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Search of human proteins with 18426913
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18426913 drebrin 1 isoform b [Homo sapiens]
(651 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18426913 drebrin 1 isoform b [Homo sapiens] 1317 0.0
gi|18426915 drebrin 1 isoform a [Homo sapiens] 1251 0.0
gi|171906575 drebrin-like isoform c [Homo sapiens] 203 5e-52
gi|62198235 drebrin-like isoform b [Homo sapiens] 198 1e-50
gi|21361670 drebrin-like isoform a [Homo sapiens] 197 3e-50
gi|56549694 enabled homolog isoform a [Homo sapiens] 93 7e-19
gi|39930375 enabled homolog isoform b [Homo sapiens] 93 7e-19
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 71 3e-12
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 70 8e-12
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 67 5e-11
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 67 5e-11
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 67 5e-11
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 67 7e-11
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 67 7e-11
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 67 7e-11
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 67 7e-11
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 66 9e-11
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 65 1e-10
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 65 1e-10
gi|239752551 PREDICTED: hypothetical protein [Homo sapiens] 65 2e-10
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 65 2e-10
gi|55741677 SET domain containing 1A [Homo sapiens] 65 2e-10
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens] 65 3e-10
gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo sapi... 64 3e-10
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap... 64 4e-10
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C... 64 4e-10
gi|148746195 trichohyalin [Homo sapiens] 64 4e-10
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 64 6e-10
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 64 6e-10
gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo sapi... 64 6e-10
>gi|18426913 drebrin 1 isoform b [Homo sapiens]
Length = 651
Score = 1317 bits (3408), Expect = 0.0
Identities = 651/651 (100%), Positives = 651/651 (100%)
Query: 1 MAGHPWHGTAALASSQAWRDGRERQALVSCRALYTYEDGSDDLKLAASGEGGLQELSGHF 60
MAGHPWHGTAALASSQAWRDGRERQALVSCRALYTYEDGSDDLKLAASGEGGLQELSGHF
Sbjct: 1 MAGHPWHGTAALASSQAWRDGRERQALVSCRALYTYEDGSDDLKLAASGEGGLQELSGHF 60
Query: 61 ENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNA 120
ENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNA
Sbjct: 61 ENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNA 120
Query: 121 SSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINRE 180
SSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINRE
Sbjct: 121 SSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINRE 180
Query: 181 QFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRK 240
QFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRK
Sbjct: 181 QFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRK 240
Query: 241 QQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQE 300
QQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQE
Sbjct: 241 QQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQE 300
Query: 301 RVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDE 360
RVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDE
Sbjct: 301 RVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDE 360
Query: 361 VTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPA 420
VTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPA
Sbjct: 361 VTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPA 420
Query: 421 EDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDL 480
EDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDL
Sbjct: 421 EDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDL 480
Query: 481 WPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPE 540
WPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPE
Sbjct: 481 WPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPE 540
Query: 541 PPATFCDPEEVEGEPLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYF 600
PPATFCDPEEVEGEPLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYF
Sbjct: 541 PPATFCDPEEVEGEPLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYF 600
Query: 601 SQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD 651
SQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD
Sbjct: 601 SQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD 651
>gi|18426915 drebrin 1 isoform a [Homo sapiens]
Length = 649
Score = 1251 bits (3237), Expect = 0.0
Identities = 620/620 (100%), Positives = 620/620 (100%)
Query: 32 ALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGED 91
ALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGED
Sbjct: 30 ALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGED 89
Query: 92 VPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLR 151
VPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLR
Sbjct: 90 VPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLR 149
Query: 152 LREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQE 211
LREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQE
Sbjct: 150 LREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQE 209
Query: 212 RMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHM 271
RMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHM
Sbjct: 210 RMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHM 269
Query: 272 KKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMA 331
KKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMA
Sbjct: 270 KKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMA 329
Query: 332 PTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEET 391
PTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEET
Sbjct: 330 PTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEET 389
Query: 392 RAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDA 451
RAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDA
Sbjct: 390 RAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDA 449
Query: 452 ADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEV 511
ADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEV
Sbjct: 450 ADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEV 509
Query: 512 PLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGEPLAAPQTPTLPSALEEL 571
PLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGEPLAAPQTPTLPSALEEL
Sbjct: 510 PLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGEPLAAPQTPTLPSALEEL 569
Query: 572 EQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEID 631
EQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEID
Sbjct: 570 EQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEID 629
Query: 632 ITCWDADPVPEEEEGFEGGD 651
ITCWDADPVPEEEEGFEGGD
Sbjct: 630 ITCWDADPVPEEEEGFEGGD 649
>gi|171906575 drebrin-like isoform c [Homo sapiens]
Length = 439
Score = 203 bits (516), Expect = 5e-52
Identities = 121/344 (35%), Positives = 188/344 (54%), Gaps = 33/344 (9%)
Query: 32 ALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGED 91
AL+TYE S+D+++A +GEGGL+E+ + KVMY FC VKD + LPK+VLINW GE
Sbjct: 29 ALFTYEGNSNDIRVAGTGEGGLEEMVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEG 88
Query: 92 VPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLR 151
V D RK ACASHV+ +A F +G V +NA + ED++ I ++++ S R
Sbjct: 89 VNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGR 148
Query: 152 LREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQE 211
++ PVG+ YQKT+A E+KR+ ++ FW +A+KEEE R+ EE+++A + + + EQE
Sbjct: 149 FQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQE 208
Query: 212 RMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHM 271
R E+E +E RE+RY+E+ + R + ++Q + +R+E+ T
Sbjct: 209 RRERELREAARREQRYQEQGGEASPQSRTWE-----------QQQEVVSRNRNEQGSTCA 257
Query: 272 KKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVP----SPFNHRPGSHLDSH 327
ES V +PRE FKQ+ER S ++ S P SPF + + ++H
Sbjct: 258 SLQESAV------------HPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETH 305
Query: 328 RRMAPTPIPTRS----PSDSSTASTPVAEQIERALDEVTSSQPP 367
P +R P++ STP + +A +E +PP
Sbjct: 306 FGREPAAAISRPRADLPAEEPAPSTPPC--LVQAEEEAVYEEPP 347
>gi|62198235 drebrin-like isoform b [Homo sapiens]
Length = 430
Score = 198 bits (504), Expect = 1e-50
Identities = 119/344 (34%), Positives = 185/344 (53%), Gaps = 42/344 (12%)
Query: 32 ALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGED 91
AL+TYE S+D+++A +GEGGL+E+ + KVMY FC VKD + LPK+VLINW GE
Sbjct: 29 ALFTYEGNSNDIRVAGTGEGGLEEMVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEG 88
Query: 92 VPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLR 151
V D RK ACASHV+ +A F +G V +NA + ED++ I ++++ S R
Sbjct: 89 VNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGR 148
Query: 152 LREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQE 211
++ PVG+ YQKT+A E+KR+ ++ FW +A+KEEE R+ EE+++A + + + EQE
Sbjct: 149 FQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQE 208
Query: 212 RMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHM 271
R E+E +E RE+RY+E+ + R +Q +Q + +R+E+E
Sbjct: 209 RRERELREAARREQRYQEQGGEASPQRTWEQ------------QQEVVSRNRNEQESA-- 254
Query: 272 KKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVP----SPFNHRPGSHLDSH 327
+PRE FKQ+ER S ++ S P SPF + + ++H
Sbjct: 255 ------------------VHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETH 296
Query: 328 RRMAPTPIPTRS----PSDSSTASTPVAEQIERALDEVTSSQPP 367
P +R P++ STP + +A +E +PP
Sbjct: 297 FGREPAAAISRPRADLPAEEPAPSTPPC--LVQAEEEAVYEEPP 338
>gi|21361670 drebrin-like isoform a [Homo sapiens]
Length = 431
Score = 197 bits (501), Expect = 3e-50
Identities = 118/344 (34%), Positives = 185/344 (53%), Gaps = 41/344 (11%)
Query: 32 ALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGED 91
AL+TYE S+D+++A +GEGGL+E+ + KVMY FC VKD + LPK+VLINW GE
Sbjct: 29 ALFTYEGNSNDIRVAGTGEGGLEEMVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEG 88
Query: 92 VPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLR 151
V D RK ACASHV+ +A F +G V +NA + ED++ I ++++ S R
Sbjct: 89 VNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGR 148
Query: 152 LREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQE 211
++ PVG+ YQKT+A E+KR+ ++ FW +A+KEEE R+ EE+++A + + + EQE
Sbjct: 149 FQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQE 208
Query: 212 RMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHM 271
R E+E +E RE+RY+E+ + R + ++Q + +R+E+E
Sbjct: 209 RRERELREAARREQRYQEQGGEASPQSRTWE-----------QQQEVVSRNRNEQESA-- 255
Query: 272 KKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVP----SPFNHRPGSHLDSH 327
+PRE FKQ+ER S ++ S P SPF + + ++H
Sbjct: 256 ------------------VHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETH 297
Query: 328 RRMAPTPIPTRS----PSDSSTASTPVAEQIERALDEVTSSQPP 367
P +R P++ STP + +A +E +PP
Sbjct: 298 FGREPAAAISRPRADLPAEEPAPSTPPC--LVQAEEEAVYEEPP 339
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 93.2 bits (230), Expect = 7e-19
Identities = 98/374 (26%), Positives = 151/374 (40%), Gaps = 43/374 (11%)
Query: 143 SSPVLHRLRLREDENAEPVGTTYQKTDAAV----------EMKRINREQFWEQAKKEEEL 192
+S ++H L + N++ G T + ++ + E I R Q EQ +++E
Sbjct: 101 ASAMMHALEVL---NSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELE 157
Query: 193 RKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRR 252
R+ ER++ ER R E+ER+E+ER E+E E+ ERE+Q E + + + E E + R
Sbjct: 158 RERLERERM--ERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQER 215
Query: 253 LKEQSIFGDHRDE-EEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCD 311
L+ Q R E +E +++ E E +E Q + ++ER S++A
Sbjct: 216 LERQERLDRERQERQERERLERLERERQERE---RQEQLEREQLEWERERRISSAAAPAS 272
Query: 312 VPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERAL-----DEVTSSQP 366
V +P N G S + P +PS P+A L + P
Sbjct: 273 VETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPP 332
Query: 367 PPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFM 426
PP PPPPPP T P P P P + PP PP P PA
Sbjct: 333 PPGPPPPPPLPSTGPPPP-----------PPPPPLPNQVPPPPPPPP-APPLPASGFFLA 380
Query: 427 ESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGE 486
+E + A A A ++ + +T + + N +A+S D GNG
Sbjct: 381 SMSEDNRPLTGLAAAIAGA-KLRKVSRMEDTSFPSGGNAIGVN---SASSKTDTGRGNGP 436
Query: 487 ---GASTLQGEPRA 497
G S L E A
Sbjct: 437 LPLGGSGLMEEMSA 450
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 93.2 bits (230), Expect = 7e-19
Identities = 98/374 (26%), Positives = 151/374 (40%), Gaps = 43/374 (11%)
Query: 143 SSPVLHRLRLREDENAEPVGTTYQKTDAAV----------EMKRINREQFWEQAKKEEEL 192
+S ++H L + N++ G T + ++ + E I R Q EQ +++E
Sbjct: 101 ASAMMHALEVL---NSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELE 157
Query: 193 RKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRR 252
R+ ER++ ER R E+ER+E+ER E+E E+ ERE+Q E + + + E E + R
Sbjct: 158 RERLERERM--ERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQER 215
Query: 253 LKEQSIFGDHRDE-EEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCD 311
L+ Q R E +E +++ E E +E Q + ++ER S++A
Sbjct: 216 LERQERLDRERQERQERERLERLERERQERE---RQEQLEREQLEWERERRISSAAAPAS 272
Query: 312 VPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERAL-----DEVTSSQP 366
V +P N G S + P +PS P+A L + P
Sbjct: 273 VETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPP 332
Query: 367 PPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFM 426
PP PPPPPP T P P P P + PP PP P PA
Sbjct: 333 PPGPPPPPPLPSTGPPPP-----------PPPPPLPNQVPPPPPPPP-APPLPASGFFLA 380
Query: 427 ESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGE 486
+E + A A A ++ + +T + + N +A+S D GNG
Sbjct: 381 SMSEDNRPLTGLAAAIAGA-KLRKVSRMEDTSFPSGGNAIGVN---SASSKTDTGRGNGP 436
Query: 487 ---GASTLQGEPRA 497
G S L E A
Sbjct: 437 LPLGGSGLMEEMSA 450
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 71.2 bits (173), Expect = 3e-12
Identities = 103/484 (21%), Positives = 182/484 (37%), Gaps = 54/484 (11%)
Query: 126 IDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQ 185
I G I L GL ++ S H ++++ +E + V + ++T + ++ Q E+
Sbjct: 413 IGFGPIPFSLPEGLPKIPSVSTH-IKVKSEEKIKVVEKSEKET--VIVEEQTEETQVTEE 469
Query: 186 AKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQI----------- 234
+EEE +EE K + E E E+E + E E+E +
Sbjct: 470 VTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAE 529
Query: 235 ------EEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMK-----KSESEVEEAAA 283
EE + + E+AK KE++ E+ K KS + + A
Sbjct: 530 AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAK 589
Query: 284 IIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHR---PGSHLDSHRRMAPTPIPTRSP 340
A+ P + K + V + + SP P + +PT +SP
Sbjct: 590 EEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSP 649
Query: 341 SDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWA 400
+ + A+ E+A V + P P E + P + A +P+
Sbjct: 650 EKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAK 709
Query: 401 GPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTA 460
P++E +A++P + E+ E A+ V P A + E A T++ +
Sbjct: 710 SPVKE--EAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPE---KAKTLDVKSP 764
Query: 461 TADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEV-AP 519
A T A S D +P + S ++ E ++P A+ PL ++ AP
Sbjct: 765 EAKTPAKEE----ARSPADKFPEKAK--SPVKEEVKSPEK--------AKSPLKEDAKAP 810
Query: 520 EPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGEPLAAPQTPTL----PSALEELEQEQ 575
E +P E + + +E P+ P++ E E AP TP S EE +++
Sbjct: 811 EKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEE--KAPATPKTEEKKDSKKEEAPKKE 868
Query: 576 EPEP 579
P+P
Sbjct: 869 APKP 872
Score = 35.8 bits (81), Expect = 0.13
Identities = 33/133 (24%), Positives = 63/133 (47%), Gaps = 14/133 (10%)
Query: 154 EDENAEPVGTTYQKTDAAVEMKR-INREQFWEQAKKEEELRKEEERKKALDERLRFEQER 212
E E+ + V T ++ A VE+K ++ E AKKE + K +E K +++ E
Sbjct: 896 EAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKK-----EA 950
Query: 213 MEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLK--EQSIFGDHRDEEEETH 270
+++ +EE+ ++ E+ + + + +TL E +K + + E+S D +D
Sbjct: 951 APEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDS----- 1005
Query: 271 MKKSESEVEEAAA 283
K E E+ AA
Sbjct: 1006 -KPPEKATEDKAA 1017
Score = 33.9 bits (76), Expect = 0.48
Identities = 34/173 (19%), Positives = 81/173 (46%), Gaps = 23/173 (13%)
Query: 142 LSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELR-KEEERKK 200
+ SPV + +E + EP ++ A ++ E+A K+E + K EE+K+
Sbjct: 820 VKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKE 879
Query: 201 ALDERLRFEQERMEQERQEQEER------ERRYREREQQIEEHRRKQQT---------LE 245
E+ + + ++E +++E E++ E+ + + E+ + K++T +
Sbjct: 880 PAVEKPK--ESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAK 937
Query: 246 AEEAKRRLKEQSIFGDHRDEEEETHMK-----KSESEVEEAAAIIAQRPDNPR 293
A+E + +++ + +D +EE K K+E++ +E +++ P P+
Sbjct: 938 AKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPK 990
Score = 32.3 bits (72), Expect = 1.4
Identities = 47/247 (19%), Positives = 95/247 (38%), Gaps = 35/247 (14%)
Query: 171 AVEMKRINREQFWEQAKK--EEELRKEEERKKALDERLRFEQERMEQE-------RQEQE 221
A E R ++F E+AK +EE++ E+ K L E + ++ + ++ ++E++
Sbjct: 770 AKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829
Query: 222 ERERRYREREQQIEEHR--------RKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKK 273
+E + +E ++ EE + K+ + + E K+ + + E+ K
Sbjct: 830 PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESK 889
Query: 274 SESEVEEA---AAIIAQRPDNP-----REFFKQQERVASASAGSCDVPSPFNHRPGSHLD 325
E++ EEA + + P +E K +E+ A D + +P
Sbjct: 890 VEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPA---- 945
Query: 326 SHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPI 385
+ AP T+ P E + D+ S + P P E E S
Sbjct: 946 EKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKE------PSKPKAEKAEKSSS 999
Query: 386 LDSEETR 392
D ++++
Sbjct: 1000 TDQKDSK 1006
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 69.7 bits (169), Expect = 8e-12
Identities = 66/299 (22%), Positives = 128/299 (42%), Gaps = 52/299 (17%)
Query: 166 QKTDAAVEMKRINREQFWEQ--------AKKEEELRKEEERKKALDERLRFEQERMEQER 217
++++A + + +Q EQ A++++ + +++E+++ L+E+ R E+E Q+
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 218 QEQEERERRYREREQQIEEHRRKQQTLE-AEEAKRRLKEQSIFGDHRDEEEETHMKKSES 276
+EQ RE+ + R +++E R++++ AEE KRR++ + + + EEE+ H++ +
Sbjct: 425 REQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQ 484
Query: 277 EV--EEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNH---------------- 318
++ E+A + R +P+ + S S P P H
Sbjct: 485 QLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRK 544
Query: 319 ----RPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPP 374
P + R+ P+P+RS S S+ S V ++R P P
Sbjct: 545 TNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQR-------------PAEPQ 591
Query: 375 PAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAV 433
T SP+L +R +P +G +QA R S E + E E+ V
Sbjct: 592 VPVRTTSRSPVL----SRRDSPLQGSGQQ----NSQAGQRNSTSSIEPRLLWERVEKLV 642
Score = 48.1 bits (113), Expect = 2e-05
Identities = 34/124 (27%), Positives = 67/124 (54%), Gaps = 9/124 (7%)
Query: 184 EQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRY-REREQQIEEHRRKQQ 242
E + + LR ++E K+ E LR +Q EQ+ +EQEE +R+ ER+++IE+ + +++
Sbjct: 349 ESTLRRDFLRLQQENKER-SEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRR 407
Query: 243 TLEAEEAKRR--LKEQSIFGDHRDEE-----EETHMKKSESEVEEAAAIIAQRPDNPREF 295
LE ++ + R ++Q R++E EE ++ E E A +R + +E+
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEY 467
Query: 296 FKQQ 299
++Q
Sbjct: 468 IRRQ 471
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 67.0 bits (162), Expect = 5e-11
Identities = 77/369 (20%), Positives = 146/369 (39%), Gaps = 63/369 (17%)
Query: 166 QKTDAAVEMKRINREQFWEQ--------AKKEEELRKEEERKKALDERLRFEQERMEQER 217
++++A + + +Q EQ A++++ + +++E+++ L+E+ R E+E Q+
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 218 QEQEERERRYREREQQIEEHRRKQQTLE-AEEAKRRLKEQSIFGDHRDEEEETHMKKSES 276
+EQ RE+ + R +++E R++++ AEE KRR++ + + + EEE+ H++ +
Sbjct: 425 REQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQ 484
Query: 277 EVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIP 336
++ + A++ + E +Q ER+ H HRR P P
Sbjct: 485 QLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQH-------DHRR--PHPQH 535
Query: 337 TRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAP 396
++ P PPP P+ EP + +
Sbjct: 536 SQQP-------------------------PPPQQERSKPSFHAPEPKAHYEPADRAREVE 570
Query: 397 QAWAGPMEEPPQAQAPPRG----PGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAA 452
+ P+AQ+ G P P+ F ++V A PA H A
Sbjct: 571 DRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVQWSHLA- 629
Query: 453 DTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVP 512
++ NNV P + S P L+ + P PPS +EV L++
Sbjct: 630 ------------SLKNNVSPVSRSHSFSDPSPKFAHHHLRSQD--PCPPSRSEV-LSQSS 674
Query: 513 LLDEVAPEP 521
AP+P
Sbjct: 675 DSKSEAPDP 683
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 67.0 bits (162), Expect = 5e-11
Identities = 57/151 (37%), Positives = 82/151 (54%), Gaps = 24/151 (15%)
Query: 179 REQFWEQAKKEEE---LRKEEERKKALDERL--RFEQERMEQERQEQE--ERERRYRERE 231
R Q Q KKEEE LRK E K+ ++R R EQER EQER+EQE E+ERR +ER+
Sbjct: 659 RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQ 718
Query: 232 QQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDN 291
+E RR+Q+ L+AE R L+E R++ ++ + E+EE Q+
Sbjct: 719 LAEQERRREQERLQAE---RELQE-------REKALRLQKEQLQRELEEKKKKEEQQRLA 768
Query: 292 PREFFKQQERVASASAG-------SCDVPSP 315
R+ ++QE+ A +AG + DV SP
Sbjct: 769 ERQLQEEQEKKAKEAAGASKALNVTVDVQSP 799
Score = 57.4 bits (137), Expect = 4e-08
Identities = 38/109 (34%), Positives = 65/109 (59%), Gaps = 8/109 (7%)
Query: 171 AVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERM--EQERQEQEER---ER 225
A E KR+ ++ EQ ++E+E R++E R++ E+ R EQER EQER+ ++ER ER
Sbjct: 678 AAEAKRLAEQR--EQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAER 735
Query: 226 RYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKS 274
+ERE+ + + + Q E EE K++ ++Q + EE+E K++
Sbjct: 736 ELQEREKALRLQKEQLQR-ELEEKKKKEEQQRLAERQLQEEQEKKAKEA 783
Score = 49.3 bits (116), Expect = 1e-05
Identities = 51/202 (25%), Positives = 90/202 (44%), Gaps = 45/202 (22%)
Query: 147 LHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAK------KEEELRKEEERKK 200
L ++L+ +E V ++ + E K+ EQ + Q KEE L +E+ +KK
Sbjct: 567 LEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKK 626
Query: 201 ALDERLRFEQERMEQERQ-------EQEERERRYRE------------------------ 229
A +++ + R +QE + +QEE ERR++E
Sbjct: 627 AAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAE 686
Query: 230 -REQQI-EEHRRKQQTLEAE--EAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAII 285
REQ+ E+ RR+Q+ E E E +RR +E+ + R E+E + E + E A +
Sbjct: 687 QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRL 746
Query: 286 ----AQRPDNPREFFKQQERVA 303
QR ++ ++Q+R+A
Sbjct: 747 QKEQLQRELEEKKKKEEQQRLA 768
Score = 48.5 bits (114), Expect = 2e-05
Identities = 31/106 (29%), Positives = 58/106 (54%), Gaps = 5/106 (4%)
Query: 180 EQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEE--H 237
EQ Q +E++ R+ EE K +ERLR + E+ Q +EE++++ ++ QI+E
Sbjct: 552 EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTE 611
Query: 238 RRKQQTLEAEEAKRRL---KEQSIFGDHRDEEEETHMKKSESEVEE 280
+ K++ L E+AK++ K + + + EEE ++ + E EE
Sbjct: 612 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEE 657
Score = 43.5 bits (101), Expect = 6e-04
Identities = 33/124 (26%), Positives = 66/124 (53%), Gaps = 13/124 (10%)
Query: 184 EQAKKEEELRKEEE----RKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRR 239
++ ++ E LR++EE R++ ++E R E ++ +R+E+ + + RER +Q++E ++
Sbjct: 537 KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKK 596
Query: 240 K---QQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFF 296
K Q+ + +E + KE+ R EE+ K + ++EE A Q + R +
Sbjct: 597 KQIEQKFAQIDEKTEKAKEE------RLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 650
Query: 297 KQQE 300
QQE
Sbjct: 651 LQQE 654
Score = 38.1 bits (87), Expect = 0.026
Identities = 29/91 (31%), Positives = 48/91 (52%), Gaps = 6/91 (6%)
Query: 195 EEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLK 254
E+ER++ E LR ++E + RQ+ EE +RR R E +++ R ++ L+A E ++K
Sbjct: 536 EKERQRL--ENLRRKEEAEQLRRQKVEEDKRR-RLEEVKLKREERLRKVLQARERVEQMK 592
Query: 255 EQ---SIFGDHRDEEEETHMKKSESEVEEAA 282
E+ I +E+T K E EE A
Sbjct: 593 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKA 623
Score = 37.4 bits (85), Expect = 0.044
Identities = 49/214 (22%), Positives = 87/214 (40%), Gaps = 41/214 (19%)
Query: 190 EELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEA 249
EE+++E ER E E M + ++ R++R R +++ R +
Sbjct: 35 EEIQEEAERM--FTREFSKEPELMPKTPSQKNRRKKR---RISYVQDENR-------DPI 82
Query: 250 KRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGS 309
+RRL + R + + +S+ VE+ A ++ + N + A+A+A +
Sbjct: 83 RRRLSRRK----SRSSQLSSRRLRSKDSVEKLATVVGE---NGSVLRRVTRAAAAAAAAT 135
Query: 310 CDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTAS--TPVAE-------QIERALDE 360
+ +P + P S PT + T+ P D+ T PV E E+ + +
Sbjct: 136 MALAAPSSPTPES---------PTML-TKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQ 185
Query: 361 VTSSQPPPLPPPPPPAQETQEPS---PILDSEET 391
+ S++P P P PA T S P D E T
Sbjct: 186 LMSTEPLPRTLSPTPASATAPTSQGIPTSDEEST 219
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 67.0 bits (162), Expect = 5e-11
Identities = 57/151 (37%), Positives = 82/151 (54%), Gaps = 24/151 (15%)
Query: 179 REQFWEQAKKEEE---LRKEEERKKALDERL--RFEQERMEQERQEQE--ERERRYRERE 231
R Q Q KKEEE LRK E K+ ++R R EQER EQER+EQE E+ERR +ER+
Sbjct: 655 RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQ 714
Query: 232 QQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDN 291
+E RR+Q+ L+AE R L+E R++ ++ + E+EE Q+
Sbjct: 715 LAEQERRREQERLQAE---RELQE-------REKALRLQKEQLQRELEEKKKKEEQQRLA 764
Query: 292 PREFFKQQERVASASAG-------SCDVPSP 315
R+ ++QE+ A +AG + DV SP
Sbjct: 765 ERQLQEEQEKKAKEAAGASKALNVTVDVQSP 795
Score = 57.4 bits (137), Expect = 4e-08
Identities = 38/109 (34%), Positives = 65/109 (59%), Gaps = 8/109 (7%)
Query: 171 AVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERM--EQERQEQEER---ER 225
A E KR+ ++ EQ ++E+E R++E R++ E+ R EQER EQER+ ++ER ER
Sbjct: 674 AAEAKRLAEQR--EQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAER 731
Query: 226 RYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKS 274
+ERE+ + + + Q E EE K++ ++Q + EE+E K++
Sbjct: 732 ELQEREKALRLQKEQLQR-ELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
Score = 49.3 bits (116), Expect = 1e-05
Identities = 51/202 (25%), Positives = 90/202 (44%), Gaps = 45/202 (22%)
Query: 147 LHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAK------KEEELRKEEERKK 200
L ++L+ +E V ++ + E K+ EQ + Q KEE L +E+ +KK
Sbjct: 563 LEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKK 622
Query: 201 ALDERLRFEQERMEQERQ-------EQEERERRYRE------------------------ 229
A +++ + R +QE + +QEE ERR++E
Sbjct: 623 AAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAE 682
Query: 230 -REQQI-EEHRRKQQTLEAE--EAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAII 285
REQ+ E+ RR+Q+ E E E +RR +E+ + R E+E + E + E A +
Sbjct: 683 QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRL 742
Query: 286 ----AQRPDNPREFFKQQERVA 303
QR ++ ++Q+R+A
Sbjct: 743 QKEQLQRELEEKKKKEEQQRLA 764
Score = 48.5 bits (114), Expect = 2e-05
Identities = 31/106 (29%), Positives = 58/106 (54%), Gaps = 5/106 (4%)
Query: 180 EQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEE--H 237
EQ Q +E++ R+ EE K +ERLR + E+ Q +EE++++ ++ QI+E
Sbjct: 548 EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTE 607
Query: 238 RRKQQTLEAEEAKRRL---KEQSIFGDHRDEEEETHMKKSESEVEE 280
+ K++ L E+AK++ K + + + EEE ++ + E EE
Sbjct: 608 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEE 653
Score = 43.1 bits (100), Expect = 8e-04
Identities = 35/138 (25%), Positives = 70/138 (50%), Gaps = 12/138 (8%)
Query: 166 QKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERER 225
+ T ++ K R++ E +++EE + +K D+R R E+ ++ +R+E+ +
Sbjct: 522 RNTPLRMDPKEKERQRL-ENLRRKEEAEQLRRQKVEEDKRRRLEEVKL--KREERLRKVL 578
Query: 226 RYREREQQIEEHRRK---QQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAA 282
+ RER +Q++E ++K Q+ + +E + KE+ R EE+ K + ++EE
Sbjct: 579 QARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEE------RLAEEKAKKKAAAKKMEEVE 632
Query: 283 AIIAQRPDNPREFFKQQE 300
A Q + R + QQE
Sbjct: 633 ARRKQEEEARRLRWLQQE 650
Score = 37.4 bits (85), Expect = 0.044
Identities = 49/214 (22%), Positives = 87/214 (40%), Gaps = 41/214 (19%)
Query: 190 EELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEA 249
EE+++E ER E E M + ++ R++R R +++ R +
Sbjct: 35 EEIQEEAERM--FTREFSKEPELMPKTPSQKNRRKKR---RISYVQDENR-------DPI 82
Query: 250 KRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGS 309
+RRL + R + + +S+ VE+ A ++ + N + A+A+A +
Sbjct: 83 RRRLSRRK----SRSSQLSSRRLRSKDSVEKLATVVGE---NGSVLRRVTRAAAAAAAAT 135
Query: 310 CDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTAS--TPVAE-------QIERALDE 360
+ +P + P S PT + T+ P D+ T PV E E+ + +
Sbjct: 136 MALAAPSSPTPES---------PTML-TKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQ 185
Query: 361 VTSSQPPPLPPPPPPAQETQEPS---PILDSEET 391
+ S++P P P PA T S P D E T
Sbjct: 186 LMSTEPLPRTLSPTPASATAPTSQGIPTSDEEST 219
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 66.6 bits (161), Expect = 7e-11
Identities = 47/158 (29%), Positives = 78/158 (49%), Gaps = 21/158 (13%)
Query: 177 INREQFWEQAKKEEE----LRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQ 232
+ R+Q E+ ++EEE ++EE ++ ++ + ++R E+ERQ+QEE RR ER +
Sbjct: 763 LRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR 822
Query: 233 QIEEHRRKQQTL-------------EAEEAKRRLKEQSIFGDH---RDEEEETHMKKSES 276
+ EE RRKQ+ L E EEA+RRL+E + + R EE K+ E
Sbjct: 823 E-EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKEL 881
Query: 277 EVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPS 314
EV+ ++ QR + Q++ +PS
Sbjct: 882 EVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPS 919
Score = 64.3 bits (155), Expect = 3e-10
Identities = 49/160 (30%), Positives = 88/160 (55%), Gaps = 14/160 (8%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEE---RKKALDERLR 207
+L++ E A+ ++ +A + KR E+ K++EELR+++E R++ +ER R
Sbjct: 719 QLQQLEKAKAAKLEQERREAEMRAKREEEER-----KRQEELRRQQEEILRRQQEEERKR 773
Query: 208 FEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEE 267
E+E E R++QEE RR RE+E + R +++ + EEA RRL+E+ + R ++E
Sbjct: 774 REEE--ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQE 831
Query: 268 ETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASA 307
E ++K E EEAA + + R + + R+ +A
Sbjct: 832 EL-LRKQE---EEAAKWAREEEEAQRRLEENRLRMEEEAA 867
Score = 50.4 bits (119), Expect = 5e-06
Identities = 42/119 (35%), Positives = 67/119 (56%), Gaps = 25/119 (21%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEEL------------RKEEER 198
R RE+E + Q+ +A ++ RE+ E+ +K+EEL R+EEE
Sbjct: 800 RQREEEERQ------QQEEALRRLEERRREE--EERRKQEELLRKQEEEAAKWAREEEEA 851
Query: 199 KKALDE-RLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQ 256
++ L+E RLR E+E R E+EER+R+ E ++Q E R++QQ +EA RRL++Q
Sbjct: 852 QRRLEENRLRMEEEAARL-RHEEEERKRKELEVQRQKELMRQRQQ---QQEALRRLQQQ 906
Score = 35.8 bits (81), Expect = 0.13
Identities = 36/188 (19%), Positives = 83/188 (44%), Gaps = 40/188 (21%)
Query: 153 REDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEE----RKKALDERLRF 208
+++E A ++ +E R+ E+ + + EEE RK +E R+K L + +
Sbjct: 836 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 895
Query: 209 EQERMEQERQEQEER---------------------------------ERRYREREQQIE 235
+QE + + +Q+Q+++ ++ ERE+Q+
Sbjct: 896 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 955
Query: 236 EHRRKQQ--TLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPR 293
E +R+QQ ++A + +++ ++Q + G + + + KS E+++ A Q+ +
Sbjct: 956 EEQRRQQRELMKALQQQQQQQQQKLSG-WGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQ 1014
Query: 294 EFFKQQER 301
+ +Q R
Sbjct: 1015 QQHQQPNR 1022
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 66.6 bits (161), Expect = 7e-11
Identities = 47/158 (29%), Positives = 78/158 (49%), Gaps = 21/158 (13%)
Query: 177 INREQFWEQAKKEEE----LRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQ 232
+ R+Q E+ ++EEE ++EE ++ ++ + ++R E+ERQ+QEE RR ER +
Sbjct: 790 LRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR 849
Query: 233 QIEEHRRKQQTL-------------EAEEAKRRLKEQSIFGDH---RDEEEETHMKKSES 276
+ EE RRKQ+ L E EEA+RRL+E + + R EE K+ E
Sbjct: 850 E-EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKEL 908
Query: 277 EVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPS 314
EV+ ++ QR + Q++ +PS
Sbjct: 909 EVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPS 946
Score = 64.3 bits (155), Expect = 3e-10
Identities = 49/160 (30%), Positives = 88/160 (55%), Gaps = 14/160 (8%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEE---RKKALDERLR 207
+L++ E A+ ++ +A + KR E+ K++EELR+++E R++ +ER R
Sbjct: 746 QLQQLEKAKAAKLEQERREAEMRAKREEEER-----KRQEELRRQQEEILRRQQEEERKR 800
Query: 208 FEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEE 267
E+E E R++QEE RR RE+E + R +++ + EEA RRL+E+ + R ++E
Sbjct: 801 REEE--ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQE 858
Query: 268 ETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASA 307
E ++K E EEAA + + R + + R+ +A
Sbjct: 859 EL-LRKQE---EEAAKWAREEEEAQRRLEENRLRMEEEAA 894
Score = 50.4 bits (119), Expect = 5e-06
Identities = 42/119 (35%), Positives = 67/119 (56%), Gaps = 25/119 (21%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEEL------------RKEEER 198
R RE+E + Q+ +A ++ RE+ E+ +K+EEL R+EEE
Sbjct: 827 RQREEEERQ------QQEEALRRLEERRREE--EERRKQEELLRKQEEEAAKWAREEEEA 878
Query: 199 KKALDE-RLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQ 256
++ L+E RLR E+E R E+EER+R+ E ++Q E R++QQ +EA RRL++Q
Sbjct: 879 QRRLEENRLRMEEEAARL-RHEEEERKRKELEVQRQKELMRQRQQ---QQEALRRLQQQ 933
Score = 35.8 bits (81), Expect = 0.13
Identities = 36/188 (19%), Positives = 83/188 (44%), Gaps = 40/188 (21%)
Query: 153 REDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEE----RKKALDERLRF 208
+++E A ++ +E R+ E+ + + EEE RK +E R+K L + +
Sbjct: 863 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 922
Query: 209 EQERMEQERQEQEER---------------------------------ERRYREREQQIE 235
+QE + + +Q+Q+++ ++ ERE+Q+
Sbjct: 923 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 982
Query: 236 EHRRKQQ--TLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPR 293
E +R+QQ ++A + +++ ++Q + G + + + KS E+++ A Q+ +
Sbjct: 983 EEQRRQQRELMKALQQQQQQQQQKLSG-WGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQ 1041
Query: 294 EFFKQQER 301
+ +Q R
Sbjct: 1042 QQHQQPNR 1049
Score = 33.5 bits (75), Expect = 0.63
Identities = 43/227 (18%), Positives = 82/227 (36%), Gaps = 50/227 (22%)
Query: 156 ENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQ 215
E+AE T+ + A + +K++ +E E+ +E + R +E ++ D +E E
Sbjct: 313 EDAEEEMGTFDSSGAFLSLKKVQKEPIPEE--QEMDFRPVDEGEECSDSEGSHNEEAKEP 370
Query: 216 ERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSE 275
++ ++E E+ R E + + +++ + +DE + +K+E
Sbjct: 371 DKTNKKEGEKTDRVGVASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAE 430
Query: 276 SEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPI 335
E ++ A+ P + E VA DV P + P
Sbjct: 431 EETRMENSLPAKVPS------RGDEMVA-------DVQQPLSQIP--------------- 462
Query: 336 PTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEP 382
S TAS + PPP+P P P + + P
Sbjct: 463 -------SDTASPLLI-------------LPPPVPNPSPTLRPVETP 489
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 66.6 bits (161), Expect = 7e-11
Identities = 47/158 (29%), Positives = 78/158 (49%), Gaps = 21/158 (13%)
Query: 177 INREQFWEQAKKEEE----LRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQ 232
+ R+Q E+ ++EEE ++EE ++ ++ + ++R E+ERQ+QEE RR ER +
Sbjct: 769 LRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR 828
Query: 233 QIEEHRRKQQTL-------------EAEEAKRRLKEQSIFGDH---RDEEEETHMKKSES 276
+ EE RRKQ+ L E EEA+RRL+E + + R EE K+ E
Sbjct: 829 E-EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKEL 887
Query: 277 EVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPS 314
EV+ ++ QR + Q++ +PS
Sbjct: 888 EVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPS 925
Score = 64.3 bits (155), Expect = 3e-10
Identities = 49/160 (30%), Positives = 88/160 (55%), Gaps = 14/160 (8%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEE---RKKALDERLR 207
+L++ E A+ ++ +A + KR E+ K++EELR+++E R++ +ER R
Sbjct: 725 QLQQLEKAKAAKLEQERREAEMRAKREEEER-----KRQEELRRQQEEILRRQQEEERKR 779
Query: 208 FEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEE 267
E+E E R++QEE RR RE+E + R +++ + EEA RRL+E+ + R ++E
Sbjct: 780 REEE--ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQE 837
Query: 268 ETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASA 307
E ++K E EEAA + + R + + R+ +A
Sbjct: 838 EL-LRKQE---EEAAKWAREEEEAQRRLEENRLRMEEEAA 873
Score = 50.4 bits (119), Expect = 5e-06
Identities = 42/119 (35%), Positives = 67/119 (56%), Gaps = 25/119 (21%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEEL------------RKEEER 198
R RE+E + Q+ +A ++ RE+ E+ +K+EEL R+EEE
Sbjct: 806 RQREEEERQ------QQEEALRRLEERRREE--EERRKQEELLRKQEEEAAKWAREEEEA 857
Query: 199 KKALDE-RLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQ 256
++ L+E RLR E+E R E+EER+R+ E ++Q E R++QQ +EA RRL++Q
Sbjct: 858 QRRLEENRLRMEEEAARL-RHEEEERKRKELEVQRQKELMRQRQQ---QQEALRRLQQQ 912
Score = 35.8 bits (81), Expect = 0.13
Identities = 36/188 (19%), Positives = 83/188 (44%), Gaps = 40/188 (21%)
Query: 153 REDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEE----RKKALDERLRF 208
+++E A ++ +E R+ E+ + + EEE RK +E R+K L + +
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901
Query: 209 EQERMEQERQEQEER---------------------------------ERRYREREQQIE 235
+QE + + +Q+Q+++ ++ ERE+Q+
Sbjct: 902 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 961
Query: 236 EHRRKQQ--TLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPR 293
E +R+QQ ++A + +++ ++Q + G + + + KS E+++ A Q+ +
Sbjct: 962 EEQRRQQRELMKALQQQQQQQQQKLSG-WGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQ 1020
Query: 294 EFFKQQER 301
+ +Q R
Sbjct: 1021 QQHQQPNR 1028
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 66.6 bits (161), Expect = 7e-11
Identities = 47/158 (29%), Positives = 78/158 (49%), Gaps = 21/158 (13%)
Query: 177 INREQFWEQAKKEEE----LRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQ 232
+ R+Q E+ ++EEE ++EE ++ ++ + ++R E+ERQ+QEE RR ER +
Sbjct: 769 LRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR 828
Query: 233 QIEEHRRKQQTL-------------EAEEAKRRLKEQSIFGDH---RDEEEETHMKKSES 276
+ EE RRKQ+ L E EEA+RRL+E + + R EE K+ E
Sbjct: 829 E-EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKEL 887
Query: 277 EVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPS 314
EV+ ++ QR + Q++ +PS
Sbjct: 888 EVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPS 925
Score = 64.3 bits (155), Expect = 3e-10
Identities = 49/160 (30%), Positives = 88/160 (55%), Gaps = 14/160 (8%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEE---RKKALDERLR 207
+L++ E A+ ++ +A + KR E+ K++EELR+++E R++ +ER R
Sbjct: 725 QLQQLEKAKAAKLEQERREAEMRAKREEEER-----KRQEELRRQQEEILRRQQEEERKR 779
Query: 208 FEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEE 267
E+E E R++QEE RR RE+E + R +++ + EEA RRL+E+ + R ++E
Sbjct: 780 REEE--ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQE 837
Query: 268 ETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASA 307
E ++K E EEAA + + R + + R+ +A
Sbjct: 838 EL-LRKQE---EEAAKWAREEEEAQRRLEENRLRMEEEAA 873
Score = 50.4 bits (119), Expect = 5e-06
Identities = 42/119 (35%), Positives = 67/119 (56%), Gaps = 25/119 (21%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEEL------------RKEEER 198
R RE+E + Q+ +A ++ RE+ E+ +K+EEL R+EEE
Sbjct: 806 RQREEEERQ------QQEEALRRLEERRREE--EERRKQEELLRKQEEEAAKWAREEEEA 857
Query: 199 KKALDE-RLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQ 256
++ L+E RLR E+E R E+EER+R+ E ++Q E R++QQ +EA RRL++Q
Sbjct: 858 QRRLEENRLRMEEEAARL-RHEEEERKRKELEVQRQKELMRQRQQ---QQEALRRLQQQ 912
Score = 35.8 bits (81), Expect = 0.13
Identities = 36/188 (19%), Positives = 83/188 (44%), Gaps = 40/188 (21%)
Query: 153 REDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEE----RKKALDERLRF 208
+++E A ++ +E R+ E+ + + EEE RK +E R+K L + +
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901
Query: 209 EQERMEQERQEQEER---------------------------------ERRYREREQQIE 235
+QE + + +Q+Q+++ ++ ERE+Q+
Sbjct: 902 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 961
Query: 236 EHRRKQQ--TLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPR 293
E +R+QQ ++A + +++ ++Q + G + + + KS E+++ A Q+ +
Sbjct: 962 EEQRRQQRELMKALQQQQQQQQQKLSG-WGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQ 1020
Query: 294 EFFKQQER 301
+ +Q R
Sbjct: 1021 QQHQQPNR 1028
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 66.2 bits (160), Expect = 9e-11
Identities = 44/142 (30%), Positives = 70/142 (49%), Gaps = 11/142 (7%)
Query: 171 AVEMKRINREQFWEQAKKEEELRK--EEERKKALDERLRFEQERMEQERQEQEERERRYR 228
A+EM+ R+ + K + K EEE+ K ER E+ER E+ER+ + ERERR R
Sbjct: 266 AIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRER 325
Query: 229 EREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDH---------RDEEEETHMKKSESEVE 279
ERE++ E R K++ E E + R ++++ D RD E + K S
Sbjct: 326 EREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSR 385
Query: 280 EAAAIIAQRPDNPREFFKQQER 301
E + + + RE +++ER
Sbjct: 386 EKSRDRERERERERERERERER 407
Score = 51.2 bits (121), Expect = 3e-06
Identities = 50/220 (22%), Positives = 96/220 (43%), Gaps = 38/220 (17%)
Query: 118 VNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRI 177
+NA +E+ I + +S R + L + ++++ + + ++ + E +R
Sbjct: 264 INAIEMEEDKRDLISREISK--FRDTHKKLEEEKGKKEKERQEIEKERRERERERERERE 321
Query: 178 NREQFWEQAK-KEEELRKEEERKKALD---ERLRFEQERMEQERQEQEERER-------- 225
RE+ E+ + +E E KE ER++ D +R + ++ER +RER
Sbjct: 322 RREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDR 381
Query: 226 ---------------RYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETH 270
R RERE++ E R +++ E E + R +E+ D ++EE+ +
Sbjct: 382 SRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAY 441
Query: 271 -MKKSESEVEEAAAIIAQRPDN--------PREFFKQQER 301
+K E ++ E A +R N RE+ K+ ER
Sbjct: 442 ERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAER 481
Score = 47.0 bits (110), Expect = 6e-05
Identities = 29/120 (24%), Positives = 60/120 (50%), Gaps = 4/120 (3%)
Query: 184 EQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERE-RRYREREQQIEEHRRKQQ 242
++++ E+ R E ++ ER R + E+ER+ + ERE R RE++++ + ++
Sbjct: 380 DRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEED 439
Query: 243 TLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERV 302
E + +R+L+E+ R + E +K E E+ A + + RE K+ +R+
Sbjct: 440 AYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEA---EREEERRREMAKEAKRL 496
Score = 46.2 bits (108), Expect = 9e-05
Identities = 32/137 (23%), Positives = 66/137 (48%), Gaps = 7/137 (5%)
Query: 166 QKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERER 225
+ +D + R + + ++E E +E ER++ + E+ER E+ER+ +++++R
Sbjct: 373 RSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERER-EREREREKDKKR 431
Query: 226 RYREREQQIEEHRRKQQTLEAEEA--KRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAA 283
E E+ E R+ ++ L +EA + RLK I R+ ++ +K EE
Sbjct: 432 DREEDEEDAYERRKLERKLREKEAAYQERLKNWEI----RERKKTREYEKEAEREEERRR 487
Query: 284 IIAQRPDNPREFFKQQE 300
+A+ +EF + +
Sbjct: 488 EMAKEAKRLKEFLEDYD 504
Score = 44.3 bits (103), Expect = 4e-04
Identities = 43/181 (23%), Positives = 75/181 (41%), Gaps = 34/181 (18%)
Query: 149 RLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRF 208
R R RE E + + DA E +++ R+ ++A +E L+ E R++
Sbjct: 419 REREREREKDKKRDREEDEEDA-YERRKLERKLREKEAAYQERLKNWEIRERKKTREYEK 477
Query: 209 EQERMEQERQEQEERERRY----------------------------REREQQIEEHRRK 240
E ER E+ R+E + +R RE+E + +E RK
Sbjct: 478 EAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRK 537
Query: 241 QQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQE 300
++ E EE ++RL + H D + E + E+E I Q P++ E ++QE
Sbjct: 538 REKEELEEIRQRLLAEG----HPDPDAELQRMEQEAE-RRRQPQIKQEPESEEEEEEKQE 592
Query: 301 R 301
+
Sbjct: 593 K 593
Score = 43.9 bits (102), Expect = 5e-04
Identities = 34/142 (23%), Positives = 66/142 (46%), Gaps = 5/142 (3%)
Query: 155 DENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERME 214
D N + + + D E +R + + ++E E +E ER++ ER R + ++ +
Sbjct: 376 DRNKDRSRSREKSRDRERERERERERERERERERERERERERERER---EREREKDKKRD 432
Query: 215 QERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGD-HRDEEEETHMKK 273
+E E++ ERR ER+ + E+ Q+ L+ E + R K + + R+EE M K
Sbjct: 433 REEDEEDAYERRKLERKLR-EKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAK 491
Query: 274 SESEVEEAAAIIAQRPDNPREF 295
++E D+P+ +
Sbjct: 492 EAKRLKEFLEDYDDDRDDPKYY 513
Score = 38.5 bits (88), Expect = 0.020
Identities = 39/168 (23%), Positives = 71/168 (42%), Gaps = 36/168 (21%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQ 210
+LRE E A YQ+ E++ + + +E+ + EE R+ E K+A +RL+
Sbjct: 449 KLREKEAA------YQERLKNWEIRERKKTREYEKEAEREEERRREMAKEA--KRLKEFL 500
Query: 211 ERMEQERQEQE-------ERERRYREREQQIEEHRRKQQTLEAEEAKRRL---------- 253
E + +R + + ++ R RE+E + +E RK++ E EE ++RL
Sbjct: 501 EDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDA 560
Query: 254 -----------KEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPD 290
+ Q + EEE K+ + E E + P+
Sbjct: 561 ELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPE 608
Score = 35.4 bits (80), Expect = 0.17
Identities = 27/102 (26%), Positives = 49/102 (48%), Gaps = 1/102 (0%)
Query: 144 SPVLHRLRLREDE-NAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKAL 202
S + RLR RE E A+ +K + +R+ E + + + + +E ER++
Sbjct: 516 SALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQP 575
Query: 203 DERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTL 244
+ E E E+E+QE+EE+ E E++ E+ + TL
Sbjct: 576 QIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTL 617
Score = 31.2 bits (69), Expect = 3.1
Identities = 22/92 (23%), Positives = 48/92 (52%), Gaps = 2/92 (2%)
Query: 215 QERQEQEERERRYRERE-QQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKK 273
++ ++ E E+ +E+E Q+IE+ RR+++ E +RR +E+ + E+E+ ++
Sbjct: 285 RDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERE 344
Query: 274 SESEVEEAAAIIAQRPDNPREFFKQQERVASA 305
E + + R D RE + ++R S+
Sbjct: 345 RERDRDRDRTKERDR-DRDRERDRDRDRERSS 375
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 65.5 bits (158), Expect = 1e-10
Identities = 42/185 (22%), Positives = 91/185 (49%), Gaps = 12/185 (6%)
Query: 166 QKTDAAVEMKRINREQFWEQ--------AKKEEELRKEEERKKALDERLRFEQERMEQER 217
++++A + + +Q EQ A++++ + +++E+++ L+E+ R E+E Q+
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 218 QEQEERERRYREREQQIEEHRRKQQTLE-AEEAKRRLKEQSIFGDHRDEEEETHMKKSES 276
+EQ RE+ + R +++E R++++ AEE KRR++ + + + EEE+ H++ +
Sbjct: 425 REQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQ 484
Query: 277 EVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIP 336
++ + A++ P QQ PS P +H + R P+
Sbjct: 485 QLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSK---PSFHAPEPKAHYEPADRAREVPVR 541
Query: 337 TRSPS 341
T S S
Sbjct: 542 TTSRS 546
Score = 58.2 bits (139), Expect = 2e-08
Identities = 68/257 (26%), Positives = 110/257 (42%), Gaps = 48/257 (18%)
Query: 184 EQAKKEEELRKEEERKKAL--DERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQ 241
+Q +E++LR++EE K+ L + + R EQ++ ++ R E+++R R R+Q+ E+ RR+Q
Sbjct: 373 QQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQ 432
Query: 242 QTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVE-EAAAIIAQRPDNPREFFKQQE 300
E KRRL+E + ++EEE ++ + VE E I Q + R Q+
Sbjct: 433 ------EEKRRLEE--LERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQ 484
Query: 301 RVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDE 360
++ A L HRR P P S P Q ER+
Sbjct: 485 QLLQEQA--------------MLLHDHRR----PHPQHS-------QQPPPPQQERSKPS 519
Query: 361 VTSSQPPPLPPPPPPAQE----TQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGP 416
+ +P P A+E T SP+L +R +P +G +QA R
Sbjct: 520 FHAPEPKAHYEPADRAREVPVRTTSRSPVL----SRRDSPLQGSGQQ----NSQAGQRNS 571
Query: 417 GSPAEDLMFMESAEQAV 433
S E + E E+ V
Sbjct: 572 TSSIEPRLLWERVEKLV 588
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 65.5 bits (158), Expect = 1e-10
Identities = 62/268 (23%), Positives = 121/268 (45%), Gaps = 19/268 (7%)
Query: 175 KRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERE-RRYREREQQ 233
K + +EQ E+ K+ E+ R+ ++ K+ E+ + +Q ME+ER++++E+E R +E+E++
Sbjct: 517 KELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKE 576
Query: 234 IEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPR 293
+++ + +++ E E+ + +L+E+ + R+ E ++K ESE + + P R
Sbjct: 577 LQKMKEQEKECELEKEREKLEEKI---EPREPNLEPMVEKQESE---NSCNKEEEPVFTR 630
Query: 294 EFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQ 353
+ + E+ A+ + S RP L + + +P R +Q
Sbjct: 631 QDSNRSEKEATPVVHETEPESGSQPRPAV-LSGYFKQFQKSLPPRFQRQQEQMKQQQWQQ 689
Query: 354 IER--ALDEVTSSQPPPLPPPPPPAQETQEPSPILDSE------ETRAAAPQAWAGP--M 403
++ L + SQP PPPP + +P + R Q++ P M
Sbjct: 690 QQQQGVLPQTVPSQPSSSTVPPPPHRPLYQPMQPHPQHLASMGFDPRWLMMQSYMDPRMM 749
Query: 404 EEPPQAQAPPRGPGS-PAEDLMFMESAE 430
P PP PG P + LM + E
Sbjct: 750 SGRPAMDIPPIHPGMIPPKPLMRRDQME 777
Score = 40.0 bits (92), Expect = 0.007
Identities = 93/434 (21%), Positives = 150/434 (34%), Gaps = 56/434 (12%)
Query: 211 ERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETH 270
E + +++Q++ + E R ++ EQ I+ +K + +L + +++ T
Sbjct: 1683 EVVSKKQQKRLQDEERRKKEEQVIQVWNKKNANEKGRSQTSKLPPRFA------KKQATG 1736
Query: 271 MKKSESEVEEAAAIIAQRPDN-----PREFFKQQERVASASAGSCDVPSPFNHRPGSHLD 325
+++++S A P + P + S P P +
Sbjct: 1737 IQQAQSSASVPPLASAPLPPSTSASVPASTSAPLPATLTPVPASTSAPVPASTLAPVLAS 1796
Query: 326 SHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPS-- 383
+ + +P+ S S S +AS P + A +SS P P P P P+
Sbjct: 1797 TSAPVPASPLAPVSASASVSASVPASTS---AAAITSSSAPASAPAPTPILASVSTPASV 1853
Query: 384 PILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATA 443
IL S A + P A + P P V+ AP PA+A
Sbjct: 1854 TILASASIPILASALASTSAPTPAPAASSPAAP----------------VITAPTIPASA 1897
Query: 444 DATEIHDAADTIETDTATADTTVANNVP----PAATSLIDLWPGNGEGASTLQGEPRAPT 499
+ A + A A T V+ P PA T P +T Q +
Sbjct: 1898 PTASV-PLAPASASAPAPAPTPVSAPNPAPPAPAQTQAQTHKPVQNPLQTTSQSSKQ--- 1953
Query: 500 PPSGTEVTLAEVPL-LDEVAPEPLL--PAGEGCATLLNFDELPEPPATFCDPEEVEGEPL 556
PP + A+ P D VA + P G T +D PPA D + G P+
Sbjct: 1954 PPPSIRLPSAQTPNGTDYVASGKSIQTPQSHGTLTAELWDNKVAPPAVLNDISKKLG-PI 2012
Query: 557 AAPQTPTLPSALEEL---------EQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEE 607
+ PQ P++ + + L E + + L G T + G AS G E
Sbjct: 2013 SPPQPPSVSAWNKPLTSFGSAPSSEGAKNGQESGLEIGTDTIQFGAPASNG---NENEVV 2069
Query: 608 FAQSEELCAKAPPP 621
SE+ K P P
Sbjct: 2070 PVLSEKSADKIPEP 2083
Score = 37.7 bits (86), Expect = 0.033
Identities = 40/180 (22%), Positives = 65/180 (36%), Gaps = 20/180 (11%)
Query: 271 MKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRM 330
+++ E + ++ I + P + +K + S + N RP RR
Sbjct: 960 IERPEEKPKKEGFIRSSEGPKPEKVYKSKSETRWGPRPSSNRREEVNDRPV------RRS 1013
Query: 331 APT--PIPTRSPSDSSTASTPVAEQIERALDEVT--------SSQPPPLPPPPPPA--QE 378
P P+ + E+ E+ ++V PPP PPP PPA Q
Sbjct: 1014 GPIKKPVLRDMKEEREQRKEKEGEKAEKVTEKVVVKPEKTEKKDLPPPPPPPQPPAPIQP 1073
Query: 379 TQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPV 438
P PI E + A ++P Q P P S + +++ Q +AAPV
Sbjct: 1074 QSVPPPIQPEAEKFPSTETATLA--QKPSQDTEKPLEPVSTVQVEPAVKTVNQQTMAAPV 1131
>gi|239752551 PREDICTED: hypothetical protein [Homo sapiens]
Length = 238
Score = 65.1 bits (157), Expect = 2e-10
Identities = 41/155 (26%), Positives = 84/155 (54%), Gaps = 8/155 (5%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKK---EEELRKEEERKKALDERLR 207
++RE+E E + +K E R E+ WEQ +K +EE E+E K E
Sbjct: 13 KMREEE--EMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKM 70
Query: 208 FEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEE 267
+EQ+R+ +++++ E++ R RE+E+++ E + QQ + E K+ +E+ + + +E+
Sbjct: 71 WEQQRLPEQKEKMWEQDERLREKEERMREQKMWQQVEKMREKKKTQEEKMQEQEEKMQEQ 130
Query: 268 ETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERV 302
E M + E +++E + ++ + RE Q+E++
Sbjct: 131 EEMMWEQEEKMQEQEEKMWEQEEKMRE---QEEKM 162
Score = 53.1 bits (126), Expect = 8e-07
Identities = 32/123 (26%), Positives = 68/123 (55%), Gaps = 7/123 (5%)
Query: 179 REQFWEQAKKEEELRKEEERKKALDERLRFEQERM-EQERQEQEERERRYREREQQIEEH 237
RE+ + ++EE +R++EE+ + +E++R ++E+M EQE + QE+ E+ + + E+ E+
Sbjct: 8 REREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 67
Query: 238 RRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFK 297
+ + E K ++ EQ D R E+E M+ E ++ + + ++ E +
Sbjct: 68 EKMWEQQRLPEQKEKMWEQ----DERLREKEERMR--EQKMWQQVEKMREKKKTQEEKMQ 121
Query: 298 QQE 300
+QE
Sbjct: 122 EQE 124
Score = 52.8 bits (125), Expect = 1e-06
Identities = 37/139 (26%), Positives = 74/139 (53%), Gaps = 12/139 (8%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKAL---DERLR 207
++RE E E + +K E E+ WEQ +K E ++ E+K+ + DERLR
Sbjct: 34 KMREQE--EKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKMWEQDERLR 91
Query: 208 FEQERMEQERQEQE-----ERERRYREREQQIEEHRRKQQTL--EAEEAKRRLKEQSIFG 260
++ERM +++ Q+ E+++ E+ Q+ EE ++Q+ + E EE + +E+
Sbjct: 92 EKEERMREQKMWQQVEKMREKKKTQEEKMQEQEEKMQEQEEMMWEQEEKMQEQEEKMWEQ 151
Query: 261 DHRDEEEETHMKKSESEVE 279
+ + E+E M++ E +++
Sbjct: 152 EEKMREQEEKMREQEEKMQ 170
Score = 50.1 bits (118), Expect = 7e-06
Identities = 27/118 (22%), Positives = 69/118 (58%), Gaps = 6/118 (5%)
Query: 187 KKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRK--QQTL 244
++EE +R+ E++ + +E +R ++E+M+++ ++ E+E + E+E++++E K +Q
Sbjct: 2 REEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEE 61
Query: 245 EAEEAKRRLKEQSIFGDHRDE--EEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQE 300
+ E + ++ EQ + +++ E++ +++ E + E + Q+ + RE K QE
Sbjct: 62 KMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERMREQK--MWQQVEKMREKKKTQE 117
Score = 49.7 bits (117), Expect = 9e-06
Identities = 30/147 (20%), Positives = 86/147 (58%), Gaps = 17/147 (11%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQ 232
E ++ RE+ ++EE+++++EE+ + +E++ ++E+M+++ ++ E+E + E+E+
Sbjct: 9 EREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEE 68
Query: 233 QIEEHRR----KQQTLEAEEAKR----RLKEQSIFGD-----HRDEEEETHMKKSESEVE 279
++ E +R K++ E +E R R++EQ ++ + + +E M++ E +++
Sbjct: 69 KMWEQQRLPEQKEKMWEQDERLREKEERMREQKMWQQVEKMREKKKTQEEKMQEQEEKMQ 128
Query: 280 EAAAIIAQRPDNPRE----FFKQQERV 302
E ++ ++ + +E ++Q+E++
Sbjct: 129 EQEEMMWEQEEKMQEQEEKMWEQEEKM 155
Score = 49.7 bits (117), Expect = 9e-06
Identities = 36/159 (22%), Positives = 84/159 (52%), Gaps = 26/159 (16%)
Query: 149 RLRLREDENAEPVGTTYQKTDAAVEMKRI--NREQFWEQ----AKKEEELRKEE------ 196
+++ +E++ E +++ + E +R+ +E+ WEQ +KEE +R+++
Sbjct: 48 KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERMREQKMWQQVE 107
Query: 197 ---ERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRL 253
E+KK +E+++ ++E+M+++ + E+E + +E+E+++ E K + +E K R
Sbjct: 108 KMREKKKTQEEKMQEQEEKMQEQEEMMWEQEEKMQEQEEKMWEQEEK---MREQEEKMRE 164
Query: 254 KEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNP 292
+E+ + G EE+ ++ + E E + DNP
Sbjct: 165 QEEKMQG---QEEKMRDVEPAGGEAGEGSP-----QDNP 195
Score = 36.6 bits (83), Expect = 0.075
Identities = 23/90 (25%), Positives = 50/90 (55%), Gaps = 5/90 (5%)
Query: 217 RQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIF--GDHRDEEEETHMKKS 274
R+E+ RER + RE++ E R +++ ++ +E K R +E+ ++ + E+EE ++
Sbjct: 2 REEERMREREKKMREEE-EMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQE 60
Query: 275 ESEVEEAAAIIAQR--PDNPREFFKQQERV 302
E E+ + Q+ P+ + ++Q ER+
Sbjct: 61 EKMWEQEEKMWEQQRLPEQKEKMWEQDERL 90
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 65.1 bits (157), Expect = 2e-10
Identities = 59/240 (24%), Positives = 110/240 (45%), Gaps = 34/240 (14%)
Query: 99 ACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRL-------- 150
A S A +++ + ++ +V S E + Q+L L +L + L
Sbjct: 97 ALDSSSAIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGP 156
Query: 151 ----RLREDEN-----AEPVGTTYQKTDAAVE----MKRINREQFWEQAKKEEELRKEEE 197
+L+++ N E VG Q A VE + +NR Q ++EE LR++EE
Sbjct: 157 SKVEQLQDETNHLRKELESVGRQLQ---AEVENNQMLSLLNRRQEERLREQEERLREQEE 213
Query: 198 RKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRK--QQTLEAEEAKRRLKE 255
R + +ERL ++ER+ ++ + E+E R E+E+++ EH + +Q E + RL+E
Sbjct: 214 RLREQEERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLRE 273
Query: 256 QSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPRE----FFKQQERVASASAGSCD 311
Q + R E+E + + E + E + ++ + RE +Q+ER+ C+
Sbjct: 274 Q----EERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCE 329
Score = 55.5 bits (132), Expect = 2e-07
Identities = 43/143 (30%), Positives = 73/143 (51%), Gaps = 6/143 (4%)
Query: 149 RLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRF 208
RLR +E+ E + + E + EQ ++EE L ++EER +ERLR
Sbjct: 235 RLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLRE 294
Query: 209 EQERM---EQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKE-QSIFGDHRD 264
++ER+ E+ +EQEER ER ++ EE +Q+ L +E R L+E + + R
Sbjct: 295 QEERLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQE--RLLEEVEKLLEQERR 352
Query: 265 EEEETHMKKSESEVEEAAAIIAQ 287
+EE+ + + E +EE ++ Q
Sbjct: 353 QEEQERLLERERLLEEVEELLEQ 375
Score = 53.9 bits (128), Expect = 5e-07
Identities = 43/160 (26%), Positives = 76/160 (47%), Gaps = 17/160 (10%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQ 210
RLRE E +++ + E + REQ ++EE LR++EER +ERLR ++
Sbjct: 270 RLREQEER-----LHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQE 324
Query: 211 ERM-EQERQEQEER-----------ERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSI 258
ER+ EQE+ +ER ERR E+E+ +E R ++ E E +R ++
Sbjct: 325 ERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEELLEQERLRQQDER 384
Query: 259 FGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQ 298
+E +++ E +E + ++ PR F++
Sbjct: 385 LWQQETLQELERLRELERMLELGWEALYEQRAEPRSGFEE 424
Score = 51.6 bits (122), Expect = 2e-06
Identities = 40/142 (28%), Positives = 71/142 (50%), Gaps = 14/142 (9%)
Query: 149 RLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRF 208
RLR E+ E ++ + E + EQ ++EE LR++EER +ERLR
Sbjct: 249 RLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLRE 308
Query: 209 EQERM---EQERQEQEER----------ERRYREREQQIEEHRRKQQTLEAEEAKRRLKE 255
++ER+ E+ +EQEER ER E E+ +E+ RR+++ E +R L+E
Sbjct: 309 QEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEE 368
Query: 256 -QSIFGDHRDEEEETHMKKSES 276
+ + R +++ + + E+
Sbjct: 369 VEELLEQERLRQQDERLWQQET 390
Score = 50.8 bits (120), Expect = 4e-06
Identities = 40/146 (27%), Positives = 73/146 (50%), Gaps = 15/146 (10%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKK--EEELR--KEEERKKALDERL 206
RLRE E ++ E R E+ EQ ++ E+E R ++EER +ERL
Sbjct: 200 RLREQE---------ERLREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERL 250
Query: 207 RFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEE 266
R +ER+ ++ + E+E R RE+E+++ H ++++ E EE R +E+ + R E
Sbjct: 251 REHEERLCEQEERLCEQEERLREQEERL--HEQEERLCEQEERLREQEERLCEQEERLRE 308
Query: 267 EETHMKKSESEVEEAAAIIAQRPDNP 292
+E + + E + E + ++ P
Sbjct: 309 QEERLCEQEERLREQEERLCEQEKLP 334
Score = 49.7 bits (117), Expect = 9e-06
Identities = 48/148 (32%), Positives = 74/148 (50%), Gaps = 20/148 (13%)
Query: 149 RLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRF 208
RLR +E+ E ++ + E + REQ EE LR++EER +ERLR
Sbjct: 200 RLREQEERLREQEERLREQEERLCEQEERLREQ-------EERLREQEERLCEQEERLRE 252
Query: 209 EQERM-EQERQ--EQEER--ERRYREREQQ----IEEHRRKQQTLEAEEAKRRLKEQSIF 259
+ER+ EQE + EQEER E+ R EQ+ +E R ++Q E + RL+EQ
Sbjct: 253 HEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQ--- 309
Query: 260 GDHRDEEEETHMKKSESEVEEAAAIIAQ 287
+ R E+E +++ E + E + Q
Sbjct: 310 -EERLCEQEERLREQEERLCEQEKLPGQ 336
Score = 33.9 bits (76), Expect = 0.48
Identities = 43/161 (26%), Positives = 73/161 (45%), Gaps = 23/161 (14%)
Query: 149 RLRLREDENAEPVGTTYQKTDAAVEMKRI-NREQFWEQAKK--EEELRKEE-----ERKK 200
RLR +E+ E ++ + E +++ +E+ E+ +K E+E R+EE ER++
Sbjct: 305 RLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERER 364
Query: 201 ALDE--------RLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRR 252
L+E RLR + ER+ Q+ QE R ER ++ +Q E
Sbjct: 365 LLEEVEELLEQERLRQQDERLWQQETLQELERLRELERMLELGWEALYEQRAEPRSGFEE 424
Query: 253 LKEQSIFGDHRDEEEETHMKKS----ESEVEEAAAIIAQRP 289
L ++ + E++ +KKS E E+AA A RP
Sbjct: 425 LNNEN-KSTLQLEQQVKELKKSGGAEEPRGSESAA--AARP 462
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 65.1 bits (157), Expect = 2e-10
Identities = 110/491 (22%), Positives = 172/491 (35%), Gaps = 106/491 (21%)
Query: 188 KEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAE 247
+E+E E+E++ R + + ++ER + + + R+ + + EE ++ + + E
Sbjct: 919 EEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDE 978
Query: 248 EAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASA 307
E +E D EE K E+EV + E S S+
Sbjct: 979 EDDEEDEEDE------DREEAVDTTKKETEVSDG------------------EDEESDSS 1014
Query: 308 GSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPP 367
C + + + S DS + + + S S SS++S+ +E DE +P
Sbjct: 1015 SKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSE--DEEEEERPA 1072
Query: 368 PLPPPPPPAQETQEPSP----------ILDSEET----RAAAPQAWAGPMEE-PPQA--- 409
LP PP +E P+P + S T + A+P AGP EE PP A
Sbjct: 1073 ALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLR 1132
Query: 410 -QAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTT--- 465
PP GP +PA S+ +L P + + + E AT
Sbjct: 1133 PPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFP 1192
Query: 466 -------------VANNVPPAATSLIDLWP----------GNGEGASTLQGEPRAPTPPS 502
N+P SL+ WP G G T + E
Sbjct: 1193 GPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAE-----P 1247
Query: 503 GTEV---TLAEVPLLDEVAPEPLLPAGEGCATLLNFDEL--------------------- 538
GTEV LA++ L P LPA E DE
Sbjct: 1248 GTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVK 1307
Query: 539 PEPPATFCDPEEVEGEPLA---APQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQA 595
P PPA P E P A +P L + + + +EP+P L + ++EG +
Sbjct: 1308 PTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQL---QQQREEGEEE 1364
Query: 596 SEGYFSQSQEE 606
E + +EE
Sbjct: 1365 GEEEGEEEEEE 1375
Score = 43.9 bits (102), Expect = 5e-04
Identities = 74/354 (20%), Positives = 117/354 (33%), Gaps = 50/354 (14%)
Query: 262 HRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFN---- 317
++D H S + + AI A +S+S+ S S F
Sbjct: 305 YQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDA 364
Query: 318 HRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPP---- 373
+ P + +R T P R + P AE +S PP P P
Sbjct: 365 NYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQD 424
Query: 374 --PPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPA----------- 420
PPA E P P P + P+ +P R GSPA
Sbjct: 425 YRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARS-GSPAPETTNESVPFA 483
Query: 421 ---------EDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVP 471
E L+ + ++ + LA+ E +++ + A DT ++ + P
Sbjct: 484 QHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDT-GSEVPSGSGHGPCTPP 542
Query: 472 PAATSLIDLWP-GNGEGASTLQ-----GEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPA 525
PA + D+ P G+GE +T + G+ +A SG ++ +++ P P P
Sbjct: 543 PAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQ 602
Query: 526 GEGCATLLNFDELPEPPATFCDPEEVEGEPLAAPQTPTLPSALEELEQEQEPEP 579
P PP P + PL P P P+ L + P P
Sbjct: 603 ----------QPPPPPPPPPPPPPYLASLPLGYP--PHQPAYLLPPRPDGPPPP 644
Score = 33.9 bits (76), Expect = 0.48
Identities = 61/273 (22%), Positives = 95/273 (34%), Gaps = 48/273 (17%)
Query: 328 RRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQ------- 380
+R P+ I S STP E + E + +P PP E +
Sbjct: 896 KRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKH 955
Query: 381 EPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEP 440
S LDSE A+ + E+ + + ED E E+AV E
Sbjct: 956 RKSFALDSEGEEASQESSSEKDEEDDEEDE----------ED----EDREEAVDTTKKET 1001
Query: 441 ATADATEIHD--------AADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQ 492
+D + AD+ + +T+D+ +++ +++S + +S
Sbjct: 1002 EVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESS 1061
Query: 493 GE-----------PRAPTPPSGTEVTL---AEVPLLDEVAPEPLLPAGEGCATLLN---- 534
E P A PP V EVP+ + VA P+ P E A+
Sbjct: 1062 SEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGP 1121
Query: 535 FDELPEPPATFCDPEEVEGEPLAAPQTPTLPSA 567
+E P P A PE G P AP+ PS+
Sbjct: 1122 TEESP-PSAPLRPPEPPAGPPAPAPRPDERPSS 1153
Score = 32.0 bits (71), Expect = 1.8
Identities = 41/183 (22%), Positives = 58/183 (31%), Gaps = 18/183 (9%)
Query: 236 EHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHM----KKSESEVEEAAAIIAQRPDN 291
+H +E ++R K + D +EEE + M + + SEV + P
Sbjct: 484 QHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSG---HGPCT 540
Query: 292 PREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPI-PTRSPSDSSTASTPV 350
P E VA +G PG+ +S + P S D +
Sbjct: 541 PPPAPANFEDVAPTGSGE----------PGATRESPKANGQNQASPCSSGDDMEISDDDR 590
Query: 351 AEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQ 410
A PPP PPPPPP P + P+ P E P
Sbjct: 591 GGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPP 650
Query: 411 APP 413
PP
Sbjct: 651 PPP 653
Score = 31.2 bits (69), Expect = 3.1
Identities = 16/36 (44%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 341 SDSSTASTPVAEQIERAL-DEVTSSQPPPLPPPPPP 375
SDSS++S R+L +PPP PPPPPP
Sbjct: 1377 SDSSSSSDGEGALRRRSLRSHARRRRPPPPPPPPPP 1412
>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
Length = 825
Score = 64.7 bits (156), Expect = 3e-10
Identities = 88/382 (23%), Positives = 141/382 (36%), Gaps = 43/382 (11%)
Query: 160 PVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQE 219
P ++ A VE + Q EE +EE R+ L + E E Q
Sbjct: 400 PAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQS 459
Query: 220 QEERERRYREREQQIEEHRRKQQTLEAEEAKRRL---KEQSIFGDHRDEE----EETHMK 272
+E E +I+ + + A+ R +E S H + + EET +
Sbjct: 460 PLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTAE 519
Query: 273 KSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAP 332
++ +E++ AAI A + P E SA +V SP G ++ AP
Sbjct: 520 EASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSP--SAKGVSIEE----AP 573
Query: 333 TPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPP----------PPPAQETQEP 382
+ S +++ A Q+ A + P + PP PPPA+E
Sbjct: 574 LELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAE 633
Query: 383 SPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPAT 442
+EE A + P EE P PP +PAE + AE+A A V+
Sbjct: 634 VQPPPAEE---APAEVQPPPAEEAPAEVQPPPAEEAPAE--VQPPPAEEA--PAEVQSLP 686
Query: 443 ADATEIHDAADTIET----DTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAP 498
A+ T I + + + D + +V + PPA L + +P GE A
Sbjct: 687 AEETPIEETLAAVHSPPADDVPAEEASVDKHSPPADLLLTEEFP---------IGEASAE 737
Query: 499 TPPSGTEVTLAEVPLLDEVAPE 520
P +E T + L++ V+ E
Sbjct: 738 VSPPPSEQTPEDEALVENVSTE 759
Score = 57.8 bits (138), Expect = 3e-08
Identities = 124/555 (22%), Positives = 196/555 (35%), Gaps = 99/555 (17%)
Query: 145 PVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQ--FWEQAKKEEELRKEEERKKAL 202
P + ++L+ D + + T Y ++++++EQ ++ +++ R + K+
Sbjct: 119 PNIPSVQLKMDRSQQTSRTGYWTMMNIPPVEKVDKEQQTYFSESEIVVISRPDSSSTKSK 178
Query: 203 DERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDH 262
++ L+ + + E + E + R T E ++ L E D
Sbjct: 179 EDALKHKSSGKIFASEHPEFQPATNSNEEIGQKNISRTSFTQETKKGPPVLLE-----DE 233
Query: 263 RDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGS 322
EE + + S V++ A+ + P + K Q + + + P P
Sbjct: 234 LREEVTVPVVQEGSAVKKVASAEIEPPSTEKFPAKIQPPLVEEATAKAE-PRPAE----- 287
Query: 323 HLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPP--------- 373
++H ++ P ST TP AE + QPPP P
Sbjct: 288 --ETHVQVQP-----------STEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQ 334
Query: 374 PPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLM---FMESAE 430
PP+ E + PS L +E P A P EEPP PP SP+ +L+ SA+
Sbjct: 335 PPSAE-ESPSVELLAE---ILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQ 390
Query: 431 QAVL--------------AAPVEPATADAT---------EIHDAADTIETDTATADTTVA 467
+A + A VEP T + T E + E +TA T A
Sbjct: 391 KAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETPA 450
Query: 468 NNVPPAATSLIDLWPGNGEGASTLQ----GEPRAPTPPSGTEVTLAEVPLLDEVAPEPLL 523
P S + E ++ +Q EP A P+ L+E +E E
Sbjct: 451 EEAPTEFQSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQS 510
Query: 524 PAGEGCAT--------LLNFDELP--EPPATFCDPEEVEGEPLAAPQTPTLPSA----LE 569
P E LL E P E PA P E AP PSA +E
Sbjct: 511 PLAEETTAEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIE 570
Query: 570 ELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPE 629
E E +P +GE T E A+ + ++ A +EE A+ PP P E
Sbjct: 571 EAPLELQP-----PSGEETTAEEASAAIQLLAATE----ASAEEAPAEVQPPPAEEAPAE 621
Query: 630 IDITCWDADPVPEEE 644
+ P P EE
Sbjct: 622 V-------QPPPAEE 629
Score = 47.8 bits (112), Expect = 3e-05
Identities = 118/526 (22%), Positives = 183/526 (34%), Gaps = 75/526 (14%)
Query: 172 VEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEE--RERRYRE 229
+ K I+R F ++ KK + E+E ++ + + E +++ + E ++
Sbjct: 208 IGQKNISRTSFTQETKKGPPVLLEDELREEVTVPVVQEGSAVKKVASAEIEPPSTEKFPA 267
Query: 230 REQQ--IEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQ 287
+ Q +EE K + AEE ++ Q + D E T + ++ +V+ A A
Sbjct: 268 KIQPPLVEEATAKAEPRPAEET--HVQVQPSTEETPDAEAATAVAENSVKVQPPPAEEAP 325
Query: 288 RPDNPREFFKQQ-------ERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSP 340
+ P E E +A S + SP P L +P+
Sbjct: 326 LVEFPAEIQPPSAEESPSVELLAEILPPSAE-ESPSEEPPAEILPPPAEKSPSVELLGEI 384
Query: 341 SDSSTASTPVAEQ---IERALDEVTSS-QPP----------PLPPPPPPAQETQEPSPIL 386
S P+ Q E AL+E + +PP PL P P +E +E
Sbjct: 385 RSPSAQKAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLST 444
Query: 387 DSEETRAAAPQAWAGPMEEPPQAQ-----------APPRGPGSPAE---DLMFMESAEQA 432
E AP + P+ + A+ P +PAE L SAE+A
Sbjct: 445 AMETPAEEAPTEFQSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEA 504
Query: 433 VLAAPVEPATADATEIHDAADTIE---TDTATADTTVANNVPP------AATSLIDLWPG 483
A V+ A+ T +A+ I+ A AD T A P A + ++
Sbjct: 505 --HAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSP 562
Query: 484 NGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLN--FDELP-- 539
+ +G S ++ P PPSG E T E ++ A E A + +E P
Sbjct: 563 SAKGVS-IEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAE 621
Query: 540 -EPPATFCDPEEVEGEPLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEG 598
+PP P EV+ P P EE E +P P E Q + +
Sbjct: 622 VQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAE-VQPPPAEEAPA 680
Query: 599 YFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEE 644
EE E L A PP AD VP EE
Sbjct: 681 EVQSLPAEETPIEETLAAVHSPP---------------ADDVPAEE 711
>gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo
sapiens]
Length = 693
Score = 64.3 bits (155), Expect = 3e-10
Identities = 58/234 (24%), Positives = 103/234 (44%), Gaps = 21/234 (8%)
Query: 136 SNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKE 195
+ L+ LS RL+ +E+ E ++ + E REQ ++ E LRK+
Sbjct: 325 NQALSLLSKEQKQRLQEQEEMLREQEVQRVREQERLCEQNERLREQQKTLQEQGERLRKQ 384
Query: 196 EERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKE 255
E+R + +ERLR E+ER++++ + ++E R ++E+++++ + + + ++L E
Sbjct: 385 EQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAE 444
Query: 256 -QSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPR-EFFKQQERVASASAGSCDVP 313
Q F D +E KKS ++E+ + ++ D E QQ + +P
Sbjct: 445 PQCSFEDLNNE------KKSALQLEQQVKELQEKLDEEHLEAASQQNQQLETQLSLVALP 498
Query: 314 SPFNHRPGSHLDSHRRMAPTPIP-----------TRSPSDSSTASTPVAEQIER 356
+ G HLDS AP P P T S D EQ+ER
Sbjct: 499 GEGD--GGQHLDSEEEEAPRPTPNIPEDLESREATSSFMDLPKEKADGTEQVER 550
Score = 43.1 bits (100), Expect = 8e-04
Identities = 36/137 (26%), Positives = 74/137 (54%), Gaps = 16/137 (11%)
Query: 180 EQFWEQAKK--------EEELRKEEERKKALDERLRFEQERM-EQERQEQEERERRYRER 230
EQ ++AK E +L+ + E +AL + +++R+ EQE +E+ +R RE+
Sbjct: 298 EQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEVQRVREQ 357
Query: 231 EQQIEEHRR---KQQTLEAEEAKRRLKEQSI-FGDHRDEEEETHMKKSESEVEEAAAIIA 286
E+ E++ R +Q+TL+ + + R +EQ + + R +EE ++K E + + +
Sbjct: 358 ERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLW 417
Query: 287 QRPDNPREFFKQQERVA 303
++ + + KQ+ER+A
Sbjct: 418 KKEERLQ---KQEERLA 431
Score = 32.3 bits (72), Expect = 1.4
Identities = 41/189 (21%), Positives = 73/189 (38%), Gaps = 55/189 (29%)
Query: 193 RKEEERKKALDERLRFEQERMEQERQ-------EQEERERRYREREQQIEEHRRKQQTLE 245
R EE K L RL++ +R+++ + +Q+E +R RE + HRR QQT+
Sbjct: 149 RHFEEESKDLAGRLQYSLQRIQELERALCAVSTQQQEEDRSSSCREAVL--HRRLQQTI- 205
Query: 246 AEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASA 305
KE+++ H + E+ +K+ + E +E A
Sbjct: 206 --------KERALLNAHVTQVTES-LKQVQLERDEYA----------------------- 233
Query: 306 SAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTS-- 363
H G RM + R+ + +++ER+L E+ +
Sbjct: 234 -----------KHIKGERARWQERMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQM 282
Query: 364 SQPPPLPPP 372
++PP L PP
Sbjct: 283 AKPPSLAPP 291
>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo
sapiens]
Length = 693
Score = 63.9 bits (154), Expect = 4e-10
Identities = 57/234 (24%), Positives = 103/234 (44%), Gaps = 21/234 (8%)
Query: 136 SNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKE 195
+ L+ LS RL+ +E+ E ++ + E REQ ++ E LRK+
Sbjct: 325 NQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQ 384
Query: 196 EERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKE 255
E+R + +ERLR E+ER++++ + ++E R ++E+++++ + + + ++L E
Sbjct: 385 EQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAE 444
Query: 256 -QSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPR-EFFKQQERVASASAGSCDVP 313
Q F D +E KKS ++E+ + ++ D E Q+ + +P
Sbjct: 445 PQCSFEDLNNE------KKSALQLEQQVKELQEKLDEEHLEAASQRNQQLETQLSLVALP 498
Query: 314 SPFNHRPGSHLDSHRRMAPTPIP-----------TRSPSDSSTASTPVAEQIER 356
+ G HLDS AP P P T S D EQ+ER
Sbjct: 499 GEGD--GGQHLDSEEEEAPRPTPNIPEDLESREATSSFMDLPKEKADGTEQVER 550
Score = 44.3 bits (103), Expect = 4e-04
Identities = 37/156 (23%), Positives = 82/156 (52%), Gaps = 9/156 (5%)
Query: 154 EDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKK-EEELRKEEERKKALDERLRFEQER 212
+++ AEP + VE + + ++ + E +L+ + E +AL + +++R
Sbjct: 279 KNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQR 338
Query: 213 M-EQERQEQEERERRYREREQQIEEHRR---KQQTLEAEEAKRRLKEQSI-FGDHRDEEE 267
+ EQE +E+ +R RE+E+ E++ R +Q+TL+ + + R +EQ + + R +E
Sbjct: 339 LQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKE 398
Query: 268 ETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVA 303
E ++K E + + + ++ + + KQ+ER+A
Sbjct: 399 EERLQKQEKRLWDQEERLWKKEERLQ---KQEERLA 431
Score = 32.0 bits (71), Expect = 1.8
Identities = 46/235 (19%), Positives = 88/235 (37%), Gaps = 31/235 (13%)
Query: 160 PVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKE-----EERKKALDERLRFEQERME 214
P + YQ+ A+E + Q E + ++ +K+ EE KK +E + + E++E
Sbjct: 66 PGDSQYQELAVALESSSVTINQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMEQLE 125
Query: 215 Q------ERQEQE------ERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDH 262
E+ + + +R R+ E E + R + +E +R L S
Sbjct: 126 TINILTLEKADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQHIQELERALCAVSTQQQE 185
Query: 263 RDEEE---ETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHR 319
D E +++ + + A++ E KQ + A H
Sbjct: 186 EDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYA---------KHI 236
Query: 320 PGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTS--SQPPPLPPP 372
G RM + R+ + +++ER+L E+ + ++PP L PP
Sbjct: 237 KGERARWQERMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPP 291
>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
isoform 1 [Homo sapiens]
Length = 693
Score = 63.9 bits (154), Expect = 4e-10
Identities = 57/234 (24%), Positives = 103/234 (44%), Gaps = 21/234 (8%)
Query: 136 SNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKE 195
+ L+ LS RL+ +E+ E ++ + E REQ ++ E LRK+
Sbjct: 325 NQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQ 384
Query: 196 EERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKE 255
E+R + +ERLR E+ER++++ + ++E R ++E+++++ + + + ++L E
Sbjct: 385 EQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAE 444
Query: 256 -QSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPR-EFFKQQERVASASAGSCDVP 313
Q F D +E KKS ++E+ + ++ D E Q+ + +P
Sbjct: 445 PQCSFEDLNNE------KKSALQLEQQVKELQEKLDEEHLEAASQRNQQLETQLSLVALP 498
Query: 314 SPFNHRPGSHLDSHRRMAPTPIP-----------TRSPSDSSTASTPVAEQIER 356
+ G HLDS AP P P T S D EQ+ER
Sbjct: 499 GEGD--GGQHLDSEEEEAPRPTPNIPEDLESREATSSFMDLPKEKADGTEQVER 550
Score = 44.3 bits (103), Expect = 4e-04
Identities = 37/156 (23%), Positives = 82/156 (52%), Gaps = 9/156 (5%)
Query: 154 EDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKK-EEELRKEEERKKALDERLRFEQER 212
+++ AEP + VE + + ++ + E +L+ + E +AL + +++R
Sbjct: 279 KNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQR 338
Query: 213 M-EQERQEQEERERRYREREQQIEEHRR---KQQTLEAEEAKRRLKEQSI-FGDHRDEEE 267
+ EQE +E+ +R RE+E+ E++ R +Q+TL+ + + R +EQ + + R +E
Sbjct: 339 LQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKE 398
Query: 268 ETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVA 303
E ++K E + + + ++ + + KQ+ER+A
Sbjct: 399 EERLQKQEKRLWDQEERLWKKEERLQ---KQEERLA 431
Score = 33.1 bits (74), Expect = 0.82
Identities = 46/235 (19%), Positives = 88/235 (37%), Gaps = 31/235 (13%)
Query: 160 PVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKE-----EERKKALDERLRFEQERME 214
P + YQ+ A+E + Q E + ++ +K+ EE KK +E + + E++E
Sbjct: 66 PGDSQYQELAVALESSSVTINQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMEQLE 125
Query: 215 Q------ERQEQE------ERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDH 262
E+ + + +R R+ E E + R + +E +R L S
Sbjct: 126 TINILTLEKADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQRIQELERALSAVSTQQQE 185
Query: 263 RDEEE---ETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHR 319
D E +++ + + A++ E KQ + A H
Sbjct: 186 EDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYA---------KHI 236
Query: 320 PGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTS--SQPPPLPPP 372
G RM + R+ + +++ER+L E+ + ++PP L PP
Sbjct: 237 KGERARWQERMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPP 291
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 63.9 bits (154), Expect = 4e-10
Identities = 46/156 (29%), Positives = 80/156 (51%), Gaps = 14/156 (8%)
Query: 150 LRLREDENAEPVGTTYQKTDAAVEMKRINR-------EQFWEQAKKEEELRKE-EERKKA 201
L+L E+E E Q+ E +R R E+ ++ + E++LR+E EER++
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 202 L---DERLRFEQERMEQE-RQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQS 257
L +E R EQER EQ ++EQEER + +RE++ + R K++ + E ++RLK +
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKRE--QEERLEQRLKREE 606
Query: 258 IFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPR 293
+ ++E E +K+ E E E ++ R
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642
Score = 62.0 bits (149), Expect = 2e-09
Identities = 46/155 (29%), Positives = 83/155 (53%), Gaps = 12/155 (7%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQA---KKEEELRKEEERKKALDERLR 207
R +++E E Q+ + + R +E+ EQ ++EEE R+++ R++ +ER
Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374
Query: 208 FEQERMEQERQEQEERERRYREREQQI--EEHRRKQQTLEAEEAKRRLKEQSIFGDHRDE 265
+ R +Q R+EQ+ R + REQQ+ E+ R++Q L E+ RR EQ + R++
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR--EQQL---RREQ 429
Query: 266 EEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQE 300
EEE H +K E E E + + + R++ K++E
Sbjct: 430 EEERHEQKHEQERREQR--LKREQEERRDWLKREE 462
Score = 61.6 bits (148), Expect = 2e-09
Identities = 31/111 (27%), Positives = 69/111 (62%), Gaps = 5/111 (4%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQE-RQEQEER--ERRYRE 229
++ + E+ EQ ++E+ L++E+E ++ D+ L+ E+ER +Q ++EQEER +R RE
Sbjct: 548 QLLKREEEKRLEQERREQRLKREQEERR--DQLLKREEERRQQRLKREQEERLEQRLKRE 605
Query: 230 REQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEE 280
+++E+ R++Q L+ EE + ++Q + + ++E + +++ + E E
Sbjct: 606 EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656
Score = 61.2 bits (147), Expect = 3e-09
Identities = 47/149 (31%), Positives = 73/149 (48%), Gaps = 24/149 (16%)
Query: 173 EMKRINREQFWEQAKKEEE------LRKEEER-----KKALDERLRFEQERMEQERQEQE 221
E KR+ +E+ ++ K+E+E L++EEER K+ +ERL +R E ER EQE
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613
Query: 222 ER-------ERRYREREQQI----EEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETH 270
ER E ER QQ+ E+ R+QQ L E+ +RR EQ + + +E E
Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERR--EQRLKREEEEERLEQR 671
Query: 271 MKKSESEVEEAAAIIAQRPDNPREFFKQQ 299
+K+ E + + + RE K +
Sbjct: 672 LKREHEEERREQELAEEEQEQARERIKSR 700
Score = 60.8 bits (146), Expect = 4e-09
Identities = 39/142 (27%), Positives = 76/142 (53%), Gaps = 12/142 (8%)
Query: 166 QKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERM----EQERQEQE 221
Q+TD ++ E+ Q ++E+ LR++E +K +E LR +++ E++R ++
Sbjct: 1332 QETD-----RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQ 1386
Query: 222 ERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRD---EEEETHMKKSESEV 278
ERER++ + EQQ+ R+QQ + + K R +EQ + RD EEE +++ E E
Sbjct: 1387 ERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERER 1446
Query: 279 EEAAAIIAQRPDNPREFFKQQE 300
+ R + R+F ++++
Sbjct: 1447 KFLEEEQQLRQERHRKFREEEQ 1468
Score = 60.1 bits (144), Expect = 6e-09
Identities = 36/99 (36%), Positives = 60/99 (60%), Gaps = 9/99 (9%)
Query: 184 EQAKKEE--ELRKEEERKKALDERLRFEQE---RMEQERQEQEERERRYREREQQIEEHR 238
EQ +K E ELR+E + ++ +RLR EQ+ + E+ER+EQ+E R +ER +Q EE
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEE-- 333
Query: 239 RKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESE 277
R++Q L E+ +RR EQ + + +E E +++ + E
Sbjct: 334 RREQQLRREQEERR--EQQLRREQEEERREQQLRREQEE 370
Score = 59.7 bits (143), Expect = 8e-09
Identities = 41/154 (26%), Positives = 76/154 (49%), Gaps = 7/154 (4%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQ 210
+ REDE Q + K + E + ++E++LR + +RK +E+L E
Sbjct: 1620 KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEG 1679
Query: 211 ERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETH 270
E + RQE R+R++RE EQQ+ R+++ L+ E+ RR + + F + +ET
Sbjct: 1680 EEQQLRRQE---RDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETE 1736
Query: 271 MKKSESEVEEAAAIIAQ---RPDNPREFFKQQER 301
++ + E I+ + RP+ + ++QER
Sbjct: 1737 QEQLRRQ-ERYRKILEEEQLRPEREEQQLRRQER 1769
Score = 58.2 bits (139), Expect = 2e-08
Identities = 51/172 (29%), Positives = 90/172 (52%), Gaps = 21/172 (12%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEE----ERKKALDERL 206
R +E+E E Q+ +++R + + +Q ++E++LR+E+ E++ +++L
Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 425
Query: 207 RFEQE------RMEQERQEQ----EERERR-YREREQQIEEH---RRKQQTLEAEEAKRR 252
R EQE + EQER+EQ E+ ERR + +RE++ E H RRKQQ +E +RR
Sbjct: 426 RREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR 485
Query: 253 LKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVAS 304
+ + + R E++E ++ E EE QR E + Q+R+ S
Sbjct: 486 ERWLKLEEEERREQQERREQQLRREQEERR---EQRLKRQEEEERLQQRLRS 534
Score = 58.2 bits (139), Expect = 2e-08
Identities = 36/130 (27%), Positives = 74/130 (56%), Gaps = 9/130 (6%)
Query: 178 NREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQ--EERERRYREREQQIE 235
++EQ + ++E+ LR++E +K L E EQ+ QER++Q ++R+R++RE EQQ+
Sbjct: 1369 HQEQGRKFLEEEQRLRRQERERKFLKE----EQQLRCQEREQQLRQDRDRKFREEEQQLS 1424
Query: 236 EHRRKQQTLEAE-EAKRRLKEQSIFGDHRDEEEETHMKKSESE--VEEAAAIIAQRPDNP 292
R ++ E E + +R+ +E+ + + +E H K E E ++E R +
Sbjct: 1425 RQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERD 1484
Query: 293 REFFKQQERV 302
R+F ++++++
Sbjct: 1485 RKFLEEEQQL 1494
Score = 57.8 bits (138), Expect = 3e-08
Identities = 39/140 (27%), Positives = 76/140 (54%), Gaps = 19/140 (13%)
Query: 175 KRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQE--QEERERRYREREQ 232
++ E+ Q ++E+LR++E +K L+E EQ R E+E Q+ ++ER+R++RE EQ
Sbjct: 1723 RKFREEEQLRQETEQEQLRRQERYRKILEE----EQLRPEREEQQLRRQERDRKFREEEQ 1778
Query: 233 QIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEE--------ETHMKKSESEVEEAAAI 284
+E R++Q L ++E+ R+ +E+ R+E++ + ++ + ++EE
Sbjct: 1779 LRQE--REEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQR 1836
Query: 285 IAQRPD---NPREFFKQQER 301
+ Q D E F QE+
Sbjct: 1837 LRQERDRQYRAEEQFATQEK 1856
Score = 57.8 bits (138), Expect = 3e-08
Identities = 38/122 (31%), Positives = 74/122 (60%), Gaps = 14/122 (11%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEE----RKKALDERLRFEQERMEQERQEQ---EERER 225
E +++ ++ + ++EE+LR+E E R + D + R+E+E+++ E QEQ +ER+R
Sbjct: 1784 EEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDR 1843
Query: 226 RYREREQ--QIEEHRRKQQTL--EAEEAKRRLKEQSIFGDH---RDEEEETHMKKSESEV 278
+YR EQ E+ RR++Q L E E+ +R+ +E+ + +H + +EE+ H + E +
Sbjct: 1844 QYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKS 1903
Query: 279 EE 280
+E
Sbjct: 1904 QE 1905
Score = 57.4 bits (137), Expect = 4e-08
Identities = 35/125 (28%), Positives = 64/125 (51%), Gaps = 10/125 (8%)
Query: 179 REQFWEQAKKEEELRKEEE--RKKALDERLRFEQERMEQERQEQEERERRYREREQQIEE 236
R+Q W +EE R+ K AL E+LR EQ+ +++E +E + ER R R++Q +
Sbjct: 870 RDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQ 929
Query: 237 HRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFF 296
+R ++Q + EE R + + R +E E +K + ++ ++ + P+ R
Sbjct: 930 YREEEQLQQEEEQLLREEREK----RRRQERERQYRKDKKLQQKEEQLLGEEPEKRR--- 982
Query: 297 KQQER 301
+QER
Sbjct: 983 -RQER 986
Score = 57.0 bits (136), Expect = 5e-08
Identities = 28/104 (26%), Positives = 61/104 (58%), Gaps = 3/104 (2%)
Query: 172 VEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYRERE 231
+E + + RE+ E+ +++ R+++ R+K +ER ++ER EQ+ + +++ ERR ++
Sbjct: 281 LERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLR 340
Query: 232 QQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSE 275
++ EE R +Q E EE +R EQ + + +E E +++ +
Sbjct: 341 REQEERREQQLRREQEEERR---EQQLRREQEEERREQQLRREQ 381
Score = 56.2 bits (134), Expect = 9e-08
Identities = 47/176 (26%), Positives = 87/176 (49%), Gaps = 12/176 (6%)
Query: 141 RLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKR--INREQFWEQAKKEEELRKEEER 198
RL RL+ +E E K++ E ++ + REQ Q ++E+ L++EEE
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQ---QERREQRLKREEEE 665
Query: 199 KKALDERLR--FEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQ 256
++ L++RL+ E+ER EQE E+E+ + R R + + + + + +A ++K + +
Sbjct: 666 ER-LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPR 724
Query: 257 SIFGDHRDEEEETHMKKSESEV----EEAAAIIAQRPDNPREFFKQQERVASASAG 308
G R +E+E ++ ESE+ EE A Q + R+F Q + + G
Sbjct: 725 KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780
Score = 56.2 bits (134), Expect = 9e-08
Identities = 38/139 (27%), Positives = 77/139 (55%), Gaps = 12/139 (8%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQE-----ERERRY 227
E K + EQ ++E++LR++ +RK +E+ QER + R+E++ ERER++
Sbjct: 1389 ERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKF 1448
Query: 228 REREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDE---EEETHMKKSESEVE-EAAA 283
E EQQ+ + R + + E E+ + +EQ + RD EEE +++ E + +
Sbjct: 1449 LEEEQQLRQERHR-KFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE 1507
Query: 284 IIAQRPDNPREFFKQQERV 302
+ +Q P+ R+F ++++++
Sbjct: 1508 LRSQEPE--RKFLEEEQQL 1524
Score = 55.8 bits (133), Expect = 1e-07
Identities = 38/128 (29%), Positives = 69/128 (53%), Gaps = 12/128 (9%)
Query: 184 EQAKKEEELRKEEE---RKKALDERLRFEQERMEQERQEQEERERRYRE-------REQQ 233
E+ EE+LR+ E R+K +E+ + +ER ++ QE+EE+E R RE + Q
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261
Query: 234 IEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPR 293
EE +R+++ E EE R+L+ Q + + ++EE++ + E ++ +R +
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE--EERREQQE 319
Query: 294 EFFKQQER 301
E +QQER
Sbjct: 320 ERREQQER 327
Score = 55.8 bits (133), Expect = 1e-07
Identities = 43/154 (27%), Positives = 80/154 (51%), Gaps = 6/154 (3%)
Query: 153 REDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQER 212
++ + E +Q+ + KR + E+ +EEE +++ E ++ ++ + E++
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE 285
Query: 213 MEQERQEQEERERRYREREQQI----EEHRRKQQTLEAEEAKRR-LKEQSIFGDHRDEEE 267
+ +ERQE+E++++R R REQQ+ EE RR+QQ E+ +RR +E+ R E+E
Sbjct: 286 LRRERQEEEQQQQRLR-REQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE 344
Query: 268 ETHMKKSESEVEEAAAIIAQRPDNPREFFKQQER 301
E ++ E EE R + E +QQ R
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Score = 55.8 bits (133), Expect = 1e-07
Identities = 40/114 (35%), Positives = 67/114 (58%), Gaps = 11/114 (9%)
Query: 175 KRINREQFWEQAKKEEELRK--EEERKKALDERLRFEQERMEQ--ERQEQEERERRYRER 230
+R EQ ++ ++E++LR+ EEER++ +ER R +QER EQ ER+EQ+ R + R
Sbjct: 289 ERQEEEQQQQRLRREQQLRRKQEEERREQQEER-REQQERREQQEERREQQLRREQEERR 347
Query: 231 EQQI----EEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEE 280
EQQ+ EE RR+QQ +E +RR EQ + + + E+ ++ + E+
Sbjct: 348 EQQLRREQEEERREQQLRREQEEERR--EQQLRREQQLRREQQLRREQQLRREQ 399
Score = 55.8 bits (133), Expect = 1e-07
Identities = 37/138 (26%), Positives = 76/138 (55%), Gaps = 22/138 (15%)
Query: 173 EMKRINREQFWEQAKK----EEELRKEEERK-KALDERLRFEQERMEQERQEQ---EERE 224
E R + W+Q + EE+L +EE+++ K D + + E++ + +ER+E+ +E +
Sbjct: 1276 ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD 1335
Query: 225 RRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAI 284
R++RE EQ ++E R++Q L +E R+ + EEE H ++ +EE +
Sbjct: 1336 RKFREEEQLLQE--REEQPLRRQERDRKFR----------EEELRHQEQGRKFLEEEQRL 1383
Query: 285 IAQRPDNPREFFKQQERV 302
+R + R+F K+++++
Sbjct: 1384 --RRQERERKFLKEEQQL 1399
Score = 55.8 bits (133), Expect = 1e-07
Identities = 37/136 (27%), Positives = 69/136 (50%), Gaps = 18/136 (13%)
Query: 179 REQFWEQAKKEEELRKEEERKKALDER------------LRFEQERMEQER--QEQEERE 224
R Q ++ +E+ELR +E +K L+E L+ EQ+ QER Q +++R+
Sbjct: 1495 RRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554
Query: 225 RRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAI 284
R++RE EQ +E +Q + + + K RL+EQ + R +E+E + E ++
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQERDRKFRLEEQKV----RRQEQERKFMEDEQQLRRQEGQ 1610
Query: 285 IAQRPDNPREFFKQQE 300
R + R+F + ++
Sbjct: 1611 QQLRQERDRKFREDEQ 1626
Score = 55.8 bits (133), Expect = 1e-07
Identities = 39/144 (27%), Positives = 82/144 (56%), Gaps = 16/144 (11%)
Query: 173 EMKRINREQFWEQ-AKKEEELRKEE---ERKKALDERLRFEQERMEQERQEQ----EERE 224
E ++++R+Q + ++E++LR++E +R++ D + R E+E++ QER+EQ +ER+
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFR-EEEQLRQEREEQQLSRQERD 1578
Query: 225 RRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRD----EEEETHMKKSESEV-- 278
R++R EQ++ ++++ +E E+ RR + Q RD E+E+ ++ E ++
Sbjct: 1579 RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR 1638
Query: 279 -EEAAAIIAQRPDNPREFFKQQER 301
E + + P R+ +QQ R
Sbjct: 1639 QERDRKFLEEEPQLRRQEREQQLR 1662
Score = 55.5 bits (132), Expect = 2e-07
Identities = 38/133 (28%), Positives = 67/133 (50%), Gaps = 25/133 (18%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEERK----KALDERLRFEQERMEQERQEQEERERRYR 228
E + EQ EQ ++E+ L++E+E + K +E R EQER +Q+ + +E ERR R
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Query: 229 --------------EREQQI--EEHRRKQQTLEAEEAKRRLK-----EQSIFGDHRDEEE 267
REQQ+ E+ R++Q L+ +E + RL+ EQ + + + E
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547
Query: 268 ETHMKKSESEVEE 280
+ ++ E +E+
Sbjct: 548 QLLKREEEKRLEQ 560
Score = 55.5 bits (132), Expect = 2e-07
Identities = 33/132 (25%), Positives = 71/132 (53%), Gaps = 4/132 (3%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQE--RQEQEERERRYR-- 228
E +R +E+ +Q K+++E + E K +E R +QER EQ+ R+++E RE+R +
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQ 522
Query: 229 EREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQR 288
E E+++++ R +Q L E+ +RR + + R E+E + + E ++ +
Sbjct: 523 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE 582
Query: 289 PDNPREFFKQQE 300
+ ++ K+++
Sbjct: 583 EERRQQRLKREQ 594
Score = 55.1 bits (131), Expect = 2e-07
Identities = 50/175 (28%), Positives = 83/175 (47%), Gaps = 26/175 (14%)
Query: 145 PVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWE-QAKKEEELRKEEER----- 198
P R + RE + E ++ E + R Q WE Q +K++EL++EEE+
Sbjct: 978 PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037
Query: 199 --KKALDERLRFEQERMEQERQEQEER---ERRYREREQQIEEHRRKQ--------QTLE 245
K+ L ER R Q R E+E Q++EE+ E R R Q++E RK+ Q L
Sbjct: 1038 REKRRLQERER--QYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 246 AEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQE 300
E KRR +E+ R EE +++ E ++ +R + R++ +++E
Sbjct: 1096 EEPEKRRRQER-----ERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEE 1145
Score = 55.1 bits (131), Expect = 2e-07
Identities = 34/112 (30%), Positives = 66/112 (58%), Gaps = 7/112 (6%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEER--KKALDERLRFEQERMEQERQEQEERERRYRER 230
E ++ R++ Q ++EEE+++EEE+ ++ ++R R E ER +E +E ++ E +
Sbjct: 1127 EREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLRE 1186
Query: 231 EQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMK-KSESEVEEA 281
EQ+ R++Q E EE +R+ ++Q +RDE++ + +K + E E E A
Sbjct: 1187 EQEKRRQERERQYREEEELQRQKRKQR----YRDEDQRSDLKWQWEPEKENA 1234
Score = 54.7 bits (130), Expect = 3e-07
Identities = 40/156 (25%), Positives = 86/156 (55%), Gaps = 21/156 (13%)
Query: 154 EDENAEPVGTTYQKTDAAVEMKRINR-----EQFWEQAKKEEELRKEEERKKALDERLRF 208
E+E T Y K ++++ + E+ ++ ++E+ R+E+ER+ +E+L+
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ 938
Query: 209 EQE---RMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDE 265
E+E R E+E++ ++ERER+YR +++++++ +++Q L E KRR R E
Sbjct: 939 EEEQLLREEREKRRRQERERQYR-KDKKLQQ--KEEQLLGEEPEKRR----------RQE 985
Query: 266 EEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQER 301
E+ + ++ E + EE + +R R+ +++Q R
Sbjct: 986 REKKYREEEELQQEEEQLLREEREKRRRQEWERQYR 1021
Score = 54.3 bits (129), Expect = 3e-07
Identities = 42/147 (28%), Positives = 71/147 (48%), Gaps = 18/147 (12%)
Query: 133 QRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEEL 192
+R L R +L RE+E + Q+ +KR E+ ++ ++E+ L
Sbjct: 561 ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620
Query: 193 RKEEERKKALDERLRFEQERMEQ--ERQEQEERERRYREREQQIEEHRRKQQTLEAEEAK 250
++EE E+ER +Q + +EQEER ++ REQQ R++Q L+ EE +
Sbjct: 621 KREEP-----------EEERRQQLLKSEEQEERRQQQLRREQQ----ERREQRLKREEEE 665
Query: 251 RRLKEQSIFGDHRDEEEETHMKKSESE 277
RL EQ + +H +E E + + E E
Sbjct: 666 ERL-EQRLKREHEEERREQELAEEEQE 691
Score = 54.3 bits (129), Expect = 3e-07
Identities = 51/173 (29%), Positives = 85/173 (49%), Gaps = 31/173 (17%)
Query: 149 RLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWE-QAKKEEELRKEEE---------R 198
RL+ RE + E ++ E + R Q E Q +KEEEL++EEE R
Sbjct: 1042 RLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKR 1101
Query: 199 KKALDERLRFEQERMEQE-----RQEQEERERRYREREQQIEE--HRRKQQTLEAEEAKR 251
++ ER E+E ++QE R+E+E+R R+ ER+ + EE + ++Q L E KR
Sbjct: 1102 RRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKR 1161
Query: 252 RLKEQSIFGDHRDEE----EETHMKKSESEVEEAAAIIAQRPDNPREFFKQQE 300
R Q + +R+EE EE + + E E +R + R++ +++E
Sbjct: 1162 R--RQELERQYREEEELQQEEEQLLREEQE--------KRRQERERQYREEEE 1204
Score = 53.9 bits (128), Expect = 5e-07
Identities = 37/136 (27%), Positives = 68/136 (50%), Gaps = 13/136 (9%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQ 232
E +R R+ Q K+E+ L +E E+++ + ++ +E Q+ +EQ RE R + R Q
Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014
Query: 233 QIEEHRRKQQTLEAEEA--------KRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAI 284
+ E RK+ L+ EE KRRL+E+ R EE +++ E ++
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQER-----ERQYREEEELQQEEEQLLGEERE 1069
Query: 285 IAQRPDNPREFFKQQE 300
+R + R++ K++E
Sbjct: 1070 TRRRQELERQYRKEEE 1085
Score = 53.5 bits (127), Expect = 6e-07
Identities = 43/169 (25%), Positives = 87/169 (51%), Gaps = 15/169 (8%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERL---R 207
RLR E Q+ +++ +++ + ++E++L ++E +K +E R
Sbjct: 1382 RLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441
Query: 208 FEQER--MEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRL--KEQSIFGDHR 263
E+ER +E+E+Q ++ER R++RE EQ ++E R++Q L +E R+ +EQ + R
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQE--REEQQLHRQERDRKFLEEEQQLRRQER 1499
Query: 264 DEE-EETHMKKSESE---VEEAAAIIAQRPDNPREFFKQQERVASASAG 308
D + E ++ E E +EE + R R+F ++++++ G
Sbjct: 1500 DRKFREQELRSQEPERKFLEEEQQL--HRQQRQRKFLQEEQQLRRQERG 1546
Score = 52.8 bits (125), Expect = 1e-06
Identities = 38/137 (27%), Positives = 70/137 (51%), Gaps = 17/137 (12%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQF----WEQAKKEEELRKEEERKKAL---- 202
R +E+E E QK + +R+ REQ W + ++E E ++E RK+ L
Sbjct: 427 REQEEERHE------QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQ 480
Query: 203 --DERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFG 260
+ R R+ + E+ R++QE RE++ R +++ E R K+Q E E ++RL+ +
Sbjct: 481 EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE-EEERLQQRLRSEQQLR 539
Query: 261 DHRDEEEETHMKKSESE 277
++E E +K+ E +
Sbjct: 540 REQEERREQLLKREEEK 556
Score = 52.8 bits (125), Expect = 1e-06
Identities = 43/146 (29%), Positives = 76/146 (52%), Gaps = 33/146 (22%)
Query: 173 EMKRINREQFWEQAKKEEEL----------RKEEERKKALDERLRFEQERM---EQERQE 219
E +R RE+ EQ ++EEE R+E ER+ D++L+ ++E++ E E++
Sbjct: 925 EQERQYREE--EQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982
Query: 220 QEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVE 279
++ERE++YRE E+ +E ++Q L E KRR R E E + KK E + E
Sbjct: 983 RQEREKKYREEEELQQE---EEQLLREEREKRR----------RQEWERQYRKKDELQQE 1029
Query: 280 EAAAIIAQR-----PDNPREFFKQQE 300
E + +R + R++ +++E
Sbjct: 1030 EEQLLREEREKRRLQERERQYREEEE 1055
Score = 52.8 bits (125), Expect = 1e-06
Identities = 37/124 (29%), Positives = 68/124 (54%), Gaps = 19/124 (15%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEE----------RKKALDERLRFEQERMEQE----RQ 218
E ++ R++ Q ++EEEL++EEE R++ L+ + R E+E ++E R+
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156
Query: 219 EQEERERRYREREQQIEE--HRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSES 276
E E+R R+ ER+ + EE + ++Q L E+ KRR + + +R+EEE K+ +
Sbjct: 1157 EPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER---QYREEEELQRQKRKQR 1213
Query: 277 EVEE 280
+E
Sbjct: 1214 YRDE 1217
Score = 52.4 bits (124), Expect = 1e-06
Identities = 51/147 (34%), Positives = 83/147 (56%), Gaps = 24/147 (16%)
Query: 173 EMKRINREQFWEQ-AKKEEELRKEEERKKALDERLRFEQE-RMEQ--ERQEQEER-ERRY 227
++KR E+ E+ K EEE R+E++ ++ +++LR EQE R EQ +RQE+EER ++R
Sbjct: 475 QLKRDQEEERRERWLKLEEEERREQQERR--EQQLRREQEERREQRLKRQEEEERLQQRL 532
Query: 228 REREQ-QIEEHRRKQQTLEAEEAKR--------RLKEQSIFGDHRDE----EEETHMKKS 274
R +Q + E+ R++Q L+ EE KR RLK + + RD+ EEE ++
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQ--EERRDQLLKREEERRQQRL 590
Query: 275 ESEVEEAAAIIAQRPDNPREFFKQQER 301
+ E EE +R + R +Q+ER
Sbjct: 591 KREQEERLEQRLKREEVER--LEQEER 615
Score = 52.4 bits (124), Expect = 1e-06
Identities = 32/128 (25%), Positives = 67/128 (52%), Gaps = 8/128 (6%)
Query: 179 REQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHR 238
R Q ++ +EEE ++E ++ L + R + R+E+++ ++E+ER++ E EQQ+
Sbjct: 1549 RRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQE 1608
Query: 239 RKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQ------RPDNP 292
+QQ + + K R EQ + R+E++ ++ +EE + Q R D
Sbjct: 1609 GQQQLRQERDRKFREDEQLL--QEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRD 1666
Query: 293 REFFKQQE 300
R+F ++++
Sbjct: 1667 RKFREEEQ 1674
Score = 52.0 bits (123), Expect = 2e-06
Identities = 37/138 (26%), Positives = 78/138 (56%), Gaps = 17/138 (12%)
Query: 175 KRINREQFWEQAKKEEELRKEEERKK--------ALDERLRFEQERMEQ--ERQEQEERE 224
+++ REQ Q ++E++LR+E+E ++ ++RL+ EQE +R+E+ ER
Sbjct: 411 QQLRREQ---QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERH 467
Query: 225 RRYREREQ--QIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAA 282
+ R ++Q + +E R+++ L+ EE +RR +++ R E+EE ++ + + EE
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEER 527
Query: 283 AIIAQRPDNPREFFKQQE 300
+ QR + ++ ++QE
Sbjct: 528 --LQQRLRSEQQLRREQE 543
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/126 (24%), Positives = 68/126 (53%), Gaps = 7/126 (5%)
Query: 180 EQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQ---EERERRYREREQQIEE 236
EQ ++ ++++ R+E +RK +E+ QER + R+++ +E ER++ E EQQ+
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR 1526
Query: 237 HRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFF 296
+R+++ L+ E+ RR + G R ++ + ++ E +E R + R+F
Sbjct: 1527 QQRQRKFLQEEQQLRRQER----GQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFR 1582
Query: 297 KQQERV 302
++++V
Sbjct: 1583 LEEQKV 1588
Score = 51.2 bits (121), Expect = 3e-06
Identities = 38/114 (33%), Positives = 64/114 (56%), Gaps = 10/114 (8%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQE-----RMEQERQ-EQEERERR 226
E K + EQ + + +++LR+E +RK DE+L E+E R E++R+ +EE + R
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653
Query: 227 YREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRD---EEEETHMKKSESE 277
+EREQQ+ H R ++ E E+ + +EQ + RD EEE +++ E E
Sbjct: 1654 RQEREQQL-RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE 1706
Score = 51.2 bits (121), Expect = 3e-06
Identities = 35/116 (30%), Positives = 64/116 (55%), Gaps = 12/116 (10%)
Query: 173 EMKRINREQFWEQAKKEEELRKEE-ERKKALDERLRFEQERMEQERQEQ-----EERERR 226
+++R RE+ + Q +E++LR++E ERK +E+LR E E+ + RQE+ EE + R
Sbjct: 1699 QLRRQERERKFLQ--EEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLR 1756
Query: 227 YREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRD----EEEETHMKKSESEV 278
EQQ+ R ++ E E+ ++ +EQ + D EEE+ ++ E ++
Sbjct: 1757 PEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQL 1812
Score = 50.8 bits (120), Expect = 4e-06
Identities = 35/143 (24%), Positives = 76/143 (53%), Gaps = 11/143 (7%)
Query: 166 QKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERER 225
Q+ + E++ + E+ ++ ++ ++L++EE+ + ER R +++R +Q+ + Q E ER
Sbjct: 823 QRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEER 882
Query: 226 RYRER----EQQIEEHRRKQQTL---EAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEV 278
+ R + ++E RK+Q L E EE +R +E+ R E+E + ++ + +
Sbjct: 883 KRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKR----RRQEQERQYREEEQLQQ 938
Query: 279 EEAAAIIAQRPDNPREFFKQQER 301
EE + +R R+ ++Q R
Sbjct: 939 EEEQLLREEREKRRRQERERQYR 961
Score = 50.8 bits (120), Expect = 4e-06
Identities = 38/131 (29%), Positives = 74/131 (56%), Gaps = 12/131 (9%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQ 232
E KR +R+ E+ EE R+E+ R++ D + R E+E++ QER+EQ R R+ R+R+
Sbjct: 1306 EAKRRDRKSQEEKQLLREE-REEKRRRQETDRKFR-EEEQLLQEREEQPLR-RQERDRKF 1362
Query: 233 QIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNP 292
+ EE R ++Q + E ++RL+ Q EE++ ++ E ++ R D
Sbjct: 1363 REEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQL---------RQDRD 1413
Query: 293 REFFKQQERVA 303
R+F +++++++
Sbjct: 1414 RKFREEEQQLS 1424
Score = 50.8 bits (120), Expect = 4e-06
Identities = 37/139 (26%), Positives = 74/139 (53%), Gaps = 18/139 (12%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEERKKAL----DERLRFEQERME-QERQEQEERERRY 227
E +R+ R++ + KEE+ + +ER++ L D + R E++++ Q ER+R++
Sbjct: 1379 EEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQ------ERDRKF 1432
Query: 228 REREQQIEEHRRKQQTLEAE-----EAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAA 282
RE EQQ+ R+++ LE E E R+ +E+ R+E++ ++ +EE
Sbjct: 1433 REEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQ 1492
Query: 283 AIIAQRPDNPREFFKQQER 301
+ +R + R+F +Q+ R
Sbjct: 1493 QL--RRQERDRKFREQELR 1509
Score = 50.8 bits (120), Expect = 4e-06
Identities = 33/124 (26%), Positives = 70/124 (56%), Gaps = 16/124 (12%)
Query: 187 KKEEELRKEEERKKALDERLRF---EQERMEQERQ-EQEERERRYREREQQIEEHRRKQQ 242
++E++LR++E +K ++ LR E++ +E+E+Q +++R+R++ + EQQ+ R QQ
Sbjct: 1489 EEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQ 1548
Query: 243 TLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESE----VEEAAAIIAQRPDNPREFFKQ 298
+ + K R +EQ R E EE + + E + +EE +R + R+F +
Sbjct: 1549 RRQDRDRKFREEEQL-----RQEREEQQLSRQERDRKFRLEEQK---VRRQEQERKFMED 1600
Query: 299 QERV 302
++++
Sbjct: 1601 EQQL 1604
Score = 50.4 bits (119), Expect = 5e-06
Identities = 36/150 (24%), Positives = 80/150 (53%), Gaps = 22/150 (14%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEERKKALD--------ERLRFEQERMEQERQE--QEE 222
E++R RE+ Q ++E+ LR+E E+++ + E L+ E+E++ +E QE ++E
Sbjct: 1135 ELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQE 1194
Query: 223 RERRYREREQQIEEHRRKQQTLEAE-----------EAKRRLKEQSIFGDHRDEEEETHM 271
RER+YRE E++++ +RKQ+ + + E + +++ ++ R+ E+ +
Sbjct: 1195 RERQYRE-EEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL 1253
Query: 272 KKSESEVEEAAAIIAQRPDNPREFFKQQER 301
+ S+ ++ + +E ++QER
Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQQERDREQER 1283
Score = 50.4 bits (119), Expect = 5e-06
Identities = 29/110 (26%), Positives = 60/110 (54%), Gaps = 8/110 (7%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQ 232
+++R R++ + + +E++LR++E +K L E + R E ER+ +EE + R ++
Sbjct: 1683 QLRRQERDRKFRE--EEQQLRRQERERKFLQEEQQLR--RQELERKFREEEQLRQETEQE 1738
Query: 233 QIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRD----EEEETHMKKSESEV 278
Q+ R ++ LE E+ + +EQ + RD EEE+ ++ E ++
Sbjct: 1739 QLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQL 1788
Score = 50.4 bits (119), Expect = 5e-06
Identities = 34/130 (26%), Positives = 73/130 (56%), Gaps = 4/130 (3%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQ 232
E +++ R++ + ++EE+LR+E E ++ + + EQ RQE+EE++ R ++R+
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRD- 1818
Query: 233 QIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNP 292
++R +++ L+ EE ++RL+++ +R EE+ +KS E +E Q+
Sbjct: 1819 --GKYRWEEEQLQLEEQEQRLRQER-DRQYRAEEQFATQEKSRREEQELWQEEEQKRRQE 1875
Query: 293 REFFKQQERV 302
RE ++E +
Sbjct: 1876 RERKLREEHI 1885
Score = 50.1 bits (118), Expect = 7e-06
Identities = 40/153 (26%), Positives = 73/153 (47%), Gaps = 40/153 (26%)
Query: 184 EQAKKEEELRKEEERKKALDERLRFEQERMEQ------------ERQEQEERERRYRERE 231
E ++ + R+E+ER+ A E +QER+EQ +RQE +ERE R E E
Sbjct: 132 EPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEE 191
Query: 232 Q------------QIEEHRRKQQTL-------EAEEAKRRLKEQSIFGDHRDEE---EET 269
Q EE R+++ L E ++ +RR ++ +F + ++E ET
Sbjct: 192 QLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRET 251
Query: 270 HMKKSESEVEEAAAIIAQRPDNPREFFKQQERV 302
++K E +++E + P RE +++E++
Sbjct: 252 VLRKEEEKLQE------EEPQRQRELQEEEEQL 278
Score = 49.7 bits (117), Expect = 9e-06
Identities = 39/144 (27%), Positives = 77/144 (53%), Gaps = 27/144 (18%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEER--KKALDERLRFEQER-------MEQERQE--QE 221
E ++ R++ ++ ++EEEL++EEE+ ++ ++R R E ER ++QE ++ +E
Sbjct: 977 EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE 1036
Query: 222 ERE-RRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRD----EEEETHMKKSES 276
ERE RR +ERE+Q E QQ +E+ + G+ R+ +E E +K E
Sbjct: 1037 EREKRRLQERERQYREEEELQQ-----------EEEQLLGEERETRRRQELERQYRKEEE 1085
Query: 277 EVEEAAAIIAQRPDNPREFFKQQE 300
+E ++ + P+ R ++++
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERERQ 1109
Score = 49.7 bits (117), Expect = 9e-06
Identities = 36/132 (27%), Positives = 64/132 (48%), Gaps = 10/132 (7%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQ 210
+ RE+E G Q + K EQ + ++E + +EE++ + + +F +
Sbjct: 1668 KFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFRE 1727
Query: 211 ERMEQERQEQEERERRYREREQQIEEH-----RRKQQTLEAEEAKRRLKEQSIFGDHRDE 265
E EQ RQE E+ + R +ER ++I E R++Q L +E R+ +E+ R E
Sbjct: 1728 E--EQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEE---QLRQE 1782
Query: 266 EEETHMKKSESE 277
EE ++ ES+
Sbjct: 1783 REEQQLRSQESD 1794
Score = 48.9 bits (115), Expect = 1e-05
Identities = 37/148 (25%), Positives = 80/148 (54%), Gaps = 24/148 (16%)
Query: 173 EMKRINREQFWEQAKKEEE-LRKEEERKKALDERLRFEQERMEQERQE----QE------ 221
E ++++R++ + ++EE+ +R++E +K L+E + QER + R+E QE
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQL 1478
Query: 222 ---ERERRYREREQQIEEHRR----KQQTLEAEEAKRRL--KEQSIFGDHRDEEEETHMK 272
ER+R++ E EQQ+ R ++Q L ++E +R+ +EQ + HR + + ++
Sbjct: 1479 HRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL---HRQQRQRKFLQ 1535
Query: 273 KSESEVEEAAAIIAQRPDNPREFFKQQE 300
+ E ++ +R D R+F ++++
Sbjct: 1536 E-EQQLRRQERGQQRRQDRDRKFREEEQ 1562
Score = 48.1 bits (113), Expect = 2e-05
Identities = 39/163 (23%), Positives = 84/163 (51%), Gaps = 19/163 (11%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKK----EEELRKEEERKKALDERL 206
+LR++ + + + +E +++ R+ EQ +K E++LR++E +++ ER
Sbjct: 1562 QLRQEREEQQLSRQERDRKFRLEEQKVRRQ---EQERKFMEDEQQLRRQEGQQQLRQERD 1618
Query: 207 RFEQERMEQERQEQE-------ERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIF 259
R +E EQ QE+E ER+R++ E E Q+ R+QQ + K R +EQ +
Sbjct: 1619 RKFRED-EQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLL- 1676
Query: 260 GDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERV 302
EE++ ++ + + E + +R + R+F ++++++
Sbjct: 1677 --QEGEEQQLRRQERDRKFREEEQQL-RRQERERKFLQEEQQL 1716
Score = 47.8 bits (112), Expect = 3e-05
Identities = 38/179 (21%), Positives = 85/179 (47%), Gaps = 13/179 (7%)
Query: 133 QRLSNGLARLSSPVLHRLRLREDENA---EPVGTTYQKTDAAVEMKRINRE-QFWEQAKK 188
+RL L R L E+E E + + K +E + R+ + + + +K
Sbjct: 666 ERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRK 725
Query: 189 EEELRK---EEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLE 245
+E R+ +EE+++ + L++++E +Q++EE+ R + + Q E+ R +Q L
Sbjct: 726 QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLS 785
Query: 246 AEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPRE--FFKQQERV 302
A R +E+ + + R + E+ + + E + + QR + +E F +++E++
Sbjct: 786 ARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR----RQRREREKELQFLEEEEQL 840
Score = 47.0 bits (110), Expect = 6e-05
Identities = 36/129 (27%), Positives = 66/129 (51%), Gaps = 13/129 (10%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQE-----RMEQE-RQEQEE--RE 224
E +R+ + Q ++EEEL++EEE+ + R QE R E+E +QE+E+ RE
Sbjct: 1039 EKRRLQERE--RQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096
Query: 225 RRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAI 284
+ R Q+ E R+++ L+ EE + +E+ R +E E ++ E +E +
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREERE---KRRRQELERQYREEEEVQQEEEQL 1153
Query: 285 IAQRPDNPR 293
+ + P+ R
Sbjct: 1154 LREEPEKRR 1162
Score = 45.8 bits (107), Expect = 1e-04
Identities = 28/96 (29%), Positives = 55/96 (57%), Gaps = 10/96 (10%)
Query: 187 KKEEELRKEEERKKALDERLRFEQERMEQERQEQEERER--RYREREQQIEEHRRKQQTL 244
++E +LR EE +++ ++R E+E EQ R+++ ERE+ ++ E E+Q++ R QQ
Sbjct: 793 QRERQLRAEERQQR--EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850
Query: 245 EAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEE 280
E E+ + +E+ R +E+ +K ++EE
Sbjct: 851 EEEDGLQEDQER------RRSQEQRRDQKWRWQLEE 880
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/109 (28%), Positives = 57/109 (52%), Gaps = 12/109 (11%)
Query: 179 REQFWEQAKKEEELRKEEERKKALDER--LRFEQERMEQERQ-----EQEERERRYRERE 231
+E + ++EE+ R+ E R + L+E R Q+R EQER+ EQ E++ R +R+
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD 165
Query: 232 QQIEEH---RRKQQTLEAEEAKRRLKEQSIFGDHRDEE--EETHMKKSE 275
+Q + R++Q+ E EE + ++ H EE +E +++ E
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Score = 44.3 bits (103), Expect = 4e-04
Identities = 30/116 (25%), Positives = 61/116 (52%), Gaps = 8/116 (6%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEERKKALDERLRFE-QERMEQERQE-------QEERE 224
E KR RE + ++E R+++E ++ D +++ +E+ E+ RQ +E+RE
Sbjct: 736 EEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE 795
Query: 225 RRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEE 280
R+ R E+Q E R + E E+ +R+ +E+ +EEE+ ++ +++E
Sbjct: 796 RQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851
Score = 43.1 bits (100), Expect = 8e-04
Identities = 40/147 (27%), Positives = 72/147 (48%), Gaps = 20/147 (13%)
Query: 175 KRINREQFW--EQAKKEEELRKEEERKKAL---DERLRFEQERMEQERQEQE----ERER 225
+R REQ + E+ +KE+ R+ ER+K L +E + ++ Q+ QE+E E +
Sbjct: 802 ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE 861
Query: 226 RYREREQ--------QIEEHR-RKQQTLEAEEA--KRRLKEQSIFGDHRDEEEETHMKKS 274
R R +EQ Q+EE R R++ TL A+ A ++ KEQ + + +E + +K
Sbjct: 862 RRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKR 921
Query: 275 ESEVEEAAAIIAQRPDNPREFFKQQER 301
+ +E ++ E ++ER
Sbjct: 922 RRQEQERQYREEEQLQQEEEQLLREER 948
Score = 43.1 bits (100), Expect = 8e-04
Identities = 34/95 (35%), Positives = 51/95 (53%), Gaps = 12/95 (12%)
Query: 188 KEEELRKEEERKKALDERLR--------FEQERMEQERQE--QEERERRYREREQQI-EE 236
+EE+L+ EE+ ++ ER R QE+ +E QE QEE ++R +ERE+++ EE
Sbjct: 1824 EEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREE 1883
Query: 237 HRRKQQTLEAEEAK-RRLKEQSIFGDHRDEEEETH 270
H R+QQ E + +K Q G R E TH
Sbjct: 1884 HIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTH 1918
Score = 42.7 bits (99), Expect = 0.001
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 28/177 (15%)
Query: 148 HRLRLREDENAEPVGTTYQKTDAAV-EMKRINREQFWEQAKKEEELRKEEERKKALDERL 206
H L +++ + E +Q+ D E +++ RE EQ + + RK +E K+ L E
Sbjct: 1269 HLLGEQQERDREQERRRWQQRDRHFPEEEQLERE---EQKEAKRRDRKSQEEKQLLREER 1325
Query: 207 RFEQERMEQER----QEQE------------ERERRYREREQQIEEHRRK----QQTLEA 246
++ R E +R +EQ ER+R++RE E + +E RK +Q L
Sbjct: 1326 EEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRR 1385
Query: 247 EEAKRR-LKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERV 302
+E +R+ LKE+ R +E E +++ R + R+F +++++V
Sbjct: 1386 QERERKFLKEEQ---QLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQV 1439
Score = 41.2 bits (95), Expect = 0.003
Identities = 29/83 (34%), Positives = 48/83 (57%), Gaps = 10/83 (12%)
Query: 179 REQFWEQAKKEEELRKE-----EERKKALDERLRFEQERMEQERQEQEERERRYREREQQ 233
REQ Q + EE ++E EE +K R R E+E+ Q +E+E+ +R RER QQ
Sbjct: 791 REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR--RERAQQ 848
Query: 234 IEEHRRKQQTLEAEEAKRRLKEQ 256
++E ++ L+ ++ +RR +EQ
Sbjct: 849 LQE---EEDGLQEDQERRRSQEQ 868
Score = 40.0 bits (92), Expect = 0.007
Identities = 27/106 (25%), Positives = 58/106 (54%), Gaps = 6/106 (5%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQ 210
+LR++ + + + E +++ E+ ++ ++E + + E + A E+ R E+
Sbjct: 1802 QLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE 1861
Query: 211 ERMEQERQEQ--EERERRYRE---REQQIEEHRRKQ-QTLEAEEAK 250
+ + QE +++ +ERER+ RE R QQ EE R +Q ++++E K
Sbjct: 1862 QELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGK 1907
Score = 38.1 bits (87), Expect = 0.026
Identities = 41/169 (24%), Positives = 79/169 (46%), Gaps = 23/169 (13%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQ 210
R R+ E + +K E +R + + WE K+ + K +E+ R +
Sbjct: 1195 RERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLE 1254
Query: 211 ERMEQERQEQE-------ERERRYRERE----QQIEEHRRKQQTLEAE---EAKRR---- 252
+ ++RQ Q+ E++ R RE+E QQ + H +++ LE E EAKRR
Sbjct: 1255 DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKS 1314
Query: 253 LKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQER 301
+E+ + + R EE+ ++++ + E ++ +R + P ++QER
Sbjct: 1315 QEEKQLLREER--EEKRRRQETDRKFREEEQLLQEREEQP---LRRQER 1358
Score = 36.6 bits (83), Expect = 0.075
Identities = 24/82 (29%), Positives = 46/82 (56%), Gaps = 8/82 (9%)
Query: 202 LDERLRFE---QERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSI 258
LDE R +E + Q+R+ QEE +RR+ R++Q+EE +++ + +E +R L E
Sbjct: 95 LDEEKRARCDGKESLLQDRR-QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE--- 150
Query: 259 FGDHRDEEEETHMKKSESEVEE 280
G+ + E++E ++ +E
Sbjct: 151 -GEEQSEKQERLEQRDRQRRDE 171
Score = 35.0 bits (79), Expect = 0.22
Identities = 27/99 (27%), Positives = 48/99 (48%), Gaps = 19/99 (19%)
Query: 195 EEERKKALDERLRFEQERMEQERQ----------EQEERERRYREREQQI------EEHR 238
+EE++ D + Q+R ++E Q E+E +RR ++R++Q EE
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 239 RKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESE 277
KQ+ LE + +RR +E R E +E +++E E
Sbjct: 156 EKQERLEQRDRQRRDEE---LWRQRQEWQEREERRAEEE 191
Score = 33.9 bits (76), Expect = 0.48
Identities = 20/88 (22%), Positives = 42/88 (47%), Gaps = 2/88 (2%)
Query: 195 EEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLK 254
EE+R + + + R E++++ E R+R+ E Q +R++Q E E + + +
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 255 EQSIF--GDHRDEEEETHMKKSESEVEE 280
+Q D + +EE ++ E + E
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQERE 184
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 63.5 bits (153), Expect = 6e-10
Identities = 40/174 (22%), Positives = 89/174 (51%), Gaps = 18/174 (10%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKK----EEELRKEEERKKALDERL 206
++RE+E + +++ E K +E+ W Q +K EE++RK+EE+ +E++
Sbjct: 512 KIREEEKRQEQEEMWRQ-----EEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKM 566
Query: 207 RFEQERMEQERQEQEERERRYREREQQIEEHRRK-----QQTLEAEEAKRRLKEQSIFGD 261
++E++ ++ ++ +E + RE+E++I E K + T E EE +E+ +
Sbjct: 567 HDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQE 626
Query: 262 HRDEEEETHMKKSESEVEEAAAIIAQRPDNPRE----FFKQQERVASASAGSCD 311
+ +E+E M++ E ++ E I ++ + RE +Q+E++ C+
Sbjct: 627 EKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCE 680
Score = 58.5 bits (140), Expect = 2e-08
Identities = 42/157 (26%), Positives = 78/157 (49%), Gaps = 13/157 (8%)
Query: 156 ENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERM-- 213
E E + +K E R E WE KEE++R++EE +E++R ++E M
Sbjct: 379 EQEEKIREQEEKIREQEEKMRRQEEMMWE---KEEKMRRQEEMMWEKEEKMRRQEEMMWE 435
Query: 214 ------EQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSI-FGDHRDEE 266
E E + E+ + R +E ++Q EE R+Q+ + +EAK +E+ I + + E
Sbjct: 436 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 495
Query: 267 EETHMKKSESEVEEAAAI-IAQRPDNPREFFKQQERV 302
+E M + E ++ E I ++ E ++Q+E++
Sbjct: 496 QEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI 532
Score = 57.8 bits (138), Expect = 3e-08
Identities = 32/133 (24%), Positives = 77/133 (57%), Gaps = 2/133 (1%)
Query: 149 RLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRF 208
++R +E++ E T ++ + E + EQ + ++EE++R++EE+ + ++++R
Sbjct: 593 KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE 652
Query: 209 EQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEE 268
++E++ ++ + +E+E + E+E+++ E K Q E EE RR +E+ + R ++E
Sbjct: 653 QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ--EQEEKMRRQEEKMWEQEVRLRQQE 710
Query: 269 THMKKSESEVEEA 281
M++ + +E A
Sbjct: 711 EKMQEHQEHLEAA 723
Score = 56.2 bits (134), Expect = 9e-08
Identities = 47/163 (28%), Positives = 86/163 (52%), Gaps = 16/163 (9%)
Query: 149 RLRLREDENAEPVGTTYQKTDAAVE----MKRINREQFWEQAKKEEELRKEEERKKALDE 204
+L+ D + + + K A VE R+N++Q + ++EE++++ EE+ + +E
Sbjct: 323 QLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEE 382
Query: 205 RLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTL--EAEEAKRRLKEQSIFGDH 262
++R ++E++ +EQEE+ RR E + EE R+Q+ + E EE RR +E +
Sbjct: 383 KIREQEEKI----REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 438
Query: 263 --RDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVA 303
R+ EE+ H ++ E EE Q + RE K+QE+ A
Sbjct: 439 KIRELEEKMHEQEKIREQEEK----RQEEEKIREQEKRQEQEA 477
Score = 56.2 bits (134), Expect = 9e-08
Identities = 46/189 (24%), Positives = 102/189 (53%), Gaps = 21/189 (11%)
Query: 127 DAGAIGQRLSNGLARLSSPV-----LHRLRLREDENAEPVGTTYQKTDAAV-EMKRINRE 180
+A +G+ L + A+L + V +RL +++E Q+ + + E + RE
Sbjct: 327 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 386
Query: 181 QFWEQAKKEEELRKEEERKKALDERLRFEQERM----EQERQEQE---ERERRYREREQQ 233
Q + ++EE++R++EE +E++R ++E M E+ R+++E E+E + RE E++
Sbjct: 387 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 446
Query: 234 IEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPR 293
+ E Q+ + +E KR+ +E+ I + +E+E M + E ++ E I ++ +
Sbjct: 447 MHE----QEKIREQEEKRQ-EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEE--- 498
Query: 294 EFFKQQERV 302
+ ++Q+E++
Sbjct: 499 KMWRQEEKI 507
Score = 55.8 bits (133), Expect = 1e-07
Identities = 39/136 (28%), Positives = 76/136 (55%), Gaps = 10/136 (7%)
Query: 173 EMKRINREQFWEQAKK----EEELRKEEERKKALDERLRFEQE--RMEQERQEQEERERR 226
E ++ + W Q +K EE++R++EE+ +E++ EQE R E++RQEQEE R+
Sbjct: 470 EKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIH-EQEKIREEEKRQEQEEMWRQ 528
Query: 227 YREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIA 286
+ +Q E R+K++ E EE R+ +E+ + + ++E +++ E +V I
Sbjct: 529 EEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIR 588
Query: 287 QRPDNPREFFKQQERV 302
++ + RE Q+E++
Sbjct: 589 EQEEKIRE---QEEKI 601
Score = 55.8 bits (133), Expect = 1e-07
Identities = 42/155 (27%), Positives = 84/155 (54%), Gaps = 15/155 (9%)
Query: 151 RLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQ 210
++R+ E E + +K E R E+ W Q EE++R++EE+ + +E++R EQ
Sbjct: 551 KIRKQE--EKMWRQEEKMHDQEEKIREQEEKVWRQ---EEKIREQEEKIREQEEKIR-EQ 604
Query: 211 ERMEQERQ----EQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEE 266
E M QE++ EQEE+ E+ Q+ EE R+Q+ + E +++++EQ + + E
Sbjct: 605 EEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEE-KIREQEKKIREQ----EEKIRE 659
Query: 267 EETHMKKSESEVEEAAAIIAQRPDNPREFFKQQER 301
+E M++ E ++ E + ++ + +E ++ R
Sbjct: 660 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR 694
Score = 53.9 bits (128), Expect = 5e-07
Identities = 43/161 (26%), Positives = 82/161 (50%), Gaps = 14/161 (8%)
Query: 153 REDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQER 212
+E++ E +++ + E + REQ E+ +++EE+ +E+E K E EQE
Sbjct: 569 QEEKIREQEEKVWRQEEKIREQEEKIREQE-EKIREQEEMTQEQEEKMGEQEEKMCEQEE 627
Query: 213 MEQE------RQEQE--ERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRD 264
QE RQE++ E+E++ RE+E++I E Q E EE +E+ + +
Sbjct: 628 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ--EQEEKMWEQEEKMCEQEEKM 685
Query: 265 EEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASA 305
+E+E M++ E ++ E + Q+ + +E QE + +A
Sbjct: 686 QEQEEKMRRQEEKMWEQEVRLRQQEEKMQE---HQEHLEAA 723
Score = 52.4 bits (124), Expect = 1e-06
Identities = 34/131 (25%), Positives = 69/131 (52%), Gaps = 10/131 (7%)
Query: 173 EMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQER-QEQEERERRYRERE 231
E R E WE KEE++R+ EE+ ++ E++R E+E+ +EQE+R+ + +
Sbjct: 424 EKMRRQEEMMWE---KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 480
Query: 232 QQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDN 291
+Q E+ R +++ + +E K +E+ I + EEE ++ E +E ++
Sbjct: 481 RQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE------EKIRE 534
Query: 292 PREFFKQQERV 302
E ++Q+E++
Sbjct: 535 QEEIWRQKEKI 545
Score = 50.4 bits (119), Expect = 5e-06
Identities = 34/135 (25%), Positives = 74/135 (54%), Gaps = 8/135 (5%)
Query: 173 EMKRINREQFWEQAKK--EEELRKEEERKKALDERLRFEQERMEQE---RQEQEERERRY 227
E R E+ W Q +K E+E +EEE+++ +E R E++ EQE RQ+++ E+
Sbjct: 491 EKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEE 550
Query: 228 REREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQ 287
+ R+Q+ + R++++ + EE R +E+ + + E+E +++ E ++ E + +
Sbjct: 551 KIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQE 610
Query: 288 RPDNPREFFKQQERV 302
+ + E Q+E++
Sbjct: 611 QEEKMGE---QEEKM 622
Score = 34.7 bits (78), Expect = 0.28
Identities = 31/136 (22%), Positives = 65/136 (47%), Gaps = 11/136 (8%)
Query: 170 AAVEMKRINREQFWEQAKKEEE-LRKEEERKKALDERLRFEQERMEQERQEQEERERRYR 228
+AV ++ +++ E+ KE + L E R DE L+ + +++++ Q E +
Sbjct: 243 SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKS--- 299
Query: 229 EREQQIEEHRRKQQTLEAEEAKRRLKEQSIFG--DHRDEEEETHMKKSESEVEEAAAIIA 286
E + ++E +RK E AK L +Q + DH +E ++ K +++VEE
Sbjct: 300 EIQLNVKELKRK-----LERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 354
Query: 287 QRPDNPREFFKQQERV 302
+ ++Q+E++
Sbjct: 355 LNQQQEEKMWRQEEKI 370
Score = 32.7 bits (73), Expect = 1.1
Identities = 35/145 (24%), Positives = 70/145 (48%), Gaps = 6/145 (4%)
Query: 139 LARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEER 198
L ++ + +L+L E E +E + ++ +E ++ Q QA+ + L KE +
Sbjct: 280 LKEKNAKLQEKLQLVESEKSE-IQLNVKELKRKLERAKLLLPQQQLQAEADH-LGKELQS 337
Query: 199 KKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSI 258
A + E E + Q+QEE+ R E+ Q+ EE ++Q+ + E + +++EQ
Sbjct: 338 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEE-KIREQEEKIREQEE 396
Query: 259 FGDHRDE---EEETHMKKSESEVEE 280
++E E+E M++ E + E
Sbjct: 397 KMRRQEEMMWEKEEKMRRQEEMMWE 421
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 63.5 bits (153), Expect = 6e-10
Identities = 65/255 (25%), Positives = 98/255 (38%), Gaps = 40/255 (15%)
Query: 180 EQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRR 239
E+ E+ ++EEE +EEE ++ +E E+E E+E +E+EE E + E E ++EE
Sbjct: 888 EEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEE 947
Query: 240 KQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRP---DNPREFF 296
++ E EE +E E+ + EVEE A P P
Sbjct: 948 EEDEEEEEEL--------------EEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPP 993
Query: 297 KQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSST---ASTPVAEQ 353
K Q +V PG+ + APT P PS +P A
Sbjct: 994 KVQPEPEPEPGLLLEV-----EEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGP 1048
Query: 354 IERALDEVTSSQPPPL-------------PPPPPPAQETQEPSPILDS--EETRAAAPQA 398
+ L E S PP L PPP PA+E E ++ E+ +
Sbjct: 1049 PPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAM 1108
Query: 399 WAGPMEEPPQAQAPP 413
A ++ PP + PP
Sbjct: 1109 LADFIDCPPDDEKPP 1123
Score = 50.4 bits (119), Expect = 5e-06
Identities = 61/237 (25%), Positives = 95/237 (40%), Gaps = 16/237 (6%)
Query: 201 ALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFG 260
AL+E L E +E+EE E E E++ EE +++ E E + +E+ F
Sbjct: 873 ALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFE 932
Query: 261 DHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRP 320
+ +EEE ++ E E EE + + D EF V + +P P P
Sbjct: 933 EEFEEEEGELEEEEEEEDEEEEEELEEVED--LEFGTAGGEVEEGAPPPPTLP-PALPPP 989
Query: 321 GSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQ 380
+S ++ P P P P P E+ ER D + P LP +E +
Sbjct: 990 ----ESPPKVQPEPEP--EPGLLLEVEEPGTEE-ERGADTAPTLAPEALPSQGEVEREGE 1042
Query: 381 EPS----PILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAV 433
P+ P EE +A P E+ PP P +PAE+ M E+ +A+
Sbjct: 1043 SPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPP--PETPAEEEMETETEAEAL 1097
Score = 48.1 bits (113), Expect = 2e-05
Identities = 37/129 (28%), Positives = 47/129 (36%), Gaps = 24/129 (18%)
Query: 312 VPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTP--------------VAEQIERA 357
+P P NHR GS+ D + TP PT P ++ P V +E
Sbjct: 724 LPGPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESD 783
Query: 358 LDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAP----------QAWAGPMEEPP 407
D+ P LPP PPP P PI + A+ P A GP+ PP
Sbjct: 784 SDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPP 843
Query: 408 QAQAPPRGP 416
P GP
Sbjct: 844 PPPPPVPGP 852
Score = 45.4 bits (106), Expect = 2e-04
Identities = 81/302 (26%), Positives = 102/302 (33%), Gaps = 61/302 (20%)
Query: 362 TSSQPPPLPPPPPP----AQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPG 417
T P P+PPP P A P P+ +A P AGPM P P PG
Sbjct: 644 TCPTPAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPSAGPM--PSAGPVPSARPG 701
Query: 418 SPAEDLMFMESAEQAVLAAP----VEPATADATEIHDAADTIE---------TDTATADT 464
P +A L+ P V P E H A + T D
Sbjct: 702 PPT-------TANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIPPDE 754
Query: 465 TVANNVP-PA--------ATSLIDLWPGNGEGASTLQGE---PRAPTPPSG--------T 504
T VP PA A+ + + + + + E P P PPSG T
Sbjct: 755 TFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPT 814
Query: 505 EVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEP-PATFCDPEEV-EGEPLAAPQTP 562
A P+ + PE LPA G P P P T P+ V EG P P
Sbjct: 815 GPPTASPPVPAKEEPEE-LPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTP-GGGGPP 872
Query: 563 TLPSAL-----------EELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQS 611
L L EE E+E+E E E +E + E YF + +EEE
Sbjct: 873 ALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFE 932
Query: 612 EE 613
EE
Sbjct: 933 EE 934
Score = 45.1 bits (105), Expect = 2e-04
Identities = 74/323 (22%), Positives = 103/323 (31%), Gaps = 43/323 (13%)
Query: 336 PTRSPSDSSTASTPV-AEQIERALDEVTSSQPPPLPPPPP-PAQETQEPSPILDSEETRA 393
P +P+ TAS PV A++ L PPP PPPPP P T P ++
Sbjct: 809 PPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGG 868
Query: 394 AAPQAWAGPM------------EEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPA 441
P A + EE + + ED E E+ E
Sbjct: 869 GGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEE 928
Query: 442 TADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPP 501
E + +E + D + + DL G G +G P PT P
Sbjct: 929 EEFEEEFEEEEGELEEEEEEEDEEEEEEL----EEVEDLEFGTA-GGEVEEGAPPPPTLP 983
Query: 502 SGTEVTLAEVPLLDEVAPEPLL-----------PAGEGCATLLNFDELP---------EP 541
+ + E PEP L G A L + LP E
Sbjct: 984 PALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGES 1043
Query: 542 PATFCDPEEVEGEPLAAPQTPTLPSALEELEQEQEPEPHLLTNGE---TTQKEGTQASEG 598
PA P+E+ E +AP T L E+ + +P P E T+ E Q E
Sbjct: 1044 PAAGPPPQELVEEEPSAPPT-LLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQ 1102
Query: 599 YFSQSQEEEFAQSEELCAKAPPP 621
+ + +F K PPP
Sbjct: 1103 DDTAAMLADFIDCPPDDEKPPPP 1125
>gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo
sapiens]
Length = 693
Score = 63.5 bits (153), Expect = 6e-10
Identities = 57/234 (24%), Positives = 102/234 (43%), Gaps = 21/234 (8%)
Query: 136 SNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKE 195
+ L+ LS RL+ +E+ E ++ + E REQ ++ E LRK+
Sbjct: 325 NQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQ 384
Query: 196 EERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKE 255
E+R + +ERLR E+ER++++ + ++E R ++E+++++ + + + ++L E
Sbjct: 385 EQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAE 444
Query: 256 -QSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPR-EFFKQQERVASASAGSCDVP 313
Q F D +E KKS ++E+ + ++ D E Q + +P
Sbjct: 445 PQCSFEDLNNE------KKSALQLEQQVKELQEKLDEEHLEAASHQNQQLETQLSLVALP 498
Query: 314 SPFNHRPGSHLDSHRRMAPTPIP-----------TRSPSDSSTASTPVAEQIER 356
+ G HLDS AP P P T S D EQ+ER
Sbjct: 499 GEGD--GGQHLDSEEEEAPRPTPNIPEDLESREATSSFMDLPKEKADGTEQVER 550
Score = 44.3 bits (103), Expect = 4e-04
Identities = 37/156 (23%), Positives = 82/156 (52%), Gaps = 9/156 (5%)
Query: 154 EDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKK-EEELRKEEERKKALDERLRFEQER 212
+++ AEP + VE + + ++ + E +L+ + E +AL + +++R
Sbjct: 279 KNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQR 338
Query: 213 M-EQERQEQEERERRYREREQQIEEHRR---KQQTLEAEEAKRRLKEQSI-FGDHRDEEE 267
+ EQE +E+ +R RE+E+ E++ R +Q+TL+ + + R +EQ + + R +E
Sbjct: 339 LQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKE 398
Query: 268 ETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVA 303
E ++K E + + + ++ + + KQ+ER+A
Sbjct: 399 EERLQKQEKRLWDQEERLWKKEERLQ---KQEERLA 431
Score = 32.7 bits (73), Expect = 1.1
Identities = 47/235 (20%), Positives = 88/235 (37%), Gaps = 31/235 (13%)
Query: 160 PVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKE-----EERKKALDERLRFEQERME 214
P + YQ+ A+E + Q E + ++ +K+ EE KK +E + + ER+E
Sbjct: 66 PGDSQYQELAVALESSSVTISQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMERLE 125
Query: 215 Q------ERQEQE------ERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDH 262
E+ + + +R R+ E E + R + +E +R L S
Sbjct: 126 TINILTLEKADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQRIQELERALCAVSTQQQE 185
Query: 263 RDEEE---ETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHR 319
D E +++ + + A++ E KQ + A H
Sbjct: 186 EDRSSSCREAVLQRWLQQTIKERALLNAHVTQVTESLKQVQLERDEYA---------KHI 236
Query: 320 PGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTS--SQPPPLPPP 372
G RM + R+ + +++ER+L E+ + ++PP L PP
Sbjct: 237 KGERARWQERMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPP 291
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.127 0.368
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,151,333
Number of Sequences: 37866
Number of extensions: 2057163
Number of successful extensions: 54959
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1145
Number of HSP's successfully gapped in prelim test: 1999
Number of HSP's that attempted gapping in prelim test: 15979
Number of HSP's gapped (non-prelim): 17905
length of query: 651
length of database: 18,247,518
effective HSP length: 109
effective length of query: 542
effective length of database: 14,120,124
effective search space: 7653107208
effective search space used: 7653107208
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.