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Search of human proteins with 18250298
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo sapiens]
(488 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 1008 0.0
gi|4503787 fyn-related kinase [Homo sapiens] 378 e-105
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 367 e-101
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 367 e-101
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 367 e-101
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 367 e-101
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 359 3e-99
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 359 3e-99
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 359 3e-99
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 355 7e-98
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 354 1e-97
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 354 1e-97
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 354 1e-97
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 350 2e-96
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 348 5e-96
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 348 5e-96
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 347 1e-95
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 312 4e-85
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 312 4e-85
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 307 2e-83
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 305 6e-83
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 305 6e-83
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 305 6e-83
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 305 6e-83
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 305 6e-83
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 278 8e-75
gi|148596974 TXK tyrosine kinase [Homo sapiens] 276 3e-74
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 273 3e-73
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 269 4e-72
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 259 3e-69
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 1008 bits (2605), Expect = 0.0
Identities = 488/488 (100%), Positives = 488/488 (100%)
Query: 1 MEPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALY 60
MEPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALY
Sbjct: 1 MEPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALY 60
Query: 61 DFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPW 120
DFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPW
Sbjct: 61 DFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPW 120
Query: 121 YFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLY 180
YFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLY
Sbjct: 121 YFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLY 180
Query: 181 LQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSEFALGRKLGEGY 240
LQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSEFALGRKLGEGY
Sbjct: 181 LQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSEFALGRKLGEGY 240
Query: 241 FGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYI 300
FGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYI
Sbjct: 241 FGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYI 300
Query: 301 VTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDD 360
VTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDD
Sbjct: 301 VTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDD 360
Query: 361 GLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVF 420
GLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVF
Sbjct: 361 GLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVF 420
Query: 421 TYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480
TYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL
Sbjct: 421 TYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480
Query: 481 HAIHRCHP 488
HAIHRCHP
Sbjct: 481 HAIHRCHP 488
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 378 bits (970), Expect = e-105
Identities = 204/458 (44%), Positives = 278/458 (60%), Gaps = 24/458 (5%)
Query: 45 PAEPCSPFPQ----LFLALYDFTARCGGELSVRRGDRLCALEE-GGGYIFARRL------ 93
P CSP Q F+AL+D+ AR +LS R GD+L L+ G+ FAR L
Sbjct: 32 PGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDG 91
Query: 94 SGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSL 153
S Q G +P +VA+ +L +PW+F + R+ A++ LL N+ G+FLIR SES
Sbjct: 92 SSQQLQGYIPSNYVAE--DRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQK 149
Query: 154 GGYSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCM 213
G +SLSV A V HYR+ +G +L + R+F L E +++Y + L +PC+
Sbjct: 150 GEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCL 209
Query: 214 PQKAPRQ--------DVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANM 265
+ P D WE + L ++LG G FGEVWEGLW + PVA+K +K +M
Sbjct: 210 KIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSM 269
Query: 266 KLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLP 325
D +E Q +K LRH +LI+L+AVC+ +P+YI+TELMR G+LQ +L G + L
Sbjct: 270 DPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLT 329
Query: 326 PLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLK---DDIYSP 382
+ A QVA GM+YLE + +HRDLAARNVLV + KVADFGLAR+ K +DIY
Sbjct: 330 QQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYES 389
Query: 383 SSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRG 442
K+PVKWTAPEA FS KSDVWSFG+LL+E+ TYG+ PY GMT + +Q + +
Sbjct: 390 RHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQN 449
Query: 443 YRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480
YRLP+P+ CP + Y +MLECW + P+ERP+F TLR KL
Sbjct: 450 YRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKL 487
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 367 bits (943), Expect = e-101
Identities = 204/432 (47%), Positives = 263/432 (60%), Gaps = 10/432 (2%)
Query: 56 FLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLS---GQPSAGLVPITHVAKASP 112
++ L+DF +R ELS R GD + + +A L G + G VP ++A+
Sbjct: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAER-- 70
Query: 113 ETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVS 172
ET+ +PW+F +SR++A + L + N GAFLIR SE Y LSVR V HY++
Sbjct: 71 ETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIW 130
Query: 173 MAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCM---PQKAPRQDVWERPHSE 229
A G L+L + F L EL+ Y++A L PC P+ P D WERP E
Sbjct: 131 RRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREE 190
Query: 230 FALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTD-LAKEIQTLKGLRHERLIRL 288
F L RKLG GYFGEV+EGLW + VAIKVI N+ L EIQ +K LRH+ ++ L
Sbjct: 191 FTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILAL 250
Query: 289 HAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVH 348
+AV S G+PVYI+TELM KG+L L + + L + LL A QVAEGM YLE Q +H
Sbjct: 251 YAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIH 310
Query: 349 RDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSD 408
RDLAARN+LV + CKV DFGLARL+K+D+Y S IP KWTAPEA + +S KSD
Sbjct: 311 RDLAARNILVGENTLCKVGDFGLARLIKEDVYL-SHDHNIPYKWTAPEALSRGHYSTKSD 369
Query: 409 VWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPE 468
VWSFG+LLHE+F+ GQ PY GM+NHE ++ GYR+P P CP V+ LML CW PE
Sbjct: 370 VWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPE 429
Query: 469 ERPSFATLREKL 480
+RP F LRE+L
Sbjct: 430 QRPCFKALRERL 441
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 367 bits (941), Expect = e-101
Identities = 201/454 (44%), Positives = 278/454 (61%), Gaps = 17/454 (3%)
Query: 39 DPVPTLPAE--PCSPFPQ-LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLS- 94
DP+ T P SP L +AL+ + G+L +G++L LE+ G + A+ L+
Sbjct: 46 DPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTT 105
Query: 95 GQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLG 154
GQ G +P VAKA+ +L +PW+F +SR A++ LL+P N G+FLIR SES+ G
Sbjct: 106 GQE--GFIPFNFVAKAN--SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAG 161
Query: 155 GYSLSVRA----QAKVC-HYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLL 209
+SLSVR Q +V HY++ +G Y+ FPGL EL+ +Y + L
Sbjct: 162 SFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLS 221
Query: 210 QPCMPQKAPR---QDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMK 266
+PC QK + +D WE P L +LG G FGEVW G + G VA+K +K +M
Sbjct: 222 RPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMS 281
Query: 267 LTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPP 326
E +K L+H+RL+RL+AV + EP+YI+TE M G+L FL TP G L +
Sbjct: 282 PDAFLAEANLMKQLQHQRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSGIKLTINK 340
Query: 327 LLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSS 386
LL A Q+AEGM+++EE+ +HRDL A N+LV D L+CK+ADFGLARL++D+ Y+ +
Sbjct: 341 LLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGA 400
Query: 387 KIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLP 446
K P+KWTAPEA NY F+ KSDVWSFG+LL E+ T+G+ PY GMTN E +Q + RGYR+
Sbjct: 401 KFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV 460
Query: 447 RPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480
RP CP E+Y LM CW+ PE+RP+F LR L
Sbjct: 461 RPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVL 494
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 367 bits (941), Expect = e-101
Identities = 201/454 (44%), Positives = 278/454 (61%), Gaps = 17/454 (3%)
Query: 39 DPVPTLPAE--PCSPFPQ-LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLS- 94
DP+ T P SP L +AL+ + G+L +G++L LE+ G + A+ L+
Sbjct: 46 DPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTT 105
Query: 95 GQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLG 154
GQ G +P VAKA+ +L +PW+F +SR A++ LL+P N G+FLIR SES+ G
Sbjct: 106 GQE--GFIPFNFVAKAN--SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAG 161
Query: 155 GYSLSVRA----QAKVC-HYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLL 209
+SLSVR Q +V HY++ +G Y+ FPGL EL+ +Y + L
Sbjct: 162 SFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLS 221
Query: 210 QPCMPQKAPR---QDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMK 266
+PC QK + +D WE P L +LG G FGEVW G + G VA+K +K +M
Sbjct: 222 RPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMS 281
Query: 267 LTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPP 326
E +K L+H+RL+RL+AV + EP+YI+TE M G+L FL TP G L +
Sbjct: 282 PDAFLAEANLMKQLQHQRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSGIKLTINK 340
Query: 327 LLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSS 386
LL A Q+AEGM+++EE+ +HRDL A N+LV D L+CK+ADFGLARL++D+ Y+ +
Sbjct: 341 LLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGA 400
Query: 387 KIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLP 446
K P+KWTAPEA NY F+ KSDVWSFG+LL E+ T+G+ PY GMTN E +Q + RGYR+
Sbjct: 401 KFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV 460
Query: 447 RPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480
RP CP E+Y LM CW+ PE+RP+F LR L
Sbjct: 461 RPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVL 494
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 367 bits (941), Expect = e-101
Identities = 191/458 (41%), Positives = 282/458 (61%), Gaps = 17/458 (3%)
Query: 31 PGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFA 90
P S + NT + +E + +ALYD+ A +LS ++GD++ LEE G + A
Sbjct: 63 PNSHNSNTPGIREAGSEDI-----IVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKA 117
Query: 91 RRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSE 150
R L+ + G +P +VA+ ++L + W+F G+SR A++ LL+P N G+F+IR SE
Sbjct: 118 RSLATRKE-GYIPSNYVARV--DSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSE 174
Query: 151 SSLGGYSLSVRAQAK-----VCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQ 205
++ G YSLSVR V HY++ +G Y+ F L+EL+ +YK +
Sbjct: 175 TTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLC 234
Query: 206 NPLLQPCM---PQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKS 262
L PCM PQK +D WE P L +KLG G FGEVW + VA+K +K
Sbjct: 235 QKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKP 294
Query: 263 ANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRAL 322
+M + E +K L+H++L++LHAV + EP+YI+TE M KG+L FL + EG
Sbjct: 295 GSMSVEAFLAEANVMKTLQHDKLVKLHAVVTK-EPIYIITEFMAKGSLLDFLKSDEGSKQ 353
Query: 323 RLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSP 382
LP L+ F+ Q+AEGM+++E++ +HRDL A N+LV L CK+ADFGLAR+++D+ Y+
Sbjct: 354 PLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTA 413
Query: 383 SSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRG 442
+K P+KWTAPEA N+ F+ KSDVWSFG+LL E+ TYG+ PY GM+N E ++ + RG
Sbjct: 414 REGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERG 473
Query: 443 YRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480
YR+PRP CP E+Y +M+ CW++ PEERP+F ++ L
Sbjct: 474 YRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVL 511
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 359 bits (922), Expect = 3e-99
Identities = 193/435 (44%), Positives = 261/435 (60%), Gaps = 12/435 (2%)
Query: 55 LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPET 114
LF+ALYD+ AR +L+ +G++ L G + R G +P +VA ++
Sbjct: 81 LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV--DS 138
Query: 115 LSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAK-----VCHY 169
+ + WYF + R A++ LLSP N GAFLIR SE++ G YSLS+R + V HY
Sbjct: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHY 198
Query: 170 RVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPR----QDVWER 225
++ G Y+ F ++EL+ +Y + N L+ PC K +D WE
Sbjct: 199 KIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEI 258
Query: 226 PHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERL 285
S L R+LG G FG+VW G W GS VA+K +K M +E Q +K LRH++L
Sbjct: 259 SRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKL 318
Query: 286 IRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQR 345
++L+AV S EP+YIVTE M G+L FL PEG+ LRLP L+ A QVAEGM+Y+E
Sbjct: 319 VQLYAVVSE-EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMN 377
Query: 346 VVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQ 405
+HRDL A N+LV + LACK+ADFGLARL+KDD Y+P SK P+KWTAPEAA + F+
Sbjct: 378 YIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTI 437
Query: 406 KSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRS 465
KSDVWSFG+LL E+ T G+ PY GM E L+Q+ +GY +P P CPA +Y M + WR
Sbjct: 438 KSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRL 497
Query: 466 SPEERPSFATLREKL 480
PEERP+F L+ L
Sbjct: 498 DPEERPTFEYLQSFL 512
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 359 bits (922), Expect = 3e-99
Identities = 193/435 (44%), Positives = 261/435 (60%), Gaps = 12/435 (2%)
Query: 55 LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPET 114
LF+ALYD+ AR +L+ +G++ L G + R G +P +VA ++
Sbjct: 81 LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV--DS 138
Query: 115 LSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAK-----VCHY 169
+ + WYF + R A++ LLSP N GAFLIR SE++ G YSLS+R + V HY
Sbjct: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHY 198
Query: 170 RVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPR----QDVWER 225
++ G Y+ F ++EL+ +Y + N L+ PC K +D WE
Sbjct: 199 KIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEI 258
Query: 226 PHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERL 285
S L R+LG G FG+VW G W GS VA+K +K M +E Q +K LRH++L
Sbjct: 259 SRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKL 318
Query: 286 IRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQR 345
++L+AV S EP+YIVTE M G+L FL PEG+ LRLP L+ A QVAEGM+Y+E
Sbjct: 319 VQLYAVVSE-EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMN 377
Query: 346 VVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQ 405
+HRDL A N+LV + LACK+ADFGLARL+KDD Y+P SK P+KWTAPEAA + F+
Sbjct: 378 YIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTI 437
Query: 406 KSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRS 465
KSDVWSFG+LL E+ T G+ PY GM E L+Q+ +GY +P P CPA +Y M + WR
Sbjct: 438 KSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRL 497
Query: 466 SPEERPSFATLREKL 480
PEERP+F L+ L
Sbjct: 498 DPEERPTFEYLQSFL 512
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 359 bits (922), Expect = 3e-99
Identities = 193/435 (44%), Positives = 261/435 (60%), Gaps = 12/435 (2%)
Query: 55 LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPET 114
LF+ALYD+ AR +L+ +G++ L G + R G +P +VA ++
Sbjct: 81 LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV--DS 138
Query: 115 LSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAK-----VCHY 169
+ + WYF + R A++ LLSP N GAFLIR SE++ G YSLS+R + V HY
Sbjct: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHY 198
Query: 170 RVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPR----QDVWER 225
++ G Y+ F ++EL+ +Y + N L+ PC K +D WE
Sbjct: 199 KIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEI 258
Query: 226 PHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERL 285
S L R+LG G FG+VW G W GS VA+K +K M +E Q +K LRH++L
Sbjct: 259 SRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKL 318
Query: 286 IRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQR 345
++L+AV S EP+YIVTE M G+L FL PEG+ LRLP L+ A QVAEGM+Y+E
Sbjct: 319 VQLYAVVSE-EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMN 377
Query: 346 VVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQ 405
+HRDL A N+LV + LACK+ADFGLARL+KDD Y+P SK P+KWTAPEAA + F+
Sbjct: 378 YIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTI 437
Query: 406 KSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRS 465
KSDVWSFG+LL E+ T G+ PY GM E L+Q+ +GY +P P CPA +Y M + WR
Sbjct: 438 KSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRL 497
Query: 466 SPEERPSFATLREKL 480
PEERP+F L+ L
Sbjct: 498 DPEERPTFEYLQSFL 512
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 355 bits (910), Expect = 7e-98
Identities = 190/438 (43%), Positives = 263/438 (60%), Gaps = 15/438 (3%)
Query: 55 LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPET 114
LF+ALYD+ AR +LS +G++ L G + R G +P +VA ++
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV--DS 143
Query: 115 LSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVR-----AQAKVCHY 169
+ + WYF + R A++ LLS N G FLIR SE++ G YSLS+R V HY
Sbjct: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY 203
Query: 170 RVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPC---MPQ----KAPRQDV 222
++ +G Y+ F L++L+ +Y + L+ PC MP+ +DV
Sbjct: 204 KIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDV 263
Query: 223 WERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRH 282
WE P L ++LG G FGEVW G W G+ VAIK +K M +E Q +K L+H
Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 323
Query: 283 ERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLE 342
++L++L+AV S EP+YIVTE M KG+L FL EGRAL+LP L+ A QVA GM+Y+E
Sbjct: 324 DKLVQLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 382
Query: 343 EQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRV 402
+HRDL + N+LV +GL CK+ADFGLARL++D+ Y+ +K P+KWTAPEAA Y
Sbjct: 383 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 442
Query: 403 FSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLEC 462
F+ KSDVWSFG+LL E+ T G+ PY GM N E L+Q+ RGYR+P P CP ++ LM+ C
Sbjct: 443 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 502
Query: 463 WRSSPEERPSFATLREKL 480
W+ PEERP+F L+ L
Sbjct: 503 WKKDPEERPTFEYLQSFL 520
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 354 bits (908), Expect = 1e-97
Identities = 202/469 (43%), Positives = 275/469 (58%), Gaps = 20/469 (4%)
Query: 21 PAGGEPD-HGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLC 79
PA EP G S D T P A P + F+ALYD+ +R +LS ++G+RL
Sbjct: 56 PAAAEPKLFGGFNSSDTVTSPQR---AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQ 112
Query: 80 ALE--EGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSP 137
+ EG ++ +GQ G +P +VA + +++ + WYF ++R ++++LLL+
Sbjct: 113 IVNNTEGDWWLAHSLSTGQ--TGYIPSNYVAPS--DSIQAEEWYFGKITRRESERLLLNA 168
Query: 138 PNEPGAFLIRPSESSLGGYSLSVRA--QAK---VCHYRVSMAADGSLYLQKGRLFPGLEE 192
N G FL+R SE++ G Y LSV AK V HY++ G Y+ F L++
Sbjct: 169 ENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQ 228
Query: 193 LLTYYKANWKLIQNPLLQPCMPQKAPRQ----DVWERPHSEFALGRKLGEGYFGEVWEGL 248
L+ YY + + + L C K Q D WE P L KLG+G FGEVW G
Sbjct: 229 LVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGT 288
Query: 249 WLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKG 308
W G+ VAIK +K M +E Q +K LRHE+L++L+AV S EP+YIVTE M KG
Sbjct: 289 WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKG 347
Query: 309 NLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVAD 368
+L FL G+ LRLP L+ A Q+A GM+Y+E VHRDL A N+LV + L CKVAD
Sbjct: 348 SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVAD 407
Query: 369 FGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYE 428
FGLARL++D+ Y+ +K P+KWTAPEAA Y F+ KSDVWSFG+LL E+ T G+ PY
Sbjct: 408 FGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP 467
Query: 429 GMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLR 477
GM N E L Q+ RGYR+P P CP ++ LM +CWR PEERP+F L+
Sbjct: 468 GMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQ 516
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 354 bits (908), Expect = 1e-97
Identities = 202/469 (43%), Positives = 275/469 (58%), Gaps = 20/469 (4%)
Query: 21 PAGGEPD-HGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLC 79
PA EP G S D T P A P + F+ALYD+ +R +LS ++G+RL
Sbjct: 56 PAAAEPKLFGGFNSSDTVTSPQR---AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQ 112
Query: 80 ALE--EGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSP 137
+ EG ++ +GQ G +P +VA + +++ + WYF ++R ++++LLL+
Sbjct: 113 IVNNTEGDWWLAHSLSTGQ--TGYIPSNYVAPS--DSIQAEEWYFGKITRRESERLLLNA 168
Query: 138 PNEPGAFLIRPSESSLGGYSLSVRA--QAK---VCHYRVSMAADGSLYLQKGRLFPGLEE 192
N G FL+R SE++ G Y LSV AK V HY++ G Y+ F L++
Sbjct: 169 ENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQ 228
Query: 193 LLTYYKANWKLIQNPLLQPCMPQKAPRQ----DVWERPHSEFALGRKLGEGYFGEVWEGL 248
L+ YY + + + L C K Q D WE P L KLG+G FGEVW G
Sbjct: 229 LVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGT 288
Query: 249 WLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKG 308
W G+ VAIK +K M +E Q +K LRHE+L++L+AV S EP+YIVTE M KG
Sbjct: 289 WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKG 347
Query: 309 NLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVAD 368
+L FL G+ LRLP L+ A Q+A GM+Y+E VHRDL A N+LV + L CKVAD
Sbjct: 348 SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVAD 407
Query: 369 FGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYE 428
FGLARL++D+ Y+ +K P+KWTAPEAA Y F+ KSDVWSFG+LL E+ T G+ PY
Sbjct: 408 FGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP 467
Query: 429 GMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLR 477
GM N E L Q+ RGYR+P P CP ++ LM +CWR PEERP+F L+
Sbjct: 468 GMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQ 516
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 354 bits (908), Expect = 1e-97
Identities = 195/448 (43%), Positives = 270/448 (60%), Gaps = 15/448 (3%)
Query: 42 PTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRL-SGQPSAG 100
P P E +ALYD+TA +L + +G++L L+ G + AR L +G+ G
Sbjct: 49 PPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGRE--G 106
Query: 101 LVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSV 160
VP VA+ E+L + W+F R +A++ LL+P N+ G+FLIR SE++ G +SLSV
Sbjct: 107 YVPSNFVARV--ESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSV 164
Query: 161 RAQAK----VCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCM--- 213
+ + HY++ +G Y+ FP L+ L+ +Y + L PC+
Sbjct: 165 KDVTTQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPA 224
Query: 214 PQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKE 273
PQ QD WE P L RKLG G FGEVW G + ++ VAIK +K M E
Sbjct: 225 PQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGE 284
Query: 274 IQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQ 333
+K L+HERL+RL+AV + EP+YIVTE M +G L FL T EG L LP L+ + Q
Sbjct: 285 ANVMKALQHERLVRLYAVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQ 343
Query: 334 VAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWT 393
+AEGM+Y+E +HRDL A N+LV + L CK+ADFGLAR++ D Y+ +K P+KWT
Sbjct: 344 IAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWT 402
Query: 394 APEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPA 453
APEA ++ VF+ K+DVWSFGVLL EV TYG+ PY GM+N E ++ + RGYR+PRP CP
Sbjct: 403 APEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPP 462
Query: 454 EVY-VLMLECWRSSPEERPSFATLREKL 480
E+Y ++ ECWRS PEERP+F L+ L
Sbjct: 463 ELYRGVIAECWRSRPEERPTFEFLQSVL 490
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 350 bits (897), Expect = 2e-96
Identities = 185/463 (39%), Positives = 275/463 (59%), Gaps = 19/463 (4%)
Query: 34 LDPNTDPVPTLPAEPCSPFP--------QLFLALYDFTARCGGELSVRRGDRLCALEEGG 85
+D T PVP P F + +ALY + +LS ++G+++ LEE G
Sbjct: 17 VDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHG 76
Query: 86 GYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFL 145
+ A+ L + G +P +VAK + TL + W+F ++R A++ LL+P N GAFL
Sbjct: 77 EWWKAKSLLTKKE-GFIPSNYVAKLN--TLETEEWFFKDITRKDAERQLLAPGNSAGAFL 133
Query: 146 IRPSESSLGGYSLSVRAQAKVC-----HYRVSMAADGSLYLQKGRLFPGLEELLTYYKAN 200
IR SE+ G +SLSVR V HY++ +G Y+ FP + +++ +Y+
Sbjct: 134 IRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQ 193
Query: 201 WKLIQNPLLQPCM---PQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAI 257
+ L + C+ PQK +D WE P L ++LG G FGEVW G + S VA+
Sbjct: 194 ADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAV 253
Query: 258 KVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTP 317
K +K M + +E +K L+H++L+RL+AV + EP+YI+TE M KG+L FL +
Sbjct: 254 KTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSD 313
Query: 318 EGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKD 377
EG + LP L+ F+ Q+AEGM+Y+E + +HRDL A NVLV + L CK+ADFGLAR+++D
Sbjct: 314 EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIED 373
Query: 378 DIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQ 437
+ Y+ +K P+KWTAPEA N+ F+ KSDVWSFG+LL+E+ TYG+ PY G TN + +
Sbjct: 374 NEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMT 433
Query: 438 QIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480
+ +GYR+PR CP E+Y +M CW+ EERP+F L+ L
Sbjct: 434 ALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVL 476
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 348 bits (894), Expect = 5e-96
Identities = 188/435 (43%), Positives = 262/435 (60%), Gaps = 12/435 (2%)
Query: 55 LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPET 114
LF+ALYD+ AR +LS +G++ L G + R G +P +VA ++
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV--DS 143
Query: 115 LSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVR-----AQAKVCHY 169
+ + WYF + R A++ LLS N G FLIR SE++ G YSLS+R V HY
Sbjct: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY 203
Query: 170 RVSMAADGSLYLQKGRLFPGLEELLTYY--KANWKLIQNPLL-QPCMPQKAP-RQDVWER 225
++ +G Y+ F L++L+ +Y KA+ ++ C PQ + +D WE
Sbjct: 204 KIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEV 263
Query: 226 PHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERL 285
L +KLG+G F EVW G W G+ VAIK +K M +E Q +K L+H++L
Sbjct: 264 ARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKL 323
Query: 286 IRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQR 345
++L+AV S EP+YIVTE M KG+L FL EGRAL+LP L+ A QVA GM+Y+E
Sbjct: 324 VQLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMN 382
Query: 346 VVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQ 405
+HRDL + N+LV +GL CK+ADFGLARL++D+ Y+ +K P+KWTAPEAA Y F+
Sbjct: 383 YIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 442
Query: 406 KSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRS 465
KSDVWSFG+LL E+ T G+ PY GM N E L+Q+ RGYR+P P CP ++ LM+ CW+
Sbjct: 443 KSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKK 502
Query: 466 SPEERPSFATLREKL 480
PEERP+F L+ L
Sbjct: 503 DPEERPTFEYLQSFL 517
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 348 bits (894), Expect = 5e-96
Identities = 189/469 (40%), Positives = 271/469 (57%), Gaps = 12/469 (2%)
Query: 21 PAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCA 80
P GG G + VP+ + +F+ALYD+ AR +LS ++G+R
Sbjct: 61 PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI 120
Query: 81 LEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNE 140
+ G + R G +P +VA A +++ + WYF + R A++LLL+P N+
Sbjct: 121 INNTEGDWWEARSIATGKNGYIPSNYVAPA--DSIQAEEWYFGKMGRKDAERLLLNPGNQ 178
Query: 141 PGAFLIRPSESSLGGYSLSVRAQAK-----VCHYRVSMAADGSLYLQKGRLFPGLEELLT 195
G FL+R SE++ G YSLS+R + V HY++ +G Y+ F L++L+
Sbjct: 179 RGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVK 238
Query: 196 YYKANWKLIQNPLLQPCMPQKAPRQ----DVWERPHSEFALGRKLGEGYFGEVWEGLWLG 251
+Y + + + L C K Q D WE P L KLG+G FGEVW G W G
Sbjct: 239 HYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG 298
Query: 252 SLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQ 311
+ VAIK +K M +E Q +K LRH++L+ L+AV S EP+YIVTE M KG+L
Sbjct: 299 TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSE-EPIYIVTEFMSKGSLL 357
Query: 312 AFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGL 371
FL +G+ L+LP L+ A Q+A+GM+Y+E +HRDL A N+LV + L CK+ADFGL
Sbjct: 358 DFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGL 417
Query: 372 ARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMT 431
ARL++D+ Y+ +K P+KWTAPEAA Y F+ KSDVWSFG+L E+ T G+ PY GM
Sbjct: 418 ARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMV 477
Query: 432 NHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480
N E L+Q+ RGYR+P P CP ++ LM CW+ P+ERP+F ++ L
Sbjct: 478 NREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL 526
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 347 bits (890), Expect = 1e-95
Identities = 178/434 (41%), Positives = 267/434 (61%), Gaps = 11/434 (2%)
Query: 55 LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPET 114
+ +ALY + +LS ++G+++ LEE G + A+ L + G +P +VAK + T
Sbjct: 67 IVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKE-GFIPSNYVAKLN--T 123
Query: 115 LSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVC-----HY 169
L + W+F ++R A++ LL+P N GAFLIR SE+ G +SLSVR V HY
Sbjct: 124 LETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHY 183
Query: 170 RVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCM---PQKAPRQDVWERP 226
++ +G Y+ FP + +++ +Y+ + L + C+ PQK +D WE P
Sbjct: 184 KIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIP 243
Query: 227 HSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLI 286
L ++LG G FGEVW G + S VA+K +K M + +E +K L+H++L+
Sbjct: 244 RESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLV 303
Query: 287 RLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRV 346
RL+AV + EP+YI+TE M KG+L FL + EG + LP L+ F+ Q+AEGM+Y+E +
Sbjct: 304 RLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNY 363
Query: 347 VHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQK 406
+HRDL A NVLV + L CK+ADFGLAR+++D+ Y+ +K P+KWTAPEA N+ F+ K
Sbjct: 364 IHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIK 423
Query: 407 SDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSS 466
SDVWSFG+LL+E+ TYG+ PY G TN + + + +GYR+PR CP E+Y +M CW+
Sbjct: 424 SDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEK 483
Query: 467 PEERPSFATLREKL 480
EERP+F L+ L
Sbjct: 484 AEERPTFDYLQSVL 497
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 312 bits (800), Expect = 4e-85
Identities = 176/445 (39%), Positives = 253/445 (56%), Gaps = 17/445 (3%)
Query: 44 LPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCAL--EEGGGYIFARRLSGQPSAGL 101
L A P P LF+ALYDF A LS+ +G++L L G + A+ +GQ G
Sbjct: 54 LLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ---GW 110
Query: 102 VPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVR 161
VP ++ + +L WY VSR A+ LL S N G+FL+R SESS G S+S+R
Sbjct: 111 VPSNYITPVN--SLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR 166
Query: 162 AQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQK----- 216
+ +V HYR++ A+DG LY+ F L EL+ ++ + L P +
Sbjct: 167 YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVY 226
Query: 217 --APRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLG-SLPVAIKVIKSANMKLTDLAKE 273
+P D WE ++ + KLG G +GEV+EG+W SL VA+K +K M++ + KE
Sbjct: 227 GVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKE 286
Query: 274 IQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQ 333
+K ++H L++L VC+ P YI+TE M GNL +L + + LL A Q
Sbjct: 287 AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQ 346
Query: 334 VAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWT 393
++ M YLE++ +HRDLAARN LV + KVADFGL+RL+ D Y+ + +K P+KWT
Sbjct: 347 ISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 406
Query: 394 APEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPA 453
APE+ Y FS KSDVW+FGVLL E+ TYG PY G+ + + + + YR+ RP CP
Sbjct: 407 APESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPE 466
Query: 454 EVYVLMLECWRSSPEERPSFATLRE 478
+VY LM CW+ +P +RPSFA + +
Sbjct: 467 KVYELMRACWQWNPSDRPSFAEIHQ 491
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 312 bits (800), Expect = 4e-85
Identities = 176/445 (39%), Positives = 253/445 (56%), Gaps = 17/445 (3%)
Query: 44 LPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCAL--EEGGGYIFARRLSGQPSAGL 101
L A P P LF+ALYDF A LS+ +G++L L G + A+ +GQ G
Sbjct: 73 LLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ---GW 129
Query: 102 VPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVR 161
VP ++ + +L WY VSR A+ LL S N G+FL+R SESS G S+S+R
Sbjct: 130 VPSNYITPVN--SLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR 185
Query: 162 AQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQK----- 216
+ +V HYR++ A+DG LY+ F L EL+ ++ + L P +
Sbjct: 186 YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVY 245
Query: 217 --APRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLG-SLPVAIKVIKSANMKLTDLAKE 273
+P D WE ++ + KLG G +GEV+EG+W SL VA+K +K M++ + KE
Sbjct: 246 GVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKE 305
Query: 274 IQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQ 333
+K ++H L++L VC+ P YI+TE M GNL +L + + LL A Q
Sbjct: 306 AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQ 365
Query: 334 VAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWT 393
++ M YLE++ +HRDLAARN LV + KVADFGL+RL+ D Y+ + +K P+KWT
Sbjct: 366 ISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 425
Query: 394 APEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPA 453
APE+ Y FS KSDVW+FGVLL E+ TYG PY G+ + + + + YR+ RP CP
Sbjct: 426 APESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPE 485
Query: 454 EVYVLMLECWRSSPEERPSFATLRE 478
+VY LM CW+ +P +RPSFA + +
Sbjct: 486 KVYELMRACWQWNPSDRPSFAEIHQ 510
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 307 bits (786), Expect = 2e-83
Identities = 171/431 (39%), Positives = 238/431 (55%), Gaps = 56/431 (12%)
Query: 55 LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPET 114
LF+ALYD+ AR +LS +G++ L G + R G +P +VA ++
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV--DS 143
Query: 115 LSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVR-----AQAKVCHY 169
+ + WYF + R A++ LLS N G FLIR SE++ G YSLS+R V HY
Sbjct: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY 203
Query: 170 RVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSE 229
++ +G Y+ F L++L+ +Y
Sbjct: 204 KIRKLDNGGYYITTRAQFETLQQLVQHYS------------------------------- 232
Query: 230 FALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLH 289
G W G+ VAIK +K M +E Q +K L+H++L++L+
Sbjct: 233 -----------------GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY 275
Query: 290 AVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHR 349
AV S EP+YIVTE M KG+L FL EGRAL+LP L+ A QVA GM+Y+E +HR
Sbjct: 276 AVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR 334
Query: 350 DLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDV 409
DL + N+LV +GL CK+ADFGLARL++D+ Y+ +K P+KWTAPEAA Y F+ KSDV
Sbjct: 335 DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 394
Query: 410 WSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEE 469
WSFG+LL E+ T G+ PY GM N E L+Q+ RGYR+P P CP ++ LM+ CW+ PEE
Sbjct: 395 WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEE 454
Query: 470 RPSFATLREKL 480
RP+F L+ L
Sbjct: 455 RPTFEYLQSFL 465
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 305 bits (781), Expect = 6e-83
Identities = 173/432 (40%), Positives = 247/432 (57%), Gaps = 17/432 (3%)
Query: 53 PQLFLALYDFTARCGGELSVRRGDRLCAL--EEGGGYIFARRLSGQPSAGLVPITHVAKA 110
P LF+ALYDF A LS+ +G++L L + G + R +GQ G VP ++
Sbjct: 94 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ---GWVPSNYITPV 150
Query: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYR 170
+ +L WY VSR+ A+ LL S N G+FL+R SESS G S+S+R + +V HYR
Sbjct: 151 N--SLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYR 206
Query: 171 VSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLL-------QPCMPQKAPRQDVW 223
++ ADG +Y+ F L EL+ ++ + L +P + +P D W
Sbjct: 207 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 266
Query: 224 ERPHSEFALGRKLGEGYFGEVWEGLWLG-SLPVAIKVIKSANMKLTDLAKEIQTLKGLRH 282
E ++ + KLG G +GEV+ G+W SL VA+K +K M++ + KE +K ++H
Sbjct: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 326
Query: 283 ERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLE 342
L++L VC+ P YIVTE M GNL +L + LL A Q++ M YLE
Sbjct: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386
Query: 343 EQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRV 402
++ +HRDLAARN LV + KVADFGL+RL+ D Y+ + +K P+KWTAPE+ Y
Sbjct: 387 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 446
Query: 403 FSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLEC 462
FS KSDVW+FGVLL E+ TYG PY G+ + + +GYR+ +P CP +VY LM C
Sbjct: 447 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 506
Query: 463 WRSSPEERPSFA 474
W+ SP +RPSFA
Sbjct: 507 WKWSPADRPSFA 518
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 305 bits (781), Expect = 6e-83
Identities = 173/432 (40%), Positives = 247/432 (57%), Gaps = 17/432 (3%)
Query: 53 PQLFLALYDFTARCGGELSVRRGDRLCAL--EEGGGYIFARRLSGQPSAGLVPITHVAKA 110
P LF+ALYDF A LS+ +G++L L + G + R +GQ G VP ++
Sbjct: 109 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ---GWVPSNYITPV 165
Query: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYR 170
+ +L WY VSR+ A+ LL S N G+FL+R SESS G S+S+R + +V HYR
Sbjct: 166 N--SLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYR 221
Query: 171 VSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLL-------QPCMPQKAPRQDVW 223
++ ADG +Y+ F L EL+ ++ + L +P + +P D W
Sbjct: 222 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 281
Query: 224 ERPHSEFALGRKLGEGYFGEVWEGLWLG-SLPVAIKVIKSANMKLTDLAKEIQTLKGLRH 282
E ++ + KLG G +GEV+ G+W SL VA+K +K M++ + KE +K ++H
Sbjct: 282 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 341
Query: 283 ERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLE 342
L++L VC+ P YIVTE M GNL +L + LL A Q++ M YLE
Sbjct: 342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 401
Query: 343 EQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRV 402
++ +HRDLAARN LV + KVADFGL+RL+ D Y+ + +K P+KWTAPE+ Y
Sbjct: 402 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 461
Query: 403 FSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLEC 462
FS KSDVW+FGVLL E+ TYG PY G+ + + +GYR+ +P CP +VY LM C
Sbjct: 462 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 521
Query: 463 WRSSPEERPSFA 474
W+ SP +RPSFA
Sbjct: 522 WKWSPADRPSFA 533
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 305 bits (781), Expect = 6e-83
Identities = 173/432 (40%), Positives = 247/432 (57%), Gaps = 17/432 (3%)
Query: 53 PQLFLALYDFTARCGGELSVRRGDRLCAL--EEGGGYIFARRLSGQPSAGLVPITHVAKA 110
P LF+ALYDF A LS+ +G++L L + G + R +GQ G VP ++
Sbjct: 88 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ---GWVPSNYITPV 144
Query: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYR 170
+ +L WY VSR+ A+ LL S N G+FL+R SESS G S+S+R + +V HYR
Sbjct: 145 N--SLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYR 200
Query: 171 VSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLL-------QPCMPQKAPRQDVW 223
++ ADG +Y+ F L EL+ ++ + L +P + +P D W
Sbjct: 201 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 260
Query: 224 ERPHSEFALGRKLGEGYFGEVWEGLWLG-SLPVAIKVIKSANMKLTDLAKEIQTLKGLRH 282
E ++ + KLG G +GEV+ G+W SL VA+K +K M++ + KE +K ++H
Sbjct: 261 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 320
Query: 283 ERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLE 342
L++L VC+ P YIVTE M GNL +L + LL A Q++ M YLE
Sbjct: 321 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 380
Query: 343 EQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRV 402
++ +HRDLAARN LV + KVADFGL+RL+ D Y+ + +K P+KWTAPE+ Y
Sbjct: 381 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 440
Query: 403 FSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLEC 462
FS KSDVW+FGVLL E+ TYG PY G+ + + +GYR+ +P CP +VY LM C
Sbjct: 441 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 500
Query: 463 WRSSPEERPSFA 474
W+ SP +RPSFA
Sbjct: 501 WKWSPADRPSFA 512
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 305 bits (781), Expect = 6e-83
Identities = 173/432 (40%), Positives = 247/432 (57%), Gaps = 17/432 (3%)
Query: 53 PQLFLALYDFTARCGGELSVRRGDRLCAL--EEGGGYIFARRLSGQPSAGLVPITHVAKA 110
P LF+ALYDF A LS+ +G++L L + G + R +GQ G VP ++
Sbjct: 94 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ---GWVPSNYITPV 150
Query: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYR 170
+ +L WY VSR+ A+ LL S N G+FL+R SESS G S+S+R + +V HYR
Sbjct: 151 N--SLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYR 206
Query: 171 VSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLL-------QPCMPQKAPRQDVW 223
++ ADG +Y+ F L EL+ ++ + L +P + +P D W
Sbjct: 207 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 266
Query: 224 ERPHSEFALGRKLGEGYFGEVWEGLWLG-SLPVAIKVIKSANMKLTDLAKEIQTLKGLRH 282
E ++ + KLG G +GEV+ G+W SL VA+K +K M++ + KE +K ++H
Sbjct: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 326
Query: 283 ERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLE 342
L++L VC+ P YIVTE M GNL +L + LL A Q++ M YLE
Sbjct: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386
Query: 343 EQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRV 402
++ +HRDLAARN LV + KVADFGL+RL+ D Y+ + +K P+KWTAPE+ Y
Sbjct: 387 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 446
Query: 403 FSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLEC 462
FS KSDVW+FGVLL E+ TYG PY G+ + + +GYR+ +P CP +VY LM C
Sbjct: 447 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 506
Query: 463 WRSSPEERPSFA 474
W+ SP +RPSFA
Sbjct: 507 WKWSPADRPSFA 518
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 305 bits (781), Expect = 6e-83
Identities = 173/432 (40%), Positives = 247/432 (57%), Gaps = 17/432 (3%)
Query: 53 PQLFLALYDFTARCGGELSVRRGDRLCAL--EEGGGYIFARRLSGQPSAGLVPITHVAKA 110
P LF+ALYDF A LS+ +G++L L + G + R +GQ G VP ++
Sbjct: 73 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ---GWVPSNYITPV 129
Query: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYR 170
+ +L WY VSR+ A+ LL S N G+FL+R SESS G S+S+R + +V HYR
Sbjct: 130 N--SLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYR 185
Query: 171 VSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLL-------QPCMPQKAPRQDVW 223
++ ADG +Y+ F L EL+ ++ + L +P + +P D W
Sbjct: 186 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 245
Query: 224 ERPHSEFALGRKLGEGYFGEVWEGLWLG-SLPVAIKVIKSANMKLTDLAKEIQTLKGLRH 282
E ++ + KLG G +GEV+ G+W SL VA+K +K M++ + KE +K ++H
Sbjct: 246 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 305
Query: 283 ERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLE 342
L++L VC+ P YIVTE M GNL +L + LL A Q++ M YLE
Sbjct: 306 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 365
Query: 343 EQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRV 402
++ +HRDLAARN LV + KVADFGL+RL+ D Y+ + +K P+KWTAPE+ Y
Sbjct: 366 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 425
Query: 403 FSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLEC 462
FS KSDVW+FGVLL E+ TYG PY G+ + + +GYR+ +P CP +VY LM C
Sbjct: 426 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 485
Query: 463 WRSSPEERPSFA 474
W+ SP +RPSFA
Sbjct: 486 WKWSPADRPSFA 497
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 278 bits (711), Expect = 8e-75
Identities = 171/462 (37%), Positives = 239/462 (51%), Gaps = 19/462 (4%)
Query: 40 PVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSA 99
P P +P E ++ +A+YDF A G +L + RG LE+ + + R +
Sbjct: 168 PPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRAR-DKYGNE 226
Query: 100 GLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLS 159
G +P +V L WY ++R++A+QLL S E G F++R S S G Y++S
Sbjct: 227 GYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKE-GGFMVRDS-SQPGLYTVS 284
Query: 160 V------RAQAKVCHYRV--SMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQP 211
+ + HY + + + YL + F + E++ Y+K N + L P
Sbjct: 285 LYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYP 344
Query: 212 CMPQ--KAPRQ-----DVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSAN 264
+ AP + WE SE R+LG G FG V G W VAIK I+
Sbjct: 345 VSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGA 404
Query: 265 MKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRL 324
M D +E + + L H +L++L+ VC+ +P+YIVTE M +G L FL +G R
Sbjct: 405 MCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR- 463
Query: 325 PPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSS 384
LL V EGM YLE +HRDLAARN LV + KV+DFG+AR + DD Y+ SS
Sbjct: 464 DVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSS 523
Query: 385 SSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYR 444
+K PVKW PE NY FS KSDVWSFGVL+ EVFT G+ P+E TN+E + + RG+R
Sbjct: 524 GAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHR 583
Query: 445 LPRPAACPAEVYVLMLECWRSSPEERPSFATLREKLHAIHRC 486
L +P VY +ML CW+ PE RPSF L + + C
Sbjct: 584 LYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVEC 625
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 276 bits (706), Expect = 3e-74
Identities = 171/489 (34%), Positives = 248/489 (50%), Gaps = 26/489 (5%)
Query: 2 EPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNT-DPVPTLPAEPCSPFPQLFLALY 60
E + +RR +LS +K G + P+ P+P LP + ALY
Sbjct: 40 EKYTQRRRPWLSQLSNK--------KQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALY 91
Query: 61 DFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPW 120
DF R L++RR + LE+ + + R + GL+P +V + L W
Sbjct: 92 DFLPREPCNLALRRAEEYLILEKYNPHWWKAR-DRLGNEGLIPSNYVTENKITNLEIYEW 150
Query: 121 YFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSV------RAQAKVCHYRVSMA 174
Y ++R QA+ LL E GAF++R S LG Y++SV +A + HY++
Sbjct: 151 YHRNITRNQAEHLLRQESKE-GAFIVRDSRH-LGSYTISVFMGARRSTEAAIKHYQIKKN 208
Query: 175 ADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQP------CMPQKAP-RQDVWERPH 227
G Y+ + F + EL+ Y++ N + L P C+P A + WE
Sbjct: 209 DSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDP 268
Query: 228 SEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIR 287
SE A +++G G FG V G W + VAIK I +M D +E + + L H +L++
Sbjct: 269 SELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQ 328
Query: 288 LHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVV 347
L+ VC +P+YIVTE M G L +L +G+ LR LL + EGM YLE +
Sbjct: 329 LYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYLERNGYI 387
Query: 348 HRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKS 407
HRDLAARN LV K++DFG+ R + DD Y S +K P+KW+ PE + +S KS
Sbjct: 388 HRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKS 447
Query: 408 DVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSP 467
DVWSFGVL+ EVFT G+ P+E +N + ++ I G+RL RP P +Y +M CW P
Sbjct: 448 DVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKP 507
Query: 468 EERPSFATL 476
E RP+FA L
Sbjct: 508 EGRPTFAEL 516
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 273 bits (698), Expect = 3e-73
Identities = 168/473 (35%), Positives = 244/473 (51%), Gaps = 32/473 (6%)
Query: 39 DPVPTLPAEPCSPFPQ------------LFLALYDFTARCGGELSVRRGDRLCALEEGGG 86
DP +P P P+ + +ALYD+ EL++RR + C L+
Sbjct: 147 DPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEI 206
Query: 87 YIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLI 146
+ + R G VP +++ + SP L WY +SR +A++LLL E GAF++
Sbjct: 207 HWW-RVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKE-GAFMV 264
Query: 147 RPSESSLGGYSLSVRAQAKVC-------HYRVSMAADGS--LYLQKGRLFPGLEELLTYY 197
R S ++ G Y++SV +A V HY + D Y+ + +F + L+ Y+
Sbjct: 265 RDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYH 323
Query: 198 KANWKLIQNPLLQPCM--PQKAP-----RQDVWERPHSEFALGRKLGEGYFGEVWEGLWL 250
+ N + L P QKAP R W SE +++G G FG V G WL
Sbjct: 324 QHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWL 383
Query: 251 GSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNL 310
VAIK I+ M D +E + + L H +L++L+ VC P+ +V E M G L
Sbjct: 384 NKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCL 443
Query: 311 QAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFG 370
+L T G LLG V EGM+YLEE V+HRDLAARN LV + KV+DFG
Sbjct: 444 SDYLRTQRG-LFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFG 502
Query: 371 LARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGM 430
+ R + DD Y+ S+ +K PVKW +PE ++ +S KSDVWSFGVL+ EVF+ G+ PYE
Sbjct: 503 MTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENR 562
Query: 431 TNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKLHAI 483
+N E ++ I G+RL +P VY +M CW+ PE+RP+F+ L +L I
Sbjct: 563 SNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEI 615
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 269 bits (688), Expect = 4e-72
Identities = 172/481 (35%), Positives = 246/481 (51%), Gaps = 42/481 (8%)
Query: 32 GSLDPNTD------PVPTLPAE------PCSPFP----------QLFLALYDFTARCGGE 69
GSL P + P+P P E P P P + +ALYD+ +
Sbjct: 173 GSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNAND 232
Query: 70 LSVRRGDRLCALEEGG-GYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRT 128
L +R+GD LEE + AR +GQ G +P +V +A +++ WY ++R+
Sbjct: 233 LQLRKGDEYFILEESNLPWWRARDKNGQE--GYIPSNYVTEAE-DSIEMYEWYSKHMTRS 289
Query: 129 QAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRA------QAKVCHYRVSMAADGSLYLQ 182
QA+QLL E G F++R S S G Y++SV A Q + HY V YL
Sbjct: 290 QAEQLLKQEGKE-GGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLA 347
Query: 183 KGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDV-------WERPHSEFALGRK 235
+ LF + EL+ Y++ N + + L P Q WE + ++
Sbjct: 348 EKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKE 407
Query: 236 LGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGG 295
LG G FG V G W G VAIK+IK +M + +E + + L HE+L++L+ VC+
Sbjct: 408 LGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQ 467
Query: 296 EPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARN 355
P++I+TE M G L +L R + LL V E M YLE ++ +HRDLAARN
Sbjct: 468 RPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARN 526
Query: 356 VLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVL 415
LV+D KV+DFGL+R + DD Y+ S SK PV+W+ PE Y FS KSD+W+FGVL
Sbjct: 527 CLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVL 586
Query: 416 LHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFAT 475
+ E+++ G+ PYE TN ET + I +G RL RP +VY +M CW +ERP+F
Sbjct: 587 MWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKI 646
Query: 476 L 476
L
Sbjct: 647 L 647
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 259 bits (663), Expect = 3e-69
Identities = 151/422 (35%), Positives = 229/422 (54%), Gaps = 20/422 (4%)
Query: 71 SVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQA 130
S+ R +RL E I S + + G ++ + S + L++Q WY + R +A
Sbjct: 411 SMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEA 470
Query: 131 QQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGL 190
Q+LL + G FL+R S G Y LSV + + H+ + ++Y +G F +
Sbjct: 471 QELL----KKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYV--DNMYRFEGTGFSNI 524
Query: 191 EELLTYYKANWKLIQNP----LLQPCMPQKAPRQDVWERPHSEFALGRKLGEGYFGEVWE 246
+L+ ++ ++I LL P P+ W H + LG LG+G FGEV++
Sbjct: 525 PQLIDHHYTTKQVITKKSGVVLLNPI-----PKDKKWILSHEDVILGELLGKGNFGEVYK 579
Query: 247 GLWLGSLPVAIKVIKS---ANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTE 303
G VA+K K +K+ L +E + LK H +++L VC+ +PVYI+ E
Sbjct: 580 GTLKDKTSVAVKTCKEDLPQELKIKFL-QEAKILKQYDHPNIVKLIGVCTQRQPVYIIME 638
Query: 304 LMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLA 363
L+ G+ FL + L+L L+ F+ A GM YLE + +HRDLAARN LV +
Sbjct: 639 LVSGGDFLTFLRRKKDE-LKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNV 697
Query: 364 CKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYG 423
K++DFG++R +YS S +IP+KWTAPEA NY +S +SDVWSFG+LL E F+ G
Sbjct: 698 LKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLG 757
Query: 424 QCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKLHAI 483
CPY GMTN + +Q+ RGYR+ P CP ++ +M++CW PE RP F+ L+++L I
Sbjct: 758 VCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTII 817
Query: 484 HR 485
R
Sbjct: 818 KR 819
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,395,102
Number of Sequences: 37866
Number of extensions: 1057977
Number of successful extensions: 5378
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 686
Number of HSP's successfully gapped in prelim test: 231
Number of HSP's that attempted gapping in prelim test: 3183
Number of HSP's gapped (non-prelim): 1116
length of query: 488
length of database: 18,247,518
effective HSP length: 106
effective length of query: 382
effective length of database: 14,233,722
effective search space: 5437281804
effective search space used: 5437281804
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.