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Search of human proteins with 17865632
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|17865632 mitochondrial tumor suppressor 1 isoform 5 [Homo
sapiens]
(436 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|17865632 mitochondrial tumor suppressor 1 isoform 5 [Homo sap... 845 0.0
gi|50348611 mitochondrial tumor suppressor 1 isoform 1 [Homo sap... 770 0.0
gi|50348617 mitochondrial tumor suppressor 1 isoform 2 [Homo sap... 770 0.0
gi|50348626 mitochondrial tumor suppressor 1 isoform 4 [Homo sap... 770 0.0
gi|140161498 hypothetical protein LOC23281 isoform a [Homo sapiens] 238 8e-63
gi|57768564 hypothetical protein LOC23281 isoform b [Homo sapiens] 219 3e-57
gi|45935391 coiled-coil domain containing 69 [Homo sapiens] 112 7e-25
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 77 2e-14
gi|71061468 centromere protein E [Homo sapiens] 77 4e-14
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 77 4e-14
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 75 1e-13
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 74 3e-13
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 73 4e-13
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 73 4e-13
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 73 4e-13
gi|55770834 centromere protein F [Homo sapiens] 73 4e-13
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 72 8e-13
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 72 1e-12
gi|31982906 cingulin-like 1 [Homo sapiens] 72 1e-12
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 72 1e-12
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 72 1e-12
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 71 2e-12
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 71 2e-12
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 71 2e-12
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 71 2e-12
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 71 2e-12
gi|21735548 centrosomal protein 2 [Homo sapiens] 71 2e-12
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 70 5e-12
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 70 5e-12
gi|124249396 coiled-coil domain containing 30 [Homo sapiens] 69 6e-12
>gi|17865632 mitochondrial tumor suppressor 1 isoform 5 [Homo
sapiens]
Length = 436
Score = 845 bits (2182), Expect = 0.0
Identities = 436/436 (100%), Positives = 436/436 (100%)
Query: 1 MLLSPKFSLSTIHIRLTAKGLLRNLRLPSGFRRSTVVFHTVEKSRQKNPRSLCIQPQTAP 60
MLLSPKFSLSTIHIRLTAKGLLRNLRLPSGFRRSTVVFHTVEKSRQKNPRSLCIQPQTAP
Sbjct: 1 MLLSPKFSLSTIHIRLTAKGLLRNLRLPSGFRRSTVVFHTVEKSRQKNPRSLCIQPQTAP 60
Query: 61 DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH 120
DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH
Sbjct: 61 DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH 120
Query: 121 KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTRE 180
KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTRE
Sbjct: 121 KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTRE 180
Query: 181 YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK 240
YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK
Sbjct: 181 YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK 240
Query: 241 KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM 300
KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM
Sbjct: 241 KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM 300
Query: 301 YLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK 360
YLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK
Sbjct: 301 YLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK 360
Query: 361 HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ 420
HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ
Sbjct: 361 HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ 420
Query: 421 SPRNSGSFPSPSISPR 436
SPRNSGSFPSPSISPR
Sbjct: 421 SPRNSGSFPSPSISPR 436
>gi|50348611 mitochondrial tumor suppressor 1 isoform 1 [Homo sapiens]
Length = 1270
Score = 770 bits (1989), Expect = 0.0
Identities = 404/436 (92%), Positives = 409/436 (93%), Gaps = 11/436 (2%)
Query: 3 LSPKFSLSTIHIRLTAKGLLRNLRLPSGFRRSTV--VFHTVEKSRQKNPRSLCIQPQTAP 60
L P S + +H+ T P G R + + VEKSRQKNPRSLCIQPQTAP
Sbjct: 844 LKPLVSRAHVHLMKTP---------PKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAP 894
Query: 61 DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH 120
DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH
Sbjct: 895 DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH 954
Query: 121 KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTRE 180
KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTRE
Sbjct: 955 KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTRE 1014
Query: 181 YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK 240
YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK
Sbjct: 1015 YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK 1074
Query: 241 KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM 300
KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM
Sbjct: 1075 KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM 1134
Query: 301 YLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK 360
YLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK
Sbjct: 1135 YLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK 1194
Query: 361 HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ 420
HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ
Sbjct: 1195 HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ 1254
Query: 421 SPRNSGSFPSPSISPR 436
SPRNSGSFPSPSISPR
Sbjct: 1255 SPRNSGSFPSPSISPR 1270
>gi|50348617 mitochondrial tumor suppressor 1 isoform 2 [Homo sapiens]
Length = 1216
Score = 770 bits (1989), Expect = 0.0
Identities = 404/436 (92%), Positives = 409/436 (93%), Gaps = 11/436 (2%)
Query: 3 LSPKFSLSTIHIRLTAKGLLRNLRLPSGFRRSTV--VFHTVEKSRQKNPRSLCIQPQTAP 60
L P S + +H+ T P G R + + VEKSRQKNPRSLCIQPQTAP
Sbjct: 790 LKPLVSRAHVHLMKTP---------PKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAP 840
Query: 61 DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH 120
DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH
Sbjct: 841 DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH 900
Query: 121 KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTRE 180
KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTRE
Sbjct: 901 KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTRE 960
Query: 181 YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK 240
YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK
Sbjct: 961 YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK 1020
Query: 241 KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM 300
KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM
Sbjct: 1021 KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM 1080
Query: 301 YLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK 360
YLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK
Sbjct: 1081 YLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK 1140
Query: 361 HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ 420
HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ
Sbjct: 1141 HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ 1200
Query: 421 SPRNSGSFPSPSISPR 436
SPRNSGSFPSPSISPR
Sbjct: 1201 SPRNSGSFPSPSISPR 1216
>gi|50348626 mitochondrial tumor suppressor 1 isoform 4 [Homo
sapiens]
Length = 517
Score = 770 bits (1989), Expect = 0.0
Identities = 404/436 (92%), Positives = 409/436 (93%), Gaps = 11/436 (2%)
Query: 3 LSPKFSLSTIHIRLTAKGLLRNLRLPSGFRRSTV--VFHTVEKSRQKNPRSLCIQPQTAP 60
L P S + +H+ T P G R + + VEKSRQKNPRSLCIQPQTAP
Sbjct: 91 LKPLVSRAHVHLMKTP---------PKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAP 141
Query: 61 DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH 120
DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH
Sbjct: 142 DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH 201
Query: 121 KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTRE 180
KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTRE
Sbjct: 202 KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTRE 261
Query: 181 YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK 240
YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK
Sbjct: 262 YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK 321
Query: 241 KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM 300
KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM
Sbjct: 322 KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM 381
Query: 301 YLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK 360
YLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK
Sbjct: 382 YLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK 441
Query: 361 HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ 420
HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ
Sbjct: 442 HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ 501
Query: 421 SPRNSGSFPSPSISPR 436
SPRNSGSFPSPSISPR
Sbjct: 502 SPRNSGSFPSPSISPR 517
>gi|140161498 hypothetical protein LOC23281 isoform a [Homo sapiens]
Length = 1379
Score = 238 bits (607), Expect = 8e-63
Identities = 145/411 (35%), Positives = 238/411 (57%), Gaps = 14/411 (3%)
Query: 28 PSGFRRSTVVFHTVEKSRQKNPRSLC-IQPQTAPDALPPEKTLELTQYKTKCENQSGFIL 86
P ST H+ +Q+ + P+ P A E+ L L + K +CE Q+ +
Sbjct: 965 PKRVAASTTKLHSPGYPKQRTAAARNGFPPKPDPQAREAERQLVL-RLKERCEQQTRQLG 1023
Query: 87 QLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEK 146
+ L F+AL V QH + E AL + K LS EL N+R E+ + CEKL+K
Sbjct: 1024 VAQGELKRAICGFDALAVATQHFFRKNESALVKEKELSIELANIRDEVAFHTAKCEKLQK 1083
Query: 147 ARNELQTVYEAFVQ----QHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQ 202
+ EL+ +E V+ Q QAE E E RL+ + E +L++ + ++ + Q QEQ
Sbjct: 1084 EKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQ 1143
Query: 203 FDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLE 262
++L A+H+ + LE+E +H+ + +L+ ++ + E+ HE+EKK LE+ + + SL+
Sbjct: 1144 VEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQ 1203
Query: 263 KQINDLKSENDALNEKLKSEEQ--KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKL 320
Q++ L ++ +L ++ + E+ ++ E+ + +LE++++SLK VLE+KN+++
Sbjct: 1204 DQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQI 1263
Query: 321 HQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLE 380
H+Q+ K++++EKL + N L +K++ QQ+NE+LKAR+D++ ++RQLS E A LQE +E
Sbjct: 1264 HEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVE 1323
Query: 381 KESKVNKRLSMENEELLWKLHNGDLCSP-KRSPTSSAIPLQSPRNSGSFPS 430
KE++ KRLS NEELLWKL GD SP K SPTS R S S PS
Sbjct: 1324 KETQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSPVY-----RGSSSGPS 1369
>gi|57768564 hypothetical protein LOC23281 isoform b [Homo sapiens]
Length = 348
Score = 219 bits (559), Expect = 3e-57
Identities = 125/332 (37%), Positives = 206/332 (62%), Gaps = 12/332 (3%)
Query: 106 IQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQ----Q 161
+Q L E AL + K LS EL N+R E+ + CEKL+K + EL+ +E V+ Q
Sbjct: 12 LQCLDKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQ 71
Query: 162 HQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASH 221
QAE E E RL+ + E +L++ + ++ + Q QEQ ++L A+H+ + LE+E +H
Sbjct: 72 QQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNH 131
Query: 222 SEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKS 281
+ + +L+ ++ + E+ HE+EKK LE+ + + SL+ Q++ L ++ +L ++ +
Sbjct: 132 TVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARR 191
Query: 282 EEQ--KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTA 339
E+ ++ E+ + +LE++++SLK VLE+KN+++H+Q+ K++++EKL + N
Sbjct: 192 FEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNII 251
Query: 340 LVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWK 399
L +K++ QQ+NE+LKAR+D++ ++RQLS E A LQE +EKE++ KRLS NEELLWK
Sbjct: 252 LEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWK 311
Query: 400 LHNGDLCSP-KRSPTSSAIPLQSPRNSGSFPS 430
L GD SP K SPTS R S S PS
Sbjct: 312 LQTGDPTSPIKLSPTSPVY-----RGSSSGPS 338
>gi|45935391 coiled-coil domain containing 69 [Homo sapiens]
Length = 296
Score = 112 bits (280), Expect = 7e-25
Identities = 68/229 (29%), Positives = 130/229 (56%), Gaps = 13/229 (5%)
Query: 175 EFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEA 234
E + ++ ++ + EE +K+ Q++++ +LE+ E+ +L+ E
Sbjct: 54 ERHQKDITRILQQHEEEKKKWAQQVEKE----------RELELRDRLDEQQRVLEGKNEE 103
Query: 235 SLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRARE-KAN 293
+L ++ +E EK++L E + ++ I+ L S+ +A K+K E+ +R K +
Sbjct: 104 ALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKH 163
Query: 294 LKN--PQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN 351
+++ + EQELESL V+E+KNE++H+ D +L+ ME + + N L +K+ QQEN
Sbjct: 164 IQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQEN 223
Query: 352 EELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKL 400
E+L R + +SRQLS + + +E+LEKE ++ ++L E EELL+++
Sbjct: 224 EDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRV 272
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 77.4 bits (189), Expect = 2e-14
Identities = 81/322 (25%), Positives = 151/322 (46%), Gaps = 61/322 (18%)
Query: 106 IQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAE 165
+Q L R+EALK++K+L +EL RG T E+L K+ ++++ Q A+
Sbjct: 1485 LQAALISRKEALKENKSLQEELSLARG-------TIERLTKSLADVES-------QVSAQ 1530
Query: 166 KTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKL 225
E++ L + E RD I E ++ ++ Q +L+++ E+ KL +E +K
Sbjct: 1531 NKEKDTVLGRLALLQEE--RDKLITEMDRSLLENQ----SLSSSCESLKLALEGLTEDKE 1584
Query: 226 ELLKK-------------AYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSEN 272
+L+K+ ++ E++K +EI +S E+ +S + E ++ + ++ E
Sbjct: 1585 KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYEN-VSNEAERIQHVVEAVRQEK 1643
Query: 273 DALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLK--------------AVLEIKNE 318
L KL+S E ++ EK Q+ EQE+E +K LE +N+
Sbjct: 1644 QELYGKLRSTEANKKETEK------QLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEND 1697
Query: 319 KLHQQ-----DIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQA 373
+L + D ME L+ +N ++ ++L+R + E E L + M+ LS E
Sbjct: 1698 RLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQ 1757
Query: 374 VLQESLEKESKVNKRLSMENEE 395
L+ + E V+K+ ++E E
Sbjct: 1758 DLKHQI--EGNVSKQANLEATE 1777
Score = 59.3 bits (142), Expect = 7e-09
Identities = 80/375 (21%), Positives = 165/375 (44%), Gaps = 69/375 (18%)
Query: 67 KTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHK-TLSQ 125
K EL+Q ++ E + I ++ QLL E L Q + E+++ + + ++++
Sbjct: 860 KVEELSQALSQKELE---ITKMDQLLLEKKRDVETL----QQTIEEKDQQVTEISFSMTE 912
Query: 126 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 185
++V L E + + L++ N L EA + E+ E +N + + Y+++
Sbjct: 913 KMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEA-----KKEQVEEDNEVSSGLKQNYDEMS 967
Query: 186 DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKA-------------- 231
+ K +LQ +FD L +E K +++A+ + ELL++
Sbjct: 968 PA----GQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDES 1023
Query: 232 -YEASLSEIKKGHEIE-----KKSLEDLLSEKQESLEKQINDLKSENDA--------LNE 277
E LSE ++G E+E K+ E ++ K + +E + SE + L E
Sbjct: 1024 KKEIPLSETERG-EVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEE 1082
Query: 278 KLKSEEQKRRAREKANL----KNPQIMYLEQELESLKAVLE---IKNEKLHQQDIKLMKM 330
KL +EEQ + ++ N K QI L+ E+ +A+++ N D +
Sbjct: 1083 KLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVK 1142
Query: 331 EKLVDN----------NTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLE 380
E +V + L +K+ ++E E+L+ ++ + L++ +A+L+++ E
Sbjct: 1143 ETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQE------ALTSRKAILKKAQE 1196
Query: 381 KESKVNKRLSMENEE 395
KE + + L + ++
Sbjct: 1197 KERHLREELKQQKDD 1211
Score = 53.9 bits (128), Expect = 3e-07
Identities = 77/353 (21%), Positives = 150/353 (42%), Gaps = 59/353 (16%)
Query: 107 QHLLSEREEALKQHKT-------LSQELVNLRGELVTASTTCEKLEKARNELQTV----- 154
+ LLS+ EE + + L EL +L+ +L S + EK ++ + L+ +
Sbjct: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQE 2346
Query: 155 ---------YEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQE---- 201
YE QA + E +RL E + +K+ + E ++ + E
Sbjct: 2347 ADIQNSKFSYEQLETDLQASR-ELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQ 2405
Query: 202 ------QFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDL-- 253
+ +NL + E + +E + + ++ + E +L IKK + +K L+
Sbjct: 2406 HDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLME-TLKTIKKENIQQKAQLDSFVK 2464
Query: 254 ------------------LSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAR-EKANL 294
L E+ S+ + + L E A N KLK E + R+ + N
Sbjct: 2465 SMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNS 2524
Query: 295 KNPQI-MYLEQELESLKAVLEIKNEKLHQQ-DIKLMKMEKLVDNNTALVDKLKRFQQENE 352
+N ++ L Q E L V+ IK+ + Q +++L + ++L + L +KLK ++ NE
Sbjct: 2525 ENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANE 2584
Query: 353 ELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDL 405
+L+ + + LS E L+ S+ S++ ++++ EE L++ L
Sbjct: 2585 DLRRSFNALQEEKQDLSKEIESLKVSI---SQLTRQVTALQEEGTLGLYHAQL 2634
Score = 51.6 bits (122), Expect = 1e-06
Identities = 66/293 (22%), Positives = 136/293 (46%), Gaps = 24/293 (8%)
Query: 119 QHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYT 178
Q K + E V L EL +STT E +K+ Q + Q + E + + E +
Sbjct: 1310 QLKEIEAEKVEL--ELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHA 1367
Query: 179 REYE-KLRDTYIEEAE-KYKMQLQEQFDNLNAAHETSKLEIEASH-----SEKLELLKKA 231
+ KL + ++ A ++ +LQ + D L SK E + S+ SEK L K
Sbjct: 1368 ESLQQKLESSQLQIAGLEHLRELQPKLDELQKL--ISKKEEDVSYLSGQLSEKEAALTKI 1425
Query: 232 YEASLSE---IKKGH-EIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRR 287
+ + IK H ++E ++ E E+ + L+ ++ ++K + + + E+ ++++Q +R
Sbjct: 1426 QTEIIEQEDLIKALHTQLEMQAKEH--DERIKQLQVELCEMKQKPEEIGEESRAKQQIQR 1483
Query: 288 AREKANLKNPQIMY----LEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDK 343
+ A + + + L++EL + +E + L + ++ K D ++ +
Sbjct: 1484 KLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT---VLGR 1540
Query: 344 LKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 396
L Q+E ++L MD+ + ++ LS+ L+ +LE ++ ++L E E L
Sbjct: 1541 LALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL 1593
Score = 50.1 bits (118), Expect = 4e-06
Identities = 74/349 (21%), Positives = 146/349 (41%), Gaps = 47/349 (13%)
Query: 87 QLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEK 146
++K L C + E +++ E K++ Q G A E L++
Sbjct: 1957 EMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKE 2016
Query: 147 ARNELQTVYEAFVQ-QHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDN 205
+ E++ + + ++ Q + ER + EF E +K +E ++ Q E
Sbjct: 2017 KQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK----DLEITKENLAQAVEHRKK 2072
Query: 206 LNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQI 265
A + K+ ++ + SE +L A ++KK + K+S++ + +K E LE+++
Sbjct: 2073 AQAELASFKVLLDDTQSEAARVL-----ADNLKLKKELQSNKESVKSQMKQKDEDLERRL 2127
Query: 266 -----------NDLKSENDAL-NEKLKSEEQKRRAREKANLKNPQIMYLEQELESL---- 309
+++ + DAL EK+ EE + N K+ ++ L++ L+S
Sbjct: 2128 EQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQL 2187
Query: 310 ---------------KAVLEIKNEKLHQQDIKLMKMEKL---VDNNTALVDKLKRFQQEN 351
+ + E K + D K E++ DN + L D+L++
Sbjct: 2188 AAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHM 2247
Query: 352 EELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKL 400
EELK + + + +Q+ +A Q ++ + KV L EN+ELL +L
Sbjct: 2248 EELKINISR-LEHDKQIWESKA--QTEVQLQQKVCDTLQGENKELLSQL 2293
Score = 50.1 bits (118), Expect = 4e-06
Identities = 62/346 (17%), Positives = 147/346 (42%), Gaps = 29/346 (8%)
Query: 74 YKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGE 133
Y+ E IL+ QL+ + L I+ L S ++ ++ L EL+ R +
Sbjct: 2480 YQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRED 2539
Query: 134 LVTASTTCEKLEKARNELQTVYEAFVQQHQA---EKTERENRLKEFYTREYEKLRD---T 187
L T + +K E+Q ++ A EK + E R + L++
Sbjct: 2540 LNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQD 2599
Query: 188 YIEEAEKYKMQLQEQFDNLNAAHET-------SKLEIEASHSEKLELLKKAYEASLSEIK 240
+E E K+ + + + A E ++L+++ +L L + + ++E++
Sbjct: 2600 LSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELE 2659
Query: 241 KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQK--RRAREKANLKNPQ 298
+ +K + E ++ L+K++ L + + + ++ E++ AR+ ++
Sbjct: 2660 EELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKL 2719
Query: 299 IMY------LEQELESL-KAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN 351
+M L +++S +++ ++N + H + +L ++++ D + LK Q
Sbjct: 2720 LMVTKENKGLTAQIQSFGRSMSSLQNSRDHANE-ELDELKRKYDAS------LKELAQLK 2772
Query: 352 EELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELL 397
E+ ++ +S + + + SL K+N++L ++E+LL
Sbjct: 2773 EQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLL 2818
Score = 48.5 bits (114), Expect = 1e-05
Identities = 60/262 (22%), Positives = 121/262 (46%), Gaps = 29/262 (11%)
Query: 163 QAEKTERENRLKEFYTREYEKLR--DTYIEEAEKY-------KMQLQEQFDNLNAAHETS 213
Q E+ +N++K+ KL + YIEE + + Q +EQ + +
Sbjct: 83 QEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE 142
Query: 214 KLEIEASH---SEKLELLKKAYEASLSEIKKGHEIEKKS-LEDLLSEKQESLEKQ--IND 267
++EIE EK EL+ +A L++ + + + +E+ + KQ+ EK+ I+
Sbjct: 143 EMEIEKIKHKLQEKEELIS-TLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFIST 201
Query: 268 LKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKL 327
L+++ L++ + ++ REK Q+ E EL L +++ E QQ +++
Sbjct: 202 LQAQ---LSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEM--QQKLRV 256
Query: 328 MKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQL---STEQAVLQESLEKESK 384
++ KL ++ +LV + + +EL A ++ +S+QL E L+ ++E E +
Sbjct: 257 LQ-RKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETERE 315
Query: 385 VNK----RLSMENEELLWKLHN 402
+K ++ +E E HN
Sbjct: 316 ESKILLEKMELEVAERKLSFHN 337
Score = 48.1 bits (113), Expect = 2e-05
Identities = 75/356 (21%), Positives = 147/356 (41%), Gaps = 41/356 (11%)
Query: 69 LELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELV 128
LE+ KT L+Q L + L ++ L + +E K +++
Sbjct: 1351 LEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEH-LRELQPKLDELQKLISKKEEDVS 1409
Query: 129 NLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYE-KLRDT 187
L G+L K++ E + + +A Q + + E + R+K+ E K +
Sbjct: 1410 YLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPE 1469
Query: 188 YIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHS--EKLELLKKAYEA---SLSEIKKG 242
I E + K Q+Q + L AA + K ++ + S E+L L + E SL++++
Sbjct: 1470 EIGEESRAKQQIQRK---LQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQ 1526
Query: 243 HEIEKKSLED------LLSEKQESLEKQINDLKSENDALNEKLKS---------EEQKRR 287
+ K + LL E+++ L +++ EN +L+ +S E++++
Sbjct: 1527 VSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKL 1586
Query: 288 AREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRF 347
+E +LK+ +I + E K E + +I L E + + + ++
Sbjct: 1587 VKEIESLKSSKIAESTEWQEKHK-------ELQKEYEILLQSYENVSNEAERIQHVVEAV 1639
Query: 348 QQENEELKARMDKHMA----ISRQLSTEQAVLQESLEK-----ESKVNKRLSMENE 394
+QE +EL ++ A +QL + ++E EK +SK K L +E E
Sbjct: 1640 RQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEE 1695
Score = 45.4 bits (106), Expect = 1e-04
Identities = 49/220 (22%), Positives = 98/220 (44%), Gaps = 14/220 (6%)
Query: 190 EEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKS 249
E ++ QE A E +E++ +K L++ EA L E +K + + K
Sbjct: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEA-LQEERKAADNKIKK 95
Query: 250 LEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESL 309
L+ K SL K I ++K++ + E++ +K++ + E E+E +
Sbjct: 96 LKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE------EMEIEKI 149
Query: 310 KAVLEIKNEKLH--QQDIKLMKMEKLVDNNTALVD--KLKRFQQENEELKARMDKHMAIS 365
K L+ K E + Q + + E+ ++T + + +K+ QE EE + + ++
Sbjct: 150 KHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLS-- 207
Query: 366 RQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDL 405
Q EQA Q EK+++ ++ + +ELL + D+
Sbjct: 208 -QTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADV 246
Score = 42.0 bits (97), Expect = 0.001
Identities = 75/356 (21%), Positives = 148/356 (41%), Gaps = 58/356 (16%)
Query: 70 ELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVN 129
EL + K K + + QLK+ + L+ + S E +L + L+Q+L++
Sbjct: 2753 ELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLS 2812
Query: 130 LRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRD--- 186
+L+ S+ +LE + N++Q+ +A Q E+ N L++F E K R
Sbjct: 2813 KDEQLLHLSS---QLEDSYNQVQSFSKAMASL-QNERDHLWNELEKFRKSEEGKQRSAAQ 2868
Query: 187 -----TYIEEAEKYKMQLQEQFD-------NLNAAHETSKLEIEASHSEKLELLK----- 229
++ +K LQ D NL + EI H K +L +
Sbjct: 2869 PSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKT 2928
Query: 230 KAYEASLSEIKK-----GHEIEKKSLED----------------LLSEKQES---LEKQI 265
KA++ E+++ HE+ + +E +S+K + L+ I
Sbjct: 2929 KAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLI 2988
Query: 266 NDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDI 325
+L+S + + + LK + Q R+A + + L E E L+ L +++HQ+++
Sbjct: 2989 RELRS-SSSQTQPLKVQYQ-RQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKEL 3046
Query: 326 KLMKM-----EKLVDNNTALVDKLKRFQ--QENEELKARMDKHMAI-SRQLSTEQA 373
++ ++ + L + NT + Q +EN++ + H A+ +Q+ QA
Sbjct: 3047 RIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQA 3102
Score = 41.6 bits (96), Expect = 0.001
Identities = 42/201 (20%), Positives = 89/201 (44%), Gaps = 2/201 (0%)
Query: 198 QLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEK-KSLEDLLSE 256
Q++ Q + A +L++ ++ SE + ++ ++ K+G EIE K++
Sbjct: 1306 QIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEV 1365
Query: 257 KQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVL-EI 315
ESL++++ + + L + + + ++ + K + YL +L +A L +I
Sbjct: 1366 HAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKI 1425
Query: 316 KNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVL 375
+ E + Q+D+ +L +++K+ Q E E+K + ++ SR Q L
Sbjct: 1426 QTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL 1485
Query: 376 QESLEKESKVNKRLSMENEEL 396
Q +L + K EEL
Sbjct: 1486 QAALISRKEALKENKSLQEEL 1506
Score = 38.9 bits (89), Expect = 0.009
Identities = 55/236 (23%), Positives = 102/236 (43%), Gaps = 22/236 (9%)
Query: 67 KTLELTQYKTKCENQSGFIL--QLKQLLACGNTKFEALTVVIQH--LLSEREEALKQHKT 122
+ ++L Q + Q IL QL+Q+ A NT + + +L E+ E +
Sbjct: 273 QVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERK 332
Query: 123 LSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYT--RE 180
LS NL+ E+ E+ +A+ EL++ Y A Q+H+AE E+ + + +E
Sbjct: 333 LSFH--NLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQE 390
Query: 181 YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEK-----LELLKKAYEAS 235
+ D ++ K EQ + +A +LE + K L L +
Sbjct: 391 LQSACDALKDQNSKLLQDKNEQ--AVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHET 448
Query: 236 LSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDAL------NEKLKSEEQK 285
S+ ++ + + + E SL+K++ +L++E AL E+LK+E +K
Sbjct: 449 ASQ-TSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEK 503
Score = 38.9 bits (89), Expect = 0.009
Identities = 70/313 (22%), Positives = 126/313 (40%), Gaps = 52/313 (16%)
Query: 118 KQHKTLSQELVN--LRGELVTASTTC---------------EKLEKARNELQTVYEAFVQ 160
KQ K L E N LR E+ A T E+LE+ + E +T+ + F Q
Sbjct: 1685 KQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKF-Q 1743
Query: 161 QHQAEKTERENRLKEF-YTREYEKLRDTYIEEAEKYKMQLQ------EQFDNLNAAHETS 213
+EK +++ + E + +E EK+ Q + ++
Sbjct: 1744 SLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSL 1803
Query: 214 KLEIEASHSEKLELLKKAYEASLSEIKKGHEIE---------KKSLEDLLSEKQ------ 258
+ + SE + K A A + EI K+ + L EKQ
Sbjct: 1804 SMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFS 1863
Query: 259 ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNE 318
++LE + N L S+ + +LK +++ K NL N QI ++EL + + E E
Sbjct: 1864 QTLENEKNTLLSQISTKDGELKMLQEE---VTKMNLLNQQI---QEELSRVTKLKETAEE 1917
Query: 319 KLHQQDIKLMKMEKLVDNNTAL---VDKLKRFQQENEELKARMDKHMAISRQLSTE-QAV 374
+ + D++ M +L + N ++ + Q +NE L++ M +L E Q +
Sbjct: 1918 E--KDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQL 1975
Query: 375 LQESLEKESKVNK 387
++E + ES++ K
Sbjct: 1976 VKEKTKVESEIRK 1988
Score = 38.9 bits (89), Expect = 0.009
Identities = 70/350 (20%), Positives = 144/350 (41%), Gaps = 34/350 (9%)
Query: 87 QLKQLLACG---NTKFEALTVVIQHLLSEREEA----LKQHKTLSQELVNLRGELVTAST 139
Q KQLL N + E ++ L E EEA + L +E +L E+ +
Sbjct: 2550 QQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKV 2609
Query: 140 TCEKLEKARNELQTVYEAFVQQHQAEKTERE-NRLKEFYTREYEKLRDTYIE------EA 192
+ +L + LQ + Q + E E +RL ++ +++ + E EA
Sbjct: 2610 SISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEA 2669
Query: 193 EK----YKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEAS-----LSEIKKGH 243
K + +L+++ +L+ + E E + EL + E +++ KG
Sbjct: 2670 AKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGL 2729
Query: 244 EIEKKSLEDLLSEKQESLE---KQINDLKSENDA-LNEKLKSEEQKRRAREKANLKNPQI 299
+ +S +S Q S + +++++LK + DA L E + +EQ RE+ L +
Sbjct: 2730 TAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETA 2789
Query: 300 MYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKR----FQQENEELK 355
+ E+ + LE N++L +D +L+ + ++++ V + Q E + L
Sbjct: 2790 FSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLW 2849
Query: 356 ARMDKHMAI---SRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHN 402
++K ++ + + + ++ K L + + LL +L N
Sbjct: 2850 NELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKN 2899
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 76.6 bits (187), Expect = 4e-14
Identities = 84/352 (23%), Positives = 156/352 (44%), Gaps = 34/352 (9%)
Query: 66 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ 125
EK EL Q+K + + + ++ + + + IQ ++ E+EE + + L
Sbjct: 1545 EKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQI 1604
Query: 126 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTR------ 179
E L+ T + E E Q + V + Q + E E+ ++F T+
Sbjct: 1605 ERDQLKEN--TKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLEN 1662
Query: 180 -EYEKLRDTYI--EEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASL 236
E E +R T I E E+ + +E+ D+L + ET K+E + E + + E
Sbjct: 1663 IETENIRLTQILHENLEEMRSVTKER-DDLRSVEETLKVERDQLKENLRETITRDLEKQ- 1720
Query: 237 SEIK------KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALN-EKLKSEEQKRRAR 289
E+K K H+ L ++SEK + DL+ NDAL + LK +E+ R A
Sbjct: 1721 EELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAH 1780
Query: 290 EKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQ 349
M+L+++ E++ + I +EK KL M+K ++N+ A + + + +
Sbjct: 1781 ----------MHLKEQQETIDKLRGIVSEKTD----KLSNMQKDLENSNAKLQEKIQELK 1826
Query: 350 ENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLH 401
NE + K + +++ +E L++ ++ +S +L +EN L KLH
Sbjct: 1827 ANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLH 1878
Score = 63.2 bits (152), Expect = 5e-10
Identities = 75/333 (22%), Positives = 152/333 (45%), Gaps = 32/333 (9%)
Query: 88 LKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ---ELVNLRGELVTASTTCEKL 144
L++ + K E L +V HL +E K +S+ E+ N++ +L ++ +
Sbjct: 1709 LRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQ 1768
Query: 145 E-KARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQF 203
+ K + EL+ + H E+ E ++L+ + + +KL + ++ E +LQE+
Sbjct: 1769 DLKIQEELRIAH-----MHLKEQQETIDKLRGIVSEKTDKLSNMQ-KDLENSNAKLQEKI 1822
Query: 204 DNLNA-AHETSKLEIEASHSEK----LELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQ 258
L A H+ L+ + + ++K +E LKK + + K EIE +L L E
Sbjct: 1823 QELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSK-LEIENLNLAQKLHENL 1881
Query: 259 ESLEKQIND----------LKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELES 308
E ++ + + LK E D L E L+ E + R + LK +++ E
Sbjct: 1882 EEMKSVMKERDNLRRVEETLKLERDQLKESLQ-ETKARDLEIQQELKTARMLSKEH---- 1936
Query: 309 LKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQL 368
K ++ EK+ ++ I++ ++K +D + + K + Q+ E R+ + + +S +
Sbjct: 1937 -KETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKK 1995
Query: 369 STEQAVLQESLEKESKVNKRLSMENEELLWKLH 401
E L++ E ++ + + M+N +L KLH
Sbjct: 1996 INEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLH 2028
Score = 60.1 bits (144), Expect = 4e-09
Identities = 73/321 (22%), Positives = 143/321 (44%), Gaps = 45/321 (14%)
Query: 107 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEK 166
Q LL+ +EE + K ++ E+ NL+ EL T E +E R EL ++ ++
Sbjct: 1141 QQLLNVQEEMSEMQKKIN-EIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSIT 1199
Query: 167 TERE--NRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEK 224
ER+ L++ + E + LR YI E E +Q +E+ L AH K H E
Sbjct: 1200 KERKVLKELQKSFETERDHLRG-YIREIEATGLQTKEE---LKIAHIHLK-----EHQET 1250
Query: 225 LELLKKAYEASLSEIKKGHEIEKKSLE-----DLLSEKQESLEKQINDLKSENDALNE-- 277
++ L+++ ++I ++EK + +L E+QE L + ++ + +NE
Sbjct: 1251 IDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELL-PNVKEVSETQETMNELE 1309
Query: 278 -------------KLKSEEQKRRAREKANLKNPQIMYLEQELESLKAV---LEIKNEKLH 321
+ E ++ R EK +I L +E ++LK + LE+K+++L
Sbjct: 1310 LLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLK 1369
Query: 322 QQDIKLMKMEKLVDNNTALVDKLKRFQQENE------ELKARMDKHMAISRQLSTEQAVL 375
+ + + K+ ++ + L +++NE E++ K A+ R + E L
Sbjct: 1370 EHIRE--TLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLR-IEIEMLGL 1426
Query: 376 QESLEKESKVNKRLSMENEEL 396
+ L++ K ++ E ++L
Sbjct: 1427 SKRLQESHDEMKSVAKEKDDL 1447
Score = 52.4 bits (124), Expect = 8e-07
Identities = 81/384 (21%), Positives = 177/384 (46%), Gaps = 52/384 (13%)
Query: 68 TLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ-- 125
T +L + TK + + + + ++LL E + + L + K TL++
Sbjct: 1268 TQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIE 1327
Query: 126 -ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQH-QAEKTEREN--RLKEFYTREY 181
E + L + + + L K R+ L+T+ EA +H Q ++ RE +++E +++
Sbjct: 1328 MERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE 1387
Query: 182 EKLR--------DTYIEEAEKYK------MQLQEQFDNLNAAHETSKLEIEASHSEK--L 225
+ L + E E++K ++++ + L+ + S E+++ EK L
Sbjct: 1388 QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL 1447
Query: 226 ELLKKAYEASLSEIKKG-HEIEKKSLED---------LLSEKQESL----------EKQI 265
+ L++ ++ ++K+ EI K LE L E++E++ E +I
Sbjct: 1448 QRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEI 1507
Query: 266 NDLKSENDALNEKLKSEEQK-RRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQD 324
+ ++ + +A+N+KL+++ Q+ E+ N+K QI +++++ LK E + K
Sbjct: 1508 STIQKQLEAINDKLQNKIQEIYEKEEQFNIK--QISEVQEKVNELKQFKEHRKAKDSALQ 1565
Query: 325 IKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQ-----AVLQESL 379
KM +L + ++++ +E EE+K R+ + + I R E A ++ES
Sbjct: 1566 SIESKMLELTNRLQESQEEIQIMIKEKEEMK-RVQEALQIERDQLKENTKEIVAKMKESQ 1624
Query: 380 EKESKVNKRLSM-ENEELLWKLHN 402
EKE + K ++ E +E + ++ +
Sbjct: 1625 EKEYQFLKMTAVNETQEKMCEIEH 1648
Score = 51.2 bits (121), Expect = 2e-06
Identities = 79/296 (26%), Positives = 137/296 (46%), Gaps = 44/296 (14%)
Query: 109 LLSEREEALK--QHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEK 166
LL E+E+ +K Q SQ+L N++ +L S + E +E + QT+++A A+
Sbjct: 583 LLREKEDQIKKLQEYIDSQKLENIKMDL---SYSLESIEDPKQMKQTLFDAETVALDAK- 638
Query: 167 TERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLE 226
RE LR +E EK K +L + + + + ++EA +++
Sbjct: 639 ------------RESAFLRSENLELKEKMK-ELATTYKQMENDIQLYQSQLEAKKKMQVD 685
Query: 227 LLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKR 286
L K+ A K I+ K +DLL + LE +I DL+ E LN+++ E+
Sbjct: 686 LEKELQSAFNEITKLTSLIDGKVPKDLLCNLE--LEGKITDLQKE---LNKEV---EENE 737
Query: 287 RAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKR 346
RE+ L + ++ L E+E L+ ++ K+E+LH I + +KL + +V K R
Sbjct: 738 ALREEVILLS-ELKSLPSEVERLRKEIQDKSEELH---IITSEKDKLF---SEVVHKESR 790
Query: 347 FQQENEEL-KARMDKHMAISRQLSTEQ-----AVLQESLEKESKV----NKRLSME 392
Q EE+ K + D S ST+Q L E++ K+ N+R++ E
Sbjct: 791 VQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQE 846
Score = 51.2 bits (121), Expect = 2e-06
Identities = 86/363 (23%), Positives = 154/363 (42%), Gaps = 62/363 (17%)
Query: 66 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVI---QHLLSEREEALKQHKT 122
EKT +L+ + EN + + + Q L + L + Q +SE E+ KQ K
Sbjct: 1799 EKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKD 1858
Query: 123 LSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYE 182
S L L E + + +KL + E+++V + + E+T + R + + +
Sbjct: 1859 QSLTLSKLEIENLNLA---QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQET 1915
Query: 183 KLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEK---LELLKKAYEASLSEI 239
K RD I++ K L ++ H+ + ++ SEK + ++K + S E+
Sbjct: 1916 KARDLEIQQELKTARMLSKE-------HKETVDKLREKISEKTIQISDIQKDLDKSKDEL 1968
Query: 240 -KKGHEIEKKSLEDL-------LSEKQ----ESLEKQ-------INDLKSENDALNEKL- 279
KK E++KK L+ L +S K+ E L+KQ + ++ +N L +KL
Sbjct: 1969 QKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLH 2028
Query: 280 ----------KSEEQKRRAREKANLKNPQ-IMYLEQELESLKAVLEIKNEKLHQQDIKLM 328
K ++ RR +E ++ Q I L + + + ++K EK D +
Sbjct: 2029 ESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQH 2088
Query: 329 KMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKR 388
E L + + + + LKR+ + MD H +LS + LEKE + K
Sbjct: 2089 LTESLREKCSRIKELLKRYSE--------MDDHYECLNRLSLD-------LEKEIEFQKE 2133
Query: 389 LSM 391
LSM
Sbjct: 2134 LSM 2136
Score = 48.9 bits (115), Expect = 9e-06
Identities = 75/351 (21%), Positives = 147/351 (41%), Gaps = 41/351 (11%)
Query: 98 KFEALTVVIQHLLSEREEALKQHKTLS-QELVNLRGELVTASTTCEKLEKARNELQTVYE 156
K + L + IQHL + + ++ + L + ++L E + + + + E Q V
Sbjct: 2204 KQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVL- 2262
Query: 157 AFVQQHQAEKTERENRLKEFYTREY--EKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSK 214
+ + E L+E+ + EKL++ +E ++ Q+ F+N A
Sbjct: 2263 -------SNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRI-CQVNNFFNNRIIAIMNES 2314
Query: 215 LEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSEN-- 272
E E E+ + K +E L +K+ +E K+ + L + Q+N +N
Sbjct: 2315 TEFE----ERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGA--QVNPTTQDNKN 2368
Query: 273 --------DALNEKLKS-EEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQ 323
EK++ E A+E A K +I+ +++ELE ++ K+H+
Sbjct: 2369 PHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHES 2428
Query: 324 DIKLMKMEKLVDNNTALVDKL----KRFQQENEELKARMDK----HMAISRQLSTEQAVL 375
+ L K ++ + L DK+ K +++E E+LK ++ K M +++ E +
Sbjct: 2429 NKCLEKTKETIQ---VLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISAT 2485
Query: 376 QESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSG 426
+ ++E + +V RL EN + + + S P S PL SG
Sbjct: 2486 KATVEYQKEV-IRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSG 2535
Score = 48.5 bits (114), Expect = 1e-05
Identities = 83/364 (22%), Positives = 170/364 (46%), Gaps = 57/364 (15%)
Query: 67 KTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQE 126
KT EL + + + + + QLK+ L ++ + + + + ++ L++ KTL+QE
Sbjct: 871 KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQE 930
Query: 127 LVNL----------RGELV-----TASTTCEKLEKARNELQTVYEAFVQQHQAEKTEREN 171
+L R +L T + + E+ RN L++ ++QHQ E N
Sbjct: 931 KDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALES-----LKQHQ----ETIN 981
Query: 172 RLKEFYTREYEKLRDTYIEE-AEKYKMQLQEQFDNLN-----AAHETSKLEIEASHSEKL 225
LK + E R+ ++EE + K + Q++ ++ A T L + +E +
Sbjct: 982 TLKSKISEEVS--RNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII 1039
Query: 226 ELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQ-------ESLEKQINDLKSENDALNEK 278
E +K + S I++ +E++ + LE +++EK+ E++E I + + E L ++
Sbjct: 1040 EQQRKIF----SLIQEKNELQ-QMLESVIAEKEQLKTDLKENIEMTIEN-QEELRLLGDE 1093
Query: 279 LKSEEQKRRAREK--ANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDN 336
LK ++Q+ A+EK A K ++ L ++ L+ K+++L ++ +L+ +++ +
Sbjct: 1094 LK-KQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSE 1152
Query: 337 NTALVDKLKRFQQE--NEELKARMDKHMAISR----QLSTEQAVLQESLEKESKVNKRLS 390
+++++ + E N+EL +HM R Q E +S+ KE KV K L
Sbjct: 1153 MQKKINEIENLKNELKNKELTL---EHMETERLELAQKLNENYEEVKSITKERKVLKELQ 1209
Query: 391 MENE 394
E
Sbjct: 1210 KSFE 1213
Score = 45.4 bits (106), Expect = 1e-04
Identities = 73/328 (22%), Positives = 136/328 (41%), Gaps = 47/328 (14%)
Query: 142 EKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREY----EKLRD--TYIEEAEKY 195
EK EK QT+ + Q T ++N+ +R EK+R+ + EA++
Sbjct: 2337 EKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKES 2396
Query: 196 KMQLQEQFDNLNAAHETS-----KLEIEASHSEK-LELLKKAYEASLSEIKKGHEIEKKS 249
M + + + E + KL+ + S K LE K+ + ++ G + K+
Sbjct: 2397 AMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEE 2456
Query: 250 LEDLLSEKQE-SLEKQINDLKSENDALNEKLKSEEQKRRARE-KANLKNPQIMYLEQELE 307
+EDL + + LEK N + E + K E QK R + NL+ Q+ +
Sbjct: 2457 IEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRR------SQQAQ 2510
Query: 308 SLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDK---------LKRFQQENEELKARM 358
+ E + + + + +V N AL+ K + + +Q+NE+L +
Sbjct: 2511 DTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQK 2570
Query: 359 DKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSS--- 415
++ ++ ++ LS E +E K + +K+++ EN K+ S K+ T S
Sbjct: 2571 NELLSNNQHLSNEVKTWKERTLKR-EAHKQVTCENSPKSPKVTG--TASKKKQITPSQCK 2627
Query: 416 ------AIPLQSPRN------SGSFPSP 431
+P +SP++ S S PSP
Sbjct: 2628 ERNLQDPVPKESPKSCFFDSRSKSLPSP 2655
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 76.6 bits (187), Expect = 4e-14
Identities = 83/351 (23%), Positives = 161/351 (45%), Gaps = 41/351 (11%)
Query: 106 IQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAE 165
I+ LL +EE K+ L E+V LR L + ++ E+++ E + F Q+ Q
Sbjct: 148 IRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQR 207
Query: 166 KTE--RENRLKEFYTREYEKLR-------------DTYIEEAEKYKMQLQEQFDNLNAAH 210
+ E RE R KE +E ++++ Y++++++ +L++Q +
Sbjct: 208 QNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILN 267
Query: 211 ETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEK---QIND 267
E + E+E +L ++ + SL + E ++K+LE L K+E + + I
Sbjct: 268 ERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALE--LKAKEEEVHQMRLDIGK 325
Query: 268 LKSENDALNEKL-KSEEQKRRARE-KANLKNPQIMYLEQELESLKAVLEI----KNEKLH 321
L + +++KL +E+QK + K LKN QI+ LE+E+E+ K E+ +E L
Sbjct: 326 LNKIREQIHKKLHHTEDQKAEVEQHKETLKN-QIVGLEREVEASKKQAELDRKAMDELLR 384
Query: 322 QQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEK 381
++DI M K V+ D +K +Q L+ + + + + +Q + LEK
Sbjct: 385 ERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNY----KDEAQKQRKIIFHLEK 440
Query: 382 E--------SKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRN 424
E S + +++ M E++ K+ + ++ S I L+ +N
Sbjct: 441 ERDRYINQASDLTQKVLMNMEDI--KVRETQIFDYRKKIAESEIKLKQQQN 489
Score = 45.4 bits (106), Expect = 1e-04
Identities = 55/297 (18%), Positives = 129/297 (43%), Gaps = 51/297 (17%)
Query: 145 EKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFD 204
E A E++ ++ + + +K+ + R++ Y R + ++ +Y + EK M + +
Sbjct: 13 ESAFEEMERDFQGVLHELSGDKSLEKFRIE--YERLHAVMKKSY--DNEKRLMAKCRELN 68
Query: 205 N---LNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESL 261
+N+A + L++ + LKK E + + ++ E+K+ E +L+ K+E +
Sbjct: 69 AEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIV 128
Query: 262 E----------------KQINDL--------KSENDALNEKLK--------SEEQKRRAR 289
I DL K + L+E +K +E+Q+ R
Sbjct: 129 NLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETER 188
Query: 290 EKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQ 349
K ++ I +QE++ + + K + + +L +++ +D+ + L+++ Q
Sbjct: 189 SKEEAEHA-ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQ 247
Query: 350 ENEELKARMDKHMAISR-----------QLSTEQAVLQESLEKESKVNKRLSMENEE 395
+++E ++++ + + Q A LQ+ E+ S V ++LS EN++
Sbjct: 248 KSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQ 304
Score = 40.4 bits (93), Expect = 0.003
Identities = 57/263 (21%), Positives = 104/263 (39%), Gaps = 34/263 (12%)
Query: 106 IQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAE 165
+ ++SER+ Q + EL L ++ + K E N Q + + + + + +
Sbjct: 603 LDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYN--QRLEDMRILRLEIK 660
Query: 166 KTERENRLKEFYTREYEKLRDTYIEEAEKYKMQ------LQEQFDNLNAAHETSKLEIEA 219
K RE + E+LR + + + L+E+ +N H KLE A
Sbjct: 661 KLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLE--A 718
Query: 220 SHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKL 279
S EL++K + I K E+ +K L LL EK EKL
Sbjct: 719 SDPNAYELIQKIHTLQKRLISKTEEVVEKEL--LLQEK-------------------EKL 757
Query: 280 KSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTA 339
E + AR+ Q+ + L K L++ + +L+ +++ + + V+ T
Sbjct: 758 YMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTN 817
Query: 340 LVDKLKR---FQQENEELKARMD 359
+ LK+ Q+ E+L+ D
Sbjct: 818 ELQNLKKKYLAQKRKEQLQKNKD 840
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 75.1 bits (183), Expect = 1e-13
Identities = 85/386 (22%), Positives = 177/386 (45%), Gaps = 46/386 (11%)
Query: 37 VFHTVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGN 96
V T KS N + C + E L + K + ++ IL L +
Sbjct: 885 VSQTCSKSEIHNEKEKCFIKEH-------ENLKPLLEQKELRDRRAELILLKDSLAKSPS 937
Query: 97 TKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYE 156
K + L+ V + L E+ E L++ +E +N + +LV E L+ +R E QTV E
Sbjct: 938 VKNDPLSSVKE--LEEKIENLEKECKEKEEKIN-KIKLVAVKAKKE-LDSSRKETQTVKE 993
Query: 157 AFVQQHQAEKTERENRLKEFY--TREYEKLRDTYIEEAEKYKMQ------LQEQFDNLNA 208
++ ++EK + +++ Y+ L Y +++E+ ++ + + ++L
Sbjct: 994 E-LESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTR 1052
Query: 209 AHETSKLEIEASHSEKLELLK---------KAYEASLSEIKKGHEIEKKSLEDLLSEKQE 259
S L+ E +S+ +LL K E + E+++ + K LE +K++
Sbjct: 1053 QLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQ 1112
Query: 260 SLEKQ---INDLKS-------ENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESL 309
+++ +N+L+ E L + ++ E ++ ++ L N +I E+ ++ L
Sbjct: 1113 KIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKEL 1172
Query: 310 KAVLEIKNEKLH--QQDIKLMKM--EKLVDNNTALVDKLKRFQQENEELK---ARMDKHM 362
L KN K+ +Q+IK+ K E L + T+L +++++++N ++K + K +
Sbjct: 1173 NQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKEL 1232
Query: 363 AISRQLSTEQAVLQESLEKESKVNKR 388
A S+Q T+ +LQ SL+ E + +++
Sbjct: 1233 ADSKQAETDHLILQASLKGELEASQQ 1258
Score = 67.4 bits (163), Expect = 2e-11
Identities = 84/381 (22%), Positives = 167/381 (43%), Gaps = 61/381 (16%)
Query: 73 QYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKT---LSQELVN 129
++++ + Q+ + +L+Q L T+ +AL + L E E+ L Q + L + N
Sbjct: 504 EFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKN 563
Query: 130 LRGE-------LVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYE 182
L+ + L T ++LE N L + F+ + + E +N K+ E
Sbjct: 564 LQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERL 623
Query: 183 KLR-DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLE-------LLKKAYEA 234
L +E+ +Y +L+++ + L E + L+ + + +KLE +L + E
Sbjct: 624 ILELGKKVEQTIQYNSELEQKVNELTGGLEET-LKEKDQNDQKLEKLMVQMKVLSEDKEV 682
Query: 235 SLSEIKKGHEIEKK----------SLEDLLSEKQE--------SLEKQINDLKSENDALN 276
+E+K +E K LE LS+K++ LEK++ + E D LN
Sbjct: 683 LSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLN 742
Query: 277 EKLKSEEQKR----------------RAREKANLKNPQIMYLEQELESLKAVLEIKNEKL 320
+ L++E+ ++ E + K+ + L+ ESL + E K
Sbjct: 743 KLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKD-VVNVLQAVGESLAKINEEKCNLA 801
Query: 321 HQQDIKLMKMEK----LVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQ 376
Q+D K++++EK L + + ++LK ++ E+ K + K + ++ +E+ LQ
Sbjct: 802 FQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKEL---EEIQSEKEALQ 858
Query: 377 ESLEKESKVNKRLSMENEELL 397
L + N++ +EN+ LL
Sbjct: 859 SDLLEMKNANEKTRLENQNLL 879
Score = 63.9 bits (154), Expect = 3e-10
Identities = 84/370 (22%), Positives = 166/370 (44%), Gaps = 42/370 (11%)
Query: 51 SLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLL 110
S+ +Q T + + EK L + E+Q + ++ N K + L + QH+
Sbjct: 317 SILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKD--EVTYMNNLKLK-LEMDAQHI- 372
Query: 111 SEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAF---VQQHQAEKT 167
++E + + L ++ L L C +EK ++EL + + F V+QH E
Sbjct: 373 --KDEFFHEREDLEFKINELL--LAKEEQGCV-IEKLKSELAGLNKQFCYTVEQHNREVQ 427
Query: 168 ERENRLKEFYTREYEKLRDTYIEEAEKYKMQ-------LQEQFDNLNAAHETSKLEIEAS 220
LKE + +E +L +T++ ++EK K+ L+EQ +NL + + L E S
Sbjct: 428 S----LKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYE-S 482
Query: 221 HSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNE--- 277
E +E+L+ S +I + E +S++ + L++++ +E DAL E
Sbjct: 483 LREIMEILQTELGESAGKISQ----EFESMKQQQASDVHELQQKLRTAFTEKDALLETVN 538
Query: 278 KLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKME----KL 333
+L+ E +K ++++ + LE +++L+ + L Q+D L ++E L
Sbjct: 539 RLQGENEKLLSQQEL------VPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSL 592
Query: 334 VDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTE-QAVLQESLEKESKVNKRLSME 392
+ ++KLK +E + + ++ + +L + + +Q + E E KVN+
Sbjct: 593 TEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGL 652
Query: 393 NEELLWKLHN 402
E L K N
Sbjct: 653 EETLKEKDQN 662
Score = 60.5 bits (145), Expect = 3e-09
Identities = 82/371 (22%), Positives = 154/371 (41%), Gaps = 63/371 (16%)
Query: 70 ELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVN 129
E+ + KCE + IL+L + + L + L EE LK+ Q+L
Sbjct: 609 EMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEK 668
Query: 130 LRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYI 189
L +V E E E++++YE + +EK + L+ F +++ + + +I
Sbjct: 669 L---MVQMKVLSEDKEVLSAEVKSLYEEN-NKLSSEKKQLSRDLEVFLSQKEDVILKEHI 724
Query: 190 EEAEKYKMQLQEQFDNLNAAHETSKLE-------------------IEASHSEKLELLKK 230
+ EK + E+ DNLN E +++ E S + + + +
Sbjct: 725 TQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQ 784
Query: 231 AYEASLSEI------------KKGHEIEKK-------------SLEDLLSEKQES---LE 262
A SL++I +K E+EK+ L+ LL + ++ L
Sbjct: 785 AVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLR 844
Query: 263 KQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNE---- 318
K++ +++SE +AL L + + A EK L+N ++ +E+ + EI NE
Sbjct: 845 KELEEIQSEKEALQSDLL---EMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKC 901
Query: 319 --KLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQ 376
K H+ L++ ++L D L+ LK ++ +K D ++ + + +
Sbjct: 902 FIKEHENLKPLLEQKELRDRRAELI-LLKDSLAKSPSVK--NDPLSSVKELEEKIENLEK 958
Query: 377 ESLEKESKVNK 387
E EKE K+NK
Sbjct: 959 ECKEKEEKINK 969
Score = 54.3 bits (129), Expect = 2e-07
Identities = 83/353 (23%), Positives = 153/353 (43%), Gaps = 46/353 (13%)
Query: 79 ENQSGFILQLKQLLACGNTKFEALTVVIQH---LLSEREEALKQHKTLSQ--------EL 127
E Q I +LK LA N +F V QH + S +E+ K+ L++ E
Sbjct: 395 EEQGCVIEKLKSELAGLNKQF--CYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEK 452
Query: 128 VNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDT 187
+ L E+ CE L++ + E YE+ + + +TE + ++E+E ++
Sbjct: 453 LTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKI-SQEFESMKQQ 511
Query: 188 YIEEAEKYKMQLQEQFDNLNAAHET-SKLEIEASHSEKLELLKKAYEASLSEIKKGHEIE 246
+ + + +L+ F +A ET ++L+ E + L E ++ +++ + +
Sbjct: 512 QASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVY 571
Query: 247 KKSLEDLLSEKQESLEKQINDLKSENDALNEKLKS------------EEQKRRAREKANL 294
SL + +E LE +IN L E D KLK+ E ++R E
Sbjct: 572 LLSLSQRDTMLKE-LEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKK 630
Query: 295 KNPQIMY---LEQELESLKAVLEIKNEKLHQQDIKLMKMEKLV-------DNNTALVDKL 344
I Y LEQ++ L LE E L ++D K+EKL+ ++ L ++
Sbjct: 631 VEQTIQYNSELEQKVNELTGGLE---ETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEV 687
Query: 345 KRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKE--SKVNKRLSMENEE 395
K +EN +L + + +SR L + ++ + KE +++ K+L + EE
Sbjct: 688 KSLYEENNKLSSEKKQ---LSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEE 737
Score = 49.3 bits (116), Expect = 7e-06
Identities = 78/367 (21%), Positives = 153/367 (41%), Gaps = 65/367 (17%)
Query: 100 EALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFV 159
+ALT + LL E+ E +Q +L +E + ++ E+ + T K+ A EL+ + +V
Sbjct: 72 KALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVT---KMGDAHKELEQSHINYV 128
Query: 160 QQHQAEKTE------RENRLKEFYTREYEKLRDTYIEEAEKYKMQ---------LQEQFD 204
++ + K E + + K ++ E+ +T +E +E+ K Q LQE+ +
Sbjct: 129 KEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIE 188
Query: 205 NLNAAHETSKL----EIEASHSEKLELLKK-----------------AYEASLSEIKKGH 243
+ E L +++A+ EK E + + + + L ++K H
Sbjct: 189 KIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIH 248
Query: 244 EIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQK------------RRAREK 291
+ E K L + + E +IN L + L ++ ++ E+ R+A
Sbjct: 249 QEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSN 308
Query: 292 ANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLK-RFQQE 350
AN N L QE ++ V+ K + L +L ++ + ++ LK + + +
Sbjct: 309 ANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMD 368
Query: 351 NEELK-----ARMDKHMAISRQL--STEQAVLQESLEKE-SKVNKRLSMENEELLWKLHN 402
+ +K R D I+ L EQ + E L+ E + +NK+ E+ HN
Sbjct: 369 AQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQ-----HN 423
Query: 403 GDLCSPK 409
++ S K
Sbjct: 424 REVQSLK 430
Score = 45.1 bits (105), Expect = 1e-04
Identities = 72/326 (22%), Positives = 129/326 (39%), Gaps = 39/326 (11%)
Query: 96 NTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCE----KLEKARNEL 151
NTK + L V + L++ ++A H L +L+GEL + E +L + +E
Sbjct: 1218 NTKIKQLLVKTKKELADSKQAETDHLILQ---ASLKGELEASQQQVEVYKIQLAEITSEK 1274
Query: 152 QTVYEAF---VQQHQAEKTERENRLKEFYT--REYEKLRDTYIEEAEKYKMQ----LQEQ 202
++E +QHQ + + R+ R + + T E E YK++ L++Q
Sbjct: 1275 HKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQ 1334
Query: 203 FDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLE 262
+ + ET + E H LE+L + L + + +I L+ L SE LE
Sbjct: 1335 KNKSMSQAETEGAKQEREH---LEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLE 1391
Query: 263 ---KQINDLKSENDALNEKL----------KSEEQK---RRAREKANLKN---PQIMYLE 303
K + + S+ L EKL KSE + + + L+N Q+ +L+
Sbjct: 1392 RHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQ 1451
Query: 304 QELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMA 363
+E L+ + K+ Q +L K E + + LK ++ +D H
Sbjct: 1452 EEHRKTVETLQQQLSKMEAQLFQL-KNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTV 1510
Query: 364 ISRQLSTEQAVLQESLEKESKVNKRL 389
+ + ES+ S + L
Sbjct: 1511 TREEGEGMETTDTESVSSASTYTQSL 1536
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 73.9 bits (180), Expect = 3e-13
Identities = 55/299 (18%), Positives = 146/299 (48%), Gaps = 19/299 (6%)
Query: 107 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEK 166
+ ++ E+EE +++ + + E L EK EK R + ++E + Q EK
Sbjct: 341 EEMMWEKEEKMRRQEEMMWEKEEKMRRL--EEMMWEKEEKIRELEEKMHEQEKIREQEEK 398
Query: 167 TERENRLKEFYTREYEKLR-----DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASH 221
+ E +++E R+ ++ + + E+ EK + Q ++ + HE K+ E
Sbjct: 399 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR 458
Query: 222 SEKLELLKKAYEASLSEIKKGHEI----EKKSLEDLLSEKQESLEKQINDLKSENDALNE 277
E+ E+ ++ +I++ EI EK ++ + +++E + +Q + + + + E
Sbjct: 459 QEQEEMWRQE-----EKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIRE 513
Query: 278 KLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNN 337
+ EE+ R EK + +I E+++ + +++ + EK+ +Q+ K+ + EK+
Sbjct: 514 Q---EEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQE 570
Query: 338 TALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 396
+ ++ ++ +++ E+++ + +K ++ ++ ++QE EK + +++ + E++
Sbjct: 571 EKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 629
Score = 68.2 bits (165), Expect = 1e-11
Identities = 65/296 (21%), Positives = 135/296 (45%), Gaps = 21/296 (7%)
Query: 110 LSEREEALKQH--KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKT 167
+ E+EE +++ K QE R E EK EK R + + ++E + + E+
Sbjct: 316 IQEQEEKIREQEEKIREQEEKMRRQE----EMMWEKEEKMRRQEEMMWEKEEKMRRLEEM 371
Query: 168 --ERENRLKEFYTR--EYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSE 223
E+E +++E + E EK+R+ + E+ K++ QE+ A + +I +
Sbjct: 372 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 431
Query: 224 KLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEE 283
E KK + +K HE EK E+ E QE + +Q ++ + + +K K E
Sbjct: 432 IREQEKKMWRQE----EKIHEQEKIREEEKRQE-QEEMWRQEEKIREQEEIWRQKEKMHE 486
Query: 284 QKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDK 343
Q EK + ++ E+++ + + + EK+ +Q+ K+ + E+ + + +
Sbjct: 487 Q-----EKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIRE 541
Query: 344 LKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWK 399
+ QE EE ++ M ++ ++ ++E EK + +++ E EE +W+
Sbjct: 542 QEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKI-REQEEKIWE 596
Score = 60.1 bits (144), Expect = 4e-09
Identities = 65/306 (21%), Positives = 142/306 (46%), Gaps = 27/306 (8%)
Query: 106 IQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAE 165
+Q + SE+ E K L ++L + L E + ELQ+V Q Q E
Sbjct: 230 LQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEA-DHLGKELQSVSAKL--QAQVE 286
Query: 166 KTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKL 225
+ E NRL + + E+ E+ ++++ ++QEQ + + E + + E ++
Sbjct: 287 ENELWNRLNQ----QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEE 342
Query: 226 ELLKKAYEASLSEIKKGHEIEK-KSLEDLLSEKQESLEKQINDLKSENDAL--NEKLKSE 282
+ +K + E + EK + LE+++ EK+E + +++ + E + + E+ + E
Sbjct: 343 MMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKI-RELEEKMHEQEKIREQEEKRQE 401
Query: 283 EQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVD 342
E+K R +EK + ++ E+++ + EK+ +Q+ K+ + E+ + + +
Sbjct: 402 EEKIREQEKRQEQEAKMWRQEEKIRE-------QEEKIREQEKKMWRQEEKIHEQEKIRE 454
Query: 343 KLKRFQQE---NEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLS------MEN 393
+ KR +QE +E K R + + ++ EQ +++ EK + +++ E
Sbjct: 455 EEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQ 514
Query: 394 EELLWK 399
EE +W+
Sbjct: 515 EEKMWR 520
Score = 28.9 bits (63), Expect = 9.6
Identities = 19/82 (23%), Positives = 37/82 (45%)
Query: 342 DKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLH 401
D+ K Q E L+ ++ + R L+ ++ LQ +L K+L E +L+ +LH
Sbjct: 109 DEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH 168
Query: 402 NGDLCSPKRSPTSSAIPLQSPR 423
+ + + SA+ Q +
Sbjct: 169 DSWKFAGELEQALSAVATQKKK 190
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 73.2 bits (178), Expect = 4e-13
Identities = 78/302 (25%), Positives = 135/302 (44%), Gaps = 39/302 (12%)
Query: 107 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEK 166
+ L+ RE+ L L+ E+ L+ +L+ ++ +A EL E + A+K
Sbjct: 852 EELVKVREKQLAAENRLT-EMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKK 910
Query: 167 TERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLE 226
E E + R E+ +AEK KMQ N+ E +LE E S +KL+
Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEKKKMQ-----QNIQELEE--QLEEEESARQKLQ 963
Query: 227 LLKKAYEASLSEIKKGHEI----------EKKSLEDLLSE------KQESLEKQINDLKS 270
L K EA L ++++ I EKK LED ++E ++E K + LK+
Sbjct: 964 LEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKN 1023
Query: 271 ENDA----LNEKLKSEEQKRRAREKANLK--------NPQIMYLEQELESLKAVLEIKNE 318
+++A L E+L+ EE++R+ EK K + QI L+ ++ LK L K E
Sbjct: 1024 KHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE 1083
Query: 319 KLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQES 378
+L L ++E+ + K++ + + EL+ ++ A + ++ L E
Sbjct: 1084 EL---QAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEE 1140
Query: 379 LE 380
LE
Sbjct: 1141 LE 1142
Score = 66.2 bits (160), Expect = 5e-11
Identities = 62/289 (21%), Positives = 131/289 (45%), Gaps = 23/289 (7%)
Query: 114 EEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRL 173
++ L + KT+S + R + EK KA + + + EA Q+ + E+ ++ R
Sbjct: 1447 DQLLAEEKTISAKYAEERDRAEAEAR--EKETKALSLARALEEAMEQKAELERLNKQFRT 1504
Query: 174 KEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYE 233
+ + + E EK K L++Q + + E + E++A+ KL L E
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRL-----E 1559
Query: 234 ASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKAN 293
+L +K E + + ++ EK++ L +Q+ ++++E + +E+K+R+ A
Sbjct: 1560 VNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELE--------DERKQRSMAVAA 1611
Query: 294 LKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEE 353
K LE +L+ L+A ++ N+ +D + ++ KL + +L + EE
Sbjct: 1612 RKK-----LEMDLKDLEAHIDSANKN---RDEAIKQLRKLQAQMKDCMRELDDTRASREE 1663
Query: 354 LKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHN 402
+ A+ ++ + + E LQE L + ++ E +EL ++ N
Sbjct: 1664 ILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN 1712
Score = 65.5 bits (158), Expect = 9e-11
Identities = 74/309 (23%), Positives = 134/309 (43%), Gaps = 22/309 (7%)
Query: 85 ILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKL 144
I +LK LA + +A ++ +++ ALK+ + L ++ L+ +L + + K
Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKA 1130
Query: 145 EKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFD 204
EK + +L EA KTE E+ L T ++LR +E K L+E+
Sbjct: 1131 EKQKRDLGEELEAL-------KTELEDTLDS--TAAQQELRSKREQEVNILKKTLEEE-- 1179
Query: 205 NLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQ 264
HE E+ HS+ +E L + E + +K E K++LE +E+ E +
Sbjct: 1180 --AKTHEAQIQEMRQKHSQAVEELAEQLEQT-KRVKANLEKAKQTLE---NERGELANEV 1233
Query: 265 INDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQD 324
L+ + D+ +++ K E Q + + K N L ++ L+ L+ L Q D
Sbjct: 1234 KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSD 1293
Query: 325 IKLMKMEK-LVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKES 383
K K+ K + L D + Q+EN + + K +Q+ E+ +E LE+E
Sbjct: 1294 SKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTK----LKQVEDEKNSFREQLEEEE 1349
Query: 384 KVNKRLSME 392
+ L +
Sbjct: 1350 EAKHNLEKQ 1358
Score = 59.3 bits (142), Expect = 7e-09
Identities = 67/316 (21%), Positives = 137/316 (43%), Gaps = 36/316 (11%)
Query: 114 EEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRL 173
EEA++Q L + R E+ ++ + + K+ +EL+ A QQ + KT+ E
Sbjct: 1486 EEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELE 1545
Query: 174 KEFYTREYEKLR----------------DTYIEEAEKYKMQLQEQFDNLNAAHETSKLE- 216
E E KLR E++E+ K QL Q + A E + +
Sbjct: 1546 DELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQR 1605
Query: 217 -IEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDAL 275
+ + +KLE+ K EA + K + K L L ++ ++ + ++++D ++ + +
Sbjct: 1606 SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCM-RELDDTRASREEI 1664
Query: 276 NEKLKSEEQKRRAREKANLKNPQIMYLEQEL---ESLKAVLEIKNEKLHQQ--------D 324
+ K E+K ++ E +++ L++EL E K + + ++L +
Sbjct: 1665 LAQAKENEKKLKSME------AEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1718
Query: 325 IKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESK 384
+ L + +L L ++L+ Q E + R+ K Q++T+ + + +K
Sbjct: 1719 LALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNEN 1778
Query: 385 VNKRLSMENEELLWKL 400
++L +N+EL KL
Sbjct: 1779 ARQQLERQNKELKVKL 1794
Score = 55.8 bits (133), Expect = 7e-08
Identities = 78/363 (21%), Positives = 160/363 (44%), Gaps = 35/363 (9%)
Query: 41 VEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTK--CENQSGFILQLKQLLACGNT- 97
+++ RQK+ +++ + + L K ++ K K EN+ G + ++L G
Sbjct: 1187 IQEMRQKHSQAV----EELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGD 1242
Query: 98 ---KFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTV 154
K + + +Q L + E + L+ ++ L+ EL + + + ++L
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302
Query: 155 YEAFVQQHQ--AEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHET 212
+ A Q Q E + ENR K + + +++ D E ++ QL+E+ + A H
Sbjct: 1303 FSALESQLQDTQELLQEENRQKLSLSTKLKQVED----EKNSFREQLEEEEE---AKHNL 1355
Query: 213 SKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDL--LSEKQE-------SLEK 263
K +I H++ + +KK E S+ ++ E+++K +DL LS++ E LEK
Sbjct: 1356 EK-QIATLHAQVAD-MKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413
Query: 264 QINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNE-KLHQ 322
L+ E D L L + Q EK K Q++ E+ + + A + E + +
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE 1473
Query: 323 QDIKLMK----MEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQES 378
++ K + +E+ ++ L K+F+ E E+L + D +L + L++
Sbjct: 1474 KETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533
Query: 379 LEK 381
+E+
Sbjct: 1534 VEE 1536
Score = 54.3 bits (129), Expect = 2e-07
Identities = 65/301 (21%), Positives = 134/301 (44%), Gaps = 39/301 (12%)
Query: 111 SEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQ------HQA 164
+ REE L Q K ++L ++ E++ E+A+ + Q + + A
Sbjct: 1659 ASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1718
Query: 165 EKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEK 224
E + RL+ + E+L + E+ + + + NL + L +E SH++K
Sbjct: 1719 LALEEKRRLEARIAQLEEELEE---EQGNTELINDRLKKANLQIDQINTDLNLERSHAQK 1775
Query: 225 LELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQ 284
E ++ E E+K ++ + +E + K ++ I L+++ L E+L +E +
Sbjct: 1776 NENARQQLERQNKELK----VKLQEMEGTVKSKYKA---SITALEAKIAQLEEQLDNETK 1828
Query: 285 KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKL 344
+R+A K Q+ E++L+ + +L++ +E+ + + K D +L
Sbjct: 1829 ERQAACK------QVRRTEKKLKDV--LLQVDDERRNAEQYK--------DQADKASTRL 1872
Query: 345 KRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGD 404
K+ +++ EE + + A R+L E L+++ E +N+ +S L KL GD
Sbjct: 1873 KQLKRQLEEAEEEAQRANASRRKLQRE---LEDATETADAMNREVS----SLKNKLRRGD 1925
Query: 405 L 405
L
Sbjct: 1926 L 1926
Score = 53.5 bits (127), Expect = 4e-07
Identities = 61/282 (21%), Positives = 121/282 (42%), Gaps = 19/282 (6%)
Query: 107 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEK 166
+ +L++ +E K+ K++ E++ L+ EL A + ++ R+EL A A
Sbjct: 1662 EEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI-ANSSGKGALA 1720
Query: 167 TERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLE 226
E + RL+ + E+L + E+ + + + NL + L +E SH++K E
Sbjct: 1721 LEEKRRLEARIAQLEEELEE---EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNE 1777
Query: 227 LLKKAYEASLSEIK-KGHEIEK------KSLEDLLSEKQESLEKQINDLKSENDALNEKL 279
++ E E+K K E+E K+ L K LE+Q+++ E A +++
Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV 1837
Query: 280 KSEEQKRR--------AREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKME 331
+ E+K + R A Q L+ LK LE E+ + + K++
Sbjct: 1838 RRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1897
Query: 332 KLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQA 373
+ +++ T D + R + R D + R+++ + A
Sbjct: 1898 RELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGA 1939
Score = 30.0 bits (66), Expect = 4.3
Identities = 33/127 (25%), Positives = 60/127 (47%), Gaps = 18/127 (14%)
Query: 277 EKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDN 336
E + EE+ + REK ++ E+E+L++ ++ EKL Q+ +L +L
Sbjct: 846 EMMAKEEELVKVREKQLAAENRLT----EMETLQS--QLMAEKLQLQE-QLQAETELCAE 898
Query: 337 NTALVDKLKRFQQENEE----LKARMDKHMAISRQLSTEQAVLQ-------ESLEKESKV 385
L +L +QE EE L+AR+++ + L E+ +Q E LE+E
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958
Query: 386 NKRLSME 392
++L +E
Sbjct: 959 RQKLQLE 965
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 73.2 bits (178), Expect = 4e-13
Identities = 75/322 (23%), Positives = 136/322 (42%), Gaps = 31/322 (9%)
Query: 66 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ 125
+KT ++ + Q+G I LK +L K L I++L + + KQ +L +
Sbjct: 540 KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE 599
Query: 126 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 185
+ +L+ + T LE+A E + E +Q ++ E++
Sbjct: 600 RVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQ--------------- 644
Query: 186 DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEI 245
EE + YK L++ + S L+ + S E L K + +SL+ +
Sbjct: 645 ----EEIDNYKKDLKD------LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS 694
Query: 246 EKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRR----AREKANLKNPQIMY 301
K+LE L +K+E K + LK ++A E S E R RE K+
Sbjct: 695 RLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKA 754
Query: 302 LEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARM-DK 360
+ L+ + E++NEK + +D K+ ++E+ V + V LK +Q ++ A+M ++
Sbjct: 755 QAEVDRLLEILKEVENEK-NDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEE 813
Query: 361 HMAISRQLSTEQAVLQESLEKE 382
L+ LQ+SL K+
Sbjct: 814 ARRREDNLNDSSQQLQDSLRKK 835
Score = 48.1 bits (113), Expect = 2e-05
Identities = 84/372 (22%), Positives = 160/372 (43%), Gaps = 78/372 (20%)
Query: 105 VIQHLLSEREEAL---KQH-KTLSQELVNLRGELVTASTTCEKLE----KARNELQTVYE 156
++Q LSE+E +L K+H +L+ + L T E+ + K ++L+ +E
Sbjct: 663 LLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHE 722
Query: 157 AFVQQHQA-EKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKL 215
A ++ + E ++R L+ TR Y +E+ K + ++ + L E K
Sbjct: 723 AALEARASPEMSDRIQHLEREITR--------YKDESSKAQAEVDRLLEILKEV-ENEKN 773
Query: 216 EIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEK--------------QESL 261
+ + +E LE K ++ +K ++EKK +L E Q+SL
Sbjct: 774 DKDKKIAE-LERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSL 832
Query: 262 EKQINDLKSENDALNEKLK--SEEQKRRAREKANLKNPQ------IMYLE---QELESLK 310
K+ + ++ +AL E ++ +E + A+E++ N + +M +E QELES+K
Sbjct: 833 RKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMK 892
Query: 311 AVLEIKNEKL----------------HQQDIKLMKMEKLV------DNNTALVDKLKRFQ 348
A L + L H +++ MK E L+ D N AL++ +
Sbjct: 893 AKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKK 952
Query: 349 QENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMEN-EELLWKLHNGDLCS 407
+ EE+ A L E+ L + L+++++ +L +N E+ +K + + +
Sbjct: 953 KTQEEVAA-----------LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTN 1001
Query: 408 PKRSPTSSAIPL 419
K SP PL
Sbjct: 1002 HKPSPDQIIQPL 1013
Score = 40.0 bits (92), Expect = 0.004
Identities = 64/292 (21%), Positives = 127/292 (43%), Gaps = 26/292 (8%)
Query: 137 ASTTCEKLEKARN----ELQTVYEAFVQQHQAEKTERE----------NRLKEFYTREYE 182
AST L +AR+ +LQT + ++++ + + E N +K F++ E +
Sbjct: 136 ASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELK 195
Query: 183 KLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLEL---LKKAYEASLSEI 239
K R +EA K + +EQ+ + ++ ++ I+A E L + L + ++ S
Sbjct: 196 KERALRKDEASKITIW-KEQYRVVQEENQHMQMTIQALQDE-LRIQRDLNQLFQQDSSS- 252
Query: 240 KKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNE-KLKSEEQKRRAREKANLKNPQ 298
+ G + E+ E+Q +L L E +L+ E QK + N ++
Sbjct: 253 RTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK----QTLNARDES 308
Query: 299 IMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARM 358
I L + L+S K + E+ H++ +L + E V + +L+++ ++ E R
Sbjct: 309 IKKLLEMLQS-KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRR 367
Query: 359 DKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKR 410
++ S + Q V++ K S + + L EE+ NG L + +R
Sbjct: 368 FENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEER 419
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 73.2 bits (178), Expect = 4e-13
Identities = 75/322 (23%), Positives = 136/322 (42%), Gaps = 31/322 (9%)
Query: 66 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ 125
+KT ++ + Q+G I LK +L K L I++L + + KQ +L +
Sbjct: 512 KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE 571
Query: 126 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 185
+ +L+ + T LE+A E + E +Q ++ E++
Sbjct: 572 RVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQ--------------- 616
Query: 186 DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEI 245
EE + YK L++ + S L+ + S E L K + +SL+ +
Sbjct: 617 ----EEIDNYKKDLKD------LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS 666
Query: 246 EKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRR----AREKANLKNPQIMY 301
K+LE L +K+E K + LK ++A E S E R RE K+
Sbjct: 667 RLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKA 726
Query: 302 LEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARM-DK 360
+ L+ + E++NEK + +D K+ ++E+ V + V LK +Q ++ A+M ++
Sbjct: 727 QAEVDRLLEILKEVENEK-NDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEE 785
Query: 361 HMAISRQLSTEQAVLQESLEKE 382
L+ LQ+SL K+
Sbjct: 786 ARRREDNLNDSSQQLQDSLRKK 807
Score = 48.1 bits (113), Expect = 2e-05
Identities = 84/372 (22%), Positives = 160/372 (43%), Gaps = 78/372 (20%)
Query: 105 VIQHLLSEREEAL---KQH-KTLSQELVNLRGELVTASTTCEKLE----KARNELQTVYE 156
++Q LSE+E +L K+H +L+ + L T E+ + K ++L+ +E
Sbjct: 635 LLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHE 694
Query: 157 AFVQQHQA-EKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKL 215
A ++ + E ++R L+ TR Y +E+ K + ++ + L E K
Sbjct: 695 AALEARASPEMSDRIQHLEREITR--------YKDESSKAQAEVDRLLEILKEV-ENEKN 745
Query: 216 EIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEK--------------QESL 261
+ + +E LE K ++ +K ++EKK +L E Q+SL
Sbjct: 746 DKDKKIAE-LERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSL 804
Query: 262 EKQINDLKSENDALNEKLK--SEEQKRRAREKANLKNPQ------IMYLE---QELESLK 310
K+ + ++ +AL E ++ +E + A+E++ N + +M +E QELES+K
Sbjct: 805 RKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMK 864
Query: 311 AVLEIKNEKL----------------HQQDIKLMKMEKLV------DNNTALVDKLKRFQ 348
A L + L H +++ MK E L+ D N AL++ +
Sbjct: 865 AKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKK 924
Query: 349 QENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMEN-EELLWKLHNGDLCS 407
+ EE+ A L E+ L + L+++++ +L +N E+ +K + + +
Sbjct: 925 KTQEEVAA-----------LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTN 973
Query: 408 PKRSPTSSAIPL 419
K SP PL
Sbjct: 974 HKPSPDQIIQPL 985
Score = 40.0 bits (92), Expect = 0.004
Identities = 64/292 (21%), Positives = 127/292 (43%), Gaps = 26/292 (8%)
Query: 137 ASTTCEKLEKARN----ELQTVYEAFVQQHQAEKTERE----------NRLKEFYTREYE 182
AST L +AR+ +LQT + ++++ + + E N +K F++ E +
Sbjct: 136 ASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELK 195
Query: 183 KLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLEL---LKKAYEASLSEI 239
K R +EA K + +EQ+ + ++ ++ I+A E L + L + ++ S
Sbjct: 196 KERALRKDEASKITIW-KEQYRVVQEENQHMQMTIQALQDE-LRIQRDLNQLFQQDSSS- 252
Query: 240 KKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNE-KLKSEEQKRRAREKANLKNPQ 298
+ G + E+ E+Q +L L E +L+ E QK + N ++
Sbjct: 253 RTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK----QTLNARDES 308
Query: 299 IMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARM 358
I L + L+S K + E+ H++ +L + E V + +L+++ ++ E R
Sbjct: 309 IKKLLEMLQS-KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRR 367
Query: 359 DKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKR 410
++ S + Q V++ K S + + L EE+ NG L + +R
Sbjct: 368 FENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEER 419
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 73.2 bits (178), Expect = 4e-13
Identities = 100/423 (23%), Positives = 176/423 (41%), Gaps = 74/423 (17%)
Query: 66 EKTLELTQYKTKCENQSGFILQLKQ------LLACGNTKFEALTVV----IQHLLSEREE 115
+K E+++ K + ++Q + +L Q L N + LTV IQ L S+
Sbjct: 2519 KKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNAS 2578
Query: 116 ALKQHKTLSQELVNLRGEL-VTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLK 174
+ L NL EL +T +EK T E +Q+ E ++ L+
Sbjct: 2579 LQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK--MTAKETELQREMHEMAQKTAELQ 2636
Query: 175 EFYTREYEKLR---DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLEL---- 227
E + E +L +EE + K QL+E L + K ++ H +++E
Sbjct: 2637 EELSGEKNRLAGELQLLLEEIKSSKDQLKE----LTLENSELKKSLDCMHKDQVEKEGKV 2692
Query: 228 -------------LKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQ---INDLKSE 271
+K ++A L + K +E+E ++ + L+ K+E L Q I+ LKS
Sbjct: 2693 REEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSS 2752
Query: 272 NDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKME 331
+ LN LK+ Q +K + N LK V ++K E Q KM+
Sbjct: 2753 KEELNNSLKATTQILEELKKTKMDN------------LKYVNQLKKENERAQG----KMK 2796
Query: 332 KLVDNNTALVDKLKRFQQENEELKARMDKHMAIS------RQLSTEQAVLQESLEKESK- 384
L+ + L ++ + Q+E +L+A +K + +L+TE L+E+LE+++K
Sbjct: 2797 LLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKE 2856
Query: 385 ----VNKRLS-------MENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSI 433
++K S +E + + + LCS + S PL P G P PS+
Sbjct: 2857 ADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSV 2916
Query: 434 SPR 436
+ +
Sbjct: 2917 TEK 2919
Score = 61.6 bits (148), Expect = 1e-09
Identities = 85/354 (24%), Positives = 158/354 (44%), Gaps = 53/354 (14%)
Query: 40 TVEKSRQKNPRSLCIQPQTAPDALPP---EKTLELTQYKTKCENQSGFILQLKQLLACGN 96
T E+++ + + TA D L EKT EL ++++C + +
Sbjct: 1957 TSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLH----------CIQVAE 2006
Query: 97 TKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYE 156
+ + T ++Q L S+ E LK L ++L +L + S T +LE +L E
Sbjct: 2007 AEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE 2066
Query: 157 AFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEA---EKYKMQL-----QEQFDNLNA 208
V++ ++ + RL E +YEKL + EA EK + L QE+ L
Sbjct: 2067 LLVKESESLQA----RLSE---SDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRR 2119
Query: 209 AHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDL 268
E ++ IEA ++L + +K K E E SL+D K E+LE+++ +
Sbjct: 2120 GIEKLRVRIEADEKKQLHIAEKL---------KERERENDSLKD----KVENLEREL-QM 2165
Query: 269 KSEN------DALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQ 322
EN DA N K + E K + E A + E +L +L++ E +++ +
Sbjct: 2166 SEENQELVILDAENSKAEVETLKTQIEEMAR----SLKVFELDLVTLRSEKENLTKQIQE 2221
Query: 323 QDIKLMKMEKLVDNNTALVDKLKRFQ-QENEELKARMDKHMAISRQLSTEQAVL 375
+ +L +++KL+ + +L+++ ++ + Q EE K ++ ++L+ A L
Sbjct: 2222 KQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAAL 2275
Score = 58.5 bits (140), Expect = 1e-08
Identities = 78/355 (21%), Positives = 153/355 (43%), Gaps = 45/355 (12%)
Query: 77 KCENQS-GFILQLKQLLACGNTKFEALTVVIQHLLSEREEAL------------KQHKTL 123
+C NQS F ++K NT E + +Q ++++E +L ++ +
Sbjct: 514 QCLNQSQNFAEEMK----AKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC 569
Query: 124 SQELVNLRGELVTASTTCEKLEKARNELQTVYEAF-VQQHQAEKTERENRLKEFYTREYE 182
SQ+L+ R + +KL K E + + A +++ + E+ + E L + E E
Sbjct: 570 SQDLLKKREHHIEQLN--DKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENE 627
Query: 183 KLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKG 242
KL + + E K LQ + ++L +T +++ ++E++ L+ E EI+
Sbjct: 628 KL----LTQMESEKENLQSKINHLETCLKTQQIKSH-EYNERVRTLEMDRENLSVEIRNL 682
Query: 243 HEIEKKSLEDLLSEKQESLEKQ----INDLKSENDALNEKLKSEE---QKRRAREKANLK 295
H + ++ ++K +E Q +D K + + N LK+ + Q K L
Sbjct: 683 HNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLL 742
Query: 296 NPQIMY-------LEQELESLKAVLEIKNEKL-----HQQDIKLMKMEKLVDNNTA-LVD 342
+ +IM L E ESL+ +L+ K+ L HQ+ + + + ++ A ++
Sbjct: 743 SNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIG 802
Query: 343 KLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELL 397
+ E E + D+ S L L+ SLE + ++N L + EEL+
Sbjct: 803 EQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELV 857
Score = 57.0 bits (136), Expect = 3e-08
Identities = 73/352 (20%), Positives = 154/352 (43%), Gaps = 61/352 (17%)
Query: 68 TLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH------- 120
T + Q TK + +L + L+C E+ ++ + E+E+ ++
Sbjct: 347 TAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRS 406
Query: 121 -KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEF--- 176
+TL QE + ++ L ++L++A+N + V +A + + + K + EN L+EF
Sbjct: 407 FQTLDQECIQMKARLT------QELQQAKN-MHNVLQAELDKLTSVKQQLENNLEEFKQK 459
Query: 177 YTREYEKLRDTYIEEAE-KYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEAS 235
R + + + I+E E + M+ ++ +NL +H K E H E
Sbjct: 460 LCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAR-EVCHLEA----------- 507
Query: 236 LSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLK 295
E K+++ L++ Q E ++K++N + L+ ++K +E +
Sbjct: 508 ----------ELKNIKQCLNQSQNFAE----EMKAKNTSQETMLRDLQEKINQQENS--- 550
Query: 296 NPQIMYLEQELESLK-AVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEEL 354
LE LK AV +++ ++ QD+ L K E ++ L DKL + ++E++ L
Sbjct: 551 --------LTLEKLKLAVADLEKQRDCSQDL-LKKREHHIEQ---LNDKLSKTEKESKAL 598
Query: 355 KARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLC 406
+ ++ +L E+ + + K+ ++ E E L K+++ + C
Sbjct: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETC 650
Score = 52.0 bits (123), Expect = 1e-06
Identities = 69/283 (24%), Positives = 125/283 (44%), Gaps = 34/283 (12%)
Query: 160 QQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEA 219
Q+H A + E E + E + + + E + ++ + +NL T++L+ E
Sbjct: 2352 QEHAALEAENSKGEVETLKAKIEGMTQS-LRGLELDVVTIRSEKENL-----TNELQKEQ 2405
Query: 220 SHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALN--- 276
+LE++ ++E L E E EK +++ S E L+ Q+ +L AL+
Sbjct: 2406 ERISELEIINSSFENILQE----KEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQ 2461
Query: 277 EKLKSEEQKRRAR------EKANL-------KNPQIMY------LEQELESLKAVLEIKN 317
E K++EQ ++ EKA L KN I+ L QE+E K LE K+
Sbjct: 2462 EACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKD 2521
Query: 318 EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQE 377
E++ + ++ E+LV + + + + ++++N EL+ + + L ++ A LQ+
Sbjct: 2522 EEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQD 2581
Query: 378 SLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ 420
+LE K L ENE L K+ T+ LQ
Sbjct: 2582 TLEVLQSSYKNL--ENELELTKMDKMSFVEKVNKMTAKETELQ 2622
Score = 50.8 bits (120), Expect = 2e-06
Identities = 83/375 (22%), Positives = 160/375 (42%), Gaps = 59/375 (15%)
Query: 66 EKTLELTQYKTKCEN-------QSGFILQ--LKQLLACGNT----KFEALTVV------I 106
EK L+L K + E +S +L+ LK+L T K E +++ I
Sbjct: 910 EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREI 969
Query: 107 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVY--EAFVQQHQA 164
+ L E + + +L+QE +NL + + + ++ EK+ +EL Y E + +
Sbjct: 970 EELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRC 1029
Query: 165 EKTERENR-LKEFYTREYEK------LRDTYIEEAEKYKMQLQEQFDNLNAAHET--SKL 215
E+T L + Y EK L + E K +L++ + H+ +KL
Sbjct: 1030 EETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKL 1089
Query: 216 EIEASHSE----KLELLKKAYEASLSEIKKGHEIEKKSLED---LLSEKQESLEKQINDL 268
++ +LE +++A + +++ + + E L+ L E+Q ++K++NDL
Sbjct: 1090 AFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDL 1149
Query: 269 KSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLK--------AVLEIKNEKL 320
EN+ L + +K++ E NL++ I +E ES + LE+K L
Sbjct: 1150 LQENEQLMKVMKTK------HECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISL 1203
Query: 321 HQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLE 380
+ +L+++E ++ N K + Q+ +E + + I L T LQ+
Sbjct: 1204 DSYNAQLVQLEAMLRN------KELKLQESEKEKECLQHELQTIRGDLETSN--LQDMQS 1255
Query: 381 KESKVNKRLSMENEE 395
+E K ++ EE
Sbjct: 1256 QEISGLKDCEIDAEE 1270
Score = 50.4 bits (119), Expect = 3e-06
Identities = 76/348 (21%), Positives = 149/348 (42%), Gaps = 41/348 (11%)
Query: 71 LTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHK-TLSQELVN 129
LTQ +++ EN I L+ L K H +ER L+ + LS E+ N
Sbjct: 630 LTQMESEKENLQSKINHLETCLKTQQIK--------SHEYNERVRTLEMDRENLSVEIRN 681
Query: 130 LRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAE------KTERENRLKEFYTREYEK 183
L L + S E + A ELQ E Q+HQ E KT + E + +
Sbjct: 682 LHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQL 741
Query: 184 LRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGH 243
L + +++ Y+ L ++++L ++ + + + LL + ++
Sbjct: 742 LSNEIMDKDRCYQ-DLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANI 800
Query: 244 EIEKKSLEDLLSE---KQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM 300
E+ S+ SE + + K L++ D+L L+S++Q N +
Sbjct: 801 IGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQ----------MNSDLQ 850
Query: 301 YLEQELESLKAVLE---IKNEKLHQQDI--KLMKMEKLVDNNTA----LVDKLKRFQQEN 351
+EL +K +E +K E++HQ + ++ KL ++ +A + + L + +
Sbjct: 851 KQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE 910
Query: 352 EELKARMDK---HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 396
+EL+ DK A ++L +L++SL++ +++ LS+E +E+
Sbjct: 911 KELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEM 958
Score = 46.6 bits (109), Expect = 4e-05
Identities = 51/205 (24%), Positives = 91/205 (44%), Gaps = 22/205 (10%)
Query: 203 FDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLE 262
FDN ++ H +L+ ++ EL K E L +GHE E K + E Q LE
Sbjct: 271 FDNSSSPHLLDQLK-----AQNQELRNKINELELR--LQGHEKEMKGQVNKFQELQLQLE 323
Query: 263 KQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQ 322
K +L + LN K ++ R + + + + LEQ+L+ L ++ ++ +
Sbjct: 324 KAKVELIEKEKVLN---KCRDELVRTTAQYDQASTKYTALEQKLKKLTE--DLSCQRQNA 378
Query: 323 QDIKLMKMEKLVDNNTALVDKLKRFQ-------QENEELKARMDKHMAISRQLSTEQAVL 375
+ + +K+ + ++L R Q QE ++KAR+ + + +Q VL
Sbjct: 379 ESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQEL---QQAKNMHNVL 435
Query: 376 QESLEKESKVNKRLSMENEELLWKL 400
Q L+K + V ++L EE KL
Sbjct: 436 QAELDKLTSVKQQLENNLEEFKQKL 460
Score = 41.6 bits (96), Expect = 0.001
Identities = 46/212 (21%), Positives = 86/212 (40%), Gaps = 26/212 (12%)
Query: 223 EKLELLKKAYEASLSEIKKGHEI-------EKKSLEDLLSEKQESLEKQINDLKSENDAL 275
E+LE L + Y SL ++++ E E + LE LLS +++ L+ SEN+
Sbjct: 1550 EELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQW 1609
Query: 276 NEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVD 335
+KL S + ++ A K + + LE E+ A L+++ L + + + E +
Sbjct: 1610 QQKLTSVTLEMESKLAAEKKQTEQLSLELEV----ARLQLQGLDLSSRSLLGIDTEDAIQ 1665
Query: 336 NNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEE 395
D K E E + D H + +K+++ + L +E
Sbjct: 1666 GRNESCDISKEHTSETTERTPKHDVH---------------QICDKDAQQDLNLDIEKIT 1710
Query: 396 LLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGS 427
+ CS ++SP ++ P + GS
Sbjct: 1711 ETGAVKPTGECSGEQSPDTNYEPPGEDKTQGS 1742
Score = 36.2 bits (82), Expect = 0.060
Identities = 55/208 (26%), Positives = 94/208 (45%), Gaps = 50/208 (24%)
Query: 200 QEQFDNLNAAHETSKLEIEASHSEKLELLK------KAYEASLSEIKKGHEIEKK-SLED 252
QE NL +L ++ + +E L LL + E+ L+E+K E++ K L++
Sbjct: 1766 QEDIHNL-------QLRVKETSNENLRLLHVIEDRDRKVESLLNEMK---ELDSKLHLQE 1815
Query: 253 L-LSEKQES---LEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELES 308
+ L K E+ LEK + +LK EN L+EKL E + + +++ + E
Sbjct: 1816 VQLMTKIEACIELEKIVGELKKENSDLSEKL----------EYFSCDHQELLQRVETSEG 1865
Query: 309 LKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKR--FQQENEELKARMDK----HM 362
L + LE+ +K ++DI DN + D K ENE + R +K H
Sbjct: 1866 LNSDLEMHADKSSREDIG--------DNVAKVNDSWKERFLDVENELSRIRSEKASIEHE 1917
Query: 363 AISRQ-----LSTEQAVLQESLEKESKV 385
A+ + + TE+ L++ E + KV
Sbjct: 1918 ALYLEADLEVVQTEKLCLEKDNENKQKV 1945
Score = 32.3 bits (72), Expect = 0.87
Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 9/89 (10%)
Query: 298 QIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKAR 357
+I LE +L+ LK + + +L + L K ++ V+N LKR Q E+
Sbjct: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICES 78
Query: 358 MDKHMAISRQLSTEQAVLQESLEKESKVN 386
++K T+Q + E KES+VN
Sbjct: 79 LEK---------TKQKISHELQVKESQVN 98
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 72.4 bits (176), Expect = 8e-13
Identities = 77/326 (23%), Positives = 146/326 (44%), Gaps = 29/326 (8%)
Query: 86 LQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLE 145
LQL+++ A K + + I L + + +K+ K + + +L + L
Sbjct: 969 LQLEKVTA--EAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026
Query: 146 KARNELQTVYEAFVQQ-HQAEKTERE-NRLKEFYTREYEKLRDTYIE---EAEKYKMQLQ 200
K RN+ + + ++ + EKT +E + K E L+D E + ++ K+QL
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA 1086
Query: 201 EQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQES 260
++ + L A ++ + E H + + +A ++E+++ E EK S +
Sbjct: 1087 KKEEELQGA--LARGDDETLHKNNALKVVRELQAQIAELQEDFESEKAS--------RNK 1136
Query: 261 LEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLE--IKNE 318
EKQ DL E +AL +L+ A+++ K EQE+ LK LE KN
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR------EQEVAELKKALEEETKNH 1190
Query: 319 KLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQES 378
+ QD++ L + + L ++ KRF+ E+ K ++ +++L+ E VLQ+
Sbjct: 1191 EAQIQDMRQRHATALEELSEQL-EQAKRFKANLEKNKQGLETD---NKELACEVKVLQQV 1246
Query: 379 LEKESKVNKRLSMENEELLWKLHNGD 404
+ K+L + +EL K+ GD
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGD 1272
Score = 70.1 bits (170), Expect = 4e-12
Identities = 93/406 (22%), Positives = 169/406 (41%), Gaps = 57/406 (14%)
Query: 42 EKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEA 101
E++RQK S I+ E+ E + + E Q +L L+ LA K +
Sbjct: 1326 EETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQ---VLALQSQLADTKKKVDD 1382
Query: 102 LTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFV-- 159
I+ L +++ LK + LSQ L + +KLEK +N LQ +
Sbjct: 1383 DLGTIESLEEAKKKLLKDAEALSQRLEE-------KALAYDKLEKTKNRLQQELDDLTVD 1435
Query: 160 ---QQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLE 216
Q+ A E++ + + E + + Y EE ++ + + +E+ A LE
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREK--ETKALSLARALE 1493
Query: 217 IEASHSEKLELLKKAYEASLSEI--------KKGHEIEK--KSLEDLLSEKQESLEKQIN 266
E+ E K A + ++ K HE+EK ++LE + E + LE+ +
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELED 1553
Query: 267 DLKSENDA----------LNEKLKSEEQKR--RAREKANLKNPQIMYLEQELESLKA--V 312
+L++ DA + + + + Q R + EK L Q+ LE ELE +
Sbjct: 1554 ELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRA 1613
Query: 313 LEIKNEKLHQQDIKLMKME---------KLVDNNTALVDKLKRFQQENEELKARMDKHMA 363
L + ++K + D+K ++ + +++ L ++K +Q+E EE +A D+ A
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673
Query: 364 ISRQ-------LSTEQAVLQESLEKESKVNKRLSMENEELLWKLHN 402
S++ L E LQE L + + E +EL ++ N
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITN 1719
Score = 68.2 bits (165), Expect = 1e-11
Identities = 87/313 (27%), Positives = 140/313 (44%), Gaps = 47/313 (15%)
Query: 107 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARN----ELQTVYEAFVQQH 162
+ L ++ EE LK + ++ + GEL ++L + +N +LQ E F +
Sbjct: 852 EELQAKDEELLK----VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE 907
Query: 163 Q------AEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQ-----LQEQFDNLNAAHE 211
+ A+K E E L + +R E+ I + EK KMQ L+EQ D A +
Sbjct: 908 EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ 967
Query: 212 TSKLEIEASHSEKLELLKKAYEASLSEIKKGHEI-EKKSLEDLLSE------KQESLEKQ 264
KL++E +E ++ K E L E + I EKK +ED ++E ++E K
Sbjct: 968 --KLQLEKVTAEA-KIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 265 INDLKSENDA----LNEKLKSEEQKRRAREKANLK--------NPQIMYLEQELESLKAV 312
+ ++++ + L E+LK EE+ R+ EKA K QI L+ +++ LK
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ 1084
Query: 313 LEIKNEKLHQQDIKLMKMEKLVDNNT-----ALVDKLKRFQQENEELKARMDKHMAISRQ 367
L K E+L Q + E L NN L ++ Q++ E KA +K R
Sbjct: 1085 LAKKEEEL-QGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD 1143
Query: 368 LSTEQAVLQESLE 380
LS E L+ LE
Sbjct: 1144 LSEELEALKTELE 1156
Score = 62.4 bits (150), Expect = 8e-10
Identities = 78/361 (21%), Positives = 153/361 (42%), Gaps = 81/361 (22%)
Query: 97 TKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYE 156
TK +L ++ L +EE +Q+K L ++ +L +LEK++ L+
Sbjct: 1483 TKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALE---- 1538
Query: 157 AFVQQHQAEKTERENRLKEFYTREYEKLR----------------DTYIEEAEKYKMQLQ 200
QQ + +T+ E E E KLR T E+ E+ K L
Sbjct: 1539 ---QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 201 EQFDNLNAAHETSK---------------------LEIEASHSEKLELLK--KAYEASLS 237
+Q L A E + +IEA++ + E++K + +A +
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Query: 238 EIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLK-- 295
+ ++ E + S +++ ++ +ES EK++ L++E L E+L S E+ RR E+ +
Sbjct: 1656 DYQRELEEARASRDEIFAQSKES-EKKLKSLEAEILQLQEELASSERARRHAEQERDELA 1714
Query: 296 --------------------NPQIMYLEQELESLKAVLEIKNEKLHQQDIKL--MKMEKL 333
+I LE+ELE ++ +E+ N++ + +++ + E
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 334 VDNNTALV--DKLKRFQQENEELKARM--------DKHMAISRQLSTEQAVLQESLEKES 383
+ + A + ++ +++N+ELKA++ K A L + L+E LE+E+
Sbjct: 1775 AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEA 1834
Query: 384 K 384
K
Sbjct: 1835 K 1835
Score = 59.7 bits (143), Expect = 5e-09
Identities = 88/356 (24%), Positives = 151/356 (42%), Gaps = 87/356 (24%)
Query: 111 SEREEALKQHKTLSQELVNLRGELV-TASTTCE------KLEKARNELQTVYEAFVQQHQ 163
+ R +A KQ + LS+EL L+ EL T TT K E+ EL+ E + H+
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191
Query: 164 AEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQE-----QFDNLNAA--------- 209
A+ + R + E+L + +E+A+++K L++ + DN A
Sbjct: 1192 AQIQDMRQR----HATALEELSEQ-LEQAKRFKANLEKNKQGLETDNKELACEVKVLQQV 1246
Query: 210 -----HETSKL-----EIEASHSE----KLELLKKAYEAS---------LSEI-KKGHEI 245
H+ KL E+ A SE ++EL +KA + L E KKG +
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF 1306
Query: 246 EKK--SLEDLLSEKQESLEKQ----------INDLKSENDALNEKLKSEEQKRRAREK-- 291
K SLE L + QE L+++ I L+ E ++L E+ + EE+ R+ EK
Sbjct: 1307 AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQV 1366
Query: 292 -------ANLKNP------QIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNT 338
A+ K I LE+ + L E +++L ++ + K+EK +
Sbjct: 1367 LALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN--- 1423
Query: 339 ALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENE 394
R QQE ++L +D ++ L +Q + L +E ++ R + E +
Sbjct: 1424 -------RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERD 1472
Score = 58.5 bits (140), Expect = 1e-08
Identities = 72/309 (23%), Positives = 129/309 (41%), Gaps = 26/309 (8%)
Query: 109 LLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQA---E 165
+ ++ +E+ K+ K+L E++ L+ EL ++ E+ R+EL A E
Sbjct: 1671 IFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDE 1730
Query: 166 KTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKL 225
K E R+ + E+ + + K LQ N A E S + + ++L
Sbjct: 1731 KRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQL 1790
Query: 226 ELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQK 285
E K +A L E++ + + K+ L K LE+Q+ E A N+ ++ E+K
Sbjct: 1791 ERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKK 1850
Query: 286 RR--------AREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNN 337
+ R A+ Q+ ++ LK LE E+ + + K+++ +D+
Sbjct: 1851 LKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDA 1910
Query: 338 TALVDKLKRFQQENEELKARMDKHMAIS--------RQLSTEQAVLQ----ESLEKESKV 385
T + L R E LK R+ + IS RQL E A L+ ++ K S V
Sbjct: 1911 TEANEGLSR---EVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDV 1967
Query: 386 NKRLSMENE 394
N+ ++E
Sbjct: 1968 NETQPPQSE 1976
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 72.0 bits (175), Expect = 1e-12
Identities = 96/375 (25%), Positives = 181/375 (48%), Gaps = 60/375 (16%)
Query: 79 ENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREE---ALKQHKTLSQ----ELVNLR 131
ENQ G L C K + L V +++ L E++E +L++ K S EL +++
Sbjct: 879 ENQKGKAAILDLEKTCKELKHQ-LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQ 937
Query: 132 GELVTASTTCEKLEKAR-------NELQTVYEAFVQQHQA----------EKTERENRLK 174
+L+ A T ++ EK NEL+ E +Q +A +KTE EN+L+
Sbjct: 938 EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQ 997
Query: 175 EFYTR-------EYEK---LRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEK 224
+ T+ E EK L++ Y + E +K QLQ F + ++ +++ S EK
Sbjct: 998 QQLTQAAQELAAEKEKISVLQNNYEKSQETFK-QLQSDFYGRESELLATRQDLK-SVEEK 1055
Query: 225 LELLKKAYEASLSEIKKGHEI------EKKSLEDLLSEKQESLE---KQINDLKSENDAL 275
L L ++ ++ ++I +++ K +LE ++K++ L+ K + D++ E
Sbjct: 1056 LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK 1115
Query: 276 NEKLKSEEQKRRAREKANLKNP-QIMYLEQELES--LKAVLEIKNEKLHQQDIKLMKMEK 332
++L +E+ K E+ + +I L +EL+S L+++ EI N K +Q + K+E
Sbjct: 1116 EKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLEL 1175
Query: 333 L--VDNNTALVDKLKRFQQ--------ENEELKAR-MDKHMAISRQLSTEQAVLQESLEK 381
D+ A V++ KR QQ E EELK ++K + ++ ++ +++ E
Sbjct: 1176 QGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEEN 1235
Query: 382 ESKVNKRLSMENEEL 396
E+K+ +++ NE L
Sbjct: 1236 EAKLTMQITALNENL 1250
Score = 65.9 bits (159), Expect = 7e-11
Identities = 88/385 (22%), Positives = 174/385 (45%), Gaps = 43/385 (11%)
Query: 41 VEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQL---KQLLACGNT 97
+++ RQ + L + Q D LE Q K K N + QL KQ
Sbjct: 437 LKEQRQLSSEKLMDKEQQVADLQLKLSRLE-EQLKEKVTNSTELQHQLDKTKQQHQEQQA 495
Query: 98 KFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEA 157
++ T ++ ++ E+ L+Q Q++ NL L + LEK R +L +A
Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
Query: 158 FVQQHQA--EKTERENRLKEFYTREYEKLR---DTYIEEAEKYKMQLQEQFDNLNAAH-- 210
+ + E+ + L+E T+ EKL+ +++ + E Q+QEQ +L AA
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
Query: 211 ----ETSKLEIEASHSE------KLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQES 260
ETS E+ + +E +L++ KA L + ++ L++ L Q +
Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675
Query: 261 L---EKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKN 317
L ++++N + ++ D + KL+ ++Q+ ++ +++LK + YL E ++ + +IK
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQ-DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKK 734
Query: 318 EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAV--- 374
+ ++K K + L D L++ +Q N +L+ R + +S+QL E+ +
Sbjct: 735 LEADSLEVKASKEQALQD--------LQQQRQLNTDLELRATE---LSKQLEMEKEIVSS 783
Query: 375 ----LQESLEKESKVNKRLSMENEE 395
LQ+ E + ++L+ + EE
Sbjct: 784 TRLDLQKKSEALESIKQKLTKQEEE 808
Score = 56.2 bits (134), Expect = 6e-08
Identities = 72/346 (20%), Positives = 153/346 (44%), Gaps = 27/346 (7%)
Query: 70 ELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSE--REEALKQHKTLSQEL 127
E+ K+K + + +Q + + VIQ L +E + ++ L +EL
Sbjct: 171 EIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKEL 230
Query: 128 VNLRGEL----VTASTTCEKLEKARNELQTVY---EAFVQQHQAEKTERENRLKEFYTRE 180
V ++ + + EKL+ +LQ+ Y EA + Q ++E + + Y +E
Sbjct: 231 VQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVA-VYVQE 289
Query: 181 YEKLRDTYIEEAEKYK------MQLQEQFDNLNAAHE---TSKLEIEAS-HSEKLELLKK 230
+KL+ + E +K + ++ ++ + L H SK I+A+ H + L+ +
Sbjct: 290 LQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL 349
Query: 231 AYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRARE 290
S SE H I + E E + L++++++++++ L + K +Q+R +E
Sbjct: 350 QSRLSASETSL-HRIHVELSEK--GEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE 406
Query: 291 KANLK-NPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQ 349
+ L+ +I L +L + L + +L +Q + + EKL+D + D + +
Sbjct: 407 QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQ--RQLSSEKLMDKEQQVADLQLKLSR 464
Query: 350 ENEELKARMDKHMAISRQL-STEQAVLQESLEKESKVNKRLSMENE 394
E+LK ++ + QL T+Q ++ ++S K +N+
Sbjct: 465 LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQND 510
Score = 55.1 bits (131), Expect = 1e-07
Identities = 73/313 (23%), Positives = 136/313 (43%), Gaps = 47/313 (15%)
Query: 87 QLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEK 146
QL Q+ A K E + + HL +E+ L +L Q+ L G++ +KLE
Sbjct: 689 QLDQVTAKLQDKQEHCSQLESHLKEYKEKYL----SLEQKTEELEGQI-------KKLEA 737
Query: 147 ARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNL 206
E++ E +Q Q ++ + N E E K + E ++ LQ++ + L
Sbjct: 738 DSLEVKASKEQALQDLQQQR--QLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL 795
Query: 207 NAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQIN 266
E+ K ++ EK ++LK+ +E E K HE ++ ++E Q+
Sbjct: 796 ----ESIKQKLTKQEEEK-QILKQDFETLSQETKIQHEELNNRIQTTVTELQK------- 843
Query: 267 DLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKN---EKLHQQ 323
+K E +AL +L + + K ++ +LKN + + ++ + A+L+++ E HQ
Sbjct: 844 -VKMEKEALMTELSTVKDKL-SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL 901
Query: 324 DIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKES 383
+++ NT +E +ELK ++K S QL E +QE L +
Sbjct: 902 QVQM--------ENTL---------KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ 944
Query: 384 KVNKRLSMENEEL 396
K+ E ++L
Sbjct: 945 NTLKQNEKEEQQL 957
Score = 54.3 bits (129), Expect = 2e-07
Identities = 68/267 (25%), Positives = 125/267 (46%), Gaps = 53/267 (19%)
Query: 110 LSEREEALKQHKTLS-QELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTE 168
+++ E LK HK S +E+ NL+ + L + + ELQ ++ + EK
Sbjct: 1140 ITKLNEELKSHKLESIKEITNLKDAK-------QLLIQQKLELQGKADSLKAAVEQEKRN 1192
Query: 169 RENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELL 228
++ LK+ +E E+L+ +IE+ K +++E+ + E + KL +
Sbjct: 1193 QQI-LKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEE---------NEAKLTMQ 1242
Query: 229 KKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRA 288
A +L +KK E +S + +SE LEKQ +DL+ E L +++ + +RRA
Sbjct: 1243 ITALNENLGTVKK----EWQSSQRRVSE----LEKQTDDLRGEIAVLEATVQNNQDERRA 1294
Query: 289 REKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQ 348
+ LK E E+E L+ K++++++ +DN TA V +L R
Sbjct: 1295 LLERCLKG------EGEIEKLQT--------------KVLELQRKLDNTTAAVQELGR-- 1332
Query: 349 QENEELKARMDKH-MAISRQLSTEQAV 374
EN+ L+ KH A++R+ + + V
Sbjct: 1333 -ENQSLQI---KHTQALNRKWAEDNEV 1355
Score = 50.8 bits (120), Expect = 2e-06
Identities = 84/332 (25%), Positives = 138/332 (41%), Gaps = 62/332 (18%)
Query: 98 KFEALTVVIQHLLSEREEA--LKQH-KTLSQELV----NLRGELVTASTTCEKLEKARNE 150
K EAL + Q L + EE LKQ +TLSQE L + T T +K++ +
Sbjct: 791 KSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEA 850
Query: 151 LQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIE---EAEKYKMQLQEQFDN-L 206
L T + +N EF +E +K + ++ ++ K QLQ Q +N L
Sbjct: 851 LMTELSTVKDKLSKVSDSLKNSKSEF-EKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909
Query: 207 NAAHETSKL---EIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEK 263
E K E EASH KLEL S+++ L + Q +L++
Sbjct: 910 KEQKELKKSLEKEKEASHQLKLEL--------------------NSMQEQLIQAQNTLKQ 949
Query: 264 QINDLKSENDALNEKLKSEEQKRRARE------------KANLKN---PQIMYLEQELES 308
+ + +NE +S EQK++ E K L+N Q+ QEL +
Sbjct: 950 NEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAA 1009
Query: 309 LK---AVLEIKNEKLH------QQDIKLMKMEKLVDNN--TALVDKLKRFQQENEELKAR 357
K +VL+ EK Q D + E L ++ +KL Q++ + +
Sbjct: 1010 EKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQ 1069
Query: 358 MDKHMAISRQLSTEQAVL-QESLEKESKVNKR 388
+ + ++L T +A L Q+S +KE ++ +R
Sbjct: 1070 IGNQNKLIQELKTAKATLEQDSAKKEQQLQER 1101
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 72.0 bits (175), Expect = 1e-12
Identities = 78/324 (24%), Positives = 149/324 (45%), Gaps = 68/324 (20%)
Query: 100 EALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFV 159
E + ++ L S+ E ++++ TL Q L GEL R L+ +++ +
Sbjct: 645 ERMRANLEELRSQHNEKVEENSTLQQRLEESEGEL-------------RKNLEELFQVKM 691
Query: 160 Q--QHQAEKTERENRLKEFYT------REYEKLRDTYIEEAEKYKMQLQ-------EQFD 204
+ QHQ E + +++L E + R ++ + IEE + K LQ EQ D
Sbjct: 692 EREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQED 751
Query: 205 -------NLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLS-- 255
L A K E+ +SH ++++ LK+ Y+A L +++ E K++E L S
Sbjct: 752 LLRKRERELTALKGALKEEV-SSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRS 810
Query: 256 ----EKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKA 311
+ Q E ++ L+ EN+ L +SEE +RR + L++++E LK
Sbjct: 811 NTSEQDQAGTEMRVKLLQEENEKLQG--RSEELERR-----------VAQLQRQIEDLKG 857
Query: 312 VLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTE 371
E L + + ++ ++E+ ALV K +E E + AR A+ +L
Sbjct: 858 DEAKAKETLKKYEGEIRQLEE------ALVHARK---EEKEAVSAR----RALENELEAA 904
Query: 372 QAVLQESLEKESKVNKRLSMENEE 395
Q L ++ +++ +++++L E+E+
Sbjct: 905 QGNLSQTTQEQKQLSEKLKEESEQ 928
Score = 60.5 bits (145), Expect = 3e-09
Identities = 65/295 (22%), Positives = 128/295 (43%), Gaps = 37/295 (12%)
Query: 111 SEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERE 170
SE ++ L+Q L+ E+ L+ +L + +++ R ++ E QH EK E
Sbjct: 607 SEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHN-EKVEEN 665
Query: 171 NRLKEFYTREYEKLRDTYIE------EAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEK 224
+ L++ +LR E E E+++ ++++ D L+ H+ + EK
Sbjct: 666 STLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREK 725
Query: 225 LELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQES---LEKQINDLKSENDALNEKLKS 281
L+++ +A K+ L+DLL K+E L K+ +L + AL E++ S
Sbjct: 726 GALIEELLQA------------KQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSS 773
Query: 282 EEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALV 341
+Q E LK EQ L+A+ E E ++ + +
Sbjct: 774 HDQ-----EMDKLK-------EQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTE 821
Query: 342 DKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 396
++K Q+ENE+L+ R ++ + R+++ Q +++ E+K + L E+
Sbjct: 822 MRVKLLQEENEKLQGRSEE---LERRVAQLQRQIEDLKGDEAKAKETLKKYEGEI 873
Score = 50.4 bits (119), Expect = 3e-06
Identities = 95/428 (22%), Positives = 171/428 (39%), Gaps = 108/428 (25%)
Query: 71 LTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNL 130
+ Q + + E+ G + K+ L + L + H E +EA+ + L EL
Sbjct: 845 VAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAA 904
Query: 131 RGELVTA--------------STTCEKLEKARN--------------------------- 149
+G L S E+L + +N
Sbjct: 905 QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEAS 964
Query: 150 -----ELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFD 204
ELQ + + ++++ E E + +LKE T E EK R T ++ ++ ++ +E D
Sbjct: 965 RTSTLELQNQLDEYKEKNRRELAEMQRQLKE-KTLEAEKSRLTAMKMQDEMRLMEEELRD 1023
Query: 205 NLNAAHET---------------SKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKS 249
A E +LE ++ + L K E +S+++ E E+++
Sbjct: 1024 YQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELE-EERN 1082
Query: 250 LEDLLSEK----QESLEKQINDLKSENDA-------------LNEKLKS-----EEQKRR 287
DLLSE+ +E +E+ N+L E A N+ LKS E R
Sbjct: 1083 NSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRS 1142
Query: 288 AREKANLK-NPQIMYLEQELESL---KAVLEIKNEKLHQQDIKLMKME------KLVDNN 337
++E ++ +I LE LES +A L++ N +L ++ +K + M+ L D
Sbjct: 1143 SKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRL-ERKVKELVMQVDDEHLSLTDQK 1201
Query: 338 TALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRL-----SME 392
L +LK +++ EE + +D+ L + + LQ LE++ +N+ L SM+
Sbjct: 1202 DQLSLRLKAMKRQVEEAEEEIDR-------LESSKKKLQRELEEQMDMNEHLQGQLNSMK 1254
Query: 393 NEELLWKL 400
+ L KL
Sbjct: 1255 KDLRLKKL 1262
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 71.6 bits (174), Expect = 1e-12
Identities = 85/343 (24%), Positives = 146/343 (42%), Gaps = 79/343 (23%)
Query: 107 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEK 166
+ L +E K+++ L +++ NL+ TCEK+E E +
Sbjct: 628 EELENELHHLEKENELLQKKITNLK-------ITCEKIEALEQE-------------NSE 667
Query: 167 TERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLE 226
ERENR + ++ L +E EK QL E+ NL L+ + +L+
Sbjct: 668 LERENRKLKKTLDSFKNLT-FQLESLEKENSQLDEE--NLELRRNVESLKCASMKMAQLQ 724
Query: 227 LLKKAYEASLSEIKKGHE--------------------IEKKSLEDLL---SEKQESLEK 263
L K E+ ++KKG E IE + L+ L ++K + LE
Sbjct: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Query: 264 QINDLKSENDALN---EKLKSEEQKRRAREKANLKNPQ--------IMYLEQELESLKAV 312
++ DL+ EN L E+LK ++ EK N Q LE+E + L+
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 313 LEIKNEKLHQQDIKLMKMEKLVDNNTALVD---------KLKRFQQENEEL--KARMD-- 359
EIK+ L + ++K+ +EK +N T + +LK ++EN+EL +A +D
Sbjct: 845 AEIKDTTLEENNVKIGNLEK--ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
Query: 360 -----KHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELL 397
+ +S +L T+Q + LEK + +++ + E LL
Sbjct: 903 TLVTLREDLVSEKLKTQQ--MNNDLEKLTHELEKIGLNKERLL 943
Score = 69.3 bits (168), Expect = 6e-12
Identities = 81/325 (24%), Positives = 146/325 (44%), Gaps = 43/325 (13%)
Query: 107 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQA-- 164
QHL E +A + + L QEL +L+ E++E LQ + ++
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
Query: 165 ----------EKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHET-- 212
EK R ++L+ +R E+L D E YK +++E ++ ET
Sbjct: 307 MYRDELDALREKAVRVDKLESEVSRYKERLHD-----IEFYKARVEELKEDNQVLLETKT 361
Query: 213 ---SKLEIEASHSEKLELLKK---AYEASLSEIKKGHEIEKKSLEDLLSEKQ--ESLEKQ 264
+LE + S+KL L+K +A L +++ ++++K +E+L+ E E +KQ
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
Query: 265 IND------LKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESL-KAVLEIKN 317
D + E + +L QK E L + +++ LE E +SL K V E++
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481
Query: 318 --EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVL 375
+ + K++KMEK N L K++ + E + K + +S+ L E+A L
Sbjct: 482 TVDSVEGNASKILKMEK---ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL 538
Query: 376 QESLEKESKVNKR----LSMENEEL 396
++++E + ++R L ENE L
Sbjct: 539 EKTIETLRENSERQIKILEQENEHL 563
Score = 58.9 bits (141), Expect = 9e-09
Identities = 86/384 (22%), Positives = 159/384 (41%), Gaps = 62/384 (16%)
Query: 70 ELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVN 129
E+++YK + + + ++++L E T++ L R + K H+ L +E +
Sbjct: 328 EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHE-LEKENLQ 386
Query: 130 LRGEL----VTASTTCEKLEKARNELQTVYEAFVQQH--------QAEKTERENRLKEFY 177
L+ +L + +K+E+ E T+ A Q + E+ R + L E
Sbjct: 387 LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP 446
Query: 178 TR----EYEKLRDTYIEEAEKYKMQLQEQFDNLNA--------AHETSKLEIEASH-SEK 224
+ E +L + + + E L + + L A + K+E E S+K
Sbjct: 447 QKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506
Query: 225 LELLK------KAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEK 278
+E+L+ K + + K EK LE + +E+ E+QI L+ EN+ LN+
Sbjct: 507 VEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT 566
Query: 279 LKSEEQKRRAREKANLK----------------NPQIMYLEQELESLKAVLEIKNEK--- 319
+ S Q+ + +A +K + ++ +E E +K LE EK
Sbjct: 567 VSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGER 626
Query: 320 -------LHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQ 372
LH + + ++K + N +K++ +QEN EL+ R ++ + +
Sbjct: 627 AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELE-RENRKLKKTLDSFKNL 685
Query: 373 AVLQESLEKESKVNKRLSMENEEL 396
ESLEKE N +L EN EL
Sbjct: 686 TFQLESLEKE---NSQLDEENLEL 706
Score = 53.1 bits (126), Expect = 5e-07
Identities = 81/384 (21%), Positives = 165/384 (42%), Gaps = 79/384 (20%)
Query: 69 LELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSERE---EALKQHKTLSQ 125
LE++ ENQ +L++ L N K + L +Q L E + + L++ K S+
Sbjct: 754 LEVSYQGLDIENQ-----RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSK 808
Query: 126 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKT------------EREN-- 171
L L E + +LEK + +L+ + QQ + + T E+EN
Sbjct: 809 RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868
Query: 172 -------------RLKEFYTREYEKLRDTYI---------EEAEKYKMQLQEQFDNLNA- 208
RLKE E ++ I E+ K++ Q+ ++L
Sbjct: 869 LSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928
Query: 209 AHETSKLEI---------EASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQE 259
HE K+ + +++ + +LL+ E++L KK EI+++ + L + +E
Sbjct: 929 THELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTL---KKSLEIKEEKIAALEARLEE 985
Query: 260 S------LEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVL 313
S L +++ +K +AL ++ ++++R + + + + E+ + +L
Sbjct: 986 STNYNQQLRQELKTVKKNYEALKQR---QDEERMVQSSPPISGEDNKWERESQETTRELL 1042
Query: 314 EIKNEKLH-QQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQ 372
++K+ + +++ ++ EK AL +LK+ + +N L+A++ +A+ RQ +
Sbjct: 1043 KVKDRLIEVERNNATLQAEK-----QALKTQLKQLETQNNNLQAQI---LALQRQTVS-- 1092
Query: 373 AVLQESLEKESKVNKRLSMENEEL 396
LQE N +L +EN L
Sbjct: 1093 --LQEQNTTLQTQNAKLQVENSTL 1114
Score = 44.7 bits (104), Expect = 2e-04
Identities = 82/387 (21%), Positives = 162/387 (41%), Gaps = 45/387 (11%)
Query: 67 KTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQE 126
+T+ L + T + Q+ + L N++ +L LL ++ +++++ +E
Sbjct: 1089 QTVSLQEQNTTLQTQNAKLQVENSTL---NSQSTSLMNQNAQLLIQQSSLENENESVIKE 1145
Query: 127 LVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRD 186
+L+ + EKLE + YE+ + +H K+ +N E+ L D
Sbjct: 1146 REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN-----LEVEHRDLED 1200
Query: 187 TY---------IEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLS 237
Y +E+ EK QE+ N HET E + E + L Y L
Sbjct: 1201 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN-DRLNHTYSQLLK 1259
Query: 238 EIKKGHEIEKKSLEDLLSE---KQESLEKQINDLKSEN---DALNEKLKSEEQKRRAREK 291
E + + + K+L+ LL+ +Q LE + + LK + D + KL + + + ++ K
Sbjct: 1260 ETEV-LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL-NNQCELLSQLK 1317
Query: 292 ANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN 351
NL+ L+Q L ++N L +Q+++ + + +DKL +++
Sbjct: 1318 GNLEEENRHLLDQ-----IQTLMLQNRTLLEQNMESKDLFHV--EQRQYIDKLNELRRQK 1370
Query: 352 EELKAR-MDKHMAISRQLSTEQA-VLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPK 409
E+L+ + MD++ + + + K K K ++ E ++ L +P
Sbjct: 1371 EKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSL-------TLTPT 1423
Query: 410 RSPTSSA---IPLQSPRNSGSFPSPSI 433
RS +S +P Q ++S S S S+
Sbjct: 1424 RSDSSEGFLQLPHQDSQDSSSVGSNSL 1450
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 71.6 bits (174), Expect = 1e-12
Identities = 85/343 (24%), Positives = 146/343 (42%), Gaps = 79/343 (23%)
Query: 107 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEK 166
+ L +E K+++ L +++ NL+ TCEK+E E +
Sbjct: 628 EELENELHHLEKENELLQKKITNLK-------ITCEKIEALEQE-------------NSE 667
Query: 167 TERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLE 226
ERENR + ++ L +E EK QL E+ NL L+ + +L+
Sbjct: 668 LERENRKLKKTLDSFKNLT-FQLESLEKENSQLDEE--NLELRRNVESLKCASMKMAQLQ 724
Query: 227 LLKKAYEASLSEIKKGHE--------------------IEKKSLEDLL---SEKQESLEK 263
L K E+ ++KKG E IE + L+ L ++K + LE
Sbjct: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Query: 264 QINDLKSENDALN---EKLKSEEQKRRAREKANLKNPQ--------IMYLEQELESLKAV 312
++ DL+ EN L E+LK ++ EK N Q LE+E + L+
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 313 LEIKNEKLHQQDIKLMKMEKLVDNNTALVD---------KLKRFQQENEEL--KARMD-- 359
EIK+ L + ++K+ +EK +N T + +LK ++EN+EL +A +D
Sbjct: 845 AEIKDTTLEENNVKIGNLEK--ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
Query: 360 -----KHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELL 397
+ +S +L T+Q + LEK + +++ + E LL
Sbjct: 903 TLVTLREDLVSEKLKTQQ--MNNDLEKLTHELEKIGLNKERLL 943
Score = 69.3 bits (168), Expect = 6e-12
Identities = 81/325 (24%), Positives = 146/325 (44%), Gaps = 43/325 (13%)
Query: 107 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQA-- 164
QHL E +A + + L QEL +L+ E++E LQ + ++
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
Query: 165 ----------EKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHET-- 212
EK R ++L+ +R E+L D E YK +++E ++ ET
Sbjct: 307 MYRDELDALREKAVRVDKLESEVSRYKERLHD-----IEFYKARVEELKEDNQVLLETKT 361
Query: 213 ---SKLEIEASHSEKLELLKK---AYEASLSEIKKGHEIEKKSLEDLLSEKQ--ESLEKQ 264
+LE + S+KL L+K +A L +++ ++++K +E+L+ E E +KQ
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
Query: 265 IND------LKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESL-KAVLEIKN 317
D + E + +L QK E L + +++ LE E +SL K V E++
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481
Query: 318 --EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVL 375
+ + K++KMEK N L K++ + E + K + +S+ L E+A L
Sbjct: 482 TVDSVEGNASKILKMEK---ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL 538
Query: 376 QESLEKESKVNKR----LSMENEEL 396
++++E + ++R L ENE L
Sbjct: 539 EKTIETLRENSERQIKILEQENEHL 563
Score = 58.9 bits (141), Expect = 9e-09
Identities = 86/384 (22%), Positives = 159/384 (41%), Gaps = 62/384 (16%)
Query: 70 ELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVN 129
E+++YK + + + ++++L E T++ L R + K H+ L +E +
Sbjct: 328 EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHE-LEKENLQ 386
Query: 130 LRGEL----VTASTTCEKLEKARNELQTVYEAFVQQH--------QAEKTERENRLKEFY 177
L+ +L + +K+E+ E T+ A Q + E+ R + L E
Sbjct: 387 LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP 446
Query: 178 TR----EYEKLRDTYIEEAEKYKMQLQEQFDNLNA--------AHETSKLEIEASH-SEK 224
+ E +L + + + E L + + L A + K+E E S+K
Sbjct: 447 QKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506
Query: 225 LELLK------KAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEK 278
+E+L+ K + + K EK LE + +E+ E+QI L+ EN+ LN+
Sbjct: 507 VEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT 566
Query: 279 LKSEEQKRRAREKANLK----------------NPQIMYLEQELESLKAVLEIKNEK--- 319
+ S Q+ + +A +K + ++ +E E +K LE EK
Sbjct: 567 VSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGER 626
Query: 320 -------LHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQ 372
LH + + ++K + N +K++ +QEN EL+ R ++ + +
Sbjct: 627 AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELE-RENRKLKKTLDSFKNL 685
Query: 373 AVLQESLEKESKVNKRLSMENEEL 396
ESLEKE N +L EN EL
Sbjct: 686 TFQLESLEKE---NSQLDEENLEL 706
Score = 55.5 bits (132), Expect = 1e-07
Identities = 83/383 (21%), Positives = 165/383 (43%), Gaps = 78/383 (20%)
Query: 69 LELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSERE---EALKQHKTLSQ 125
LE++ ENQ +L++ L N K + L +Q L E + + L++ K S+
Sbjct: 754 LEVSYQGLDIENQ-----RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSK 808
Query: 126 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKT------------EREN-- 171
L L E + +LEK + +L+ + QQ + + T E+EN
Sbjct: 809 RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868
Query: 172 -------------RLKEFYTREYEKLRDTYI---------EEAEKYKMQLQEQFDNLNA- 208
RLKE E ++ I E+ K++ Q+ ++L
Sbjct: 869 LSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928
Query: 209 AHETSKLEI--------EASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQES 260
HE K+ + E S ++ +LL+ E++L KK EI+++ + L + +ES
Sbjct: 929 THELEKIGLNKERLLHDEQSTDDRYKLLESKLESTL---KKSLEIKEEKIAALEARLEES 985
Query: 261 ------LEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLE 314
L +++ +K +AL ++ ++++R + + + + E+ + +L+
Sbjct: 986 TNYNQQLRQELKTVKKNYEALKQR---QDEERMVQSSPPISGEDNKWERESQETTRELLK 1042
Query: 315 IKNEKLH-QQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQA 373
+K+ + +++ ++ EK AL +LK+ + +N L+A++ +A+ RQ +
Sbjct: 1043 VKDRLIEVERNNATLQAEK-----QALKTQLKQLETQNNNLQAQI---LALQRQTVS--- 1091
Query: 374 VLQESLEKESKVNKRLSMENEEL 396
LQE N +L +EN L
Sbjct: 1092 -LQEQNTTLQTQNAKLQVENSTL 1113
Score = 44.7 bits (104), Expect = 2e-04
Identities = 82/387 (21%), Positives = 162/387 (41%), Gaps = 45/387 (11%)
Query: 67 KTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQE 126
+T+ L + T + Q+ + L N++ +L LL ++ +++++ +E
Sbjct: 1088 QTVSLQEQNTTLQTQNAKLQVENSTL---NSQSTSLMNQNAQLLIQQSSLENENESVIKE 1144
Query: 127 LVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRD 186
+L+ + EKLE + YE+ + +H K+ +N E+ L D
Sbjct: 1145 REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN-----LEVEHRDLED 1199
Query: 187 TY---------IEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLS 237
Y +E+ EK QE+ N HET E + E + L Y L
Sbjct: 1200 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN-DRLNHTYSQLLK 1258
Query: 238 EIKKGHEIEKKSLEDLLSE---KQESLEKQINDLKSEN---DALNEKLKSEEQKRRAREK 291
E + + + K+L+ LL+ +Q LE + + LK + D + KL + + + ++ K
Sbjct: 1259 ETEV-LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL-NNQCELLSQLK 1316
Query: 292 ANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN 351
NL+ L+Q L ++N L +Q+++ + + +DKL +++
Sbjct: 1317 GNLEEENRHLLDQ-----IQTLMLQNRTLLEQNMESKDLFHV--EQRQYIDKLNELRRQK 1369
Query: 352 EELKAR-MDKHMAISRQLSTEQA-VLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPK 409
E+L+ + MD++ + + + K K K ++ E ++ L +P
Sbjct: 1370 EKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSL-------TLTPT 1422
Query: 410 RSPTSSA---IPLQSPRNSGSFPSPSI 433
RS +S +P Q ++S S S S+
Sbjct: 1423 RSDSSEGFLQLPHQDSQDSSSVGSNSL 1449
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 71.2 bits (173), Expect = 2e-12
Identities = 80/349 (22%), Positives = 156/349 (44%), Gaps = 38/349 (10%)
Query: 71 LTQYKTKCE-NQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVN 129
L ++KTKCE +Q+ LK+ + F+ L + L + E +++K L QE+ +
Sbjct: 1454 LAEWKTKCEESQAELEASLKESRSLSTELFK-LKNAYEEALDQLETVKRENKNLEQEIAD 1512
Query: 130 LRGELVTASTTCEKLEKARNELQ----------TVYEAFVQQHQAEKTERENRLKEFYTR 179
L ++ T +LEK+R +++ EA ++ +A+ + L + +
Sbjct: 1513 LTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSE 1572
Query: 180 EYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEI 239
K+ + EE E+ K Q + + +A L+ E + LKK E L+EI
Sbjct: 1573 IDRKIAEK-DEEIEQLKRNYQRTVETMQSA-----LDAEVRSRNEAIRLKKKMEGDLNEI 1626
Query: 240 KKGHEIEKKSLEDLLSEKQESLEKQINDLKSE-NDALNEKLKSEEQKRRAREKANLKNPQ 298
+ + + L + S++ Q+ D + +DAL + +EQ +ANL
Sbjct: 1627 EIQLSHANRQAAETLKHLR-SVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANL---- 1681
Query: 299 IMYLEQELESLKAVLE--IKNEKLHQQDI--KLMKMEKLVDNNTALVDKLKRFQQENEEL 354
L+ E+E L+A LE + KL +Q++ +++ L NT+L+ K+ + + +L
Sbjct: 1682 ---LQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQL 1738
Query: 355 KARMDKHMAISRQLS-------TEQAVLQESLEKESKVNKRLSMENEEL 396
++ ++ +R T+ A++ E L+KE + L + L
Sbjct: 1739 QSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1787
Score = 58.5 bits (140), Expect = 1e-08
Identities = 64/301 (21%), Positives = 133/301 (44%), Gaps = 49/301 (16%)
Query: 143 KLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQ 202
K++ +T E + + +KT+ E E +E E+ T ++E ++Q+Q +
Sbjct: 836 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAE 895
Query: 203 FDNLNAAHE------TSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIE------KKSL 250
+NL A E +K ++EA E E + E + K ++E KK +
Sbjct: 896 SENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 955
Query: 251 EDL------LSEKQESLEKQINDLKSENDALNEKLKSEEQKRRA---------------R 289
+DL + +++ + E ++ +L E L+E + ++++A
Sbjct: 956 DDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEE 1015
Query: 290 EKANLKNPQIMYLEQELESLKAVLE---------IKNEKLHQQDIKLMKMEKLVD---NN 337
+K N N LEQ++E L++ LE +N++ + D+KL + E ++D +
Sbjct: 1016 DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQ-ESILDLENDK 1074
Query: 338 TALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQ---ESLEKESKVNKRLSMENE 394
L ++LK+ E +L+++++ + Q + LQ E LE+E + + + E
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTE 1134
Query: 395 E 395
+
Sbjct: 1135 K 1135
Score = 56.2 bits (134), Expect = 6e-08
Identities = 75/350 (21%), Positives = 151/350 (43%), Gaps = 29/350 (8%)
Query: 66 EKTLELTQYKTK--CENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKT- 122
EK T+ K K E SG + +L EA + L +E ++ +KT
Sbjct: 966 EKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTK 1025
Query: 123 --LSQELVNLRGELVTASTTCEKLEKARNELQ---TVYEAFVQQHQAEKTERENRLKEFY 177
L Q++ +L L LE+ + +L+ + + + + +K + + RLK+
Sbjct: 1026 SKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKK-- 1083
Query: 178 TREYEKLR-DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSE--KLELLKKAYEA 234
+++E + + +E+ + +Q Q++ L A E + EIEA + K E + Y
Sbjct: 1084 -KDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYAR 1142
Query: 235 SLSEIKKGHE----IEKKSLEDLLSEKQES----LEKQINDLKSENDALNEKLKSEEQKR 286
L E+ + E + +E L++K+E+ L + + + +++A+ L+ +
Sbjct: 1143 ELEELSERLEEAGGVTSTQIE--LNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADS 1200
Query: 287 RAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMK--MEKLVDNNTALVDKL 344
A + N Q + + E E + LEI + + + K +EK+ L D+L
Sbjct: 1201 VAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKIC---RTLEDQL 1257
Query: 345 KRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENE 394
+ +NEE++ + + +L TE L LE++ + +LS +
Sbjct: 1258 SEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQ 1307
Score = 45.1 bits (105), Expect = 1e-04
Identities = 72/321 (22%), Positives = 127/321 (39%), Gaps = 51/321 (15%)
Query: 87 QLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEK 146
++KQ L ++F+ + I L S E K L + L +L A E++++
Sbjct: 1213 RVKQKLEKEKSEFK---LEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQR 1269
Query: 147 ARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNL 206
+ +EL T Q +A + R+ KE + + + + ++ E+ K QL+E+
Sbjct: 1270 SLSELTTQKSRL--QTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAK 1327
Query: 207 NA-AHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQI 265
NA AH S +LL++ YE E ++G K L+ LS+ + +
Sbjct: 1328 NALAHALQ------SSRHDCDLLREQYE----EEQEG----KAELQRALSKANSEVAQWR 1373
Query: 266 NDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDI 325
K E DA+ + EE K++ ++ L+ E++ +
Sbjct: 1374 T--KYETDAIQRTEELEEAKKKLAQR---------------------LQDSEEQVEAVNA 1410
Query: 326 KLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHM----AISRQLSTEQAVLQESLEK 381
K +EK V+ L + L A +DK + + T+ Q LE
Sbjct: 1411 KCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEA 1470
Query: 382 ESKVNKRLSMENEELLWKLHN 402
K ++ LS E L+KL N
Sbjct: 1471 SLKESRSLSTE----LFKLKN 1487
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 71.2 bits (173), Expect = 2e-12
Identities = 77/334 (23%), Positives = 139/334 (41%), Gaps = 43/334 (12%)
Query: 97 TKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYE 156
TK +L ++ L +EE + +K L E+ +L +LEK++ L+T
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET--- 1539
Query: 157 AFVQQHQAEKTERENRLKEFYTREYEKLR----------------DTYIEEAEKYKMQLQ 200
Q + KT+ E E E KLR E+ E+ + QLQ
Sbjct: 1540 ----QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 201 EQFDNLNAAHETSKLE--IEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQ 258
Q E + + + A+ +KLE K E KG E K L L ++ +
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 259 ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQEL---ESLKAVLEI 315
+ ++++ D ++ D + K E+K ++ E +M L+++L E + ++
Sbjct: 1656 D-FQRELEDARASRDEIFATAKENEKKAKSLEA------DLMQLQEDLAAAERARKQADL 1708
Query: 316 KNEKLHQQ-DIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMD-------KHMAISRQ 367
+ E+L ++ L L D L ++ + ++E EE + M+ K + Q
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 368 LSTEQAVLQESLEKESKVNKRLSMENEELLWKLH 401
LS E A + + +K ++L +N+EL KLH
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLH 1802
Score = 64.7 bits (156), Expect = 2e-10
Identities = 76/315 (24%), Positives = 141/315 (44%), Gaps = 40/315 (12%)
Query: 85 ILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKL 144
I +LK LA + +A + ++++ ALK+ + L + +L+ +L + K
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 145 EKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFD 204
EK + +L EA KTE E+ L T ++LR +E K L E+
Sbjct: 1138 EKQKRDLGEELEAL-------KTELEDTLDS--TATQQELRAKREQEVTVLKKALDEE-- 1186
Query: 205 NLNAAHETSKLEIEASH-------SEKLELLKKAYEASLSEIKKGHEIEKKSLED---LL 254
+HE E+ H +E+LE K+A +A+L + K+ E E L +L
Sbjct: 1187 --TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQTLEKENADLAGELRVL 1243
Query: 255 SEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLE 314
+ ++ +E + L+++ L K E R +A L N ++ L+ E+ES+ +
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGE-----RARAEL-NDKVHKLQNEVESVTGM-- 1295
Query: 315 IKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAV 374
L++ + K +K+ K V + ++ + + QE K + + RQL E+
Sbjct: 1296 -----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL---RQLEEERNS 1347
Query: 375 LQESLEKESKVNKRL 389
LQ+ L++E + + L
Sbjct: 1348 LQDQLDEEMEAKQNL 1362
Score = 62.8 bits (151), Expect = 6e-10
Identities = 72/349 (20%), Positives = 153/349 (43%), Gaps = 27/349 (7%)
Query: 70 ELTQYKTKCENQSGFILQLKQLLACGNTKFEA----LTVVIQHLLSEREEALKQHKTLSQ 125
+L +Y+T+ E++ + + L A K E L + + REEA+KQ + L
Sbjct: 1597 QLHEYETELEDER----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652
Query: 126 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 185
++ + + EL A + +++ E + +A+ E + + E+ R
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKE---------NEKKAKSLEADLMQLQEDLAAAERAR 1703
Query: 186 DTYIEEAEKYKMQLQEQFDNLNAAH-ETSKLEIE-ASHSEKLELLKKAYEASLSEIKKGH 243
E E+ +L NA E +LE A E+LE + EA ++K
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763
Query: 244 EIEKKSLEDLLSEKQ--ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLK--NPQI 299
+ ++ +L +E+ + E L+ +N L KL E +++ K+ + +I
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1823
Query: 300 MYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN----EELK 355
LE+++E + + L Q+D KL ++ V++ + ++ K ++ ++LK
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 356 ARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGD 404
++++ S++++ + LQ L++ ++ N+ + E L KL G+
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1932
Score = 61.6 bits (148), Expect = 1e-09
Identities = 79/340 (23%), Positives = 142/340 (41%), Gaps = 42/340 (12%)
Query: 87 QLKQLLACGNTKFEALTVVIQHLLSEREEAL-----KQHKTLSQELVNLRGELVTASTTC 141
Q KQ + K EA +Q S+ E A K HK L E+ ++ G L A
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK-LQNEVESVTGMLNEAEGKA 1303
Query: 142 EKLEK----ARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKM 197
KL K ++LQ E +Q+ +K +L++ E L+D EE E K
Sbjct: 1304 IKLAKDVASLSSQLQDTQE-LLQEETRQKLNVSTKLRQL-EEERNSLQDQLDEEMEA-KQ 1360
Query: 198 QLQEQFDNLNAAHETSKLEIE--ASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLS 255
L+ LN SK +++ AS E LE KK ++ + + + +E EK + D L
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAAAYDKLE 1419
Query: 256 EKQESLEKQINDLKSENDALNEKLKSEEQKRRAREK--ANLKNPQIMYLEQE-------- 305
+ + L+++++DL + D + + + E+K+R ++ A KN Y ++
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479
Query: 306 ---------LESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKA 356
+L+ LE K E + +ME LV + + + ++ L+
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 357 RMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 396
+M+ ++ T+ L++ L+ RL + + L
Sbjct: 1540 QME-------EMKTQLEELEDELQATEDAKLRLEVNMQAL 1572
Score = 60.8 bits (146), Expect = 2e-09
Identities = 79/327 (24%), Positives = 152/327 (46%), Gaps = 31/327 (9%)
Query: 86 LQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLE 145
LQL+++ A K + L I + + + K+ K L + + +L L + L
Sbjct: 969 LQLEKVTA--EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 146 KARNELQT-VYEAFVQQHQAEKTERE-----NRLKEFYTREYEKLRDTYIEEAEKYKMQL 199
K +N+ ++ + E V+ + EK+ +E +L+ + +E++ D + AE KMQL
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE-LKMQL 1085
Query: 200 QEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEK-- 257
++ + L AA ++L+ E + +K LKK E +GH + + EDL SE+
Sbjct: 1086 AKKEEELQAA--LARLDDEIA--QKNNALKKIREL------EGHISDLQ--EDLDSERAA 1133
Query: 258 QESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKN 317
+ EKQ DL E +AL +L+ +++ K EQE+ LK L+ +
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR------EQEVTVLKKALD-EE 1186
Query: 318 EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQE 377
+ H+ ++ M+ +K L ++L++F++ L + L+ E VL +
Sbjct: 1187 TRSHEAQVQEMR-QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245
Query: 378 SLEKESKVNKRLSMENEELLWKLHNGD 404
+ ++ K+L + +EL K +G+
Sbjct: 1246 AKQEVEHKKKKLEAQVQELQSKCSDGE 1272
Score = 53.1 bits (126), Expect = 5e-07
Identities = 80/356 (22%), Positives = 156/356 (43%), Gaps = 47/356 (13%)
Query: 66 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ 125
+K +LT+ K + Q +L + A ++ +L E E L++ + Q
Sbjct: 880 QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ 939
Query: 126 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 185
+L R ++ E E+ E EA Q+ Q EK E ++K+ + +
Sbjct: 940 QLQAERKKMAQQMLDLE--EQLEEE-----EAARQKLQLEKVTAEAKIKKL--EDEILVM 990
Query: 186 DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEI 245
D + K + L+E+ +L T+ L E ++ L LK +E+ +SE++ +
Sbjct: 991 DDQNNKLSKERKLLEERISDL-----TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1045
Query: 246 EKKSLEDLLSEKQE------SLEKQINDLKSENDALNEKLKSEE---------------Q 284
E+KS ++L K++ +QI DL+++ L +L +E Q
Sbjct: 1046 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1105
Query: 285 KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKL 344
K A +K I L+++L+S +A K EK ++D+ E+L T L D L
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARN-KAEK-QKRDLG----EELEALKTELEDTL 1159
Query: 345 KRFQQENEELKARMDKHM-----AISRQLSTEQAVLQESLEKESKVNKRLSMENEE 395
+ +EL+A+ ++ + A+ + + +A +QE +K ++ + L+ + E+
Sbjct: 1160 DSTATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Score = 49.7 bits (117), Expect = 5e-06
Identities = 50/257 (19%), Positives = 122/257 (47%), Gaps = 16/257 (6%)
Query: 156 EAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKL 215
E ++ + +KT+ + E +E E+ EE + QLQ + + L A E ++
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-LYAEAEEMRV 911
Query: 216 EIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDAL 275
+ A E E+L + E +G +++ + + ++++ LE+Q+ + ++ L
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK--MAQQMLDLEEQLEEEEAARQKL 969
Query: 276 N-EKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLV 334
EK+ +E + ++ ++ + + Q L +E + L+ + L +++ K + KL
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 335 DNNTALVDKL-------KRFQQENEELKARMDKHMA-ISRQLSTEQAVLQE----SLEKE 382
+ + +++ +L ++ +QE E+LK +++ + Q++ QA + E +KE
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 383 SKVNKRLSMENEELLWK 399
++ L+ ++E+ K
Sbjct: 1090 EELQAALARLDDEIAQK 1106
Score = 38.9 bits (89), Expect = 0.009
Identities = 40/160 (25%), Positives = 67/160 (41%), Gaps = 14/160 (8%)
Query: 256 EKQESLEKQINDLKSENDALNEKLKSEEQKR-RAREKANLKNPQIMY---LEQELESLKA 311
E+ ++ E ++ K +LK EQK + E+ NL Q+ L E E ++
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 312 VLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTE 371
L K ++L E L + L ++ R QQ E K + + + QL E
Sbjct: 912 RLAAKKQELE---------EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 372 QAVLQE-SLEKESKVNKRLSMENEELLWKLHNGDLCSPKR 410
+A Q+ LEK + K +E+E L+ N L ++
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Score = 34.7 bits (78), Expect = 0.17
Identities = 41/170 (24%), Positives = 78/170 (45%), Gaps = 24/170 (14%)
Query: 111 SEREEALKQHKTLSQELVNLRGELVTA-STTCEKLEKARNELQTVYEAFVQQHQAEKTER 169
S R++ +Q+K L +L + G + + +T LE +L E V+Q EK
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL----EEQVEQEAREKQAA 1840
Query: 170 ENRLKEFYTREYEKLRDTYIEEAEKYKM--QLQEQFDNLNAAHETSKLEIEASHSEKLEL 227
LK+ + +KL++ ++ ++ KM Q +EQ + NA + K ++E + E +
Sbjct: 1841 TKSLKQ----KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1896
Query: 228 LKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNE 277
+ + K E+ D +E E++ +++N LKS+ NE
Sbjct: 1897 -------NANRRKLQREL------DEATESNEAMGREVNALKSKLRRGNE 1933
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 71.2 bits (173), Expect = 2e-12
Identities = 77/334 (23%), Positives = 139/334 (41%), Gaps = 43/334 (12%)
Query: 97 TKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYE 156
TK +L ++ L +EE + +K L E+ +L +LEK++ L+T
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET--- 1546
Query: 157 AFVQQHQAEKTERENRLKEFYTREYEKLR----------------DTYIEEAEKYKMQLQ 200
Q + KT+ E E E KLR E+ E+ + QLQ
Sbjct: 1547 ----QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 201 EQFDNLNAAHETSKLE--IEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQ 258
Q E + + + A+ +KLE K E KG E K L L ++ +
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 259 ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQEL---ESLKAVLEI 315
+ ++++ D ++ D + K E+K ++ E +M L+++L E + ++
Sbjct: 1663 D-FQRELEDARASRDEIFATAKENEKKAKSLEA------DLMQLQEDLAAAERARKQADL 1715
Query: 316 KNEKLHQQ-DIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMD-------KHMAISRQ 367
+ E+L ++ L L D L ++ + ++E EE + M+ K + Q
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 368 LSTEQAVLQESLEKESKVNKRLSMENEELLWKLH 401
LS E A + + +K ++L +N+EL KLH
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLH 1809
Score = 64.7 bits (156), Expect = 2e-10
Identities = 76/315 (24%), Positives = 141/315 (44%), Gaps = 40/315 (12%)
Query: 85 ILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKL 144
I +LK LA + +A + ++++ ALK+ + L + +L+ +L + K
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 145 EKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFD 204
EK + +L EA KTE E+ L T ++LR +E K L E+
Sbjct: 1145 EKQKRDLGEELEAL-------KTELEDTLDS--TATQQELRAKREQEVTVLKKALDEE-- 1193
Query: 205 NLNAAHETSKLEIEASH-------SEKLELLKKAYEASLSEIKKGHEIEKKSLED---LL 254
+HE E+ H +E+LE K+A +A+L + K+ E E L +L
Sbjct: 1194 --TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQTLEKENADLAGELRVL 1250
Query: 255 SEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLE 314
+ ++ +E + L+++ L K E R +A L N ++ L+ E+ES+ +
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGE-----RARAEL-NDKVHKLQNEVESVTGM-- 1302
Query: 315 IKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAV 374
L++ + K +K+ K V + ++ + + QE K + + RQL E+
Sbjct: 1303 -----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL---RQLEEERNS 1354
Query: 375 LQESLEKESKVNKRL 389
LQ+ L++E + + L
Sbjct: 1355 LQDQLDEEMEAKQNL 1369
Score = 62.8 bits (151), Expect = 6e-10
Identities = 72/349 (20%), Positives = 153/349 (43%), Gaps = 27/349 (7%)
Query: 70 ELTQYKTKCENQSGFILQLKQLLACGNTKFEA----LTVVIQHLLSEREEALKQHKTLSQ 125
+L +Y+T+ E++ + + L A K E L + + REEA+KQ + L
Sbjct: 1604 QLHEYETELEDER----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1659
Query: 126 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 185
++ + + EL A + +++ E + +A+ E + + E+ R
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKE---------NEKKAKSLEADLMQLQEDLAAAERAR 1710
Query: 186 DTYIEEAEKYKMQLQEQFDNLNAAH-ETSKLEIE-ASHSEKLELLKKAYEASLSEIKKGH 243
E E+ +L NA E +LE A E+LE + EA ++K
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770
Query: 244 EIEKKSLEDLLSEKQ--ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLK--NPQI 299
+ ++ +L +E+ + E L+ +N L KL E +++ K+ + +I
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1830
Query: 300 MYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN----EELK 355
LE+++E + + L Q+D KL ++ V++ + ++ K ++ ++LK
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 356 ARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGD 404
++++ S++++ + LQ L++ ++ N+ + E L KL G+
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1939
Score = 61.6 bits (148), Expect = 1e-09
Identities = 79/340 (23%), Positives = 142/340 (41%), Gaps = 42/340 (12%)
Query: 87 QLKQLLACGNTKFEALTVVIQHLLSEREEAL-----KQHKTLSQELVNLRGELVTASTTC 141
Q KQ + K EA +Q S+ E A K HK L E+ ++ G L A
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK-LQNEVESVTGMLNEAEGKA 1310
Query: 142 EKLEK----ARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKM 197
KL K ++LQ E +Q+ +K +L++ E L+D EE E K
Sbjct: 1311 IKLAKDVASLSSQLQDTQE-LLQEETRQKLNVSTKLRQL-EEERNSLQDQLDEEMEA-KQ 1367
Query: 198 QLQEQFDNLNAAHETSKLEIE--ASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLS 255
L+ LN SK +++ AS E LE KK ++ + + + +E EK + D L
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAAAYDKLE 1426
Query: 256 EKQESLEKQINDLKSENDALNEKLKSEEQKRRAREK--ANLKNPQIMYLEQE-------- 305
+ + L+++++DL + D + + + E+K+R ++ A KN Y ++
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486
Query: 306 ---------LESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKA 356
+L+ LE K E + +ME LV + + + ++ L+
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 357 RMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 396
+M+ ++ T+ L++ L+ RL + + L
Sbjct: 1547 QME-------EMKTQLEELEDELQATEDAKLRLEVNMQAL 1579
Score = 60.8 bits (146), Expect = 2e-09
Identities = 79/327 (24%), Positives = 152/327 (46%), Gaps = 31/327 (9%)
Query: 86 LQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLE 145
LQL+++ A K + L I + + + K+ K L + + +L L + L
Sbjct: 976 LQLEKVTA--EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 146 KARNELQT-VYEAFVQQHQAEKTERE-----NRLKEFYTREYEKLRDTYIEEAEKYKMQL 199
K +N+ ++ + E V+ + EK+ +E +L+ + +E++ D + AE KMQL
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE-LKMQL 1092
Query: 200 QEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEK-- 257
++ + L AA ++L+ E + +K LKK E +GH + + EDL SE+
Sbjct: 1093 AKKEEELQAA--LARLDDEIA--QKNNALKKIREL------EGHISDLQ--EDLDSERAA 1140
Query: 258 QESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKN 317
+ EKQ DL E +AL +L+ +++ K EQE+ LK L+ +
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR------EQEVTVLKKALD-EE 1193
Query: 318 EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQE 377
+ H+ ++ M+ +K L ++L++F++ L + L+ E VL +
Sbjct: 1194 TRSHEAQVQEMR-QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252
Query: 378 SLEKESKVNKRLSMENEELLWKLHNGD 404
+ ++ K+L + +EL K +G+
Sbjct: 1253 AKQEVEHKKKKLEAQVQELQSKCSDGE 1279
Score = 53.1 bits (126), Expect = 5e-07
Identities = 80/356 (22%), Positives = 156/356 (43%), Gaps = 47/356 (13%)
Query: 66 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ 125
+K +LT+ K + Q +L + A ++ +L E E L++ + Q
Sbjct: 887 QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ 946
Query: 126 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 185
+L R ++ E E+ E EA Q+ Q EK E ++K+ + +
Sbjct: 947 QLQAERKKMAQQMLDLE--EQLEEE-----EAARQKLQLEKVTAEAKIKKL--EDEILVM 997
Query: 186 DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEI 245
D + K + L+E+ +L T+ L E ++ L LK +E+ +SE++ +
Sbjct: 998 DDQNNKLSKERKLLEERISDL-----TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1052
Query: 246 EKKSLEDLLSEKQE------SLEKQINDLKSENDALNEKLKSEE---------------Q 284
E+KS ++L K++ +QI DL+++ L +L +E Q
Sbjct: 1053 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1112
Query: 285 KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKL 344
K A +K I L+++L+S +A K EK ++D+ E+L T L D L
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARN-KAEK-QKRDLG----EELEALKTELEDTL 1166
Query: 345 KRFQQENEELKARMDKHM-----AISRQLSTEQAVLQESLEKESKVNKRLSMENEE 395
+ +EL+A+ ++ + A+ + + +A +QE +K ++ + L+ + E+
Sbjct: 1167 DSTATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Score = 49.7 bits (117), Expect = 5e-06
Identities = 50/257 (19%), Positives = 122/257 (47%), Gaps = 16/257 (6%)
Query: 156 EAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKL 215
E ++ + +KT+ + E +E E+ EE + QLQ + + L A E ++
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-LYAEAEEMRV 918
Query: 216 EIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDAL 275
+ A E E+L + E +G +++ + + ++++ LE+Q+ + ++ L
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK--MAQQMLDLEEQLEEEEAARQKL 976
Query: 276 N-EKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLV 334
EK+ +E + ++ ++ + + Q L +E + L+ + L +++ K + KL
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 335 DNNTALVDKL-------KRFQQENEELKARMDKHMA-ISRQLSTEQAVLQE----SLEKE 382
+ + +++ +L ++ +QE E+LK +++ + Q++ QA + E +KE
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 383 SKVNKRLSMENEELLWK 399
++ L+ ++E+ K
Sbjct: 1097 EELQAALARLDDEIAQK 1113
Score = 38.9 bits (89), Expect = 0.009
Identities = 40/160 (25%), Positives = 67/160 (41%), Gaps = 14/160 (8%)
Query: 256 EKQESLEKQINDLKSENDALNEKLKSEEQKR-RAREKANLKNPQIMY---LEQELESLKA 311
E+ ++ E ++ K +LK EQK + E+ NL Q+ L E E ++
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 312 VLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTE 371
L K ++L E L + L ++ R QQ E K + + + QL E
Sbjct: 919 RLAAKKQELE---------EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 372 QAVLQE-SLEKESKVNKRLSMENEELLWKLHNGDLCSPKR 410
+A Q+ LEK + K +E+E L+ N L ++
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Score = 34.7 bits (78), Expect = 0.17
Identities = 41/170 (24%), Positives = 78/170 (45%), Gaps = 24/170 (14%)
Query: 111 SEREEALKQHKTLSQELVNLRGELVTA-STTCEKLEKARNELQTVYEAFVQQHQAEKTER 169
S R++ +Q+K L +L + G + + +T LE +L E V+Q EK
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL----EEQVEQEAREKQAA 1847
Query: 170 ENRLKEFYTREYEKLRDTYIEEAEKYKM--QLQEQFDNLNAAHETSKLEIEASHSEKLEL 227
LK+ + +KL++ ++ ++ KM Q +EQ + NA + K ++E + E +
Sbjct: 1848 TKSLKQ----KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1903
Query: 228 LKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNE 277
+ + K E+ D +E E++ +++N LKS+ NE
Sbjct: 1904 -------NANRRKLQREL------DEATESNEAMGREVNALKSKLRRGNE 1940
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 71.2 bits (173), Expect = 2e-12
Identities = 77/334 (23%), Positives = 139/334 (41%), Gaps = 43/334 (12%)
Query: 97 TKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYE 156
TK +L ++ L +EE + +K L E+ +L +LEK++ L+T
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET--- 1546
Query: 157 AFVQQHQAEKTERENRLKEFYTREYEKLR----------------DTYIEEAEKYKMQLQ 200
Q + KT+ E E E KLR E+ E+ + QLQ
Sbjct: 1547 ----QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 201 EQFDNLNAAHETSKLE--IEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQ 258
Q E + + + A+ +KLE K E KG E K L L ++ +
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 259 ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQEL---ESLKAVLEI 315
+ ++++ D ++ D + K E+K ++ E +M L+++L E + ++
Sbjct: 1663 D-FQRELEDARASRDEIFATAKENEKKAKSLEA------DLMQLQEDLAAAERARKQADL 1715
Query: 316 KNEKLHQQ-DIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMD-------KHMAISRQ 367
+ E+L ++ L L D L ++ + ++E EE + M+ K + Q
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 368 LSTEQAVLQESLEKESKVNKRLSMENEELLWKLH 401
LS E A + + +K ++L +N+EL KLH
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLH 1809
Score = 64.7 bits (156), Expect = 2e-10
Identities = 76/315 (24%), Positives = 141/315 (44%), Gaps = 40/315 (12%)
Query: 85 ILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKL 144
I +LK LA + +A + ++++ ALK+ + L + +L+ +L + K
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 145 EKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFD 204
EK + +L EA KTE E+ L T ++LR +E K L E+
Sbjct: 1145 EKQKRDLGEELEAL-------KTELEDTLDS--TATQQELRAKREQEVTVLKKALDEE-- 1193
Query: 205 NLNAAHETSKLEIEASH-------SEKLELLKKAYEASLSEIKKGHEIEKKSLED---LL 254
+HE E+ H +E+LE K+A +A+L + K+ E E L +L
Sbjct: 1194 --TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQTLEKENADLAGELRVL 1250
Query: 255 SEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLE 314
+ ++ +E + L+++ L K E R +A L N ++ L+ E+ES+ +
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGE-----RARAEL-NDKVHKLQNEVESVTGM-- 1302
Query: 315 IKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAV 374
L++ + K +K+ K V + ++ + + QE K + + RQL E+
Sbjct: 1303 -----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL---RQLEEERNS 1354
Query: 375 LQESLEKESKVNKRL 389
LQ+ L++E + + L
Sbjct: 1355 LQDQLDEEMEAKQNL 1369
Score = 61.6 bits (148), Expect = 1e-09
Identities = 79/340 (23%), Positives = 142/340 (41%), Gaps = 42/340 (12%)
Query: 87 QLKQLLACGNTKFEALTVVIQHLLSEREEAL-----KQHKTLSQELVNLRGELVTASTTC 141
Q KQ + K EA +Q S+ E A K HK L E+ ++ G L A
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK-LQNEVESVTGMLNEAEGKA 1310
Query: 142 EKLEK----ARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKM 197
KL K ++LQ E +Q+ +K +L++ E L+D EE E K
Sbjct: 1311 IKLAKDVASLSSQLQDTQE-LLQEETRQKLNVSTKLRQL-EEERNSLQDQLDEEMEA-KQ 1367
Query: 198 QLQEQFDNLNAAHETSKLEIE--ASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLS 255
L+ LN SK +++ AS E LE KK ++ + + + +E EK + D L
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAAAYDKLE 1426
Query: 256 EKQESLEKQINDLKSENDALNEKLKSEEQKRRAREK--ANLKNPQIMYLEQE-------- 305
+ + L+++++DL + D + + + E+K+R ++ A KN Y ++
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486
Query: 306 ---------LESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKA 356
+L+ LE K E + +ME LV + + + ++ L+
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 357 RMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 396
+M+ ++ T+ L++ L+ RL + + L
Sbjct: 1547 QME-------EMKTQLEELEDELQATEDAKLRLEVNMQAL 1579
Score = 60.8 bits (146), Expect = 2e-09
Identities = 79/327 (24%), Positives = 152/327 (46%), Gaps = 31/327 (9%)
Query: 86 LQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLE 145
LQL+++ A K + L I + + + K+ K L + + +L L + L
Sbjct: 976 LQLEKVTA--EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 146 KARNELQT-VYEAFVQQHQAEKTERE-----NRLKEFYTREYEKLRDTYIEEAEKYKMQL 199
K +N+ ++ + E V+ + EK+ +E +L+ + +E++ D + AE KMQL
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE-LKMQL 1092
Query: 200 QEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEK-- 257
++ + L AA ++L+ E + +K LKK E +GH + + EDL SE+
Sbjct: 1093 AKKEEELQAA--LARLDDEIA--QKNNALKKIREL------EGHISDLQ--EDLDSERAA 1140
Query: 258 QESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKN 317
+ EKQ DL E +AL +L+ +++ K EQE+ LK L+ +
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR------EQEVTVLKKALD-EE 1193
Query: 318 EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQE 377
+ H+ ++ M+ +K L ++L++F++ L + L+ E VL +
Sbjct: 1194 TRSHEAQVQEMR-QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252
Query: 378 SLEKESKVNKRLSMENEELLWKLHNGD 404
+ ++ K+L + +EL K +G+
Sbjct: 1253 AKQEVEHKKKKLEAQVQELQSKCSDGE 1279
Score = 60.1 bits (144), Expect = 4e-09
Identities = 71/345 (20%), Positives = 151/345 (43%), Gaps = 27/345 (7%)
Query: 70 ELTQYKTKCENQSGFILQLKQLLACGNTKFEA----LTVVIQHLLSEREEALKQHKTLSQ 125
+L +Y+T+ E++ + + L A K E L + + REEA+KQ + L
Sbjct: 1604 QLHEYETELEDER----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1659
Query: 126 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 185
++ + + EL A + +++ E + +A+ E + + E+ R
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKE---------NEKKAKSLEADLMQLQEDLAAAERAR 1710
Query: 186 DTYIEEAEKYKMQLQEQFDNLNAAH-ETSKLEIE-ASHSEKLELLKKAYEASLSEIKKGH 243
E E+ +L NA E +LE A E+LE + EA ++K
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770
Query: 244 EIEKKSLEDLLSEKQ--ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLK--NPQI 299
+ ++ +L +E+ + E L+ +N L KL E +++ K+ + +I
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1830
Query: 300 MYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN----EELK 355
LE+++E + + L Q+D KL ++ V++ + ++ K ++ ++LK
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 356 ARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKL 400
++++ S++++ + LQ L++ ++ N+ + E L KL
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 53.1 bits (126), Expect = 5e-07
Identities = 80/356 (22%), Positives = 156/356 (43%), Gaps = 47/356 (13%)
Query: 66 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ 125
+K +LT+ K + Q +L + A ++ +L E E L++ + Q
Sbjct: 887 QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ 946
Query: 126 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 185
+L R ++ E E+ E EA Q+ Q EK E ++K+ + +
Sbjct: 947 QLQAERKKMAQQMLDLE--EQLEEE-----EAARQKLQLEKVTAEAKIKKL--EDEILVM 997
Query: 186 DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEI 245
D + K + L+E+ +L T+ L E ++ L LK +E+ +SE++ +
Sbjct: 998 DDQNNKLSKERKLLEERISDL-----TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1052
Query: 246 EKKSLEDLLSEKQE------SLEKQINDLKSENDALNEKLKSEE---------------Q 284
E+KS ++L K++ +QI DL+++ L +L +E Q
Sbjct: 1053 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1112
Query: 285 KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKL 344
K A +K I L+++L+S +A K EK ++D+ E+L T L D L
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARN-KAEK-QKRDLG----EELEALKTELEDTL 1166
Query: 345 KRFQQENEELKARMDKHM-----AISRQLSTEQAVLQESLEKESKVNKRLSMENEE 395
+ +EL+A+ ++ + A+ + + +A +QE +K ++ + L+ + E+
Sbjct: 1167 DSTATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Score = 49.7 bits (117), Expect = 5e-06
Identities = 50/257 (19%), Positives = 122/257 (47%), Gaps = 16/257 (6%)
Query: 156 EAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKL 215
E ++ + +KT+ + E +E E+ EE + QLQ + + L A E ++
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-LYAEAEEMRV 918
Query: 216 EIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDAL 275
+ A E E+L + E +G +++ + + ++++ LE+Q+ + ++ L
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK--MAQQMLDLEEQLEEEEAARQKL 976
Query: 276 N-EKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLV 334
EK+ +E + ++ ++ + + Q L +E + L+ + L +++ K + KL
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 335 DNNTALVDKL-------KRFQQENEELKARMDKHMA-ISRQLSTEQAVLQE----SLEKE 382
+ + +++ +L ++ +QE E+LK +++ + Q++ QA + E +KE
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 383 SKVNKRLSMENEELLWK 399
++ L+ ++E+ K
Sbjct: 1097 EELQAALARLDDEIAQK 1113
Score = 38.9 bits (89), Expect = 0.009
Identities = 40/160 (25%), Positives = 67/160 (41%), Gaps = 14/160 (8%)
Query: 256 EKQESLEKQINDLKSENDALNEKLKSEEQKR-RAREKANLKNPQIMY---LEQELESLKA 311
E+ ++ E ++ K +LK EQK + E+ NL Q+ L E E ++
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 312 VLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTE 371
L K ++L E L + L ++ R QQ E K + + + QL E
Sbjct: 919 RLAAKKQELE---------EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 372 QAVLQE-SLEKESKVNKRLSMENEELLWKLHNGDLCSPKR 410
+A Q+ LEK + K +E+E L+ N L ++
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 71.2 bits (173), Expect = 2e-12
Identities = 77/334 (23%), Positives = 139/334 (41%), Gaps = 43/334 (12%)
Query: 97 TKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYE 156
TK +L ++ L +EE + +K L E+ +L +LEK++ L+T
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET--- 1539
Query: 157 AFVQQHQAEKTERENRLKEFYTREYEKLR----------------DTYIEEAEKYKMQLQ 200
Q + KT+ E E E KLR E+ E+ + QLQ
Sbjct: 1540 ----QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 201 EQFDNLNAAHETSKLE--IEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQ 258
Q E + + + A+ +KLE K E KG E K L L ++ +
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 259 ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQEL---ESLKAVLEI 315
+ ++++ D ++ D + K E+K ++ E +M L+++L E + ++
Sbjct: 1656 D-FQRELEDARASRDEIFATAKENEKKAKSLEA------DLMQLQEDLAAAERARKQADL 1708
Query: 316 KNEKLHQQ-DIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMD-------KHMAISRQ 367
+ E+L ++ L L D L ++ + ++E EE + M+ K + Q
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 368 LSTEQAVLQESLEKESKVNKRLSMENEELLWKLH 401
LS E A + + +K ++L +N+EL KLH
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLH 1802
Score = 64.7 bits (156), Expect = 2e-10
Identities = 76/315 (24%), Positives = 141/315 (44%), Gaps = 40/315 (12%)
Query: 85 ILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKL 144
I +LK LA + +A + ++++ ALK+ + L + +L+ +L + K
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 145 EKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFD 204
EK + +L EA KTE E+ L T ++LR +E K L E+
Sbjct: 1138 EKQKRDLGEELEAL-------KTELEDTLDS--TATQQELRAKREQEVTVLKKALDEE-- 1186
Query: 205 NLNAAHETSKLEIEASH-------SEKLELLKKAYEASLSEIKKGHEIEKKSLED---LL 254
+HE E+ H +E+LE K+A +A+L + K+ E E L +L
Sbjct: 1187 --TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQTLEKENADLAGELRVL 1243
Query: 255 SEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLE 314
+ ++ +E + L+++ L K E R +A L N ++ L+ E+ES+ +
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGE-----RARAEL-NDKVHKLQNEVESVTGM-- 1295
Query: 315 IKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAV 374
L++ + K +K+ K V + ++ + + QE K + + RQL E+
Sbjct: 1296 -----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL---RQLEEERNS 1347
Query: 375 LQESLEKESKVNKRL 389
LQ+ L++E + + L
Sbjct: 1348 LQDQLDEEMEAKQNL 1362
Score = 61.6 bits (148), Expect = 1e-09
Identities = 79/340 (23%), Positives = 142/340 (41%), Gaps = 42/340 (12%)
Query: 87 QLKQLLACGNTKFEALTVVIQHLLSEREEAL-----KQHKTLSQELVNLRGELVTASTTC 141
Q KQ + K EA +Q S+ E A K HK L E+ ++ G L A
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK-LQNEVESVTGMLNEAEGKA 1303
Query: 142 EKLEK----ARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKM 197
KL K ++LQ E +Q+ +K +L++ E L+D EE E K
Sbjct: 1304 IKLAKDVASLSSQLQDTQE-LLQEETRQKLNVSTKLRQL-EEERNSLQDQLDEEMEA-KQ 1360
Query: 198 QLQEQFDNLNAAHETSKLEIE--ASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLS 255
L+ LN SK +++ AS E LE KK ++ + + + +E EK + D L
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAAAYDKLE 1419
Query: 256 EKQESLEKQINDLKSENDALNEKLKSEEQKRRAREK--ANLKNPQIMYLEQE-------- 305
+ + L+++++DL + D + + + E+K+R ++ A KN Y ++
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479
Query: 306 ---------LESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKA 356
+L+ LE K E + +ME LV + + + ++ L+
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 357 RMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 396
+M+ ++ T+ L++ L+ RL + + L
Sbjct: 1540 QME-------EMKTQLEELEDELQATEDAKLRLEVNMQAL 1572
Score = 60.8 bits (146), Expect = 2e-09
Identities = 79/327 (24%), Positives = 152/327 (46%), Gaps = 31/327 (9%)
Query: 86 LQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLE 145
LQL+++ A K + L I + + + K+ K L + + +L L + L
Sbjct: 969 LQLEKVTA--EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 146 KARNELQT-VYEAFVQQHQAEKTERE-----NRLKEFYTREYEKLRDTYIEEAEKYKMQL 199
K +N+ ++ + E V+ + EK+ +E +L+ + +E++ D + AE KMQL
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE-LKMQL 1085
Query: 200 QEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEK-- 257
++ + L AA ++L+ E + +K LKK E +GH + + EDL SE+
Sbjct: 1086 AKKEEELQAA--LARLDDEIA--QKNNALKKIREL------EGHISDLQ--EDLDSERAA 1133
Query: 258 QESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKN 317
+ EKQ DL E +AL +L+ +++ K EQE+ LK L+ +
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR------EQEVTVLKKALD-EE 1186
Query: 318 EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQE 377
+ H+ ++ M+ +K L ++L++F++ L + L+ E VL +
Sbjct: 1187 TRSHEAQVQEMR-QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245
Query: 378 SLEKESKVNKRLSMENEELLWKLHNGD 404
+ ++ K+L + +EL K +G+
Sbjct: 1246 AKQEVEHKKKKLEAQVQELQSKCSDGE 1272
Score = 60.1 bits (144), Expect = 4e-09
Identities = 71/345 (20%), Positives = 151/345 (43%), Gaps = 27/345 (7%)
Query: 70 ELTQYKTKCENQSGFILQLKQLLACGNTKFEA----LTVVIQHLLSEREEALKQHKTLSQ 125
+L +Y+T+ E++ + + L A K E L + + REEA+KQ + L
Sbjct: 1597 QLHEYETELEDER----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652
Query: 126 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 185
++ + + EL A + +++ E + +A+ E + + E+ R
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKE---------NEKKAKSLEADLMQLQEDLAAAERAR 1703
Query: 186 DTYIEEAEKYKMQLQEQFDNLNAAH-ETSKLEIE-ASHSEKLELLKKAYEASLSEIKKGH 243
E E+ +L NA E +LE A E+LE + EA ++K
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763
Query: 244 EIEKKSLEDLLSEKQ--ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLK--NPQI 299
+ ++ +L +E+ + E L+ +N L KL E +++ K+ + +I
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1823
Query: 300 MYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN----EELK 355
LE+++E + + L Q+D KL ++ V++ + ++ K ++ ++LK
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 356 ARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKL 400
++++ S++++ + LQ L++ ++ N+ + E L KL
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 53.1 bits (126), Expect = 5e-07
Identities = 80/356 (22%), Positives = 156/356 (43%), Gaps = 47/356 (13%)
Query: 66 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ 125
+K +LT+ K + Q +L + A ++ +L E E L++ + Q
Sbjct: 880 QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ 939
Query: 126 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 185
+L R ++ E E+ E EA Q+ Q EK E ++K+ + +
Sbjct: 940 QLQAERKKMAQQMLDLE--EQLEEE-----EAARQKLQLEKVTAEAKIKKL--EDEILVM 990
Query: 186 DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEI 245
D + K + L+E+ +L T+ L E ++ L LK +E+ +SE++ +
Sbjct: 991 DDQNNKLSKERKLLEERISDL-----TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1045
Query: 246 EKKSLEDLLSEKQE------SLEKQINDLKSENDALNEKLKSEE---------------Q 284
E+KS ++L K++ +QI DL+++ L +L +E Q
Sbjct: 1046 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1105
Query: 285 KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKL 344
K A +K I L+++L+S +A K EK ++D+ E+L T L D L
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARN-KAEK-QKRDLG----EELEALKTELEDTL 1159
Query: 345 KRFQQENEELKARMDKHM-----AISRQLSTEQAVLQESLEKESKVNKRLSMENEE 395
+ +EL+A+ ++ + A+ + + +A +QE +K ++ + L+ + E+
Sbjct: 1160 DSTATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Score = 49.7 bits (117), Expect = 5e-06
Identities = 50/257 (19%), Positives = 122/257 (47%), Gaps = 16/257 (6%)
Query: 156 EAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKL 215
E ++ + +KT+ + E +E E+ EE + QLQ + + L A E ++
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-LYAEAEEMRV 911
Query: 216 EIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDAL 275
+ A E E+L + E +G +++ + + ++++ LE+Q+ + ++ L
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK--MAQQMLDLEEQLEEEEAARQKL 969
Query: 276 N-EKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLV 334
EK+ +E + ++ ++ + + Q L +E + L+ + L +++ K + KL
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 335 DNNTALVDKL-------KRFQQENEELKARMDKHMA-ISRQLSTEQAVLQE----SLEKE 382
+ + +++ +L ++ +QE E+LK +++ + Q++ QA + E +KE
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 383 SKVNKRLSMENEELLWK 399
++ L+ ++E+ K
Sbjct: 1090 EELQAALARLDDEIAQK 1106
Score = 38.9 bits (89), Expect = 0.009
Identities = 40/160 (25%), Positives = 67/160 (41%), Gaps = 14/160 (8%)
Query: 256 EKQESLEKQINDLKSENDALNEKLKSEEQKR-RAREKANLKNPQIMY---LEQELESLKA 311
E+ ++ E ++ K +LK EQK + E+ NL Q+ L E E ++
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 312 VLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTE 371
L K ++L E L + L ++ R QQ E K + + + QL E
Sbjct: 912 RLAAKKQELE---------EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 372 QAVLQE-SLEKESKVNKRLSMENEELLWKLHNGDLCSPKR 410
+A Q+ LEK + K +E+E L+ N L ++
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 70.9 bits (172), Expect = 2e-12
Identities = 88/357 (24%), Positives = 167/357 (46%), Gaps = 51/357 (14%)
Query: 62 ALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHK 121
AL + L++ Q K EN + L Q LA + E L IQ L +RE +
Sbjct: 1404 ALQEQGELKVAQGKALQEN----LALLTQTLAEREEEVETLRGQIQELEKQREMQKAALE 1459
Query: 122 TLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREY 181
LS +L E+ ++LEK R+ L+ + A ++ Q +RE RE
Sbjct: 1460 LLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ------IREL 1513
Query: 182 EKLRDTYIEEAEKYKMQLQEQFDNLNAAH-------------ETSKLEIEASHSEKLELL 228
EK R+T E ++L+++ + + E LE+E +H K+E
Sbjct: 1514 EKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENH-HKMECQ 1572
Query: 229 KKAYEASLSEIKKGHEIEKKSLEDL---LSEKQESLE---KQINDLKSENDALNEKLKSE 282
+K + E++ E ++ +L L L E+ + L+ QI+DL+S + L +L+
Sbjct: 1573 QKL----IKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQER 1628
Query: 283 EQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVD 342
+Q+ +++ + QI L+++ E L LE ++++L Q ++ +E D T
Sbjct: 1629 DQEVKSQRE------QIEELQRQKEHLTQDLERRDQELMLQKERIQVLE---DQRTR--- 1676
Query: 343 KLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNK--RLSMENEELL 397
+ K +++ E++K + + R+L+T++ ++QE E+ +K R S+E+ +L+
Sbjct: 1677 QTKILEEDLEQIKLSLRER---GRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI 1730
Score = 67.4 bits (163), Expect = 2e-11
Identities = 81/331 (24%), Positives = 139/331 (41%), Gaps = 59/331 (17%)
Query: 100 EALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFV 159
+AL +Q L ER+ TL+ + V+L+GE+ + S E L+KAR EL+ E
Sbjct: 431 KALRQRLQKLTGERD-------TLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLE 483
Query: 160 QQ-----------------HQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQ 202
Q+ Q +K E++ L RE E+L++ + K L E
Sbjct: 484 QEAWRLRRVNVELQLQGDSAQGQKEEQQEEL-HLAVRERERLQEMLMGLEAKQSESLSEL 542
Query: 203 FDNLNAAHETSKLEIEASHSEKLEL---LKKAYEASLSEIKKGHEIEKKSLEDL------ 253
L A E+S LE E E+ E+ L +A E S++E+ K + DL
Sbjct: 543 I-TLREALESSHLEGELLRQEQTEVTAALARA-EQSIAELSSSENTLKTEVADLRAAAVK 600
Query: 254 -------LSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQEL 306
L+ + L +Q+ L+ EN ++ ++++ EQ R A + E
Sbjct: 601 LSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNA----------LQVDLAEA 650
Query: 307 ESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISR 366
E + L KN L Q ++K + L L+ Q+E EE++ ++ +
Sbjct: 651 EKRREALWEKNTHLEAQ------LQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQE 704
Query: 367 QLSTEQAVLQESLEKESKVNKRLSMENEELL 397
+T+ L + +++ +V R E E L+
Sbjct: 705 AATTQLEQLHQEAKRQEEVLARAVQEKEALV 735
Score = 61.2 bits (147), Expect = 2e-09
Identities = 75/304 (24%), Positives = 141/304 (46%), Gaps = 25/304 (8%)
Query: 69 LELTQYKTKCENQ-SGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQEL 127
LEL +++ E + QL Q G T E + +++ E ++ ++ Q+
Sbjct: 813 LELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQ- 871
Query: 128 VNLRGELVTASTTCEK----LEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEK 183
EL A + E+ LE E QT EA Q + E+T+ E+ L + E EK
Sbjct: 872 -----ELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQL-ETEK 925
Query: 184 LRDTYIE---EAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK 240
R + +E + +K +Q + L + KL+ + + L++A + L E
Sbjct: 926 ERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEA-QRELKEAA 984
Query: 241 KGHEIEKKSLED----LLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKN 296
+ H + +L++ LL +K + L+KQ+ DLKS+ A ++ + EQ+ +EK +
Sbjct: 985 RQHRDDLAALQEESSSLLQDKMD-LQKQVEDLKSQLVAQDDSQRLVEQE--VQEKLR-ET 1040
Query: 297 PQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNN-TALVDKLKRFQQENEELK 355
+ +++ELE KA L + + Q+ + L + + + +AL ++ Q E +EL
Sbjct: 1041 QEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELS 1100
Query: 356 ARMD 359
A+M+
Sbjct: 1101 AQME 1104
Score = 49.7 bits (117), Expect = 5e-06
Identities = 64/318 (20%), Positives = 142/318 (44%), Gaps = 21/318 (6%)
Query: 81 QSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTT 140
Q QL+QL + E L +Q E+E +++ L L + + +
Sbjct: 703 QEAATTQLEQLHQEAKRQEEVLARAVQ----EKEALVREKAALEVRLQAVERDRQDLAEQ 758
Query: 141 CEKLEKARNELQT-VYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQL 199
+ L A+ L++ ++EA Q E T+ + E + + ++ E K++L
Sbjct: 759 LQGLSSAKELLESSLFEAQQQNSVIEVTKGQ---LEVQIQTVTQAKEVIQGEVRCLKLEL 815
Query: 200 QEQFDNLNAAHETSKLEIEASHSE---KLELLKKAYEASLSEIKKGHEIEKKSLEDLLSE 256
+ + + ++ + E LE K A+E ++++++ E E+ + L++
Sbjct: 816 DTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAK 875
Query: 257 KQESLEKQINDLK---SENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVL 313
ESLE++ +L+ E E ++++ ++ R + ++ L Q+ ++ + L+ +L
Sbjct: 876 ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLL 935
Query: 314 EIKNE--KLHQQDIKL---MKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQL 368
+ + E QQ +L MK++KL + T + + + Q+ ELK +H L
Sbjct: 936 QTQKELADASQQLERLRQDMKVQKLKEQETTGILQ-TQLQEAQRELKEAARQHRDDLAAL 994
Query: 369 STE-QAVLQESLEKESKV 385
E ++LQ+ ++ + +V
Sbjct: 995 QEESSSLLQDKMDLQKQV 1012
Score = 49.7 bits (117), Expect = 5e-06
Identities = 86/413 (20%), Positives = 168/413 (40%), Gaps = 58/413 (14%)
Query: 70 ELTQYKTKCENQ-SGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELV 128
EL + K + E Q G ++ + + + + + V+ Q L RE+ + ++L +L
Sbjct: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLD 1806
Query: 129 NLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTY 188
+ L E L++ + + Q E ++ A + E R E L+D +
Sbjct: 1807 EAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGE-LQD-H 1864
Query: 189 IEEAEKYKMQLQEQFDNLNAAHET-SKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEK 247
E+A + + +L + + A E L E+ EK L A + +E + HE+E
Sbjct: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALL---ALQQQCAEQAQEHEVET 1921
Query: 248 KSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKA----------NLKNP 297
++L+D + Q L+++ +L++ A ++ + +E+ RAR +A L+
Sbjct: 1922 RALQDSWLQAQAVLKERDQELEALR-AESQSSRHQEEAARARAEALQEALGKAHAALQGK 1980
Query: 298 QIMYLEQ-----ELES------------------LKAVLEIKNEKLHQQDIKLMKMEKLV 334
+ LEQ LE+ L+ L I+ ++ QD++ + + +
Sbjct: 1981 EQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQL 2040
Query: 335 DNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKE--------SKVN 386
A D+ R QQE E+L + + +Q + QE E+E ++
Sbjct: 2041 QQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQ 2100
Query: 387 KRLSMENEELLWKLHNGDLCSPKRSPTSSAIP---LQSPRNSGSFPSPSISPR 436
L+ + +E+L +L ++ A+P SP S S+ PR
Sbjct: 2101 LTLAQKEQEIL------ELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPR 2147
Score = 43.5 bits (101), Expect = 4e-04
Identities = 61/278 (21%), Positives = 121/278 (43%), Gaps = 24/278 (8%)
Query: 42 EKSRQKNPRSLC-IQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFE 100
E+ R + +LC +Q +T + + +TL TQ + +Q + +L+Q + K +
Sbjct: 906 EEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQ--LERLRQDMKVQKLKEQ 963
Query: 101 ALTVVIQHLLSERE----EALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYE 156
T ++Q L E + EA +QH+ +L L+ E + L+K +L++
Sbjct: 964 ETTGILQTQLQEAQRELKEAARQHR---DDLAALQEESSSLLQDKMDLQKQVEDLKSQLV 1020
Query: 157 AFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLE 216
A + + E + +L+E T+EY +++ E + L E+ L E +
Sbjct: 1021 AQDDSQRLVEQEVQEKLRE--TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIR 1078
Query: 217 IEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALN 276
++L L++ + + +G + E + +LL +QE EK+ + L E L
Sbjct: 1079 -----QQELSALRQDMQEA-----QGEQKELSAQMELL--RQEVKEKEADFLAQEAQLLE 1126
Query: 277 EKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLE 314
E S +++ R + + L+ L S ++ LE
Sbjct: 1127 ELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLE 1164
Score = 42.7 bits (99), Expect = 6e-04
Identities = 59/280 (21%), Positives = 125/280 (44%), Gaps = 43/280 (15%)
Query: 131 RGELVTASTTCEKLEKARNEL-QTVYEAFVQQHQAEKTERENRLKEFYT-REYEKLR-DT 187
RG L+TA + E + A ++L Q +++ QQ + ++ +L+E T E EK + T
Sbjct: 1229 RGPLLTA-LSAEAVASALHKLHQDLWKT--QQTRDVLRDQVQKLEERLTDTEAEKSQVHT 1285
Query: 188 YIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEK 247
+++ ++ Q QE+ + + E+ H L + A L + E
Sbjct: 1286 ELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRM------EA 1339
Query: 248 KSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELE 307
+ +LL +E+L Q+ E L++ + RA+ A LE++L
Sbjct: 1340 QGERELLQAAKENLTAQV-----------EHLQAAVVEARAQASA------AGILEEDLR 1382
Query: 308 SLKAVLEIKNEKL-----------HQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKA 356
+ ++ L++KNE++ Q ++K+ + + L +N L L ++E E L+
Sbjct: 1383 TARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRG 1442
Query: 357 RMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 396
++ + + +Q ++A L+ K N+ + ++ E++
Sbjct: 1443 QIQE---LEKQREMQKAALELLSLDLKKRNQEVDLQQEQI 1479
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 69.7 bits (169), Expect = 5e-12
Identities = 86/348 (24%), Positives = 156/348 (44%), Gaps = 60/348 (17%)
Query: 61 DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH 120
D EKTL ++ + + ++ I +L+Q L C + + + L Q + ERE +Q
Sbjct: 1925 DGYADEKTL----FERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980
Query: 121 KTLSQELVNLRGELV--TASTTCEKLE------KARNELQTVYEA-----------FVQQ 161
+ + E + +L+ T EKLE K R++LQ +A F++
Sbjct: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040
Query: 162 HQAEKTE-----RENRLKEFYTREYEKL-----------RDTYIEEAEKYKMQLQ--EQF 203
Q + TE ++N+ E + K RD + +E +K + QL+ +F
Sbjct: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
Query: 204 DNLNAAHETSKLEIEASHSEKL-----ELLKKAYEASLSEIKKGHEIEK-----KSLEDL 253
++ H+T ++E A+H ++ ELL + ++ EIEK + LE
Sbjct: 2101 QPISE-HQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQA 2159
Query: 254 LSEKQESLEKQINDLKSENDA-LNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAV 312
L ++ +K + D K +L E Q + R+ + K +I LE++LE +
Sbjct: 2160 LLVSADTFQK-VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
Query: 313 LEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK 360
LE KNE++ Q ++L +K ++ T +L+ +QEN+ K M+K
Sbjct: 2219 LENKNEEVQQLHMQLEIQKK--ESTT----RLQELEQENKLFKDDMEK 2260
Score = 63.5 bits (153), Expect = 4e-10
Identities = 82/370 (22%), Positives = 160/370 (43%), Gaps = 46/370 (12%)
Query: 67 KTLELTQYKTKCENQSGFIL--------QLKQLLACGNTKFEALTVVIQHLLSEREEALK 118
K + K K + + G IL QL+ L+ + E + Q + + + +
Sbjct: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560
Query: 119 QHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYT 178
HK+LS + +L+ E+V+AS + ++LE T Y+ ++ + EK +R+ E
Sbjct: 561 AHKSLST-VEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQE 619
Query: 179 REYEKLRD----TYIEEAEKYKMQLQEQF--------DNLNAAHETS--------KLEIE 218
E E+LR ++ EE K K L+ + DNL ++ +IE
Sbjct: 620 AELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIE 679
Query: 219 ASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEK 278
EK L+ K + L EI K +++ + L++ K E + QIN+L+ E + L ++
Sbjct: 680 TMQFEKDNLITKQNQLIL-EISKLKDLQ----QSLVNSKSEEMTLQINELQKEIEILRQE 734
Query: 279 LKS----EEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKL- 333
K E++ + + K L Q+ E +L+ A LE +N L + L M K+
Sbjct: 735 EKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794
Query: 334 ----VDNNTALVDKLKRFQQEN---EELKARMDKHMAISRQLSTEQAVLQESLEKESKVN 386
+ +D +K +++ +E++ ++++ + +Q +++ S
Sbjct: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854
Query: 387 KRLSMENEEL 396
K + +EL
Sbjct: 855 KNFEVNYQEL 864
Score = 53.1 bits (126), Expect = 5e-07
Identities = 66/327 (20%), Positives = 143/327 (43%), Gaps = 38/327 (11%)
Query: 100 EALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFV 159
+ L + Q L + H + + +L+ + +++T E+ + + Q E F
Sbjct: 236 QKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFT 295
Query: 160 QQ-------------HQAEKTERENRLKEFYTRE--YEKLRDTYIEE------------- 191
Q Q +K E N+ +E +E E+L IEE
Sbjct: 296 MQISFLQEKIKVYEMEQDKKVENSNK-EEIQEKETIIEELNTKIIEEEKKTLELKDKLTT 354
Query: 192 AEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLK--KAYEASLSEIKKGHEIEKKS 249
A+K +LQEQ N + KLE+ S ++ + + K ++ E++K + + +
Sbjct: 355 ADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF 414
Query: 250 LEDLLSEKQESLEKQINDLKSENDAL-NEKLKSEEQKRRAREKANLKNPQIMYLEQELES 308
D++ ++ ++++ L++E D + +++ +Q+ + A ++ + + + E+E+
Sbjct: 415 ETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRH-KGEMEN 473
Query: 309 LKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQL 368
A+ N +++ IKLM + + + N L D + ++ EEL +++ A+ RQL
Sbjct: 474 --ALRSYSNITVNEDQIKLMNVA-INELNIKLQDTNSQKEKLKEELGLILEEKCALQRQL 530
Query: 369 STEQAVLQESLEKESKVNKRLSMENEE 395
E V + S +E R ++ +E
Sbjct: 531 --EDLVEELSFSREQIQRARQTIAEQE 555
Score = 50.1 bits (118), Expect = 4e-06
Identities = 70/297 (23%), Positives = 142/297 (47%), Gaps = 39/297 (13%)
Query: 110 LSEREEALKQHKT--LSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKT 167
+ E E A KQH+ L++EL +R VT T E L++ + +EA ++Q T
Sbjct: 159 MMESELAGKQHEIEELNRELEEMR---VTYGT--EGLQQLQE-----FEAAIKQRDGIIT 208
Query: 168 ERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLEL 227
+ L++ + E +R+ ++E E+ +LQ QF L A+ ET + ++HS
Sbjct: 209 QLTANLQQARREKDETMRE-FLELTEQ-SQKLQIQFQQLQAS-ETLR---NSTHSSTAAD 262
Query: 228 LKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRR 287
L +A + L+ H+ + + + LL + Q+ E D + L EK+K E ++
Sbjct: 263 LLQAKQQILT-----HQQQLEEQDHLLEDYQKKKE----DFTMQISFLQEKIKVYEMEQD 313
Query: 288 AREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKM-EKLVDNNTALVDKLKR 346
+ + + K +E++ + ++E N K+ +++ K +++ +KL + L + ++
Sbjct: 314 KKVENSNK--------EEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQ 365
Query: 347 FQQENEE---LKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKL 400
Q+N+E +K + RQ S E L ++E+ K N + S +++ ++
Sbjct: 366 IVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 422
Score = 47.8 bits (112), Expect = 2e-05
Identities = 61/285 (21%), Positives = 128/285 (44%), Gaps = 32/285 (11%)
Query: 112 EREEALKQHKTLSQEL---VNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTE 168
E E+LK + L + L R +L + E + + +T++E +Q EKT+
Sbjct: 1888 EATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQ----EKTD 1943
Query: 169 RENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLE-- 226
+RL++ +L +E E + Q+QE+ + L+ E K E + L+
Sbjct: 1944 IIDRLEQELLCASNRL-----QELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQET 1998
Query: 227 --LLKKAYEASLSEIKKGHEIEKK------SLEDLLS---EKQESLEKQINDLKSENDAL 275
L+K+ E K +++K+ +E+ +S E ++ ++ DL+ +N AL
Sbjct: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQAL 2058
Query: 276 NEKLKS-----EEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKM 330
++L+ +EQ + ++ +I LEQ+L+ + I + + + +
Sbjct: 2059 EKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL 2118
Query: 331 EKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVL 375
++ D + L+ ++ Q++ +E ++K R+L EQA+L
Sbjct: 2119 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVREL--EQALL 2161
Score = 44.7 bits (104), Expect = 2e-04
Identities = 65/325 (20%), Positives = 139/325 (42%), Gaps = 28/325 (8%)
Query: 91 LLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNE 150
LL C + + V Q + ++A ++L E+ L ++ T ++ +++
Sbjct: 3060 LLNCLEQRIQEQGVEYQAAMECLQKA--DRRSLLSEIQALHAQMNGRKITLKREQESEKP 3117
Query: 151 LQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAH 210
Q + E +QQ Q++ E + L R E E+ KM + E L +
Sbjct: 3118 SQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ-----EQLSSEKMVVAE----LKSEL 3168
Query: 211 ETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQE-------SLEK 263
+KLE+E + + + LK+ EA E+K + E L D L+ +Q+ +LEK
Sbjct: 3169 AQTKLELETTLKAQHKHLKEL-EAFRLEVKDKTD-EVHLLNDTLASEQKKSRELQWALEK 3226
Query: 264 QINDLKSENDALNEKLKS-----EEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNE 318
+ L + E+L+ E QK+R + L Q L + + +++ + +
Sbjct: 3227 EKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDA 3286
Query: 319 KLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQ---LSTEQAVL 375
+L ++ + ++++ L+++ + ++ EL A++ + L +E +
Sbjct: 3287 QLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLK 3346
Query: 376 QESLEKESKVNKRLSMENEELLWKL 400
+ + E K ++ + + NE +KL
Sbjct: 3347 ELQKQLEEKHSRIVELLNETEKYKL 3371
Score = 42.4 bits (98), Expect = 8e-04
Identities = 67/307 (21%), Positives = 132/307 (42%), Gaps = 31/307 (10%)
Query: 98 KFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEA 157
+ EA +++ E+ LK H +SQE + + + + + EK L E
Sbjct: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831
Query: 158 FVQQ--HQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKL 215
QQ E+ E++ F + +E Y E E+Y L+ + D E SK
Sbjct: 832 LKQQCIQLNEEIEKQRNTFSFAEKNFEV---NYQELQEEYACLLKVKDDL-----EDSKN 883
Query: 216 EIEASHSEKLELLKKAYEA-----SLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKS 270
+ E + KL+ L + + ++K E K+ E E +EK +L
Sbjct: 884 KQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELME 943
Query: 271 ENDALN-EKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMK 329
+ + EKL+ ++ E+ K+ +I +L +E++SLK ++ Q ++ +
Sbjct: 944 KLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK-------QEKEQVSLRCRE 996
Query: 330 MEKLVDNNTALVDKLKRFQQENEELKARMDKHMAI-SRQLSTEQAVLQESLEKESK--VN 386
+E ++++N A + Q + ++ + +D + + SR + + +S +ESK V
Sbjct: 997 LEIIINHNRA-----ENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVE 1051
Query: 387 KRLSMEN 393
++S EN
Sbjct: 1052 DKVSFEN 1058
Score = 40.8 bits (94), Expect = 0.002
Identities = 54/272 (19%), Positives = 118/272 (43%), Gaps = 27/272 (9%)
Query: 70 ELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQH---LLSEREEALKQH-KTLSQ 125
EL ++ + ++++ + L LA K L ++ L EE K+ + L
Sbjct: 3188 ELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKF 3247
Query: 126 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTR-EYEKL 184
L + + + + E+ ++ NE Q E+ + A+ +E + R E E EK+
Sbjct: 3248 SLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKV 3307
Query: 185 RDTYIEEAEKYKMQLQEQFDNLNAAHETS------------KLEIEASHSEKLELLKKAY 232
R + + +L Q + + ++ + ++E HS +ELL +
Sbjct: 3308 RIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETE 3367
Query: 233 EASL------SEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKR 286
+ L +++K ++ +K+L+ E +K++++L+S+ + L +L E+KR
Sbjct: 3368 KYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEG-QKKMHELQSKVEDLQRQL---EEKR 3423
Query: 287 RAREKANLKNPQIMYLEQELESLKAVLEIKNE 318
+ K +L+ ++ + QE + + E K E
Sbjct: 3424 QQVYKLDLEGQRLQGIMQEFQKQELEREEKRE 3455
Score = 38.1 bits (87), Expect = 0.016
Identities = 57/246 (23%), Positives = 108/246 (43%), Gaps = 38/246 (15%)
Query: 97 TKFEALTVVIQHLLSEREEALKQH----KTLSQELVNLRGELVTASTTCEKLEKARNELQ 152
TK E L + LS+ E LKQ L++E+ +L+ E S C +LE N +
Sbjct: 948 TKREKLE--LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005
Query: 153 TVYEAFVQQHQAEKTERENRLKEFYTREYE----KLRDTYIEEAEKYKMQLQEQFDNLNA 208
VQ + + + + +R E K+ ++ EE+ K ++ + F+N+
Sbjct: 1006 AEN---VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEES-KIMVEDKVSFENMTV 1061
Query: 209 AHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDL 268
E+ + ++ H L + K + SL + + L+K++N L
Sbjct: 1062 GEESKQEQLILDH--------------LPSVTK-----ESSLRATQPSENDKLQKELNVL 1102
Query: 269 KSENDALNEKLKSEEQKRRAREKANLKNPQIM-YLEQELESLKAVLEIKNEKLHQQDIKL 327
KSE + L +L+ E Q+ + Q+ Y+E E + KA+ +K E + Q+ K+
Sbjct: 1103 KSEQNDL--RLQMEAQRICLSLVYSTHVDQVREYMENEKD--KALCSLKEELIFAQEEKI 1158
Query: 328 MKMEKL 333
+++K+
Sbjct: 1159 KELQKI 1164
Score = 34.7 bits (78), Expect = 0.17
Identities = 57/282 (20%), Positives = 125/282 (44%), Gaps = 35/282 (12%)
Query: 88 LKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNL----------RGELVTA 137
+K +L N K LT + L ERE ++++ +++ + VN+ E+V
Sbjct: 2412 MKNVLKETNFKMNQLTQELFSLKRERE-SVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2470
Query: 138 STTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKM 197
+ LE QT +++F + + E RL + + K D + + K
Sbjct: 2471 EDALKSLEN-----QTYFKSFEENGKGSIINLETRLLQLESTVSAK--DLELTQCYKQIK 2523
Query: 198 QLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEK 257
+QEQ ET L+ + + +K+ + +K A +S+I+ E ++ + +
Sbjct: 2524 DMQEQ-----GQFETEMLQKKIVNLQKI-VEEKVAAALVSQIQL--EAVQEYAKFCQDNQ 2575
Query: 258 QESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKN 317
S E + ++++ N ++L S+ R + Q++ + L K +EI
Sbjct: 2576 TISSEPERTNIQNLNQLREDELGSDISALTLR--ISELESQVVEMHTSLILEKEQVEIAE 2633
Query: 318 EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMD 359
+ + +++ KL++++KL++ N ++ Q+E E+ ++ D
Sbjct: 2634 KNVLEKEKKLLELQKLLEGN-------EKKQREKEKKRSPQD 2668
Score = 34.3 bits (77), Expect = 0.23
Identities = 49/243 (20%), Positives = 112/243 (46%), Gaps = 24/243 (9%)
Query: 118 KQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKT--ERENRLKE 175
++ K LS+EL E++ +++ + ++++ + T+ E + +KT R++ E
Sbjct: 1512 EEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE---EMFSKDKTFIVRQSIHDE 1568
Query: 176 FYTREYEKLRDTYI--EEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYE 233
+ R + E+ E + +L Q+ H+ + + +H ++E ++ E
Sbjct: 1569 ISVSSMDASRQLMLNEEQLEDMRQELVRQYQE----HQQATELLRQAHMRQMERQREDQE 1624
Query: 234 ASLSEIKK-GHEIEKKSL---EDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAR 289
EIK+ ++ ++S E+L+SE++ L +++ LK + A EKL E + +
Sbjct: 1625 QLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ 1684
Query: 290 EKANLKN----PQIMYLEQELESL-----KAVLEIKNEKLHQQDIKLMKMEKLVDNNTAL 340
+ +N + + E+EL+ +L + L + + +L+K+ V TA
Sbjct: 1685 TQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAA 1744
Query: 341 VDK 343
V++
Sbjct: 1745 VEE 1747
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 69.7 bits (169), Expect = 5e-12
Identities = 85/347 (24%), Positives = 158/347 (45%), Gaps = 66/347 (19%)
Query: 61 DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH 120
D EKTL ++ + + ++ I +L+Q L C + + + L Q + ERE +Q
Sbjct: 1925 DGYADEKTL----FERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980
Query: 121 KTLSQELVNLRGELV--TASTTCEKLE------KARNELQTVYEA-----------FVQQ 161
+ + E + +L+ T EKLE K R++LQ +A F++
Sbjct: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040
Query: 162 HQAEKTE-----RENRLKEFYTREYEKL-----------RDTYIEEAEKYKMQLQ--EQF 203
Q + TE ++N+ E + K RD + +E +K + QL+ +F
Sbjct: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
Query: 204 DNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEK 263
++ H+T ++E A+H + E K E LS+ + +I++++ E+ E LE
Sbjct: 2101 QPISE-HQTREVEQLANHLK--EKTDKCSELLLSKEQLQRDIQERN------EEIEKLEF 2151
Query: 264 QINDLKSENDALNEK----------LKSEEQKRRAREKANLKNPQIMYLEQELESLKAVL 313
++ +L+ + K L E Q + R+ + K +I LE++LE + L
Sbjct: 2152 RVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREEL 2211
Query: 314 EIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK 360
E KNE++ Q ++L +K ++ T +L+ +QEN+ K M+K
Sbjct: 2212 ENKNEEVQQLHMQLEIQKK--ESTT----RLQELEQENKLFKDDMEK 2252
Score = 63.5 bits (153), Expect = 4e-10
Identities = 82/370 (22%), Positives = 160/370 (43%), Gaps = 46/370 (12%)
Query: 67 KTLELTQYKTKCENQSGFIL--------QLKQLLACGNTKFEALTVVIQHLLSEREEALK 118
K + K K + + G IL QL+ L+ + E + Q + + + +
Sbjct: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560
Query: 119 QHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYT 178
HK+LS + +L+ E+V+AS + ++LE T Y+ ++ + EK +R+ E
Sbjct: 561 AHKSLST-VEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQE 619
Query: 179 REYEKLRD----TYIEEAEKYKMQLQEQF--------DNLNAAHETS--------KLEIE 218
E E+LR ++ EE K K L+ + DNL ++ +IE
Sbjct: 620 AELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIE 679
Query: 219 ASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEK 278
EK L+ K + L EI K +++ + L++ K E + QIN+L+ E + L ++
Sbjct: 680 TMQFEKDNLITKQNQLIL-EISKLKDLQ----QSLVNSKSEEMTLQINELQKEIEILRQE 734
Query: 279 LKS----EEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKL- 333
K E++ + + K L Q+ E +L+ A LE +N L + L M K+
Sbjct: 735 EKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794
Query: 334 ----VDNNTALVDKLKRFQQEN---EELKARMDKHMAISRQLSTEQAVLQESLEKESKVN 386
+ +D +K +++ +E++ ++++ + +Q +++ S
Sbjct: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854
Query: 387 KRLSMENEEL 396
K + +EL
Sbjct: 855 KNFEVNYQEL 864
Score = 53.1 bits (126), Expect = 5e-07
Identities = 66/327 (20%), Positives = 143/327 (43%), Gaps = 38/327 (11%)
Query: 100 EALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFV 159
+ L + Q L + H + + +L+ + +++T E+ + + Q E F
Sbjct: 236 QKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFT 295
Query: 160 QQ-------------HQAEKTERENRLKEFYTRE--YEKLRDTYIEE------------- 191
Q Q +K E N+ +E +E E+L IEE
Sbjct: 296 MQISFLQEKIKVYEMEQDKKVENSNK-EEIQEKETIIEELNTKIIEEEKKTLELKDKLTT 354
Query: 192 AEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLK--KAYEASLSEIKKGHEIEKKS 249
A+K +LQEQ N + KLE+ S ++ + + K ++ E++K + + +
Sbjct: 355 ADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF 414
Query: 250 LEDLLSEKQESLEKQINDLKSENDAL-NEKLKSEEQKRRAREKANLKNPQIMYLEQELES 308
D++ ++ ++++ L++E D + +++ +Q+ + A ++ + + + E+E+
Sbjct: 415 ETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRH-KGEMEN 473
Query: 309 LKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQL 368
A+ N +++ IKLM + + + N L D + ++ EEL +++ A+ RQL
Sbjct: 474 --ALRSYSNITVNEDQIKLMNVA-INELNIKLQDTNSQKEKLKEELGLILEEKCALQRQL 530
Query: 369 STEQAVLQESLEKESKVNKRLSMENEE 395
E V + S +E R ++ +E
Sbjct: 531 --EDLVEELSFSREQIQRARQTIAEQE 555
Score = 50.1 bits (118), Expect = 4e-06
Identities = 70/297 (23%), Positives = 142/297 (47%), Gaps = 39/297 (13%)
Query: 110 LSEREEALKQHKT--LSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKT 167
+ E E A KQH+ L++EL +R VT T E L++ + +EA ++Q T
Sbjct: 159 MMESELAGKQHEIEELNRELEEMR---VTYGT--EGLQQLQE-----FEAAIKQRDGIIT 208
Query: 168 ERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLEL 227
+ L++ + E +R+ ++E E+ +LQ QF L A+ ET + ++HS
Sbjct: 209 QLTANLQQARREKDETMRE-FLELTEQ-SQKLQIQFQQLQAS-ETLR---NSTHSSTAAD 262
Query: 228 LKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRR 287
L +A + L+ H+ + + + LL + Q+ E D + L EK+K E ++
Sbjct: 263 LLQAKQQILT-----HQQQLEEQDHLLEDYQKKKE----DFTMQISFLQEKIKVYEMEQD 313
Query: 288 AREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKM-EKLVDNNTALVDKLKR 346
+ + + K +E++ + ++E N K+ +++ K +++ +KL + L + ++
Sbjct: 314 KKVENSNK--------EEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQ 365
Query: 347 FQQENEE---LKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKL 400
Q+N+E +K + RQ S E L ++E+ K N + S +++ ++
Sbjct: 366 IVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 422
Score = 44.7 bits (104), Expect = 2e-04
Identities = 65/325 (20%), Positives = 139/325 (42%), Gaps = 28/325 (8%)
Query: 91 LLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNE 150
LL C + + V Q + ++A ++L E+ L ++ T ++ +++
Sbjct: 3052 LLNCLEQRIQEQGVEYQAAMECLQKA--DRRSLLSEIQALHAQMNGRKITLKREQESEKP 3109
Query: 151 LQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAH 210
Q + E +QQ Q++ E + L R E E+ KM + E L +
Sbjct: 3110 SQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ-----EQLSSEKMVVAE----LKSEL 3160
Query: 211 ETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQE-------SLEK 263
+KLE+E + + + LK+ EA E+K + E L D L+ +Q+ +LEK
Sbjct: 3161 AQTKLELETTLKAQHKHLKEL-EAFRLEVKDKTD-EVHLLNDTLASEQKKSRELQWALEK 3218
Query: 264 QINDLKSENDALNEKLKS-----EEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNE 318
+ L + E+L+ E QK+R + L Q L + + +++ + +
Sbjct: 3219 EKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDA 3278
Query: 319 KLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQ---LSTEQAVL 375
+L ++ + ++++ L+++ + ++ EL A++ + L +E +
Sbjct: 3279 QLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLK 3338
Query: 376 QESLEKESKVNKRLSMENEELLWKL 400
+ + E K ++ + + NE +KL
Sbjct: 3339 ELQKQLEEKHSRIVELLNETEKYKL 3363
Score = 42.4 bits (98), Expect = 8e-04
Identities = 67/307 (21%), Positives = 132/307 (42%), Gaps = 31/307 (10%)
Query: 98 KFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEA 157
+ EA +++ E+ LK H +SQE + + + + + EK L E
Sbjct: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831
Query: 158 FVQQ--HQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKL 215
QQ E+ E++ F + +E Y E E+Y L+ + D E SK
Sbjct: 832 LKQQCIQLNEEIEKQRNTFSFAEKNFEV---NYQELQEEYACLLKVKDDL-----EDSKN 883
Query: 216 EIEASHSEKLELLKKAYEA-----SLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKS 270
+ E + KL+ L + + ++K E K+ E E +EK +L
Sbjct: 884 KQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELME 943
Query: 271 ENDALN-EKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMK 329
+ + EKL+ ++ E+ K+ +I +L +E++SLK ++ Q ++ +
Sbjct: 944 KLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK-------QEKEQVSLRCRE 996
Query: 330 MEKLVDNNTALVDKLKRFQQENEELKARMDKHMAI-SRQLSTEQAVLQESLEKESK--VN 386
+E ++++N A + Q + ++ + +D + + SR + + +S +ESK V
Sbjct: 997 LEIIINHNRA-----ENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVE 1051
Query: 387 KRLSMEN 393
++S EN
Sbjct: 1052 DKVSFEN 1058
Score = 40.8 bits (94), Expect = 0.002
Identities = 54/272 (19%), Positives = 118/272 (43%), Gaps = 27/272 (9%)
Query: 70 ELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQH---LLSEREEALKQH-KTLSQ 125
EL ++ + ++++ + L LA K L ++ L EE K+ + L
Sbjct: 3180 ELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKF 3239
Query: 126 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTR-EYEKL 184
L + + + + E+ ++ NE Q E+ + A+ +E + R E E EK+
Sbjct: 3240 SLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKV 3299
Query: 185 RDTYIEEAEKYKMQLQEQFDNLNAAHETS------------KLEIEASHSEKLELLKKAY 232
R + + +L Q + + ++ + ++E HS +ELL +
Sbjct: 3300 RIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETE 3359
Query: 233 EASL------SEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKR 286
+ L +++K ++ +K+L+ E +K++++L+S+ + L +L E+KR
Sbjct: 3360 KYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEG-QKKMHELQSKVEDLQRQL---EEKR 3415
Query: 287 RAREKANLKNPQIMYLEQELESLKAVLEIKNE 318
+ K +L+ ++ + QE + + E K E
Sbjct: 3416 QQVYKLDLEGQRLQGIMQEFQKQELEREEKRE 3447
Score = 38.1 bits (87), Expect = 0.016
Identities = 57/246 (23%), Positives = 108/246 (43%), Gaps = 38/246 (15%)
Query: 97 TKFEALTVVIQHLLSEREEALKQH----KTLSQELVNLRGELVTASTTCEKLEKARNELQ 152
TK E L + LS+ E LKQ L++E+ +L+ E S C +LE N +
Sbjct: 948 TKREKLE--LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005
Query: 153 TVYEAFVQQHQAEKTERENRLKEFYTREYE----KLRDTYIEEAEKYKMQLQEQFDNLNA 208
VQ + + + + +R E K+ ++ EE+ K ++ + F+N+
Sbjct: 1006 AEN---VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEES-KIMVEDKVSFENMTV 1061
Query: 209 AHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDL 268
E+ + ++ H L + K + SL + + L+K++N L
Sbjct: 1062 GEESKQEQLILDH--------------LPSVTK-----ESSLRATQPSENDKLQKELNVL 1102
Query: 269 KSENDALNEKLKSEEQKRRAREKANLKNPQIM-YLEQELESLKAVLEIKNEKLHQQDIKL 327
KSE + L +L+ E Q+ + Q+ Y+E E + KA+ +K E + Q+ K+
Sbjct: 1103 KSEQNDL--RLQMEAQRICLSLVYSTHVDQVREYMENEKD--KALCSLKEELIFAQEEKI 1158
Query: 328 MKMEKL 333
+++K+
Sbjct: 1159 KELQKI 1164
Score = 34.7 bits (78), Expect = 0.17
Identities = 57/282 (20%), Positives = 125/282 (44%), Gaps = 35/282 (12%)
Query: 88 LKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNL----------RGELVTA 137
+K +L N K LT + L ERE ++++ +++ + VN+ E+V
Sbjct: 2404 MKNVLKETNFKMNQLTQELFSLKRERE-SVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2462
Query: 138 STTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKM 197
+ LE QT +++F + + E RL + + K D + + K
Sbjct: 2463 EDALKSLEN-----QTYFKSFEENGKGSIINLETRLLQLESTVSAK--DLELTQCYKQIK 2515
Query: 198 QLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEK 257
+QEQ ET L+ + + +K+ + +K A +S+I+ E ++ + +
Sbjct: 2516 DMQEQ-----GQFETEMLQKKIVNLQKI-VEEKVAAALVSQIQL--EAVQEYAKFCQDNQ 2567
Query: 258 QESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKN 317
S E + ++++ N ++L S+ R + Q++ + L K +EI
Sbjct: 2568 TISSEPERTNIQNLNQLREDELGSDISALTLR--ISELESQVVEMHTSLILEKEQVEIAE 2625
Query: 318 EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMD 359
+ + +++ KL++++KL++ N ++ Q+E E+ ++ D
Sbjct: 2626 KNVLEKEKKLLELQKLLEGN-------EKKQREKEKKRSPQD 2660
Score = 34.3 bits (77), Expect = 0.23
Identities = 49/243 (20%), Positives = 112/243 (46%), Gaps = 24/243 (9%)
Query: 118 KQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKT--ERENRLKE 175
++ K LS+EL E++ +++ + ++++ + T+ E + +KT R++ E
Sbjct: 1512 EEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE---EMFSKDKTFIVRQSIHDE 1568
Query: 176 FYTREYEKLRDTYI--EEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYE 233
+ R + E+ E + +L Q+ H+ + + +H ++E ++ E
Sbjct: 1569 ISVSSMDASRQLMLNEEQLEDMRQELVRQYQE----HQQATELLRQAHMRQMERQREDQE 1624
Query: 234 ASLSEIKK-GHEIEKKSL---EDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAR 289
EIK+ ++ ++S E+L+SE++ L +++ LK + A EKL E + +
Sbjct: 1625 QLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ 1684
Query: 290 EKANLKN----PQIMYLEQELESL-----KAVLEIKNEKLHQQDIKLMKMEKLVDNNTAL 340
+ +N + + E+EL+ +L + L + + +L+K+ V TA
Sbjct: 1685 TQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAA 1744
Query: 341 VDK 343
V++
Sbjct: 1745 VEE 1747
>gi|124249396 coiled-coil domain containing 30 [Homo sapiens]
Length = 783
Score = 69.3 bits (168), Expect = 6e-12
Identities = 92/365 (25%), Positives = 169/365 (46%), Gaps = 68/365 (18%)
Query: 80 NQSGFILQLKQLL-----ACGNTKFEALTVVIQHLLSEREEALKQHKTLSQE-------- 126
NQ G + QL Q L C + + E Q+L LKQH +L QE
Sbjct: 236 NQQGEVQQLHQNLHRLQILCNSAENELRYERGQNL------DLKQHNSLLQEENIKIKIE 289
Query: 127 LVNLRGELVTASTTCEKLEKARNELQTVY---EAFVQQHQAEKTERENRLKEFYTREYEK 183
L + + +L+ ++ C L Q E V +H + + +N L+E +E K
Sbjct: 290 LKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKH-TQSIKSQNNLQEKLVQEKSK 348
Query: 184 LRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK-KG 242
+ D AE+ + LQ + ++ + T + SEK +L +K EA+ +E K K
Sbjct: 349 VAD-----AEEKILDLQRKLEHAHKVCLT-----DTCISEKQQLEEKIKEATQNEAKVKQ 398
Query: 243 HEIEKKSLEDLLSEKQESLEKQINDLKS-----------------ENDALNEKLKSEEQK 285
E++ LL + + L +Q+ L+ + +AL ++L++E++K
Sbjct: 399 QYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRK 458
Query: 286 RRAREKANLK-NPQIMYLEQELESLKA-------VLEIK----NEKLHQQDIKLMKMEKL 333
K+N + + ++ L+QE E+L+ +L + NEK HQQ +KL K++
Sbjct: 459 YDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYR 518
Query: 334 VDNNTALVDK-LKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSME 392
+ N L DK + +F+ E L+ +++K AI Q++ + L L ++ K+ +++ +E
Sbjct: 519 LTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTL---LLEKRKLQEQV-IE 574
Query: 393 NEELL 397
E+L+
Sbjct: 575 QEQLI 579
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.330
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,044,005
Number of Sequences: 37866
Number of extensions: 676698
Number of successful extensions: 10776
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 350
Number of HSP's successfully gapped in prelim test: 1273
Number of HSP's that attempted gapping in prelim test: 4821
Number of HSP's gapped (non-prelim): 4115
length of query: 436
length of database: 18,247,518
effective HSP length: 105
effective length of query: 331
effective length of database: 14,271,588
effective search space: 4723895628
effective search space used: 4723895628
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.