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Search of human proteins with 186659512
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|186659512 calmodulin regulated spectrin-associated protein 1
[Homo sapiens]
(1602 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|186659512 calmodulin regulated spectrin-associated protein 1 ... 3184 0.0
gi|44955929 calmodulin regulated spectrin-associated protein 1-l... 561 e-159
gi|130502140 NEZHA isoform 2 [Homo sapiens] 367 e-101
gi|122937255 NEZHA isoform 1 [Homo sapiens] 367 e-101
gi|4505101 microtubule-associated protein 7 [Homo sapiens] 59 4e-08
gi|221219024 pleckstrin homology-like domain, family B, member 1... 54 1e-06
gi|38424073 pleckstrin homology-like domain, family B, member 1 ... 54 1e-06
gi|13027602 DDRGK domain containing 1 [Homo sapiens] 54 1e-06
gi|148746195 trichohyalin [Homo sapiens] 52 4e-06
gi|134152708 arginine and glutamate rich 1 [Homo sapiens] 52 4e-06
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 52 5e-06
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 51 1e-05
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 51 1e-05
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 51 1e-05
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 51 1e-05
gi|15826852 acyl-Coenzyme A binding domain containing 3 [Homo sa... 51 1e-05
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi... 50 2e-05
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 50 2e-05
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 50 2e-05
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 50 2e-05
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 49 3e-05
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 49 5e-05
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 49 5e-05
gi|22758136 MAP7 domain containing 2 [Homo sapiens] 49 5e-05
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 48 7e-05
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 48 7e-05
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 48 7e-05
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 48 7e-05
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 48 7e-05
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 48 7e-05
>gi|186659512 calmodulin regulated spectrin-associated protein 1 [Homo
sapiens]
Length = 1602
Score = 3184 bits (8256), Expect = 0.0
Identities = 1602/1602 (100%), Positives = 1602/1602 (100%)
Query: 1 MVDASGRAAAEGWRKMEAPPDGAADLVPLDRYDAARAKIAANLQWICAKAYGRDNIPEDL 60
MVDASGRAAAEGWRKMEAPPDGAADLVPLDRYDAARAKIAANLQWICAKAYGRDNIPEDL
Sbjct: 1 MVDASGRAAAEGWRKMEAPPDGAADLVPLDRYDAARAKIAANLQWICAKAYGRDNIPEDL 60
Query: 61 RDPFYVDQYEQEHIKPPVIKLLLSSELYCRVCSLILKGDQVAALQGHQSVIQALSRKGIY 120
RDPFYVDQYEQEHIKPPVIKLLLSSELYCRVCSLILKGDQVAALQGHQSVIQALSRKGIY
Sbjct: 61 RDPFYVDQYEQEHIKPPVIKLLLSSELYCRVCSLILKGDQVAALQGHQSVIQALSRKGIY 120
Query: 121 VMESDDTPVTESDLSRAPIKMSAHMAMVDALMMAYTVEMISIEKVVASVKRFSTFSASKE 180
VMESDDTPVTESDLSRAPIKMSAHMAMVDALMMAYTVEMISIEKVVASVKRFSTFSASKE
Sbjct: 121 VMESDDTPVTESDLSRAPIKMSAHMAMVDALMMAYTVEMISIEKVVASVKRFSTFSASKE 180
Query: 181 LPYDLEDAMVFWINKVNLKMREITEKEVKLKQQLLESPAHQKVRYRREHLSARQSPYFPL 240
LPYDLEDAMVFWINKVNLKMREITEKEVKLKQQLLESPAHQKVRYRREHLSARQSPYFPL
Sbjct: 181 LPYDLEDAMVFWINKVNLKMREITEKEVKLKQQLLESPAHQKVRYRREHLSARQSPYFPL 240
Query: 241 LEDLMRDGSDGAALLAVIHYYCPEQMKLDDICLKEVTSMADSLYNIRLLREFSNEYLNKC 300
LEDLMRDGSDGAALLAVIHYYCPEQMKLDDICLKEVTSMADSLYNIRLLREFSNEYLNKC
Sbjct: 241 LEDLMRDGSDGAALLAVIHYYCPEQMKLDDICLKEVTSMADSLYNIRLLREFSNEYLNKC 300
Query: 301 FYLTLEDMLYAPLVLKPNVMVFIAELFWWFENVKPDFVQPRDVQELKDAKTVLHQKSSRP 360
FYLTLEDMLYAPLVLKPNVMVFIAELFWWFENVKPDFVQPRDVQELKDAKTVLHQKSSRP
Sbjct: 301 FYLTLEDMLYAPLVLKPNVMVFIAELFWWFENVKPDFVQPRDVQELKDAKTVLHQKSSRP 360
Query: 361 PVPISNATKRSFLGSPAAGTLAELQPPVQLPAEGCHRHYLHPEEPEYLGKGTAAFSPSHP 420
PVPISNATKRSFLGSPAAGTLAELQPPVQLPAEGCHRHYLHPEEPEYLGKGTAAFSPSHP
Sbjct: 361 PVPISNATKRSFLGSPAAGTLAELQPPVQLPAEGCHRHYLHPEEPEYLGKGTAAFSPSHP 420
Query: 421 LLPLRQKQQKSIQGEDIPDQRHRSNSLTRVDGQPRGAAIAWPEKKTRPASQPTPFALHHA 480
LLPLRQKQQKSIQGEDIPDQRHRSNSLTRVDGQPRGAAIAWPEKKTRPASQPTPFALHHA
Sbjct: 421 LLPLRQKQQKSIQGEDIPDQRHRSNSLTRVDGQPRGAAIAWPEKKTRPASQPTPFALHHA 480
Query: 481 ASCEVDPSSGDSISLARSISKDSLASNIVNLTPQNQPHPTATKSHGKSLLSNVSIEDEEE 540
ASCEVDPSSGDSISLARSISKDSLASNIVNLTPQNQPHPTATKSHGKSLLSNVSIEDEEE
Sbjct: 481 ASCEVDPSSGDSISLARSISKDSLASNIVNLTPQNQPHPTATKSHGKSLLSNVSIEDEEE 540
Query: 541 ELVAIVRADVVPQQADPEFPRASPRALGLTANARSPQGQLDTSESKPDSFFLEPLMPAVL 600
ELVAIVRADVVPQQADPEFPRASPRALGLTANARSPQGQLDTSESKPDSFFLEPLMPAVL
Sbjct: 541 ELVAIVRADVVPQQADPEFPRASPRALGLTANARSPQGQLDTSESKPDSFFLEPLMPAVL 600
Query: 601 KPAKEKQVITKEDERGEGRPRSIVSRRPSEGPQPLVRRKMTGSRDLNRTFTPIPCSEFPM 660
KPAKEKQVITKEDERGEGRPRSIVSRRPSEGPQPLVRRKMTGSRDLNRTFTPIPCSEFPM
Sbjct: 601 KPAKEKQVITKEDERGEGRPRSIVSRRPSEGPQPLVRRKMTGSRDLNRTFTPIPCSEFPM 660
Query: 661 GIDPTETGPLSVETAGEVCGGPLALGGFDPFPQGPSTDGFFLHVGRADEDTEGRLYVSCS 720
GIDPTETGPLSVETAGEVCGGPLALGGFDPFPQGPSTDGFFLHVGRADEDTEGRLYVSCS
Sbjct: 661 GIDPTETGPLSVETAGEVCGGPLALGGFDPFPQGPSTDGFFLHVGRADEDTEGRLYVSCS 720
Query: 721 KSPNSHDSEPWTLLRQDSDSDVVDIEEAEHDFMGEAHPVVFSRYIGEEESAKLQEDMKVK 780
KSPNSHDSEPWTLLRQDSDSDVVDIEEAEHDFMGEAHPVVFSRYIGEEESAKLQEDMKVK
Sbjct: 721 KSPNSHDSEPWTLLRQDSDSDVVDIEEAEHDFMGEAHPVVFSRYIGEEESAKLQEDMKVK 780
Query: 781 EHEDKDDASGRSSPCLSTASQMSSVSMASGSVKMTSFAERKLQRLNSCETKSSTSSSQKT 840
EHEDKDDASGRSSPCLSTASQMSSVSMASGSVKMTSFAERKLQRLNSCETKSSTSSSQKT
Sbjct: 781 EHEDKDDASGRSSPCLSTASQMSSVSMASGSVKMTSFAERKLQRLNSCETKSSTSSSQKT 840
Query: 841 TPDASESCPAPLTTWRQKREQSPSQHGKDPASLLASELVQLHMQLEEKRRAIEAQKKKME 900
TPDASESCPAPLTTWRQKREQSPSQHGKDPASLLASELVQLHMQLEEKRRAIEAQKKKME
Sbjct: 841 TPDASESCPAPLTTWRQKREQSPSQHGKDPASLLASELVQLHMQLEEKRRAIEAQKKKME 900
Query: 901 ALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPEHFAKEYSQHNGEDCGDAVSKTEDFLVK 960
ALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPEHFAKEYSQHNGEDCGDAVSKTEDFLVK
Sbjct: 901 ALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPEHFAKEYSQHNGEDCGDAVSKTEDFLVK 960
Query: 961 EEQREELLHEPQDVDKESLAFAQQHKAKDPVALHELERNKVISAALLEDTVGEVVDVNEC 1020
EEQREELLHEPQDVDKESLAFAQQHKAKDPVALHELERNKVISAALLEDTVGEVVDVNEC
Sbjct: 961 EEQREELLHEPQDVDKESLAFAQQHKAKDPVALHELERNKVISAALLEDTVGEVVDVNEC 1020
Query: 1021 DLSIEKLNETISTLQQAILKISQQQEQLLMKSPTVPVPGSKNNSQDHKVKAPVHFVEPLS 1080
DLSIEKLNETISTLQQAILKISQQQEQLLMKSPTVPVPGSKNNSQDHKVKAPVHFVEPLS
Sbjct: 1021 DLSIEKLNETISTLQQAILKISQQQEQLLMKSPTVPVPGSKNNSQDHKVKAPVHFVEPLS 1080
Query: 1081 PTGVAGHRKAPRLGQGRNSRSGRPAELKVPKDRPQGSSRSKTPTPSVETLPHLRPFPASS 1140
PTGVAGHRKAPRLGQGRNSRSGRPAELKVPKDRPQGSSRSKTPTPSVETLPHLRPFPASS
Sbjct: 1081 PTGVAGHRKAPRLGQGRNSRSGRPAELKVPKDRPQGSSRSKTPTPSVETLPHLRPFPASS 1140
Query: 1141 HPRTPTDPGLDSALEPSGDPHGKCLFDSYRLHDESNQRTLTLSSSKDANILSEQMSLKEV 1200
HPRTPTDPGLDSALEPSGDPHGKCLFDSYRLHDESNQRTLTLSSSKDANILSEQMSLKEV
Sbjct: 1141 HPRTPTDPGLDSALEPSGDPHGKCLFDSYRLHDESNQRTLTLSSSKDANILSEQMSLKEV 1200
Query: 1201 LDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLV 1260
LDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLV
Sbjct: 1201 LDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLV 1260
Query: 1261 SEGDQKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEAR 1320
SEGDQKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEAR
Sbjct: 1261 SEGDQKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEAR 1320
Query: 1321 RKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREESCS 1380
RKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREESCS
Sbjct: 1321 RKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREESCS 1380
Query: 1381 DSGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVESMEALPILSRNPSR 1440
DSGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVESMEALPILSRNPSR
Sbjct: 1381 DSGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVESMEALPILSRNPSR 1440
Query: 1441 STDRDWETASAASSLASVAEYTGPKLFKEPSSKSNKPIIHNAISHCCLAGKVNEPHKNSI 1500
STDRDWETASAASSLASVAEYTGPKLFKEPSSKSNKPIIHNAISHCCLAGKVNEPHKNSI
Sbjct: 1441 STDRDWETASAASSLASVAEYTGPKLFKEPSSKSNKPIIHNAISHCCLAGKVNEPHKNSI 1500
Query: 1501 LEELEKCDANHYIILFRDAGCQFRALYCYYPDTEEIYKLTGTGPKNITKKMIDKLYKYSS 1560
LEELEKCDANHYIILFRDAGCQFRALYCYYPDTEEIYKLTGTGPKNITKKMIDKLYKYSS
Sbjct: 1501 LEELEKCDANHYIILFRDAGCQFRALYCYYPDTEEIYKLTGTGPKNITKKMIDKLYKYSS 1560
Query: 1561 DRKQFNLIPAKTMSVSVDALTIHNHLWQPKRPAVPKKAQTRK 1602
DRKQFNLIPAKTMSVSVDALTIHNHLWQPKRPAVPKKAQTRK
Sbjct: 1561 DRKQFNLIPAKTMSVSVDALTIHNHLWQPKRPAVPKKAQTRK 1602
>gi|44955929 calmodulin regulated spectrin-associated protein 1-like 1
[Homo sapiens]
Length = 1478
Score = 561 bits (1445), Expect = e-159
Identities = 387/921 (42%), Positives = 520/921 (56%), Gaps = 89/921 (9%)
Query: 734 LRQDSDSDVVDIEEAEHDFMGEAHPVVFSRYIGEEESAKLQEDMKVKEH-----EDKDDA 788
L Q S +V D + A E+ + ED ++++ D DDA
Sbjct: 584 LNQSSPDNVTDTKGALSPITDNTEVDTGIHVPSEDIPETMDEDSSLRDYTVSLDSDMDDA 643
Query: 789 S----------GRS----SPC---LSTASQMSSVSMASGSVKMTSFAERKLQRLNSCETK 831
S G + SPC +ST SQ S + +S VKMTSFAE+K ++LN + K
Sbjct: 644 SKFLQDYDIRTGNTREALSPCPSTVSTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGK 703
Query: 832 SSTSSSQKTTPDASESCPAPLTTWRQKREQSPSQHGKDPASLLASELVQLHMQLEEKRRA 891
SS SSSQKTTP+ SE + W Q E++ G+D LLASE+V L M+LEEKRRA
Sbjct: 704 SSGSSSQKTTPEGSELNIPHVVAWAQIPEETGLPQGRDTTQLLASEMVHLRMKLEEKRRA 763
Query: 892 IEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPEHFAKEYSQHNGEDCGDAV 951
IEAQKKKMEA +QR K+G+ AFL VVKK K + PLR E E D
Sbjct: 764 IEAQKKKMEAAFTKQRQKMGRTAFLTVVKK-KGDGISPLREEAAGAE----------DEK 812
Query: 952 SKTEDFLVKEEQREELLHEPQDVD-KESLAFAQQHKAKDPVALHELERNKVISAALLEDT 1010
T+ KE Q+ + D KES+ Q K P + E+ + A+ E+T
Sbjct: 813 VYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNL-ASPSEET 871
Query: 1011 VGEVVDVNECDLSIEKLNETISTLQQAILKISQQQEQLLMK--------SPTVPVPGS-- 1060
+ E ++ E SIEKLN ++ LQQ + ++S QQE L+ SP P P
Sbjct: 872 LNEG-EILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQSWVISPPQPSPQKQI 930
Query: 1061 ---KNNSQDHKVKAPVHFVE----PLSPTGVAGHRKAPRLGQGRNSRSGRPAELKVPKDR 1113
K + Q A F P P+ + +RK+ ++ R+ RP ELK+
Sbjct: 931 RDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSV-KSQRTPRPNELKITP-- 987
Query: 1114 PQGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSGDPHGKCLFDSYRLHD 1173
+R+ TP SV++LP LR F S + P G+P K +
Sbjct: 988 ---LNRTLTPPRSVDSLPRLRRFSPS---QVPIQTRSFVCFGDDGEPQLKESKPKEEVKK 1041
Query: 1174 ESNQRTLTLS----SSKDANILSEQMSLKEVLDASVKEVG--SSSSDVSGKESVPVEEPL 1227
E + TL + ++ I + ++ EVL V E + + D + + P +P+
Sbjct: 1042 EELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEPPPKPV 1101
Query: 1228 -----RSRASLIEVDLSDLKAPDE-DGELVSLDGSADLVS-EGDQKPGVGFFFKDEQKAE 1280
+LIEV LSDLK P++ D + DG +D + DQK GFFFKD+QKAE
Sbjct: 1102 FPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAE 1161
Query: 1281 DELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEKARRELI 1340
+++A KRAA L K+ R+ +E ++RKQQLEAE+E K++E RRK EE+R +KE+E+ARRE I
Sbjct: 1162 NDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFI 1221
Query: 1341 KQEYLRRKQQQILEEQG-LGKPKS---KPKKPRPKSVHREESCSDSGTKCSSTPDNLSRT 1396
+QEY+RRKQ +++E+ + KP+ K KK RPKS+HR+ +P +
Sbjct: 1222 RQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHI---------ESPKTPIKG 1272
Query: 1397 QSGSSLSLASAATTEPESVHSGGTPSQRVESMEALPILSRNPSRSTDRDWETASAASSLA 1456
SSLSLAS T + ESVHSG + R ES+E SR SR+ ++DWE AS SS+A
Sbjct: 1273 PPVSSLSLASLNTGDNESVHSGKR-TPRSESVEGFLSPSRCGSRNGEKDWENASTTSSVA 1331
Query: 1457 SVAEYTGPKLFKEPSSKSNKPIIHNAISHCCLAGKVNEPHKNSILEELEKCDANHYIILF 1516
S EYTGPKL+KEPS+KSNK II NA++HCCLAGKVNE K ILEE+EK DAN+++ILF
Sbjct: 1332 SGTEYTGPKLYKEPSAKSNKHIIQNALAHCCLAGKVNEGQKKKILEEMEKSDANNFLILF 1391
Query: 1517 RDAGCQFRALYCYYPDTEEIYKLTGTGPKNITKKMIDKLYKYSSDRKQFNLIPAKTMSVS 1576
RD+GCQFR+LY Y P+TEEI KLTG GPK+ITKKMI+ LYKY+SDRKQF+ IPAKT+S S
Sbjct: 1392 RDSGCQFRSLYTYCPETEEINKLTGIGPKSITKKMIEGLYKYNSDRKQFSHIPAKTLSAS 1451
Query: 1577 VDALTIHNHLWQPKRPAVPKK 1597
VDA+TIH+HLWQ KRP PKK
Sbjct: 1452 VDAITIHSHLWQTKRPVTPKK 1472
Score = 415 bits (1067), Expect = e-115
Identities = 226/488 (46%), Positives = 310/488 (63%), Gaps = 56/488 (11%)
Query: 28 PLDRYDAARAKIAANLQWICAKAYGRDNIPEDLRDPFYVDQYEQEHIKPPVIKLLLSSEL 87
P D YD +RAKIA NL W+ AKA+G +N+PE+L++PFY DQY+QEHIKPPV+ LLLS+EL
Sbjct: 21 PFDHYDFSRAKIACNLAWLVAKAFGTENVPEELQEPFYTDQYDQEHIKPPVVNLLLSAEL 80
Query: 88 YCRVCSLILKGDQVAALQGHQSVIQALSRKGIYVMESDDTPVTESDLSRAPIKMSAHMAM 147
YCR SLILK D L GH +VIQAL++KG+YV + + VTE DL + PI+MSAH+AM
Sbjct: 81 YCRAGSLILKSDAAKPLLGHDAVIQALAQKGLYVTDQEKL-VTERDLHKKPIQMSAHLAM 139
Query: 148 VDALMMAYTVEMISIEKVVASVKRFSTFSASKELPYDLEDAMVFWINKVNLKMREITEKE 207
+D LMMAYTVEM+SIEKV+A +++S F + +LPYD+EDA+++WINKVN +++I E+E
Sbjct: 140 IDTLMMAYTVEMVSIEKVIACAQQYSAFFQATDLPYDIEDAVMYWINKVNEHLKDIMEQE 199
Query: 208 VKLKQQ-LLESPAHQKVRYRREHLSARQSPYFPLLEDLMRDGSDGAALLAVIHYYCPEQM 266
KLK+ +E+P QK RYR+E +Q P PL+E+L++DG+DG AL A+IH+YCP+ +
Sbjct: 200 QKLKEHHTVEAPGGQKARYRKEQTLLKQLPCIPLVENLLKDGTDGCALAALIHFYCPDVV 259
Query: 267 KLDDICLKEVTSMADSLYNIRLLREFSNEYLNKCFYLTLEDMLYAPLVLKPNVMVFIAEL 326
+L+DICLKE S+ADSLYN++L++EF EYLN+C + TLEDMLYA +K N +VF+AEL
Sbjct: 260 RLEDICLKETMSLADSLYNLQLIQEFCQEYLNQCCHFTLEDMLYAASSIKSNYLVFMAEL 319
Query: 327 FWWFENVKPDFVQPRDVQELKDAKTVLHQKSSRPPVPISNATKRSFLGSPAAGTLAELQP 386
FWWFE VKP FVQPR V+ + A+ V P +P+ NA KR+ L S +
Sbjct: 320 FWWFEVVKPSFVQPRVVRP-QGAEPV----KDMPSIPVLNAAKRNVLDSSS--------- 365
Query: 387 PVQLPAEGCHRHYLHPEEPEYLGKGTAAFSPSHPLLPLRQKQQKSIQGEDIPDQRHRSNS 446
P+ G A F+ SH LP R + ++ RS+S
Sbjct: 366 --DFPSSG----------------EGATFTQSHHHLPSRYSRPQA--HSSASGGIRRSSS 405
Query: 447 LTRVDGQPRGAAIAWPEKKTRPASQPTPFALHHAASCEVDPSSGDSI-------SLARSI 499
++ VD G WP++K H S ++ DS+ + RSI
Sbjct: 406 MSYVD----GFIGTWPKEKRSSV---------HGVSFDISFDKEDSVQRSTPNRGITRSI 452
Query: 500 SKDSLASN 507
S + L N
Sbjct: 453 SNEGLTLN 460
>gi|130502140 NEZHA isoform 2 [Homo sapiens]
Length = 1249
Score = 367 bits (941), Expect = e-101
Identities = 305/903 (33%), Positives = 413/903 (45%), Gaps = 200/903 (22%)
Query: 750 HDFMGEAHPVVFSRYIGEEESAKLQE-DMKVKEHEDKDDASGRSSPCL------------ 796
H G + P + S Y+ E S L + K + + + SPCL
Sbjct: 486 HSPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSE 545
Query: 797 -STASQMSSVSMASGSVKMTSFAERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTW 855
S + SS + + VKMTSFAERK Q L E ++ S T PAP
Sbjct: 546 GSPKAVASSPAATNSEVKMTSFAERKKQ-LVKAEAEAGAGSPTST--------PAP---- 592
Query: 856 RQKREQSPSQHGKDPASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAF 915
L+SE+ +L +LEEKRRAIEAQK+++EA+ A+ R +LGK+AF
Sbjct: 593 ---------------PEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAF 637
Query: 916 LHVVKKGKAEAAPPLRPEHFAKEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQDVD 975
L V + E G+A E + EE P
Sbjct: 638 LQVQPR-----------------------EASGEA----------EAEAEEADSGPVPGG 664
Query: 976 KESLAFAQQHKAKDPVALHELERNKVISAALLEDTVGEVVD--VNECDLSIEKLNETIST 1033
+ Q P A +G V + E + ++ KL+ +S+
Sbjct: 665 ERPAGEGQGEPTSRP------------KAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSS 712
Query: 1034 LQQAILKISQQQEQLLMKSPTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRL 1093
LQ+ + +++ QQ++LL PGS P +V P TG
Sbjct: 713 LQRDMQRLTDQQQRLLAPPEA---PGS--------APPPAAWVIPGPTTG---------- 751
Query: 1094 GQGRNSRSGRPAELKVPKDRPQGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSA 1153
P+ +S P PA P T PG +
Sbjct: 752 --------------------PKAAS----------------PSPARRVPATRRSPGPGPS 775
Query: 1154 LEPSGDPHGKCLFDSYRLHDESNQRTLTLSSSKDANILSEQMSLKEVLDASVKEVG-SSS 1212
P H + L R LT D SL + S +V +
Sbjct: 776 QSPRSPKHTR----PAELRLAPLTRVLTPPHDVD--------SLPHLRKFSPSQVPVQTR 823
Query: 1213 SDVSGKESVPVEEPLRSRASLIEVDLSDLKAP----DEDGELVSLDGSAD--LVSEGDQK 1266
S + E P EEP +R LIE+ L L P + DG + S + SEG+ +
Sbjct: 824 SSILLAEETPPEEPA-ARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPR 882
Query: 1267 PGVGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEED 1326
G+GFF+KDE K EDE+A+KRA+ L +QQR+AEEAR RKQ E E E +R+EA R A+E+
Sbjct: 883 VGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEE 942
Query: 1327 --------------------RVRKEEEKARR--ELIKQEYLRRKQQQILEE--------- 1355
R EEE R + +QEY RR Q +++++
Sbjct: 943 APGPAPLVSAVPMATPAPAARAPAEEEVGPRKGDFTRQEYERRAQLKLMDDLDKVLRPRA 1002
Query: 1356 QGLGKP-KSKPKKPRPKSVHREESCSDSGTKCSSTPDNLSRTQSGSSLSLASAATTEPES 1414
G G P + + RP+S ++S LS+ S S+LSL++ A E +
Sbjct: 1003 AGSGGPGRGGRRATRPRSGCCDDSALARSPARGLLGSRLSKIYSQSTLSLSTVAN-EAHN 1061
Query: 1415 VHSGGTPSQRVESMEALPILSRNPSRSTDRDWETASAASSLASVAEYTGPKLFKEPSSKS 1474
P+ R S L SR P S +RDWE S ASS ASV EYTGP+L+KEPS+KS
Sbjct: 1062 NLGVKRPTSRAPSPSGLMSPSRLPG-SRERDWENGSNASSPASVPEYTGPRLYKEPSAKS 1120
Query: 1475 NKPIIHNAISHCCLAGKVNEPHKNSILEELEKCDANHYIILFRDAGCQFRALYCYYPDTE 1534
NK IIHNA+SHCCLAGKVNEP KN ILEE+EK ANH++ILFRD+ CQFRALY +TE
Sbjct: 1121 NKFIIHNALSHCCLAGKVNEPQKNRILEEIEKSKANHFLILFRDSSCQFRALYTLSGETE 1180
Query: 1535 EIYKLTGTGPKNITKKMIDKLYKYSSDRKQFNLIPAKTMSVSVDALTIHNHLWQPKRPAV 1594
E+ +L G GP+ +T M++ +YKY+SDRK+F IPAKTMS+SVDA TI HLWQ K+P
Sbjct: 1181 ELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQIPAKTMSMSVDAFTIQGHLWQGKKPTT 1240
Query: 1595 PKK 1597
PKK
Sbjct: 1241 PKK 1243
Score = 245 bits (626), Expect = 2e-64
Identities = 200/638 (31%), Positives = 299/638 (46%), Gaps = 114/638 (17%)
Query: 16 MEAPPDGAADL-----VP----LDRYDAARAKIAANLQWICAKAYG-RDNIPEDLRDPFY 65
+EA P G L VP LD+YD +RAK AA+L W+ A+G +++P +L +PFY
Sbjct: 2 VEAAPPGPGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPPELWEPFY 61
Query: 66 VDQYEQEHIKPPVIKLLLSSELYCRVCSLILKGDQVAALQGHQSVIQALSRKGIYVMESD 125
DQY QEH+KPPV +LLLS+ELYCR L Q+ +++ L+R+G V
Sbjct: 62 TDQYAQEHVKPPVTRLLLSAELYCRAWRQALP--QLETPPNPSALLALLARRGT-VPALP 118
Query: 126 DTPVTESDLSRAPIKMSAHMAMVDALMMAYTVEMISIEKVVASVKRFSTFSASKELP--- 182
+ PV E+DL PI M AH+A++DALM A+ E +K LP
Sbjct: 119 ERPVREADLRHQPILMGAHLAVIDALMAAFAFEW------------------TKTLPGPL 160
Query: 183 --YDLEDAMVFWINKVNLKMREITEKEVKLKQQLLE-----SPAHQKVRYRREHLSARQS 235
LE ++FW++ +++E TE+E + +PA +RYR++ + AR++
Sbjct: 161 ALTSLEHKLLFWVDTTVRRLQEKTEQEAAQRASPAAPADGAAPAQPSIRYRKDRVVARRA 220
Query: 236 PYFPLLEDLMRDGSDGAALLAVIHYYCPEQMKLDDICLKEVTSMADSLYNIRLLREFSNE 295
P FP + L +D + GAAL A IH YCP+ ++L+++CLK+ S+ADSLYN++L+++F
Sbjct: 221 PCFPTVTSL-QDLASGAALAATIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLVQDFCAS 279
Query: 296 YLNKCFYLTLEDMLYAPLVLKPNVMVFIAELFWWFENVKPDFVQPRDVQELKDAKTVLHQ 355
L + L+LED+LY P LK N++V +AELF FE +KPDFVQ +D+ +
Sbjct: 280 RLPRGCPLSLEDLLYVPPPLKVNLVVMLAELFMCFEVLKPDFVQVKDLPD---------- 329
Query: 356 KSSRPPVPISNATKRSFLGSPAAGTLAELQPPVQLPAEGCHRHYLHPEEPEYLGKGTAAF 415
G A+ E PP G + F
Sbjct: 330 ------------------GHAASPRGTEASPP-----------------QNNSGSSSPVF 354
Query: 416 SPSHPLLPLRQKQQKSIQGEDIPDQRHRSNSLTRVDGQPRGAAI--AWPEKKTRPASQPT 473
+ HPLL S G P R + SL A+ AW + +RP SQ
Sbjct: 355 TFRHPLL--------SSGGPQSP-LRGSTGSLKSSPSMSHMEALGKAWNRQLSRPLSQAV 405
Query: 474 PFALHHAASCEVDPSSGDSISLARSISKDSLASNIVNLTPQNQPHPTATKSHGKSLLSNV 533
F+ +VD GD + L RS+S DSL +P P T + ++
Sbjct: 406 SFSTPFGLDSDVDVVMGDPV-LLRSVSSDSLG--------PPRPAPARTPTQPPPEPGDL 456
Query: 534 SIEDEEEELVAIVRADVVPQ-QADPEFPRASPRALGLTANARSPQGQLDTSESKPDSFFL 592
+E +++ ++P AD F SP + A SP TS+ D
Sbjct: 457 PTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLA-SPYLPEGTSKPLSDRPTK 515
Query: 593 EPL-MPAVLKPAKEKQVITKEDER----GEGRPRSIVS 625
P+ MP P+K + E + EG P+++ S
Sbjct: 516 APVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVAS 553
>gi|122937255 NEZHA isoform 1 [Homo sapiens]
Length = 1276
Score = 367 bits (941), Expect = e-101
Identities = 305/903 (33%), Positives = 413/903 (45%), Gaps = 200/903 (22%)
Query: 750 HDFMGEAHPVVFSRYIGEEESAKLQE-DMKVKEHEDKDDASGRSSPCL------------ 796
H G + P + S Y+ E S L + K + + + SPCL
Sbjct: 513 HSPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSE 572
Query: 797 -STASQMSSVSMASGSVKMTSFAERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTW 855
S + SS + + VKMTSFAERK Q L E ++ S T PAP
Sbjct: 573 GSPKAVASSPAATNSEVKMTSFAERKKQ-LVKAEAEAGAGSPTST--------PAP---- 619
Query: 856 RQKREQSPSQHGKDPASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAF 915
L+SE+ +L +LEEKRRAIEAQK+++EA+ A+ R +LGK+AF
Sbjct: 620 ---------------PEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAF 664
Query: 916 LHVVKKGKAEAAPPLRPEHFAKEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQDVD 975
L V + E G+A E + EE P
Sbjct: 665 LQVQPR-----------------------EASGEA----------EAEAEEADSGPVPGG 691
Query: 976 KESLAFAQQHKAKDPVALHELERNKVISAALLEDTVGEVVD--VNECDLSIEKLNETIST 1033
+ Q P A +G V + E + ++ KL+ +S+
Sbjct: 692 ERPAGEGQGEPTSRP------------KAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSS 739
Query: 1034 LQQAILKISQQQEQLLMKSPTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRL 1093
LQ+ + +++ QQ++LL PGS P +V P TG
Sbjct: 740 LQRDMQRLTDQQQRLLAPPEA---PGS--------APPPAAWVIPGPTTG---------- 778
Query: 1094 GQGRNSRSGRPAELKVPKDRPQGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSA 1153
P+ +S P PA P T PG +
Sbjct: 779 --------------------PKAAS----------------PSPARRVPATRRSPGPGPS 802
Query: 1154 LEPSGDPHGKCLFDSYRLHDESNQRTLTLSSSKDANILSEQMSLKEVLDASVKEVG-SSS 1212
P H + L R LT D SL + S +V +
Sbjct: 803 QSPRSPKHTR----PAELRLAPLTRVLTPPHDVD--------SLPHLRKFSPSQVPVQTR 850
Query: 1213 SDVSGKESVPVEEPLRSRASLIEVDLSDLKAP----DEDGELVSLDGSAD--LVSEGDQK 1266
S + E P EEP +R LIE+ L L P + DG + S + SEG+ +
Sbjct: 851 SSILLAEETPPEEPA-ARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPR 909
Query: 1267 PGVGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEED 1326
G+GFF+KDE K EDE+A+KRA+ L +QQR+AEEAR RKQ E E E +R+EA R A+E+
Sbjct: 910 VGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEE 969
Query: 1327 --------------------RVRKEEEKARR--ELIKQEYLRRKQQQILEE--------- 1355
R EEE R + +QEY RR Q +++++
Sbjct: 970 APGPAPLVSAVPMATPAPAARAPAEEEVGPRKGDFTRQEYERRAQLKLMDDLDKVLRPRA 1029
Query: 1356 QGLGKP-KSKPKKPRPKSVHREESCSDSGTKCSSTPDNLSRTQSGSSLSLASAATTEPES 1414
G G P + + RP+S ++S LS+ S S+LSL++ A E +
Sbjct: 1030 AGSGGPGRGGRRATRPRSGCCDDSALARSPARGLLGSRLSKIYSQSTLSLSTVAN-EAHN 1088
Query: 1415 VHSGGTPSQRVESMEALPILSRNPSRSTDRDWETASAASSLASVAEYTGPKLFKEPSSKS 1474
P+ R S L SR P S +RDWE S ASS ASV EYTGP+L+KEPS+KS
Sbjct: 1089 NLGVKRPTSRAPSPSGLMSPSRLPG-SRERDWENGSNASSPASVPEYTGPRLYKEPSAKS 1147
Query: 1475 NKPIIHNAISHCCLAGKVNEPHKNSILEELEKCDANHYIILFRDAGCQFRALYCYYPDTE 1534
NK IIHNA+SHCCLAGKVNEP KN ILEE+EK ANH++ILFRD+ CQFRALY +TE
Sbjct: 1148 NKFIIHNALSHCCLAGKVNEPQKNRILEEIEKSKANHFLILFRDSSCQFRALYTLSGETE 1207
Query: 1535 EIYKLTGTGPKNITKKMIDKLYKYSSDRKQFNLIPAKTMSVSVDALTIHNHLWQPKRPAV 1594
E+ +L G GP+ +T M++ +YKY+SDRK+F IPAKTMS+SVDA TI HLWQ K+P
Sbjct: 1208 ELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQIPAKTMSMSVDAFTIQGHLWQGKKPTT 1267
Query: 1595 PKK 1597
PKK
Sbjct: 1268 PKK 1270
Score = 231 bits (589), Expect = 4e-60
Identities = 201/665 (30%), Positives = 300/665 (45%), Gaps = 141/665 (21%)
Query: 16 MEAPPDGAADL-----VP----LDRYDAARAKIAANLQWICAKAYG-RDNIPEDLRDPFY 65
+EA P G L VP LD+YD +RAK AA+L W+ A+G +++P +L +PFY
Sbjct: 2 VEAAPPGPGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPPELWEPFY 61
Query: 66 VDQYEQEHIKPPVIKLLLSSELYCRVCSLILKGDQVAALQGHQSVIQALSRKGIYVMESD 125
DQY QEH+KPPV +LLLS+ELYCR L Q+ +++ L+R+G V
Sbjct: 62 TDQYAQEHVKPPVTRLLLSAELYCRAWRQAL--PQLETPPNPSALLALLARRGT-VPALP 118
Query: 126 DTPVTESDLSRAPIKMSAHMAMVDALMMAYTVEMISIEKVVASVKRFSTFSASKELP--- 182
+ PV E+DL PI M AH+A++DALM A+ F +K LP
Sbjct: 119 ERPVREADLRHQPILMGAHLAVIDALMAAF------------------AFEWTKTLPGPL 160
Query: 183 --YDLEDAMVFWINKVNLKMREITEKEVKLKQQ--------------------------- 213
LE ++FW++ +++E TE+E +
Sbjct: 161 ALTSLEHKLLFWVDTTVRRLQEKTEQEAAQRASPAAPADGAAPAQPSCPTRWYWKLVPHA 220
Query: 214 ----LLESPAH-QKVRYRREHLSARQSPYFPLLEDLMRDGSDGAALLAVIHYYCPEQMKL 268
L ES + +RYR++ + AR++P FP + L +D + GAAL A IH YCP+ ++L
Sbjct: 221 IAFCLKESGSKPPMIRYRKDRVVARRAPCFPTVTSL-QDLASGAALAATIHCYCPQLLRL 279
Query: 269 DDICLKEVTSMADSLYNIRLLREFSNEYLNKCFYLTLEDMLYAPLVLKPNVMVFIAELFW 328
+++CLK+ S+ADSLYN++L+++F L + L+LED+LY P LK N++V +AELF
Sbjct: 280 EEVCLKDPMSVADSLYNLQLVQDFCASRLPRGCPLSLEDLLYVPPPLKVNLVVMLAELFM 339
Query: 329 WFENVKPDFVQPRDVQELKDAKTVLHQKSSRPPVPISNATKRSFLGSPAAGTLAELQPPV 388
FE +KPDFVQ +D+ + G A+ E PP
Sbjct: 340 CFEVLKPDFVQVKDLPD----------------------------GHAASPRGTEASPP- 370
Query: 389 QLPAEGCHRHYLHPEEPEYLGKGTAAFSPSHPLLPLRQKQQKSIQGEDIPDQRHRSNSLT 448
G + F+ HPLL S G P R + SL
Sbjct: 371 ----------------QNNSGSSSPVFTFRHPLL--------SSGGPQSP-LRGSTGSLK 405
Query: 449 RVDGQPRGAAI--AWPEKKTRPASQPTPFALHHAASCEVDPSSGDSISLARSISKDSLAS 506
A+ AW + +RP SQ F+ +VD GD + L RS+S DSL
Sbjct: 406 SSPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPV-LLRSVSSDSLG- 463
Query: 507 NIVNLTPQNQPHPTATKSHGKSLLSNVSIEDEEEELVAIVRADVVPQ-QADPEFPRASPR 565
+P P T + ++ +E +++ ++P AD F SP
Sbjct: 464 -------PPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPE 516
Query: 566 ALGLTANARSPQGQLDTSESKPDSFFLEPL-MPAVLKPAKEKQVITKEDER----GEGRP 620
+ A SP TS+ D P+ MP P+K + E + EG P
Sbjct: 517 GPSKPSLA-SPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSP 575
Query: 621 RSIVS 625
+++ S
Sbjct: 576 KAVAS 580
>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
Length = 749
Score = 58.9 bits (141), Expect = 4e-08
Identities = 133/580 (22%), Positives = 225/580 (38%), Gaps = 79/580 (13%)
Query: 826 NSCETKSSTSSSQKTTPDASESCPAPLTTWRQKREQSPSQHGKDPASLLASELVQLHMQ- 884
N+ +S S Q ++ P P+ ++ + + + L A E+V L +
Sbjct: 34 NASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREE 93
Query: 885 ---------LEEKRRAIEAQKKKMEALSA------RQRLKLGKAAFLHVVKKGKAEAAPP 929
LEE+++ +E Q++K E A RQRL+ K VV++ + P
Sbjct: 94 RARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKP 153
Query: 930 LRPEHFAKEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQDVDKESLAFAQQHKAKD 989
+ +HN G ++ + D D+ S++ K D
Sbjct: 154 KQ---------KHNRWSWGGSLHGSPSI------------HSADPDRRSVSTMNLSKYVD 192
Query: 990 PVALHELERNKVISAALLEDTV-GEVVDVNECDLSIEK--LNETISTLQQAILKISQQQE 1046
PV L + SA LL + ++ + S+ L T S L ++ + E
Sbjct: 193 PVISKRLSSS---SATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARSKSTAALSGE 249
Query: 1047 QLLMKSPTVPVPGSKN-NSQDHKVKAPVHFVEPLSPT-------GVAGHRKAPRLGQGRN 1098
+P + + NS D P FV P + G A ++K
Sbjct: 250 AASCSPIIMPYKAAHSRNSMDR----PKLFVTPPEGSSRRRIIHGTASYKKERERENVLF 305
Query: 1099 SRSGRPAELKVPKDRPQGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSG 1158
SG + + + +RS+ PS ++LPHL P + P + PG A
Sbjct: 306 LTSGTRRAVSPSNPKARQPARSRLWLPS-KSLPHL---PGTPRPTSSLPPGSVKAAPAQV 361
Query: 1159 DPH--GKCLFDSYRLHDESNQRTLTLSSSKDAN--ILSEQMSLKEVLDASVKEVGSSSSD 1214
P G + E ++ K AN L + L +V +A+V+E + +
Sbjct: 362 RPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPE 421
Query: 1215 VSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSEGDQKPGVGFFFK 1274
V + P P + AS + AP +VS S + + K G
Sbjct: 422 VG--PAAPAMAP--APASAPAPASAPAPAPVPTPAMVSAPSST-VNASASVKTSAGT--T 474
Query: 1275 DEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEK 1334
D ++A LA+KR L ++QR+ EE R R++Q E E + + + A+R AEE R+EEE
Sbjct: 475 DPEEATRLLAEKRR--LAREQREKEE-RERREQEELERQKREELAQRVAEERTTRREEES 531
Query: 1335 ARRELIKQEYLRRKQQQI---LEEQGLGKPKSKPKKPRPK 1371
R ++ E R K++Q+ EE+ L + + + R K
Sbjct: 532 RR---LEAEQAREKEEQLQRQAEERALREREEAERAQRQK 568
Score = 37.7 bits (86), Expect = 0.090
Identities = 52/235 (22%), Positives = 91/235 (38%), Gaps = 41/235 (17%)
Query: 1277 QKAEDELAKKRAAFLLKQQRKAE--EARVRKQQLEAEVELKRDEARRKAEED--RVRKEE 1332
++ E +LA + +L +++R + E + +++ E + +++E RR A E+ R R EE
Sbjct: 75 EEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEE 134
Query: 1333 EKARRELIKQEYLRRKQQQILEEQGL-------GKPKSKPKKPRPKSVHR---------- 1375
+K R E + + + R Q+ + G P P +SV
Sbjct: 135 DKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPV 194
Query: 1376 -EESCSDSGTKCSSTPDNLSRTQSG---SSLSLASAATTEPESVHSGGTPSQRVESMEAL 1431
+ S S ++PD R Q SS+ T S T + E+
Sbjct: 195 ISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARSKSTAALSGEAASCS 254
Query: 1432 PILSRNPSRSTDRDWETASAASSLASVAEYTGPKLF-KEPSSKSNKPIIHNAISH 1485
PI+ ++ A + +S+ PKLF P S + IIH S+
Sbjct: 255 PII---------MPYKAAHSRNSM------DRPKLFVTPPEGSSRRRIIHGTASY 294
Score = 31.2 bits (69), Expect = 8.4
Identities = 36/123 (29%), Positives = 60/123 (48%), Gaps = 13/123 (10%)
Query: 1294 QQRKAEEARV-RKQQLEAE--VELKRDEARR----KAEEDRVRKEEEKARRELIKQEYLR 1346
+QR A E R R++QL A V L+R+E R K E+R ++ EE+ ++E ++ +
Sbjct: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
Query: 1347 RKQQQILEEQGLGKP----KSKPKKPRPKSVHREESCSDS--GTKCSSTPDNLSRTQSGS 1400
K++Q LEE ++ + +PK H S S G+ + D R+ S
Sbjct: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTM 185
Query: 1401 SLS 1403
+LS
Sbjct: 186 NLS 188
>gi|221219024 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 53.9 bits (128), Expect = 1e-06
Identities = 128/619 (20%), Positives = 232/619 (37%), Gaps = 53/619 (8%)
Query: 788 ASGRSSPCLSTASQMSSVSMASGSVKMTSFAERKLQRLNSCETKSSTSSSQKTTPDA-SE 846
A R S L+ AS SS + ++ ER + N E SST S+Q+ DA S
Sbjct: 649 AGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEE-NLKEECSSTESTQQEHEDAPST 707
Query: 847 SCPAPLTTWRQKREQSPSQHGKDPASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQ 906
+ ++R Q L + +L QL+E R E ++ ++ +
Sbjct: 708 KLQGEVLALEEERAQVLGH-----VEQLKVRVKELEQQLQESAREAEMERALLQGEREAE 762
Query: 907 RLKLGKAAFLHVVKKGKAEAAPPLRPEHFAKEYSQHNGEDCGDAVSKTEDFLVKEEQREE 966
R L K + +A L+ + A E D +TE L ++ + ++
Sbjct: 763 RALLQK----------EQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQ 812
Query: 967 LLHEPQDVDKESLAFAQQHKAKDPVALHELERNKVISAALLEDTVGEV--VDVNECDLSI 1024
L E + ++ LA ++K + +R + + A+L+ G++ V E +
Sbjct: 813 LERESRVEEERELAGQGLLRSKAELLRSIAKRKERL--AILDSQAGQIRAQAVQESERLA 870
Query: 1025 EKLNETISTLQQAILKISQQQEQLLMKSPTVPVPGSKNNSQD-HKVKAPVHFVEPLSPTG 1083
N ++ LQ+ K++ + + + P P + + ++ K+ P +E
Sbjct: 871 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL 930
Query: 1084 VAGHRKAPRLGQGRNSRSGRPAELKVPKDRPQGSSRSKTPTPSVETLPHLR--PFPASSH 1141
+AG P +S P L R RSK + LP R P P+SS
Sbjct: 931 MAGLGTGPAAASPHSS----PPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSG 986
Query: 1142 PRTPTDPGLDSALEPSGDPHGKCLFDS----------YRLHDESNQRTLTLSSSKDANIL 1191
+ + + L S P L + L D +R L L I
Sbjct: 987 SSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIE 1046
Query: 1192 SEQMSLKEVLDASVKEVGSSSSDVSGKESVPVEE----PLRSRASLIEVDLSDLKAPDED 1247
++ L E+ + E + G P PL + L + + E+
Sbjct: 1047 EQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAG--RERGEE 1104
Query: 1248 GE----LVSLDGSADLVSEGDQKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARV 1303
GE +SL+ S+D + G D + L + + K ++A +
Sbjct: 1105 GEHAYDTLSLE-SSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKN 1163
Query: 1304 R-KQQLEAEVELKR---DEARRKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLG 1359
R + E E+EL+R +E RR+ E+ R + E ARR+ + ++ ++ +++Q + + L
Sbjct: 1164 RLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLT 1223
Query: 1360 KPKSKPKKPRPKSVHREES 1378
+ K+ H E S
Sbjct: 1224 RYLPIRKEDFDLKTHIESS 1242
>gi|38424073 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 53.9 bits (128), Expect = 1e-06
Identities = 128/619 (20%), Positives = 232/619 (37%), Gaps = 53/619 (8%)
Query: 788 ASGRSSPCLSTASQMSSVSMASGSVKMTSFAERKLQRLNSCETKSSTSSSQKTTPDA-SE 846
A R S L+ AS SS + ++ ER + N E SST S+Q+ DA S
Sbjct: 649 AGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEE-NLKEECSSTESTQQEHEDAPST 707
Query: 847 SCPAPLTTWRQKREQSPSQHGKDPASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQ 906
+ ++R Q L + +L QL+E R E ++ ++ +
Sbjct: 708 KLQGEVLALEEERAQVLGH-----VEQLKVRVKELEQQLQESAREAEMERALLQGEREAE 762
Query: 907 RLKLGKAAFLHVVKKGKAEAAPPLRPEHFAKEYSQHNGEDCGDAVSKTEDFLVKEEQREE 966
R L K + +A L+ + A E D +TE L ++ + ++
Sbjct: 763 RALLQK----------EQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQ 812
Query: 967 LLHEPQDVDKESLAFAQQHKAKDPVALHELERNKVISAALLEDTVGEV--VDVNECDLSI 1024
L E + ++ LA ++K + +R + + A+L+ G++ V E +
Sbjct: 813 LERESRVEEERELAGQGLLRSKAELLRSIAKRKERL--AILDSQAGQIRAQAVQESERLA 870
Query: 1025 EKLNETISTLQQAILKISQQQEQLLMKSPTVPVPGSKNNSQD-HKVKAPVHFVEPLSPTG 1083
N ++ LQ+ K++ + + + P P + + ++ K+ P +E
Sbjct: 871 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL 930
Query: 1084 VAGHRKAPRLGQGRNSRSGRPAELKVPKDRPQGSSRSKTPTPSVETLPHLR--PFPASSH 1141
+AG P +S P L R RSK + LP R P P+SS
Sbjct: 931 MAGLGTGPAAASPHSS----PPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSG 986
Query: 1142 PRTPTDPGLDSALEPSGDPHGKCLFDS----------YRLHDESNQRTLTLSSSKDANIL 1191
+ + + L S P L + L D +R L L I
Sbjct: 987 SSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIE 1046
Query: 1192 SEQMSLKEVLDASVKEVGSSSSDVSGKESVPVEE----PLRSRASLIEVDLSDLKAPDED 1247
++ L E+ + E + G P PL + L + + E+
Sbjct: 1047 EQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAG--RERGEE 1104
Query: 1248 GE----LVSLDGSADLVSEGDQKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARV 1303
GE +SL+ S+D + G D + L + + K ++A +
Sbjct: 1105 GEHAYDTLSLE-SSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKN 1163
Query: 1304 R-KQQLEAEVELKR---DEARRKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLG 1359
R + E E+EL+R +E RR+ E+ R + E ARR+ + ++ ++ +++Q + + L
Sbjct: 1164 RLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLT 1223
Query: 1360 KPKSKPKKPRPKSVHREES 1378
+ K+ H E S
Sbjct: 1224 RYLPIRKEDFDLKTHIESS 1242
>gi|13027602 DDRGK domain containing 1 [Homo sapiens]
Length = 314
Score = 53.9 bits (128), Expect = 1e-06
Identities = 47/148 (31%), Positives = 77/148 (52%), Gaps = 29/148 (19%)
Query: 1276 EQKAEDELAKKRAAFLL---------KQQRKAEEA-RVRKQQLEA--EVELKRDEARRKA 1323
E+ AE L+ K A L K QR+AEEA R +++LE+ E E K++E R +
Sbjct: 106 EKPAETHLSGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRL 165
Query: 1324 EEDRVRKEEEKARRELIK---QEYLRRKQQQILEEQGLGKPKSKPKK-----------PR 1369
EE++ +EE KAR E + +EYL+ K+ ++EE+G+G+ ++ + +
Sbjct: 166 EEEQKEEEERKAREEQAQREHEEYLKLKEAFVVEEEGVGETMTEEQSQSFLTEFINYIKQ 225
Query: 1370 PKSVHREESCSDSGTKCSSTPDNLSRTQ 1397
K V E+ S G + T D ++R Q
Sbjct: 226 SKVVLLEDLASQVGLR---TQDTINRIQ 250
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 52.4 bits (124), Expect = 4e-06
Identities = 27/98 (27%), Positives = 57/98 (58%)
Query: 1280 EDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEKARREL 1339
+++L K++ +++ E R ++++ E E + + +E ++ EE +R+E EK RR+
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955
Query: 1340 IKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
+++Y + K+ Q EEQ LG+ K ++ + +REE
Sbjct: 956 RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREE 993
Score = 50.8 bits (120), Expect = 1e-05
Identities = 28/105 (26%), Positives = 61/105 (58%), Gaps = 3/105 (2%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQ-RKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEE 1332
+ E++ E +L +++ +QQ R+ +E R+QQL E +L+R++ R+ E ++R+E+
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRR--EQQLRREQ 399
Query: 1333 EKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
+ R + +++E R++QQ+ EQ L + + + + + R E
Sbjct: 400 QLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE 444
Score = 50.8 bits (120), Expect = 1e-05
Identities = 31/109 (28%), Positives = 62/109 (56%), Gaps = 5/109 (4%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEE---DRVRK 1330
+ EQ+ E ++R L +++ K E R+Q+L+ E E +RD+ ++ EE R+++
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR 592
Query: 1331 EEEKARRELIKQEYLRRKQQQILEEQGLGK--PKSKPKKPRPKSVHREE 1377
E+E+ + +K+E + R +Q+ EQ L + P+ + ++ KS +EE
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641
Score = 50.8 bits (120), Expect = 1e-05
Identities = 33/115 (28%), Positives = 60/115 (52%), Gaps = 11/115 (9%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQL-----------EAEVELKRDEARRK 1322
++EQ +E +R L +Q RK EE + ++QL E E + + +E ++
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQ 1118
Query: 1323 AEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
EE +R+E EK RR+ ++++Y ++ Q EEQ L + K ++ + +REE
Sbjct: 1119 EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173
Score = 49.7 bits (117), Expect = 2e-05
Identities = 26/102 (25%), Positives = 63/102 (61%), Gaps = 3/102 (2%)
Query: 1276 EQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEKA 1335
E + E+E +K L+++R+ EE + ++ + E ++ K++E RR+ +E+R ++E +
Sbjct: 270 ELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE 329
Query: 1336 RRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
++E +++ LRR+Q++ E+Q + + ++ R + + RE+
Sbjct: 330 QQEERREQQLRREQEERREQQ---LRREQEEERREQQLRREQ 368
Score = 49.7 bits (117), Expect = 2e-05
Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 11/115 (9%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQL-----------EAEVELKRDEARRK 1322
++EQ +E K+R +Q R+ EE + ++QL E E + + +E ++
Sbjct: 1089 EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ 1148
Query: 1323 AEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
EE +R+E EK RR+ ++++Y ++ Q EEQ L + + K ++ R + EE
Sbjct: 1149 EEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEE 1203
Score = 48.9 bits (115), Expect = 4e-05
Identities = 27/104 (25%), Positives = 59/104 (56%), Gaps = 3/104 (2%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEE 1333
+ E++ E + +++ +QQ + E+ R+QQL E E +R E + + E++ R+E++
Sbjct: 317 QQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQ 376
Query: 1334 KARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
R + +++E R++QQ+ EQ L + + + R + + RE+
Sbjct: 377 LRREQQLRREQQLRREQQLRREQQL---RREQQLRREQQLRREQ 417
Score = 48.5 bits (114), Expect = 5e-05
Identities = 33/107 (30%), Positives = 65/107 (60%), Gaps = 9/107 (8%)
Query: 1277 QKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEA-RRKAEEDR----VRKE 1331
+K E+E +++ +Q+R+ ++ R+QQL E E +R++ RR+ EE+R +R+E
Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE 367
Query: 1332 EEKARRE-LIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
+E+ RRE +++E R++QQ+ EQ L + + + R + + RE+
Sbjct: 368 QEEERREQQLRREQQLRREQQLRREQQL---RREQQLRREQQLRREQ 411
Score = 48.5 bits (114), Expect = 5e-05
Identities = 27/104 (25%), Positives = 60/104 (57%), Gaps = 1/104 (0%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEE 1333
+ E++ E +L +++ +Q R+ +E R+QQL E E +R E + + E+ ++R+E++
Sbjct: 330 QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ-QLRREQQ 388
Query: 1334 KARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
R + +++E R++QQ+ EQ L + + ++ + + EE
Sbjct: 389 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432
Score = 48.5 bits (114), Expect = 5e-05
Identities = 33/116 (28%), Positives = 64/116 (55%), Gaps = 14/116 (12%)
Query: 1276 EQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDR----VRKE 1331
EQ+ + E ++R L +++ + ++ R+Q+ E LKR+E R +E+R +++E
Sbjct: 564 EQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKRE 623
Query: 1332 E--EKARRELIK--------QEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
E E+ R++L+K Q+ LRR+QQ+ E++ + + + + R K H EE
Sbjct: 624 EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEE 679
Score = 47.8 bits (112), Expect = 9e-05
Identities = 31/115 (26%), Positives = 61/115 (53%), Gaps = 11/115 (9%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQL-----------EAEVELKRDEARRK 1322
++EQ +E K+R +Q RK ++ + +++QL E E + + +E ++
Sbjct: 939 EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ 998
Query: 1323 AEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
EE +R+E EK RR+ +++Y ++ + Q EEQ L + + K + + +REE
Sbjct: 999 EEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE 1053
Score = 47.4 bits (111), Expect = 1e-04
Identities = 30/107 (28%), Positives = 62/107 (57%), Gaps = 5/107 (4%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARR---KAEEDRVRK 1330
+ E++ E L ++ L+Q+ ++E+ R+Q+ E LKR+E +R + E R+++
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKR 569
Query: 1331 EEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
E+E+ R +L+K+E RR QQ L+ + + + + K+ + + +EE
Sbjct: 570 EQEERRDQLLKREEERR--QQRLKREQEERLEQRLKREEVERLEQEE 614
Score = 47.0 bits (110), Expect = 1e-04
Identities = 29/115 (25%), Positives = 63/115 (54%), Gaps = 15/115 (13%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEED------- 1326
K + K + E ++ L+++ + E+ R+QQL E E +R++ ++ EE+
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL 532
Query: 1327 ----RVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
++R+E+E+ R +L+K+E +R +Q+ E+ + K + ++ R + + REE
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQ----RLKREQEERRDQLLKREE 583
Score = 45.8 bits (107), Expect = 3e-04
Identities = 32/99 (32%), Positives = 56/99 (56%), Gaps = 10/99 (10%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEE 1333
++EQ +E K+R L +Q R+ EE + ++QL E E RR+ E +R +EEE
Sbjct: 1119 EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE----EPEKRRRQELERQYREEE 1174
Query: 1334 KARRE---LIKQEYLRRKQQ---QILEEQGLGKPKSKPK 1366
+ ++E L+++E +R+Q+ Q EE+ L + K K +
Sbjct: 1175 ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213
Score = 45.1 bits (105), Expect = 6e-04
Identities = 30/116 (25%), Positives = 60/116 (51%), Gaps = 12/116 (10%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQL-----------EAEVELKRDEARRK 1322
++EQ +E K+R +Q RK +E + ++QL E E + + +E ++
Sbjct: 999 EEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ 1058
Query: 1323 AEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGL-GKPKSKPKKPRPKSVHREE 1377
EE + +E E RR+ ++++Y + ++ Q EEQ L +P+ + ++ R + EE
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEE 1114
Score = 44.3 bits (103), Expect = 0.001
Identities = 27/106 (25%), Positives = 58/106 (54%), Gaps = 3/106 (2%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAE--EDRVRKE 1331
+++Q ++ ++ +QQ + E+ R+QQL E E +R E + + E E R+++E
Sbjct: 391 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450
Query: 1332 EEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
+E+ RR+ +K+E + +Q +Q L + + + ++ R + EE
Sbjct: 451 QEE-RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE 495
Score = 44.3 bits (103), Expect = 0.001
Identities = 26/83 (31%), Positives = 47/83 (56%), Gaps = 5/83 (6%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEE 1333
++EQ +E K+R L +Q R+ EE + ++QL L+ ++ +R+ E +R +EEE
Sbjct: 1149 EEEQLLREEPEKRRRQELERQYREEEELQQEEEQL-----LREEQEKRRQERERQYREEE 1203
Query: 1334 KARRELIKQEYLRRKQQQILEEQ 1356
+ +R+ KQ Y Q+ L+ Q
Sbjct: 1204 ELQRQKRKQRYRDEDQRSDLKWQ 1226
Score = 43.5 bits (101), Expect = 0.002
Identities = 52/218 (23%), Positives = 98/218 (44%), Gaps = 29/218 (13%)
Query: 1170 RLHDESNQRTLTLSSSKDANILSEQMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLRS 1229
RL QR +D + ++ +E + +E S E P EE LR
Sbjct: 160 RLEQRDRQR-------RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212
Query: 1230 RASLIEVDLSDLKAPDEDGELVSLDGSADLV----SEGDQKPGVGFFFKDEQKAEDELAK 1285
R +L +L+ + + D V E + + K+E+K ++E +
Sbjct: 213 R------ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266
Query: 1286 KRAAFLLKQQ--RKAEEARVRKQQLEAEVELKR----DEARRKAEEDRVRKEEEKARREL 1339
++ +++ RK E +R+++ E E + +R + RRK EE+R +E+++ RRE
Sbjct: 267 RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER--REQQEERRE- 323
Query: 1340 IKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
+QE RR+QQ+ EQ L + + + ++ + + EE
Sbjct: 324 -QQE--RREQQEERREQQLRREQEERREQQLRREQEEE 358
Score = 43.5 bits (101), Expect = 0.002
Identities = 30/104 (28%), Positives = 57/104 (54%), Gaps = 6/104 (5%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEE 1333
++E++ E + ++R ++QR E R+ L+ E E +R E R+ ++ + +EEE
Sbjct: 429 QEEERHEQKHEQER-----REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEE 483
Query: 1334 KARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
+ R L +E RR+QQ+ E+Q L + + + ++ R K EE
Sbjct: 484 RRERWLKLEEEERREQQERREQQ-LRREQEERREQRLKRQEEEE 526
Score = 43.5 bits (101), Expect = 0.002
Identities = 29/105 (27%), Positives = 59/105 (56%), Gaps = 3/105 (2%)
Query: 1276 EQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEKA 1335
EQ+ + E ++R +++ + E RKQQL+ + E +R E K EE+ R+++E+
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR 503
Query: 1336 RRELIKQEYLRRKQ---QQILEEQGLGKPKSKPKKPRPKSVHREE 1377
++L +++ RR+Q +Q EE+ + +S+ + R + RE+
Sbjct: 504 EQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Score = 43.1 bits (100), Expect = 0.002
Identities = 29/104 (27%), Positives = 58/104 (55%), Gaps = 4/104 (3%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEE 1333
+D K E+E + +Q ++ +E R++ L+ E E +R++ R+ ++ R R++EE
Sbjct: 455 RDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR-REQEE 513
Query: 1334 KARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
+ + L +QE R QQ++ EQ L + + ++ R + + REE
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQL---RREQEERREQLLKREE 554
Score = 43.1 bits (100), Expect = 0.002
Identities = 34/121 (28%), Positives = 64/121 (52%), Gaps = 17/121 (14%)
Query: 1272 FFKDEQKAEDELAKK-RAAFLLKQQRKAEEARVRKQQ-----LEAEVELKRDEARRKAEE 1325
F ++EQ+ E +K R L Q+R EE ++ +Q+ LE E +L+R E RK E
Sbjct: 1448 FLEEEQQLRQERHRKFREEEQLLQER--EEQQLHRQERDRKFLEEEQQLRRQERDRKFRE 1505
Query: 1326 DRVR---------KEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHRE 1376
+R +EE++ R+ ++++L+ +QQ +E+G + + + +K R + R+
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565
Query: 1377 E 1377
E
Sbjct: 1566 E 1566
Score = 42.7 bits (99), Expect = 0.003
Identities = 90/531 (16%), Positives = 208/531 (39%), Gaps = 37/531 (6%)
Query: 858 KREQSPSQHGKDPASLLASELVQLHMQLEEKRRA----IEAQKKKMEALSARQRLKLGKA 913
KRE+ +H ++ QL EE+RR +E ++++ + Q+L+ +
Sbjct: 459 KREEETERHEQERRKQ------QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE 512
Query: 914 AFLHVVKKGKAEAAPPLRPEHFAKEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQD 973
K + E + ++ + E + + E+ +++E+RE+ L Q+
Sbjct: 513 ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQE 572
Query: 974 VDKESLAFAQQHKAKDPVALHELERNKVISAALLEDTVGEVVDVNECDLSIEKLNETIST 1033
++ L ++ + + + + ER + L + V E ++ E K E
Sbjct: 573 ERRDQLLKREEERRQQRLKREQEER---LEQRLKREEV-ERLEQEERREQRLKREEPEEE 628
Query: 1034 LQQAILKISQQQEQLLMKSPTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRL 1093
+Q +LK +Q+E+ + + + Q K + +E R+ L
Sbjct: 629 RRQQLLKSEEQEER---RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQEL 685
Query: 1094 GQGRNSRSGRPAELKVPKDRPQGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSA 1153
+ ++ + ++PK + Q S + V + P + + +S
Sbjct: 686 AEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE 745
Query: 1154 LEPSGDPHGKCLFDSYRLHDESNQRT-------LTLSSSKDANILSEQMSLKEVLDASVK 1206
L+ + ++R E QR S + LS + L+E + +
Sbjct: 746 LQWQEEER------AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE---R 796
Query: 1207 EVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSEGDQK 1266
++ + + +P EE R +L+ +E+ +L + + L E D
Sbjct: 797 QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGL 856
Query: 1267 PGVGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEED 1326
++ ++++++ ++ + L+++RK + + E K + ++ EE+
Sbjct: 857 QED----QERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEE 912
Query: 1327 RVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
R+E EK RR+ +++Y +Q Q EEQ L + + K ++ + +R++
Sbjct: 913 LQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963
Score = 42.0 bits (97), Expect = 0.005
Identities = 28/107 (26%), Positives = 59/107 (55%), Gaps = 3/107 (2%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQL---EAEVELKRDEARRKAEEDRVRK 1330
K+EQ +E K+R K+ R+ EE + ++QL E E +++ R+ ++D +++
Sbjct: 969 KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ 1028
Query: 1331 EEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
EEE+ RE ++ L+ +++Q EE+ L + + + ++ R+E
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE 1075
Score = 41.6 bits (96), Expect = 0.006
Identities = 29/103 (28%), Positives = 59/103 (57%), Gaps = 6/103 (5%)
Query: 1277 QKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEKAR 1336
++ E+E ++R + +RK EE R R+QQ E + +R E + + E ++R+E+E+ R
Sbjct: 289 ERQEEEQQQQRLRREQQLRRKQEEER-REQQEERREQQERREQQEERREQQLRREQEERR 347
Query: 1337 RELIK--QEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
+ ++ QE RR+QQ E++ + + + + R + + RE+
Sbjct: 348 EQQLRREQEEERREQQLRREQE---EERREQQLRREQQLRREQ 387
Score = 41.6 bits (96), Expect = 0.006
Identities = 40/143 (27%), Positives = 82/143 (57%), Gaps = 18/143 (12%)
Query: 1240 DLKAPDEDGELVSLDGSADLVSEGDQKPGVGFFFKDEQKAEDELAKKRAAFLLKQQR--- 1296
D K +E+ +L + L + D+K F++E++ E +++ L +Q+R
Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRHDRDRK------FREEEQLLQEGEEQQ---LRRQERDRK 1692
Query: 1297 -KAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEKARRELIKQEYLRRKQ--QQIL 1353
+ EE ++R+Q+ E + L+ ++ R+ E +R +EEE+ R+E +QE LRR++ ++IL
Sbjct: 1693 FREEEQQLRRQERERKF-LQEEQQLRRQELERKFREEEQLRQE-TEQEQLRRQERYRKIL 1750
Query: 1354 EEQGLGKPKSKPKKPRPKSVHRE 1376
EE+ L +P+ + ++ R + R+
Sbjct: 1751 EEEQL-RPEREEQQLRRQERDRK 1772
Score = 40.8 bits (94), Expect = 0.011
Identities = 27/115 (23%), Positives = 60/115 (52%), Gaps = 11/115 (9%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQL-----------EAEVELKRDEARRK 1322
++E+ +E K+R +Q R+ E+ + ++QL E E + ++D+ ++
Sbjct: 909 EEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ 968
Query: 1323 AEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
EE + +E EK RR+ +++Y ++ Q EEQ L + + K ++ + +R++
Sbjct: 969 KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023
Score = 40.8 bits (94), Expect = 0.011
Identities = 23/104 (22%), Positives = 59/104 (56%), Gaps = 8/104 (7%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEE 1333
+ +Q+ +D K R L+Q+R EE ++ +Q+ + + L+ + RR+ +E + ++E+
Sbjct: 1545 RGQQRRQDRDRKFREEEQLRQER--EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQ 1602
Query: 1334 KARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
+ RR+ +Q+ + + ++ E++ L + + + + +HR+E
Sbjct: 1603 QLRRQEGQQQLRQERDRKFREDEQLLQEREE------QQLHRQE 1640
Score = 40.4 bits (93), Expect = 0.014
Identities = 30/110 (27%), Positives = 60/110 (54%), Gaps = 7/110 (6%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQR-KAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEE 1332
+ E++ E L ++ +QQ K+EE R+QQ +L+R++ R+ E+ R+EE
Sbjct: 611 EQEERREQRLKREEPEEERRQQLLKSEEQEERRQQ-----QLRREQQERR-EQRLKREEE 664
Query: 1333 EKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSDS 1382
E+ + +K+E+ +++Q L E+ + + + K PK + ES +D+
Sbjct: 665 EERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADA 714
Score = 40.4 bits (93), Expect = 0.014
Identities = 21/117 (17%), Positives = 63/117 (53%), Gaps = 12/117 (10%)
Query: 1273 FKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEE 1332
F++E++ E +++ ++ EE ++R+++ E ++ ++ + + + EE++++ EE
Sbjct: 1773 FREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEE 1832
Query: 1333 E------------KARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
+ +A + QE RR++Q++ +E+ + + + +K R + + R++
Sbjct: 1833 QEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQ 1889
Score = 39.7 bits (91), Expect = 0.024
Identities = 23/79 (29%), Positives = 48/79 (60%), Gaps = 6/79 (7%)
Query: 1295 QRKAEEARVRKQ---QLEAEVELKRDEARRKAEEDRVRKEEEKARRE---LIKQEYLRRK 1348
Q + +E R+R++ Q AE + E R+ E++ ++EE+K R+E +++E++RR+
Sbjct: 1829 QLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQ 1888
Query: 1349 QQQILEEQGLGKPKSKPKK 1367
Q++ + +G+ KS+ K
Sbjct: 1889 QKEEQRHRQVGEIKSQEGK 1907
Score = 39.3 bits (90), Expect = 0.031
Identities = 22/83 (26%), Positives = 49/83 (59%), Gaps = 4/83 (4%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEE 1333
+++Q ++ ++ +QQ + E+ R+QQL E +L+R++ R+ ++ R R++EE
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR-REQEE 431
Query: 1334 KARRELIKQEYLRRKQQQILEEQ 1356
+ + +QE R++Q++ EQ
Sbjct: 432 ERHEQKHEQE---RREQRLKREQ 451
Score = 38.9 bits (89), Expect = 0.040
Identities = 34/124 (27%), Positives = 63/124 (50%), Gaps = 22/124 (17%)
Query: 1273 FKDEQKAEDELAKKRAAFLLKQQRKAEEARVRK-----QQL---EAEVELKRDEARRKAE 1324
F++E+ E +K FL ++QR + R RK QQL E E +L++D R+ E
Sbjct: 1362 FREEELRHQEQGRK---FLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418
Query: 1325 ED----------RVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPR-PKSV 1373
E+ + R+EE++ RR+ ++++L +QQ E + + + + R + +
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQL 1478
Query: 1374 HREE 1377
HR+E
Sbjct: 1479 HRQE 1482
Score = 38.5 bits (88), Expect = 0.053
Identities = 33/139 (23%), Positives = 65/139 (46%), Gaps = 16/139 (11%)
Query: 1254 DGSADLVSEGDQKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRK---AEEARVRKQQLEA 1310
DG L+ + Q+ F +++ E+E ++R +Q+R+ EE ++++LE
Sbjct: 104 DGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQ 163
Query: 1311 EVELKRDEA------------RRKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGL 1358
+RDE R+AEE++++ + E +E LRR++ L +G
Sbjct: 164 RDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKG- 222
Query: 1359 GKPKSKPKKPRPKSVHREE 1377
+ K + ++ R V +EE
Sbjct: 223 REEKQQQRRERQDRVFQEE 241
Score = 38.1 bits (87), Expect = 0.069
Identities = 49/227 (21%), Positives = 99/227 (43%), Gaps = 19/227 (8%)
Query: 1157 SGDPHGKCLFDSYRLHDESNQRTLTLSSSKDANILSEQMSLKEVLDASVKEVGSSSSDVS 1216
S +P K L + +LH + QR L + ++ D +E +
Sbjct: 1510 SQEPERKFLEEEQQLHRQQRQRKF-LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQERE 1568
Query: 1217 GKESVPVEEPLRSRASLIEV--DLSDLKAPDEDGELVSLDGSADLVSEGDQKPGVGFFFK 1274
++ E + R +V + K +++ +L +G L E D+K F +
Sbjct: 1569 EQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRK-----FRE 1623
Query: 1275 DEQKAEDELAKKRAAFLLKQQRKA----EEARVRKQQLEAEVELKRDEARRKAEEDRVRK 1330
DEQ ++ ++ L +Q+R EE ++R+Q E E +L+ D R+ EE+++ +
Sbjct: 1624 DEQLLQEREEQQ----LHRQERDRKFLEEEPQLRRQ--EREQQLRHDRDRKFREEEQLLQ 1677
Query: 1331 E-EEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHRE 1376
E EE+ R + R ++QQ+ ++ K + ++ R + + R+
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERK 1724
Score = 36.6 bits (83), Expect = 0.20
Identities = 22/69 (31%), Positives = 41/69 (59%), Gaps = 1/69 (1%)
Query: 1291 LLKQQRKAEEARVRKQQLEAEV-ELKRDEARRKAEEDRVRKEEEKARRELIKQEYLRRKQ 1349
L ++++K + R RK Q E ++ +R+E RR+ E DR +EEE+ +E +Q R+++
Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358
Query: 1350 QQILEEQGL 1358
+ E+ L
Sbjct: 1359 DRKFREEEL 1367
Score = 35.8 bits (81), Expect = 0.34
Identities = 28/107 (26%), Positives = 57/107 (53%), Gaps = 6/107 (5%)
Query: 1271 FFFKDEQKAEDELAKK-RAAFLLKQQRKAEEAR----VRKQQLEAEVELKRDEAR-RKAE 1324
F +++Q EL +K R L+Q+ + E+ R RK E ++ +R+E + R+ E
Sbjct: 1709 FLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQE 1768
Query: 1325 EDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPK 1371
DR +EEE+ R+E +Q+ ++ + E+ + + + ++ RP+
Sbjct: 1769 RDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQ 1815
Score = 35.4 bits (80), Expect = 0.45
Identities = 32/114 (28%), Positives = 56/114 (49%), Gaps = 14/114 (12%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQ-----LEAEVELKRDEARRK--AEED 1326
+D + E+E +R ++ RK E +R Q+ LE E +L R + +RK EE
Sbjct: 1483 RDRKFLEEEQQLRRQ----ERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQ 1538
Query: 1327 RVRKEEEKARRELIKQEYLRRKQQ--QILEEQGLGKPKSKPK-KPRPKSVHREE 1377
++R++E +R + R ++Q Q EEQ L + + K + + V R+E
Sbjct: 1539 QLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQE 1592
Score = 35.0 bits (79), Expect = 0.58
Identities = 24/110 (21%), Positives = 55/110 (50%), Gaps = 7/110 (6%)
Query: 1291 LLKQQRKAEEAR---VRKQQLEAEVELKRDEARRKAEEDRVRKEEEKARRELIKQEYLRR 1347
LL+ +R+ E+ R R +QLE E +R + R++ E + EE+ ++E ++Q +R
Sbjct: 109 LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQR 168
Query: 1348 KQQQILEEQGLGKPKSKPKKPRPKSVHREESCSDSGTKCSSTPDNLSRTQ 1397
+ +++ + + + + ++ R + +SC T+ + L R +
Sbjct: 169 RDEELWRQ----RQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Score = 34.7 bits (78), Expect = 0.76
Identities = 25/96 (26%), Positives = 54/96 (56%), Gaps = 8/96 (8%)
Query: 1273 FKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELK-RDEARRKAEEDRVRKE 1331
F++E++ E +++ + ++ EE ++R ++ E ++ + RD R+ E+ R +E
Sbjct: 1725 FREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQERE 1784
Query: 1332 EEKAR-----RELIKQEYLR--RKQQQILEEQGLGK 1360
E++ R R+ ++E LR R++QQ+ +Q GK
Sbjct: 1785 EQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK 1820
Score = 34.3 bits (77), Expect = 0.99
Identities = 27/117 (23%), Positives = 60/117 (51%), Gaps = 15/117 (12%)
Query: 1276 EQKAEDELAKKRAAFLLKQQRKAEEARVRKQ----QLEAEVELKRDEARRKAEEDRVR-- 1329
++K+++E R K++R+ + + R++ Q E L+R E RK E+ +R
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370
Query: 1330 -------KEEEKARRELIKQEYLRRKQQQILE--EQGLGKPKSKPKKPRPKSVHREE 1377
+EE++ RR+ ++++L+ +QQ + EQ L + + + + + + R+E
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQE 1427
Score = 34.3 bits (77), Expect = 0.99
Identities = 28/93 (30%), Positives = 52/93 (55%), Gaps = 11/93 (11%)
Query: 1272 FFKDEQKA-----EDELAKKR-AAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRK--A 1323
F K+EQ+ E +L + R F ++Q+ + + R RK + E E +++R E RK
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFR-EEEQQVRRQERERKFLE 1450
Query: 1324 EEDRVRKEEEKARRELIKQEYLRRKQQQILEEQ 1356
EE ++R+E + RE +++ L+ +++Q L Q
Sbjct: 1451 EEQQLRQERHRKFRE--EEQLLQEREEQQLHRQ 1481
Score = 33.5 bits (75), Expect = 1.7
Identities = 25/98 (25%), Positives = 53/98 (54%), Gaps = 11/98 (11%)
Query: 1291 LLKQQR----KAEEARVRKQQ-----LEAEVELKRDEARRKAEEDRV--RKEEEKARREL 1339
L +Q+R + EE +VR+Q+ LE E +L+++ R+ EE+++ +EE++ R+
Sbjct: 1423 LSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE 1482
Query: 1340 IKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREE 1377
+++L +QQ +E+ + + + P+ EE
Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEE 1520
Score = 33.1 bits (74), Expect = 2.2
Identities = 32/119 (26%), Positives = 60/119 (50%), Gaps = 16/119 (13%)
Query: 1275 DEQKAEDELAKKRAAFLL--KQQRKAEEARVRKQQLEA----EVELKRDEAR------RK 1322
++ + D +++ LL +Q+R E+ R R QQ + E +L+R+E + RK
Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK 1313
Query: 1323 AEEDR--VRKEEEKARRELIKQEYLRRKQQ--QILEEQGLGKPKSKPKKPRPKSVHREE 1377
++E++ +R+E E+ RR R ++Q Q EEQ L + + K + H+E+
Sbjct: 1314 SQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ 1372
Score = 32.7 bits (73), Expect = 2.9
Identities = 27/86 (31%), Positives = 48/86 (55%), Gaps = 5/86 (5%)
Query: 1295 QRKAEEARVRKQQLEAEVELKRDEARRKA-EEDRVR--KEEEKARRELIKQEYLRRKQ-Q 1350
+RK E +Q+ E E +L+R E RK EE+++R +EE++ RR+ +++ +Q +
Sbjct: 1722 ERKFREEEQLRQETEQE-QLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLR 1780
Query: 1351 QILEEQGLGKPKSKPKKPRPKSVHRE 1376
Q EEQ L +S K + + +E
Sbjct: 1781 QEREEQQLRSQESDRKFREEEQLRQE 1806
Score = 31.6 bits (70), Expect = 6.4
Identities = 23/93 (24%), Positives = 53/93 (56%), Gaps = 15/93 (16%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRK--AEEARVRKQQLEAEVELKRDEARRKAEEDRVRK- 1330
+D + E+E +R +++RK EE ++R+Q+LE + + ++ R++ E++++R+
Sbjct: 1689 RDRKFREEEQQLRRQ----ERERKFLQEEQQLRRQELERKFR-EEEQLRQETEQEQLRRQ 1743
Query: 1331 -------EEEKARRELIKQEYLRRKQQQILEEQ 1356
EEE+ R E +Q+ R+++ + E+
Sbjct: 1744 ERYRKILEEEQLRPEREEQQLRRQERDRKFREE 1776
>gi|134152708 arginine and glutamate rich 1 [Homo sapiens]
Length = 273
Score = 52.4 bits (124), Expect = 4e-06
Identities = 34/96 (35%), Positives = 59/96 (61%), Gaps = 5/96 (5%)
Query: 1276 EQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVE---LKRDEARRKAEEDRVR--K 1330
E++ +EL ++R A L Q+ + EE R ++++LE +E K EA+ K E+++R +
Sbjct: 169 EKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVE 228
Query: 1331 EEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPK 1366
E+ K E +K E R++QQ+ ++ LGK KS+PK
Sbjct: 229 EQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPK 264
Score = 39.3 bits (90), Expect = 0.031
Identities = 36/133 (27%), Positives = 67/133 (50%), Gaps = 16/133 (12%)
Query: 1275 DEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDE--ARRKAEEDRVRKEE 1332
++QK E+E +K+A F ++QRK + + ++ +E E + +E A+R EE RK+E
Sbjct: 97 EKQKREEE--EKKAEF--ERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDE 152
Query: 1333 EKARRELIK--QEYLRRKQQQILEE------QGLGKPKSKPKKPRPKSVHREESCSDSGT 1384
RE+++ +E R ++Q+LEE L K++ ++ R K E ++
Sbjct: 153 --IEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNR 210
Query: 1385 KCSSTPDNLSRTQ 1397
K + L+ Q
Sbjct: 211 KIAEAQAKLAEEQ 223
Score = 37.7 bits (86), Expect = 0.090
Identities = 31/91 (34%), Positives = 51/91 (56%), Gaps = 11/91 (12%)
Query: 1277 QKAEDELAKKRAAFLLKQQRKAEEA-RVRKQQLEAEVELKRDE--ARRKA--EEDRVRKE 1331
++ E+EL K++ + R+ EEA R+ ++QL E+E +R A +KA EE+R ++E
Sbjct: 140 KRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKRE 199
Query: 1332 E------EKARRELIKQEYLRRKQQQILEEQ 1356
E E R+ Q L +Q +I+EEQ
Sbjct: 200 ELERILEENNRKIAEAQAKLAEEQLRIVEEQ 230
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 52.0 bits (123), Expect = 5e-06
Identities = 38/100 (38%), Positives = 56/100 (56%), Gaps = 18/100 (18%)
Query: 1276 EQKAEDELAKKRAAFLLKQQRKAEEAR------VRKQQLEAEVELKRDEARRKAEEDRVR 1329
E++ E K++ L +QQR+ EAR R+++ E + L+ E RRK EE+R R
Sbjct: 394 ERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRR 453
Query: 1330 KEEEKARRELIKQEYLRRK-----------QQQILEEQGL 1358
EEEK R E +QEY+RR+ QQQ+L+EQ +
Sbjct: 454 AEEEKRRVER-EQEYIRRQLEEEQRHLEVLQQQLLQEQAM 492
Score = 41.6 bits (96), Expect = 0.006
Identities = 21/83 (25%), Positives = 51/83 (61%), Gaps = 2/83 (2%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEE 1333
+++Q E E K++ L ++Q++ E+ + ++++LE + +R+ R++ E R R++EE
Sbjct: 377 QEQQLREQEEYKRQ--LLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEE 434
Query: 1334 KARRELIKQEYLRRKQQQILEEQ 1356
K R E +++ ++++ EE+
Sbjct: 435 KRRLEELERRRKEEEERRRAEEE 457
Score = 38.5 bits (88), Expect = 0.053
Identities = 28/139 (20%), Positives = 68/139 (48%), Gaps = 11/139 (7%)
Query: 1242 KAPDEDGE---LVSLDGSADLVSEGDQKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKA 1298
+ P+++GE +V++ G + L + F ++ E A +R L +QQ +
Sbjct: 332 EVPEQEGEPSSIVNVPGESTLRRD--------FLRLQQENKERSEALRRQQLLQEQQLRE 383
Query: 1299 EEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGL 1358
+E R+ E + +++ + +R+ E++ R+E E R++ +Q +++++ LEE
Sbjct: 384 QEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELER 443
Query: 1359 GKPKSKPKKPRPKSVHREE 1377
+ + + ++ + R E
Sbjct: 444 RRKEEEERRRAEEEKRRVE 462
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sapiens]
Length = 1293
Score = 50.8 bits (120), Expect = 1e-05
Identities = 48/198 (24%), Positives = 99/198 (50%), Gaps = 9/198 (4%)
Query: 1224 EEPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSEGDQKPGVGFFFKDEQKAEDEL 1283
EE R + ++ + + E+ EL L + +Q+ + ++E++ + E
Sbjct: 753 EELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEE 812
Query: 1284 AKKRAAFLLKQQ--RKAEEARVRKQQLE-AEVELKRDEARRKAEEDRVRKEEEKARRELI 1340
A +R +++ R+ +E +RKQ+ E A+ + +EA+R+ EE+R+R EEE AR
Sbjct: 813 ALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR-H 871
Query: 1341 KQEYLRRKQQQILEEQGLGKPKSKPKKP--RPKSVHREESCSDSGTKCSST---PDNLSR 1395
++E +RK+ ++ ++ L + + + ++ R + +++ + SST N +
Sbjct: 872 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTA 931
Query: 1396 TQSGSSLSLASAATTEPE 1413
QS ++LSLA E E
Sbjct: 932 CQSQATLSLAEIQKLEEE 949
Score = 48.5 bits (114), Expect = 5e-05
Identities = 28/74 (37%), Positives = 46/74 (62%), Gaps = 11/74 (14%)
Query: 1292 LKQQRKAEEARVRKQQLEAEVELKRDEARRKAEED---------RVRKEEEKARRELIKQ 1342
L+Q KA+ A++ +++ EAE+ KR+E RK +E+ R ++EEE+ RRE ++
Sbjct: 720 LQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE--EE 777
Query: 1343 EYLRRKQQQILEEQ 1356
E RRKQ++ L Q
Sbjct: 778 ELARRKQEEALRRQ 791
Score = 47.4 bits (111), Expect = 1e-04
Identities = 29/97 (29%), Positives = 55/97 (56%), Gaps = 19/97 (19%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQ--------------RKAEEARVRKQQLEAEVELKRDEA 1319
++E+K ++EL +++ L +QQ RK EEA R+++ E + +R+E
Sbjct: 746 EEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEE 805
Query: 1320 RRKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQ 1356
R+ +E+ +R+ EE+ R +E RRKQ+++L +Q
Sbjct: 806 ERQQQEEALRRLEERRR-----EEEERRKQEELLRKQ 837
Score = 43.1 bits (100), Expect = 0.002
Identities = 29/75 (38%), Positives = 53/75 (70%), Gaps = 7/75 (9%)
Query: 1282 ELAKKRAAFLLKQQRKAE-EARVRKQQLEAEVELKRDEA---RRKAEEDRVRKEEEK-AR 1336
+L K +AA L +++R+AE A+ +++ + + EL+R + RR+ EE+R R+EEE+ AR
Sbjct: 722 QLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELAR 781
Query: 1337 RELIKQEYLRRKQQQ 1351
R+ ++E LRR+++Q
Sbjct: 782 RK--QEEALRRQREQ 794
Score = 42.4 bits (98), Expect = 0.004
Identities = 25/82 (30%), Positives = 49/82 (59%), Gaps = 5/82 (6%)
Query: 1275 DEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEK 1334
++++ E E+ KR +++RK +E +R+QQ E + +E +R+ EE+ R+++E+
Sbjct: 732 EQERREAEMRAKRE----EEERKRQE-ELRRQQEEILRRQQEEERKRREEEELARRKQEE 786
Query: 1335 ARRELIKQEYLRRKQQQILEEQ 1356
A R +QE R+Q++ E Q
Sbjct: 787 ALRRQREQEIALRRQREEEERQ 808
Score = 32.3 bits (72), Expect = 3.8
Identities = 40/204 (19%), Positives = 87/204 (42%), Gaps = 12/204 (5%)
Query: 856 RQKREQSPSQHGKDPASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAF 915
R++RE+ K +L ++ ++ + + + Q++ + L R+R + +
Sbjct: 771 RKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ 830
Query: 916 LHVVKKGKAEAAPPLRPEHFAKEYSQHN----GEDCGDAVSKTEDFLVK--EEQREELLH 969
+++K + EAA R E A+ + N E+ + E+ K E QR++ L
Sbjct: 831 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELM 890
Query: 970 EPQDVDKESLAFAQQHKAKDPVALHELERNKV-----ISAALLEDTVGEVVDVNECDLSI 1024
+ +E+L QQ + + +A +L + + A + ++ + +
Sbjct: 891 RQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER 950
Query: 1025 EK-LNETISTLQQAILKISQQQEQ 1047
E+ L E Q+ ++K QQQ+Q
Sbjct: 951 ERQLREEQRRQQRELMKALQQQQQ 974
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 50.8 bits (120), Expect = 1e-05
Identities = 48/198 (24%), Positives = 99/198 (50%), Gaps = 9/198 (4%)
Query: 1224 EEPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSEGDQKPGVGFFFKDEQKAEDEL 1283
EE R + ++ + + E+ EL L + +Q+ + ++E++ + E
Sbjct: 780 EELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEE 839
Query: 1284 AKKRAAFLLKQQ--RKAEEARVRKQQLE-AEVELKRDEARRKAEEDRVRKEEEKARRELI 1340
A +R +++ R+ +E +RKQ+ E A+ + +EA+R+ EE+R+R EEE AR
Sbjct: 840 ALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR-H 898
Query: 1341 KQEYLRRKQQQILEEQGLGKPKSKPKKP--RPKSVHREESCSDSGTKCSST---PDNLSR 1395
++E +RK+ ++ ++ L + + + ++ R + +++ + SST N +
Sbjct: 899 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTA 958
Query: 1396 TQSGSSLSLASAATTEPE 1413
QS ++LSLA E E
Sbjct: 959 CQSQATLSLAEIQKLEEE 976
Score = 48.5 bits (114), Expect = 5e-05
Identities = 28/74 (37%), Positives = 46/74 (62%), Gaps = 11/74 (14%)
Query: 1292 LKQQRKAEEARVRKQQLEAEVELKRDEARRKAEED---------RVRKEEEKARRELIKQ 1342
L+Q KA+ A++ +++ EAE+ KR+E RK +E+ R ++EEE+ RRE ++
Sbjct: 747 LQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE--EE 804
Query: 1343 EYLRRKQQQILEEQ 1356
E RRKQ++ L Q
Sbjct: 805 ELARRKQEEALRRQ 818
Score = 47.4 bits (111), Expect = 1e-04
Identities = 29/97 (29%), Positives = 55/97 (56%), Gaps = 19/97 (19%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQ--------------RKAEEARVRKQQLEAEVELKRDEA 1319
++E+K ++EL +++ L +QQ RK EEA R+++ E + +R+E
Sbjct: 773 EEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEE 832
Query: 1320 RRKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQ 1356
R+ +E+ +R+ EE+ R +E RRKQ+++L +Q
Sbjct: 833 ERQQQEEALRRLEERRR-----EEEERRKQEELLRKQ 864
Score = 43.1 bits (100), Expect = 0.002
Identities = 29/75 (38%), Positives = 53/75 (70%), Gaps = 7/75 (9%)
Query: 1282 ELAKKRAAFLLKQQRKAE-EARVRKQQLEAEVELKRDEA---RRKAEEDRVRKEEEK-AR 1336
+L K +AA L +++R+AE A+ +++ + + EL+R + RR+ EE+R R+EEE+ AR
Sbjct: 749 QLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELAR 808
Query: 1337 RELIKQEYLRRKQQQ 1351
R+ ++E LRR+++Q
Sbjct: 809 RK--QEEALRRQREQ 821
Score = 42.4 bits (98), Expect = 0.004
Identities = 25/82 (30%), Positives = 49/82 (59%), Gaps = 5/82 (6%)
Query: 1275 DEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEK 1334
++++ E E+ KR +++RK +E +R+QQ E + +E +R+ EE+ R+++E+
Sbjct: 759 EQERREAEMRAKRE----EEERKRQE-ELRRQQEEILRRQQEEERKRREEEELARRKQEE 813
Query: 1335 ARRELIKQEYLRRKQQQILEEQ 1356
A R +QE R+Q++ E Q
Sbjct: 814 ALRRQREQEIALRRQREEEERQ 835
Score = 32.3 bits (72), Expect = 3.8
Identities = 40/204 (19%), Positives = 87/204 (42%), Gaps = 12/204 (5%)
Query: 856 RQKREQSPSQHGKDPASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAF 915
R++RE+ K +L ++ ++ + + + Q++ + L R+R + +
Sbjct: 798 RKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ 857
Query: 916 LHVVKKGKAEAAPPLRPEHFAKEYSQHN----GEDCGDAVSKTEDFLVK--EEQREELLH 969
+++K + EAA R E A+ + N E+ + E+ K E QR++ L
Sbjct: 858 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELM 917
Query: 970 EPQDVDKESLAFAQQHKAKDPVALHELERNKV-----ISAALLEDTVGEVVDVNECDLSI 1024
+ +E+L QQ + + +A +L + + A + ++ + +
Sbjct: 918 RQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER 977
Query: 1025 EK-LNETISTLQQAILKISQQQEQ 1047
E+ L E Q+ ++K QQQ+Q
Sbjct: 978 ERQLREEQRRQQRELMKALQQQQQ 1001
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 50.8 bits (120), Expect = 1e-05
Identities = 48/198 (24%), Positives = 99/198 (50%), Gaps = 9/198 (4%)
Query: 1224 EEPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSEGDQKPGVGFFFKDEQKAEDEL 1283
EE R + ++ + + E+ EL L + +Q+ + ++E++ + E
Sbjct: 759 EELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEE 818
Query: 1284 AKKRAAFLLKQQ--RKAEEARVRKQQLE-AEVELKRDEARRKAEEDRVRKEEEKARRELI 1340
A +R +++ R+ +E +RKQ+ E A+ + +EA+R+ EE+R+R EEE AR
Sbjct: 819 ALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR-H 877
Query: 1341 KQEYLRRKQQQILEEQGLGKPKSKPKKP--RPKSVHREESCSDSGTKCSST---PDNLSR 1395
++E +RK+ ++ ++ L + + + ++ R + +++ + SST N +
Sbjct: 878 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTA 937
Query: 1396 TQSGSSLSLASAATTEPE 1413
QS ++LSLA E E
Sbjct: 938 CQSQATLSLAEIQKLEEE 955
Score = 48.5 bits (114), Expect = 5e-05
Identities = 28/74 (37%), Positives = 46/74 (62%), Gaps = 11/74 (14%)
Query: 1292 LKQQRKAEEARVRKQQLEAEVELKRDEARRKAEED---------RVRKEEEKARRELIKQ 1342
L+Q KA+ A++ +++ EAE+ KR+E RK +E+ R ++EEE+ RRE ++
Sbjct: 726 LQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE--EE 783
Query: 1343 EYLRRKQQQILEEQ 1356
E RRKQ++ L Q
Sbjct: 784 ELARRKQEEALRRQ 797
Score = 47.4 bits (111), Expect = 1e-04
Identities = 29/97 (29%), Positives = 55/97 (56%), Gaps = 19/97 (19%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQ--------------RKAEEARVRKQQLEAEVELKRDEA 1319
++E+K ++EL +++ L +QQ RK EEA R+++ E + +R+E
Sbjct: 752 EEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEE 811
Query: 1320 RRKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQ 1356
R+ +E+ +R+ EE+ R +E RRKQ+++L +Q
Sbjct: 812 ERQQQEEALRRLEERRR-----EEEERRKQEELLRKQ 843
Score = 43.1 bits (100), Expect = 0.002
Identities = 29/75 (38%), Positives = 53/75 (70%), Gaps = 7/75 (9%)
Query: 1282 ELAKKRAAFLLKQQRKAE-EARVRKQQLEAEVELKRDEA---RRKAEEDRVRKEEEK-AR 1336
+L K +AA L +++R+AE A+ +++ + + EL+R + RR+ EE+R R+EEE+ AR
Sbjct: 728 QLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELAR 787
Query: 1337 RELIKQEYLRRKQQQ 1351
R+ ++E LRR+++Q
Sbjct: 788 RK--QEEALRRQREQ 800
Score = 42.4 bits (98), Expect = 0.004
Identities = 25/82 (30%), Positives = 49/82 (59%), Gaps = 5/82 (6%)
Query: 1275 DEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEK 1334
++++ E E+ KR +++RK +E +R+QQ E + +E +R+ EE+ R+++E+
Sbjct: 738 EQERREAEMRAKRE----EEERKRQE-ELRRQQEEILRRQQEEERKRREEEELARRKQEE 792
Query: 1335 ARRELIKQEYLRRKQQQILEEQ 1356
A R +QE R+Q++ E Q
Sbjct: 793 ALRRQREQEIALRRQREEEERQ 814
Score = 32.3 bits (72), Expect = 3.8
Identities = 40/204 (19%), Positives = 87/204 (42%), Gaps = 12/204 (5%)
Query: 856 RQKREQSPSQHGKDPASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAF 915
R++RE+ K +L ++ ++ + + + Q++ + L R+R + +
Sbjct: 777 RKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ 836
Query: 916 LHVVKKGKAEAAPPLRPEHFAKEYSQHN----GEDCGDAVSKTEDFLVK--EEQREELLH 969
+++K + EAA R E A+ + N E+ + E+ K E QR++ L
Sbjct: 837 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELM 896
Query: 970 EPQDVDKESLAFAQQHKAKDPVALHELERNKV-----ISAALLEDTVGEVVDVNECDLSI 1024
+ +E+L QQ + + +A +L + + A + ++ + +
Sbjct: 897 RQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER 956
Query: 1025 EK-LNETISTLQQAILKISQQQEQ 1047
E+ L E Q+ ++K QQQ+Q
Sbjct: 957 ERQLREEQRRQQRELMKALQQQQQ 980
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 50.8 bits (120), Expect = 1e-05
Identities = 48/198 (24%), Positives = 99/198 (50%), Gaps = 9/198 (4%)
Query: 1224 EEPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSEGDQKPGVGFFFKDEQKAEDEL 1283
EE R + ++ + + E+ EL L + +Q+ + ++E++ + E
Sbjct: 759 EELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEE 818
Query: 1284 AKKRAAFLLKQQ--RKAEEARVRKQQLE-AEVELKRDEARRKAEEDRVRKEEEKARRELI 1340
A +R +++ R+ +E +RKQ+ E A+ + +EA+R+ EE+R+R EEE AR
Sbjct: 819 ALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR-H 877
Query: 1341 KQEYLRRKQQQILEEQGLGKPKSKPKKP--RPKSVHREESCSDSGTKCSST---PDNLSR 1395
++E +RK+ ++ ++ L + + + ++ R + +++ + SST N +
Sbjct: 878 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTA 937
Query: 1396 TQSGSSLSLASAATTEPE 1413
QS ++LSLA E E
Sbjct: 938 CQSQATLSLAEIQKLEEE 955
Score = 48.5 bits (114), Expect = 5e-05
Identities = 28/74 (37%), Positives = 46/74 (62%), Gaps = 11/74 (14%)
Query: 1292 LKQQRKAEEARVRKQQLEAEVELKRDEARRKAEED---------RVRKEEEKARRELIKQ 1342
L+Q KA+ A++ +++ EAE+ KR+E RK +E+ R ++EEE+ RRE ++
Sbjct: 726 LQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE--EE 783
Query: 1343 EYLRRKQQQILEEQ 1356
E RRKQ++ L Q
Sbjct: 784 ELARRKQEEALRRQ 797
Score = 47.4 bits (111), Expect = 1e-04
Identities = 29/97 (29%), Positives = 55/97 (56%), Gaps = 19/97 (19%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQ--------------RKAEEARVRKQQLEAEVELKRDEA 1319
++E+K ++EL +++ L +QQ RK EEA R+++ E + +R+E
Sbjct: 752 EEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEE 811
Query: 1320 RRKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQ 1356
R+ +E+ +R+ EE+ R +E RRKQ+++L +Q
Sbjct: 812 ERQQQEEALRRLEERRR-----EEEERRKQEELLRKQ 843
Score = 43.1 bits (100), Expect = 0.002
Identities = 29/75 (38%), Positives = 53/75 (70%), Gaps = 7/75 (9%)
Query: 1282 ELAKKRAAFLLKQQRKAE-EARVRKQQLEAEVELKRDEA---RRKAEEDRVRKEEEK-AR 1336
+L K +AA L +++R+AE A+ +++ + + EL+R + RR+ EE+R R+EEE+ AR
Sbjct: 728 QLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELAR 787
Query: 1337 RELIKQEYLRRKQQQ 1351
R+ ++E LRR+++Q
Sbjct: 788 RK--QEEALRRQREQ 800
Score = 42.4 bits (98), Expect = 0.004
Identities = 25/82 (30%), Positives = 49/82 (59%), Gaps = 5/82 (6%)
Query: 1275 DEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEK 1334
++++ E E+ KR +++RK +E +R+QQ E + +E +R+ EE+ R+++E+
Sbjct: 738 EQERREAEMRAKRE----EEERKRQE-ELRRQQEEILRRQQEEERKRREEEELARRKQEE 792
Query: 1335 ARRELIKQEYLRRKQQQILEEQ 1356
A R +QE R+Q++ E Q
Sbjct: 793 ALRRQREQEIALRRQREEEERQ 814
Score = 32.3 bits (72), Expect = 3.8
Identities = 40/204 (19%), Positives = 87/204 (42%), Gaps = 12/204 (5%)
Query: 856 RQKREQSPSQHGKDPASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAF 915
R++RE+ K +L ++ ++ + + + Q++ + L R+R + +
Sbjct: 777 RKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ 836
Query: 916 LHVVKKGKAEAAPPLRPEHFAKEYSQHN----GEDCGDAVSKTEDFLVK--EEQREELLH 969
+++K + EAA R E A+ + N E+ + E+ K E QR++ L
Sbjct: 837 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELM 896
Query: 970 EPQDVDKESLAFAQQHKAKDPVALHELERNKV-----ISAALLEDTVGEVVDVNECDLSI 1024
+ +E+L QQ + + +A +L + + A + ++ + +
Sbjct: 897 RQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER 956
Query: 1025 EK-LNETISTLQQAILKISQQQEQ 1047
E+ L E Q+ ++K QQQ+Q
Sbjct: 957 ERQLREEQRRQQRELMKALQQQQQ 980
>gi|15826852 acyl-Coenzyme A binding domain containing 3 [Homo
sapiens]
Length = 528
Score = 50.8 bits (120), Expect = 1e-05
Identities = 27/59 (45%), Positives = 43/59 (72%), Gaps = 2/59 (3%)
Query: 1293 KQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEKARRELIKQEYLRRKQQQ 1351
+++RK EE R R+++ E E K +E RR+ EE+R+R+EEE+ RR I++E LR +QQ+
Sbjct: 187 EKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRR--IEEERLRLEQQK 243
Score = 40.4 bits (93), Expect = 0.014
Identities = 25/74 (33%), Positives = 40/74 (54%)
Query: 1278 KAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEKARR 1337
K E E +K+ +++R+ EE R R Q+ E + + +E R+ EE+R R EEE+ R
Sbjct: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
Query: 1338 ELIKQEYLRRKQQQ 1351
E KQ+ + Q
Sbjct: 240 EQQKQQIMAALNSQ 253
Score = 38.1 bits (87), Expect = 0.069
Identities = 25/61 (40%), Positives = 40/61 (65%), Gaps = 7/61 (11%)
Query: 1309 EAEVELKRDEARRKAEED---RVRKEEEKARRELIKQEYLRRKQQQ--ILEEQGLGKPKS 1363
E E + K +E RR+ EE+ R++KEEEK RRE ++E LRR++++ +EE+ L +
Sbjct: 185 EQEKKRKEEEERRRREEEERERLQKEEEKRRRE--EEERLRREEEERRRIEEERLRLEQQ 242
Query: 1364 K 1364
K
Sbjct: 243 K 243
>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapiens]
Length = 1341
Score = 49.7 bits (117), Expect = 2e-05
Identities = 78/346 (22%), Positives = 141/346 (40%), Gaps = 40/346 (11%)
Query: 1154 LEPSGDPHGKCLFDSYRLHDESNQRTLTLSSSKDANILSEQMSLKEVLDASVKEVGSSSS 1213
L+ PH +S + S + K +L +++ + A ++E + S
Sbjct: 111 LQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESE 170
Query: 1214 D-VSGKESVPVEEPLRSRASLIEVDLS-DLKAPDEDGELVSLDGSADLVSEGDQKPGVGF 1271
D + E V P ++SL +L +P + + G +D D+KP G
Sbjct: 171 DEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSD-----DEKPRKG- 224
Query: 1272 FFKDEQKAEDELAKKRAAFLLKQQRKAEEAR-----VRKQQLEAEVELKRDEARRKAEED 1326
++ + + RAA L + + AEE R ++ A+ LK +E + EE+
Sbjct: 225 -----ERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEE 279
Query: 1327 RVRKEEEKARRELIKQEYLRRKQQQIL---EEQGLGKPKSKPKK---PRPKSVHREESCS 1380
EEE+ E + ++ IL +E+G P+ KP++ RPK+ +E+
Sbjct: 280 EEDDEEEEG-----DDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVL 334
Query: 1381 DSGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVESMEALPILSRNPS- 1439
+ G + + + + ++ TT P + ++S + L S++PS
Sbjct: 335 ERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLE-----EEEREIKSSQGLKEKSKSPSP 389
Query: 1440 -RSTDRDWETASAAS---SLASVAEYTGPKLFKEPSSKSNKPIIHN 1481
R T+ D + AS + AS E P L KE SS P +H+
Sbjct: 390 PRLTE-DRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHS 434
Score = 38.5 bits (88), Expect = 0.053
Identities = 42/186 (22%), Positives = 78/186 (41%), Gaps = 24/186 (12%)
Query: 1275 DEQKAEDELAKKRAAFLLKQQRKAEEA--RVRKQQLEAEVELKRDEARRKAEEDR--VRK 1330
+E++ +DE K R A +LK+ ++ E RV+ +++ E R + + E R
Sbjct: 284 EEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRS 343
Query: 1331 EEEKARRELIKQEY---------LRRKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSD 1381
+EE + L +Q+ L ++++I QGL + P PR ++ S
Sbjct: 344 QEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKAS--- 400
Query: 1382 SGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVESME--ALPILSRNPS 1439
+ P+ + + L A++ P H + +E ME A P+L +
Sbjct: 401 ----LVALPEQTASEEETPPPLLTKEASSPPP--HPQLHSEEEIEPMEGPAPPVLIQLSP 454
Query: 1440 RSTDRD 1445
+TD D
Sbjct: 455 PNTDAD 460
Score = 37.7 bits (86), Expect = 0.090
Identities = 22/98 (22%), Positives = 54/98 (55%), Gaps = 1/98 (1%)
Query: 1293 KQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEKARRELIKQEYLRRKQQQI 1352
K+ +AE A+ R+++ + + E ++ E ++AE +R R+ E + RRE ++ R++++
Sbjct: 1237 KEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERE 1296
Query: 1353 LEEQGLGKPKSKPKKPRPKSVHREESCSDSGTKCSSTP 1390
+ + + + ++ R + R ++ S ++ STP
Sbjct: 1297 RDRGDRDRDRERDRE-RGRERDRRDTKRHSRSRSRSTP 1333
Score = 31.6 bits (70), Expect = 6.4
Identities = 51/205 (24%), Positives = 79/205 (38%), Gaps = 38/205 (18%)
Query: 1110 PKDRPQGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLD----SALEPSGDPHGKCL 1165
P+ RP+ SRS T + R ASS+ R PG+ ++ + DP
Sbjct: 623 PRGRPKMGSRS---TSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQE 679
Query: 1166 FDSYRLHD----ESNQRTLTLSSSKDANILSEQMSLKEVLDASVKEVGSSSSDVSGKESV 1221
+ + E +RT T SSS A LS+ S ++ + ++ S +E+
Sbjct: 680 VATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAE 739
Query: 1222 PVEEPLRSRASLIEVDLSDLKAPD------EDGELVSLDGS---------------ADLV 1260
P P ++ E S L + E+ E V++D S AD V
Sbjct: 740 P---PAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQV 796
Query: 1261 SEGDQKPGVGFFFKDEQKAEDELAK 1285
S D+ G +DE+K E L K
Sbjct: 797 SNDDRPEG---SVEDEEKKESSLPK 818
Score = 31.6 bits (70), Expect = 6.4
Identities = 24/85 (28%), Positives = 41/85 (48%), Gaps = 11/85 (12%)
Query: 1293 KQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEKARRELIKQEYLRRKQQQI 1352
+ +++ +E VR+Q E E E++R E R ++E + R + + R + RRK+
Sbjct: 1132 RAEQREQERAVREQWAEREREMERRE-RTRSEREWDRDKVREGPRSRSRSRDRRRKE--- 1187
Query: 1353 LEEQGLGKPKSKPKKPRPKSVHREE 1377
+ KSK KK K +EE
Sbjct: 1188 -------RAKSKEKKSEKKEKAQEE 1205
Score = 31.6 bits (70), Expect = 6.4
Identities = 26/134 (19%), Positives = 58/134 (43%), Gaps = 8/134 (5%)
Query: 1276 EQKAEDELAKKRAAFLLKQQRKAE--------EARVRKQQLEAEVELKRDEARRKAEEDR 1327
++KA++E K L ++ + A ++++ +++ E K E RRK +E+
Sbjct: 1199 KEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEE 1258
Query: 1328 VRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSDSGTKCS 1387
+KE EK ++ R K+++ E+ + + + + + RE +
Sbjct: 1259 EQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDR 1318
Query: 1388 STPDNLSRTQSGSS 1401
SR++S S+
Sbjct: 1319 RDTKRHSRSRSRST 1332
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 49.7 bits (117), Expect = 2e-05
Identities = 53/214 (24%), Positives = 103/214 (48%), Gaps = 34/214 (15%)
Query: 1201 LDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSD---LKAPDED-------GEL 1250
+ V+ V +S SDVS P+ +P+ S ++ ++D + +K P+E
Sbjct: 377 ISTPVEPVAASKSDVS-----PIIQPVPSIKNVPQIDRTKKPAVKLPEEHRIKSESTNHE 431
Query: 1251 VSLDGSADLVSEGDQKPGV---GFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQ 1307
S ++ + KP V DE+KA A L+++ ++ +E R R+Q+
Sbjct: 432 QQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKAR---IHAETALLMEKNKQEKELRERQQE 488
Query: 1308 LEAEVELKRDEARRKA------EEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKP 1361
+ E +L+++E +KA EE+ + ++++KA+ E+ K+E + K++ GK
Sbjct: 489 EQKE-KLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKETSAKRGKE 547
Query: 1362 KSKPKKPRPKSVHR----EESCSDSGTKCSSTPD 1391
+ K+ + KS H ++S D G +C TP+
Sbjct: 548 ITGVKR-QSKSEHETSDAKKSVEDRGKRC-PTPE 579
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 49.7 bits (117), Expect = 2e-05
Identities = 53/214 (24%), Positives = 103/214 (48%), Gaps = 34/214 (15%)
Query: 1201 LDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSD---LKAPDED-------GEL 1250
+ V+ V +S SDVS P+ +P+ S ++ ++D + +K P+E
Sbjct: 377 ISTPVEPVAASKSDVS-----PIIQPVPSIKNVPQIDRTKKPAVKLPEEHRIKSESTNHE 431
Query: 1251 VSLDGSADLVSEGDQKPGV---GFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQ 1307
S ++ + KP V DE+KA A L+++ ++ +E R R+Q+
Sbjct: 432 QQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKAR---IHAETALLMEKNKQEKELRERQQE 488
Query: 1308 LEAEVELKRDEARRKA------EEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKP 1361
+ E +L+++E +KA EE+ + ++++KA+ E+ K+E + K++ GK
Sbjct: 489 EQKE-KLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKETSAKRGKE 547
Query: 1362 KSKPKKPRPKSVHR----EESCSDSGTKCSSTPD 1391
+ K+ + KS H ++S D G +C TP+
Sbjct: 548 ITGVKR-QSKSEHETSDAKKSVEDRGKRC-PTPE 579
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 49.7 bits (117), Expect = 2e-05
Identities = 53/214 (24%), Positives = 103/214 (48%), Gaps = 34/214 (15%)
Query: 1201 LDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSD---LKAPDED-------GEL 1250
+ V+ V +S SDVS P+ +P+ S ++ ++D + +K P+E
Sbjct: 377 ISTPVEPVAASKSDVS-----PIIQPVPSIKNVPQIDRTKKPAVKLPEEHRIKSESTNHE 431
Query: 1251 VSLDGSADLVSEGDQKPGV---GFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQ 1307
S ++ + KP V DE+KA A L+++ ++ +E R R+Q+
Sbjct: 432 QQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKAR---IHAETALLMEKNKQEKELRERQQE 488
Query: 1308 LEAEVELKRDEARRKA------EEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKP 1361
+ E +L+++E +KA EE+ + ++++KA+ E+ K+E + K++ GK
Sbjct: 489 EQKE-KLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKETSAKRGKE 547
Query: 1362 KSKPKKPRPKSVHR----EESCSDSGTKCSSTPD 1391
+ K+ + KS H ++S D G +C TP+
Sbjct: 548 ITGVKR-QSKSEHETSDAKKSVEDRGKRC-PTPE 579
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 49.3 bits (116), Expect = 3e-05
Identities = 58/272 (21%), Positives = 117/272 (43%), Gaps = 32/272 (11%)
Query: 1121 KTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSGDPHGKCLFDSYRLHDESNQRTL 1180
K P + + L P P + +L+P+ P S + ES + T
Sbjct: 512 KQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKP-----LPSKSVRKESKEETP 566
Query: 1181 TLSSSKDANILSEQMSLKEVLDASVKEVGSSSS-DVSGKESVPVEEPLRSRASLIEVDLS 1239
++ + S ++V+ K + + + V+ KE EEP +A + E +
Sbjct: 567 EVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQAT 626
Query: 1240 DLKAPDEDGELVSLDGSADLVSEGDQKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKAE 1299
D+K + V + V D+K ++++K + E+AKK +K++ K +
Sbjct: 627 DVKPKAAKEKTVKKETK---VKPEDKK-------EEKEKPKKEVAKKEDKTPIKKEEKPK 676
Query: 1300 EARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLG 1359
+ V+K E + E+K++E + +E + ++ ++E+ K+E K+++ ++ +
Sbjct: 677 KEEVKK---EVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIK 733
Query: 1360 K----------PKSKPKKP---RPKSVHREES 1378
K P S+ KKP +PK +EES
Sbjct: 734 KLPKDAKKSSTPLSEAKKPAALKPKVPKKEES 765
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 48.5 bits (114), Expect = 5e-05
Identities = 93/458 (20%), Positives = 178/458 (38%), Gaps = 75/458 (16%)
Query: 932 PEHFAKEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQDVDKESLAFAQQHK----- 986
P +++ + + D G+ S+ E+ + +++ L E + L ++ K
Sbjct: 339 PAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLS 398
Query: 987 ---AKDPVALHELE---RNKV----ISAALLEDTVGEVVDVNECDLSIEKLNETISTLQQ 1036
A DP + H L+ R+++ + +L +G + L IE +++ S+ +
Sbjct: 399 DSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDE 458
Query: 1037 AILKISQQQEQLLMKSPTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRLGQG 1096
K S+ E+ L SP +P + +Q P P G ++A LG+
Sbjct: 459 LQSKQSKGLEERL--SPPLP---HEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGED 513
Query: 1097 ------------RNSRSGRPAELKVPKDRPQ-------GSSRSKTPTP--SVETLPHLRP 1135
R PA + K++ G ++ P +V P + P
Sbjct: 514 SAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSP 573
Query: 1136 FPASSHPRTPTDPGLDSALEPSGDPHGKCLFDSYRLHDESNQRTLTLSSSKDANILSEQM 1195
S+ P P + ++AL+ + + L E +QR L S + L E++
Sbjct: 574 EVRSTEPVAPPEQLSEAALKAMEEAVAQVL--------EQDQRHLLESKQEKMQQLREKL 625
Query: 1196 SLKE---VLDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVS 1252
+E +L ++ S SS + EE R R +E L
Sbjct: 626 CQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMRE-------------EESQRLSW 672
Query: 1253 LDGSADLVSEGDQKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEV 1312
L ++ D+ D+ +AE E + ++ L+ Q+KAE A + ++ +
Sbjct: 673 LRAQVQSSTQADE---------DQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLE 723
Query: 1313 ELKRD-EARRKAEEDRVRKEEEKARRELIKQEYLRRKQ 1349
+LK + EA K+E+ + +EKA ++L +Q RK+
Sbjct: 724 QLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKE 761
Score = 38.1 bits (87), Expect = 0.069
Identities = 45/193 (23%), Positives = 86/193 (44%), Gaps = 39/193 (20%)
Query: 1193 EQMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDE---DGE 1249
EQ S E L +E V+ + PV +RS + AP E +
Sbjct: 541 EQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPV---------APPEQLSEAA 591
Query: 1250 LVSLDGSADLVSEGDQKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEA------RV 1303
L +++ + V E DQ+ + + Q+ ++L ++ +L+ ++ E++ R+
Sbjct: 592 LKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERL 651
Query: 1304 RKQQLEAEVELKRDEARR------------KAEEDRVRKEEE----KARRELIKQE---- 1343
+K E E ++ +E++R +A+ED++R E+E K R EL Q+
Sbjct: 652 QKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAER 711
Query: 1344 -YLRRKQQQILEE 1355
L +K +Q+LE+
Sbjct: 712 ASLEQKNRQMLEQ 724
Score = 33.9 bits (76), Expect = 1.3
Identities = 63/314 (20%), Positives = 117/314 (37%), Gaps = 54/314 (17%)
Query: 783 EDKDDASGRSSPCLSTASQMSSVSMASGSVKMTSFAERKLQRLNSCETKSSTSSSQKTTP 842
EDKDD SQ S + S K + E +L E ++ + T
Sbjct: 447 EDKDD------------SQSSQDELQS---KQSKGLEERLSPPLPHEERAQSPPRSLATE 491
Query: 843 DASESCPAPLTTWRQKREQSPSQHGKDPASLLASELVQLHMQLEEKRRAIEAQKKKMEAL 902
+ P W++ E G+D A+ L+ +QL +Q E+ A +K E
Sbjct: 492 EEPPQGPEGQPEWKEAEEL-----GEDSAASLS---LQLSLQREQAPSPPAACEKGKEQH 543
Query: 903 SARQRLKLGKAAFLHVVKKGKAEAAPPLRPE--------------------------HFA 936
S + L G+ +K PP+ PE
Sbjct: 544 SQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVL 603
Query: 937 KEYSQHNGEDCGDAVSKTEDFLVKEEQREEL-LHEPQDVDKESLAFAQQHKAKDPVAL-- 993
++ +H E + + + + L +EE+ E L LH+ ++ SL Q ++ A
Sbjct: 604 EQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMR 663
Query: 994 -HELERNKVISAALLEDTVGEVVDVN-ECDLSIEKLNETISTLQQAILKISQQQEQLLMK 1051
E +R + A + T + + E + S++KL E + + Q+A +Q+ + +++
Sbjct: 664 EEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLE 723
Query: 1052 SPTVPVPGSKNNSQ 1065
+ S+ + Q
Sbjct: 724 QLKEEIEASEKSEQ 737
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 48.5 bits (114), Expect = 5e-05
Identities = 55/225 (24%), Positives = 101/225 (44%), Gaps = 32/225 (14%)
Query: 1193 EQMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVS 1252
E+ L+++ + E G + EE + S + VD + A +E E +
Sbjct: 246 EKAKLRKLKEKEELETGKKDQSKQKESQRKFEE--ETVKSKVTVDTGVIPASEEKAETPT 303
Query: 1253 LDGSADLVSEGDQKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEV 1312
+A+ +EGD+K KD++K + E +K K+++K K EA
Sbjct: 304 ---AAEDDNEGDKKK------KDKKKKKGEKEEKE-----KEKKKGPSKATVKAMQEALA 349
Query: 1313 ELKRDEARRKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKS 1372
+LK +E R+K R+EEE+ +R +++ +RK+++ LE++ + K K K+
Sbjct: 350 KLKEEEERQK------REEEERIKR--LEELEAKRKEEERLEQEKRERKKQKEKE----- 396
Query: 1373 VHREESCSDSGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHS 1417
R+E G K + +R ++ ++L L A E S S
Sbjct: 397 --RKERLKKEG-KLLTKSQREARARAEATLKLLQAQGVEVPSKDS 438
Score = 33.5 bits (75), Expect = 1.7
Identities = 34/166 (20%), Positives = 76/166 (45%), Gaps = 18/166 (10%)
Query: 1293 KQQRKAEEAR---VRKQQLEAEVELKRDEARRKAEEDRVRKEEEKARRELIKQEYLRRKQ 1349
KQ+ K+E++ + L AE+E ++ ++ + +K++EK +++ + + L+ +
Sbjct: 4 KQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELE 63
Query: 1350 QQILEEQGLGKPKSKPKKPRPKSVHREESCS-------DSGTKCSSTPDNLSRTQSGSSL 1402
+ LE QG+ K + +P + EE S G K S ++ + S
Sbjct: 64 ELSLEAQGI-KADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDS- 121
Query: 1403 SLASAATTEPE-SVHSGGTPSQRVESMEALPILSRNPSRSTDRDWE 1447
S T +P+ ++SG S + LP ++ ++ +++ W+
Sbjct: 122 --KSKKTAKPKVEMYSG---SDDDDDFNKLPKKAKGKAQKSNKKWD 162
Score = 33.5 bits (75), Expect = 1.7
Identities = 45/233 (19%), Positives = 90/233 (38%), Gaps = 15/233 (6%)
Query: 1186 KDANILSE-QMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAP 1244
K+ +L++ Q + +A++K + + +V K+S+P + P+ D K P
Sbjct: 403 KEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYE-------DKKRKKIP 455
Query: 1245 D-----EDGELVSLDGSADLVSEG-DQKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKA 1298
E E + L + +++ +G +K + E++ + E A + +
Sbjct: 456 QQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEET 515
Query: 1299 EEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGL 1358
E+ K +E + + +E + EE+ EEE+ + + +++ +E+
Sbjct: 516 EKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDS 575
Query: 1359 GKPKSKPKKPRPKSVHREESCSDSGTKCSSTPDNLSRTQSGSSLSLASAATTE 1411
GK K K + S E D TK D R L + TE
Sbjct: 576 GKTLDK-KPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTE 627
Score = 31.6 bits (70), Expect = 6.4
Identities = 26/116 (22%), Positives = 54/116 (46%), Gaps = 8/116 (6%)
Query: 1273 FKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVEL-KRDEARRKAEEDRVRKE 1331
FK + A+ + KK +++R E+A++RK + + E+E K+D++++K + + +E
Sbjct: 223 FKIKTVAQKKAEKKERE---RKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEE 279
Query: 1332 EEKAR----RELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSDSG 1383
K++ +I + + E+ G K K KK + +E G
Sbjct: 280 TVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKG 335
>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
Length = 732
Score = 48.5 bits (114), Expect = 5e-05
Identities = 39/137 (28%), Positives = 72/137 (52%), Gaps = 18/137 (13%)
Query: 1275 DEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEE- 1333
D +A LA+KR L+++++ +E RV K++ + L+R+E +RKAEE+R+R EEE
Sbjct: 396 DAGEAAKILAEKRRQARLQKEQEEQE-RVEKEEQD---RLEREELKRKAEEERLRLEEEA 451
Query: 1334 -KARRELIKQEYLRRKQQ------------QILEEQGLGKPKSKPKKPRPKSVHREESCS 1380
K E +QE ++KQ+ + EE+ L K K + +K + +++ +
Sbjct: 452 RKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAA 511
Query: 1381 DSGTKCSSTPDNLSRTQ 1397
++ + + L R Q
Sbjct: 512 ETKAREVAEQMRLEREQ 528
Score = 44.3 bits (103), Expect = 0.001
Identities = 54/241 (22%), Positives = 99/241 (41%), Gaps = 47/241 (19%)
Query: 1275 DEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEK 1334
+E++ E AK++A L + K E+ + K +E + E +AR AE+ R+ +E+
Sbjct: 471 EEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIM 530
Query: 1335 ARRELIKQEYLRRKQQ--QILEEQGLGKPKSKPKKPRPKSVHREESCSDSGTKC----SS 1388
+ I+QE L RK++ +I++ + KK PK + C + TK
Sbjct: 531 LQ---IEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKKTKLVVPNKM 587
Query: 1389 TPDNLSRTQSGSSLSLASAATTEPESVHSGG---------------------TPSQRVES 1427
+ L+ Q + + A A T P+ + S G ++ V+S
Sbjct: 588 EINGLNTCQEVNGVDHA-APETYPQDIFSNGLKPAGGLIHLDALDGKSNSLDDSTEEVQS 646
Query: 1428 MEALPILSRN--------------PSRSTDRDWETASAASSLASVAEYTGPKLFKEPSSK 1473
M+ P+ P S D++ A +L + ++TGP F + SS+
Sbjct: 647 MDVSPVSKEELISIPEFSPVSEMIPGVSLDQN--GTGNARALQDLLDFTGPPTFPKRSSE 704
Query: 1474 S 1474
+
Sbjct: 705 N 705
Score = 37.7 bits (86), Expect = 0.090
Identities = 55/261 (21%), Positives = 102/261 (39%), Gaps = 29/261 (11%)
Query: 1109 VPKDRPQGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSGDPHGKCLFDS 1168
+PK RP SKT T + P P P P L P
Sbjct: 284 IPK-RPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAE------- 335
Query: 1169 YRLHDESNQRTLTLSSSKDANILSEQMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLR 1228
++SN+ + + A E+ K V+D E ++++ + S + +P
Sbjct: 336 ---KEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTA 392
Query: 1229 SRASLIEVDLSDLKAPDEDGELVSLDGSADLVSEGDQKPGVGFFFKDEQKA--EDELAKK 1286
A + L A L E +++ V K+EQ +EL +K
Sbjct: 393 GTTD----------AGEAAKILAEKRRQARLQKEQEEQERVE---KEEQDRLEREELKRK 439
Query: 1287 RAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEKARRELIKQEYLR 1346
L+ + +A + +++ E E + + E +RKA E+ RK EE+ L+K++ +
Sbjct: 440 AEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEEL---LLKEKQEQ 496
Query: 1347 RKQQQILEEQGLGKPKSKPKK 1367
KQ++ + E+ ++K ++
Sbjct: 497 EKQEKAMIEKQKEAAETKARE 517
Score = 33.5 bits (75), Expect = 1.7
Identities = 46/182 (25%), Positives = 72/182 (39%), Gaps = 25/182 (13%)
Query: 1285 KKRAAFLLKQQ-----RKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEKARREL 1339
+KRA ++Q RK EE R R+ Q A VE KR + ++R+EEE R E
Sbjct: 80 QKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQ--------KLREEEE--RLEA 129
Query: 1340 IKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSDSGTKCSSTPDNLSRTQSG 1399
+ + L R QQ L K K P ++C T S P +
Sbjct: 130 MMRRSLERTQQLEL------KKKYSWGAPLAIGPGGHDACDKLSTSTMSLPKPTEPPMNK 183
Query: 1400 SSLSLASAATTEPESVHSGGTPSQRVESMEAL-PILSRNPSRSTDRDWETASAASSLASV 1458
S A + P+ V R+ + L P +P+R+ ++ T+++ S V
Sbjct: 184 RLSSSTVAISYSPDRVFH---VCPRLAPLGPLNPSYKSSPTRNIEKKKATSTSTSGAGDV 240
Query: 1459 AE 1460
+
Sbjct: 241 GK 242
Score = 31.6 bits (70), Expect = 6.4
Identities = 23/71 (32%), Positives = 41/71 (57%), Gaps = 7/71 (9%)
Query: 1293 KQQRKAEEARVRKQQL----EAEVELKRDEARRKAE---EDRVRKEEEKARRELIKQEYL 1345
++QR A+E R +++ E ++ K+ AR + E E+R RK EE+ +RE K+ +
Sbjct: 53 ERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAV 112
Query: 1346 RRKQQQILEEQ 1356
K++Q L E+
Sbjct: 113 EEKRKQKLREE 123
Score = 31.2 bits (69), Expect = 8.4
Identities = 22/89 (24%), Positives = 47/89 (52%), Gaps = 13/89 (14%)
Query: 1270 GFFFKDEQK--AEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDR 1327
GF DE++ A++ ++ ++Q+ E+ + + Q E ++E E RK EE R
Sbjct: 47 GFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQME----ERWRKLEEQR 102
Query: 1328 VRKEEEKARRELIKQEYLRRKQQQILEEQ 1356
R+++++A E +++Q++ EE+
Sbjct: 103 QREDQKRAAVE-------EKRKQKLREEE 124
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 48.1 bits (113), Expect = 7e-05
Identities = 47/169 (27%), Positives = 81/169 (47%), Gaps = 16/169 (9%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARR------KAEEDR 1327
++E + E E + +A L+ + +AEE +K +AE E +++EA R KAEE
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 1328 VRKEEEKARRELIKQEYLRR--KQQQILEEQGLGKPKSKPKKPRPKSVHREE-------S 1378
VR + E A +EL KQ L QQ++ EQ L + +++ ++ + EE
Sbjct: 1684 VR-QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 1379 CSDSGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVES 1427
+ + K L++ ++ + LAS A E ES + QR+E+
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Score = 44.3 bits (103), Expect = 0.001
Identities = 137/672 (20%), Positives = 267/672 (39%), Gaps = 61/672 (9%)
Query: 880 QLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPEHFAKEY 939
Q+ + LE +R+ EA+ + A A + +L ++ + + A LR E +
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSL------QEEHVAVAQLREEAERRAQ 1615
Query: 940 SQHNGEDCGD-AVSKTEDFLVKEEQREELLHEPQDV-DKESLAFAQQHKAKDPVALHELE 997
Q E + A + E + +K + L + ++V ++SLA A+ K K+
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1675
Query: 998 RNKVISAALLEDTVGEVVDVNECDLSIEKLNETISTLQQAI-----LKISQQQEQLLMKS 1052
R K A+ + + E + L+ + ++ Q+ I + +QQ QLL +
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735
Query: 1053 -PTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRLGQGRNSRSGRPAELKVPK 1111
+ + + +++A + V +A +A + + +S + E + +
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1795
Query: 1112 DRP--QGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSGDPHGKCLFDSY 1169
R + ++R + + L A+ R + L L G+
Sbjct: 1796 FRELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEI 1854
Query: 1170 RLHDES--NQRTLTLSSSK--DANILSEQMSL-KEVLDASVKEVGSSSSDVSGKESVPVE 1224
L ++ N+R L+ + L EQ + K ++ + ++ +S ++ VE
Sbjct: 1855 ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1914
Query: 1225 EPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSE-GDQKPGVGFFFKDEQKAEDEL 1283
+ LR R +E ++ LKA E G A+L E G + + +++AE E
Sbjct: 1915 DTLRQRRQ-VEEEILALKASFEKAAA----GKAELELELGRIRSNAEDTLRSKEQAELEA 1969
Query: 1284 AKKR--AAFLLKQQRKAEE------------ARVRKQQLEAEVELKR--DEARRKAEEDR 1327
A++R AA +++R+AEE AR RK LE LK +EARR E
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE--- 2026
Query: 1328 VRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSD------ 1381
R E+E AR+ + QE +++ Q EE+ + ++ +++ +E+S D
Sbjct: 2027 -RAEQESARQLQLAQEAAQKRLQ--AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 1382 SGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGG--TPSQRVESMEALPILSRNPS 1439
+ ++ +R Q+ + + E E + R ++ A L +
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2143
Query: 1440 RSTDR--DWETASAASSLASVAEYTGPKLFKEPSSKSNKPIIHNAISHCCLAGKVNEPHK 1497
+ R E A+ A+ AE K F E + + K + ++ L + + K
Sbjct: 2144 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTTLRLQLEETDHQK 2202
Query: 1498 NSILEELEKCDA 1509
N + EEL++ A
Sbjct: 2203 NLLDEELQRLKA 2214
Score = 43.1 bits (100), Expect = 0.002
Identities = 46/170 (27%), Positives = 73/170 (42%), Gaps = 27/170 (15%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKR-------DEARRKAEED 1326
K EQ +DE+AK + +QQR+ ++ +Q+L A +E R + RRK EE
Sbjct: 2515 KLEQLFQDEVAKAQQ-LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2573
Query: 1327 RVRKEEEKARRELIKQEYLR-RKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSDSGTK 1385
+ +++ + + EL+ +E R R+Q Q+LEEQ R H EE +
Sbjct: 2574 QQLEQQRRQQEELLAEENQRLREQLQLLEEQ-----------HRAALAHSEEVTASQVAA 2622
Query: 1386 CSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVESMEALPILS 1435
+ P +G AA EPE G + ++ ILS
Sbjct: 2623 TKTLP-------NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2665
Score = 41.6 bits (96), Expect = 0.006
Identities = 120/643 (18%), Positives = 240/643 (37%), Gaps = 86/643 (13%)
Query: 755 EAHPVVFSRYIGEEESAKLQEDMKVKEHEDKDDASGRSSPCLSTASQM-----SSVSMAS 809
EA + + E +L ED + ++ A+ + +Q+ S +
Sbjct: 1851 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910
Query: 810 GSVKMTSFAERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTWRQKREQSPSQHGKD 869
G V+ T R+++ E + +S +K +E L R + + K+
Sbjct: 1911 GLVEDTLRQRRQVEE----EILALKASFEKAAAGKAE---LELELGRIRSNAEDTLRSKE 1963
Query: 870 PASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPP 929
A L A+ Q + EE+RR EA+++ ++L+A + + A L V++ KA+
Sbjct: 1964 QAELEAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 930 LRPEHFAKEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQDVDKESLAFAQQHKAKD 989
R A++ S + +A K Q EE H AFA Q K +
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQK-------RLQAEEKAH----------AFAVQQKEQ- 2063
Query: 990 PVALHELERNKVISAALLEDTVGEVVDVNECDLSIEKLNETISTLQQAILKISQQQEQLL 1049
EL++ ++L+ GE E+ + ++A Q +E
Sbjct: 2064 -----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR--VQAEREAAQSRRQVEEAER 2116
Query: 1050 MKSPTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRLGQGRNS----RSGRPA 1105
+K S + + +A ++A R Q + + A
Sbjct: 2117 LKQ-----------SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2165
Query: 1106 ELKVPKDRPQGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSGDPHGKC- 1164
E++ K + + R K T L+ + H + D L + + +
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNLLDEELQRLKAEATEAARQRS 2224
Query: 1165 -----LFDSYRLHDESNQRTLTLSSSKDANILSEQMSLKEVLDASVKEVGSSSSDVSGKE 1219
LF +E ++ + + A IL ++ + + L +++ + + + +
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA-RL 2283
Query: 1220 SVPVEEPLRSRASLIEVDLSDLKAPDED---------GELVSLDGSADLVSEGDQ--KPG 1268
SV +E R R L E DL+ +A E E L A+L+ + + +
Sbjct: 2284 SVAAQEAARLR-QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2342
Query: 1269 VGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVE--------LKRDEAR 1320
+D+++ +LA++ F QR E R R+ ++ AE E + R +AR
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGF----QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398
Query: 1321 RKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKS 1363
+ + R RK+ E+ +L + E +++ +++ + + +S
Sbjct: 2399 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441
Score = 35.4 bits (80), Expect = 0.45
Identities = 118/611 (19%), Positives = 238/611 (38%), Gaps = 89/611 (14%)
Query: 818 AERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTWRQKREQSPSQHGKDPASLLASE 877
AE ++Q+ S + + +K + E A + R+ RE++ + + LA E
Sbjct: 1986 AEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ--LAQE 2041
Query: 878 LVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPE-HFA 936
Q +Q EEK A Q+K+ E +Q L+ ++ + +G+AEAA E A
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQEL---QQTLQQEQSVLDQL--RGEAEAARRAAEEAEEA 2096
Query: 937 KEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQ--------DVDKESLAFAQQHKA- 987
+ ++ V + E E++ + + Q + ++E+ AQ +A
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2156
Query: 988 --KDPVALHELERNKVISAALLEDTVGEVVDVNECDLSIEK-------LNETI------- 1031
+ A E+E++K + L ++ L +E+ L+E +
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 1032 -------STLQQAILKISQQQEQLLMKSPTVPVPG------SKNNSQ---DHKVKAPVHF 1075
S +++ + + Q E+L + K+N+Q + +
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276
Query: 1076 VEPLSPTGVAGHRKAPRLGQGRNSRSGRPAEL--KVPKDRPQGSSRSKTPTPSVETLPHL 1133
E + VA ++A RL Q + L K+ K++ Q + E L
Sbjct: 2277 AEEAARLSVAA-QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335
Query: 1134 RPFPASSHPRTPTDPGLDSALEPSGDPHGKCLFDSYRLHDESNQRTLTLSSSKDA-NILS 1192
+ R D A + + + G R + QR L +S+ + +
Sbjct: 2336 KELAQEQARRLQEDKE-QMAQQLAEETQG-----FQRTLEAERQRQLEMSAEAERLKLRV 2389
Query: 1193 EQMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVS 1252
+MS + + ++ G++ E + + +L++ + D D E +
Sbjct: 2390 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2449
Query: 1253 LDGSADLVSEGD--QKPGVGFFFKDEQKA---EDELAKKRAAF----------LLKQQRK 1297
+ A+L E + Q+ K E+ +++L ++ A LL+++R
Sbjct: 2450 -EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508
Query: 1298 AEEARVRKQQL----EAEVELKRDEARR---KAEEDR---VRKEEEKARRELIKQEYLRR 1347
E+ + + +QL A+ + R+E +R + E++R V EE RR+ +E +RR
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 1348 KQQQI--LEEQ 1356
KQ+++ LE+Q
Sbjct: 2569 KQEELQQLEQQ 2579
Score = 33.1 bits (74), Expect = 2.2
Identities = 31/131 (23%), Positives = 61/131 (46%), Gaps = 13/131 (9%)
Query: 1205 VKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSEGD 1264
+K + + + +E + ++ R L EV+ A ++ +L A +E +
Sbjct: 1334 IKFISETLRRMEEEERLAEQQRAEERERLAEVEA----ALEKQRQLAEAHAQAKAQAERE 1389
Query: 1265 QKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKA--EEARVRKQQLEAEVELKRDEARRK 1322
K ++ E+ + ++ AA +QQ+++ EE + +Q EAE++ K +A
Sbjct: 1390 AKE------LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA-EA 1442
Query: 1323 AEEDRVRKEEE 1333
AE R+R EEE
Sbjct: 1443 AERSRLRIEEE 1453
Score = 32.3 bits (72), Expect = 3.8
Identities = 24/96 (25%), Positives = 44/96 (45%), Gaps = 7/96 (7%)
Query: 1320 RRKAEEDRVRKEEEKARRE-LIKQEYLRRKQQQILEEQGLGK------PKSKPKKPRPKS 1372
RR EE+R+ +++ RE L + E KQ+Q+ E K K ++ + +
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 1373 VHREESCSDSGTKCSSTPDNLSRTQSGSSLSLASAA 1408
V REE+ D+ + S + L + + S + + A
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1437
Score = 32.3 bits (72), Expect = 3.8
Identities = 47/206 (22%), Positives = 82/206 (39%), Gaps = 41/206 (19%)
Query: 1192 SEQMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELV 1251
S Q L+++ +S E+ + + E + R ++++ ++ + +GEL
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476
Query: 1252 SLDGSAD-------------------LVSEGDQKPGVGFFFKDEQKAEDELA--KKRAAF 1290
+L A+ + E +K KAE E A K+RA
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 1291 LLKQQR-KAEEARVRKQQLEAE----VELKRDEARRKAEEDRVRK--------------- 1330
L++ R +AEEA R +Q E E V++ + A+R AE + K
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 1331 EEEKARRELIKQEYLRRKQQQILEEQ 1356
+EE +++E RR QQQ E+
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAER 1622
Score = 32.0 bits (71), Expect = 4.9
Identities = 27/86 (31%), Positives = 49/86 (56%), Gaps = 11/86 (12%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAE-EARVRKQQLEAEVELK-RDEARRKAEEDRVRKE 1331
++E+ AE + A++R +R AE EA + KQ+ AE + + +A R+A+E + R +
Sbjct: 1346 EEERLAEQQRAEER-------ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 1332 EEKARRE--LIKQEYLRRKQQQILEE 1355
EE RRE + + +R Q+ L++
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQ 1424
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 48.1 bits (113), Expect = 7e-05
Identities = 47/169 (27%), Positives = 81/169 (47%), Gaps = 16/169 (9%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARR------KAEEDR 1327
++E + E E + +A L+ + +AEE +K +AE E +++EA R KAEE
Sbjct: 1628 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687
Query: 1328 VRKEEEKARRELIKQEYLRR--KQQQILEEQGLGKPKSKPKKPRPKSVHREE-------S 1378
VR + E A +EL KQ L QQ++ EQ L + +++ ++ + EE
Sbjct: 1688 VR-QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1746
Query: 1379 CSDSGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVES 1427
+ + K L++ ++ + LAS A E ES + QR+E+
Sbjct: 1747 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1795
Score = 44.3 bits (103), Expect = 0.001
Identities = 137/672 (20%), Positives = 267/672 (39%), Gaps = 61/672 (9%)
Query: 880 QLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPEHFAKEY 939
Q+ + LE +R+ EA+ + A A + +L ++ + + A LR E +
Sbjct: 1566 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSL------QEEHVAVAQLREEAERRAQ 1619
Query: 940 SQHNGEDCGD-AVSKTEDFLVKEEQREELLHEPQDV-DKESLAFAQQHKAKDPVALHELE 997
Q E + A + E + +K + L + ++V ++SLA A+ K K+
Sbjct: 1620 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1679
Query: 998 RNKVISAALLEDTVGEVVDVNECDLSIEKLNETISTLQQAI-----LKISQQQEQLLMKS 1052
R K A+ + + E + L+ + ++ Q+ I + +QQ QLL +
Sbjct: 1680 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1739
Query: 1053 -PTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRLGQGRNSRSGRPAELKVPK 1111
+ + + +++A + V +A +A + + +S + E + +
Sbjct: 1740 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1799
Query: 1112 DRP--QGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSGDPHGKCLFDSY 1169
R + ++R + + L A+ R + L L G+
Sbjct: 1800 FRELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEI 1858
Query: 1170 RLHDES--NQRTLTLSSSK--DANILSEQMSL-KEVLDASVKEVGSSSSDVSGKESVPVE 1224
L ++ N+R L+ + L EQ + K ++ + ++ +S ++ VE
Sbjct: 1859 ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1918
Query: 1225 EPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSE-GDQKPGVGFFFKDEQKAEDEL 1283
+ LR R +E ++ LKA E G A+L E G + + +++AE E
Sbjct: 1919 DTLRQRRQ-VEEEILALKASFEKAAA----GKAELELELGRIRSNAEDTLRSKEQAELEA 1973
Query: 1284 AKKR--AAFLLKQQRKAEE------------ARVRKQQLEAEVELKR--DEARRKAEEDR 1327
A++R AA +++R+AEE AR RK LE LK +EARR E
Sbjct: 1974 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE--- 2030
Query: 1328 VRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSD------ 1381
R E+E AR+ + QE +++ Q EE+ + ++ +++ +E+S D
Sbjct: 2031 -RAEQESARQLQLAQEAAQKRLQ--AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087
Query: 1382 SGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGG--TPSQRVESMEALPILSRNPS 1439
+ ++ +R Q+ + + E E + R ++ A L +
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2147
Query: 1440 RSTDR--DWETASAASSLASVAEYTGPKLFKEPSSKSNKPIIHNAISHCCLAGKVNEPHK 1497
+ R E A+ A+ AE K F E + + K + ++ L + + K
Sbjct: 2148 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTTLRLQLEETDHQK 2206
Query: 1498 NSILEELEKCDA 1509
N + EEL++ A
Sbjct: 2207 NLLDEELQRLKA 2218
Score = 43.1 bits (100), Expect = 0.002
Identities = 46/170 (27%), Positives = 73/170 (42%), Gaps = 27/170 (15%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKR-------DEARRKAEED 1326
K EQ +DE+AK + +QQR+ ++ +Q+L A +E R + RRK EE
Sbjct: 2519 KLEQLFQDEVAKAQQ-LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2577
Query: 1327 RVRKEEEKARRELIKQEYLR-RKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSDSGTK 1385
+ +++ + + EL+ +E R R+Q Q+LEEQ R H EE +
Sbjct: 2578 QQLEQQRRQQEELLAEENQRLREQLQLLEEQ-----------HRAALAHSEEVTASQVAA 2626
Query: 1386 CSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVESMEALPILS 1435
+ P +G AA EPE G + ++ ILS
Sbjct: 2627 TKTLP-------NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2669
Score = 41.6 bits (96), Expect = 0.006
Identities = 120/643 (18%), Positives = 240/643 (37%), Gaps = 86/643 (13%)
Query: 755 EAHPVVFSRYIGEEESAKLQEDMKVKEHEDKDDASGRSSPCLSTASQM-----SSVSMAS 809
EA + + E +L ED + ++ A+ + +Q+ S +
Sbjct: 1855 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1914
Query: 810 GSVKMTSFAERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTWRQKREQSPSQHGKD 869
G V+ T R+++ E + +S +K +E L R + + K+
Sbjct: 1915 GLVEDTLRQRRQVEE----EILALKASFEKAAAGKAE---LELELGRIRSNAEDTLRSKE 1967
Query: 870 PASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPP 929
A L A+ Q + EE+RR EA+++ ++L+A + + A L V++ KA+
Sbjct: 1968 QAELEAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2025
Query: 930 LRPEHFAKEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQDVDKESLAFAQQHKAKD 989
R A++ S + +A K Q EE H AFA Q K +
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQK-------RLQAEEKAH----------AFAVQQKEQ- 2067
Query: 990 PVALHELERNKVISAALLEDTVGEVVDVNECDLSIEKLNETISTLQQAILKISQQQEQLL 1049
EL++ ++L+ GE E+ + ++A Q +E
Sbjct: 2068 -----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR--VQAEREAAQSRRQVEEAER 2120
Query: 1050 MKSPTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRLGQGRNS----RSGRPA 1105
+K S + + +A ++A R Q + + A
Sbjct: 2121 LKQ-----------SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2169
Query: 1106 ELKVPKDRPQGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSGDPHGKC- 1164
E++ K + + R K T L+ + H + D L + + +
Sbjct: 2170 EMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNLLDEELQRLKAEATEAARQRS 2228
Query: 1165 -----LFDSYRLHDESNQRTLTLSSSKDANILSEQMSLKEVLDASVKEVGSSSSDVSGKE 1219
LF +E ++ + + A IL ++ + + L +++ + + + +
Sbjct: 2229 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA-RL 2287
Query: 1220 SVPVEEPLRSRASLIEVDLSDLKAPDED---------GELVSLDGSADLVSEGDQ--KPG 1268
SV +E R R L E DL+ +A E E L A+L+ + + +
Sbjct: 2288 SVAAQEAARLR-QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2346
Query: 1269 VGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVE--------LKRDEAR 1320
+D+++ +LA++ F QR E R R+ ++ AE E + R +AR
Sbjct: 2347 ARRLQEDKEQMAQQLAEETQGF----QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2402
Query: 1321 RKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKS 1363
+ + R RK+ E+ +L + E +++ +++ + + +S
Sbjct: 2403 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2445
Score = 35.4 bits (80), Expect = 0.45
Identities = 118/611 (19%), Positives = 238/611 (38%), Gaps = 89/611 (14%)
Query: 818 AERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTWRQKREQSPSQHGKDPASLLASE 877
AE ++Q+ S + + +K + E A + R+ RE++ + + LA E
Sbjct: 1990 AEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ--LAQE 2045
Query: 878 LVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPE-HFA 936
Q +Q EEK A Q+K+ E +Q L+ ++ + +G+AEAA E A
Sbjct: 2046 AAQKRLQAEEKAHAFAVQQKEQEL---QQTLQQEQSVLDQL--RGEAEAARRAAEEAEEA 2100
Query: 937 KEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQ--------DVDKESLAFAQQHKA- 987
+ ++ V + E E++ + + Q + ++E+ AQ +A
Sbjct: 2101 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2160
Query: 988 --KDPVALHELERNKVISAALLEDTVGEVVDVNECDLSIEK-------LNETI------- 1031
+ A E+E++K + L ++ L +E+ L+E +
Sbjct: 2161 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2220
Query: 1032 -------STLQQAILKISQQQEQLLMKSPTVPVPG------SKNNSQ---DHKVKAPVHF 1075
S +++ + + Q E+L + K+N+Q + +
Sbjct: 2221 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2280
Query: 1076 VEPLSPTGVAGHRKAPRLGQGRNSRSGRPAEL--KVPKDRPQGSSRSKTPTPSVETLPHL 1133
E + VA ++A RL Q + L K+ K++ Q + E L
Sbjct: 2281 AEEAARLSVAA-QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2339
Query: 1134 RPFPASSHPRTPTDPGLDSALEPSGDPHGKCLFDSYRLHDESNQRTLTLSSSKDA-NILS 1192
+ R D A + + + G R + QR L +S+ + +
Sbjct: 2340 KELAQEQARRLQEDKE-QMAQQLAEETQG-----FQRTLEAERQRQLEMSAEAERLKLRV 2393
Query: 1193 EQMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVS 1252
+MS + + ++ G++ E + + +L++ + D D E +
Sbjct: 2394 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2453
Query: 1253 LDGSADLVSEGD--QKPGVGFFFKDEQKA---EDELAKKRAAF----------LLKQQRK 1297
+ A+L E + Q+ K E+ +++L ++ A LL+++R
Sbjct: 2454 -EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2512
Query: 1298 AEEARVRKQQL----EAEVELKRDEARR---KAEEDR---VRKEEEKARRELIKQEYLRR 1347
E+ + + +QL A+ + R+E +R + E++R V EE RR+ +E +RR
Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2572
Query: 1348 KQQQI--LEEQ 1356
KQ+++ LE+Q
Sbjct: 2573 KQEELQQLEQQ 2583
Score = 33.1 bits (74), Expect = 2.2
Identities = 31/131 (23%), Positives = 61/131 (46%), Gaps = 13/131 (9%)
Query: 1205 VKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSEGD 1264
+K + + + +E + ++ R L EV+ A ++ +L A +E +
Sbjct: 1338 IKFISETLRRMEEEERLAEQQRAEERERLAEVEA----ALEKQRQLAEAHAQAKAQAERE 1393
Query: 1265 QKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKA--EEARVRKQQLEAEVELKRDEARRK 1322
K ++ E+ + ++ AA +QQ+++ EE + +Q EAE++ K +A
Sbjct: 1394 AKE------LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA-EA 1446
Query: 1323 AEEDRVRKEEE 1333
AE R+R EEE
Sbjct: 1447 AERSRLRIEEE 1457
Score = 32.3 bits (72), Expect = 3.8
Identities = 24/96 (25%), Positives = 44/96 (45%), Gaps = 7/96 (7%)
Query: 1320 RRKAEEDRVRKEEEKARRE-LIKQEYLRRKQQQILEEQGLGK------PKSKPKKPRPKS 1372
RR EE+R+ +++ RE L + E KQ+Q+ E K K ++ + +
Sbjct: 1346 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1405
Query: 1373 VHREESCSDSGTKCSSTPDNLSRTQSGSSLSLASAA 1408
V REE+ D+ + S + L + + S + + A
Sbjct: 1406 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1441
Score = 32.3 bits (72), Expect = 3.8
Identities = 47/206 (22%), Positives = 82/206 (39%), Gaps = 41/206 (19%)
Query: 1192 SEQMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELV 1251
S Q L+++ +S E+ + + E + R ++++ ++ + +GEL
Sbjct: 1421 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1480
Query: 1252 SLDGSAD-------------------LVSEGDQKPGVGFFFKDEQKAEDELA--KKRAAF 1290
+L A+ + E +K KAE E A K+RA
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1540
Query: 1291 LLKQQR-KAEEARVRKQQLEAE----VELKRDEARRKAEEDRVRK--------------- 1330
L++ R +AEEA R +Q E E V++ + A+R AE + K
Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600
Query: 1331 EEEKARRELIKQEYLRRKQQQILEEQ 1356
+EE +++E RR QQQ E+
Sbjct: 1601 QEEHVAVAQLREEAERRAQQQAEAER 1626
Score = 32.0 bits (71), Expect = 4.9
Identities = 27/86 (31%), Positives = 49/86 (56%), Gaps = 11/86 (12%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAE-EARVRKQQLEAEVELK-RDEARRKAEEDRVRKE 1331
++E+ AE + A++R +R AE EA + KQ+ AE + + +A R+A+E + R +
Sbjct: 1350 EEERLAEQQRAEER-------ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1402
Query: 1332 EEKARRE--LIKQEYLRRKQQQILEE 1355
EE RRE + + +R Q+ L++
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQ 1428
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 48.1 bits (113), Expect = 7e-05
Identities = 47/169 (27%), Positives = 81/169 (47%), Gaps = 16/169 (9%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARR------KAEEDR 1327
++E + E E + +A L+ + +AEE +K +AE E +++EA R KAEE
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 1328 VRKEEEKARRELIKQEYLRR--KQQQILEEQGLGKPKSKPKKPRPKSVHREE-------S 1378
VR + E A +EL KQ L QQ++ EQ L + +++ ++ + EE
Sbjct: 1684 VR-QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 1379 CSDSGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVES 1427
+ + K L++ ++ + LAS A E ES + QR+E+
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Score = 44.3 bits (103), Expect = 0.001
Identities = 137/672 (20%), Positives = 267/672 (39%), Gaps = 61/672 (9%)
Query: 880 QLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPEHFAKEY 939
Q+ + LE +R+ EA+ + A A + +L ++ + + A LR E +
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSL------QEEHVAVAQLREEAERRAQ 1615
Query: 940 SQHNGEDCGD-AVSKTEDFLVKEEQREELLHEPQDV-DKESLAFAQQHKAKDPVALHELE 997
Q E + A + E + +K + L + ++V ++SLA A+ K K+
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1675
Query: 998 RNKVISAALLEDTVGEVVDVNECDLSIEKLNETISTLQQAI-----LKISQQQEQLLMKS 1052
R K A+ + + E + L+ + ++ Q+ I + +QQ QLL +
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735
Query: 1053 -PTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRLGQGRNSRSGRPAELKVPK 1111
+ + + +++A + V +A +A + + +S + E + +
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1795
Query: 1112 DRP--QGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSGDPHGKCLFDSY 1169
R + ++R + + L A+ R + L L G+
Sbjct: 1796 FRELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEI 1854
Query: 1170 RLHDES--NQRTLTLSSSK--DANILSEQMSL-KEVLDASVKEVGSSSSDVSGKESVPVE 1224
L ++ N+R L+ + L EQ + K ++ + ++ +S ++ VE
Sbjct: 1855 ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1914
Query: 1225 EPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSE-GDQKPGVGFFFKDEQKAEDEL 1283
+ LR R +E ++ LKA E G A+L E G + + +++AE E
Sbjct: 1915 DTLRQRRQ-VEEEILALKASFEKAAA----GKAELELELGRIRSNAEDTLRSKEQAELEA 1969
Query: 1284 AKKR--AAFLLKQQRKAEE------------ARVRKQQLEAEVELKR--DEARRKAEEDR 1327
A++R AA +++R+AEE AR RK LE LK +EARR E
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE--- 2026
Query: 1328 VRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSD------ 1381
R E+E AR+ + QE +++ Q EE+ + ++ +++ +E+S D
Sbjct: 2027 -RAEQESARQLQLAQEAAQKRLQ--AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 1382 SGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGG--TPSQRVESMEALPILSRNPS 1439
+ ++ +R Q+ + + E E + R ++ A L +
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2143
Query: 1440 RSTDR--DWETASAASSLASVAEYTGPKLFKEPSSKSNKPIIHNAISHCCLAGKVNEPHK 1497
+ R E A+ A+ AE K F E + + K + ++ L + + K
Sbjct: 2144 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTTLRLQLEETDHQK 2202
Query: 1498 NSILEELEKCDA 1509
N + EEL++ A
Sbjct: 2203 NLLDEELQRLKA 2214
Score = 43.1 bits (100), Expect = 0.002
Identities = 46/170 (27%), Positives = 73/170 (42%), Gaps = 27/170 (15%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKR-------DEARRKAEED 1326
K EQ +DE+AK + +QQR+ ++ +Q+L A +E R + RRK EE
Sbjct: 2515 KLEQLFQDEVAKAQQ-LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2573
Query: 1327 RVRKEEEKARRELIKQEYLR-RKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSDSGTK 1385
+ +++ + + EL+ +E R R+Q Q+LEEQ R H EE +
Sbjct: 2574 QQLEQQRRQQEELLAEENQRLREQLQLLEEQ-----------HRAALAHSEEVTASQVAA 2622
Query: 1386 CSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVESMEALPILS 1435
+ P +G AA EPE G + ++ ILS
Sbjct: 2623 TKTLP-------NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2665
Score = 41.6 bits (96), Expect = 0.006
Identities = 120/643 (18%), Positives = 240/643 (37%), Gaps = 86/643 (13%)
Query: 755 EAHPVVFSRYIGEEESAKLQEDMKVKEHEDKDDASGRSSPCLSTASQM-----SSVSMAS 809
EA + + E +L ED + ++ A+ + +Q+ S +
Sbjct: 1851 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910
Query: 810 GSVKMTSFAERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTWRQKREQSPSQHGKD 869
G V+ T R+++ E + +S +K +E L R + + K+
Sbjct: 1911 GLVEDTLRQRRQVEE----EILALKASFEKAAAGKAE---LELELGRIRSNAEDTLRSKE 1963
Query: 870 PASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPP 929
A L A+ Q + EE+RR EA+++ ++L+A + + A L V++ KA+
Sbjct: 1964 QAELEAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 930 LRPEHFAKEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQDVDKESLAFAQQHKAKD 989
R A++ S + +A K Q EE H AFA Q K +
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQK-------RLQAEEKAH----------AFAVQQKEQ- 2063
Query: 990 PVALHELERNKVISAALLEDTVGEVVDVNECDLSIEKLNETISTLQQAILKISQQQEQLL 1049
EL++ ++L+ GE E+ + ++A Q +E
Sbjct: 2064 -----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR--VQAEREAAQSRRQVEEAER 2116
Query: 1050 MKSPTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRLGQGRNS----RSGRPA 1105
+K S + + +A ++A R Q + + A
Sbjct: 2117 LKQ-----------SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2165
Query: 1106 ELKVPKDRPQGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSGDPHGKC- 1164
E++ K + + R K T L+ + H + D L + + +
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNLLDEELQRLKAEATEAARQRS 2224
Query: 1165 -----LFDSYRLHDESNQRTLTLSSSKDANILSEQMSLKEVLDASVKEVGSSSSDVSGKE 1219
LF +E ++ + + A IL ++ + + L +++ + + + +
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA-RL 2283
Query: 1220 SVPVEEPLRSRASLIEVDLSDLKAPDED---------GELVSLDGSADLVSEGDQ--KPG 1268
SV +E R R L E DL+ +A E E L A+L+ + + +
Sbjct: 2284 SVAAQEAARLR-QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2342
Query: 1269 VGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVE--------LKRDEAR 1320
+D+++ +LA++ F QR E R R+ ++ AE E + R +AR
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGF----QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398
Query: 1321 RKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKS 1363
+ + R RK+ E+ +L + E +++ +++ + + +S
Sbjct: 2399 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441
Score = 35.4 bits (80), Expect = 0.45
Identities = 118/611 (19%), Positives = 238/611 (38%), Gaps = 89/611 (14%)
Query: 818 AERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTWRQKREQSPSQHGKDPASLLASE 877
AE ++Q+ S + + +K + E A + R+ RE++ + + LA E
Sbjct: 1986 AEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ--LAQE 2041
Query: 878 LVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPE-HFA 936
Q +Q EEK A Q+K+ E +Q L+ ++ + +G+AEAA E A
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQEL---QQTLQQEQSVLDQL--RGEAEAARRAAEEAEEA 2096
Query: 937 KEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQ--------DVDKESLAFAQQHKA- 987
+ ++ V + E E++ + + Q + ++E+ AQ +A
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2156
Query: 988 --KDPVALHELERNKVISAALLEDTVGEVVDVNECDLSIEK-------LNETI------- 1031
+ A E+E++K + L ++ L +E+ L+E +
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 1032 -------STLQQAILKISQQQEQLLMKSPTVPVPG------SKNNSQ---DHKVKAPVHF 1075
S +++ + + Q E+L + K+N+Q + +
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276
Query: 1076 VEPLSPTGVAGHRKAPRLGQGRNSRSGRPAEL--KVPKDRPQGSSRSKTPTPSVETLPHL 1133
E + VA ++A RL Q + L K+ K++ Q + E L
Sbjct: 2277 AEEAARLSVAA-QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335
Query: 1134 RPFPASSHPRTPTDPGLDSALEPSGDPHGKCLFDSYRLHDESNQRTLTLSSSKDA-NILS 1192
+ R D A + + + G R + QR L +S+ + +
Sbjct: 2336 KELAQEQARRLQEDKE-QMAQQLAEETQG-----FQRTLEAERQRQLEMSAEAERLKLRV 2389
Query: 1193 EQMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVS 1252
+MS + + ++ G++ E + + +L++ + D D E +
Sbjct: 2390 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2449
Query: 1253 LDGSADLVSEGD--QKPGVGFFFKDEQKA---EDELAKKRAAF----------LLKQQRK 1297
+ A+L E + Q+ K E+ +++L ++ A LL+++R
Sbjct: 2450 -EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508
Query: 1298 AEEARVRKQQL----EAEVELKRDEARR---KAEEDR---VRKEEEKARRELIKQEYLRR 1347
E+ + + +QL A+ + R+E +R + E++R V EE RR+ +E +RR
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 1348 KQQQI--LEEQ 1356
KQ+++ LE+Q
Sbjct: 2569 KQEELQQLEQQ 2579
Score = 33.1 bits (74), Expect = 2.2
Identities = 31/131 (23%), Positives = 61/131 (46%), Gaps = 13/131 (9%)
Query: 1205 VKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSEGD 1264
+K + + + +E + ++ R L EV+ A ++ +L A +E +
Sbjct: 1334 IKFISETLRRMEEEERLAEQQRAEERERLAEVEA----ALEKQRQLAEAHAQAKAQAERE 1389
Query: 1265 QKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKA--EEARVRKQQLEAEVELKRDEARRK 1322
K ++ E+ + ++ AA +QQ+++ EE + +Q EAE++ K +A
Sbjct: 1390 AKE------LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA-EA 1442
Query: 1323 AEEDRVRKEEE 1333
AE R+R EEE
Sbjct: 1443 AERSRLRIEEE 1453
Score = 32.3 bits (72), Expect = 3.8
Identities = 24/96 (25%), Positives = 44/96 (45%), Gaps = 7/96 (7%)
Query: 1320 RRKAEEDRVRKEEEKARRE-LIKQEYLRRKQQQILEEQGLGK------PKSKPKKPRPKS 1372
RR EE+R+ +++ RE L + E KQ+Q+ E K K ++ + +
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 1373 VHREESCSDSGTKCSSTPDNLSRTQSGSSLSLASAA 1408
V REE+ D+ + S + L + + S + + A
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1437
Score = 32.3 bits (72), Expect = 3.8
Identities = 47/206 (22%), Positives = 82/206 (39%), Gaps = 41/206 (19%)
Query: 1192 SEQMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELV 1251
S Q L+++ +S E+ + + E + R ++++ ++ + +GEL
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476
Query: 1252 SLDGSAD-------------------LVSEGDQKPGVGFFFKDEQKAEDELA--KKRAAF 1290
+L A+ + E +K KAE E A K+RA
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 1291 LLKQQR-KAEEARVRKQQLEAE----VELKRDEARRKAEEDRVRK--------------- 1330
L++ R +AEEA R +Q E E V++ + A+R AE + K
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 1331 EEEKARRELIKQEYLRRKQQQILEEQ 1356
+EE +++E RR QQQ E+
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAER 1622
Score = 32.0 bits (71), Expect = 4.9
Identities = 27/86 (31%), Positives = 49/86 (56%), Gaps = 11/86 (12%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAE-EARVRKQQLEAEVELK-RDEARRKAEEDRVRKE 1331
++E+ AE + A++R +R AE EA + KQ+ AE + + +A R+A+E + R +
Sbjct: 1346 EEERLAEQQRAEER-------ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 1332 EEKARRE--LIKQEYLRRKQQQILEE 1355
EE RRE + + +R Q+ L++
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQ 1424
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 48.1 bits (113), Expect = 7e-05
Identities = 47/169 (27%), Positives = 81/169 (47%), Gaps = 16/169 (9%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARR------KAEEDR 1327
++E + E E + +A L+ + +AEE +K +AE E +++EA R KAEE
Sbjct: 1592 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1651
Query: 1328 VRKEEEKARRELIKQEYLRR--KQQQILEEQGLGKPKSKPKKPRPKSVHREE-------S 1378
VR + E A +EL KQ L QQ++ EQ L + +++ ++ + EE
Sbjct: 1652 VR-QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1710
Query: 1379 CSDSGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVES 1427
+ + K L++ ++ + LAS A E ES + QR+E+
Sbjct: 1711 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1759
Score = 44.3 bits (103), Expect = 0.001
Identities = 137/672 (20%), Positives = 267/672 (39%), Gaps = 61/672 (9%)
Query: 880 QLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPEHFAKEY 939
Q+ + LE +R+ EA+ + A A + +L ++ + + A LR E +
Sbjct: 1530 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSL------QEEHVAVAQLREEAERRAQ 1583
Query: 940 SQHNGEDCGD-AVSKTEDFLVKEEQREELLHEPQDV-DKESLAFAQQHKAKDPVALHELE 997
Q E + A + E + +K + L + ++V ++SLA A+ K K+
Sbjct: 1584 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1643
Query: 998 RNKVISAALLEDTVGEVVDVNECDLSIEKLNETISTLQQAI-----LKISQQQEQLLMKS 1052
R K A+ + + E + L+ + ++ Q+ I + +QQ QLL +
Sbjct: 1644 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1703
Query: 1053 -PTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRLGQGRNSRSGRPAELKVPK 1111
+ + + +++A + V +A +A + + +S + E + +
Sbjct: 1704 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1763
Query: 1112 DRP--QGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSGDPHGKCLFDSY 1169
R + ++R + + L A+ R + L L G+
Sbjct: 1764 FRELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEI 1822
Query: 1170 RLHDES--NQRTLTLSSSK--DANILSEQMSL-KEVLDASVKEVGSSSSDVSGKESVPVE 1224
L ++ N+R L+ + L EQ + K ++ + ++ +S ++ VE
Sbjct: 1823 ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1882
Query: 1225 EPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSE-GDQKPGVGFFFKDEQKAEDEL 1283
+ LR R +E ++ LKA E G A+L E G + + +++AE E
Sbjct: 1883 DTLRQRRQ-VEEEILALKASFEKAAA----GKAELELELGRIRSNAEDTLRSKEQAELEA 1937
Query: 1284 AKKR--AAFLLKQQRKAEE------------ARVRKQQLEAEVELKR--DEARRKAEEDR 1327
A++R AA +++R+AEE AR RK LE LK +EARR E
Sbjct: 1938 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE--- 1994
Query: 1328 VRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSD------ 1381
R E+E AR+ + QE +++ Q EE+ + ++ +++ +E+S D
Sbjct: 1995 -RAEQESARQLQLAQEAAQKRLQ--AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2051
Query: 1382 SGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGG--TPSQRVESMEALPILSRNPS 1439
+ ++ +R Q+ + + E E + R ++ A L +
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2111
Query: 1440 RSTDR--DWETASAASSLASVAEYTGPKLFKEPSSKSNKPIIHNAISHCCLAGKVNEPHK 1497
+ R E A+ A+ AE K F E + + K + ++ L + + K
Sbjct: 2112 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTTLRLQLEETDHQK 2170
Query: 1498 NSILEELEKCDA 1509
N + EEL++ A
Sbjct: 2171 NLLDEELQRLKA 2182
Score = 43.1 bits (100), Expect = 0.002
Identities = 46/170 (27%), Positives = 73/170 (42%), Gaps = 27/170 (15%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKR-------DEARRKAEED 1326
K EQ +DE+AK + +QQR+ ++ +Q+L A +E R + RRK EE
Sbjct: 2483 KLEQLFQDEVAKAQQ-LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2541
Query: 1327 RVRKEEEKARRELIKQEYLR-RKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSDSGTK 1385
+ +++ + + EL+ +E R R+Q Q+LEEQ R H EE +
Sbjct: 2542 QQLEQQRRQQEELLAEENQRLREQLQLLEEQ-----------HRAALAHSEEVTASQVAA 2590
Query: 1386 CSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVESMEALPILS 1435
+ P +G AA EPE G + ++ ILS
Sbjct: 2591 TKTLP-------NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2633
Score = 41.6 bits (96), Expect = 0.006
Identities = 120/643 (18%), Positives = 240/643 (37%), Gaps = 86/643 (13%)
Query: 755 EAHPVVFSRYIGEEESAKLQEDMKVKEHEDKDDASGRSSPCLSTASQM-----SSVSMAS 809
EA + + E +L ED + ++ A+ + +Q+ S +
Sbjct: 1819 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1878
Query: 810 GSVKMTSFAERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTWRQKREQSPSQHGKD 869
G V+ T R+++ E + +S +K +E L R + + K+
Sbjct: 1879 GLVEDTLRQRRQVEE----EILALKASFEKAAAGKAE---LELELGRIRSNAEDTLRSKE 1931
Query: 870 PASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPP 929
A L A+ Q + EE+RR EA+++ ++L+A + + A L V++ KA+
Sbjct: 1932 QAELEAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1989
Query: 930 LRPEHFAKEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQDVDKESLAFAQQHKAKD 989
R A++ S + +A K Q EE H AFA Q K +
Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQK-------RLQAEEKAH----------AFAVQQKEQ- 2031
Query: 990 PVALHELERNKVISAALLEDTVGEVVDVNECDLSIEKLNETISTLQQAILKISQQQEQLL 1049
EL++ ++L+ GE E+ + ++A Q +E
Sbjct: 2032 -----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR--VQAEREAAQSRRQVEEAER 2084
Query: 1050 MKSPTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRLGQGRNS----RSGRPA 1105
+K S + + +A ++A R Q + + A
Sbjct: 2085 LKQ-----------SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2133
Query: 1106 ELKVPKDRPQGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSGDPHGKC- 1164
E++ K + + R K T L+ + H + D L + + +
Sbjct: 2134 EMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNLLDEELQRLKAEATEAARQRS 2192
Query: 1165 -----LFDSYRLHDESNQRTLTLSSSKDANILSEQMSLKEVLDASVKEVGSSSSDVSGKE 1219
LF +E ++ + + A IL ++ + + L +++ + + + +
Sbjct: 2193 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA-RL 2251
Query: 1220 SVPVEEPLRSRASLIEVDLSDLKAPDED---------GELVSLDGSADLVSEGDQ--KPG 1268
SV +E R R L E DL+ +A E E L A+L+ + + +
Sbjct: 2252 SVAAQEAARLR-QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2310
Query: 1269 VGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVE--------LKRDEAR 1320
+D+++ +LA++ F QR E R R+ ++ AE E + R +AR
Sbjct: 2311 ARRLQEDKEQMAQQLAEETQGF----QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2366
Query: 1321 RKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKS 1363
+ + R RK+ E+ +L + E +++ +++ + + +S
Sbjct: 2367 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2409
Score = 35.4 bits (80), Expect = 0.45
Identities = 118/611 (19%), Positives = 238/611 (38%), Gaps = 89/611 (14%)
Query: 818 AERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTWRQKREQSPSQHGKDPASLLASE 877
AE ++Q+ S + + +K + E A + R+ RE++ + + LA E
Sbjct: 1954 AEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ--LAQE 2009
Query: 878 LVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPE-HFA 936
Q +Q EEK A Q+K+ E +Q L+ ++ + +G+AEAA E A
Sbjct: 2010 AAQKRLQAEEKAHAFAVQQKEQEL---QQTLQQEQSVLDQL--RGEAEAARRAAEEAEEA 2064
Query: 937 KEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQ--------DVDKESLAFAQQHKA- 987
+ ++ V + E E++ + + Q + ++E+ AQ +A
Sbjct: 2065 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2124
Query: 988 --KDPVALHELERNKVISAALLEDTVGEVVDVNECDLSIEK-------LNETI------- 1031
+ A E+E++K + L ++ L +E+ L+E +
Sbjct: 2125 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2184
Query: 1032 -------STLQQAILKISQQQEQLLMKSPTVPVPG------SKNNSQ---DHKVKAPVHF 1075
S +++ + + Q E+L + K+N+Q + +
Sbjct: 2185 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2244
Query: 1076 VEPLSPTGVAGHRKAPRLGQGRNSRSGRPAEL--KVPKDRPQGSSRSKTPTPSVETLPHL 1133
E + VA ++A RL Q + L K+ K++ Q + E L
Sbjct: 2245 AEEAARLSVAA-QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2303
Query: 1134 RPFPASSHPRTPTDPGLDSALEPSGDPHGKCLFDSYRLHDESNQRTLTLSSSKDA-NILS 1192
+ R D A + + + G R + QR L +S+ + +
Sbjct: 2304 KELAQEQARRLQEDKE-QMAQQLAEETQG-----FQRTLEAERQRQLEMSAEAERLKLRV 2357
Query: 1193 EQMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVS 1252
+MS + + ++ G++ E + + +L++ + D D E +
Sbjct: 2358 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2417
Query: 1253 LDGSADLVSEGD--QKPGVGFFFKDEQKA---EDELAKKRAAF----------LLKQQRK 1297
+ A+L E + Q+ K E+ +++L ++ A LL+++R
Sbjct: 2418 -EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2476
Query: 1298 AEEARVRKQQL----EAEVELKRDEARR---KAEEDR---VRKEEEKARRELIKQEYLRR 1347
E+ + + +QL A+ + R+E +R + E++R V EE RR+ +E +RR
Sbjct: 2477 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2536
Query: 1348 KQQQI--LEEQ 1356
KQ+++ LE+Q
Sbjct: 2537 KQEELQQLEQQ 2547
Score = 33.1 bits (74), Expect = 2.2
Identities = 31/131 (23%), Positives = 61/131 (46%), Gaps = 13/131 (9%)
Query: 1205 VKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSEGD 1264
+K + + + +E + ++ R L EV+ A ++ +L A +E +
Sbjct: 1302 IKFISETLRRMEEEERLAEQQRAEERERLAEVEA----ALEKQRQLAEAHAQAKAQAERE 1357
Query: 1265 QKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKA--EEARVRKQQLEAEVELKRDEARRK 1322
K ++ E+ + ++ AA +QQ+++ EE + +Q EAE++ K +A
Sbjct: 1358 AKE------LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA-EA 1410
Query: 1323 AEEDRVRKEEE 1333
AE R+R EEE
Sbjct: 1411 AERSRLRIEEE 1421
Score = 32.3 bits (72), Expect = 3.8
Identities = 24/96 (25%), Positives = 44/96 (45%), Gaps = 7/96 (7%)
Query: 1320 RRKAEEDRVRKEEEKARRE-LIKQEYLRRKQQQILEEQGLGK------PKSKPKKPRPKS 1372
RR EE+R+ +++ RE L + E KQ+Q+ E K K ++ + +
Sbjct: 1310 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1369
Query: 1373 VHREESCSDSGTKCSSTPDNLSRTQSGSSLSLASAA 1408
V REE+ D+ + S + L + + S + + A
Sbjct: 1370 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1405
Score = 32.3 bits (72), Expect = 3.8
Identities = 47/206 (22%), Positives = 82/206 (39%), Gaps = 41/206 (19%)
Query: 1192 SEQMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELV 1251
S Q L+++ +S E+ + + E + R ++++ ++ + +GEL
Sbjct: 1385 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1444
Query: 1252 SLDGSAD-------------------LVSEGDQKPGVGFFFKDEQKAEDELA--KKRAAF 1290
+L A+ + E +K KAE E A K+RA
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1504
Query: 1291 LLKQQR-KAEEARVRKQQLEAE----VELKRDEARRKAEEDRVRK--------------- 1330
L++ R +AEEA R +Q E E V++ + A+R AE + K
Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564
Query: 1331 EEEKARRELIKQEYLRRKQQQILEEQ 1356
+EE +++E RR QQQ E+
Sbjct: 1565 QEEHVAVAQLREEAERRAQQQAEAER 1590
Score = 32.0 bits (71), Expect = 4.9
Identities = 27/86 (31%), Positives = 49/86 (56%), Gaps = 11/86 (12%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAE-EARVRKQQLEAEVELK-RDEARRKAEEDRVRKE 1331
++E+ AE + A++R +R AE EA + KQ+ AE + + +A R+A+E + R +
Sbjct: 1314 EEERLAEQQRAEER-------ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1366
Query: 1332 EEKARRE--LIKQEYLRRKQQQILEE 1355
EE RRE + + +R Q+ L++
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQ 1392
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 48.1 bits (113), Expect = 7e-05
Identities = 47/169 (27%), Positives = 81/169 (47%), Gaps = 16/169 (9%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARR------KAEEDR 1327
++E + E E + +A L+ + +AEE +K +AE E +++EA R KAEE
Sbjct: 1761 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1820
Query: 1328 VRKEEEKARRELIKQEYLRR--KQQQILEEQGLGKPKSKPKKPRPKSVHREE-------S 1378
VR + E A +EL KQ L QQ++ EQ L + +++ ++ + EE
Sbjct: 1821 VR-QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1879
Query: 1379 CSDSGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVES 1427
+ + K L++ ++ + LAS A E ES + QR+E+
Sbjct: 1880 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928
Score = 44.3 bits (103), Expect = 0.001
Identities = 137/672 (20%), Positives = 267/672 (39%), Gaps = 61/672 (9%)
Query: 880 QLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPEHFAKEY 939
Q+ + LE +R+ EA+ + A A + +L ++ + + A LR E +
Sbjct: 1699 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSL------QEEHVAVAQLREEAERRAQ 1752
Query: 940 SQHNGEDCGD-AVSKTEDFLVKEEQREELLHEPQDV-DKESLAFAQQHKAKDPVALHELE 997
Q E + A + E + +K + L + ++V ++SLA A+ K K+
Sbjct: 1753 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1812
Query: 998 RNKVISAALLEDTVGEVVDVNECDLSIEKLNETISTLQQAI-----LKISQQQEQLLMKS 1052
R K A+ + + E + L+ + ++ Q+ I + +QQ QLL +
Sbjct: 1813 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1872
Query: 1053 -PTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRLGQGRNSRSGRPAELKVPK 1111
+ + + +++A + V +A +A + + +S + E + +
Sbjct: 1873 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1932
Query: 1112 DRP--QGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSGDPHGKCLFDSY 1169
R + ++R + + L A+ R + L L G+
Sbjct: 1933 FRELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEI 1991
Query: 1170 RLHDES--NQRTLTLSSSK--DANILSEQMSL-KEVLDASVKEVGSSSSDVSGKESVPVE 1224
L ++ N+R L+ + L EQ + K ++ + ++ +S ++ VE
Sbjct: 1992 ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 2051
Query: 1225 EPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSE-GDQKPGVGFFFKDEQKAEDEL 1283
+ LR R +E ++ LKA E G A+L E G + + +++AE E
Sbjct: 2052 DTLRQRRQ-VEEEILALKASFEKAAA----GKAELELELGRIRSNAEDTLRSKEQAELEA 2106
Query: 1284 AKKR--AAFLLKQQRKAEE------------ARVRKQQLEAEVELKR--DEARRKAEEDR 1327
A++R AA +++R+AEE AR RK LE LK +EARR E
Sbjct: 2107 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE--- 2163
Query: 1328 VRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSD------ 1381
R E+E AR+ + QE +++ Q EE+ + ++ +++ +E+S D
Sbjct: 2164 -RAEQESARQLQLAQEAAQKRLQ--AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220
Query: 1382 SGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGG--TPSQRVESMEALPILSRNPS 1439
+ ++ +R Q+ + + E E + R ++ A L +
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2280
Query: 1440 RSTDR--DWETASAASSLASVAEYTGPKLFKEPSSKSNKPIIHNAISHCCLAGKVNEPHK 1497
+ R E A+ A+ AE K F E + + K + ++ L + + K
Sbjct: 2281 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTTLRLQLEETDHQK 2339
Query: 1498 NSILEELEKCDA 1509
N + EEL++ A
Sbjct: 2340 NLLDEELQRLKA 2351
Score = 43.1 bits (100), Expect = 0.002
Identities = 46/170 (27%), Positives = 73/170 (42%), Gaps = 27/170 (15%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKR-------DEARRKAEED 1326
K EQ +DE+AK + +QQR+ ++ +Q+L A +E R + RRK EE
Sbjct: 2652 KLEQLFQDEVAKAQQ-LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2710
Query: 1327 RVRKEEEKARRELIKQEYLR-RKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSDSGTK 1385
+ +++ + + EL+ +E R R+Q Q+LEEQ R H EE +
Sbjct: 2711 QQLEQQRRQQEELLAEENQRLREQLQLLEEQ-----------HRAALAHSEEVTASQVAA 2759
Query: 1386 CSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVESMEALPILS 1435
+ P +G AA EPE G + ++ ILS
Sbjct: 2760 TKTLP-------NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2802
Score = 41.6 bits (96), Expect = 0.006
Identities = 120/643 (18%), Positives = 240/643 (37%), Gaps = 86/643 (13%)
Query: 755 EAHPVVFSRYIGEEESAKLQEDMKVKEHEDKDDASGRSSPCLSTASQM-----SSVSMAS 809
EA + + E +L ED + ++ A+ + +Q+ S +
Sbjct: 1988 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 2047
Query: 810 GSVKMTSFAERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTWRQKREQSPSQHGKD 869
G V+ T R+++ E + +S +K +E L R + + K+
Sbjct: 2048 GLVEDTLRQRRQVEE----EILALKASFEKAAAGKAE---LELELGRIRSNAEDTLRSKE 2100
Query: 870 PASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPP 929
A L A+ Q + EE+RR EA+++ ++L+A + + A L V++ KA+
Sbjct: 2101 QAELEAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158
Query: 930 LRPEHFAKEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQDVDKESLAFAQQHKAKD 989
R A++ S + +A K Q EE H AFA Q K +
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQK-------RLQAEEKAH----------AFAVQQKEQ- 2200
Query: 990 PVALHELERNKVISAALLEDTVGEVVDVNECDLSIEKLNETISTLQQAILKISQQQEQLL 1049
EL++ ++L+ GE E+ + ++A Q +E
Sbjct: 2201 -----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR--VQAEREAAQSRRQVEEAER 2253
Query: 1050 MKSPTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRLGQGRNS----RSGRPA 1105
+K S + + +A ++A R Q + + A
Sbjct: 2254 LKQ-----------SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2302
Query: 1106 ELKVPKDRPQGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSGDPHGKC- 1164
E++ K + + R K T L+ + H + D L + + +
Sbjct: 2303 EMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNLLDEELQRLKAEATEAARQRS 2361
Query: 1165 -----LFDSYRLHDESNQRTLTLSSSKDANILSEQMSLKEVLDASVKEVGSSSSDVSGKE 1219
LF +E ++ + + A IL ++ + + L +++ + + + +
Sbjct: 2362 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA-RL 2420
Query: 1220 SVPVEEPLRSRASLIEVDLSDLKAPDED---------GELVSLDGSADLVSEGDQ--KPG 1268
SV +E R R L E DL+ +A E E L A+L+ + + +
Sbjct: 2421 SVAAQEAARLR-QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2479
Query: 1269 VGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVE--------LKRDEAR 1320
+D+++ +LA++ F QR E R R+ ++ AE E + R +AR
Sbjct: 2480 ARRLQEDKEQMAQQLAEETQGF----QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2535
Query: 1321 RKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKS 1363
+ + R RK+ E+ +L + E +++ +++ + + +S
Sbjct: 2536 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2578
Score = 35.4 bits (80), Expect = 0.45
Identities = 118/611 (19%), Positives = 238/611 (38%), Gaps = 89/611 (14%)
Query: 818 AERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTWRQKREQSPSQHGKDPASLLASE 877
AE ++Q+ S + + +K + E A + R+ RE++ + + LA E
Sbjct: 2123 AEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ--LAQE 2178
Query: 878 LVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPE-HFA 936
Q +Q EEK A Q+K+ E +Q L+ ++ + +G+AEAA E A
Sbjct: 2179 AAQKRLQAEEKAHAFAVQQKEQEL---QQTLQQEQSVLDQL--RGEAEAARRAAEEAEEA 2233
Query: 937 KEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQ--------DVDKESLAFAQQHKA- 987
+ ++ V + E E++ + + Q + ++E+ AQ +A
Sbjct: 2234 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2293
Query: 988 --KDPVALHELERNKVISAALLEDTVGEVVDVNECDLSIEK-------LNETI------- 1031
+ A E+E++K + L ++ L +E+ L+E +
Sbjct: 2294 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2353
Query: 1032 -------STLQQAILKISQQQEQLLMKSPTVPVPG------SKNNSQ---DHKVKAPVHF 1075
S +++ + + Q E+L + K+N+Q + +
Sbjct: 2354 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2413
Query: 1076 VEPLSPTGVAGHRKAPRLGQGRNSRSGRPAEL--KVPKDRPQGSSRSKTPTPSVETLPHL 1133
E + VA ++A RL Q + L K+ K++ Q + E L
Sbjct: 2414 AEEAARLSVAA-QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2472
Query: 1134 RPFPASSHPRTPTDPGLDSALEPSGDPHGKCLFDSYRLHDESNQRTLTLSSSKDA-NILS 1192
+ R D A + + + G R + QR L +S+ + +
Sbjct: 2473 KELAQEQARRLQEDKE-QMAQQLAEETQG-----FQRTLEAERQRQLEMSAEAERLKLRV 2526
Query: 1193 EQMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVS 1252
+MS + + ++ G++ E + + +L++ + D D E +
Sbjct: 2527 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2586
Query: 1253 LDGSADLVSEGD--QKPGVGFFFKDEQKA---EDELAKKRAAF----------LLKQQRK 1297
+ A+L E + Q+ K E+ +++L ++ A LL+++R
Sbjct: 2587 -EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2645
Query: 1298 AEEARVRKQQL----EAEVELKRDEARR---KAEEDR---VRKEEEKARRELIKQEYLRR 1347
E+ + + +QL A+ + R+E +R + E++R V EE RR+ +E +RR
Sbjct: 2646 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2705
Query: 1348 KQQQI--LEEQ 1356
KQ+++ LE+Q
Sbjct: 2706 KQEELQQLEQQ 2716
Score = 33.1 bits (74), Expect = 2.2
Identities = 31/131 (23%), Positives = 61/131 (46%), Gaps = 13/131 (9%)
Query: 1205 VKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSEGD 1264
+K + + + +E + ++ R L EV+ A ++ +L A +E +
Sbjct: 1471 IKFISETLRRMEEEERLAEQQRAEERERLAEVEA----ALEKQRQLAEAHAQAKAQAERE 1526
Query: 1265 QKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKA--EEARVRKQQLEAEVELKRDEARRK 1322
K ++ E+ + ++ AA +QQ+++ EE + +Q EAE++ K +A
Sbjct: 1527 AKE------LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA-EA 1579
Query: 1323 AEEDRVRKEEE 1333
AE R+R EEE
Sbjct: 1580 AERSRLRIEEE 1590
Score = 32.3 bits (72), Expect = 3.8
Identities = 24/96 (25%), Positives = 44/96 (45%), Gaps = 7/96 (7%)
Query: 1320 RRKAEEDRVRKEEEKARRE-LIKQEYLRRKQQQILEEQGLGK------PKSKPKKPRPKS 1372
RR EE+R+ +++ RE L + E KQ+Q+ E K K ++ + +
Sbjct: 1479 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1538
Query: 1373 VHREESCSDSGTKCSSTPDNLSRTQSGSSLSLASAA 1408
V REE+ D+ + S + L + + S + + A
Sbjct: 1539 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1574
Score = 32.3 bits (72), Expect = 3.8
Identities = 47/206 (22%), Positives = 82/206 (39%), Gaps = 41/206 (19%)
Query: 1192 SEQMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELV 1251
S Q L+++ +S E+ + + E + R ++++ ++ + +GEL
Sbjct: 1554 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1613
Query: 1252 SLDGSAD-------------------LVSEGDQKPGVGFFFKDEQKAEDELA--KKRAAF 1290
+L A+ + E +K KAE E A K+RA
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1673
Query: 1291 LLKQQR-KAEEARVRKQQLEAE----VELKRDEARRKAEEDRVRK--------------- 1330
L++ R +AEEA R +Q E E V++ + A+R AE + K
Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733
Query: 1331 EEEKARRELIKQEYLRRKQQQILEEQ 1356
+EE +++E RR QQQ E+
Sbjct: 1734 QEEHVAVAQLREEAERRAQQQAEAER 1759
Score = 32.0 bits (71), Expect = 4.9
Identities = 27/86 (31%), Positives = 49/86 (56%), Gaps = 11/86 (12%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAE-EARVRKQQLEAEVELK-RDEARRKAEEDRVRKE 1331
++E+ AE + A++R +R AE EA + KQ+ AE + + +A R+A+E + R +
Sbjct: 1483 EEERLAEQQRAEER-------ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1535
Query: 1332 EEKARRE--LIKQEYLRRKQQQILEE 1355
EE RRE + + +R Q+ L++
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQ 1561
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 48.1 bits (113), Expect = 7e-05
Identities = 47/169 (27%), Positives = 81/169 (47%), Gaps = 16/169 (9%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARR------KAEEDR 1327
++E + E E + +A L+ + +AEE +K +AE E +++EA R KAEE
Sbjct: 1602 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1661
Query: 1328 VRKEEEKARRELIKQEYLRR--KQQQILEEQGLGKPKSKPKKPRPKSVHREE-------S 1378
VR + E A +EL KQ L QQ++ EQ L + +++ ++ + EE
Sbjct: 1662 VR-QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1720
Query: 1379 CSDSGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVES 1427
+ + K L++ ++ + LAS A E ES + QR+E+
Sbjct: 1721 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769
Score = 44.3 bits (103), Expect = 0.001
Identities = 137/672 (20%), Positives = 267/672 (39%), Gaps = 61/672 (9%)
Query: 880 QLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPEHFAKEY 939
Q+ + LE +R+ EA+ + A A + +L ++ + + A LR E +
Sbjct: 1540 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSL------QEEHVAVAQLREEAERRAQ 1593
Query: 940 SQHNGEDCGD-AVSKTEDFLVKEEQREELLHEPQDV-DKESLAFAQQHKAKDPVALHELE 997
Q E + A + E + +K + L + ++V ++SLA A+ K K+
Sbjct: 1594 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1653
Query: 998 RNKVISAALLEDTVGEVVDVNECDLSIEKLNETISTLQQAI-----LKISQQQEQLLMKS 1052
R K A+ + + E + L+ + ++ Q+ I + +QQ QLL +
Sbjct: 1654 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1713
Query: 1053 -PTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRLGQGRNSRSGRPAELKVPK 1111
+ + + +++A + V +A +A + + +S + E + +
Sbjct: 1714 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1773
Query: 1112 DRP--QGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSGDPHGKCLFDSY 1169
R + ++R + + L A+ R + L L G+
Sbjct: 1774 FRELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEI 1832
Query: 1170 RLHDES--NQRTLTLSSSK--DANILSEQMSL-KEVLDASVKEVGSSSSDVSGKESVPVE 1224
L ++ N+R L+ + L EQ + K ++ + ++ +S ++ VE
Sbjct: 1833 ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1892
Query: 1225 EPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSE-GDQKPGVGFFFKDEQKAEDEL 1283
+ LR R +E ++ LKA E G A+L E G + + +++AE E
Sbjct: 1893 DTLRQRRQ-VEEEILALKASFEKAAA----GKAELELELGRIRSNAEDTLRSKEQAELEA 1947
Query: 1284 AKKR--AAFLLKQQRKAEE------------ARVRKQQLEAEVELKR--DEARRKAEEDR 1327
A++R AA +++R+AEE AR RK LE LK +EARR E
Sbjct: 1948 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE--- 2004
Query: 1328 VRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSD------ 1381
R E+E AR+ + QE +++ Q EE+ + ++ +++ +E+S D
Sbjct: 2005 -RAEQESARQLQLAQEAAQKRLQ--AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2061
Query: 1382 SGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGG--TPSQRVESMEALPILSRNPS 1439
+ ++ +R Q+ + + E E + R ++ A L +
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2121
Query: 1440 RSTDR--DWETASAASSLASVAEYTGPKLFKEPSSKSNKPIIHNAISHCCLAGKVNEPHK 1497
+ R E A+ A+ AE K F E + + K + ++ L + + K
Sbjct: 2122 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTTLRLQLEETDHQK 2180
Query: 1498 NSILEELEKCDA 1509
N + EEL++ A
Sbjct: 2181 NLLDEELQRLKA 2192
Score = 43.1 bits (100), Expect = 0.002
Identities = 46/170 (27%), Positives = 73/170 (42%), Gaps = 27/170 (15%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKR-------DEARRKAEED 1326
K EQ +DE+AK + +QQR+ ++ +Q+L A +E R + RRK EE
Sbjct: 2493 KLEQLFQDEVAKAQQ-LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2551
Query: 1327 RVRKEEEKARRELIKQEYLR-RKQQQILEEQGLGKPKSKPKKPRPKSVHREESCSDSGTK 1385
+ +++ + + EL+ +E R R+Q Q+LEEQ R H EE +
Sbjct: 2552 QQLEQQRRQQEELLAEENQRLREQLQLLEEQ-----------HRAALAHSEEVTASQVAA 2600
Query: 1386 CSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVESMEALPILS 1435
+ P +G AA EPE G + ++ ILS
Sbjct: 2601 TKTLP-------NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2643
Score = 41.6 bits (96), Expect = 0.006
Identities = 120/643 (18%), Positives = 240/643 (37%), Gaps = 86/643 (13%)
Query: 755 EAHPVVFSRYIGEEESAKLQEDMKVKEHEDKDDASGRSSPCLSTASQM-----SSVSMAS 809
EA + + E +L ED + ++ A+ + +Q+ S +
Sbjct: 1829 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1888
Query: 810 GSVKMTSFAERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTWRQKREQSPSQHGKD 869
G V+ T R+++ E + +S +K +E L R + + K+
Sbjct: 1889 GLVEDTLRQRRQVEE----EILALKASFEKAAAGKAE---LELELGRIRSNAEDTLRSKE 1941
Query: 870 PASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPP 929
A L A+ Q + EE+RR EA+++ ++L+A + + A L V++ KA+
Sbjct: 1942 QAELEAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1999
Query: 930 LRPEHFAKEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQDVDKESLAFAQQHKAKD 989
R A++ S + +A K Q EE H AFA Q K +
Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQK-------RLQAEEKAH----------AFAVQQKEQ- 2041
Query: 990 PVALHELERNKVISAALLEDTVGEVVDVNECDLSIEKLNETISTLQQAILKISQQQEQLL 1049
EL++ ++L+ GE E+ + ++A Q +E
Sbjct: 2042 -----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR--VQAEREAAQSRRQVEEAER 2094
Query: 1050 MKSPTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRLGQGRNS----RSGRPA 1105
+K S + + +A ++A R Q + + A
Sbjct: 2095 LKQ-----------SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2143
Query: 1106 ELKVPKDRPQGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSGDPHGKC- 1164
E++ K + + R K T L+ + H + D L + + +
Sbjct: 2144 EMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNLLDEELQRLKAEATEAARQRS 2202
Query: 1165 -----LFDSYRLHDESNQRTLTLSSSKDANILSEQMSLKEVLDASVKEVGSSSSDVSGKE 1219
LF +E ++ + + A IL ++ + + L +++ + + + +
Sbjct: 2203 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA-RL 2261
Query: 1220 SVPVEEPLRSRASLIEVDLSDLKAPDED---------GELVSLDGSADLVSEGDQ--KPG 1268
SV +E R R L E DL+ +A E E L A+L+ + + +
Sbjct: 2262 SVAAQEAARLR-QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2320
Query: 1269 VGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVE--------LKRDEAR 1320
+D+++ +LA++ F QR E R R+ ++ AE E + R +AR
Sbjct: 2321 ARRLQEDKEQMAQQLAEETQGF----QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2376
Query: 1321 RKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKS 1363
+ + R RK+ E+ +L + E +++ +++ + + +S
Sbjct: 2377 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2419
Score = 35.4 bits (80), Expect = 0.45
Identities = 118/611 (19%), Positives = 238/611 (38%), Gaps = 89/611 (14%)
Query: 818 AERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTWRQKREQSPSQHGKDPASLLASE 877
AE ++Q+ S + + +K + E A + R+ RE++ + + LA E
Sbjct: 1964 AEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ--LAQE 2019
Query: 878 LVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPE-HFA 936
Q +Q EEK A Q+K+ E +Q L+ ++ + +G+AEAA E A
Sbjct: 2020 AAQKRLQAEEKAHAFAVQQKEQEL---QQTLQQEQSVLDQL--RGEAEAARRAAEEAEEA 2074
Query: 937 KEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQ--------DVDKESLAFAQQHKA- 987
+ ++ V + E E++ + + Q + ++E+ AQ +A
Sbjct: 2075 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2134
Query: 988 --KDPVALHELERNKVISAALLEDTVGEVVDVNECDLSIEK-------LNETI------- 1031
+ A E+E++K + L ++ L +E+ L+E +
Sbjct: 2135 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2194
Query: 1032 -------STLQQAILKISQQQEQLLMKSPTVPVPG------SKNNSQ---DHKVKAPVHF 1075
S +++ + + Q E+L + K+N+Q + +
Sbjct: 2195 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2254
Query: 1076 VEPLSPTGVAGHRKAPRLGQGRNSRSGRPAEL--KVPKDRPQGSSRSKTPTPSVETLPHL 1133
E + VA ++A RL Q + L K+ K++ Q + E L
Sbjct: 2255 AEEAARLSVAA-QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2313
Query: 1134 RPFPASSHPRTPTDPGLDSALEPSGDPHGKCLFDSYRLHDESNQRTLTLSSSKDA-NILS 1192
+ R D A + + + G R + QR L +S+ + +
Sbjct: 2314 KELAQEQARRLQEDKE-QMAQQLAEETQG-----FQRTLEAERQRQLEMSAEAERLKLRV 2367
Query: 1193 EQMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVS 1252
+MS + + ++ G++ E + + +L++ + D D E +
Sbjct: 2368 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2427
Query: 1253 LDGSADLVSEGD--QKPGVGFFFKDEQKA---EDELAKKRAAF----------LLKQQRK 1297
+ A+L E + Q+ K E+ +++L ++ A LL+++R
Sbjct: 2428 -EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2486
Query: 1298 AEEARVRKQQL----EAEVELKRDEARR---KAEEDR---VRKEEEKARRELIKQEYLRR 1347
E+ + + +QL A+ + R+E +R + E++R V EE RR+ +E +RR
Sbjct: 2487 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2546
Query: 1348 KQQQI--LEEQ 1356
KQ+++ LE+Q
Sbjct: 2547 KQEELQQLEQQ 2557
Score = 33.1 bits (74), Expect = 2.2
Identities = 31/131 (23%), Positives = 61/131 (46%), Gaps = 13/131 (9%)
Query: 1205 VKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLVSEGD 1264
+K + + + +E + ++ R L EV+ A ++ +L A +E +
Sbjct: 1312 IKFISETLRRMEEEERLAEQQRAEERERLAEVEA----ALEKQRQLAEAHAQAKAQAERE 1367
Query: 1265 QKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKA--EEARVRKQQLEAEVELKRDEARRK 1322
K ++ E+ + ++ AA +QQ+++ EE + +Q EAE++ K +A
Sbjct: 1368 AKE------LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA-EA 1420
Query: 1323 AEEDRVRKEEE 1333
AE R+R EEE
Sbjct: 1421 AERSRLRIEEE 1431
Score = 32.3 bits (72), Expect = 3.8
Identities = 24/96 (25%), Positives = 44/96 (45%), Gaps = 7/96 (7%)
Query: 1320 RRKAEEDRVRKEEEKARRE-LIKQEYLRRKQQQILEEQGLGK------PKSKPKKPRPKS 1372
RR EE+R+ +++ RE L + E KQ+Q+ E K K ++ + +
Sbjct: 1320 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1379
Query: 1373 VHREESCSDSGTKCSSTPDNLSRTQSGSSLSLASAA 1408
V REE+ D+ + S + L + + S + + A
Sbjct: 1380 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1415
Score = 32.3 bits (72), Expect = 3.8
Identities = 47/206 (22%), Positives = 82/206 (39%), Gaps = 41/206 (19%)
Query: 1192 SEQMSLKEVLDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELV 1251
S Q L+++ +S E+ + + E + R ++++ ++ + +GEL
Sbjct: 1395 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1454
Query: 1252 SLDGSAD-------------------LVSEGDQKPGVGFFFKDEQKAEDELA--KKRAAF 1290
+L A+ + E +K KAE E A K+RA
Sbjct: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1514
Query: 1291 LLKQQR-KAEEARVRKQQLEAE----VELKRDEARRKAEEDRVRK--------------- 1330
L++ R +AEEA R +Q E E V++ + A+R AE + K
Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574
Query: 1331 EEEKARRELIKQEYLRRKQQQILEEQ 1356
+EE +++E RR QQQ E+
Sbjct: 1575 QEEHVAVAQLREEAERRAQQQAEAER 1600
Score = 32.0 bits (71), Expect = 4.9
Identities = 27/86 (31%), Positives = 49/86 (56%), Gaps = 11/86 (12%)
Query: 1274 KDEQKAEDELAKKRAAFLLKQQRKAE-EARVRKQQLEAEVELK-RDEARRKAEEDRVRKE 1331
++E+ AE + A++R +R AE EA + KQ+ AE + + +A R+A+E + R +
Sbjct: 1324 EEERLAEQQRAEER-------ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1376
Query: 1332 EEKARRE--LIKQEYLRRKQQQILEE 1355
EE RRE + + +R Q+ L++
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQ 1402
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,843,514
Number of Sequences: 37866
Number of extensions: 3434690
Number of successful extensions: 21857
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 226
Number of HSP's successfully gapped in prelim test: 743
Number of HSP's that attempted gapping in prelim test: 14576
Number of HSP's gapped (non-prelim): 5130
length of query: 1602
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1486
effective length of database: 13,855,062
effective search space: 20588622132
effective search space used: 20588622132
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.