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Search of human proteins with 10092619
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10092619 nuclear factor of kappa light polypeptide gene
enhancer in B-cells inhibitor, alpha [Homo sapiens]
(317 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10092619 nuclear factor of kappa light polypeptide gene enhan... 649 0.0
gi|71274109 nuclear factor of kappa light polypeptide gene enhan... 141 9e-34
gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens] 139 4e-33
gi|21361135 nuclear factor of kappa light polypeptide gene enhan... 119 3e-27
gi|117320531 nuclear factor of kappa light polypeptide gene enha... 114 9e-26
gi|117320540 nuclear factor of kappa light polypeptide gene enha... 114 9e-26
gi|117320527 nuclear factor of kappa light polypeptide gene enha... 114 9e-26
gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens] 110 2e-24
gi|48928017 nuclear factor of kappa light polypeptide gene enhan... 98 1e-20
gi|30348954 mindbomb homolog 1 [Homo sapiens] 90 2e-18
gi|53832024 nuclear factor of kappa light polypeptide gene enhan... 89 4e-18
gi|13899229 nuclear factor of kappa light polypeptide gene enhan... 89 4e-18
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 84 2e-16
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 84 2e-16
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 84 2e-16
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 84 2e-16
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 84 2e-16
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 81 1e-15
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 79 5e-15
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 79 5e-15
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 79 5e-15
gi|140161500 ankyrin repeat and sterile alpha motif domain conta... 79 7e-15
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 79 7e-15
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 76 3e-14
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 76 3e-14
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 76 3e-14
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 76 3e-14
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 76 3e-14
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 76 3e-14
gi|38327522 cardiac ankyrin repeat protein [Homo sapiens] 76 3e-14
>gi|10092619 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, alpha [Homo sapiens]
Length = 317
Score = 649 bits (1673), Expect = 0.0
Identities = 317/317 (100%), Positives = 317/317 (100%)
Query: 1 MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVP 60
MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVP
Sbjct: 1 MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVP 60
Query: 61 RGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVI 120
RGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVI
Sbjct: 61 RGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVI 120
Query: 121 TNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATN 180
TNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATN
Sbjct: 121 TNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATN 180
Query: 181 YNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCG 240
YNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCG
Sbjct: 181 YNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCG 240
Query: 241 ADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTE 300
ADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTE
Sbjct: 241 ADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTE 300
Query: 301 DELPYDDCVFGGQRLTL 317
DELPYDDCVFGGQRLTL
Sbjct: 301 DELPYDDCVFGGQRLTL 317
>gi|71274109 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, epsilon [Homo sapiens]
Length = 500
Score = 141 bits (355), Expect = 9e-34
Identities = 94/250 (37%), Positives = 138/250 (55%), Gaps = 12/250 (4%)
Query: 70 LTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEA 129
++EDGD+ +HLA+IHE A+ + + + ++ L+ QNNL QT LHLAV +QP A
Sbjct: 255 ISEDGDTLVHLAVIHEAPAVLLCCLALLPQEV--LDIQNNLYQTALHLAVHLDQPGAVRA 312
Query: 130 LLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL---HSI-LKATNYNGHT 185
L+ G L+D G+T LH+AC++ LA L + P HS+ L+ N+ G
Sbjct: 313 LVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLA 372
Query: 186 CLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNR 245
CLH+A++ ++ELL+ GAD++ QE +G+TALHLAV+ Q LV LL+ GA V+
Sbjct: 373 CLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDA 432
Query: 246 VTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTEDELPY 305
G +P L GR I L + ++L L EDE T + TE + LP+
Sbjct: 433 RMLNGCTPLHLAAGRGLMGISSTLCKAGADSL--LRNVEDE----TPQDLTEESLVLLPF 486
Query: 306 DDCVFGGQRL 315
DD G+ L
Sbjct: 487 DDLKISGKLL 496
>gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]
Length = 969
Score = 139 bits (349), Expect = 4e-33
Identities = 95/234 (40%), Positives = 127/234 (54%), Gaps = 10/234 (4%)
Query: 72 EDGDSFLHLAIIHEEKALTMEVIRQVKGDLA--FLNFQNNLQQTPLHLAVITNQPEIAEA 129
E+GDS LHLAIIH L +++ G ++ +N +N+L QTPLHLAVIT Q ++ E
Sbjct: 542 ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED 601
Query: 130 LLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHL 189
LL AG D L D GN+ LHLA ++G + +L + L L N +G +HL
Sbjct: 602 LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL---LDHPNGDGLNAIHL 658
Query: 190 ASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVS-LLLKCGADVNRVTY 248
A + L + LLV+ GADVNAQE +GRTALHLAV+ N L LLL+ A V+ TY
Sbjct: 659 AMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTY 718
Query: 249 QGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTEDE 302
G +P + GR STR+ L + L E YD + + EDE
Sbjct: 719 DGTTPLHIAAGRGSTRLAALLKAAGADPL----VENFEPLYDLDDSWENAGEDE 768
>gi|21361135 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, beta isoform a [Homo sapiens]
Length = 356
Score = 119 bits (299), Expect = 3e-27
Identities = 94/287 (32%), Positives = 128/287 (44%), Gaps = 47/287 (16%)
Query: 70 LTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEA 129
+TEDGD+ LHLA+IH+ + ++ + +++ QN+L QT LHLA I + E
Sbjct: 54 VTEDGDTALHLAVIHQHEPF-LDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEK 112
Query: 130 LLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCT-----------------TPHL 172
L AG + + RG+T LHLAC G A L Q TP
Sbjct: 113 LYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDT 172
Query: 173 HSI------------------------LKATNYNGHTCLHLASIHGYLGIVELLVSLGAD 208
+ L+A NY GHT LH+A IH + +V LL GAD
Sbjct: 173 NHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGAD 232
Query: 209 VNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQ 268
++ EP GR+ LHLAV+ Q D++ LLL+ GA+ Y G +P G R
Sbjct: 233 LDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL----GSAMLRPNPI 288
Query: 269 LGQLTLENLQMLPESEDEESYDTESEFTEFTEDE-LPYDDCVFGGQR 314
L +L + PE EDE+S S + DE YDD V R
Sbjct: 289 LARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGDEYDDIVVHSSR 335
Score = 50.1 bits (118), Expect = 3e-06
Identities = 32/95 (33%), Positives = 50/95 (52%), Gaps = 6/95 (6%)
Query: 57 QEVPRGSEPWKQQLTED---GDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQT 113
+E E WK QL + G + LH+A+IH++ + + ++R DL + ++
Sbjct: 187 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEM-VRLLRDAGADLD--KPEPTCGRS 243
Query: 114 PLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPL 148
PLHLAV ++ E LL AG +P R + G TPL
Sbjct: 244 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 278
>gi|117320531 nuclear factor of kappa light polypeptide gene
enhancer in B-cells 2 isoform a [Homo sapiens]
Length = 900
Score = 114 bits (286), Expect = 9e-26
Identities = 92/252 (36%), Positives = 132/252 (52%), Gaps = 21/252 (8%)
Query: 72 EDGDSFLHLAIIHEEKALTMEVIRQVKG--DLAFLNFQNNLQQTPLHLAVITNQPEIAEA 129
E+GD+ LHLAIIH + ++ +++ + DL +N N+L QTPLHLAVIT Q +
Sbjct: 486 ENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSF 545
Query: 130 LLGAGCDPELRDFRGNTPLHLACEQGCLAS--VGVLTQSCTTPHLHSILKATNYNGHTCL 187
LL G DP L D G++ +HLA G A + L QS P + +L ++ G +
Sbjct: 546 LLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQS-GAPAVPQLLHMPDFEGLYPV 604
Query: 188 HLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVS-LLLKCGADVNRV 246
HLA ++LLV GA+V A E GRTALHLA +++ LV+ L+ K A+VN
Sbjct: 605 HLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNAR 664
Query: 247 TYQGYSPYQLT--WGRPS-TRIQQQLG-QLTLENLQML-----PESEDEES------YDT 291
T+ G +P L G P+ TR+ + G + EN + L P + D +S DT
Sbjct: 665 TFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDT 724
Query: 292 ESEFTEFTEDEL 303
S F T +L
Sbjct: 725 RSSFRGHTPLDL 736
Score = 44.3 bits (103), Expect = 1e-04
Identities = 40/120 (33%), Positives = 54/120 (45%), Gaps = 10/120 (8%)
Query: 175 ILKATNYNGHTCLHLASIHGYLGIVELLVSL---GADVNAQEPCN--GRTALHLAVDLQN 229
+L A + NG T LHLA IHG ++E +V + D+ N +T LHLAV
Sbjct: 480 LLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQ 539
Query: 230 PDLVSLLLKCGADVNRVTYQGYSPYQLTW----GRPS-TRIQQQLGQLTLENLQMLPESE 284
+VS LL+ GAD + G S L G P R Q G + L +P+ E
Sbjct: 540 TSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFE 599
>gi|117320540 nuclear factor of kappa light polypeptide gene
enhancer in B-cells 2 isoform b [Homo sapiens]
Length = 899
Score = 114 bits (286), Expect = 9e-26
Identities = 92/252 (36%), Positives = 132/252 (52%), Gaps = 21/252 (8%)
Query: 72 EDGDSFLHLAIIHEEKALTMEVIRQVKG--DLAFLNFQNNLQQTPLHLAVITNQPEIAEA 129
E+GD+ LHLAIIH + ++ +++ + DL +N N+L QTPLHLAVIT Q +
Sbjct: 486 ENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSF 545
Query: 130 LLGAGCDPELRDFRGNTPLHLACEQGCLAS--VGVLTQSCTTPHLHSILKATNYNGHTCL 187
LL G DP L D G++ +HLA G A + L QS P + +L ++ G +
Sbjct: 546 LLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQS-GAPAVPQLLHMPDFEGLYPV 604
Query: 188 HLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVS-LLLKCGADVNRV 246
HLA ++LLV GA+V A E GRTALHLA +++ LV+ L+ K A+VN
Sbjct: 605 HLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNAR 664
Query: 247 TYQGYSPYQLT--WGRPS-TRIQQQLG-QLTLENLQML-----PESEDEES------YDT 291
T+ G +P L G P+ TR+ + G + EN + L P + D +S DT
Sbjct: 665 TFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDT 724
Query: 292 ESEFTEFTEDEL 303
S F T +L
Sbjct: 725 RSSFRGHTPLDL 736
Score = 44.3 bits (103), Expect = 1e-04
Identities = 40/120 (33%), Positives = 54/120 (45%), Gaps = 10/120 (8%)
Query: 175 ILKATNYNGHTCLHLASIHGYLGIVELLVSL---GADVNAQEPCN--GRTALHLAVDLQN 229
+L A + NG T LHLA IHG ++E +V + D+ N +T LHLAV
Sbjct: 480 LLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQ 539
Query: 230 PDLVSLLLKCGADVNRVTYQGYSPYQLTW----GRPS-TRIQQQLGQLTLENLQMLPESE 284
+VS LL+ GAD + G S L G P R Q G + L +P+ E
Sbjct: 540 TSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFE 599
>gi|117320527 nuclear factor of kappa light polypeptide gene
enhancer in B-cells 2 isoform b [Homo sapiens]
Length = 899
Score = 114 bits (286), Expect = 9e-26
Identities = 92/252 (36%), Positives = 132/252 (52%), Gaps = 21/252 (8%)
Query: 72 EDGDSFLHLAIIHEEKALTMEVIRQVKG--DLAFLNFQNNLQQTPLHLAVITNQPEIAEA 129
E+GD+ LHLAIIH + ++ +++ + DL +N N+L QTPLHLAVIT Q +
Sbjct: 486 ENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSF 545
Query: 130 LLGAGCDPELRDFRGNTPLHLACEQGCLAS--VGVLTQSCTTPHLHSILKATNYNGHTCL 187
LL G DP L D G++ +HLA G A + L QS P + +L ++ G +
Sbjct: 546 LLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQS-GAPAVPQLLHMPDFEGLYPV 604
Query: 188 HLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVS-LLLKCGADVNRV 246
HLA ++LLV GA+V A E GRTALHLA +++ LV+ L+ K A+VN
Sbjct: 605 HLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNAR 664
Query: 247 TYQGYSPYQLT--WGRPS-TRIQQQLG-QLTLENLQML-----PESEDEES------YDT 291
T+ G +P L G P+ TR+ + G + EN + L P + D +S DT
Sbjct: 665 TFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDT 724
Query: 292 ESEFTEFTEDEL 303
S F T +L
Sbjct: 725 RSSFRGHTPLDL 736
Score = 44.3 bits (103), Expect = 1e-04
Identities = 40/120 (33%), Positives = 54/120 (45%), Gaps = 10/120 (8%)
Query: 175 ILKATNYNGHTCLHLASIHGYLGIVELLVSL---GADVNAQEPCN--GRTALHLAVDLQN 229
+L A + NG T LHLA IHG ++E +V + D+ N +T LHLAV
Sbjct: 480 LLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQ 539
Query: 230 PDLVSLLLKCGADVNRVTYQGYSPYQLTW----GRPS-TRIQQQLGQLTLENLQMLPESE 284
+VS LL+ GAD + G S L G P R Q G + L +P+ E
Sbjct: 540 TSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFE 599
>gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens]
Length = 454
Score = 110 bits (275), Expect = 2e-24
Identities = 71/189 (37%), Positives = 98/189 (51%), Gaps = 2/189 (1%)
Query: 72 EDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALL 131
EDGD+ LH+A++ ++ + L+ NNL+QTPLHLAVIT P + L+
Sbjct: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
Query: 132 GAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLAS 191
AG P D G T HLACE + L S L L+A NY+G T LH+A
Sbjct: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLD--LEARNYDGLTALHVAV 250
Query: 192 IHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGY 251
V+LL+ GAD++A + +GR+ L AV+ + +V LLL+ GA+VN Y G
Sbjct: 251 NTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGS 310
Query: 252 SPYQLTWGR 260
S GR
Sbjct: 311 SALHSASGR 319
Score = 43.9 bits (102), Expect = 2e-04
Identities = 40/114 (35%), Positives = 53/114 (46%), Gaps = 7/114 (6%)
Query: 141 DFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVE 200
D G+TPLH+A QG L +V L L N T LHLA I +V
Sbjct: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRE--LDIYNNLRQTPLHLAVITTLPSVVR 189
Query: 201 LLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGA----DVNRVTYQG 250
LLV+ GA A + +G+TA HLA + ++P + LL A D+ Y G
Sbjct: 190 LLVTAGASPMALDR-HGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDG 242
>gi|48928017 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, beta isoform b [Homo sapiens]
Length = 306
Score = 97.8 bits (242), Expect = 1e-20
Identities = 78/241 (32%), Positives = 104/241 (43%), Gaps = 45/241 (18%)
Query: 103 FLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGV 162
+++ QN+L QT LHLA I + E L AG + + RG+T LHLAC G A
Sbjct: 54 YMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARA 113
Query: 163 LTQSCT-----------------TPHLHSI------------------------LKATNY 181
L Q TP + L+A NY
Sbjct: 114 LLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENY 173
Query: 182 NGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGA 241
GHT LH+A IH + +V LL GAD++ EP GR+ LHLAV+ Q D++ LLL+ GA
Sbjct: 174 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 233
Query: 242 DVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTED 301
+ Y G +P G R L +L + PE EDE+S S + D
Sbjct: 234 NPAARMYGGRTPL----GSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGD 289
Query: 302 E 302
E
Sbjct: 290 E 290
Score = 50.1 bits (118), Expect = 3e-06
Identities = 32/95 (33%), Positives = 50/95 (52%), Gaps = 6/95 (6%)
Query: 57 QEVPRGSEPWKQQLTED---GDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQT 113
+E E WK QL + G + LH+A+IH++ + + ++R DL + ++
Sbjct: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEM-VRLLRDAGADLD--KPEPTCGRS 211
Query: 114 PLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPL 148
PLHLAV ++ E LL AG +P R + G TPL
Sbjct: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 246
>gi|30348954 mindbomb homolog 1 [Homo sapiens]
Length = 1006
Score = 90.1 bits (222), Expect = 2e-18
Identities = 76/254 (29%), Positives = 120/254 (47%), Gaps = 47/254 (18%)
Query: 72 EDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALL 131
+DGD +H A +E A+ +EV+ + DL N +N +QTPLH+AV ++ + LL
Sbjct: 495 KDGDRAVHHAAFGDEGAV-IEVLHRGSADL---NARNKRRQTPLHIAVNKGHLQVVKTLL 550
Query: 132 GAGCDPELRDFRGNTPLHLACEQ------GCLASVGV---LTQSCTTPHLHS-------- 174
GC P L+D G+TPLH A + L G +T + LH
Sbjct: 551 DFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPS 610
Query: 175 -------------ILKATNYNGHTCLHLASIHGYLGIVELLVSLG-ADVNAQEPCNGRTA 220
I+ +G+T LHLA+++ ++ + ELLV G A+++ Q N +TA
Sbjct: 611 AMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQN-VNQQTA 669
Query: 221 LHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQML 280
LHLAV+ Q+ +V LL++ GA ++ G +P + + L TL L+ L
Sbjct: 670 LHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTP-----------LHEALRHHTLSQLRQL 718
Query: 281 PESEDEESYDTESE 294
+ +D D E
Sbjct: 719 QDMQDVGKVDAAWE 732
Score = 55.1 bits (131), Expect = 8e-08
Identities = 54/197 (27%), Positives = 89/197 (45%), Gaps = 25/197 (12%)
Query: 52 IRLEPQEVPRGSEPW-KQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNL 110
+R+ ++PR PW + +DG + LHLA ++ + ++ Q +L + QN
Sbjct: 612 MRVLLSKLPR---PWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANL---DIQNVN 665
Query: 111 QQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVL------- 163
QQT LHLAV +I L+ AG +++D G+TPLH A L+ + L
Sbjct: 666 QQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVG 725
Query: 164 -TQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALH 222
+ P ++++ G ASI + L + GAD++ + G++ L
Sbjct: 726 KVDAAWEPSKNTLIMGLGTQGAEKKSAASIACF------LAANGADLSIRNK-KGQSPLD 778
Query: 223 LAVDLQNPDLVSLLLKC 239
L D P+L L KC
Sbjct: 779 LCPD---PNLCKALAKC 792
Score = 30.4 bits (67), Expect = 2.2
Identities = 21/78 (26%), Positives = 40/78 (51%), Gaps = 1/78 (1%)
Query: 176 LKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSL 235
++A + +G +H A+ ++E+L AD+NA+ +T LH+AV+ + +V
Sbjct: 490 VEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNK-RRQTPLHIAVNKGHLQVVKT 548
Query: 236 LLKCGADVNRVTYQGYSP 253
LL G + +G +P
Sbjct: 549 LLDFGCHPSLQDSEGDTP 566
Score = 30.0 bits (66), Expect = 2.8
Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 8/93 (8%)
Query: 157 LASVGVLTQSCTTPHLHSILKA---TNYNGHTCLHL--ASIHGYLGIVE-LLVSLGADVN 210
+AS G + + L +LK T +G L A+ +G + VE LL DVN
Sbjct: 400 VASAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVN 459
Query: 211 AQEPCNGRTALHLAVDLQNPDLVSLLLKCGADV 243
Q C G TA+ A + D++ LLLK DV
Sbjct: 460 GQ--CAGHTAMQAASQNGHVDILKLLLKQNVDV 490
>gi|53832024 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, zeta isoform b [Homo sapiens]
Length = 618
Score = 89.4 bits (220), Expect = 4e-18
Identities = 76/283 (26%), Positives = 131/283 (46%), Gaps = 39/283 (13%)
Query: 44 QMVKELQEIRLEPQEVPRGSEPWKQQLTED--GDSFLHLAIIHEEKALTMEVIRQVKGDL 101
Q+ K L + ++E +E + Q L++D GD+FLH+A+ +AL+ + R++ L
Sbjct: 312 QLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNA-L 370
Query: 102 AFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVG 161
L+ + + Q+ +AV NQ I + L+ G D G TPLH+ E+G +
Sbjct: 371 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQ 430
Query: 162 VLTQSCTTPHLHSILKATNYNGHTCLHLASI---------------------------HG 194
+ + + L+ATNY+G T LH A I
Sbjct: 431 AIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKS 490
Query: 195 YLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLK---CGADVNRVTYQGY 251
+ ++ L+ +GA V A++ +GRTALHLA + N +L+ L L+ C + VN Y G
Sbjct: 491 LVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGN 550
Query: 252 SPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESE 294
+ + + +Q +L QL L ++ + D + + E+E
Sbjct: 551 TALHV-----AASLQYRLTQLDAVRL-LMRKGADPSTRNLENE 587
Score = 30.8 bits (68), Expect = 1.7
Identities = 24/86 (27%), Positives = 39/86 (45%), Gaps = 11/86 (12%)
Query: 72 EDGDSFLHLAIIHEEKALTMEVIR---QVKGDLAFLNFQNNLQQTPLHLAVITN----QP 124
+ G + LHLA + +E+IR ++ L+F+N + T LH+A Q
Sbjct: 511 KSGRTALHLAA----EEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQL 566
Query: 125 EIAEALLGAGCDPELRDFRGNTPLHL 150
+ L+ G DP R+ P+HL
Sbjct: 567 DAVRLLMRKGADPSTRNLENEQPVHL 592
>gi|13899229 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, zeta isoform a [Homo sapiens]
Length = 718
Score = 89.4 bits (220), Expect = 4e-18
Identities = 76/283 (26%), Positives = 131/283 (46%), Gaps = 39/283 (13%)
Query: 44 QMVKELQEIRLEPQEVPRGSEPWKQQLTED--GDSFLHLAIIHEEKALTMEVIRQVKGDL 101
Q+ K L + ++E +E + Q L++D GD+FLH+A+ +AL+ + R++ L
Sbjct: 412 QLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNA-L 470
Query: 102 AFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVG 161
L+ + + Q+ +AV NQ I + L+ G D G TPLH+ E+G +
Sbjct: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQ 530
Query: 162 VLTQSCTTPHLHSILKATNYNGHTCLHLASI---------------------------HG 194
+ + + L+ATNY+G T LH A I
Sbjct: 531 AIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKS 590
Query: 195 YLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLK---CGADVNRVTYQGY 251
+ ++ L+ +GA V A++ +GRTALHLA + N +L+ L L+ C + VN Y G
Sbjct: 591 LVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGN 650
Query: 252 SPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESE 294
+ + + +Q +L QL L ++ + D + + E+E
Sbjct: 651 TALHV-----AASLQYRLTQLDAVRL-LMRKGADPSTRNLENE 687
Score = 30.8 bits (68), Expect = 1.7
Identities = 24/86 (27%), Positives = 39/86 (45%), Gaps = 11/86 (12%)
Query: 72 EDGDSFLHLAIIHEEKALTMEVIR---QVKGDLAFLNFQNNLQQTPLHLAVITN----QP 124
+ G + LHLA + +E+IR ++ L+F+N + T LH+A Q
Sbjct: 611 KSGRTALHLAA----EEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQL 666
Query: 125 EIAEALLGAGCDPELRDFRGNTPLHL 150
+ L+ G DP R+ P+HL
Sbjct: 667 DAVRLLMRKGADPSTRNLENEQPVHL 692
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 83.6 bits (205), Expect = 2e-16
Identities = 70/218 (32%), Positives = 103/218 (47%), Gaps = 29/218 (13%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVL--------- 163
TPLH+A NQ E+A +LL G +G TPLHLA ++G V +L
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 696
Query: 164 -TQSCTTP-HL---------------HSIL-KATNYNGHTCLHLASIHGYLGIVELLVSL 205
+S TP HL H ++ AT G+T LH+AS +G + +V+ L+
Sbjct: 697 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 756
Query: 206 GADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRI 265
ADVNA+ G + LH A + D+V+LLLK GA N V+ G +P + +
Sbjct: 757 QADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 815
Query: 266 QQQLGQLTLENLQMLPESEDEESY-DTESEFTEFTEDE 302
L +T E +L + S+ +T E + +EDE
Sbjct: 816 TDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDE 853
Score = 78.6 bits (192), Expect = 7e-15
Identities = 61/199 (30%), Positives = 93/199 (46%), Gaps = 21/199 (10%)
Query: 78 LHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDP 137
LH+A +A EV + + + A +N + QTPLH A + + LL +P
Sbjct: 474 LHMAA----RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 529
Query: 138 ELRDFRGNTPLHLACEQGCLASVGVL-----TQSCTTPHLHSILKATNYNGHTCLHLASI 192
L G+TPLH+A +G + +V L +Q+C T G T LH+A+
Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK-----------KGFTPLHVAAK 578
Query: 193 HGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYS 252
+G + + ELL+ A NA NG T LH+AV N D+V LLL G + + GY+
Sbjct: 579 YGKVRVAELLLERDAHPNAAGK-NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 637
Query: 253 PYQLTWGRPSTRIQQQLGQ 271
P + + + + L Q
Sbjct: 638 PLHIAAKQNQVEVARSLLQ 656
Score = 68.9 bits (167), Expect = 5e-12
Identities = 50/171 (29%), Positives = 81/171 (47%), Gaps = 28/171 (16%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCL----------ASVGV 162
TPLH+A +A+ LL G P R G TPLH+AC++ + AS+
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432
Query: 163 LTQSCTTP-HLHSIL----------------KATNYNGHTCLHLASIHGYLGIVELLVSL 205
+T+S TP H+ S + +N T LH+A+ G+ + + L+
Sbjct: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 492
Query: 206 GADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQL 256
A VNA+ + +T LH A + + ++V LLL+ A+ N T G++P +
Sbjct: 493 KAKVNAKAK-DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 542
Score = 68.6 bits (166), Expect = 7e-12
Identities = 77/263 (29%), Positives = 115/263 (43%), Gaps = 43/263 (16%)
Query: 32 SGLDSMKDEEYEQMVKEL--QEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKAL 89
+GL E + +MV EL +EI LE T+ G++ LH+A + +
Sbjct: 80 NGLHLASKEGHVKMVVELLHKEIILETT-------------TKKGNTALHIAALAGQD-- 124
Query: 90 TMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLH 149
EV+R++ A +N Q+ TPL++A N E+ + LL G + + G TPL
Sbjct: 125 --EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 182
Query: 150 LACEQGCLASVGVLTQSCT-----TPHLH-----------SILKATNYN-------GHTC 186
+A +QG V L T P LH ++L + N G T
Sbjct: 183 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 242
Query: 187 LHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRV 246
LH+A+ + L + +LL++ GA VN P NG T LH+A N +V LLL GA +
Sbjct: 243 LHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 301
Query: 247 TYQGYSPYQLTWGRPSTRIQQQL 269
T +P RI + L
Sbjct: 302 TKDELTPLHCAARNGHVRISEIL 324
Score = 66.6 bits (161), Expect = 3e-11
Identities = 47/144 (32%), Positives = 67/144 (46%), Gaps = 7/144 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TPLH+A + +AE LL P G TPLH+A L V +L +PH
Sbjct: 571 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH- 629
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
+ +NG+T LH+A+ + + L+ G NA E G T LHLA + ++
Sbjct: 630 -----SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA-ESVQGVTPLHLAAQEGHAEM 683
Query: 233 VSLLLKCGADVNRVTYQGYSPYQL 256
V+LLL A+ N G +P L
Sbjct: 684 VALLLSKQANGNLGNKSGLTPLHL 707
Score = 61.2 bits (147), Expect = 1e-09
Identities = 46/147 (31%), Positives = 70/147 (47%), Gaps = 19/147 (12%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQ------S 166
TPLH A I+E LL G + + G +P+H+A + L V +L Q
Sbjct: 307 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366
Query: 167 CTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVD 226
T HL T LH+A+ G+ + ++L+ GA N++ NG T LH+A
Sbjct: 367 ITLDHL------------TPLHVAAHCGHHRVAKVLLDKGAKPNSR-ALNGFTPLHIACK 413
Query: 227 LQNPDLVSLLLKCGADVNRVTYQGYSP 253
+ ++ LLLK GA ++ VT G +P
Sbjct: 414 KNHVRVMELLLKTGASIDAVTESGLTP 440
Score = 60.8 bits (146), Expect = 1e-09
Identities = 42/120 (35%), Positives = 63/120 (52%), Gaps = 7/120 (5%)
Query: 134 GCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIH 193
G D + G LHLA ++G + V L H IL+ T G+T LH+A++
Sbjct: 68 GVDINTCNQNGLNGLHLASKEGHVKMVVELL------HKEIILETTTKKGNTALHIAALA 121
Query: 194 GYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSP 253
G +V LV+ GA+VNAQ G T L++A + ++V LL+ GA+ N T G++P
Sbjct: 122 GQDEVVRELVNYGANVNAQSQ-KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 180
Score = 53.1 bits (126), Expect = 3e-07
Identities = 50/207 (24%), Positives = 88/207 (42%), Gaps = 11/207 (5%)
Query: 63 SEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITN 122
++P L++ G + LH+A +E + V + + A +NF TPLH+A
Sbjct: 228 NDPNPDVLSKTGFTPLHIAAHYEN----LNVAQLLLNRGASVNFTPQNGITPLHIASRRG 283
Query: 123 QPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYN 182
+ LL G E + TPLH A G + +L ++A N
Sbjct: 284 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP------IQAKTKN 337
Query: 183 GHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGAD 242
G + +H+A+ +L V LL+ A+++ + T LH+A + + +LL GA
Sbjct: 338 GLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 396
Query: 243 VNRVTYQGYSPYQLTWGRPSTRIQQQL 269
N G++P + + R+ + L
Sbjct: 397 PNSRALNGFTPLHIACKKNHVRVMELL 423
Score = 45.8 bits (107), Expect = 5e-05
Identities = 37/120 (30%), Positives = 53/120 (44%), Gaps = 7/120 (5%)
Query: 105 NFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLT 164
N N TPLHL +A+ L+ G + G TPLH+A G + V L
Sbjct: 695 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 754
Query: 165 QSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLA 224
Q + + A G++ LH A+ G+ IV LL+ GA N + +G T L +A
Sbjct: 755 QH------QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIA 807
Score = 31.2 bits (69), Expect = 1.3
Identities = 20/62 (32%), Positives = 27/62 (43%)
Query: 102 AFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVG 161
A +N + L +PLH A +I LL G P G TPL +A G ++
Sbjct: 758 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 817
Query: 162 VL 163
VL
Sbjct: 818 VL 819
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 83.6 bits (205), Expect = 2e-16
Identities = 70/218 (32%), Positives = 103/218 (47%), Gaps = 29/218 (13%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVL--------- 163
TPLH+A NQ E+A +LL G +G TPLHLA ++G V +L
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 164 -TQSCTTP-HL---------------HSIL-KATNYNGHTCLHLASIHGYLGIVELLVSL 205
+S TP HL H ++ AT G+T LH+AS +G + +V+ L+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 206 GADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRI 265
ADVNA+ G + LH A + D+V+LLLK GA N V+ G +P + +
Sbjct: 724 QADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Query: 266 QQQLGQLTLENLQMLPESEDEESY-DTESEFTEFTEDE 302
L +T E +L + S+ +T E + +EDE
Sbjct: 783 TDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDE 820
Score = 78.6 bits (192), Expect = 7e-15
Identities = 61/199 (30%), Positives = 93/199 (46%), Gaps = 21/199 (10%)
Query: 78 LHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDP 137
LH+A +A EV + + + A +N + QTPLH A + + LL +P
Sbjct: 441 LHMAA----RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 138 ELRDFRGNTPLHLACEQGCLASVGVL-----TQSCTTPHLHSILKATNYNGHTCLHLASI 192
L G+TPLH+A +G + +V L +Q+C T G T LH+A+
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK-----------KGFTPLHVAAK 545
Query: 193 HGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYS 252
+G + + ELL+ A NA NG T LH+AV N D+V LLL G + + GY+
Sbjct: 546 YGKVRVAELLLERDAHPNAAGK-NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604
Query: 253 PYQLTWGRPSTRIQQQLGQ 271
P + + + + L Q
Sbjct: 605 PLHIAAKQNQVEVARSLLQ 623
Score = 68.9 bits (167), Expect = 5e-12
Identities = 50/171 (29%), Positives = 81/171 (47%), Gaps = 28/171 (16%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCL----------ASVGV 162
TPLH+A +A+ LL G P R G TPLH+AC++ + AS+
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 163 LTQSCTTP-HLHSIL----------------KATNYNGHTCLHLASIHGYLGIVELLVSL 205
+T+S TP H+ S + +N T LH+A+ G+ + + L+
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 206 GADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQL 256
A VNA+ + +T LH A + + ++V LLL+ A+ N T G++P +
Sbjct: 460 KAKVNAKAK-DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
Score = 68.6 bits (166), Expect = 7e-12
Identities = 77/263 (29%), Positives = 115/263 (43%), Gaps = 43/263 (16%)
Query: 32 SGLDSMKDEEYEQMVKEL--QEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKAL 89
+GL E + +MV EL +EI LE T+ G++ LH+A + +
Sbjct: 47 NGLHLASKEGHVKMVVELLHKEIILETT-------------TKKGNTALHIAALAGQD-- 91
Query: 90 TMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLH 149
EV+R++ A +N Q+ TPL++A N E+ + LL G + + G TPL
Sbjct: 92 --EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 150 LACEQGCLASVGVLTQSCT-----TPHLH-----------SILKATNYN-------GHTC 186
+A +QG V L T P LH ++L + N G T
Sbjct: 150 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209
Query: 187 LHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRV 246
LH+A+ + L + +LL++ GA VN P NG T LH+A N +V LLL GA +
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 247 TYQGYSPYQLTWGRPSTRIQQQL 269
T +P RI + L
Sbjct: 269 TKDELTPLHCAARNGHVRISEIL 291
Score = 66.6 bits (161), Expect = 3e-11
Identities = 47/144 (32%), Positives = 67/144 (46%), Gaps = 7/144 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TPLH+A + +AE LL P G TPLH+A L V +L +PH
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH- 596
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
+ +NG+T LH+A+ + + L+ G NA E G T LHLA + ++
Sbjct: 597 -----SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA-ESVQGVTPLHLAAQEGHAEM 650
Query: 233 VSLLLKCGADVNRVTYQGYSPYQL 256
V+LLL A+ N G +P L
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHL 674
Score = 61.2 bits (147), Expect = 1e-09
Identities = 46/147 (31%), Positives = 70/147 (47%), Gaps = 19/147 (12%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQ------S 166
TPLH A I+E LL G + + G +P+H+A + L V +L Q
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 167 CTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVD 226
T HL T LH+A+ G+ + ++L+ GA N++ NG T LH+A
Sbjct: 334 ITLDHL------------TPLHVAAHCGHHRVAKVLLDKGAKPNSR-ALNGFTPLHIACK 380
Query: 227 LQNPDLVSLLLKCGADVNRVTYQGYSP 253
+ ++ LLLK GA ++ VT G +P
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTP 407
Score = 60.8 bits (146), Expect = 1e-09
Identities = 42/120 (35%), Positives = 63/120 (52%), Gaps = 7/120 (5%)
Query: 134 GCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIH 193
G D + G LHLA ++G + V L H IL+ T G+T LH+A++
Sbjct: 35 GVDINTCNQNGLNGLHLASKEGHVKMVVELL------HKEIILETTTKKGNTALHIAALA 88
Query: 194 GYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSP 253
G +V LV+ GA+VNAQ G T L++A + ++V LL+ GA+ N T G++P
Sbjct: 89 GQDEVVRELVNYGANVNAQSQ-KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147
Score = 53.1 bits (126), Expect = 3e-07
Identities = 50/207 (24%), Positives = 88/207 (42%), Gaps = 11/207 (5%)
Query: 63 SEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITN 122
++P L++ G + LH+A +E + V + + A +NF TPLH+A
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN----LNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 123 QPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYN 182
+ LL G E + TPLH A G + +L ++A N
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP------IQAKTKN 304
Query: 183 GHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGAD 242
G + +H+A+ +L V LL+ A+++ + T LH+A + + +LL GA
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 243 VNRVTYQGYSPYQLTWGRPSTRIQQQL 269
N G++P + + R+ + L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELL 390
Score = 45.8 bits (107), Expect = 5e-05
Identities = 37/120 (30%), Positives = 53/120 (44%), Gaps = 7/120 (5%)
Query: 105 NFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLT 164
N N TPLHL +A+ L+ G + G TPLH+A G + V L
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
Query: 165 QSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLA 224
Q + + A G++ LH A+ G+ IV LL+ GA N + +G T L +A
Sbjct: 722 QH------QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIA 774
Score = 31.2 bits (69), Expect = 1.3
Identities = 20/62 (32%), Positives = 27/62 (43%)
Query: 102 AFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVG 161
A +N + L +PLH A +I LL G P G TPL +A G ++
Sbjct: 725 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 784
Query: 162 VL 163
VL
Sbjct: 785 VL 786
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 83.6 bits (205), Expect = 2e-16
Identities = 70/218 (32%), Positives = 103/218 (47%), Gaps = 29/218 (13%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVL--------- 163
TPLH+A NQ E+A +LL G +G TPLHLA ++G V +L
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 164 -TQSCTTP-HL---------------HSIL-KATNYNGHTCLHLASIHGYLGIVELLVSL 205
+S TP HL H ++ AT G+T LH+AS +G + +V+ L+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 206 GADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRI 265
ADVNA+ G + LH A + D+V+LLLK GA N V+ G +P + +
Sbjct: 724 QADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Query: 266 QQQLGQLTLENLQMLPESEDEESY-DTESEFTEFTEDE 302
L +T E +L + S+ +T E + +EDE
Sbjct: 783 TDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDE 820
Score = 78.6 bits (192), Expect = 7e-15
Identities = 61/199 (30%), Positives = 93/199 (46%), Gaps = 21/199 (10%)
Query: 78 LHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDP 137
LH+A +A EV + + + A +N + QTPLH A + + LL +P
Sbjct: 441 LHMAA----RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 138 ELRDFRGNTPLHLACEQGCLASVGVL-----TQSCTTPHLHSILKATNYNGHTCLHLASI 192
L G+TPLH+A +G + +V L +Q+C T G T LH+A+
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK-----------KGFTPLHVAAK 545
Query: 193 HGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYS 252
+G + + ELL+ A NA NG T LH+AV N D+V LLL G + + GY+
Sbjct: 546 YGKVRVAELLLERDAHPNAAGK-NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604
Query: 253 PYQLTWGRPSTRIQQQLGQ 271
P + + + + L Q
Sbjct: 605 PLHIAAKQNQVEVARSLLQ 623
Score = 68.9 bits (167), Expect = 5e-12
Identities = 50/171 (29%), Positives = 81/171 (47%), Gaps = 28/171 (16%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCL----------ASVGV 162
TPLH+A +A+ LL G P R G TPLH+AC++ + AS+
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 163 LTQSCTTP-HLHSIL----------------KATNYNGHTCLHLASIHGYLGIVELLVSL 205
+T+S TP H+ S + +N T LH+A+ G+ + + L+
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 206 GADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQL 256
A VNA+ + +T LH A + + ++V LLL+ A+ N T G++P +
Sbjct: 460 KAKVNAKAK-DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
Score = 68.6 bits (166), Expect = 7e-12
Identities = 77/263 (29%), Positives = 115/263 (43%), Gaps = 43/263 (16%)
Query: 32 SGLDSMKDEEYEQMVKEL--QEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKAL 89
+GL E + +MV EL +EI LE T+ G++ LH+A + +
Sbjct: 47 NGLHLASKEGHVKMVVELLHKEIILETT-------------TKKGNTALHIAALAGQD-- 91
Query: 90 TMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLH 149
EV+R++ A +N Q+ TPL++A N E+ + LL G + + G TPL
Sbjct: 92 --EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 150 LACEQGCLASVGVLTQSCT-----TPHLH-----------SILKATNYN-------GHTC 186
+A +QG V L T P LH ++L + N G T
Sbjct: 150 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209
Query: 187 LHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRV 246
LH+A+ + L + +LL++ GA VN P NG T LH+A N +V LLL GA +
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 247 TYQGYSPYQLTWGRPSTRIQQQL 269
T +P RI + L
Sbjct: 269 TKDELTPLHCAARNGHVRISEIL 291
Score = 66.6 bits (161), Expect = 3e-11
Identities = 47/144 (32%), Positives = 67/144 (46%), Gaps = 7/144 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TPLH+A + +AE LL P G TPLH+A L V +L +PH
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH- 596
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
+ +NG+T LH+A+ + + L+ G NA E G T LHLA + ++
Sbjct: 597 -----SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA-ESVQGVTPLHLAAQEGHAEM 650
Query: 233 VSLLLKCGADVNRVTYQGYSPYQL 256
V+LLL A+ N G +P L
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHL 674
Score = 61.2 bits (147), Expect = 1e-09
Identities = 46/147 (31%), Positives = 70/147 (47%), Gaps = 19/147 (12%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQ------S 166
TPLH A I+E LL G + + G +P+H+A + L V +L Q
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 167 CTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVD 226
T HL T LH+A+ G+ + ++L+ GA N++ NG T LH+A
Sbjct: 334 ITLDHL------------TPLHVAAHCGHHRVAKVLLDKGAKPNSR-ALNGFTPLHIACK 380
Query: 227 LQNPDLVSLLLKCGADVNRVTYQGYSP 253
+ ++ LLLK GA ++ VT G +P
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTP 407
Score = 60.8 bits (146), Expect = 1e-09
Identities = 42/120 (35%), Positives = 63/120 (52%), Gaps = 7/120 (5%)
Query: 134 GCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIH 193
G D + G LHLA ++G + V L H IL+ T G+T LH+A++
Sbjct: 35 GVDINTCNQNGLNGLHLASKEGHVKMVVELL------HKEIILETTTKKGNTALHIAALA 88
Query: 194 GYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSP 253
G +V LV+ GA+VNAQ G T L++A + ++V LL+ GA+ N T G++P
Sbjct: 89 GQDEVVRELVNYGANVNAQSQ-KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147
Score = 53.1 bits (126), Expect = 3e-07
Identities = 50/207 (24%), Positives = 88/207 (42%), Gaps = 11/207 (5%)
Query: 63 SEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITN 122
++P L++ G + LH+A +E + V + + A +NF TPLH+A
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN----LNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 123 QPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYN 182
+ LL G E + TPLH A G + +L ++A N
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP------IQAKTKN 304
Query: 183 GHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGAD 242
G + +H+A+ +L V LL+ A+++ + T LH+A + + +LL GA
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 243 VNRVTYQGYSPYQLTWGRPSTRIQQQL 269
N G++P + + R+ + L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELL 390
Score = 45.8 bits (107), Expect = 5e-05
Identities = 37/120 (30%), Positives = 53/120 (44%), Gaps = 7/120 (5%)
Query: 105 NFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLT 164
N N TPLHL +A+ L+ G + G TPLH+A G + V L
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
Query: 165 QSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLA 224
Q + + A G++ LH A+ G+ IV LL+ GA N + +G T L +A
Sbjct: 722 QH------QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIA 774
Score = 31.2 bits (69), Expect = 1.3
Identities = 20/62 (32%), Positives = 27/62 (43%)
Query: 102 AFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVG 161
A +N + L +PLH A +I LL G P G TPL +A G ++
Sbjct: 725 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 784
Query: 162 VL 163
VL
Sbjct: 785 VL 786
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 83.6 bits (205), Expect = 2e-16
Identities = 70/218 (32%), Positives = 103/218 (47%), Gaps = 29/218 (13%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVL--------- 163
TPLH+A NQ E+A +LL G +G TPLHLA ++G V +L
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 164 -TQSCTTP-HL---------------HSIL-KATNYNGHTCLHLASIHGYLGIVELLVSL 205
+S TP HL H ++ AT G+T LH+AS +G + +V+ L+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 206 GADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRI 265
ADVNA+ G + LH A + D+V+LLLK GA N V+ G +P + +
Sbjct: 724 QADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Query: 266 QQQLGQLTLENLQMLPESEDEESY-DTESEFTEFTEDE 302
L +T E +L + S+ +T E + +EDE
Sbjct: 783 TDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDE 820
Score = 78.6 bits (192), Expect = 7e-15
Identities = 61/199 (30%), Positives = 93/199 (46%), Gaps = 21/199 (10%)
Query: 78 LHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDP 137
LH+A +A EV + + + A +N + QTPLH A + + LL +P
Sbjct: 441 LHMAA----RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 138 ELRDFRGNTPLHLACEQGCLASVGVL-----TQSCTTPHLHSILKATNYNGHTCLHLASI 192
L G+TPLH+A +G + +V L +Q+C T G T LH+A+
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK-----------KGFTPLHVAAK 545
Query: 193 HGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYS 252
+G + + ELL+ A NA NG T LH+AV N D+V LLL G + + GY+
Sbjct: 546 YGKVRVAELLLERDAHPNAAGK-NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604
Query: 253 PYQLTWGRPSTRIQQQLGQ 271
P + + + + L Q
Sbjct: 605 PLHIAAKQNQVEVARSLLQ 623
Score = 68.9 bits (167), Expect = 5e-12
Identities = 50/171 (29%), Positives = 81/171 (47%), Gaps = 28/171 (16%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCL----------ASVGV 162
TPLH+A +A+ LL G P R G TPLH+AC++ + AS+
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 163 LTQSCTTP-HLHSIL----------------KATNYNGHTCLHLASIHGYLGIVELLVSL 205
+T+S TP H+ S + +N T LH+A+ G+ + + L+
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 206 GADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQL 256
A VNA+ + +T LH A + + ++V LLL+ A+ N T G++P +
Sbjct: 460 KAKVNAKAK-DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
Score = 68.6 bits (166), Expect = 7e-12
Identities = 77/263 (29%), Positives = 115/263 (43%), Gaps = 43/263 (16%)
Query: 32 SGLDSMKDEEYEQMVKEL--QEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKAL 89
+GL E + +MV EL +EI LE T+ G++ LH+A + +
Sbjct: 47 NGLHLASKEGHVKMVVELLHKEIILETT-------------TKKGNTALHIAALAGQD-- 91
Query: 90 TMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLH 149
EV+R++ A +N Q+ TPL++A N E+ + LL G + + G TPL
Sbjct: 92 --EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 150 LACEQGCLASVGVLTQSCT-----TPHLH-----------SILKATNYN-------GHTC 186
+A +QG V L T P LH ++L + N G T
Sbjct: 150 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209
Query: 187 LHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRV 246
LH+A+ + L + +LL++ GA VN P NG T LH+A N +V LLL GA +
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 247 TYQGYSPYQLTWGRPSTRIQQQL 269
T +P RI + L
Sbjct: 269 TKDELTPLHCAARNGHVRISEIL 291
Score = 66.6 bits (161), Expect = 3e-11
Identities = 47/144 (32%), Positives = 67/144 (46%), Gaps = 7/144 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TPLH+A + +AE LL P G TPLH+A L V +L +PH
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH- 596
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
+ +NG+T LH+A+ + + L+ G NA E G T LHLA + ++
Sbjct: 597 -----SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA-ESVQGVTPLHLAAQEGHAEM 650
Query: 233 VSLLLKCGADVNRVTYQGYSPYQL 256
V+LLL A+ N G +P L
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHL 674
Score = 61.2 bits (147), Expect = 1e-09
Identities = 46/147 (31%), Positives = 70/147 (47%), Gaps = 19/147 (12%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQ------S 166
TPLH A I+E LL G + + G +P+H+A + L V +L Q
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 167 CTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVD 226
T HL T LH+A+ G+ + ++L+ GA N++ NG T LH+A
Sbjct: 334 ITLDHL------------TPLHVAAHCGHHRVAKVLLDKGAKPNSR-ALNGFTPLHIACK 380
Query: 227 LQNPDLVSLLLKCGADVNRVTYQGYSP 253
+ ++ LLLK GA ++ VT G +P
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTP 407
Score = 60.8 bits (146), Expect = 1e-09
Identities = 42/120 (35%), Positives = 63/120 (52%), Gaps = 7/120 (5%)
Query: 134 GCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIH 193
G D + G LHLA ++G + V L H IL+ T G+T LH+A++
Sbjct: 35 GVDINTCNQNGLNGLHLASKEGHVKMVVELL------HKEIILETTTKKGNTALHIAALA 88
Query: 194 GYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSP 253
G +V LV+ GA+VNAQ G T L++A + ++V LL+ GA+ N T G++P
Sbjct: 89 GQDEVVRELVNYGANVNAQSQ-KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147
Score = 53.1 bits (126), Expect = 3e-07
Identities = 50/207 (24%), Positives = 88/207 (42%), Gaps = 11/207 (5%)
Query: 63 SEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITN 122
++P L++ G + LH+A +E + V + + A +NF TPLH+A
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN----LNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 123 QPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYN 182
+ LL G E + TPLH A G + +L ++A N
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP------IQAKTKN 304
Query: 183 GHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGAD 242
G + +H+A+ +L V LL+ A+++ + T LH+A + + +LL GA
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 243 VNRVTYQGYSPYQLTWGRPSTRIQQQL 269
N G++P + + R+ + L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELL 390
Score = 45.8 bits (107), Expect = 5e-05
Identities = 37/120 (30%), Positives = 53/120 (44%), Gaps = 7/120 (5%)
Query: 105 NFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLT 164
N N TPLHL +A+ L+ G + G TPLH+A G + V L
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
Query: 165 QSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLA 224
Q + + A G++ LH A+ G+ IV LL+ GA N + +G T L +A
Sbjct: 722 QH------QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIA 774
Score = 31.2 bits (69), Expect = 1.3
Identities = 20/62 (32%), Positives = 27/62 (43%)
Query: 102 AFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVG 161
A +N + L +PLH A +I LL G P G TPL +A G ++
Sbjct: 725 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 784
Query: 162 VL 163
VL
Sbjct: 785 VL 786
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 83.6 bits (205), Expect = 2e-16
Identities = 70/218 (32%), Positives = 103/218 (47%), Gaps = 29/218 (13%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVL--------- 163
TPLH+A NQ E+A +LL G +G TPLHLA ++G V +L
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 164 -TQSCTTP-HL---------------HSIL-KATNYNGHTCLHLASIHGYLGIVELLVSL 205
+S TP HL H ++ AT G+T LH+AS +G + +V+ L+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 206 GADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRI 265
ADVNA+ G + LH A + D+V+LLLK GA N V+ G +P + +
Sbjct: 724 QADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Query: 266 QQQLGQLTLENLQMLPESEDEESY-DTESEFTEFTEDE 302
L +T E +L + S+ +T E + +EDE
Sbjct: 783 TDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDE 820
Score = 78.6 bits (192), Expect = 7e-15
Identities = 61/199 (30%), Positives = 93/199 (46%), Gaps = 21/199 (10%)
Query: 78 LHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDP 137
LH+A +A EV + + + A +N + QTPLH A + + LL +P
Sbjct: 441 LHMAA----RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 138 ELRDFRGNTPLHLACEQGCLASVGVL-----TQSCTTPHLHSILKATNYNGHTCLHLASI 192
L G+TPLH+A +G + +V L +Q+C T G T LH+A+
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK-----------KGFTPLHVAAK 545
Query: 193 HGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYS 252
+G + + ELL+ A NA NG T LH+AV N D+V LLL G + + GY+
Sbjct: 546 YGKVRVAELLLERDAHPNAAGK-NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604
Query: 253 PYQLTWGRPSTRIQQQLGQ 271
P + + + + L Q
Sbjct: 605 PLHIAAKQNQVEVARSLLQ 623
Score = 68.9 bits (167), Expect = 5e-12
Identities = 50/171 (29%), Positives = 81/171 (47%), Gaps = 28/171 (16%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCL----------ASVGV 162
TPLH+A +A+ LL G P R G TPLH+AC++ + AS+
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 163 LTQSCTTP-HLHSIL----------------KATNYNGHTCLHLASIHGYLGIVELLVSL 205
+T+S TP H+ S + +N T LH+A+ G+ + + L+
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 206 GADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQL 256
A VNA+ + +T LH A + + ++V LLL+ A+ N T G++P +
Sbjct: 460 KAKVNAKAK-DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
Score = 68.6 bits (166), Expect = 7e-12
Identities = 77/263 (29%), Positives = 115/263 (43%), Gaps = 43/263 (16%)
Query: 32 SGLDSMKDEEYEQMVKEL--QEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKAL 89
+GL E + +MV EL +EI LE T+ G++ LH+A + +
Sbjct: 47 NGLHLASKEGHVKMVVELLHKEIILETT-------------TKKGNTALHIAALAGQD-- 91
Query: 90 TMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLH 149
EV+R++ A +N Q+ TPL++A N E+ + LL G + + G TPL
Sbjct: 92 --EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 150 LACEQGCLASVGVLTQSCT-----TPHLH-----------SILKATNYN-------GHTC 186
+A +QG V L T P LH ++L + N G T
Sbjct: 150 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209
Query: 187 LHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRV 246
LH+A+ + L + +LL++ GA VN P NG T LH+A N +V LLL GA +
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 247 TYQGYSPYQLTWGRPSTRIQQQL 269
T +P RI + L
Sbjct: 269 TKDELTPLHCAARNGHVRISEIL 291
Score = 66.6 bits (161), Expect = 3e-11
Identities = 47/144 (32%), Positives = 67/144 (46%), Gaps = 7/144 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TPLH+A + +AE LL P G TPLH+A L V +L +PH
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH- 596
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
+ +NG+T LH+A+ + + L+ G NA E G T LHLA + ++
Sbjct: 597 -----SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA-ESVQGVTPLHLAAQEGHAEM 650
Query: 233 VSLLLKCGADVNRVTYQGYSPYQL 256
V+LLL A+ N G +P L
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHL 674
Score = 61.2 bits (147), Expect = 1e-09
Identities = 46/147 (31%), Positives = 70/147 (47%), Gaps = 19/147 (12%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQ------S 166
TPLH A I+E LL G + + G +P+H+A + L V +L Q
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 167 CTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVD 226
T HL T LH+A+ G+ + ++L+ GA N++ NG T LH+A
Sbjct: 334 ITLDHL------------TPLHVAAHCGHHRVAKVLLDKGAKPNSR-ALNGFTPLHIACK 380
Query: 227 LQNPDLVSLLLKCGADVNRVTYQGYSP 253
+ ++ LLLK GA ++ VT G +P
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTP 407
Score = 60.8 bits (146), Expect = 1e-09
Identities = 42/120 (35%), Positives = 63/120 (52%), Gaps = 7/120 (5%)
Query: 134 GCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIH 193
G D + G LHLA ++G + V L H IL+ T G+T LH+A++
Sbjct: 35 GVDINTCNQNGLNGLHLASKEGHVKMVVELL------HKEIILETTTKKGNTALHIAALA 88
Query: 194 GYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSP 253
G +V LV+ GA+VNAQ G T L++A + ++V LL+ GA+ N T G++P
Sbjct: 89 GQDEVVRELVNYGANVNAQSQ-KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147
Score = 53.1 bits (126), Expect = 3e-07
Identities = 50/207 (24%), Positives = 88/207 (42%), Gaps = 11/207 (5%)
Query: 63 SEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITN 122
++P L++ G + LH+A +E + V + + A +NF TPLH+A
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN----LNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 123 QPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYN 182
+ LL G E + TPLH A G + +L ++A N
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP------IQAKTKN 304
Query: 183 GHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGAD 242
G + +H+A+ +L V LL+ A+++ + T LH+A + + +LL GA
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 243 VNRVTYQGYSPYQLTWGRPSTRIQQQL 269
N G++P + + R+ + L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELL 390
Score = 45.8 bits (107), Expect = 5e-05
Identities = 37/120 (30%), Positives = 53/120 (44%), Gaps = 7/120 (5%)
Query: 105 NFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLT 164
N N TPLHL +A+ L+ G + G TPLH+A G + V L
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
Query: 165 QSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLA 224
Q + + A G++ LH A+ G+ IV LL+ GA N + +G T L +A
Sbjct: 722 QH------QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIA 774
Score = 31.2 bits (69), Expect = 1.3
Identities = 20/62 (32%), Positives = 27/62 (43%)
Query: 102 AFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVG 161
A +N + L +PLH A +I LL G P G TPL +A G ++
Sbjct: 725 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 784
Query: 162 VL 163
VL
Sbjct: 785 VL 786
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 80.9 bits (198), Expect = 1e-15
Identities = 55/174 (31%), Positives = 89/174 (51%), Gaps = 7/174 (4%)
Query: 102 AFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVG 161
A +N ++N+ TPLH AV + E + L+ D RD TPLH+A A+
Sbjct: 40 ARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAA-----ANKA 94
Query: 162 VLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTAL 221
V P L S+ ++ G T LH A+++G++ +V LL++ GA++NA + R AL
Sbjct: 95 VKCAEVIIPLLSSV-NVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDK-KDRRAL 152
Query: 222 HLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLE 275
H A + + D+V+LL+ GA+V +GY+P + + L L +E
Sbjct: 153 HWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVE 206
Score = 65.9 bits (159), Expect = 5e-11
Identities = 67/252 (26%), Positives = 107/252 (42%), Gaps = 39/252 (15%)
Query: 69 QLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAE 128
Q +G + LH A AL +E++ D+ N Q+ ++PLH+ + + ++
Sbjct: 242 QPNNNGFTPLHFAAASTHGALCLELLVNNGADV---NIQSKDGKSPLHMTAVHGRFTRSQ 298
Query: 129 ALLGAGCDPELRDFRGNTPLHLACEQG------CLASVGVLTQSCTTPHLHSI----LKA 178
L+ G + + D GNTPLH+A G L + G T C +HS+ L A
Sbjct: 299 TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKC---GIHSMFPLHLAA 355
Query: 179 TNYN--------------------GHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGR 218
N + G TCLH A+ G + ++LL S GAD + ++ C GR
Sbjct: 356 LNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKC-GR 414
Query: 219 TALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQL--TLEN 276
T LH A + + L+ GA+VN G + R + LG E
Sbjct: 415 TPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEE 474
Query: 277 LQMLPESEDEES 288
L+ E +++E+
Sbjct: 475 LERARELKEKEA 486
Score = 65.5 bits (158), Expect = 6e-11
Identities = 55/185 (29%), Positives = 85/185 (45%), Gaps = 12/185 (6%)
Query: 74 GDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGA 133
G + LH A ++ +E++ + A +N + + LH A ++ L+
Sbjct: 115 GRTALHHAALNGH----VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
Query: 134 GCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIH 193
G + +D +G TPLH A G + V L +L + N G+T LH+A +
Sbjct: 171 GAEVTCKDKKGYTPLHAAASNGQINVVKHLL------NLGVEIDEINVYGNTALHIACYN 224
Query: 194 GYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL-VSLLLKCGADVNRVTYQGYS 252
G +V L+ GA+VN Q NG T LH A + L + LL+ GADVN + G S
Sbjct: 225 GQDAVVNELIDYGANVN-QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKS 283
Query: 253 PYQLT 257
P +T
Sbjct: 284 PLHMT 288
Score = 61.6 bits (148), Expect = 9e-10
Identities = 49/143 (34%), Positives = 69/143 (48%), Gaps = 10/143 (6%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TPLH A Q + + LL G + + + GNT LH+AC G A V L
Sbjct: 183 TPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELID------Y 236
Query: 173 HSILKATNYNGHTCLHL--ASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNP 230
+ + N NG T LH AS HG L +ELLV+ GADVN Q +G++ LH+
Sbjct: 237 GANVNQPNNNGFTPLHFAAASTHGAL-CLELLVNNGADVNIQSK-DGKSPLHMTAVHGRF 294
Query: 231 DLVSLLLKCGADVNRVTYQGYSP 253
L++ G +++ V G +P
Sbjct: 295 TRSQTLIQNGGEIDCVDKDGNTP 317
Score = 57.8 bits (138), Expect = 1e-08
Identities = 42/153 (27%), Positives = 74/153 (48%), Gaps = 7/153 (4%)
Query: 101 LAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASV 160
L+ +N + +T LH A + E+ LL G + D + LH A G L V
Sbjct: 105 LSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVV 164
Query: 161 GVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTA 220
+L + + + G+T LH A+ +G + +V+ L++LG +++ + G TA
Sbjct: 165 ALLINH------GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTA 217
Query: 221 LHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSP 253
LH+A +V+ L+ GA+VN+ G++P
Sbjct: 218 LHIACYNGQDAVVNELIDYGANVNQPNNNGFTP 250
Score = 56.2 bits (134), Expect = 4e-08
Identities = 50/181 (27%), Positives = 81/181 (44%), Gaps = 9/181 (4%)
Query: 72 EDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALL 131
++G + +H A + + ++ + F + ++PLHLA + E LL
Sbjct: 505 KEGYNSIHYAAAYGHRQCLELLLERTNS--GFEESDSGATKSPLHLAAYNGHHQALEVLL 562
Query: 132 GAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLAS 191
+ D ++RD +G T L LA +G V L SI N T LH +
Sbjct: 563 QSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGA-----SIFVKDNVTKRTPLHASV 617
Query: 192 IHGYLGIVELLVSLGADVNAQE--PCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQ 249
I+G+ + LL+ + + A + G+T L LAV + D VSLLL+ A+V+ V
Sbjct: 618 INGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDIL 677
Query: 250 G 250
G
Sbjct: 678 G 678
Score = 44.3 bits (103), Expect = 1e-04
Identities = 41/129 (31%), Positives = 62/129 (48%), Gaps = 12/129 (9%)
Query: 113 TPLHLAVITNQPEIAEALLGA--GCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTP 170
TPLH A+I + A LLGA RD +G TPL A + + +L +
Sbjct: 781 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLR----- 835
Query: 171 HLHSI-LKATNYNGHTCLHLASIHGYLGIVELLV-SLGADVNAQEPCNGRTALHLAVDLQ 228
HS + A + +G T L +A+ +G G V++LV S AD+ ++ + T LHLA
Sbjct: 836 --HSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDK-DLNTPLHLACSKG 892
Query: 229 NPDLVSLLL 237
+ L+L
Sbjct: 893 HEKCALLIL 901
Score = 43.5 bits (101), Expect = 2e-04
Identities = 42/144 (29%), Positives = 59/144 (40%), Gaps = 13/144 (9%)
Query: 112 QTPLHLAVITNQPEIAEALLGAGCDPE---LRDFRGNTPLHLACEQGCLASVGVLT-QSC 167
+TPLH A LL E +D +G TPLH AC G + VL Q C
Sbjct: 712 RTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC 771
Query: 168 TTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLV-SLGADVNAQEPCNGRTALHLAVD 226
+ N T LH A I+ + LL+ ++ + + + GRT L A
Sbjct: 772 FRKFIG--------NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAF 823
Query: 227 LQNPDLVSLLLKCGADVNRVTYQG 250
+ + + LLL+ A VN V G
Sbjct: 824 ADHVECLQLLLRHSAPVNAVDNSG 847
Score = 40.8 bits (94), Expect = 0.002
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 5/116 (4%)
Query: 128 EALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCL 187
E LL +P +RD G +H A G + +L + + S AT + L
Sbjct: 491 EFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK----SPL 546
Query: 188 HLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADV 243
HLA+ +G+ +E+L+ D++ ++ GRTAL LA + + V L+ GA +
Sbjct: 547 HLAAYNGHHQALEVLLQSLVDLDIRDE-KGRTALDLAAFKGHTECVEALINPGASI 601
Score = 39.7 bits (91), Expect = 0.004
Identities = 36/131 (27%), Positives = 54/131 (41%), Gaps = 17/131 (12%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
T LH ++T E + LL +D RG TPLH A +G + L Q +
Sbjct: 680 TALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALS--- 736
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPC------NGRTALHLAVD 226
+ G+T LH A +G +E+L+ ++ C N T LH A+
Sbjct: 737 EEDCCFKDNQGYTPLHWACYNGNENCIEVLL--------EQKCFRKFIGNPFTPLHCAII 788
Query: 227 LQNPDLVSLLL 237
+ + SLLL
Sbjct: 789 NDHGNCASLLL 799
Score = 35.4 bits (80), Expect = 0.067
Identities = 30/118 (25%), Positives = 52/118 (44%), Gaps = 7/118 (5%)
Query: 78 LHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDP 137
LH AII++ ++ + D + ++ +++ +TPL A + E + LL
Sbjct: 783 LHCAIINDHGNCASLLLGAI--DSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV 840
Query: 138 ELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGY 195
D G T L +A E G +V +L S + L + + +T LHLA G+
Sbjct: 841 NAVDNSGKTALMMAAENGQAGAVDILVNSA-----QADLTVKDKDLNTPLHLACSKGH 893
Score = 35.0 bits (79), Expect = 0.088
Identities = 38/166 (22%), Positives = 70/166 (42%), Gaps = 15/166 (9%)
Query: 78 LHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDP 137
LH ++I+ L + ++ ++ + ++ ++ QTPL LAV + LL +
Sbjct: 613 LHASVINGH-TLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANV 671
Query: 138 ELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLG 197
+ D G T LH G V +L + + + + G T LH A+ G+
Sbjct: 672 DTVDILGCTALHRGIMTGHEECVQMLLEQEVS------ILCKDSRGRTPLHYAAARGHAT 725
Query: 198 IVELLVSLGADVNAQEPC-----NGRTALHLAVDLQNPDLVSLLLK 238
+ L+ + ++E C G T LH A N + + +LL+
Sbjct: 726 WLSELLQMAL---SEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 79.0 bits (193), Expect = 5e-15
Identities = 58/182 (31%), Positives = 92/182 (50%), Gaps = 11/182 (6%)
Query: 72 EDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALL 131
++G + LH+A ++ + + + ++ KG +N TPLH+A NQ +IA LL
Sbjct: 573 KNGLTPLHVAAHYDNQKVALLLLE--KGASPHATAKNGY--TPLHIAAKKNQMQIASTLL 628
Query: 132 GAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLAS 191
G + + +G TPLHLA ++G V +L H+ + +G T LHLA+
Sbjct: 629 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM------STKSGLTSLHLAA 682
Query: 192 IHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGY 251
+ + ++L GAD +A G T L +A N +V+ LLK GA+VN T GY
Sbjct: 683 QEDKVNVADILTKHGADQDAHTKL-GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY 741
Query: 252 SP 253
+P
Sbjct: 742 TP 743
Score = 76.6 bits (187), Expect = 3e-14
Identities = 57/196 (29%), Positives = 96/196 (48%), Gaps = 11/196 (5%)
Query: 74 GDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGA 133
G++ LH+A +A +EV+R + + A ++ + +QTPLH+A + EI + LL
Sbjct: 443 GETALHMAA----RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
Query: 134 GCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIH 193
P+ G TPLH++ +G + VL ++ HS+ G T LH+A+ +
Sbjct: 499 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA---HSL---ATKKGFTPLHVAAKY 552
Query: 194 GYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSP 253
G L + +LL+ A ++ NG T LH+A N + LLL+ GA + GY+P
Sbjct: 553 GSLDVAKLLLQRRAAADSAGK-NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTP 611
Query: 254 YQLTWGRPSTRIQQQL 269
+ + +I L
Sbjct: 612 LHIAAKKNQMQIASTL 627
Score = 73.2 bits (178), Expect = 3e-13
Identities = 50/144 (34%), Positives = 70/144 (48%), Gaps = 7/144 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TPLH++ Q ++A LL AG L +G TPLH+A + G L +L Q
Sbjct: 511 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR------ 564
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
+ + NG T LH+A+ + + LL+ GA +A NG T LH+A +
Sbjct: 565 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK-NGYTPLHIAAKKNQMQI 623
Query: 233 VSLLLKCGADVNRVTYQGYSPYQL 256
S LL GA+ N VT QG +P L
Sbjct: 624 ASTLLNYGAETNIVTKQGVTPLHL 647
Score = 69.3 bits (168), Expect = 4e-12
Identities = 48/145 (33%), Positives = 76/145 (52%), Gaps = 7/145 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TPLH+A N+ ++ E L+ G + G TP+H+A G L V +L Q+ +P +
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
TN G T LH+A+ G + +V L+ GA V+A+ +T LH+A L ++
Sbjct: 439 ------TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAR-EEQTPLHIASRLGKTEI 491
Query: 233 VSLLLKCGADVNRVTYQGYSPYQLT 257
V LLL+ A + T GY+P ++
Sbjct: 492 VQLLLQHMAHPDAATTNGYTPLHIS 516
Score = 68.2 bits (165), Expect = 9e-12
Identities = 68/255 (26%), Positives = 116/255 (45%), Gaps = 44/255 (17%)
Query: 30 HDSGLDSMKDEEYEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKAL 89
+ +GL+++ E V +QE+ + RGS T+ G++ LH+A + A
Sbjct: 40 NQNGLNALHLAAKEGHVGLVQEL------LGRGSSV--DSATKKGNTALHIASL----AG 87
Query: 90 TMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLH 149
EV++ + + A +N Q+ TPL++A N ++ + LL G + G TPL
Sbjct: 88 QAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 147
Query: 150 LACEQGCLASVGVLTQSCT-----TPHLH--------------------------SILKA 178
+A +QG +V +L ++ T P LH ++
Sbjct: 148 VALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNR 207
Query: 179 TNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLK 238
T +G T LH+A+ +G + + LL++ GA V+ NG T LH+A N ++V LLL
Sbjct: 208 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTAR-NGITPLHVASKRGNTNMVKLLLD 266
Query: 239 CGADVNRVTYQGYSP 253
G ++ T G +P
Sbjct: 267 RGGQIDAKTRDGLTP 281
Score = 63.2 bits (152), Expect = 3e-10
Identities = 45/141 (31%), Positives = 70/141 (49%), Gaps = 7/141 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TP+H+A I LL G P++ + RG T LH+A G + V L ++
Sbjct: 412 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN------ 465
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
+++ A T LH+AS G IV+LL+ A +A NG T LH++ D+
Sbjct: 466 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA-ATTNGYTPLHISAREGQVDV 524
Query: 233 VSLLLKCGADVNRVTYQGYSP 253
S+LL+ GA + T +G++P
Sbjct: 525 ASVLLEAGAAHSLATKKGFTP 545
Score = 58.2 bits (139), Expect = 1e-08
Identities = 44/141 (31%), Positives = 68/141 (48%), Gaps = 7/141 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TPLH A + ++ E LL G R G +PLH+A + + V L Q H
Sbjct: 280 TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ-----HK 334
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
+ T + T LH+A+ G+ + +LL+ A+ NA+ NG T LH+A +
Sbjct: 335 APVDDVT-LDYLTALHVAAHCGHYRVTKLLLDKRANPNAR-ALNGFTPLHIACKKNRIKV 392
Query: 233 VSLLLKCGADVNRVTYQGYSP 253
+ LL+K GA + +T G +P
Sbjct: 393 MELLVKYGASIQAITESGLTP 413
Score = 52.8 bits (125), Expect = 4e-07
Identities = 27/78 (34%), Positives = 47/78 (60%), Gaps = 1/78 (1%)
Query: 176 LKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSL 235
+ N NG LHLA+ G++G+V+ L+ G+ V++ G TALH+A ++V +
Sbjct: 36 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK-KGNTALHIASLAGQAEVVKV 94
Query: 236 LLKCGADVNRVTYQGYSP 253
L+K GA++N + G++P
Sbjct: 95 LVKEGANINAQSQNGFTP 112
Score = 51.2 bits (121), Expect = 1e-06
Identities = 40/132 (30%), Positives = 61/132 (46%), Gaps = 10/132 (7%)
Query: 71 TEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEAL 130
T+ G + LHLA E+K +++ + D + L TPL +A ++ L
Sbjct: 671 TKSGLTSLHLAA-QEDKVNVADILTKHGADQ---DAHTKLGYTPLIVACHYGNVKMVNFL 726
Query: 131 LGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLA 190
L G + + G TPLH A +QG + VL Q P+ AT NG+T L +A
Sbjct: 727 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN------ATTANGNTALAIA 780
Query: 191 SIHGYLGIVELL 202
GY+ +V+ L
Sbjct: 781 KRLGYISVVDTL 792
Score = 50.8 bits (120), Expect = 2e-06
Identities = 43/162 (26%), Positives = 68/162 (41%), Gaps = 41/162 (25%)
Query: 92 EVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLA 151
+V+ +KG + +N N LHLA + + LLG G + +GNT LH
Sbjct: 25 KVVEYLKGGID-INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH-- 81
Query: 152 CEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNA 211
+AS+ G +V++LV GA++NA
Sbjct: 82 -------------------------------------IASLAGQAEVVKVLVKEGANINA 104
Query: 212 QEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSP 253
Q NG T L++A + D+V LL+ GA+ + T G++P
Sbjct: 105 QSQ-NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 145
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 79.0 bits (193), Expect = 5e-15
Identities = 58/182 (31%), Positives = 92/182 (50%), Gaps = 11/182 (6%)
Query: 72 EDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALL 131
++G + LH+A ++ + + + ++ KG +N TPLH+A NQ +IA LL
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLE--KGASPHATAKNGY--TPLHIAAKKNQMQIASTLL 649
Query: 132 GAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLAS 191
G + + +G TPLHLA ++G V +L H+ + +G T LHLA+
Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM------STKSGLTSLHLAA 703
Query: 192 IHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGY 251
+ + ++L GAD +A G T L +A N +V+ LLK GA+VN T GY
Sbjct: 704 QEDKVNVADILTKHGADQDAHTKL-GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY 762
Query: 252 SP 253
+P
Sbjct: 763 TP 764
Score = 76.6 bits (187), Expect = 3e-14
Identities = 57/196 (29%), Positives = 96/196 (48%), Gaps = 11/196 (5%)
Query: 74 GDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGA 133
G++ LH+A +A +EV+R + + A ++ + +QTPLH+A + EI + LL
Sbjct: 464 GETALHMAA----RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 134 GCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIH 193
P+ G TPLH++ +G + VL ++ HS+ G T LH+A+ +
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA---HSL---ATKKGFTPLHVAAKY 573
Query: 194 GYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSP 253
G L + +LL+ A ++ NG T LH+A N + LLL+ GA + GY+P
Sbjct: 574 GSLDVAKLLLQRRAAADSAGK-NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTP 632
Query: 254 YQLTWGRPSTRIQQQL 269
+ + +I L
Sbjct: 633 LHIAAKKNQMQIASTL 648
Score = 73.2 bits (178), Expect = 3e-13
Identities = 50/144 (34%), Positives = 70/144 (48%), Gaps = 7/144 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TPLH++ Q ++A LL AG L +G TPLH+A + G L +L Q
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR------ 585
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
+ + NG T LH+A+ + + LL+ GA +A NG T LH+A +
Sbjct: 586 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK-NGYTPLHIAAKKNQMQI 644
Query: 233 VSLLLKCGADVNRVTYQGYSPYQL 256
S LL GA+ N VT QG +P L
Sbjct: 645 ASTLLNYGAETNIVTKQGVTPLHL 668
Score = 69.3 bits (168), Expect = 4e-12
Identities = 48/145 (33%), Positives = 76/145 (52%), Gaps = 7/145 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TPLH+A N+ ++ E L+ G + G TP+H+A G L V +L Q+ +P +
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
TN G T LH+A+ G + +V L+ GA V+A+ +T LH+A L ++
Sbjct: 460 ------TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAR-EEQTPLHIASRLGKTEI 512
Query: 233 VSLLLKCGADVNRVTYQGYSPYQLT 257
V LLL+ A + T GY+P ++
Sbjct: 513 VQLLLQHMAHPDAATTNGYTPLHIS 537
Score = 68.2 bits (165), Expect = 9e-12
Identities = 68/255 (26%), Positives = 116/255 (45%), Gaps = 44/255 (17%)
Query: 30 HDSGLDSMKDEEYEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKAL 89
+ +GL+++ E V +QE+ + RGS T+ G++ LH+A + A
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQEL------LGRGSSV--DSATKKGNTALHIASL----AG 108
Query: 90 TMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLH 149
EV++ + + A +N Q+ TPL++A N ++ + LL G + G TPL
Sbjct: 109 QAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 168
Query: 150 LACEQGCLASVGVLTQSCT-----TPHLH--------------------------SILKA 178
+A +QG +V +L ++ T P LH ++
Sbjct: 169 VALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNR 228
Query: 179 TNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLK 238
T +G T LH+A+ +G + + LL++ GA V+ NG T LH+A N ++V LLL
Sbjct: 229 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTAR-NGITPLHVASKRGNTNMVKLLLD 287
Query: 239 CGADVNRVTYQGYSP 253
G ++ T G +P
Sbjct: 288 RGGQIDAKTRDGLTP 302
Score = 63.2 bits (152), Expect = 3e-10
Identities = 45/141 (31%), Positives = 70/141 (49%), Gaps = 7/141 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TP+H+A I LL G P++ + RG T LH+A G + V L ++
Sbjct: 433 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN------ 486
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
+++ A T LH+AS G IV+LL+ A +A NG T LH++ D+
Sbjct: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA-ATTNGYTPLHISAREGQVDV 545
Query: 233 VSLLLKCGADVNRVTYQGYSP 253
S+LL+ GA + T +G++P
Sbjct: 546 ASVLLEAGAAHSLATKKGFTP 566
Score = 58.2 bits (139), Expect = 1e-08
Identities = 44/141 (31%), Positives = 68/141 (48%), Gaps = 7/141 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TPLH A + ++ E LL G R G +PLH+A + + V L Q H
Sbjct: 301 TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ-----HK 355
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
+ T + T LH+A+ G+ + +LL+ A+ NA+ NG T LH+A +
Sbjct: 356 APVDDVT-LDYLTALHVAAHCGHYRVTKLLLDKRANPNAR-ALNGFTPLHIACKKNRIKV 413
Query: 233 VSLLLKCGADVNRVTYQGYSP 253
+ LL+K GA + +T G +P
Sbjct: 414 MELLVKYGASIQAITESGLTP 434
Score = 52.8 bits (125), Expect = 4e-07
Identities = 27/78 (34%), Positives = 47/78 (60%), Gaps = 1/78 (1%)
Query: 176 LKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSL 235
+ N NG LHLA+ G++G+V+ L+ G+ V++ G TALH+A ++V +
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK-KGNTALHIASLAGQAEVVKV 115
Query: 236 LLKCGADVNRVTYQGYSP 253
L+K GA++N + G++P
Sbjct: 116 LVKEGANINAQSQNGFTP 133
Score = 51.2 bits (121), Expect = 1e-06
Identities = 40/132 (30%), Positives = 61/132 (46%), Gaps = 10/132 (7%)
Query: 71 TEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEAL 130
T+ G + LHLA E+K +++ + D + L TPL +A ++ L
Sbjct: 692 TKSGLTSLHLAA-QEDKVNVADILTKHGADQ---DAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 131 LGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLA 190
L G + + G TPLH A +QG + VL Q P+ AT NG+T L +A
Sbjct: 748 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN------ATTANGNTALAIA 801
Query: 191 SIHGYLGIVELL 202
GY+ +V+ L
Sbjct: 802 KRLGYISVVDTL 813
Score = 50.8 bits (120), Expect = 2e-06
Identities = 43/162 (26%), Positives = 68/162 (41%), Gaps = 41/162 (25%)
Query: 92 EVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLA 151
+V+ +KG + +N N LHLA + + LLG G + +GNT LH
Sbjct: 46 KVVEYLKGGID-INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH-- 102
Query: 152 CEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNA 211
+AS+ G +V++LV GA++NA
Sbjct: 103 -------------------------------------IASLAGQAEVVKVLVKEGANINA 125
Query: 212 QEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSP 253
Q NG T L++A + D+V LL+ GA+ + T G++P
Sbjct: 126 QSQ-NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 79.0 bits (193), Expect = 5e-15
Identities = 58/182 (31%), Positives = 92/182 (50%), Gaps = 11/182 (6%)
Query: 72 EDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALL 131
++G + LH+A ++ + + + ++ KG +N TPLH+A NQ +IA LL
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLE--KGASPHATAKNGY--TPLHIAAKKNQMQIASTLL 649
Query: 132 GAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLAS 191
G + + +G TPLHLA ++G V +L H+ + +G T LHLA+
Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM------STKSGLTSLHLAA 703
Query: 192 IHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGY 251
+ + ++L GAD +A G T L +A N +V+ LLK GA+VN T GY
Sbjct: 704 QEDKVNVADILTKHGADQDAHTKL-GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY 762
Query: 252 SP 253
+P
Sbjct: 763 TP 764
Score = 76.6 bits (187), Expect = 3e-14
Identities = 57/196 (29%), Positives = 96/196 (48%), Gaps = 11/196 (5%)
Query: 74 GDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGA 133
G++ LH+A +A +EV+R + + A ++ + +QTPLH+A + EI + LL
Sbjct: 464 GETALHMAA----RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 134 GCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIH 193
P+ G TPLH++ +G + VL ++ HS+ G T LH+A+ +
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA---HSL---ATKKGFTPLHVAAKY 573
Query: 194 GYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSP 253
G L + +LL+ A ++ NG T LH+A N + LLL+ GA + GY+P
Sbjct: 574 GSLDVAKLLLQRRAAADSAGK-NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTP 632
Query: 254 YQLTWGRPSTRIQQQL 269
+ + +I L
Sbjct: 633 LHIAAKKNQMQIASTL 648
Score = 73.2 bits (178), Expect = 3e-13
Identities = 50/144 (34%), Positives = 70/144 (48%), Gaps = 7/144 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TPLH++ Q ++A LL AG L +G TPLH+A + G L +L Q
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR------ 585
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
+ + NG T LH+A+ + + LL+ GA +A NG T LH+A +
Sbjct: 586 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK-NGYTPLHIAAKKNQMQI 644
Query: 233 VSLLLKCGADVNRVTYQGYSPYQL 256
S LL GA+ N VT QG +P L
Sbjct: 645 ASTLLNYGAETNIVTKQGVTPLHL 668
Score = 69.3 bits (168), Expect = 4e-12
Identities = 48/145 (33%), Positives = 76/145 (52%), Gaps = 7/145 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TPLH+A N+ ++ E L+ G + G TP+H+A G L V +L Q+ +P +
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
TN G T LH+A+ G + +V L+ GA V+A+ +T LH+A L ++
Sbjct: 460 ------TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAR-EEQTPLHIASRLGKTEI 512
Query: 233 VSLLLKCGADVNRVTYQGYSPYQLT 257
V LLL+ A + T GY+P ++
Sbjct: 513 VQLLLQHMAHPDAATTNGYTPLHIS 537
Score = 68.2 bits (165), Expect = 9e-12
Identities = 68/255 (26%), Positives = 116/255 (45%), Gaps = 44/255 (17%)
Query: 30 HDSGLDSMKDEEYEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKAL 89
+ +GL+++ E V +QE+ + RGS T+ G++ LH+A + A
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQEL------LGRGSSV--DSATKKGNTALHIASL----AG 108
Query: 90 TMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLH 149
EV++ + + A +N Q+ TPL++A N ++ + LL G + G TPL
Sbjct: 109 QAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 168
Query: 150 LACEQGCLASVGVLTQSCT-----TPHLH--------------------------SILKA 178
+A +QG +V +L ++ T P LH ++
Sbjct: 169 VALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNR 228
Query: 179 TNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLK 238
T +G T LH+A+ +G + + LL++ GA V+ NG T LH+A N ++V LLL
Sbjct: 229 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTAR-NGITPLHVASKRGNTNMVKLLLD 287
Query: 239 CGADVNRVTYQGYSP 253
G ++ T G +P
Sbjct: 288 RGGQIDAKTRDGLTP 302
Score = 63.2 bits (152), Expect = 3e-10
Identities = 45/141 (31%), Positives = 70/141 (49%), Gaps = 7/141 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TP+H+A I LL G P++ + RG T LH+A G + V L ++
Sbjct: 433 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN------ 486
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
+++ A T LH+AS G IV+LL+ A +A NG T LH++ D+
Sbjct: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA-ATTNGYTPLHISAREGQVDV 545
Query: 233 VSLLLKCGADVNRVTYQGYSP 253
S+LL+ GA + T +G++P
Sbjct: 546 ASVLLEAGAAHSLATKKGFTP 566
Score = 58.2 bits (139), Expect = 1e-08
Identities = 44/141 (31%), Positives = 68/141 (48%), Gaps = 7/141 (4%)
Query: 113 TPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL 172
TPLH A + ++ E LL G R G +PLH+A + + V L Q H
Sbjct: 301 TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ-----HK 355
Query: 173 HSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDL 232
+ T + T LH+A+ G+ + +LL+ A+ NA+ NG T LH+A +
Sbjct: 356 APVDDVT-LDYLTALHVAAHCGHYRVTKLLLDKRANPNAR-ALNGFTPLHIACKKNRIKV 413
Query: 233 VSLLLKCGADVNRVTYQGYSP 253
+ LL+K GA + +T G +P
Sbjct: 414 MELLVKYGASIQAITESGLTP 434
Score = 52.8 bits (125), Expect = 4e-07
Identities = 27/78 (34%), Positives = 47/78 (60%), Gaps = 1/78 (1%)
Query: 176 LKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSL 235
+ N NG LHLA+ G++G+V+ L+ G+ V++ G TALH+A ++V +
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK-KGNTALHIASLAGQAEVVKV 115
Query: 236 LLKCGADVNRVTYQGYSP 253
L+K GA++N + G++P
Sbjct: 116 LVKEGANINAQSQNGFTP 133
Score = 51.2 bits (121), Expect = 1e-06
Identities = 40/132 (30%), Positives = 61/132 (46%), Gaps = 10/132 (7%)
Query: 71 TEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEAL 130
T+ G + LHLA E+K +++ + D + L TPL +A ++ L
Sbjct: 692 TKSGLTSLHLAA-QEDKVNVADILTKHGADQ---DAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 131 LGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLA 190
L G + + G TPLH A +QG + VL Q P+ AT NG+T L +A
Sbjct: 748 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN------ATTANGNTALAIA 801
Query: 191 SIHGYLGIVELL 202
GY+ +V+ L
Sbjct: 802 KRLGYISVVDTL 813
Score = 50.8 bits (120), Expect = 2e-06
Identities = 43/162 (26%), Positives = 68/162 (41%), Gaps = 41/162 (25%)
Query: 92 EVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLA 151
+V+ +KG + +N N LHLA + + LLG G + +GNT LH
Sbjct: 46 KVVEYLKGGID-INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH-- 102
Query: 152 CEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNA 211
+AS+ G +V++LV GA++NA
Sbjct: 103 -------------------------------------IASLAGQAEVVKVLVKEGANINA 125
Query: 212 QEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSP 253
Q NG T L++A + D+V LL+ GA+ + T G++P
Sbjct: 126 QSQ-NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166
>gi|140161500 ankyrin repeat and sterile alpha motif domain
containing 1 [Homo sapiens]
Length = 1134
Score = 78.6 bits (192), Expect = 7e-15
Identities = 62/190 (32%), Positives = 87/190 (45%), Gaps = 9/190 (4%)
Query: 78 LHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDP 137
LHLA + + +I Q +N QNN +T LH A E+ + LL DP
Sbjct: 117 LHLAAWKGDAQIVRLLIHQGPSHTR-VNEQNNDNETALHCAAQYGHTEVVKVLLEELTDP 175
Query: 138 ELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLG 197
+R+ + TPL LA G L V +L + H L + N HT LHLA+ +G+
Sbjct: 176 TMRNNKFETPLDLAALYGRLEVVKMLLNA------HPNLLSCNTKKHTPLHLAARNGHKA 229
Query: 198 IVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLT 257
+V++L+ G D N Q +ALH A D+V +LL G DVN G +
Sbjct: 230 VVQVLLDAGMDSNYQTEMG--SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTV 287
Query: 258 WGRPSTRIQQ 267
PS + QQ
Sbjct: 288 RELPSQKSQQ 297
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 78.6 bits (192), Expect = 7e-15
Identities = 60/183 (32%), Positives = 90/183 (49%), Gaps = 11/183 (6%)
Query: 69 QLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAE 128
+L +G S HLA K LT E + + + A +N +N T LHLA I+ QP+ +
Sbjct: 49 KLDSNGQSPFHLAA---SKGLT-ECLTILLANGADINSKNEDGSTALHLATISCQPQCVK 104
Query: 129 ALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLH 188
LL G + + D +PLH A GC +SV +L + L + +G T L
Sbjct: 105 VLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDH------EAFLDVLDNDGRTPLM 158
Query: 189 LASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTY 248
+AS+ G+ I L+ GA VN + N ++AL LA + + ++ LLL GAD V
Sbjct: 159 IASLGGHAAICSQLLQRGARVNVTDK-NDKSALILACEKGSAEVAELLLSHGADAGAVDS 217
Query: 249 QGY 251
G+
Sbjct: 218 TGH 220
Score = 47.4 bits (111), Expect = 2e-05
Identities = 30/81 (37%), Positives = 45/81 (55%), Gaps = 3/81 (3%)
Query: 182 NGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGA 241
NG + HLA+ G + +L++ GAD+N++ +G TALHLA P V +LL+ GA
Sbjct: 53 NGQSPFHLAASKGLTECLTILLANGADINSKNE-DGSTALHLATISCQPQCVKVLLQHGA 111
Query: 242 DVNRVTYQGYSPYQLTWGRPS 262
+ + V + SP L W S
Sbjct: 112 NEDAVDAENRSP--LHWAASS 130
Score = 30.8 bits (68), Expect = 1.7
Identities = 22/77 (28%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 181 YNGHTCLHLASIH-GYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKC 239
+N H L ++H G +G V L S + + NG++ HLA + +++LL
Sbjct: 17 WNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLAN 76
Query: 240 GADVNRVTYQGYSPYQL 256
GAD+N G + L
Sbjct: 77 GADINSKNEDGSTALHL 93
Score = 29.6 bits (65), Expect = 3.7
Identities = 24/88 (27%), Positives = 40/88 (45%), Gaps = 4/88 (4%)
Query: 64 EPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQ 123
E + L DG + L +A + A+ +++++ A +N + ++ L LA
Sbjct: 143 EAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRG----ARVNVTDKNDKSALILACEKGS 198
Query: 124 PEIAEALLGAGCDPELRDFRGNTPLHLA 151
E+AE LL G D D G+ LH A
Sbjct: 199 AEVAELLLSHGADAGAVDSTGHDALHYA 226
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 76.3 bits (186), Expect = 3e-14
Identities = 52/146 (35%), Positives = 76/146 (52%), Gaps = 7/146 (4%)
Query: 107 QNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQS 166
Q+ + LHLA + E LL + C E D G T LH A QGCL +V +L +
Sbjct: 85 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 144
Query: 167 CTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVD 226
S + + +G+ L LA +G+ I L+ GADVN++ +GRTAL LA +
Sbjct: 145 ------KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK-SGRTALMLACE 197
Query: 227 LQNPDLVSLLLKCGADVNRVTYQGYS 252
+ + + V L+K GAD+N V GY+
Sbjct: 198 IGSSNAVEALIKKGADLNLVDSLGYN 223
Score = 39.3 bits (90), Expect = 0.005
Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 3/62 (4%)
Query: 183 GHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLL--KCG 240
G T HLA+ G++ + ++++ G DV AQ+ G +ALHLA + + + LL KC
Sbjct: 56 GKTAFHLAAAKGHVECLRVMITHGVDVTAQD-TTGHSALHLAAKNSHHECIRKLLQSKCP 114
Query: 241 AD 242
A+
Sbjct: 115 AE 116
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 76.3 bits (186), Expect = 3e-14
Identities = 52/146 (35%), Positives = 76/146 (52%), Gaps = 7/146 (4%)
Query: 107 QNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQS 166
Q+ + LHLA + E LL + C E D G T LH A QGCL +V +L +
Sbjct: 74 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 133
Query: 167 CTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVD 226
S + + +G+ L LA +G+ I L+ GADVN++ +GRTAL LA +
Sbjct: 134 ------KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK-SGRTALMLACE 186
Query: 227 LQNPDLVSLLLKCGADVNRVTYQGYS 252
+ + + V L+K GAD+N V GY+
Sbjct: 187 IGSSNAVEALIKKGADLNLVDSLGYN 212
Score = 39.3 bits (90), Expect = 0.005
Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 3/62 (4%)
Query: 183 GHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLL--KCG 240
G T HLA+ G++ + ++++ G DV AQ+ G +ALHLA + + + LL KC
Sbjct: 45 GKTAFHLAAAKGHVECLRVMITHGVDVTAQD-TTGHSALHLAAKNSHHECIRKLLQSKCP 103
Query: 241 AD 242
A+
Sbjct: 104 AE 105
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 76.3 bits (186), Expect = 3e-14
Identities = 52/146 (35%), Positives = 76/146 (52%), Gaps = 7/146 (4%)
Query: 107 QNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQS 166
Q+ + LHLA + E LL + C E D G T LH A QGCL +V +L +
Sbjct: 82 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
Query: 167 CTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVD 226
S + + +G+ L LA +G+ I L+ GADVN++ +GRTAL LA +
Sbjct: 142 ------KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK-SGRTALMLACE 194
Query: 227 LQNPDLVSLLLKCGADVNRVTYQGYS 252
+ + + V L+K GAD+N V GY+
Sbjct: 195 IGSSNAVEALIKKGADLNLVDSLGYN 220
Score = 39.3 bits (90), Expect = 0.005
Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 3/62 (4%)
Query: 183 GHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLL--KCG 240
G T HLA+ G++ + ++++ G DV AQ+ G +ALHLA + + + LL KC
Sbjct: 53 GKTAFHLAAAKGHVECLRVMITHGVDVTAQD-TTGHSALHLAAKNSHHECIRKLLQSKCP 111
Query: 241 AD 242
A+
Sbjct: 112 AE 113
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 76.3 bits (186), Expect = 3e-14
Identities = 52/146 (35%), Positives = 76/146 (52%), Gaps = 7/146 (4%)
Query: 107 QNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQS 166
Q+ + LHLA + E LL + C E D G T LH A QGCL +V +L +
Sbjct: 82 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
Query: 167 CTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVD 226
S + + +G+ L LA +G+ I L+ GADVN++ +GRTAL LA +
Sbjct: 142 ------KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK-SGRTALMLACE 194
Query: 227 LQNPDLVSLLLKCGADVNRVTYQGYS 252
+ + + V L+K GAD+N V GY+
Sbjct: 195 IGSSNAVEALIKKGADLNLVDSLGYN 220
Score = 39.3 bits (90), Expect = 0.005
Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 3/62 (4%)
Query: 183 GHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLL--KCG 240
G T HLA+ G++ + ++++ G DV AQ+ G +ALHLA + + + LL KC
Sbjct: 53 GKTAFHLAAAKGHVECLRVMITHGVDVTAQD-TTGHSALHLAAKNSHHECIRKLLQSKCP 111
Query: 241 AD 242
A+
Sbjct: 112 AE 113
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 76.3 bits (186), Expect = 3e-14
Identities = 52/146 (35%), Positives = 76/146 (52%), Gaps = 7/146 (4%)
Query: 107 QNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQS 166
Q+ + LHLA + E LL + C E D G T LH A QGCL +V +L +
Sbjct: 82 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
Query: 167 CTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVD 226
S + + +G+ L LA +G+ I L+ GADVN++ +GRTAL LA +
Sbjct: 142 ------KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK-SGRTALMLACE 194
Query: 227 LQNPDLVSLLLKCGADVNRVTYQGYS 252
+ + + V L+K GAD+N V GY+
Sbjct: 195 IGSSNAVEALIKKGADLNLVDSLGYN 220
Score = 39.3 bits (90), Expect = 0.005
Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 3/62 (4%)
Query: 183 GHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLL--KCG 240
G T HLA+ G++ + ++++ G DV AQ+ G +ALHLA + + + LL KC
Sbjct: 53 GKTAFHLAAAKGHVECLRVMITHGVDVTAQD-TTGHSALHLAAKNSHHECIRKLLQSKCP 111
Query: 241 AD 242
A+
Sbjct: 112 AE 113
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 76.3 bits (186), Expect = 3e-14
Identities = 52/146 (35%), Positives = 76/146 (52%), Gaps = 7/146 (4%)
Query: 107 QNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQS 166
Q+ + LHLA + E LL + C E D G T LH A QGCL +V +L +
Sbjct: 82 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
Query: 167 CTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVD 226
S + + +G+ L LA +G+ I L+ GADVN++ +GRTAL LA +
Sbjct: 142 ------KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK-SGRTALMLACE 194
Query: 227 LQNPDLVSLLLKCGADVNRVTYQGYS 252
+ + + V L+K GAD+N V GY+
Sbjct: 195 IGSSNAVEALIKKGADLNLVDSLGYN 220
Score = 39.3 bits (90), Expect = 0.005
Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 3/62 (4%)
Query: 183 GHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLL--KCG 240
G T HLA+ G++ + ++++ G DV AQ+ G +ALHLA + + + LL KC
Sbjct: 53 GKTAFHLAAAKGHVECLRVMITHGVDVTAQD-TTGHSALHLAAKNSHHECIRKLLQSKCP 111
Query: 241 AD 242
A+
Sbjct: 112 AE 113
>gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]
Length = 319
Score = 76.3 bits (186), Expect = 3e-14
Identities = 71/248 (28%), Positives = 115/248 (46%), Gaps = 14/248 (5%)
Query: 9 QEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVPRGSEPWKQ 68
Q+W E R+ K++ L+ R S L++++D E +K+ ++ R +VP EP +
Sbjct: 58 QQWKSEKQREAELKKKKLEQR--SKLENLEDLEIIIQLKKRKKYR--KTKVPVVKEPEPE 113
Query: 69 QLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAE 128
+TE D L E K + V+ + D + + ++T LH A + I E
Sbjct: 114 IITEPVDVPTFLKAALENK---LPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVE 170
Query: 129 ALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLH 188
L+ AG E RD +T +H A G L + +L + + A + T LH
Sbjct: 171 KLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNK------GAKISARDKLLSTALH 224
Query: 189 LASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTY 248
+A G+ E L++ AD+NA++ G T LH AV L ++ LL+ GAD+N
Sbjct: 225 VAVRTGHYECAEHLIACEADLNAKDR-EGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNC 283
Query: 249 QGYSPYQL 256
G +P L
Sbjct: 284 AGKTPMDL 291
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,034,731
Number of Sequences: 37866
Number of extensions: 604988
Number of successful extensions: 5780
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 337
Number of HSP's successfully gapped in prelim test: 46
Number of HSP's that attempted gapping in prelim test: 2340
Number of HSP's gapped (non-prelim): 1656
length of query: 317
length of database: 18,247,518
effective HSP length: 102
effective length of query: 215
effective length of database: 14,385,186
effective search space: 3092814990
effective search space used: 3092814990
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.