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Search of human proteins with 172073175
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|172073175 microtubule associated serine/threonine
kinase-like [Homo sapiens]
(878 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|172073175 microtubule associated serine/threonine kinase-like... 1769 0.0
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 145 2e-34
gi|6005814 serine/threonine kinase 38 [Homo sapiens] 142 2e-33
gi|148727255 microtubule associated serine/threonine kinase fami... 142 2e-33
gi|112363080 microtubule associated serine/threonine kinase 2 [H... 141 2e-33
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 141 2e-33
gi|24307971 serine/threonine kinase 38 like [Homo sapiens] 140 5e-33
gi|4758666 LATS homolog 1 [Homo sapiens] 138 3e-32
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 137 6e-32
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 137 6e-32
gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo sapiens] 136 1e-31
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 135 2e-31
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 134 3e-31
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 133 6e-31
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 133 6e-31
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 133 6e-31
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 131 3e-30
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 129 9e-30
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 128 2e-29
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 128 2e-29
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 128 3e-29
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 125 2e-28
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 125 2e-28
gi|4885563 protein kinase C, epsilon [Homo sapiens] 124 5e-28
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 122 1e-27
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 122 1e-27
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 122 1e-27
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 122 1e-27
gi|4506067 protein kinase C, alpha [Homo sapiens] 122 2e-27
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 121 2e-27
>gi|172073175 microtubule associated serine/threonine kinase-like
[Homo sapiens]
Length = 878
Score = 1769 bits (4582), Expect = 0.0
Identities = 878/878 (100%), Positives = 878/878 (100%)
Query: 1 MDPTAGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYLGQKGGKLYA 60
MDPTAGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYLGQKGGKLYA
Sbjct: 1 MDPTAGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYLGQKGGKLYA 60
Query: 61 VKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKS 120
VKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKS
Sbjct: 61 VKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKS 120
Query: 121 LLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKV 180
LLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKV
Sbjct: 121 LLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKV 180
Query: 181 TLNRDINMMDILTTPSMAKPRQDYSRTPGQVLSLISSLGFNTPIAEKNQDPANILSACLS 240
TLNRDINMMDILTTPSMAKPRQDYSRTPGQVLSLISSLGFNTPIAEKNQDPANILSACLS
Sbjct: 181 TLNRDINMMDILTTPSMAKPRQDYSRTPGQVLSLISSLGFNTPIAEKNQDPANILSACLS 240
Query: 241 ETSQLSQGLVCPMSVDQKDTTPYSSKLLKSCLETVASNPGMPVKCLTSNLLQSRKRLATS 300
ETSQLSQGLVCPMSVDQKDTTPYSSKLLKSCLETVASNPGMPVKCLTSNLLQSRKRLATS
Sbjct: 241 ETSQLSQGLVCPMSVDQKDTTPYSSKLLKSCLETVASNPGMPVKCLTSNLLQSRKRLATS 300
Query: 301 SASSQSHTFISSVESECHSSPKWEKDCQESDEALGPTMMSWNAVEKLCAKSANAIETKGF 360
SASSQSHTFISSVESECHSSPKWEKDCQESDEALGPTMMSWNAVEKLCAKSANAIETKGF
Sbjct: 301 SASSQSHTFISSVESECHSSPKWEKDCQESDEALGPTMMSWNAVEKLCAKSANAIETKGF 360
Query: 361 NKKDLELALSPIHNSSALPTTGRSCVNLAKKCFSGEVSWEAVELDVNNINMDTDTSQLGF 420
NKKDLELALSPIHNSSALPTTGRSCVNLAKKCFSGEVSWEAVELDVNNINMDTDTSQLGF
Sbjct: 361 NKKDLELALSPIHNSSALPTTGRSCVNLAKKCFSGEVSWEAVELDVNNINMDTDTSQLGF 420
Query: 421 HQSNQWAVDSGGISEEHLGKRSLKRNFELVDSSPCKKIIQNKKTCVEYKHNEMTNCYTNQ 480
HQSNQWAVDSGGISEEHLGKRSLKRNFELVDSSPCKKIIQNKKTCVEYKHNEMTNCYTNQ
Sbjct: 421 HQSNQWAVDSGGISEEHLGKRSLKRNFELVDSSPCKKIIQNKKTCVEYKHNEMTNCYTNQ 480
Query: 481 NTGLTVEVQDLKLSVHKSQQNDCANKENIVNSFTDKQQTPEKLPIPMIAKNLMCELDEDC 540
NTGLTVEVQDLKLSVHKSQQNDCANKENIVNSFTDKQQTPEKLPIPMIAKNLMCELDEDC
Sbjct: 481 NTGLTVEVQDLKLSVHKSQQNDCANKENIVNSFTDKQQTPEKLPIPMIAKNLMCELDEDC 540
Query: 541 EKNSKRDYLSSSFLCSDDDRASKNISMNSDSSFPGISIMESPLESQPLDSDRSIKESSFE 600
EKNSKRDYLSSSFLCSDDDRASKNISMNSDSSFPGISIMESPLESQPLDSDRSIKESSFE
Sbjct: 541 EKNSKRDYLSSSFLCSDDDRASKNISMNSDSSFPGISIMESPLESQPLDSDRSIKESSFE 600
Query: 601 ESNIEDPLIVTPDCQEKTSPKGVENPAVQESNQKMLGPPLEVLKTLASKRNAVAFRSFNS 660
ESNIEDPLIVTPDCQEKTSPKGVENPAVQESNQKMLGPPLEVLKTLASKRNAVAFRSFNS
Sbjct: 601 ESNIEDPLIVTPDCQEKTSPKGVENPAVQESNQKMLGPPLEVLKTLASKRNAVAFRSFNS 660
Query: 661 HINASNNSEPSRMNMTSLDAMDISCAYSGSYPMAITPTQKRRSCMPHQTPNQIKSGTPYR 720
HINASNNSEPSRMNMTSLDAMDISCAYSGSYPMAITPTQKRRSCMPHQTPNQIKSGTPYR
Sbjct: 661 HINASNNSEPSRMNMTSLDAMDISCAYSGSYPMAITPTQKRRSCMPHQTPNQIKSGTPYR 720
Query: 721 TPKSVRRGVAPVDDGRILGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDE 780
TPKSVRRGVAPVDDGRILGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDE
Sbjct: 721 TPKSVRRGVAPVDDGRILGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDE 780
Query: 781 TPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWE 840
TPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWE
Sbjct: 781 TPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWE 840
Query: 841 NLQHQTMPFIPQPDDETDTSYFEARNTAQHLTVSGFSL 878
NLQHQTMPFIPQPDDETDTSYFEARNTAQHLTVSGFSL
Sbjct: 841 NLQHQTMPFIPQPDDETDTSYFEARNTAQHLTVSGFSL 878
>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
sapiens]
Length = 1570
Score = 145 bits (365), Expect = 2e-34
Identities = 73/157 (46%), Positives = 105/157 (66%), Gaps = 2/157 (1%)
Query: 28 KPPSIEEFSIVKPISRGAFGKVYLGQKGG--KLYAVKVVKKADMINKNMTHQVQAERDAL 85
KPP +F +K IS GA+G VYL + + +A+K + K ++I +N Q ERD L
Sbjct: 367 KPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDIL 426
Query: 86 ALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALD 145
+++PF+V ++ S ++ ++ +VMEY+ GGD +LL G EMA Y +E LAL+
Sbjct: 427 TFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALE 486
Query: 146 YLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTL 182
YLH +GI+HRDLKPDN+LI++ GHIKLTDFGLSK+ L
Sbjct: 487 YLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGL 523
Score = 131 bits (329), Expect = 3e-30
Identities = 60/140 (42%), Positives = 86/140 (61%), Gaps = 3/140 (2%)
Query: 734 DGRILGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRD 793
D ++ GTP+Y+APE++L + +G VDWWA+G+ L+EFL G PF +TP+++F ++ D
Sbjct: 544 DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDD 603
Query: 794 IPWPEGEEKLSDNAQSAVEILLTIDDTKR---AGMKELKRHPLFSDVDWENLQHQTMPFI 850
I WPEG+E L AQ + LL + R G E+K+H F D+DW L Q FI
Sbjct: 604 ILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFI 663
Query: 851 PQPDDETDTSYFEARNTAQH 870
P + E DTSYF+ R+ H
Sbjct: 664 PHLESEDDTSYFDTRSDRYH 683
>gi|6005814 serine/threonine kinase 38 [Homo sapiens]
Length = 465
Score = 142 bits (357), Expect = 2e-33
Identities = 70/148 (47%), Positives = 103/148 (69%), Gaps = 2/148 (1%)
Query: 32 IEEFSIVKPISRGAFGKVYLGQKG--GKLYAVKVVKKADMINKNMTHQVQAERDALALSK 89
+E+F +K I RGAFG+V L QK G +YA+K+++KADM+ K ++AERD L +
Sbjct: 86 LEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 145
Query: 90 SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHR 149
S ++V ++YS Q N+YL+ME+L GGD+ +LL EE YI+E LA+D +H+
Sbjct: 146 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 205
Query: 150 HGIIHRDLKPDNMLISNEGHIKLTDFGL 177
G IHRD+KPDN+L+ ++GH+KL+DFGL
Sbjct: 206 LGFIHRDIKPDNLLLDSKGHVKLSDFGL 233
Score = 80.5 bits (197), Expect = 6e-15
Identities = 41/130 (31%), Positives = 72/130 (55%), Gaps = 5/130 (3%)
Query: 738 LGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNIL--KRDIP 795
+GTPDY+APE+ + + DWW+LGV ++E L G PPF ETPQ+ ++ ++ K +
Sbjct: 283 VGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLT 342
Query: 796 WPEGEEKLSDNAQSAVEILLTIDDTK--RAGMKELKRHPLFSDVDWENLQHQTMPFIPQP 853
+P E +S+ A+ + + + G++E+K + F VDWE+++ + +
Sbjct: 343 FPP-EVPISEKAKDLILRFCCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEI 401
Query: 854 DDETDTSYFE 863
DTS F+
Sbjct: 402 KSIDDTSNFD 411
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 142 bits (357), Expect = 2e-33
Identities = 71/180 (39%), Positives = 112/180 (62%), Gaps = 2/180 (1%)
Query: 5 AGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYL--GQKGGKLYAVK 62
+G+ + P + + + + P +F +K IS GA+G VY ++ + +A+K
Sbjct: 351 SGTAETPETDESVSSSNASLKLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMK 410
Query: 63 VVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLL 122
+ K ++I +N Q ERD L +++PF+V +Y S ++ ++ +VMEY+ GGD +L+
Sbjct: 411 KINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLM 470
Query: 123 HIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTL 182
G +MA Y +E LAL+YLH +GI+HRDLKPDN+L+++ GHIKLTDFGLSKV L
Sbjct: 471 KNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGL 530
Score = 127 bits (319), Expect = 5e-29
Identities = 57/140 (40%), Positives = 88/140 (62%), Gaps = 3/140 (2%)
Query: 734 DGRILGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRD 793
D ++ GTP+Y+APE++L + +G VDWWA+G+ L+EFL G PF +TP+++F ++ +
Sbjct: 551 DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE 610
Query: 794 IPWPEGEEKLSDNAQSAVEILLTIDDTKR---AGMKELKRHPLFSDVDWENLQHQTMPFI 850
I WPE +E +AQ + +LL + +R G E+K+H F +DW +L Q FI
Sbjct: 611 INWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQKAEFI 670
Query: 851 PQPDDETDTSYFEARNTAQH 870
PQ + E DTSYF+ R+ H
Sbjct: 671 PQLESEDDTSYFDTRSEKYH 690
>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
sapiens]
Length = 1798
Score = 141 bits (356), Expect = 2e-33
Identities = 71/157 (45%), Positives = 104/157 (66%), Gaps = 2/157 (1%)
Query: 28 KPPSIEEFSIVKPISRGAFGKVYLGQKGG--KLYAVKVVKKADMINKNMTHQVQAERDAL 85
K PS E+F +K IS GA+G V+L + + +A+K + K ++I +N Q ERD L
Sbjct: 505 KTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDIL 564
Query: 86 ALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALD 145
+++PF+V ++ S + ++ +VMEY+ GGD +LL G +M Y +E LAL+
Sbjct: 565 TFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALE 624
Query: 146 YLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTL 182
YLH +GI+HRDLKPDN+LI++ GHIKLTDFGLSK+ L
Sbjct: 625 YLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGL 661
Score = 132 bits (333), Expect = 1e-30
Identities = 60/140 (42%), Positives = 89/140 (63%), Gaps = 3/140 (2%)
Query: 734 DGRILGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRD 793
D ++ GTP+Y+APE++L + +G VDWWA+G+ L+EFL G PF +TP+++F ++ +
Sbjct: 682 DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE 741
Query: 794 IPWPEGEEKLSDNAQSAVEILLTIDDTKRAG---MKELKRHPLFSDVDWENLQHQTMPFI 850
I WPEG+E L +AQ LL + +R G E+K+HP F+ +DW L Q FI
Sbjct: 742 IVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFI 801
Query: 851 PQPDDETDTSYFEARNTAQH 870
PQ + E DTSYF+ R+ H
Sbjct: 802 PQLESEDDTSYFDTRSERYH 821
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 141 bits (356), Expect = 2e-33
Identities = 71/157 (45%), Positives = 105/157 (66%), Gaps = 2/157 (1%)
Query: 28 KPPSIEEFSIVKPISRGAFGKVYLGQKGG--KLYAVKVVKKADMINKNMTHQVQAERDAL 85
+ P +F +K IS GA+G VYL + + +A+K + K ++I +N QV ERD L
Sbjct: 360 RKPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDIL 419
Query: 86 ALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALD 145
+++PF+V ++ S ++ ++ +VMEY+ GGD +LL G +MA Y +E LAL+
Sbjct: 420 TFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALE 479
Query: 146 YLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTL 182
YLH +GI+HRDLKPDN+LI++ GHIKLTDFGLSK+ L
Sbjct: 480 YLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGL 516
Score = 126 bits (316), Expect = 1e-28
Identities = 57/136 (41%), Positives = 85/136 (62%), Gaps = 3/136 (2%)
Query: 734 DGRILGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRD 793
D ++ GTP+Y+APE++ + +G VDWWA+GV L+EFL G PF +TP+++F ++ +
Sbjct: 537 DKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDE 596
Query: 794 IPWPEGEEKLSDNAQSAVEILL---TIDDTKRAGMKELKRHPLFSDVDWENLQHQTMPFI 850
I WPEG+E L +AQ + LL +D G E+K+HP F +DW L F+
Sbjct: 597 IMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFV 656
Query: 851 PQPDDETDTSYFEARN 866
PQ + E DTSYF+ R+
Sbjct: 657 PQLEAEDDTSYFDTRS 672
>gi|24307971 serine/threonine kinase 38 like [Homo sapiens]
Length = 464
Score = 140 bits (353), Expect = 5e-33
Identities = 68/148 (45%), Positives = 101/148 (68%), Gaps = 2/148 (1%)
Query: 32 IEEFSIVKPISRGAFGKVYLGQKG--GKLYAVKVVKKADMINKNMTHQVQAERDALALSK 89
+++F +K I RGAFG+V L QK G +YA+K+++K+DM+ K ++AERD L +
Sbjct: 87 LDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEAD 146
Query: 90 SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHR 149
++V ++YS Q N+YL+ME+L GGD+ +LL EE YISE LA+D +H+
Sbjct: 147 GAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQ 206
Query: 150 HGIIHRDLKPDNMLISNEGHIKLTDFGL 177
G IHRD+KPDN+L+ +GH+KL+DFGL
Sbjct: 207 LGFIHRDIKPDNLLLDAKGHVKLSDFGL 234
Score = 91.3 bits (225), Expect = 4e-18
Identities = 46/131 (35%), Positives = 76/131 (58%), Gaps = 7/131 (5%)
Query: 738 LGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNIL--KRDIP 795
+GTPDY+APE+ + + DWW+LGV ++E L G PPF ETPQ+ ++ ++ K +
Sbjct: 284 VGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLV 343
Query: 796 WPEGEEKLSDNAQSAVEILLTIDDTKR---AGMKELKRHPLFSDVDWENLQHQTMPFIPQ 852
+P E +S+ A+ + + ID R +G++E+K HP F VDWE+++ + +
Sbjct: 344 FPP-EVPISEKAKDLI-LRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIE 401
Query: 853 PDDETDTSYFE 863
DTS F+
Sbjct: 402 IKSIDDTSNFD 412
>gi|4758666 LATS homolog 1 [Homo sapiens]
Length = 1130
Score = 138 bits (347), Expect = 3e-32
Identities = 70/145 (48%), Positives = 99/145 (68%), Gaps = 2/145 (1%)
Query: 35 FSIVKPISRGAFGKVYLGQKGGK--LYAVKVVKKADMINKNMTHQVQAERDALALSKSPF 92
F +K + GAFG+V L +K LYA K ++K D++ +N V+AERD LA + + +
Sbjct: 705 FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW 764
Query: 93 IVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGI 152
+V LYYS Q +N+Y VM+Y+ GGD+ SLL G F E +A YI+E+ A++ +H+ G
Sbjct: 765 VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGF 824
Query: 153 IHRDLKPDNMLISNEGHIKLTDFGL 177
IHRD+KPDN+LI +GHIKLTDFGL
Sbjct: 825 IHRDIKPDNILIDRDGHIKLTDFGL 849
Score = 80.9 bits (198), Expect = 5e-15
Identities = 47/132 (35%), Positives = 73/132 (55%), Gaps = 6/132 (4%)
Query: 737 ILGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNIL--KRDI 794
++GTP+Y+APE+LL + DWW++GV LFE L G PPF +TP + ++ + +
Sbjct: 910 LVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSL 969
Query: 795 PWPEGEEKLSDNAQSAVEILL--TIDDTKRAGMKELKRHPLFSDVDW-ENLQHQTMPFIP 851
P + KLS A + L D + G E+K HP F +D+ +L+ Q+ +IP
Sbjct: 970 HIPP-QAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIP 1028
Query: 852 QPDDETDTSYFE 863
+ TDTS F+
Sbjct: 1029 KITHPTDTSNFD 1040
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 137 bits (344), Expect = 6e-32
Identities = 71/157 (45%), Positives = 107/157 (68%), Gaps = 6/157 (3%)
Query: 34 EFSIVKPISRGAFGKVYL-----GQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALS 88
+F ++K + +G++GKV+L G G+LYA+KV+KKA + ++ + ERD LA
Sbjct: 66 QFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRS-KMERDILAEV 124
Query: 89 KSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLH 148
PFIV L+Y+ Q+ +YL++++L GGD+ + L F EE Y++E+ALALD+LH
Sbjct: 125 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 184
Query: 149 RHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRD 185
GII+RDLKP+N+L+ EGHIK+TDFGLSK ++ D
Sbjct: 185 SLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHD 221
Score = 85.5 bits (210), Expect = 2e-16
Identities = 51/143 (35%), Positives = 74/143 (51%), Gaps = 10/143 (6%)
Query: 739 GTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPE 798
GT +Y+APE++ R H + DWW+ GV +FE LTG PF + ++ ILK + P
Sbjct: 229 GTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMP- 287
Query: 799 GEEKLSDNAQSAVEILLTIDDTKRA-----GMKELKRHPLFSDVDWENLQHQTM--PFIP 851
+ LS AQS + L + R G++E+KRHP F +DW L + + PF P
Sbjct: 288 --QFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKP 345
Query: 852 QPDDETDTSYFEARNTAQHLTVS 874
DT +F+ TA+ T S
Sbjct: 346 AVGRPEDTFHFDPEFTARTPTDS 368
Score = 68.2 bits (165), Expect = 3e-11
Identities = 65/222 (29%), Positives = 98/222 (44%), Gaps = 21/222 (9%)
Query: 59 YAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDV 118
YAVK++ K+ ++ + +++ L + P I+ L VYLVME + GG++
Sbjct: 449 YAVKIIDKS---KRDPSEEIEI---LLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGEL 502
Query: 119 KSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEG----HIKLTD 174
+ YF E A + + +DYLH G++HRDLKP N+L +E I++ D
Sbjct: 503 LDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCD 562
Query: 175 FGLSKVTLNRDINMMDILTTPSMAKP----RQDYSRTP---GQVLSLISSLGFNTPIAEK 227
FG +K + +M T + P RQ Y + L + L TP A
Sbjct: 563 FGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANG 622
Query: 228 NQD-PANILSACLSETSQLSQGLVCPMSVDQKDTTPYSSKLL 268
D P IL+ S LS G +S KD SK+L
Sbjct: 623 PDDTPEEILARIGSGKYALSGGNWDSISDAAKDVV---SKML 661
Score = 53.1 bits (126), Expect = 1e-06
Identities = 29/97 (29%), Positives = 51/97 (52%), Gaps = 4/97 (4%)
Query: 740 TPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPF---NDETPQQVFQNILKRDIPW 796
T +++APE+L + + A D W+LG+ L+ L G PF D+TP+++ I
Sbjct: 582 TANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYAL 641
Query: 797 PEGE-EKLSDNAQSAVEILLTIDDTKRAGMKELKRHP 832
G + +SD A+ V +L +D +R ++ +HP
Sbjct: 642 SGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHP 678
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 137 bits (344), Expect = 6e-32
Identities = 71/157 (45%), Positives = 107/157 (68%), Gaps = 6/157 (3%)
Query: 34 EFSIVKPISRGAFGKVYL-----GQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALS 88
+F ++K + +G++GKV+L G G+LYA+KV+KKA + ++ + ERD LA
Sbjct: 58 QFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRS-KMERDILAEV 116
Query: 89 KSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLH 148
PFIV L+Y+ Q+ +YL++++L GGD+ + L F EE Y++E+ALALD+LH
Sbjct: 117 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 176
Query: 149 RHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRD 185
GII+RDLKP+N+L+ EGHIK+TDFGLSK ++ D
Sbjct: 177 SLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHD 213
Score = 85.5 bits (210), Expect = 2e-16
Identities = 51/143 (35%), Positives = 74/143 (51%), Gaps = 10/143 (6%)
Query: 739 GTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPE 798
GT +Y+APE++ R H + DWW+ GV +FE LTG PF + ++ ILK + P
Sbjct: 221 GTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMP- 279
Query: 799 GEEKLSDNAQSAVEILLTIDDTKRA-----GMKELKRHPLFSDVDWENLQHQTM--PFIP 851
+ LS AQS + L + R G++E+KRHP F +DW L + + PF P
Sbjct: 280 --QFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKP 337
Query: 852 QPDDETDTSYFEARNTAQHLTVS 874
DT +F+ TA+ T S
Sbjct: 338 AVGRPEDTFHFDPEFTARTPTDS 360
Score = 68.2 bits (165), Expect = 3e-11
Identities = 65/222 (29%), Positives = 98/222 (44%), Gaps = 21/222 (9%)
Query: 59 YAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDV 118
YAVK++ K+ ++ + +++ L + P I+ L VYLVME + GG++
Sbjct: 441 YAVKIIDKS---KRDPSEEIEI---LLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGEL 494
Query: 119 KSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEG----HIKLTD 174
+ YF E A + + +DYLH G++HRDLKP N+L +E I++ D
Sbjct: 495 LDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCD 554
Query: 175 FGLSKVTLNRDINMMDILTTPSMAKP----RQDYSRTP---GQVLSLISSLGFNTPIAEK 227
FG +K + +M T + P RQ Y + L + L TP A
Sbjct: 555 FGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANG 614
Query: 228 NQD-PANILSACLSETSQLSQGLVCPMSVDQKDTTPYSSKLL 268
D P IL+ S LS G +S KD SK+L
Sbjct: 615 PDDTPEEILARIGSGKYALSGGNWDSISDAAKDVV---SKML 653
Score = 53.1 bits (126), Expect = 1e-06
Identities = 29/97 (29%), Positives = 51/97 (52%), Gaps = 4/97 (4%)
Query: 740 TPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPF---NDETPQQVFQNILKRDIPW 796
T +++APE+L + + A D W+LG+ L+ L G PF D+TP+++ I
Sbjct: 574 TANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYAL 633
Query: 797 PEGE-EKLSDNAQSAVEILLTIDDTKRAGMKELKRHP 832
G + +SD A+ V +L +D +R ++ +HP
Sbjct: 634 SGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHP 670
>gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo sapiens]
Length = 1088
Score = 136 bits (342), Expect = 1e-31
Identities = 70/145 (48%), Positives = 100/145 (68%), Gaps = 2/145 (1%)
Query: 35 FSIVKPISRGAFGKVYLGQKGGK--LYAVKVVKKADMINKNMTHQVQAERDALALSKSPF 92
F +K + GAFG+V L K LYA+K ++K D++N+N V+AERD LA + + +
Sbjct: 668 FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEW 727
Query: 93 IVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGI 152
+V LYYS Q +++Y VM+Y+ GGD+ SLL F E +A YI+E+ LA++ +H+ G
Sbjct: 728 VVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGF 787
Query: 153 IHRDLKPDNMLISNEGHIKLTDFGL 177
IHRD+KPDN+LI +GHIKLTDFGL
Sbjct: 788 IHRDIKPDNILIDLDGHIKLTDFGL 812
Score = 84.0 bits (206), Expect = 6e-16
Identities = 48/134 (35%), Positives = 74/134 (55%), Gaps = 10/134 (7%)
Query: 737 ILGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRD--- 793
++GTP+Y+APE+LL + + DWW++GV LFE L G PPF TP + ++ +
Sbjct: 873 LVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTL 932
Query: 794 -IPWPEGEEKLSDNAQSAVEILLTIDDTK--RAGMKELKRHPLFSDVDW-ENLQHQTMPF 849
IP + KLS A+ + L D + R G +LK HP FS +D+ +++ Q P+
Sbjct: 933 HIP---AQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPY 989
Query: 850 IPQPDDETDTSYFE 863
+P DTS F+
Sbjct: 990 VPTISHPMDTSNFD 1003
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 135 bits (339), Expect = 2e-31
Identities = 70/157 (44%), Positives = 109/157 (69%), Gaps = 6/157 (3%)
Query: 34 EFSIVKPISRGAFGKVYL-----GQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALS 88
+F ++K + +G+FGKV+L G G+LYA+KV+KKA + ++ + + ERD L
Sbjct: 72 QFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRV-RTKMERDILVEV 130
Query: 89 KSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLH 148
PFIV L+Y+ Q+ +YL++++L GGDV + L F EE Y++E+ALALD+LH
Sbjct: 131 NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 190
Query: 149 RHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRD 185
+ GI++RDLKP+N+L+ GHIKLTDFGLSK +++++
Sbjct: 191 QLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQE 227
Score = 85.9 bits (211), Expect = 2e-16
Identities = 48/136 (35%), Positives = 73/136 (53%), Gaps = 8/136 (5%)
Query: 739 GTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPE 798
GT +Y+APE++ R H + DWW+ GV +FE LTG PF + + ILK + P
Sbjct: 235 GTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMP- 293
Query: 799 GEEKLSDNAQSAVEILLTIDDTKR---AGMKELKRHPLFSDVDWENLQHQTM--PFIPQP 853
+ LS AQS + +L + R G++E+KRH F+++DW+ L + + PF P
Sbjct: 294 --QFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPAS 351
Query: 854 DDETDTSYFEARNTAQ 869
DT F+ TA+
Sbjct: 352 GKPDDTFCFDPEFTAK 367
Score = 58.2 bits (139), Expect = 3e-08
Identities = 35/125 (28%), Positives = 64/125 (51%), Gaps = 10/125 (8%)
Query: 59 YAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDV 118
+AVK++ K+ ++ + +++ + + P I+ L VYLV + + GG++
Sbjct: 452 FAVKIIDKS---KRDPSEEIEI---LMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGEL 505
Query: 119 KSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEG----HIKLTD 174
+ F E A + ++ +DYLH G++HRDLKP N+L +E I++ D
Sbjct: 506 LDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICD 565
Query: 175 FGLSK 179
FG +K
Sbjct: 566 FGFAK 570
Score = 47.8 bits (112), Expect = 5e-05
Identities = 26/96 (27%), Positives = 51/96 (53%), Gaps = 4/96 (4%)
Query: 740 TPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPF---NDETPQQVFQNILKRDIPW 796
T +++APE+L+ + + A D W+LGV + L G PF ++TP+++ I
Sbjct: 585 TANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSL 644
Query: 797 PEGE-EKLSDNAQSAVEILLTIDDTKRAGMKELKRH 831
G + +SD A+ + +L +D +R +++ +H
Sbjct: 645 SGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKH 680
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 134 bits (338), Expect = 3e-31
Identities = 71/173 (41%), Positives = 115/173 (66%), Gaps = 8/173 (4%)
Query: 17 TEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVY-----LGQKGGKLYAVKVVKKADMI- 70
+E VNR P+ E F +++ + +G +GKV+ G GK++A+KV+KKA ++
Sbjct: 75 SETSVNR--GPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVR 132
Query: 71 NKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDE 130
N T +AER+ L K PFIV L Y+ Q+ +YL++EYL GG++ L G F E
Sbjct: 133 NAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFME 192
Query: 131 EMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLN 183
+ A Y++E+++AL +LH+ GII+RDLKP+N++++++GH+KLTDFGL K +++
Sbjct: 193 DTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIH 245
Score = 85.9 bits (211), Expect = 2e-16
Identities = 48/138 (34%), Positives = 73/138 (52%), Gaps = 10/138 (7%)
Query: 739 GTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPE 798
GT +Y+APE+L+ H AVDWW+LG +++ LTG PPF E ++ ILK + P
Sbjct: 255 GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLP- 313
Query: 799 GEEKLSDNAQSAVEILLTIDDTKRAG-----MKELKRHPLFSDVDWENLQHQTM--PFIP 851
L+ A+ ++ LL + R G E++ HP F ++WE L + + PF P
Sbjct: 314 --PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 371
Query: 852 QPDDETDTSYFEARNTAQ 869
E D S F+++ T Q
Sbjct: 372 LLQSEEDVSQFDSKFTRQ 389
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 133 bits (335), Expect = 6e-31
Identities = 75/190 (39%), Positives = 117/190 (61%), Gaps = 8/190 (4%)
Query: 3 PTAGSKKEPGGGAATEEGVNRI--AVPKPPSIEEFSIVKPISRGAFGKVYLGQK-----G 55
P +G +++ G E + A + F ++K + +G+FGKV+L +K
Sbjct: 37 PGSGPQRDSDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDS 96
Query: 56 GKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIG 115
G LYA+KV+KKA + ++ + + ERD LA PF+V L+Y+ Q+ +YL++++L G
Sbjct: 97 GHLYAMKVLKKATLKVRDRV-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRG 155
Query: 116 GDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDF 175
GD+ + L F EE Y++E+AL LD+LH GII+RDLKP+N+L+ EGHIKLTDF
Sbjct: 156 GDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDF 215
Query: 176 GLSKVTLNRD 185
GLSK ++ +
Sbjct: 216 GLSKEAIDHE 225
Score = 82.8 bits (203), Expect = 1e-15
Identities = 47/138 (34%), Positives = 71/138 (51%), Gaps = 10/138 (7%)
Query: 739 GTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPE 798
GT +Y+APE++ + H + DWW+ GV +FE LTG PF + ++ ILK + P
Sbjct: 233 GTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP- 291
Query: 799 GEEKLSDNAQSAVEILLTIDDTKRA-----GMKELKRHPLFSDVDWENLQHQTM--PFIP 851
+ LS AQS + L + R G +E+KRH +S +DW L + + PF P
Sbjct: 292 --QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKP 349
Query: 852 QPDDETDTSYFEARNTAQ 869
DT YF+ T++
Sbjct: 350 AVAQPDDTFYFDTEFTSR 367
Score = 63.5 bits (153), Expect = 8e-10
Identities = 59/213 (27%), Positives = 94/213 (44%), Gaps = 18/213 (8%)
Query: 59 YAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDV 118
YAVKV+ K+ ++ + +++ L + P I+ L +VYLV E + GG++
Sbjct: 453 YAVKVIDKS---KRDPSEEIEI---LLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGEL 506
Query: 119 KSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGH----IKLTD 174
+ +F E A + + ++YLH G++HRDLKP N+L +E +++ D
Sbjct: 507 LDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICD 566
Query: 175 FGLSKVTLNRDINMMDILTTPSMAKP----RQDYSR---TPGQVLSLISSLGFNTPIAEK 227
FG +K + +M T + P RQ Y + L + L TP A
Sbjct: 567 FGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANG 626
Query: 228 NQD-PANILSACLSETSQLSQGLVCPMSVDQKD 259
D P IL+ S LS G +S KD
Sbjct: 627 PSDTPEEILTRIGSGKFTLSGGNWNTVSETAKD 659
Score = 51.2 bits (121), Expect = 4e-06
Identities = 31/118 (26%), Positives = 57/118 (48%), Gaps = 7/118 (5%)
Query: 740 TPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFND---ETPQQVFQNILKRDIPW 796
T +++APE+L + + D W+LG+ L+ L G PF + +TP+++ I
Sbjct: 586 TANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTL 645
Query: 797 PEGE-EKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVD---WENLQHQTMPFI 850
G +S+ A+ V +L +D +R K++ +HP + D L HQ + +
Sbjct: 646 SGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLV 703
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 133 bits (335), Expect = 6e-31
Identities = 80/200 (40%), Positives = 122/200 (61%), Gaps = 16/200 (8%)
Query: 1 MDPTAG--SKKEPGGGAATEEGVNRI--------AVPKPPSIEEFSIVKPISRGAFGKVY 50
+DP G S +E G + +EGV + A + F ++K + +G+FGKV+
Sbjct: 18 LDPENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVF 77
Query: 51 LGQK-----GGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANN 105
L +K G LYA+KV+KKA + ++ + + ERD LA PF+V L+Y+ Q+
Sbjct: 78 LVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RTKMERDILADVNHPFVVKLHYAFQTEGK 136
Query: 106 VYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLIS 165
+YL++++L GGD+ + L F EE Y++E+AL LD+LH GII+RDLKP+N+L+
Sbjct: 137 LYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLD 196
Query: 166 NEGHIKLTDFGLSKVTLNRD 185
EGHIKLTDFGLSK ++ +
Sbjct: 197 EEGHIKLTDFGLSKEAIDHE 216
Score = 82.8 bits (203), Expect = 1e-15
Identities = 47/138 (34%), Positives = 71/138 (51%), Gaps = 10/138 (7%)
Query: 739 GTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPE 798
GT +Y+APE++ + H + DWW+ GV +FE LTG PF + ++ ILK + P
Sbjct: 224 GTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP- 282
Query: 799 GEEKLSDNAQSAVEILLTIDDTKRA-----GMKELKRHPLFSDVDWENLQHQTM--PFIP 851
+ LS AQS + L + R G +E+KRH +S +DW L + + PF P
Sbjct: 283 --QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKP 340
Query: 852 QPDDETDTSYFEARNTAQ 869
DT YF+ T++
Sbjct: 341 AVAQPDDTFYFDTEFTSR 358
Score = 63.5 bits (153), Expect = 8e-10
Identities = 59/213 (27%), Positives = 94/213 (44%), Gaps = 18/213 (8%)
Query: 59 YAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDV 118
YAVKV+ K+ ++ + +++ L + P I+ L +VYLV E + GG++
Sbjct: 444 YAVKVIDKS---KRDPSEEIEI---LLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGEL 497
Query: 119 KSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGH----IKLTD 174
+ +F E A + + ++YLH G++HRDLKP N+L +E +++ D
Sbjct: 498 LDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICD 557
Query: 175 FGLSKVTLNRDINMMDILTTPSMAKP----RQDYSR---TPGQVLSLISSLGFNTPIAEK 227
FG +K + +M T + P RQ Y + L + L TP A
Sbjct: 558 FGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANG 617
Query: 228 NQD-PANILSACLSETSQLSQGLVCPMSVDQKD 259
D P IL+ S LS G +S KD
Sbjct: 618 PSDTPEEILTRIGSGKFTLSGGNWNTVSETAKD 650
Score = 51.2 bits (121), Expect = 4e-06
Identities = 31/118 (26%), Positives = 57/118 (48%), Gaps = 7/118 (5%)
Query: 740 TPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFND---ETPQQVFQNILKRDIPW 796
T +++APE+L + + D W+LG+ L+ L G PF + +TP+++ I
Sbjct: 577 TANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTL 636
Query: 797 PEGE-EKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVD---WENLQHQTMPFI 850
G +S+ A+ V +L +D +R K++ +HP + D L HQ + +
Sbjct: 637 SGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLV 694
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 133 bits (335), Expect = 6e-31
Identities = 70/157 (44%), Positives = 107/157 (68%), Gaps = 6/157 (3%)
Query: 34 EFSIVKPISRGAFGKVYL-----GQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALS 88
+F ++K + +G+FGKV+L G +LYA+KV+KKA + ++ + + ERD L
Sbjct: 67 QFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRV-RTKMERDILVEV 125
Query: 89 KSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLH 148
PFIV L+Y+ Q+ +YL++++L GGD+ + L F EE Y++E+ALALD+LH
Sbjct: 126 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 185
Query: 149 RHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRD 185
GII+RDLKP+N+L+ EGHIKLTDFGLSK +++ +
Sbjct: 186 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHE 222
Score = 89.0 bits (219), Expect = 2e-17
Identities = 50/138 (36%), Positives = 73/138 (52%), Gaps = 10/138 (7%)
Query: 739 GTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPE 798
GT +Y+APE++ R H + DWW+ GV +FE LTG PF + ++ ILK + P
Sbjct: 230 GTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP- 288
Query: 799 GEEKLSDNAQSAVEILLTIDDTKRA-----GMKELKRHPLFSDVDWENLQHQTM--PFIP 851
+ LS AQS + +L + R G++E+KRH FS +DW L + + PF P
Sbjct: 289 --QFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKP 346
Query: 852 QPDDETDTSYFEARNTAQ 869
DT YF+ TA+
Sbjct: 347 ATGRPEDTFYFDPEFTAK 364
Score = 62.4 bits (150), Expect = 2e-09
Identities = 58/213 (27%), Positives = 93/213 (43%), Gaps = 18/213 (8%)
Query: 59 YAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDV 118
+AVK++ K+ ++ T +++ L + P I+ L VY+V E + GG++
Sbjct: 448 FAVKIIDKS---KRDPTEEIEI---LLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGEL 501
Query: 119 KSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEG----HIKLTD 174
+ +F E A + + ++YLH G++HRDLKP N+L +E I++ D
Sbjct: 502 LDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICD 561
Query: 175 FGLSKVTLNRDINMMDILTTPSMAKP----RQDYSRTP---GQVLSLISSLGFNTPIAEK 227
FG +K + +M T + P RQ Y + L + L TP A
Sbjct: 562 FGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANG 621
Query: 228 NQD-PANILSACLSETSQLSQGLVCPMSVDQKD 259
D P IL+ S LS G +S KD
Sbjct: 622 PDDTPEEILARIGSGKFSLSGGYWNSVSDTAKD 654
Score = 55.1 bits (131), Expect = 3e-07
Identities = 35/107 (32%), Positives = 54/107 (50%), Gaps = 6/107 (5%)
Query: 740 TPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPF---NDETPQQVFQNILKRDIPW 796
T +++APE+L + + A D W+LGV L+ LTG PF D+TP+++ I
Sbjct: 581 TANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSL 640
Query: 797 PEGE-EKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWENL 842
G +SD A+ V +L +D +R + RHP V W+ L
Sbjct: 641 SGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI--VHWDQL 685
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 131 bits (329), Expect = 3e-30
Identities = 67/155 (43%), Positives = 105/155 (67%), Gaps = 6/155 (3%)
Query: 35 FSIVKPISRGAFGKVYL-----GQKGGKLYAVKVVKKADMI-NKNMTHQVQAERDALALS 88
F +++ + +G +GKV+ G GK+YA+KV++KA ++ N T +AER+ L
Sbjct: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126
Query: 89 KSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLH 148
K PFIV L Y+ Q+ +YL++E L GG++ + L G F E+ A Y++E+ LAL +LH
Sbjct: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH 186
Query: 149 RHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLN 183
GII+RDLKP+N+++S++GHIKLTDFGL K +++
Sbjct: 187 SQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIH 221
Score = 83.6 bits (205), Expect = 7e-16
Identities = 46/138 (33%), Positives = 75/138 (54%), Gaps = 10/138 (7%)
Query: 739 GTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPE 798
GT +Y+APE+L+ H AVDWW+LG +++ LTG PPF E ++ I++ + P
Sbjct: 231 GTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALP- 289
Query: 799 GEEKLSDNAQSAVEILLTIDDTKRAG-----MKELKRHPLFSDVDWENLQHQTM--PFIP 851
L+ +A+ V+ L + ++R G +++RHP F ++W++L + PF P
Sbjct: 290 --PYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRP 347
Query: 852 QPDDETDTSYFEARNTAQ 869
E D S F+ R T Q
Sbjct: 348 CLQSEEDVSQFDTRFTRQ 365
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 129 bits (325), Expect = 9e-30
Identities = 66/146 (45%), Positives = 98/146 (67%), Gaps = 3/146 (2%)
Query: 33 EEFSIVKPISRGAFGKVYL--GQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 90
E++ +VK I RGAFG+V L + K+YA+K++ K +MI ++ + ERD +A + S
Sbjct: 90 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 149
Query: 91 PFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRH 150
P++V L+Y+ Q +Y+VMEY+ GGD+ +L+ Y E+ A Y +EV LALD +H
Sbjct: 150 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWAKFYTAEVVLALDAIHSM 208
Query: 151 GIIHRDLKPDNMLISNEGHIKLTDFG 176
G+IHRD+KPDNML+ GH+KL DFG
Sbjct: 209 GLIHRDVKPDNMLLDKHGHLKLADFG 234
Score = 77.4 bits (189), Expect = 5e-14
Identities = 42/136 (30%), Positives = 78/136 (57%), Gaps = 11/136 (8%)
Query: 738 LGTPDYLAPELLLGRA----HGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNIL--K 791
+GTPDY++PE+L + +G DWW++GV L+E L G PF ++ + I+ K
Sbjct: 251 VGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHK 310
Query: 792 RDIPWPEGEEKLSDNAQSAVEILLTIDDTK--RAGMKELKRHPLFSDVD--WENLQHQTM 847
+ +PE E +S +A++ + LT + + R G++E+++HP F + W+N++
Sbjct: 311 NSLCFPEDAE-ISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAA 369
Query: 848 PFIPQPDDETDTSYFE 863
P +P+ + D+S F+
Sbjct: 370 PVVPELSSDIDSSNFD 385
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 128 bits (322), Expect = 2e-29
Identities = 68/162 (41%), Positives = 108/162 (66%), Gaps = 7/162 (4%)
Query: 31 SIEEFSIVKPISRGAFGKVYL-----GQKGGKLYAVKVVKKADMINKNMTHQ-VQAERDA 84
S+E F ++K + GA+GKV+L G GKLYA+KV++KA ++ + T + + ER
Sbjct: 29 SVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSV 88
Query: 85 LALSK-SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALA 143
L L + +PF+V L+Y+ Q+ ++L+++Y+ GG++ + L+ YF E Y E+ LA
Sbjct: 89 LELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLA 148
Query: 144 LDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRD 185
L++LH+ GII+RDLK +N+L+ +EGHI LTDFGLSK L +
Sbjct: 149 LEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEE 190
Score = 84.7 bits (208), Expect = 3e-16
Identities = 53/136 (38%), Positives = 73/136 (53%), Gaps = 15/136 (11%)
Query: 739 GTPDYLAPELLLGRA-HGPAVDWWALGVCLFEFLTGIPPFNDE----TPQQVFQNILKRD 793
GT +Y+APE++ + HG AVDWW+LG+ LFE LTG PF E T +V + ILK
Sbjct: 199 GTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCS 258
Query: 794 IPWPEGEEKLSDNAQSAVEILLTIDDTKR-----AGMKELKRHPLFSDVDWENLQHQTM- 847
P+P ++ AQ ++ LL D KR G +E++ HP F +DW L + +
Sbjct: 259 PPFP---PRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIP 315
Query: 848 -PFIPQPDDETDTSYF 862
PF PQ E D F
Sbjct: 316 APFRPQIRSELDVGNF 331
Score = 62.8 bits (151), Expect = 1e-09
Identities = 38/133 (28%), Positives = 75/133 (56%), Gaps = 11/133 (8%)
Query: 53 QKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS-PFIVHLYYSLQSANNVYLVME 111
++ G+ +AVK+ +++ + Q E AL L +S P +V+L+ + YLV+E
Sbjct: 425 RQSGQEFAVKI------LSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLE 478
Query: 112 YLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRH-GIIHRDLKPDNMLISNE--- 167
L GG++ + +F E A + + + A+ ++H G++HRDLKP+N+L +++
Sbjct: 479 LLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPG 538
Query: 168 GHIKLTDFGLSKV 180
+K+ DFG +++
Sbjct: 539 APVKIIDFGFARL 551
Score = 43.5 bits (101), Expect = 9e-04
Identities = 32/98 (32%), Positives = 49/98 (50%), Gaps = 8/98 (8%)
Query: 740 TPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQ----QVFQNILK---- 791
T Y APELL + + + D W+LGV L+ L+G PF + Q Q + + K
Sbjct: 566 TLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREG 625
Query: 792 RDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELK 829
R E + +S+ A+ V LLT+D KR ++ L+
Sbjct: 626 RFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLR 663
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 128 bits (322), Expect = 2e-29
Identities = 68/162 (41%), Positives = 108/162 (66%), Gaps = 7/162 (4%)
Query: 31 SIEEFSIVKPISRGAFGKVYL-----GQKGGKLYAVKVVKKADMINKNMTHQ-VQAERDA 84
S+E F ++K + GA+GKV+L G GKLYA+KV++KA ++ + T + + ER
Sbjct: 29 SVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSV 88
Query: 85 LALSK-SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALA 143
L L + +PF+V L+Y+ Q+ ++L+++Y+ GG++ + L+ YF E Y E+ LA
Sbjct: 89 LELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLA 148
Query: 144 LDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRD 185
L++LH+ GII+RDLK +N+L+ +EGHI LTDFGLSK L +
Sbjct: 149 LEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEE 190
Score = 84.7 bits (208), Expect = 3e-16
Identities = 53/136 (38%), Positives = 73/136 (53%), Gaps = 15/136 (11%)
Query: 739 GTPDYLAPELLLGRA-HGPAVDWWALGVCLFEFLTGIPPFNDE----TPQQVFQNILKRD 793
GT +Y+APE++ + HG AVDWW+LG+ LFE LTG PF E T +V + ILK
Sbjct: 199 GTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCS 258
Query: 794 IPWPEGEEKLSDNAQSAVEILLTIDDTKR-----AGMKELKRHPLFSDVDWENLQHQTM- 847
P+P ++ AQ ++ LL D KR G +E++ HP F +DW L + +
Sbjct: 259 PPFP---PRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIP 315
Query: 848 -PFIPQPDDETDTSYF 862
PF PQ E D F
Sbjct: 316 APFRPQIRSELDVGNF 331
Score = 62.8 bits (151), Expect = 1e-09
Identities = 38/133 (28%), Positives = 75/133 (56%), Gaps = 11/133 (8%)
Query: 53 QKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS-PFIVHLYYSLQSANNVYLVME 111
++ G+ +AVK+ +++ + Q E AL L +S P +V+L+ + YLV+E
Sbjct: 431 RQSGQEFAVKI------LSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLE 484
Query: 112 YLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRH-GIIHRDLKPDNMLISNE--- 167
L GG++ + +F E A + + + A+ ++H G++HRDLKP+N+L +++
Sbjct: 485 LLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPG 544
Query: 168 GHIKLTDFGLSKV 180
+K+ DFG +++
Sbjct: 545 APVKIIDFGFARL 557
Score = 43.5 bits (101), Expect = 9e-04
Identities = 32/98 (32%), Positives = 49/98 (50%), Gaps = 8/98 (8%)
Query: 740 TPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQ----QVFQNILK---- 791
T Y APELL + + + D W+LGV L+ L+G PF + Q Q + + K
Sbjct: 572 TLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREG 631
Query: 792 RDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELK 829
R E + +S+ A+ V LLT+D KR ++ L+
Sbjct: 632 RFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLR 669
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 128 bits (321), Expect = 3e-29
Identities = 66/146 (45%), Positives = 97/146 (66%), Gaps = 3/146 (2%)
Query: 33 EEFSIVKPISRGAFGKVYLGQKGG--KLYAVKVVKKADMINKNMTHQVQAERDALALSKS 90
E++ +VK I RGAFG+V L + K+YA+K++ K +MI ++ + ERD +A + S
Sbjct: 74 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 133
Query: 91 PFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRH 150
P++V L+Y+ Q +Y+VMEY+ GGD+ +L+ Y E+ A Y +EV LALD +H
Sbjct: 134 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWARFYTAEVVLALDAIHSM 192
Query: 151 GIIHRDLKPDNMLISNEGHIKLTDFG 176
G IHRD+KPDNML+ GH+KL DFG
Sbjct: 193 GFIHRDVKPDNMLLDKSGHLKLADFG 218
Score = 74.7 bits (182), Expect = 3e-13
Identities = 43/136 (31%), Positives = 74/136 (54%), Gaps = 11/136 (8%)
Query: 738 LGTPDYLAPELLLGRA----HGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNIL--K 791
+GTPDY++PE+L + +G DWW++GV L+E L G PF ++ + I+ K
Sbjct: 235 VGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHK 294
Query: 792 RDIPWPEGEEKLSDNAQSAVEILLTIDDTK--RAGMKELKRHPLFSDVD--WENLQHQTM 847
+ +P+ + +S A++ + LT + + R G++E+KRH F + WE L+
Sbjct: 295 NSLTFPD-DNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVA 353
Query: 848 PFIPQPDDETDTSYFE 863
P +P + DTS F+
Sbjct: 354 PVVPDLSSDIDTSNFD 369
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 125 bits (313), Expect = 2e-28
Identities = 65/155 (41%), Positives = 102/155 (65%), Gaps = 7/155 (4%)
Query: 32 IEEFSIVKPISRGAFGKVYL-----GQKGGKLYAVKVVKKADMINK-NMTHQVQAERDAL 85
IE F ++K + GA+GKV+L G GKLYA+KV+KKA ++ K T + ER L
Sbjct: 46 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 105
Query: 86 A-LSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALAL 144
+ +SPF+V L+Y+ Q+ ++L+++Y+ GG++ + L F E Y+ E+ LAL
Sbjct: 106 EHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLAL 165
Query: 145 DYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSK 179
++LH+ GII+RD+K +N+L+ + GH+ LTDFGLSK
Sbjct: 166 EHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSK 200
Score = 81.3 bits (199), Expect = 4e-15
Identities = 52/153 (33%), Positives = 80/153 (52%), Gaps = 16/153 (10%)
Query: 739 GTPDYLAPELLLG--RAHGPAVDWWALGVCLFEFLTGIPPF----NDETPQQVFQNILKR 792
GT +Y+AP+++ G H AVDWW+LGV ++E LTG PF + ++ + ILK
Sbjct: 215 GTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKS 274
Query: 793 DIPWPEGEEKLSDNAQSAVEILLTIDDTKRAG-----MKELKRHPLFSDVDWENLQHQTM 847
+ P+P +++S A+ ++ LL D KR G E+K H F ++W++L + +
Sbjct: 275 EPPYP---QEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKV 331
Query: 848 --PFIPQPDDETDTSYFEARNTAQHLTVSGFSL 878
PF P DE D S F T T S +L
Sbjct: 332 PAPFKPVIRDELDVSNFAEEFTEMDPTYSPAAL 364
Score = 58.5 bits (140), Expect = 3e-08
Identities = 39/125 (31%), Positives = 65/125 (52%), Gaps = 9/125 (7%)
Query: 39 KPISRGAFG--KVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS-PFIVH 95
KP+ G+F + + +K + +AVK+ I+K M Q E AL L + P IV
Sbjct: 430 KPLGEGSFSICRKCVHKKSNQAFAVKI------ISKRMEANTQKEITALKLCEGHPNIVK 483
Query: 96 LYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHR 155
L+ + +LVME L GG++ + +F E A + ++ A+ ++H G++HR
Sbjct: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
Query: 156 DLKPD 160
DLKP+
Sbjct: 544 DLKPE 548
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 125 bits (313), Expect = 2e-28
Identities = 65/155 (41%), Positives = 102/155 (65%), Gaps = 7/155 (4%)
Query: 32 IEEFSIVKPISRGAFGKVYL-----GQKGGKLYAVKVVKKADMINK-NMTHQVQAERDAL 85
IE F ++K + GA+GKV+L G GKLYA+KV+KKA ++ K T + ER L
Sbjct: 46 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 105
Query: 86 A-LSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALAL 144
+ +SPF+V L+Y+ Q+ ++L+++Y+ GG++ + L F E Y+ E+ LAL
Sbjct: 106 EHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLAL 165
Query: 145 DYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSK 179
++LH+ GII+RD+K +N+L+ + GH+ LTDFGLSK
Sbjct: 166 EHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSK 200
Score = 81.3 bits (199), Expect = 4e-15
Identities = 52/153 (33%), Positives = 80/153 (52%), Gaps = 16/153 (10%)
Query: 739 GTPDYLAPELLLG--RAHGPAVDWWALGVCLFEFLTGIPPF----NDETPQQVFQNILKR 792
GT +Y+AP+++ G H AVDWW+LGV ++E LTG PF + ++ + ILK
Sbjct: 215 GTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKS 274
Query: 793 DIPWPEGEEKLSDNAQSAVEILLTIDDTKRAG-----MKELKRHPLFSDVDWENLQHQTM 847
+ P+P +++S A+ ++ LL D KR G E+K H F ++W++L + +
Sbjct: 275 EPPYP---QEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKV 331
Query: 848 --PFIPQPDDETDTSYFEARNTAQHLTVSGFSL 878
PF P DE D S F T T S +L
Sbjct: 332 PAPFKPVIRDELDVSNFAEEFTEMDPTYSPAAL 364
Score = 72.8 bits (177), Expect = 1e-12
Identities = 47/148 (31%), Positives = 80/148 (54%), Gaps = 12/148 (8%)
Query: 39 KPISRGAFG--KVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS-PFIVH 95
KP+ G+F + + +K + +AVK+ I+K M Q E AL L + P IV
Sbjct: 430 KPLGEGSFSICRKCVHKKSNQAFAVKI------ISKRMEANTQKEITALKLCEGHPNIVK 483
Query: 96 LYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHR 155
L+ + +LVME L GG++ + +F E A + ++ A+ ++H G++HR
Sbjct: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
Query: 156 DLKPDNMLISNEG---HIKLTDFGLSKV 180
DLKP+N+L ++E IK+ DFG +++
Sbjct: 544 DLKPENLLFTDENDNLEIKIIDFGFARL 571
Score = 50.4 bits (119), Expect = 7e-06
Identities = 37/116 (31%), Positives = 56/116 (48%), Gaps = 14/116 (12%)
Query: 734 DGRILGTP----DYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDE-------TP 782
D + L TP Y APELL + + D W+LGV L+ L+G PF +
Sbjct: 575 DNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSA 634
Query: 783 QQVFQNILKRDIPWPEGE--EKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSD 836
++ + I K D + EGE + +S A+ ++ LLT+D KR M L+ + D
Sbjct: 635 VEIMKKIKKGDFSF-EGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQD 689
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 124 bits (310), Expect = 5e-28
Identities = 70/186 (37%), Positives = 105/186 (56%), Gaps = 3/186 (1%)
Query: 18 EEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYLGQKGGK--LYAVKVVKKADMINKNMT 75
E G R K ++EF+ +K + +G+FGKV L + GK +YAVKV+KK ++ +
Sbjct: 391 ENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDV 450
Query: 76 HQVQAERDALALS-KSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAV 134
E+ LAL+ K P++ LY Q+ + ++ VMEY+ GGD+ + FDE +
Sbjct: 451 DCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSR 510
Query: 135 KYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTT 194
Y +EV AL +LH+HG+I+RDLK DN+L+ EGH KL DFG+ K + + T
Sbjct: 511 FYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGT 570
Query: 195 PSMAKP 200
P P
Sbjct: 571 PDYIAP 576
Score = 94.7 bits (234), Expect = 3e-19
Identities = 49/134 (36%), Positives = 77/134 (57%), Gaps = 12/134 (8%)
Query: 739 GTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPE 798
GTPDY+APE+L +GP+VDWWALGV ++E + G PPF + +F++IL D+ +P
Sbjct: 569 GTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPV 628
Query: 799 GEEKLSDNAQSAVEILLTIDDTKRAGM-------KELKRHPLFSDVDWENLQHQTM--PF 849
LS A S ++ +T + KR G +K+HP F ++DW L+ + + PF
Sbjct: 629 W---LSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPF 685
Query: 850 IPQPDDETDTSYFE 863
P+ + D + F+
Sbjct: 686 KPRIKTKRDVNNFD 699
>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
Length = 639
Score = 122 bits (306), Expect = 1e-27
Identities = 65/172 (37%), Positives = 105/172 (61%), Gaps = 4/172 (2%)
Query: 33 EEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 90
++F I+K I RGAF +V + + + G++YA+K++ K DM+ + + ERD L
Sbjct: 79 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 138
Query: 91 PFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGY-FDEEMAVKYISEVALALDYLHR 149
+I L+++ Q N +YLVMEY +GGD+ +LL +G EMA Y++E+ +A+D +HR
Sbjct: 139 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 198
Query: 150 HGIIHRDLKPDNMLISNEGHIKLTDFG-LSKVTLNRDINMMDILTTPSMAKP 200
G +HRD+KPDN+L+ GHI+L DFG K+ + + + + TP P
Sbjct: 199 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 250
Score = 84.7 bits (208), Expect = 3e-16
Identities = 48/149 (32%), Positives = 75/149 (50%), Gaps = 11/149 (7%)
Query: 738 LGTPDYLAPELLLG-------RAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNIL 790
+GTPDYL+PE+L ++GP DWWALGV +E G PF ++ + + I+
Sbjct: 242 VGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIV 301
Query: 791 --KRDIPWPEGEEKLSDNAQSAVEILLTIDDTK--RAGMKELKRHPLFSDVDWENLQHQT 846
K + P +E + + A+ ++ LL +T+ R G + + HP F +DW+ L+
Sbjct: 302 HYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSV 361
Query: 847 MPFIPQPDDETDTSYFEARNTAQHLTVSG 875
PF P + TDT F+ VSG
Sbjct: 362 PPFTPDFEGATDTCNFDLVEDGLTAMVSG 390
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 122 bits (306), Expect = 1e-27
Identities = 65/172 (37%), Positives = 105/172 (61%), Gaps = 4/172 (2%)
Query: 33 EEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 90
++F I+K I RGAF +V + + + G++YA+K++ K DM+ + + ERD L
Sbjct: 69 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 128
Query: 91 PFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGY-FDEEMAVKYISEVALALDYLHR 149
+I L+++ Q N +YLVMEY +GGD+ +LL +G EMA Y++E+ +A+D +HR
Sbjct: 129 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 188
Query: 150 HGIIHRDLKPDNMLISNEGHIKLTDFG-LSKVTLNRDINMMDILTTPSMAKP 200
G +HRD+KPDN+L+ GHI+L DFG K+ + + + + TP P
Sbjct: 189 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
Score = 83.6 bits (205), Expect = 7e-16
Identities = 45/137 (32%), Positives = 72/137 (52%), Gaps = 11/137 (8%)
Query: 738 LGTPDYLAPELLLG-------RAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNIL 790
+GTPDYL+PE+L ++GP DWWALGV +E G PF ++ + + I+
Sbjct: 232 VGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIV 291
Query: 791 --KRDIPWPEGEEKLSDNAQSAVEILLTIDDTK--RAGMKELKRHPLFSDVDWENLQHQT 846
K + P +E + + A+ ++ LL +T+ R G + + HP F +DW+ L+
Sbjct: 292 HYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSV 351
Query: 847 MPFIPQPDDETDTSYFE 863
PF P + TDT F+
Sbjct: 352 PPFTPDFEGATDTCNFD 368
>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
Length = 624
Score = 122 bits (306), Expect = 1e-27
Identities = 65/172 (37%), Positives = 105/172 (61%), Gaps = 4/172 (2%)
Query: 33 EEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 90
++F I+K I RGAF +V + + + G++YA+K++ K DM+ + + ERD L
Sbjct: 69 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 128
Query: 91 PFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGY-FDEEMAVKYISEVALALDYLHR 149
+I L+++ Q N +YLVMEY +GGD+ +LL +G EMA Y++E+ +A+D +HR
Sbjct: 129 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 188
Query: 150 HGIIHRDLKPDNMLISNEGHIKLTDFG-LSKVTLNRDINMMDILTTPSMAKP 200
G +HRD+KPDN+L+ GHI+L DFG K+ + + + + TP P
Sbjct: 189 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
Score = 83.6 bits (205), Expect = 7e-16
Identities = 45/137 (32%), Positives = 72/137 (52%), Gaps = 11/137 (8%)
Query: 738 LGTPDYLAPELLLG-------RAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNIL 790
+GTPDYL+PE+L ++GP DWWALGV +E G PF ++ + + I+
Sbjct: 232 VGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIV 291
Query: 791 --KRDIPWPEGEEKLSDNAQSAVEILLTIDDTK--RAGMKELKRHPLFSDVDWENLQHQT 846
K + P +E + + A+ ++ LL +T+ R G + + HP F +DW+ L+
Sbjct: 292 HYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSV 351
Query: 847 MPFIPQPDDETDTSYFE 863
PF P + TDT F+
Sbjct: 352 PPFTPDFEGATDTCNFD 368
>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
sapiens]
Length = 629
Score = 122 bits (306), Expect = 1e-27
Identities = 65/172 (37%), Positives = 105/172 (61%), Gaps = 4/172 (2%)
Query: 33 EEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 90
++F I+K I RGAF +V + + + G++YA+K++ K DM+ + + ERD L
Sbjct: 69 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 128
Query: 91 PFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGY-FDEEMAVKYISEVALALDYLHR 149
+I L+++ Q N +YLVMEY +GGD+ +LL +G EMA Y++E+ +A+D +HR
Sbjct: 129 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 188
Query: 150 HGIIHRDLKPDNMLISNEGHIKLTDFG-LSKVTLNRDINMMDILTTPSMAKP 200
G +HRD+KPDN+L+ GHI+L DFG K+ + + + + TP P
Sbjct: 189 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
Score = 84.7 bits (208), Expect = 3e-16
Identities = 48/149 (32%), Positives = 75/149 (50%), Gaps = 11/149 (7%)
Query: 738 LGTPDYLAPELLLG-------RAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNIL 790
+GTPDYL+PE+L ++GP DWWALGV +E G PF ++ + + I+
Sbjct: 232 VGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIV 291
Query: 791 --KRDIPWPEGEEKLSDNAQSAVEILLTIDDTK--RAGMKELKRHPLFSDVDWENLQHQT 846
K + P +E + + A+ ++ LL +T+ R G + + HP F +DW+ L+
Sbjct: 292 HYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSV 351
Query: 847 MPFIPQPDDETDTSYFEARNTAQHLTVSG 875
PF P + TDT F+ VSG
Sbjct: 352 PPFTPDFEGATDTCNFDLVEDGLTAMVSG 380
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 122 bits (305), Expect = 2e-27
Identities = 63/172 (36%), Positives = 101/172 (58%), Gaps = 3/172 (1%)
Query: 32 IEEFSIVKPISRGAFGKVYLGQKGG--KLYAVKVVKKADMINKNMTHQVQAERDALAL-S 88
+ +F+ + + +G+FGKV L + G +LYA+K++KK +I + E+ LAL
Sbjct: 336 LTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD 395
Query: 89 KSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLH 148
K PF+ L+ Q+ + +Y VMEY+ GGD+ + G F E AV Y +E+++ L +LH
Sbjct: 396 KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLH 455
Query: 149 RHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTPSMAKP 200
+ GII+RDLK DN+++ +EGHIK+ DFG+ K + + TP P
Sbjct: 456 KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAP 507
Score = 93.6 bits (231), Expect = 7e-19
Identities = 46/121 (38%), Positives = 75/121 (61%), Gaps = 10/121 (8%)
Query: 739 GTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPE 798
GTPDY+APE++ + +G +VDWWA GV L+E L G PPF+ E ++FQ+I++ ++ +P
Sbjct: 500 GTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYP- 558
Query: 799 GEEKLSDNAQSAVEILLTIDDTKRAGM-----KELKRHPLFSDVDWENLQHQTM--PFIP 851
+ LS A S + L+T KR G ++++ H F +DWE L+++ + PF P
Sbjct: 559 --KSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKP 616
Query: 852 Q 852
+
Sbjct: 617 K 617
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 121 bits (304), Expect = 2e-27
Identities = 69/181 (38%), Positives = 106/181 (58%), Gaps = 7/181 (3%)
Query: 34 EFSIVKPISRGAFGKVYLGQKGGK--LYAVKVVKKADMINKNMTHQVQAERDALALS-KS 90
+F +K I +G+FGKV L + + YAVKV++K ++ K + +ER+ L + K
Sbjct: 97 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 156
Query: 91 PFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRH 150
PF+V L++S Q+A+ +Y V++Y+ GG++ L F E A Y +E+A AL YLH
Sbjct: 157 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 216
Query: 151 GIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTPSMAKP----RQDYSR 206
I++RDLKP+N+L+ ++GHI LTDFGL K + + TP P +Q Y R
Sbjct: 217 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 276
Query: 207 T 207
T
Sbjct: 277 T 277
Score = 90.1 bits (222), Expect = 8e-18
Identities = 49/137 (35%), Positives = 78/137 (56%), Gaps = 9/137 (6%)
Query: 739 GTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPE 798
GTP+YLAPE+L + + VDWW LG L+E L G+PPF +++ NIL + + +
Sbjct: 259 GTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPL---Q 315
Query: 799 GEEKLSDNAQSAVEILLTIDDTKRAGMK----ELKRHPLFSDVDWENLQHQ--TMPFIPQ 852
+ ++++A+ +E LL D TKR G K E+K H FS ++W++L ++ T PF P
Sbjct: 316 LKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPN 375
Query: 853 PDDETDTSYFEARNTAQ 869
D +F+ T +
Sbjct: 376 VSGPNDLRHFDPEFTEE 392
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,766,127
Number of Sequences: 37866
Number of extensions: 1614392
Number of successful extensions: 5684
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 732
Number of HSP's successfully gapped in prelim test: 124
Number of HSP's that attempted gapping in prelim test: 3454
Number of HSP's gapped (non-prelim): 1733
length of query: 878
length of database: 18,247,518
effective HSP length: 111
effective length of query: 767
effective length of database: 14,044,392
effective search space: 10772048664
effective search space used: 10772048664
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.