALKEKEAEN-ERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASD 1881

Query: 584  AR-ERVEQMKEE---KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARR 639
            +  ER + + E+   +++Q+E++   +    EKA   +   E    +  +   + + ++ 
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941

Query: 640  KQEEEARRLRWLQQEEEERRHQ--ELLQKK--KEEEQERLRKAA------------EAKR 683
            + E EA R R L  EEE RR +  E +QK    EEE  R RKAA            EA+R
Sbjct: 1942 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2001

Query: 684  LAEQREQERREQ-----------------------ERREQERREQERREQERREQERQLA 720
            L E+ EQE   Q                       +++EQE ++  ++EQ   +Q R  A
Sbjct: 2002 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2061

Query: 721  EQERR----REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 776
            E  RR     E+ R+QAERE  +  + +  + E+L++  EE+ +   Q + A  +L++E 
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEA 2120

Query: 777  EKKAKEAAGASKA 789
            E++A   A A +A
Sbjct: 2121 EQEAARRAQAEQA 2133



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 105/408 (25%), Positives = 178/408 (43%), Gaps = 70/408 (17%)

Query: 430  QEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK---TPSSPCPAS 486
            Q+    QA+  ++  ++ R  R   +A  +   ++ L ++EL+  R     T      A 
Sbjct: 1631 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1690

Query: 487  KVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLR 546
            + +  LR      ++ + L+    A               R+  + +   ++RQ LE   
Sbjct: 1691 QELIRLRAETEQGEQQRQLLEEELA---------------RLQREAAAATQKRQELEAEL 1735

Query: 547  RKEEAEQ----LRRQKVEEDKRRRLEEVKLKREE---RLRKVLQARERVEQMKEEKKKQI 599
             K  AE       + + EE+ R   E+ K + E    R R++ +   R+  + EE K+Q 
Sbjct: 1736 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ- 1794

Query: 600  EQKFAQIDEKTEKAKEERLAEEK--AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE-- 655
             ++ A+ D   ++A+ ER+  EK  A  +A   K E   A +++E E  RLR L ++E  
Sbjct: 1795 -RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1853

Query: 656  EERRHQELLQKKKEEEQERL---RKAAEA-----KRLAEQREQERREQERR--------- 698
            + RR +E   + K + +ERL   RKA+++     K L E   ++RR+ E           
Sbjct: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1913

Query: 699  --------------------EQERREQERREQERREQERQLAEQERRREQERLQAERELQ 738
                                E   R +E+ E E   Q +  AE+ERRR +   + ++ L 
Sbjct: 1914 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1973

Query: 739  EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE--EQEKKAKEAA 784
              E+A R +K  L+     K K EE +RL ER  QE   Q + A+EAA
Sbjct: 1974 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2021



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 102/372 (27%), Positives = 174/372 (46%), Gaps = 35/372 (9%)

Query: 429  QQEAKTDQADGPREPPQSARR-KRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASK 487
            Q++A  ++ +   E  +  +R  + Y  A+ + + +      +L+P      +SP    K
Sbjct: 1228 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-----ASPAKKPK 1282

Query: 488  VVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK--RNTPLRMDPKCSFVEKERQRLENL 545
            V     +    +Q    L T  S   ++   +IK    T  RM+        E +RL   
Sbjct: 1283 VQSGSES---VIQEYVDLRTHYSELTTLTSQYIKFISETLRRME--------EEERLAEQ 1331

Query: 546  RRKEEAEQLRRQKVEEDKRRRLEEVKLK---REERLRKVLQARERVEQM-KEEKKKQIEQ 601
            +R EE E+L   +   +K+R+L E   +   + ER  K LQ R + E + +EE     +Q
Sbjct: 1332 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1391

Query: 602  KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQ 661
            +   I E+ ++ ++   AE +AK    A++ E  E  R + EE  R+  LQ E  ER+  
Sbjct: 1392 QKRSIQEELQQLRQSSEAEIQAK----ARQAEAAERSRLRIEEEIRVVRLQLEATERQ-- 1445

Query: 662  ELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAE 721
               +   E E + LR  AE     +++ QE  E+ RR+ +   Q +R+ E     R  AE
Sbjct: 1446 ---RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1502

Query: 722  QERRREQER-LQA--ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 778
             E  RE++R LQA  E  LQ  E   RL++ +++R  + +   E  QR AE +LQ ++  
Sbjct: 1503 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1562

Query: 779  KAKEAAGASKAL 790
             A++ A   ++L
Sbjct: 1563 FAEKTAQLERSL 1574



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 78/274 (28%), Positives = 137/274 (50%), Gaps = 26/274 (9%)

Query: 535  VEKERQRLE-----NLRRKEEAEQLRRQKVEEDKRRR-----LEEVKLKREERLRKVLQA 584
            +EK+RQ  E       + + EA++L+++  EE  RR       ++ K   +E L+++ Q+
Sbjct: 1347 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1406

Query: 585  RERVEQMKEEKKKQIEQKFAQIDEKTE------KAKEERLAEEKAKKKAAAKKMEEVEAR 638
             E   Q K  + +  E+   +I+E+        +A E +    + + +A   + EE EA+
Sbjct: 1407 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1466

Query: 639  RKQ-EEEARRLRWLQQEEEERRHQ---ELLQKKKEE-----EQERLRKAAEAKRLAEQRE 689
            ++Q +EEA RLR   Q+E +R+ Q   EL  + K E     E++R  +A E  RL  +  
Sbjct: 1467 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1526

Query: 690  QERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKE 749
            + R  Q   E+ R+ Q   E  +R  E +L  +     ++  Q ER LQE   A+   +E
Sbjct: 1527 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1586

Query: 750  QLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 783
            + +R  +++ + E  +  AER+L E  + KA EA
Sbjct: 1587 EAERRAQQQAEAERAREEAEREL-ERWQLKANEA 1619



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 88/336 (26%), Positives = 165/336 (49%), Gaps = 29/336 (8%)

Query: 526  LRMDPKCSFVEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRL---EEVKLKREERLRK 580
            +R + + +   KE+  LE  R+++ A  E+ RR++ EE  ++ L   EE   +R+  L +
Sbjct: 1929 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1988

Query: 581  VLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRK 640
            V + + +VE+ +  +++  ++   Q+    E A++   AEEKA   A  +K +E++   +
Sbjct: 1989 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2048

Query: 641  QEE--------EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER 692
            QE+        EA   R   +E EE R    +Q ++E  Q R R+  EA+RL +Q  +E+
Sbjct: 2049 QEQSVLDQLRGEAEAARRAAEEAEEAR----VQAEREAAQSR-RQVEEAERL-KQSAEEQ 2102

Query: 693  REQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER--EKALRLQKEQ 750
             +   + Q   E+ R+E E+    R  AEQ   R+++   AE E  ++  E+ LR QK Q
Sbjct: 2103 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQ 2161

Query: 751  LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQG 810
            +++EL   + + E+    +  L EE ++   EA  A++  +    V+    +      + 
Sbjct: 2162 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS---QVEEELFSVRVQMEEL 2218

Query: 811  HRAPPKINPDNYGMDLNSDDST----DDEAHPRKPI 842
             +   +I  +N  + L   D+T     +EA   K +
Sbjct: 2219 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2254



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 120/513 (23%), Positives = 221/513 (43%), Gaps = 60/513 (11%)

Query: 299  DSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSY 358
            +SQ  R + +  +S   +V A+  +   KQ ++      RL  + AE      R +  + 
Sbjct: 1484 ESQRKRQAEVELAS---RVKAEAEAAREKQRALQALEELRLQAEEAE------RRLRQAE 1534

Query: 359  LERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
            +ER   V+V  +      E   +++  + AE          S       +A      +  
Sbjct: 1535 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR 1591

Query: 419  ASSPETPSAGQQEA---------KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
            A         ++EA         K ++A   R   +   +++S  QA +E  +E   E E
Sbjct: 1592 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---EAE 1648

Query: 470  ELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMD 529
                 R K         + VR        +++ + L   T+  R   +  +     +R+ 
Sbjct: 1649 REARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL-----IRLR 1697

Query: 530  PKCSFVEKERQRLEN----LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR 585
             +    E++RQ LE     L+R+  A   +RQ++E +    L +V+ + E  L    +A 
Sbjct: 1698 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----LAKVRAEMEVLLASKARAE 1753

Query: 586  ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE- 644
            E      E+ K+++E +  +  E  E+A   R   E+AK++   +  EE  AR++ E E 
Sbjct: 1754 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--QLAEEDAARQRAEAER 1811

Query: 645  --ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER 702
              A +L  + +    +   E+  K+KE E ERLR+ AE +    +R +E+  Q + + E 
Sbjct: 1812 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1871

Query: 703  REQERREQERREQERQ--LAE---QERRREQERLQAERELQEREKA----LRLQKEQLQR 753
            R  + R+    E ERQ  L E   ++RR+ +E + A +   E+  A    L L+  +++ 
Sbjct: 1872 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1931

Query: 754  ELEEKKKKEEQQRL---AERQLQEEQEKKAKEA 783
              E+  + +EQ  L    +RQL  E+E++ +EA
Sbjct: 1932 NAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1964



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 83/295 (28%), Positives = 143/295 (48%), Gaps = 59/295 (20%)

Query: 540  QRLENLRRKEEAEQLRRQKVEED---KRRRLEEVKLKREERLRKVLQARERVE------- 589
            +RL  LR+  ++E  R++ + ED   +RR++EE  L  +    K    +  +E       
Sbjct: 1871 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1930

Query: 590  -----QMKEEKKKQIE----QKFAQIDEKTEKAKEERLAEEKAKKKAAAKK----MEEVE 636
                  ++ +++ ++E    ++ A  +E+  +  EER+ +  A ++ AA++    +EEVE
Sbjct: 1931 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 1990

Query: 637  ARRKQEEEARRLRWLQQEE------------------EERRHQELLQKKKEEEQ------ 672
              + + EEARRLR   ++E                  EE+ H   +Q+K++E Q      
Sbjct: 1991 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2050

Query: 673  ----ERLRKAAEAKRLAEQREQERREQERRE--QERR---EQERREQERREQERQLAEQE 723
                ++LR  AEA R A +  +E R Q  RE  Q RR   E ER +Q   EQ +  A+ +
Sbjct: 2051 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2110

Query: 724  RRREQERLQAERELQER---EKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEE 775
               E+ R +AE+E   R   E+A   QK+    E+E+ KK  EQ    + Q+++E
Sbjct: 2111 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2165



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 87/289 (30%), Positives = 146/289 (50%), Gaps = 49/289 (16%)

Query: 539  RQRLENLRRKEEAE---QLRRQKVEEDKRRRLEE------VKLKREERLR-------KVL 582
            ++ L+ LR+  EAE   + R+ +  E  R R+EE      ++L+  ER R       + L
Sbjct: 1397 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1456

Query: 583  QAR-ERVEQMKEEKKKQIEQKFAQIDEKTEKAKE---ERLAEEKAKKKAAAKK---MEEV 635
            +AR E  E  K + +++ E+   Q+ +++++ ++   E  +  KA+ +AA +K   ++ +
Sbjct: 1457 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1516

Query: 636  EARRKQEEEARRLRWLQQEEEERRHQ-----ELLQKKKEEEQERLRKAAEAKRLAEQREQ 690
            E  R Q EEA R   L+Q E ER  Q     E  Q+  E E +  ++A+ A++ A+    
Sbjct: 1517 EELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQS-KRASFAEKTAQLERS 1573

Query: 691  ERREQERREQERREQERREQERREQERQLAEQERRREQE------------RLQAERELQ 738
             + E     Q R E ERR Q++ E ER  A +E  RE E            RLQAE   Q
Sbjct: 1574 LQEEHVAVAQLREEAERRAQQQAEAER--AREEAERELERWQLKANEALRLRLQAEEVAQ 1631

Query: 739  EREKA---LRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 784
            ++  A      QKE+ +RE   + K EE Q + +R+L E++ +K ++ A
Sbjct: 1632 QKSLAQAEAEKQKEEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLA 1679



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 126/557 (22%), Positives = 232/557 (41%), Gaps = 107/557 (19%)

Query: 316  QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
            Q L Q+ S++ +       A+RR A++  E    + R    S   R    E  +   S +
Sbjct: 2045 QTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQS---RRQVEEAERLKQSAE 2100

Query: 376  KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTD 435
            ++    A+  AAAE    E          + E A      + A    +   A  ++ K  
Sbjct: 2101 EQAQARAQAQAAAEKLRKEA---------EQEAARRAQAEQAALRQKQAADAEMEKHKKF 2151

Query: 436  QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKV------- 488
                 R+  Q  +   + +  + E D +++L DEELQ  +++   +    S+V       
Sbjct: 2152 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2211

Query: 489  ------VRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRL 542
                  +  L+  +    R  +L    +  R + +   K         + S   +E  RL
Sbjct: 2212 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2271

Query: 543  ENLRRKEEAEQ--LRRQKVEEDKRRRLEEVKLKREERLRKVLQ--ARERVEQMKEEKKKQ 598
              L  ++ A+Q  L  + ++E  +   E  +LK E  L +  +  A+E+  +++E+K++ 
Sbjct: 2272 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2331

Query: 599  IEQKFAQID--EKTEKAKEERLAEEKAKKKAAAKKMEEVE-ARRKQEEEARRLRWLQQEE 655
             +Q   +    ++T +A+ +R  E  A+ +    ++ E+  A+ + EE+A+R R   +E 
Sbjct: 2332 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2391

Query: 656  EERRHQ---------------ELLQKKKEEEQERLRKA-AEAKRLAEQREQERR------ 693
             E+ H+               E+ +++ + + ERLR+A AE +R  E+ +QE +      
Sbjct: 2392 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2451

Query: 694  ------------------------------------EQERREQER-------REQERREQ 710
                                                EQE+ + E+       + Q+ RE+
Sbjct: 2452 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2511

Query: 711  ERREQERQLAEQERRR------EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 764
            ++R+Q++   EQER+R      E  R Q E E   R K   LQ+ + QR  +E+   EE 
Sbjct: 2512 QQRQQQQM--EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN 2569

Query: 765  QRLAER-QLQEEQEKKA 780
            QRL E+ QL EEQ + A
Sbjct: 2570 QRLREQLQLLEEQHRAA 2586



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 78/288 (27%), Positives = 146/288 (50%), Gaps = 32/288 (11%)

Query: 543  ENLRRKEEAEQLRRQKVEEDKRRRLE-EVKLKREERLRKV-LQARERVEQMKEEKKKQIE 600
            E LRR EE E+L  Q+  E++ R  E E  L+++ +L +   QA+ + E+  +E +++++
Sbjct: 1317 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1376

Query: 601  QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 660
            ++  + +E    A++++ + ++  ++       E++A+ +Q E A R R L+ EEE R  
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIR-- 1433

Query: 661  QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720
               + + + E  ER R  AE     E +    R +E   Q+R+ QE  E+ RR    Q+ 
Sbjct: 1434 ---VVRLQLEATERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRR----QVQ 1482

Query: 721  EQERRREQ------ERLQAERE-LQEREKA------LRLQKEQLQREL---EEKKKKEEQ 764
            ++ +R+ Q       R++AE E  +E+++A      LRLQ E+ +R L   E ++ ++ Q
Sbjct: 1483 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1542

Query: 765  QRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHR 812
              L   Q   E E ++K A+ A K   +   +Q       Q+  +  R
Sbjct: 1543 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER 1590



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 78/281 (27%), Positives = 133/281 (47%), Gaps = 27/281 (9%)

Query: 535  VEKERQ---RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQM 591
            VE+ RQ    LE  +R  EAE   ++    +K  +LE    +    + ++ +  ER  Q 
Sbjct: 1535 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594

Query: 592  KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 651
            + E ++  E+   +++    KA E      +A++ A  K + + EA +++EE  R  R  
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654

Query: 652  QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE--QERREQERREQER------- 702
             + EE+   Q  L +++ E+Q +L +    +RLA ++E  + R E E+ EQ+R       
Sbjct: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1714

Query: 703  ----REQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE- 757
                RE     Q+R+E E +LA+   R E E L A +   E E     +K + + E E  
Sbjct: 1715 ARLQREAAAATQKRQELEAELAKV--RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1772

Query: 758  --KKKKEEQQRL------AERQLQEEQEKKAKEAAGASKAL 790
              ++  EE  RL      A+RQ Q  +E  A++ A A + L
Sbjct: 1773 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1813



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 126/521 (24%), Positives = 216/521 (41%), Gaps = 80/521 (15%)

Query: 319  AQKYSLVAKQESVVRRASRRLAKK-TAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKE 377
            A++  L A++E   R A  R+ K   AEE AA  R      +ERL       KV  E + 
Sbjct: 1948 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL-----KAKV-EEARR 2001

Query: 378  PPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQA 437
              E AE  +A + ++ +          +   A +    +              +    +A
Sbjct: 2002 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2061

Query: 438  DGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLH 497
            +  R   + A   R   +  +     Q  E E L+    +   +   A      LR    
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--- 2118

Query: 498  TVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQ---- 553
              +  Q       A ++ ++   K+     M+    F E      + LR+K + EQ    
Sbjct: 2119 --EAEQEAARRAQAEQAALRQ--KQAADAEMEKHKKFAE------QTLRQKAQVEQELTT 2168

Query: 554  LRRQKVEEDKRRRLEEVKLKR-EERLRKVLQARERVEQMKEEKKKQIEQKF---AQIDEK 609
            LR Q  E D ++ L + +L+R +    +  + R +VE+     + Q+E+     A+I+ +
Sbjct: 2169 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2228

Query: 610  T------EKAKEERLAEEKAKKKAAAKKMEEVEARRK-QEEEARRLRWLQQEEEERRH-- 660
                   +K   +R  +E+A+K    K++ E  AR     +EA RLR L +E+  ++   
Sbjct: 2229 NRALILRDKDNTQRFLQEEAEKM---KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2285

Query: 661  -QELLQKKKEEEQERLRKAAEAKRLAEQR----EQERREQERREQERRE--------QER 707
             +++L++K +  QE  R  AEA+ L +Q+    EQ RR QE +EQ  ++        Q  
Sbjct: 2286 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2345

Query: 708  REQERREQERQLAEQER-------------RREQE----RLQAER--------ELQEREK 742
             E ER+ Q    AE ER             R E++    R QAE         EL  +EK
Sbjct: 2346 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2405

Query: 743  ALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 783
               +Q  ++QR+  +   +  ++ +AE  L+ E+EK  +EA
Sbjct: 2406 VTLVQTLEIQRQQSDHDAERLREAIAE--LEREKEKLQQEA 2444



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 65/243 (26%), Positives = 118/243 (48%), Gaps = 32/243 (13%)

Query: 578  LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA 637
            + + L+  E  E++ E+++ +  ++ A+++   EK ++  LAE  A+ KA A++  +   
Sbjct: 1315 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ--LAEAHAQAKAQAEREAKELQ 1372

Query: 638  RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 697
            +R QEE  RR       EE     +  ++  +EE ++LR+++EA+  A+ R+ E  E+ R
Sbjct: 1373 QRMQEEVVRR-------EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1425

Query: 698  REQE------RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQ---- 747
               E      R + E  E++R   E +L     R E+   Q +R+ QE  + LR Q    
Sbjct: 1426 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDE 1484

Query: 748  ---KEQLQRELEEKKKKEEQ---------QRLAERQLQEEQEKKAKEAAGASKALNVTVD 795
               K Q + EL  + K E +         Q L E +LQ E+ ++    A   +A  V V 
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1544

Query: 796  VQS 798
            +++
Sbjct: 1545 LET 1547



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 63/289 (21%), Positives = 133/289 (46%), Gaps = 35/289 (12%)

Query: 534  FVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR---KVLQARERVEQ 590
            ++EK +     +R  + AE++ R   E+ K  +     L   E  +   K L+A+   +Q
Sbjct: 1062 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1121

Query: 591  MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA--------RRKQE 642
               +  +   +   ++ E+ ++   ER  E +  ++  A+ +E  +A        +R+ E
Sbjct: 1122 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1181

Query: 643  EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR--EQERREQ 700
            +  R+LR+ + E  +     L   ++ +EQ +    A+++ + EQ  QE+   E+  R  
Sbjct: 1182 QLGRQLRYYR-ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1240

Query: 701  ERREQERREQER-----REQERQLAEQERRRE-------QERLQ--AERELQE------- 739
            E+ E+ +R  ++     ++ E QL   + + E       + ++Q  +E  +QE       
Sbjct: 1241 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1300

Query: 740  REKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788
              +   L  + ++   E  ++ EE++RLAE+Q  EE+E+ A+  A   K
Sbjct: 1301 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1349


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.124    0.339 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,388,556
Number of Sequences: 37866
Number of extensions: 2382885
Number of successful extensions: 123136
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1677
Number of HSP's successfully gapped in prelim test: 1713
Number of HSP's that attempted gapping in prelim test: 18784
Number of HSP's gapped (non-prelim): 30105
length of query: 918
length of database: 18,247,518
effective HSP length: 111
effective length of query: 807
effective length of database: 14,044,392
effective search space: 11333824344
effective search space used: 11333824344
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.