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Search of human proteins with 18079323
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18079323 Gab3 protein isoform 2 [Homo sapiens]
(586 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18079323 Gab3 protein isoform 2 [Homo sapiens] 1193 0.0
gi|126091130 Gab3 protein isoform 1 [Homo sapiens] 1189 0.0
gi|18105042 GRB2-associated binding protein 2 isoform a [Homo sa... 302 5e-82
gi|46370073 GRB2-associated binding protein 1 isoform b [Homo sa... 243 4e-64
gi|6912460 GRB2-associated binding protein 2 isoform b [Homo sap... 238 9e-63
gi|46370071 GRB2-associated binding protein 1 isoform a [Homo sa... 228 1e-59
gi|83716021 GRB2-associated binding protein family, member 4 [Ho... 134 2e-31
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 52 2e-06
gi|221219024 pleckstrin homology-like domain, family B, member 1... 51 3e-06
gi|38424073 pleckstrin homology-like domain, family B, member 1 ... 51 3e-06
gi|221219026 pleckstrin homology-like domain, family B, member 1... 50 4e-06
gi|197313732 pleckstrin homology-like domain, family B, member 2... 49 1e-05
gi|197313730 pleckstrin homology-like domain, family B, member 2... 49 1e-05
gi|197313728 pleckstrin homology-like domain, family B, member 2... 49 1e-05
gi|21955172 pleckstrin homology-like domain, family B, member 2 ... 49 1e-05
gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [... 48 3e-05
gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [... 48 3e-05
gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [H... 48 3e-05
gi|157266264 pleckstrin homology-like domain, family B, member 3... 46 8e-05
gi|50234893 pleckstrin homology domain containing, family A (pho... 46 1e-04
gi|31377720 pleckstrin homology domain containing, family A (pho... 46 1e-04
gi|5031805 insulin receptor substrate 1 [Homo sapiens] 44 3e-04
gi|154354979 myosin X [Homo sapiens] 44 3e-04
gi|46391075 hypothetical protein LOC79949 [Homo sapiens] 44 4e-04
gi|24432056 hypothetical protein LOC144717 [Homo sapiens] 44 4e-04
gi|156616273 pleckstrin [Homo sapiens] 43 0.001
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 42 0.002
gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 41 0.003
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 41 0.003
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 41 0.003
>gi|18079323 Gab3 protein isoform 2 [Homo sapiens]
Length = 586
Score = 1193 bits (3087), Expect = 0.0
Identities = 586/586 (100%), Positives = 586/586 (100%)
Query: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI
Sbjct: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH
Sbjct: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
Query: 121 LEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLFL 180
LEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLFL
Sbjct: 121 LEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLFL 180
Query: 181 PDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSCH 240
PDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSCH
Sbjct: 181 PDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSCH 240
Query: 241 GSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKEL 300
GSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKEL
Sbjct: 241 GSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKEL 300
Query: 301 DIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVEG 360
DIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVEG
Sbjct: 301 DIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVEG 360
Query: 361 QSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNSG 420
QSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNSG
Sbjct: 361 QSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNSG 420
Query: 421 SISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTSF 480
SISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTSF
Sbjct: 421 SISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTSF 480
Query: 481 LSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFNS 540
LSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFNS
Sbjct: 481 LSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFNS 540
Query: 541 ASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV 586
ASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV
Sbjct: 541 ASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV 586
>gi|126091130 Gab3 protein isoform 1 [Homo sapiens]
Length = 587
Score = 1189 bits (3075), Expect = 0.0
Identities = 586/587 (99%), Positives = 586/587 (99%), Gaps = 1/587 (0%)
Query: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI
Sbjct: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH
Sbjct: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
Query: 121 LEDGA-DSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF 179
LEDGA DSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF
Sbjct: 121 LEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF 180
Query: 180 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC 239
LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC
Sbjct: 181 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC 240
Query: 240 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE 299
HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE
Sbjct: 241 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE 300
Query: 300 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE 359
LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE
Sbjct: 301 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE 360
Query: 360 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS 419
GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS
Sbjct: 361 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS 420
Query: 420 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS 479
GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS
Sbjct: 421 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS 480
Query: 480 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN 539
FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN
Sbjct: 481 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN 540
Query: 540 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV 586
SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV
Sbjct: 541 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV 587
>gi|18105042 GRB2-associated binding protein 2 isoform a [Homo
sapiens]
Length = 676
Score = 302 bits (774), Expect = 5e-82
Identities = 224/674 (33%), Positives = 338/674 (50%), Gaps = 104/674 (15%)
Query: 4 GDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63
GD VCTGWL KSPPE+KL+RYAW+KRWF+LR GRMSG+PDVLEYY+N HS KP+R+I+L+
Sbjct: 5 GDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLN 64
Query: 64 ECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLED 123
C G +F +KE Q++FVF +KT+ RTFYLVA+TE++M WV SI Q+C E+
Sbjct: 65 FCE-QVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQAEE 123
Query: 124 GADSMESLS-------YTPSSLQPSS------ASSLLTAHAASSSLPRDDP--NTNAVAT 168
DS+ ++S +P+ L SS S +H++ +L +P + + T
Sbjct: 124 STDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHMQPT 183
Query: 169 EETRSESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQ------------- 215
T + E L+L + E R S TR SD ++++
Sbjct: 184 LSTSAPQEYLYL-HQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCVNGIS 242
Query: 216 ------------ASFDDVFVDCLQPLPSSHLVHPSCHGS------GAQEVPSSRPQAALI 257
+ + F D LP S H GS ++V + + + +
Sbjct: 243 GQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFKTPSNTL 302
Query: 258 WSREINGPPRDHLS--SSPLLESSLSSTIQVDKNQGSLPCGAKELDIMSNTPPPRPPKPS 315
RE D++ ++PL + T +DKN ++ ++ PPPRPPKPS
Sbjct: 303 -CREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNAMTVATPGDSAIA--PPPRPPKPS 359
Query: 316 HLSERR---QEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKA-------------DVE 359
R ++ S + + +PRR +L +DN R +A +
Sbjct: 360 QAETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGESA 419
Query: 360 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAG---ASGLGPHCSPDDYIP 416
G+S + LP + + + S + ED+YVPM+P + A S YIP
Sbjct: 420 GRSAESMSDGVGSFLPGKMI-VGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYIP 478
Query: 417 MNSG-----SISSPLPELP--------ANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIRE 463
M+ G S+ P LP + ++PPPVNR+LKP RK++P PLDLRN ++I E
Sbjct: 479 MSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDE 538
Query: 464 ---HASLTRT-----RTVPCSRTSFLSPERNGINSARFFANPVSREDEESYIEMEEHRTA 515
+ +T++ T S + + P S + + S + EE+Y+ M+ +A
Sbjct: 539 LPFKSPITKSWSRANHTFNSSSSQYCRP-----ISTQSITSTDSGDSEENYVPMQNPVSA 593
Query: 516 SSLSSGALTWTKK---FSLDYLALDFNSASPAPMQQKLL--LSEEQRVDYVQVDEQKTQA 570
S + SG + K S+DYLALDF +SP+P ++ ++ +++VDYVQVD++KTQA
Sbjct: 594 SPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQA 653
Query: 571 LQSTKQEWTDERQS 584
LQ+T QEWTD RQS
Sbjct: 654 LQNTMQEWTDVRQS 667
>gi|46370073 GRB2-associated binding protein 1 isoform b [Homo
sapiens]
Length = 694
Score = 243 bits (620), Expect = 4e-64
Identities = 209/708 (29%), Positives = 318/708 (44%), Gaps = 149/708 (21%)
Query: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
MS G+ VC+GWL KSPPE+KL+RYAW++RWFVLR GR++G+PDVLEYY+N H+ KPIR+I
Sbjct: 1 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII 60
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
DL+ C G +F +KEF+N+++F + T R FYLVA +E+EM WV I +C
Sbjct: 61 DLNLCQ-QVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNP 119
Query: 121 LEDG------------ADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVAT 168
E+ AD +++ P S Q S+S+ L ++P P+ +
Sbjct: 120 TEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVP---PHLETLGI 176
Query: 169 EETRSESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQP 228
+E DYL+L NC++ + PTR + S S E D+V P
Sbjct: 177 QEDPQ--------DYLLLINCQSKKPE----PTRTHADSAKSTSSETDCNDNV------P 218
Query: 229 LPSSHLVHPSCHGSGA-------QEVPSSRPQAALIWSREINGP---------------- 265
+ S HG + P SR +A + S N P
Sbjct: 219 SHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSST 278
Query: 266 --------------------PRDHLSSSPLLESSLSSTIQVDKN--QGSLPCGAKELDIM 303
H+S S + + +T Q+ + +G+L +K LD +
Sbjct: 279 EADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSK-LDTI 337
Query: 304 SNTPPPRPPKPSHLSERRQEEW--------STHSGSKKPECTLVPRRISLSGLDNMRTWK 355
+ PPPRPPKP +R E T S P + P R + ++ +
Sbjct: 338 PDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLR 397
Query: 356 ADVEGQSLRHRDKRLSLNLPCRFSPMY------------PTASASIEDSYVPMSPQA--- 400
D Q + + + +S ++++YVPM+P +
Sbjct: 398 KDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPR 457
Query: 401 -GASGLGPHCSPDDYIPMNSGSI------------------SSPL--PELP---ANLEPP 436
+S +Y+PM G+ SSP P P A+ EPP
Sbjct: 458 QHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPP 517
Query: 437 PVNRDLKPQRKSRPPPLDLRNLSIIREHASLTR---TRTVPCSRTSF-LSPERNGINSAR 492
PV+R+LKP RK +P PL+++ L E + R TR+ + F +SP + ++S
Sbjct: 518 PVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTT 577
Query: 493 FFANPVSREDEESYIEMEEHRT--------ASSLSSGALTWTK---KFSLDYLALDFNSA 541
++ S + EE+Y+ M + + ++SL G+ K ++YL LD +S
Sbjct: 578 --SSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSG 635
Query: 542 -SPAPMQQKLLLS----EEQRVDYVQVDEQKTQALQSTKQEWTDERQS 584
S P +QK S ++RVDYV VD+QKT AL+ST++ WTD RQS
Sbjct: 636 KSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQS 683
>gi|6912460 GRB2-associated binding protein 2 isoform b [Homo
sapiens]
Length = 638
Score = 238 bits (608), Expect = 9e-63
Identities = 198/640 (30%), Positives = 306/640 (47%), Gaps = 104/640 (16%)
Query: 38 MSGNPDVLEYYRNKHSSKPIRVIDLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYL 97
MSG+PDVLEYY+N HS KP+R+I+L+ C G +F +KE Q++FVF +KT+ RTFYL
Sbjct: 1 MSGDPDVLEYYKNDHSKKPLRIINLNFCEQ-VDAGLTFNKKELQDSFVFDIKTSERTFYL 59
Query: 98 VAKTEQEMQVWVHSISQVCNLGHLEDGADSMESLSY-------TPSSLQPSSA------S 144
VA+TE++M WV SI Q+C E+ DS+ ++S +P+ L SS
Sbjct: 60 VAETEEDMNKWVQSICQICGFNQAEESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERK 119
Query: 145 SLLTAHAASSSLPRDDP--NTNAVATEETRSESELLFLPDYLVLSNCETGRLHHTSLPTR 202
S +H++ +L +P + + T T + E L+L + E R S TR
Sbjct: 120 SSAPSHSSQPTLFTFEPPVSNHMQPTLSTSAPQEYLYLHQ-CISRRAENARSASFSQGTR 178
Query: 203 CDSWSNSDRSLEQAS-------------------------FDDVFVDCLQPLPSSHLVHP 237
SD ++++ + + F D LP S H
Sbjct: 179 ASFLMRSDTAVQKLAQGNGHCVNGISGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHG 238
Query: 238 SCHGS------GAQEVPSSRPQAALIWSREINGPPRDHLS--SSPLLESSLSSTIQVDKN 289
GS ++V + + + + RE D++ ++PL + T +DKN
Sbjct: 239 HTKGSLTGSETDNEDVYTFKTPSNTL-CREFGDLLVDNMDVPATPLSAYQIPRTFTLDKN 297
Query: 290 QGSLPCGAKELDIMSNTPPPRPPKPSHLSERR---QEEWSTHSGSKKPECTLVPRRISLS 346
++ ++ PPPRPPKPS R ++ S + + +PRR +L
Sbjct: 298 HNAMTVATPGDSAIA--PPPRPPKPSQAETPRWGSPQQRPPISENSRSVAATIPRRNTLP 355
Query: 347 GLDNMRTWKA-------------DVEGQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSY 393
+DN R +A + G+S + LP + + + S + ED+Y
Sbjct: 356 AMDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMI-VGRSDSTNSEDNY 414
Query: 394 VPMSPQAG---ASGLGPHCSPDDYIPMNSG-----SISSPLPELPAN--------LEPPP 437
VPM+P + A S YIPM+ G S+ P LP + ++PPP
Sbjct: 415 VPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPP 474
Query: 438 VNRDLKPQRKSRPPPLDLRNLSIIRE---HASLTRT-----RTVPCSRTSFLSPERNGIN 489
VNR+LKP RK++P PLDLRN ++I E + +T++ T S + + P
Sbjct: 475 VNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRPI----- 529
Query: 490 SARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFS---LDYLALDFNSASPAPM 546
S + + S + EE+Y+ M+ +AS + SG + K S +DYLALDF +SP+P
Sbjct: 530 STQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPH 589
Query: 547 QQKLLLS--EEQRVDYVQVDEQKTQALQSTKQEWTDERQS 584
++ S +++VDYVQVD++KTQALQ+T QEWTD RQS
Sbjct: 590 RKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQS 629
>gi|46370071 GRB2-associated binding protein 1 isoform a [Homo
sapiens]
Length = 724
Score = 228 bits (581), Expect = 1e-59
Identities = 209/738 (28%), Positives = 318/738 (43%), Gaps = 179/738 (24%)
Query: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
MS G+ VC+GWL KSPPE+KL+RYAW++RWFVLR GR++G+PDVLEYY+N H+ KPIR+I
Sbjct: 1 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII 60
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
DL+ C G +F +KEF+N+++F + T R FYLVA +E+EM WV I +C
Sbjct: 61 DLNLCQ-QVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNP 119
Query: 121 LEDG------------ADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVAT 168
E+ AD +++ P S Q S+S+ L ++P P+ +
Sbjct: 120 TEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVP---PHLETLGI 176
Query: 169 EETRSESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQP 228
+E DYL+L NC++ + PTR + S S E D+V P
Sbjct: 177 QEDPQ--------DYLLLINCQSKKPE----PTRTHADSAKSTSSETDCNDNV------P 218
Query: 229 LPSSHLVHPSCHGSGA-------QEVPSSRPQAALIWSREINGP---------------- 265
+ S HG + P SR +A + S N P
Sbjct: 219 SHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSST 278
Query: 266 --------------------PRDHLSSSPLLESSLSSTIQVDKN--QGSLPCGAKELDIM 303
H+S S + + +T Q+ + +G+L +K LD +
Sbjct: 279 EADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSK-LDTI 337
Query: 304 SNTPPPRPPKPSHLSERRQEEW--------STHSGSKKPECTLVPRRISLSGLDNMRTWK 355
+ PPPRPPKP +R E T S P + P R + ++ +
Sbjct: 338 PDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLR 397
Query: 356 ADVEGQSLRHRDKRLSLNLPCRFSPMY------------PTASASIEDSYVPMSPQA--- 400
D Q + + + +S ++++YVPM+P +
Sbjct: 398 KDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPR 457
Query: 401 -GASGLGPHCSPDDYIPMNSGSI------------------SSPL--PELP---ANLEPP 436
+S +Y+PM G+ SSP P P A+ EPP
Sbjct: 458 QHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPP 517
Query: 437 PVNRDLKPQRKS------------------------------RPPPLDLRNLSIIREHAS 466
PV+R+LKP RK +P PL+++ L E +
Sbjct: 518 PVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQA 577
Query: 467 LTR---TRTVPCSRTSF-LSPERNGINSARFFANPVSREDEESYIEMEEHRT-------- 514
R TR+ + F +SP + ++S ++ S + EE+Y+ M + +
Sbjct: 578 PVRSPITRSFARDSSRFPMSPRPDSVHSTT--SSSDSHDSEENYVPMNPNLSSEDPNLFG 635
Query: 515 ASSLSSGALTWTK---KFSLDYLALDFNSA-SPAPMQQKLLLS----EEQRVDYVQVDEQ 566
++SL G+ K ++YL LD +S S P +QK S ++RVDYV VD+Q
Sbjct: 636 SNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQ 695
Query: 567 KTQALQSTKQEWTDERQS 584
KT AL+ST++ WTD RQS
Sbjct: 696 KTLALKSTREAWTDGRQS 713
>gi|83716021 GRB2-associated binding protein family, member 4 [Homo
sapiens]
Length = 574
Score = 134 bits (338), Expect = 2e-31
Identities = 71/160 (44%), Positives = 98/160 (61%), Gaps = 5/160 (3%)
Query: 3 AGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDL 62
+G + +GWL KSPPE+KL+ +AWRKRWF+LRRG+ S +PDVLEYY+N S KP+R I+L
Sbjct: 37 SGHVLYSGWLRKSPPEKKLRLFAWRKRWFILRRGQTSSDPDVLEYYKNDGSKKPLRTINL 96
Query: 63 SEC-AVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHL 121
+ C + V +F +KE Q ++F +KT+ RTFYLVA+T ++M WV SI Q+C
Sbjct: 97 NLCEQLDVDVTLNFNKKEIQKGYMFDIKTSERTFYLVAETREDMNEWVQSICQICGFRQE 156
Query: 122 ED----GADSMESLSYTPSSLQPSSASSLLTAHAASSSLP 157
E G S S S +PS + L +S P
Sbjct: 157 ESTGFLGNISSASHGLCSSPAEPSCSHQHLPQEQEPTSEP 196
Score = 76.3 bits (186), Expect = 8e-14
Identities = 75/221 (33%), Positives = 100/221 (45%), Gaps = 29/221 (13%)
Query: 386 SASIEDSYVPMSP---------QAGASGLGPHCSPDDYIPMNSGSISSPLPELPAN---- 432
S + E S VPM+P QAG G C P + + SPL EL +
Sbjct: 352 SIASEGSCVPMNPGSPTLPAVKQAGDDSQGV-CIPVGSCLVRFDLLGSPLTELSMHQDLS 410
Query: 433 ----LEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS--FLSPERN 486
++ PPVNR LKP +K+ P P +LRN +I E S T P S TS F S
Sbjct: 411 QGHEVQLPPVNRSLKPNQKANPTPPNLRNNRVINE-LSFKPPVTEPWSGTSHTFDSSSSQ 469
Query: 487 GINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFS---LDYLALDFNSASP 543
S + N S + E Y+ +A +S G + S + Y ALDF + P
Sbjct: 470 HPISTQSITNTDSEDSGERYL-FPNPASAFPVSGGTSSSAPPRSTGNIHYAALDFQPSKP 528
Query: 544 APMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQS 584
+ ++ ++VDYVQVD +KTQALQ T E RQS
Sbjct: 529 SIGS----VTSGKKVDYVQVDLEKTQALQKTMHEQMCLRQS 565
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 51.6 bits (122), Expect = 2e-06
Identities = 36/114 (31%), Positives = 56/114 (49%), Gaps = 23/114 (20%)
Query: 26 WRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWKHVGPSFVRKEFQNNFV 85
W+ RWF L R L+Y++++ S +PIR++DL+EC S V+ ++ V
Sbjct: 181 WKTRWFTLHRNE-------LKYFKDQMSPEPIRILDLTEC--------SAVQFDYSQERV 225
Query: 86 --FIVKTTSRTFYLVAKTEQEMQVWVH----SISQVCNLGHLEDGADSMESLSY 133
F + RTFYL AKT E W+ +SQ+ L G ++ S S+
Sbjct: 226 NCFCLVFPFRTFYLCAKTGVEADEWIKILRWKLSQIRK--QLNQGEGTIRSRSF 277
>gi|221219024 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 51.2 bits (121), Expect = 3e-06
Identities = 37/117 (31%), Positives = 58/117 (49%), Gaps = 20/117 (17%)
Query: 7 VCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS--E 64
VC G+LVK + K +W+KRWFV R + + L YY +KH +K VI E
Sbjct: 1258 VCRGYLVKMGGKIK----SWKKRWFVFDRLKRT-----LSYYVDKHETKLKGVIYFQAIE 1308
Query: 65 CAVWKHVGPSFVRKEFQNNFV---------FIVKTTSRTFYLVAKTEQEMQVWVHSI 112
+ H+ + ++ F+ V F VKT R +Y+VA + + M++W+ I
Sbjct: 1309 EVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVI 1365
>gi|38424073 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 51.2 bits (121), Expect = 3e-06
Identities = 37/117 (31%), Positives = 58/117 (49%), Gaps = 20/117 (17%)
Query: 7 VCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS--E 64
VC G+LVK + K +W+KRWFV R + + L YY +KH +K VI E
Sbjct: 1258 VCRGYLVKMGGKIK----SWKKRWFVFDRLKRT-----LSYYVDKHETKLKGVIYFQAIE 1308
Query: 65 CAVWKHVGPSFVRKEFQNNFV---------FIVKTTSRTFYLVAKTEQEMQVWVHSI 112
+ H+ + ++ F+ V F VKT R +Y+VA + + M++W+ I
Sbjct: 1309 EVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVI 1365
>gi|221219026 pleckstrin homology-like domain, family B, member 1
isoform b [Homo sapiens]
Length = 1319
Score = 50.4 bits (119), Expect = 4e-06
Identities = 36/108 (33%), Positives = 54/108 (50%), Gaps = 13/108 (12%)
Query: 7 VCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS--E 64
VC G+LVK + K +W+KRWFV R + + L YY +KH +K VI E
Sbjct: 1211 VCRGYLVKMGGKIK----SWKKRWFVFDRLKRT-----LSYYVDKHETKLKGVIYFQAIE 1261
Query: 65 CAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSI 112
+ H+ + K F VKT R +Y+VA + + M++W+ I
Sbjct: 1262 EVYYDHLRSA--AKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVI 1307
>gi|197313732 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 49.3 bits (116), Expect = 1e-05
Identities = 33/112 (29%), Positives = 49/112 (43%), Gaps = 9/112 (8%)
Query: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
+S + C G+L+K + K W+KRWFV R N YY +KH +K VI
Sbjct: 1139 VSITEKTCRGFLIKMGGKIK----TWKKRWFVFDR-----NKRTFSYYADKHETKLKGVI 1189
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSI 112
+ K F VKT R +Y+VA + + M++W+ I
Sbjct: 1190 YFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1241
>gi|197313730 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 49.3 bits (116), Expect = 1e-05
Identities = 33/112 (29%), Positives = 49/112 (43%), Gaps = 9/112 (8%)
Query: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
+S + C G+L+K + K W+KRWFV R N YY +KH +K VI
Sbjct: 1139 VSITEKTCRGFLIKMGGKIK----TWKKRWFVFDR-----NKRTFSYYADKHETKLKGVI 1189
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSI 112
+ K F VKT R +Y+VA + + M++W+ I
Sbjct: 1190 YFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1241
>gi|197313728 pleckstrin homology-like domain, family B, member 2
isoform b [Homo sapiens]
Length = 1237
Score = 49.3 bits (116), Expect = 1e-05
Identities = 33/112 (29%), Positives = 49/112 (43%), Gaps = 9/112 (8%)
Query: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
+S + C G+L+K + K W+KRWFV R N YY +KH +K VI
Sbjct: 1123 VSITEKTCRGFLIKMGGKIK----TWKKRWFVFDR-----NKRTFSYYADKHETKLKGVI 1173
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSI 112
+ K F VKT R +Y+VA + + M++W+ I
Sbjct: 1174 YFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1225
>gi|21955172 pleckstrin homology-like domain, family B, member 2
isoform c [Homo sapiens]
Length = 1210
Score = 49.3 bits (116), Expect = 1e-05
Identities = 33/112 (29%), Positives = 49/112 (43%), Gaps = 9/112 (8%)
Query: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
+S + C G+L+K + K W+KRWFV R N YY +KH +K VI
Sbjct: 1096 VSITEKTCRGFLIKMGGKIK----TWKKRWFVFDR-----NKRTFSYYADKHETKLKGVI 1146
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSI 112
+ K F VKT R +Y+VA + + M++W+ I
Sbjct: 1147 YFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1198
>gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 47.8 bits (112), Expect = 3e-05
Identities = 59/249 (23%), Positives = 93/249 (37%), Gaps = 37/249 (14%)
Query: 4 GDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63
G A C GWL K + W+K W +L+ L +Y N+ + K ++L
Sbjct: 41 GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNLP 93
Query: 64 ECAVWKHVGPSFVRKEFQNNFVF-IVKTTSRTFYLVAKTEQEMQVWVHSISQVC------ 116
+ V + E + F I +TFY A+ QEM VW++ +
Sbjct: 94 DFTVER-------ASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQEST 146
Query: 117 ---NLGHLEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRS 173
+ E + E + TP S S LTA ASSS P + + ++ E
Sbjct: 147 TKDEECYSESEQEDPEIAAETPPPPHASQTQS-LTAQQASSSSPSLSGTSYSFSSLENTV 205
Query: 174 ESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSH 233
++ F P L SLP +S S ++ + +F V P+PS
Sbjct: 206 KTPSSF-PSSL--------SKERQSLPDTVNSLSAAEDEGQPITF---AVQVHSPVPSEA 253
Query: 234 LVHPSCHGS 242
+H + S
Sbjct: 254 GIHKALENS 262
>gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 47.8 bits (112), Expect = 3e-05
Identities = 59/249 (23%), Positives = 93/249 (37%), Gaps = 37/249 (14%)
Query: 4 GDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63
G A C GWL K + W+K W +L+ L +Y N+ + K ++L
Sbjct: 41 GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNLP 93
Query: 64 ECAVWKHVGPSFVRKEFQNNFVF-IVKTTSRTFYLVAKTEQEMQVWVHSISQVC------ 116
+ V + E + F I +TFY A+ QEM VW++ +
Sbjct: 94 DFTVER-------ASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQEST 146
Query: 117 ---NLGHLEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRS 173
+ E + E + TP S S LTA ASSS P + + ++ E
Sbjct: 147 TKDEECYSESEQEDPEIAAETPPPPHASQTQS-LTAQQASSSSPSLSGTSYSFSSLENTV 205
Query: 174 ESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSH 233
++ F P L SLP +S S ++ + +F V P+PS
Sbjct: 206 KTPSSF-PSSL--------SKERQSLPDTVNSLSAAEDEGQPITF---AVQVHSPVPSEA 253
Query: 234 LVHPSCHGS 242
+H + S
Sbjct: 254 GIHKALENS 262
>gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [Homo
sapiens]
Length = 437
Score = 47.8 bits (112), Expect = 3e-05
Identities = 59/249 (23%), Positives = 93/249 (37%), Gaps = 37/249 (14%)
Query: 4 GDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63
G A C GWL K + W+K W +L+ L +Y N+ + K ++L
Sbjct: 40 GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNLP 92
Query: 64 ECAVWKHVGPSFVRKEFQNNFVF-IVKTTSRTFYLVAKTEQEMQVWVHSISQVC------ 116
+ V + E + F I +TFY A+ QEM VW++ +
Sbjct: 93 DFTVER-------ASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQEST 145
Query: 117 ---NLGHLEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRS 173
+ E + E + TP S S LTA ASSS P + + ++ E
Sbjct: 146 TKDEECYSESEQEDPEIAAETPPPPHASQTQS-LTAQQASSSSPSLSGTSYSFSSLENTV 204
Query: 174 ESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSH 233
++ F P L SLP +S S ++ + +F V P+PS
Sbjct: 205 KTPSSF-PSSL--------SKERQSLPDTVNSLSAAEDEGQPITF---AVQVHSPVPSEA 252
Query: 234 LVHPSCHGS 242
+H + S
Sbjct: 253 GIHKALENS 261
>gi|157266264 pleckstrin homology-like domain, family B, member 3
[Homo sapiens]
Length = 640
Score = 46.2 bits (108), Expect = 8e-05
Identities = 37/115 (32%), Positives = 49/115 (42%), Gaps = 13/115 (11%)
Query: 8 CTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS--EC 65
C G LVK K WRKRWF R L YY +K +K VI E
Sbjct: 535 CRGPLVKMGGRIK----TWRKRWFCFDRQARR-----LAYYADKEETKLKGVIYFQAIEE 585
Query: 66 AVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
+ H+ +F K F VKT R FY+VA + + M++W+ I + H
Sbjct: 586 VYYDHLRCAF--KSPNPRLTFCVKTYERLFYMVAPSPEAMRIWMDVIVTAADENH 638
>gi|50234893 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 45.8 bits (107), Expect = 1e-04
Identities = 25/88 (28%), Positives = 48/88 (54%), Gaps = 10/88 (11%)
Query: 26 WRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWKHVGPSFVRKEFQNNFV 85
W++R+F L + + + Y++++ +P+RVI L E + S + + +
Sbjct: 208 WKRRYFQL-------DENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDI---MMRDNL 257
Query: 86 FIVKTTSRTFYLVAKTEQEMQVWVHSIS 113
F + TTSRTFY+ A + +EM W+ ++S
Sbjct: 258 FEIVTTSRTFYVQADSPEEMHSWIKAVS 285
>gi|31377720 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 45.8 bits (107), Expect = 1e-04
Identities = 25/88 (28%), Positives = 48/88 (54%), Gaps = 10/88 (11%)
Query: 26 WRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWKHVGPSFVRKEFQNNFV 85
W++R+F L + + + Y++++ +P+RVI L E + S + + +
Sbjct: 208 WKRRYFQL-------DENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDI---MMRDNL 257
Query: 86 FIVKTTSRTFYLVAKTEQEMQVWVHSIS 113
F + TTSRTFY+ A + +EM W+ ++S
Sbjct: 258 FEIVTTSRTFYVQADSPEEMHSWIKAVS 285
>gi|5031805 insulin receptor substrate 1 [Homo sapiens]
Length = 1242
Score = 44.3 bits (103), Expect = 3e-04
Identities = 35/108 (32%), Positives = 49/108 (45%), Gaps = 14/108 (12%)
Query: 28 KRWFVLRRGRMSGNPDVLEYYRNK-----HSSKPIRVIDLSECAVWKHVGPSFVRKEFQN 82
KR+FVLR +G P LEYY N+ SS P R I L C R + +N
Sbjct: 27 KRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINK------RADSKN 80
Query: 83 NFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCN--LGHLEDGADSM 128
+ + T F + A +E E W ++ Q+ N GH DGA ++
Sbjct: 81 KHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH-HDGAAAL 127
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 44.3 bits (103), Expect = 3e-04
Identities = 41/168 (24%), Positives = 68/168 (40%), Gaps = 20/168 (11%)
Query: 2 SAGDAVCTGWL-VKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
S +A+ GWL K L R W+KRWFVLR+ + L Y+ N K +
Sbjct: 1209 SKQEALKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSK-------LMYFENDSEEKLKGTV 1261
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
++ + + N + I+ RTF+L+A++ ++ W +SQV
Sbjct: 1262 EV-------RTAKEIIDNTTKENGIDII-MADRTFHLIAESPEDASQWFSVLSQV--HAS 1311
Query: 121 LEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVAT 168
+ M P + + L+ + AS S D PN+ + T
Sbjct: 1312 TDQEIQEMHDEQANPQNAVGTLDVGLIDSVCASDS--PDRPNSFVIIT 1357
>gi|46391075 hypothetical protein LOC79949 [Homo sapiens]
Length = 363
Score = 43.9 bits (102), Expect = 4e-04
Identities = 42/162 (25%), Positives = 73/162 (45%), Gaps = 21/162 (12%)
Query: 11 WLVKSPPERKLQRY-AWRKRWFVLRR-GRMSGNPDVLEYYRNKHSSKPIRVIDLS--ECA 66
+ +KSPP + +W+KR+F+L + G S + L YY++ H I + S E
Sbjct: 26 YFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFS---LSYYKDHHHRGSIEIDQNSSVEVG 82
Query: 67 VWKHVGPSFVRKEFQ--NNFVFIVKTTSRTFYLVAKTEQEMQVWV-------HSISQVCN 117
+ V+K F+ + V ++TT+R ++L+ ++++ WV I
Sbjct: 83 ISSQEKMQSVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQ 142
Query: 118 LGHLEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRD 159
E + +L Y+ L PSS T+ A SS PR+
Sbjct: 143 NTEEELSLGNKRTLFYSSPLLGPSS-----TSEAVGSSSPRN 179
>gi|24432056 hypothetical protein LOC144717 [Homo sapiens]
Length = 249
Score = 43.9 bits (102), Expect = 4e-04
Identities = 31/93 (33%), Positives = 48/93 (51%), Gaps = 18/93 (19%)
Query: 25 AWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWKHVGPSFVRKEFQNNF 84
A+ +RWFVLR GN +L Y+ + S +P+ VI L C V E F
Sbjct: 33 AYHRRWFVLR-----GN--MLFYFEDAASREPVGVIILEGCTV--------ELVEAAEEF 77
Query: 85 VFIVK---TTSRTFYLVAKTEQEMQVWVHSISQ 114
F V+ T +RT+ L A+++ M+ WV ++S+
Sbjct: 78 AFAVRFAGTRARTYVLAAESQDAMEGWVKALSR 110
>gi|156616273 pleckstrin [Homo sapiens]
Length = 350
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/116 (27%), Positives = 46/116 (39%), Gaps = 9/116 (7%)
Query: 4 GDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63
G + G L+K RK W+ R F+LR +P L YY + P+ I L
Sbjct: 243 GVIIKQGCLLKQGHRRK----NWKVRKFILRE-----DPAYLHYYDPAGAEDPLGAIHLR 293
Query: 64 ECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLG 119
C V S RK + N I+ ++L A T +E W+ +I G
Sbjct: 294 GCVVTSVESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMASRTG 349
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 41.6 bits (96), Expect = 0.002
Identities = 34/120 (28%), Positives = 53/120 (44%), Gaps = 24/120 (20%)
Query: 5 DAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSE 64
+A+ GWL K K W RWFVL+ D L Y++++ +KP+ I L
Sbjct: 19 NAIKCGWLRKQGGFVK----TWHTRWFVLK-------GDQLYYFKDEDETKPLGTIFLPG 67
Query: 65 CAVWKHVGPSFVRKEFQNNFVFIV---------KTTSRTFYLVAKTEQEMQVWVHSISQV 115
V +H +E F+F V ++ L+A T+ +M+ WV SI +V
Sbjct: 68 NKVSEHP----CNEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRV 123
>gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform d [Homo sapiens]
Length = 1133
Score = 40.8 bits (94), Expect = 0.003
Identities = 41/140 (29%), Positives = 61/140 (43%), Gaps = 27/140 (19%)
Query: 10 GWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWK 69
GWL K+PP+ Y ++KRW L + D L Y+ + + R I + A
Sbjct: 87 GWLDKNPPQGS---YIYQKRWVRL-------DTDHLRYFDSNKDAYSKRFISV---ACIS 133
Query: 70 HVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLEDGADSME 129
HV +K F V T +RTF A+++ E + W+ ++ Q E A +
Sbjct: 134 HVAAIGDQK-------FEVITNNRTFAFRAESDVERKEWMQALQQAM----AEQRARARL 182
Query: 130 SLSY---TPSSLQPSSASSL 146
S +Y P S QP A SL
Sbjct: 183 SSAYLLGVPGSEQPDRAGSL 202
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform a [Homo sapiens]
Length = 1205
Score = 40.8 bits (94), Expect = 0.003
Identities = 41/140 (29%), Positives = 61/140 (43%), Gaps = 27/140 (19%)
Query: 10 GWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWK 69
GWL K+PP+ Y ++KRW L + D L Y+ + + R I + A
Sbjct: 87 GWLDKNPPQGS---YIYQKRWVRL-------DTDHLRYFDSNKDAYSKRFISV---ACIS 133
Query: 70 HVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLEDGADSME 129
HV +K F V T +RTF A+++ E + W+ ++ Q E A +
Sbjct: 134 HVAAIGDQK-------FEVITNNRTFAFRAESDVERKEWMQALQQAM----AEQRARARL 182
Query: 130 SLSY---TPSSLQPSSASSL 146
S +Y P S QP A SL
Sbjct: 183 SSAYLLGVPGSEQPDRAGSL 202
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform c [Homo sapiens]
Length = 1450
Score = 40.8 bits (94), Expect = 0.003
Identities = 41/140 (29%), Positives = 61/140 (43%), Gaps = 27/140 (19%)
Query: 10 GWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWK 69
GWL K+PP+ Y ++KRW L + D L Y+ + + R I + A
Sbjct: 332 GWLDKNPPQGS---YIYQKRWVRL-------DTDHLRYFDSNKDAYSKRFISV---ACIS 378
Query: 70 HVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLEDGADSME 129
HV +K F V T +RTF A+++ E + W+ ++ Q E A +
Sbjct: 379 HVAAIGDQK-------FEVITNNRTFAFRAESDVERKEWMQALQQAM----AEQRARARL 427
Query: 130 SLSY---TPSSLQPSSASSL 146
S +Y P S QP A SL
Sbjct: 428 SSAYLLGVPGSEQPDRAGSL 447
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,765,349
Number of Sequences: 37866
Number of extensions: 1420953
Number of successful extensions: 5657
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 187
Number of HSP's that attempted gapping in prelim test: 5326
Number of HSP's gapped (non-prelim): 443
length of query: 586
length of database: 18,247,518
effective HSP length: 108
effective length of query: 478
effective length of database: 14,157,990
effective search space: 6767519220
effective search space used: 6767519220
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.