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Search of human proteins with 171184451
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|171184451 centrosome-associated protein 350 [Homo sapiens]
(3117 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|171184451 centrosome-associated protein 350 [Homo sapiens] 6113 0.0
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 103 2e-21
gi|38044112 restin isoform b [Homo sapiens] 100 2e-20
gi|4506751 restin isoform a [Homo sapiens] 99 7e-20
gi|116008447 CAP-GLY domain containing linker protein 2 isoform ... 98 1e-19
gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2... 96 4e-19
gi|31982881 CAP-GLY domain containing linker protein family, mem... 94 2e-18
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 92 1e-17
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 92 1e-17
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 92 1e-17
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 92 1e-17
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 92 1e-17
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 92 1e-17
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 92 1e-17
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 92 1e-17
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 90 3e-17
gi|18496983 CAP-GLY domain containing linker protein 3 [Homo sap... 90 4e-17
gi|148746195 trichohyalin [Homo sapiens] 84 2e-15
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 84 2e-15
gi|71061468 centromere protein E [Homo sapiens] 83 4e-15
gi|55770834 centromere protein F [Homo sapiens] 83 4e-15
gi|42794779 myosin 18A isoform b [Homo sapiens] 81 1e-14
gi|28416946 myosin 18A isoform a [Homo sapiens] 81 2e-14
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 79 7e-14
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 79 7e-14
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 79 7e-14
gi|118498356 kinectin 1 isoform a [Homo sapiens] 78 2e-13
gi|33620775 kinectin 1 isoform a [Homo sapiens] 78 2e-13
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 77 2e-13
gi|21735548 centrosomal protein 2 [Homo sapiens] 77 3e-13
>gi|171184451 centrosome-associated protein 350 [Homo sapiens]
Length = 3117
Score = 6113 bits (15860), Expect = 0.0
Identities = 3117/3117 (100%), Positives = 3117/3117 (100%)
Query: 1 MRSSKSKEVPLPNPRNSQSKDTVQADITTSWDALSQTKAALRHIENKLEVAPTSTAVCDS 60
MRSSKSKEVPLPNPRNSQSKDTVQADITTSWDALSQTKAALRHIENKLEVAPTSTAVCDS
Sbjct: 1 MRSSKSKEVPLPNPRNSQSKDTVQADITTSWDALSQTKAALRHIENKLEVAPTSTAVCDS 60
Query: 61 VMDTKKSSTSATRKISRKDGRYLDDSWVNAPISKSTKSRKEKSRSPLRATTLESNVKKNN 120
VMDTKKSSTSATRKISRKDGRYLDDSWVNAPISKSTKSRKEKSRSPLRATTLESNVKKNN
Sbjct: 61 VMDTKKSSTSATRKISRKDGRYLDDSWVNAPISKSTKSRKEKSRSPLRATTLESNVKKNN 120
Query: 121 RVEFREPLVSYREIHGAPSNFSSSHLESKHVYCVDVNEEKTESGNWMIGSREERNIRSCD 180
RVEFREPLVSYREIHGAPSNFSSSHLESKHVYCVDVNEEKTESGNWMIGSREERNIRSCD
Sbjct: 121 RVEFREPLVSYREIHGAPSNFSSSHLESKHVYCVDVNEEKTESGNWMIGSREERNIRSCD 180
Query: 181 FESSQSSVINDTVVRFLNDRPAIDALQNSECLIRMGASMRTEEEMPNRTKGSENNLKLSV 240
FESSQSSVINDTVVRFLNDRPAIDALQNSECLIRMGASMRTEEEMPNRTKGSENNLKLSV
Sbjct: 181 FESSQSSVINDTVVRFLNDRPAIDALQNSECLIRMGASMRTEEEMPNRTKGSENNLKLSV 240
Query: 241 NNMAHDTDPKALRLTDSSPSSTSTSNSQRLDILKRRQHDVKLEKLKERIRKQWEHSEETN 300
NNMAHDTDPKALRLTDSSPSSTSTSNSQRLDILKRRQHDVKLEKLKERIRKQWEHSEETN
Sbjct: 241 NNMAHDTDPKALRLTDSSPSSTSTSNSQRLDILKRRQHDVKLEKLKERIRKQWEHSEETN 300
Query: 301 GRGQKLGHIDHPVMVVNVDNSVTAKVRKVATAPPAPAYKGFNPSETKIRTPDGKVWQEAE 360
GRGQKLGHIDHPVMVVNVDNSVTAKVRKVATAPPAPAYKGFNPSETKIRTPDGKVWQEAE
Sbjct: 301 GRGQKLGHIDHPVMVVNVDNSVTAKVRKVATAPPAPAYKGFNPSETKIRTPDGKVWQEAE 360
Query: 361 FQNMSRELYRDLALHFADDISIKEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHL 420
FQNMSRELYRDLALHFADDISIKEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHL
Sbjct: 361 FQNMSRELYRDLALHFADDISIKEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHL 420
Query: 421 ISTSSWRDGQKLVKKILGPAPRMEPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVL 480
ISTSSWRDGQKLVKKILGPAPRMEPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVL
Sbjct: 421 ISTSSWRDGQKLVKKILGPAPRMEPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVL 480
Query: 481 HRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDST 540
HRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDST
Sbjct: 481 HRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDST 540
Query: 541 AHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYI 600
AHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYI
Sbjct: 541 AHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYI 600
Query: 601 VRQQEERKRKQNEEKKAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQET 660
VRQQEERKRKQNEEKKAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQET
Sbjct: 601 VRQQEERKRKQNEEKKAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQET 660
Query: 661 YSKLLLEKTLLEEPSHQHVTQETQAKPGYQPSGESDKENKVQERPPSASSSSDMSLSEPP 720
YSKLLLEKTLLEEPSHQHVTQETQAKPGYQPSGESDKENKVQERPPSASSSSDMSLSEPP
Sbjct: 661 YSKLLLEKTLLEEPSHQHVTQETQAKPGYQPSGESDKENKVQERPPSASSSSDMSLSEPP 720
Query: 721 QPLARKDLMESTWMQPERLSPQVHHSQPQPFAGTAGSLLSHLLSLEHVGILHKDFESILP 780
QPLARKDLMESTWMQPERLSPQVHHSQPQPFAGTAGSLLSHLLSLEHVGILHKDFESILP
Sbjct: 721 QPLARKDLMESTWMQPERLSPQVHHSQPQPFAGTAGSLLSHLLSLEHVGILHKDFESILP 780
Query: 781 TRKNHNMASRPLTFTPQPYVTSPAAYTDALLKPSASQYKSKLDRIEALKATAASLSSRIE 840
TRKNHNMASRPLTFTPQPYVTSPAAYTDALLKPSASQYKSKLDRIEALKATAASLSSRIE
Sbjct: 781 TRKNHNMASRPLTFTPQPYVTSPAAYTDALLKPSASQYKSKLDRIEALKATAASLSSRIE 840
Query: 841 SEAKKLAGASINYGSAWNTEYDVQQAPQEDGPWTKAVTPPVKDDNEDVFSARIQKMLGSC 900
SEAKKLAGASINYGSAWNTEYDVQQAPQEDGPWTKAVTPPVKDDNEDVFSARIQKMLGSC
Sbjct: 841 SEAKKLAGASINYGSAWNTEYDVQQAPQEDGPWTKAVTPPVKDDNEDVFSARIQKMLGSC 900
Query: 901 VSHATFDDDLPGVGNLSEFKKLPEMIRPQSAISSFRVRSPGPKPEGLLAQLCKRQTDSSS 960
VSHATFDDDLPGVGNLSEFKKLPEMIRPQSAISSFRVRSPGPKPEGLLAQLCKRQTDSSS
Sbjct: 901 VSHATFDDDLPGVGNLSEFKKLPEMIRPQSAISSFRVRSPGPKPEGLLAQLCKRQTDSSS 960
Query: 961 SDMQACSQDKAKISLGSSIDSVSEGPLLSEGSLSEEEGDQDGQPLLKVAEILKEKEFCPG 1020
SDMQACSQDKAKISLGSSIDSVSEGPLLSEGSLSEEEGDQDGQPLLKVAEILKEKEFCPG
Sbjct: 961 SDMQACSQDKAKISLGSSIDSVSEGPLLSEGSLSEEEGDQDGQPLLKVAEILKEKEFCPG 1020
Query: 1021 ERNSYEPIKEFQKEAEKFLPLFGHIGGTQSKGPWEELAKGSPHSVINIFTKSYQLYGKGF 1080
ERNSYEPIKEFQKEAEKFLPLFGHIGGTQSKGPWEELAKGSPHSVINIFTKSYQLYGKGF
Sbjct: 1021 ERNSYEPIKEFQKEAEKFLPLFGHIGGTQSKGPWEELAKGSPHSVINIFTKSYQLYGKGF 1080
Query: 1081 EDKLDRGTSTSRPLNATATPLSGVSYEDDFVSSPGTGTSTEKKSTLEPHSTLSPQEDHSN 1140
EDKLDRGTSTSRPLNATATPLSGVSYEDDFVSSPGTGTSTEKKSTLEPHSTLSPQEDHSN
Sbjct: 1081 EDKLDRGTSTSRPLNATATPLSGVSYEDDFVSSPGTGTSTEKKSTLEPHSTLSPQEDHSN 1140
Query: 1141 RKSAYDPSSVDVTSQHSSGAQSAASSRSSTSSKGKKGKKEKTEWLDSFTGNVQNSLLDEE 1200
RKSAYDPSSVDVTSQHSSGAQSAASSRSSTSSKGKKGKKEKTEWLDSFTGNVQNSLLDEE
Sbjct: 1141 RKSAYDPSSVDVTSQHSSGAQSAASSRSSTSSKGKKGKKEKTEWLDSFTGNVQNSLLDEE 1200
Query: 1201 KAERGSHQGKKSGTSSKLSVKDFEQTLDTDSTLEDLSGHSVSVSSDKGRSQKTPTSPLSP 1260
KAERGSHQGKKSGTSSKLSVKDFEQTLDTDSTLEDLSGHSVSVSSDKGRSQKTPTSPLSP
Sbjct: 1201 KAERGSHQGKKSGTSSKLSVKDFEQTLDTDSTLEDLSGHSVSVSSDKGRSQKTPTSPLSP 1260
Query: 1261 SSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASRTTTENMAPIPGSKRF 1320
SSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASRTTTENMAPIPGSKRF
Sbjct: 1261 SSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASRTTTENMAPIPGSKRF 1320
Query: 1321 SPAGLHHRMAAELSYLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDL 1380
SPAGLHHRMAAELSYLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDL
Sbjct: 1321 SPAGLHHRMAAELSYLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDL 1380
Query: 1381 ALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSE 1440
ALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSE
Sbjct: 1381 ALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSE 1440
Query: 1441 TARLTTDAARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDR 1500
TARLTTDAARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDR
Sbjct: 1441 TARLTTDAARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDR 1500
Query: 1501 KSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKEN 1560
KSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKEN
Sbjct: 1501 KSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKEN 1560
Query: 1561 EKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDEIE 1620
EKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDEIE
Sbjct: 1561 EKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDEIE 1620
Query: 1621 EQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFT 1680
EQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFT
Sbjct: 1621 EQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFT 1680
Query: 1681 MEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLR 1740
MEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLR
Sbjct: 1681 MEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLR 1740
Query: 1741 KKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGE 1800
KKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGE
Sbjct: 1741 KKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGE 1800
Query: 1801 SKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTK 1860
SKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTK
Sbjct: 1801 SKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTK 1860
Query: 1861 REQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTE 1920
REQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTE
Sbjct: 1861 REQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTE 1920
Query: 1921 QKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMIC 1980
QKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMIC
Sbjct: 1921 QKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMIC 1980
Query: 1981 SQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQ 2040
SQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQ
Sbjct: 1981 SQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQ 2040
Query: 2041 SETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEF 2100
SETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEF
Sbjct: 2041 SETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEF 2100
Query: 2101 IKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRG 2160
IKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRG
Sbjct: 2101 IKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRG 2160
Query: 2161 SLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESG 2220
SLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESG
Sbjct: 2161 SLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESG 2220
Query: 2221 DSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGK 2280
DSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGK
Sbjct: 2221 DSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGK 2280
Query: 2281 SDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNH 2340
SDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNH
Sbjct: 2281 SDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNH 2340
Query: 2341 SPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVS 2400
SPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVS
Sbjct: 2341 SPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVS 2400
Query: 2401 SLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKS 2460
SLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKS
Sbjct: 2401 SLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKS 2460
Query: 2461 PTELMKSKERSDVEHEQQVTESPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETS 2520
PTELMKSKERSDVEHEQQVTESPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETS
Sbjct: 2461 PTELMKSKERSDVEHEQQVTESPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETS 2520
Query: 2521 FAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDE 2580
FAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDE
Sbjct: 2521 FAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDE 2580
Query: 2581 DCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNV 2640
DCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNV
Sbjct: 2581 DCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNV 2640
Query: 2641 QDISGVLEAHVHQQSSVDSQISSKENKDLISDATEKVSIAAEDDTLDNTFSEELEKQQQF 2700
QDISGVLEAHVHQQSSVDSQISSKENKDLISDATEKVSIAAEDDTLDNTFSEELEKQQQF
Sbjct: 2641 QDISGVLEAHVHQQSSVDSQISSKENKDLISDATEKVSIAAEDDTLDNTFSEELEKQQQF 2700
Query: 2701 TEEEDNLYAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLK 2760
TEEEDNLYAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLK
Sbjct: 2701 TEEEDNLYAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLK 2760
Query: 2761 VFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSE 2820
VFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSE
Sbjct: 2761 VFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSE 2820
Query: 2821 LEDEKEEISSPDMCPRPESPVFGASGQEELAKRLAELELSREFLSALGDDQDWFDEDFGL 2880
LEDEKEEISSPDMCPRPESPVFGASGQEELAKRLAELELSREFLSALGDDQDWFDEDFGL
Sbjct: 2821 LEDEKEEISSPDMCPRPESPVFGASGQEELAKRLAELELSREFLSALGDDQDWFDEDFGL 2880
Query: 2881 SSSHKIQKNKAEETIVPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKEL 2940
SSSHKIQKNKAEETIVPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKEL
Sbjct: 2881 SSSHKIQKNKAEETIVPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKEL 2940
Query: 2941 GHDLHSISIPTKLLGCASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMK 3000
GHDLHSISIPTKLLGCASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMK
Sbjct: 2941 GHDLHSISIPTKLLGCASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMK 3000
Query: 3001 PCRINSSYFRRVKNPNNLDEIKSFIASEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVD 3060
PCRINSSYFRRVKNPNNLDEIKSFIASEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVD
Sbjct: 3001 PCRINSSYFRRVKNPNNLDEIKSFIASEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVD 3060
Query: 3061 HILVQELHEEEAQWVNYDEDELCVKMQLADGIFETLIKDTIDVLNQISEKQGRMLLV 3117
HILVQELHEEEAQWVNYDEDELCVKMQLADGIFETLIKDTIDVLNQISEKQGRMLLV
Sbjct: 3061 HILVQELHEEEAQWVNYDEDELCVKMQLADGIFETLIKDTIDVLNQISEKQGRMLLV 3117
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 103 bits (258), Expect = 2e-21
Identities = 316/1637 (19%), Positives = 634/1637 (38%), Gaps = 242/1637 (14%)
Query: 1295 PLTDLNPAASRTTTENMAPIPGSKRFSPAGLHHRMAAELSYLNAIEESV-RQLSDVERVR 1353
PL L P A T E G + L +++ V RQ + ++R +
Sbjct: 247 PLPQLEPQAEVFTKEENPESDGEPVVEDG-------TSVKTLETLQQRVKRQENLLKRCK 299
Query: 1354 GISLAQQESVSLAQIIKA--QQQRHERDLALLKLKAEQEALESQ--RQLEETRNKAAQVH 1409
+ +E +L K Q+Q ER L K+K A +++ QL + +N Q+
Sbjct: 300 ETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLE 359
Query: 1410 AESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTT--DAARQICEMAELTRTHISDAV 1467
+ + +++R++ E L+ +IA +S ++TT + R+ E +E +
Sbjct: 360 QDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKA 419
Query: 1468 VASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYD 1527
+++ + + + +K + +E +R S LS+ K+ +D
Sbjct: 420 LSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMK-------- 471
Query: 1528 SYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRS 1587
K+ + + + E +E KKL E EQ++ A + S
Sbjct: 472 --------KSSEEQIAKLQKLHEKELARKEQELTKKLQTR--EREFQEQMKVALEKS--Q 519
Query: 1588 DSVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDD 1647
+ EK+ ES+ +E+E Q L SE+ R ++ +
Sbjct: 520 SEYLKISQEKEQ-----------QESLALEELELQKKAILTESENKLRDLQQEAETYRTR 568
Query: 1648 SDE-EASPEKT---TLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLR 1703
E E+S EK+ + +K+L + ++ +K MV ++ E E Q +L
Sbjct: 569 ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWT 628
Query: 1704 LREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLRLQQ------EKAEI 1757
+ + LK++ + E+ + LR+K E +K L+ K+ +++ EK ++
Sbjct: 629 EKLQVLKQQYQTEM-------EKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDV 681
Query: 1758 KRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKAT 1817
K Q ++ E +LK + ++E+ +K+K E+K+D + +
Sbjct: 682 K--QTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVD-- 737
Query: 1818 SPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMD--EKFLTKREQKLMQRRQHAEEL 1875
SI SI + K ++ +++ E L +R++ L + + H E L
Sbjct: 738 ---------------SIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782
Query: 1876 LEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLY 1935
EA+I++ E + A K + E + ++++A ++ + L
Sbjct: 783 ----------EADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLE 832
Query: 1936 SHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSL 1995
+ + E+ + + H I ++++ Q+LE S + +
Sbjct: 833 TERILLTKQVAEVEAQKKDVCTELDA---------HKIQVQDLM--QQLEKQNSEMEQKV 881
Query: 1996 PKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIR 2055
KS T V + + G+ + Q + ++ E T S E I
Sbjct: 882 -KSLTQVYESKLEDGN-KEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIH 939
Query: 2056 ALKDELR-------KRKSVVNQLKKEQKKRQKERLKAQEASLIKQLES----YDEFIKKT 2104
L +E K+ V Q KE ++ K++L QEA L K+LE+ + K+
Sbjct: 940 ILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQF 999
Query: 2105 EAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLES 2164
A++ + + + + ++K +I+ LT +HR E + S+ E + ++ + E
Sbjct: 1000 NAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRREL-NDVISIWEKKLNQQA-EE 1057
Query: 2165 IAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLE 2224
+ E + L E+ V+E +++ + E+ L+ ++ + + L+
Sbjct: 1058 LQEIHEIQLQEKEQEVAELK-----QKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQ 1112
Query: 2225 NVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVL 2284
LK+ +A L + K+ +K E+ L KS E+ F +E ++
Sbjct: 1113 EQ-----LKQKSAHVNSLAQDETKLKAHLEKLEVD------LNKSLKENTFLQEQLVELK 1161
Query: 2285 LKLVLEQGDSSEILSK--------KDLPLDSENVQKDLVGLAIENLHKSEEML------- 2329
+ ++ SE+ SK + L E K L ++E SEE+
Sbjct: 1162 MLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICC 1221
Query: 2330 --KERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAP-KEIPYSEDFEVSSFKK 2386
E + N NI S K N +S +H KE + VS
Sbjct: 1222 KKTEALLEAKTNELINISSSKT-----NAILSRISHCQHRTTKVKEALLIKTCTVS---- 1272
Query: 2387 EISAELYKDDFEVSSL-LSLRKDSQSCRDKPQPMRSSTSGATSF----------GSNE-- 2433
E+ A+L + E ++L +S ++ + +K ++S + S G N+
Sbjct: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQ 1332
Query: 2434 ---EISECLSEKSLSIHSNVHSDRLL--ELKSP----TELMKSKERSDVEHEQQVTESPS 2484
E C+++ + N+++ L+ ELK + L K +V+ + ++ S
Sbjct: 1333 AASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392
Query: 2485 LASVPTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDG 2544
A++ + + +D + L+ VQ L FK +T +K + +E N +
Sbjct: 1393 EAAISSLRKQYDEEKCE--LLDQVQD--LSFKVDT-LSKEKISALEQVDDWSNKFSEWKK 1447
Query: 2545 IAYFECKEKHGIFAPPQ-----KISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTE 2599
A + Q K E D+ +++ ++E ++R+ C E D +
Sbjct: 1448 KAQSRFTQHQNTVKELQIQLELKSKEAYEK-DEQINLLKEELDQQNKRFDCLKGEMEDDK 1506
Query: 2600 GPKDREKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDS 2659
++++ E + + ++E + + +T ++ ++ VL+ + +QQ +
Sbjct: 1507 SKMEKKESNLETELKSQTARIMELEDHITQ------KTIEIESLNEVLKNY-NQQKDI-- 1557
Query: 2660 QISSKENKDLISDATEKVSIAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPL 2719
E+K+L+ ++L+ Q+ EE+DN EA EK+ T L
Sbjct: 1558 -----EHKELV---------------------QKLQHFQELGEEKDNRVKEAEEKILT-L 1590
Query: 2720 LDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDE 2779
+ + K +LE + K + K + E++ L D L ++ +L ++K+ ++
Sbjct: 1591 ENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRL----ESESAAKLAELKRKAEQ 1646
Query: 2780 KIQLSNQELLG------DDQKKVTPQDLSQ-NVEEQSPSISGCFLSSELEDEKEEISSPD 2832
KI ++LL + KK T LS+ N + Q L +L+ + S
Sbjct: 1647 KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL 1706
Query: 2833 MCPRPESPVFGASGQEE 2849
+ PR V + QEE
Sbjct: 1707 IVPRSAKNVAAYTEQEE 1723
Score = 87.0 bits (214), Expect = 3e-16
Identities = 305/1625 (18%), Positives = 637/1625 (39%), Gaps = 244/1625 (15%)
Query: 1359 QQESVSLAQIIKAQQQRHERDLALL---------KLKAEQEAL----------ESQRQLE 1399
+ +S LA ++A++ +H +++ ++ LK +Q+AL + Q ++E
Sbjct: 584 KNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEME 643
Query: 1400 ETRNKAAQVHAESLQ-QVVQSQREVTEVLQEATCKIAAQQSETARLTTD------AARQI 1452
+ R K Q L+ + + Q + E+ ++ K+ +Q+E L+++ A ++
Sbjct: 644 KLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKL 703
Query: 1453 CEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKE 1512
E + + A + +H +Q + +K+ + K+ ++Q +
Sbjct: 704 EEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLE- 762
Query: 1513 GTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESP------SVPSCKENEKKLNG 1566
L + K+ + ++ E+ D + S G +Q S S S + K
Sbjct: 763 -LLLKERDKHLKEHQAHVENL---EADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYE 818
Query: 1567 EKIESSIDEQVQTAADDSLRSDSVPSLP-DEKDSTSIATEYSLKFDESMTEDEIEEQSFR 1625
E++ + + + L + V + +KD + + ++ + M + E +
Sbjct: 819 EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME 878
Query: 1626 SLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMVR 1685
+ S + + +D ++E K L + + + GQ K +E++
Sbjct: 879 QKVKSLT------QVYESKLEDGNKEQEQTKQILVEKENMILQMREGQ----KKEIEILT 928
Query: 1686 QYMKEEE-----MRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLR 1740
Q + +E + +++ +K K K KA+ +KK L D+ L+
Sbjct: 929 QKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLL------DQEAKLK 982
Query: 1741 KKQRGLLLRLQQEK----AEIKRLQEANKAARKER--QLILKQQEEIEKIRQTTIKLQEK 1794
K+ L L Q++ A++ + +AN A + +L Q+E+IE + + +
Sbjct: 983 KELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELND 1042
Query: 1795 LKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMD 1854
+ S E KL+ +++ L+ + E + + QK+ +
Sbjct: 1043 VISIWEKKLNQQAEE--------------LQEIHEIQLQEKEQEVAELKQKILLFGCEKE 1088
Query: 1855 E--KFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKK 1912
E K +T +++ +++ EL E ++ A + Q E + A +K + K
Sbjct: 1089 EMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLK 1148
Query: 1913 E---LEDQRTEQKEIASEEESPVPLYSHLNSE-SSIPEELGSPAVEYVPSESIGQEQPGS 1968
E L++Q E K +A E++ V S L S+ + EE S + S +++ S
Sbjct: 1149 ENTFLQEQLVELKMLAEEDKRKV---SELTSKLKTTDEEFQSLKSSHEKSNKSLEDK--S 1203
Query: 1969 PDHSILTEEM-----ICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIK 2023
+ L+EE+ IC ++ E+ + L +S + S+ SH C
Sbjct: 1204 LEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISH-----C----- 1253
Query: 2024 SHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQL--KKEQKKRQKE 2081
QH + E+L + T S++E ++R L +E Q + E+K+ Q +
Sbjct: 1254 --QHRTTKVKEALLIK----TCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIK 1307
Query: 2082 RLKAQEASLIKQLESY--------------DEFIKKTEAELSQDLETSPTAKPQIKT--- 2124
+KA SL+ + E+ + I + + ELS+++ K ++K
Sbjct: 1308 SMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKV 1367
Query: 2125 -LSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSL-----ESIAEHVDA--SLSGS 2176
+SS S K LT L+ +N SL+E E + SL E E +D LS
Sbjct: 1368 EISSLS-----KQLTDLNVQ--LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFK 1420
Query: 2177 ERSVSERSLSA------YAKRVNEWDSRTED--FQTPSPVLRSSRKIREESGDSLENVPA 2228
++S+ +SA ++ + +EW + + Q + V ++ +S ++ E
Sbjct: 1421 VDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQ 1480
Query: 2229 LHLLKE-LNATSRILDMSDGKVGESSKKSEIKEIEY-TKLKKS-----KIEDAFSKEGKS 2281
++LLKE L+ ++ D G++ + K E KE T+LK ++ED +++
Sbjct: 1481 INLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIE 1540
Query: 2282 DVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHS 2341
L VL+ + + + K+L ++ Q+ +G +N K E +Q +
Sbjct: 1541 IESLNEVLKNYNQQKDIEHKELVQKLQHFQE--LGEEKDNRVKEAEEKILTLENQVYSMK 1598
Query: 2342 PNIQSGKDIHEQKN----TKEKDLSW------SEHLFAPKEIPYSEDFEVSSFKK----- 2386
+++ K E N +KE++L SE E+ + ++++ KK
Sbjct: 1599 AELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQ 1658
Query: 2387 -----------------EISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSF 2429
E++ +L + + EV L K +S + + + S ++
Sbjct: 1659 MEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAY 1718
Query: 2430 GSNEE------ISECLSEKSLSIHSNV-HSDRLLELKSPTELMKSKERSDVEH-EQQVTE 2481
EE + + EK + N+ ++LL+ + + KE + H E +
Sbjct: 1719 TEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQ-----RVGQEKEETVSSHFEMRCQY 1773
Query: 2482 SPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNN-- 2539
L + A+ D+ +IG++Q + + S ++K G NN
Sbjct: 1774 QERLIKLEHAEAK---QHEDQSMIGHLQEELEEKNKKYSLI----VAQHVEKEGGKNNIQ 1826
Query: 2540 ------GTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYN- 2592
+D + +++ QKI + +++ E +Y+
Sbjct: 1827 AKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQA 1886
Query: 2593 -QEQNDTEGPKD------REKDVSEYFYEKSLPSV----NDIEASV----NRSRSLKIET 2637
Q+ + P + EK S K L ++ ND+E + + L E
Sbjct: 1887 LQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEI 1946
Query: 2638 DNVQDISGVLEAHVHQQSSVDSQISSKENKDLISDATEKVSIAAEDDT--LDNTFSEELE 2695
+Q +L Q+ + + +E ++ I E + + L F+ +L
Sbjct: 1947 VRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLA 2006
Query: 2696 KQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLT 2755
+++Q E ++++ LL+ E NQL ++ ++ K++ ++ E+I
Sbjct: 2007 QKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAR 2066
Query: 2756 DSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNVEEQSPSISGC 2815
+ + V+D QL++++K +K L +E G+D VT +L + +++ IS
Sbjct: 2067 EEEMTAKVRDLQTQLEELQKKYQQK--LEQEENPGND--NVTIMELQTQLAQKTTLISDS 2122
Query: 2816 FLSSE 2820
L +
Sbjct: 2123 KLKEQ 2127
Score = 81.6 bits (200), Expect = 1e-14
Identities = 265/1370 (19%), Positives = 539/1370 (39%), Gaps = 194/1370 (14%)
Query: 1689 KEEEMRAAHQSSLLRLREKALKEKTKAEL-AWLEHQKKHLRDKGEDDKMPPLRKKQRGLL 1747
KE+ RAA + L E+ + +L A ++ Q K + E++++ ++ L
Sbjct: 405 KEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQE-----L 459
Query: 1748 LRLQQEKAEIKRLQEANKAAR----KERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKL 1803
R++QE ++ + + A+ E++L K+QE +K++ + QE++K A E
Sbjct: 460 SRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQ 519
Query: 1804 DSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQ 1863
+ + + S +LE + + ++ S ++ + Q+ + R+R+ E + E+
Sbjct: 520 SEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILE-LESSLEK 578
Query: 1864 KLMQRRQHAEEL---LEWKRR---------LDAEEAEIRQMEKQALAAWDKELIKPKTPK 1911
L + + +++L LE ++ ++ + E+ ++ Q A W ++L + K
Sbjct: 579 SLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKL---QVLK 635
Query: 1912 KELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDH 1971
++ + + + +E +E+ + + ++ I EE+ +E + + E S
Sbjct: 636 QQYQTEMEKLREKCEQEKETLLKDKEIIFQAHI-EEMNEKTLEKLDVKQTELESLSSE-- 692
Query: 1972 SILTEEMICSQELESSTSPSKHSLPKSCTSV-SKQESSKGSHRTGGQCHLPIKSHQHCYS 2030
L+E + +LE S K K + +K + K H+ Q IK H+
Sbjct: 693 --LSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQ--QVDSIIKEHEVSIQ 748
Query: 2031 WSDESL--SMTQSETTSDQSD------------IEGRIRALKDELRKRKSVVNQLKK--- 2073
++++L + Q E + D +E I+ + EL++ + ++ +
Sbjct: 749 RTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQS 808
Query: 2074 ---EQKKRQKERLKAQEASLIKQLESYDEFIKKTEAEL---SQDLETSPTA-KPQIKTLS 2126
EQ K +E+L AQ + LE+ + K AE+ +D+ T A K Q++ L
Sbjct: 809 ATHEQTKAYEEQL-AQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLM 867
Query: 2127 SASEK------PKIKPLTPLHRS-------ETAKNWKSLTESE----RSRGSLESIAEHV 2169
EK K+K LT ++ S E + + L E E + R + E +
Sbjct: 868 QQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEIL 927
Query: 2170 DASLSGSERSVS------ERSLSAYAKRVNEWDSRTEDFQ--TPSPVLRSSRKIREESGD 2221
LS E S+ E K++ + + ++ Q +L K+++E
Sbjct: 928 TQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKE--- 984
Query: 2222 SLENVPALHLLKELNATSRILDMSDGKVG---------ESSKKSEIKEIEYTKLKKSKIE 2272
LEN KE +++L+M+ E+++K +I+ + T++ + ++
Sbjct: 985 -LENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESL--TEVHRRELN 1041
Query: 2273 DAFSKEGKSDVLLKLVLEQGDSSEI----LSKKDLPLDSENVQKDLVGLAIENLHKSEEM 2328
D S K KL + + EI L +K+ + + L G E ++K
Sbjct: 1042 DVISIWEK-----KLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITW 1096
Query: 2329 LKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSEDFEVSSFKKEI 2388
LKE QD + + K N+ +D + + E+ ++ + ++F +E
Sbjct: 1097 LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQ 1156
Query: 2389 SAEL----YKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEISECLSEKSL 2444
EL +D +VS L S K + ++ Q ++SS + ++ + + L
Sbjct: 1157 LVELKMLAEEDKRKVSELTSKLKTTD---EEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL 1213
Query: 2445 SIHSNV---HSDRLLELKSPTELMKSKER--------SDVEHEQQVTESPSLASVPTADE 2493
+I ++ ++ LLE K+ + S + S +H + L T E
Sbjct: 1214 AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSE 1273
Query: 2494 ----LFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFE 2549
L L + Q + + + + K A +E E G
Sbjct: 1274 LEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQA 1333
Query: 2550 CKEKHGIFAPPQKISHIPENFDDYVDINED------EDCYSDERYQCYNQEQNDTEGPKD 2603
EK +K + EN + + E+ E ++ N + ++ +
Sbjct: 1334 ASEKESCITQLKK--ELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSE 1391
Query: 2604 REKDVS----EYFYEKS--LPSVNDIEASVNRSRSLKIET-DNVQDISGVLEAHVHQQSS 2656
+E +S +Y EK L V D+ V+ KI + V D S +
Sbjct: 1392 KEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFS---EWKKK 1448
Query: 2657 VDSQISSKEN--KDLISDATEKVSIAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEK 2714
S+ + +N K+L K A E D N EEL++Q + D L E +
Sbjct: 1449 AQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ---NKRFDCLKGEMED- 1504
Query: 2715 LCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIK 2774
+K+++E K N E + K Q +I L D + + ++ + L ++
Sbjct: 1505 -----------DKSKME---KKESNLETELKSQTARIMELEDHITQKTIE--IESLNEVL 1548
Query: 2775 KTRDEKIQLSNQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLS---------SELEDEK 2825
K +++ + ++EL+ QK Q+L + + + L+ +ELE +K
Sbjct: 1549 KNYNQQKDIEHKELV---QKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKK 1605
Query: 2826 EEISSPDMCPRPESPVFGASG---QEELAKRLAELE---------LSREFLSALGDDQDW 2873
+E+ ++ + + A + E A +LAEL+ + ++ LS + + ++
Sbjct: 1606 KELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQ 1665
Query: 2874 FDEDFGLSSSHKIQKNKAEETIVPLMAEPKRVTQQPCETLLAVPHTAEEV 2923
+ + S K + E V ++ E + + L VP +A+ V
Sbjct: 1666 YKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNV 1715
Score = 78.6 bits (192), Expect = 9e-14
Identities = 294/1568 (18%), Positives = 622/1568 (39%), Gaps = 245/1568 (15%)
Query: 1339 IEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
++E ++ + ISL Q+ S +++ ++ E +A L+ E+E +++L
Sbjct: 437 MDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQEL 496
Query: 1399 EETRNKAAQVHAESLQQVVQ-SQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAE 1457
+ + E ++ ++ SQ E ++ QE +Q E+ L E E
Sbjct: 497 TKKLQTREREFQEQMKVALEKSQSEYLKISQE------KEQQESLAL---------EELE 541
Query: 1458 LTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTL-D 1516
L + AIL + + + ++ L+ ET R + + L S E +L +
Sbjct: 542 LQKK-------------AILTESENK-----LRDLQQEAETYR-TRILELESSLEKSLQE 582
Query: 1517 SKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQ 1576
+K+Q S D KN + + + + S K + L EK++ + +Q
Sbjct: 583 NKNQ----SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQ-VLKQQ 637
Query: 1577 VQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRF 1636
QT + LR EK++ LK E + + IEE + ++L
Sbjct: 638 YQTEM-EKLRE----KCEQEKETL-------LKDKEIIFQAHIEEMNEKTL--------- 676
Query: 1637 NMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAA 1696
EK + + +S L +L S +D K E+ K +E +
Sbjct: 677 --EKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQEL---EAKMDEQKNH 731
Query: 1697 HQSSL----------LRLREKALKEKTKAELAWLEHQKKHLRD-KGEDDKMPPLRKKQRG 1745
HQ + ++ EKALK++ L+ + KHL++ + + + K+ G
Sbjct: 732 HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEG 791
Query: 1746 LLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEK--LKSAGESKL 1803
LQQ A++ Q A ++ + +E++ +++Q + L+ + L + +++
Sbjct: 792 ---ELQQASAKLDVFQSYQSATHEQTK---AYEEQLAQLQQKLLDLETERILLTKQVAEV 845
Query: 1804 DSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQ----KLKKMRSRMDE--KF 1857
++ D + A DL + S + S+ Q KL+ ++ +
Sbjct: 846 EAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQI 905
Query: 1858 LTKREQKLMQRRQHAEELLE-WKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELED 1916
L ++E ++Q R+ ++ +E ++L A+E I + ++ K K +K++E
Sbjct: 906 LVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYET-------KFKNQEKKMEK 958
Query: 1917 QRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSE--------SIGQEQPGS 1968
+ + KE+ + + L+ E+ + +EL + A+E E + Q
Sbjct: 959 VKQKAKEMQETLKKKL-----LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAG 1013
Query: 1969 PDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHC 2028
++ E +++ES T + L S+ +++ ++ + + ++ +
Sbjct: 1014 ISDAVSRLETNQKEQIESLTEVHRREL-NDVISIWEKKLNQQAEELQEIHEIQLQEKEQE 1072
Query: 2029 YSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQEA 2088
+ + + + E + ++ I LK+E K+ + +N+L+++ K++ A
Sbjct: 1073 VAELKQKILLFGCE----KEEMNKEITWLKEEGVKQDTTLNELQEQLKQK-----SAHVN 1123
Query: 2089 SLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASE--KPKIKPLTPLHRSETA 2146
SL + ++K E +L++ L+ + + Q+ L +E K K+ LT ++ T
Sbjct: 1124 SLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKT-TD 1182
Query: 2147 KNWKSLTES-ERSRGSL-----------ESIAEHVDASLSGSER----------SVSERS 2184
+ ++SL S E+S SL E +A +D +E ++S
Sbjct: 1183 EEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSK 1242
Query: 2185 LSAYAKRVNEWDSRTEDFQ--------TPSPVLRSSRKIREESGD-SLENVPALHLLKEL 2235
+A R++ RT + T S + R++ EE ++ A H L+E
Sbjct: 1243 TNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEE- 1301
Query: 2236 NATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSS 2295
++I M ++ +S + E E + + + A S++ LK L + ++
Sbjct: 1302 -KENQIKSM------KADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINA 1354
Query: 2296 EILSKKDL---PLDSENVQKDLVGLAIE-----NLHKSEEMLKERQSDQDMNHSPNIQSG 2347
L K++L ++ ++ K L L ++ +L + E + + D +
Sbjct: 1355 VTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQV 1414
Query: 2348 KDIHEQKNTKEKDL--------SWSEHLFAPKEIPYSEDFEVSSFKKEISAEL---YKDD 2396
+D+ + +T K+ WS K+ S + + KE+ +L K+
Sbjct: 1415 QDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEA 1474
Query: 2397 FEVSSLLSLRKDSQSCRDK-----PQPMRSSTSGATSFGSNEEISECLSEKSLSIHSNVH 2451
+E ++L K+ ++K M S SN E +E S+ + + H
Sbjct: 1475 YEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLE-TELKSQTARIMELEDH 1533
Query: 2452 -SDRLLELKSPTELMKS-KERSDVEHEQQVTESPSLASVPTADELFDFHIGDRVLIGNVQ 2509
+ + +E++S E++K+ ++ D+EH++ V + + + +++L Q
Sbjct: 1534 ITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQ 1593
Query: 2510 PGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGI------AYFECKEKHGIFAPPQKI 2563
++ + ET + + + E D + E K K QKI
Sbjct: 1594 VYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRK-----AEQKI 1648
Query: 2564 SHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYEKSLPSVNDI 2623
+ I + +++ E+ +E+Y+ + K +E++ + E+ L SV
Sbjct: 1649 AAIKKQL-----LSQMEE--KEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSV--- 1698
Query: 2624 EASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKENKDLISDATEKVSIAAED 2683
E+S + + + NV A +Q DSQ ++ + EK+S+
Sbjct: 1699 ESSQSETLIVPRSAKNV--------AAYTEQEEADSQGCVQKTYE------EKISV---- 1740
Query: 2684 DTLDNTFSEELEKQQQFTEEEDNLYAEASEKLC---TPLLDLLTREKNQLEAQ-LKSSLN 2739
L +E+ + Q+ +E++ + E C L+ L E Q E Q + L
Sbjct: 1741 --LQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQ 1798
Query: 2740 EEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKVTPQ 2799
EE + K + + ++ + K K+ + Q ++ D+ +Q + QE K++T Q
Sbjct: 1799 EELEEKNKKYSL-IVAQHVEKEGGKNNIQAKQNLENVFDD-VQKTLQE------KELTCQ 1850
Query: 2800 DLSQNVEE 2807
L Q ++E
Sbjct: 1851 ILEQKIKE 1858
Score = 73.6 bits (179), Expect = 3e-12
Identities = 217/1075 (20%), Positives = 440/1075 (40%), Gaps = 157/1075 (14%)
Query: 1344 RQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLK-----AEQEALESQ-RQ 1397
R+L+DV + L QQ L +I + Q Q E+++A LK K E+E + +
Sbjct: 1038 RELNDVISIWEKKLNQQAE-ELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITW 1096
Query: 1398 LEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAE 1457
L+E K E +Q+ Q V + Q+ T ++ +L D + + E
Sbjct: 1097 LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDET----KLKAHLEKLEVDLNKSLKE--- 1149
Query: 1458 LTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEG-TLD 1516
T + + +V L +L + ++ + + +L+T TD + S+ S K +L+
Sbjct: 1150 --NTFLQEQLVE----LKMLAEEDKRKVSELTSKLKT---TDEEFQSLKSSHEKSNKSLE 1200
Query: 1517 SKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKEN---EKKLNGEKIESSI 1573
K ++ + + + + E ++ S K N + + + + +
Sbjct: 1201 DKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKV 1260
Query: 1574 DEQ--VQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRSLLPSE 1631
E ++T L + + L +E+++ +I+ + + + E E + +S ++ + S
Sbjct: 1261 KEALLIKTCTVSELEAQ-LRQLTEEQNTLNISFQQAT---HQLEEKENQIKSMKADIESL 1316
Query: 1632 SHRRFNMEKRRGHHDDSDEEASPEKTTLSTA--KELNMPFSGGQDSFSKFTMEMVRQYMK 1689
+ ++K G+ ++A+ EK + T KEL+ + + ++++ +K
Sbjct: 1317 VTEKEALQKEGGNQ----QQAASEKESCITQLKKELSENINA---------VTLMKEELK 1363
Query: 1690 EEEMRAAHQSSLL-----RLREKALKEKTKAELAWLEHQ----KKHLRDKGED--DKMPP 1738
E+++ + S L +L+ + +A ++ L Q K L D+ +D K+
Sbjct: 1364 EKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDT 1423
Query: 1739 LRKKQRGLLLRLQ---------QEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTI 1789
L K++ L ++ ++KA+ + Q N + QL LK +E EK Q +
Sbjct: 1424 LSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINL 1483
Query: 1790 KLQEKLKSAGESKLD----SHSDDDTKDNKATSPGPTDLETRSP------SPISISSSET 1839
L+E+L + + D DD +K K S T+L++++ I+ + E
Sbjct: 1484 -LKEELDQQNK-RFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEI 1541
Query: 1840 SSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWK-RRLDAEEAEIRQMEKQALA 1898
S+ + LK + D + ++L+Q+ QH +EL E K R+ E +I +E Q +
Sbjct: 1542 ESLNEVLKNYNQQKDIE-----HKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYS 1596
Query: 1899 AWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIP-EELGSPAVEYVP 1957
EL +T KKELE K S+EE L L SES+ EL A + +
Sbjct: 1597 M-KAEL---ETKKKELEHVNLSVK---SKEEELKALEDRLESESAAKLAELKRKAEQKIA 1649
Query: 1958 S----------ESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQES 2007
+ E Q + G+ H L+E QE E H L + SV +S
Sbjct: 1650 AIKKQLLSQMEEKEEQYKKGTESH--LSELNTKLQEREREV----HILEEKLKSVESSQS 1703
Query: 2008 SKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSV 2067
+ + +S ++ +++++ + +Q Q E +I L+ L +++ +
Sbjct: 1704 ---------ETLIVPRSAKNVAAYTEQEEADSQGCV---QKTYEEKISVLQRNLTEKEKL 1751
Query: 2068 VNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSS 2127
+ ++ +E+++ + + + + IK AE Q + S Q
Sbjct: 1752 LQRVGQEKEETVSSHFEMR-------CQYQERLIKLEHAEAKQHEDQSMIGHLQ----EE 1800
Query: 2128 ASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSA 2187
EK K L E ++ +++ +LE++ + V +L E +
Sbjct: 1801 LEEKNKKYSLIVAQHVEKEGGKNNI----QAKQNLENVFDDVQKTLQEKELTCQ-----I 1851
Query: 2188 YAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDG 2247
+++ E DS ++R R E + L L++++ ++ ++ +
Sbjct: 1852 LEQKIKELDSC---------LVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEE 1902
Query: 2248 KVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSKKDLPLDS 2307
E SK ++ + ++ + F G KL E + +KDL +
Sbjct: 1903 NTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEI-----VRLQKDLRMLR 1957
Query: 2308 ENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNI-QSGKDIHEQKNTKEKDL 2361
+ Q++L L E + EE +K+ Q D ++ H+ + Q ++ + Q KE++L
Sbjct: 1958 KEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL 2012
Score = 70.5 bits (171), Expect = 2e-11
Identities = 272/1404 (19%), Positives = 553/1404 (39%), Gaps = 161/1404 (11%)
Query: 1490 KQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSES--SGYKNHDRRSSSGSS 1547
K+L+ + +++ +L+ ++ + S + + S++E G N + + +
Sbjct: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
Query: 1548 RQESPSVPSCKENEKKLNGEKI--ESSIDEQVQTAADDSLR---------SDSVPSLPDE 1596
++ VPS + + E + SS + V+T++ +SL S PS D
Sbjct: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS 122
Query: 1597 KDSTSIATEYSLKFDESMTEDEIEEQSFRSLLPSES-----HRRFNMEKRRGHHDDSDEE 1651
+ + SL ++ + E+S S S ++ EK++ S +
Sbjct: 123 EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQ 182
Query: 1652 ASPEKTTLSTAKELNMPFSGGQDSFSKF--TMEMVRQYMKEEEMRAAHQSSLL--RLREK 1707
+ +EL M + +F ++E QY+ + Q SLL RLR
Sbjct: 183 DKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQT----QVSLLKQRLRNG 238
Query: 1708 ALKEKTKAELAWLEHQKKHL--RDKGEDDKMPPLR-----KKQRGLLLRLQQEKAEIKRL 1760
+ L LE Q + + E D P + K L R+++++ +KR
Sbjct: 239 PMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRC 298
Query: 1761 QEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPG 1820
+E ++ +++ L+ ++E +++ ++ EK+K D H + TK
Sbjct: 299 KETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK-------DLHMAEKTKLITQLRDA 351
Query: 1821 PTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKR 1880
+E + +ET M + +M+ E+ + + ++ Q EEL E K
Sbjct: 352 KNLIEQLEQDK-GMVIAETKRQMHETLEMK----EEEIAQLRSRIKQMTTQGEELREQKE 406
Query: 1881 RLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNS 1940
+ +E A ++EK A E + K K E+ D++ + E SEEE
Sbjct: 407 K--SERAAFEELEKALSTAQKTEEARRKL-KAEM-DEQIKTIEKTSEEE----------- 451
Query: 1941 ESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQEL-ESSTSPSKHSLPKSC 1999
S+ +EL E V E E++ Q+L E + + L K
Sbjct: 452 RISLQQELSRVKQEVVDVMKKSSE-----------EQIAKLQKLHEKELARKEQELTKKL 500
Query: 2000 TSVSK--QESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQ--SDIEGRIR 2055
+ + QE K + +L I + ESL++ + E ++ E ++R
Sbjct: 501 QTREREFQEQMKVALEKSQSEYLKISQEKE----QQESLALEELELQKKAILTESENKLR 556
Query: 2056 ALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETS 2115
L+ E ++ + +L+ +K +E K Q L LE+ K E++ +E
Sbjct: 557 DLQQEAETYRTRILELESSLEKSLQEN-KNQSKDLAVHLEAEK---NKHNKEITVMVEKH 612
Query: 2116 PTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSG 2175
T +K A K++ L +++E K E+ E++ + +
Sbjct: 613 KTELESLKHQQDALWTEKLQVLKQQYQTEMEK------LREKCEQEKETLLKDKEIIFQA 666
Query: 2176 SERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKEL 2235
++E++L + E +S + + S VL++ K+ EE L +LK+
Sbjct: 667 HIEEMNEKTLEKLDVKQTELESLSSEL---SEVLKARHKLEEE----------LSVLKD- 712
Query: 2236 NATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVL--LKLVLEQGD 2293
T ++ + K+ E +K+ ++ + +K+ ++ +++ D + L+L+L++ D
Sbjct: 713 -QTDKMKQELEAKMDE--QKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERD 769
Query: 2294 SSEILSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQ 2353
K+ EN++ D+ E L ++ L QS Q H ++ ++ Q
Sbjct: 770 K----HLKEHQAHVENLEADIKRSEGE-LQQASAKLDVFQSYQSATHE-QTKAYEEQLAQ 823
Query: 2354 KNTKEKDLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVSSLL-SLRKDSQSC 2412
K DL +E + K++ EV + KK++ EL +V L+ L K +
Sbjct: 824 LQQKLLDLE-TERILLTKQVA-----EVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877
Query: 2413 RDKPQPMRSSTSGATSFGS--NEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKER 2470
K + + G+ E+ + L EK I + + E++ T+ + +KE
Sbjct: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMI-LQMREGQKKEIEILTQKLSAKED 936
Query: 2471 S----DVEHEQQV-TESPSLASVPTADELFDFHIGDRVL--IGNVQPGILRFKGETSFAK 2523
S + E+E + + + V + + ++L ++ + E S +
Sbjct: 937 SIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKE 996
Query: 2524 GFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHI-PENFDDYVDINEDEDC 2582
+ L+ + N+ G D ++ E +K I + ++ + +D + I E +
Sbjct: 997 KQFNAKMLEMAQANSAGISDAVSRLETNQKEQI----ESLTEVHRRELNDVISIWEKKLN 1052
Query: 2583 YSDERYQCYNQEQNDTEGPKDREKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNVQD 2642
E Q ++ Q +++E++V+E +K L + E LK E
Sbjct: 1053 QQAEELQEIHEIQ-----LQEKEQEVAE-LKQKILLFGCEKEEMNKEITWLKEEGVKQDT 1106
Query: 2643 ISGVLEAHVHQQSSVDSQISSKENKDLISDATEKVSIAAEDDTLDNTF-SEELEKQQQFT 2701
L+ + Q+S+ + ++ E K + EK+ + +NTF E+L + +
Sbjct: 1107 TLNELQEQLKQKSAHVNSLAQDETK--LKAHLEKLEVDLNKSLKENTFLQEQLVELKMLA 1164
Query: 2702 EEEDNLYAEASEKLCT---PLLDLLTREKNQLEAQLKSSLNEEKKSKQ---QLEKISLLT 2755
EE+ +E + KL T L + + ++ SL +K S++ QL+ T
Sbjct: 1165 EEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKT 1224
Query: 2756 DSLLKVFVKDTVN--------QLQQIKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNVEE 2807
++LL+ + +N L +I + ++ L+ L Q EE
Sbjct: 1225 EALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
Query: 2808 QSP-SISGCFLSSELEDEKEEISS 2830
Q+ +IS + +LE+++ +I S
Sbjct: 1285 QNTLNISFQQATHQLEEKENQIKS 1308
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 100 bits (250), Expect = 2e-20
Identities = 83/311 (26%), Positives = 147/311 (47%), Gaps = 30/311 (9%)
Query: 2480 TESPSLASVPTADELF----DFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPE 2535
T S S++++ A + + IGDRVL+G + G++RF GET FAKG W GVELD+P
Sbjct: 191 TASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGEWCGVELDEPL 250
Query: 2536 GNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQ 2595
G N+G G YF+C+ K+G+FAP K++ I + + +
Sbjct: 251 GKNDGAVAGTRYFQCQPKYGLFAPVHKVT----------KIGFPSTTPAKAKANAVRRVM 300
Query: 2596 NDTEGPKDREKDVSEYFYEKSLPSVNDIEASVNRSRS---LKIETDN--VQDISG---VL 2647
T R S SL S++ + +SV+ S L ET + + ISG +
Sbjct: 301 ATTSASLKRSPSAS------SLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQ 354
Query: 2648 EAHVHQQSSVDSQISSKE-NKDLISDATEKVSIAAEDDTLDNTFSEELEKQQQFTEEEDN 2706
EA +Q ++ ++ ++ + ++ AT V ++ L ++ + + ++
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLR 414
Query: 2707 LYAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDT 2766
EA+++ LL+ L EK ++E L+ + EE +K LE ++ S + KD
Sbjct: 415 TMVEAADREKVELLNQLEEEKRKVE-DLQFRVEEESITKGDLEVATVSEKSRIMELEKDL 473
Query: 2767 VNQLQQIKKTR 2777
++Q++ + R
Sbjct: 474 ALRVQEVAELR 484
Score = 82.4 bits (202), Expect = 6e-15
Identities = 43/117 (36%), Positives = 66/117 (56%), Gaps = 10/117 (8%)
Query: 2458 LKSPTELMKSKERS---------DVEHEQQVTESPSLASVPTADELFD-FHIGDRVLIGN 2507
LK+PT+++K + VE ++ S S T +E D F +G+RV +
Sbjct: 9 LKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRVGERVWVNG 68
Query: 2508 VQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKIS 2564
+PG ++F GET FA G WAG+ LD+P G N+G+ G+ YF+C+ GIF P K++
Sbjct: 69 NKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTRPSKLT 125
Score = 79.7 bits (195), Expect = 4e-14
Identities = 257/1295 (19%), Positives = 504/1295 (38%), Gaps = 156/1295 (12%)
Query: 1118 TSTEKKSTLEPHSTLSPQEDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSSTSSKGKKG 1177
TST + P ST S ++ +A +PS+ S + A + S+ S S KKG
Sbjct: 151 TSTASMVSSSP-STPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSI-KKG 208
Query: 1178 KKEKTEWLDSFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTDSTLEDLS 1237
++E + +R G K+G L DF + L++
Sbjct: 209 EREL------------------KIGDRVLVGGTKAGVVRFLGETDFAKGEWCGVELDEPL 250
Query: 1238 GHSVSVSSDKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSS----VMPPTITGFKPN 1293
G + + Q P L K + T+ ++K++ VM T K +
Sbjct: 251 GKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVMATTSASLKRS 310
Query: 1294 APLTDLNPAASRTTTENMAPIPGSKRFSPAGL----HHRMAAELSYLNAIEESVRQLSD- 1348
P+AS ++ + S R S GL R A ++S A++E++++
Sbjct: 311 -------PSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQH 363
Query: 1349 VERVRGISLAQQESVSLAQIIKAQQQ--RHERDLALLKLKAEQEALESQRQLEETRNK-- 1404
+E+ L + + A++ KA E++LAL + +Q LE + ++++ R
Sbjct: 364 IEQ-----LLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVE 418
Query: 1405 -AAQVHAESLQQVVQSQREVTE----VLQEATCK------IAAQQSETARLTTDAARQIC 1453
A + E L Q+ + +R+V + V +E+ K +++S L D A ++
Sbjct: 419 AADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQ 478
Query: 1454 EMAELTRTHISDAVVAS-GAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKE 1512
E+AEL R S+ L++L + + L+ + E R ++ KE
Sbjct: 479 EVAELRRRLESNKPAGDVDMSLSLLQE---------ISSLQEKLEVTRTDHQREITSLKE 529
Query: 1513 --GTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIE 1570
G + HQK + + +E +N +S + +E+ V + ++ K+E
Sbjct: 530 HFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKS-------KLE 582
Query: 1571 SSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRSLLPS 1630
++I Q A + L+ L E T+ E + ++ + + E ++ ++ S
Sbjct: 583 TAIASHQQ--AMEELKVSFSKGLGTE---TAEFAELKTQIEKMRLDYQHEIENLQNQQDS 637
Query: 1631 E--SHRRFNMEKRRGHHDD--SDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMVRQ 1686
E +H + ME R ++E S E K + +D+ +K ++
Sbjct: 638 ERAAHAK-EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK- 695
Query: 1687 YMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGL 1746
+KE E+ A + ++ + + E L+ LR + K + +Q+
Sbjct: 696 -VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA--LRKASSEGKSEMKKLRQQLE 752
Query: 1747 LLRLQQEKAEIKRLQEANKAARKERQL------ILKQQEEIEKIRQTTIKLQEKLKSAGE 1800
Q + EI++ E++KA+ R+L + QE + ++ Q L+++L+ E
Sbjct: 753 AAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE 812
Query: 1801 SKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTK 1860
K S++ ++ L + +SS ++KL++ + M+ KF K
Sbjct: 813 -KFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSD-----LEKLRENLADMEAKFREK 866
Query: 1861 REQKLMQRRQHAEELLEWKRRLDAEEAEIRQM---EKQALAAWDKELIKPKTPKKELEDQ 1917
E++ E+L++ K +L+ + AEI +M L + EL + +EL+ +
Sbjct: 867 DERE--------EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLK 918
Query: 1918 RTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSES--IGQEQPGSPDHSILT 1975
T+ E AS + + + + +E S E E E E+ H+
Sbjct: 919 LTKANENASFLQKSIEDMT-VKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHN-QC 976
Query: 1976 EEMICSQELESSTSPSKH-----SLPKSCTSVSKQESSKGSHRTGGQC-----HLPIKSH 2025
+E+ E +S + +KH +L K T + ++ KG+ L ++
Sbjct: 977 QELKARYERATSETKTKHEEILQNLQK--TLLDTEDKLKGAREENSGLLQELEELRKQAD 1034
Query: 2026 QHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKA 2085
+ + + E + T ++++ + K K ++ ++ LK+ K +E K+
Sbjct: 1035 KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKS 1094
Query: 2086 QEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSET 2145
+E ++ + +EF K ++ET A Q SA ++ +K L RS
Sbjct: 1095 KELLTVEN-QKMEEFRK--------EIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1145
Query: 2146 AKNWKSLTESERS--RGSLESIAEHVDASL--SGSERSVSERSLSAYAKRVNEWDSRTED 2201
E ERS L + + + + E++ ++S+S + + E D+ E
Sbjct: 1146 EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEK 1205
Query: 2202 FQTPSPVLR---SSRKIREESGDSLEN------VPALHLLKELNATSRILDMSDGKVGES 2252
+ VLR +S K +LE+ + +L +L R L S G
Sbjct: 1206 LRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQ 1265
Query: 2253 SKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLE-----QGDSSEILSKKDLPLDS 2307
+ + E + S I D K + ++++ E GD D S
Sbjct: 1266 ADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQS 1325
Query: 2308 ENVQKDLVGLA-IENLHKSEEMLKERQSDQDMNHS 2341
+ + + +LH +E+ + Q +D HS
Sbjct: 1326 KKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHS 1360
Score = 57.0 bits (136), Expect = 3e-07
Identities = 224/1132 (19%), Positives = 414/1132 (36%), Gaps = 163/1132 (14%)
Query: 1827 RSPSPISISS--SETSSIMQK------LKKMRSRMDEKF--LTKREQKLMQRRQHAEELL 1876
RSPS S+SS S SS+ + L + SR K T ++ L +++QH E+LL
Sbjct: 309 RSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLL 368
Query: 1877 EWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKK----ELE---DQRTEQKEIASEEE 1929
+ D E AE+ + + ++EL + ELE DQ E A E+
Sbjct: 369 AER---DLERAEVAKATSH-VGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK 424
Query: 1930 SPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTS 1989
V L + L E E+L + EE I +LE +T
Sbjct: 425 --VELLNQLEEEKRKVEDL----------------------QFRVEEESITKGDLEVATV 460
Query: 1990 PSKH-------SLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMT--- 2039
K L V++ S++ G + + Q S E L +T
Sbjct: 461 SEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQ-EKLEVTRTD 519
Query: 2040 -QSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQK----------KRQKERLKAQEA 2088
Q E TS + R + E++ + +L KE + K + + ++
Sbjct: 520 HQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKS 579
Query: 2089 SLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKT------LSSASEKPKIKPLTPLHR 2142
L + S+ + +++ + S+ L T ++KT L E ++ R
Sbjct: 580 KLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSER 639
Query: 2143 SETAKNWKSLTES-----ERSRGSLESIAEHVDASLSG------------SERSVSERSL 2185
+ AK ++L + SLE+I +D + E + + L
Sbjct: 640 AAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKEL 699
Query: 2186 SAYAKRVNEW----DSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRI 2241
+ NE D+ T + L +R+ S + + L E A +I
Sbjct: 700 EVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEA-AEKQI 758
Query: 2242 LDMSDGKVGESSKKSEI-KEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSK 2300
+ K ESSK S I +E++ +LK + +++ S+ + +K LE+ +IL +
Sbjct: 759 KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ----VKETLEK--ELQILKE 812
Query: 2301 KDLPLDSE--NVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKE 2358
K E +VQ+ + + LH+ EE SD + N+ + +K+ +E
Sbjct: 813 KFAEASEEAVSVQRSMQE-TVNKLHQKEEQFNMLSSDLEKLRE-NLADMEAKFREKDERE 870
Query: 2359 KDLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQP 2418
E L KE ++ E+ + S++L K + E LR + +
Sbjct: 871 ------EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDE------LRLKERDVEELQLK 918
Query: 2419 MRSSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQ 2478
+ + A+ + E +E+S + H + EL+ ++ K + Q+
Sbjct: 919 LTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQE 978
Query: 2479 VTESPSLASVPTADELFDFHIGDRVLIGNVQPGIL----RFKGETSFAKGFWAGVE---- 2530
+ A+ T + ++ N+Q +L + KG G +E
Sbjct: 979 LKARYERATSETKTK-------HEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK 1031
Query: 2531 -LDKPEGNNNGTYDGIAYFE--CKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDER 2587
DK + D + E KEK A + + +D ++ + + E
Sbjct: 1032 QADKAKAAQTAE-DAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE 1090
Query: 2588 YQCYNQEQNDTEGPKDRE--KDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNVQDISG 2645
++E E K E K++ E + + + A + L E +D
Sbjct: 1091 LN-KSKELLTVENQKMEEFRKEI-ETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVT 1148
Query: 2646 VLEAHVHQQSSVDSQI--SSKENKDLISDATE-KVSIAAEDDTLDNTFSEELEKQQQFTE 2702
+ ++S +++Q+ K I DA E K S+ +E+ + ++
Sbjct: 1149 SHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRN 1208
Query: 2703 EEDNLYAE-ASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKV 2761
E L E AS K ++ L +K +LE ++K+ + K++K+QL S TD+
Sbjct: 1209 EVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADE 1268
Query: 2762 ----------FVKDTVNQLQQIKKTRDEKIQLSNQELL---GDDQKKVTPQDLSQNVEEQ 2808
F+ + LQ+ + K+++ ++ L GDD D + +++
Sbjct: 1269 DERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKK 1328
Query: 2809 SP---SISGCFLSSELEDEKEEISSPDMCPRPESPVFGASGQEELAKRLAEL 2857
I CF + ED + + P S G+ G+E + E+
Sbjct: 1329 PRLFCDICDCFDLHDTEDCPTQAQMSE--DPPHSTHHGSRGEERPYCEICEM 1378
Score = 52.8 bits (125), Expect = 5e-06
Identities = 161/839 (19%), Positives = 326/839 (38%), Gaps = 132/839 (15%)
Query: 1684 VRQYMKEEEMRAAHQSSLLRLR--EKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRK 1741
+++ +KE++ H LL R E+A K + + +E + RD G D +
Sbjct: 353 LQEALKEKQQ---HIEQLLAERDLERAEVAKATSHVGEIEQELALARD-GHDQHV----- 403
Query: 1742 KQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGES 1801
L L+ + +++ + EA A R++ +L+ + +EE K+ +++E+ + G+
Sbjct: 404 ------LELEAKMDQLRTMVEA--ADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDL 455
Query: 1802 KLDSHSDDDT-----KDNKATSPGPTDLETRSPSPISISSSETS-SIMQKLKKMRSRMDE 1855
++ + S+ KD +L R S + S S++Q++ ++ +++
Sbjct: 456 EVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLE- 514
Query: 1856 KFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELE 1915
+ R H E+ K A E +T +KE++
Sbjct: 515 ----------VTRTDHQREITSLKEHFGARE---------------------ETHQKEIK 543
Query: 1916 DQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVE-YVPSESIGQEQPGSPDHSIL 1974
T ++++ E ES H N E+S L +E + S E+ L
Sbjct: 544 ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL 603
Query: 1975 TEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDE 2034
E EL++ + ++ Q+ S+ + +H
Sbjct: 604 GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERA------------AHAKEMEALRA 651
Query: 2035 SLSMTQSETTSDQSDIEGRIRALKDE-LRKRKSVVNQLKK-EQKKRQKERLKAQEASLIK 2092
L E + I ++ +D+ L + + +N+L++ E K ++ E L+A+ K
Sbjct: 652 KLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK 711
Query: 2093 QLESYDEFIKKTEAELSQDLE----TSPTAKPQIKTLSSASE--KPKIKPLTPLHRSETA 2146
++++ +K TE +L DL+ S K ++K L E + +IK L +E++
Sbjct: 712 VIDNFTSQLKATEEKL-LDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESS 770
Query: 2147 K----------NWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYA------K 2190
K LT + + + + E ++ L + +E S A + +
Sbjct: 771 KASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE 830
Query: 2191 RVNEWDSRTEDFQTPSPVLRSSR--------KIREESGDSLENVPALHLLKELNATSRIL 2242
VN+ + E F S L R K RE+ + + A L+ N + I+
Sbjct: 831 TVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLE--NDIAEIM 888
Query: 2243 DMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSK-- 2300
MS + +K + + +LK+ +E ++ LKL + +++ L K
Sbjct: 889 KMSGDNSSQLTKMN-----DELRLKERDVE---------ELQLKLT-KANENASFLQKSI 933
Query: 2301 KDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKD 2360
+D+ + +E Q++ E + E L + + + +H+ Q K +E+ ++ K
Sbjct: 934 EDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHN-QCQELKARYERATSETK- 991
Query: 2361 LSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMR 2420
+ E + + + + +E ++ L ++ E+ K +Q+ D Q M
Sbjct: 992 -TKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIME 1050
Query: 2421 SSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLE--LKSPTELMKSKERSDVEHEQ 2477
T T E ++ K + D L E LK+ EL KSKE VE+++
Sbjct: 1051 QMTKEKT-----ETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQK 1104
Score = 52.4 bits (124), Expect = 7e-06
Identities = 146/826 (17%), Positives = 317/826 (38%), Gaps = 115/826 (13%)
Query: 1686 QYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRG 1745
Q+ EEE + + EK+ + + +LA + LR + E +K
Sbjct: 442 QFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLS 501
Query: 1746 LLLRLQ--QEKAEIKRLQEANKAARKERQLILKQ---QEEIEKIRQTTIKLQEKLKSAGE 1800
LL + QEK E+ R + + ++ Q+EI+ + T KL ++ +S +
Sbjct: 502 LLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESL-K 560
Query: 1801 SKLDSHSDDDTKDNKAT------------SPGPTDLETRSPSPISISSSETSSIMQKLKK 1848
SKL+ H++ + D A +L+ + ++E + + +++K
Sbjct: 561 SKLE-HANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEK 619
Query: 1849 MRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRL----DAEEAEIRQMEKQALAAWDKEL 1904
MR + + Q+ +R HA+E+ + +L +E + + + A D+ L
Sbjct: 620 MRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHL 679
Query: 1905 IKPKTPKKELEDQRTEQKEIA---SEEESPVPLYSHLNSESSIPEE--LGSPAVEYVPSE 1959
++ + +L++ + KE+ ++ + + S+ EE L A+ SE
Sbjct: 680 VEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSE 739
Query: 1960 SIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCH 2019
E E+ I E+E + SK S S++++ + T Q +
Sbjct: 740 G-KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS------SITRELQGRELKLTNLQEN 792
Query: 2020 LP-IKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKR 2078
L + + + L +E + + ++ ++ ++L +++ N L + +K
Sbjct: 793 LSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKL 852
Query: 2079 QKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLT 2138
+E L EA ++ E ++ IK E +L D+ A+ + ++S+ K+
Sbjct: 853 -RENLADMEAKFREKDEREEQLIKAKE-KLENDI-----AEIMKMSGDNSSQLTKMNDEL 905
Query: 2139 PLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVS---ERSLSAYAKRVNEW 2195
L + + LT++ + L+ E + S++ + E +++++
Sbjct: 906 RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 965
Query: 2196 DSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKK 2255
+ + E L K R E S +L+ L T +LD D G +
Sbjct: 966 EKKMETSHNQCQEL----KARYERATSETKTKHEEILQNLQKT--LLDTEDKLKGAREEN 1019
Query: 2256 SEI-KEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDL 2314
S + +E+E + + K + A + E ++ ++ E+ ++ + S +D + +Q +L
Sbjct: 1020 SGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTET--LASLEDTKQTNAKLQNEL 1077
Query: 2315 VGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIP 2374
L KE +L E L KE+
Sbjct: 1078 DTL---------------------------------------KENNLKNVEELNKSKELL 1098
Query: 2375 YSEDFEVSSFKKEIS-------------AELYKDDFEVSSLLSLRKDSQSCRDKPQPMRS 2421
E+ ++ F+KEI + L +++ +++ L +D + K + RS
Sbjct: 1099 TVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERS 1158
Query: 2422 STSG--------ATSFGSNEEISECLSEKSLSIHSNVHSDRLLELK 2459
+ + F + + + +KS+SI S + +++ EL+
Sbjct: 1159 VLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1204
Score = 49.7 bits (117), Expect = 5e-05
Identities = 172/871 (19%), Positives = 336/871 (38%), Gaps = 100/871 (11%)
Query: 2131 KPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAK 2190
+PK P+H+ T + S T ++ ++ + ASL S + S S+S+ A
Sbjct: 266 QPKYGLFAPVHKV-TKIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVAS 324
Query: 2191 RVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKVG 2250
V+ SRT S SR R+ SG + + + D+ +V
Sbjct: 325 SVSSRPSRTGLLTETS-----SRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVA 379
Query: 2251 ESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSKKDLPLDSENV 2310
+++ E E + + E K D L +V E D ++ L + V
Sbjct: 380 KATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMV-EAADREKVELLNQLEEEKRKV 438
Query: 2311 QKDLVGLAIENLHKSE---------EMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDL 2361
+ + E++ K + + E + D + + + + K + D+
Sbjct: 439 EDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDM 498
Query: 2362 SWS-----EHLFAPKEIPYSE-DFEVSSFKKEISAELYKDDFEVSSLLS----LRKDSQS 2411
S S L E+ ++ E++S K+ A E+ +L + L K+++S
Sbjct: 499 SLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENES 558
Query: 2412 CRDKPQPMRSSTSGA---------TSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPT 2462
+ K + S T+ S+++ E L + S S + ELK+
Sbjct: 559 LKSKLEHANKENSDVIALWKSKLETAIASHQQAMEEL-KVSFSKGLGTETAEFAELKTQI 617
Query: 2463 ELMKSKERSDVEHEQQVTESPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETSFA 2522
E M+ + ++E+ Q +S A A E+ +I + + + + A
Sbjct: 618 EKMRLDYQHEIENLQNQQDSERAAH---AKEMEALRAKLMKVIKEKENSLEAIRSKLDKA 674
Query: 2523 KGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDC 2582
+ L + E N + A + KE + A + + + +NF + E++
Sbjct: 675 ED----QHLVEMEDTLNKLQE--AEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLL 728
Query: 2583 YSDERYQCYNQEQNDTEGPKDR----EKDVSEYFYEKSLPSVNDIEASVNRS---RSLKI 2635
D + ++ +++ + + + EK + EK+ S +S+ R R LK+
Sbjct: 729 DLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSK--ASSITRELQGRELKL 786
Query: 2636 ETDNVQDISGVLEAHVHQQSSVDSQISSKENKDLISDATEKVSIAAEDD-TLDNTFSEEL 2694
++ + S SQ+ K+L EK + A+E+ ++ + E +
Sbjct: 787 -------------TNLQENLSEVSQVKETLEKEL-QILKEKFAEASEEAVSVQRSMQETV 832
Query: 2695 EKQQQFTEEEDNLYAEASEKLCTPLLDLLT--REKNQLEAQLKSSLNEEKKSKQQLEKI- 2751
K Q EE+ N+ + EKL L D+ REK++ E QL + + + ++ K+
Sbjct: 833 NKLHQ-KEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMS 891
Query: 2752 ----SLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKV--TPQDLSQNV 2805
S LT ++ +K+ + Q+K T+ + Q+ + D K + Q+ ++
Sbjct: 892 GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH 951
Query: 2806 EEQSPSISGCFLSSELED-EKEEISSPDMCPRPESPVFGASGQEELAKRLAELELSREFL 2864
EE+ L +L D EK+ +S + C ++ A+ + + L + L
Sbjct: 952 EEEKKE-----LERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLL 1006
Query: 2865 SALGDDQDWFDEDFGLSSS-----HKIQKNKAEETIVPLMAEPKRVTQQPCETLLAVPHT 2919
+ +E+ GL + K KA +T M +++T++ ETL ++ T
Sbjct: 1007 DTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDT 1066
Query: 2920 AE-------EVEILVHN---AAEELWKWKEL 2940
+ E++ L N EEL K KEL
Sbjct: 1067 KQTNAKLQNELDTLKENNLKNVEELNKSKEL 1097
Score = 32.0 bits (71), Expect = 9.8
Identities = 47/217 (21%), Positives = 89/217 (41%), Gaps = 39/217 (17%)
Query: 471 AESDPRLDVLHRHLQRNSERSRSKSRSEN----NIKKLASSLPD--------NKQEENTA 518
AE+ + R +Q + K N +++KL +L D +++EE
Sbjct: 815 AEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLI 874
Query: 519 LNKDFLPIEIRGILDDLQLDSTAHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKIT- 577
K+ L +I I+ +S+ T D + L+ + V+ K+T
Sbjct: 875 KAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERD-------------VEELQLKLTK 921
Query: 578 ANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQELYRKQK 637
ANE+ + K T + Q Q+E +K EEKK + ++L +L +K +
Sbjct: 922 ANENASFLQKSIEDMTVKAEQ----SQQEAAKKHEEEKK-------ELERKLSDLEKKME 970
Query: 638 EAFTKVKNVPPSEPSATRRLQETYSKLL--LEKTLLE 672
+ + + + AT + + ++L L+KTLL+
Sbjct: 971 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD 1007
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 99.0 bits (245), Expect = 7e-20
Identities = 91/340 (26%), Positives = 161/340 (47%), Gaps = 40/340 (11%)
Query: 2480 TESPSLASVPTADELF----DFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPE 2535
T S S++++ A + + IGDRVL+G + G++RF GET FAKG W GVELD+P
Sbjct: 191 TASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGEWCGVELDEPL 250
Query: 2536 GNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQ 2595
G N+G G YF+C+ K+G+FAP K++ I + + +
Sbjct: 251 GKNDGAVAGTRYFQCQPKYGLFAPVHKVT----------KIGFPSTTPAKAKANAVRRVM 300
Query: 2596 NDTEGPKDREKDVSEYFYEKSLPSVNDIEASVNRSRS---LKIETDN--VQDISG---VL 2647
T R S SL S++ + +SV+ S L ET + + ISG +
Sbjct: 301 ATTSASLKRSPSAS------SLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQ 354
Query: 2648 EAHVHQQSSVDSQISSKE-NKDLISDATEKVSIAAEDDTLDNTFSEELEKQQQFTEEEDN 2706
EA +Q ++ ++ ++ + ++ AT V ++ L ++ + + ++
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLR 414
Query: 2707 LYAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDT 2766
EA+++ LL+ L EK ++E L+ + EE +K LE + L + +K
Sbjct: 415 TMVEAADREKVELLNQLEEEKRKVE-DLQFRVEEESITKGDLETQTKLEHARIK-----E 468
Query: 2767 VNQLQQIKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNVE 2806
+ Q +KT+ +K+Q +EL +D + T + S+ +E
Sbjct: 469 LEQSLLFEKTKADKLQ---REL--EDTRVATVSEKSRIME 503
Score = 82.4 bits (202), Expect = 6e-15
Identities = 43/117 (36%), Positives = 66/117 (56%), Gaps = 10/117 (8%)
Query: 2458 LKSPTELMKSKERS---------DVEHEQQVTESPSLASVPTADELFD-FHIGDRVLIGN 2507
LK+PT+++K + VE ++ S S T +E D F +G+RV +
Sbjct: 9 LKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRVGERVWVNG 68
Query: 2508 VQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKIS 2564
+PG ++F GET FA G WAG+ LD+P G N+G+ G+ YF+C+ GIF P K++
Sbjct: 69 NKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTRPSKLT 125
Score = 78.6 bits (192), Expect = 9e-14
Identities = 145/736 (19%), Positives = 295/736 (40%), Gaps = 91/736 (12%)
Query: 1379 DLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQ 1438
+ A LK + E+ L+ Q ++E +N+ A +++ + ++ +V++E + A +
Sbjct: 644 EFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIR 703
Query: 1439 SETARLTTDAARQICEMAE-LTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTE 1497
S +L + + EM + L + ++ V L + Q + + +F QL+ TE
Sbjct: 704 S---KLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA-TE 759
Query: 1498 TDRKSPSVSLSQSKEGTLDSK--HQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVP 1555
S EG + K Q+ A+ KN + +S +R+
Sbjct: 760 EKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRE------ 813
Query: 1556 SCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMT 1615
+ E KL + S QV+ + L+ K+ + A+E ++ SM
Sbjct: 814 -LQGRELKLTNLQENLSEVSQVKETLEKELQI--------LKEKFAEASEEAVSVQRSMQ 864
Query: 1616 ED----EIEEQSFRSLLPSESHRRFN---MEKRRGHHDDSDEEASPEKTTLSTAKELNMP 1668
E +E+ F L R N ME + D+ +E+ K L M
Sbjct: 865 ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMK 924
Query: 1669 FSGGQDSFSKFT-----MEMVRQYMKEEEMRAAHQSSLLRLREKALKEKT-KAELAWLEH 1722
SG D+ S+ T + + + ++E +++ + +K++++ T KAE + E
Sbjct: 925 MSG--DNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEA 982
Query: 1723 QKKHLRDKGE-DDKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEI 1781
KKH +K E + K+ L KK + Q+ KA +R K K +E +
Sbjct: 983 AKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKT---------KHEEIL 1033
Query: 1782 EKIRQTTIKLQEKLKSAGESK---LDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSE 1838
+ +++T + ++KLK A E L + + +KA + + + ++ +E
Sbjct: 1034 QNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTE 1093
Query: 1839 TSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALA 1898
T + ++ K+ +++ + T +E L ++ EEL + K L E ++ + K+
Sbjct: 1094 TLASLEDTKQTNAKLQNELDTLKENNL----KNVEELNKSKELLTVENQKMEEFRKEIET 1149
Query: 1899 AWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPS 1958
K+ Q+++Q EE + EELG E
Sbjct: 1150 L------------KQAAAQKSQQLSALQEENV------------KLAEELGRSRDEVTSH 1185
Query: 1959 ESIGQEQPGSPDHSILTEEMICSQELESS----TSPSKHSLPKSCTSVSKQESSKGSHRT 2014
+ + +E+ S+L +++ ++ ES K SL KS + S + K +
Sbjct: 1186 QKLEEER------SVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1239
Query: 2015 GGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKE 2074
+ + + ++ S +SL SD+ +E +++ L+ +L++ K ++
Sbjct: 1240 KLRNEVTVLRGENA---SAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGN 1296
Query: 2075 QKKRQKERLKAQEASL 2090
+ E +AQE+ +
Sbjct: 1297 TDTQADEDERAQESQI 1312
Score = 74.3 bits (181), Expect = 2e-12
Identities = 251/1314 (19%), Positives = 512/1314 (38%), Gaps = 159/1314 (12%)
Query: 1118 TSTEKKSTLEPHSTLSPQEDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSSTSSKGKKG 1177
TST + P ST S ++ +A +PS+ S + A + S+ S S KKG
Sbjct: 151 TSTASMVSSSP-STPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSI-KKG 208
Query: 1178 KKEKTEWLDSFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTDSTLEDLS 1237
++E + +R G K+G L DF + L++
Sbjct: 209 EREL------------------KIGDRVLVGGTKAGVVRFLGETDFAKGEWCGVELDEPL 250
Query: 1238 GHSVSVSSDKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSS----VMPPTITGFKPN 1293
G + + Q P L K + T+ ++K++ VM T K +
Sbjct: 251 GKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVMATTSASLKRS 310
Query: 1294 APLTDLNPAASRTTTENMAPIPGSKRFSPAGL----HHRMAAELSYLNAIEESVRQLSD- 1348
P+AS ++ + S R S GL R A ++S A++E++++
Sbjct: 311 -------PSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQH 363
Query: 1349 VERVRGISLAQQESVSLAQIIKAQQQ--RHERDLALLKLKAEQEALESQRQLEETRNKAA 1406
+E+ L + + A++ KA E++LAL + +Q LE + ++++ R
Sbjct: 364 IEQ-----LLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVE 418
Query: 1407 QVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELTRT----- 1461
E ++ + Q + E +V ++ ++ + L T + + EL ++
Sbjct: 419 AADREKVELLNQLEEEKRKV-EDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEK 477
Query: 1462 --------HISDAVVASGAPLAILYDHQRQHL--PDFVKQLRTRTETDRKSPSVSLSQSK 1511
+ D VA+ + + + + ++ V +LR R E+++ + V +S S
Sbjct: 478 TKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSL 537
Query: 1512 EGTLDSKHQKYSASY-DSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIE 1570
+ S +K + D E + K H + ++E ++ + E K N E ++
Sbjct: 538 LQEISSLQEKLEVTRTDHQREITSLKEHFGAREE-THQKEIKALYTATEKLSKEN-ESLK 595
Query: 1571 SSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIAT------EYSLKFDESMTEDEIEEQSF 1624
S ++ + +D V +L K T+IA+ E + F + + + E
Sbjct: 596 SKLEHANKENSD-------VIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAEL 648
Query: 1625 RSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMV 1684
++ + + + E + E A+ K + +L ++S ++
Sbjct: 649 KTQI-EKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLD 707
Query: 1685 RQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQR 1744
+ E++ + +L +L+E +K K EL L+ K + + K D+ L+ +
Sbjct: 708 KA---EDQHLVEMEDTLNKLQEAEIKVK---ELEVLQ-AKCNEQTKVIDNFTSQLKATEE 760
Query: 1745 GLL----LRL--QQEKAEIKRLQEANKAARKE-RQLILKQQEEIEKIRQTTIKLQEKLKS 1797
LL LR + K+E+K+L++ +AA K+ + L +++ E K T +LQ +
Sbjct: 761 KLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGR--- 817
Query: 1798 AGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKF 1857
E KL + ++ ++ ++ +L+ + +S E S+ + +++ +++ +K
Sbjct: 818 --ELKLTNLQENLSEVSQVKETLEKELQILKEK-FAEASEEAVSVQRSMQETVNKLHQKE 874
Query: 1858 ----------------LTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQM---EKQALA 1898
L E K ++ + E+L++ K +L+ + AEI +M L
Sbjct: 875 EQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLT 934
Query: 1899 AWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPS 1958
+ EL + +EL+ + T+ E AS + + + + +E S E E
Sbjct: 935 KMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMT-VKAEQSQQEAAKKHEEEKKEL 993
Query: 1959 ES--IGQEQPGSPDHSILTEEMICSQELESSTSPSKH-----SLPKSCTSVSKQESSKGS 2011
E E+ H+ +E+ E +S + +KH +L K T + ++ KG+
Sbjct: 994 ERKLSDLEKKMETSHN-QCQELKARYERATSETKTKHEEILQNLQK--TLLDTEDKLKGA 1050
Query: 2012 HRTGGQC-----HLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKS 2066
L ++ + + + E + T ++++ + K K ++
Sbjct: 1051 REENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQN 1110
Query: 2067 VVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLS 2126
++ LK+ K +E K++E ++ + +EF K ++ET A Q
Sbjct: 1111 ELDTLKENNLKNVEELNKSKELLTVEN-QKMEEFRK--------EIETLKQAAAQKSQQL 1161
Query: 2127 SASEKPKIKPLTPLHRSETAKNWKSLTESERS--RGSLESIAEHVDASL--SGSERSVSE 2182
SA ++ +K L RS E ERS L + + + + E++ +
Sbjct: 1162 SALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQ 1221
Query: 2183 RSLSAYAKRVNEWDSRTEDFQTPSPVLR---SSRKIREESGDSLEN------VPALHLLK 2233
+S+S + + E D+ E + VLR +S K +LE+ + +L
Sbjct: 1222 KSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL 1281
Query: 2234 ELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLE--- 2290
+L R L S G + + E + S I D K + ++++ E
Sbjct: 1282 QLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAAL 1341
Query: 2291 --QGDSSEILSKKDLPLDSENVQKDLVGLA-IENLHKSEEMLKERQSDQDMNHS 2341
GD D S+ + + +LH +E+ + Q +D HS
Sbjct: 1342 NGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHS 1395
Score = 58.5 bits (140), Expect = 1e-07
Identities = 172/839 (20%), Positives = 339/839 (40%), Gaps = 97/839 (11%)
Query: 1684 VRQYMKEEEMRAAHQSSLLRLR--EKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRK 1741
+++ +KE++ H LL R E+A K + + +E + RD G D + L
Sbjct: 353 LQEALKEKQQ---HIEQLLAERDLERAEVAKATSHVGEIEQELALARD-GHDQHVLELEA 408
Query: 1742 KQRGLLLRLQQEKAEIKRLQEANKAARKERQLI-LKQQEEIEKIRQTTIKLQEKLKSAGE 1800
K L R E A+ ++++ N+ ++R++ L+ + E E I + ++ Q KL+ A
Sbjct: 409 KMDQL--RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARI 466
Query: 1801 SKLD-SHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
+L+ S + TK +K +LE + +S E S IM+ K + R+ E
Sbjct: 467 KELEQSLLFEKTKADKLQR----ELEDTRVATVS----EKSRIMELEKDLALRVQEVAEL 518
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDA--EEAEIRQMEKQALAAWDKELI--KPKTPKKELE 1915
+R + + + L + + + E+ E+ + + Q KE + +T +KE++
Sbjct: 519 RRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIK 578
Query: 1916 DQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVE-YVPSESIGQEQPGSPDHSIL 1974
T ++++ E ES H N E+S L +E + S E+ L
Sbjct: 579 ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL 638
Query: 1975 TEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDE 2034
E EL++ + ++ Q+ S+ + +H
Sbjct: 639 GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERA------------AHAKEMEALRA 686
Query: 2035 SLSMTQSETTSDQSDIEGRIRALKDE-LRKRKSVVNQLKK-EQKKRQKERLKAQEASLIK 2092
L E + I ++ +D+ L + + +N+L++ E K ++ E L+A+ K
Sbjct: 687 KLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK 746
Query: 2093 QLESYDEFIKKTEAELSQDLE----TSPTAKPQIKTLSSASE--KPKIKPLTPLHRSETA 2146
++++ +K TE +L DL+ S K ++K L E + +IK L +E++
Sbjct: 747 VIDNFTSQLKATEEKL-LDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESS 805
Query: 2147 K----------NWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYA------K 2190
K LT + + + + E ++ L + +E S A + +
Sbjct: 806 KASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE 865
Query: 2191 RVNEWDSRTEDFQTPSPVLRSSR--------KIREESGDSLENVPALHLLKELNATSRIL 2242
VN+ + E F S L R K RE+ + + A L+ N + I+
Sbjct: 866 TVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLE--NDIAEIM 923
Query: 2243 DMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSK-- 2300
MS + +K + + +LK+ +E ++ LKL + +++ L K
Sbjct: 924 KMSGDNSSQLTKMN-----DELRLKERDVE---------ELQLKLT-KANENASFLQKSI 968
Query: 2301 KDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKD 2360
+D+ + +E Q++ E + E L + + + +H+ Q K +E+ ++ K
Sbjct: 969 EDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHN-QCQELKARYERATSETK- 1026
Query: 2361 LSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMR 2420
+ E + + + + +E ++ L ++ E+ K +Q+ D Q M
Sbjct: 1027 -TKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIME 1085
Query: 2421 SSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLE--LKSPTELMKSKERSDVEHEQ 2477
T T E ++ K + D L E LK+ EL KSKE VE+++
Sbjct: 1086 QMTKEKT-----ETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQK 1139
Score = 57.4 bits (137), Expect = 2e-07
Identities = 217/1157 (18%), Positives = 427/1157 (36%), Gaps = 147/1157 (12%)
Query: 1796 KSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDE 1855
+S S L S S + ++ P T L T + S + S T+++ + LK+ + + E
Sbjct: 309 RSPSASSLSSMSS--VASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHI-E 365
Query: 1856 KFLTKR-----------------EQKL-MQRRQHAEELLEWKRRLDAEEAEIRQMEKQAL 1897
+ L +R EQ+L + R H + +LE + ++D ++R M + A
Sbjct: 366 QLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMD----QLRTMVEAA- 420
Query: 1898 AAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVP 1957
D+E K EL +Q E+K + + V S + +L ++ +
Sbjct: 421 ---DRE-------KVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELE 470
Query: 1958 SESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQ 2017
+ ++ L + + + +S + L V++ S++ G
Sbjct: 471 QSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGD 530
Query: 2018 CHLPIKSHQHCYSWSDESLSMT----QSETTSDQSDIEGRIRALKDELRKRKSVVNQLKK 2073
+ + Q S E L +T Q E TS + R + E++ + +L K
Sbjct: 531 VDMSLSLLQEISSLQ-EKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSK 589
Query: 2074 EQK----------KRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIK 2123
E + K + + ++ L + S+ + +++ + S+ L T ++K
Sbjct: 590 ENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELK 649
Query: 2124 T------LSSASEKPKIKPLTPLHRSETAKNWKSLTES-----ERSRGSLESIAEHVDAS 2172
T L E ++ R+ AK ++L + SLE+I +D +
Sbjct: 650 TQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKA 709
Query: 2173 LSG------------SERSVSERSLSAYAKRVNEW----DSRTEDFQTPSPVLRSSRKIR 2216
E + + L + NE D+ T + L +R
Sbjct: 710 EDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALR 769
Query: 2217 EESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEI-KEIEYTKLKKSKIEDAF 2275
+ S + + L E A +I + K ESSK S I +E++ +LK + +++
Sbjct: 770 KASSEGKSEMKKLRQQLEA-AEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENL 828
Query: 2276 SKEGKSDVLLKLVLEQGDSSEILSKKDLPLDSE--NVQKDLVGLAIENLHKSEEMLKERQ 2333
S+ + +K LE+ +IL +K E +VQ+ + + LH+ EE
Sbjct: 829 SEVSQ----VKETLEK--ELQILKEKFAEASEEAVSVQRSMQE-TVNKLHQKEEQFNMLS 881
Query: 2334 SDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELY 2393
SD + N+ + +K+ +E E L KE ++ E+ + S++L
Sbjct: 882 SDLEKLRE-NLADMEAKFREKDERE------EQLIKAKEKLENDIAEIMKMSGDNSSQLT 934
Query: 2394 KDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEISECLSEKSLSIHSNVHSD 2453
K + E LR + + + + A+ + E +E+S + H +
Sbjct: 935 KMNDE------LRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE 988
Query: 2454 RLLELKSPTELMKSKERSDVEHEQQVTESPSLASVPTADELFDFHIGDRVLIGNVQPGIL 2513
EL+ ++ K + Q++ A+ T + ++ N+Q +L
Sbjct: 989 EKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTK-------HEEILQNLQKTLL 1041
Query: 2514 ----RFKGETSFAKGFWAGVE-----LDKPEGNNNGTYDGIAYFE--CKEKHGIFAPPQK 2562
+ KG G +E DK + D + E KEK A +
Sbjct: 1042 DTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAE-DAMQIMEQMTKEKTETLASLED 1100
Query: 2563 ISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDRE--KDVSEYFYEKSLPSV 2620
+ +D ++ + + E ++E E K E K++ E + +
Sbjct: 1101 TKQTNAKLQNELDTLKENNLKNVEELN-KSKELLTVENQKMEEFRKEI-ETLKQAAAQKS 1158
Query: 2621 NDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQI--SSKENKDLISDATE-KV 2677
+ A + L E +D + ++S +++Q+ K I DA E K
Sbjct: 1159 QQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKA 1218
Query: 2678 SIAAEDDTLDNTFSEELEKQQQFTEEEDNLYAE-ASEKLCTPLLDLLTREKNQLEAQLKS 2736
S+ +E+ + ++ E L E AS K ++ L +K +LE ++K+
Sbjct: 1219 SLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKN 1278
Query: 2737 SLNEEKKSKQQLEKISLLTDSLLKV----------FVKDTVNQLQQIKKTRDEKIQLSNQ 2786
+ K++K+QL S TD+ F+ + LQ+ + K+++ ++
Sbjct: 1279 LELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
Query: 2787 ELL---GDDQKKVTPQDLSQNVEEQSP---SISGCFLSSELEDEKEEISSPDMCPRPESP 2840
L GDD D + +++ I CF + ED + + P S
Sbjct: 1339 AALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSE--DPPHST 1396
Query: 2841 VFGASGQEELAKRLAEL 2857
G+ G+E + E+
Sbjct: 1397 HHGSRGEERPYCEICEM 1413
Score = 52.8 bits (125), Expect = 5e-06
Identities = 184/1026 (17%), Positives = 391/1026 (38%), Gaps = 144/1026 (14%)
Query: 1492 LRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQES 1551
+ T + + ++SPS S S S + S + SS Y R+ S ++ QE+
Sbjct: 300 MATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYA---RKISGTTALQEA 356
Query: 1552 PSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDS-TSIATEYSLKF 1610
KE ++ + E + E+ + A S + L +D E K
Sbjct: 357 -----LKEKQQHIEQLLAERDL-ERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKM 410
Query: 1611 DESMTEDEIEEQSFRSLLPS-ESHRR------FNMEKRRGHHDDSDEEASPEKTTLSTAK 1663
D+ T E ++ LL E +R F +E+ D + + E + K
Sbjct: 411 DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARI---K 467
Query: 1664 ELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQ 1723
EL F K + +++ +++ + + S + EK L + + E+A L +
Sbjct: 468 ELEQSLL-----FEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQ-EVAELRRR 521
Query: 1724 KKHLRDKGEDDKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQ---QEE 1780
+ + G+ D L ++ L QEK E+ R + + ++ Q+E
Sbjct: 522 LESNKPAGDVDMSLSLLQEISSL-----QEKLEVTRTDHQREITSLKEHFGAREETHQKE 576
Query: 1781 IEKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKAT------------SPGPTDLETRS 1828
I+ + T KL ++ +S +SKL+ H++ + D A +L+
Sbjct: 577 IKALYTATEKLSKENESL-KSKLE-HANKENSDVIALWKSKLETAIASHQQAMEELKVSF 634
Query: 1829 PSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRL----DA 1884
+ ++E + + +++KMR + + Q+ +R HA+E+ + +L
Sbjct: 635 SKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE 694
Query: 1885 EEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIA---SEEESPVPLYSHLNSE 1941
+E + + + A D+ L++ + +L++ + KE+ ++ + + S+
Sbjct: 695 KENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQ 754
Query: 1942 SSIPEE--LGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSC 1999
EE L A+ SE E E+ I E+E + SK S
Sbjct: 755 LKATEEKLLDLDALRKASSEG-KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS----- 808
Query: 2000 TSVSKQESSKGSHRTGGQCHLP-IKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALK 2058
S++++ + T Q +L + + + L +E + + ++ ++
Sbjct: 809 -SITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETV 867
Query: 2059 DELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTA 2118
++L +++ N L + +K +E L EA ++ E ++ IK E +L D+ A
Sbjct: 868 NKLHQKEEQFNMLSSDLEKL-RENLADMEAKFREKDEREEQLIKAKE-KLENDI-----A 920
Query: 2119 KPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSER 2178
+ + ++S+ K+ L + + LT++ + L+ E + S++
Sbjct: 921 EIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQ 980
Query: 2179 SVS---ERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKEL 2235
+ E +++++ + + E L K R E S +L+ L
Sbjct: 981 EAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL----KARYERATSETKTKHEEILQNL 1036
Query: 2236 NATSRILDMSDGKVGESSKKSEI-KEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDS 2294
T +LD D G + S + +E+E + + K + A + E ++ ++ E+ ++
Sbjct: 1037 QKT--LLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTET 1094
Query: 2295 SEILSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQK 2354
+ S +D + +Q +L L
Sbjct: 1095 --LASLEDTKQTNAKLQNELDTL------------------------------------- 1115
Query: 2355 NTKEKDLSWSEHLFAPKEIPYSEDFEVSSFKKEIS-------------AELYKDDFEVSS 2401
KE +L E L KE+ E+ ++ F+KEI + L +++ +++
Sbjct: 1116 --KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAE 1173
Query: 2402 LLSLRKDSQSCRDKPQPMRSSTSG--------ATSFGSNEEISECLSEKSLSIHSNVHSD 2453
L +D + K + RS + + F + + + +KS+SI S + ++
Sbjct: 1174 ELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTE 1233
Query: 2454 RLLELK 2459
+ EL+
Sbjct: 1234 KDAELE 1239
Score = 47.0 bits (110), Expect = 3e-04
Identities = 182/916 (19%), Positives = 359/916 (39%), Gaps = 155/916 (16%)
Query: 2131 KPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAK 2190
+PK P+H+ T + S T ++ ++ + ASL S + S S+S+ A
Sbjct: 266 QPKYGLFAPVHKV-TKIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVAS 324
Query: 2191 RVNEWDSRTEDFQTPSPVLRSSRKIR---------EESGDSLENVPA---LHLLKELNAT 2238
V+ SRT S R +RKI +E +E + A L + AT
Sbjct: 325 SVSSRPSRTGLLTETSS--RYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKAT 382
Query: 2239 SRILDMS-------DG----------------KVGESSKKSEIKEIEYTKLKKSKIED-A 2274
S + ++ DG + E++ + +++ + + +K K+ED
Sbjct: 383 SHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQ 442
Query: 2275 FSKEGKSDVLLKLVLEQGDSSEILSKKDL-------PLDSENVQKDLVGLAIENLHKSEE 2327
F E +S + K LE E K+L ++ +Q++L + + +
Sbjct: 443 FRVEEES--ITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSR 500
Query: 2328 MLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWS-----EHLFAPKEIPYSE-DFEV 2381
++ E + D + + + + K + D+S S L E+ ++ E+
Sbjct: 501 IM-ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREI 559
Query: 2382 SSFKKEISAELYKDDFEVSSLLS----LRKDSQSCRDKPQPMRSSTSGA---------TS 2428
+S K+ A E+ +L + L K+++S + K + S T+
Sbjct: 560 TSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETA 619
Query: 2429 FGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESPSLASV 2488
S+++ E L + S S + ELK+ E M+ + ++E+ Q +S A
Sbjct: 620 IASHQQAMEEL-KVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAH- 677
Query: 2489 PTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYF 2548
A E+ +I + + + + A+ L + E N + A
Sbjct: 678 --AKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE----DQHLVEMEDTLNKLQE--AEI 729
Query: 2549 ECKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDR---- 2604
+ KE + A + + + +NF + E++ D + ++ +++ + + +
Sbjct: 730 KVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA 789
Query: 2605 EKDVSEYFYEKSLPSVNDIEASVNR---SRSLKIET--DNVQDISGVLEAHVHQ------ 2653
EK + EK+ S +S+ R R LK+ +N+ ++S V E +
Sbjct: 790 EKQIKHLEIEKNAESSK--ASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE 847
Query: 2654 ------QSSVDSQISSKENKDLISDATEKVSIAAED--------DTLDNTFSEELEKQQQ 2699
+ +V Q S +E + + E+ ++ + D ++ F E+ E+++Q
Sbjct: 848 KFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQ 907
Query: 2700 FTEEEDNLYAEASE--KLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDS 2757
+ ++ L + +E K+ LT+ ++L + + + K + E S L S
Sbjct: 908 LIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKS 967
Query: 2758 LLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKV-TPQDLSQNVEEQSPSISGCF 2816
+ + VK +Q + KK +EK +L + L D +KK+ T + Q ++ +
Sbjct: 968 IEDMTVKAEQSQQEAAKKHEEEKKELERK--LSDLEKKMETSHNQCQELKARYER----- 1020
Query: 2817 LSSELEDEKEEI--SSPDMCPRPESPVFGASGQEELAKRLAELELSREFLSALGDDQDWF 2874
+SE + + EEI + E + GA +EE + L ELE R+
Sbjct: 1021 ATSETKTKHEEILQNLQKTLLDTEDKLKGA--REENSGLLQELEELRK------------ 1066
Query: 2875 DEDFGLSSSHKIQKNKAEETIVPLMAEPKRVTQQPCETLLAVPHTAE-------EVEILV 2927
+ K KA +T M +++T++ ETL ++ T + E++ L
Sbjct: 1067 ----------QADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLK 1116
Query: 2928 HN---AAEELWKWKEL 2940
N EEL K KEL
Sbjct: 1117 ENNLKNVEELNKSKEL 1132
Score = 32.0 bits (71), Expect = 9.8
Identities = 47/217 (21%), Positives = 89/217 (41%), Gaps = 39/217 (17%)
Query: 471 AESDPRLDVLHRHLQRNSERSRSKSRSEN----NIKKLASSLPD--------NKQEENTA 518
AE+ + R +Q + K N +++KL +L D +++EE
Sbjct: 850 AEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLI 909
Query: 519 LNKDFLPIEIRGILDDLQLDSTAHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKIT- 577
K+ L +I I+ +S+ T D + L+ + V+ K+T
Sbjct: 910 KAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERD-------------VEELQLKLTK 956
Query: 578 ANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQELYRKQK 637
ANE+ + K T + Q Q+E +K EEKK + ++L +L +K +
Sbjct: 957 ANENASFLQKSIEDMTVKAEQ----SQQEAAKKHEEEKK-------ELERKLSDLEKKME 1005
Query: 638 EAFTKVKNVPPSEPSATRRLQETYSKLL--LEKTLLE 672
+ + + + AT + + ++L L+KTLL+
Sbjct: 1006 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD 1042
>gi|116008447 CAP-GLY domain containing linker protein 2 isoform 1
[Homo sapiens]
Length = 1046
Score = 97.8 bits (242), Expect = 1e-19
Identities = 93/383 (24%), Positives = 161/383 (42%), Gaps = 25/383 (6%)
Query: 2426 ATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTE--LMKSKERSDVEHEQQVTESP 2483
A GS+ E L+ ++LS+HS + L P ++ S ++ E +++S
Sbjct: 151 AEGSGSDAHSVESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGNESGSNLSDS- 209
Query: 2484 SLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYD 2543
SV ++ D +GDRVL+G + G++R+ GET FAKG W GVELD+P G N+G
Sbjct: 210 --GSVKRGEK--DLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVA 265
Query: 2544 GIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKD 2603
G YF+C K G+FAP K+ I + + ++ +
Sbjct: 266 GTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSS 325
Query: 2604 REKDV------SEYFYEKSLPSVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSV 2657
V S E S I + +LK + +++ + + + +
Sbjct: 326 VASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKA 385
Query: 2658 DSQISSKENKDLISDATEKVSIAAEDDTL-------DNTFSEELEKQQQFTEE----EDN 2706
S I E + + A + +A ++ L ++ E+++ Q EE ED
Sbjct: 386 TSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDL 445
Query: 2707 LYAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDT 2766
+ E + L+ T+ ++ +L+ SL EK ++L + L + L V K
Sbjct: 446 QFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLR-ELADNRLTTVAEKSR 504
Query: 2767 VNQLQQIKKTRDEKIQLSNQELL 2789
V QL++ R +I+ Q LL
Sbjct: 505 VLQLEEELTLRRGEIEELQQCLL 527
Score = 84.7 bits (208), Expect = 1e-15
Identities = 45/112 (40%), Positives = 62/112 (55%), Gaps = 11/112 (9%)
Query: 2467 SKERSDVEHEQQ-VTESPSLASVPTA----------DELFDFHIGDRVLIGNVQPGILRF 2515
SKE S + + + SP+ A+ P D L DF +G+RV + V+PG++++
Sbjct: 38 SKEGSPLHKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQY 97
Query: 2516 KGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIP 2567
GET FA G WAGV LD P G N+G G+ YFEC GIF P K++ P
Sbjct: 98 LGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQP 149
Score = 50.4 bits (119), Expect = 3e-05
Identities = 172/855 (20%), Positives = 330/855 (38%), Gaps = 149/855 (17%)
Query: 1123 KSTLEPHSTLSPQEDHSNRKSAYDPSSVDVTSQHSSGAQSAASSR------SSTSSKGKK 1176
K T +P + S + HS + + S HS A +SR S +S K
Sbjct: 144 KLTRQPTAEGSGSDAHS-----VESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKT 198
Query: 1177 GKKEKTEWLDSFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTDSTLEDL 1236
G + + DS G+V+ D +R G K+G + DF + L++
Sbjct: 199 GNESGSNLSDS--GSVKRGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEP 256
Query: 1237 SGHSVSVSSDKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPL 1296
G + + Q P L K ++ TS ++K + ++P
Sbjct: 257 LGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSP- 315
Query: 1297 TDLNPAASRTTTENMAPIPGSKRFSPAGL----HHRMAAELSYLNAIEESVRQLSD-VER 1351
++S ++ ++A G R S +GL R A ++S A++E++++ +E+
Sbjct: 316 ----SSSSISSVSSVASSVGG-RPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQ 370
Query: 1352 VRGISLAQQESVSLAQIIKAQQQ--RHERDLALLKLKAEQEALESQRQLEETRNKAAQVH 1409
L + + A++ KA E+++ALLK + EQ E++ +L+ R V
Sbjct: 371 -----LLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVR 425
Query: 1410 AESLQ---QVVQSQREVTEV---------------------------------LQEATCK 1433
E + Q+ + +R+V ++ L++A +
Sbjct: 426 KEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAE 485
Query: 1434 IAAQQSETARLTTDAAR----QICEMAELTRTHISD---AVVASGAPLAILYDHQRQHLP 1486
++ RLTT A + Q+ E L R I + ++ SG P DH P
Sbjct: 486 RLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPP---DH-----P 537
Query: 1487 DFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGS 1546
D + LR R +R + Q + G L K++K +Y + + R+++
Sbjct: 538 DAAEILRLR---ERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKL-------RAANEK 587
Query: 1547 SRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEY 1606
QE V K+ ++ E + + + + DSL SD SL D K +
Sbjct: 588 YAQE---VAGLKDKVQQATSENMGLMDNWKSKL---DSLASDHQKSLEDLKAT------- 634
Query: 1607 SLKFDESMTEDEIEEQSFRSLLPS-ESHRRFNMEKRRGHHDDSDEEASPEKTTL-STAKE 1664
L + EI E ++++ + + + + HD EK L +E
Sbjct: 635 -LNSGPGAQQKEIGE--LKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQE 691
Query: 1665 LNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQK 1724
+G Q R + + E++A+ L L+E A ++ AEL E +K
Sbjct: 692 AQEELAGLQ-----------RHWRAQLEVQASQHR--LELQE-AQDQRRDAELRVHELEK 737
Query: 1725 KHLRDKGEDDKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKI 1784
+ +G+ + L+++ + +++ + +RLQ A ++E ++ E +
Sbjct: 738 LDVEYRGQAQAIEFLKEQ----ISLAEKKMLDYERLQRAEAQGKQE----VESLREKLLV 789
Query: 1785 RQTTIKLQEKLKSAGESKLDSHSD--DDTKDNKATSPGPTDLETRSPSPISISSSETSSI 1842
+ ++ E L S+ + + +D ++T K T G D + ++ +S+T +
Sbjct: 790 AENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEML 849
Query: 1843 MQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQA---LAA 1899
++ + E K + + LL+ KRRL+AE + + A L
Sbjct: 850 RAQVSAL------------ESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVL 897
Query: 1900 WDKELIKPKTPKKEL 1914
+EL++ + EL
Sbjct: 898 ISQELLRKERSLNEL 912
>gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2
[Homo sapiens]
Length = 1011
Score = 96.3 bits (238), Expect = 4e-19
Identities = 96/388 (24%), Positives = 166/388 (42%), Gaps = 89/388 (22%)
Query: 2426 ATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTE--LMKSKERSDVEHEQQVTESP 2483
A GS+ E L+ ++LS+HS + L P ++ S ++ E +++S
Sbjct: 151 AEGSGSDAHSVESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGNESGSNLSDS- 209
Query: 2484 SLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYD 2543
SV ++ D +GDRVL+G + G++R+ GET FAKG W GVELD+P G N+G
Sbjct: 210 --GSVKRGEK--DLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVA 265
Query: 2544 GIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKD 2603
G YF+C K G+FAP K+ I
Sbjct: 266 GTRYFQCPPKFGLFAPIHKVIRI------------------------------------- 288
Query: 2604 REKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISS 2663
PS + +A + ++ + S + + SSV S +
Sbjct: 289 ------------GFPSTSPAKAKKTKRMAMGVSALTHSPSS----SSISSVSSVASSVGG 332
Query: 2664 KENKD-LISDATEKVSIAAEDDT-LDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLD 2721
+ ++ L+++ + + + T L E+ + +Q E D AE ++ T +
Sbjct: 333 RPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAK--ATSHIC 390
Query: 2722 LLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKI 2781
+ +E L+AQ + + E ++++L++ LL +S+ R EK+
Sbjct: 391 EVEKEIALLKAQHEQYVAE---AEEKLQRARLLVESV------------------RKEKV 429
Query: 2782 QLSNQELLGDDQKKVTPQDLSQNVEEQS 2809
LSNQ L ++++KV +DL VEE+S
Sbjct: 430 DLSNQ--LEEERRKV--EDLQFRVEEES 453
Score = 84.7 bits (208), Expect = 1e-15
Identities = 45/112 (40%), Positives = 62/112 (55%), Gaps = 11/112 (9%)
Query: 2467 SKERSDVEHEQQ-VTESPSLASVPTA----------DELFDFHIGDRVLIGNVQPGILRF 2515
SKE S + + + SP+ A+ P D L DF +G+RV + V+PG++++
Sbjct: 38 SKEGSPLHKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQY 97
Query: 2516 KGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIP 2567
GET FA G WAGV LD P G N+G G+ YFEC GIF P K++ P
Sbjct: 98 LGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQP 149
Score = 57.0 bits (136), Expect = 3e-07
Identities = 167/820 (20%), Positives = 322/820 (39%), Gaps = 114/820 (13%)
Query: 1123 KSTLEPHSTLSPQEDHSNRKSAYDPSSVDVTSQHSSGAQSAASSR------SSTSSKGKK 1176
K T +P + S + HS + + S HS A +SR S +S K
Sbjct: 144 KLTRQPTAEGSGSDAHS-----VESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKT 198
Query: 1177 GKKEKTEWLDSFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTDSTLEDL 1236
G + + DS G+V+ D +R G K+G + DF + L++
Sbjct: 199 GNESGSNLSDS--GSVKRGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEP 256
Query: 1237 SGHSVSVSSDKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPL 1296
G + + Q P L K ++ TS ++K + ++P
Sbjct: 257 LGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSP- 315
Query: 1297 TDLNPAASRTTTENMAPIPGSKRFSPAGL----HHRMAAELSYLNAIEESVRQLSD-VER 1351
++S ++ ++A G R S +GL R A ++S A++E++++ +E+
Sbjct: 316 ----SSSSISSVSSVASSVGG-RPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQ 370
Query: 1352 VRGISLAQQESVSLAQIIKAQQQ--RHERDLALLKLKAEQEALESQRQLEETRNKAAQVH 1409
L + + A++ KA E+++ALLK + EQ E++ +L+ R V
Sbjct: 371 -----LLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVR 425
Query: 1410 AES--LQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAE---LTRTHIS 1464
E L ++ +R E LQ + + + + T ++ ++ E L R I
Sbjct: 426 KEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIE 485
Query: 1465 D---AVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQK 1521
+ ++ SG P DH PD + LR R +R + Q + G L K++K
Sbjct: 486 ELQQCLLHSGPPPP---DH-----PDAAEILRLR---ERLLSASKEHQRESGVLRDKYEK 534
Query: 1522 YSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAA 1581
+Y + + R+++ QE V K+ ++ E + + + +
Sbjct: 535 ALKAYQAEVDKL-------RAANEKYAQE---VAGLKDKVQQATSENMGLMDNWKSKL-- 582
Query: 1582 DDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRSLLPS-ESHRRFNMEK 1640
DSL SD SL D K + L + EI E ++++ + + +
Sbjct: 583 -DSLASDHQKSLEDLKAT--------LNSGPGAQQKEIGE--LKAVMEGIKMEHQLELGN 631
Query: 1641 RRGHHDDSDEEASPEKTTL-STAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQS 1699
+ HD EK L +E +G Q R + + E++A+
Sbjct: 632 LQAKHDLETAMHVKEKEALREKLQEAQEELAGLQ-----------RHWRAQLEVQASQHR 680
Query: 1700 SLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLRLQQEKAEIKR 1759
L L+E A ++ AEL E +K + +G+ + L+++ + +++ + +R
Sbjct: 681 --LELQE-AQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQ----ISLAEKKMLDYER 733
Query: 1760 LQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLDSHSD--DDTKDNKAT 1817
LQ A ++E ++ E + + ++ E L S+ + + +D ++T K T
Sbjct: 734 LQRAEAQGKQE----VESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKET 789
Query: 1818 SPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLE 1877
G D + ++ +S+T + ++ + E K + + LL+
Sbjct: 790 VEGLQDKLNKRDKEVTALTSQTEMLRAQVSAL------------ESKCKSGEKKVDALLK 837
Query: 1878 WKRRLDAEEAEIRQMEKQA---LAAWDKELIKPKTPKKEL 1914
KRRL+AE + + A L +EL++ + EL
Sbjct: 838 EKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNEL 877
>gi|31982881 CAP-GLY domain containing linker protein family, member 4
[Homo sapiens]
Length = 705
Score = 94.0 bits (232), Expect = 2e-18
Identities = 60/229 (26%), Positives = 113/229 (49%), Gaps = 26/229 (11%)
Query: 2421 SSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVT 2480
S++ S EE+ + ++EK +++ +V S + K+ + +++ ++
Sbjct: 397 SASESTLSLPPGEEL-KTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMS 455
Query: 2481 ESPSLAS----------VPTADELF---DFHIGDRVLIGNVQPGILRFKGETSFAKGFWA 2527
+SPSL+S TA+ + +G+RVL+ + G +RF G T+FA G+W
Sbjct: 456 KSPSLSSRASAGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWY 515
Query: 2528 GVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDER 2587
G+EL+KP G N+G+ G+ YF C ++GIFAPP ++ + ++ D +I+ ++ +S
Sbjct: 516 GIELEKPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHS--- 572
Query: 2588 YQCYNQEQNDTEGPKDREKDVSEYFYE---------KSLPSVNDIEASV 2627
Y + + + T +E + F + S P+ IE SV
Sbjct: 573 YPGFRRSFSTTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIEGSV 621
Score = 83.6 bits (205), Expect = 3e-15
Identities = 38/66 (57%), Positives = 47/66 (71%)
Query: 2499 IGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFA 2558
+GDRV+I + G LRF G T FA G WAG+ELD+PEG NNG+ + YF+C K+GIFA
Sbjct: 285 LGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFA 344
Query: 2559 PPQKIS 2564
P KIS
Sbjct: 345 PLSKIS 350
Score = 62.4 bits (150), Expect = 7e-09
Identities = 34/98 (34%), Positives = 51/98 (52%), Gaps = 4/98 (4%)
Query: 2484 SLASVPTADEL---FDFHIGDRVLI-GNVQPGILRFKGETSFAKGFWAGVELDKPEGNNN 2539
S +S PTA + H G +VL+ + + G +R+ G T FA G W G+EL +G N+
Sbjct: 607 SWSSTPTAGGIEGSVKLHEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRSAKGKND 666
Query: 2540 GTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDIN 2577
G+ YF CK HG+ P ++++ N VD N
Sbjct: 667 GSVGDKRYFTCKPNHGVLVRPSRVTYRGINGSKLVDEN 704
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 91.7 bits (226), Expect = 1e-17
Identities = 219/1114 (19%), Positives = 446/1114 (40%), Gaps = 162/1114 (14%)
Query: 1335 YLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALES 1394
Y+ I E++R++ + ER+ A+QQR E L +++A ALE
Sbjct: 1333 YIKFISETLRRMEEEERL------------------AEQQRAEERERLAEVEA---ALEK 1371
Query: 1395 QRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCK-----IAAQQSETA------- 1442
QRQL A+ HA++ Q + +E+ + +QE + + AQQ + +
Sbjct: 1372 QRQL-------AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1424
Query: 1443 -RLTTDA-----ARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTR- 1495
R +++A ARQ E AE +R I + + L + QR ++ LR R
Sbjct: 1425 LRQSSEAEIQAKARQ-AEAAERSRLRIEEEIRVVRLQLEAT-ERQRGGAEGELQALRARA 1482
Query: 1496 --TETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPS 1553
E ++ + + D +K A + S R E
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1542
Query: 1554 VPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDES 1613
+ +E E++L ++E + QVQ A + + RS + + + E + + + S
Sbjct: 1543 L-QAEEAERRLRQAEVERA--RQVQVALETAQRSAEA----ELQSKRASFAEKTAQLERS 1595
Query: 1614 MTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQ 1673
+ E+ + R + ++ E+ R + E E+ L + L + +
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAR-----EEAERELERWQLKANEALRLRLQAEE 1650
Query: 1674 DSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGED 1733
+ K + + KEE R A + + E+A++++ ELA E +K+ R E
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRG--KAEEQAVRQR---ELAEQELEKQ--RQLAEG 1703
Query: 1734 DKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQE 1793
L +Q + LR + E+ E +R + AR +R+ Q+ +++ K++
Sbjct: 1704 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR-QELEAELAKVRA 1762
Query: 1794 KLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRM 1853
+++ SK + ++++++ S + E ++ ++ ++ ++ K+ R
Sbjct: 1763 EMEVLLASK--ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-- 1818
Query: 1854 DEKFLTKREQKLMQRRQHAEELLEWKRRLDAE------EAEIRQMEKQALAAWDKELIKP 1907
E+ ++R AE +L K E EAEI EK+A + L +
Sbjct: 1819 ------LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Query: 1908 KT-PKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQP 1966
+ ++ LE+Q + K A EE L +SE + Q
Sbjct: 1873 EAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSEL--------------------ERQK 1910
Query: 1967 GSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
G ++ + + +++E K S K+ ++ E G R+ + L K
Sbjct: 1911 G-----LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1965
Query: 2027 HCYSWSDESLSMTQSETTSDQSD-IEGRIRALKDELRKRKSVVNQL-----KKEQKKRQK 2080
+ L+ + + + ++ + A ++ R+RK+ + ++ K E+ +R +
Sbjct: 1966 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2025
Query: 2081 ERLK---------AQEASLIKQLESYDE----FIKKTEAELSQDLETSPTAKPQIKTLSS 2127
ER + AQEA+ K+L++ ++ +++ E EL Q L+ + Q++ +
Sbjct: 2026 ERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084
Query: 2128 ASEK--PKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSL 2185
A+ + + + E A++ + + E+ER + S E A+ + + +E+ E
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 2186 SAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREES----GDSLENVPALHL-LKELNATSR 2240
A A+R + Q + +K E++ + + L L L+E +
Sbjct: 2145 EA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2203
Query: 2241 ILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVL--LKLVLEQGDSSEIL 2298
+LD E ++ + + E + + E+ FS + + L LK +E + + IL
Sbjct: 2204 LLD-------EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256
Query: 2299 SKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKE 2358
KD N Q+ L A + +EE + + Q+ + + +D+ +Q+ E
Sbjct: 2257 RDKD------NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAE 2309
Query: 2359 KDLSWSEHLFAPKEIP-YSEDFEVSSFKKEISAE 2391
K L E + A +E + E+ +KE++ E
Sbjct: 2310 KML--KEKMQAVQEATRLKAEAELLQQQKELAQE 2341
Score = 73.6 bits (179), Expect = 3e-12
Identities = 227/1261 (18%), Positives = 480/1261 (38%), Gaps = 182/1261 (14%)
Query: 1339 IEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
I+ RQ ER R + + ++ V Q+ ++QR + L L+A E E+Q+
Sbjct: 1433 IQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK-- 1489
Query: 1399 EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAEL 1458
+ AQ AE L++ VQ + ++ ++A ++A++ A + R + + EL
Sbjct: 1490 -----RQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1541
Query: 1459 TRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSK 1518
R +A RQ + +Q++ ET ++S L QSK + K
Sbjct: 1542 -RLQAEEAE-----------RRLRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAEK 1588
Query: 1519 HQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQ 1578
+ S + R + ++Q++ + + +E E++L +++++ +++
Sbjct: 1589 TAQLERSLQEEHVAVAQL---REEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 1579 TAADDSLRSDSVPSLPDEKDSTSI---------ATEYSLKFDESMTEDEIEEQSFRSLLP 1629
A++ + S+ EK A E +++ E + E E+E+Q R L
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE-LAEQELEKQ--RQLAE 1702
Query: 1630 SESHRRFNMEKRRGHHDDSDEEASPEKTTLSTA-KELNMPFSGGQDSFSKFTMEM--VRQ 1686
+ +R E+ E+ ++ L L + + E+ VR
Sbjct: 1703 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1762
Query: 1687 YMK---------EEEMRAAHQSSLLRLREKALKEKTKAE----LAWLEHQKKHLRDKGED 1733
M+ EEE R+ + S RL +A + + AE L L + K R E+
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 1734 DKMPPLRKKQRGLLLRLQQ--EKAEIKRLQEA---NKAARKERQLILKQQEEIEKIRQTT 1788
D + +R L +L E +K E K A ER L + E ++ R
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882
Query: 1789 IKLQEK---------LKSAGESKLDSHS---DDDTKDNKATSPGPTDLETRSPSPISISS 1836
Q K L+ A +S+L+ +D + + L+ + ++
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK----ASFEKAA 1938
Query: 1837 SETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEE-------AEI 1889
+ + + +L ++RS ++ +K + +L RQ E +RR +AEE AE
Sbjct: 1939 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1998
Query: 1890 RQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELG 1949
++ A + E +K K + +R EQ+ + + L +E
Sbjct: 1999 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK------ 2052
Query: 1950 SPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSK 2009
+ + +Q L +E +L ++ + ++ +E+
Sbjct: 2053 --------AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA------EEARV 2098
Query: 2010 GSHRTGGQCHLPIKSHQHC-YSWSDESLSMTQSETTSD------QSDIEGRIRALKDELR 2062
+ R Q ++ + S +++ + Q++ ++ + + R +A + LR
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2158
Query: 2063 KRKSVVNQLKK-----EQKKRQKERLKAQEASLIKQLES-------YDEFIKKTEAEL-- 2108
++++ +++K EQ RQK +++ + +L QLE DE +++ +AE
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218
Query: 2109 -----SQDLETSPTAKPQIKTLSSASEKPKI---------KPLTPLHRSETAKNWKSLTE 2154
SQ E + + Q++ LS + + K T E A+ K + E
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278
Query: 2155 -------SERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSP 2207
+ + L +AE A +R+++E+ L + V E + +
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLA----QQRALAEKMLKEKMQAVQE----ATRLKAEAE 2330
Query: 2208 VLRSSRKIREESGDSLE---NVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYT 2264
+L+ +++ +E L+ A L +E R L+ + E S ++E ++
Sbjct: 2331 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390
Query: 2265 KLKKSKI---EDA--FSKEGK--SDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
++ +++ EDA F K+ + + L + L + ++ ++ + + +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 2318 AIENLHKSEEMLKERQS--DQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPY 2375
AI L + +E L++ +Q + + E + ++ LS + L +
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510
Query: 2376 SEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEI 2435
E ++ +L++D+ + L + Q + + + R S + E
Sbjct: 2511 QEKAKLE--------QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562
Query: 2436 SECLSEKSLSIHSNVHSDRLLE---------LKSPTELMKSKERSDVEHEQQVTESPSLA 2486
E + K + R E L+ +L++ + R+ + H ++VT S A
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2622
Query: 2487 S 2487
+
Sbjct: 2623 T 2623
Score = 73.6 bits (179), Expect = 3e-12
Identities = 180/910 (19%), Positives = 377/910 (41%), Gaps = 99/910 (10%)
Query: 1341 ESVRQLSDVERVRGISLAQQESV--SLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
E +Q + E R LA++ + +LA+ K Q+Q E D A + +AE+ E +
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842
Query: 1399 EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAEL 1458
E + ++ +++R + + ++ + + + A+ D ++ ++ +
Sbjct: 1843 GEATRLKTEAEIALKEKEAENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK- 1900
Query: 1459 TRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTE---TDRKSPSVSLSQSKEGTL 1515
SD+ + L QR+ + + + L+ E + + L + +
Sbjct: 1901 ----ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1956
Query: 1516 DSKHQKYSASYDSYSESSGYKNHDRRSSSGSSR-QESPSVPSCKENEKKLNGEKIE---S 1571
D+ K A ++ + +RR R Q+S + ++K E++E +
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016
Query: 1572 SIDEQVQTAADDSLRSDSVPSLPDEKDSTSI-ATEYSLKFDESMTEDEI-----EEQSFR 1625
++E + S L E + A E + F E E+ +EQS
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076
Query: 1626 SLLPSESH-RRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMV 1684
L E+ R E+ ++ EA+ + + A+ L S + + ++ +
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ--SAEEQAQARAQAQAA 2134
Query: 1685 RQYM-KEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQK---KHLRDKGEDDKMPPLR 1740
+ + KE E AA ++ + + AL++K A+ +H+K + LR K +
Sbjct: 2135 AEKLRKEAEQEAARRA---QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ-------- 2183
Query: 1741 KKQRGLLLRLQQEKA---------EIKRLQ-EANKAARKERQLILKQQEEIEKIRQTTIK 1790
+Q LRLQ E+ E++RL+ EA +AAR+ Q+ +EE+ +R +
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV----EEELFSVRVQMEE 2239
Query: 1791 LQEKLKSAGESK---LDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLK 1847
L KLK+ E++ L D+T+ + +S+++ E + + Q +
Sbjct: 2240 L-SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2298
Query: 1848 K---MRSRMDEKFLTKREQKLMQ--RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDK 1902
+ + + EK L ++ Q + + R + ELL+ ++ L E+A Q +K+ +A
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358
Query: 1903 ELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIG 1962
E + + ++ LE +R Q E+++E E + ++ + EE + +E IG
Sbjct: 2359 E--ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK--QAEEIG 2414
Query: 1963 QEQPGSPDHSILTEEMI-CSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLP 2021
++ + + T+E + Q LE S H + ++++ E K + + L
Sbjct: 2415 EKLHRT---ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-LQ 2470
Query: 2022 IKSHQHCYSWSDESLSMTQS---ETTSDQSDIEGRIRALKDELRKRKSV-------VNQL 2071
+KS + ++ L TQ+ S++ + R R ++ E K + + QL
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530
Query: 2072 KKEQKKRQ------KERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTL 2125
++EQ+++Q ++RL A ++ +E +++ + EL Q LE + ++
Sbjct: 2531 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-QQLEQQRRQQEELLAE 2589
Query: 2126 SSASEKPKIKPLTPLHRSETAKNWKSLTESE--------RSRGSLESIAEHVDA--SLSG 2175
+ + +++ L HR+ A + + +T S+ R +L+ A + S G
Sbjct: 2590 ENQRLREQLQLLEEQHRAALAHS-EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDG 2648
Query: 2176 SERSVSERSL 2185
R VS + L
Sbjct: 2649 LRRKVSAQRL 2658
Score = 62.8 bits (151), Expect = 5e-09
Identities = 154/835 (18%), Positives = 304/835 (36%), Gaps = 132/835 (15%)
Query: 1136 EDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSSTSSKGK---------KGKKEKTEWLD 1186
E+ R+ A + + ++ + Q A+ K K + ++E L
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037
Query: 1187 SFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTD-STLEDLSGHSVSVSS 1245
Q L EEKA + Q K+ ++ +QTL + S L+ L G + +
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKE---------QELQQTLQQEQSVLDQLRGEAEAARR 2088
Query: 1246 DKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASR 1305
+++ ++Q Q + A ER K S + A L A +
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 1306 TTTENMAPIPGSKRFSPAGLHHRMAAELS---YLNAIEESVRQLSDVER-VRGISLAQQE 1361
+ A L + AA+ + E+++RQ + VE+ + + L +E
Sbjct: 2145 EAARRA-------QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 1362 SVSLAQIIKAQQQR---HERDLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQ 1418
+ ++ + QR + A + + E+E + Q+EE A++ AE+ +++
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2257
Query: 1419 SQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELTRTHISDAVVASGAPLAILY 1478
+ LQE K+ E ARL+ AA++ + +L ++ A+
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSV-AAQEAARLRQLAEEDLAQ-------QRALAE 2309
Query: 1479 DHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNH 1538
++ + + R + E + L+Q + L + K + E+ G+
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL--QEDKEQMAQQLAEETQGF--- 2364
Query: 1539 DRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKD 1598
Q + ++ E E+++ + E + A
Sbjct: 2365 ----------QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR---------------- 2398
Query: 1599 STSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRF--NMEKRRGHHDDSDEEASPEK 1656
A E + +F + +EI E+ R+ L ++ +E +R D E
Sbjct: 2399 ----AEEDAQRFRKQ--AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452
Query: 1657 TTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLR----LREKALKEK 1712
L KE K E +K EEM+ Q LL+ L++ L EK
Sbjct: 2453 AELEREKE-------------KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2499
Query: 1713 TK--AELAWLEHQKKHLRDKGEDD--KMPPLRKKQRGLLLRLQQEKAE-IKRLQEANKAA 1767
++E +K L +D+ K LR++Q+ +++QE+ + ++EA +
Sbjct: 2500 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2559
Query: 1768 RKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLD--------------SHSDDDTKD 1813
+ + + ++QEE++++ Q + QE+L + +L +HS++ T
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQR-RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2618
Query: 1814 NKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKRE--QKLMQ---- 1867
A + + P + + E S + K R+ E + E Q+L Q
Sbjct: 2619 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTT 2678
Query: 1868 -----RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQ 1917
RR+ L+ + + + + AA ++L+ P T LE Q
Sbjct: 2679 VDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2733
Score = 58.2 bits (139), Expect = 1e-07
Identities = 132/715 (18%), Positives = 300/715 (41%), Gaps = 88/715 (12%)
Query: 1683 MVRQYMK--EEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLR 1740
+ QY+K E +R + L +++A + + AE+ +++ L + K R
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388
Query: 1741 KKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTT-IKLQEKLKSAG 1799
+ + L R+Q+E + R +EA A+++++ I QEE++++RQ++ ++Q K + A
Sbjct: 1389 EAKE-LQQRMQEE---VVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQAE 1441
Query: 1800 ESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
++ ++ T+ + R + + + + + +K +++ + + L
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQ-RGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1500
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRT 1919
++ Q QR++ AE L + + +AE A +Q QAL + + + ++ E +R
Sbjct: 1501 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1560
Query: 1920 EQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMI 1979
Q ++A E ++ S EL S + E+ + S+ E +
Sbjct: 1561 RQVQVALE-----------TAQRSAEAELQSKRASFA-------EKTAQLERSLQEEHVA 1602
Query: 1980 CSQ-ELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSM 2038
+Q E+ + + + +++E + + L +++ + +SL+
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA---QQKSLAQ 1659
Query: 2039 TQSETTSDQSDIEGRIRALKDE--LRKRKSVVNQLKKEQKKRQ---KERLKAQEASLIKQ 2093
++E ++++ E R R +E +R+R+ +L+K+++ + ++RL A++ + +
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719
Query: 2094 LESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLT 2153
E+ + E + L A+ Q + ++ ++ +++ R+E
Sbjct: 1720 AET-------EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE--------- 1763
Query: 2154 ESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSR 2213
L S A + S S SE+ S++ L A A R E + + + R
Sbjct: 1764 ----MEVLLASKARAEEESRSTSEK--SKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817
Query: 2214 KIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSK---KSEI----KEIEYTKL 2266
++ EE ++ R+L +GE+++ ++EI KE E +L
Sbjct: 1818 QLAEEDA-----------ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866
Query: 2267 KKSKIEDAFSK--------EGKSDVLLKLV-LEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
++ ++AF + + K+D+ +L L + SE+ +K L D+ Q+ V
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-QRRQVEE 1925
Query: 2318 AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKE 2372
I L S E +++ ++ + +D K E + + L A +E
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980
Score = 47.8 bits (112), Expect = 2e-04
Identities = 245/1386 (17%), Positives = 511/1386 (36%), Gaps = 225/1386 (16%)
Query: 1739 LRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLI-----LKQQEEIEKIRQTTIKLQE 1793
LR+ + L QQ E +RL E A K+RQL K Q E E ++ ++QE
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA-KELQQRMQE 1399
Query: 1794 KLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRM 1853
++ E+ +D+ + ++ L S + I + + + ++ R R+
Sbjct: 1400 EVVRREEAAVDAQ-----QQKRSIQEELQQLRQSSEAEIQAKARQAEAA----ERSRLRI 1450
Query: 1854 DEKFLTKREQKLMQRRQH--AEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPK 1911
+E+ R Q RQ AE L+ R AEEAE ++ + Q A + ++ ++ +
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQ-ALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
Query: 1912 K-----ELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEE-LGSPAVEYVPSESIGQEQ 1965
K EL + + E A E++ + L ++ E L VE + E
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE- 1568
Query: 1966 PGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSH 2025
T + EL+S + + S+ ++ + R ++
Sbjct: 1569 ---------TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE--------EAE 1611
Query: 2026 QHCYSWSDESLSMTQSETTSDQSDIEG----RIRALKDELRKRKSVVN---QLKKEQKKR 2078
+ ++ + ++E ++ ++ R+R +E+ ++KS+ + +KE+ +R
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 2079 QKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLT 2138
+ R E ++Q E ++ ++K + A+ ++ L + +E+ + +
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ--R 1729
Query: 2139 PLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSR 2198
L E A+ + + + R LE+ V A + E L++ A+ E S
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEM--------EVLLASKARAEEESRST 1781
Query: 2199 TEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEI 2258
+E +S +++ E+G E L E A R L E+ ++ ++
Sbjct: 1782 SE---------KSKQRLEAEAGRFRE-------LAEEAARLRAL------AEEAKRQRQL 1819
Query: 2259 KEIEYTKLKKSKIEDAFSKEGKSD-VLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
E EDA + +++ VL + + G+++ + ++ ++ L + + +
Sbjct: 1820 AE-----------EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE---- 1864
Query: 2318 AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSE 2377
+ L + E + R +Q H DI E+
Sbjct: 1865 RLRRLAEDEAFQRRRLEEQAAQHKA------DIEER------------------------ 1894
Query: 2378 DFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNE---E 2434
++ +K +EL + V L R+ + ++ +++S A + G E E
Sbjct: 1895 ---LAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKASFEKAAA-GKAELELE 1947
Query: 2435 ISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESPSLASVPTADEL 2494
+ S ++ S ++ LE +L +ER E E++V +S +
Sbjct: 1948 LGRIRSNAEDTLRSKEQAE--LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005
Query: 2495 FDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKH 2554
+R+ + LR + E A+ E + + +EK
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR------------LQAEEKA 2053
Query: 2555 GIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYE 2614
FA QK E Q QEQ+ + + E + + E
Sbjct: 2054 HAFAVQQK---------------------EQELQQTLQQEQSVLDQLRG-EAEAARRAAE 2091
Query: 2615 KSLPSVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKE-NKDLISDA 2673
++ + E +SR E + ++ A Q+ +Q ++++ K+ +A
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEEAERLKQ-----SAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 2674 TEKVSIAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLL---------DLLT 2724
+ E+EK ++F E+ A+ ++L T L +LL
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 2725 REKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLS 2784
E +L+A+ + + + +++L + + + L K+ + I + +D +
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266
Query: 2785 NQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDE--------KEEISSPDMCPR 2836
+E + K+V + +V Q + +L + KE++ + R
Sbjct: 2267 QEE--AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 2837 PESPVFGASGQEELAKRLA-ELELSREFLSALGDDQDWFDEDFGLSSSHKIQKNKAEETI 2895
++ Q+ELA+ A L+ +E ++ Q +E G + + ++ + E
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMA-----QQLAEETQGFQRTLEAERQRQLE-- 2377
Query: 2896 VPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKELGHDLHSISIPTKLLG 2955
+ AE +R+ + E A E+ + A +E+G LH + T+
Sbjct: 2378 --MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLHRTELATQEKV 2428
Query: 2956 CASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMKPCRINSSYFRRVKNP 3015
+ L+I+ R + +E E+ E L Q K ++ S + V+
Sbjct: 2429 TLVQTLEIQ----RQQSDHDAERLREAIAELEREKEKLQQEA--KLLQLKSEEMQTVQQE 2482
Query: 3016 NNLDEIKSFIASEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVDHILVQELHEEEAQWV 3075
L E ++ S + + SL + + Q+ K + +D V Q+L EE+ +
Sbjct: 2483 QLLQETQALQQSFLSEKDSLLQ--RERFIEQEKAKLEQLFQDEV--AKAQQLREEQQRQQ 2538
Query: 3076 NYDEDE 3081
E E
Sbjct: 2539 QQMEQE 2544
Score = 47.4 bits (111), Expect = 2e-04
Identities = 109/504 (21%), Positives = 195/504 (38%), Gaps = 71/504 (14%)
Query: 1749 RLQQEKAEIKRLQEANKAA---RKERQLILKQQEEIEKI------RQTTIKLQEKLKSAG 1799
RL E ++ L E + AA R E +L L + E++ + + TI L +
Sbjct: 1042 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1101
Query: 1800 ESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
E L +H ++ K+ +A +LE T + ++KL+ F
Sbjct: 1102 EEVLRAH-EEQLKEAQAVPATLPELEA------------TKASLKKLRAQAEAQQPTFDA 1148
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRT 1919
R++ L ++ E L + D E R+ Q L W L + ++ELE
Sbjct: 1149 LRDE-LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQL-- 1205
Query: 1920 EQKEIASEEESPVPLYSHLNSESSIPEELGSP--AVEYVPSESIGQEQPGSPD---HSIL 1974
+++ ES PL + L E++ + A E + QEQ + H
Sbjct: 1206 -GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264
Query: 1975 TEE--------MICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
EE + ++ E K L + K + GS Q ++ +++H
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTH- 1322
Query: 2027 HCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQ 2086
SE T+ S I+ + + LR R +L ++Q+ ++ERL
Sbjct: 1323 -------------YSELTTLTSQY---IKFISETLR-RMEEEERLAEQQRAEERERLAEV 1365
Query: 2087 EASLIKQLESYDEFIK-KTEA-----ELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPL 2140
EA+L KQ + + + K +A EL Q ++ + + + ++ + L L
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 2141 HRSETAK---NWKSLTESERSRGSLESIAEHVDASLSGSE--RSVSERSLSAYAKRVNEW 2195
+S A+ + +ERSR +E V L +E R +E L A R E
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485
Query: 2196 DSRTEDFQTPSPVLRSSRKIREES 2219
+++ Q + LR R++++ES
Sbjct: 1486 EAQKRQAQEEAERLR--RQVQDES 1507
Score = 39.7 bits (91), Expect = 0.047
Identities = 64/315 (20%), Positives = 125/315 (39%), Gaps = 31/315 (9%)
Query: 358 EAEFQNMSRELYRDLALHFADDISIKEKPAEKSKEKKV-------VKPVRKVQKVAQLSS 410
EAE +EL ++ A +D KE+ A++ E+ + R+++ A+
Sbjct: 2328 EAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 411 TECRTGSSHLISTSSWRDGQKLVKKILGPAPRMEPKEQRTASSDRGGRERTAKSGGHIGR 470
+ R + D Q+ K+ A + K RT + + + T I R
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQ----AEEIGEKLHRTELATQ--EKVTLVQTLEIQR 2438
Query: 471 AESDPRLDVLHRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRG 530
+SD + L R ER + K + E + +L S Q+E L
Sbjct: 2439 QQSDHDAERL-REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2497
Query: 531 ILDDLQLDSTAHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVIS---- 586
D L +Q+ +L+ A + +R+ ++ V S
Sbjct: 2498 EKDSLL--QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555
Query: 587 KRRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQE----LYRKQKEAFTK 642
+RR ++ +E VR+++E ++ ++++ Q+E ++N+RL+E L + + A
Sbjct: 2556 RRRQHEAEEG----VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2611
Query: 643 VKNVPPSEPSATRRL 657
+ V S+ +AT+ L
Sbjct: 2612 SEEVTASQVAATKTL 2626
Score = 38.5 bits (88), Expect = 0.10
Identities = 72/383 (18%), Positives = 148/383 (38%), Gaps = 45/383 (11%)
Query: 383 KEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHLISTSSWRDGQ----KLVKKILG 438
+E E ++ + + + ++ +++A+ + R + +++ G+ K +I
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1856
Query: 439 PAPRMEPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERS------- 491
E + R + D + R + +A+ + RL L + ER
Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1916
Query: 492 -RSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVE 550
R + + E I L +S E A K L +E+ I + + T + +Q +E
Sbjct: 1917 LRQRRQVEEEILALKASF------EKAAAGKAELELELGRIRSNAE--DTLRSKEQAELE 1968
Query: 551 LQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRK 610
Q+ A R +R + A E+ +++R +EV + + +E R+ +
Sbjct: 1969 AARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRKAALEEVERLKAKVEEARRLR 2025
Query: 611 QNEEKKAQKE---ATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKL--- 664
+ E+++ ++ A E KRLQ ++ AF V E + LQ+ S L
Sbjct: 2026 ERAEQESARQLQLAQEAAQKRLQA--EEKAHAFA----VQQKEQELQQTLQQEQSVLDQL 2079
Query: 665 ----LLEKTLLEEPSHQHVTQETQAKPGYQPSGESDK-----ENKVQERPPSASSSSDMS 715
+ EE V E +A + E+++ E + Q R A ++++
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-AQAQAAAEKL 2138
Query: 716 LSEPPQPLARKDLMESTWMQPER 738
E Q AR+ E ++ ++
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQ 2161
Score = 33.1 bits (74), Expect = 4.4
Identities = 61/334 (18%), Positives = 124/334 (37%), Gaps = 44/334 (13%)
Query: 389 KSKEKKVVKPVRKVQKVAQLSST-----ECRTGSSHLISTSSWRDGQKLVKKILGPAPRM 443
K++ + V P +K + + S + RT S L + +S + +K I RM
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-----QYIKFISETLRRM 1344
Query: 444 EPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERSRSK--SRSENNI 501
E +E+ RER A+ + E +L H + +ER + R + +
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAAL---EKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 502 KKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVELQNQKSSAPVH 561
+ + D +Q++ + + E++ + + + A + + E + +
Sbjct: 1402 VRREEAAVDAQQQKRS------IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 562 A--------PRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNE 613
R + + + A + KR+ + E + V+ + +RKR+
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 614 EK----KAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKT 669
E KA+ EA +K + LQ L + +A A RRL++ + +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQA-----------EEAERRLRQAEVERARQVQ 1564
Query: 670 LLEEPSHQHVTQETQAKPGYQPSGESDKENKVQE 703
+ E + + E Q+K + E +QE
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598
Score = 32.7 bits (73), Expect = 5.8
Identities = 52/267 (19%), Positives = 107/267 (40%), Gaps = 35/267 (13%)
Query: 2619 SVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKENKDLI-SDATEKV 2677
S +D E L+ E + +Q + +L+ + +V + +E + L S +EK
Sbjct: 2441 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500
Query: 2678 S-------IAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQL 2730
S I E L+ F +E+ K QQ EE+ + + +E+ +L
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ------------MEQERQRL 2548
Query: 2731 EAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLG 2790
A ++ + + ++++ + + ++ + QL+Q ++ ++E + NQ L
Sbjct: 2549 VASMEEARRRQHEAEEGVRR------------KQEELQQLEQQRRQQEELLAEENQR-LR 2595
Query: 2791 DDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDEKEEISSPDMCPRPESPVFGASGQEEL 2850
+ + + Q + + + S + L + ++ + P PE F ++
Sbjct: 2596 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS-FDGLRRKVS 2654
Query: 2851 AKRLAELE-LSREFLSALGDDQDWFDE 2876
A+RL E LS E L L DE
Sbjct: 2655 AQRLQEAGILSAEELQRLAQGHTTVDE 2681
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 91.7 bits (226), Expect = 1e-17
Identities = 219/1114 (19%), Positives = 446/1114 (40%), Gaps = 162/1114 (14%)
Query: 1335 YLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALES 1394
Y+ I E++R++ + ER+ A+QQR E L +++A ALE
Sbjct: 1337 YIKFISETLRRMEEEERL------------------AEQQRAEERERLAEVEA---ALEK 1375
Query: 1395 QRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCK-----IAAQQSETA------- 1442
QRQL A+ HA++ Q + +E+ + +QE + + AQQ + +
Sbjct: 1376 QRQL-------AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1428
Query: 1443 -RLTTDA-----ARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTR- 1495
R +++A ARQ E AE +R I + + L + QR ++ LR R
Sbjct: 1429 LRQSSEAEIQAKARQ-AEAAERSRLRIEEEIRVVRLQLEAT-ERQRGGAEGELQALRARA 1486
Query: 1496 --TETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPS 1553
E ++ + + D +K A + S R E
Sbjct: 1487 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1546
Query: 1554 VPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDES 1613
+ +E E++L ++E + QVQ A + + RS + + + E + + + S
Sbjct: 1547 L-QAEEAERRLRQAEVERA--RQVQVALETAQRSAEA----ELQSKRASFAEKTAQLERS 1599
Query: 1614 MTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQ 1673
+ E+ + R + ++ E+ R + E E+ L + L + +
Sbjct: 1600 LQEEHVAVAQLREEAERRAQQQAEAERAR-----EEAERELERWQLKANEALRLRLQAEE 1654
Query: 1674 DSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGED 1733
+ K + + KEE R A + + E+A++++ ELA E +K+ R E
Sbjct: 1655 VAQQKSLAQAEAEKQKEEAEREARRRG--KAEEQAVRQR---ELAEQELEKQ--RQLAEG 1707
Query: 1734 DKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQE 1793
L +Q + LR + E+ E +R + AR +R+ Q+ +++ K++
Sbjct: 1708 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR-QELEAELAKVRA 1766
Query: 1794 KLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRM 1853
+++ SK + ++++++ S + E ++ ++ ++ ++ K+ R
Sbjct: 1767 EMEVLLASK--ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-- 1822
Query: 1854 DEKFLTKREQKLMQRRQHAEELLEWKRRLDAE------EAEIRQMEKQALAAWDKELIKP 1907
E+ ++R AE +L K E EAEI EK+A + L +
Sbjct: 1823 ------LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1876
Query: 1908 KT-PKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQP 1966
+ ++ LE+Q + K A EE L +SE + Q
Sbjct: 1877 EAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSEL--------------------ERQK 1914
Query: 1967 GSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
G ++ + + +++E K S K+ ++ E G R+ + L K
Sbjct: 1915 G-----LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1969
Query: 2027 HCYSWSDESLSMTQSETTSDQSD-IEGRIRALKDELRKRKSVVNQL-----KKEQKKRQK 2080
+ L+ + + + ++ + A ++ R+RK+ + ++ K E+ +R +
Sbjct: 1970 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2029
Query: 2081 ERLK---------AQEASLIKQLESYDE----FIKKTEAELSQDLETSPTAKPQIKTLSS 2127
ER + AQEA+ K+L++ ++ +++ E EL Q L+ + Q++ +
Sbjct: 2030 ERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2088
Query: 2128 ASEK--PKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSL 2185
A+ + + + E A++ + + E+ER + S E A+ + + +E+ E
Sbjct: 2089 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148
Query: 2186 SAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREES----GDSLENVPALHL-LKELNATSR 2240
A A+R + Q + +K E++ + + L L L+E +
Sbjct: 2149 EA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2207
Query: 2241 ILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVL--LKLVLEQGDSSEIL 2298
+LD E ++ + + E + + E+ FS + + L LK +E + + IL
Sbjct: 2208 LLD-------EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2260
Query: 2299 SKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKE 2358
KD N Q+ L A + +EE + + Q+ + + +D+ +Q+ E
Sbjct: 2261 RDKD------NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAE 2313
Query: 2359 KDLSWSEHLFAPKEIP-YSEDFEVSSFKKEISAE 2391
K L E + A +E + E+ +KE++ E
Sbjct: 2314 KML--KEKMQAVQEATRLKAEAELLQQQKELAQE 2345
Score = 73.6 bits (179), Expect = 3e-12
Identities = 227/1261 (18%), Positives = 480/1261 (38%), Gaps = 182/1261 (14%)
Query: 1339 IEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
I+ RQ ER R + + ++ V Q+ ++QR + L L+A E E+Q+
Sbjct: 1437 IQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK-- 1493
Query: 1399 EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAEL 1458
+ AQ AE L++ VQ + ++ ++A ++A++ A + R + + EL
Sbjct: 1494 -----RQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1545
Query: 1459 TRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSK 1518
R +A RQ + +Q++ ET ++S L QSK + K
Sbjct: 1546 -RLQAEEAE-----------RRLRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAEK 1592
Query: 1519 HQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQ 1578
+ S + R + ++Q++ + + +E E++L +++++ +++
Sbjct: 1593 TAQLERSLQEEHVAVAQL---REEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1649
Query: 1579 TAADDSLRSDSVPSLPDEKDSTSI---------ATEYSLKFDESMTEDEIEEQSFRSLLP 1629
A++ + S+ EK A E +++ E + E E+E+Q R L
Sbjct: 1650 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE-LAEQELEKQ--RQLAE 1706
Query: 1630 SESHRRFNMEKRRGHHDDSDEEASPEKTTLSTA-KELNMPFSGGQDSFSKFTMEM--VRQ 1686
+ +R E+ E+ ++ L L + + E+ VR
Sbjct: 1707 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1766
Query: 1687 YMK---------EEEMRAAHQSSLLRLREKALKEKTKAE----LAWLEHQKKHLRDKGED 1733
M+ EEE R+ + S RL +A + + AE L L + K R E+
Sbjct: 1767 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1826
Query: 1734 DKMPPLRKKQRGLLLRLQQ--EKAEIKRLQEA---NKAARKERQLILKQQEEIEKIRQTT 1788
D + +R L +L E +K E K A ER L + E ++ R
Sbjct: 1827 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1886
Query: 1789 IKLQEK---------LKSAGESKLDSHS---DDDTKDNKATSPGPTDLETRSPSPISISS 1836
Q K L+ A +S+L+ +D + + L+ + ++
Sbjct: 1887 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK----ASFEKAA 1942
Query: 1837 SETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEE-------AEI 1889
+ + + +L ++RS ++ +K + +L RQ E +RR +AEE AE
Sbjct: 1943 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2002
Query: 1890 RQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELG 1949
++ A + E +K K + +R EQ+ + + L +E
Sbjct: 2003 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK------ 2056
Query: 1950 SPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSK 2009
+ + +Q L +E +L ++ + ++ +E+
Sbjct: 2057 --------AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA------EEARV 2102
Query: 2010 GSHRTGGQCHLPIKSHQHC-YSWSDESLSMTQSETTSD------QSDIEGRIRALKDELR 2062
+ R Q ++ + S +++ + Q++ ++ + + R +A + LR
Sbjct: 2103 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2162
Query: 2063 KRKSVVNQLKK-----EQKKRQKERLKAQEASLIKQLES-------YDEFIKKTEAEL-- 2108
++++ +++K EQ RQK +++ + +L QLE DE +++ +AE
Sbjct: 2163 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2222
Query: 2109 -----SQDLETSPTAKPQIKTLSSASEKPKI---------KPLTPLHRSETAKNWKSLTE 2154
SQ E + + Q++ LS + + K T E A+ K + E
Sbjct: 2223 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2282
Query: 2155 -------SERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSP 2207
+ + L +AE A +R+++E+ L + V E + +
Sbjct: 2283 EAARLSVAAQEAARLRQLAEEDLA----QQRALAEKMLKEKMQAVQE----ATRLKAEAE 2334
Query: 2208 VLRSSRKIREESGDSLE---NVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYT 2264
+L+ +++ +E L+ A L +E R L+ + E S ++E ++
Sbjct: 2335 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2394
Query: 2265 KLKKSKI---EDA--FSKEGK--SDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
++ +++ EDA F K+ + + L + L + ++ ++ + + +
Sbjct: 2395 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454
Query: 2318 AIENLHKSEEMLKERQS--DQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPY 2375
AI L + +E L++ +Q + + E + ++ LS + L +
Sbjct: 2455 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2514
Query: 2376 SEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEI 2435
E ++ +L++D+ + L + Q + + + R S + E
Sbjct: 2515 QEKAKLE--------QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2566
Query: 2436 SECLSEKSLSIHSNVHSDRLLE---------LKSPTELMKSKERSDVEHEQQVTESPSLA 2486
E + K + R E L+ +L++ + R+ + H ++VT S A
Sbjct: 2567 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2626
Query: 2487 S 2487
+
Sbjct: 2627 T 2627
Score = 73.6 bits (179), Expect = 3e-12
Identities = 180/910 (19%), Positives = 377/910 (41%), Gaps = 99/910 (10%)
Query: 1341 ESVRQLSDVERVRGISLAQQESV--SLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
E +Q + E R LA++ + +LA+ K Q+Q E D A + +AE+ E +
Sbjct: 1787 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1846
Query: 1399 EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAEL 1458
E + ++ +++R + + ++ + + + A+ D ++ ++ +
Sbjct: 1847 GEATRLKTEAEIALKEKEAENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK- 1904
Query: 1459 TRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTE---TDRKSPSVSLSQSKEGTL 1515
SD+ + L QR+ + + + L+ E + + L + +
Sbjct: 1905 ----ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1960
Query: 1516 DSKHQKYSASYDSYSESSGYKNHDRRSSSGSSR-QESPSVPSCKENEKKLNGEKIE---S 1571
D+ K A ++ + +RR R Q+S + ++K E++E +
Sbjct: 1961 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2020
Query: 1572 SIDEQVQTAADDSLRSDSVPSLPDEKDSTSI-ATEYSLKFDESMTEDEI-----EEQSFR 1625
++E + S L E + A E + F E E+ +EQS
Sbjct: 2021 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2080
Query: 1626 SLLPSESH-RRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMV 1684
L E+ R E+ ++ EA+ + + A+ L S + + ++ +
Sbjct: 2081 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ--SAEEQAQARAQAQAA 2138
Query: 1685 RQYM-KEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQK---KHLRDKGEDDKMPPLR 1740
+ + KE E AA ++ + + AL++K A+ +H+K + LR K +
Sbjct: 2139 AEKLRKEAEQEAARRA---QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ-------- 2187
Query: 1741 KKQRGLLLRLQQEKA---------EIKRLQ-EANKAARKERQLILKQQEEIEKIRQTTIK 1790
+Q LRLQ E+ E++RL+ EA +AAR+ Q+ +EE+ +R +
Sbjct: 2188 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV----EEELFSVRVQMEE 2243
Query: 1791 LQEKLKSAGESK---LDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLK 1847
L KLK+ E++ L D+T+ + +S+++ E + + Q +
Sbjct: 2244 L-SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2302
Query: 1848 K---MRSRMDEKFLTKREQKLMQ--RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDK 1902
+ + + EK L ++ Q + + R + ELL+ ++ L E+A Q +K+ +A
Sbjct: 2303 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2362
Query: 1903 ELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIG 1962
E + + ++ LE +R Q E+++E E + ++ + EE + +E IG
Sbjct: 2363 E--ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK--QAEEIG 2418
Query: 1963 QEQPGSPDHSILTEEMI-CSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLP 2021
++ + + T+E + Q LE S H + ++++ E K + + L
Sbjct: 2419 EKLHRT---ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-LQ 2474
Query: 2022 IKSHQHCYSWSDESLSMTQS---ETTSDQSDIEGRIRALKDELRKRKSV-------VNQL 2071
+KS + ++ L TQ+ S++ + R R ++ E K + + QL
Sbjct: 2475 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2534
Query: 2072 KKEQKKRQ------KERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTL 2125
++EQ+++Q ++RL A ++ +E +++ + EL Q LE + ++
Sbjct: 2535 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-QQLEQQRRQQEELLAE 2593
Query: 2126 SSASEKPKIKPLTPLHRSETAKNWKSLTESE--------RSRGSLESIAEHVDA--SLSG 2175
+ + +++ L HR+ A + + +T S+ R +L+ A + S G
Sbjct: 2594 ENQRLREQLQLLEEQHRAALAHS-EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDG 2652
Query: 2176 SERSVSERSL 2185
R VS + L
Sbjct: 2653 LRRKVSAQRL 2662
Score = 62.8 bits (151), Expect = 5e-09
Identities = 154/835 (18%), Positives = 304/835 (36%), Gaps = 132/835 (15%)
Query: 1136 EDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSSTSSKGK---------KGKKEKTEWLD 1186
E+ R+ A + + ++ + Q A+ K K + ++E L
Sbjct: 1982 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2041
Query: 1187 SFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTD-STLEDLSGHSVSVSS 1245
Q L EEKA + Q K+ ++ +QTL + S L+ L G + +
Sbjct: 2042 LAQEAAQKRLQAEEKAHAFAVQQKE---------QELQQTLQQEQSVLDQLRGEAEAARR 2092
Query: 1246 DKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASR 1305
+++ ++Q Q + A ER K S + A L A +
Sbjct: 2093 AAEEAEEARVQAEREAAQSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148
Query: 1306 TTTENMAPIPGSKRFSPAGLHHRMAAELS---YLNAIEESVRQLSDVER-VRGISLAQQE 1361
+ A L + AA+ + E+++RQ + VE+ + + L +E
Sbjct: 2149 EAARRA-------QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2201
Query: 1362 SVSLAQIIKAQQQR---HERDLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQ 1418
+ ++ + QR + A + + E+E + Q+EE A++ AE+ +++
Sbjct: 2202 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2261
Query: 1419 SQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELTRTHISDAVVASGAPLAILY 1478
+ LQE K+ E ARL+ AA++ + +L ++ A+
Sbjct: 2262 DKDNTQRFLQEEAEKMKQVAEEAARLSV-AAQEAARLRQLAEEDLAQ-------QRALAE 2313
Query: 1479 DHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNH 1538
++ + + R + E + L+Q + L + K + E+ G+
Sbjct: 2314 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL--QEDKEQMAQQLAEETQGF--- 2368
Query: 1539 DRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKD 1598
Q + ++ E E+++ + E + A
Sbjct: 2369 ----------QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR---------------- 2402
Query: 1599 STSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRF--NMEKRRGHHDDSDEEASPEK 1656
A E + +F + +EI E+ R+ L ++ +E +R D E
Sbjct: 2403 ----AEEDAQRFRKQ--AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2456
Query: 1657 TTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLR----LREKALKEK 1712
L KE K E +K EEM+ Q LL+ L++ L EK
Sbjct: 2457 AELEREKE-------------KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2503
Query: 1713 TK--AELAWLEHQKKHLRDKGEDD--KMPPLRKKQRGLLLRLQQEKAE-IKRLQEANKAA 1767
++E +K L +D+ K LR++Q+ +++QE+ + ++EA +
Sbjct: 2504 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2563
Query: 1768 RKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLD--------------SHSDDDTKD 1813
+ + + ++QEE++++ Q + QE+L + +L +HS++ T
Sbjct: 2564 HEAEEGVRRKQEELQQLEQQR-RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2622
Query: 1814 NKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKRE--QKLMQ---- 1867
A + + P + + E S + K R+ E + E Q+L Q
Sbjct: 2623 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTT 2682
Query: 1868 -----RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQ 1917
RR+ L+ + + + + AA ++L+ P T LE Q
Sbjct: 2683 VDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2737
Score = 58.2 bits (139), Expect = 1e-07
Identities = 132/715 (18%), Positives = 300/715 (41%), Gaps = 88/715 (12%)
Query: 1683 MVRQYMK--EEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLR 1740
+ QY+K E +R + L +++A + + AE+ +++ L + K R
Sbjct: 1333 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1392
Query: 1741 KKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTT-IKLQEKLKSAG 1799
+ + L R+Q+E + R +EA A+++++ I QEE++++RQ++ ++Q K + A
Sbjct: 1393 EAKE-LQQRMQEE---VVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQAE 1445
Query: 1800 ESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
++ ++ T+ + R + + + + + +K +++ + + L
Sbjct: 1446 AAERSRLRIEEEIRVVRLQLEATERQ-RGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1504
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRT 1919
++ Q QR++ AE L + + +AE A +Q QAL + + + ++ E +R
Sbjct: 1505 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1564
Query: 1920 EQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMI 1979
Q ++A E ++ S EL S + E+ + S+ E +
Sbjct: 1565 RQVQVALE-----------TAQRSAEAELQSKRASFA-------EKTAQLERSLQEEHVA 1606
Query: 1980 CSQ-ELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSM 2038
+Q E+ + + + +++E + + L +++ + +SL+
Sbjct: 1607 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA---QQKSLAQ 1663
Query: 2039 TQSETTSDQSDIEGRIRALKDE--LRKRKSVVNQLKKEQKKRQ---KERLKAQEASLIKQ 2093
++E ++++ E R R +E +R+R+ +L+K+++ + ++RL A++ + +
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1723
Query: 2094 LESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLT 2153
E+ + E + L A+ Q + ++ ++ +++ R+E
Sbjct: 1724 AET-------EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE--------- 1767
Query: 2154 ESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSR 2213
L S A + S S SE+ S++ L A A R E + + + R
Sbjct: 1768 ----MEVLLASKARAEEESRSTSEK--SKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1821
Query: 2214 KIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSK---KSEI----KEIEYTKL 2266
++ EE ++ R+L +GE+++ ++EI KE E +L
Sbjct: 1822 QLAEEDA-----------ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1870
Query: 2267 KKSKIEDAFSK--------EGKSDVLLKLV-LEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
++ ++AF + + K+D+ +L L + SE+ +K L D+ Q+ V
Sbjct: 1871 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-QRRQVEE 1929
Query: 2318 AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKE 2372
I L S E +++ ++ + +D K E + + L A +E
Sbjct: 1930 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1984
Score = 47.8 bits (112), Expect = 2e-04
Identities = 245/1386 (17%), Positives = 511/1386 (36%), Gaps = 225/1386 (16%)
Query: 1739 LRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLI-----LKQQEEIEKIRQTTIKLQE 1793
LR+ + L QQ E +RL E A K+RQL K Q E E ++ ++QE
Sbjct: 1345 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA-KELQQRMQE 1403
Query: 1794 KLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRM 1853
++ E+ +D+ + ++ L S + I + + + ++ R R+
Sbjct: 1404 EVVRREEAAVDAQ-----QQKRSIQEELQQLRQSSEAEIQAKARQAEAA----ERSRLRI 1454
Query: 1854 DEKFLTKREQKLMQRRQH--AEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPK 1911
+E+ R Q RQ AE L+ R AEEAE ++ + Q A + ++ ++ +
Sbjct: 1455 EEEIRVVRLQLEATERQRGGAEGELQ-ALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513
Query: 1912 K-----ELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEE-LGSPAVEYVPSESIGQEQ 1965
K EL + + E A E++ + L ++ E L VE + E
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE- 1572
Query: 1966 PGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSH 2025
T + EL+S + + S+ ++ + R ++
Sbjct: 1573 ---------TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE--------EAE 1615
Query: 2026 QHCYSWSDESLSMTQSETTSDQSDIEG----RIRALKDELRKRKSVVN---QLKKEQKKR 2078
+ ++ + ++E ++ ++ R+R +E+ ++KS+ + +KE+ +R
Sbjct: 1616 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1675
Query: 2079 QKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLT 2138
+ R E ++Q E ++ ++K + A+ ++ L + +E+ + +
Sbjct: 1676 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ--R 1733
Query: 2139 PLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSR 2198
L E A+ + + + R LE+ V A + E L++ A+ E S
Sbjct: 1734 QLLEEELARLQREAAAATQKRQELEAELAKVRAEM--------EVLLASKARAEEESRST 1785
Query: 2199 TEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEI 2258
+E +S +++ E+G E L E A R L E+ ++ ++
Sbjct: 1786 SE---------KSKQRLEAEAGRFRE-------LAEEAARLRAL------AEEAKRQRQL 1823
Query: 2259 KEIEYTKLKKSKIEDAFSKEGKSD-VLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
E EDA + +++ VL + + G+++ + ++ ++ L + + +
Sbjct: 1824 AE-----------EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE---- 1868
Query: 2318 AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSE 2377
+ L + E + R +Q H DI E+
Sbjct: 1869 RLRRLAEDEAFQRRRLEEQAAQHKA------DIEER------------------------ 1898
Query: 2378 DFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNE---E 2434
++ +K +EL + V L R+ + ++ +++S A + G E E
Sbjct: 1899 ---LAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKASFEKAAA-GKAELELE 1951
Query: 2435 ISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESPSLASVPTADEL 2494
+ S ++ S ++ LE +L +ER E E++V +S +
Sbjct: 1952 LGRIRSNAEDTLRSKEQAE--LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2009
Query: 2495 FDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKH 2554
+R+ + LR + E A+ E + + +EK
Sbjct: 2010 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR------------LQAEEKA 2057
Query: 2555 GIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYE 2614
FA QK E Q QEQ+ + + E + + E
Sbjct: 2058 HAFAVQQK---------------------EQELQQTLQQEQSVLDQLRG-EAEAARRAAE 2095
Query: 2615 KSLPSVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKE-NKDLISDA 2673
++ + E +SR E + ++ A Q+ +Q ++++ K+ +A
Sbjct: 2096 EAEEARVQAEREAAQSRRQVEEAERLKQ-----SAEEQAQARAQAQAAAEKLRKEAEQEA 2150
Query: 2674 TEKVSIAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLL---------DLLT 2724
+ E+EK ++F E+ A+ ++L T L +LL
Sbjct: 2151 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2210
Query: 2725 REKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLS 2784
E +L+A+ + + + +++L + + + L K+ + I + +D +
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2270
Query: 2785 NQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDE--------KEEISSPDMCPR 2836
+E + K+V + +V Q + +L + KE++ + R
Sbjct: 2271 QEE--AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328
Query: 2837 PESPVFGASGQEELAKRLA-ELELSREFLSALGDDQDWFDEDFGLSSSHKIQKNKAEETI 2895
++ Q+ELA+ A L+ +E ++ Q +E G + + ++ + E
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMA-----QQLAEETQGFQRTLEAERQRQLE-- 2381
Query: 2896 VPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKELGHDLHSISIPTKLLG 2955
+ AE +R+ + E A E+ + A +E+G LH + T+
Sbjct: 2382 --MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLHRTELATQEKV 2432
Query: 2956 CASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMKPCRINSSYFRRVKNP 3015
+ L+I+ R + +E E+ E L Q K ++ S + V+
Sbjct: 2433 TLVQTLEIQ----RQQSDHDAERLREAIAELEREKEKLQQEA--KLLQLKSEEMQTVQQE 2486
Query: 3016 NNLDEIKSFIASEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVDHILVQELHEEEAQWV 3075
L E ++ S + + SL + + Q+ K + +D V Q+L EE+ +
Sbjct: 2487 QLLQETQALQQSFLSEKDSLLQ--RERFIEQEKAKLEQLFQDEV--AKAQQLREEQQRQQ 2542
Query: 3076 NYDEDE 3081
E E
Sbjct: 2543 QQMEQE 2548
Score = 47.4 bits (111), Expect = 2e-04
Identities = 109/504 (21%), Positives = 195/504 (38%), Gaps = 71/504 (14%)
Query: 1749 RLQQEKAEIKRLQEANKAA---RKERQLILKQQEEIEKI------RQTTIKLQEKLKSAG 1799
RL E ++ L E + AA R E +L L + E++ + + TI L +
Sbjct: 1046 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1105
Query: 1800 ESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
E L +H ++ K+ +A +LE T + ++KL+ F
Sbjct: 1106 EEVLRAH-EEQLKEAQAVPATLPELEA------------TKASLKKLRAQAEAQQPTFDA 1152
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRT 1919
R++ L ++ E L + D E R+ Q L W L + ++ELE
Sbjct: 1153 LRDE-LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQL-- 1209
Query: 1920 EQKEIASEEESPVPLYSHLNSESSIPEELGSP--AVEYVPSESIGQEQPGSPD---HSIL 1974
+++ ES PL + L E++ + A E + QEQ + H
Sbjct: 1210 -GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1268
Query: 1975 TEE--------MICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
EE + ++ E K L + K + GS Q ++ +++H
Sbjct: 1269 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTH- 1326
Query: 2027 HCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQ 2086
SE T+ S I+ + + LR R +L ++Q+ ++ERL
Sbjct: 1327 -------------YSELTTLTSQY---IKFISETLR-RMEEEERLAEQQRAEERERLAEV 1369
Query: 2087 EASLIKQLESYDEFIK-KTEA-----ELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPL 2140
EA+L KQ + + + K +A EL Q ++ + + + ++ + L L
Sbjct: 1370 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1429
Query: 2141 HRSETAK---NWKSLTESERSRGSLESIAEHVDASLSGSE--RSVSERSLSAYAKRVNEW 2195
+S A+ + +ERSR +E V L +E R +E L A R E
Sbjct: 1430 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1489
Query: 2196 DSRTEDFQTPSPVLRSSRKIREES 2219
+++ Q + LR R++++ES
Sbjct: 1490 EAQKRQAQEEAERLR--RQVQDES 1511
Score = 39.7 bits (91), Expect = 0.047
Identities = 64/315 (20%), Positives = 125/315 (39%), Gaps = 31/315 (9%)
Query: 358 EAEFQNMSRELYRDLALHFADDISIKEKPAEKSKEKKV-------VKPVRKVQKVAQLSS 410
EAE +EL ++ A +D KE+ A++ E+ + R+++ A+
Sbjct: 2332 EAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388
Query: 411 TECRTGSSHLISTSSWRDGQKLVKKILGPAPRMEPKEQRTASSDRGGRERTAKSGGHIGR 470
+ R + D Q+ K+ A + K RT + + + T I R
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQ----AEEIGEKLHRTELATQ--EKVTLVQTLEIQR 2442
Query: 471 AESDPRLDVLHRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRG 530
+SD + L R ER + K + E + +L S Q+E L
Sbjct: 2443 QQSDHDAERL-REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2501
Query: 531 ILDDLQLDSTAHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVIS---- 586
D L +Q+ +L+ A + +R+ ++ V S
Sbjct: 2502 EKDSLL--QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2559
Query: 587 KRRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQE----LYRKQKEAFTK 642
+RR ++ +E VR+++E ++ ++++ Q+E ++N+RL+E L + + A
Sbjct: 2560 RRRQHEAEEG----VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2615
Query: 643 VKNVPPSEPSATRRL 657
+ V S+ +AT+ L
Sbjct: 2616 SEEVTASQVAATKTL 2630
Score = 38.5 bits (88), Expect = 0.10
Identities = 72/383 (18%), Positives = 148/383 (38%), Gaps = 45/383 (11%)
Query: 383 KEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHLISTSSWRDGQ----KLVKKILG 438
+E E ++ + + + ++ +++A+ + R + +++ G+ K +I
Sbjct: 1801 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1860
Query: 439 PAPRMEPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERS------- 491
E + R + D + R + +A+ + RL L + ER
Sbjct: 1861 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1920
Query: 492 -RSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVE 550
R + + E I L +S E A K L +E+ I + + T + +Q +E
Sbjct: 1921 LRQRRQVEEEILALKASF------EKAAAGKAELELELGRIRSNAE--DTLRSKEQAELE 1972
Query: 551 LQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRK 610
Q+ A R +R + A E+ +++R +EV + + +E R+ +
Sbjct: 1973 AARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRKAALEEVERLKAKVEEARRLR 2029
Query: 611 QNEEKKAQKE---ATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKL--- 664
+ E+++ ++ A E KRLQ ++ AF V E + LQ+ S L
Sbjct: 2030 ERAEQESARQLQLAQEAAQKRLQA--EEKAHAFA----VQQKEQELQQTLQQEQSVLDQL 2083
Query: 665 ----LLEKTLLEEPSHQHVTQETQAKPGYQPSGESDK-----ENKVQERPPSASSSSDMS 715
+ EE V E +A + E+++ E + Q R A ++++
Sbjct: 2084 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-AQAQAAAEKL 2142
Query: 716 LSEPPQPLARKDLMESTWMQPER 738
E Q AR+ E ++ ++
Sbjct: 2143 RKEAEQEAARRAQAEQAALRQKQ 2165
Score = 33.1 bits (74), Expect = 4.4
Identities = 61/334 (18%), Positives = 124/334 (37%), Gaps = 44/334 (13%)
Query: 389 KSKEKKVVKPVRKVQKVAQLSST-----ECRTGSSHLISTSSWRDGQKLVKKILGPAPRM 443
K++ + V P +K + + S + RT S L + +S + +K I RM
Sbjct: 1294 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-----QYIKFISETLRRM 1348
Query: 444 EPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERSRSK--SRSENNI 501
E +E+ RER A+ + E +L H + +ER + R + +
Sbjct: 1349 EEEERLAEQQRAEERERLAEVEAAL---EKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1405
Query: 502 KKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVELQNQKSSAPVH 561
+ + D +Q++ + + E++ + + + A + + E + +
Sbjct: 1406 VRREEAAVDAQQQKRS------IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1459
Query: 562 A--------PRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNE 613
R + + + A + KR+ + E + V+ + +RKR+
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1519
Query: 614 EK----KAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKT 669
E KA+ EA +K + LQ L + +A A RRL++ + +
Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQA-----------EEAERRLRQAEVERARQVQ 1568
Query: 670 LLEEPSHQHVTQETQAKPGYQPSGESDKENKVQE 703
+ E + + E Q+K + E +QE
Sbjct: 1569 VALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1602
Score = 32.7 bits (73), Expect = 5.8
Identities = 52/267 (19%), Positives = 107/267 (40%), Gaps = 35/267 (13%)
Query: 2619 SVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKENKDLI-SDATEKV 2677
S +D E L+ E + +Q + +L+ + +V + +E + L S +EK
Sbjct: 2445 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2504
Query: 2678 S-------IAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQL 2730
S I E L+ F +E+ K QQ EE+ + + +E+ +L
Sbjct: 2505 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ------------MEQERQRL 2552
Query: 2731 EAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLG 2790
A ++ + + ++++ + + ++ + QL+Q ++ ++E + NQ L
Sbjct: 2553 VASMEEARRRQHEAEEGVRR------------KQEELQQLEQQRRQQEELLAEENQR-LR 2599
Query: 2791 DDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDEKEEISSPDMCPRPESPVFGASGQEEL 2850
+ + + Q + + + S + L + ++ + P PE F ++
Sbjct: 2600 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS-FDGLRRKVS 2658
Query: 2851 AKRLAELE-LSREFLSALGDDQDWFDE 2876
A+RL E LS E L L DE
Sbjct: 2659 AQRLQEAGILSAEELQRLAQGHTTVDE 2685
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 91.7 bits (226), Expect = 1e-17
Identities = 219/1114 (19%), Positives = 446/1114 (40%), Gaps = 162/1114 (14%)
Query: 1335 YLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALES 1394
Y+ I E++R++ + ER+ A+QQR E L +++A ALE
Sbjct: 1333 YIKFISETLRRMEEEERL------------------AEQQRAEERERLAEVEA---ALEK 1371
Query: 1395 QRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCK-----IAAQQSETA------- 1442
QRQL A+ HA++ Q + +E+ + +QE + + AQQ + +
Sbjct: 1372 QRQL-------AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1424
Query: 1443 -RLTTDA-----ARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTR- 1495
R +++A ARQ E AE +R I + + L + QR ++ LR R
Sbjct: 1425 LRQSSEAEIQAKARQ-AEAAERSRLRIEEEIRVVRLQLEAT-ERQRGGAEGELQALRARA 1482
Query: 1496 --TETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPS 1553
E ++ + + D +K A + S R E
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1542
Query: 1554 VPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDES 1613
+ +E E++L ++E + QVQ A + + RS + + + E + + + S
Sbjct: 1543 L-QAEEAERRLRQAEVERA--RQVQVALETAQRSAEA----ELQSKRASFAEKTAQLERS 1595
Query: 1614 MTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQ 1673
+ E+ + R + ++ E+ R + E E+ L + L + +
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAR-----EEAERELERWQLKANEALRLRLQAEE 1650
Query: 1674 DSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGED 1733
+ K + + KEE R A + + E+A++++ ELA E +K+ R E
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRG--KAEEQAVRQR---ELAEQELEKQ--RQLAEG 1703
Query: 1734 DKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQE 1793
L +Q + LR + E+ E +R + AR +R+ Q+ +++ K++
Sbjct: 1704 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR-QELEAELAKVRA 1762
Query: 1794 KLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRM 1853
+++ SK + ++++++ S + E ++ ++ ++ ++ K+ R
Sbjct: 1763 EMEVLLASK--ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-- 1818
Query: 1854 DEKFLTKREQKLMQRRQHAEELLEWKRRLDAE------EAEIRQMEKQALAAWDKELIKP 1907
E+ ++R AE +L K E EAEI EK+A + L +
Sbjct: 1819 ------LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Query: 1908 KT-PKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQP 1966
+ ++ LE+Q + K A EE L +SE + Q
Sbjct: 1873 EAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSEL--------------------ERQK 1910
Query: 1967 GSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
G ++ + + +++E K S K+ ++ E G R+ + L K
Sbjct: 1911 G-----LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1965
Query: 2027 HCYSWSDESLSMTQSETTSDQSD-IEGRIRALKDELRKRKSVVNQL-----KKEQKKRQK 2080
+ L+ + + + ++ + A ++ R+RK+ + ++ K E+ +R +
Sbjct: 1966 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2025
Query: 2081 ERLK---------AQEASLIKQLESYDE----FIKKTEAELSQDLETSPTAKPQIKTLSS 2127
ER + AQEA+ K+L++ ++ +++ E EL Q L+ + Q++ +
Sbjct: 2026 ERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084
Query: 2128 ASEK--PKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSL 2185
A+ + + + E A++ + + E+ER + S E A+ + + +E+ E
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 2186 SAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREES----GDSLENVPALHL-LKELNATSR 2240
A A+R + Q + +K E++ + + L L L+E +
Sbjct: 2145 EA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2203
Query: 2241 ILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVL--LKLVLEQGDSSEIL 2298
+LD E ++ + + E + + E+ FS + + L LK +E + + IL
Sbjct: 2204 LLD-------EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256
Query: 2299 SKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKE 2358
KD N Q+ L A + +EE + + Q+ + + +D+ +Q+ E
Sbjct: 2257 RDKD------NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAE 2309
Query: 2359 KDLSWSEHLFAPKEIP-YSEDFEVSSFKKEISAE 2391
K L E + A +E + E+ +KE++ E
Sbjct: 2310 KML--KEKMQAVQEATRLKAEAELLQQQKELAQE 2341
Score = 73.6 bits (179), Expect = 3e-12
Identities = 227/1261 (18%), Positives = 480/1261 (38%), Gaps = 182/1261 (14%)
Query: 1339 IEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
I+ RQ ER R + + ++ V Q+ ++QR + L L+A E E+Q+
Sbjct: 1433 IQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK-- 1489
Query: 1399 EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAEL 1458
+ AQ AE L++ VQ + ++ ++A ++A++ A + R + + EL
Sbjct: 1490 -----RQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1541
Query: 1459 TRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSK 1518
R +A RQ + +Q++ ET ++S L QSK + K
Sbjct: 1542 -RLQAEEAE-----------RRLRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAEK 1588
Query: 1519 HQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQ 1578
+ S + R + ++Q++ + + +E E++L +++++ +++
Sbjct: 1589 TAQLERSLQEEHVAVAQL---REEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 1579 TAADDSLRSDSVPSLPDEKDSTSI---------ATEYSLKFDESMTEDEIEEQSFRSLLP 1629
A++ + S+ EK A E +++ E + E E+E+Q R L
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE-LAEQELEKQ--RQLAE 1702
Query: 1630 SESHRRFNMEKRRGHHDDSDEEASPEKTTLSTA-KELNMPFSGGQDSFSKFTMEM--VRQ 1686
+ +R E+ E+ ++ L L + + E+ VR
Sbjct: 1703 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1762
Query: 1687 YMK---------EEEMRAAHQSSLLRLREKALKEKTKAE----LAWLEHQKKHLRDKGED 1733
M+ EEE R+ + S RL +A + + AE L L + K R E+
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 1734 DKMPPLRKKQRGLLLRLQQ--EKAEIKRLQEA---NKAARKERQLILKQQEEIEKIRQTT 1788
D + +R L +L E +K E K A ER L + E ++ R
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882
Query: 1789 IKLQEK---------LKSAGESKLDSHS---DDDTKDNKATSPGPTDLETRSPSPISISS 1836
Q K L+ A +S+L+ +D + + L+ + ++
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK----ASFEKAA 1938
Query: 1837 SETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEE-------AEI 1889
+ + + +L ++RS ++ +K + +L RQ E +RR +AEE AE
Sbjct: 1939 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1998
Query: 1890 RQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELG 1949
++ A + E +K K + +R EQ+ + + L +E
Sbjct: 1999 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK------ 2052
Query: 1950 SPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSK 2009
+ + +Q L +E +L ++ + ++ +E+
Sbjct: 2053 --------AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA------EEARV 2098
Query: 2010 GSHRTGGQCHLPIKSHQHC-YSWSDESLSMTQSETTSD------QSDIEGRIRALKDELR 2062
+ R Q ++ + S +++ + Q++ ++ + + R +A + LR
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2158
Query: 2063 KRKSVVNQLKK-----EQKKRQKERLKAQEASLIKQLES-------YDEFIKKTEAEL-- 2108
++++ +++K EQ RQK +++ + +L QLE DE +++ +AE
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218
Query: 2109 -----SQDLETSPTAKPQIKTLSSASEKPKI---------KPLTPLHRSETAKNWKSLTE 2154
SQ E + + Q++ LS + + K T E A+ K + E
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278
Query: 2155 -------SERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSP 2207
+ + L +AE A +R+++E+ L + V E + +
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLA----QQRALAEKMLKEKMQAVQE----ATRLKAEAE 2330
Query: 2208 VLRSSRKIREESGDSLE---NVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYT 2264
+L+ +++ +E L+ A L +E R L+ + E S ++E ++
Sbjct: 2331 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390
Query: 2265 KLKKSKI---EDA--FSKEGK--SDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
++ +++ EDA F K+ + + L + L + ++ ++ + + +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 2318 AIENLHKSEEMLKERQS--DQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPY 2375
AI L + +E L++ +Q + + E + ++ LS + L +
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510
Query: 2376 SEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEI 2435
E ++ +L++D+ + L + Q + + + R S + E
Sbjct: 2511 QEKAKLE--------QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562
Query: 2436 SECLSEKSLSIHSNVHSDRLLE---------LKSPTELMKSKERSDVEHEQQVTESPSLA 2486
E + K + R E L+ +L++ + R+ + H ++VT S A
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2622
Query: 2487 S 2487
+
Sbjct: 2623 T 2623
Score = 73.6 bits (179), Expect = 3e-12
Identities = 180/910 (19%), Positives = 377/910 (41%), Gaps = 99/910 (10%)
Query: 1341 ESVRQLSDVERVRGISLAQQESV--SLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
E +Q + E R LA++ + +LA+ K Q+Q E D A + +AE+ E +
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842
Query: 1399 EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAEL 1458
E + ++ +++R + + ++ + + + A+ D ++ ++ +
Sbjct: 1843 GEATRLKTEAEIALKEKEAENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK- 1900
Query: 1459 TRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTE---TDRKSPSVSLSQSKEGTL 1515
SD+ + L QR+ + + + L+ E + + L + +
Sbjct: 1901 ----ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1956
Query: 1516 DSKHQKYSASYDSYSESSGYKNHDRRSSSGSSR-QESPSVPSCKENEKKLNGEKIE---S 1571
D+ K A ++ + +RR R Q+S + ++K E++E +
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016
Query: 1572 SIDEQVQTAADDSLRSDSVPSLPDEKDSTSI-ATEYSLKFDESMTEDEI-----EEQSFR 1625
++E + S L E + A E + F E E+ +EQS
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076
Query: 1626 SLLPSESH-RRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMV 1684
L E+ R E+ ++ EA+ + + A+ L S + + ++ +
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ--SAEEQAQARAQAQAA 2134
Query: 1685 RQYM-KEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQK---KHLRDKGEDDKMPPLR 1740
+ + KE E AA ++ + + AL++K A+ +H+K + LR K +
Sbjct: 2135 AEKLRKEAEQEAARRA---QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ-------- 2183
Query: 1741 KKQRGLLLRLQQEKA---------EIKRLQ-EANKAARKERQLILKQQEEIEKIRQTTIK 1790
+Q LRLQ E+ E++RL+ EA +AAR+ Q+ +EE+ +R +
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV----EEELFSVRVQMEE 2239
Query: 1791 LQEKLKSAGESK---LDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLK 1847
L KLK+ E++ L D+T+ + +S+++ E + + Q +
Sbjct: 2240 L-SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2298
Query: 1848 K---MRSRMDEKFLTKREQKLMQ--RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDK 1902
+ + + EK L ++ Q + + R + ELL+ ++ L E+A Q +K+ +A
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358
Query: 1903 ELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIG 1962
E + + ++ LE +R Q E+++E E + ++ + EE + +E IG
Sbjct: 2359 E--ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK--QAEEIG 2414
Query: 1963 QEQPGSPDHSILTEEMI-CSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLP 2021
++ + + T+E + Q LE S H + ++++ E K + + L
Sbjct: 2415 EKLHRT---ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-LQ 2470
Query: 2022 IKSHQHCYSWSDESLSMTQS---ETTSDQSDIEGRIRALKDELRKRKSV-------VNQL 2071
+KS + ++ L TQ+ S++ + R R ++ E K + + QL
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530
Query: 2072 KKEQKKRQ------KERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTL 2125
++EQ+++Q ++RL A ++ +E +++ + EL Q LE + ++
Sbjct: 2531 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-QQLEQQRRQQEELLAE 2589
Query: 2126 SSASEKPKIKPLTPLHRSETAKNWKSLTESE--------RSRGSLESIAEHVDA--SLSG 2175
+ + +++ L HR+ A + + +T S+ R +L+ A + S G
Sbjct: 2590 ENQRLREQLQLLEEQHRAALAHS-EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDG 2648
Query: 2176 SERSVSERSL 2185
R VS + L
Sbjct: 2649 LRRKVSAQRL 2658
Score = 62.8 bits (151), Expect = 5e-09
Identities = 154/835 (18%), Positives = 304/835 (36%), Gaps = 132/835 (15%)
Query: 1136 EDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSSTSSKGK---------KGKKEKTEWLD 1186
E+ R+ A + + ++ + Q A+ K K + ++E L
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037
Query: 1187 SFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTD-STLEDLSGHSVSVSS 1245
Q L EEKA + Q K+ ++ +QTL + S L+ L G + +
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKE---------QELQQTLQQEQSVLDQLRGEAEAARR 2088
Query: 1246 DKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASR 1305
+++ ++Q Q + A ER K S + A L A +
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 1306 TTTENMAPIPGSKRFSPAGLHHRMAAELS---YLNAIEESVRQLSDVER-VRGISLAQQE 1361
+ A L + AA+ + E+++RQ + VE+ + + L +E
Sbjct: 2145 EAARRA-------QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 1362 SVSLAQIIKAQQQR---HERDLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQ 1418
+ ++ + QR + A + + E+E + Q+EE A++ AE+ +++
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2257
Query: 1419 SQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELTRTHISDAVVASGAPLAILY 1478
+ LQE K+ E ARL+ AA++ + +L ++ A+
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSV-AAQEAARLRQLAEEDLAQ-------QRALAE 2309
Query: 1479 DHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNH 1538
++ + + R + E + L+Q + L + K + E+ G+
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL--QEDKEQMAQQLAEETQGF--- 2364
Query: 1539 DRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKD 1598
Q + ++ E E+++ + E + A
Sbjct: 2365 ----------QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR---------------- 2398
Query: 1599 STSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRF--NMEKRRGHHDDSDEEASPEK 1656
A E + +F + +EI E+ R+ L ++ +E +R D E
Sbjct: 2399 ----AEEDAQRFRKQ--AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452
Query: 1657 TTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLR----LREKALKEK 1712
L KE K E +K EEM+ Q LL+ L++ L EK
Sbjct: 2453 AELEREKE-------------KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2499
Query: 1713 TK--AELAWLEHQKKHLRDKGEDD--KMPPLRKKQRGLLLRLQQEKAE-IKRLQEANKAA 1767
++E +K L +D+ K LR++Q+ +++QE+ + ++EA +
Sbjct: 2500 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2559
Query: 1768 RKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLD--------------SHSDDDTKD 1813
+ + + ++QEE++++ Q + QE+L + +L +HS++ T
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQR-RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2618
Query: 1814 NKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKRE--QKLMQ---- 1867
A + + P + + E S + K R+ E + E Q+L Q
Sbjct: 2619 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTT 2678
Query: 1868 -----RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQ 1917
RR+ L+ + + + + AA ++L+ P T LE Q
Sbjct: 2679 VDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2733
Score = 58.2 bits (139), Expect = 1e-07
Identities = 132/715 (18%), Positives = 300/715 (41%), Gaps = 88/715 (12%)
Query: 1683 MVRQYMK--EEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLR 1740
+ QY+K E +R + L +++A + + AE+ +++ L + K R
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388
Query: 1741 KKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTT-IKLQEKLKSAG 1799
+ + L R+Q+E + R +EA A+++++ I QEE++++RQ++ ++Q K + A
Sbjct: 1389 EAKE-LQQRMQEE---VVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQAE 1441
Query: 1800 ESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
++ ++ T+ + R + + + + + +K +++ + + L
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQ-RGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1500
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRT 1919
++ Q QR++ AE L + + +AE A +Q QAL + + + ++ E +R
Sbjct: 1501 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1560
Query: 1920 EQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMI 1979
Q ++A E ++ S EL S + E+ + S+ E +
Sbjct: 1561 RQVQVALE-----------TAQRSAEAELQSKRASFA-------EKTAQLERSLQEEHVA 1602
Query: 1980 CSQ-ELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSM 2038
+Q E+ + + + +++E + + L +++ + +SL+
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA---QQKSLAQ 1659
Query: 2039 TQSETTSDQSDIEGRIRALKDE--LRKRKSVVNQLKKEQKKRQ---KERLKAQEASLIKQ 2093
++E ++++ E R R +E +R+R+ +L+K+++ + ++RL A++ + +
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719
Query: 2094 LESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLT 2153
E+ + E + L A+ Q + ++ ++ +++ R+E
Sbjct: 1720 AET-------EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE--------- 1763
Query: 2154 ESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSR 2213
L S A + S S SE+ S++ L A A R E + + + R
Sbjct: 1764 ----MEVLLASKARAEEESRSTSEK--SKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817
Query: 2214 KIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSK---KSEI----KEIEYTKL 2266
++ EE ++ R+L +GE+++ ++EI KE E +L
Sbjct: 1818 QLAEEDA-----------ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866
Query: 2267 KKSKIEDAFSK--------EGKSDVLLKLV-LEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
++ ++AF + + K+D+ +L L + SE+ +K L D+ Q+ V
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-QRRQVEE 1925
Query: 2318 AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKE 2372
I L S E +++ ++ + +D K E + + L A +E
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980
Score = 47.8 bits (112), Expect = 2e-04
Identities = 245/1386 (17%), Positives = 511/1386 (36%), Gaps = 225/1386 (16%)
Query: 1739 LRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLI-----LKQQEEIEKIRQTTIKLQE 1793
LR+ + L QQ E +RL E A K+RQL K Q E E ++ ++QE
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA-KELQQRMQE 1399
Query: 1794 KLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRM 1853
++ E+ +D+ + ++ L S + I + + + ++ R R+
Sbjct: 1400 EVVRREEAAVDAQ-----QQKRSIQEELQQLRQSSEAEIQAKARQAEAA----ERSRLRI 1450
Query: 1854 DEKFLTKREQKLMQRRQH--AEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPK 1911
+E+ R Q RQ AE L+ R AEEAE ++ + Q A + ++ ++ +
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQ-ALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
Query: 1912 K-----ELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEE-LGSPAVEYVPSESIGQEQ 1965
K EL + + E A E++ + L ++ E L VE + E
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE- 1568
Query: 1966 PGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSH 2025
T + EL+S + + S+ ++ + R ++
Sbjct: 1569 ---------TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE--------EAE 1611
Query: 2026 QHCYSWSDESLSMTQSETTSDQSDIEG----RIRALKDELRKRKSVVN---QLKKEQKKR 2078
+ ++ + ++E ++ ++ R+R +E+ ++KS+ + +KE+ +R
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 2079 QKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLT 2138
+ R E ++Q E ++ ++K + A+ ++ L + +E+ + +
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ--R 1729
Query: 2139 PLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSR 2198
L E A+ + + + R LE+ V A + E L++ A+ E S
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEM--------EVLLASKARAEEESRST 1781
Query: 2199 TEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEI 2258
+E +S +++ E+G E L E A R L E+ ++ ++
Sbjct: 1782 SE---------KSKQRLEAEAGRFRE-------LAEEAARLRAL------AEEAKRQRQL 1819
Query: 2259 KEIEYTKLKKSKIEDAFSKEGKSD-VLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
E EDA + +++ VL + + G+++ + ++ ++ L + + +
Sbjct: 1820 AE-----------EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE---- 1864
Query: 2318 AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSE 2377
+ L + E + R +Q H DI E+
Sbjct: 1865 RLRRLAEDEAFQRRRLEEQAAQHKA------DIEER------------------------ 1894
Query: 2378 DFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNE---E 2434
++ +K +EL + V L R+ + ++ +++S A + G E E
Sbjct: 1895 ---LAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKASFEKAAA-GKAELELE 1947
Query: 2435 ISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESPSLASVPTADEL 2494
+ S ++ S ++ LE +L +ER E E++V +S +
Sbjct: 1948 LGRIRSNAEDTLRSKEQAE--LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005
Query: 2495 FDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKH 2554
+R+ + LR + E A+ E + + +EK
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR------------LQAEEKA 2053
Query: 2555 GIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYE 2614
FA QK E Q QEQ+ + + E + + E
Sbjct: 2054 HAFAVQQK---------------------EQELQQTLQQEQSVLDQLRG-EAEAARRAAE 2091
Query: 2615 KSLPSVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKE-NKDLISDA 2673
++ + E +SR E + ++ A Q+ +Q ++++ K+ +A
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEEAERLKQ-----SAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 2674 TEKVSIAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLL---------DLLT 2724
+ E+EK ++F E+ A+ ++L T L +LL
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 2725 REKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLS 2784
E +L+A+ + + + +++L + + + L K+ + I + +D +
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266
Query: 2785 NQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDE--------KEEISSPDMCPR 2836
+E + K+V + +V Q + +L + KE++ + R
Sbjct: 2267 QEE--AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 2837 PESPVFGASGQEELAKRLA-ELELSREFLSALGDDQDWFDEDFGLSSSHKIQKNKAEETI 2895
++ Q+ELA+ A L+ +E ++ Q +E G + + ++ + E
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMA-----QQLAEETQGFQRTLEAERQRQLE-- 2377
Query: 2896 VPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKELGHDLHSISIPTKLLG 2955
+ AE +R+ + E A E+ + A +E+G LH + T+
Sbjct: 2378 --MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLHRTELATQEKV 2428
Query: 2956 CASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMKPCRINSSYFRRVKNP 3015
+ L+I+ R + +E E+ E L Q K ++ S + V+
Sbjct: 2429 TLVQTLEIQ----RQQSDHDAERLREAIAELEREKEKLQQEA--KLLQLKSEEMQTVQQE 2482
Query: 3016 NNLDEIKSFIASEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVDHILVQELHEEEAQWV 3075
L E ++ S + + SL + + Q+ K + +D V Q+L EE+ +
Sbjct: 2483 QLLQETQALQQSFLSEKDSLLQ--RERFIEQEKAKLEQLFQDEV--AKAQQLREEQQRQQ 2538
Query: 3076 NYDEDE 3081
E E
Sbjct: 2539 QQMEQE 2544
Score = 47.4 bits (111), Expect = 2e-04
Identities = 109/504 (21%), Positives = 195/504 (38%), Gaps = 71/504 (14%)
Query: 1749 RLQQEKAEIKRLQEANKAA---RKERQLILKQQEEIEKI------RQTTIKLQEKLKSAG 1799
RL E ++ L E + AA R E +L L + E++ + + TI L +
Sbjct: 1042 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1101
Query: 1800 ESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
E L +H ++ K+ +A +LE T + ++KL+ F
Sbjct: 1102 EEVLRAH-EEQLKEAQAVPATLPELEA------------TKASLKKLRAQAEAQQPTFDA 1148
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRT 1919
R++ L ++ E L + D E R+ Q L W L + ++ELE
Sbjct: 1149 LRDE-LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQL-- 1205
Query: 1920 EQKEIASEEESPVPLYSHLNSESSIPEELGSP--AVEYVPSESIGQEQPGSPD---HSIL 1974
+++ ES PL + L E++ + A E + QEQ + H
Sbjct: 1206 -GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264
Query: 1975 TEE--------MICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
EE + ++ E K L + K + GS Q ++ +++H
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTH- 1322
Query: 2027 HCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQ 2086
SE T+ S I+ + + LR R +L ++Q+ ++ERL
Sbjct: 1323 -------------YSELTTLTSQY---IKFISETLR-RMEEEERLAEQQRAEERERLAEV 1365
Query: 2087 EASLIKQLESYDEFIK-KTEA-----ELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPL 2140
EA+L KQ + + + K +A EL Q ++ + + + ++ + L L
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 2141 HRSETAK---NWKSLTESERSRGSLESIAEHVDASLSGSE--RSVSERSLSAYAKRVNEW 2195
+S A+ + +ERSR +E V L +E R +E L A R E
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485
Query: 2196 DSRTEDFQTPSPVLRSSRKIREES 2219
+++ Q + LR R++++ES
Sbjct: 1486 EAQKRQAQEEAERLR--RQVQDES 1507
Score = 39.7 bits (91), Expect = 0.047
Identities = 64/315 (20%), Positives = 125/315 (39%), Gaps = 31/315 (9%)
Query: 358 EAEFQNMSRELYRDLALHFADDISIKEKPAEKSKEKKV-------VKPVRKVQKVAQLSS 410
EAE +EL ++ A +D KE+ A++ E+ + R+++ A+
Sbjct: 2328 EAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 411 TECRTGSSHLISTSSWRDGQKLVKKILGPAPRMEPKEQRTASSDRGGRERTAKSGGHIGR 470
+ R + D Q+ K+ A + K RT + + + T I R
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQ----AEEIGEKLHRTELATQ--EKVTLVQTLEIQR 2438
Query: 471 AESDPRLDVLHRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRG 530
+SD + L R ER + K + E + +L S Q+E L
Sbjct: 2439 QQSDHDAERL-REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2497
Query: 531 ILDDLQLDSTAHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVIS---- 586
D L +Q+ +L+ A + +R+ ++ V S
Sbjct: 2498 EKDSLL--QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555
Query: 587 KRRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQE----LYRKQKEAFTK 642
+RR ++ +E VR+++E ++ ++++ Q+E ++N+RL+E L + + A
Sbjct: 2556 RRRQHEAEEG----VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2611
Query: 643 VKNVPPSEPSATRRL 657
+ V S+ +AT+ L
Sbjct: 2612 SEEVTASQVAATKTL 2626
Score = 38.5 bits (88), Expect = 0.10
Identities = 72/383 (18%), Positives = 148/383 (38%), Gaps = 45/383 (11%)
Query: 383 KEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHLISTSSWRDGQ----KLVKKILG 438
+E E ++ + + + ++ +++A+ + R + +++ G+ K +I
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1856
Query: 439 PAPRMEPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERS------- 491
E + R + D + R + +A+ + RL L + ER
Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1916
Query: 492 -RSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVE 550
R + + E I L +S E A K L +E+ I + + T + +Q +E
Sbjct: 1917 LRQRRQVEEEILALKASF------EKAAAGKAELELELGRIRSNAE--DTLRSKEQAELE 1968
Query: 551 LQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRK 610
Q+ A R +R + A E+ +++R +EV + + +E R+ +
Sbjct: 1969 AARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRKAALEEVERLKAKVEEARRLR 2025
Query: 611 QNEEKKAQKE---ATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKL--- 664
+ E+++ ++ A E KRLQ ++ AF V E + LQ+ S L
Sbjct: 2026 ERAEQESARQLQLAQEAAQKRLQA--EEKAHAFA----VQQKEQELQQTLQQEQSVLDQL 2079
Query: 665 ----LLEKTLLEEPSHQHVTQETQAKPGYQPSGESDK-----ENKVQERPPSASSSSDMS 715
+ EE V E +A + E+++ E + Q R A ++++
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-AQAQAAAEKL 2138
Query: 716 LSEPPQPLARKDLMESTWMQPER 738
E Q AR+ E ++ ++
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQ 2161
Score = 33.1 bits (74), Expect = 4.4
Identities = 61/334 (18%), Positives = 124/334 (37%), Gaps = 44/334 (13%)
Query: 389 KSKEKKVVKPVRKVQKVAQLSST-----ECRTGSSHLISTSSWRDGQKLVKKILGPAPRM 443
K++ + V P +K + + S + RT S L + +S + +K I RM
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-----QYIKFISETLRRM 1344
Query: 444 EPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERSRSK--SRSENNI 501
E +E+ RER A+ + E +L H + +ER + R + +
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAAL---EKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 502 KKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVELQNQKSSAPVH 561
+ + D +Q++ + + E++ + + + A + + E + +
Sbjct: 1402 VRREEAAVDAQQQKRS------IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 562 A--------PRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNE 613
R + + + A + KR+ + E + V+ + +RKR+
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 614 EK----KAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKT 669
E KA+ EA +K + LQ L + +A A RRL++ + +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQA-----------EEAERRLRQAEVERARQVQ 1564
Query: 670 LLEEPSHQHVTQETQAKPGYQPSGESDKENKVQE 703
+ E + + E Q+K + E +QE
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598
Score = 32.7 bits (73), Expect = 5.8
Identities = 52/267 (19%), Positives = 107/267 (40%), Gaps = 35/267 (13%)
Query: 2619 SVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKENKDLI-SDATEKV 2677
S +D E L+ E + +Q + +L+ + +V + +E + L S +EK
Sbjct: 2441 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500
Query: 2678 S-------IAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQL 2730
S I E L+ F +E+ K QQ EE+ + + +E+ +L
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ------------MEQERQRL 2548
Query: 2731 EAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLG 2790
A ++ + + ++++ + + ++ + QL+Q ++ ++E + NQ L
Sbjct: 2549 VASMEEARRRQHEAEEGVRR------------KQEELQQLEQQRRQQEELLAEENQR-LR 2595
Query: 2791 DDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDEKEEISSPDMCPRPESPVFGASGQEEL 2850
+ + + Q + + + S + L + ++ + P PE F ++
Sbjct: 2596 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS-FDGLRRKVS 2654
Query: 2851 AKRLAELE-LSREFLSALGDDQDWFDE 2876
A+RL E LS E L L DE
Sbjct: 2655 AQRLQEAGILSAEELQRLAQGHTTVDE 2681
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 91.7 bits (226), Expect = 1e-17
Identities = 219/1114 (19%), Positives = 446/1114 (40%), Gaps = 162/1114 (14%)
Query: 1335 YLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALES 1394
Y+ I E++R++ + ER+ A+QQR E L +++A ALE
Sbjct: 1301 YIKFISETLRRMEEEERL------------------AEQQRAEERERLAEVEA---ALEK 1339
Query: 1395 QRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCK-----IAAQQSETA------- 1442
QRQL A+ HA++ Q + +E+ + +QE + + AQQ + +
Sbjct: 1340 QRQL-------AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1392
Query: 1443 -RLTTDA-----ARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTR- 1495
R +++A ARQ E AE +R I + + L + QR ++ LR R
Sbjct: 1393 LRQSSEAEIQAKARQ-AEAAERSRLRIEEEIRVVRLQLEAT-ERQRGGAEGELQALRARA 1450
Query: 1496 --TETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPS 1553
E ++ + + D +K A + S R E
Sbjct: 1451 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1510
Query: 1554 VPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDES 1613
+ +E E++L ++E + QVQ A + + RS + + + E + + + S
Sbjct: 1511 L-QAEEAERRLRQAEVERA--RQVQVALETAQRSAEA----ELQSKRASFAEKTAQLERS 1563
Query: 1614 MTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQ 1673
+ E+ + R + ++ E+ R + E E+ L + L + +
Sbjct: 1564 LQEEHVAVAQLREEAERRAQQQAEAERAR-----EEAERELERWQLKANEALRLRLQAEE 1618
Query: 1674 DSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGED 1733
+ K + + KEE R A + + E+A++++ ELA E +K+ R E
Sbjct: 1619 VAQQKSLAQAEAEKQKEEAEREARRRG--KAEEQAVRQR---ELAEQELEKQ--RQLAEG 1671
Query: 1734 DKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQE 1793
L +Q + LR + E+ E +R + AR +R+ Q+ +++ K++
Sbjct: 1672 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR-QELEAELAKVRA 1730
Query: 1794 KLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRM 1853
+++ SK + ++++++ S + E ++ ++ ++ ++ K+ R
Sbjct: 1731 EMEVLLASK--ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-- 1786
Query: 1854 DEKFLTKREQKLMQRRQHAEELLEWKRRLDAE------EAEIRQMEKQALAAWDKELIKP 1907
E+ ++R AE +L K E EAEI EK+A + L +
Sbjct: 1787 ------LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1840
Query: 1908 KT-PKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQP 1966
+ ++ LE+Q + K A EE L +SE + Q
Sbjct: 1841 EAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSEL--------------------ERQK 1878
Query: 1967 GSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
G ++ + + +++E K S K+ ++ E G R+ + L K
Sbjct: 1879 G-----LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1933
Query: 2027 HCYSWSDESLSMTQSETTSDQSD-IEGRIRALKDELRKRKSVVNQL-----KKEQKKRQK 2080
+ L+ + + + ++ + A ++ R+RK+ + ++ K E+ +R +
Sbjct: 1934 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 1993
Query: 2081 ERLK---------AQEASLIKQLESYDE----FIKKTEAELSQDLETSPTAKPQIKTLSS 2127
ER + AQEA+ K+L++ ++ +++ E EL Q L+ + Q++ +
Sbjct: 1994 ERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2052
Query: 2128 ASEK--PKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSL 2185
A+ + + + E A++ + + E+ER + S E A+ + + +E+ E
Sbjct: 2053 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112
Query: 2186 SAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREES----GDSLENVPALHL-LKELNATSR 2240
A A+R + Q + +K E++ + + L L L+E +
Sbjct: 2113 EA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2171
Query: 2241 ILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVL--LKLVLEQGDSSEIL 2298
+LD E ++ + + E + + E+ FS + + L LK +E + + IL
Sbjct: 2172 LLD-------EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2224
Query: 2299 SKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKE 2358
KD N Q+ L A + +EE + + Q+ + + +D+ +Q+ E
Sbjct: 2225 RDKD------NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAE 2277
Query: 2359 KDLSWSEHLFAPKEIP-YSEDFEVSSFKKEISAE 2391
K L E + A +E + E+ +KE++ E
Sbjct: 2278 KML--KEKMQAVQEATRLKAEAELLQQQKELAQE 2309
Score = 73.6 bits (179), Expect = 3e-12
Identities = 227/1261 (18%), Positives = 480/1261 (38%), Gaps = 182/1261 (14%)
Query: 1339 IEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
I+ RQ ER R + + ++ V Q+ ++QR + L L+A E E+Q+
Sbjct: 1401 IQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK-- 1457
Query: 1399 EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAEL 1458
+ AQ AE L++ VQ + ++ ++A ++A++ A + R + + EL
Sbjct: 1458 -----RQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1509
Query: 1459 TRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSK 1518
R +A RQ + +Q++ ET ++S L QSK + K
Sbjct: 1510 -RLQAEEAE-----------RRLRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAEK 1556
Query: 1519 HQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQ 1578
+ S + R + ++Q++ + + +E E++L +++++ +++
Sbjct: 1557 TAQLERSLQEEHVAVAQL---REEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1613
Query: 1579 TAADDSLRSDSVPSLPDEKDSTSI---------ATEYSLKFDESMTEDEIEEQSFRSLLP 1629
A++ + S+ EK A E +++ E + E E+E+Q R L
Sbjct: 1614 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE-LAEQELEKQ--RQLAE 1670
Query: 1630 SESHRRFNMEKRRGHHDDSDEEASPEKTTLSTA-KELNMPFSGGQDSFSKFTMEM--VRQ 1686
+ +R E+ E+ ++ L L + + E+ VR
Sbjct: 1671 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1730
Query: 1687 YMK---------EEEMRAAHQSSLLRLREKALKEKTKAE----LAWLEHQKKHLRDKGED 1733
M+ EEE R+ + S RL +A + + AE L L + K R E+
Sbjct: 1731 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1790
Query: 1734 DKMPPLRKKQRGLLLRLQQ--EKAEIKRLQEA---NKAARKERQLILKQQEEIEKIRQTT 1788
D + +R L +L E +K E K A ER L + E ++ R
Sbjct: 1791 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1850
Query: 1789 IKLQEK---------LKSAGESKLDSHS---DDDTKDNKATSPGPTDLETRSPSPISISS 1836
Q K L+ A +S+L+ +D + + L+ + ++
Sbjct: 1851 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK----ASFEKAA 1906
Query: 1837 SETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEE-------AEI 1889
+ + + +L ++RS ++ +K + +L RQ E +RR +AEE AE
Sbjct: 1907 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1966
Query: 1890 RQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELG 1949
++ A + E +K K + +R EQ+ + + L +E
Sbjct: 1967 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK------ 2020
Query: 1950 SPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSK 2009
+ + +Q L +E +L ++ + ++ +E+
Sbjct: 2021 --------AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA------EEARV 2066
Query: 2010 GSHRTGGQCHLPIKSHQHC-YSWSDESLSMTQSETTSD------QSDIEGRIRALKDELR 2062
+ R Q ++ + S +++ + Q++ ++ + + R +A + LR
Sbjct: 2067 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2126
Query: 2063 KRKSVVNQLKK-----EQKKRQKERLKAQEASLIKQLES-------YDEFIKKTEAEL-- 2108
++++ +++K EQ RQK +++ + +L QLE DE +++ +AE
Sbjct: 2127 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2186
Query: 2109 -----SQDLETSPTAKPQIKTLSSASEKPKI---------KPLTPLHRSETAKNWKSLTE 2154
SQ E + + Q++ LS + + K T E A+ K + E
Sbjct: 2187 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2246
Query: 2155 -------SERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSP 2207
+ + L +AE A +R+++E+ L + V E + +
Sbjct: 2247 EAARLSVAAQEAARLRQLAEEDLA----QQRALAEKMLKEKMQAVQE----ATRLKAEAE 2298
Query: 2208 VLRSSRKIREESGDSLE---NVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYT 2264
+L+ +++ +E L+ A L +E R L+ + E S ++E ++
Sbjct: 2299 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2358
Query: 2265 KLKKSKI---EDA--FSKEGK--SDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
++ +++ EDA F K+ + + L + L + ++ ++ + + +
Sbjct: 2359 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418
Query: 2318 AIENLHKSEEMLKERQS--DQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPY 2375
AI L + +E L++ +Q + + E + ++ LS + L +
Sbjct: 2419 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2478
Query: 2376 SEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEI 2435
E ++ +L++D+ + L + Q + + + R S + E
Sbjct: 2479 QEKAKLE--------QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2530
Query: 2436 SECLSEKSLSIHSNVHSDRLLE---------LKSPTELMKSKERSDVEHEQQVTESPSLA 2486
E + K + R E L+ +L++ + R+ + H ++VT S A
Sbjct: 2531 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2590
Query: 2487 S 2487
+
Sbjct: 2591 T 2591
Score = 73.6 bits (179), Expect = 3e-12
Identities = 180/910 (19%), Positives = 377/910 (41%), Gaps = 99/910 (10%)
Query: 1341 ESVRQLSDVERVRGISLAQQESV--SLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
E +Q + E R LA++ + +LA+ K Q+Q E D A + +AE+ E +
Sbjct: 1751 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1810
Query: 1399 EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAEL 1458
E + ++ +++R + + ++ + + + A+ D ++ ++ +
Sbjct: 1811 GEATRLKTEAEIALKEKEAENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK- 1868
Query: 1459 TRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTE---TDRKSPSVSLSQSKEGTL 1515
SD+ + L QR+ + + + L+ E + + L + +
Sbjct: 1869 ----ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1924
Query: 1516 DSKHQKYSASYDSYSESSGYKNHDRRSSSGSSR-QESPSVPSCKENEKKLNGEKIE---S 1571
D+ K A ++ + +RR R Q+S + ++K E++E +
Sbjct: 1925 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1984
Query: 1572 SIDEQVQTAADDSLRSDSVPSLPDEKDSTSI-ATEYSLKFDESMTEDEI-----EEQSFR 1625
++E + S L E + A E + F E E+ +EQS
Sbjct: 1985 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2044
Query: 1626 SLLPSESH-RRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMV 1684
L E+ R E+ ++ EA+ + + A+ L S + + ++ +
Sbjct: 2045 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ--SAEEQAQARAQAQAA 2102
Query: 1685 RQYM-KEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQK---KHLRDKGEDDKMPPLR 1740
+ + KE E AA ++ + + AL++K A+ +H+K + LR K +
Sbjct: 2103 AEKLRKEAEQEAARRA---QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ-------- 2151
Query: 1741 KKQRGLLLRLQQEKA---------EIKRLQ-EANKAARKERQLILKQQEEIEKIRQTTIK 1790
+Q LRLQ E+ E++RL+ EA +AAR+ Q+ +EE+ +R +
Sbjct: 2152 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV----EEELFSVRVQMEE 2207
Query: 1791 LQEKLKSAGESK---LDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLK 1847
L KLK+ E++ L D+T+ + +S+++ E + + Q +
Sbjct: 2208 L-SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2266
Query: 1848 K---MRSRMDEKFLTKREQKLMQ--RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDK 1902
+ + + EK L ++ Q + + R + ELL+ ++ L E+A Q +K+ +A
Sbjct: 2267 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2326
Query: 1903 ELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIG 1962
E + + ++ LE +R Q E+++E E + ++ + EE + +E IG
Sbjct: 2327 E--ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK--QAEEIG 2382
Query: 1963 QEQPGSPDHSILTEEMI-CSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLP 2021
++ + + T+E + Q LE S H + ++++ E K + + L
Sbjct: 2383 EKLHRT---ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-LQ 2438
Query: 2022 IKSHQHCYSWSDESLSMTQS---ETTSDQSDIEGRIRALKDELRKRKSV-------VNQL 2071
+KS + ++ L TQ+ S++ + R R ++ E K + + QL
Sbjct: 2439 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2498
Query: 2072 KKEQKKRQ------KERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTL 2125
++EQ+++Q ++RL A ++ +E +++ + EL Q LE + ++
Sbjct: 2499 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-QQLEQQRRQQEELLAE 2557
Query: 2126 SSASEKPKIKPLTPLHRSETAKNWKSLTESE--------RSRGSLESIAEHVDA--SLSG 2175
+ + +++ L HR+ A + + +T S+ R +L+ A + S G
Sbjct: 2558 ENQRLREQLQLLEEQHRAALAHS-EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDG 2616
Query: 2176 SERSVSERSL 2185
R VS + L
Sbjct: 2617 LRRKVSAQRL 2626
Score = 62.8 bits (151), Expect = 5e-09
Identities = 154/835 (18%), Positives = 304/835 (36%), Gaps = 132/835 (15%)
Query: 1136 EDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSSTSSKGK---------KGKKEKTEWLD 1186
E+ R+ A + + ++ + Q A+ K K + ++E L
Sbjct: 1946 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2005
Query: 1187 SFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTD-STLEDLSGHSVSVSS 1245
Q L EEKA + Q K+ ++ +QTL + S L+ L G + +
Sbjct: 2006 LAQEAAQKRLQAEEKAHAFAVQQKE---------QELQQTLQQEQSVLDQLRGEAEAARR 2056
Query: 1246 DKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASR 1305
+++ ++Q Q + A ER K S + A L A +
Sbjct: 2057 AAEEAEEARVQAEREAAQSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112
Query: 1306 TTTENMAPIPGSKRFSPAGLHHRMAAELS---YLNAIEESVRQLSDVER-VRGISLAQQE 1361
+ A L + AA+ + E+++RQ + VE+ + + L +E
Sbjct: 2113 EAARRA-------QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2165
Query: 1362 SVSLAQIIKAQQQR---HERDLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQ 1418
+ ++ + QR + A + + E+E + Q+EE A++ AE+ +++
Sbjct: 2166 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2225
Query: 1419 SQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELTRTHISDAVVASGAPLAILY 1478
+ LQE K+ E ARL+ AA++ + +L ++ A+
Sbjct: 2226 DKDNTQRFLQEEAEKMKQVAEEAARLSV-AAQEAARLRQLAEEDLAQ-------QRALAE 2277
Query: 1479 DHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNH 1538
++ + + R + E + L+Q + L + K + E+ G+
Sbjct: 2278 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL--QEDKEQMAQQLAEETQGF--- 2332
Query: 1539 DRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKD 1598
Q + ++ E E+++ + E + A
Sbjct: 2333 ----------QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR---------------- 2366
Query: 1599 STSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRF--NMEKRRGHHDDSDEEASPEK 1656
A E + +F + +EI E+ R+ L ++ +E +R D E
Sbjct: 2367 ----AEEDAQRFRKQ--AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2420
Query: 1657 TTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLR----LREKALKEK 1712
L KE K E +K EEM+ Q LL+ L++ L EK
Sbjct: 2421 AELEREKE-------------KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2467
Query: 1713 TK--AELAWLEHQKKHLRDKGEDD--KMPPLRKKQRGLLLRLQQEKAE-IKRLQEANKAA 1767
++E +K L +D+ K LR++Q+ +++QE+ + ++EA +
Sbjct: 2468 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2527
Query: 1768 RKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLD--------------SHSDDDTKD 1813
+ + + ++QEE++++ Q + QE+L + +L +HS++ T
Sbjct: 2528 HEAEEGVRRKQEELQQLEQQR-RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2586
Query: 1814 NKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKRE--QKLMQ---- 1867
A + + P + + E S + K R+ E + E Q+L Q
Sbjct: 2587 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTT 2646
Query: 1868 -----RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQ 1917
RR+ L+ + + + + AA ++L+ P T LE Q
Sbjct: 2647 VDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2701
Score = 58.2 bits (139), Expect = 1e-07
Identities = 132/715 (18%), Positives = 300/715 (41%), Gaps = 88/715 (12%)
Query: 1683 MVRQYMK--EEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLR 1740
+ QY+K E +R + L +++A + + AE+ +++ L + K R
Sbjct: 1297 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1356
Query: 1741 KKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTT-IKLQEKLKSAG 1799
+ + L R+Q+E + R +EA A+++++ I QEE++++RQ++ ++Q K + A
Sbjct: 1357 EAKE-LQQRMQEE---VVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQAE 1409
Query: 1800 ESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
++ ++ T+ + R + + + + + +K +++ + + L
Sbjct: 1410 AAERSRLRIEEEIRVVRLQLEATERQ-RGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1468
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRT 1919
++ Q QR++ AE L + + +AE A +Q QAL + + + ++ E +R
Sbjct: 1469 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1528
Query: 1920 EQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMI 1979
Q ++A E ++ S EL S + E+ + S+ E +
Sbjct: 1529 RQVQVALE-----------TAQRSAEAELQSKRASFA-------EKTAQLERSLQEEHVA 1570
Query: 1980 CSQ-ELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSM 2038
+Q E+ + + + +++E + + L +++ + +SL+
Sbjct: 1571 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA---QQKSLAQ 1627
Query: 2039 TQSETTSDQSDIEGRIRALKDE--LRKRKSVVNQLKKEQKKRQ---KERLKAQEASLIKQ 2093
++E ++++ E R R +E +R+R+ +L+K+++ + ++RL A++ + +
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1687
Query: 2094 LESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLT 2153
E+ + E + L A+ Q + ++ ++ +++ R+E
Sbjct: 1688 AET-------EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE--------- 1731
Query: 2154 ESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSR 2213
L S A + S S SE+ S++ L A A R E + + + R
Sbjct: 1732 ----MEVLLASKARAEEESRSTSEK--SKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1785
Query: 2214 KIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSK---KSEI----KEIEYTKL 2266
++ EE ++ R+L +GE+++ ++EI KE E +L
Sbjct: 1786 QLAEEDA-----------ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1834
Query: 2267 KKSKIEDAFSK--------EGKSDVLLKLV-LEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
++ ++AF + + K+D+ +L L + SE+ +K L D+ Q+ V
Sbjct: 1835 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-QRRQVEE 1893
Query: 2318 AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKE 2372
I L S E +++ ++ + +D K E + + L A +E
Sbjct: 1894 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1948
Score = 47.8 bits (112), Expect = 2e-04
Identities = 245/1386 (17%), Positives = 511/1386 (36%), Gaps = 225/1386 (16%)
Query: 1739 LRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLI-----LKQQEEIEKIRQTTIKLQE 1793
LR+ + L QQ E +RL E A K+RQL K Q E E ++ ++QE
Sbjct: 1309 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA-KELQQRMQE 1367
Query: 1794 KLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRM 1853
++ E+ +D+ + ++ L S + I + + + ++ R R+
Sbjct: 1368 EVVRREEAAVDAQ-----QQKRSIQEELQQLRQSSEAEIQAKARQAEAA----ERSRLRI 1418
Query: 1854 DEKFLTKREQKLMQRRQH--AEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPK 1911
+E+ R Q RQ AE L+ R AEEAE ++ + Q A + ++ ++ +
Sbjct: 1419 EEEIRVVRLQLEATERQRGGAEGELQ-ALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477
Query: 1912 K-----ELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEE-LGSPAVEYVPSESIGQEQ 1965
K EL + + E A E++ + L ++ E L VE + E
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE- 1536
Query: 1966 PGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSH 2025
T + EL+S + + S+ ++ + R ++
Sbjct: 1537 ---------TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE--------EAE 1579
Query: 2026 QHCYSWSDESLSMTQSETTSDQSDIEG----RIRALKDELRKRKSVVN---QLKKEQKKR 2078
+ ++ + ++E ++ ++ R+R +E+ ++KS+ + +KE+ +R
Sbjct: 1580 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1639
Query: 2079 QKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLT 2138
+ R E ++Q E ++ ++K + A+ ++ L + +E+ + +
Sbjct: 1640 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ--R 1697
Query: 2139 PLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSR 2198
L E A+ + + + R LE+ V A + E L++ A+ E S
Sbjct: 1698 QLLEEELARLQREAAAATQKRQELEAELAKVRAEM--------EVLLASKARAEEESRST 1749
Query: 2199 TEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEI 2258
+E +S +++ E+G E L E A R L E+ ++ ++
Sbjct: 1750 SE---------KSKQRLEAEAGRFRE-------LAEEAARLRAL------AEEAKRQRQL 1787
Query: 2259 KEIEYTKLKKSKIEDAFSKEGKSD-VLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
E EDA + +++ VL + + G+++ + ++ ++ L + + +
Sbjct: 1788 AE-----------EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE---- 1832
Query: 2318 AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSE 2377
+ L + E + R +Q H DI E+
Sbjct: 1833 RLRRLAEDEAFQRRRLEEQAAQHKA------DIEER------------------------ 1862
Query: 2378 DFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNE---E 2434
++ +K +EL + V L R+ + ++ +++S A + G E E
Sbjct: 1863 ---LAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKASFEKAAA-GKAELELE 1915
Query: 2435 ISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESPSLASVPTADEL 2494
+ S ++ S ++ LE +L +ER E E++V +S +
Sbjct: 1916 LGRIRSNAEDTLRSKEQAE--LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1973
Query: 2495 FDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKH 2554
+R+ + LR + E A+ E + + +EK
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR------------LQAEEKA 2021
Query: 2555 GIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYE 2614
FA QK E Q QEQ+ + + E + + E
Sbjct: 2022 HAFAVQQK---------------------EQELQQTLQQEQSVLDQLRG-EAEAARRAAE 2059
Query: 2615 KSLPSVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKE-NKDLISDA 2673
++ + E +SR E + ++ A Q+ +Q ++++ K+ +A
Sbjct: 2060 EAEEARVQAEREAAQSRRQVEEAERLKQ-----SAEEQAQARAQAQAAAEKLRKEAEQEA 2114
Query: 2674 TEKVSIAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLL---------DLLT 2724
+ E+EK ++F E+ A+ ++L T L +LL
Sbjct: 2115 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2174
Query: 2725 REKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLS 2784
E +L+A+ + + + +++L + + + L K+ + I + +D +
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2234
Query: 2785 NQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDE--------KEEISSPDMCPR 2836
+E + K+V + +V Q + +L + KE++ + R
Sbjct: 2235 QEE--AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292
Query: 2837 PESPVFGASGQEELAKRLA-ELELSREFLSALGDDQDWFDEDFGLSSSHKIQKNKAEETI 2895
++ Q+ELA+ A L+ +E ++ Q +E G + + ++ + E
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMA-----QQLAEETQGFQRTLEAERQRQLE-- 2345
Query: 2896 VPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKELGHDLHSISIPTKLLG 2955
+ AE +R+ + E A E+ + A +E+G LH + T+
Sbjct: 2346 --MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLHRTELATQEKV 2396
Query: 2956 CASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMKPCRINSSYFRRVKNP 3015
+ L+I+ R + +E E+ E L Q K ++ S + V+
Sbjct: 2397 TLVQTLEIQ----RQQSDHDAERLREAIAELEREKEKLQQEA--KLLQLKSEEMQTVQQE 2450
Query: 3016 NNLDEIKSFIASEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVDHILVQELHEEEAQWV 3075
L E ++ S + + SL + + Q+ K + +D V Q+L EE+ +
Sbjct: 2451 QLLQETQALQQSFLSEKDSLLQ--RERFIEQEKAKLEQLFQDEV--AKAQQLREEQQRQQ 2506
Query: 3076 NYDEDE 3081
E E
Sbjct: 2507 QQMEQE 2512
Score = 47.4 bits (111), Expect = 2e-04
Identities = 109/504 (21%), Positives = 195/504 (38%), Gaps = 71/504 (14%)
Query: 1749 RLQQEKAEIKRLQEANKAA---RKERQLILKQQEEIEKI------RQTTIKLQEKLKSAG 1799
RL E ++ L E + AA R E +L L + E++ + + TI L +
Sbjct: 1010 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1069
Query: 1800 ESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
E L +H ++ K+ +A +LE T + ++KL+ F
Sbjct: 1070 EEVLRAH-EEQLKEAQAVPATLPELEA------------TKASLKKLRAQAEAQQPTFDA 1116
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRT 1919
R++ L ++ E L + D E R+ Q L W L + ++ELE
Sbjct: 1117 LRDE-LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQL-- 1173
Query: 1920 EQKEIASEEESPVPLYSHLNSESSIPEELGSP--AVEYVPSESIGQEQPGSPD---HSIL 1974
+++ ES PL + L E++ + A E + QEQ + H
Sbjct: 1174 -GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1232
Query: 1975 TEE--------MICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
EE + ++ E K L + K + GS Q ++ +++H
Sbjct: 1233 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTH- 1290
Query: 2027 HCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQ 2086
SE T+ S I+ + + LR R +L ++Q+ ++ERL
Sbjct: 1291 -------------YSELTTLTSQY---IKFISETLR-RMEEEERLAEQQRAEERERLAEV 1333
Query: 2087 EASLIKQLESYDEFIK-KTEA-----ELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPL 2140
EA+L KQ + + + K +A EL Q ++ + + + ++ + L L
Sbjct: 1334 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1393
Query: 2141 HRSETAK---NWKSLTESERSRGSLESIAEHVDASLSGSE--RSVSERSLSAYAKRVNEW 2195
+S A+ + +ERSR +E V L +E R +E L A R E
Sbjct: 1394 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1453
Query: 2196 DSRTEDFQTPSPVLRSSRKIREES 2219
+++ Q + LR R++++ES
Sbjct: 1454 EAQKRQAQEEAERLR--RQVQDES 1475
Score = 39.7 bits (91), Expect = 0.047
Identities = 64/315 (20%), Positives = 125/315 (39%), Gaps = 31/315 (9%)
Query: 358 EAEFQNMSRELYRDLALHFADDISIKEKPAEKSKEKKV-------VKPVRKVQKVAQLSS 410
EAE +EL ++ A +D KE+ A++ E+ + R+++ A+
Sbjct: 2296 EAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352
Query: 411 TECRTGSSHLISTSSWRDGQKLVKKILGPAPRMEPKEQRTASSDRGGRERTAKSGGHIGR 470
+ R + D Q+ K+ A + K RT + + + T I R
Sbjct: 2353 LKLRVAEMSRAQARAEEDAQRFRKQ----AEEIGEKLHRTELATQ--EKVTLVQTLEIQR 2406
Query: 471 AESDPRLDVLHRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRG 530
+SD + L R ER + K + E + +L S Q+E L
Sbjct: 2407 QQSDHDAERL-REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2465
Query: 531 ILDDLQLDSTAHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVIS---- 586
D L +Q+ +L+ A + +R+ ++ V S
Sbjct: 2466 EKDSLL--QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2523
Query: 587 KRRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQE----LYRKQKEAFTK 642
+RR ++ +E VR+++E ++ ++++ Q+E ++N+RL+E L + + A
Sbjct: 2524 RRRQHEAEEG----VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2579
Query: 643 VKNVPPSEPSATRRL 657
+ V S+ +AT+ L
Sbjct: 2580 SEEVTASQVAATKTL 2594
Score = 38.5 bits (88), Expect = 0.10
Identities = 72/383 (18%), Positives = 148/383 (38%), Gaps = 45/383 (11%)
Query: 383 KEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHLISTSSWRDGQ----KLVKKILG 438
+E E ++ + + + ++ +++A+ + R + +++ G+ K +I
Sbjct: 1765 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1824
Query: 439 PAPRMEPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERS------- 491
E + R + D + R + +A+ + RL L + ER
Sbjct: 1825 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1884
Query: 492 -RSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVE 550
R + + E I L +S E A K L +E+ I + + T + +Q +E
Sbjct: 1885 LRQRRQVEEEILALKASF------EKAAAGKAELELELGRIRSNAE--DTLRSKEQAELE 1936
Query: 551 LQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRK 610
Q+ A R +R + A E+ +++R +EV + + +E R+ +
Sbjct: 1937 AARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRKAALEEVERLKAKVEEARRLR 1993
Query: 611 QNEEKKAQKE---ATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKL--- 664
+ E+++ ++ A E KRLQ ++ AF V E + LQ+ S L
Sbjct: 1994 ERAEQESARQLQLAQEAAQKRLQA--EEKAHAFA----VQQKEQELQQTLQQEQSVLDQL 2047
Query: 665 ----LLEKTLLEEPSHQHVTQETQAKPGYQPSGESDK-----ENKVQERPPSASSSSDMS 715
+ EE V E +A + E+++ E + Q R A ++++
Sbjct: 2048 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-AQAQAAAEKL 2106
Query: 716 LSEPPQPLARKDLMESTWMQPER 738
E Q AR+ E ++ ++
Sbjct: 2107 RKEAEQEAARRAQAEQAALRQKQ 2129
Score = 33.1 bits (74), Expect = 4.4
Identities = 61/334 (18%), Positives = 124/334 (37%), Gaps = 44/334 (13%)
Query: 389 KSKEKKVVKPVRKVQKVAQLSST-----ECRTGSSHLISTSSWRDGQKLVKKILGPAPRM 443
K++ + V P +K + + S + RT S L + +S + +K I RM
Sbjct: 1258 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-----QYIKFISETLRRM 1312
Query: 444 EPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERSRSK--SRSENNI 501
E +E+ RER A+ + E +L H + +ER + R + +
Sbjct: 1313 EEEERLAEQQRAEERERLAEVEAAL---EKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1369
Query: 502 KKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVELQNQKSSAPVH 561
+ + D +Q++ + + E++ + + + A + + E + +
Sbjct: 1370 VRREEAAVDAQQQKRS------IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1423
Query: 562 A--------PRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNE 613
R + + + A + KR+ + E + V+ + +RKR+
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1483
Query: 614 EK----KAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKT 669
E KA+ EA +K + LQ L + +A A RRL++ + +
Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQA-----------EEAERRLRQAEVERARQVQ 1532
Query: 670 LLEEPSHQHVTQETQAKPGYQPSGESDKENKVQE 703
+ E + + E Q+K + E +QE
Sbjct: 1533 VALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1566
Score = 32.7 bits (73), Expect = 5.8
Identities = 52/267 (19%), Positives = 107/267 (40%), Gaps = 35/267 (13%)
Query: 2619 SVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKENKDLI-SDATEKV 2677
S +D E L+ E + +Q + +L+ + +V + +E + L S +EK
Sbjct: 2409 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2468
Query: 2678 S-------IAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQL 2730
S I E L+ F +E+ K QQ EE+ + + +E+ +L
Sbjct: 2469 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ------------MEQERQRL 2516
Query: 2731 EAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLG 2790
A ++ + + ++++ + + ++ + QL+Q ++ ++E + NQ L
Sbjct: 2517 VASMEEARRRQHEAEEGVRR------------KQEELQQLEQQRRQQEELLAEENQR-LR 2563
Query: 2791 DDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDEKEEISSPDMCPRPESPVFGASGQEEL 2850
+ + + Q + + + S + L + ++ + P PE F ++
Sbjct: 2564 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS-FDGLRRKVS 2622
Query: 2851 AKRLAELE-LSREFLSALGDDQDWFDE 2876
A+RL E LS E L L DE
Sbjct: 2623 AQRLQEAGILSAEELQRLAQGHTTVDE 2649
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 91.7 bits (226), Expect = 1e-17
Identities = 219/1114 (19%), Positives = 446/1114 (40%), Gaps = 162/1114 (14%)
Query: 1335 YLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALES 1394
Y+ I E++R++ + ER+ A+QQR E L +++A ALE
Sbjct: 1470 YIKFISETLRRMEEEERL------------------AEQQRAEERERLAEVEA---ALEK 1508
Query: 1395 QRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCK-----IAAQQSETA------- 1442
QRQL A+ HA++ Q + +E+ + +QE + + AQQ + +
Sbjct: 1509 QRQL-------AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1561
Query: 1443 -RLTTDA-----ARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTR- 1495
R +++A ARQ E AE +R I + + L + QR ++ LR R
Sbjct: 1562 LRQSSEAEIQAKARQ-AEAAERSRLRIEEEIRVVRLQLEAT-ERQRGGAEGELQALRARA 1619
Query: 1496 --TETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPS 1553
E ++ + + D +K A + S R E
Sbjct: 1620 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1679
Query: 1554 VPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDES 1613
+ +E E++L ++E + QVQ A + + RS + + + E + + + S
Sbjct: 1680 L-QAEEAERRLRQAEVERA--RQVQVALETAQRSAEA----ELQSKRASFAEKTAQLERS 1732
Query: 1614 MTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQ 1673
+ E+ + R + ++ E+ R + E E+ L + L + +
Sbjct: 1733 LQEEHVAVAQLREEAERRAQQQAEAERAR-----EEAERELERWQLKANEALRLRLQAEE 1787
Query: 1674 DSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGED 1733
+ K + + KEE R A + + E+A++++ ELA E +K+ R E
Sbjct: 1788 VAQQKSLAQAEAEKQKEEAEREARRRG--KAEEQAVRQR---ELAEQELEKQ--RQLAEG 1840
Query: 1734 DKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQE 1793
L +Q + LR + E+ E +R + AR +R+ Q+ +++ K++
Sbjct: 1841 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR-QELEAELAKVRA 1899
Query: 1794 KLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRM 1853
+++ SK + ++++++ S + E ++ ++ ++ ++ K+ R
Sbjct: 1900 EMEVLLASK--ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-- 1955
Query: 1854 DEKFLTKREQKLMQRRQHAEELLEWKRRLDAE------EAEIRQMEKQALAAWDKELIKP 1907
E+ ++R AE +L K E EAEI EK+A + L +
Sbjct: 1956 ------LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 2009
Query: 1908 KT-PKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQP 1966
+ ++ LE+Q + K A EE L +SE + Q
Sbjct: 2010 EAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSEL--------------------ERQK 2047
Query: 1967 GSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
G ++ + + +++E K S K+ ++ E G R+ + L K
Sbjct: 2048 G-----LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 2102
Query: 2027 HCYSWSDESLSMTQSETTSDQSD-IEGRIRALKDELRKRKSVVNQL-----KKEQKKRQK 2080
+ L+ + + + ++ + A ++ R+RK+ + ++ K E+ +R +
Sbjct: 2103 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2162
Query: 2081 ERLK---------AQEASLIKQLESYDE----FIKKTEAELSQDLETSPTAKPQIKTLSS 2127
ER + AQEA+ K+L++ ++ +++ E EL Q L+ + Q++ +
Sbjct: 2163 ERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2221
Query: 2128 ASEK--PKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSL 2185
A+ + + + E A++ + + E+ER + S E A+ + + +E+ E
Sbjct: 2222 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281
Query: 2186 SAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREES----GDSLENVPALHL-LKELNATSR 2240
A A+R + Q + +K E++ + + L L L+E +
Sbjct: 2282 EA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2340
Query: 2241 ILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVL--LKLVLEQGDSSEIL 2298
+LD E ++ + + E + + E+ FS + + L LK +E + + IL
Sbjct: 2341 LLD-------EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2393
Query: 2299 SKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKE 2358
KD N Q+ L A + +EE + + Q+ + + +D+ +Q+ E
Sbjct: 2394 RDKD------NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAE 2446
Query: 2359 KDLSWSEHLFAPKEIP-YSEDFEVSSFKKEISAE 2391
K L E + A +E + E+ +KE++ E
Sbjct: 2447 KML--KEKMQAVQEATRLKAEAELLQQQKELAQE 2478
Score = 73.6 bits (179), Expect = 3e-12
Identities = 227/1261 (18%), Positives = 480/1261 (38%), Gaps = 182/1261 (14%)
Query: 1339 IEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
I+ RQ ER R + + ++ V Q+ ++QR + L L+A E E+Q+
Sbjct: 1570 IQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK-- 1626
Query: 1399 EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAEL 1458
+ AQ AE L++ VQ + ++ ++A ++A++ A + R + + EL
Sbjct: 1627 -----RQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1678
Query: 1459 TRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSK 1518
R +A RQ + +Q++ ET ++S L QSK + K
Sbjct: 1679 -RLQAEEAE-----------RRLRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAEK 1725
Query: 1519 HQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQ 1578
+ S + R + ++Q++ + + +E E++L +++++ +++
Sbjct: 1726 TAQLERSLQEEHVAVAQL---REEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1782
Query: 1579 TAADDSLRSDSVPSLPDEKDSTSI---------ATEYSLKFDESMTEDEIEEQSFRSLLP 1629
A++ + S+ EK A E +++ E + E E+E+Q R L
Sbjct: 1783 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE-LAEQELEKQ--RQLAE 1839
Query: 1630 SESHRRFNMEKRRGHHDDSDEEASPEKTTLSTA-KELNMPFSGGQDSFSKFTMEM--VRQ 1686
+ +R E+ E+ ++ L L + + E+ VR
Sbjct: 1840 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1899
Query: 1687 YMK---------EEEMRAAHQSSLLRLREKALKEKTKAE----LAWLEHQKKHLRDKGED 1733
M+ EEE R+ + S RL +A + + AE L L + K R E+
Sbjct: 1900 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1959
Query: 1734 DKMPPLRKKQRGLLLRLQQ--EKAEIKRLQEA---NKAARKERQLILKQQEEIEKIRQTT 1788
D + +R L +L E +K E K A ER L + E ++ R
Sbjct: 1960 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 2019
Query: 1789 IKLQEK---------LKSAGESKLDSHS---DDDTKDNKATSPGPTDLETRSPSPISISS 1836
Q K L+ A +S+L+ +D + + L+ + ++
Sbjct: 2020 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK----ASFEKAA 2075
Query: 1837 SETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEE-------AEI 1889
+ + + +L ++RS ++ +K + +L RQ E +RR +AEE AE
Sbjct: 2076 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2135
Query: 1890 RQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELG 1949
++ A + E +K K + +R EQ+ + + L +E
Sbjct: 2136 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK------ 2189
Query: 1950 SPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSK 2009
+ + +Q L +E +L ++ + ++ +E+
Sbjct: 2190 --------AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA------EEARV 2235
Query: 2010 GSHRTGGQCHLPIKSHQHC-YSWSDESLSMTQSETTSD------QSDIEGRIRALKDELR 2062
+ R Q ++ + S +++ + Q++ ++ + + R +A + LR
Sbjct: 2236 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2295
Query: 2063 KRKSVVNQLKK-----EQKKRQKERLKAQEASLIKQLES-------YDEFIKKTEAEL-- 2108
++++ +++K EQ RQK +++ + +L QLE DE +++ +AE
Sbjct: 2296 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2355
Query: 2109 -----SQDLETSPTAKPQIKTLSSASEKPKI---------KPLTPLHRSETAKNWKSLTE 2154
SQ E + + Q++ LS + + K T E A+ K + E
Sbjct: 2356 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2415
Query: 2155 -------SERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSP 2207
+ + L +AE A +R+++E+ L + V E + +
Sbjct: 2416 EAARLSVAAQEAARLRQLAEEDLA----QQRALAEKMLKEKMQAVQE----ATRLKAEAE 2467
Query: 2208 VLRSSRKIREESGDSLE---NVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYT 2264
+L+ +++ +E L+ A L +E R L+ + E S ++E ++
Sbjct: 2468 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2527
Query: 2265 KLKKSKI---EDA--FSKEGK--SDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
++ +++ EDA F K+ + + L + L + ++ ++ + + +
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587
Query: 2318 AIENLHKSEEMLKERQS--DQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPY 2375
AI L + +E L++ +Q + + E + ++ LS + L +
Sbjct: 2588 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2647
Query: 2376 SEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEI 2435
E ++ +L++D+ + L + Q + + + R S + E
Sbjct: 2648 QEKAKLE--------QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2699
Query: 2436 SECLSEKSLSIHSNVHSDRLLE---------LKSPTELMKSKERSDVEHEQQVTESPSLA 2486
E + K + R E L+ +L++ + R+ + H ++VT S A
Sbjct: 2700 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2759
Query: 2487 S 2487
+
Sbjct: 2760 T 2760
Score = 73.6 bits (179), Expect = 3e-12
Identities = 180/910 (19%), Positives = 377/910 (41%), Gaps = 99/910 (10%)
Query: 1341 ESVRQLSDVERVRGISLAQQESV--SLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
E +Q + E R LA++ + +LA+ K Q+Q E D A + +AE+ E +
Sbjct: 1920 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1979
Query: 1399 EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAEL 1458
E + ++ +++R + + ++ + + + A+ D ++ ++ +
Sbjct: 1980 GEATRLKTEAEIALKEKEAENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK- 2037
Query: 1459 TRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTE---TDRKSPSVSLSQSKEGTL 1515
SD+ + L QR+ + + + L+ E + + L + +
Sbjct: 2038 ----ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 2093
Query: 1516 DSKHQKYSASYDSYSESSGYKNHDRRSSSGSSR-QESPSVPSCKENEKKLNGEKIE---S 1571
D+ K A ++ + +RR R Q+S + ++K E++E +
Sbjct: 2094 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2153
Query: 1572 SIDEQVQTAADDSLRSDSVPSLPDEKDSTSI-ATEYSLKFDESMTEDEI-----EEQSFR 1625
++E + S L E + A E + F E E+ +EQS
Sbjct: 2154 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2213
Query: 1626 SLLPSESH-RRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMV 1684
L E+ R E+ ++ EA+ + + A+ L S + + ++ +
Sbjct: 2214 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ--SAEEQAQARAQAQAA 2271
Query: 1685 RQYM-KEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQK---KHLRDKGEDDKMPPLR 1740
+ + KE E AA ++ + + AL++K A+ +H+K + LR K +
Sbjct: 2272 AEKLRKEAEQEAARRA---QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ-------- 2320
Query: 1741 KKQRGLLLRLQQEKA---------EIKRLQ-EANKAARKERQLILKQQEEIEKIRQTTIK 1790
+Q LRLQ E+ E++RL+ EA +AAR+ Q+ +EE+ +R +
Sbjct: 2321 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV----EEELFSVRVQMEE 2376
Query: 1791 LQEKLKSAGESK---LDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLK 1847
L KLK+ E++ L D+T+ + +S+++ E + + Q +
Sbjct: 2377 L-SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2435
Query: 1848 K---MRSRMDEKFLTKREQKLMQ--RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDK 1902
+ + + EK L ++ Q + + R + ELL+ ++ L E+A Q +K+ +A
Sbjct: 2436 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2495
Query: 1903 ELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIG 1962
E + + ++ LE +R Q E+++E E + ++ + EE + +E IG
Sbjct: 2496 E--ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK--QAEEIG 2551
Query: 1963 QEQPGSPDHSILTEEMI-CSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLP 2021
++ + + T+E + Q LE S H + ++++ E K + + L
Sbjct: 2552 EKLHRT---ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-LQ 2607
Query: 2022 IKSHQHCYSWSDESLSMTQS---ETTSDQSDIEGRIRALKDELRKRKSV-------VNQL 2071
+KS + ++ L TQ+ S++ + R R ++ E K + + QL
Sbjct: 2608 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2667
Query: 2072 KKEQKKRQ------KERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTL 2125
++EQ+++Q ++RL A ++ +E +++ + EL Q LE + ++
Sbjct: 2668 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-QQLEQQRRQQEELLAE 2726
Query: 2126 SSASEKPKIKPLTPLHRSETAKNWKSLTESE--------RSRGSLESIAEHVDA--SLSG 2175
+ + +++ L HR+ A + + +T S+ R +L+ A + S G
Sbjct: 2727 ENQRLREQLQLLEEQHRAALAHS-EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDG 2785
Query: 2176 SERSVSERSL 2185
R VS + L
Sbjct: 2786 LRRKVSAQRL 2795
Score = 62.8 bits (151), Expect = 5e-09
Identities = 154/835 (18%), Positives = 304/835 (36%), Gaps = 132/835 (15%)
Query: 1136 EDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSSTSSKGK---------KGKKEKTEWLD 1186
E+ R+ A + + ++ + Q A+ K K + ++E L
Sbjct: 2115 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2174
Query: 1187 SFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTD-STLEDLSGHSVSVSS 1245
Q L EEKA + Q K+ ++ +QTL + S L+ L G + +
Sbjct: 2175 LAQEAAQKRLQAEEKAHAFAVQQKE---------QELQQTLQQEQSVLDQLRGEAEAARR 2225
Query: 1246 DKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASR 1305
+++ ++Q Q + A ER K S + A L A +
Sbjct: 2226 AAEEAEEARVQAEREAAQSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281
Query: 1306 TTTENMAPIPGSKRFSPAGLHHRMAAELS---YLNAIEESVRQLSDVER-VRGISLAQQE 1361
+ A L + AA+ + E+++RQ + VE+ + + L +E
Sbjct: 2282 EAARRA-------QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334
Query: 1362 SVSLAQIIKAQQQR---HERDLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQ 1418
+ ++ + QR + A + + E+E + Q+EE A++ AE+ +++
Sbjct: 2335 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2394
Query: 1419 SQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELTRTHISDAVVASGAPLAILY 1478
+ LQE K+ E ARL+ AA++ + +L ++ A+
Sbjct: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSV-AAQEAARLRQLAEEDLAQ-------QRALAE 2446
Query: 1479 DHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNH 1538
++ + + R + E + L+Q + L + K + E+ G+
Sbjct: 2447 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL--QEDKEQMAQQLAEETQGF--- 2501
Query: 1539 DRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKD 1598
Q + ++ E E+++ + E + A
Sbjct: 2502 ----------QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR---------------- 2535
Query: 1599 STSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRF--NMEKRRGHHDDSDEEASPEK 1656
A E + +F + +EI E+ R+ L ++ +E +R D E
Sbjct: 2536 ----AEEDAQRFRKQ--AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2589
Query: 1657 TTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLR----LREKALKEK 1712
L KE K E +K EEM+ Q LL+ L++ L EK
Sbjct: 2590 AELEREKE-------------KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2636
Query: 1713 TK--AELAWLEHQKKHLRDKGEDD--KMPPLRKKQRGLLLRLQQEKAE-IKRLQEANKAA 1767
++E +K L +D+ K LR++Q+ +++QE+ + ++EA +
Sbjct: 2637 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2696
Query: 1768 RKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLD--------------SHSDDDTKD 1813
+ + + ++QEE++++ Q + QE+L + +L +HS++ T
Sbjct: 2697 HEAEEGVRRKQEELQQLEQQR-RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2755
Query: 1814 NKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKRE--QKLMQ---- 1867
A + + P + + E S + K R+ E + E Q+L Q
Sbjct: 2756 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTT 2815
Query: 1868 -----RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQ 1917
RR+ L+ + + + + AA ++L+ P T LE Q
Sbjct: 2816 VDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2870
Score = 58.2 bits (139), Expect = 1e-07
Identities = 132/715 (18%), Positives = 300/715 (41%), Gaps = 88/715 (12%)
Query: 1683 MVRQYMK--EEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLR 1740
+ QY+K E +R + L +++A + + AE+ +++ L + K R
Sbjct: 1466 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1525
Query: 1741 KKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTT-IKLQEKLKSAG 1799
+ + L R+Q+E + R +EA A+++++ I QEE++++RQ++ ++Q K + A
Sbjct: 1526 EAKE-LQQRMQEE---VVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQAE 1578
Query: 1800 ESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
++ ++ T+ + R + + + + + +K +++ + + L
Sbjct: 1579 AAERSRLRIEEEIRVVRLQLEATERQ-RGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1637
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRT 1919
++ Q QR++ AE L + + +AE A +Q QAL + + + ++ E +R
Sbjct: 1638 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1697
Query: 1920 EQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMI 1979
Q ++A E ++ S EL S + E+ + S+ E +
Sbjct: 1698 RQVQVALE-----------TAQRSAEAELQSKRASFA-------EKTAQLERSLQEEHVA 1739
Query: 1980 CSQ-ELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSM 2038
+Q E+ + + + +++E + + L +++ + +SL+
Sbjct: 1740 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA---QQKSLAQ 1796
Query: 2039 TQSETTSDQSDIEGRIRALKDE--LRKRKSVVNQLKKEQKKRQ---KERLKAQEASLIKQ 2093
++E ++++ E R R +E +R+R+ +L+K+++ + ++RL A++ + +
Sbjct: 1797 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1856
Query: 2094 LESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLT 2153
E+ + E + L A+ Q + ++ ++ +++ R+E
Sbjct: 1857 AET-------EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE--------- 1900
Query: 2154 ESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSR 2213
L S A + S S SE+ S++ L A A R E + + + R
Sbjct: 1901 ----MEVLLASKARAEEESRSTSEK--SKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1954
Query: 2214 KIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSK---KSEI----KEIEYTKL 2266
++ EE ++ R+L +GE+++ ++EI KE E +L
Sbjct: 1955 QLAEEDA-----------ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 2003
Query: 2267 KKSKIEDAFSK--------EGKSDVLLKLV-LEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
++ ++AF + + K+D+ +L L + SE+ +K L D+ Q+ V
Sbjct: 2004 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-QRRQVEE 2062
Query: 2318 AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKE 2372
I L S E +++ ++ + +D K E + + L A +E
Sbjct: 2063 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2117
Score = 47.8 bits (112), Expect = 2e-04
Identities = 245/1386 (17%), Positives = 511/1386 (36%), Gaps = 225/1386 (16%)
Query: 1739 LRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLI-----LKQQEEIEKIRQTTIKLQE 1793
LR+ + L QQ E +RL E A K+RQL K Q E E ++ ++QE
Sbjct: 1478 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA-KELQQRMQE 1536
Query: 1794 KLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRM 1853
++ E+ +D+ + ++ L S + I + + + ++ R R+
Sbjct: 1537 EVVRREEAAVDAQ-----QQKRSIQEELQQLRQSSEAEIQAKARQAEAA----ERSRLRI 1587
Query: 1854 DEKFLTKREQKLMQRRQH--AEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPK 1911
+E+ R Q RQ AE L+ R AEEAE ++ + Q A + ++ ++ +
Sbjct: 1588 EEEIRVVRLQLEATERQRGGAEGELQ-ALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646
Query: 1912 K-----ELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEE-LGSPAVEYVPSESIGQEQ 1965
K EL + + E A E++ + L ++ E L VE + E
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE- 1705
Query: 1966 PGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSH 2025
T + EL+S + + S+ ++ + R ++
Sbjct: 1706 ---------TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE--------EAE 1748
Query: 2026 QHCYSWSDESLSMTQSETTSDQSDIEG----RIRALKDELRKRKSVVN---QLKKEQKKR 2078
+ ++ + ++E ++ ++ R+R +E+ ++KS+ + +KE+ +R
Sbjct: 1749 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1808
Query: 2079 QKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLT 2138
+ R E ++Q E ++ ++K + A+ ++ L + +E+ + +
Sbjct: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ--R 1866
Query: 2139 PLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSR 2198
L E A+ + + + R LE+ V A + E L++ A+ E S
Sbjct: 1867 QLLEEELARLQREAAAATQKRQELEAELAKVRAEM--------EVLLASKARAEEESRST 1918
Query: 2199 TEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEI 2258
+E +S +++ E+G E L E A R L E+ ++ ++
Sbjct: 1919 SE---------KSKQRLEAEAGRFRE-------LAEEAARLRAL------AEEAKRQRQL 1956
Query: 2259 KEIEYTKLKKSKIEDAFSKEGKSD-VLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
E EDA + +++ VL + + G+++ + ++ ++ L + + +
Sbjct: 1957 AE-----------EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE---- 2001
Query: 2318 AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSE 2377
+ L + E + R +Q H DI E+
Sbjct: 2002 RLRRLAEDEAFQRRRLEEQAAQHKA------DIEER------------------------ 2031
Query: 2378 DFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNE---E 2434
++ +K +EL + V L R+ + ++ +++S A + G E E
Sbjct: 2032 ---LAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKASFEKAAA-GKAELELE 2084
Query: 2435 ISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESPSLASVPTADEL 2494
+ S ++ S ++ LE +L +ER E E++V +S +
Sbjct: 2085 LGRIRSNAEDTLRSKEQAE--LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2142
Query: 2495 FDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKH 2554
+R+ + LR + E A+ E + + +EK
Sbjct: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR------------LQAEEKA 2190
Query: 2555 GIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYE 2614
FA QK E Q QEQ+ + + E + + E
Sbjct: 2191 HAFAVQQK---------------------EQELQQTLQQEQSVLDQLRG-EAEAARRAAE 2228
Query: 2615 KSLPSVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKE-NKDLISDA 2673
++ + E +SR E + ++ A Q+ +Q ++++ K+ +A
Sbjct: 2229 EAEEARVQAEREAAQSRRQVEEAERLKQ-----SAEEQAQARAQAQAAAEKLRKEAEQEA 2283
Query: 2674 TEKVSIAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLL---------DLLT 2724
+ E+EK ++F E+ A+ ++L T L +LL
Sbjct: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343
Query: 2725 REKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLS 2784
E +L+A+ + + + +++L + + + L K+ + I + +D +
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2403
Query: 2785 NQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDE--------KEEISSPDMCPR 2836
+E + K+V + +V Q + +L + KE++ + R
Sbjct: 2404 QEE--AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461
Query: 2837 PESPVFGASGQEELAKRLA-ELELSREFLSALGDDQDWFDEDFGLSSSHKIQKNKAEETI 2895
++ Q+ELA+ A L+ +E ++ Q +E G + + ++ + E
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMA-----QQLAEETQGFQRTLEAERQRQLE-- 2514
Query: 2896 VPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKELGHDLHSISIPTKLLG 2955
+ AE +R+ + E A E+ + A +E+G LH + T+
Sbjct: 2515 --MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLHRTELATQEKV 2565
Query: 2956 CASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMKPCRINSSYFRRVKNP 3015
+ L+I+ R + +E E+ E L Q K ++ S + V+
Sbjct: 2566 TLVQTLEIQ----RQQSDHDAERLREAIAELEREKEKLQQEA--KLLQLKSEEMQTVQQE 2619
Query: 3016 NNLDEIKSFIASEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVDHILVQELHEEEAQWV 3075
L E ++ S + + SL + + Q+ K + +D V Q+L EE+ +
Sbjct: 2620 QLLQETQALQQSFLSEKDSLLQ--RERFIEQEKAKLEQLFQDEV--AKAQQLREEQQRQQ 2675
Query: 3076 NYDEDE 3081
E E
Sbjct: 2676 QQMEQE 2681
Score = 47.4 bits (111), Expect = 2e-04
Identities = 109/504 (21%), Positives = 195/504 (38%), Gaps = 71/504 (14%)
Query: 1749 RLQQEKAEIKRLQEANKAA---RKERQLILKQQEEIEKI------RQTTIKLQEKLKSAG 1799
RL E ++ L E + AA R E +L L + E++ + + TI L +
Sbjct: 1179 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1238
Query: 1800 ESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
E L +H ++ K+ +A +LE T + ++KL+ F
Sbjct: 1239 EEVLRAH-EEQLKEAQAVPATLPELEA------------TKASLKKLRAQAEAQQPTFDA 1285
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRT 1919
R++ L ++ E L + D E R+ Q L W L + ++ELE
Sbjct: 1286 LRDE-LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQL-- 1342
Query: 1920 EQKEIASEEESPVPLYSHLNSESSIPEELGSP--AVEYVPSESIGQEQPGSPD---HSIL 1974
+++ ES PL + L E++ + A E + QEQ + H
Sbjct: 1343 -GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1401
Query: 1975 TEE--------MICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
EE + ++ E K L + K + GS Q ++ +++H
Sbjct: 1402 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTH- 1459
Query: 2027 HCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQ 2086
SE T+ S I+ + + LR R +L ++Q+ ++ERL
Sbjct: 1460 -------------YSELTTLTSQY---IKFISETLR-RMEEEERLAEQQRAEERERLAEV 1502
Query: 2087 EASLIKQLESYDEFIK-KTEA-----ELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPL 2140
EA+L KQ + + + K +A EL Q ++ + + + ++ + L L
Sbjct: 1503 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562
Query: 2141 HRSETAK---NWKSLTESERSRGSLESIAEHVDASLSGSE--RSVSERSLSAYAKRVNEW 2195
+S A+ + +ERSR +E V L +E R +E L A R E
Sbjct: 1563 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1622
Query: 2196 DSRTEDFQTPSPVLRSSRKIREES 2219
+++ Q + LR R++++ES
Sbjct: 1623 EAQKRQAQEEAERLR--RQVQDES 1644
Score = 39.7 bits (91), Expect = 0.047
Identities = 64/315 (20%), Positives = 125/315 (39%), Gaps = 31/315 (9%)
Query: 358 EAEFQNMSRELYRDLALHFADDISIKEKPAEKSKEKKV-------VKPVRKVQKVAQLSS 410
EAE +EL ++ A +D KE+ A++ E+ + R+++ A+
Sbjct: 2465 EAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521
Query: 411 TECRTGSSHLISTSSWRDGQKLVKKILGPAPRMEPKEQRTASSDRGGRERTAKSGGHIGR 470
+ R + D Q+ K+ A + K RT + + + T I R
Sbjct: 2522 LKLRVAEMSRAQARAEEDAQRFRKQ----AEEIGEKLHRTELATQ--EKVTLVQTLEIQR 2575
Query: 471 AESDPRLDVLHRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRG 530
+SD + L R ER + K + E + +L S Q+E L
Sbjct: 2576 QQSDHDAERL-REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2634
Query: 531 ILDDLQLDSTAHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVIS---- 586
D L +Q+ +L+ A + +R+ ++ V S
Sbjct: 2635 EKDSLL--QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2692
Query: 587 KRRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQE----LYRKQKEAFTK 642
+RR ++ +E VR+++E ++ ++++ Q+E ++N+RL+E L + + A
Sbjct: 2693 RRRQHEAEEG----VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2748
Query: 643 VKNVPPSEPSATRRL 657
+ V S+ +AT+ L
Sbjct: 2749 SEEVTASQVAATKTL 2763
Score = 38.5 bits (88), Expect = 0.10
Identities = 72/383 (18%), Positives = 148/383 (38%), Gaps = 45/383 (11%)
Query: 383 KEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHLISTSSWRDGQ----KLVKKILG 438
+E E ++ + + + ++ +++A+ + R + +++ G+ K +I
Sbjct: 1934 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1993
Query: 439 PAPRMEPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERS------- 491
E + R + D + R + +A+ + RL L + ER
Sbjct: 1994 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 2053
Query: 492 -RSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVE 550
R + + E I L +S E A K L +E+ I + + T + +Q +E
Sbjct: 2054 LRQRRQVEEEILALKASF------EKAAAGKAELELELGRIRSNAE--DTLRSKEQAELE 2105
Query: 551 LQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRK 610
Q+ A R +R + A E+ +++R +EV + + +E R+ +
Sbjct: 2106 AARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRKAALEEVERLKAKVEEARRLR 2162
Query: 611 QNEEKKAQKE---ATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKL--- 664
+ E+++ ++ A E KRLQ ++ AF V E + LQ+ S L
Sbjct: 2163 ERAEQESARQLQLAQEAAQKRLQA--EEKAHAFA----VQQKEQELQQTLQQEQSVLDQL 2216
Query: 665 ----LLEKTLLEEPSHQHVTQETQAKPGYQPSGESDK-----ENKVQERPPSASSSSDMS 715
+ EE V E +A + E+++ E + Q R A ++++
Sbjct: 2217 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-AQAQAAAEKL 2275
Query: 716 LSEPPQPLARKDLMESTWMQPER 738
E Q AR+ E ++ ++
Sbjct: 2276 RKEAEQEAARRAQAEQAALRQKQ 2298
Score = 35.4 bits (80), Expect = 0.89
Identities = 18/58 (31%), Positives = 29/58 (50%)
Query: 647 PPSEPSATRRLQETYSKLLLEKTLLEEPSHQHVTQETQAKPGYQPSGESDKENKVQER 704
PP Q Y + LE+ E P TQ T A+PG +P+ +D+ ++VQ++
Sbjct: 126 PPKRGPLPTEEQRVYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKK 183
Score = 33.1 bits (74), Expect = 4.4
Identities = 61/334 (18%), Positives = 124/334 (37%), Gaps = 44/334 (13%)
Query: 389 KSKEKKVVKPVRKVQKVAQLSST-----ECRTGSSHLISTSSWRDGQKLVKKILGPAPRM 443
K++ + V P +K + + S + RT S L + +S + +K I RM
Sbjct: 1427 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-----QYIKFISETLRRM 1481
Query: 444 EPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERSRSK--SRSENNI 501
E +E+ RER A+ + E +L H + +ER + R + +
Sbjct: 1482 EEEERLAEQQRAEERERLAEVEAAL---EKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1538
Query: 502 KKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVELQNQKSSAPVH 561
+ + D +Q++ + + E++ + + + A + + E + +
Sbjct: 1539 VRREEAAVDAQQQKRS------IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1592
Query: 562 A--------PRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNE 613
R + + + A + KR+ + E + V+ + +RKR+
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1652
Query: 614 EK----KAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKT 669
E KA+ EA +K + LQ L + +A A RRL++ + +
Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQA-----------EEAERRLRQAEVERARQVQ 1701
Query: 670 LLEEPSHQHVTQETQAKPGYQPSGESDKENKVQE 703
+ E + + E Q+K + E +QE
Sbjct: 1702 VALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1735
Score = 32.7 bits (73), Expect = 5.8
Identities = 52/267 (19%), Positives = 107/267 (40%), Gaps = 35/267 (13%)
Query: 2619 SVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKENKDLI-SDATEKV 2677
S +D E L+ E + +Q + +L+ + +V + +E + L S +EK
Sbjct: 2578 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2637
Query: 2678 S-------IAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQL 2730
S I E L+ F +E+ K QQ EE+ + + +E+ +L
Sbjct: 2638 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ------------MEQERQRL 2685
Query: 2731 EAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLG 2790
A ++ + + ++++ + + ++ + QL+Q ++ ++E + NQ L
Sbjct: 2686 VASMEEARRRQHEAEEGVRR------------KQEELQQLEQQRRQQEELLAEENQR-LR 2732
Query: 2791 DDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDEKEEISSPDMCPRPESPVFGASGQEEL 2850
+ + + Q + + + S + L + ++ + P PE F ++
Sbjct: 2733 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS-FDGLRRKVS 2791
Query: 2851 AKRLAELE-LSREFLSALGDDQDWFDE 2876
A+RL E LS E L L DE
Sbjct: 2792 AQRLQEAGILSAEELQRLAQGHTTVDE 2818
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 91.7 bits (226), Expect = 1e-17
Identities = 219/1114 (19%), Positives = 446/1114 (40%), Gaps = 162/1114 (14%)
Query: 1335 YLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALES 1394
Y+ I E++R++ + ER+ A+QQR E L +++A ALE
Sbjct: 1311 YIKFISETLRRMEEEERL------------------AEQQRAEERERLAEVEA---ALEK 1349
Query: 1395 QRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCK-----IAAQQSETA------- 1442
QRQL A+ HA++ Q + +E+ + +QE + + AQQ + +
Sbjct: 1350 QRQL-------AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1402
Query: 1443 -RLTTDA-----ARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTR- 1495
R +++A ARQ E AE +R I + + L + QR ++ LR R
Sbjct: 1403 LRQSSEAEIQAKARQ-AEAAERSRLRIEEEIRVVRLQLEAT-ERQRGGAEGELQALRARA 1460
Query: 1496 --TETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPS 1553
E ++ + + D +K A + S R E
Sbjct: 1461 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1520
Query: 1554 VPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDES 1613
+ +E E++L ++E + QVQ A + + RS + + + E + + + S
Sbjct: 1521 L-QAEEAERRLRQAEVERA--RQVQVALETAQRSAEA----ELQSKRASFAEKTAQLERS 1573
Query: 1614 MTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQ 1673
+ E+ + R + ++ E+ R + E E+ L + L + +
Sbjct: 1574 LQEEHVAVAQLREEAERRAQQQAEAERAR-----EEAERELERWQLKANEALRLRLQAEE 1628
Query: 1674 DSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGED 1733
+ K + + KEE R A + + E+A++++ ELA E +K+ R E
Sbjct: 1629 VAQQKSLAQAEAEKQKEEAEREARRRG--KAEEQAVRQR---ELAEQELEKQ--RQLAEG 1681
Query: 1734 DKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQE 1793
L +Q + LR + E+ E +R + AR +R+ Q+ +++ K++
Sbjct: 1682 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR-QELEAELAKVRA 1740
Query: 1794 KLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRM 1853
+++ SK + ++++++ S + E ++ ++ ++ ++ K+ R
Sbjct: 1741 EMEVLLASK--ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-- 1796
Query: 1854 DEKFLTKREQKLMQRRQHAEELLEWKRRLDAE------EAEIRQMEKQALAAWDKELIKP 1907
E+ ++R AE +L K E EAEI EK+A + L +
Sbjct: 1797 ------LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1850
Query: 1908 KT-PKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQP 1966
+ ++ LE+Q + K A EE L +SE + Q
Sbjct: 1851 EAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSEL--------------------ERQK 1888
Query: 1967 GSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
G ++ + + +++E K S K+ ++ E G R+ + L K
Sbjct: 1889 G-----LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1943
Query: 2027 HCYSWSDESLSMTQSETTSDQSD-IEGRIRALKDELRKRKSVVNQL-----KKEQKKRQK 2080
+ L+ + + + ++ + A ++ R+RK+ + ++ K E+ +R +
Sbjct: 1944 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2003
Query: 2081 ERLK---------AQEASLIKQLESYDE----FIKKTEAELSQDLETSPTAKPQIKTLSS 2127
ER + AQEA+ K+L++ ++ +++ E EL Q L+ + Q++ +
Sbjct: 2004 ERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2062
Query: 2128 ASEK--PKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSL 2185
A+ + + + E A++ + + E+ER + S E A+ + + +E+ E
Sbjct: 2063 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122
Query: 2186 SAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREES----GDSLENVPALHL-LKELNATSR 2240
A A+R + Q + +K E++ + + L L L+E +
Sbjct: 2123 EA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2181
Query: 2241 ILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVL--LKLVLEQGDSSEIL 2298
+LD E ++ + + E + + E+ FS + + L LK +E + + IL
Sbjct: 2182 LLD-------EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2234
Query: 2299 SKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKE 2358
KD N Q+ L A + +EE + + Q+ + + +D+ +Q+ E
Sbjct: 2235 RDKD------NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAE 2287
Query: 2359 KDLSWSEHLFAPKEIP-YSEDFEVSSFKKEISAE 2391
K L E + A +E + E+ +KE++ E
Sbjct: 2288 KML--KEKMQAVQEATRLKAEAELLQQQKELAQE 2319
Score = 73.6 bits (179), Expect = 3e-12
Identities = 227/1261 (18%), Positives = 480/1261 (38%), Gaps = 182/1261 (14%)
Query: 1339 IEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
I+ RQ ER R + + ++ V Q+ ++QR + L L+A E E+Q+
Sbjct: 1411 IQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK-- 1467
Query: 1399 EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAEL 1458
+ AQ AE L++ VQ + ++ ++A ++A++ A + R + + EL
Sbjct: 1468 -----RQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1519
Query: 1459 TRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSK 1518
R +A RQ + +Q++ ET ++S L QSK + K
Sbjct: 1520 -RLQAEEAE-----------RRLRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAEK 1566
Query: 1519 HQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQ 1578
+ S + R + ++Q++ + + +E E++L +++++ +++
Sbjct: 1567 TAQLERSLQEEHVAVAQL---REEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1623
Query: 1579 TAADDSLRSDSVPSLPDEKDSTSI---------ATEYSLKFDESMTEDEIEEQSFRSLLP 1629
A++ + S+ EK A E +++ E + E E+E+Q R L
Sbjct: 1624 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE-LAEQELEKQ--RQLAE 1680
Query: 1630 SESHRRFNMEKRRGHHDDSDEEASPEKTTLSTA-KELNMPFSGGQDSFSKFTMEM--VRQ 1686
+ +R E+ E+ ++ L L + + E+ VR
Sbjct: 1681 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1740
Query: 1687 YMK---------EEEMRAAHQSSLLRLREKALKEKTKAE----LAWLEHQKKHLRDKGED 1733
M+ EEE R+ + S RL +A + + AE L L + K R E+
Sbjct: 1741 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1800
Query: 1734 DKMPPLRKKQRGLLLRLQQ--EKAEIKRLQEA---NKAARKERQLILKQQEEIEKIRQTT 1788
D + +R L +L E +K E K A ER L + E ++ R
Sbjct: 1801 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1860
Query: 1789 IKLQEK---------LKSAGESKLDSHS---DDDTKDNKATSPGPTDLETRSPSPISISS 1836
Q K L+ A +S+L+ +D + + L+ + ++
Sbjct: 1861 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK----ASFEKAA 1916
Query: 1837 SETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEE-------AEI 1889
+ + + +L ++RS ++ +K + +L RQ E +RR +AEE AE
Sbjct: 1917 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1976
Query: 1890 RQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELG 1949
++ A + E +K K + +R EQ+ + + L +E
Sbjct: 1977 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK------ 2030
Query: 1950 SPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSK 2009
+ + +Q L +E +L ++ + ++ +E+
Sbjct: 2031 --------AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA------EEARV 2076
Query: 2010 GSHRTGGQCHLPIKSHQHC-YSWSDESLSMTQSETTSD------QSDIEGRIRALKDELR 2062
+ R Q ++ + S +++ + Q++ ++ + + R +A + LR
Sbjct: 2077 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2136
Query: 2063 KRKSVVNQLKK-----EQKKRQKERLKAQEASLIKQLES-------YDEFIKKTEAEL-- 2108
++++ +++K EQ RQK +++ + +L QLE DE +++ +AE
Sbjct: 2137 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2196
Query: 2109 -----SQDLETSPTAKPQIKTLSSASEKPKI---------KPLTPLHRSETAKNWKSLTE 2154
SQ E + + Q++ LS + + K T E A+ K + E
Sbjct: 2197 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2256
Query: 2155 -------SERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSP 2207
+ + L +AE A +R+++E+ L + V E + +
Sbjct: 2257 EAARLSVAAQEAARLRQLAEEDLA----QQRALAEKMLKEKMQAVQE----ATRLKAEAE 2308
Query: 2208 VLRSSRKIREESGDSLE---NVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYT 2264
+L+ +++ +E L+ A L +E R L+ + E S ++E ++
Sbjct: 2309 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2368
Query: 2265 KLKKSKI---EDA--FSKEGK--SDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
++ +++ EDA F K+ + + L + L + ++ ++ + + +
Sbjct: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428
Query: 2318 AIENLHKSEEMLKERQS--DQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPY 2375
AI L + +E L++ +Q + + E + ++ LS + L +
Sbjct: 2429 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2488
Query: 2376 SEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEI 2435
E ++ +L++D+ + L + Q + + + R S + E
Sbjct: 2489 QEKAKLE--------QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2540
Query: 2436 SECLSEKSLSIHSNVHSDRLLE---------LKSPTELMKSKERSDVEHEQQVTESPSLA 2486
E + K + R E L+ +L++ + R+ + H ++VT S A
Sbjct: 2541 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2600
Query: 2487 S 2487
+
Sbjct: 2601 T 2601
Score = 73.6 bits (179), Expect = 3e-12
Identities = 180/910 (19%), Positives = 377/910 (41%), Gaps = 99/910 (10%)
Query: 1341 ESVRQLSDVERVRGISLAQQESV--SLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
E +Q + E R LA++ + +LA+ K Q+Q E D A + +AE+ E +
Sbjct: 1761 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1820
Query: 1399 EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAEL 1458
E + ++ +++R + + ++ + + + A+ D ++ ++ +
Sbjct: 1821 GEATRLKTEAEIALKEKEAENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK- 1878
Query: 1459 TRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTE---TDRKSPSVSLSQSKEGTL 1515
SD+ + L QR+ + + + L+ E + + L + +
Sbjct: 1879 ----ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1934
Query: 1516 DSKHQKYSASYDSYSESSGYKNHDRRSSSGSSR-QESPSVPSCKENEKKLNGEKIE---S 1571
D+ K A ++ + +RR R Q+S + ++K E++E +
Sbjct: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1994
Query: 1572 SIDEQVQTAADDSLRSDSVPSLPDEKDSTSI-ATEYSLKFDESMTEDEI-----EEQSFR 1625
++E + S L E + A E + F E E+ +EQS
Sbjct: 1995 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2054
Query: 1626 SLLPSESH-RRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMV 1684
L E+ R E+ ++ EA+ + + A+ L S + + ++ +
Sbjct: 2055 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ--SAEEQAQARAQAQAA 2112
Query: 1685 RQYM-KEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQK---KHLRDKGEDDKMPPLR 1740
+ + KE E AA ++ + + AL++K A+ +H+K + LR K +
Sbjct: 2113 AEKLRKEAEQEAARRA---QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ-------- 2161
Query: 1741 KKQRGLLLRLQQEKA---------EIKRLQ-EANKAARKERQLILKQQEEIEKIRQTTIK 1790
+Q LRLQ E+ E++RL+ EA +AAR+ Q+ +EE+ +R +
Sbjct: 2162 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV----EEELFSVRVQMEE 2217
Query: 1791 LQEKLKSAGESK---LDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLK 1847
L KLK+ E++ L D+T+ + +S+++ E + + Q +
Sbjct: 2218 L-SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2276
Query: 1848 K---MRSRMDEKFLTKREQKLMQ--RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDK 1902
+ + + EK L ++ Q + + R + ELL+ ++ L E+A Q +K+ +A
Sbjct: 2277 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2336
Query: 1903 ELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIG 1962
E + + ++ LE +R Q E+++E E + ++ + EE + +E IG
Sbjct: 2337 E--ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK--QAEEIG 2392
Query: 1963 QEQPGSPDHSILTEEMI-CSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLP 2021
++ + + T+E + Q LE S H + ++++ E K + + L
Sbjct: 2393 EKLHRT---ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-LQ 2448
Query: 2022 IKSHQHCYSWSDESLSMTQS---ETTSDQSDIEGRIRALKDELRKRKSV-------VNQL 2071
+KS + ++ L TQ+ S++ + R R ++ E K + + QL
Sbjct: 2449 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2508
Query: 2072 KKEQKKRQ------KERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTL 2125
++EQ+++Q ++RL A ++ +E +++ + EL Q LE + ++
Sbjct: 2509 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-QQLEQQRRQQEELLAE 2567
Query: 2126 SSASEKPKIKPLTPLHRSETAKNWKSLTESE--------RSRGSLESIAEHVDA--SLSG 2175
+ + +++ L HR+ A + + +T S+ R +L+ A + S G
Sbjct: 2568 ENQRLREQLQLLEEQHRAALAHS-EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDG 2626
Query: 2176 SERSVSERSL 2185
R VS + L
Sbjct: 2627 LRRKVSAQRL 2636
Score = 62.8 bits (151), Expect = 5e-09
Identities = 154/835 (18%), Positives = 304/835 (36%), Gaps = 132/835 (15%)
Query: 1136 EDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSSTSSKGK---------KGKKEKTEWLD 1186
E+ R+ A + + ++ + Q A+ K K + ++E L
Sbjct: 1956 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2015
Query: 1187 SFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTD-STLEDLSGHSVSVSS 1245
Q L EEKA + Q K+ ++ +QTL + S L+ L G + +
Sbjct: 2016 LAQEAAQKRLQAEEKAHAFAVQQKE---------QELQQTLQQEQSVLDQLRGEAEAARR 2066
Query: 1246 DKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASR 1305
+++ ++Q Q + A ER K S + A L A +
Sbjct: 2067 AAEEAEEARVQAEREAAQSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122
Query: 1306 TTTENMAPIPGSKRFSPAGLHHRMAAELS---YLNAIEESVRQLSDVER-VRGISLAQQE 1361
+ A L + AA+ + E+++RQ + VE+ + + L +E
Sbjct: 2123 EAARRA-------QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2175
Query: 1362 SVSLAQIIKAQQQR---HERDLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQ 1418
+ ++ + QR + A + + E+E + Q+EE A++ AE+ +++
Sbjct: 2176 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2235
Query: 1419 SQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELTRTHISDAVVASGAPLAILY 1478
+ LQE K+ E ARL+ AA++ + +L ++ A+
Sbjct: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSV-AAQEAARLRQLAEEDLAQ-------QRALAE 2287
Query: 1479 DHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNH 1538
++ + + R + E + L+Q + L + K + E+ G+
Sbjct: 2288 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL--QEDKEQMAQQLAEETQGF--- 2342
Query: 1539 DRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKD 1598
Q + ++ E E+++ + E + A
Sbjct: 2343 ----------QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR---------------- 2376
Query: 1599 STSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRF--NMEKRRGHHDDSDEEASPEK 1656
A E + +F + +EI E+ R+ L ++ +E +R D E
Sbjct: 2377 ----AEEDAQRFRKQ--AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2430
Query: 1657 TTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLR----LREKALKEK 1712
L KE K E +K EEM+ Q LL+ L++ L EK
Sbjct: 2431 AELEREKE-------------KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2477
Query: 1713 TK--AELAWLEHQKKHLRDKGEDD--KMPPLRKKQRGLLLRLQQEKAE-IKRLQEANKAA 1767
++E +K L +D+ K LR++Q+ +++QE+ + ++EA +
Sbjct: 2478 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2537
Query: 1768 RKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLD--------------SHSDDDTKD 1813
+ + + ++QEE++++ Q + QE+L + +L +HS++ T
Sbjct: 2538 HEAEEGVRRKQEELQQLEQQR-RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2596
Query: 1814 NKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKRE--QKLMQ---- 1867
A + + P + + E S + K R+ E + E Q+L Q
Sbjct: 2597 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTT 2656
Query: 1868 -----RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQ 1917
RR+ L+ + + + + AA ++L+ P T LE Q
Sbjct: 2657 VDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2711
Score = 58.2 bits (139), Expect = 1e-07
Identities = 132/715 (18%), Positives = 300/715 (41%), Gaps = 88/715 (12%)
Query: 1683 MVRQYMK--EEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLR 1740
+ QY+K E +R + L +++A + + AE+ +++ L + K R
Sbjct: 1307 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1366
Query: 1741 KKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTT-IKLQEKLKSAG 1799
+ + L R+Q+E + R +EA A+++++ I QEE++++RQ++ ++Q K + A
Sbjct: 1367 EAKE-LQQRMQEE---VVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQAE 1419
Query: 1800 ESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
++ ++ T+ + R + + + + + +K +++ + + L
Sbjct: 1420 AAERSRLRIEEEIRVVRLQLEATERQ-RGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1478
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRT 1919
++ Q QR++ AE L + + +AE A +Q QAL + + + ++ E +R
Sbjct: 1479 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1538
Query: 1920 EQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMI 1979
Q ++A E ++ S EL S + E+ + S+ E +
Sbjct: 1539 RQVQVALE-----------TAQRSAEAELQSKRASFA-------EKTAQLERSLQEEHVA 1580
Query: 1980 CSQ-ELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSM 2038
+Q E+ + + + +++E + + L +++ + +SL+
Sbjct: 1581 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA---QQKSLAQ 1637
Query: 2039 TQSETTSDQSDIEGRIRALKDE--LRKRKSVVNQLKKEQKKRQ---KERLKAQEASLIKQ 2093
++E ++++ E R R +E +R+R+ +L+K+++ + ++RL A++ + +
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1697
Query: 2094 LESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLT 2153
E+ + E + L A+ Q + ++ ++ +++ R+E
Sbjct: 1698 AET-------EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE--------- 1741
Query: 2154 ESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSR 2213
L S A + S S SE+ S++ L A A R E + + + R
Sbjct: 1742 ----MEVLLASKARAEEESRSTSEK--SKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1795
Query: 2214 KIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSK---KSEI----KEIEYTKL 2266
++ EE ++ R+L +GE+++ ++EI KE E +L
Sbjct: 1796 QLAEEDA-----------ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1844
Query: 2267 KKSKIEDAFSK--------EGKSDVLLKLV-LEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
++ ++AF + + K+D+ +L L + SE+ +K L D+ Q+ V
Sbjct: 1845 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-QRRQVEE 1903
Query: 2318 AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKE 2372
I L S E +++ ++ + +D K E + + L A +E
Sbjct: 1904 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1958
Score = 47.8 bits (112), Expect = 2e-04
Identities = 245/1386 (17%), Positives = 511/1386 (36%), Gaps = 225/1386 (16%)
Query: 1739 LRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLI-----LKQQEEIEKIRQTTIKLQE 1793
LR+ + L QQ E +RL E A K+RQL K Q E E ++ ++QE
Sbjct: 1319 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA-KELQQRMQE 1377
Query: 1794 KLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRM 1853
++ E+ +D+ + ++ L S + I + + + ++ R R+
Sbjct: 1378 EVVRREEAAVDAQ-----QQKRSIQEELQQLRQSSEAEIQAKARQAEAA----ERSRLRI 1428
Query: 1854 DEKFLTKREQKLMQRRQH--AEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPK 1911
+E+ R Q RQ AE L+ R AEEAE ++ + Q A + ++ ++ +
Sbjct: 1429 EEEIRVVRLQLEATERQRGGAEGELQ-ALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487
Query: 1912 K-----ELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEE-LGSPAVEYVPSESIGQEQ 1965
K EL + + E A E++ + L ++ E L VE + E
Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE- 1546
Query: 1966 PGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSH 2025
T + EL+S + + S+ ++ + R ++
Sbjct: 1547 ---------TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE--------EAE 1589
Query: 2026 QHCYSWSDESLSMTQSETTSDQSDIEG----RIRALKDELRKRKSVVN---QLKKEQKKR 2078
+ ++ + ++E ++ ++ R+R +E+ ++KS+ + +KE+ +R
Sbjct: 1590 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1649
Query: 2079 QKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLT 2138
+ R E ++Q E ++ ++K + A+ ++ L + +E+ + +
Sbjct: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ--R 1707
Query: 2139 PLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSR 2198
L E A+ + + + R LE+ V A + E L++ A+ E S
Sbjct: 1708 QLLEEELARLQREAAAATQKRQELEAELAKVRAEM--------EVLLASKARAEEESRST 1759
Query: 2199 TEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEI 2258
+E +S +++ E+G E L E A R L E+ ++ ++
Sbjct: 1760 SE---------KSKQRLEAEAGRFRE-------LAEEAARLRAL------AEEAKRQRQL 1797
Query: 2259 KEIEYTKLKKSKIEDAFSKEGKSD-VLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
E EDA + +++ VL + + G+++ + ++ ++ L + + +
Sbjct: 1798 AE-----------EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE---- 1842
Query: 2318 AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSE 2377
+ L + E + R +Q H DI E+
Sbjct: 1843 RLRRLAEDEAFQRRRLEEQAAQHKA------DIEER------------------------ 1872
Query: 2378 DFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNE---E 2434
++ +K +EL + V L R+ + ++ +++S A + G E E
Sbjct: 1873 ---LAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKASFEKAAA-GKAELELE 1925
Query: 2435 ISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESPSLASVPTADEL 2494
+ S ++ S ++ LE +L +ER E E++V +S +
Sbjct: 1926 LGRIRSNAEDTLRSKEQAE--LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1983
Query: 2495 FDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKH 2554
+R+ + LR + E A+ E + + +EK
Sbjct: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR------------LQAEEKA 2031
Query: 2555 GIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYE 2614
FA QK E Q QEQ+ + + E + + E
Sbjct: 2032 HAFAVQQK---------------------EQELQQTLQQEQSVLDQLRG-EAEAARRAAE 2069
Query: 2615 KSLPSVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKE-NKDLISDA 2673
++ + E +SR E + ++ A Q+ +Q ++++ K+ +A
Sbjct: 2070 EAEEARVQAEREAAQSRRQVEEAERLKQ-----SAEEQAQARAQAQAAAEKLRKEAEQEA 2124
Query: 2674 TEKVSIAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLL---------DLLT 2724
+ E+EK ++F E+ A+ ++L T L +LL
Sbjct: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
Query: 2725 REKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLS 2784
E +L+A+ + + + +++L + + + L K+ + I + +D +
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2244
Query: 2785 NQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDE--------KEEISSPDMCPR 2836
+E + K+V + +V Q + +L + KE++ + R
Sbjct: 2245 QEE--AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302
Query: 2837 PESPVFGASGQEELAKRLA-ELELSREFLSALGDDQDWFDEDFGLSSSHKIQKNKAEETI 2895
++ Q+ELA+ A L+ +E ++ Q +E G + + ++ + E
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMA-----QQLAEETQGFQRTLEAERQRQLE-- 2355
Query: 2896 VPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKELGHDLHSISIPTKLLG 2955
+ AE +R+ + E A E+ + A +E+G LH + T+
Sbjct: 2356 --MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLHRTELATQEKV 2406
Query: 2956 CASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMKPCRINSSYFRRVKNP 3015
+ L+I+ R + +E E+ E L Q K ++ S + V+
Sbjct: 2407 TLVQTLEIQ----RQQSDHDAERLREAIAELEREKEKLQQEA--KLLQLKSEEMQTVQQE 2460
Query: 3016 NNLDEIKSFIASEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVDHILVQELHEEEAQWV 3075
L E ++ S + + SL + + Q+ K + +D V Q+L EE+ +
Sbjct: 2461 QLLQETQALQQSFLSEKDSLLQ--RERFIEQEKAKLEQLFQDEV--AKAQQLREEQQRQQ 2516
Query: 3076 NYDEDE 3081
E E
Sbjct: 2517 QQMEQE 2522
Score = 47.4 bits (111), Expect = 2e-04
Identities = 109/504 (21%), Positives = 195/504 (38%), Gaps = 71/504 (14%)
Query: 1749 RLQQEKAEIKRLQEANKAA---RKERQLILKQQEEIEKI------RQTTIKLQEKLKSAG 1799
RL E ++ L E + AA R E +L L + E++ + + TI L +
Sbjct: 1020 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1079
Query: 1800 ESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
E L +H ++ K+ +A +LE T + ++KL+ F
Sbjct: 1080 EEVLRAH-EEQLKEAQAVPATLPELEA------------TKASLKKLRAQAEAQQPTFDA 1126
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRT 1919
R++ L ++ E L + D E R+ Q L W L + ++ELE
Sbjct: 1127 LRDE-LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQL-- 1183
Query: 1920 EQKEIASEEESPVPLYSHLNSESSIPEELGSP--AVEYVPSESIGQEQPGSPD---HSIL 1974
+++ ES PL + L E++ + A E + QEQ + H
Sbjct: 1184 -GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1242
Query: 1975 TEE--------MICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
EE + ++ E K L + K + GS Q ++ +++H
Sbjct: 1243 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTH- 1300
Query: 2027 HCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQ 2086
SE T+ S I+ + + LR R +L ++Q+ ++ERL
Sbjct: 1301 -------------YSELTTLTSQY---IKFISETLR-RMEEEERLAEQQRAEERERLAEV 1343
Query: 2087 EASLIKQLESYDEFIK-KTEA-----ELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPL 2140
EA+L KQ + + + K +A EL Q ++ + + + ++ + L L
Sbjct: 1344 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403
Query: 2141 HRSETAK---NWKSLTESERSRGSLESIAEHVDASLSGSE--RSVSERSLSAYAKRVNEW 2195
+S A+ + +ERSR +E V L +E R +E L A R E
Sbjct: 1404 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1463
Query: 2196 DSRTEDFQTPSPVLRSSRKIREES 2219
+++ Q + LR R++++ES
Sbjct: 1464 EAQKRQAQEEAERLR--RQVQDES 1485
Score = 39.7 bits (91), Expect = 0.047
Identities = 64/315 (20%), Positives = 125/315 (39%), Gaps = 31/315 (9%)
Query: 358 EAEFQNMSRELYRDLALHFADDISIKEKPAEKSKEKKV-------VKPVRKVQKVAQLSS 410
EAE +EL ++ A +D KE+ A++ E+ + R+++ A+
Sbjct: 2306 EAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362
Query: 411 TECRTGSSHLISTSSWRDGQKLVKKILGPAPRMEPKEQRTASSDRGGRERTAKSGGHIGR 470
+ R + D Q+ K+ A + K RT + + + T I R
Sbjct: 2363 LKLRVAEMSRAQARAEEDAQRFRKQ----AEEIGEKLHRTELATQ--EKVTLVQTLEIQR 2416
Query: 471 AESDPRLDVLHRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRG 530
+SD + L R ER + K + E + +L S Q+E L
Sbjct: 2417 QQSDHDAERL-REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2475
Query: 531 ILDDLQLDSTAHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVIS---- 586
D L +Q+ +L+ A + +R+ ++ V S
Sbjct: 2476 EKDSLL--QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2533
Query: 587 KRRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQE----LYRKQKEAFTK 642
+RR ++ +E VR+++E ++ ++++ Q+E ++N+RL+E L + + A
Sbjct: 2534 RRRQHEAEEG----VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2589
Query: 643 VKNVPPSEPSATRRL 657
+ V S+ +AT+ L
Sbjct: 2590 SEEVTASQVAATKTL 2604
Score = 38.5 bits (88), Expect = 0.10
Identities = 72/383 (18%), Positives = 148/383 (38%), Gaps = 45/383 (11%)
Query: 383 KEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHLISTSSWRDGQ----KLVKKILG 438
+E E ++ + + + ++ +++A+ + R + +++ G+ K +I
Sbjct: 1775 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1834
Query: 439 PAPRMEPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERS------- 491
E + R + D + R + +A+ + RL L + ER
Sbjct: 1835 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1894
Query: 492 -RSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVE 550
R + + E I L +S E A K L +E+ I + + T + +Q +E
Sbjct: 1895 LRQRRQVEEEILALKASF------EKAAAGKAELELELGRIRSNAE--DTLRSKEQAELE 1946
Query: 551 LQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRK 610
Q+ A R +R + A E+ +++R +EV + + +E R+ +
Sbjct: 1947 AARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRKAALEEVERLKAKVEEARRLR 2003
Query: 611 QNEEKKAQKE---ATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKL--- 664
+ E+++ ++ A E KRLQ ++ AF V E + LQ+ S L
Sbjct: 2004 ERAEQESARQLQLAQEAAQKRLQA--EEKAHAFA----VQQKEQELQQTLQQEQSVLDQL 2057
Query: 665 ----LLEKTLLEEPSHQHVTQETQAKPGYQPSGESDK-----ENKVQERPPSASSSSDMS 715
+ EE V E +A + E+++ E + Q R A ++++
Sbjct: 2058 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-AQAQAAAEKL 2116
Query: 716 LSEPPQPLARKDLMESTWMQPER 738
E Q AR+ E ++ ++
Sbjct: 2117 RKEAEQEAARRAQAEQAALRQKQ 2139
Score = 33.1 bits (74), Expect = 4.4
Identities = 61/334 (18%), Positives = 124/334 (37%), Gaps = 44/334 (13%)
Query: 389 KSKEKKVVKPVRKVQKVAQLSST-----ECRTGSSHLISTSSWRDGQKLVKKILGPAPRM 443
K++ + V P +K + + S + RT S L + +S + +K I RM
Sbjct: 1268 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-----QYIKFISETLRRM 1322
Query: 444 EPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERSRSK--SRSENNI 501
E +E+ RER A+ + E +L H + +ER + R + +
Sbjct: 1323 EEEERLAEQQRAEERERLAEVEAAL---EKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1379
Query: 502 KKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVELQNQKSSAPVH 561
+ + D +Q++ + + E++ + + + A + + E + +
Sbjct: 1380 VRREEAAVDAQQQKRS------IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1433
Query: 562 A--------PRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNE 613
R + + + A + KR+ + E + V+ + +RKR+
Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1493
Query: 614 EK----KAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKT 669
E KA+ EA +K + LQ L + +A A RRL++ + +
Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRLQA-----------EEAERRLRQAEVERARQVQ 1542
Query: 670 LLEEPSHQHVTQETQAKPGYQPSGESDKENKVQE 703
+ E + + E Q+K + E +QE
Sbjct: 1543 VALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1576
Score = 32.7 bits (73), Expect = 5.8
Identities = 52/267 (19%), Positives = 107/267 (40%), Gaps = 35/267 (13%)
Query: 2619 SVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKENKDLI-SDATEKV 2677
S +D E L+ E + +Q + +L+ + +V + +E + L S +EK
Sbjct: 2419 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2478
Query: 2678 S-------IAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQL 2730
S I E L+ F +E+ K QQ EE+ + + +E+ +L
Sbjct: 2479 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ------------MEQERQRL 2526
Query: 2731 EAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLG 2790
A ++ + + ++++ + + ++ + QL+Q ++ ++E + NQ L
Sbjct: 2527 VASMEEARRRQHEAEEGVRR------------KQEELQQLEQQRRQQEELLAEENQR-LR 2573
Query: 2791 DDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDEKEEISSPDMCPRPESPVFGASGQEEL 2850
+ + + Q + + + S + L + ++ + P PE F ++
Sbjct: 2574 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS-FDGLRRKVS 2632
Query: 2851 AKRLAELE-LSREFLSALGDDQDWFDE 2876
A+RL E LS E L L DE
Sbjct: 2633 AQRLQEAGILSAEELQRLAQGHTTVDE 2659
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 91.7 bits (226), Expect = 1e-17
Identities = 219/1114 (19%), Positives = 446/1114 (40%), Gaps = 162/1114 (14%)
Query: 1335 YLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALES 1394
Y+ I E++R++ + ER+ A+QQR E L +++A ALE
Sbjct: 1319 YIKFISETLRRMEEEERL------------------AEQQRAEERERLAEVEA---ALEK 1357
Query: 1395 QRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCK-----IAAQQSETA------- 1442
QRQL A+ HA++ Q + +E+ + +QE + + AQQ + +
Sbjct: 1358 QRQL-------AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1410
Query: 1443 -RLTTDA-----ARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTR- 1495
R +++A ARQ E AE +R I + + L + QR ++ LR R
Sbjct: 1411 LRQSSEAEIQAKARQ-AEAAERSRLRIEEEIRVVRLQLEAT-ERQRGGAEGELQALRARA 1468
Query: 1496 --TETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPS 1553
E ++ + + D +K A + S R E
Sbjct: 1469 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1528
Query: 1554 VPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDES 1613
+ +E E++L ++E + QVQ A + + RS + + + E + + + S
Sbjct: 1529 L-QAEEAERRLRQAEVERA--RQVQVALETAQRSAEA----ELQSKRASFAEKTAQLERS 1581
Query: 1614 MTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQ 1673
+ E+ + R + ++ E+ R + E E+ L + L + +
Sbjct: 1582 LQEEHVAVAQLREEAERRAQQQAEAERAR-----EEAERELERWQLKANEALRLRLQAEE 1636
Query: 1674 DSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGED 1733
+ K + + KEE R A + + E+A++++ ELA E +K+ R E
Sbjct: 1637 VAQQKSLAQAEAEKQKEEAEREARRRG--KAEEQAVRQR---ELAEQELEKQ--RQLAEG 1689
Query: 1734 DKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQE 1793
L +Q + LR + E+ E +R + AR +R+ Q+ +++ K++
Sbjct: 1690 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR-QELEAELAKVRA 1748
Query: 1794 KLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRM 1853
+++ SK + ++++++ S + E ++ ++ ++ ++ K+ R
Sbjct: 1749 EMEVLLASK--ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-- 1804
Query: 1854 DEKFLTKREQKLMQRRQHAEELLEWKRRLDAE------EAEIRQMEKQALAAWDKELIKP 1907
E+ ++R AE +L K E EAEI EK+A + L +
Sbjct: 1805 ------LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1858
Query: 1908 KT-PKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQP 1966
+ ++ LE+Q + K A EE L +SE + Q
Sbjct: 1859 EAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSEL--------------------ERQK 1896
Query: 1967 GSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
G ++ + + +++E K S K+ ++ E G R+ + L K
Sbjct: 1897 G-----LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1951
Query: 2027 HCYSWSDESLSMTQSETTSDQSD-IEGRIRALKDELRKRKSVVNQL-----KKEQKKRQK 2080
+ L+ + + + ++ + A ++ R+RK+ + ++ K E+ +R +
Sbjct: 1952 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2011
Query: 2081 ERLK---------AQEASLIKQLESYDE----FIKKTEAELSQDLETSPTAKPQIKTLSS 2127
ER + AQEA+ K+L++ ++ +++ E EL Q L+ + Q++ +
Sbjct: 2012 ERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2070
Query: 2128 ASEK--PKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSL 2185
A+ + + + E A++ + + E+ER + S E A+ + + +E+ E
Sbjct: 2071 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130
Query: 2186 SAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREES----GDSLENVPALHL-LKELNATSR 2240
A A+R + Q + +K E++ + + L L L+E +
Sbjct: 2131 EA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2189
Query: 2241 ILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVL--LKLVLEQGDSSEIL 2298
+LD E ++ + + E + + E+ FS + + L LK +E + + IL
Sbjct: 2190 LLD-------EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2242
Query: 2299 SKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKE 2358
KD N Q+ L A + +EE + + Q+ + + +D+ +Q+ E
Sbjct: 2243 RDKD------NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAE 2295
Query: 2359 KDLSWSEHLFAPKEIP-YSEDFEVSSFKKEISAE 2391
K L E + A +E + E+ +KE++ E
Sbjct: 2296 KML--KEKMQAVQEATRLKAEAELLQQQKELAQE 2327
Score = 73.6 bits (179), Expect = 3e-12
Identities = 227/1261 (18%), Positives = 480/1261 (38%), Gaps = 182/1261 (14%)
Query: 1339 IEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
I+ RQ ER R + + ++ V Q+ ++QR + L L+A E E+Q+
Sbjct: 1419 IQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK-- 1475
Query: 1399 EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAEL 1458
+ AQ AE L++ VQ + ++ ++A ++A++ A + R + + EL
Sbjct: 1476 -----RQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1527
Query: 1459 TRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSK 1518
R +A RQ + +Q++ ET ++S L QSK + K
Sbjct: 1528 -RLQAEEAE-----------RRLRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAEK 1574
Query: 1519 HQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQ 1578
+ S + R + ++Q++ + + +E E++L +++++ +++
Sbjct: 1575 TAQLERSLQEEHVAVAQL---REEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1631
Query: 1579 TAADDSLRSDSVPSLPDEKDSTSI---------ATEYSLKFDESMTEDEIEEQSFRSLLP 1629
A++ + S+ EK A E +++ E + E E+E+Q R L
Sbjct: 1632 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE-LAEQELEKQ--RQLAE 1688
Query: 1630 SESHRRFNMEKRRGHHDDSDEEASPEKTTLSTA-KELNMPFSGGQDSFSKFTMEM--VRQ 1686
+ +R E+ E+ ++ L L + + E+ VR
Sbjct: 1689 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1748
Query: 1687 YMK---------EEEMRAAHQSSLLRLREKALKEKTKAE----LAWLEHQKKHLRDKGED 1733
M+ EEE R+ + S RL +A + + AE L L + K R E+
Sbjct: 1749 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1808
Query: 1734 DKMPPLRKKQRGLLLRLQQ--EKAEIKRLQEA---NKAARKERQLILKQQEEIEKIRQTT 1788
D + +R L +L E +K E K A ER L + E ++ R
Sbjct: 1809 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1868
Query: 1789 IKLQEK---------LKSAGESKLDSHS---DDDTKDNKATSPGPTDLETRSPSPISISS 1836
Q K L+ A +S+L+ +D + + L+ + ++
Sbjct: 1869 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK----ASFEKAA 1924
Query: 1837 SETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEE-------AEI 1889
+ + + +L ++RS ++ +K + +L RQ E +RR +AEE AE
Sbjct: 1925 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1984
Query: 1890 RQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELG 1949
++ A + E +K K + +R EQ+ + + L +E
Sbjct: 1985 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK------ 2038
Query: 1950 SPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSK 2009
+ + +Q L +E +L ++ + ++ +E+
Sbjct: 2039 --------AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA------EEARV 2084
Query: 2010 GSHRTGGQCHLPIKSHQHC-YSWSDESLSMTQSETTSD------QSDIEGRIRALKDELR 2062
+ R Q ++ + S +++ + Q++ ++ + + R +A + LR
Sbjct: 2085 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2144
Query: 2063 KRKSVVNQLKK-----EQKKRQKERLKAQEASLIKQLES-------YDEFIKKTEAEL-- 2108
++++ +++K EQ RQK +++ + +L QLE DE +++ +AE
Sbjct: 2145 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2204
Query: 2109 -----SQDLETSPTAKPQIKTLSSASEKPKI---------KPLTPLHRSETAKNWKSLTE 2154
SQ E + + Q++ LS + + K T E A+ K + E
Sbjct: 2205 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2264
Query: 2155 -------SERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSP 2207
+ + L +AE A +R+++E+ L + V E + +
Sbjct: 2265 EAARLSVAAQEAARLRQLAEEDLA----QQRALAEKMLKEKMQAVQE----ATRLKAEAE 2316
Query: 2208 VLRSSRKIREESGDSLE---NVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYT 2264
+L+ +++ +E L+ A L +E R L+ + E S ++E ++
Sbjct: 2317 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2376
Query: 2265 KLKKSKI---EDA--FSKEGK--SDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
++ +++ EDA F K+ + + L + L + ++ ++ + + +
Sbjct: 2377 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436
Query: 2318 AIENLHKSEEMLKERQS--DQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPY 2375
AI L + +E L++ +Q + + E + ++ LS + L +
Sbjct: 2437 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2496
Query: 2376 SEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEI 2435
E ++ +L++D+ + L + Q + + + R S + E
Sbjct: 2497 QEKAKLE--------QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2548
Query: 2436 SECLSEKSLSIHSNVHSDRLLE---------LKSPTELMKSKERSDVEHEQQVTESPSLA 2486
E + K + R E L+ +L++ + R+ + H ++VT S A
Sbjct: 2549 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2608
Query: 2487 S 2487
+
Sbjct: 2609 T 2609
Score = 73.6 bits (179), Expect = 3e-12
Identities = 180/910 (19%), Positives = 377/910 (41%), Gaps = 99/910 (10%)
Query: 1341 ESVRQLSDVERVRGISLAQQESV--SLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
E +Q + E R LA++ + +LA+ K Q+Q E D A + +AE+ E +
Sbjct: 1769 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1828
Query: 1399 EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAEL 1458
E + ++ +++R + + ++ + + + A+ D ++ ++ +
Sbjct: 1829 GEATRLKTEAEIALKEKEAENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK- 1886
Query: 1459 TRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTE---TDRKSPSVSLSQSKEGTL 1515
SD+ + L QR+ + + + L+ E + + L + +
Sbjct: 1887 ----ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1942
Query: 1516 DSKHQKYSASYDSYSESSGYKNHDRRSSSGSSR-QESPSVPSCKENEKKLNGEKIE---S 1571
D+ K A ++ + +RR R Q+S + ++K E++E +
Sbjct: 1943 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2002
Query: 1572 SIDEQVQTAADDSLRSDSVPSLPDEKDSTSI-ATEYSLKFDESMTEDEI-----EEQSFR 1625
++E + S L E + A E + F E E+ +EQS
Sbjct: 2003 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2062
Query: 1626 SLLPSESH-RRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMV 1684
L E+ R E+ ++ EA+ + + A+ L S + + ++ +
Sbjct: 2063 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ--SAEEQAQARAQAQAA 2120
Query: 1685 RQYM-KEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQK---KHLRDKGEDDKMPPLR 1740
+ + KE E AA ++ + + AL++K A+ +H+K + LR K +
Sbjct: 2121 AEKLRKEAEQEAARRA---QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ-------- 2169
Query: 1741 KKQRGLLLRLQQEKA---------EIKRLQ-EANKAARKERQLILKQQEEIEKIRQTTIK 1790
+Q LRLQ E+ E++RL+ EA +AAR+ Q+ +EE+ +R +
Sbjct: 2170 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV----EEELFSVRVQMEE 2225
Query: 1791 LQEKLKSAGESK---LDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLK 1847
L KLK+ E++ L D+T+ + +S+++ E + + Q +
Sbjct: 2226 L-SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2284
Query: 1848 K---MRSRMDEKFLTKREQKLMQ--RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDK 1902
+ + + EK L ++ Q + + R + ELL+ ++ L E+A Q +K+ +A
Sbjct: 2285 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2344
Query: 1903 ELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIG 1962
E + + ++ LE +R Q E+++E E + ++ + EE + +E IG
Sbjct: 2345 E--ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK--QAEEIG 2400
Query: 1963 QEQPGSPDHSILTEEMI-CSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLP 2021
++ + + T+E + Q LE S H + ++++ E K + + L
Sbjct: 2401 EKLHRT---ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-LQ 2456
Query: 2022 IKSHQHCYSWSDESLSMTQS---ETTSDQSDIEGRIRALKDELRKRKSV-------VNQL 2071
+KS + ++ L TQ+ S++ + R R ++ E K + + QL
Sbjct: 2457 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2516
Query: 2072 KKEQKKRQ------KERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTL 2125
++EQ+++Q ++RL A ++ +E +++ + EL Q LE + ++
Sbjct: 2517 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-QQLEQQRRQQEELLAE 2575
Query: 2126 SSASEKPKIKPLTPLHRSETAKNWKSLTESE--------RSRGSLESIAEHVDA--SLSG 2175
+ + +++ L HR+ A + + +T S+ R +L+ A + S G
Sbjct: 2576 ENQRLREQLQLLEEQHRAALAHS-EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDG 2634
Query: 2176 SERSVSERSL 2185
R VS + L
Sbjct: 2635 LRRKVSAQRL 2644
Score = 62.8 bits (151), Expect = 5e-09
Identities = 154/835 (18%), Positives = 304/835 (36%), Gaps = 132/835 (15%)
Query: 1136 EDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSSTSSKGK---------KGKKEKTEWLD 1186
E+ R+ A + + ++ + Q A+ K K + ++E L
Sbjct: 1964 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2023
Query: 1187 SFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTD-STLEDLSGHSVSVSS 1245
Q L EEKA + Q K+ ++ +QTL + S L+ L G + +
Sbjct: 2024 LAQEAAQKRLQAEEKAHAFAVQQKE---------QELQQTLQQEQSVLDQLRGEAEAARR 2074
Query: 1246 DKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASR 1305
+++ ++Q Q + A ER K S + A L A +
Sbjct: 2075 AAEEAEEARVQAEREAAQSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130
Query: 1306 TTTENMAPIPGSKRFSPAGLHHRMAAELS---YLNAIEESVRQLSDVER-VRGISLAQQE 1361
+ A L + AA+ + E+++RQ + VE+ + + L +E
Sbjct: 2131 EAARRA-------QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2183
Query: 1362 SVSLAQIIKAQQQR---HERDLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQ 1418
+ ++ + QR + A + + E+E + Q+EE A++ AE+ +++
Sbjct: 2184 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2243
Query: 1419 SQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELTRTHISDAVVASGAPLAILY 1478
+ LQE K+ E ARL+ AA++ + +L ++ A+
Sbjct: 2244 DKDNTQRFLQEEAEKMKQVAEEAARLSV-AAQEAARLRQLAEEDLAQ-------QRALAE 2295
Query: 1479 DHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNH 1538
++ + + R + E + L+Q + L + K + E+ G+
Sbjct: 2296 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL--QEDKEQMAQQLAEETQGF--- 2350
Query: 1539 DRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKD 1598
Q + ++ E E+++ + E + A
Sbjct: 2351 ----------QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR---------------- 2384
Query: 1599 STSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRF--NMEKRRGHHDDSDEEASPEK 1656
A E + +F + +EI E+ R+ L ++ +E +R D E
Sbjct: 2385 ----AEEDAQRFRKQ--AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2438
Query: 1657 TTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLR----LREKALKEK 1712
L KE K E +K EEM+ Q LL+ L++ L EK
Sbjct: 2439 AELEREKE-------------KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2485
Query: 1713 TK--AELAWLEHQKKHLRDKGEDD--KMPPLRKKQRGLLLRLQQEKAE-IKRLQEANKAA 1767
++E +K L +D+ K LR++Q+ +++QE+ + ++EA +
Sbjct: 2486 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2545
Query: 1768 RKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLD--------------SHSDDDTKD 1813
+ + + ++QEE++++ Q + QE+L + +L +HS++ T
Sbjct: 2546 HEAEEGVRRKQEELQQLEQQR-RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2604
Query: 1814 NKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKRE--QKLMQ---- 1867
A + + P + + E S + K R+ E + E Q+L Q
Sbjct: 2605 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTT 2664
Query: 1868 -----RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQ 1917
RR+ L+ + + + + AA ++L+ P T LE Q
Sbjct: 2665 VDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2719
Score = 58.2 bits (139), Expect = 1e-07
Identities = 132/715 (18%), Positives = 300/715 (41%), Gaps = 88/715 (12%)
Query: 1683 MVRQYMK--EEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLR 1740
+ QY+K E +R + L +++A + + AE+ +++ L + K R
Sbjct: 1315 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1374
Query: 1741 KKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTT-IKLQEKLKSAG 1799
+ + L R+Q+E + R +EA A+++++ I QEE++++RQ++ ++Q K + A
Sbjct: 1375 EAKE-LQQRMQEE---VVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQAE 1427
Query: 1800 ESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
++ ++ T+ + R + + + + + +K +++ + + L
Sbjct: 1428 AAERSRLRIEEEIRVVRLQLEATERQ-RGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1486
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRT 1919
++ Q QR++ AE L + + +AE A +Q QAL + + + ++ E +R
Sbjct: 1487 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1546
Query: 1920 EQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMI 1979
Q ++A E ++ S EL S + E+ + S+ E +
Sbjct: 1547 RQVQVALE-----------TAQRSAEAELQSKRASFA-------EKTAQLERSLQEEHVA 1588
Query: 1980 CSQ-ELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSM 2038
+Q E+ + + + +++E + + L +++ + +SL+
Sbjct: 1589 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA---QQKSLAQ 1645
Query: 2039 TQSETTSDQSDIEGRIRALKDE--LRKRKSVVNQLKKEQKKRQ---KERLKAQEASLIKQ 2093
++E ++++ E R R +E +R+R+ +L+K+++ + ++RL A++ + +
Sbjct: 1646 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1705
Query: 2094 LESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLT 2153
E+ + E + L A+ Q + ++ ++ +++ R+E
Sbjct: 1706 AET-------EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE--------- 1749
Query: 2154 ESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSR 2213
L S A + S S SE+ S++ L A A R E + + + R
Sbjct: 1750 ----MEVLLASKARAEEESRSTSEK--SKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1803
Query: 2214 KIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSK---KSEI----KEIEYTKL 2266
++ EE ++ R+L +GE+++ ++EI KE E +L
Sbjct: 1804 QLAEEDA-----------ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1852
Query: 2267 KKSKIEDAFSK--------EGKSDVLLKLV-LEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
++ ++AF + + K+D+ +L L + SE+ +K L D+ Q+ V
Sbjct: 1853 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-QRRQVEE 1911
Query: 2318 AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKE 2372
I L S E +++ ++ + +D K E + + L A +E
Sbjct: 1912 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1966
Score = 47.8 bits (112), Expect = 2e-04
Identities = 245/1386 (17%), Positives = 511/1386 (36%), Gaps = 225/1386 (16%)
Query: 1739 LRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLI-----LKQQEEIEKIRQTTIKLQE 1793
LR+ + L QQ E +RL E A K+RQL K Q E E ++ ++QE
Sbjct: 1327 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA-KELQQRMQE 1385
Query: 1794 KLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRM 1853
++ E+ +D+ + ++ L S + I + + + ++ R R+
Sbjct: 1386 EVVRREEAAVDAQ-----QQKRSIQEELQQLRQSSEAEIQAKARQAEAA----ERSRLRI 1436
Query: 1854 DEKFLTKREQKLMQRRQH--AEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPK 1911
+E+ R Q RQ AE L+ R AEEAE ++ + Q A + ++ ++ +
Sbjct: 1437 EEEIRVVRLQLEATERQRGGAEGELQ-ALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1495
Query: 1912 K-----ELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEE-LGSPAVEYVPSESIGQEQ 1965
K EL + + E A E++ + L ++ E L VE + E
Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE- 1554
Query: 1966 PGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSH 2025
T + EL+S + + S+ ++ + R ++
Sbjct: 1555 ---------TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE--------EAE 1597
Query: 2026 QHCYSWSDESLSMTQSETTSDQSDIEG----RIRALKDELRKRKSVVN---QLKKEQKKR 2078
+ ++ + ++E ++ ++ R+R +E+ ++KS+ + +KE+ +R
Sbjct: 1598 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1657
Query: 2079 QKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLT 2138
+ R E ++Q E ++ ++K + A+ ++ L + +E+ + +
Sbjct: 1658 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ--R 1715
Query: 2139 PLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSR 2198
L E A+ + + + R LE+ V A + E L++ A+ E S
Sbjct: 1716 QLLEEELARLQREAAAATQKRQELEAELAKVRAEM--------EVLLASKARAEEESRST 1767
Query: 2199 TEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEI 2258
+E +S +++ E+G E L E A R L E+ ++ ++
Sbjct: 1768 SE---------KSKQRLEAEAGRFRE-------LAEEAARLRAL------AEEAKRQRQL 1805
Query: 2259 KEIEYTKLKKSKIEDAFSKEGKSD-VLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
E EDA + +++ VL + + G+++ + ++ ++ L + + +
Sbjct: 1806 AE-----------EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE---- 1850
Query: 2318 AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSE 2377
+ L + E + R +Q H DI E+
Sbjct: 1851 RLRRLAEDEAFQRRRLEEQAAQHKA------DIEER------------------------ 1880
Query: 2378 DFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNE---E 2434
++ +K +EL + V L R+ + ++ +++S A + G E E
Sbjct: 1881 ---LAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKASFEKAAA-GKAELELE 1933
Query: 2435 ISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESPSLASVPTADEL 2494
+ S ++ S ++ LE +L +ER E E++V +S +
Sbjct: 1934 LGRIRSNAEDTLRSKEQAE--LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1991
Query: 2495 FDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKH 2554
+R+ + LR + E A+ E + + +EK
Sbjct: 1992 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR------------LQAEEKA 2039
Query: 2555 GIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYE 2614
FA QK E Q QEQ+ + + E + + E
Sbjct: 2040 HAFAVQQK---------------------EQELQQTLQQEQSVLDQLRG-EAEAARRAAE 2077
Query: 2615 KSLPSVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKE-NKDLISDA 2673
++ + E +SR E + ++ A Q+ +Q ++++ K+ +A
Sbjct: 2078 EAEEARVQAEREAAQSRRQVEEAERLKQ-----SAEEQAQARAQAQAAAEKLRKEAEQEA 2132
Query: 2674 TEKVSIAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLL---------DLLT 2724
+ E+EK ++F E+ A+ ++L T L +LL
Sbjct: 2133 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2192
Query: 2725 REKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLS 2784
E +L+A+ + + + +++L + + + L K+ + I + +D +
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2252
Query: 2785 NQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDE--------KEEISSPDMCPR 2836
+E + K+V + +V Q + +L + KE++ + R
Sbjct: 2253 QEE--AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310
Query: 2837 PESPVFGASGQEELAKRLA-ELELSREFLSALGDDQDWFDEDFGLSSSHKIQKNKAEETI 2895
++ Q+ELA+ A L+ +E ++ Q +E G + + ++ + E
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMA-----QQLAEETQGFQRTLEAERQRQLE-- 2363
Query: 2896 VPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKELGHDLHSISIPTKLLG 2955
+ AE +R+ + E A E+ + A +E+G LH + T+
Sbjct: 2364 --MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLHRTELATQEKV 2414
Query: 2956 CASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMKPCRINSSYFRRVKNP 3015
+ L+I+ R + +E E+ E L Q K ++ S + V+
Sbjct: 2415 TLVQTLEIQ----RQQSDHDAERLREAIAELEREKEKLQQEA--KLLQLKSEEMQTVQQE 2468
Query: 3016 NNLDEIKSFIASEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVDHILVQELHEEEAQWV 3075
L E ++ S + + SL + + Q+ K + +D V Q+L EE+ +
Sbjct: 2469 QLLQETQALQQSFLSEKDSLLQ--RERFIEQEKAKLEQLFQDEV--AKAQQLREEQQRQQ 2524
Query: 3076 NYDEDE 3081
E E
Sbjct: 2525 QQMEQE 2530
Score = 47.4 bits (111), Expect = 2e-04
Identities = 109/504 (21%), Positives = 195/504 (38%), Gaps = 71/504 (14%)
Query: 1749 RLQQEKAEIKRLQEANKAA---RKERQLILKQQEEIEKI------RQTTIKLQEKLKSAG 1799
RL E ++ L E + AA R E +L L + E++ + + TI L +
Sbjct: 1028 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1087
Query: 1800 ESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
E L +H ++ K+ +A +LE T + ++KL+ F
Sbjct: 1088 EEVLRAH-EEQLKEAQAVPATLPELEA------------TKASLKKLRAQAEAQQPTFDA 1134
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRT 1919
R++ L ++ E L + D E R+ Q L W L + ++ELE
Sbjct: 1135 LRDE-LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQL-- 1191
Query: 1920 EQKEIASEEESPVPLYSHLNSESSIPEELGSP--AVEYVPSESIGQEQPGSPD---HSIL 1974
+++ ES PL + L E++ + A E + QEQ + H
Sbjct: 1192 -GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1250
Query: 1975 TEE--------MICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
EE + ++ E K L + K + GS Q ++ +++H
Sbjct: 1251 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTH- 1308
Query: 2027 HCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQ 2086
SE T+ S I+ + + LR R +L ++Q+ ++ERL
Sbjct: 1309 -------------YSELTTLTSQY---IKFISETLR-RMEEEERLAEQQRAEERERLAEV 1351
Query: 2087 EASLIKQLESYDEFIK-KTEA-----ELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPL 2140
EA+L KQ + + + K +A EL Q ++ + + + ++ + L L
Sbjct: 1352 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1411
Query: 2141 HRSETAK---NWKSLTESERSRGSLESIAEHVDASLSGSE--RSVSERSLSAYAKRVNEW 2195
+S A+ + +ERSR +E V L +E R +E L A R E
Sbjct: 1412 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1471
Query: 2196 DSRTEDFQTPSPVLRSSRKIREES 2219
+++ Q + LR R++++ES
Sbjct: 1472 EAQKRQAQEEAERLR--RQVQDES 1493
Score = 39.7 bits (91), Expect = 0.047
Identities = 64/315 (20%), Positives = 125/315 (39%), Gaps = 31/315 (9%)
Query: 358 EAEFQNMSRELYRDLALHFADDISIKEKPAEKSKEKKV-------VKPVRKVQKVAQLSS 410
EAE +EL ++ A +D KE+ A++ E+ + R+++ A+
Sbjct: 2314 EAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370
Query: 411 TECRTGSSHLISTSSWRDGQKLVKKILGPAPRMEPKEQRTASSDRGGRERTAKSGGHIGR 470
+ R + D Q+ K+ A + K RT + + + T I R
Sbjct: 2371 LKLRVAEMSRAQARAEEDAQRFRKQ----AEEIGEKLHRTELATQ--EKVTLVQTLEIQR 2424
Query: 471 AESDPRLDVLHRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRG 530
+SD + L R ER + K + E + +L S Q+E L
Sbjct: 2425 QQSDHDAERL-REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2483
Query: 531 ILDDLQLDSTAHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVIS---- 586
D L +Q+ +L+ A + +R+ ++ V S
Sbjct: 2484 EKDSLL--QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2541
Query: 587 KRRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQE----LYRKQKEAFTK 642
+RR ++ +E VR+++E ++ ++++ Q+E ++N+RL+E L + + A
Sbjct: 2542 RRRQHEAEEG----VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2597
Query: 643 VKNVPPSEPSATRRL 657
+ V S+ +AT+ L
Sbjct: 2598 SEEVTASQVAATKTL 2612
Score = 38.5 bits (88), Expect = 0.10
Identities = 72/383 (18%), Positives = 148/383 (38%), Gaps = 45/383 (11%)
Query: 383 KEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHLISTSSWRDGQ----KLVKKILG 438
+E E ++ + + + ++ +++A+ + R + +++ G+ K +I
Sbjct: 1783 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1842
Query: 439 PAPRMEPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERS------- 491
E + R + D + R + +A+ + RL L + ER
Sbjct: 1843 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1902
Query: 492 -RSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVE 550
R + + E I L +S E A K L +E+ I + + T + +Q +E
Sbjct: 1903 LRQRRQVEEEILALKASF------EKAAAGKAELELELGRIRSNAE--DTLRSKEQAELE 1954
Query: 551 LQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRK 610
Q+ A R +R + A E+ +++R +EV + + +E R+ +
Sbjct: 1955 AARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRKAALEEVERLKAKVEEARRLR 2011
Query: 611 QNEEKKAQKE---ATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKL--- 664
+ E+++ ++ A E KRLQ ++ AF V E + LQ+ S L
Sbjct: 2012 ERAEQESARQLQLAQEAAQKRLQA--EEKAHAFA----VQQKEQELQQTLQQEQSVLDQL 2065
Query: 665 ----LLEKTLLEEPSHQHVTQETQAKPGYQPSGESDK-----ENKVQERPPSASSSSDMS 715
+ EE V E +A + E+++ E + Q R A ++++
Sbjct: 2066 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-AQAQAAAEKL 2124
Query: 716 LSEPPQPLARKDLMESTWMQPER 738
E Q AR+ E ++ ++
Sbjct: 2125 RKEAEQEAARRAQAEQAALRQKQ 2147
Score = 33.1 bits (74), Expect = 4.4
Identities = 61/334 (18%), Positives = 124/334 (37%), Gaps = 44/334 (13%)
Query: 389 KSKEKKVVKPVRKVQKVAQLSST-----ECRTGSSHLISTSSWRDGQKLVKKILGPAPRM 443
K++ + V P +K + + S + RT S L + +S + +K I RM
Sbjct: 1276 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-----QYIKFISETLRRM 1330
Query: 444 EPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERSRSK--SRSENNI 501
E +E+ RER A+ + E +L H + +ER + R + +
Sbjct: 1331 EEEERLAEQQRAEERERLAEVEAAL---EKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1387
Query: 502 KKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVELQNQKSSAPVH 561
+ + D +Q++ + + E++ + + + A + + E + +
Sbjct: 1388 VRREEAAVDAQQQKRS------IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1441
Query: 562 A--------PRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNE 613
R + + + A + KR+ + E + V+ + +RKR+
Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1501
Query: 614 EK----KAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKT 669
E KA+ EA +K + LQ L + +A A RRL++ + +
Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRLQA-----------EEAERRLRQAEVERARQVQ 1550
Query: 670 LLEEPSHQHVTQETQAKPGYQPSGESDKENKVQE 703
+ E + + E Q+K + E +QE
Sbjct: 1551 VALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1584
Score = 32.7 bits (73), Expect = 5.8
Identities = 52/267 (19%), Positives = 107/267 (40%), Gaps = 35/267 (13%)
Query: 2619 SVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKENKDLI-SDATEKV 2677
S +D E L+ E + +Q + +L+ + +V + +E + L S +EK
Sbjct: 2427 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2486
Query: 2678 S-------IAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQL 2730
S I E L+ F +E+ K QQ EE+ + + +E+ +L
Sbjct: 2487 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ------------MEQERQRL 2534
Query: 2731 EAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLG 2790
A ++ + + ++++ + + ++ + QL+Q ++ ++E + NQ L
Sbjct: 2535 VASMEEARRRQHEAEEGVRR------------KQEELQQLEQQRRQQEELLAEENQR-LR 2581
Query: 2791 DDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDEKEEISSPDMCPRPESPVFGASGQEEL 2850
+ + + Q + + + S + L + ++ + P PE F ++
Sbjct: 2582 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS-FDGLRRKVS 2640
Query: 2851 AKRLAELE-LSREFLSALGDDQDWFDE 2876
A+RL E LS E L L DE
Sbjct: 2641 AQRLQEAGILSAEELQRLAQGHTTVDE 2667
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 91.7 bits (226), Expect = 1e-17
Identities = 219/1114 (19%), Positives = 446/1114 (40%), Gaps = 162/1114 (14%)
Query: 1335 YLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALES 1394
Y+ I E++R++ + ER+ A+QQR E L +++A ALE
Sbjct: 1360 YIKFISETLRRMEEEERL------------------AEQQRAEERERLAEVEA---ALEK 1398
Query: 1395 QRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCK-----IAAQQSETA------- 1442
QRQL A+ HA++ Q + +E+ + +QE + + AQQ + +
Sbjct: 1399 QRQL-------AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1451
Query: 1443 -RLTTDA-----ARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTR- 1495
R +++A ARQ E AE +R I + + L + QR ++ LR R
Sbjct: 1452 LRQSSEAEIQAKARQ-AEAAERSRLRIEEEIRVVRLQLEAT-ERQRGGAEGELQALRARA 1509
Query: 1496 --TETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPS 1553
E ++ + + D +K A + S R E
Sbjct: 1510 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1569
Query: 1554 VPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDES 1613
+ +E E++L ++E + QVQ A + + RS + + + E + + + S
Sbjct: 1570 L-QAEEAERRLRQAEVERA--RQVQVALETAQRSAEA----ELQSKRASFAEKTAQLERS 1622
Query: 1614 MTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQ 1673
+ E+ + R + ++ E+ R + E E+ L + L + +
Sbjct: 1623 LQEEHVAVAQLREEAERRAQQQAEAERAR-----EEAERELERWQLKANEALRLRLQAEE 1677
Query: 1674 DSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGED 1733
+ K + + KEE R A + + E+A++++ ELA E +K+ R E
Sbjct: 1678 VAQQKSLAQAEAEKQKEEAEREARRRG--KAEEQAVRQR---ELAEQELEKQ--RQLAEG 1730
Query: 1734 DKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQE 1793
L +Q + LR + E+ E +R + AR +R+ Q+ +++ K++
Sbjct: 1731 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR-QELEAELAKVRA 1789
Query: 1794 KLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRM 1853
+++ SK + ++++++ S + E ++ ++ ++ ++ K+ R
Sbjct: 1790 EMEVLLASK--ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-- 1845
Query: 1854 DEKFLTKREQKLMQRRQHAEELLEWKRRLDAE------EAEIRQMEKQALAAWDKELIKP 1907
E+ ++R AE +L K E EAEI EK+A + L +
Sbjct: 1846 ------LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1899
Query: 1908 KT-PKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQP 1966
+ ++ LE+Q + K A EE L +SE + Q
Sbjct: 1900 EAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSEL--------------------ERQK 1937
Query: 1967 GSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
G ++ + + +++E K S K+ ++ E G R+ + L K
Sbjct: 1938 G-----LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1992
Query: 2027 HCYSWSDESLSMTQSETTSDQSD-IEGRIRALKDELRKRKSVVNQL-----KKEQKKRQK 2080
+ L+ + + + ++ + A ++ R+RK+ + ++ K E+ +R +
Sbjct: 1993 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2052
Query: 2081 ERLK---------AQEASLIKQLESYDE----FIKKTEAELSQDLETSPTAKPQIKTLSS 2127
ER + AQEA+ K+L++ ++ +++ E EL Q L+ + Q++ +
Sbjct: 2053 ERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2111
Query: 2128 ASEK--PKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSL 2185
A+ + + + E A++ + + E+ER + S E A+ + + +E+ E
Sbjct: 2112 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171
Query: 2186 SAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREES----GDSLENVPALHL-LKELNATSR 2240
A A+R + Q + +K E++ + + L L L+E +
Sbjct: 2172 EA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2230
Query: 2241 ILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVL--LKLVLEQGDSSEIL 2298
+LD E ++ + + E + + E+ FS + + L LK +E + + IL
Sbjct: 2231 LLD-------EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2283
Query: 2299 SKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKE 2358
KD N Q+ L A + +EE + + Q+ + + +D+ +Q+ E
Sbjct: 2284 RDKD------NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAE 2336
Query: 2359 KDLSWSEHLFAPKEIP-YSEDFEVSSFKKEISAE 2391
K L E + A +E + E+ +KE++ E
Sbjct: 2337 KML--KEKMQAVQEATRLKAEAELLQQQKELAQE 2368
Score = 73.6 bits (179), Expect = 3e-12
Identities = 227/1261 (18%), Positives = 480/1261 (38%), Gaps = 182/1261 (14%)
Query: 1339 IEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
I+ RQ ER R + + ++ V Q+ ++QR + L L+A E E+Q+
Sbjct: 1460 IQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK-- 1516
Query: 1399 EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAEL 1458
+ AQ AE L++ VQ + ++ ++A ++A++ A + R + + EL
Sbjct: 1517 -----RQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1568
Query: 1459 TRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSK 1518
R +A RQ + +Q++ ET ++S L QSK + K
Sbjct: 1569 -RLQAEEAE-----------RRLRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAEK 1615
Query: 1519 HQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQ 1578
+ S + R + ++Q++ + + +E E++L +++++ +++
Sbjct: 1616 TAQLERSLQEEHVAVAQL---REEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1672
Query: 1579 TAADDSLRSDSVPSLPDEKDSTSI---------ATEYSLKFDESMTEDEIEEQSFRSLLP 1629
A++ + S+ EK A E +++ E + E E+E+Q R L
Sbjct: 1673 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE-LAEQELEKQ--RQLAE 1729
Query: 1630 SESHRRFNMEKRRGHHDDSDEEASPEKTTLSTA-KELNMPFSGGQDSFSKFTMEM--VRQ 1686
+ +R E+ E+ ++ L L + + E+ VR
Sbjct: 1730 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1789
Query: 1687 YMK---------EEEMRAAHQSSLLRLREKALKEKTKAE----LAWLEHQKKHLRDKGED 1733
M+ EEE R+ + S RL +A + + AE L L + K R E+
Sbjct: 1790 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1849
Query: 1734 DKMPPLRKKQRGLLLRLQQ--EKAEIKRLQEA---NKAARKERQLILKQQEEIEKIRQTT 1788
D + +R L +L E +K E K A ER L + E ++ R
Sbjct: 1850 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1909
Query: 1789 IKLQEK---------LKSAGESKLDSHS---DDDTKDNKATSPGPTDLETRSPSPISISS 1836
Q K L+ A +S+L+ +D + + L+ + ++
Sbjct: 1910 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK----ASFEKAA 1965
Query: 1837 SETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEE-------AEI 1889
+ + + +L ++RS ++ +K + +L RQ E +RR +AEE AE
Sbjct: 1966 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2025
Query: 1890 RQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELG 1949
++ A + E +K K + +R EQ+ + + L +E
Sbjct: 2026 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK------ 2079
Query: 1950 SPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSK 2009
+ + +Q L +E +L ++ + ++ +E+
Sbjct: 2080 --------AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA------EEARV 2125
Query: 2010 GSHRTGGQCHLPIKSHQHC-YSWSDESLSMTQSETTSD------QSDIEGRIRALKDELR 2062
+ R Q ++ + S +++ + Q++ ++ + + R +A + LR
Sbjct: 2126 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2185
Query: 2063 KRKSVVNQLKK-----EQKKRQKERLKAQEASLIKQLES-------YDEFIKKTEAEL-- 2108
++++ +++K EQ RQK +++ + +L QLE DE +++ +AE
Sbjct: 2186 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2245
Query: 2109 -----SQDLETSPTAKPQIKTLSSASEKPKI---------KPLTPLHRSETAKNWKSLTE 2154
SQ E + + Q++ LS + + K T E A+ K + E
Sbjct: 2246 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2305
Query: 2155 -------SERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSP 2207
+ + L +AE A +R+++E+ L + V E + +
Sbjct: 2306 EAARLSVAAQEAARLRQLAEEDLA----QQRALAEKMLKEKMQAVQE----ATRLKAEAE 2357
Query: 2208 VLRSSRKIREESGDSLE---NVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYT 2264
+L+ +++ +E L+ A L +E R L+ + E S ++E ++
Sbjct: 2358 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417
Query: 2265 KLKKSKI---EDA--FSKEGK--SDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
++ +++ EDA F K+ + + L + L + ++ ++ + + +
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477
Query: 2318 AIENLHKSEEMLKERQS--DQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPY 2375
AI L + +E L++ +Q + + E + ++ LS + L +
Sbjct: 2478 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2537
Query: 2376 SEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEI 2435
E ++ +L++D+ + L + Q + + + R S + E
Sbjct: 2538 QEKAKLE--------QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2589
Query: 2436 SECLSEKSLSIHSNVHSDRLLE---------LKSPTELMKSKERSDVEHEQQVTESPSLA 2486
E + K + R E L+ +L++ + R+ + H ++VT S A
Sbjct: 2590 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2649
Query: 2487 S 2487
+
Sbjct: 2650 T 2650
Score = 73.6 bits (179), Expect = 3e-12
Identities = 180/910 (19%), Positives = 377/910 (41%), Gaps = 99/910 (10%)
Query: 1341 ESVRQLSDVERVRGISLAQQESV--SLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL 1398
E +Q + E R LA++ + +LA+ K Q+Q E D A + +AE+ E +
Sbjct: 1810 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1869
Query: 1399 EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAEL 1458
E + ++ +++R + + ++ + + + A+ D ++ ++ +
Sbjct: 1870 GEATRLKTEAEIALKEKEAENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK- 1927
Query: 1459 TRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTE---TDRKSPSVSLSQSKEGTL 1515
SD+ + L QR+ + + + L+ E + + L + +
Sbjct: 1928 ----ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1983
Query: 1516 DSKHQKYSASYDSYSESSGYKNHDRRSSSGSSR-QESPSVPSCKENEKKLNGEKIE---S 1571
D+ K A ++ + +RR R Q+S + ++K E++E +
Sbjct: 1984 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2043
Query: 1572 SIDEQVQTAADDSLRSDSVPSLPDEKDSTSI-ATEYSLKFDESMTEDEI-----EEQSFR 1625
++E + S L E + A E + F E E+ +EQS
Sbjct: 2044 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2103
Query: 1626 SLLPSESH-RRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMV 1684
L E+ R E+ ++ EA+ + + A+ L S + + ++ +
Sbjct: 2104 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ--SAEEQAQARAQAQAA 2161
Query: 1685 RQYM-KEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQK---KHLRDKGEDDKMPPLR 1740
+ + KE E AA ++ + + AL++K A+ +H+K + LR K +
Sbjct: 2162 AEKLRKEAEQEAARRA---QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ-------- 2210
Query: 1741 KKQRGLLLRLQQEKA---------EIKRLQ-EANKAARKERQLILKQQEEIEKIRQTTIK 1790
+Q LRLQ E+ E++RL+ EA +AAR+ Q+ +EE+ +R +
Sbjct: 2211 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV----EEELFSVRVQMEE 2266
Query: 1791 LQEKLKSAGESK---LDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLK 1847
L KLK+ E++ L D+T+ + +S+++ E + + Q +
Sbjct: 2267 L-SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2325
Query: 1848 K---MRSRMDEKFLTKREQKLMQ--RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDK 1902
+ + + EK L ++ Q + + R + ELL+ ++ L E+A Q +K+ +A
Sbjct: 2326 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2385
Query: 1903 ELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIG 1962
E + + ++ LE +R Q E+++E E + ++ + EE + +E IG
Sbjct: 2386 E--ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK--QAEEIG 2441
Query: 1963 QEQPGSPDHSILTEEMI-CSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLP 2021
++ + + T+E + Q LE S H + ++++ E K + + L
Sbjct: 2442 EKLHRT---ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-LQ 2497
Query: 2022 IKSHQHCYSWSDESLSMTQS---ETTSDQSDIEGRIRALKDELRKRKSV-------VNQL 2071
+KS + ++ L TQ+ S++ + R R ++ E K + + QL
Sbjct: 2498 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2557
Query: 2072 KKEQKKRQ------KERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTL 2125
++EQ+++Q ++RL A ++ +E +++ + EL Q LE + ++
Sbjct: 2558 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-QQLEQQRRQQEELLAE 2616
Query: 2126 SSASEKPKIKPLTPLHRSETAKNWKSLTESE--------RSRGSLESIAEHVDA--SLSG 2175
+ + +++ L HR+ A + + +T S+ R +L+ A + S G
Sbjct: 2617 ENQRLREQLQLLEEQHRAALAHS-EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDG 2675
Query: 2176 SERSVSERSL 2185
R VS + L
Sbjct: 2676 LRRKVSAQRL 2685
Score = 62.8 bits (151), Expect = 5e-09
Identities = 154/835 (18%), Positives = 304/835 (36%), Gaps = 132/835 (15%)
Query: 1136 EDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSSTSSKGK---------KGKKEKTEWLD 1186
E+ R+ A + + ++ + Q A+ K K + ++E L
Sbjct: 2005 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2064
Query: 1187 SFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTD-STLEDLSGHSVSVSS 1245
Q L EEKA + Q K+ ++ +QTL + S L+ L G + +
Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKE---------QELQQTLQQEQSVLDQLRGEAEAARR 2115
Query: 1246 DKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASR 1305
+++ ++Q Q + A ER K S + A L A +
Sbjct: 2116 AAEEAEEARVQAEREAAQSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171
Query: 1306 TTTENMAPIPGSKRFSPAGLHHRMAAELS---YLNAIEESVRQLSDVER-VRGISLAQQE 1361
+ A L + AA+ + E+++RQ + VE+ + + L +E
Sbjct: 2172 EAARRA-------QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2224
Query: 1362 SVSLAQIIKAQQQR---HERDLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQ 1418
+ ++ + QR + A + + E+E + Q+EE A++ AE+ +++
Sbjct: 2225 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2284
Query: 1419 SQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELTRTHISDAVVASGAPLAILY 1478
+ LQE K+ E ARL+ AA++ + +L ++ A+
Sbjct: 2285 DKDNTQRFLQEEAEKMKQVAEEAARLSV-AAQEAARLRQLAEEDLAQ-------QRALAE 2336
Query: 1479 DHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNH 1538
++ + + R + E + L+Q + L + K + E+ G+
Sbjct: 2337 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL--QEDKEQMAQQLAEETQGF--- 2391
Query: 1539 DRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKD 1598
Q + ++ E E+++ + E + A
Sbjct: 2392 ----------QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR---------------- 2425
Query: 1599 STSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRF--NMEKRRGHHDDSDEEASPEK 1656
A E + +F + +EI E+ R+ L ++ +E +R D E
Sbjct: 2426 ----AEEDAQRFRKQ--AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2479
Query: 1657 TTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLR----LREKALKEK 1712
L KE K E +K EEM+ Q LL+ L++ L EK
Sbjct: 2480 AELEREKE-------------KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2526
Query: 1713 TK--AELAWLEHQKKHLRDKGEDD--KMPPLRKKQRGLLLRLQQEKAE-IKRLQEANKAA 1767
++E +K L +D+ K LR++Q+ +++QE+ + ++EA +
Sbjct: 2527 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2586
Query: 1768 RKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLD--------------SHSDDDTKD 1813
+ + + ++QEE++++ Q + QE+L + +L +HS++ T
Sbjct: 2587 HEAEEGVRRKQEELQQLEQQR-RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2645
Query: 1814 NKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKRE--QKLMQ---- 1867
A + + P + + E S + K R+ E + E Q+L Q
Sbjct: 2646 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTT 2705
Query: 1868 -----RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQ 1917
RR+ L+ + + + + AA ++L+ P T LE Q
Sbjct: 2706 VDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2760
Score = 58.2 bits (139), Expect = 1e-07
Identities = 132/715 (18%), Positives = 300/715 (41%), Gaps = 88/715 (12%)
Query: 1683 MVRQYMK--EEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLR 1740
+ QY+K E +R + L +++A + + AE+ +++ L + K R
Sbjct: 1356 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1415
Query: 1741 KKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTT-IKLQEKLKSAG 1799
+ + L R+Q+E + R +EA A+++++ I QEE++++RQ++ ++Q K + A
Sbjct: 1416 EAKE-LQQRMQEE---VVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQAE 1468
Query: 1800 ESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
++ ++ T+ + R + + + + + +K +++ + + L
Sbjct: 1469 AAERSRLRIEEEIRVVRLQLEATERQ-RGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1527
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRT 1919
++ Q QR++ AE L + + +AE A +Q QAL + + + ++ E +R
Sbjct: 1528 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1587
Query: 1920 EQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMI 1979
Q ++A E ++ S EL S + E+ + S+ E +
Sbjct: 1588 RQVQVALE-----------TAQRSAEAELQSKRASFA-------EKTAQLERSLQEEHVA 1629
Query: 1980 CSQ-ELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSM 2038
+Q E+ + + + +++E + + L +++ + +SL+
Sbjct: 1630 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA---QQKSLAQ 1686
Query: 2039 TQSETTSDQSDIEGRIRALKDE--LRKRKSVVNQLKKEQKKRQ---KERLKAQEASLIKQ 2093
++E ++++ E R R +E +R+R+ +L+K+++ + ++RL A++ + +
Sbjct: 1687 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1746
Query: 2094 LESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLT 2153
E+ + E + L A+ Q + ++ ++ +++ R+E
Sbjct: 1747 AET-------EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE--------- 1790
Query: 2154 ESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSR 2213
L S A + S S SE+ S++ L A A R E + + + R
Sbjct: 1791 ----MEVLLASKARAEEESRSTSEK--SKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1844
Query: 2214 KIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSK---KSEI----KEIEYTKL 2266
++ EE ++ R+L +GE+++ ++EI KE E +L
Sbjct: 1845 QLAEEDA-----------ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1893
Query: 2267 KKSKIEDAFSK--------EGKSDVLLKLV-LEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
++ ++AF + + K+D+ +L L + SE+ +K L D+ Q+ V
Sbjct: 1894 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-QRRQVEE 1952
Query: 2318 AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKE 2372
I L S E +++ ++ + +D K E + + L A +E
Sbjct: 1953 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2007
Score = 47.8 bits (112), Expect = 2e-04
Identities = 245/1386 (17%), Positives = 511/1386 (36%), Gaps = 225/1386 (16%)
Query: 1739 LRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLI-----LKQQEEIEKIRQTTIKLQE 1793
LR+ + L QQ E +RL E A K+RQL K Q E E ++ ++QE
Sbjct: 1368 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA-KELQQRMQE 1426
Query: 1794 KLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRM 1853
++ E+ +D+ + ++ L S + I + + + ++ R R+
Sbjct: 1427 EVVRREEAAVDAQ-----QQKRSIQEELQQLRQSSEAEIQAKARQAEAA----ERSRLRI 1477
Query: 1854 DEKFLTKREQKLMQRRQH--AEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPK 1911
+E+ R Q RQ AE L+ R AEEAE ++ + Q A + ++ ++ +
Sbjct: 1478 EEEIRVVRLQLEATERQRGGAEGELQ-ALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536
Query: 1912 K-----ELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEE-LGSPAVEYVPSESIGQEQ 1965
K EL + + E A E++ + L ++ E L VE + E
Sbjct: 1537 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE- 1595
Query: 1966 PGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSH 2025
T + EL+S + + S+ ++ + R ++
Sbjct: 1596 ---------TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE--------EAE 1638
Query: 2026 QHCYSWSDESLSMTQSETTSDQSDIEG----RIRALKDELRKRKSVVN---QLKKEQKKR 2078
+ ++ + ++E ++ ++ R+R +E+ ++KS+ + +KE+ +R
Sbjct: 1639 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1698
Query: 2079 QKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLT 2138
+ R E ++Q E ++ ++K + A+ ++ L + +E+ + +
Sbjct: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ--R 1756
Query: 2139 PLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSR 2198
L E A+ + + + R LE+ V A + E L++ A+ E S
Sbjct: 1757 QLLEEELARLQREAAAATQKRQELEAELAKVRAEM--------EVLLASKARAEEESRST 1808
Query: 2199 TEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEI 2258
+E +S +++ E+G E L E A R L E+ ++ ++
Sbjct: 1809 SE---------KSKQRLEAEAGRFRE-------LAEEAARLRAL------AEEAKRQRQL 1846
Query: 2259 KEIEYTKLKKSKIEDAFSKEGKSD-VLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGL 2317
E EDA + +++ VL + + G+++ + ++ ++ L + + +
Sbjct: 1847 AE-----------EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE---- 1891
Query: 2318 AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSE 2377
+ L + E + R +Q H DI E+
Sbjct: 1892 RLRRLAEDEAFQRRRLEEQAAQHKA------DIEER------------------------ 1921
Query: 2378 DFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNE---E 2434
++ +K +EL + V L R+ + ++ +++S A + G E E
Sbjct: 1922 ---LAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKASFEKAAA-GKAELELE 1974
Query: 2435 ISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESPSLASVPTADEL 2494
+ S ++ S ++ LE +L +ER E E++V +S +
Sbjct: 1975 LGRIRSNAEDTLRSKEQAE--LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2032
Query: 2495 FDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKH 2554
+R+ + LR + E A+ E + + +EK
Sbjct: 2033 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR------------LQAEEKA 2080
Query: 2555 GIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYE 2614
FA QK E Q QEQ+ + + E + + E
Sbjct: 2081 HAFAVQQK---------------------EQELQQTLQQEQSVLDQLRG-EAEAARRAAE 2118
Query: 2615 KSLPSVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKE-NKDLISDA 2673
++ + E +SR E + ++ A Q+ +Q ++++ K+ +A
Sbjct: 2119 EAEEARVQAEREAAQSRRQVEEAERLKQ-----SAEEQAQARAQAQAAAEKLRKEAEQEA 2173
Query: 2674 TEKVSIAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLL---------DLLT 2724
+ E+EK ++F E+ A+ ++L T L +LL
Sbjct: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
Query: 2725 REKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLS 2784
E +L+A+ + + + +++L + + + L K+ + I + +D +
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2293
Query: 2785 NQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDE--------KEEISSPDMCPR 2836
+E + K+V + +V Q + +L + KE++ + R
Sbjct: 2294 QEE--AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351
Query: 2837 PESPVFGASGQEELAKRLA-ELELSREFLSALGDDQDWFDEDFGLSSSHKIQKNKAEETI 2895
++ Q+ELA+ A L+ +E ++ Q +E G + + ++ + E
Sbjct: 2352 LKAEAELLQQQKELAQEQARRLQEDKEQMA-----QQLAEETQGFQRTLEAERQRQLE-- 2404
Query: 2896 VPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKELGHDLHSISIPTKLLG 2955
+ AE +R+ + E A E+ + A +E+G LH + T+
Sbjct: 2405 --MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLHRTELATQEKV 2455
Query: 2956 CASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMKPCRINSSYFRRVKNP 3015
+ L+I+ R + +E E+ E L Q K ++ S + V+
Sbjct: 2456 TLVQTLEIQ----RQQSDHDAERLREAIAELEREKEKLQQEA--KLLQLKSEEMQTVQQE 2509
Query: 3016 NNLDEIKSFIASEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVDHILVQELHEEEAQWV 3075
L E ++ S + + SL + + Q+ K + +D V Q+L EE+ +
Sbjct: 2510 QLLQETQALQQSFLSEKDSLLQ--RERFIEQEKAKLEQLFQDEV--AKAQQLREEQQRQQ 2565
Query: 3076 NYDEDE 3081
E E
Sbjct: 2566 QQMEQE 2571
Score = 47.4 bits (111), Expect = 2e-04
Identities = 109/504 (21%), Positives = 195/504 (38%), Gaps = 71/504 (14%)
Query: 1749 RLQQEKAEIKRLQEANKAA---RKERQLILKQQEEIEKI------RQTTIKLQEKLKSAG 1799
RL E ++ L E + AA R E +L L + E++ + + TI L +
Sbjct: 1069 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1128
Query: 1800 ESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLT 1859
E L +H ++ K+ +A +LE T + ++KL+ F
Sbjct: 1129 EEVLRAH-EEQLKEAQAVPATLPELEA------------TKASLKKLRAQAEAQQPTFDA 1175
Query: 1860 KREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRT 1919
R++ L ++ E L + D E R+ Q L W L + ++ELE
Sbjct: 1176 LRDE-LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQL-- 1232
Query: 1920 EQKEIASEEESPVPLYSHLNSESSIPEELGSP--AVEYVPSESIGQEQPGSPD---HSIL 1974
+++ ES PL + L E++ + A E + QEQ + H
Sbjct: 1233 -GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1291
Query: 1975 TEE--------MICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
EE + ++ E K L + K + GS Q ++ +++H
Sbjct: 1292 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTH- 1349
Query: 2027 HCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQ 2086
SE T+ S I+ + + LR R +L ++Q+ ++ERL
Sbjct: 1350 -------------YSELTTLTSQY---IKFISETLR-RMEEEERLAEQQRAEERERLAEV 1392
Query: 2087 EASLIKQLESYDEFIK-KTEA-----ELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPL 2140
EA+L KQ + + + K +A EL Q ++ + + + ++ + L L
Sbjct: 1393 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452
Query: 2141 HRSETAK---NWKSLTESERSRGSLESIAEHVDASLSGSE--RSVSERSLSAYAKRVNEW 2195
+S A+ + +ERSR +E V L +E R +E L A R E
Sbjct: 1453 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1512
Query: 2196 DSRTEDFQTPSPVLRSSRKIREES 2219
+++ Q + LR R++++ES
Sbjct: 1513 EAQKRQAQEEAERLR--RQVQDES 1534
Score = 39.7 bits (91), Expect = 0.047
Identities = 64/315 (20%), Positives = 125/315 (39%), Gaps = 31/315 (9%)
Query: 358 EAEFQNMSRELYRDLALHFADDISIKEKPAEKSKEKKV-------VKPVRKVQKVAQLSS 410
EAE +EL ++ A +D KE+ A++ E+ + R+++ A+
Sbjct: 2355 EAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2411
Query: 411 TECRTGSSHLISTSSWRDGQKLVKKILGPAPRMEPKEQRTASSDRGGRERTAKSGGHIGR 470
+ R + D Q+ K+ A + K RT + + + T I R
Sbjct: 2412 LKLRVAEMSRAQARAEEDAQRFRKQ----AEEIGEKLHRTELATQ--EKVTLVQTLEIQR 2465
Query: 471 AESDPRLDVLHRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRG 530
+SD + L R ER + K + E + +L S Q+E L
Sbjct: 2466 QQSDHDAERL-REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2524
Query: 531 ILDDLQLDSTAHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVIS---- 586
D L +Q+ +L+ A + +R+ ++ V S
Sbjct: 2525 EKDSLL--QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2582
Query: 587 KRRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQE----LYRKQKEAFTK 642
+RR ++ +E VR+++E ++ ++++ Q+E ++N+RL+E L + + A
Sbjct: 2583 RRRQHEAEEG----VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2638
Query: 643 VKNVPPSEPSATRRL 657
+ V S+ +AT+ L
Sbjct: 2639 SEEVTASQVAATKTL 2653
Score = 38.5 bits (88), Expect = 0.10
Identities = 72/383 (18%), Positives = 148/383 (38%), Gaps = 45/383 (11%)
Query: 383 KEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHLISTSSWRDGQ----KLVKKILG 438
+E E ++ + + + ++ +++A+ + R + +++ G+ K +I
Sbjct: 1824 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1883
Query: 439 PAPRMEPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERS------- 491
E + R + D + R + +A+ + RL L + ER
Sbjct: 1884 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1943
Query: 492 -RSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVE 550
R + + E I L +S E A K L +E+ I + + T + +Q +E
Sbjct: 1944 LRQRRQVEEEILALKASF------EKAAAGKAELELELGRIRSNAE--DTLRSKEQAELE 1995
Query: 551 LQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRK 610
Q+ A R +R + A E+ +++R +EV + + +E R+ +
Sbjct: 1996 AARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRKAALEEVERLKAKVEEARRLR 2052
Query: 611 QNEEKKAQKE---ATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKL--- 664
+ E+++ ++ A E KRLQ ++ AF V E + LQ+ S L
Sbjct: 2053 ERAEQESARQLQLAQEAAQKRLQA--EEKAHAFA----VQQKEQELQQTLQQEQSVLDQL 2106
Query: 665 ----LLEKTLLEEPSHQHVTQETQAKPGYQPSGESDK-----ENKVQERPPSASSSSDMS 715
+ EE V E +A + E+++ E + Q R A ++++
Sbjct: 2107 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-AQAQAAAEKL 2165
Query: 716 LSEPPQPLARKDLMESTWMQPER 738
E Q AR+ E ++ ++
Sbjct: 2166 RKEAEQEAARRAQAEQAALRQKQ 2188
Score = 33.1 bits (74), Expect = 4.4
Identities = 61/334 (18%), Positives = 124/334 (37%), Gaps = 44/334 (13%)
Query: 389 KSKEKKVVKPVRKVQKVAQLSST-----ECRTGSSHLISTSSWRDGQKLVKKILGPAPRM 443
K++ + V P +K + + S + RT S L + +S + +K I RM
Sbjct: 1317 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-----QYIKFISETLRRM 1371
Query: 444 EPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERSRSK--SRSENNI 501
E +E+ RER A+ + E +L H + +ER + R + +
Sbjct: 1372 EEEERLAEQQRAEERERLAEVEAAL---EKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1428
Query: 502 KKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVELQNQKSSAPVH 561
+ + D +Q++ + + E++ + + + A + + E + +
Sbjct: 1429 VRREEAAVDAQQQKRS------IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1482
Query: 562 A--------PRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNE 613
R + + + A + KR+ + E + V+ + +RKR+
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1542
Query: 614 EK----KAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKT 669
E KA+ EA +K + LQ L + +A A RRL++ + +
Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRLQA-----------EEAERRLRQAEVERARQVQ 1591
Query: 670 LLEEPSHQHVTQETQAKPGYQPSGESDKENKVQE 703
+ E + + E Q+K + E +QE
Sbjct: 1592 VALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1625
Score = 32.7 bits (73), Expect = 5.8
Identities = 52/267 (19%), Positives = 107/267 (40%), Gaps = 35/267 (13%)
Query: 2619 SVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKENKDLI-SDATEKV 2677
S +D E L+ E + +Q + +L+ + +V + +E + L S +EK
Sbjct: 2468 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2527
Query: 2678 S-------IAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQL 2730
S I E L+ F +E+ K QQ EE+ + + +E+ +L
Sbjct: 2528 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ------------MEQERQRL 2575
Query: 2731 EAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLG 2790
A ++ + + ++++ + + ++ + QL+Q ++ ++E + NQ L
Sbjct: 2576 VASMEEARRRQHEAEEGVRR------------KQEELQQLEQQRRQQEELLAEENQR-LR 2622
Query: 2791 DDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDEKEEISSPDMCPRPESPVFGASGQEEL 2850
+ + + Q + + + S + L + ++ + P PE F ++
Sbjct: 2623 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS-FDGLRRKVS 2681
Query: 2851 AKRLAELE-LSREFLSALGDDQDWFDE 2876
A+RL E LS E L L DE
Sbjct: 2682 AQRLQEAGILSAEELQRLAQGHTTVDE 2708
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 90.1 bits (222), Expect = 3e-17
Identities = 225/1165 (19%), Positives = 457/1165 (39%), Gaps = 222/1165 (19%)
Query: 1372 QQQRHERDLALLKLKAEQEALESQRQLEETRN------------KAAQVHAE--SLQQVV 1417
QQQ + D + AE ++LE Q + +T N KAAQ+ E ++
Sbjct: 120 QQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKY 179
Query: 1418 QSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELTRTHISDAVVASGA----- 1472
+R + E ++ ++ + ++ A + D ++ L R I D V
Sbjct: 180 DEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL-----LQRPGIEDVAVLKKELVQVQ 234
Query: 1473 ----PLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLD-----SKHQKYS 1523
+ + + + + L D K+L+++ + + S S+ +G + + QK
Sbjct: 235 TLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLK 294
Query: 1524 ASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSID------EQV 1577
+S + ++ KN + Q+ + K NE+ ++ + I++++ +Q+
Sbjct: 295 SSVNELTQ----KNQTLTENLLKKEQDYTKLEE-KHNEESVSKKNIQATLHQKDLDCQQL 349
Query: 1578 Q---TAADDSL---------RSDSVPSLPDEKDSTSIATEYS-LKFDESMTEDEIEEQSF 1624
Q +A++ SL + ++ L +E + + T+Y LK + + + EE+
Sbjct: 350 QSRLSASETSLHRIHVELSEKGEATQKLKEE--LSEVETKYQHLKAEFKQLQQQREEKEQ 407
Query: 1625 RSL-LPS-----------------ESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELN 1666
L L S E+H R +++ D+E L ++ L
Sbjct: 408 HGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSR-LE 466
Query: 1667 MPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLRE-------------------- 1706
+ ++ ++ + + +E +A QS+ +LRE
Sbjct: 467 EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ 526
Query: 1707 --KALKEKTKAELAWLEHQKKHLRDK-----GEDDKMPPLRKKQRGLLLRLQQEKAEIKR 1759
+AL +K+K ++ LE +++ L K GE + L++K L ++ Q ++K
Sbjct: 527 NLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKN 586
Query: 1760 LQEANKAA--------RKERQLILKQQEEIEKIRQTTIKLQEKLKSAGE--SKLDSHSDD 1809
E++K A ++++ + Q+ + + + +L +L + E S+LD
Sbjct: 587 QSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA 646
Query: 1810 DTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMD--------------- 1854
T+ + T + + + + Q+L K+ +++D
Sbjct: 647 KTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ 706
Query: 1855 -EKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKE 1913
E L + ++K + Q EEL ++L+A+ E++ ++QAL ++L + + +
Sbjct: 707 LESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL----QDLQQQRQLNTD 762
Query: 1914 LEDQRTE---QKEIASEEESPVPLYSHLNSES--SIPEELGSPAVE----------YVPS 1958
LE + TE Q E+ E S L SE+ SI ++L E
Sbjct: 763 LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQE 822
Query: 1959 ESIGQEQPGSPDHSILTEEMICSQELE---SSTSPSKHSLPKSCTSVSKQESSKGSHRTG 2015
I E+ + + +TE E E + S K L K S+ +S
Sbjct: 823 TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQK 882
Query: 2016 GQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQ 2075
G+ + + + C + L + T +Q + LK L K K +QLK E
Sbjct: 883 GKAAI-LDLEKTCKELKHQ-LQVQMENTLKEQKE-------LKKSLEKEKEASHQLKLEL 933
Query: 2076 KKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSS-------- 2127
Q++ ++AQ + +KQ E ++ ++ EL Q +S K QI+ L
Sbjct: 934 NSMQEQLIQAQ--NTLKQNEKEEQQLQGNINELKQ---SSEQKKKQIEALQGELKIAVLQ 988
Query: 2128 -------------------ASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEH 2168
A+EK KI L + ++ + +K L R S E +A
Sbjct: 989 KTELENKLQQQLTQAAQELAAEKEKISVLQN-NYEKSQETFKQLQSDFYGRES-ELLATR 1046
Query: 2169 VDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIRE----ESGDSLE 2224
D + S+++ L + ++ + ++ +T L +E E +L+
Sbjct: 1047 QDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQ 1106
Query: 2225 NVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVL 2284
++ LKE V E SK +EI+EI K ++ K ++E KS L
Sbjct: 1107 DIQKEKSLKEKEL-----------VNEKSKLAEIEEI---KCRQEKEITKLNEELKSHKL 1152
Query: 2285 --LKLVLEQGDSSEILSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKER-QSDQDMNHS 2341
+K + D+ ++L ++ L L + D + A+E +++++LK++ + +++
Sbjct: 1153 ESIKEITNLKDAKQLLIQQKLELQG---KADSLKAAVEQEKRNQQILKDQVKKEEEELKK 1209
Query: 2342 PNIQSGKDIHEQKNTKEKDLSWSEH 2366
I+ +H + KEK++ +H
Sbjct: 1210 EFIEKEAKLHSE--IKEKEVGMKKH 1232
Score = 87.0 bits (214), Expect = 3e-16
Identities = 216/1157 (18%), Positives = 453/1157 (39%), Gaps = 140/1157 (12%)
Query: 1379 DLALLKLKAE--QEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAA 1436
D+ LL+ + + Q +L+ ++ E K + + QQ + VT+ A +
Sbjct: 84 DVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTD--SSAELQSLE 141
Query: 1437 QQSETARLTTDAARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRT 1496
QQ E A+ +Q+ ++ E ++ + A + YD +R R
Sbjct: 142 QQLEEAQTENFNIKQMKDLFEQKAAQLATEI----ADIKSKYDEERS----------LRE 187
Query: 1497 ETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPS 1556
++K ++ +KE T+ + + + K +E V +
Sbjct: 188 AAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLK------------KELVQVQT 235
Query: 1557 CKEN---EKKLNGEKIESSIDE-QVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDE 1612
+N E++ EK++ + Q Q A+ ++ S L ++ + K
Sbjct: 236 LMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKS 295
Query: 1613 SMTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGG 1672
S+ E + Q+ L + +E++ +EE+ +K +T + ++
Sbjct: 296 SVNELTQKNQTLTENLLKKEQDYTKLEEKH------NEESVSKKNIQATLHQKDLDCQQL 349
Query: 1673 QDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGE 1732
Q S + R +++ E A Q K K EL+ +E + +HL+ + +
Sbjct: 350 QSRLSASETSLHRIHVELSEKGEATQ-------------KLKEELSEVETKYQHLKAEFK 396
Query: 1733 DDKMPPLRKKQRGLLLRLQQEKAEIKRLQ------EANKAARKERQL----ILKQQEEIE 1782
+ K+Q GL L+ + + K L+ EA+ +++RQL ++ +++++
Sbjct: 397 QLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVA 456
Query: 1783 KIRQTTIKLQEKLKSAGESKLD-SHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSS 1841
++ +L+E+LK + + H D TK L+ + + + + ++
Sbjct: 457 DLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQA---LQQSTTAKLREAQNDLEQ 513
Query: 1842 IMQKL--KKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEK----- 1894
+++++ K + + E L K ++ + + E+L + + E A + Q+++
Sbjct: 514 VLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTL 573
Query: 1895 -----QALAAWDKELIKPKTPKKELEDQRTEQK--------EIASEEESPVPLYSHLNSE 1941
Q + K ++ L DQ EQK + S E S L S LN
Sbjct: 574 QEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNES 633
Query: 1942 SSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTS 2001
+L ++ + E + + L + +Q + +
Sbjct: 634 KEKVSQL-DIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQ 692
Query: 2002 VSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALK-DE 2060
V+ + K H + + HL + ++ LS+ Q ++EG+I+ L+ D
Sbjct: 693 VTAKLQDKQEHCSQLESHLK--------EYKEKYLSLEQK-----TEELEGQIKKLEADS 739
Query: 2061 LRKRKSVVNQLKKEQKKRQ-KERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAK 2119
L + S L+ Q++RQ L+ + L KQLE E + T +L + E + K
Sbjct: 740 LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK 799
Query: 2120 PQI-----------KTLSSASEKPKIKPLTPLHRSET--AKNWKSLTESERSRGSLESIA 2166
++ + + S++ KI+ +R +T + K E E L ++
Sbjct: 800 QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859
Query: 2167 E---HVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSL 2223
+ V SL S+ + + A ++ + E + ++ K ++E SL
Sbjct: 860 DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL 919
Query: 2224 E-NVPALHLLK-ELNATSRILDMSDGKVGESSKKSE-----IKEIEYTKLKKSKIEDAFS 2276
E A H LK ELN+ L + + ++ K+ + I E++ + +K K +A
Sbjct: 920 EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQ 979
Query: 2277 KEGKSDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQ 2336
E K VL K LE +++ + +K+ + + N KS+E K+ QSD
Sbjct: 980 GELKIAVLQKTELE----NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
Query: 2337 DMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSED---FEVSSFKKEISAELY 2393
S + + +D+ K+ +EK E L + + +++ E+ + K + +
Sbjct: 1036 YGRESELLATRQDL---KSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSA 1092
Query: 2394 KDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEISECLSEKSLS-IHSNVHS 2452
K + ++ +D Q ++K + + + EEI +C EK ++ ++ + S
Sbjct: 1093 KKEQQLQERCKALQDIQ--KEKSLKEKELVNEKSKLAEIEEI-KCRQEKEITKLNEELKS 1149
Query: 2453 DRLLELKSPTELMKSKE 2469
+L +K T L +K+
Sbjct: 1150 HKLESIKEITNLKDAKQ 1166
Score = 71.2 bits (173), Expect = 1e-11
Identities = 190/1017 (18%), Positives = 406/1017 (39%), Gaps = 115/1017 (11%)
Query: 1327 HRMAAELSYLNAIEESVRQ-LSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKL 1385
HR+ ELS + +++ LS+VE + A+ + QQQR E++ L+L
Sbjct: 361 HRIHVELSEKGEATQKLKEELSEVET--------KYQHLKAEFKQLQQQREEKEQHGLQL 412
Query: 1386 KAE-----QEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSE 1440
++E + LE++RQL E + + S ++++ +++V + LQ ++ Q E
Sbjct: 413 QSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVAD-LQLKLSRLEEQLKE 471
Query: 1441 TARLTTDAARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDR 1500
+T+ Q+ + T+ + + A L + Q D + LR + D+
Sbjct: 472 KVTNSTELQHQL----DKTKQQHQEQQALQQSTTAKLREAQN----DLEQVLRQIGDKDQ 523
Query: 1501 KSPSVS--LSQSKE--GTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPS 1556
K ++ L +SKE L+ + + A + + N + + Q +
Sbjct: 524 KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK 583
Query: 1557 CKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTE 1616
K N+ + + + E+ D+ + A D V SL + + S E +++
Sbjct: 584 LK-NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNES---KEKVSQ 639
Query: 1617 DEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEK-----TTLSTAKELNMPFSG 1671
+I+ ++ LL S + +H D+ + A +K + ++
Sbjct: 640 LDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQD 699
Query: 1672 GQDSFSKF---TMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLR 1728
Q+ S+ E +Y+ E+ + + +L +L+ K E A + Q++
Sbjct: 700 KQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQL 759
Query: 1729 DKGEDDKMPPLRKKQR-------GLLLRLQQEKAEIKRLQEANKAARKERQLILK----- 1776
+ + + L K+ L LQ++ ++ +++ +E+Q++ +
Sbjct: 760 NTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETL 819
Query: 1777 ------QQEEIEKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPS 1830
Q EE+ QTT+ +K+K E+ + S K +K +D S S
Sbjct: 820 SQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKV-----SDSLKNSKS 874
Query: 1831 PISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIR 1890
+ + + + L+K + + + E L ++++ + L + K + E+
Sbjct: 875 EFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELN 934
Query: 1891 QMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGS 1950
M++Q + A L + + +++L+ E K+ + +++ + ++ EL
Sbjct: 935 SMQEQLIQA-QNTLKQNEKEEQQLQGNINELKQSSEQKKKQI---------EALQGELKI 984
Query: 1951 PAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKG 2010
++ E+ Q+Q + E+ S L+++ S+ + + + +ES
Sbjct: 985 AVLQKTELENKLQQQLTQAAQELAAEKEKIS-VLQNNYEKSQETFKQLQSDFYGRESELL 1043
Query: 2011 SHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQ 2070
+ R +KS +E LS+ Q + S+++ I G L EL+ K+ + Q
Sbjct: 1044 ATRQ------DLKS-------VEEKLSLAQEDLISNRNQI-GNQNKLIQELKTAKATLEQ 1089
Query: 2071 LKKEQKKRQKERLKA-QEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSAS 2129
+++++ +ER KA Q+ K L+ K+ E S+ E Q K ++ +
Sbjct: 1090 DSAKKEQQLQERCKALQDIQKEKSLKE-----KELVNEKSKLAEIEEIKCRQEKEITKLN 1144
Query: 2130 EKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYA 2189
E+ K L + K+ K L ++ L+ A+ + A++ +R +++ L
Sbjct: 1145 EELKSHKLESIKEITNLKDAKQLLIQQKL--ELQGKADSLKAAVEQEKR--NQQILKDQV 1200
Query: 2190 KRVNEWDSRTEDFQTPSPVLRSSRKIRE------ESGDSLENVPALHLLKELNATSRILD 2243
K+ E + ++F L S K +E E ++ + L + L +
Sbjct: 1201 KK--EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQ 1258
Query: 2244 MSDGKVGESSK-----KSEIKEIEYT-----KLKKSKIEDAFSKEGKSDVLLKLVLE 2290
S +V E K + EI +E T +++ +E EG+ + L VLE
Sbjct: 1259 SSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLE 1315
Score = 65.5 bits (158), Expect = 8e-10
Identities = 273/1402 (19%), Positives = 544/1402 (38%), Gaps = 316/1402 (22%)
Query: 1770 ERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSP 1829
E L LK+ +++ +RQ LQ LK + ++ K G E +
Sbjct: 75 ESNLALKR-DDVTLLRQEVQDLQASLKE------EKWYSEELKKELEKYQGLQQQEAKPD 127
Query: 1830 SPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQRR--QHAEELLEWKRRLDAEEA 1887
++ SS+E S+ Q+L++ ++ E F K+ + L +++ Q A E+ + K + D EE
Sbjct: 128 GLVTDSSAELQSLEQQLEEAQT---ENFNIKQMKDLFEQKAAQLATEIADIKSKYD-EER 183
Query: 1888 EIRQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEE 1947
+R+ +Q + +EL K T ++D +TE +
Sbjct: 184 SLREAAEQKVTRLTEELNKEATV---IQDLKTELLQ------------------------ 216
Query: 1948 LGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQES 2007
+PG D ++L +E++ Q L + + E
Sbjct: 217 -----------------RPGIEDVAVLKKELVQVQTLMDNMT---------------LER 244
Query: 2008 SKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSV 2067
+ S + +C K Q Y+ S+ ++S +SE ++ ++ EL+K KS
Sbjct: 245 ERESEKLKDEC----KKLQSQYASSEATISQLRSELAKGPQEVAVYVQ----ELQKLKSS 296
Query: 2068 VNQL-KKEQKKRQKERLKAQEASLIKQLESYDEFIKKT-EAELSQ-DLETSPTAKPQIKT 2124
VN+L +K Q + K Q+ + +++ + + KK +A L Q DL+ Q+++
Sbjct: 297 VNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ-----QLQS 351
Query: 2125 LSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERS 2184
SASE T LHR HV+ S G +
Sbjct: 352 RLSASE-------TSLHRI------------------------HVELSEKGEATQKLKEE 380
Query: 2185 LSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDM 2244
LS E +++ + + L+ R+ +E+ G L L E+N L
Sbjct: 381 LS-------EVETKYQHLKAEFKQLQQQREEKEQHG--------LQLQSEINQLHSKLLE 425
Query: 2245 SDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLV-LEQGDSSEILSKKDL 2303
++ ++GE+ + + E +L K+ D ++ +D+ LKL LE+ ++ + +L
Sbjct: 426 TERQLGEAHGRLK----EQRQLSSEKLMD--KEQQVADLQLKLSRLEEQLKEKVTNSTEL 479
Query: 2304 PLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHE---QKNTKEKD 2360
L K+++ +E+Q+ Q + ++ D+ + Q K++
Sbjct: 480 Q---------------HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK 524
Query: 2361 LSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMR 2420
+ E L + S + ++++ A++ + E + L L++ + + +++ +
Sbjct: 525 IQNLEALLQKSKENISL---LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLT 581
Query: 2421 SSTSGATSFGSNEEISECLSEK--SLSIHSNVHSDRLLELKSP-----TELMKSKERSDV 2473
+ S+++ E L ++ H DR+L L++ ++L +SKE+
Sbjct: 582 EKLKNQSE--SHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQ 639
Query: 2474 EHEQQVTESPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDK 2533
Q ++ L S A Q L+ +T+ DK
Sbjct: 640 LDIQIKAKTELLLSAEAAK--------------TAQRADLQNHLDTA------QNALQDK 679
Query: 2534 PEGNNNGT--YDGI-AYFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQC 2590
+ N T D + A + K++H Q SH+ E + Y+ + + + + Q
Sbjct: 680 QQELNKITTQLDQVTAKLQDKQEHC----SQLESHLKEYKEKYLSLEQKTE---ELEGQI 732
Query: 2591 YNQEQNDTEGPKDREKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNVQDISGVLEAH 2650
E + E +E+ + + ++ L + ++ A+ S+ L++E + V L+
Sbjct: 733 KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRAT-ELSKQLEMEKEIVSSTRLDLQKK 791
Query: 2651 VHQQSSVDSQISSKE------------------------NKDLISDATEKVSIAAEDDTL 2686
S+ +++ +E N + + TE + E + L
Sbjct: 792 SEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEAL 851
Query: 2687 D---NTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDL---LTREKNQLEAQLKSSLNE 2740
+T ++L K + + + + ++K +LDL K+QL+ Q++++L E
Sbjct: 852 MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911
Query: 2741 EKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKVTPQD 2800
+K+ K+ LEK + LK+ + QL Q + T + + Q+L G+ +
Sbjct: 912 QKELKKSLEKEKEASHQ-LKLELNSMQEQLIQAQNTLKQN-EKEEQQLQGN------INE 963
Query: 2801 LSQNVEEQSPSISGCFLSSELED---EKEEISSPDMCPRPESPVFGASGQEELAKRLAEL 2857
L Q+ E++ I L EL+ +K E+ + Q++L + EL
Sbjct: 964 LKQSSEQKKKQIEA--LQGELKIAVLQKTELEN--------------KLQQQLTQAAQEL 1007
Query: 2858 ELSREFLSALGDDQDWFDEDFGLSSSHKIQKNKAEETIVPLMAEPKRVTQQPCETLLAVP 2917
+E +S L ++ + K++ET L ++ + LLA
Sbjct: 1008 AAEKEKISVLQNNYE-----------------KSQETFKQLQSDFYGRESE----LLATR 1046
Query: 2918 HTAEEVEILVHNAAEELWKWK-ELGHDLHSISIPTKLLGCASKGLDIESTSKRVYKQ--- 2973
+ VE + A E+L + ++G+ I + L A L+ +S K Q
Sbjct: 1047 QDLKSVEEKLSLAQEDLISNRNQIGNQNKLI----QELKTAKATLEQDSAKKEQQLQERC 1102
Query: 2974 -AVFDLTKEIF---EEIFAEDPNLNQPVWMKPCR-----------INSSYFRRVKNPNNL 3018
A+ D+ KE +E+ E L + +K CR + S +K NL
Sbjct: 1103 KALQDIQKEKSLKEKELVNEKSKLAEIEEIK-CRQEKEITKLNEELKSHKLESIKEITNL 1161
Query: 3019 DEIKSFIASEVLKL----FSLKKEPNHKTDWQKMMKFGRKKRD--------RVDHILVQE 3066
+ K + + L+L SLK + Q+++K KK + + L E
Sbjct: 1162 KDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSE 1221
Query: 3067 LHEEEAQWVNYDEDELCVKMQL 3088
+ E+E ++E+E + MQ+
Sbjct: 1222 IKEKEVGMKKHEENEAKLTMQI 1243
Score = 62.0 bits (149), Expect = 9e-09
Identities = 172/965 (17%), Positives = 375/965 (38%), Gaps = 132/965 (13%)
Query: 1328 RMAAELSYLNA-IEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLK 1386
++ +E++ L++ + E+ RQL + L +Q +S +++ +QQ + L L +L+
Sbjct: 411 QLQSEINQLHSKLLETERQLGEAHG----RLKEQRQLSSEKLMDKEQQVADLQLKLSRLE 466
Query: 1387 AE-QEALESQRQLEETRNKAAQVHAE--SLQQVV-----QSQREVTEVLQEATCKIAAQQ 1438
+ +E + + +L+ +K Q H E +LQQ ++Q ++ +VL++ K Q
Sbjct: 467 EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ 526
Query: 1439 SETARLTTDAARQICEMAELTRTHISDAVVASGAPLAILYDHQRQH--LPDFVKQLRTRT 1496
+ A L +++ + E R + + A A+L Q ++ L + V QL +
Sbjct: 527 NLEALL--QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL 584
Query: 1497 ETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPS 1556
+ +S + + + K +A S + + + + + +
Sbjct: 585 KNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI 644
Query: 1557 CKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTE 1616
+ E L+ E +++ +Q D + + L D++ + T + + +
Sbjct: 645 KAKTELLLSAEAAKTAQRADLQNHLDTAQNA-----LQDKQQELNKITTQLDQVTAKLQD 699
Query: 1617 DEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSF 1676
+ S L + ++E++ + ++ + + +KE + QD
Sbjct: 700 KQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL-----QD-- 752
Query: 1677 SKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKM 1736
++ RQ + E+RA S L + EK + T+ +L QKK + K+
Sbjct: 753 ----LQQQRQLNTDLELRATELSKQLEM-EKEIVSSTRLDL-----QKKSEALESIKQKL 802
Query: 1737 PPLRKKQRGLLLRLQQEKAEIK-RLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKL 1795
++++ L + E K + +E N + + K + E E + +++KL
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
Query: 1796 KSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPS---PISISSSETSSIMQKLKKMRSR 1852
+S +S S+ + K+N+ DLE + + T ++LKK +
Sbjct: 863 SKVSDSLKNSKSEFE-KENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEK 921
Query: 1853 MDEKF------LTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQ---MEKQALAAWDKE 1903
E L +++L+Q + ++ + +++L E++Q +K+ + A E
Sbjct: 922 EKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE 981
Query: 1904 LIKPKTPKKELEDQRTEQ-----KEIASEEESPVPLYSHLNSESSIPEELGSP------- 1951
L K ELE++ +Q +E+A+E+E L ++ ++L S
Sbjct: 982 LKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESE 1041
Query: 1952 -------------AVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKS 1998
+ + I + ++ E LE ++ + L +
Sbjct: 1042 LLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQER 1101
Query: 1999 CTS---VSKQESSKGSHRTGGQCHLP-------------------IKSHQHCYSWSDESL 2036
C + + K++S K + L +KSH+ +L
Sbjct: 1102 CKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL 1161
Query: 2037 SMTQSETTSDQSDIEGRIRALK----DELRKRKSVVNQLKKEQKKRQKERLKAQEASLIK 2092
+ + +++G+ +LK E R ++ + +Q+KKE+++ +KE ++ +EA L
Sbjct: 1162 KDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIE-KEAKLHS 1220
Query: 2093 QLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSL 2152
+++ + +KK E E QI L+ + K W+S
Sbjct: 1221 EIKEKEVGMKKHE-------ENEAKLTMQITALNE-------------NLGTVKKEWQS- 1259
Query: 2153 TESERSRGSLESIAEHVDASLSGSERSV--SERSLSAYAKRVNEWDSRTEDFQTPSPVLR 2210
S+R LE + + ++ E +V ++ A +R + + E QT VL
Sbjct: 1260 --SQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQT--KVLE 1315
Query: 2211 SSRKI 2215
RK+
Sbjct: 1316 LQRKL 1320
Score = 33.1 bits (74), Expect = 4.4
Identities = 69/338 (20%), Positives = 143/338 (42%), Gaps = 47/338 (13%)
Query: 381 SIKEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHLISTSSWRDGQKLVKK-ILGP 439
SIK+K ++ +EK+++K + + ++Q + + ++ + +T + K+ K+ ++
Sbjct: 797 SIKQKLTKQEEEKQILK--QDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTE 854
Query: 440 APRMEPKEQRTASSDRGGRERTAKSG--GHIGRAESDPRLDVLHRHLQRNSERSRSKSRS 497
++ K + + S + + K G + + L LQ E + +
Sbjct: 855 LSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQ-- 912
Query: 498 ENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVELQNQKSS 557
K+L SL K+ + L +E+ + + QL +T KQ+ E + Q+
Sbjct: 913 ----KELKKSLEKEKEASHQ------LKLELNSMQE--QLIQAQNTLKQN--EKEEQQLQ 958
Query: 558 APVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNEEKKA 617
++ + S K+K +I A + E++ ++++ E + Q + +A
Sbjct: 959 GNINELKQSSEQKKK--QIEALQG-------------ELKIAVLQKTELENKLQQQLTQA 1003
Query: 618 QKEATEQKNKR--LQELYRKQKEAFTKVKN---VPPSEPSATRR-LQETYSKLLLEKTLL 671
+E +K K LQ Y K +E F ++++ SE ATR+ L+ KL L + L
Sbjct: 1004 AQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDL 1063
Query: 672 EEPSHQ-----HVTQETQAKPGYQPSGESDKENKVQER 704
+Q + QE + + KE ++QER
Sbjct: 1064 ISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQER 1101
>gi|18496983 CAP-GLY domain containing linker protein 3 [Homo sapiens]
Length = 547
Score = 89.7 bits (221), Expect = 4e-17
Identities = 48/143 (33%), Positives = 78/143 (54%), Gaps = 6/143 (4%)
Query: 2429 FGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESPSLASV 2488
F S +IS+ + S+ S + R+ + K R + + +++ SPSL S+
Sbjct: 354 FASVSKISKAVDAPPSSVTSTPRTPRM-----DFSRVTGKGRREHKGKKKTPSSPSLGSL 408
Query: 2489 PTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYF 2548
D +GD+VL+ + GI+RF G+T FA G+W G+ELD+P G ++G+ G+ YF
Sbjct: 409 QQRDGA-KAEVGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSVFGVRYF 467
Query: 2549 ECKEKHGIFAPPQKISHIPENFD 2571
C +HG+FAP +I I + D
Sbjct: 468 TCPPRHGVFAPASRIQRIGGSTD 490
Score = 78.2 bits (191), Expect = 1e-13
Identities = 36/66 (54%), Positives = 44/66 (66%)
Query: 2499 IGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFA 2558
+GDRVL+ + G LRF G T FA G W GVELD+PEG N+G+ G+ YF C K G+FA
Sbjct: 296 LGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLFA 355
Query: 2559 PPQKIS 2564
KIS
Sbjct: 356 SVSKIS 361
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 84.3 bits (207), Expect = 2e-15
Identities = 207/1099 (18%), Positives = 403/1099 (36%), Gaps = 163/1099 (14%)
Query: 1328 RMAAELSYLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKA 1387
R+ E EE R+ + R + QQE Q+ + Q++R E+ L + +
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQL---RREQ 355
Query: 1388 EQEALESQ--RQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLT 1445
E+E E Q R+ EE R + + L++ Q +RE ++ +E + Q +L
Sbjct: 356 EEERREQQLRREQEEERREQQLRREQQLRREQQLRRE-QQLRREQQLRREQQLRREQQLR 414
Query: 1446 TDAARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQ------------LR 1493
+ +Q+ +L R + H+++H + +Q L+
Sbjct: 415 RE--QQLRREQQLRREQEEER-------------HEQKHEQERREQRLKREQEERRDWLK 459
Query: 1494 TRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPS 1553
ET+R Q K + + +++ E + +RR QE
Sbjct: 460 REEETERHEQERRKQQLKRDQEEERRERWL----KLEEEERREQQERREQQLRREQEERR 515
Query: 1554 VPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDES 1613
K E++ E+++ + + Q + R + + +EK E LK ++
Sbjct: 516 EQRLKRQEEE---ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQE 572
Query: 1614 MTEDEI---------------EEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTT 1658
D++ +E+ L E R E+RR +E +
Sbjct: 573 ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQ 632
Query: 1659 LSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELA 1718
L ++E Q+ + + +Q +E+ ++ + L R K E+ + E
Sbjct: 633 LLKSEE--------QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE 684
Query: 1719 WLEHQKKHLRDK-----------------GEDDKMPPLRKKQRGLLLRLQQEKAEIKRLQ 1761
E +++ R++ K+ +KQ G R +QE+ KR +
Sbjct: 685 LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE---KRRR 741
Query: 1762 EANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSA-GESKLDSHSDDDTKDNKATSPG 1820
++ +E + +QQ+E E+ R T + Q + KS G +L + ++ +
Sbjct: 742 RESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPP--LREQRERQLR 799
Query: 1821 PTDLETRSPSPISISSSETSSIMQKLKKMRSRMDE-KFLTKREQKLMQRRQHAEELLEWK 1879
+ + R + E Q+ ++ R R E +FL + EQ +QRR+ A++L E +
Sbjct: 800 AEERQQREQRFLP----EEEEKEQRRRQRREREKELQFLEEEEQ--LQRRERAQQLQEEE 853
Query: 1880 RRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKE-------LEDQRTEQKEIASEEESPV 1932
L ++ R E++ W +L + + ++ L++Q +++++ EEE
Sbjct: 854 DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE-- 911
Query: 1933 PLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSK 1992
L E +Y E + QE+ E+++ + + +
Sbjct: 912 ----ELQREEREKRRRQEQERQYREEEQLQQEE----------EQLLREEREKRRRQERE 957
Query: 1993 HSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEG 2052
K K+E G + K ++ E + + E +
Sbjct: 958 RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE 1017
Query: 2053 RIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDL 2112
R KDEL++ + QL +E+ R+K RL+ +E +Q +E ++ E L ++
Sbjct: 1018 RQYRKKDELQQEEE---QLLREE--REKRRLQERE----RQYREEEELQQEEEQLLGEER 1068
Query: 2113 ETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDAS 2172
ET + Q E+ + L R E K + E ER E + + +
Sbjct: 1069 ETR---RRQELERQYRKEEELQQEEEQLLREEPEKRRRQ--ERERQCREEEELQQEEEQL 1123
Query: 2173 LSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLE-NVPALHL 2231
L + L + E E P R +++ + + E L
Sbjct: 1124 LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL 1183
Query: 2232 LKELNATSRILDMSDGKVGESSKKSEIKEIEYTK---LKKSKIEDAFSKEG-KSDVLLKL 2287
L+E E K+ + +E +Y + L++ K + + E +SD LK
Sbjct: 1184 LRE----------------EQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSD--LKW 1225
Query: 2288 VLEQGDSSEILSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSG 2347
E + + K EN Q L S+ L++RQS QD+ H Q
Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQ-------FRQLEDSQ--LRDRQSQQDLQHLLGEQQE 1276
Query: 2348 KD-IHEQKNTKEKDLSWSE 2365
+D E++ +++D + E
Sbjct: 1277 RDREQERRRWQQRDRHFPE 1295
Score = 79.3 bits (194), Expect = 5e-14
Identities = 304/1688 (18%), Positives = 613/1688 (36%), Gaps = 176/1688 (10%)
Query: 1339 IEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQ----QRHERDLALLKLKAEQEALES 1394
++E QL +ER Q+E ++ + QQ Q ER + + +QE E
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330
Query: 1395 Q---------RQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLT 1445
Q R+ EE R + + E ++ Q +RE E +E + Q +L
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390
Query: 1446 TD----AARQICEMAELTRTHISDAVVASGAPLAILYD-----HQRQHLPDFVKQ----- 1491
+ +Q+ +L R + + H+++H + +Q
Sbjct: 391 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450
Query: 1492 -------LRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSS 1544
L+ ET+R Q K + + +++ E + +RR
Sbjct: 451 QEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL----KLEEEERREQQERREQQ 506
Query: 1545 GSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIAT 1604
QE K E++ E+++ + + Q + R + + +EK
Sbjct: 507 LRREQEERREQRLKRQEEE---ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR 563
Query: 1605 EYSLKFDESMTEDEI---EEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLST 1661
E LK ++ D++ EE+ + L E R +R + ++E E+
Sbjct: 564 EQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKRE 623
Query: 1662 AKE----LNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAEL 1717
E + S Q+ + + +Q +E+ ++ + L R K E+ + E
Sbjct: 624 EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQ 683
Query: 1718 AWLEHQKKHLRDK-----------------GEDDKMPPLRKKQRGLLLRLQQEKAEIKRL 1760
E +++ R++ K+ +KQ G R +QE+ KR
Sbjct: 684 ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE---KRR 740
Query: 1761 QEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKS-AGESKLDSHSD-DDTKDNKATS 1818
+ ++ +E + +QQ+E E+ R T + Q + KS G +L + + ++ + +
Sbjct: 741 RRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRA 800
Query: 1819 PGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDE-KFLTKREQKLMQRRQHAEELLE 1877
E R E Q+ ++ R R E +FL + EQ +QRR+ A++L E
Sbjct: 801 EERQQREQR-------FLPEEEEKEQRRRQRREREKELQFLEEEEQ--LQRRERAQQLQE 851
Query: 1878 WKRRLDAEEAEIRQMEKQALAAWDKELIKPKT-------PKKELEDQRTEQKEIASEEES 1930
+ L ++ R E++ W +L + + K L++Q +++++ EEE
Sbjct: 852 EEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE- 910
Query: 1931 PVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSP 1990
L E +Y E + QE+ E+++ + +
Sbjct: 911 -----EELQREEREKRRRQEQERQYREEEQLQQEE----------EQLLREEREKRRRQE 955
Query: 1991 SKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDI 2050
+ K K+E G + K ++ E + + E +
Sbjct: 956 RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015
Query: 2051 EGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQ 2110
R KDEL++ + QL +E+ R+K RL+ +E +Q +E ++ E L +
Sbjct: 1016 WERQYRKKDELQQEE---EQLLREE--REKRRLQERE----RQYREEEELQQEEEQLLGE 1066
Query: 2111 DLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVD 2170
+ E T + Q E+ + L R E K + E ER E + + +
Sbjct: 1067 ERE---TRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQ--ERERQCREEEELQQEEE 1121
Query: 2171 ASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLE-NVPAL 2229
L + L + E E P R +++ + + E
Sbjct: 1122 QLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEE 1181
Query: 2230 HLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVL 2289
LL+E R + E ++ + K+ + ++S ++ + E ++ V V
Sbjct: 1182 QLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY 1241
Query: 2290 EQG-DSSEILSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGK 2348
+G ++ + +D L Q+DL L E + E + R +D H P +
Sbjct: 1242 CKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRD-RHFPE-EEQL 1299
Query: 2349 DIHEQKNTKEKDLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDD--FEVSSLLSLR 2406
+ EQK K +D E K++ E+ E ++E + +++ + LR
Sbjct: 1300 EREEQKEAKRRDRKSQEE----KQL-LREEREEKRRRQETDRKFREEEQLLQEREEQPLR 1354
Query: 2407 KDSQSCRDKPQPMRSSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMK 2466
+ + + + + +R G + + E+ +L + +L +
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFL----KEEQQLRCQEREQQLRQ 1410
Query: 2467 SKERSDVEHEQQVTESPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFW 2526
++R E EQQ++ ++ +R + Q LR + F +
Sbjct: 1411 DRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ--LRQERHRKFREEEQ 1468
Query: 2527 AGVELDKP----EGNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDC 2582
E ++ + + + +E+ F + S PE + E++
Sbjct: 1469 LLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPER----KFLEEEQQL 1524
Query: 2583 YSDERYQCYNQEQND---TEGPKDREKDVSEYFYEKSLPSVNDIEASVN---RSRSLKIE 2636
+ +R + + QE+ E + R +D F E+ E ++ R R ++E
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLE 1584
Query: 2637 TDNV--QDISGVLEAHVHQQSSVDSQISSKENKDLISDATEKVSIAAEDDTLDNTFSEEL 2694
V Q+ Q + Q ++ +D E++ E+ L
Sbjct: 1585 EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL-----HRQ 1639
Query: 2695 EKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQL--EAQLKSSLNEEKKSKQQLEKIS 2752
E+ ++F EEE L + E+ D RE+ QL E + + +E+ K + E+
Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQ 1699
Query: 2753 LLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLGD-DQKKVTPQDLSQNVEEQSPS 2811
L + F+++ QQ+++ E+ ++L + +Q+++ Q+ + + E+
Sbjct: 1700 LRRQERERKFLQEE----QQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ- 1754
Query: 2812 ISGCFLSSELEDEKEEISSPDMCPRPESPVFGASGQEELAKRLAELELSREFLSALGDDQ 2871
L E E+++ D R E + QE ++L E R+F Q
Sbjct: 1755 -----LRPEREEQQLRRQERDRKFREEEQL----RQEREEQQLRSQESDRKFREEEQLRQ 1805
Query: 2872 DWFDEDFGLSSSHKIQKNKAEETIVPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAA 2931
+ E+ L + K + EE + L + +R+ Q+ A A + +
Sbjct: 1806 E--REEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEK--SRREE 1861
Query: 2932 EELWKWKE 2939
+ELW+ +E
Sbjct: 1862 QELWQEEE 1869
Score = 67.8 bits (164), Expect = 2e-10
Identities = 147/808 (18%), Positives = 298/808 (36%), Gaps = 65/808 (8%)
Query: 1357 LAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQV 1416
LA+ E S Q Q+ R RD L + + E + E +R EE E
Sbjct: 148 LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDE 207
Query: 1417 VQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELTRTHISDAVVASGAPLAI 1476
Q +R L E K ++ + R D Q E E + + V+
Sbjct: 208 EQLRRRE---LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKR---ETVLRKEEEKLQ 261
Query: 1477 LYDHQRQH-LPDFVKQLRT--RTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESS 1533
+ QRQ L + +QLR R E R+ Q + +K E
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Query: 1534 GYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSL 1593
+ +RR R++ + E++L E+ E ++Q++ ++ R +
Sbjct: 322 R-EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE 380
Query: 1594 PDEKDSTSIATEYSLKFDESMTEDEI--EEQSFRSLLPSESHRRFNMEKRRGHHDDSDEE 1651
+ + E L+ ++ + ++ EQ R ++ E+ H+ E+
Sbjct: 381 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ 440
Query: 1652 ASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMK---------------EEEMRAA 1696
E+ L +E + ++ + E +Q +K EEE R
Sbjct: 441 ERREQR-LKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499
Query: 1697 HQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLRLQQEKAE 1756
+ +LR + + + + E ++ R + E +++ LL R ++++ E
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLE 559
Query: 1757 IKRLQEANKAARKERQ-LILKQQEEIEK---IRQTTIKLQEKLKSAGESKLDSHSDDDTK 1812
+R ++ K ++ER+ +LK++EE + R+ +L+++LK +L+ ++ +
Sbjct: 560 QERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLE---QEERR 616
Query: 1813 DNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQ---RR 1869
+ + P E R + E Q ++ + R +++ + E++ ++ +R
Sbjct: 617 EQRLKREEPE--EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR 674
Query: 1870 QHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKEL----------IKPKTPKKELEDQRT 1919
+H EE E + + E+ + R+ K + W +L + + K+E + +R
Sbjct: 675 EHEEERRE-QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQ 733
Query: 1920 EQKEIASEEESPVPLY--SHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEE 1977
EQ+E ES + + + E+ ++ E + + L E+
Sbjct: 734 EQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQ 793
Query: 1978 MICSQELESSTSPSKHSLP----KSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSD 2033
E + LP K ++E K + L + +
Sbjct: 794 RERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEE 853
Query: 2034 ESLSMTQSETTSDQSDIEGRIRALKDELRKRK--------SVVNQLKKEQKKRQKERLKA 2085
+ L Q S + + + R +E RKR+ ++ QL+KEQ+ Q+E +
Sbjct: 854 DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL 913
Query: 2086 QEASLIKQLESYDEFIKKTEAELSQDLE 2113
Q K+ E + E +L Q+ E
Sbjct: 914 QREEREKRRRQEQERQYREEEQLQQEEE 941
Score = 67.4 bits (163), Expect = 2e-10
Identities = 153/873 (17%), Positives = 330/873 (37%), Gaps = 59/873 (6%)
Query: 1370 KAQQQRHERDLALLK--LKAEQEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVL 1427
+ +Q R E +L + L E+ +++LE K ++ E Q + + +
Sbjct: 1046 RERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE 1105
Query: 1428 QEATCKIAAQQSETARLTTDAARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPD 1487
+E C+ + + R+ EL R + + V + + +++ +
Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQE 1165
Query: 1488 FVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSS 1547
+Q R E ++ + L + +E + ++Y + + + D S
Sbjct: 1166 LERQYREEEELQQEEEQL-LREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLK 1224
Query: 1548 RQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRS-------DSVPSLPDEKDST 1600
Q P KEN + N + +EQ + D LR + E+D
Sbjct: 1225 WQWEPE----KENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDRE 1280
Query: 1601 SIATEYSLKF----DESMTEDEIEEQSFRSLLPSESHRRFNMEKR--RGHHDDSDEEASP 1654
+ + +E E E ++++ R S+ ++ E+R + ++D +
Sbjct: 1281 QERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFRE 1340
Query: 1655 EKTTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLRE---KALKE 1711
E+ L +E + Q+ KF E +R +E+ + + LR +E K LKE
Sbjct: 1341 EEQLLQEREEQPLR---RQERDRKFREEELRH--QEQGRKFLEEEQRLRRQERERKFLKE 1395
Query: 1712 KTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKER 1771
+ + E Q + RD+ ++ L +++R R +E+ +++R + K +E+
Sbjct: 1396 EQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFR--EEEQQVRRQERERKFLEEEQ 1453
Query: 1772 QLILKQQEEIEKIRQTTIKLQEKLKSA---GESKLDSHSDDDTKDNKATSPGPTDLETRS 1828
QL +QE K R+ LQE+ + E ++ + + E RS
Sbjct: 1454 QL---RQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS 1510
Query: 1829 PSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAE 1888
P E + ++ + R + KFL + +Q ++R++ ++ + + R EE +
Sbjct: 1511 QEP------ERKFLEEEQQLHRQQRQRKFLQEEQQ--LRRQERGQQRRQDRDRKFREEEQ 1562
Query: 1889 IRQ-MEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEE 1947
+RQ E+Q L+ +++ K +E + +R EQ+ E+E + + + +E
Sbjct: 1563 LRQEREEQQLSRQERDR---KFRLEEQKVRRQEQERKFMEDEQQL---RRQEGQQQLRQE 1616
Query: 1948 LGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQES 2007
++ E + QE+ H + +E + + L ++E
Sbjct: 1617 RDR---KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEE 1673
Query: 2008 SKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSV 2067
+ G + L + + ++ L + E Q + + R + L+ + R+ + +
Sbjct: 1674 QL--LQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731
Query: 2068 VNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSS 2127
+ ++EQ +RQ+ K E ++ E ++ +++ E + E + + + L S
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRP-EREEQQLRRQERDRKFREEEQLRQEREEQQLRS 1790
Query: 2128 ASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSA 2187
K + L + + + + R E + ER R+
Sbjct: 1791 QESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQ 1850
Query: 2188 YAKRVNEWDSRTEDFQTPSPVLRS--SRKIREE 2218
+A + E +Q R RK+REE
Sbjct: 1851 FATQEKSRREEQELWQEEEQKRRQERERKLREE 1883
Score = 67.4 bits (163), Expect = 2e-10
Identities = 150/827 (18%), Positives = 317/827 (38%), Gaps = 115/827 (13%)
Query: 1340 EESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALESQRQL- 1398
+E RQ + E + QQE Q+++ ++++ R + + E+E + + QL
Sbjct: 1104 QERERQCREEEEL------QQEE---EQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154
Query: 1399 -EETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAE 1457
EE + Q ++ + Q+E ++L+E K ++ R + RQ +
Sbjct: 1155 REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214
Query: 1458 LTRTHISD-----------AVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVS 1506
SD AV + + Q + L D QLR R ++
Sbjct: 1215 RDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED--SQLRDRQS--QQDLQHL 1270
Query: 1507 LSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKEN-EKKLN 1565
L + +E + + +++ + E + +++ + R+ +E E+K
Sbjct: 1271 LGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRR 1330
Query: 1566 GEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFR 1625
++ + E+ Q + + P E+D E L+ E + EEQ R
Sbjct: 1331 RQETDRKFREEEQLLQE----REEQPLRRQERDRKF--REEELRHQEQGRKFLEEEQRLR 1384
Query: 1626 SLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMVR 1685
E R+F E+++ + +++ ++ +E + F + ++ R
Sbjct: 1385 R---QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441
Query: 1686 Q-----YMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLR 1740
Q +++EE+ + R E+ L+E+ + +L E +K L ++ + LR
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ------LR 1495
Query: 1741 KKQRGLLLR---LQQEKAEIKRLQEANKAARKERQLILKQQEEI----------EKIRQT 1787
+++R R L+ ++ E K L+E + R++RQ Q+E+ + R
Sbjct: 1496 RQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555
Query: 1788 TIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRS--PSPISISSSETSSIMQK 1845
+ +E+L+ E + S + D K + R + E +++
Sbjct: 1556 KFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQ 1615
Query: 1846 LKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAE----------------- 1888
+ + R DE+ L +RE++ + R++ + LE + +L +E E
Sbjct: 1616 ERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQL 1675
Query: 1889 IRQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEE-SPVPLYSHLNSESSIPEE 1947
+++ E+Q L +++ K + +++L Q E+K + E++ L E + +E
Sbjct: 1676 LQEGEEQQLRRQERDR-KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQE 1734
Query: 1948 LGSPAV-------------EYVPSESIGQEQPGSPDHSILTEEMICS----QELESSTSP 1990
+ + P Q + D EE + Q+L S S
Sbjct: 1735 TEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESD 1794
Query: 1991 SKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQS-D 2049
K + +++ + R G Y W +E L + + E Q D
Sbjct: 1795 RKFREEEQLRQEREEQQLRPQQRDGK------------YRWEEEQLQLEEQEQRLRQERD 1842
Query: 2050 IEGRIR---ALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQ 2093
+ R A +++ R+ + + Q ++EQK+RQ+ K +E + +Q
Sbjct: 1843 RQYRAEEQFATQEKSRREEQELWQ-EEEQKRRQERERKLREEHIRRQ 1888
Score = 63.9 bits (154), Expect = 2e-09
Identities = 139/771 (18%), Positives = 289/771 (37%), Gaps = 87/771 (11%)
Query: 1634 RRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEM 1693
RR ++RR D E P + +E + G++ K Q E+
Sbjct: 113 RRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEK-------QERLEQRD 165
Query: 1694 RAAHQSSLLRLREK-ALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLRLQQ 1752
R L R R++ +E+ +AE L+ K H E ++ P + +R LL L++
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQLQSCKGH-----ETEEFPDEEQLRRRELLELRR 220
Query: 1753 EKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLDSHSDDDTK 1812
+ E K+ Q R+ERQ + Q+EE ++ R+ L+++ E KL +
Sbjct: 221 KGREEKQQQ------RRERQDRVFQEEEEKEWRKRETVLRKE-----EEKLQEEEPQRQR 269
Query: 1813 DNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQ--RRQ 1870
+ + LE + + +++ +++R + +E+ ++E++ Q RR+
Sbjct: 270 ELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE 329
Query: 1871 HAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTEQ---KEIASE 1927
EE E + R + EE +Q+ ++ +E + + ++E E++R EQ +E
Sbjct: 330 QQEERREQQLRREQEERREQQLRRE-----QEEERREQQLRREQEEERREQQLRREQQLR 384
Query: 1928 EESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESS 1987
E + L E + E + + +EQ + + E+ + +E E
Sbjct: 385 REQQLRREQQLRREQQLRRE-----------QQLRREQQLRREQQLRREQQL-RREQEEE 432
Query: 1988 TSPSKHSLPKSCTSVSKQESSKGS---HRTGGQCHLPIKSHQHCYSWSDES-----LSMT 2039
KH + + +++ + + H + Q +E L +
Sbjct: 433 RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLE 492
Query: 2040 QSETTSDQSDIEGRIRALKDE--------------LRKRKSVVNQLKKEQKKRQKERLKA 2085
+ E Q E ++R ++E L++R QL++EQ++R+++ LK
Sbjct: 493 EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552
Query: 2086 QEASLI-----------KQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKI 2134
+E + +Q E D+ +K+ E Q L+ + Q + L ++ ++
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLK-----REQEERLEQRLKREEV 607
Query: 2135 KPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNE 2194
+ L R E + K E R L E + R ER KR E
Sbjct: 608 ERLEQEERRE--QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERR-EQRLKREEE 664
Query: 2195 WDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSK 2254
+ + + R +++ EE + + K D KV +
Sbjct: 665 EERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPR 724
Query: 2255 KSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDL 2314
K E + + +K + ++ + + + + E+ + + SE ++ L
Sbjct: 725 KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRL 784
Query: 2315 VGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSE 2365
+ ++ E + ++ P + + Q+ +EK+L + E
Sbjct: 785 SARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE 835
Score = 53.1 bits (126), Expect = 4e-06
Identities = 101/543 (18%), Positives = 216/543 (39%), Gaps = 53/543 (9%)
Query: 1705 REKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLRLQQEKAEIKRLQEAN 1764
+E L+++ + E + ++ RD+ +++ P R++Q+ R +QE+ + +++
Sbjct: 106 KESLLQDRRQEE----DQRRFEPRDRQLEEE-PGQRRRQK----RQEQERELAEGEEQSE 156
Query: 1765 KAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDL 1824
K R E++ ++ EE+ + RQ + +E + A E +L S +T++ P L
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREE--RRAEEEQLQSCKGHETEE----FPDEEQL 210
Query: 1825 ETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQR----RQHAEELLE--- 1877
R + E +K ++ R R D F + E++ +R R+ E+L E
Sbjct: 211 RRRELLELRRKGRE-----EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265
Query: 1878 -WKRRLDAEEAEIRQMEKQALAAWDKE--------------LIKPKTPKKELEDQRTEQK 1922
+R L EE ++R++E+Q L +E K + ++E +++R EQ+
Sbjct: 266 QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325
Query: 1923 EIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEE--MIC 1980
E ++E E ++L E + + +EQ L E +
Sbjct: 326 ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR 385
Query: 1981 SQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQ 2040
Q+L + + + +++ + + + L + + + E Q
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445
Query: 2041 SETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKER-LKAQEASLIKQLESYDE 2099
+ + R + E +++ QLK++Q++ ++ER LK +E +Q E ++
Sbjct: 446 RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQ 505
Query: 2100 FIKKTEAELSQD----LETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTES 2155
+++ + E + E + ++++ + + + L R E K L +
Sbjct: 506 QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE----KRLEQE 561
Query: 2156 ERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKI 2215
R + E D L E +R +R+ + R E + R R
Sbjct: 562 RREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK 621
Query: 2216 REE 2218
REE
Sbjct: 622 REE 624
Score = 48.1 bits (113), Expect = 1e-04
Identities = 55/281 (19%), Positives = 111/281 (39%), Gaps = 26/281 (9%)
Query: 439 PAPRMEPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERSRSKSRSE 498
P R K Q G E++ K + + + R + L R Q ER ++ E
Sbjct: 133 PGQRRRQKRQEQERELAEGEEQSEKQE-RLEQRDRQRRDEELWRQRQEWQEREERRAEEE 191
Query: 499 NNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDD-----------LQLDSTAHTAKQD 547
++ + +E ++ L + +G + Q + K++
Sbjct: 192 Q-LQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRE 250
Query: 548 TVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVR----QYIVRQ 603
TV L+ ++ P+ ++ + +++ E + +R+ + + R Q + R+
Sbjct: 251 TV-LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRK 309
Query: 604 QEERKRKQNEEKKAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSK 663
QEE +R+Q EE++ Q+E EQ+ +R ++ R+++E E R +E +
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQE--------ERREQQLRREQEEERRE 361
Query: 664 LLLEKTLLEEPSHQHVTQETQAKPGYQPSGESDKENKVQER 704
L + EE Q + +E Q + Q E + Q R
Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLR 402
Score = 47.4 bits (111), Expect = 2e-04
Identities = 66/323 (20%), Positives = 128/323 (39%), Gaps = 38/323 (11%)
Query: 427 RDGQKLVKKILGPAPRMEPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQR 486
R Q+ K+ L E +E+ + RE+ + + R + + R L R Q
Sbjct: 466 RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKR--QE 523
Query: 487 NSERSRSKSRSENNIKKLASSLPDN--KQEENTALNKDFLPIEIRGILDDL--QLDSTAH 542
ER + + RSE +++ + K+EE L ++ ++ ++ QL
Sbjct: 524 EEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREE 583
Query: 543 TAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVR 602
+Q ++ + ++ R +KR+ + E+ +R +E RQ +++
Sbjct: 584 ERRQQRLKREQEE--------RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLK 635
Query: 603 QQEERKRKQNEEKKAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYS 662
+E+ +R+Q + ++ Q+E EQ+ KR +E E +RL+ +
Sbjct: 636 SEEQEERRQQQLRREQQERREQRLKREEE------------------EERLEQRLKREHE 677
Query: 663 KLLLEKTLLEEPSHQHVTQETQAKPGYQPSGESD---KENKVQERPPSASSSSDMSLSEP 719
+ E+ L EE Q + P +Q ES+ +++KV RP E
Sbjct: 678 EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737
Query: 720 PQPLARKDLMESTWMQPERLSPQ 742
+ R+ E W + ER Q
Sbjct: 738 KR---RRRESELQWQEEERAHRQ 757
Score = 45.8 bits (107), Expect = 7e-04
Identities = 100/565 (17%), Positives = 207/565 (36%), Gaps = 92/565 (16%)
Query: 253 RLTDSSPSSTSTSNSQRLDILKRRQHDVKLEKLKERIRKQWEHSEETNGRGQKLGHIDH- 311
+L S R + +RR+ +K E+ +ER+ ++ + E R Q+L +
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691
Query: 312 ----------PVMVVNVDNSVTAKVRKVATAP-PAPAYKGFNPSETKIRTPDGKV-WQEA 359
P +++ A+ KV + P + E K R + ++ WQE
Sbjct: 692 QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE 751
Query: 360 EF---QNMSRELYRDLALHFADDISIKEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTG 416
E Q E RD + E+ +E+ +++ +P + Q+ QL + E +
Sbjct: 752 ERAHRQQQEEEQRRDFTWQWQ-----AEEKSERGRQRLSARPPLREQRERQLRAEERQQR 806
Query: 417 SSHLISTSSWRDGQKLVKK------------------------------ILGPAPRMEPK 446
+ ++ ++ ++ + R +
Sbjct: 807 EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQ 866
Query: 447 EQRTASSDRGGRERTAKSGGHIGRAESDPRL-DVLHRHLQRNSERSRSKSRSENNIKKLA 505
EQR R E K H A+ P L + L + Q E R E ++
Sbjct: 867 EQRRDQKWRWQLEEERKRRRHTLYAK--PALQEQLRKEQQLLQEEEEELQREEREKRRRQ 924
Query: 506 SSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVELQNQKSSAPVHAPRS 565
++EE ++ L E R + + K+ + + P R
Sbjct: 925 EQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQ 984
Query: 566 HSPVKRKPDKITANEDPPVISK-----------RRHYDTDEVRQ---YIVRQQEERKRKQ 611
K + ++ E+ ++ + R++ DE++Q ++R++ E++R Q
Sbjct: 985 EREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQ 1044
Query: 612 NEEKKAQKE-----------ATEQKNKRLQEL---YRKQKEAFTKVKNVPPSEPSATRRL 657
E++ ++E E++ +R QEL YRK++E + + + EP RR
Sbjct: 1045 ERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQ 1104
Query: 658 QETYSKLLLEKTLLEEPSHQHVTQETQAKPGYQPSGESDKENKVQERPPSASSSSDMSLS 717
+ + E+ L++ Q + +E + + + + +E +VQ+ + L
Sbjct: 1105 ER--ERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ-------EEEQLLR 1155
Query: 718 EPPQPLARKDLMESTWMQPERLSPQ 742
E P+ R++L E + + E L +
Sbjct: 1156 EEPEKRRRQEL-ERQYREEEELQQE 1179
Score = 43.9 bits (102), Expect = 0.002
Identities = 73/398 (18%), Positives = 164/398 (41%), Gaps = 25/398 (6%)
Query: 362 QNMSRELYRDLALHFADDISIKEKPAEKSKEKKV--VKPVRKVQKVAQLSSTECRTGSSH 419
Q + R+ ++ L ++ ++E+P ++ ++++ + ++Q+ + E R
Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR 1133
Query: 420 LISTSSWRDGQKLVKKILGPAPRMEPKEQRTASSDRGGRERTA--KSGGHIGRAESDPRL 477
+R+ ++ V++ R EP+++R +R RE + + R E + R
Sbjct: 1134 QELERQYREEEE-VQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192
Query: 478 DVLHRHLQRNSERSRSKSRSENNIKKLASSLPDN-KQEENTALNKDFLPIEIRGILDDLQ 536
R + E R K + + S L + E+ A+ + + + R Q
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQ 1252
Query: 537 LDSTAHTAKQDTVELQN-----QKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHY 591
L+ + +Q +LQ+ Q+ R + P++ + +KRR
Sbjct: 1253 LEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDR 1312
Query: 592 DTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEP 651
+ E +Q + ++EE++R+Q ++K ++E + + Q L R++++ + + +
Sbjct: 1313 KSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEEL----- 1367
Query: 652 SATRRLQETYSKLLLEKTLL--EEPSHQHVTQETQAK-PGYQPSGESDKENKVQERPPSA 708
R QE K L E+ L +E + + +E Q + + D++ K +E
Sbjct: 1368 ----RHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL 1423
Query: 709 S-SSSDMSLSEPPQPLARKDLMESTWMQPERLSPQVHH 745
S D E Q + R++ E +++ E+ Q H
Sbjct: 1424 SRQERDRKFREEEQQVRRQE-RERKFLEEEQQLRQERH 1460
Score = 41.6 bits (96), Expect = 0.012
Identities = 59/286 (20%), Positives = 120/286 (41%), Gaps = 31/286 (10%)
Query: 442 RMEPKEQRTASSDRGGRE----RTAKSGGHIGRAESDPRLDVLHRHLQRNSERSRSKSRS 497
R E +QR DR RE R + + R E D + + + ++R E+ R
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ-EQERKFMED 1600
Query: 498 ENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAK--QDTVELQNQK 555
E +++ +QE + +D ++ R ++ QL K ++ +L+ Q+
Sbjct: 1601 EQQLRRQEGQ-QQLRQERDRKFREDEQLLQER---EEQQLHRQERDRKFLEEEPQLRRQE 1656
Query: 556 SSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNEEK 615
+ R K + ++ E +R+ D R++ R++E++ R+Q E+
Sbjct: 1657 REQQLRHDRDR---KFREEEQLLQEGEEQQLRRQERD----RKF--REEEQQLRRQERER 1707
Query: 616 KAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKTLLEEPS 675
K +E + + + L+ +R++++ + +E RR QE Y K+L E+ L E
Sbjct: 1708 KFLQEEQQLRRQELERKFREEEQLRQE------TEQEQLRR-QERYRKILEEEQLRPERE 1760
Query: 676 HQHVTQETQAKPGYQPSGESDKENKVQERPPSASSSSDMSLSEPPQ 721
Q + ++ + + E ++ + +E S SD E Q
Sbjct: 1761 EQQLRRQERDR----KFREEEQLRQEREEQQLRSQESDRKFREEEQ 1802
Score = 41.2 bits (95), Expect = 0.016
Identities = 60/351 (17%), Positives = 137/351 (39%), Gaps = 18/351 (5%)
Query: 356 WQEAEFQNMSRELYRDLALHFADDISIKEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRT 415
WQE E + E + H ++ +E+ + +++++ RK ++ Q E +
Sbjct: 180 WQEREERRAEEEQLQSCKGHETEEFPDEEQ----LRRRELLELRRKGREEKQQQRRERQD 235
Query: 416 GSSHLISTSSWRDGQKLVKKILGPAPRMEPKEQRTASSDRGGRERTAKSGGHIGRAESDP 475
WR + +++K EP+ QR + + + R E +
Sbjct: 236 RVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQ 295
Query: 476 RLDVLHRH--LQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILD 533
+ L R L+R E R + + E ++ + ++E+ L ++ + +
Sbjct: 296 QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ--LRREQEERREQQLRR 353
Query: 534 DLQLDSTAHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDT 593
+ + + +++ E + ++ R ++R+ + RR
Sbjct: 354 EQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 413
Query: 594 DEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSA 653
+Q +R++++ +R+Q EE+ QK E++ +RL+ R+Q+E +K
Sbjct: 414 RREQQ--LRREQQLRREQEEERHEQKHEQERREQRLK---REQEERRDWLK-----REEE 463
Query: 654 TRRLQETYSKLLLEKTLLEEPSHQHVTQETQAKPGYQPSGESDKENKVQER 704
T R ++ K L++ EE + + E + + Q E + +ER
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER 514
Score = 40.4 bits (93), Expect = 0.028
Identities = 31/137 (22%), Positives = 66/137 (48%), Gaps = 4/137 (2%)
Query: 2695 EKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQL---EAQLKSSLNEEKKSKQQLEKI 2751
EKQQQ E +D ++ E EK +L +E+ +L E Q + L EE++ ++LE+
Sbjct: 225 EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ 284
Query: 2752 SLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKVTPQD-LSQNVEEQSP 2810
L + + + + + QQ+++ ++E+ + +E +++ ++ Q + +
Sbjct: 285 ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE 344
Query: 2811 SISGCFLSSELEDEKEE 2827
L E E+E+ E
Sbjct: 345 ERREQQLRREQEEERRE 361
Score = 38.5 bits (88), Expect = 0.10
Identities = 69/427 (16%), Positives = 161/427 (37%), Gaps = 63/427 (14%)
Query: 357 QEAEFQNMSRELYRDLALHFADDISIKEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTG 416
Q+ + R ++ HF + E+ E+ ++K+ + RK Q+ QL E
Sbjct: 1274 QQERDREQERRRWQQRDRHFPE-----EEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328
Query: 417 SSHLISTSSWRDGQKLVKKILGPAPRMEPKEQRTASSDRGGRERTAK---SGGHIGRAE- 472
+ +R+ ++L+++ R + ++++ + +E+ K + R E
Sbjct: 1329 RRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQER 1388
Query: 473 ------SDPRLDVLHRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPI 526
+ +L R Q +R R E + + ++E+ +
Sbjct: 1389 ERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQER---- 1444
Query: 527 EIRGILDDLQLDSTAHTAKQDTVELQNQKSSAPVHAP----------------------R 564
E + + ++ QL H ++ +L ++ +H R
Sbjct: 1445 ERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFR 1504
Query: 565 SHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQ 624
++P++ E+ + ++R + Q + RQ+ ++R+Q+ ++K ++E +
Sbjct: 1505 EQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLR 1564
Query: 625 KNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKTLLEEPSHQHVTQETQ 684
+ + Q+L R++++ ++ E RR ++ + E+ L + Q + QE
Sbjct: 1565 QEREEQQLSRQERDRKFRL------EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD 1618
Query: 685 AKPGYQPSGESDKENKVQERPPSASSSSDMSLSEPPQPLARKDLMESTWMQPERLSPQVH 744
K + E +QER + L Q RK L E ++ + Q+
Sbjct: 1619 RK-------FREDEQLLQER-------EEQQLHR--QERDRKFLEEEPQLRRQEREQQLR 1662
Query: 745 HSQPQPF 751
H + + F
Sbjct: 1663 HDRDRKF 1669
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 84.0 bits (206), Expect = 2e-15
Identities = 345/1736 (19%), Positives = 684/1736 (39%), Gaps = 300/1736 (17%)
Query: 1330 AAELSYLNAIEESVRQLSD--------VERVRGISLAQQESVSLAQIIKAQQQRHERDLA 1381
A E+S LN + E ++ +D + R L+Q + +S+ ++AQ ++ E +LA
Sbjct: 715 AKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLA 774
Query: 1382 LLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSET 1441
+ Q L+ + Q Q+H+ S++ +S+ EVLQ + Q SE
Sbjct: 775 EAE---RQRRLDYESQTAHDNLLTEQIHSLSIE--AKSKDVKIEVLQNELDDVQLQFSEQ 829
Query: 1442 ARLTTDAARQ-------ICEMAELTRTHISDAVVASGAPLA-----------ILYDHQRQ 1483
+ L Q + E AE R HIS V L+ +L + +R
Sbjct: 830 STLIRSLQSQLQNKESEVLEGAERVR-HISSKVEELSQALSQKELEITKMDQLLLEKKR- 887
Query: 1484 HLPDFVKQLRTRTETDRKSPSVSLSQSKE---------------GTLDSKHQKYSASYDS 1528
D +T E D++ +S S +++ TL + S + ++
Sbjct: 888 ---DVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEA 944
Query: 1529 YSE--------SSGYK-NHDRRSSSGS-SRQESPSVPSCKENEKKLNGEKIESSIDEQVQ 1578
E SSG K N+D S +G S++E + E + K+++++ + +
Sbjct: 945 KKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKE 1004
Query: 1579 TAADDSLRSDSVPSLPDE-KDSTSIATEYSLKFDESMTEDEIEEQSFRS--------LLP 1629
S + + +L DE K ++ + +E E E+ S L
Sbjct: 1005 LLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQ 1064
Query: 1630 SESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEM-----V 1684
+ S + ++ R D +E+ + E+ + K++N + E+ +
Sbjct: 1065 TISEKEVELQHIR---KDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAI 1121
Query: 1685 RQYMKEEEMRAAHQSSLLRLREKAL------------KEKTKAELAWLEHQKKHLRDKGE 1732
Q + A+ S+ ++E + K + + ++ LE +K+ L+ K +
Sbjct: 1122 IQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQ 1181
Query: 1733 DDK------MPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQ 1786
+ + ++K+R L L+Q+K + RLQE KE + I Q +RQ
Sbjct: 1182 EALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQ------LRQ 1235
Query: 1787 TTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKL 1846
I+++E + + KL S D +++ +++PG P + T +++
Sbjct: 1236 LQIQVRESI----DGKLPS---TDQQESCSSTPG-----LEEPLFKATEQHHTQPVLE-- 1281
Query: 1847 KKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIK 1906
S + + + E Q + + K +L EAE ++E + +++ EL K
Sbjct: 1282 ----SNLCPDWPSHSED--ASALQGGTSVAQIKAQLKEIEAEKVELELK-VSSTTSELTK 1334
Query: 1907 PKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQP 1966
+L++Q +Q + E V + +++E S+ ++L S ++ E + + QP
Sbjct: 1335 KSEEVFQLQEQINKQ-GLEIESLKTVSHEAEVHAE-SLQQKLESSQLQIAGLEHLRELQP 1392
Query: 1967 GSPD-HSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSH 2025
+ +++++ L S + +L K T + +QE + T Q + K H
Sbjct: 1393 KLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHT--QLEMQAKEH 1450
Query: 2026 QHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKA 2085
+ RI+ L+ EL + K ++ +E + +Q+ + K
Sbjct: 1451 -------------------------DERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL 1485
Query: 2086 QEASLIKQLESYDEFIKKTEAELS---QDLETSPTAKPQIKTLSSASEKPKIKPLTPLHR 2142
Q A+LI + E+ E K + ELS +E + +++ SA K K L L
Sbjct: 1486 Q-AALISRKEALKE-NKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLAL 1543
Query: 2143 SETAKNWKSLTESERS---RGSLESIAEHVDASLSG----SERSVSE-RSL-SAYAKRVN 2193
+ ++ K +TE +RS SL S E + +L G E+ V E SL S+
Sbjct: 1544 LQEERD-KLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAEST 1602
Query: 2194 EWDSRTEDFQTPSPVLRSSRKIREESGDSLENV------PALHLLKELNATSRILDMSDG 2247
EW + ++ Q +L S + + +++V L +L +T ++
Sbjct: 1603 EWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEK 1662
Query: 2248 KVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGD----------SSEI 2297
++ E+ ++ E + + K KSK + E ++D L V GD SS
Sbjct: 1663 QLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNA 1722
Query: 2298 LSKKDL---PLDSENVQKDLVGLAIENLHKSEEMLK-ERQSDQDMNHSPNIQSGKDIHEQ 2353
K++L ++ E + K L E SEE+ + Q + +++ N+++ + Q
Sbjct: 1723 SMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQ 1782
Query: 2354 KN------------TKEKD-LSWSEHLFAPKEIP--------YSEDFEVSSFKKEISAEL 2392
N T+E+D LS S + +P S+DF S EI+ L
Sbjct: 1783 TNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDF---SSHDEINNYL 1839
Query: 2393 YKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEISECLSEKSLSIHSNVHS 2452
+ D + L ++ Q ++ Q + + + S S ++ + ++ ++ + ++
Sbjct: 1840 QQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQ 1899
Query: 2453 DRLLELKSPTELMKSKERSDVEHEQQVTESPSLASVPTADELFDFHIGDRVLIGNVQPGI 2512
EL T+L ++ E + E+++ LA + + IGN +
Sbjct: 1900 QIQEELSRVTKLKETAEEEKDDLEERLMN--QLAELNGS-------------IGNYCQDV 1944
Query: 2513 LRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKI-SHIPENFD 2571
A ++ + E ++ E +EK + K+ S I + +
Sbjct: 1945 TD------------AQIKNELLESEMKNLKKCVSELE-EEKQQLVKEKTKVESEIRKEYL 1991
Query: 2572 DYVDINEDE---DCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYEKSLPSVNDIEASVN 2628
+ + + E ++ E + ++Q + K +KD Y EK ++ +E +V
Sbjct: 1992 EKIQGAQKEPGNKSHAKELQELLKEKQQEV---KQLQKDCIRY-QEK----ISALERTVK 2043
Query: 2629 RSRSLKIETDNVQDIS--GVLEAHVHQQSSVDSQISSKENKDLISDA-TEKVSIAAEDDT 2685
++ E+ +I+ + +A H++ +Q K L+ D +E + A++
Sbjct: 2044 ALEFVQTESQKDLEITKENLAQAVEHRKK---AQAELASFKVLLDDTQSEAARVLADNLK 2100
Query: 2686 LDNTF---SEELEKQQQFTEEEDNLYAEASE-------KLCTPLLDLLTREKNQLE---A 2732
L E ++ Q + +E+ E +E K LD L REK LE
Sbjct: 2101 LKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIG 2160
Query: 2733 QLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKD----------TVNQLQQIKKTRDEKIQ 2782
+++ +LN++ K QQL++ T + L F K +++ ++ ++ + IQ
Sbjct: 2161 EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ 2220
Query: 2783 LSNQEL-LGDDQKKVTPQDLSQ---NVEEQSPSISGCFLSSELEDEKEEIS---SPDMCP 2835
+E+ L +D V L Q ++EE +IS ++ + K + +C
Sbjct: 2221 SKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD 2280
Query: 2836 R------------PESPVFGASGQEELAKRLAELELSREFLSALGDDQDWFDEDFG 2879
E+ S Q ELAK +EL+ ++ L+ L + + E G
Sbjct: 2281 TLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKG 2336
Score = 83.6 bits (205), Expect = 3e-15
Identities = 319/1698 (18%), Positives = 638/1698 (37%), Gaps = 206/1698 (12%)
Query: 1491 QLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYS----ESSGYKNHDRRSSSGS 1546
Q++ R D K PS +S T + + A+ ++ ES+ + S S
Sbjct: 1237 QIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDAS 1296
Query: 1547 SRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEY 1606
+ Q SV K K++ EK+E + T ++ + +S+ V L ++ + + E
Sbjct: 1297 ALQGGTSVAQIKAQLKEIEAEKVELELKVS-STTSELTKKSEEVFQLQEQINKQGLEIE- 1354
Query: 1607 SLKFDESMTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELN 1666
SLK E E+ +S + L S + +E R DE L + KE +
Sbjct: 1355 SLKTVSH--EAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQK-----LISKKEED 1407
Query: 1667 MPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKH 1726
+ + GQ S + + ++ + E+E + L ++ K E+ K L K+
Sbjct: 1408 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQK 1467
Query: 1727 LRDKGEDDKMPP-LRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIR 1785
+ GE+ + +++K + L+ ++ E K LQE AR + + K ++E
Sbjct: 1468 PEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVE--- 1524
Query: 1786 QTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQK 1845
+ + Q K K +L ++ +D T + LE +S +S S ++
Sbjct: 1525 -SQVSAQNKEKDTVLGRLALLQEE--RDKLITEMDRSLLENQS---LSSSCESLKLALEG 1578
Query: 1846 LKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLD---------AEEAEIRQMEKQA 1896
L + + ++ ++ + + K+ + + E+ E ++ + + EAE Q +A
Sbjct: 1579 LTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEA 1638
Query: 1897 LAAWDKELI----KPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSES--SIPEELGS 1950
+ +EL + KKE E Q E ++ E + + ++ + + EE
Sbjct: 1639 VRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDR 1698
Query: 1951 PAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKG 2010
E P+ +E C + L SS + K L + K E
Sbjct: 1699 LRAEVHPAGDTAKE---------------CMETLLSSNASMKEELERV-----KMEY--- 1735
Query: 2011 SHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQ 2070
E+LS S++ + ++ LK ++ S
Sbjct: 1736 -----------------------ETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQAN 1772
Query: 2071 LKKEQKKRQKERLKAQEASLIK-QLESYDEFIKKTEAELSQDLETSPTAKPQI-KTLSSA 2128
L+ +K + + + I + E D T S+ + ++ +A P + K SS
Sbjct: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSH 1832
Query: 2129 SEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAY 2188
E L + + K + E E+ + S + + S+ S + L
Sbjct: 1833 DEINNY-----LQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKML 1887
Query: 2189 AKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNAT--SRILDMSD 2246
+ V + + + Q + ++ EE D LE ++ L ELN + + D++D
Sbjct: 1888 QEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEE-RLMNQLAELNGSIGNYCQDVTD 1946
Query: 2247 GKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSKKDLPLD 2306
++ K+E+ E E LKK E +E + V K +E E L K
Sbjct: 1947 AQI-----KNELLESEMKNLKKCVSE--LEEEKQQLVKEKTKVESEIRKEYLEK------ 1993
Query: 2307 SENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNT---------- 2356
+ QK+ + + + +E+LKE+Q + I+ + I + T
Sbjct: 1994 IQGAQKEPGNKS--HAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTE 2051
Query: 2357 KEKDLSWS-EHLFAPKEIPYSEDFEVSSFK------KEISAELYKDDFEVSSLLSLRKDS 2409
+KDL + E+L E E++SFK + +A + D+ ++ L K+S
Sbjct: 2052 SQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKES 2111
Query: 2410 ------QSCRDKPQPMRSSTSGATSFGSN-EEISECLSEKSLSIHSNVHSDRLLELKSPT 2462
Q D + + + N +E + L + + + + ++ K
Sbjct: 2112 VKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDK 2171
Query: 2463 ELMKSKERSDVEHEQQVTESPSLASVP-----TADELFDFHIGDRVLIGNVQPGILRFKG 2517
E+ + +E D Q + S++S+ DE + I + + I +
Sbjct: 2172 EVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKED 2231
Query: 2518 ETSFAKGFWA--GVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIP-ENFDDYV 2574
S K + +++ + N + +E K + + + + EN +
Sbjct: 2232 NCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLS 2291
Query: 2575 DINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYEKSLPSVNDIEASVNRSRS-L 2633
+ E Y + + E ++ + KD+ D+S EK ++E + + + +
Sbjct: 2292 QLEETRHLYHSSQNELAKLE-SELKSLKDQLTDLSNSL-EKCKEQKGNLEGIIRQQEADI 2349
Query: 2634 KIETDNVQDISGVLEAHVHQQSSVDSQISSKENK--DLISDATEKVSIAA---------E 2682
+ + + + L+A S + +I+ KE K L+S E + +A E
Sbjct: 2350 QNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKE 2409
Query: 2683 DDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQLEAQL------KS 2736
L+N S+E +++ EE+N A L + +E Q +AQL S
Sbjct: 2410 IKELENLLSQE--EEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMS 2467
Query: 2737 SLNEEKK----SKQQLEK----ISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQEL 2788
SL ++ QQLE+ I L D L++ + ++I+ R L+++
Sbjct: 2468 SLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENA 2527
Query: 2789 LGDDQKKVTPQDLSQNV---EEQSPSISGCFL--SSELEDE----KEEISSPDMCPRPES 2839
D + +DL+Q + + Q + L + ELE++ +E++ +
Sbjct: 2528 KLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLR 2587
Query: 2840 PVFGASGQE--ELAKRLAELELSREFLSALGDDQDWFDEDFGLSSSH---KIQKNKAEET 2894
F A +E +L+K + L++S +S L E+ L H K+++ +
Sbjct: 2588 RSFNALQEEKQDLSKEIESLKVS---ISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRL 2644
Query: 2895 IVPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKELGHDLHSISIPTKLL 2954
+ KR+ + E + A++V + +EL K L HD + T
Sbjct: 2645 SALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKEL---KHLHHDAGIMRNET--- 2698
Query: 2955 GCASKGLDIESTSKRVYKQA--VFDLTKEIFEEIFAEDPNLNQPVWMKPCRINSSYFRRV 3012
E+ +RV + A + ++ +++ + E+ L + ++S R
Sbjct: 2699 ---------ETAEERVAELARDLVEMEQKLL-MVTKENKGLTAQIQSFGRSMSSLQNSRD 2748
Query: 3013 KNPNNLDEIKSFIASEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVDHILVQELHEEEA 3072
LDE+K + + +L LK++ + ++ + + + L +
Sbjct: 2749 HANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQ 2808
Query: 3073 QWVNYDEDELCVKMQLAD 3090
Q ++ DE L + QL D
Sbjct: 2809 QLLSKDEQLLHLSSQLED 2826
Score = 80.9 bits (198), Expect = 2e-14
Identities = 260/1256 (20%), Positives = 495/1256 (39%), Gaps = 211/1256 (16%)
Query: 1614 MTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQ 1673
++ D+ +Q+ R+ L E H+ +ME +D E L+ A++L +
Sbjct: 16 LSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQER-------LAYAEQLVVELK--- 65
Query: 1674 DSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGED 1733
+++RQ + L+ +++AL+E+ KA ++ K H + K
Sbjct: 66 --------DIIRQ-----------KDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTS 106
Query: 1734 -DKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQ 1792
+K K Q G +L + + E +L + +K++ +E + EIEKI+ KLQ
Sbjct: 107 LNKYIEEMKAQGGTVLPTEPQSEE--QLSKHDKSSTEE-------EMEIEKIKH---KLQ 154
Query: 1793 EK--LKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMR 1850
EK L S +++L T + P+ S E + Q+L++
Sbjct: 155 EKEELISTLQAQL------------------TQAQAEQPAQSSTEMEEFVMMKQQLQE-- 194
Query: 1851 SRMDEKFLTKREQKLMQRR--QHAEELLEWKRRLDAE-EAEIRQMEKQALAAWDKELIKP 1907
E+F++ + +L Q + Q A++++ R DA E ++R E + L +L+
Sbjct: 195 ---KEEFISTLQAQLSQTQAEQAAQQVV---REKDARFETQVRLHEDELL-----QLVTQ 243
Query: 1908 KTPKKELEDQ-RTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQP 1966
+ E++ + R Q+++ EES L + +EL A E Q Q
Sbjct: 244 ADVETEMQQKLRVLQRKLEEHEES---LVGRAQVVDLLQQEL--TAAEQRNQILSQQLQQ 298
Query: 1967 GSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSH------RTGGQCHL 2020
+H+ L + +E ES K L + +S + H GQ
Sbjct: 299 MEAEHNTLRNTVETERE-ESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQA 357
Query: 2021 PIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKK--R 2078
++S YS ++ E TS I +L+ ++ +S + LK + K +
Sbjct: 358 ELESR---YSALEQKHKAEMEEKTS-------HILSLQKTGQELQSACDALKDQNSKLLQ 407
Query: 2079 QKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLT 2138
K Q A I+QLE D+ +K++ E+SQ L P Q +T S S T
Sbjct: 408 DKNEQAVQSAQTIQQLE--DQLQQKSK-EISQFLNRLPL--QQHETASQTSFPDVYNEGT 462
Query: 2139 PLHRSET-AKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDS 2197
E A K + E E +G+L + ++ + +E+ S+ +L R E D
Sbjct: 463 QAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADR 522
Query: 2198 RTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDG-------KVG 2250
+ + S E D LEN + KEL+ +L+M + K+
Sbjct: 523 EVSEISIVDIANKRSSSAEESGQDVLENTFS-QKHKELSVL--LLEMKEAQEEIAFLKLQ 579
Query: 2251 ESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSKKDLPLDSENV 2310
K++E + E K+ K EG + + +K+ LE + +D PL N
Sbjct: 580 LQGKRAEEADHEVLDQKEMK---QMEGEGIAPIKMKVFLED-------TGQDFPL-MPNE 628
Query: 2311 QKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAP 2370
+ L A+E S E + +N +G ++ K +K LS A
Sbjct: 629 ESSLP--AVEKEQASTEHQSRTSEEISLN-----DAGVELKSTKQDGDKSLS------AV 675
Query: 2371 KEIPYSEDFEVSSFKKEI---------SAELYKDDF-----EVSSLLSLRKDSQSCRDKP 2416
+I E+ K +I + E+Y+ + E+S+L L ++ + D
Sbjct: 676 PDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNAD-- 733
Query: 2417 QPMRSSTSGATSFGSNEEISECLSE-KSLSIHSNVHSDRLLELKSPTELMKSKERSDVE- 2474
+++S T+ +EE + LS+ K LS+ + + + ++ +L+ + + R D E
Sbjct: 734 ----NNSSAFTAL--SEERDQLLSQVKELSMVTELRA-QVKQLEMNLAEAERQRRLDYES 786
Query: 2475 ---HEQQVTESPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVEL 2531
H+ +TE S+ + + VL + L+F +++ + + ++
Sbjct: 787 QTAHDNLLTEQIHSLSIEAKSK----DVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQN 842
Query: 2532 DKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCY 2591
+ E + +++ HI ++ ++ + Q
Sbjct: 843 KESE--------------------VLEGAERVRHISSKVEELSQALSQKELEITKMDQLL 882
Query: 2592 NQEQNDTE----GPKDREKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNVQDISGVL 2647
+++ D E +++++ V+E + + V E + +K + + +S
Sbjct: 883 LEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAE 942
Query: 2648 EAHVHQQSSVDSQISS--KENKDLISDATE--KVSIAAEDDTLDNTFSEELEKQQQFTEE 2703
EA +Q D+++SS K+N D +S A + K + E D L + K Q
Sbjct: 943 EAK-KEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALIN 1001
Query: 2704 EDNLYAEASEKLCTPLLDLLTREKNQ--LEAQLKSSLNEEKKSKQQLEKISLLTDSLLKV 2761
L S +L L +L K + L + + E+K++K+ EK +++
Sbjct: 1002 RKELLQRVS-RLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEI 1060
Query: 2762 FVKDTVN----QLQQIKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNVEEQSPSIS 2813
++K T++ +LQ I+K +EK+ Q Q T QD + ++ IS
Sbjct: 1061 YLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1116
Score = 77.8 bits (190), Expect = 2e-13
Identities = 216/1088 (19%), Positives = 441/1088 (40%), Gaps = 130/1088 (11%)
Query: 1340 EESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALESQRQLE 1399
E+ + + ++E ++ +A ES + K Q+ +E L + EA Q +E
Sbjct: 1581 EDKEKLVKEIESLKSSKIA--ESTEWQEKHKELQKEYEILLQSYE-NVSNEAERIQHVVE 1637
Query: 1400 ETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELT 1459
R + +++ + L+ +++E + LQEA ++ + + + ++I E+ E
Sbjct: 1638 AVRQEKQELYGK-LRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEE- 1695
Query: 1460 RTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEG--TLDS 1517
+D + A P D K+ + S L + K TL
Sbjct: 1696 ----NDRLRAEVHPAG-----------DTAKECMETLLSSNASMKEELERVKMEYETLSK 1740
Query: 1518 KHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQV 1577
K Q + DS SE H + S+Q + +N+ + E +S E
Sbjct: 1741 KFQSLMSEKDSLSEEVQDLKH--QIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGE-- 1796
Query: 1578 QTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRFN 1637
T DSL + P+ + S A K + + DEI ++ + R
Sbjct: 1797 -TEEQDSLSMSTRPTCSESVPSAKSANPAVSK--DFSSHDEIN--NYLQQIDQLKERIAG 1851
Query: 1638 MEKRRGHHDDSDEEASPEKTTL-STAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAA 1696
+E+ + + + + EK TL S + Q+ +K M ++ Q ++EE R
Sbjct: 1852 LEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTK--MNLLNQQIQEELSRVT 1909
Query: 1697 HQSSLLRLREKALKEKTKAELA---------------------WLEHQKKHLR---DKGE 1732
+ L+E+ +LA LE + K+L+ + E
Sbjct: 1910 KLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELE 1969
Query: 1733 DDKMPPLRKKQR--GLLLRLQQEKAEIKRLQEANKAARKERQLILK-QQEEIEKIRQTTI 1789
++K +++K + + + EK + + + NK+ KE Q +LK +Q+E++++++ I
Sbjct: 1970 EEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCI 2029
Query: 1790 KLQEKLKSAGES-------KLDSHSD-DDTKDNKATSPGPTDLETRSPSPISISSSETSS 1841
+ QEK+ + + + +S D + TK+N A + + + +T S
Sbjct: 2030 RYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQS 2089
Query: 1842 IMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLD-AEEAEIRQME--KQALA 1898
++ ++ ++ + +E Q +Q E+L +RRL+ AEE +++ + ++ L
Sbjct: 2090 EAARVLADNLKLKKELQSNKESVKSQMKQKDEDL---ERRLEQAEEKHLKEKKNMQEKLD 2146
Query: 1899 AWDKELIKPKTPKKELE-DQRTEQKEIASEEE----SPVPLYSHLNSESSIPEELGSPAV 1953
A +E + + E++ + KE+ +E + L + S SS+ ++
Sbjct: 2147 ALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVID 2206
Query: 1954 EYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHR 2013
E E + S + I +E CS + S H + + ++S+ E K
Sbjct: 2207 EAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIH-MEELKINISRLEHDKQIWE 2265
Query: 2014 TGGQCHLPIKSHQHCYSWSDESLSMTQSETT--------SDQSDIEGRIRALKDELRKRK 2065
+ Q + ++ + ++Q E T ++ + +E +++LKD+L
Sbjct: 2266 SKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLS 2325
Query: 2066 SVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEA--ELSQDLETSPTAKPQ-I 2122
+ + + KEQK + ++ QEA + SY++ +A EL+ L K Q I
Sbjct: 2326 NSLEKC-KEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKI 2384
Query: 2123 KTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSE 2182
+L S E+ + L R + K K L E+ S+ E+I + + + +
Sbjct: 2385 ISLLSGKEEAIQVAIAEL-RQQHDKEIKEL-ENLLSQEEEENIVLEEENKKAVDKTNQLM 2442
Query: 2183 RSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRIL 2242
+L K + ++ + F L++ R+ + + HL L I
Sbjct: 2443 ETLKTIKKENIQQKAQLDSFVKSMSSLQND---RDRIVGDYQQLEERHLSIILEKDQLIQ 2499
Query: 2243 DMSDGKVGESSK-KSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSKK 2301
+ + E++K K EI+ + +S ++D S+ K D +L+ + D +++++ K
Sbjct: 2500 EAA----AENNKLKEEIRGL------RSHMDDLNSENAKLDA--ELIQYREDLNQVITIK 2547
Query: 2302 DLPLDSENVQKDLVGL------AIENLH-KSEEMLKE-RQSDQDMNHSPNIQSGKDIHEQ 2353
D + QK L+ + +EN + K EE LKE ++++D+ S N + E+
Sbjct: 2548 D------SQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNA-----LQEE 2596
Query: 2354 KNTKEKDL 2361
K K++
Sbjct: 2597 KQDLSKEI 2604
Score = 77.0 bits (188), Expect = 3e-13
Identities = 338/1893 (17%), Positives = 714/1893 (37%), Gaps = 230/1893 (12%)
Query: 1360 QESVSLAQIIKAQQQRHERD-------LALLKLKAEQEALESQRQLEETRNKAAQVHAES 1412
Q S + + + +QQ E++ L + +AEQ A + R+ + ++H +
Sbjct: 177 QSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDE 236
Query: 1413 LQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEM--AELTRTHISDAVVAS 1470
L Q+V TE+ Q+ ++ ++ E + Q+ ++ ELT + +++
Sbjct: 237 LLQLVTQADVETEMQQK--LRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILS- 293
Query: 1471 GAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYS 1530
Q Q + LR ET+R+ + L + + + K ++ + +
Sbjct: 294 ---------QQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHH 344
Query: 1531 ESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSV 1590
++ + + SR + E E+K + +++Q+A D+L+ +
Sbjct: 345 LLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSAC-DALKDQNS 403
Query: 1591 PSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDE 1650
L D+ + + + + ++ + + E F + LP + H + +++ +
Sbjct: 404 KLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQ 463
Query: 1651 EASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREK--- 1707
+ E + + + G S +E +K E + + Q +LL + +
Sbjct: 464 AVTEENIASLQKRVVELENEKGALLLSSIELE----ELKAENEKLSSQITLLEAQNRTGE 519
Query: 1708 ALKEKTKAELAWLEHQK-KHLRDKGED---DKMPPLRKKQRGLLLRLQQEKAEIK--RLQ 1761
A +E ++ + + +++ + G+D + K+ LLL +++ + EI +LQ
Sbjct: 520 ADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQ 579
Query: 1762 EANKAARKERQLILKQQE--EIEKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSP 1819
K A + +L Q+E ++E IK++ L+ G+ +++ +
Sbjct: 580 LQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQ 639
Query: 1820 GPTDLETRSPSPISISSS--ETSSIMQKLKKMRS--------RMDEKFLTKREQKLMQRR 1869
T+ ++R+ IS++ + E S Q K S DE K + ++
Sbjct: 640 ASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELN 699
Query: 1870 QH-AEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEE 1928
H A+E+ E + LD + EI + Q + + K + L ++R + E
Sbjct: 700 FHKAQEIYE--KNLDEKAKEISNL-NQLIEEFKKNADNNSSAFTALSEERDQLLSQVKEL 756
Query: 1929 ESPVPLYSHLNS-ESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESS 1987
L + + E ++ E ++Y + H L E I S +E+
Sbjct: 757 SMVTELRAQVKQLEMNLAEAERQRRLDYESQTA----------HDNLLTEQIHSLSIEAK 806
Query: 1988 TSPSK-HSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ---------HCYSWSDE-SL 2036
+ K L V Q S + + Q L K + H S +E S
Sbjct: 807 SKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQ 866
Query: 2037 SMTQSE---TTSDQSDIEGR--IRALKDELRKRKSVVNQL------KKEQKKRQKERLKA 2085
+++Q E T DQ +E + + L+ + ++ V ++ K Q +K L
Sbjct: 867 ALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGV 926
Query: 2086 QEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASE--KPKIKPLTPLHRS 2143
+ +L +QL + + ++ +D E S K +S A + K +++ L +
Sbjct: 927 EIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKK 986
Query: 2144 ETAKNWKSLTESERSRGSLESIAEHVDASLSG-SERSVSERSLSAYAKRVNEWDSRTEDF 2202
E + + L + +R L ++ L+ + S E LS + E D +++
Sbjct: 987 ENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEY 1046
Query: 2203 QTPSPVLRSSR-KIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEI 2261
+ +I + S + V H+ K D+ + E ++ +K++
Sbjct: 1047 SEKCVTSKCQEIEIYLKQTISEKEVELQHIRK---------DLEEKLAAEEQFQALVKQM 1097
Query: 2262 EYTKLKKSKIEDAFSKEGKSD--VLLKLVLEQGDSSE----------------------- 2296
T K+ D E + ++ KL+ D+S+
Sbjct: 1098 NQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEH 1157
Query: 2297 ---ILSKKDLPLDSENVQ------------KDLVGLAIENLHKSEEMLKERQSDQDMNHS 2341
L +K L L+ E Q K ++ A E E LK+++ D +
Sbjct: 1158 WKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQE 1217
Query: 2342 PNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYK--DDFEV 2399
+ K+ +E + + L ++P ++ E S + L+K +
Sbjct: 1218 QFDEQSKE-NENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHT 1276
Query: 2400 SSLLSLRKDSQSCRDKPQPMR--SSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLE 2457
+L +S C D P S+ G TS + + + + + + V S
Sbjct: 1277 QPVL----ESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSEL 1332
Query: 2458 LKSPTELMKSKERSDVEHEQQVTESPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKG 2517
K E+ + +E+ + +Q E SL +V E+ + ++ +Q L
Sbjct: 1333 TKKSEEVFQLQEQIN----KQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLR 1388
Query: 2518 ETSFAKGFWAGVELDKPEGNNNGTYDGIAYF--ECKEKHGIFAPPQKISHIPENFDDYVD 2575
E +LD+ + + + ++Y + EK Q + I E D
Sbjct: 1389 ELQ--------PKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQ--TEIIEQEDLIKA 1438
Query: 2576 INEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYEKSLPSVNDIEASVNRSRSLKI 2635
++ + + E + Q Q + K + +++ E K A ++R +LK
Sbjct: 1439 LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKE 1498
Query: 2636 ETDNVQDIS---GVLEAHVHQQSSVDSQISSKENKDLISDATEKVSIAAEDDTLDNTFSE 2692
+++S G +E + V+SQ+S+ +NK+ + + E D L
Sbjct: 1499 NKSLQEELSLARGTIERLTKSLADVESQVSA-QNKEKDTVLGRLALLQEERDKLITEMDR 1557
Query: 2693 ELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQLEAQLKS--------SLNEEKKS 2744
L + Q + ++L KL L+ LT +K +L +++S S ++K
Sbjct: 1558 SLLENQSLSSSCESL------KLA---LEGLTEDKEKLVKEIESLKSSKIAESTEWQEKH 1608
Query: 2745 KQQLEKISLLTDSLLKVFVKDTVNQLQQ-IKKTRDEKIQLSNQELLGDDQKKVTP---QD 2800
K+ ++ +L S V + ++Q ++ R EK +L + + KK T Q+
Sbjct: 1609 KELQKEYEILLQSYEN--VSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQE 1666
Query: 2801 LSQNVEEQSPSISGCFLSS-----ELEDEKEEISSPDMCPRPESP--------VFGASGQ 2847
Q +EE + S ELE+E + + + ++ P ++ AS +
Sbjct: 1667 AEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRA-EVHPAGDTAKECMETLLSSNASMK 1725
Query: 2848 EELAKRLAELE-LSREFLSALGDDQDWFDEDFGLSSSHKIQKNKAEETIVPLMAEPKRVT 2906
EEL + E E LS++F S + + +E L H+I+ N +++ + + T
Sbjct: 1726 EELERVKMEYETLSKKFQSLMSEKDSLSEEVQDL--KHQIEGNVSKQANLEATEKHDNQT 1783
Query: 2907 QQPCETLLAVPHTAEEVEILVHNAAEELWKWKELGHDLHSISIPTKLLGCASKGLDIEST 2966
E ++P EE + L + S S+P+ + D S
Sbjct: 1784 NVTEEGTQSIPGETEEQDSLSMSTRPTC-----------SESVPSAKSANPAVSKDFSSH 1832
Query: 2967 SK-RVYKQAVFDLTKEI--FEEIFAEDPNLNQPVWMKPCRINSSYFRRVKNPNNLDEIKS 3023
+ Y Q + L + I EE ++ +Q + + + S + D
Sbjct: 1833 DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQI-------STKDGELK 1885
Query: 3024 FIASEVLKLFSLKKEPNHK-TDWQKMMKFGRKKRDRVDHILVQELHEEEAQWVNYDEDEL 3082
+ EV K+ L ++ + + K+ + +++D ++ L+ +L E NY +D
Sbjct: 1886 MLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQD-- 1943
Query: 3083 CVKMQLADGIFETLIKDTIDVLNQISEKQGRML 3115
Q+ + + E+ +K+ ++++ E++ +++
Sbjct: 1944 VTDAQIKNELLESEMKNLKKCVSELEEEKQQLV 1976
Score = 73.9 bits (180), Expect = 2e-12
Identities = 318/1714 (18%), Positives = 664/1714 (38%), Gaps = 287/1714 (16%)
Query: 1332 ELSYLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEA 1391
+LS+ N EE L E+ G + A+ ES A K + + E+ +L L+ +
Sbjct: 332 KLSFHNLQEEMHHLLEQFEQA-GQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQE 390
Query: 1392 LES--------QRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETAR 1443
L+S +L + +N+ A A+++QQ+ ++ ++ + + ++ QQ ETA
Sbjct: 391 LQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETAS 450
Query: 1444 LTT------DAARQICE--MAELTRTHI-----SDAVVASGAPLAIL-YDHQRQHLPDFV 1489
T+ + + + E +A L + + A++ S L L ++++ +
Sbjct: 451 QTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITL 510
Query: 1490 KQLRTRT-ETDRKSPSVSL---------------SQSKEGTLDSKHQKYSASYDSYSESS 1533
+ + RT E DR+ +S+ E T KH++ S E+
Sbjct: 511 LEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQ 570
Query: 1534 GYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQV---QTAADDSLRSDSV 1590
+ G +E+ ++ K++ GE I + I +V T D L +
Sbjct: 571 EEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGI-APIKMKVFLEDTGQDFPLMPNEE 629
Query: 1591 PSLPD-EKDSTSIATEYSLKFDESMTEDEIEEQSFR-------SLLP--SESHR------ 1634
SLP EK+ S + + S+ + +E +S + S +P + H+
Sbjct: 630 SSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERL 689
Query: 1635 -------RFNMEKRRGHHDDSDEEASPEKTTLS-TAKELNMPFSGGQDSFSKFTME---- 1682
N K + ++ + +E + E + L+ +E +F+ + E
Sbjct: 690 KSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQL 749
Query: 1683 --MVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAE-------LAWLEHQKKHLRDKGED 1733
V++ E+RA + + L E + + E L + + K +D
Sbjct: 750 LSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKD 809
Query: 1734 DKMPPLRKKQ--------------RGLLLRLQQEKAEI-----------KRLQEANKAAR 1768
K+ L+ + R L +LQ +++E+ +++E ++A
Sbjct: 810 VKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALS 869
Query: 1769 KER-------QLILKQQEEIEKIRQT-----------TIKLQEKLKSAGESKL------- 1803
++ QL+L+++ ++E ++QT + + EK+ E K
Sbjct: 870 QKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929
Query: 1804 -------------DSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMR 1850
++ + +DN+ +S + + SP+ IS E LKK
Sbjct: 930 TLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAG-QISKEELQHEFDLLKKEN 988
Query: 1851 SRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTP 1910
+R++KL + +ELL+ RL+ E A ++ K KE+ +T
Sbjct: 989 E--------QRKRKLQAALINRKELLQRVSRLEEELANLKDESK-------KEIPLSETE 1033
Query: 1911 KKELEDQRTEQKEIASE------EESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQE 1964
+ E+E+ + E KE + + +E + L ++ + + + E + +E Q
Sbjct: 1034 RGEVEEDK-ENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQA 1092
Query: 1965 QPGSPDHSI--LTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPI 2022
+ ++ T ++ Q S L S T S +S T
Sbjct: 1093 LVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCT 1152
Query: 2023 KSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKE--QKKRQK 2080
S +H +E + + E Q ++ + + K L+K + L++E Q+K
Sbjct: 1153 GSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDY 1212
Query: 2081 ERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSAS--EKPKIKP-- 2136
RL+ Q K+ E+ + +++ + ++ + ++ + Q ++ SS E+P K
Sbjct: 1213 NRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATE 1272
Query: 2137 ---LTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVN 2193
P+ S +W S +E + S+A+ + A L E E L + +
Sbjct: 1273 QHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQ-IKAQLKEIEAEKVELELKV-SSTTS 1330
Query: 2194 EWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATS--RILDMSDGKVG- 2250
E ++E+ V + +I ++ G +E++ + E++A S + L+ S ++
Sbjct: 1331 ELTKKSEE------VFQLQEQINKQ-GLEIESLKTVSHEAEVHAESLQQKLESSQLQIAG 1383
Query: 2251 -ESSKKSEIKEIEYTKLKKSKIEDAFSKEG----KSDVLLKLVLEQGDSSEILSKKDLPL 2305
E ++ + K E KL K ED G K L K+ E + +++ L
Sbjct: 1384 LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQL 1443
Query: 2306 DSENVQ-----KDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKD 2360
+ + + K L E K EE+ +E ++ Q + +Q+ + +K +++
Sbjct: 1444 EMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQR--KLQAA--LISRKEALKEN 1499
Query: 2361 LSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKD-SQSCRDKPQPM 2419
S E L + ++ + ++SA+ + D + L L+++ + + + +
Sbjct: 1500 KSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSL 1559
Query: 2420 RSSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQV 2479
+ S ++S S + E L+E + + S + ++ TE + + E+E +
Sbjct: 1560 LENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILL 1619
Query: 2480 TESPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNN 2539
++++ +Q + + E G E +K E
Sbjct: 1620 QSYENVSNEAE----------------RIQHVVEAVRQEKQELYGKLRSTEANKKETEKQ 1663
Query: 2540 GTYDGIAYFECKEKHGIFA--PPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQND 2597
E KEK FA QKI + E D + + D +C +
Sbjct: 1664 LQEAEQEMEEMKEKMRKFAKSKQQKILELEEEND---RLRAEVHPAGDTAKECMETLLSS 1720
Query: 2598 TEGPKDR-EKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDN----VQDISGVLEAHVH 2652
K+ E+ EY E + +SL E D+ VQD+ +E +V
Sbjct: 1721 NASMKEELERVKMEY------------ETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVS 1768
Query: 2653 QQSSVDSQISSKENKDLISDATEKV-SIAAEDDTLD----NTFSEELEKQQQ-------- 2699
+Q+++++ ++ + T+ + E D+L T SE + +
Sbjct: 1769 KQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKD 1828
Query: 2700 -FTEEEDNLYAEASEKLCTPLLDL-------------LTREKNQLEAQLKSSLNEEKKSK 2745
+ +E N Y + ++L + L L EKN L +Q+ + E K +
Sbjct: 1829 FSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQ 1888
Query: 2746 QQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDE-----KIQLSNQ--EL---LGDDQKK 2795
+++ K++LL +++ ++++ ++K+T +E + +L NQ EL +G+ +
Sbjct: 1889 EEVTKMNLLNQQ-----IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQD 1943
Query: 2796 VTPQDL-SQNVEEQSPSISGCFLSSELEDEKEEI 2828
VT + ++ +E + ++ C SELE+EK+++
Sbjct: 1944 VTDAQIKNELLESEMKNLKKCV--SELEEEKQQL 1975
Score = 69.3 bits (168), Expect = 6e-11
Identities = 197/1060 (18%), Positives = 431/1060 (40%), Gaps = 127/1060 (11%)
Query: 1325 LHHRMAAELSYLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQR---HERDLA 1381
L + + ++ L A +S+ L D +R R I A++ + I+++++ E + +
Sbjct: 2176 LQENLDSTVTQLAAFTKSMSSLQD-DRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCS 2234
Query: 1382 LLKLKAEQEALESQR------QLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIA 1435
+LK + Q ++ + +LE + Q+ Q VQ Q++V + LQ ++
Sbjct: 2235 VLKDQLRQMSIHMEELKINISRLEHDK----QIWESKAQTEVQLQQKVCDTLQGENKELL 2290
Query: 1436 AQQSETARLTTDAARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTR 1495
+Q ET L + ++ ++ ++ + D + L + Q+ +L ++Q
Sbjct: 2291 SQLEETRHLYHSSQNELAKLESELKS-LKDQLTDLSNSLEKCKE-QKGNLEGIIRQQEAD 2348
Query: 1496 TETDRKSPS---VSLSQSKEGT------LDSKHQKYSASYDSYSESSGYKNHDRRSSSGS 1546
+ + S L S+E T ++ K QK + E+ + R
Sbjct: 2349 IQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDK 2408
Query: 1547 SRQESPSVPSCKENEKKLNGEKIESSID--------------EQVQTAADDSLRSDSVPS 1592
+E ++ S +E E + E+ + ++D E +Q A S+ S
Sbjct: 2409 EIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSS 2468
Query: 1593 LPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDD-SDEE 1651
L +++D I +Y + ++ ++Q + + + + R H DD + E
Sbjct: 2469 LQNDRDR--IVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSEN 2526
Query: 1652 ASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKE 1711
A + + ++LN + +DS K +E+ Q KE E + A L+ E+A E
Sbjct: 2527 AKLDAELIQYREDLNQVITI-KDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEA-NE 2584
Query: 1712 KTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLR-----------LQQEKAEIKRL 1760
+ L+ +K+ L + E K+ + ++ L+ L+ ++ E+ RL
Sbjct: 2585 DLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRL 2644
Query: 1761 QEANKAARK-----ERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNK 1815
+++K E +L+ Q+E +K+ + KL+++LK ++ +T + +
Sbjct: 2645 SALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEER 2704
Query: 1816 ATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHA-EE 1874
+E + + + E + +++ M L R HA EE
Sbjct: 2705 VAELARDLVEMEQK--LLMVTKENKGLTAQIQSFGRSMSS---------LQNSRDHANEE 2753
Query: 1875 LLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPK-------TPKKELEDQRTEQKEIASE 1927
L E KR+ DA E+ Q+++Q L +++ + + T + L +++ S+
Sbjct: 2754 LDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSK 2813
Query: 1928 EESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHS-ILTEEMICSQELES 1986
+E + L S L + + S A+ + +E DH E+ S+E +
Sbjct: 2814 DEQLLHLSSQLEDSYNQVQSF-SKAMASLQNER---------DHLWNELEKFRKSEEGKQ 2863
Query: 1987 STSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSD 2046
++ + P S+ K SS + R + +K+ Q Y L + Q T +
Sbjct: 2864 RSAAQPSTSPAEVQSLKKAMSSLQNDR--DRLLKELKNLQQQY------LQINQEIT--E 2913
Query: 2047 QSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKE--RLKAQEASL----IKQLESYDEF 2100
++ +++ +D+ + + + +L++E Q E +L+ +++S + E Y
Sbjct: 2914 LHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMA 2973
Query: 2101 IKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRG 2160
I + +LS + I+ L S+S + +PL ++ + + + + +
Sbjct: 2974 ISDKDQQLSH-------LQNLIRELRSSSS--QTQPLKVQYQRQASPETSASPDGSQ--- 3021
Query: 2161 SLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVL----RSSRKIR 2216
+L E + L+ S + + ++ L N + E+ T S L +S R+ +
Sbjct: 3022 NLVYETELLRTQLNDSLKEIHQKELRIQQLNSN-FSQLLEEKNTLSIQLCDTSQSLRENQ 3080
Query: 2217 EESGDSLENVPALH-LLKELNATSRILDMSDGKVGESS---KKSEIKEIEYTKLKKSKIE 2272
+ GD L + L ++EL A +D++ G E + +KS+ +E+ + S+ +
Sbjct: 3081 QHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQ 3140
Query: 2273 DAFSKEGKSDVLLKLVLEQGDSSEILSKKDLPLDSENVQK 2312
+ L+ +LE+ + ++ L + E +++
Sbjct: 3141 QQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRR 3180
Score = 60.5 bits (145), Expect = 3e-08
Identities = 274/1479 (18%), Positives = 573/1479 (38%), Gaps = 207/1479 (13%)
Query: 1549 QESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSL 1608
QE K + KL+ + +S+++ ++ +++ LP E S E
Sbjct: 83 QEERKAADNKIKKLKLHAKAKLTSLNKYIE-----EMKAQGGTVLPTEPQSE----EQLS 133
Query: 1609 KFDESMTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMP 1668
K D+S TE+E+E +EK + + +E S + L+ A + P
Sbjct: 134 KHDKSSTEEEME-----------------IEKIKHKLQEKEELISTLQAQLTQA-QAEQP 175
Query: 1669 FSGGQDSFSKFTMEMVRQYMKEEE-----------MRAAHQSSLLRLREKALKEKTKAEL 1717
Q S M++Q ++E+E A Q++ +REK + +T+ L
Sbjct: 176 ---AQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRL 232
Query: 1718 AWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLRLQQE------KAEIKRLQEANKAARKER 1771
H+ + L+ + D +++K R L +L++ +A++ L + A ++R
Sbjct: 233 ----HEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQR 288
Query: 1772 QLILKQQEE------------IEKIRQTTIKLQEKLK-SAGESKLDSHSDDDTKDNKATS 1818
IL QQ + +E R+ + L EK++ E KL H+ + +
Sbjct: 289 NQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHH---- 344
Query: 1819 PGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEW 1878
+ + +L+ S +++K + E+K H L +
Sbjct: 345 -------------LLEQFEQAGQAQAELESRYSALEQKHKAEMEEKT----SHILSLQKT 387
Query: 1879 KRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHL 1938
+ L + ++ + L +++ ++ ++LEDQ ++ + S+ + +PL H
Sbjct: 388 GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHE 447
Query: 1939 NSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEE----MICSQELESSTSPSKHS 1994
+ + ++ + + V E+I Q + L E ++ S ELE + ++
Sbjct: 448 TASQTSFPDVYNEGTQAVTEENIASLQKRVVE---LENEKGALLLSSIELEELKAENE-K 503
Query: 1995 LPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRI 2054
L T + Q + + R + + I + S S E E T Q E +
Sbjct: 504 LSSQITLLEAQNRTGEADREVSE--ISIVDIANKRSSSAEESGQDVLENTFSQKHKELSV 561
Query: 2055 RALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEA---ELSQD 2111
L+ + + + +L+ + K+ ++ + + +KQ+E K + + QD
Sbjct: 562 LLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQD 621
Query: 2112 LETSPTAKPQIKTL--SSASEKPKIKPLTPLHRSETAKNWKSL-TESERSRGSLESIA-- 2166
P + + + AS + + + + ++ KS + ++S ++ I
Sbjct: 622 FPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQC 681
Query: 2167 -----EHVDASLSGSE------RSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSS-RK 2214
E + + + E + + E++L AK ++ + E+F+ + S+
Sbjct: 682 HQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTA 741
Query: 2215 IREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIE-- 2272
+ EE L V L ++ EL A + L+M+ + + + + L +I
Sbjct: 742 LSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSL 801
Query: 2273 --DAFSKEGKSDVLLK----LVLEQGDSSEILSKKDLPLDSENVQKDLVGLA--IENLHK 2324
+A SK+ K +VL + L+ + S ++ + L +N + +++ A + ++
Sbjct: 802 SIEAKSKDVKIEVLQNELDDVQLQFSEQSTLI--RSLQSQLQNKESEVLEGAERVRHISS 859
Query: 2325 SEEMLKERQSDQDMNHSPN----IQSGKDIHE-QKNTKEKD-------LSWSEHLFAPKE 2372
E L + S +++ + ++ +D+ Q+ +EKD S +E + E
Sbjct: 860 KVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNE 919
Query: 2373 IPYSEDFEVSSFKKEIS---------AELYKDDFEVSSLLSLRKDSQS-----CRDKPQP 2418
+S E+ + K++++ E ++D EVSS L D S +++ Q
Sbjct: 920 EKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQH 979
Query: 2419 MRSSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTEL---MKSKERSDVEH 2475
+ + ++ K L + + L LK ++ + ER +VE
Sbjct: 980 EFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEE 1039
Query: 2476 EQQVTESPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETSFA--KGFWAGVELDK 2533
+++ E E+ + ++ + V+ +R E A + F A V+
Sbjct: 1040 DKENKEYSEKCVTSKCQEI-EIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMN 1098
Query: 2534 PEGNNNGTYDGIAYFECKEKHGIFAPPQKI--SHIPENFDDYVDINEDEDCYSDE---RY 2588
+ + E E I QK+ S+ + D V + ++ S
Sbjct: 1099 QTLQDKTNQIDLLQAEISENQAII---QKLITSNTDASDGDSVALVKETVVISPPCTGSS 1155
Query: 2589 QCYNQEQNDTEGPKDREKDVSEYFYEKSLPSVNDI-EASVNRSRSLKIETDNVQDISGVL 2647
+ + E + ++EK+ + +++L S I + + + R L+ E +D L
Sbjct: 1156 EHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRL 1215
Query: 2648 EAHVHQQSSVDSQISSKENKDLISDATEKVSIAAE---DDTLDNTFSEE-------LEKQ 2697
+ +Q SKEN++ I D ++ I D L +T +E LE+
Sbjct: 1216 QEQFDEQ--------SKENEN-IGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEP 1266
Query: 2698 QQFTEEEDNLYAEASEKLC----TPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLE-KIS 2752
E+ + LC + D + AQ+K+ L E + K +LE K+S
Sbjct: 1267 LFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVS 1326
Query: 2753 LLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNVEEQSPSI 2812
T L K + V QLQ+ + + +++ + + + + +V + L Q +E I
Sbjct: 1327 STTSELTK--KSEEVFQLQE--QINKQGLEIESLKTV-SHEAEVHAESLQQKLESSQLQI 1381
Query: 2813 SGCFLSSELEDEKEEISSPDMCPRPESPVFGASGQEELAKRLAELELSREFLSALGDDQD 2872
+G EL+ + +E+ + + E V SGQ L+E E + + +Q+
Sbjct: 1382 AGLEHLRELQPKLDELQK--LISKKEEDVSYLSGQ------LSEKEAALTKIQTEIIEQE 1433
Query: 2873 WFDEDFGLSSSHKIQKNKAEETIVPLMAEPKRVTQQPCE 2911
D L + ++Q + +E I L E + Q+P E
Sbjct: 1434 --DLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEE 1470
Score = 34.7 bits (78), Expect = 1.5
Identities = 74/332 (22%), Positives = 136/332 (40%), Gaps = 50/332 (15%)
Query: 1353 RGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALESQRQLEETRNKAAQVHAES 1412
+ +S Q + L + +K QQ++ L + + E L++Q Q + + KA Q+ E
Sbjct: 2881 KAMSSLQNDRDRLLKELKNLQQQY---LQINQEITELHPLKAQLQEYQDKTKAFQIMQEE 2937
Query: 1413 LQQVVQS-QREVTEV-LQEATCKIAAQQSETARLT--TDAARQICEMAELTRTHISDAVV 1468
L+Q S Q E+ ++ +++++ +I ++ + L +D +Q+ + L R S +
Sbjct: 2938 LRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSS-- 2995
Query: 1469 ASGAPLAILYDHQRQH----LPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSA 1524
+ PL + Y Q PD + L TE R + SL + + L + Q+ ++
Sbjct: 2996 SQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKEL--RIQQLNS 3053
Query: 1525 SYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIE--SSIDEQVQTAAD 1582
++ E + S Q + S +EN++ G+ + + +++QVQ
Sbjct: 3054 NFSQLLEEK----------NTLSIQLCDTSQSLRENQQHY-GDLLNHCAVLEKQVQELQA 3102
Query: 1583 DSLRSDSVPSLPDEKDSTSIAT------EYSLKFDESM-----TEDEIEEQSFRSLLPSE 1631
L D P P EK+ + E F E+ T E+ E R LL E
Sbjct: 3103 GPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNE--LRKLLEEE 3160
Query: 1632 SHRRFNMEK---------RRGHHDDSDEEASP 1654
+R E RR H + D +P
Sbjct: 3161 RDQRVAAENALSVAEEQIRRLEHSEWDSSRTP 3192
Score = 32.0 bits (71), Expect = 9.8
Identities = 41/200 (20%), Positives = 87/200 (43%), Gaps = 24/200 (12%)
Query: 2679 IAAEDDT-------LDNTFSEELEKQQQFTEEEDNLYAEA-SEKLCTPLLDLLTREKNQL 2730
++ +DDT LD +E + + T +ED A +E+L L D++ ++ QL
Sbjct: 16 LSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQL 75
Query: 2731 EAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLG 2790
+ + ++ E K + +++K+ L + L K ++++K + Q
Sbjct: 76 QQKDEALQEERKAADNKIKKLKLHAKAKLTSLNK----YIEEMKAQGGTVLPTEPQ---- 127
Query: 2791 DDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDEKEEISSPD---MCPRPESPVFGASGQ 2847
+++++ D S EE + +L++++E IS+ + E P ++
Sbjct: 128 -SEEQLSKHDKSSTEEEMEIE----KIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEM 182
Query: 2848 EELAKRLAELELSREFLSAL 2867
EE +L+ EF+S L
Sbjct: 183 EEFVMMKQQLQEKEEFISTL 202
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 83.2 bits (204), Expect = 4e-15
Identities = 304/1624 (18%), Positives = 648/1624 (39%), Gaps = 194/1624 (11%)
Query: 1332 ELSY-LNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQE 1390
+LSY L +IE+ + + ++L + + + + + ++LA + E +
Sbjct: 609 DLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMEND 668
Query: 1391 ALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAAR 1450
Q QLE + + E LQ ++T ++ K E TD +
Sbjct: 669 IQLYQSQLEAKKKMQVDLEKE-LQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQK 727
Query: 1451 QICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQS 1510
++ + E + ++ S + + LP V++LR E KS + + S
Sbjct: 728 ELNKEVEENEALREEVILLS----------ELKSLPSEVERLRK--EIQDKSEELHIITS 775
Query: 1511 KEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCK------ENEKKL 1564
++ L S+ + E G D ++ + + + K E + K+
Sbjct: 776 EKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKM 835
Query: 1565 NGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSF 1624
E+ E +++++ + ++ + DS SL K S T+ + + E E +
Sbjct: 836 VLEENER-MNQEIVNLSKEAQKFDS--SLGALKTELSYKTQELQEKTREVQERLNEMEQL 892
Query: 1625 RSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKE----LNMPFSGGQDSFSKFT 1680
+ L + +E+ + + ++ E TL+ K+ L +D
Sbjct: 893 KEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDI 952
Query: 1681 MEMVRQYMKEEEMRAAHQSSLLRLRE--KALKEKTKAELAWLEHQKKHLRDKGED--DKM 1736
+ V + +E SL + +E LK K E++ H +++ + ++ KM
Sbjct: 953 HDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKM 1012
Query: 1737 PPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQL--ILKQQEEIEKIRQTTIKLQEK 1794
+ KKQ Q A++K N+ ++R++ +++++ E++++ ++ I +E+
Sbjct: 1013 VGIDKKQDLEAKNTQTLTADVKD----NEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQ 1068
Query: 1795 LKSAGESKLDSHSD---------DDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQK 1845
LK+ + ++ + D+ K + + + +S + + + +K
Sbjct: 1069 LKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEK 1128
Query: 1846 LKKMRSRMDEKF--LTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKE 1903
LK+ ++ EK L ++++ + ++ E+ K L +E + ME + L K
Sbjct: 1129 LKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK- 1187
Query: 1904 LIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQ 1963
L + K + +R KE+ E+ HL E G E + I
Sbjct: 1188 LNENYEEVKSITKERKVLKELQKSFETE---RDHLRGYIREIEATGLQTKEELKIAHIHL 1244
Query: 1964 EQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLP-I 2022
++ H +E+ S +++ + L KS T + QE H Q LP +
Sbjct: 1245 KE-----HQETIDELRRSVSEKTAQIINTQDLEKSHTKL--QEEIPVLHEE--QELLPNV 1295
Query: 2023 KSHQHCYSWSDESLSMTQSETTSDQSD---IEGRIRALKDELRKRKSVVNQLKKEQKKRQ 2079
K +E +T+ TT D + IE L ++ ++ + + L KE
Sbjct: 1296 KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE----- 1350
Query: 2080 KERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTP 2139
++ LK + +L + + E I++T A++ + Q K S + K K T
Sbjct: 1351 RDNLKTIKEALEVKHDQLKEHIRETLAKIQES---------QSKQEQSLNMKEKDNETT- 1400
Query: 2140 LHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSER--SLSAYAKRVNEWDS 2197
K ++E E+ + +S ++ + G + + E + + AK ++
Sbjct: 1401 ----------KIVSEMEQFKPK-DSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQR 1449
Query: 2198 RTEDFQTPSPVLRSS-RKIREESGDSLENVPALHL-LKELNATSRILDMSDGKVGESSKK 2255
E Q+ S L+ + ++I + ++ E + H LKE T +++ +V S K+
Sbjct: 1450 LQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEET-----INELRVNLSEKE 1504
Query: 2256 SEI----KEIEYTKLK-KSKIEDAFSKEGKSDV-----LLKLVLEQGDSSEILSKKDLPL 2305
+EI K++E K ++KI++ + KE + ++ + + V E E KD L
Sbjct: 1505 TEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSAL 1564
Query: 2306 DS-ENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWS 2364
S E+ +L E+ + + M+KE++ + + + I+ + ++NTKE
Sbjct: 1565 QSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQ---LKENTKEIVAKMK 1621
Query: 2365 EHLFAPKEIPYSEDFEVSSFKKEI-SAELYKDDFEVSSLLSLRKDSQSCR------DKPQ 2417
E KE + + V+ ++++ E K+ FE L ++++ R + +
Sbjct: 1622 ES--QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLE 1679
Query: 2418 PMRSSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQ 2477
MRS T S + E L + + N+ +L+ EL K EH++
Sbjct: 1680 EMRSVTKERDDLRS---VEETLKVERDQLKENLRETITRDLEKQEEL-KIVHMHLKEHQE 1735
Query: 2478 QVTESPSLASVPTAD---------------ELFDFHIGDRVLIGNVQPGILRFKGETSFA 2522
+ + + S T + + D I + + I ++ L+ + ET
Sbjct: 1736 TIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMH---LKEQQET--- 1789
Query: 2523 KGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYV----DINE 2578
+DK G + D ++ + ++ +KI + N + D+NE
Sbjct: 1790 --------IDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNE 1841
Query: 2579 DEDCYSD-ERYQCYNQEQNDTEGPKDREK-DVSEYFYE--KSLPSVNDIEASVNR-SRSL 2633
+ S+ E+ + ++Q+ T + E ++++ +E + + SV ++ R +L
Sbjct: 1842 TQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETL 1901
Query: 2634 KIETDNVQDISGVLEAH--VHQQSSVDSQISSKENKDLISDATEKVS-----IAAEDDTL 2686
K+E D +++ +A QQ +++ SKE+K+ + EK+S I+ L
Sbjct: 1902 KLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDL 1961
Query: 2687 DNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQ 2746
D + E +K Q+ ++E L + +++ ++ N++E QLK + S Q
Sbjct: 1962 DKSKDELQKKIQELQKKELQLLRVKED------VNMSHKKINEME-QLKKQFEAQNLSMQ 2014
Query: 2747 QLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNVE 2806
+ + + L + +++ +++ + K RDE ++ + DQ T +++
Sbjct: 2015 SVR----MDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDR 2070
Query: 2807 EQSPSISGCFLSSELEDEKEEISSPDMCPRPESPVFGASGQEELAKRLAELELSREFLSA 2866
+ + +++ EK +S ES S +EL KR +E++ E L+
Sbjct: 2071 Q----------NHQVKPEKRLLSDGQQ-HLTESLREKCSRIKELLKRYSEMDDHYECLNR 2119
Query: 2867 LGDD 2870
L D
Sbjct: 2120 LSLD 2123
Score = 79.0 bits (193), Expect = 7e-14
Identities = 283/1551 (18%), Positives = 617/1551 (39%), Gaps = 229/1551 (14%)
Query: 1337 NAIEESVRQLSDVERVRGISLAQQESVSL-AQIIKAQQQ--RHERDLALLKLKAEQEALE 1393
+ I E + +D++ +++ QE + L +K QQ+ E++ A+ K +
Sbjct: 1061 SVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCD 1120
Query: 1394 SQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEAT-----------CKIAAQQSETA 1442
++EE + +Q E QQ++ Q E++E+ ++ ++ + ET
Sbjct: 1121 RLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETE 1180
Query: 1443 RLTTDAARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRT---RTETD 1499
RL + A+++ E E ++ + V L ++ +R HL +++++ +T+ +
Sbjct: 1181 RL--ELAQKLNENYEEVKSITKERKVLK--ELQKSFETERDHLRGYIREIEATGLQTKEE 1236
Query: 1500 RKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKE 1559
K + L + +E T+D + S +++ N S + QE +P E
Sbjct: 1237 LKIAHIHLKEHQE-TIDELRRSVS------EKTAQIINTQDLEKSHTKLQEE--IPVLHE 1287
Query: 1560 NEKKLNGEKIESSIDE---QVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDE--SM 1614
++ L K S E +++ + S DS E + + ++ +E S+
Sbjct: 1288 EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSL 1347
Query: 1615 TEDEIEEQSFRSLLPSE-----SHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNM-- 1667
T++ ++ + L + H R + K + ++ + ++ T K ++
Sbjct: 1348 TKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEME 1407
Query: 1668 PFSGGQDSFSKFTMEMV----RQYMKEEEMR--AAHQSSLLRLREKALKEKTKAELAWLE 1721
F + + +EM+ R +EM+ A + L RL+E E + + E
Sbjct: 1408 QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKE 1467
Query: 1722 HQKKHLRDKGEDDKMPPLRKKQRG----LLLRLQQEKAEIKRLQEANKAARKERQLILKQ 1777
KHL + E K+Q L + L +++ EI +Q+ +A + Q K
Sbjct: 1468 IVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQN--KI 1525
Query: 1778 QEEIEKIRQTTIK----LQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPIS 1833
QE EK Q IK +QEK+ + K KD+ S LE +
Sbjct: 1526 QEIYEKEEQFNIKQISEVQEKVNELKQFK----EHRKAKDSALQSIESKMLELTNRLQ-- 1579
Query: 1834 ISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQME 1893
S E IM K K+ R+ E +R+Q +++ +E++ + +++E E + ++
Sbjct: 1580 -ESQEEIQIMIKEKEEMKRVQEALQIERDQL----KENTKEIVA--KMKESQEKEYQFLK 1632
Query: 1894 KQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAV 1953
A+ +++ + + K++ E Q+ + I +E + L L+ EE+ S
Sbjct: 1633 MTAVNETQEKMCEIEHLKEQFETQKLNLENIETEN---IRLTQILHENL---EEMRSVTK 1686
Query: 1954 EYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCT-SVSKQESSKGSH 2012
E S+ + L+ K +L ++ T + KQE K
Sbjct: 1687 ERDDLRSV-------------------EETLKVERDQLKENLRETITRDLEKQEELK--- 1724
Query: 2013 RTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLK 2072
H+ +K HQ +S +E ++ Q D+E ALK + K + +
Sbjct: 1725 ----IVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAH 1780
Query: 2073 KEQKKRQK--ERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASE 2130
K++Q+ ++L+ + +L + + ++ + A+L + ++ + Q+ TL
Sbjct: 1781 MHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLK---- 1836
Query: 2131 KPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHV-DASLSGSERSVSERSLS-AY 2188
K + E+++ +E + + + D SL+ S+ + +L+
Sbjct: 1837 -------------------KDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKL 1877
Query: 2189 AKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPA--LHLLKELNATSRILDMSD 2246
+ + E S ++ V + + R++ +SL+ A L + +EL +
Sbjct: 1878 HENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHK 1937
Query: 2247 GKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSKKDLPLD 2306
V + +K K I+ + ++K + D L K + E L KK+L L
Sbjct: 1938 ETVDKLREKISEKTIQISDIQK-------DLDKSKDELQKKIQE-------LQKKELQL- 1982
Query: 2307 SENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHS---PNIQSGKDIHEQKN-----TKE 2358
V++D V ++ + +++ E++ K+ ++ S N Q K +HE KE
Sbjct: 1983 -LRVKED-VNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE 2040
Query: 2359 KDLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQ-----SCR 2413
+D E + + D +++ ++ I+ + + + +V L D Q S R
Sbjct: 2041 RD----ELRRIKESLKMERDQFIATLREMIARD--RQNHQVKPEKRLLSDGQQHLTESLR 2094
Query: 2414 DKPQPMRSSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDV 2473
+K ++ + ++ ECL+ SL + + + L ++ L S
Sbjct: 2095 EKCSRIKELLK---RYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANL--SLPYLQT 2149
Query: 2474 EHEQQVTESPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDK 2533
+H +++ + S+ +FH R + + + ++ ++
Sbjct: 2150 KHIEKLFTANQRCSM-------EFH---------------RIMKKLKYVLSYVTKIKEEQ 2187
Query: 2534 PEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFD------DYVDINEDEDCYSDER 2587
E N D I E K+K + KI H+ ++ D + +N++ D + +E
Sbjct: 2188 HESINKFEMDFIDEVE-KQKELLI----KIQHLQQDCDVPSRELRDLKLNQNMDLHIEEI 2242
Query: 2588 YQCYNQEQ-----NDTEGPKDREKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNVQD 2642
+ +++ + + + K++++ F E+ L + DIE N ++ E D +
Sbjct: 2243 LKDFSESEFPSIKTEFQQVLSNRKEMTQ-FLEEWLNTRFDIEKLKN---GIQKENDRICQ 2298
Query: 2643 ISGVLE----AHVHQQSSVDSQ---ISSKENKDLISDATEKVSIAAEDDTLDNTFSEELE 2695
++ A +++ + + + IS + +DL S + + TL + +
Sbjct: 2299 VNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLA---S 2355
Query: 2696 KQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLT 2755
Q +DN + + + + +N L +S++++E K + +++ +
Sbjct: 2356 GAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTN 2415
Query: 2756 DSLLKVFVKDTVNQLQQ-IKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNV 2805
D + K+ K V++ + ++KT++ L ++ LG K +DL +
Sbjct: 2416 DIIAKLQAK--VHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKL 2464
Score = 56.2 bits (134), Expect = 5e-07
Identities = 235/1322 (17%), Positives = 508/1322 (38%), Gaps = 163/1322 (12%)
Query: 1706 EKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLRLQQ--EKAEIKRLQEA 1763
++AL ++ + E+ L KK L + + + + K Q LL + +K + ++++
Sbjct: 341 DEALLKRYRKEIMDL---KKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENL 397
Query: 1764 NKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTD 1823
+ L L+Q+ + ++ R+ T L K+ S + T T +
Sbjct: 398 TRMLVTSSSLTLQQELKAKRKRRVTWCLG-KINKMKNSNYADQFNIPTNITTKTHKLSIN 456
Query: 1824 LETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKR--EQKLMQRRQHAEEL-LEWKR 1880
L + S S+ + L ++ K L + E +L R + L L++++
Sbjct: 457 LLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQ 516
Query: 1881 -RLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLN 1939
R + EE E++ EK L + E ++ KT K + + ++ E + L H
Sbjct: 517 LRTEKEEMELKLKEKNDLDEF--EALERKTKKDQ-------EMQLIHEISNLKNLVKHAE 567
Query: 1940 SESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSC 1999
+ E S VE + + D +E I SQ+LE+ K L S
Sbjct: 568 VYNQDLENELSSKVELLREKE---------DQIKKLQEYIDSQKLENI----KMDLSYSL 614
Query: 2000 TSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKD 2059
S+ + K + L K + L E + +E I+ +
Sbjct: 615 ESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQS 674
Query: 2060 ELRKRKSVVNQLKKEQKKRQKERLKAQEA-------SLIKQLESYDEFIKKTEAELSQDL 2112
+L +K + L+KE + E K L+ LE + I + EL++++
Sbjct: 675 QLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGK-ITDLQKELNKEV 733
Query: 2113 ETSPTAKPQIKTLSSASEKP-KIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDA 2171
E + + ++ LS P +++ L R E + L + L S H ++
Sbjct: 734 EENEALREEVILLSELKSLPSEVERL----RKEIQDKSEELHIITSEKDKLFSEVVHKES 789
Query: 2172 SLSG--SERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPAL 2229
+ G E ++ L+ D ++F+T K+ E + + N +
Sbjct: 790 RVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERM-NQEIV 848
Query: 2230 HLLKE-------LNATSRILDMSDGKVGESSKKSE--IKEIEYTKLKKSKIEDAFSKEGK 2280
+L KE L A L ++ E +++ + + E+E K + + +
Sbjct: 849 NLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVER 908
Query: 2281 SDVLLKLVLEQG--DSSEILSKKD--------LPLDSENVQKDL---VGLAI---ENLHK 2324
L+ L+Q + + +KD L ++ + ++ D+ V + I E L
Sbjct: 909 EKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRN 968
Query: 2325 SEEMLKERQSD-QDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSEDFEVSS 2383
+ E LK+ Q + + + +++H ++NT E + + + I +D E +
Sbjct: 969 ALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVG---IDKKQDLEAKN 1025
Query: 2384 FKKEISAELYKDDF--EVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEISECLSE 2441
+ ++A++ ++ + + SL ++ +++ Q M S E++ L E
Sbjct: 1026 -TQTLTADVKDNEIIEQQRKIFSLIQE----KNELQQMLESV-----IAEKEQLKTDLKE 1075
Query: 2442 KSLSIHSNVHSDRLL--ELKSPTELMKSKERSDVEHEQQVTES-PSLASVPTADELFDFH 2498
N RLL ELK E++ ++ ++ E +++ + LA V +
Sbjct: 1076 NIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQ 1135
Query: 2499 IGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFA 2558
+ ++ Q +L + E S E+ K + + E +H
Sbjct: 1136 LQEK------QQQLLNVQEEMS---------EMQKKINEIENLKNELKNKELTLEHMETE 1180
Query: 2559 PPQKISHIPENFDDYVDINEDEDCYSD---------ERYQCYNQEQNDTEGPKDREKDVS 2609
+ + EN+++ I ++ + + + Y +E T E ++
Sbjct: 1181 RLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIA 1240
Query: 2610 EYFYEKSLPSVNDIEASVNRSRSLKIETDNVQDISGVLEAHV---HQQSSV--------D 2658
++ +++++ SV+ + I T +++ L+ + H++ + +
Sbjct: 1241 HIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSE 1300
Query: 2659 SQISSKENKDLISDATEKVS-----IAAEDDTLDNTFSEELEKQQQFTEEEDNL--YAEA 2711
+Q + E + L +T K S I E L+ F E E+ + T+E DNL EA
Sbjct: 1301 TQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEA 1360
Query: 2712 SEKLCTPLLDLL---------TREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVF 2762
E L + + ++ K + +K NE K ++E+ +LL++
Sbjct: 1361 LEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIE 1420
Query: 2763 VKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSELE 2822
+ + + ++++++ DE ++ ++ DD +++ Q++ Q+ +Q ++ LE
Sbjct: 1421 I-EMLGLSKRLQESHDEMKSVAKEK---DDLQRL--QEVLQSESDQLKENIKEIVAKHLE 1474
Query: 2823 DEKEEISSPDMCPRPESPVFGASGQEELAKRLAELELSREFLSALGDD-----QDWF--D 2875
E EE+ C + + + L+++ E+ ++ L A+ D Q+ + +
Sbjct: 1475 TE-EELKVAHCCLKEQEETINEL-RVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKE 1532
Query: 2876 EDFGLSSSHKIQKNKAEETIVPLMAEPKRVTQQPCETLL-----AVPHTAEEVEILVHNA 2930
E F + ++Q+ E + K Q E+ + + + EE++I++
Sbjct: 1533 EQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEK 1592
Query: 2931 AE 2932
E
Sbjct: 1593 EE 1594
Score = 38.9 bits (89), Expect = 0.080
Identities = 164/873 (18%), Positives = 336/873 (38%), Gaps = 163/873 (18%)
Query: 1339 IEESVRQLSDVERVRGISLAQQESVSLAQI--IKAQQQRHERDLALLKLKAEQEALESQR 1396
+ E+ +++S++E+++ Q ++S +I + Q+ HE L ++K+ + ++ R
Sbjct: 1839 VNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHEN---LEEMKSVMKERDNLR 1895
Query: 1397 QLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMA 1456
++EET ESLQ+ E+ + L K A S+ + T D R+ +++
Sbjct: 1896 RVEETLKLERDQLKESLQETKARDLEIQQEL-----KTARMLSKEHKETVDKLRE--KIS 1948
Query: 1457 ELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRT-ETDRKSPSVSLSQSKEGTL 1515
E T ISD + D + L +++L+ + + R V++S K +
Sbjct: 1949 EKT-IQISD--------IQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEM 1999
Query: 1516 DSKHQKYSAS--------YDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGE 1567
+ +++ A D++ + K H+ +E + KE+ K+ +
Sbjct: 2000 EQLKKQFEAQNLSMQSVRMDNFQLTK--KLHESLEEIRIVAKERDELRRIKES-LKMERD 2056
Query: 1568 KIESSIDEQV-------QTAADDSLRSDSVPSLPDE-KDSTSIATEYSLKFDES------ 1613
+ +++ E + Q + L SD L + ++ S E ++ E
Sbjct: 2057 QFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYEC 2116
Query: 1614 ---MTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDD----SDEEASPE--------KTT 1658
++ D +E F+ L ++ + H + +++ S E K
Sbjct: 2117 LNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYV 2176
Query: 1659 LSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEM----RAAHQSSLLRLRE-KALKEKT 1713
LS ++ +S +KF M+ + + K++E+ + Q + RE + LK
Sbjct: 2177 LSYVTKIK---EEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQ 2233
Query: 1714 KAELAWLEHQKKHLRD---------KGEDDKMPPLRKKQRGLLLRLQQEKAEIKRLQ--- 1761
+L H ++ L+D K E ++ RK+ L + +I++L+
Sbjct: 2234 NMDL----HIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGI 2289
Query: 1762 --------EANKAARKERQLILKQQEEIEKIRQTTIKLQEK----LKSAGESKLDSHSDD 1809
+ N I+ + E E+ T K E+ LK E ++
Sbjct: 2290 QKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTL 2349
Query: 1810 DTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQRR 1869
T PT + ++P S ++ T+ +++L+ E + K E K+++ +
Sbjct: 2350 KTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK-ESKIIKMQ 2408
Query: 1870 QHAEELLEWKRRLDAEEAE----IRQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIA 1925
+ E + +L A+ E + + ++ DK + K K+E+ED + + +I
Sbjct: 2409 KELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKID 2468
Query: 1926 SEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELE 1985
E+ N++ E + A E I +L E + SQ+ +
Sbjct: 2469 LEKMK--------NAKEFEKEISATKATVEYQKEVI----------RLLRENLRRSQQAQ 2510
Query: 1986 SSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTS 2045
++ S+H+ P Q S+K GG + Q+
Sbjct: 2511 DTSVISEHTDP--------QPSNKPLTCGGGS-------------------GIVQNT--- 2540
Query: 2046 DQSDIEGRIRALKDELRKRKSVVNQLKK--EQKKRQKERLKAQEASLIKQLESYDEFIKK 2103
+ LK E + + +++LK+ EQ +QK L + L +++++ E K
Sbjct: 2541 -------KALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLK 2593
Query: 2104 TEAELSQDLETSPTAKPQIKTLSSASEKPKIKP 2136
EA E SP + K +AS+K +I P
Sbjct: 2594 REAHKQVTCENSPKSP---KVTGTASKKKQITP 2623
Score = 35.4 bits (80), Expect = 0.89
Identities = 41/198 (20%), Positives = 81/198 (40%), Gaps = 31/198 (15%)
Query: 478 DVLHRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPI-----EIRGIL 532
DV + + S + +N ++++ S+ K++ T L ++ E+R +
Sbjct: 1032 DVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLG 1091
Query: 533 DDLQLDSTAHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYD 592
D+L+ KQ + Q + HA + + R D++ E+ K +
Sbjct: 1092 DELK--------KQQEIVAQEKN-----HAIKKEGELSRTCDRLAEVEEK---LKEKSQQ 1135
Query: 593 TDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQ---------ELYRKQKEAFTKV 643
E +Q ++ QEE Q + + + E KNK L EL +K E + +V
Sbjct: 1136 LQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEV 1195
Query: 644 KNVPPSEPSATRRLQETY 661
K++ E + LQ+++
Sbjct: 1196 KSI-TKERKVLKELQKSF 1212
Score = 33.9 bits (76), Expect = 2.6
Identities = 66/358 (18%), Positives = 155/358 (43%), Gaps = 53/358 (14%)
Query: 2603 DREKDVSEYFYEKS-----LPSVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSV 2657
+++K SE +++S L + + + ++S TD L Q+ +
Sbjct: 776 EKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKM 835
Query: 2658 DSQISSKENKDLISDATEKVSIAAEDDTLDNTFS---EELEKQQQFTEEEDNLYAEASEK 2714
+ + + N+++++ + E + L S +EL+++ + +E N + E+
Sbjct: 836 VLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQ 895
Query: 2715 LCT--PLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSL------LKVFVKDT 2766
L L + REK + +L+ +L E K Q+ + + L +SL LK + DT
Sbjct: 896 LENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDT 955
Query: 2767 VNQ----LQQIKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSELE 2822
VN +Q++ + Q +QE + + K++ +++S+N+ + + E +
Sbjct: 956 VNMNIDTQEQLRNALESLKQ--HQETINTLKSKIS-EEVSRNLHMEEN-------TGETK 1005
Query: 2823 DEKEEISSPDMCPRPESPVFGASGQEELAKRLAELELSREFLSALGDDQDWFDEDFGLSS 2882
DE ++ + G +++L + + + L+A D + ++ + S
Sbjct: 1006 DEFQQ------------KMVGIDKKQDLEAK------NTQTLTADVKDNEIIEQQRKIFS 1047
Query: 2883 SHKIQKNKAEETIVPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKEL 2940
+ +KN+ ++ + ++AE +++ E + EE+ +L +EL K +E+
Sbjct: 1048 LIQ-EKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLL----GDELKKQQEI 1100
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 83.2 bits (204), Expect = 4e-15
Identities = 291/1386 (20%), Positives = 543/1386 (39%), Gaps = 228/1386 (16%)
Query: 1508 SQSKEGT-LDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNG 1566
++ EGT L ++Q+ +S ++ +H+ + + + S K+ +KL
Sbjct: 57 NEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQ 116
Query: 1567 E----KIESSIDEQVQTAADDSLRSDSVPS-------LPDEKDSTSIATEYSLKFDESMT 1615
E K E +Q +AD SL + P P + S S + K+++ +
Sbjct: 117 ELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE 176
Query: 1616 EDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDS 1675
E + E ++L ++ + + H D + +AS + S +E
Sbjct: 177 ERKRLEAEVKALQAKKASQTLP-QATMNHRDIARHQAS--SSVFSWQQEKTPSHLSSNSQ 233
Query: 1676 FSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKK-HLRDKGEDD 1734
+ + Y E+ +S+L K A ++ ++ HL D+ +
Sbjct: 234 RTPIRRDFSASYFSGEQEVTPSRSTLQI-------GKRDANSSFFDNSSSPHLLDQLKAQ 286
Query: 1735 KMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEK 1794
LR K L LRLQ + E+K + NK + QL + E IEK EK
Sbjct: 287 NQE-LRNKINELELRLQGHEKEMKG--QVNKFQELQLQLEKAKVELIEK---------EK 334
Query: 1795 LKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMD 1854
+ + +L R+ + +S++ +++ QKLKK+
Sbjct: 335 VLNKCRDEL----------------------VRTTAQYDQASTKYTALEQKLKKLTED-- 370
Query: 1855 EKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKEL 1914
L+ + Q R E+ ++ K + EE +Q Q L D+E I+ K +
Sbjct: 371 ---LSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTL---DQECIQMKARLTQE 424
Query: 1915 EDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSIL 1974
Q + L + L+ +S+ ++L + E+
Sbjct: 425 LQQAKNMHNV---------LQAELDKLTSVKQQLENNLEEF------------------- 456
Query: 1975 TEEMICSQELESSTSPSKHS-LPKSCTSVSKQESSKGSH---RTGGQCHLP--IKSHQHC 2028
++ +C E S K + L +S + K+ + SH + CHL +K+ + C
Sbjct: 457 -KQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQC 515
Query: 2029 YSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQEA 2088
+ S +++ TS ++ LR + +NQ ++ E+LK A
Sbjct: 516 LNQSQNFAEEMKAKNTSQET-----------MLRDLQEKINQ---QENSLTLEKLKLAVA 561
Query: 2089 SLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPK-----IKPLTPLHRS 2143
L KQ + + +KK E + Q + + + K L SA E K +K L
Sbjct: 562 DLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSC 621
Query: 2144 ETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQ 2203
++N K LT+ E + +L+S H++ L + E Y +RV + E+
Sbjct: 622 WKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHE-----YNERVRTLEMDRENL- 675
Query: 2204 TPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEY 2263
S +R+ + + +E T ++ M + E S + KEIE
Sbjct: 676 --SVEIRNLHNVLDSKSVEVE-------------TQKLAYMELQQKAEFSDQKHQKEIEN 720
Query: 2264 TKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSK----KDLPLDSENVQKDLVGLAI 2319
LK S++ D+ KL L S+EI+ K +DL + E++ +DL+
Sbjct: 721 MCLKTSQLTGQV-----EDLEHKLQLL---SNEIMDKDRCYQDLHAEYESL-RDLLKSKD 771
Query: 2320 ENLHKSEEMLKERQS-DQD--MNHS-PNI--QSGKDIHEQKNTK-EKDLSWSEHLFAPKE 2372
+L +E+ + + DQ M+HS NI + G E+ + E D S
Sbjct: 772 ASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNR 831
Query: 2373 IPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSN 2432
+ S +F + S +K+++++L K + L+ ++ + + K + M S TS
Sbjct: 832 VD-SLEFSLES-QKQMNSDLQK---QCEELVQIKGEIEENLMKAEQMHQSFVAETS---- 882
Query: 2433 EEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESPSLASVPTAD 2492
+ IS+ ++ S H NV ++ L L++ K KE + +++ TE + + ++
Sbjct: 883 QRISKL--QEDTSAHQNVVAETLSALEN-----KEKE-LQLLNDKVETEQAEIQELKKSN 934
Query: 2493 ELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPE----GNNNGTYDGIAYF 2548
L + + + L+ L K +S + L+K E NGT I
Sbjct: 935 HLLEDSLKELQLLSETLS--LEKKEMSSI-------ISLNKREIEELTQENGTLKEINAS 985
Query: 2549 ECKEKHGIFAPPQKISHIPENFDDYVD-----INEDEDCYSDERYQCYNQEQNDTEGPKD 2603
+EK + QK E+F +Y+D I+E D Y E+ + E +
Sbjct: 986 LNQEKMNLI---QK----SESFANYIDEREKSISELSDQYKQEKLILLQR----CEETGN 1034
Query: 2604 REKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISS 2663
+D+S+ Y+ + + +E +N SL N + A HQ+ +
Sbjct: 1035 AYEDLSQK-YKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAE 1093
Query: 2664 KENKDLISDATEKVSIAAEDDTLDNTFSEELE----KQQQFT-EEEDNLYAEASEKLCTP 2718
+ N++L+ + E V A + DN + + E KQ+ T +EE N + L
Sbjct: 1094 ERNQNLMLE-LETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQE 1152
Query: 2719 LLDLLTREKNQLEAQ------LKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVN---- 2768
L+ K + E Q +++S+ E + + Q D +K D+ N
Sbjct: 1153 NEQLMKVMKTKHECQNLESEPIRNSVKERESERNQC-NFKPQMDLEVKEISLDSYNAQLV 1211
Query: 2769 QLQQIKKTRDEKIQLS--NQELLGDDQKKVTPQDLSQNVEE-QSPSISGCFLSSELEDEK 2825
QL+ + + ++ K+Q S +E L + + + + N+++ QS ISG E++ E+
Sbjct: 1212 QLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISG-LKDCEIDAEE 1270
Query: 2826 EEISSP 2831
+ IS P
Sbjct: 1271 KYISGP 1276
Score = 65.1 bits (157), Expect = 1e-09
Identities = 178/885 (20%), Positives = 339/885 (38%), Gaps = 147/885 (16%)
Query: 1334 SYLNAIEESVRQLSDVERVRGISLAQQE-SVSLAQIIKAQQQRHERDLALLKLKAEQEAL 1392
S + +E R+L E + + + E S + + +K Q + R L + +L
Sbjct: 2151 SLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRS 2210
Query: 1393 ESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQI 1452
E + ++ + K Q+ L +++ S + + E ++A +I + + + Q+
Sbjct: 2211 EKENLTKQIQEKQGQL--SELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQN---QL 2265
Query: 1453 CEMAELTRTHISDAVVASGAPLAILYDHQRQH-LPDFVKQLRTRTETDRKSPSVSLSQSK 1511
E+ E D + ++ + +H L + +++LR R E D K L Q K
Sbjct: 2266 KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLK 2325
Query: 1512 EGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIES 1571
E + K +N +R + QE ++ + EN K E +++
Sbjct: 2326 ESEHHADLLK-----------GRVENLERELEIARTNQEHAALEA--ENSKG-EVETLKA 2371
Query: 1572 SIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRSLLPSE 1631
I+ Q+ L V ++ EK++ T K E ++E EI SF ++L +
Sbjct: 2372 KIEGMTQSLRGLEL---DVVTIRSEKENL---TNELQKEQERISELEIINSSFENILQEK 2425
Query: 1632 SHRRFNMEKRRGHHDDSDEEASPEKTTLSTA-KELNMPFSGGQDSFSKFTMEMVRQYMKE 1690
+ M+ E++S L T KELN + + ++ K
Sbjct: 2426 EQEKVQMK----------EKSSTAMEMLQTQLKELNERVAALHND---------QEACKA 2466
Query: 1691 EEMRAAHQSSLLRLREKALKE---KTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGLL 1747
+E + Q L L + L + + K L+ L + ED K +K +
Sbjct: 2467 KEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISR 2526
Query: 1748 LRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLDSHS 1807
L+ Q + E Q +K ++ E + L +++ +E +R T++L++K++ +SK + S
Sbjct: 2527 LKNQIQDQE----QLVSKLSQVEGEHQLWKEQNLE-LRNLTVELEQKIQVL-QSK--NAS 2578
Query: 1808 DDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQ 1867
DT + +S + E + ++ + S ++K+ KM ++ E L + ++ Q
Sbjct: 2579 LQDTLEVLQSSYKNLENE------LELTKMDKMSFVEKVNKMTAKETE--LQREMHEMAQ 2630
Query: 1868 RRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKEL-IKPKTPKKELEDQRTEQKEIAS 1926
+ +E L ++ A E ++ E ++ KEL ++ KK L+ +Q E
Sbjct: 2631 KTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVE--- 2687
Query: 1927 EEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELES 1986
E + EE+ + +E H L + E+E
Sbjct: 2688 -------------KEGKVREEIAEYQLRLHEAEK---------KHQALLLDTNKQYEVEI 2725
Query: 1987 STSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSD 2046
T K + + C S K E +KS S E L+ + TT
Sbjct: 2726 QTYREKLTSKEECLSSQKLEIDL------------LKS-------SKEELNNSLKATTQ- 2765
Query: 2047 QSDIEGRIRALKDELRKRK----SVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIK 2102
+ +EL+K K VNQLKKE ER + + LIK + +E +
Sbjct: 2766 ----------ILEELKKTKMDNLKYVNQLKKE-----NERAQGKMKLLIKSCKQLEEEKE 2810
Query: 2103 KTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTES--ERSRG 2160
+ ELSQ L +A EK K + E K L E+ E+++
Sbjct: 2811 ILQKELSQ--------------LQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKE 2856
Query: 2161 SLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTP 2205
+ E + ++ +S + ++ L + S+ + +P
Sbjct: 2857 ADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSP 2901
Score = 62.0 bits (149), Expect = 9e-09
Identities = 301/1622 (18%), Positives = 600/1622 (36%), Gaps = 302/1622 (18%)
Query: 1332 ELSYLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEA 1391
+L L A + +Q + E+ G +L ++E+ L +I ++ ++ + K+ E +
Sbjct: 40 QLDSLEAALQKQKQKVENEKTEGTNL-KRENQRLMEICESLEKTKQ------KISHELQV 92
Query: 1392 LESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQ 1451
ESQ +E + + + E L+Q ++ CK ++S+ A + D +
Sbjct: 93 KESQVNFQEGQLNSGKKQIEKLEQELK------------RCKSELERSQQAAQSADVSLN 140
Query: 1452 ICEMAE-LTRTHISDAVVASGAPLAILYD------HQRQHLPDFVKQLRTRTETD----- 1499
C + + T ++ + SG+ L + +R+ L VK L+ + +
Sbjct: 141 PCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQA 200
Query: 1500 ---------RKSPSVSLSQSKEGT---LDSKHQK------YSASYDSYSES---SGYKNH 1538
++ S S +E T L S Q+ +SASY S + S
Sbjct: 201 TMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQ 260
Query: 1539 DRRSSSGSSRQESPSVPSC-------------KENEKKLNGEKIESSIDEQVQTAADDSL 1585
+ + SS ++ S P K NE +L + E + QV + L
Sbjct: 261 IGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQL 320
Query: 1586 RSD--SVPSLPDEKDSTSIATEY---SLKFDESMTEDEIEEQSFRSLLPSESHRRFNMEK 1640
+ + V + EK E + ++D++ T+ EQ + L S +R N E
Sbjct: 321 QLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAES 380
Query: 1641 RRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSS 1700
R S E+ KE S Q SF E ++ MK + Q+
Sbjct: 381 AR---------CSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQ--MKARLTQELQQA- 428
Query: 1701 LLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLRLQQEKAEIKRL 1760
K + +AEL L K+ L + E+ K R +Q Q + + L
Sbjct: 429 ------KNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQ-----AFQASQIKENEL 477
Query: 1761 QEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPG 1820
+ + + +KE L+ E +K R+ L+ +LK+ + S + + K TS
Sbjct: 478 RRSMEEMKKENNLLKSHSE--QKARE-VCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQE 534
Query: 1821 P--TDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEW 1878
DL+ + I+ E S ++KLK + ++++ Q L+++R+H E L
Sbjct: 535 TMLRDLQEK------INQQENSLTLEKLKLAVADLEKQ--RDCSQDLLKKREHHIEQLND 586
Query: 1879 KRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHL 1938
K + + EK++ A +K KKE E+ + E+ + + L + +
Sbjct: 587 K---------LSKTEKESKALLSALELK----KKEYEELKEEKTLFSCWKSENEKLLTQM 633
Query: 1939 NSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKS 1998
SE E L S Q + + + T EM +E S + H++ S
Sbjct: 634 ESEK---ENLQSKINHLETCLKTQQIKSHEYNERVRTLEM--DRENLSVEIRNLHNVLDS 688
Query: 1999 CTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALK 2058
SV + + + HQ E++ + S+ T D+E +++ L
Sbjct: 689 -KSVEVETQKLAYMELQQKAEFSDQKHQK----EIENMCLKTSQLTGQVEDLEHKLQLLS 743
Query: 2059 DELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTA 2118
+E+ + L E + ++ LK+++ASL+ T
Sbjct: 744 NEIMDKDRCYQDLHAEYES-LRDLLKSKDASLV-------------------------TN 777
Query: 2119 KPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSER 2178
+ ++L + ++P + H + SERS LE+ ++++ +
Sbjct: 778 EDHQRSLLAFDQQPAMH-----HSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRV 832
Query: 2179 SVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNAT 2238
E SL + + ++ + E+ +I+ E ++L +H +
Sbjct: 833 DSLEFSLESQKQMNSDLQKQCEELV----------QIKGEIEENLMKAEQMHQSFVAETS 882
Query: 2239 SRILDMSD------GKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQG 2292
RI + + V E+ E KE E +L K+E ++ + E
Sbjct: 883 QRISKLQEDTSAHQNVVAETLSALENKEKE-LQLLNDKVETEQAE----------IQELK 931
Query: 2293 DSSEIL--SKKDLPLDSENV---QKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSG 2347
S+ +L S K+L L SE + +K++ + N + EE+ +E + +++N S N
Sbjct: 932 KSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLN---- 987
Query: 2348 KDIHEQKNTKEKDLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLRK 2407
E+ N +K SE F ++E S D ++ L+ L
Sbjct: 988 ---QEKMNLIQK----------------SESFANYIDEREKSISELSDQYKQEKLILL-- 1026
Query: 2408 DSQSCRDKPQPMRSSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKS 2467
Q C + + + ECL + S+ N EL +
Sbjct: 1027 --QRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCEN----------RKNELEQL 1074
Query: 2468 KERSDVEHEQQVTESPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWA 2527
KE EH++ +T+ + A + + + + L
Sbjct: 1075 KEAFAKEHQEFLTKL-AFAEERNQNLMLELETVQQALRS--------------------- 1112
Query: 2528 GVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDER 2587
E+ + N+ G+ K I ++ + + + +D + NE +
Sbjct: 1113 --EMTDNQNNSKSEAGGL-------KQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTK 1163
Query: 2588 YQCYNQEQNDTEGP-KDREKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNVQDISGV 2646
++C N E K+RE + ++ ++ + D+E + + +++ N Q +
Sbjct: 1164 HECQNLESEPIRNSVKERESERNQCNFKPQM----DLEV-----KEISLDSYNAQLVQ-- 1212
Query: 2647 LEAHVHQQSSVDSQISSKENKDLISDATEKVSIAAEDDTLDNTFSEELEKQQQFTEEEDN 2706
LEA + + + Q S KE K+ + + + E L + S+E+ + + +
Sbjct: 1213 LEAML-RNKELKLQESEKE-KECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEE 1270
Query: 2707 LYAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQ-----QLEKISLLTDSLLKV 2761
Y +L T + L+ L++++N+ + ++ Q EK L+T+
Sbjct: 1271 KYISGPHELSTS-----QNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTE----- 1320
Query: 2762 FVKDTVNQ-LQQIKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSE 2820
+ D+ ++ + +K +E +L N+ + +D + +L +++ E
Sbjct: 1321 -LNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIP-----------GGE 1368
Query: 2821 LEDEKEEISSPDMCPRPESPVFGASGQEELAKRLAELELSREFLSALGDDQDWFDEDFGL 2880
++ E + P ES + + ++ EL +FLS + + D+ +
Sbjct: 1369 FGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQM 1428
Query: 2881 SS 2882
SS
Sbjct: 1429 SS 1430
Score = 60.5 bits (145), Expect = 3e-08
Identities = 242/1246 (19%), Positives = 489/1246 (39%), Gaps = 187/1246 (15%)
Query: 1685 RQYMKEEEMRAAHQSSL-LRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQ 1743
+QY+ E E +S+ L + K EK + E LE + L+ +G D L
Sbjct: 1600 KQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGID 1659
Query: 1744 RGLLLRLQQEKAEIKRLQEANKAARKERQLILK------QQE---EIEKIRQTTIKLQEK 1794
++ + E +I + + R + + + QQ+ +IEKI +T ++
Sbjct: 1660 TEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGA-VKPT 1718
Query: 1795 LKSAGESKLDSHSDDDTKDN-KATSPGPTDLETRSPSPIS----ISSSETSSIMQKLKKM 1849
+ +GE D++ + +D + +S ++L P+ + + + E +Q K
Sbjct: 1719 GECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKE 1778
Query: 1850 RSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEE--AEIRQMEK-QALAAWDK---E 1903
S + + L E R + E LL + LD++ E++ M K +A +K E
Sbjct: 1779 TSNENLRLLHVIED----RDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGE 1834
Query: 1904 LIKPKTPKKE-LEDQRTEQKEIASEEESPVPLYSHL--NSESSIPEELGSPAVEY----- 1955
L K + E LE + +E+ E+ L S L +++ S E++G +
Sbjct: 1835 LKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWK 1894
Query: 1956 ------------VPSESIGQEQPG---SPDHSILTEEMICSQELESSTSPSKHSLPKSCT 2000
+ SE E D ++ E +C ++ + L + +
Sbjct: 1895 ERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELS 1954
Query: 2001 SVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDE 2060
V+ + + + G+ K S++ TQ E S QS+ I+ + E
Sbjct: 1955 VVTSERN-----QLRGELDTMSKKTTALDQLSEKMKEKTQ-ELESHQSECLHCIQVAEAE 2008
Query: 2061 LRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKP 2120
++++ ++ L + + K++ QE ++ LE + + T+ EL
Sbjct: 2009 VKEKTELLQTLSSDVSELLKDKTHLQEK--LQSLEKDSQALSLTKCELEN---------- 2056
Query: 2121 QIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSV 2180
QI L+ E +K L + +++ L S+ +L E LS ++ V
Sbjct: 2057 QIAQLNKEKEL-LVKESESLQARLSESDYEKLNVSKALEAALVEKGEFA-LRLSSTQEEV 2114
Query: 2181 SERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSR 2240
+ RV + + R+ + D +EN+ + E N
Sbjct: 2115 HQLRRGIEKLRVRIEADEKKQLHIAEKLKERERE-NDSLKDKVENLERELQMSEENQELV 2173
Query: 2241 ILDMSDGKVGESSKKSEIK---------EIEYTKLKKSK------IEDAFSKEGKSDVLL 2285
ILD + K + K++I+ E++ L+ K I++ + + D LL
Sbjct: 2174 ILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLL 2233
Query: 2286 ---KLVLEQGDSSEILSKKDLPLDSENVQKDLVGL--AIENLHKSEEMLKERQSDQDMNH 2340
K +LE+ + +EI K++ E +Q L L A+ L +E++K + D
Sbjct: 2234 SSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLD--- 2290
Query: 2341 SPNIQSGKDIHEQKNTKEK-----DLSWSEHLFAPKEIPYSEDF------EVSSFKKEIS 2389
P I+ + H+ +N+ EK + + L +++ SE V + ++E+
Sbjct: 2291 -PPIE---EEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLEREL- 2345
Query: 2390 AELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSF--GSNEEISECLSEK-SLSI 2446
E+ + + E ++L ++++ + + + +++ G T G ++ SEK +L+
Sbjct: 2346 -EIARTNQEHAAL-----EAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTN 2399
Query: 2447 HSNVHSDRLLELK----SPTELMKSKERSDVEHEQQVTESPSLASVPTADELFDFHIGDR 2502
+R+ EL+ S +++ KE+ V+ +++ + TA E+ + +
Sbjct: 2400 ELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSS---------TAMEMLQTQLKEL 2450
Query: 2503 VLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQK 2562
N + L E AK E N + + + + + G+
Sbjct: 2451 ----NERVAALHNDQEACKAK-----------EQNLSSQVECLELEKAQLLQGLDEAKNN 2495
Query: 2563 ISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYEKSLPSVND 2622
+ + + + ED +++ + ++ +N + + +S+ E L +
Sbjct: 2496 YIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQN 2555
Query: 2623 IEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKEN--KDLISDATEKVSIA 2680
+E R+L +E + Q I + + Q +++ SS +N +L +K+S
Sbjct: 2556 LEL-----RNLTVELE--QKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSF- 2607
Query: 2681 AEDDTLDNTFSEELEKQQQFTEEEDNLYAEASE--KLCTPLLDLLTREKNQLEAQLKSSL 2738
+EK + T +E L E E + L + L+ EKN+L +L+ L
Sbjct: 2608 -------------VEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLL 2654
Query: 2739 NEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDE---------KIQLSNQELL 2789
E K SK QL++++L L K +Q+++ K R+E + + +Q LL
Sbjct: 2655 EEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALL 2714
Query: 2790 GDDQKKVTPQDLSQNVEEQSPSISGCFLSSELE-----DEKEEISS 2830
D K+ + Q E+ S C S +LE KEE+++
Sbjct: 2715 LDTNKQYEVE--IQTYREKLTSKEECLSSQKLEIDLLKSSKEELNN 2758
Score = 52.8 bits (125), Expect = 5e-06
Identities = 176/962 (18%), Positives = 368/962 (38%), Gaps = 129/962 (13%)
Query: 1330 AAELSYLNAIEESVRQLSD-----VERVRGISLAQQESVSLAQIIKAQQQRHERDLALLK 1384
A E+ +L A ++++Q + E ++ + +Q+ ++ + ++ + + E L L K
Sbjct: 499 AREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQE---TMLRDLQEKINQQENSLTLEK 555
Query: 1385 LKAEQEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARL 1444
LK LE QR + K + H E L + + ++ L A + ++ E L
Sbjct: 556 LKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSA---LELKKKEYEEL 612
Query: 1445 TTDAARQICEMAE----LTRTHISDAVVASGAP-LAILYDHQRQHLPDFVKQLRTRTETD 1499
+ C +E LT+ + S L Q+ ++ +++RT E D
Sbjct: 613 KEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRT-LEMD 671
Query: 1500 RKSPSVSLSQSKEGTLDSKHQKYSASYDSYSE----SSGYKNHDRRSSSGSSRQESPSVP 1555
R++ SV + ++ LDSK + +Y E + ++ + S
Sbjct: 672 RENLSVEI-RNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTG 730
Query: 1556 SCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMT 1615
++ E KL + + + I ++ + D +S+ L KD++ + E + +
Sbjct: 731 QVEDLEHKL--QLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFD 788
Query: 1616 EDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKT-------TLSTAKELNMP 1668
+ SF +++ + + R D S + ++ + +L + K++N
Sbjct: 789 QQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSD 848
Query: 1669 FSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKA--LKEKTKAELAWLEHQKKH 1726
+ + E+ MK E+M HQS + ++ L+E T A HQ
Sbjct: 849 LQKQCEELVQIKGEIEENLMKAEQM---HQSFVAETSQRISKLQEDTSA------HQNVV 899
Query: 1727 LRDKGEDDKMPPLRKKQRGLLL---RLQQEKAEIKRLQEANKAARKERQLILKQQEEIEK 1783
+ + L K++ L L +++ E+AEI+ L+++N L+ +E++
Sbjct: 900 A------ETLSALENKEKELQLLNDKVETEQAEIQELKKSN-------HLLEDSLKELQL 946
Query: 1784 IRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIM 1843
+ +T + L++K S+ S ++ T++N L + E +++
Sbjct: 947 LSET-LSLEKKEMSSIISLNKREIEELTQENGTLKEINASL-----------NQEKMNLI 994
Query: 1844 QKLKKMRSRMDEKFLTKREQKLMQRR-QHAEELLEWKRRLDAEEAEIRQMEKQALAAWDK 1902
QK + + +DE RE+ + + Q+ +E L +R + + ++ AA +K
Sbjct: 995 QKSESFANYIDE-----REKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEK 1049
Query: 1903 ELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIG 1962
+LE E + + N + E E++ +
Sbjct: 1050 N--------SKLECLLNECTSLCENRK---------NELEQLKEAFAKEHQEFLTKLAFA 1092
Query: 1963 QEQPGSPDHSILTEEMICSQELESSTSPSKHSLP--KSCTSVSKQESSKGSHRTGG---- 2016
+E+ + + T + E+ + + SK K K+E +K
Sbjct: 1093 EERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQE 1152
Query: 2017 --QCHLPIKSHQHCYSWSDESL--SMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLK 2072
Q +K+ C + E + S+ + E+ +Q + + ++ E+ ++
Sbjct: 1153 NEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQ 1212
Query: 2073 KEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASE-- 2130
E R KE LK QE+ E E ++ + DLETS Q + +S +
Sbjct: 1213 LEAMLRNKE-LKLQES------EKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCE 1265
Query: 2131 -KPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYA 2189
+ K ++ H T++N + H+ SL + ++E
Sbjct: 1266 IDAEEKYISGPHELSTSQNDNA----------------HLQCSLQTTMNKLNELEKICEI 1309
Query: 2190 KRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKV 2249
+ +++ TE + S + ++RK+ EE G L V L+ L + D+ G+
Sbjct: 1310 LQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEF 1369
Query: 2250 GE 2251
GE
Sbjct: 1370 GE 1371
Score = 34.3 bits (77), Expect = 2.0
Identities = 41/201 (20%), Positives = 89/201 (44%), Gaps = 21/201 (10%)
Query: 2590 CYNQEQNDTEGPKDREKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNVQD-ISGVLE 2648
C +++Q + EG K RE +++EY ++ ++ ++E ++ ++ E
Sbjct: 2680 CMHKDQVEKEG-KVRE-EIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEE 2737
Query: 2649 AHVHQQSSVDSQISSKENKDLISDATEKVSIAAEDDTLDNT-FSEELEKQQQFTEEEDNL 2707
Q+ +D SSKE + AT ++ + +DN + +L+K+ N
Sbjct: 2738 CLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKE--------NE 2789
Query: 2708 YAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTV 2767
A+ KL L EK L+ +L ++K K T +++ V +
Sbjct: 2790 RAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQK---------TGTVMDTKVDELT 2840
Query: 2768 NQLQQIKKTRDEKIQLSNQEL 2788
+++++K+T +EK + +++ L
Sbjct: 2841 TEIKELKETLEEKTKEADEYL 2861
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 81.3 bits (199), Expect = 1e-14
Identities = 145/732 (19%), Positives = 297/732 (40%), Gaps = 82/732 (11%)
Query: 1558 KENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTE- 1616
+ NE +LN +++ES I E D+ +S L D + + + E +K E T+
Sbjct: 1276 ERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMK--ELQTQY 1333
Query: 1617 DEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSF 1676
D +++Q + R + G DD D +E++ Q F
Sbjct: 1334 DALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEF 1393
Query: 1677 SKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKE-KTKAELAWLEHQKKHLRDKGEDDK 1735
+E+ +Q ++ E R + ++AL++ K K + E Q L +G+ +
Sbjct: 1394 ED-KLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVR 1452
Query: 1736 MPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEK- 1794
L KKQR L Q E +R + + ++E+ ++L + +++ +L+EK
Sbjct: 1453 NHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQ------QLEEKD 1506
Query: 1795 LKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMD 1854
+ AG ++ + + +D IS S+ + + K+KK ++
Sbjct: 1507 MDIAGFTQKVVSLEAELQD------------------ISSQESKDEASLAKVKKQLRDLE 1548
Query: 1855 EKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKEL 1914
K + +E++L ++ + L + K RL+ E +RQ + + + D+E+ + + ++
Sbjct: 1549 AK-VKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKK 1607
Query: 1915 EDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPD---- 1970
Q Q E E++ V L + + +L + + + V E+ D
Sbjct: 1608 LKQMEVQLEEEYEDKQKV-----LREKRELEGKLATLS-DQVNRRDFESEKRLRKDLKRT 1661
Query: 1971 HSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQE--------SSKGSHRTGGQCHLPI 2022
++L + + L++S +PSK + + + + E + K HL I
Sbjct: 1662 KALLADAQLMLDHLKNS-APSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQI 1720
Query: 2023 KSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVV----------NQLK 2072
+ +E LS Q E Q+ +E + + ++K K+ V N L+
Sbjct: 1721 DDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQ 1780
Query: 2073 KEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKP 2132
+ ++ KE+ + QE ++ L+S EF++++ + S L + AK + E+
Sbjct: 1781 AQLEEANKEKQELQEK--LQALQSQVEFLEQSMVDKS--LVSRQEAKIRELETRLEFERT 1836
Query: 2133 KIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSE------RSLS 2186
++K L L S +N + LTE R + E+ + + L R E R +
Sbjct: 1837 QVKRLESL-ASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEA 1895
Query: 2187 AYAKRVNEWDSRTEDFQTPSPVLRSSRKIR-----------EESGDSLENVPALHLLKEL 2235
+++ +E + E + + L++ K+ E+ +S EN ++ +
Sbjct: 1896 EASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSEGDS 1955
Query: 2236 NATSRILDMSDG 2247
+ S + D DG
Sbjct: 1956 DVDSELEDRVDG 1967
Score = 48.9 bits (115), Expect = 8e-05
Identities = 101/525 (19%), Positives = 212/525 (40%), Gaps = 47/525 (8%)
Query: 1328 RMAAELSYLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDL------- 1380
R +ELS A EE+ R E+++ L +++ + LA+ +QQ E+D+
Sbjct: 1462 RFDSELS--QAHEEAQR-----EKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQ 1514
Query: 1381 ALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSE 1440
++ L+AE + + SQ +E + L+ V+ Q E + Q T ++ Q
Sbjct: 1515 KVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDE-QAGTIQMLEQAKL 1573
Query: 1441 TARLTTDAARQI-CEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETD 1499
+ + RQ + E + +A + L + + D K LR + E +
Sbjct: 1574 RLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELE 1633
Query: 1500 RKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKE 1559
K ++S ++ K + + D +S S++E + + E
Sbjct: 1634 GKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLE 1693
Query: 1560 NEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYS-LKFDESMTEDE 1618
+ +++ +V+ D L+ D + K T++ + S L+ +++ ++
Sbjct: 1694 ESEFTCAAAVKARKAMEVE-IEDLHLQIDDI-----AKAKTALEEQLSRLQREKNEIQNR 1747
Query: 1619 IEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSK 1678
+EE + H+ + R +D +A E+ +EL Q
Sbjct: 1748 LEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEAN-KEKQELQEKLQALQSQ--- 1803
Query: 1679 FTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAE-LAWLEHQKKHLRDK--GEDDK 1735
+E + Q M ++ + + ++ + L + E+T+ + L L + K +K E D+
Sbjct: 1804 --VEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQ 1861
Query: 1736 MPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQE---EIEKIRQTTIKLQ 1792
+++ RLQ++ + K +E + ARKE + K+ E ++E + LQ
Sbjct: 1862 RIAAENREKEQNKRLQRQLRDTK--EEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919
Query: 1793 EKLK----------SAGESKLDSHSDDDTKDNKATSPGPTDLETR 1827
LK +A E +++S ++D +++ S ++LE R
Sbjct: 1920 ADLKLAFKRIGDLQAAIEDEMESDENEDLINSEGDSDVDSELEDR 1964
Score = 33.1 bits (74), Expect = 4.4
Identities = 89/420 (21%), Positives = 170/420 (40%), Gaps = 76/420 (18%)
Query: 2054 IRALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDLE 2113
++ ++++R + + QL+ + +K +KER + + S +LES I + +EL+ +
Sbjct: 1249 VQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNS--DRLESR---ISELTSELTDERN 1303
Query: 2114 TSPTAKPQIKTLSSASEKPKIKPLTPLH-RSETAKNWKSLTESERSRGSLESIAE---HV 2169
T +A Q+ +A K + L + + K + E E L AE V
Sbjct: 1304 TGESAS-QLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEV 1362
Query: 2170 DASLSGSERSV----SERSLSAYAKRV-NEWDSRTEDFQTPSPVLRSSRKIREESGDSLE 2224
D +G E + + R + KR+ E++ + E Q L R++ + DS E
Sbjct: 1363 DDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQL--ERRLGDLQADSEE 1420
Query: 2225 NVPALHLLK--------ELNATSRILD--------------MSDGKVGESSKKSEIKEIE 2262
+ AL LK EL T L+ D ++ ++ ++++ ++++
Sbjct: 1421 SQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQ 1480
Query: 2263 YTKLKKSK---IEDAFSKE-----------GKSDVLLKLVLEQGDSSEILSKKDLPL--- 2305
KL++ K + +AFS + G + ++ L E D S SK + L
Sbjct: 1481 REKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKV 1540
Query: 2306 ------------DSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQS-GKDIHE 2352
D E + G I+ L +++ L+ HS ++S +++ E
Sbjct: 1541 KKQLRDLEAKVKDQEEELDEQAG-TIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEE 1599
Query: 2353 QKNTKEKDLSWS----EHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKD 2408
+ + +K L E + K+ E E+ +S ++ + DFE S LRKD
Sbjct: 1600 ARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFE--SEKRLRKD 1657
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 80.9 bits (198), Expect = 2e-14
Identities = 146/745 (19%), Positives = 305/745 (40%), Gaps = 84/745 (11%)
Query: 1558 KENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTE- 1616
+ NE +LN +++ES I E D+ +S L D + + + E +K E T+
Sbjct: 1276 ERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMK--ELQTQY 1333
Query: 1617 DEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSF 1676
D +++Q + R + G DD D +E++ Q F
Sbjct: 1334 DALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEF 1393
Query: 1677 SKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKE-KTKAELAWLEHQKKHLRDKGEDDK 1735
+E+ +Q ++ E R + ++AL++ K K + E Q L +G+ +
Sbjct: 1394 ED-KLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVR 1452
Query: 1736 MPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEK- 1794
L KKQR L Q E +R + + ++E+ ++L + +++ +L+EK
Sbjct: 1453 NHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQ------QLEEKD 1506
Query: 1795 LKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMD 1854
+ AG ++ + + +D IS S+ + + K+KK ++
Sbjct: 1507 MDIAGFTQKVVSLEAELQD------------------ISSQESKDEASLAKVKKQLRDLE 1548
Query: 1855 EKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKEL 1914
K + +E++L ++ + L + K RL+ E +RQ + + + D+E+ + + ++
Sbjct: 1549 AK-VKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKK 1607
Query: 1915 EDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPD---- 1970
Q Q E E++ V L + + +L + + + V E+ D
Sbjct: 1608 LKQMEVQLEEEYEDKQKV-----LREKRELEGKLATLS-DQVNRRDFESEKRLRKDLKRT 1661
Query: 1971 HSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQE--------SSKGSHRTGGQCHLPI 2022
++L + + L++S +PSK + + + + E + K HL I
Sbjct: 1662 KALLADAQLMLDHLKNS-APSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQI 1720
Query: 2023 KSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVV----------NQLK 2072
+ +E LS Q E Q+ +E + + ++K K+ V N L+
Sbjct: 1721 DDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQ 1780
Query: 2073 KEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKP 2132
+ ++ KE+ + QE ++ L+S EF++++ + S L + AK + E+
Sbjct: 1781 AQLEEANKEKQELQEK--LQALQSQVEFLEQSMVDKS--LVSRQEAKIRELETRLEFERT 1836
Query: 2133 KIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSE------RSLS 2186
++K L L S +N + LTE R + E+ + + L R E R +
Sbjct: 1837 QVKRLESL-ASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEA 1895
Query: 2187 AYAKRVNEWDSRTEDFQTPSPVLRSSRKIR-----------EESGDSLENVPALHLLKEL 2235
+++ +E + E + + L++ K+ E+ +S EN ++ L+++
Sbjct: 1896 EASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDM 1955
Query: 2236 NATSRILDMSDGKVGESSKKSEIKE 2260
++ + G+S SE+++
Sbjct: 1956 --VTKYQKRKNKLEGDSDVDSELED 1978
Score = 46.2 bits (108), Expect = 5e-04
Identities = 117/622 (18%), Positives = 243/622 (39%), Gaps = 58/622 (9%)
Query: 1328 RMAAELSYLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDL------- 1380
R +ELS A EE+ R E+++ L +++ + LA+ +QQ E+D+
Sbjct: 1462 RFDSELS--QAHEEAQR-----EKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQ 1514
Query: 1381 ALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSE 1440
++ L+AE + + SQ +E + L+ V+ Q E + Q T ++ Q
Sbjct: 1515 KVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDE-QAGTIQMLEQAKL 1573
Query: 1441 TARLTTDAARQI-CEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETD 1499
+ + RQ + E + +A + L + + D K LR + E +
Sbjct: 1574 RLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELE 1633
Query: 1500 RKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKE 1559
K ++S ++ K + + D +S S++E + + E
Sbjct: 1634 GKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLE 1693
Query: 1560 NEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYS-LKFDESMTEDE 1618
+ +++ +V+ D L+ D + K T++ + S L+ +++ ++
Sbjct: 1694 ESEFTCAAAVKARKAMEVE-IEDLHLQIDDI-----AKAKTALEEQLSRLQREKNEIQNR 1747
Query: 1619 IEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSK 1678
+EE + H+ + R +D +A E+ +EL Q
Sbjct: 1748 LEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEAN-KEKQELQEKLQALQSQ--- 1803
Query: 1679 FTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPP 1738
+E + Q M ++ + + ++ + L + E+T+ + LE L+ + M
Sbjct: 1804 --VEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKR--LESLASRLK-----ENMEK 1854
Query: 1739 LRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSA 1798
L +++ + +EK + KRLQ + ++E + +++ E + + E L++A
Sbjct: 1855 LTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAA 1914
Query: 1799 GESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFL 1858
+S D K DL+ + S E ++ L+ M ++
Sbjct: 1915 NQSL--------QADLKLAFKRIGDLQAAIED--EMESDENEDLINSLQDMVTKYQ---- 1960
Query: 1859 TKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPK---KELE 1915
KR+ KL EL + R+D ++ + + + + AA D +K +P K L
Sbjct: 1961 -KRKNKLEGDSDVDSEL---EDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLA 2016
Query: 1916 DQRTEQKEIASEEESPVPLYSH 1937
R++ + + S P YSH
Sbjct: 2017 PDRSDDEHDPLDNTSR-PRYSH 2037
Score = 37.4 bits (85), Expect = 0.23
Identities = 169/824 (20%), Positives = 325/824 (39%), Gaps = 134/824 (16%)
Query: 2054 IRALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDLE 2113
++ ++++R + + QL+ + +K +KER + + S +LES I + +EL+ +
Sbjct: 1249 VQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNS--DRLESR---ISELTSELTDERN 1303
Query: 2114 TSPTAKPQIKTLSSASEKPKIKPLTPLH-RSETAKNWKSLTESERSRGSLESIAE---HV 2169
T +A Q+ +A K + L + + K + E E L AE V
Sbjct: 1304 TGESAS-QLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEV 1362
Query: 2170 DASLSGSERSV----SERSLSAYAKRV-NEWDSRTEDFQTPSPVLRSSRKIREESGDSLE 2224
D +G E + + R + KR+ E++ + E Q L R++ + DS E
Sbjct: 1363 DDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQL--ERRLGDLQADSEE 1420
Query: 2225 NVPALHLLK--------ELNATSRILD--------------MSDGKVGESSKKSEIKEIE 2262
+ AL LK EL T L+ D ++ ++ ++++ ++++
Sbjct: 1421 SQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQ 1480
Query: 2263 YTKLKKSK---IEDAFSKE-----------GKSDVLLKLVLEQGDSSEILSKKDLPLDSE 2308
KL++ K + +AFS + G + ++ L E D S SK + L
Sbjct: 1481 REKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASL--A 1538
Query: 2309 NVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLF 2368
V+K L L + + EE L E+ M ++ ++ + T K++
Sbjct: 1539 KVKKQLRDLEAK-VKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEME------ 1591
Query: 2369 APKEIPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATS 2428
S D EV ++ +L EV + R+K + + +
Sbjct: 1592 -------SRDEEVEEARQSCQKKL--KQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQ 1642
Query: 2429 FGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESP-SLAS 2487
+ SE K L + +D L L SK R + + Q+ ES + A+
Sbjct: 1643 VNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSK-REIAQLKNQLEESEFTCAA 1701
Query: 2488 VPTADELFDFHIGD-RVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIA 2546
A + + I D + I ++ K +T+ + + ++ +K E N D
Sbjct: 1702 AVKARKAMEVEIEDLHLQIDDIA------KAKTALEEQL-SRLQREKNEIQNRLEEDQED 1754
Query: 2547 YFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREK 2606
E +KH + + + D IN D +E + + Q + + + +
Sbjct: 1755 MNELMKKHK--------AAVAQASRDLAQIN-DLQAQLEEANKEKQELQEKLQALQSQVE 1805
Query: 2607 DVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKEN 2666
+ + +KSL V+ EA + R ++E + Q V + S+ S++ KEN
Sbjct: 1806 FLEQSMVDKSL--VSRQEAKI-RELETRLEFERTQ---------VKRLESLASRL--KEN 1851
Query: 2667 KDLISDATEKVSIAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTRE 2726
+ +++ ++ IAAE+ + ++ L++Q + T+EE A + +R+
Sbjct: 1852 MEKLTEERDQ-RIAAENREKEQ--NKRLQRQLRDTKEEMGELARKEAE--------ASRK 1900
Query: 2727 KNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQ 2786
K++LE L+ SL +S Q K++ L+ ++D + DE N+
Sbjct: 1901 KHELEMDLE-SLEAANQSLQADLKLAFKRIGDLQAAIEDEMES--------DE-----NE 1946
Query: 2787 ELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDEKEEISS 2830
+L+ Q VT +N E + SELED + + S
Sbjct: 1947 DLINSLQDMVTKYQKRKNKLEGDSDV-----DSELEDRVDGVKS 1985
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 79.0 bits (193), Expect = 7e-14
Identities = 177/907 (19%), Positives = 341/907 (37%), Gaps = 125/907 (13%)
Query: 1436 AQQSETARLTTDAARQICEMAELTR-THISDA---VVASGAPLAILYDHQRQHLPDFVKQ 1491
++QSET +D+ + + E++R +H S + + LYD + Q D +
Sbjct: 681 SKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGK 740
Query: 1492 LRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQES 1551
+ ++ T +S + ++ SK ++ + S S +S K S G++R
Sbjct: 741 RKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTK 800
Query: 1552 PSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFD 1611
+P+ K+ + + + + +D Q +L++ S D
Sbjct: 801 KRIPNTKDFDSSEDEKHSKKGMDNQ----GHKNLKTSQEGSSDD---------------- 840
Query: 1612 ESMTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSG 1671
E + E ++F S + ME R + P+K S + + SG
Sbjct: 841 ---AERKQERETFSSAEGTVDKDTTIMELR---------DRLPKKQQASASTDGVDKLSG 888
Query: 1672 GQDSFSKFTMEMVRQ------YMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKK 1725
+ SF+ + V + ++K + + Q L + EK LK+ E + E KK
Sbjct: 889 KEQSFTSLEVRKVAETKEKSKHLKTKTCKKV-QDGLSDIAEKFLKKDQSDETS--EDDKK 945
Query: 1726 HLRDKGEDDKMPPLRKKQRGLLLRLQQEKA--------EIKRLQEANKAARKERQLILKQ 1777
+ KG ++K P K++ + + Q E + E + + K ++ +
Sbjct: 946 QSK-KGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDG 1004
Query: 1778 QEEIEKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETR--------SP 1829
+++ +KIR T K +++L E D+ ++K + G E + S
Sbjct: 1005 EKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSR 1064
Query: 1830 SPISISSSETSSIMQKLKKMRSRMDE-KFLTKREQKLMQRRQHAEELLEWKRRLDAEE-A 1887
SSS+T K S K + RE++ + +++ +E+ DAEE +
Sbjct: 1065 KRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESS 1124
Query: 1888 EIRQMEKQALAAWDKELIKPKTPKKELE-DQRTEQKEIASEEESPVPLYSHLN-SESSIP 1945
E + +KQ ++ K +I + + L + +Q +I S S + + E S
Sbjct: 1125 EDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSD 1184
Query: 1946 EELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPS------------KH 1993
E+ P E + S S D ++ + + + P K
Sbjct: 1185 EQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKA 1244
Query: 1994 SLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEG- 2052
+L S E +G RTG Q +E+ + SE+ SD + +
Sbjct: 1245 NLSSDEDGSSDDEPEEGKKRTGKQ--------NEENPGDEEAKNQVNSESDSDSEESKKP 1296
Query: 2053 --RIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQ 2110
R R L+ +L + KK + K KE +K + +K +E S+
Sbjct: 1297 RYRHRLLRHKLTVSDGESGEEKKTKPKEHKE-VKGRNR-------------RKVSSEDSE 1342
Query: 2111 DLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVD 2170
D + + + + S ++P+ + E +++K + R + +S +E
Sbjct: 1343 DSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSE--- 1399
Query: 2171 ASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALH 2230
+ S SE E+ + E + E+ + SP + +KIR+ D +
Sbjct: 1400 -NKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPG-KGRKKIRKILKDDKLRTETQN 1457
Query: 2231 LLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKK-SKIEDAFSKEGKSDVLLKLVL 2289
LKE E K+ +E E KL++ +IEDA K + KLVL
Sbjct: 1458 ALKEEE--------------ERRKRIAEREREREKLREVIEIEDA--SPTKCPITTKLVL 1501
Query: 2290 EQGDSSE 2296
++ + ++
Sbjct: 1502 DEDEETK 1508
Score = 68.9 bits (167), Expect = 7e-11
Identities = 258/1434 (17%), Positives = 536/1434 (37%), Gaps = 216/1434 (15%)
Query: 1411 ESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELTRTHISDAVVAS 1470
E+L+Q++Q ++ +V E + K+ T+R + C E + D+ S
Sbjct: 247 ENLEQLLQQNKKKIKVDSEKSNKV---YEHTSRFSPKKTSSNCNGEE---KKLDDSCSGS 300
Query: 1471 GAPLAILYDHQRQHLP-DFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSY 1529
+ Y + +P + +K+ + ET S + K+ T +S+ +S
Sbjct: 301 -----VTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSE----ISSATKL 351
Query: 1530 SESSGYKN--HDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRS 1587
+ +K+ D + + + ++ S + K K ID + +T A R
Sbjct: 352 RQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKA----RK 407
Query: 1588 DSVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDD 1647
P ++KD + K + ++ +++ + +P+E R + G H
Sbjct: 408 GEKPCALEKKDIS--------KSEAKLSRKQVDSEHMHQNVPTEEQR--TNKSTGGEHKK 457
Query: 1648 SDEEASPEKTTLSTAKELNM-----PFSGGQDSFSKFTMEMVRQYMKEE--------EMR 1694
SD + P+ +T+++L+M P S +D F M Q + E
Sbjct: 458 SDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQE 517
Query: 1695 AAHQSSLLRLREK----ALKEKTKAELAWLEHQK------KHLRDKGEDDKMPPLRK--- 1741
S L + K +K KT A++ + K + KG D + P K
Sbjct: 518 VESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGY 577
Query: 1742 KQRGLLLRLQ-----QEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLK 1796
K GL +L+ QE ++ + L E E L+L EE + R +K +
Sbjct: 578 KSCGLNPKLEKCGLGQENSDNEHLVE------NEVSLLL---EESDLRRSPRVKTTPLRR 628
Query: 1797 SAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEK 1856
+ + S+SD++ + ++ + S+ + K R+ D
Sbjct: 629 PTETNPVTSNSDEECNE-------------------TVKEKQKLSVPVRKKDKRNSSDSA 669
Query: 1857 FLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQA-LAAWDKELIKPKTPKKELE 1915
+ KL + +Q E ++ D A ++++ + + ++ D ++ + T K L
Sbjct: 670 IDNPKPNKLPKSKQ--SETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLY 727
Query: 1916 DQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILT 1975
D +T+ A +++ S S + G A + S+ Q Q S ++
Sbjct: 728 DLKTQ----AGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSEL 783
Query: 1976 EEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDES 2035
E+ I S + +K +P + S ++ Q H +K+ Q SD++
Sbjct: 784 EKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQE--GSSDDA 841
Query: 2036 LSMTQSETTSDQS---DIEGRIRALKDELRKRKSVVNQLKKEQKKRQKER-LKAQEASLI 2091
+ ET S D + I L+D L K++ K KE+ + E +
Sbjct: 842 ERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKV 901
Query: 2092 KQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKS 2151
+ + + +K + QD LS +EK K + + K K
Sbjct: 902 AETKEKSKHLKTKTCKKVQD------------GLSDIAEKFLKKDQSDETSEDDKKQSKK 949
Query: 2152 LTESERSRGSLES----IAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSP 2207
TE ++ + + + ++S G+E+ + + K + + + T D +
Sbjct: 950 GTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGE---- 1005
Query: 2208 VLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLK 2267
+ S+KIR+++ K+ + S + S GK G+S SE K
Sbjct: 1006 --KKSKKIRDKTS------------KKKDELSDYAEKSTGK-GDSCDSSEDK-------- 1042
Query: 2268 KSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGLAIENLHKSEE 2327
KSK A+ +E K KL+ + + S D + ++++D + + L + E
Sbjct: 1043 KSK-NGAYGREKKR---CKLLGKSSRKRQDCSSSDT--EKYSMKEDGCNSSDKRLKRIE- 1095
Query: 2328 MLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSEDFEVSSFKKE 2387
L+ER++ ++ IQSG + + + E + + + K+ ++ + +S +
Sbjct: 1096 -LRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRT- 1153
Query: 2388 ISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEISECLSEKSLSIH 2447
S + + D SS + D Q+ S G++ + ++E L S +
Sbjct: 1154 -STKRKQADITSSSSSDIEDDDQN---------SIGEGSSDEQKIKPVTENLVLSSHTGF 1203
Query: 2448 SNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESPSLASVP---TADELFDFHIGDRVL 2504
D L P + + D + E ++ + L + ++DE D D
Sbjct: 1204 CQSSGDEALSKSVPVTV--DDDDDDNDPENRIAKKMLLEEIKANLSSDE--DGSSDDEPE 1259
Query: 2505 IGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKIS 2564
G + G + G E K + N+ D + + +H + +S
Sbjct: 1260 EGKKRTGKQNEENP---------GDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVS 1310
Query: 2565 HIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYEKSLPSVNDIE 2624
+ E ++ R + +++ D++ +E VSE E +
Sbjct: 1311 DGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDF---QESGVSEEVSESE-------D 1360
Query: 2625 ASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKENKDLISDATEKVSIAAEDD 2684
R+RS K +A + + Q + + D++ + +E++
Sbjct: 1361 EQRPRTRSAK-------------KAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEE 1407
Query: 2685 TLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKS 2744
+ EE E++++ EE++N +++ K + +L +K + E Q ++L EE++
Sbjct: 1408 EEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQ--NALKEEEER 1465
Query: 2745 KQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKVTP 2798
++++ + + L +V +I+ K ++ + +L +D++ P
Sbjct: 1466 RKRIAEREREREKLREVI---------EIEDASPTKCPITTKLVLDEDEETKEP 1510
Score = 59.3 bits (142), Expect = 6e-08
Identities = 147/738 (19%), Positives = 287/738 (38%), Gaps = 122/738 (16%)
Query: 49 EVAPTSTAVCDSVMDTKKSSTSATRKISRKDGRYLDDSWVNAPISKSTKSRKEKSRSPLR 108
E P ++ + +T K + + +KD R DS ++ P K K K K +
Sbjct: 631 ETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNP--KPNKLPKSK-----Q 683
Query: 109 ATTLESNVKKNNRVEFREPLVSYREIHGAPSNFSSSHLESKHVYCVDVNEEKTESGNWMI 168
+ T++ N + + + + R H + S+ + + + H D+ KT++G
Sbjct: 684 SETVDQNSDSDEMLAILKEVS--RMSHSSSSDTDINEIHTNHKTLYDL---KTQAGKDDK 738
Query: 169 GSREERNIRS-CDFE-----SSQSSVINDTVVRFLNDRPAIDALQNSEC--LIRMGASMR 220
G R+ ++ S DF+ S++SS+I+ + ++ D+ E + ++GA+
Sbjct: 739 GKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAART 798
Query: 221 TEEEMPNRT------------KGSEN----NLKLSVNNMAHDTDPKALRLTDSSPSSTST 264
T++ +PN KG +N NLK S + D + K R T SS T
Sbjct: 799 TKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVD 858
Query: 265 SNSQRLDILKRRQHDVKLEKLKERIRKQWEHSEETNGRGQKLGHIDHPVMVVNVDNSVTA 324
D + +L++R+ K+ + S T+G + G + S T+
Sbjct: 859 K-------------DTTIMELRDRLPKKQQASASTDGVDKLSGK----------EQSFTS 895
Query: 325 -KVRKVATAPPAPAYKGFNPSETKIRTPDGKVWQEAEFQNMSRELYRDLALHFADDISIK 383
+VRKVA + ++T K Q+ + L +D + ++D +
Sbjct: 896 LEVRKVAETKEKSKH---------LKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQ 946
Query: 384 EKPA--EKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHLISTSSWRDGQKLVKKILGPAP 441
K EK K K V K+++ + SS G+ L K +K+I
Sbjct: 947 SKKGTEEKKKPSDFKKKVIKMEQQYESSSD----GTEKLPEREEICHFPKGIKQIKNGTT 1002
Query: 442 RMEPKEQRTASSDRGGRERTAKSGGHI--------GRAES-DPRLDVLHRHLQRNSERSR 492
E K ++ R++T+K + G+ +S D D ++ E+ R
Sbjct: 1003 DGEKKSKKI-------RDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKR 1055
Query: 493 SKSRSENNIKKLASSLPDN-----KQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQD 547
K +++ K+ S D K++ + +K IE+R + ++K++
Sbjct: 1056 CKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELR--------ERRNLSSKRN 1107
Query: 548 TVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYD----TDEVRQYIVRQ 603
T E+Q+ SS+ A S K+K + ++ + ++ +++ T + I
Sbjct: 1108 TKEIQSGSSSSD--AEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSS 1165
Query: 604 QEERKRKQNEEKKAQKEATEQKNKRLQE----------LYRKQKEAFTKVKNVPPSEPSA 653
++ + + EQK K + E EA +K V +
Sbjct: 1166 SSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDD 1225
Query: 654 TRRLQETYSK-LLLEKTLLEEPSHQHVTQETQAKPGYQPSGESDKENKVQERPPS-ASSS 711
+ +K +LLE+ S + + + + + G + +G+ ++EN E + +S
Sbjct: 1226 DNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSE 1285
Query: 712 SDMSLSEPPQPLARKDLM 729
SD E +P R L+
Sbjct: 1286 SDSDSEESKKPRYRHRLL 1303
Score = 43.5 bits (101), Expect = 0.003
Identities = 200/1087 (18%), Positives = 394/1087 (36%), Gaps = 125/1087 (11%)
Query: 1134 PQEDHSNRKSAYD-PSSVDVTSQHSSGAQSAASSRS---STSSKGKKG--------KKEK 1181
P++ N ++A + SSVD SSG + S S + SSK +G K K
Sbjct: 487 PEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTK 546
Query: 1182 TEWLDSFTGNVQNSLL---DEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTDSTLEDLSG 1238
++ ++ NS + D ++ + K G + KL Q + L +
Sbjct: 547 ELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEV 606
Query: 1239 HSVSVSSDKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTD 1298
+ SD RS + T+PL ++ + V S E +V K + P+
Sbjct: 607 SLLLEESDLRRSPRVKTTPLRRPTETN---PVTSNSDEECNETVKEKQ----KLSVPVRK 659
Query: 1299 LNPA-ASRTTTENMAP--IPGSKRFSPAGLHHRMAAELSYLNAIEESVRQLSDVERVRGI 1355
+ +S + +N P +P SK+ + L+ L + S + I
Sbjct: 660 KDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEI 719
Query: 1356 SLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQ 1415
+ L K Q + ++ K ++++ S + + K+A+
Sbjct: 720 HTNHKTLYDL----KTQAGKDDKG------KRKRKSSTSGSDFDTKKGKSAK------SS 763
Query: 1416 VVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELTRTHISDAVVASGAPLA 1475
++ ++ T QSE++ ++ ++I M+++ + + +
Sbjct: 764 IISKKKRQT-------------QSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFD 810
Query: 1476 ILYD--HQRQHLPDFV-KQLRTRTE-----TDRKSPSVSLSQSKEGTLDS---------- 1517
D H ++ + + K L+T E +RK + S S EGT+D
Sbjct: 811 SSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFS-SAEGTVDKDTTIMELRDR 869
Query: 1518 --KHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDE 1575
K Q+ SAS D + SG + E V KE K L K + +
Sbjct: 870 LPKKQQASASTDGVDKLSG-------KEQSFTSLEVRKVAETKEKSKHLK-TKTCKKVQD 921
Query: 1576 QVQTAADDSLRSD-SVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRS-------L 1627
+ A+ L+ D S + D+K + TE K + + EQ + S L
Sbjct: 922 GLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKL 981
Query: 1628 LPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMVRQY 1687
E F ++ + +D E +K T+K+ + + S K +
Sbjct: 982 PEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED 1041
Query: 1688 MKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKG---EDDKMPPLRKKQR 1744
K + + +L K+ +++ + + +K +++ G D ++ + ++R
Sbjct: 1042 KKSKNGAYGREKKRCKLLGKSSRKRQDCSSS--DTEKYSMKEDGCNSSDKRLKRIELRER 1099
Query: 1745 GLLLRLQQEK--------AEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLK 1796
L + K ++ + E NK +K+R K+ +++ ++ +++ K K
Sbjct: 1100 RNLSSKRNTKEIQSGSSSSDAEESSEDNKK-KKQRTSSKKKAVIVKEKKRNSLRTSTKRK 1158
Query: 1797 SAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPIS---ISSSETSSIMQKLKKMRSRM 1853
A + S S D +D+ S G + + P++ + SS T + S+
Sbjct: 1159 QAD---ITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKS 1215
Query: 1854 DEKFLTKREQKLMQRRQHAEELL--EWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPK 1911
+ + + A+++L E K L ++E E + + +
Sbjct: 1216 VPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGD 1275
Query: 1912 KELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDH 1971
+E ++Q + + + EES P Y H + G E +E G
Sbjct: 1276 EEAKNQVNSESD-SDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRR 1334
Query: 1972 SILTEEMICSQELESSTSPS---KHSLPKSCTSVSKQESSKGSHRTGGQC--HLPIKSHQ 2026
+ +E+ S ES S + T +K+ + + R+ Q IK +
Sbjct: 1335 KVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQE 1394
Query: 2027 HCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQ 2086
S + + + E ++ + E +DE KS KK +K + ++L+ +
Sbjct: 1395 DSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTE 1454
Query: 2087 EASLIKQLESYDEFIKKTEAELSQDLET------SPTAKPQIKTLSSASEKPKIKPLTPL 2140
+ +K+ E + I + E E + E SPT P L ++ +PL +
Sbjct: 1455 TQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQV 1514
Query: 2141 HRSETAK 2147
HR+ K
Sbjct: 1515 HRNMVIK 1521
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 79.0 bits (193), Expect = 7e-14
Identities = 177/907 (19%), Positives = 341/907 (37%), Gaps = 125/907 (13%)
Query: 1436 AQQSETARLTTDAARQICEMAELTR-THISDA---VVASGAPLAILYDHQRQHLPDFVKQ 1491
++QSET +D+ + + E++R +H S + + LYD + Q D +
Sbjct: 719 SKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGK 778
Query: 1492 LRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQES 1551
+ ++ T +S + ++ SK ++ + S S +S K S G++R
Sbjct: 779 RKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTK 838
Query: 1552 PSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFD 1611
+P+ K+ + + + + +D Q +L++ S D
Sbjct: 839 KRIPNTKDFDSSEDEKHSKKGMDNQ----GHKNLKTSQEGSSDD---------------- 878
Query: 1612 ESMTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSG 1671
E + E ++F S + ME R + P+K S + + SG
Sbjct: 879 ---AERKQERETFSSAEGTVDKDTTIMELR---------DRLPKKQQASASTDGVDKLSG 926
Query: 1672 GQDSFSKFTMEMVRQ------YMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKK 1725
+ SF+ + V + ++K + + Q L + EK LK+ E + E KK
Sbjct: 927 KEQSFTSLEVRKVAETKEKSKHLKTKTCKKV-QDGLSDIAEKFLKKDQSDETS--EDDKK 983
Query: 1726 HLRDKGEDDKMPPLRKKQRGLLLRLQQEKA--------EIKRLQEANKAARKERQLILKQ 1777
+ KG ++K P K++ + + Q E + E + + K ++ +
Sbjct: 984 QSK-KGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDG 1042
Query: 1778 QEEIEKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETR--------SP 1829
+++ +KIR T K +++L E D+ ++K + G E + S
Sbjct: 1043 EKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSR 1102
Query: 1830 SPISISSSETSSIMQKLKKMRSRMDE-KFLTKREQKLMQRRQHAEELLEWKRRLDAEE-A 1887
SSS+T K S K + RE++ + +++ +E+ DAEE +
Sbjct: 1103 KRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESS 1162
Query: 1888 EIRQMEKQALAAWDKELIKPKTPKKELE-DQRTEQKEIASEEESPVPLYSHLN-SESSIP 1945
E + +KQ ++ K +I + + L + +Q +I S S + + E S
Sbjct: 1163 EDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSD 1222
Query: 1946 EELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPS------------KH 1993
E+ P E + S S D ++ + + + P K
Sbjct: 1223 EQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKA 1282
Query: 1994 SLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEG- 2052
+L S E +G RTG Q +E+ + SE+ SD + +
Sbjct: 1283 NLSSDEDGSSDDEPEEGKKRTGKQ--------NEENPGDEEAKNQVNSESDSDSEESKKP 1334
Query: 2053 --RIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQ 2110
R R L+ +L + KK + K KE +K + +K +E S+
Sbjct: 1335 RYRHRLLRHKLTVSDGESGEEKKTKPKEHKE-VKGRNR-------------RKVSSEDSE 1380
Query: 2111 DLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVD 2170
D + + + + S ++P+ + E +++K + R + +S +E
Sbjct: 1381 DSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSE--- 1437
Query: 2171 ASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALH 2230
+ S SE E+ + E + E+ + SP + +KIR+ D +
Sbjct: 1438 -NKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPG-KGRKKIRKILKDDKLRTETQN 1495
Query: 2231 LLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKK-SKIEDAFSKEGKSDVLLKLVL 2289
LKE E K+ +E E KL++ +IEDA K + KLVL
Sbjct: 1496 ALKEEE--------------ERRKRIAEREREREKLREVIEIEDA--SPTKCPITTKLVL 1539
Query: 2290 EQGDSSE 2296
++ + ++
Sbjct: 1540 DEDEETK 1546
Score = 68.9 bits (167), Expect = 7e-11
Identities = 258/1434 (17%), Positives = 536/1434 (37%), Gaps = 216/1434 (15%)
Query: 1411 ESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELTRTHISDAVVAS 1470
E+L+Q++Q ++ +V E + K+ T+R + C E + D+ S
Sbjct: 285 ENLEQLLQQNKKKIKVDSEKSNKV---YEHTSRFSPKKTSSNCNGEE---KKLDDSCSGS 338
Query: 1471 GAPLAILYDHQRQHLP-DFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSY 1529
+ Y + +P + +K+ + ET S + K+ T +S+ +S
Sbjct: 339 -----VTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSE----ISSATKL 389
Query: 1530 SESSGYKN--HDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRS 1587
+ +K+ D + + + ++ S + K K ID + +T A R
Sbjct: 390 RQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKA----RK 445
Query: 1588 DSVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDD 1647
P ++KD + K + ++ +++ + +P+E R + G H
Sbjct: 446 GEKPCALEKKDIS--------KSEAKLSRKQVDSEHMHQNVPTEEQR--TNKSTGGEHKK 495
Query: 1648 SDEEASPEKTTLSTAKELNM-----PFSGGQDSFSKFTMEMVRQYMKEE--------EMR 1694
SD + P+ +T+++L+M P S +D F M Q + E
Sbjct: 496 SDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQE 555
Query: 1695 AAHQSSLLRLREK----ALKEKTKAELAWLEHQK------KHLRDKGEDDKMPPLRK--- 1741
S L + K +K KT A++ + K + KG D + P K
Sbjct: 556 VESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGY 615
Query: 1742 KQRGLLLRLQ-----QEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLK 1796
K GL +L+ QE ++ + L E E L+L EE + R +K +
Sbjct: 616 KSCGLNPKLEKCGLGQENSDNEHLVE------NEVSLLL---EESDLRRSPRVKTTPLRR 666
Query: 1797 SAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEK 1856
+ + S+SD++ + ++ + S+ + K R+ D
Sbjct: 667 PTETNPVTSNSDEECNE-------------------TVKEKQKLSVPVRKKDKRNSSDSA 707
Query: 1857 FLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQA-LAAWDKELIKPKTPKKELE 1915
+ KL + +Q E ++ D A ++++ + + ++ D ++ + T K L
Sbjct: 708 IDNPKPNKLPKSKQ--SETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLY 765
Query: 1916 DQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILT 1975
D +T+ A +++ S S + G A + S+ Q Q S ++
Sbjct: 766 DLKTQ----AGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSEL 821
Query: 1976 EEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDES 2035
E+ I S + +K +P + S ++ Q H +K+ Q SD++
Sbjct: 822 EKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQE--GSSDDA 879
Query: 2036 LSMTQSETTSDQS---DIEGRIRALKDELRKRKSVVNQLKKEQKKRQKER-LKAQEASLI 2091
+ ET S D + I L+D L K++ K KE+ + E +
Sbjct: 880 ERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKV 939
Query: 2092 KQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKS 2151
+ + + +K + QD LS +EK K + + K K
Sbjct: 940 AETKEKSKHLKTKTCKKVQD------------GLSDIAEKFLKKDQSDETSEDDKKQSKK 987
Query: 2152 LTESERSRGSLES----IAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSP 2207
TE ++ + + + ++S G+E+ + + K + + + T D +
Sbjct: 988 GTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGE---- 1043
Query: 2208 VLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLK 2267
+ S+KIR+++ K+ + S + S GK G+S SE K
Sbjct: 1044 --KKSKKIRDKTS------------KKKDELSDYAEKSTGK-GDSCDSSEDK-------- 1080
Query: 2268 KSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGLAIENLHKSEE 2327
KSK A+ +E K KL+ + + S D + ++++D + + L + E
Sbjct: 1081 KSK-NGAYGREKKR---CKLLGKSSRKRQDCSSSDT--EKYSMKEDGCNSSDKRLKRIE- 1133
Query: 2328 MLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSEDFEVSSFKKE 2387
L+ER++ ++ IQSG + + + E + + + K+ ++ + +S +
Sbjct: 1134 -LRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRT- 1191
Query: 2388 ISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEISECLSEKSLSIH 2447
S + + D SS + D Q+ S G++ + ++E L S +
Sbjct: 1192 -STKRKQADITSSSSSDIEDDDQN---------SIGEGSSDEQKIKPVTENLVLSSHTGF 1241
Query: 2448 SNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESPSLASVP---TADELFDFHIGDRVL 2504
D L P + + D + E ++ + L + ++DE D D
Sbjct: 1242 CQSSGDEALSKSVPVTV--DDDDDDNDPENRIAKKMLLEEIKANLSSDE--DGSSDDEPE 1297
Query: 2505 IGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKIS 2564
G + G + G E K + N+ D + + +H + +S
Sbjct: 1298 EGKKRTGKQNEENP---------GDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVS 1348
Query: 2565 HIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYEKSLPSVNDIE 2624
+ E ++ R + +++ D++ +E VSE E +
Sbjct: 1349 DGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDF---QESGVSEEVSESE-------D 1398
Query: 2625 ASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKENKDLISDATEKVSIAAEDD 2684
R+RS K +A + + Q + + D++ + +E++
Sbjct: 1399 EQRPRTRSAK-------------KAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEE 1445
Query: 2685 TLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKS 2744
+ EE E++++ EE++N +++ K + +L +K + E Q ++L EE++
Sbjct: 1446 EEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQ--NALKEEEER 1503
Query: 2745 KQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKVTP 2798
++++ + + L +V +I+ K ++ + +L +D++ P
Sbjct: 1504 RKRIAEREREREKLREVI---------EIEDASPTKCPITTKLVLDEDEETKEP 1548
Score = 59.3 bits (142), Expect = 6e-08
Identities = 147/738 (19%), Positives = 287/738 (38%), Gaps = 122/738 (16%)
Query: 49 EVAPTSTAVCDSVMDTKKSSTSATRKISRKDGRYLDDSWVNAPISKSTKSRKEKSRSPLR 108
E P ++ + +T K + + +KD R DS ++ P K K K K +
Sbjct: 669 ETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNP--KPNKLPKSK-----Q 721
Query: 109 ATTLESNVKKNNRVEFREPLVSYREIHGAPSNFSSSHLESKHVYCVDVNEEKTESGNWMI 168
+ T++ N + + + + R H + S+ + + + H D+ KT++G
Sbjct: 722 SETVDQNSDSDEMLAILKEVS--RMSHSSSSDTDINEIHTNHKTLYDL---KTQAGKDDK 776
Query: 169 GSREERNIRS-CDFE-----SSQSSVINDTVVRFLNDRPAIDALQNSEC--LIRMGASMR 220
G R+ ++ S DF+ S++SS+I+ + ++ D+ E + ++GA+
Sbjct: 777 GKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAART 836
Query: 221 TEEEMPNRT------------KGSEN----NLKLSVNNMAHDTDPKALRLTDSSPSSTST 264
T++ +PN KG +N NLK S + D + K R T SS T
Sbjct: 837 TKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVD 896
Query: 265 SNSQRLDILKRRQHDVKLEKLKERIRKQWEHSEETNGRGQKLGHIDHPVMVVNVDNSVTA 324
D + +L++R+ K+ + S T+G + G + S T+
Sbjct: 897 K-------------DTTIMELRDRLPKKQQASASTDGVDKLSGK----------EQSFTS 933
Query: 325 -KVRKVATAPPAPAYKGFNPSETKIRTPDGKVWQEAEFQNMSRELYRDLALHFADDISIK 383
+VRKVA + ++T K Q+ + L +D + ++D +
Sbjct: 934 LEVRKVAETKEKSKH---------LKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQ 984
Query: 384 EKPA--EKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHLISTSSWRDGQKLVKKILGPAP 441
K EK K K V K+++ + SS G+ L K +K+I
Sbjct: 985 SKKGTEEKKKPSDFKKKVIKMEQQYESSSD----GTEKLPEREEICHFPKGIKQIKNGTT 1040
Query: 442 RMEPKEQRTASSDRGGRERTAKSGGHI--------GRAES-DPRLDVLHRHLQRNSERSR 492
E K ++ R++T+K + G+ +S D D ++ E+ R
Sbjct: 1041 DGEKKSKKI-------RDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKR 1093
Query: 493 SKSRSENNIKKLASSLPDN-----KQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQD 547
K +++ K+ S D K++ + +K IE+R + ++K++
Sbjct: 1094 CKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELR--------ERRNLSSKRN 1145
Query: 548 TVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYD----TDEVRQYIVRQ 603
T E+Q+ SS+ A S K+K + ++ + ++ +++ T + I
Sbjct: 1146 TKEIQSGSSSSD--AEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSS 1203
Query: 604 QEERKRKQNEEKKAQKEATEQKNKRLQE----------LYRKQKEAFTKVKNVPPSEPSA 653
++ + + EQK K + E EA +K V +
Sbjct: 1204 SSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDD 1263
Query: 654 TRRLQETYSK-LLLEKTLLEEPSHQHVTQETQAKPGYQPSGESDKENKVQERPPS-ASSS 711
+ +K +LLE+ S + + + + + G + +G+ ++EN E + +S
Sbjct: 1264 DNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSE 1323
Query: 712 SDMSLSEPPQPLARKDLM 729
SD E +P R L+
Sbjct: 1324 SDSDSEESKKPRYRHRLL 1341
Score = 43.5 bits (101), Expect = 0.003
Identities = 200/1087 (18%), Positives = 394/1087 (36%), Gaps = 125/1087 (11%)
Query: 1134 PQEDHSNRKSAYD-PSSVDVTSQHSSGAQSAASSRS---STSSKGKKG--------KKEK 1181
P++ N ++A + SSVD SSG + S S + SSK +G K K
Sbjct: 525 PEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTK 584
Query: 1182 TEWLDSFTGNVQNSLL---DEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTDSTLEDLSG 1238
++ ++ NS + D ++ + K G + KL Q + L +
Sbjct: 585 ELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEV 644
Query: 1239 HSVSVSSDKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTD 1298
+ SD RS + T+PL ++ + V S E +V K + P+
Sbjct: 645 SLLLEESDLRRSPRVKTTPLRRPTETN---PVTSNSDEECNETVKEKQ----KLSVPVRK 697
Query: 1299 LNPA-ASRTTTENMAP--IPGSKRFSPAGLHHRMAAELSYLNAIEESVRQLSDVERVRGI 1355
+ +S + +N P +P SK+ + L+ L + S + I
Sbjct: 698 KDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEI 757
Query: 1356 SLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQ 1415
+ L K Q + ++ K ++++ S + + K+A+
Sbjct: 758 HTNHKTLYDL----KTQAGKDDKG------KRKRKSSTSGSDFDTKKGKSAK------SS 801
Query: 1416 VVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAELTRTHISDAVVASGAPLA 1475
++ ++ T QSE++ ++ ++I M+++ + + +
Sbjct: 802 IISKKKRQT-------------QSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFD 848
Query: 1476 ILYD--HQRQHLPDFV-KQLRTRTE-----TDRKSPSVSLSQSKEGTLDS---------- 1517
D H ++ + + K L+T E +RK + S S EGT+D
Sbjct: 849 SSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFS-SAEGTVDKDTTIMELRDR 907
Query: 1518 --KHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDE 1575
K Q+ SAS D + SG + E V KE K L K + +
Sbjct: 908 LPKKQQASASTDGVDKLSG-------KEQSFTSLEVRKVAETKEKSKHLK-TKTCKKVQD 959
Query: 1576 QVQTAADDSLRSD-SVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRS-------L 1627
+ A+ L+ D S + D+K + TE K + + EQ + S L
Sbjct: 960 GLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKL 1019
Query: 1628 LPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMVRQY 1687
E F ++ + +D E +K T+K+ + + S K +
Sbjct: 1020 PEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED 1079
Query: 1688 MKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKG---EDDKMPPLRKKQR 1744
K + + +L K+ +++ + + +K +++ G D ++ + ++R
Sbjct: 1080 KKSKNGAYGREKKRCKLLGKSSRKRQDCSSS--DTEKYSMKEDGCNSSDKRLKRIELRER 1137
Query: 1745 GLLLRLQQEK--------AEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLK 1796
L + K ++ + E NK +K+R K+ +++ ++ +++ K K
Sbjct: 1138 RNLSSKRNTKEIQSGSSSSDAEESSEDNKK-KKQRTSSKKKAVIVKEKKRNSLRTSTKRK 1196
Query: 1797 SAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPIS---ISSSETSSIMQKLKKMRSRM 1853
A + S S D +D+ S G + + P++ + SS T + S+
Sbjct: 1197 QAD---ITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKS 1253
Query: 1854 DEKFLTKREQKLMQRRQHAEELL--EWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPK 1911
+ + + A+++L E K L ++E E + + +
Sbjct: 1254 VPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGD 1313
Query: 1912 KELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDH 1971
+E ++Q + + + EES P Y H + G E +E G
Sbjct: 1314 EEAKNQVNSESD-SDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRR 1372
Query: 1972 SILTEEMICSQELESSTSPS---KHSLPKSCTSVSKQESSKGSHRTGGQC--HLPIKSHQ 2026
+ +E+ S ES S + T +K+ + + R+ Q IK +
Sbjct: 1373 KVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQE 1432
Query: 2027 HCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQ 2086
S + + + E ++ + E +DE KS KK +K + ++L+ +
Sbjct: 1433 DSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTE 1492
Query: 2087 EASLIKQLESYDEFIKKTEAELSQDLET------SPTAKPQIKTLSSASEKPKIKPLTPL 2140
+ +K+ E + I + E E + E SPT P L ++ +PL +
Sbjct: 1493 TQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQV 1552
Query: 2141 HRSETAK 2147
HR+ K
Sbjct: 1553 HRNMVIK 1559
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 79.0 bits (193), Expect = 7e-14
Identities = 258/1334 (19%), Positives = 517/1334 (38%), Gaps = 169/1334 (12%)
Query: 1210 KKSGTSSKL-SVKDFEQTLDTDSTLEDLSGHSVSVSSDKGRSQKTPTSPLSPSSQKSLQF 1268
KK+ SSK+ S+ D+ DS + G+ + S KG ++ +S S S+ SL
Sbjct: 235 KKTSKSSKIRSLADYRTE---DSNAGNSGGNVPAPDSTKGSLKQNRSSAASVVSEISLSP 291
Query: 1269 DVAGTSSERSKSSVMPPTITGFKPN-APLTDLNPAASRTTTENMAPIPGSKRFSPAGLHH 1327
D T +S+ +++ N + + + A++R T ++ G++
Sbjct: 292 D---TDDRLENTSLAGDSVSEVDGNDSDSSSYSSASTRGTYGILSKTVGTQDTPYMVNGQ 348
Query: 1328 RMAAEL-----SYLNAIEESVRQLSDV-ERVRGISLAQQESVSLAQIIKAQQQRHERDLA 1381
+ A+ S + ++ + + D + V G ++++S+ + +++ + ++
Sbjct: 349 EIPADTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEM- 407
Query: 1382 LLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQ-SE 1440
L+ +E + + QLE +A+Q E + Q T++ + C ++QQ +
Sbjct: 408 ---LQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQD 464
Query: 1441 TARLTTDAARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDR 1500
+ D +Q C E T + + + A A LA ++ Q + ++L + E +
Sbjct: 465 SLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLA-SSNNDLQVAEEQYQRLMAKVEDMQ 523
Query: 1501 KSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPS---- 1556
+S SK+ T+ Q+ +A S + + S +S+ E S+ S
Sbjct: 524 RS-----MLSKDNTVHDLRQQMTA-LQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQW 577
Query: 1557 -------CKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDE---------KDST 1600
+E +L GE + + Q + L+ ++V SL + K+
Sbjct: 578 YQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENV-SLSQQLTETQHRSMKEKG 636
Query: 1601 SIATEYSLKFDESMTEDE---IEEQSFRSLLPSESHRRF-NMEKRRGHHDDSDEEASPEK 1656
IA + + M + E ++ Q ++++ + RR E R + A+ +
Sbjct: 637 RIAAQLQ-GIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLE 695
Query: 1657 TTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAE 1716
L K + ++ + +++++Q +E + + SL L+ ++ +A
Sbjct: 696 QQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTH--YDELQAR 753
Query: 1717 LAWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILK 1776
L L+ + D + LQ EK ++ +A K+ ++E +
Sbjct: 754 LGELQGEAASRED----------------TICLLQNEKIILEAALQAAKSGKEELDRGAR 797
Query: 1777 QQEE-IEKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISIS 1835
+ EE E+ +T KL+E+L A +S H +T K + + +
Sbjct: 798 RLEEGTEETSETLEKLREEL--AIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAY 855
Query: 1836 SSETSS---IMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQM 1892
+ +S ++ +LK R R+D + L + Q+LMQ RL E A++R
Sbjct: 856 RRDATSKDQLISELKATRKRLDSE-LKELRQELMQVHGEKRTAEAELSRLHREVAQVR-- 912
Query: 1893 EKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPA 1952
Q +A + L ++ +KE ++ T + + ++E V + + EEL A
Sbjct: 913 --QHMADLEGHL---QSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEA 967
Query: 1953 VEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSH 2012
+ + + + GS S E + E++ L ++ + ++ G
Sbjct: 968 RKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQL 1027
Query: 2013 RT-GGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQL 2071
R GG + H+ + E +++ S+T ++ +++ I EL + + V +L
Sbjct: 1028 RAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEK-ELQEVIALTSQELEESREKVLEL 1086
Query: 2072 KKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQD------LETSPTAKPQIKTL 2125
+ E ++ + R K IK+LE E KK EL + L S A + ++
Sbjct: 1087 EDELQESRGFRKK------IKRLE---ESNKKLALELEHEKGKLTGLGQSNAALREHNSI 1137
Query: 2126 SSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSL 2185
+ + L L+ A L E ++ + + + ASL + V+
Sbjct: 1138 LETALAKREADLVQLNLQVQA----VLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKE 1193
Query: 2186 SAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMS 2245
A +V +R F+ S L +K E HL+++L A + L +
Sbjct: 1194 QVAAAKVEAGHNR-RHFKAASLELSEVKK---------ELQAKEHLVQKLQAEADDLQIR 1243
Query: 2246 DGKVGESSKKSEIKEIE---YTKLKKSKIEDAFSKE--GKSDV-LLKLVLEQGDSSEILS 2299
+GK + + + + E +L + ++++ SK+ G ++ LK ++Q +
Sbjct: 1244 EGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSL 1303
Query: 2300 KKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEK 2359
K+ L L + +K+L GL + L + L+ Q D M + E KN +
Sbjct: 1304 KQQLDLTEQQGRKELEGLQ-QLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKT 1362
Query: 2360 DLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPM 2419
L ++ L L LR+ + R +P+
Sbjct: 1363 LLQQNQQL----------------------------------KLDLRRGAAKTRKEPKGE 1388
Query: 2420 RSSTSGATSFGSNEEISEC-----LSEKSLSIHSNVHSDRLLELKSPTELMK----SKER 2470
SS++ AT +I +C L E+ L V + L L S + +K S +R
Sbjct: 1389 ASSSNPATPI----KIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQR 1444
Query: 2471 SDVEHEQQVTESPS 2484
EH V ES S
Sbjct: 1445 QMEEHALTVHESLS 1458
Score = 52.0 bits (123), Expect = 9e-06
Identities = 141/716 (19%), Positives = 280/716 (39%), Gaps = 76/716 (10%)
Query: 1192 VQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTDSTLEDLSGHSVSVSSDKGRSQ 1251
+QN + E A + + GK+ ++ E T +T TLE L +++ S +
Sbjct: 771 LQNEKIILEAALQAAKSGKEELDRGARRLE--EGTEETSETLEKLR-EELAIKSGQVEHL 827
Query: 1252 KTPTSPLSPSSQKS----LQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASRTT 1307
+ T+ L QK LQ V + R +S I+ K D + +
Sbjct: 828 QQETAALKKQMQKIKEQFLQQKVMVEAYRRDATS-KDQLISELKATRKRLD---SELKEL 883
Query: 1308 TENMAPIPGSKRFSPAGLHHRMAAELSYLNAIEESVRQ-LSDVERVRGISLAQQESVSLA 1366
+ + + G KR + A ELS L+ VRQ ++D+E + AQ+E +
Sbjct: 884 RQELMQVHGEKRTAEA--------ELSRLHREVAQVRQHMADLEG--HLQSAQKERDEME 933
Query: 1367 QIIKAQQQRHERDLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEV 1426
+++ Q E+ +A+ + EAL+ +Q+EE + +A + E Q++ + ++T
Sbjct: 934 THLQSLQFDKEQMVAVTEAN---EALK--KQIEELQQEARKAITEQKQKMRRLGSDLTSA 988
Query: 1427 LQEATCKIAAQQSETARLTTDAARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLP 1486
+E K A ++ L+ ++ E + G+ + L H+R
Sbjct: 989 QKEMKTKHKAYENAVGILSR-RLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQAL 1047
Query: 1487 DFVKQLRTRTET--DRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSS 1544
+ Q + ++T +++ V S+E L+ +K D ES G++ +R
Sbjct: 1048 EAELQAVSHSKTLLEKELQEVIALTSQE--LEESREKVLELEDELQESRGFRKKIKRLEE 1105
Query: 1545 GSSR------QESPSVPSCKENEKKLNGEK--IESSIDEQVQTAADDSLRSDSVPSLPDE 1596
+ + E + ++ L +E+++ ++ +L+ +V +E
Sbjct: 1106 SNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEE 1165
Query: 1597 KDSTSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEK 1656
+D +L+ E E++ SL + + R H + E S K
Sbjct: 1166 EDRQMKHLVQALQ-----ASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVK 1220
Query: 1657 TTLSTAKELNMPFSGGQDSFS----KFTMEMVRQYMKEEEMRAAHQSSLLRLREKALK-- 1710
L + L D K + E+ + + E RA Q +L E+ K
Sbjct: 1221 KELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQP 1280
Query: 1711 ------EKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLRLQQEKAEIKRLQEAN 1764
E K E+ E + + L+ + + + RK+ GL LQ K+E++ QE
Sbjct: 1281 VGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQG-RKELEGLQQLLQNVKSELEMAQEDL 1339
Query: 1765 KAARKERQLILKQQEEIEKIRQTTIKLQEKLK-----SAGESKLD-----SHSDDDTKDN 1814
+K++ ++ + E++ +T ++ ++LK A +++ + S S+ T
Sbjct: 1340 SMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIK 1399
Query: 1815 KATSPGPTDL--------ETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKRE 1862
P P L S P+ +S + Q++ ++ +M+E LT E
Sbjct: 1400 IPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALTVHE 1455
Score = 45.8 bits (107), Expect = 7e-04
Identities = 193/982 (19%), Positives = 363/982 (36%), Gaps = 116/982 (11%)
Query: 2035 SLSMTQSETTSDQSDI----EGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASL 2090
SL M +++ S S + E ++R L+ RK + QLK+ + KRQ+ER +Q A+
Sbjct: 127 SLPMQETQLCSTDSPLPLEKEEQVR-----LQARKWLEEQLKQYRVKRQQER-SSQPATK 180
Query: 2091 IKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPL-TPLHRSETAKNW 2149
+ + D + L + T K +S PK+ L P H E
Sbjct: 181 TRLFSTLDPELMLNPENLPR-ASTLAMTKEYSFLRTSVPRGPKVGSLGLPAHPRE----- 234
Query: 2150 KSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVL 2209
K ++S + R + E +A SG + + + + + S + SP
Sbjct: 235 KKTSKSSKIRSLADYRTEDSNAGNSGGNVPAPDSTKGSLKQNRSSAASVVSEISL-SPDT 293
Query: 2210 RSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKKS 2269
+ +GDS+ V + +++S + G G SK ++ Y +
Sbjct: 294 DDRLENTSLAGDSVSEVDG----NDSDSSSYSSASTRGTYGILSKTVGTQDTPYMVNGQE 349
Query: 2270 KIEDAFSK-EGKSDVLLKLVLEQGD-----SSEILSKKDLPLDSENVQKDLVGLAIENLH 2323
D + DVL E D + E+ S++D S +++ A E
Sbjct: 350 IPADTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESS----AAETQE 405
Query: 2324 KSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSEDFEVSS 2383
+ ++LKE+ + + ++++ + + E+ + + + S L A E +S S
Sbjct: 406 EMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDS 465
Query: 2384 FKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEISECLSEKS 2443
E+ QSC D + M + + + S S
Sbjct: 466 LSSEVDTL-----------------KQSCWDLERAM----TDLQNMLEAKNASLASSNND 504
Query: 2444 LSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESPSLASVPTADELFDFHIGDRV 2503
L + + + +++ M SK+ + + QQ+T S +L +
Sbjct: 505 LQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQS--------QLQQVQLERTT 556
Query: 2504 LIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKI 2563
L ++ S + W +L + +A+ + G +
Sbjct: 557 LTSKLKASQAEISSLQSVRQ--WYQQQLALAQEARVRLQGEMAHIQV----GQMTQAGLL 610
Query: 2564 SHIP-ENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYEKSLPSVND 2622
H+ EN + E + E+ + Q Q D+E + K++ D
Sbjct: 611 EHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVE-ED 669
Query: 2623 IEASVNRSRSLKIETDNVQDISGVLEAHVHQ------QSSVDSQISSKENKDLISDAT-E 2675
++ + + + D + LE + Q Q + +E+ DL+ T
Sbjct: 670 LQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLT 729
Query: 2676 KVSIAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQLEAQL- 2734
+ ++ + + +LD + E Q + E L EA+ + T + LL EK LEA L
Sbjct: 730 QEALQSREQSLDALQTHYDELQARLGE----LQGEAASREDT--ICLLQNEKIILEAALQ 783
Query: 2735 --KSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLGDD 2792
KS E + ++LE+ + T L+ ++ + Q++ + E L Q
Sbjct: 784 AAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQ------ 837
Query: 2793 QKKVTPQDLSQNVEEQS---PSISGCFLSSELEDEKEEISSPDMCPRPESPVFGASGQEE 2849
+K+ Q L Q V ++ + S L SEL+ ++ + S R E + G+
Sbjct: 838 MQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQE--LMQVHGE-- 893
Query: 2850 LAKRLAELELSREFLSALGDDQDWFDEDFGLSSSHKIQKNKAEETIVPLMAEPKRVTQQP 2909
KR AE ELSR Q D + L S+ K ++++ E + L + +++
Sbjct: 894 --KRTAEAELSRLHREVAQVRQHMADLEGHLQSAQK-ERDEMETHLQSLQFDKEQMV-AV 949
Query: 2910 CETLLAVPHTAEEVEILVHNA-AEELWKWKELGHDLHSISIPTKLLGCASKGLDIESTSK 2968
E A+ EE++ A E+ K + LG DL S K T
Sbjct: 950 TEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMK-------------TKH 996
Query: 2969 RVYKQAVFDLTKEIFEEIFAED 2990
+ Y+ AV L++ + E + A++
Sbjct: 997 KAYENAVGILSRRLQEALAAKE 1018
Score = 40.0 bits (92), Expect = 0.036
Identities = 53/230 (23%), Positives = 95/230 (41%), Gaps = 28/230 (12%)
Query: 455 RGGRERTAKSGGHI--GRAESDPRLDVLHRHLQRNSERSRSKSRSENNIKKLASSLPDNK 512
+ G+E + + G E+ L+ L L S + + +KK + +
Sbjct: 786 KSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQF 845
Query: 513 QEENT--------ALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVELQNQKSSAPVHAPR 564
++ A +KD L E++ +LDS +Q+ +++ +K +A R
Sbjct: 846 LQQKVMVEAYRRDATSKDQLISELKATRK--RLDSELKELRQELMQVHGEKRTAEAELSR 903
Query: 565 SHSPVKRKPDKITANEDPPVISKRRHYDT----------DEVRQYIVRQQEERKRKQNEE 614
H V + + A+ + + S ++ D D+ + V + E +KQ EE
Sbjct: 904 LHREVAQVRQHM-ADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEE 962
Query: 615 --KKAQKEATEQKNKRLQ---ELYRKQKEAFTKVKNVPPSEPSATRRLQE 659
++A+K TEQK K + +L QKE TK K + +RRLQE
Sbjct: 963 LQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQE 1012
Score = 38.1 bits (87), Expect = 0.14
Identities = 208/1098 (18%), Positives = 422/1098 (38%), Gaps = 169/1098 (15%)
Query: 1830 SPISISSS--ETSSIMQKLKKMRSRMD---EKFLTKREQKLMQRRQHAEELLEWKRRLDA 1884
S +S+ SS ET M ++ K + R++ E + Q L ++ + +L +L A
Sbjct: 392 SSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQA 451
Query: 1885 EEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSI 1944
+ E +Q + E+ K +LE T+ + + + + + + N++ +
Sbjct: 452 Q-VECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASL---ASSNNDLQV 507
Query: 1945 PEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSK 2004
EE + V + H + Q++ + S + + T SK
Sbjct: 508 AEEQYQRLMAKVEDMQRSMLSKDNTVHDL-------RQQMTALQSQLQQVQLERTTLTSK 560
Query: 2005 QESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIE----------GRI 2054
++S+ I S Q W + L++ Q Q ++ G +
Sbjct: 561 LKASQAE----------ISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLL 610
Query: 2055 RALKDELRKRKSVVNQLKKEQKKRQKER------LKAQEASLIKQLESY---DEFIKKTE 2105
LK E S+ QL + Q + KE+ L+ EA ++ Q ++ E E
Sbjct: 611 EHLKLE---NVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVE 667
Query: 2106 AELSQDLETSPTAKPQIKTL--SSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLE 2163
+L + LE + +++ + S+AS + +++ + LT +R + LE
Sbjct: 668 EDLQRRLEEFEGERERLQRMADSAASLEQQLEQV-------------KLTLLQRDQ-QLE 713
Query: 2164 SIA-EHVDA----SLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSP-------VLRS 2211
++ EH+D +L+ E+SL A +E +R + Q + +L++
Sbjct: 714 ALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQN 773
Query: 2212 SRKIRE------ESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTK 2265
+ I E +SG + A L + TS L+ ++ S + E + E
Sbjct: 774 EKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAA 833
Query: 2266 LKKS--KIEDAFSKEGKSDVLLKLVLEQGDSSEIL------SKKDLPLDSENVQKDLVGL 2317
LKK KI++ F ++ V+++ S + L ++K L + + ++++L+ +
Sbjct: 834 LKKQMQKIKEQFLQQ---KVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQV 890
Query: 2318 ---------AIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWS-EHL 2367
+ LH+ +++ +D + ++QS + ++ T + L + E +
Sbjct: 891 HGEKRTAEAELSRLHREVAQVRQHMADLE----GHLQSAQKERDEMETHLQSLQFDKEQM 946
Query: 2368 FAPKEIPYSEDFEVSSFKKEISAELYKDDFEV----SSLLSLRKDSQSCRDKPQ------ 2417
A E + ++ ++E + + ++ S L S +K+ ++ +
Sbjct: 947 VAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGIL 1006
Query: 2418 PMRSSTSGATSFGSNEEISECL-----SEKSLSIHSNVHS-DRLLELKSPTELMKSKERS 2471
R + A ++ E+ + S+ SL++H + + + L+ S ++ + KE
Sbjct: 1007 SRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQ 1066
Query: 2472 DVEH--EQQVTESPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGV 2529
+V Q++ ES + DEL + G R I ++ + E KG G+
Sbjct: 1067 EVIALTSQELEESREKV-LELEDELQESR-GFRKKIKRLEESNKKLALELEHEKGKLTGL 1124
Query: 2530 ELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQ 2589
G +N +E + I + + + D V +N + +
Sbjct: 1125 ------GQSNAAL--------REHNSILE-----TALAKREADLVQLNLQVQAVLQRKEE 1165
Query: 2590 CYNQEQNDTEGPK-DREKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNVQDISGVLE 2648
Q ++ + + EK+ + K + +EA NR R K + + ++ L+
Sbjct: 1166 EDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNR-RHFKAASLELSEVKKELQ 1224
Query: 2649 AHVH-----QQSSVDSQI-SSKENKDLISDATEKVSIAAEDDTLDNTFSEELEKQQQFTE 2702
A H Q + D QI K ++++ E A+ L E+L KQ +
Sbjct: 1225 AKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQ 1284
Query: 2703 EEDNLYAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVF 2762
E +NL E +K RE L+ QL + + +K + L+++ S L++
Sbjct: 1285 EMENLKWEVDQK---------EREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMA 1335
Query: 2763 VKDTVNQLQQIKKTRDEKI-QLSNQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSEL 2821
+D ++ Q+ K K+ +L N Q + DL + + G SS
Sbjct: 1336 QED-LSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSS-- 1392
Query: 2822 EDEKEEISSPDMCPRPES 2839
+ I PD CP P S
Sbjct: 1393 -NPATPIKIPD-CPVPAS 1408
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 77.8 bits (190), Expect = 2e-13
Identities = 201/1012 (19%), Positives = 403/1012 (39%), Gaps = 121/1012 (11%)
Query: 1477 LYDHQRQHLP-DFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGY 1535
L++ + +P DF E D+ +P V L+ + + + +K E
Sbjct: 72 LHESDSESVPRDFKLSDALAVEDDQVAP-VPLNVVETSSSVRERKKKEKKQKPVLEEQVI 130
Query: 1536 KNHDRRSSSGSSRQ-----ESPSVPSCKENEKKLNGEKIESS----IDEQVQTAADDSLR 1586
K D G + + P+ PS KK G+K + D++V+T S R
Sbjct: 131 KESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKR 190
Query: 1587 SDSVPSLPDEK-DSTSIATEYSLKFDES----MTEDEIEEQSFRSLLPSESH-----RRF 1636
+++P + K +S S + S K ++ + E I ++ L+ + +R
Sbjct: 191 QEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKRE 250
Query: 1637 NMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAA 1696
++ + + +++ +K T KE + F F + + E+E A
Sbjct: 251 VIDLLKPDQVEGIQKSGTKKLKTETDKE------NAEVKFKDFLLSLKTMMFSEDE--AL 302
Query: 1697 HQSSLLRLR----EKALKEKTKAELAWLEHQ----KKHLRDKGEDDKMPPLRKKQRGLLL 1748
LL+ + + ALK+ +K EL L HQ K L ED R KQ +
Sbjct: 303 CVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM 362
Query: 1749 RLQQEKAE--IKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLDSH 1806
++E++ I R+++ KE + Q +I Q T ++Q K + E ++++
Sbjct: 363 MTEKERSNVVITRMKDRIGTLEKEHNVF---QNKIHVSYQETQQMQMKFQQVRE-QMEAE 418
Query: 1807 SDDDTKDN----KATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKRE 1862
++N A S LE++ S+E + + Q ++ + + EK K +
Sbjct: 419 IAHLKQENGILRDAVSNTTNQLESKQ-------SAELNKLRQDYARLVNELTEK-TGKLQ 470
Query: 1863 QKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTEQK 1922
Q+ +Q++ + + K +L +EAE R E Q+ I+ +T + E Q + K
Sbjct: 471 QEEVQKKNAEQAATQLKVQL--QEAERRWEEVQSY-------IRKRTAEHEAAQQDLQSK 521
Query: 1923 EIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQ 1982
+A E E L+S L ++L ++ + SE + S + Q
Sbjct: 522 FVAKENEVQ-SLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQV--------Q 572
Query: 1983 ELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSE 2042
++ K + + + ++ Q S+ + H I +++SL+ +
Sbjct: 573 DILEQNEALKAQIQQFHSQIAAQTSASV---LAEELHKVIAEKDKQIKQTEDSLASERDR 629
Query: 2043 TTSDQS---DIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDE 2099
TS + DI+ LK E++K +++ N EQ E K Q++ +K +
Sbjct: 630 LTSKEEELKDIQNMNFLLKAEVQKLQALAN----EQAAAAHELEKMQQSVYVKD-DKIRL 684
Query: 2100 FIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSR 2159
++ + E+S +E Q K L S +K + ++ + K + E +
Sbjct: 685 LEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKL 744
Query: 2160 GSLESIAEH--VDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIRE 2217
++E + E + + E + S+ K V + ++ D + + ++ +K+
Sbjct: 745 KTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIH 804
Query: 2218 ESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSK 2277
E +++V L + L ++ + D K + K EI ++ K ++ I +
Sbjct: 805 EKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQE 864
Query: 2278 -----EGKSDVL--LKLVLEQGDSSEILSKK---DLPLDSENVQKDLVGLAIENLHKS-- 2325
+GK + + +K VLE+ + + K DL ++E+++ + +A NL ++
Sbjct: 865 LQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASS 924
Query: 2326 ---------------------EEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWS 2364
E MLKER+SD + + +Q +D ++ ++ + L
Sbjct: 925 ASQFEELEIVLKEKENELKRLEAMLKERESDLS-SKTQLLQDVQDENKLFKSQIEQLKQQ 983
Query: 2365 EHLFAPKEIPYSEDFEV-SSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDK 2415
+ A P+ E +V S +KEIS + D ++ RK + R+K
Sbjct: 984 NYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREK 1035
Score = 57.4 bits (137), Expect = 2e-07
Identities = 254/1334 (19%), Positives = 518/1334 (38%), Gaps = 239/1334 (17%)
Query: 1309 ENMAPIPGSKRFSPAGLHHRMAAELSYLNAIEESVRQLSDVERVRG-----ISLAQQ--- 1360
+ +AP+P + + + + R E +EE V + SD ++ G + + +Q
Sbjct: 95 DQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTP 154
Query: 1361 ESVSLAQIIKAQQQRHERDL--------ALLKLKAEQEAL----ESQRQLEETRNKAAQ- 1407
S + A K Q++ + L+ QEAL E++++ + KA+
Sbjct: 155 PSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSK 214
Query: 1408 -------------VHAESL--------QQVVQSQREVTEVLQEATCKIAAQQSETARLTT 1446
+HA + V +REV ++L+ + Q+S T +L T
Sbjct: 215 KQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVE-GIQKSGTKKLKT 273
Query: 1447 DAARQICE----------------------MAELTRTH---ISDAVVASGAPLAILYDHQ 1481
+ ++ E + +L + I DA+ S HQ
Sbjct: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQ 333
Query: 1482 RQH--------------LPDFVKQLRTRTETDRKSPSVSLSQSKE--GTLDSKHQKY-SA 1524
Q D KQL T+++ +V +++ K+ GTL+ +H + +
Sbjct: 334 LQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK 393
Query: 1525 SYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDS 1584
+ SY E+ + + + E+ +EN + ++ E Q+A +
Sbjct: 394 IHVSYQET---QQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK 450
Query: 1585 LRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRSLLP--SESHRRFN----- 1637
LR D + + TE + K + + + EQ+ L E+ RR+
Sbjct: 451 LRQDYARLVNE-------LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSY 503
Query: 1638 MEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSF-SKFTMEMVRQYMKEEEMRAA 1696
+ KR H+ + ++ + ++ E+ S D+ SK +E + E E +
Sbjct: 504 IRKRTAEHEAAQQDL--QSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRV 561
Query: 1697 HQSSLLRLREKALKEKTKAELAWLEH---------------QKKHLRDKGEDDKMPPLRK 1741
++ L+++ + + E+ +A A ++ ++ H +D ++
Sbjct: 562 NKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTED 621
Query: 1742 KQRGLLLRLQQEKAEIKRLQEAN---KAARKERQLILKQQ----EEIEKIRQTTIKLQEK 1794
RL ++ E+K +Q N KA ++ Q + +Q E+EK++Q+ +K
Sbjct: 622 SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 681
Query: 1795 LKSAGESKLDSHSDDDTK------DNKATSPGPTDLETRSPSPISISSSETSSIMQKLKK 1848
++ E S+ + NKA L+T +S ++++++K
Sbjct: 682 IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQT------LVSEQPNKDVVEQMEK 735
Query: 1849 MRSRMDEKFLTKR---EQKLMQRRQHAEELLEWKRR-----LDAEEAEIRQMEKQALAAW 1900
DEK T E L+Q EEL + + ++ + +Q ++ + A+
Sbjct: 736 CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASL 795
Query: 1901 DKELIKPKTPK----KELED-QRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEY 1955
+EL K K K +E+ E ++A++E++ L + ++ EE+G+ +E
Sbjct: 796 VEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEI---KALKEEIGNVQLEK 852
Query: 1956 VPSESI------------GQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVS 2003
SI G+E+ + ++L E+ ++ ++T L +
Sbjct: 853 AQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEK----EKDLANTGKWLQDLQE------ 902
Query: 2004 KQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRK 2063
+ ES K + Q +L S + E L + E ++ +E ++ + +L
Sbjct: 903 ENESLKAHVQEVAQHNLKEASSASQF----EELEIVLKEKENELKRLEAMLKERESDLSS 958
Query: 2064 RKSVVNQLKKEQK--KRQKERLKAQEASLIKQLESYDEFIK---KTEAELS---QDLETS 2115
+ ++ ++ E K K Q E+LK Q ++E +K + E E+S +L++
Sbjct: 959 KTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSL 1018
Query: 2116 PTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSG 2175
A + ++ + + + L +E K S+ + +E++ L
Sbjct: 1019 KDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKK 1078
Query: 2176 SERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPAL-HLLKE 2234
VS S +Y + ++ ++ + ++ + SG E V L H LKE
Sbjct: 1079 LFPKVSVPSNLSYGEWLHGFEKKAKECMAGT------------SGS--EEVKVLEHKLKE 1124
Query: 2235 LNATSRILDMSDGKVGESSKKSEIKEIE--YTKLKKSKIEDAFSKEGKSDVLLKLVLEQG 2292
+ +L + K KS + E E KL++S ++ + K D K ++Q
Sbjct: 1125 ADEMHTLLQLECEKY-----KSVLAETEGILQKLQRSVEQEENKWKVKVDESHK-TIKQM 1178
Query: 2293 DSSEILSKKDLP-LDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIH 2351
SS S+++L L SEN KD IENL + E L+ +M S + +++
Sbjct: 1179 QSSFTSSEQELERLRSEN--KD-----IENLRREREHLEMELEKAEMERSTYVTEVRELK 1231
Query: 2352 EQKNTKEKDL--SWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDS 2409
+ +K L S+SE + ++ E++ K +++ L K E + + D
Sbjct: 1232 DLLTELQKKLDDSYSEAV--------RQNEELNLLKAQLNETLTKLRTEQNERQKVAGDL 1283
Query: 2410 QSCRDKPQPMRS---STSGATSFGSNEEIS---ECLSEKSLSIHSNVHSDRLLELKSPTE 2463
+ + ++S +G T+ N ++S E ++++S+ N +L +L
Sbjct: 1284 HKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVN 1343
Query: 2464 LMKSKERSDVEHEQ 2477
+KE+ EH Q
Sbjct: 1344 QQLTKEK---EHYQ 1354
Score = 49.7 bits (117), Expect = 5e-05
Identities = 128/694 (18%), Positives = 265/694 (38%), Gaps = 111/694 (15%)
Query: 1262 SQKSLQFDVAGTSSERSKSSVMP-PTITGFKPNAPLTDLNPAASRTTTENMAPIPGSKRF 1320
S K +F + ++ KS V T+ +PN + + + E + + +
Sbjct: 694 SNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTV---EEL 750
Query: 1321 SPAGLHHRMAAELSYLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQR-HERD 1379
GL ++A + LNAI L+ + V+ + Q + VS A +++ ++ HE+D
Sbjct: 751 LETGLI-QVATKEEELNAIRTENSSLT--KEVQDLKAKQNDQVSFASLVEELKKVIHEKD 807
Query: 1380 LALLKLKAEQEALESQ---------------RQLEETRNKAAQVHAESLQQ--VVQSQRE 1422
K+K+ +E LE++ ++++ + + V E QQ + +E
Sbjct: 808 G---KIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQE 864
Query: 1423 VTEVL-----QEATCKIAAQQSETARLTTDAARQ-ICEMAELTRTHISDAVV-----ASG 1471
+ +L Q T K ++ E T Q + E E + H+ + AS
Sbjct: 865 LQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASS 924
Query: 1472 AP----LAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYD 1527
A L I+ + L L+ R E+D S + L ++ K Q
Sbjct: 925 ASQFEELEIVLKEKENELKRLEAMLKER-ESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ 983
Query: 1528 SYSESSGYKNHDRRSSSGSSRQ--------ESPSVPSCKENEKKLNGEKIESSIDEQVQT 1579
+Y ++S + H+ S R+ E S+ E+++K N + E + +
Sbjct: 984 NYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEAL 1043
Query: 1580 AADDSLRSDSVPSLPDEKDSTSIATEYSLK------------------------FDESMT 1615
A+ + + D V E+ A E K F++
Sbjct: 1044 ASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAK 1103
Query: 1616 E--------DEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNM 1667
E +E++ + E H +E + ++ E +K S +E N
Sbjct: 1104 ECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEEN- 1162
Query: 1668 PFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHL 1727
K+ +++ + ++M+++ SS L + K ++ L +++HL
Sbjct: 1163 ----------KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENK---DIENLRREREHL 1209
Query: 1728 R---DKGEDDKMPPLR--KKQRGLLLRLQQEKAEIKRLQEA-NKAARKERQLILKQQEEI 1781
+K E ++ + ++ + LL LQ K+L ++ ++A R+ +L L + +
Sbjct: 1210 EMELEKAEMERSTYVTEVRELKDLLTELQ------KKLDDSYSEAVRQNEELNLLKAQLN 1263
Query: 1782 EKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSS 1841
E + + + E+ K AG+ S + + + G T + S SSE +
Sbjct: 1264 ETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKET 1323
Query: 1842 IMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEEL 1875
+ L + +++ ++ L Q+L + ++H + L
Sbjct: 1324 MSVSLNQTVTQL-QQLLQAVNQQLTKEKEHYQVL 1356
Score = 45.4 bits (106), Expect = 9e-04
Identities = 188/1080 (17%), Positives = 416/1080 (38%), Gaps = 148/1080 (13%)
Query: 1901 DKELIKPKTPKKELEDQRTEQKEIAS-----EEESPVPLYSHLNSESSIPEELGSPAVEY 1955
+++LI KT KK+ E ++ ++KEI + + VP L+ ++ ++ +P
Sbjct: 44 EQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLN 103
Query: 1956 V--PSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHR 2013
V S S+ + + + EE + +E ++S P K P T S +
Sbjct: 104 VVETSSSVRERKKKEKKQKPVLEEQVI-KESDASKIPGKKVEPVPVTKQPTPPSEAAA-- 160
Query: 2014 TGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKK 2073
S + +S+ SD D + + + ++ + + K+
Sbjct: 161 ------------------SKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQ 202
Query: 2074 E----QKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDL----ETSPTAKP-QIKT 2124
E +KK ++ K + + + L +I + S + E KP Q++
Sbjct: 203 ESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEG 262
Query: 2125 LSSASEKPKIKPLTPLHRSETA-----KNWKSLTESERSRGSLESIAEHVDASLSGSERS 2179
+ + K K+K T +E + K++ SE + + + + + +
Sbjct: 263 IQKSGTK-KLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKK 321
Query: 2180 VSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSS-RKIREESGDSLE--NVPALHLLKELN 2236
S+ L+ ++ E D + + + +++ +E E NV + +
Sbjct: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIG 381
Query: 2237 ATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSE 2296
+ ++ K+ S ++++ ++++ ++++ + + ++ +L V +++
Sbjct: 382 TLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAV--SNTTNQ 439
Query: 2297 ILSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNT 2356
+ SK+ L+ +++D L E K+ ++ +E ++ + Q + E +
Sbjct: 440 LESKQSAELNK--LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAAT-QLKVQLQEAERR 496
Query: 2357 KEKDLSW-----SEHLFAPKEIP---YSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKD 2408
E+ S+ +EH A +++ +++ EV S +++ L L+ L +
Sbjct: 497 WEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES 556
Query: 2409 SQSCRDKPQPMRSSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSK 2468
Q +K + ++ E +E L + HS + + S + L +
Sbjct: 557 EQKRVNKEESLQMQVQDIL------EQNEALKAQIQQFHSQIAAQT-----SASVLAEEL 605
Query: 2469 ERSDVEHEQQVTESP-SLAS-----VPTADELFDFHIGDRVLIGNVQPGILRFKGETSFA 2522
+ E ++Q+ ++ SLAS +EL D + +L VQ K +
Sbjct: 606 HKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ------KLQALAN 659
Query: 2523 KGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDC 2582
+ A EL+K + + D I E + +H I +++ +N+
Sbjct: 660 EQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH----------EISNKMEEFKILNDQNKA 709
Query: 2583 YSDE--RYQCYNQEQNDTEGPKDREKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNV 2640
E + Q EQ + + + EK + E ++ L +V ++ +ET +
Sbjct: 710 LKSEVQKLQTLVSEQPNKDVVEQMEKCIQEK--DEKLKTVEEL-----------LETGLI 756
Query: 2641 QDISGVLEAHVHQQSSVDSQISSKENKDLISDATEKVSIAAEDDTLDNTFSEELEKQQQF 2700
Q + E + + ++ +KE +DL + ++VS A+ EEL+K
Sbjct: 757 QVATKEEELNAIR---TENSSLTKEVQDLKAKQNDQVSFAS--------LVEELKK---V 802
Query: 2701 TEEEDNLYAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLK 2760
E+D E L LL + +EK + + + +E+ QLEK L+
Sbjct: 803 IHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLS----- 857
Query: 2761 VFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSE 2820
+ V +LQ + K ++E++ L ++ Q+++E++ S+
Sbjct: 858 --ITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVA 915
Query: 2821 LEDEKEEISSPDMCPRPESPVFGASGQEELAKRLAELELSREFLSALGDDQDWFDEDFGL 2880
+ KE S AS EEL L E E + L A+ ++ + L
Sbjct: 916 QHNLKEASS--------------ASQFEELEIVLKEKENELKRLEAMLKER-----ESDL 956
Query: 2881 SSSHKIQKNKAEETIVPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKEL 2940
SS ++ ++ +E + ++ +++ QQ + + P E ++++ E W EL
Sbjct: 957 SSKTQLLQDVQDENKL-FKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNEL 1015
Score = 38.5 bits (88), Expect = 0.10
Identities = 97/459 (21%), Positives = 193/459 (42%), Gaps = 65/459 (14%)
Query: 2608 VSEYFYEKSLPSVNDIEAS-VNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKEN 2666
VS+ E+ L + + E VN+ SL+++ ++ + + L+A + Q SQI+++ +
Sbjct: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQ---FHSQIAAQTS 597
Query: 2667 KDLISDATEKVSIAAEDDTLDNTF-SEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTR 2725
++++ KV IA +D + T S E+ + ++EE+ K + LL
Sbjct: 598 ASVLAEELHKV-IAEKDKQIKQTEDSLASERDRLTSKEEE-------LKDIQNMNFLLKA 649
Query: 2726 EKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSN 2785
E +L+A NE+ + +LEK+ V+VKD +L + + + ++
Sbjct: 650 EVQKLQA----LANEQAAAAHELEKMQ------QSVYVKDDKIRLLEEQLQHEISNKMEE 699
Query: 2786 QELLGDDQK--KVTPQDLSQNVEEQSPSISGCFLSSELEDEKEEISSPDMCPRPESPVFG 2843
++L D K K Q L V EQ K+ + + C + +
Sbjct: 700 FKILNDQNKALKSEVQKLQTLVSEQ--------------PNKDVVEQMEKCIQEKDEKL- 744
Query: 2844 ASGQEELAKRLAELELSREFLSALGDDQDWFDEDFGLSSSHKIQKNKAEE----TIVPLM 2899
+ +E L L ++ E L+A+ + S + ++Q KA++ + L+
Sbjct: 745 KTVEELLETGLIQVATKEEELNAIRTENS--------SLTKEVQDLKAKQNDQVSFASLV 796
Query: 2900 AEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKE----LGHDLHSISI-PTKLL 2954
E K+V + + +V E + V N + + K+ L ++ ++ + + L
Sbjct: 797 EELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQL 856
Query: 2955 GCASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMKPCR-INSSYFRRVK 3013
SK ++++ K K+ + K + EE E N W++ + N S V+
Sbjct: 857 SITSKVQELQNLLKG--KEEQMNTMKAVLEE--KEKDLANTGKWLQDLQEENESLKAHVQ 912
Query: 3014 N--PNNLDEIKSFIASEVLKLFSLKKEPNHKTDWQKMMK 3050
+NL E S E L++ LK++ N + M+K
Sbjct: 913 EVAQHNLKEASSASQFEELEIV-LKEKENELKRLEAMLK 950
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 77.8 bits (190), Expect = 2e-13
Identities = 201/1012 (19%), Positives = 403/1012 (39%), Gaps = 121/1012 (11%)
Query: 1477 LYDHQRQHLP-DFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGY 1535
L++ + +P DF E D+ +P V L+ + + + +K E
Sbjct: 72 LHESDSESVPRDFKLSDALAVEDDQVAP-VPLNVVETSSSVRERKKKEKKQKPVLEEQVI 130
Query: 1536 KNHDRRSSSGSSRQ-----ESPSVPSCKENEKKLNGEKIESS----IDEQVQTAADDSLR 1586
K D G + + P+ PS KK G+K + D++V+T S R
Sbjct: 131 KESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKR 190
Query: 1587 SDSVPSLPDEK-DSTSIATEYSLKFDES----MTEDEIEEQSFRSLLPSESH-----RRF 1636
+++P + K +S S + S K ++ + E I ++ L+ + +R
Sbjct: 191 QEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKRE 250
Query: 1637 NMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAA 1696
++ + + +++ +K T KE + F F + + E+E A
Sbjct: 251 VIDLLKPDQVEGIQKSGTKKLKTETDKE------NAEVKFKDFLLSLKTMMFSEDE--AL 302
Query: 1697 HQSSLLRLR----EKALKEKTKAELAWLEHQ----KKHLRDKGEDDKMPPLRKKQRGLLL 1748
LL+ + + ALK+ +K EL L HQ K L ED R KQ +
Sbjct: 303 CVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM 362
Query: 1749 RLQQEKAE--IKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLDSH 1806
++E++ I R+++ KE + Q +I Q T ++Q K + E ++++
Sbjct: 363 MTEKERSNVVITRMKDRIGTLEKEHNVF---QNKIHVSYQETQQMQMKFQQVRE-QMEAE 418
Query: 1807 SDDDTKDN----KATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKRE 1862
++N A S LE++ S+E + + Q ++ + + EK K +
Sbjct: 419 IAHLKQENGILRDAVSNTTNQLESKQ-------SAELNKLRQDYARLVNELTEK-TGKLQ 470
Query: 1863 QKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTEQK 1922
Q+ +Q++ + + K +L +EAE R E Q+ I+ +T + E Q + K
Sbjct: 471 QEEVQKKNAEQAATQLKVQL--QEAERRWEEVQSY-------IRKRTAEHEAAQQDLQSK 521
Query: 1923 EIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQ 1982
+A E E L+S L ++L ++ + SE + S + Q
Sbjct: 522 FVAKENEVQ-SLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQV--------Q 572
Query: 1983 ELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSE 2042
++ K + + + ++ Q S+ + H I +++SL+ +
Sbjct: 573 DILEQNEALKAQIQQFHSQIAAQTSASV---LAEELHKVIAEKDKQIKQTEDSLASERDR 629
Query: 2043 TTSDQS---DIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDE 2099
TS + DI+ LK E++K +++ N EQ E K Q++ +K +
Sbjct: 630 LTSKEEELKDIQNMNFLLKAEVQKLQALAN----EQAAAAHELEKMQQSVYVKD-DKIRL 684
Query: 2100 FIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSR 2159
++ + E+S +E Q K L S +K + ++ + K + E +
Sbjct: 685 LEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKL 744
Query: 2160 GSLESIAEH--VDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIRE 2217
++E + E + + E + S+ K V + ++ D + + ++ +K+
Sbjct: 745 KTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIH 804
Query: 2218 ESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSK 2277
E +++V L + L ++ + D K + K EI ++ K ++ I +
Sbjct: 805 EKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQE 864
Query: 2278 -----EGKSDVL--LKLVLEQGDSSEILSKK---DLPLDSENVQKDLVGLAIENLHKS-- 2325
+GK + + +K VLE+ + + K DL ++E+++ + +A NL ++
Sbjct: 865 LQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASS 924
Query: 2326 ---------------------EEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWS 2364
E MLKER+SD + + +Q +D ++ ++ + L
Sbjct: 925 ASQFEELEIVLKEKENELKRLEAMLKERESDLS-SKTQLLQDVQDENKLFKSQIEQLKQQ 983
Query: 2365 EHLFAPKEIPYSEDFEV-SSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDK 2415
+ A P+ E +V S +KEIS + D ++ RK + R+K
Sbjct: 984 NYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREK 1035
Score = 57.4 bits (137), Expect = 2e-07
Identities = 254/1334 (19%), Positives = 518/1334 (38%), Gaps = 239/1334 (17%)
Query: 1309 ENMAPIPGSKRFSPAGLHHRMAAELSYLNAIEESVRQLSDVERVRG-----ISLAQQ--- 1360
+ +AP+P + + + + R E +EE V + SD ++ G + + +Q
Sbjct: 95 DQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTP 154
Query: 1361 ESVSLAQIIKAQQQRHERDL--------ALLKLKAEQEAL----ESQRQLEETRNKAAQ- 1407
S + A K Q++ + L+ QEAL E++++ + KA+
Sbjct: 155 PSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSK 214
Query: 1408 -------------VHAESL--------QQVVQSQREVTEVLQEATCKIAAQQSETARLTT 1446
+HA + V +REV ++L+ + Q+S T +L T
Sbjct: 215 KQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVE-GIQKSGTKKLKT 273
Query: 1447 DAARQICE----------------------MAELTRTH---ISDAVVASGAPLAILYDHQ 1481
+ ++ E + +L + I DA+ S HQ
Sbjct: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQ 333
Query: 1482 RQH--------------LPDFVKQLRTRTETDRKSPSVSLSQSKE--GTLDSKHQKY-SA 1524
Q D KQL T+++ +V +++ K+ GTL+ +H + +
Sbjct: 334 LQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK 393
Query: 1525 SYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQVQTAADDS 1584
+ SY E+ + + + E+ +EN + ++ E Q+A +
Sbjct: 394 IHVSYQET---QQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK 450
Query: 1585 LRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRSLLP--SESHRRFN----- 1637
LR D + + TE + K + + + EQ+ L E+ RR+
Sbjct: 451 LRQDYARLVNE-------LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSY 503
Query: 1638 MEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSF-SKFTMEMVRQYMKEEEMRAA 1696
+ KR H+ + ++ + ++ E+ S D+ SK +E + E E +
Sbjct: 504 IRKRTAEHEAAQQDL--QSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRV 561
Query: 1697 HQSSLLRLREKALKEKTKAELAWLEH---------------QKKHLRDKGEDDKMPPLRK 1741
++ L+++ + + E+ +A A ++ ++ H +D ++
Sbjct: 562 NKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTED 621
Query: 1742 KQRGLLLRLQQEKAEIKRLQEAN---KAARKERQLILKQQ----EEIEKIRQTTIKLQEK 1794
RL ++ E+K +Q N KA ++ Q + +Q E+EK++Q+ +K
Sbjct: 622 SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 681
Query: 1795 LKSAGESKLDSHSDDDTK------DNKATSPGPTDLETRSPSPISISSSETSSIMQKLKK 1848
++ E S+ + NKA L+T +S ++++++K
Sbjct: 682 IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQT------LVSEQPNKDVVEQMEK 735
Query: 1849 MRSRMDEKFLTKR---EQKLMQRRQHAEELLEWKRR-----LDAEEAEIRQMEKQALAAW 1900
DEK T E L+Q EEL + + ++ + +Q ++ + A+
Sbjct: 736 CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASL 795
Query: 1901 DKELIKPKTPK----KELED-QRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEY 1955
+EL K K K +E+ E ++A++E++ L + ++ EE+G+ +E
Sbjct: 796 VEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEI---KALKEEIGNVQLEK 852
Query: 1956 VPSESI------------GQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVS 2003
SI G+E+ + ++L E+ ++ ++T L +
Sbjct: 853 AQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEK----EKDLANTGKWLQDLQE------ 902
Query: 2004 KQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRK 2063
+ ES K + Q +L S + E L + E ++ +E ++ + +L
Sbjct: 903 ENESLKAHVQEVAQHNLKEASSASQF----EELEIVLKEKENELKRLEAMLKERESDLSS 958
Query: 2064 RKSVVNQLKKEQK--KRQKERLKAQEASLIKQLESYDEFIK---KTEAELS---QDLETS 2115
+ ++ ++ E K K Q E+LK Q ++E +K + E E+S +L++
Sbjct: 959 KTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSL 1018
Query: 2116 PTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSG 2175
A + ++ + + + L +E K S+ + +E++ L
Sbjct: 1019 KDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKK 1078
Query: 2176 SERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPAL-HLLKE 2234
VS S +Y + ++ ++ + ++ + SG E V L H LKE
Sbjct: 1079 LFPKVSVPSNLSYGEWLHGFEKKAKECMAGT------------SGS--EEVKVLEHKLKE 1124
Query: 2235 LNATSRILDMSDGKVGESSKKSEIKEIE--YTKLKKSKIEDAFSKEGKSDVLLKLVLEQG 2292
+ +L + K KS + E E KL++S ++ + K D K ++Q
Sbjct: 1125 ADEMHTLLQLECEKY-----KSVLAETEGILQKLQRSVEQEENKWKVKVDESHK-TIKQM 1178
Query: 2293 DSSEILSKKDLP-LDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIH 2351
SS S+++L L SEN KD IENL + E L+ +M S + +++
Sbjct: 1179 QSSFTSSEQELERLRSEN--KD-----IENLRREREHLEMELEKAEMERSTYVTEVRELK 1231
Query: 2352 EQKNTKEKDL--SWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDS 2409
+ +K L S+SE + ++ E++ K +++ L K E + + D
Sbjct: 1232 DLLTELQKKLDDSYSEAV--------RQNEELNLLKAQLNETLTKLRTEQNERQKVAGDL 1283
Query: 2410 QSCRDKPQPMRS---STSGATSFGSNEEIS---ECLSEKSLSIHSNVHSDRLLELKSPTE 2463
+ + ++S +G T+ N ++S E ++++S+ N +L +L
Sbjct: 1284 HKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVN 1343
Query: 2464 LMKSKERSDVEHEQ 2477
+KE+ EH Q
Sbjct: 1344 QQLTKEK---EHYQ 1354
Score = 49.7 bits (117), Expect = 5e-05
Identities = 128/694 (18%), Positives = 265/694 (38%), Gaps = 111/694 (15%)
Query: 1262 SQKSLQFDVAGTSSERSKSSVMP-PTITGFKPNAPLTDLNPAASRTTTENMAPIPGSKRF 1320
S K +F + ++ KS V T+ +PN + + + E + + +
Sbjct: 694 SNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTV---EEL 750
Query: 1321 SPAGLHHRMAAELSYLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQR-HERD 1379
GL ++A + LNAI L+ + V+ + Q + VS A +++ ++ HE+D
Sbjct: 751 LETGLI-QVATKEEELNAIRTENSSLT--KEVQDLKAKQNDQVSFASLVEELKKVIHEKD 807
Query: 1380 LALLKLKAEQEALESQ---------------RQLEETRNKAAQVHAESLQQ--VVQSQRE 1422
K+K+ +E LE++ ++++ + + V E QQ + +E
Sbjct: 808 G---KIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQE 864
Query: 1423 VTEVL-----QEATCKIAAQQSETARLTTDAARQ-ICEMAELTRTHISDAVV-----ASG 1471
+ +L Q T K ++ E T Q + E E + H+ + AS
Sbjct: 865 LQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASS 924
Query: 1472 AP----LAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDSKHQKYSASYD 1527
A L I+ + L L+ R E+D S + L ++ K Q
Sbjct: 925 ASQFEELEIVLKEKENELKRLEAMLKER-ESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ 983
Query: 1528 SYSESSGYKNHDRRSSSGSSRQ--------ESPSVPSCKENEKKLNGEKIESSIDEQVQT 1579
+Y ++S + H+ S R+ E S+ E+++K N + E + +
Sbjct: 984 NYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEAL 1043
Query: 1580 AADDSLRSDSVPSLPDEKDSTSIATEYSLK------------------------FDESMT 1615
A+ + + D V E+ A E K F++
Sbjct: 1044 ASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAK 1103
Query: 1616 E--------DEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNM 1667
E +E++ + E H +E + ++ E +K S +E N
Sbjct: 1104 ECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEEN- 1162
Query: 1668 PFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHL 1727
K+ +++ + ++M+++ SS L + K ++ L +++HL
Sbjct: 1163 ----------KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENK---DIENLRREREHL 1209
Query: 1728 R---DKGEDDKMPPLR--KKQRGLLLRLQQEKAEIKRLQEA-NKAARKERQLILKQQEEI 1781
+K E ++ + ++ + LL LQ K+L ++ ++A R+ +L L + +
Sbjct: 1210 EMELEKAEMERSTYVTEVRELKDLLTELQ------KKLDDSYSEAVRQNEELNLLKAQLN 1263
Query: 1782 EKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSS 1841
E + + + E+ K AG+ S + + + G T + S SSE +
Sbjct: 1264 ETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKET 1323
Query: 1842 IMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEEL 1875
+ L + +++ ++ L Q+L + ++H + L
Sbjct: 1324 MSVSLNQTVTQL-QQLLQAVNQQLTKEKEHYQVL 1356
Score = 45.4 bits (106), Expect = 9e-04
Identities = 188/1080 (17%), Positives = 416/1080 (38%), Gaps = 148/1080 (13%)
Query: 1901 DKELIKPKTPKKELEDQRTEQKEIAS-----EEESPVPLYSHLNSESSIPEELGSPAVEY 1955
+++LI KT KK+ E ++ ++KEI + + VP L+ ++ ++ +P
Sbjct: 44 EQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLN 103
Query: 1956 V--PSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHR 2013
V S S+ + + + EE + +E ++S P K P T S +
Sbjct: 104 VVETSSSVRERKKKEKKQKPVLEEQVI-KESDASKIPGKKVEPVPVTKQPTPPSEAAA-- 160
Query: 2014 TGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKK 2073
S + +S+ SD D + + + ++ + + K+
Sbjct: 161 ------------------SKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQ 202
Query: 2074 E----QKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDL----ETSPTAKP-QIKT 2124
E +KK ++ K + + + L +I + S + E KP Q++
Sbjct: 203 ESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEG 262
Query: 2125 LSSASEKPKIKPLTPLHRSETA-----KNWKSLTESERSRGSLESIAEHVDASLSGSERS 2179
+ + K K+K T +E + K++ SE + + + + + +
Sbjct: 263 IQKSGTK-KLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKK 321
Query: 2180 VSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSS-RKIREESGDSLE--NVPALHLLKELN 2236
S+ L+ ++ E D + + + +++ +E E NV + +
Sbjct: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIG 381
Query: 2237 ATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSE 2296
+ ++ K+ S ++++ ++++ ++++ + + ++ +L V +++
Sbjct: 382 TLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAV--SNTTNQ 439
Query: 2297 ILSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNT 2356
+ SK+ L+ +++D L E K+ ++ +E ++ + Q + E +
Sbjct: 440 LESKQSAELNK--LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAAT-QLKVQLQEAERR 496
Query: 2357 KEKDLSW-----SEHLFAPKEIP---YSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKD 2408
E+ S+ +EH A +++ +++ EV S +++ L L+ L +
Sbjct: 497 WEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES 556
Query: 2409 SQSCRDKPQPMRSSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSK 2468
Q +K + ++ E +E L + HS + + S + L +
Sbjct: 557 EQKRVNKEESLQMQVQDIL------EQNEALKAQIQQFHSQIAAQT-----SASVLAEEL 605
Query: 2469 ERSDVEHEQQVTESP-SLAS-----VPTADELFDFHIGDRVLIGNVQPGILRFKGETSFA 2522
+ E ++Q+ ++ SLAS +EL D + +L VQ K +
Sbjct: 606 HKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ------KLQALAN 659
Query: 2523 KGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDC 2582
+ A EL+K + + D I E + +H I +++ +N+
Sbjct: 660 EQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH----------EISNKMEEFKILNDQNKA 709
Query: 2583 YSDE--RYQCYNQEQNDTEGPKDREKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNV 2640
E + Q EQ + + + EK + E ++ L +V ++ +ET +
Sbjct: 710 LKSEVQKLQTLVSEQPNKDVVEQMEKCIQEK--DEKLKTVEEL-----------LETGLI 756
Query: 2641 QDISGVLEAHVHQQSSVDSQISSKENKDLISDATEKVSIAAEDDTLDNTFSEELEKQQQF 2700
Q + E + + ++ +KE +DL + ++VS A+ EEL+K
Sbjct: 757 QVATKEEELNAIR---TENSSLTKEVQDLKAKQNDQVSFAS--------LVEELKK---V 802
Query: 2701 TEEEDNLYAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLK 2760
E+D E L LL + +EK + + + +E+ QLEK L+
Sbjct: 803 IHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLS----- 857
Query: 2761 VFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSE 2820
+ V +LQ + K ++E++ L ++ Q+++E++ S+
Sbjct: 858 --ITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVA 915
Query: 2821 LEDEKEEISSPDMCPRPESPVFGASGQEELAKRLAELELSREFLSALGDDQDWFDEDFGL 2880
+ KE S AS EEL L E E + L A+ ++ + L
Sbjct: 916 QHNLKEASS--------------ASQFEELEIVLKEKENELKRLEAMLKER-----ESDL 956
Query: 2881 SSSHKIQKNKAEETIVPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKEL 2940
SS ++ ++ +E + ++ +++ QQ + + P E ++++ E W EL
Sbjct: 957 SSKTQLLQDVQDENKL-FKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNEL 1015
Score = 38.5 bits (88), Expect = 0.10
Identities = 97/459 (21%), Positives = 193/459 (42%), Gaps = 65/459 (14%)
Query: 2608 VSEYFYEKSLPSVNDIEAS-VNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKEN 2666
VS+ E+ L + + E VN+ SL+++ ++ + + L+A + Q SQI+++ +
Sbjct: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQ---FHSQIAAQTS 597
Query: 2667 KDLISDATEKVSIAAEDDTLDNTF-SEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTR 2725
++++ KV IA +D + T S E+ + ++EE+ K + LL
Sbjct: 598 ASVLAEELHKV-IAEKDKQIKQTEDSLASERDRLTSKEEE-------LKDIQNMNFLLKA 649
Query: 2726 EKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSN 2785
E +L+A NE+ + +LEK+ V+VKD +L + + + ++
Sbjct: 650 EVQKLQA----LANEQAAAAHELEKMQ------QSVYVKDDKIRLLEEQLQHEISNKMEE 699
Query: 2786 QELLGDDQK--KVTPQDLSQNVEEQSPSISGCFLSSELEDEKEEISSPDMCPRPESPVFG 2843
++L D K K Q L V EQ K+ + + C + +
Sbjct: 700 FKILNDQNKALKSEVQKLQTLVSEQ--------------PNKDVVEQMEKCIQEKDEKL- 744
Query: 2844 ASGQEELAKRLAELELSREFLSALGDDQDWFDEDFGLSSSHKIQKNKAEE----TIVPLM 2899
+ +E L L ++ E L+A+ + S + ++Q KA++ + L+
Sbjct: 745 KTVEELLETGLIQVATKEEELNAIRTENS--------SLTKEVQDLKAKQNDQVSFASLV 796
Query: 2900 AEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKE----LGHDLHSISI-PTKLL 2954
E K+V + + +V E + V N + + K+ L ++ ++ + + L
Sbjct: 797 EELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQL 856
Query: 2955 GCASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMKPCR-INSSYFRRVK 3013
SK ++++ K K+ + K + EE E N W++ + N S V+
Sbjct: 857 SITSKVQELQNLLKG--KEEQMNTMKAVLEE--KEKDLANTGKWLQDLQEENESLKAHVQ 912
Query: 3014 N--PNNLDEIKSFIASEVLKLFSLKKEPNHKTDWQKMMK 3050
+NL E S E L++ LK++ N + M+K
Sbjct: 913 EVAQHNLKEASSASQFEELEIV-LKEKENELKRLEAMLK 950
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 77.4 bits (189), Expect = 2e-13
Identities = 206/1142 (18%), Positives = 447/1142 (39%), Gaps = 156/1142 (13%)
Query: 1336 LNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALL---KLKAEQEAL 1392
L+ +EE + QL D + Q++ L +++ + + E +L+A E L
Sbjct: 387 LSQLEEHLSQLQD-------NPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEML 439
Query: 1393 ESQRQLEETRNKAAQVHAESLQQVVQS-----QREVTEVLQEATCKIAAQQSETARLTTD 1447
E++R +E + A + H E +Q + S Q ++ + Q A Q+ ARLT
Sbjct: 440 ETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499
Query: 1448 AARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSL 1507
A E+ L T Q Q L +Q + + + + +L
Sbjct: 500 VASLTSELTTLNAT----------------IQQQDQELAGLKQQAKEK----QAQLAQTL 539
Query: 1508 SQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGE 1567
Q ++ + +HQ S SS Q+ V +E ++ + +
Sbjct: 540 QQQEQASQGLRHQVEQLS----------------SSLKQKEQQLKEVAEKQEATRQDHAQ 583
Query: 1568 KIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRSL 1627
++ ++ +E+ + SLR E+D+ E K E + EI +Q +
Sbjct: 584 QLATAAEER-----EASLR---------ERDAALKQLEALEK--EKAAKLEILQQQLQVA 627
Query: 1628 LPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMVRQY 1687
+ + ++ + + + + + + TA++ Q ++ +++ +
Sbjct: 628 NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHE---AQAQVAELELQLRSEQ 684
Query: 1688 MKE-EEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDK--MPPLRKKQR 1744
K E+ R A + L+ + +ALKE K LE +K+ D E+ + + L+ + R
Sbjct: 685 QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETR 744
Query: 1745 GLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLD 1804
L+ +Q K E K L+E +A RK + L+Q E + ++ + A + +
Sbjct: 745 SLV---EQHKRERKELEE-ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAE 800
Query: 1805 SHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQK 1864
S + K+ A D + ++ + ++ ++ +K R + E ++K
Sbjct: 801 SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEA-----KEK 855
Query: 1865 LMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEI 1924
+ H+E ++ ++ E+ ++ A + K +K +D T Q+++
Sbjct: 856 VAGIESHSE------LQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKM 909
Query: 1925 ASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICS--- 1981
A+ + L + L ++ +E S + P+ + G QP + CS
Sbjct: 910 AATSKEVARLET-LVRKAGEQQETASRELVKEPARA-GDRQPEWLEEQ--QGRQFCSTQA 965
Query: 1982 --QELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMT 2039
Q +E + L + ++ + + + R + + + + + +D +L
Sbjct: 966 ALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKA 1025
Query: 2040 QSETTSDQSDIEGRIRALKDELRKRKSVVNQL------KKEQKKRQKERLKAQEASLIKQ 2093
++++E R++ +E R + + + +KE K ++ +L+ EA+ IK+
Sbjct: 1026 A------RAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKE 1079
Query: 2094 LESYDEFIKKTEAELSQDLE---------------TSPTAKPQIKTLSSASEKPKIKPLT 2138
LE + +K+ + +L++ + T PT P+++ L +E K++
Sbjct: 1080 LEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTG-PKLEAL--RAEVSKLEQQC 1136
Query: 2139 PLHRSETAKNWKSLTESERSRGSLESIAEHVDASL---------SGSERSVSERSLSAYA 2189
+ + +SL SR +S E + L S S + ++R L+A+
Sbjct: 1137 QKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFR 1196
Query: 2190 KRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKV 2249
+V + ++++ R + + SLE ++ + L ++ +
Sbjct: 1197 TKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVM 1256
Query: 2250 GESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSKKDLPLDSEN 2309
ES K +++E +L+ + E A + ++ L E E K+ + SEN
Sbjct: 1257 AESEKSQKLEE----RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVA--SEN 1310
Query: 2310 VQKDLVGLAIENLHKSEEMLKERQSDQD--MNHSPNIQSGKDIHEQKNTKEKDLSWSEHL 2367
++++L A ++EE+ +E ++ Q+ + + + H +L ++HL
Sbjct: 1311 LRQELTSQA----ERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHL 1366
Query: 2368 F-------APKEIPYSEDFEVS-SFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPM 2419
A E + E+ E S + AEL + E+ L+ LR+ Q +
Sbjct: 1367 CQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQL 1426
Query: 2420 RS 2421
R+
Sbjct: 1427 RA 1428
Score = 61.6 bits (148), Expect = 1e-08
Identities = 137/667 (20%), Positives = 257/667 (38%), Gaps = 115/667 (17%)
Query: 1674 DSFSKFTMEMV-RQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGE 1732
+ SK T E + +Q E+E+ AA Q +K L+EK + L ++HL
Sbjct: 346 EEHSKATQEWLEKQAQLEKELSAALQD------KKCLEEKNEILQGKLSQLEEHLSQL-- 397
Query: 1733 DDKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQ 1792
D P + + G +L+L+ K QEA A QL Q +++
Sbjct: 398 QDNPPQEKGEVLGDVLQLETLK------QEAATLAANNTQL------------QARVEML 439
Query: 1793 EKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSR 1852
E + E+KL + ++ + S TDL+ S IS S + Q + +R
Sbjct: 440 ETERGQQEAKLLAERGHFEEEKQQLSSLITDLQ----SSISNLSQAKEELEQASQAHGAR 495
Query: 1853 MDEKF------LTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIK 1906
+ + LT + Q+ Q L + + A+ A+ Q ++QA ++ +
Sbjct: 496 LTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQ 555
Query: 1907 PKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQP 1966
+ K+ E Q KE+A ++E+ + ++L + A E S+ +
Sbjct: 556 LSSSLKQKEQQL---KEVAEKQEA---------TRQDHAQQLATAAEER--EASLRERDA 601
Query: 1967 GSPDHSILTEEMICSQE-LESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSH 2025
L +E E L+ + + + TSV++ + K
Sbjct: 602 ALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAE-------------- 647
Query: 2026 QHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKA 2085
S E L +Q + + ++ L+ +LR ++QK +KER+
Sbjct: 648 ---LSRKVEELQACVETARQEQHEAQAQVAELELQLRS---------EQQKATEKERVAQ 695
Query: 2086 QEASLIKQLESYDEFIKKTEAELSQDLETSPTA-KPQIKTLSSASEKPKIKPLTPLHRSE 2144
++ L +QL++ E +K T+ L ++ + A + Q + +S K + + L H+ E
Sbjct: 696 EKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISEL--KAETRSLVEQHKRE 753
Query: 2145 TAKNWKSLTESERSRGSLES----IAEHVDASLSGSERSVSERSLSAY---------AKR 2191
K L E R LE+ + E A R ++E + + K
Sbjct: 754 R----KELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKE 809
Query: 2192 VNEWDSRTED-----------FQTPSPVLRSS-RKIREESGDSLENVPALHLLKELNATS 2239
V W R ED FQ L+ K R+E ++ E V + EL +
Sbjct: 810 VAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISR 869
Query: 2240 RILDMSD--GKVGESSKKSEIKEIEYTKLKK--SKIEDAFSKEGKSDVLLK-LVLEQGDS 2294
+ ++++ + + ++ + KE+ KL S +++ + K L+ LV + G+
Sbjct: 870 QQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQ 929
Query: 2295 SEILSKK 2301
E S++
Sbjct: 930 QETASRE 936
Score = 42.4 bits (98), Expect = 0.007
Identities = 69/307 (22%), Positives = 126/307 (41%), Gaps = 42/307 (13%)
Query: 2651 VHQQSSVDSQISSKENKDLISDATEKVSIAAEDDTL----DNTFSEELEKQQQFTEEEDN 2706
+ QQ V ++ + EK ++ + + L + E+ E Q Q E E
Sbjct: 620 LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ 679
Query: 2707 LYAE---ASEKLCTPLLDLLTREKNQLEAQL----------KSSLNEEKKSKQQLEKISL 2753
L +E A+EK + + +EK+QL+ QL K SL EEK+ +
Sbjct: 680 LRSEQQKATEK------ERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQ 733
Query: 2754 LTDSLLKVFVKDTVNQLQQIKKTRDEK------IQLSNQEL--LGDDQKKVTPQDLSQNV 2805
S LK + V Q ++ +K +E+ ++ Q+L + +V ++L++ +
Sbjct: 734 RCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAM 793
Query: 2806 EEQSPSISGC-FLSSELEDEKEEISSPDMCPRPESPVFGASGQEELAKRLAELELSREFL 2864
Q + S C L E+ +E + E +GA QE+L E E +R+ L
Sbjct: 794 AAQHTAESECEQLVKEVAAWRERYED----SQQEEAQYGAMFQEQLMTLKEECEKARQEL 849
Query: 2865 SALGDDQDWFDEDFGLSSSHKIQKNKAEETIVPLMAEPKRVTQQPCETLLAVPHTAEEVE 2924
Q+ ++ G+ S ++Q ++ + + L A R QQ E + A+++
Sbjct: 850 ------QEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS 903
Query: 2925 ILVHNAA 2931
L A
Sbjct: 904 TLQEKMA 910
Score = 40.8 bits (94), Expect = 0.021
Identities = 155/844 (18%), Positives = 303/844 (35%), Gaps = 136/844 (16%)
Query: 938 RSPGPKPEGLLAQLCKRQTDSSSSDMQACSQDKAKISLGSSIDSVSEGPLLSEGSLSEEE 997
R+ +PE L Q RQ S+ + +QA ++ + +G+ ++ + + S+G EE
Sbjct: 943 RAGDRQPEWLEEQQ-GRQFCSTQAALQAMEREAEQ--MGNELERLRAALMESQGQQQEER 999
Query: 998 GDQDGQPLLKVAEILKEKEFCPGERNSYEPIKEFQKEAEKFLPLFGHIGGTQSKGPWEEL 1057
G Q+ + VA + +E R + +K A L + + + + L
Sbjct: 1000 GQQERE----VARLTQE-------RGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048
Query: 1058 AKGSPHSVINIFTKSYQLYGKGFEDKLDRGTSTSR-----PLNATATPLSGVSYEDDFVS 1112
+ H++ + GK E RG ++ L T L + +
Sbjct: 1049 QEALAHALT-------EKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
Query: 1113 SPGTGTSTEKKSTLEPHSTLSPQEDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSSTSS 1172
+ G+G +E EP + K + V Q Q A S +
Sbjct: 1102 ASGSGAQSEAAGRTEP----------TGPKLEALRAEVSKLEQQCQKQQEQADSLERSLE 1151
Query: 1173 KGKKGKKEKTEWLDSFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTDST 1232
+ + E+ L++ G + EEKA+ H + + S++ + F + S
Sbjct: 1152 AERASRAERDSALETLQGQL------EEKAQELGHS-QSALASAQRELAAFRTKVQDHSK 1204
Query: 1233 LEDLSGHSVSVSSDKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSSVMPPTITGFKP 1292
ED V+ +GR + + L S ++ + + +S + +
Sbjct: 1205 AEDEWKAQVA----RGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMA--- 1257
Query: 1293 NAPLTDLNPAASRTTTENMAPIPGSKRFSPAGLHHRMAAELSYLNAIEESVRQLSDVERV 1352
S+ E + + + A R A S L +S+R+ ++ +RV
Sbjct: 1258 -------ESEKSQKLEERLRLLQAETASNSA----RAAERSSALREEVQSLREEAEKQRV 1306
Query: 1353 RGISLAQQ------ESVSLAQIIKAQQQRH-ERDLALLKLKAEQ---EALESQ------- 1395
+L Q+ + L Q +KA Q++ +++ AL L+ E +AL S+
Sbjct: 1307 ASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHL 1366
Query: 1396 -RQLEETRNKAAQVHAESLQQ-----------VVQSQREVTEVLQEATCKIAAQQSETAR 1443
+QL+ + A + H E L+Q ++++QRE+ E++ K+A Q+ +
Sbjct: 1367 CQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQ-KVAEQERTAQQ 1425
Query: 1444 LTTDAARQICEMAELTRTH---------ISDAVVASGAPLAILYDHQRQHLPDFVKQLRT 1494
L + A +++ L + H + + L + D R+ + +R
Sbjct: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRA 1485
Query: 1495 RTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQ----E 1550
ET R + +QS L+ KY + E +R+ + Q +
Sbjct: 1486 DAET-RLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQ 1544
Query: 1551 SPSVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKF 1610
+E KKL S + +Q A +S A +
Sbjct: 1545 REQTKQVEELSKKLADSDQASKVQQQKLKAVQ-----------AQGGESQQEAQRLQAQL 1593
Query: 1611 DESMTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFS 1670
+E + +EQ+ H + MEK + H+D ++ + L + ++L
Sbjct: 1594 NELQAQLSQKEQA-------AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENK 1646
Query: 1671 GGQDSFSKFTMEMVRQYM--KEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLR 1728
+ + E+ + + KE E H ++ +R E A + H + LR
Sbjct: 1647 ELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLE-----------AQVAHADQQLR 1695
Query: 1729 DKGE 1732
D G+
Sbjct: 1696 DLGK 1699
Score = 34.3 bits (77), Expect = 2.0
Identities = 67/308 (21%), Positives = 132/308 (42%), Gaps = 42/308 (13%)
Query: 403 QKVAQLSST-----ECRTGSSHLIS--TSSWRDGQKLVKKILGP--APRMEPKEQ-RTAS 452
+K AQL+ T + G H + +SS + ++ +K++ A R + +Q TA+
Sbjct: 530 EKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAA 589
Query: 453 SDRGG--RERTAKSGG-HIGRAESDPRLDVLHRHLQRNSER-----------SRSKSRSE 498
+R RER A E +L++L + LQ +E R K+
Sbjct: 590 EEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELS 649
Query: 499 NNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVELQNQ---- 554
+++L + + +QE++ A +E++ + + Q + Q+ +LQ Q
Sbjct: 650 RKVEELQACVETARQEQHEA-QAQVAELELQ-LRSEQQKATEKERVAQEKDQLQEQLQAL 707
Query: 555 KSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNEE 614
K S V +R D + E IS+ + E R + +Q +R+RK+ EE
Sbjct: 708 KESLKVTKGSLEEEKRRAADAL--EEQQRCISELKA----ETRSLV--EQHKRERKELEE 759
Query: 615 KKAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKTLLEEP 674
++A ++ E + ++L E + +A T+V +E A + E+ + L+++
Sbjct: 760 ERAGRKGLEARLQQLGEAH----QAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRE 815
Query: 675 SHQHVTQE 682
++ QE
Sbjct: 816 RYEDSQQE 823
Score = 33.5 bits (75), Expect = 3.4
Identities = 104/605 (17%), Positives = 235/605 (38%), Gaps = 65/605 (10%)
Query: 1888 EIRQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEE 1947
+I Q + + K+L ++ + ELE + E +++ +E+++ + + ++
Sbjct: 207 DILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLAL--- 263
Query: 1948 LGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQES 2007
+ ++Q SP EE+ ++ S + H K C + ++S
Sbjct: 264 -------------LNEKQAASPLEPKELEEL---RDKNESLTMRLHETLKQCQDLKTEKS 307
Query: 2008 ------SKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDEL 2061
++ S G + H D +T+ + + Q +E + +L
Sbjct: 308 QMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQA-----QL 362
Query: 2062 RKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQ 2121
K S Q KK +++ E L+ + + L + L + + + E+ D+ T K +
Sbjct: 363 EKELSAALQDKKCLEEK-NEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421
Query: 2122 IKTLSSASE--KPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDAS---LSGS 2176
TL++ + + +++ L + AK E + L S+ + +S LS +
Sbjct: 422 AATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQA 481
Query: 2177 ERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRK----IREESGDSLENVPALHLL 2232
+ + + S + A+ + S T + T + ++ + +++++ + + L
Sbjct: 482 KEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKE--KQAQLAQTL 539
Query: 2233 KELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQG 2292
++ S+ L ++ S K+ E + E + +++ +D + L E+
Sbjct: 540 QQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQ-------LATAAEER 592
Query: 2293 DSSEILSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHE 2352
++S L ++D L K L L E K E + ++ Q + S + E
Sbjct: 593 EAS--LRERDAAL------KQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQRE 644
Query: 2353 QKNTKEKDLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSC 2412
+ K E L A E E E + E+ +L + + + + ++
Sbjct: 645 KAELSRK----VEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQL 700
Query: 2413 RDKPQPMRSSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSD 2472
+++ Q ++ S + GS EE ++ +L S+ E +S E K +ER +
Sbjct: 701 QEQLQALKESLK--VTKGSLEEEKRRAAD-ALEEQQRCISELKAETRSLVEQHK-RERKE 756
Query: 2473 VEHEQ 2477
+E E+
Sbjct: 757 LEEER 761
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 77.0 bits (188), Expect = 3e-13
Identities = 306/1571 (19%), Positives = 599/1571 (38%), Gaps = 222/1571 (14%)
Query: 1328 RMAAELSYLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKA 1387
RM A NA++ L++ E+ R +L ++ + AQ+ KA++ E L ++
Sbjct: 632 RMEAAEQARNALQVD---LAEAEKRRE-ALWEKNTHLEAQLQKAEEAGAELQADLRDIQE 687
Query: 1388 EQEALESQRQLEETRNK--AAQVHAESLQQVVQSQREV-TEVLQEATCKIAAQQSETARL 1444
E+E E Q++L E+R++ AA E L Q + Q EV +QE + + + RL
Sbjct: 688 EKE--EIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRL 745
Query: 1445 TTDAARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVK--QLRTRTETDRKS 1502
R ++AE + S + + L++ Q+Q+ V QL + +T ++
Sbjct: 746 QA-VERDRQDLAEQLQGLSSAKELLESS----LFEAQQQNSVIEVTKGQLEVQIQTVTQA 800
Query: 1503 PSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEK 1562
V + + L+ ++ A + + + ++ + +Q++ + +
Sbjct: 801 KEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLRE 860
Query: 1563 KLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDE-IEE 1621
K E+ S +Q A +SL + + E ++ E TE E I+
Sbjct: 861 KWEKER---SWHQQELAKALESLEREKM--------------ELEMRLKEQQTEMEAIQA 903
Query: 1622 QSFRSLLPSES---HRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSK 1678
Q +ES + EK E S +T L T KEL + +
Sbjct: 904 QREEERTQAESALCQMQLETEK---------ERVSLLETLLQTQKEL----ADASQQLER 950
Query: 1679 FTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKA---ELAWLEHQKKHLRDKGEDDK 1735
+M Q +KE+E Q+ L+ ++ LKE + +LA L+ + L DK
Sbjct: 951 LRQDMKVQKLKEQETTGILQTQ-LQEAQRELKEAARQHRDDLAALQEESSSLL----QDK 1005
Query: 1736 MPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQT-TIKLQEK 1794
M L+K+ L +L + + +++ + +E Q + Q+E+E+ + + T+ L EK
Sbjct: 1006 M-DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064
Query: 1795 LKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMD 1854
E +L + D+ + S D++ E S+ M+ L++ +
Sbjct: 1065 -----EQRLLVLQEADSIRQQELSALRQDMQEAQG-----EQKELSAQMELLRQEVKEKE 1114
Query: 1855 EKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKEL 1914
FL + Q L + + + L A+EA+ Q++ ++ ++ + +L
Sbjct: 1115 ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ-----------LRLRSTESQL 1163
Query: 1915 EDQRTEQK--EIASEEESPVPLYSHLNSE-----SSIPEELG----SPAVEYVPSESIGQ 1963
E EQ+ A + LYS L S PE G +P+V + + G
Sbjct: 1164 EALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGA 1223
Query: 1964 EQ--PGSPDHSILTEEMICS--QELESSTSPSKHSLPKSCTSVSK-QESSKGSHRTGGQC 2018
P + L+ E + S +L ++ + V K +E + Q
Sbjct: 1224 RSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQV 1283
Query: 2019 HLPIKSHQHCYSWSDESLSM---TQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQ 2075
H ++ Q S + E S Q+ S+ ++ + +L+ LR+ +L++ +
Sbjct: 1284 HTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRA-----ELQRME 1338
Query: 2076 KKRQKERLKAQEASLIKQLESYDEFIKKTEAE------LSQDLETSPTAKPQIKTLSSAS 2129
+ ++E L+A + +L Q+E + + A+ L +DL T+ +A ++K S
Sbjct: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSAL-KLKNEEVES 1397
Query: 2130 EKPKIKPLTPLHRSETAKN----------WKSLTESERSRGSLESIAEHVDASLSGSERS 2179
E+ + + L + A+ ++L E E +L + ++ + +
Sbjct: 1398 ERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAA 1457
Query: 2180 VSERSLSAYAKRVNEWDSRTEDFQ-----------TPSPVLRSSRKIR---------EES 2219
+ SL KR E D + E Q P V +K+ E+
Sbjct: 1458 LELLSLD-LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKD 1516
Query: 2220 GDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEG 2279
++ NV H L EL ++++ G+V K ++ +E L ++E+ K
Sbjct: 1517 RETQRNV-LEHQLLELEKKDQMIESQRGQV--QDLKKQLVTLECLAL---ELEENHHKME 1570
Query: 2280 KSDVLLKLVLEQGDSSEI-LSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDM 2338
L+K + Q ++ + L+ L L+ + + I +L +L ++D
Sbjct: 1571 CQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQ 1630
Query: 2339 NHSPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFE 2398
+ +++ QK +DL + + + E +V ++ ++ ++D E
Sbjct: 1631 EVKSQREQIEELQRQKEHLTQDLERRDQ----ELMLQKERIQVLEDQRTRQTKILEEDLE 1686
Query: 2399 VSSLLSLRKDSQSCRDKPQPMRSSTS-----GATSFGSNEEISECLSEKSLSIH-SNVHS 2452
LSLR+ + + Q M+ GS E + L +K + H
Sbjct: 1687 -QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHI 1745
Query: 2453 DRLLELKSPTE---------------LMKSKERSDVEHEQQVTESPSLASVPTADELFDF 2497
L ELK E L+ +E+ V +QQ+ E+ +
Sbjct: 1746 HELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQL 1805
Query: 2498 HIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIF 2557
R L Q + + E A+G V+ +K + A+ KE+HG
Sbjct: 1806 DEAQRALAQRDQE-LEALQQEQQQAQGQEERVK-EKADALQGALEQ--AHMTLKERHGEL 1861
Query: 2558 APPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYEKSL 2617
++ + E+E R Q + D + RE+ EK+L
Sbjct: 1862 ----------QDHKEQARRLEEELAVEGRRVQALEEVLGDLRA-ESREQ-------EKAL 1903
Query: 2618 PSVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQSSVDSQISSKENKDLISDATEKV 2677
++ + +++ ++ET +QD +A + ++ + ++ + +
Sbjct: 1904 LALQ--QQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARA 1961
Query: 2678 SIAAEDDTLDNTFSEELEKQQQFTEE-EDNLYAEASEKLCTPLLDLLTREKNQLEAQLKS 2736
A + L + K+Q E+ E + EAS LD QLE L+
Sbjct: 1962 RAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALR- 2020
Query: 2737 SLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKV 2796
+ E + Q L ++ V QLQQ RDE +L +Q+ +++++
Sbjct: 2021 -IQEGEIQDQDLR-------------YQEDVQQLQQALAQRDE--ELRHQQ----EREQL 2060
Query: 2797 TPQDLSQNVEE 2807
+ L+Q V+E
Sbjct: 2061 LEKSLAQRVQE 2071
Score = 57.8 bits (138), Expect = 2e-07
Identities = 168/890 (18%), Positives = 342/890 (38%), Gaps = 95/890 (10%)
Query: 1345 QLSDVER-----VRGISLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALESQR--Q 1397
Q+ D+E R + QE S + I+ Q++ E L+ + ++ L+ +R
Sbjct: 1610 QIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQV 1669
Query: 1398 LEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSETARLTTDAARQICEMAE 1457
LE+ R + ++ E L+Q+ S RE L ++ +++E + + A R E +
Sbjct: 1670 LEDQRTRQTKILEEDLEQIKLSLRERGRELTTQR-QLMQERAEEGKGPSKAQRGSLEHMK 1728
Query: 1458 LTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTLDS 1517
L V + H+ Q L D ++Q S+ LSQ ++ +
Sbjct: 1729 LILRDKEKEVECQQEHI-----HELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVL 1783
Query: 1518 KHQKYSA-SYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQ 1576
+ Q A E S D + + R + + + ++ +++ G+ +E+
Sbjct: 1784 QQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQE--LEALQQEQQQAQGQ------EER 1835
Query: 1577 VQTAAD--DSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHR 1634
V+ AD + +L + E + + +E + + Q+ +L
Sbjct: 1836 VKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLG----- 1890
Query: 1635 RFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMR 1694
+ R + + ++ A+E + QDS+ + + + + E +R
Sbjct: 1891 ----DLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALR 1946
Query: 1695 AA-----HQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLR 1749
A HQ R R +AL+E A L+ +++HL ++ E + L L
Sbjct: 1947 AESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSR--SLEASTATLQAS 2004
Query: 1750 LQQEKAEIKRLQEANKAARKERQ-LILKQQEEIEKIRQTTIKLQEKLKSAGESK--LDSH 1806
L +A ++L+EA + E Q L+ QE++++++Q + E+L+ E + L+
Sbjct: 2005 LDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKS 2064
Query: 1807 SDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLM 1866
++N ++ + E + Q +++++ + +K E +
Sbjct: 2065 LAQRVQENM--------IQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRET 2116
Query: 1867 QRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTEQKEIAS 1926
Q+R + E L + EE ++ + +EL + + ++ E + E +E A
Sbjct: 2117 QQRNNLEALPHSHKTSPMEEQSLKLDSLE--PRLQRELERLQAALRQTEAREIEWREKA- 2173
Query: 1927 EEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELES 1986
++ + L S SS+ E + +S EQ D LT + + L S
Sbjct: 2174 -QDLALSLAQTKASVSSLQEVAMFLQASVLERDS---EQQRLQDELELTRRALEKERLHS 2229
Query: 1987 STSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSD--ESLSMTQSETT 2044
+ S L S+ E G P SW E L +
Sbjct: 2230 PGATSTAELG------SRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLE 2283
Query: 2045 SDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKT 2104
D+S R++ +LR S + Q+++E++K ++E ++A +A +
Sbjct: 2284 IDRS----RLQRHNVQLR---STLEQVERERRKLKREAMRAAQAGSL------------- 2323
Query: 2105 EAELSQDLETSPTAKPQIKTLSS-----ASEKPKIKPLTPLHRSETAKNWKSLTESERSR 2159
E+S+ +SPT + +S A + ++ L E + +T S ++
Sbjct: 2324 --EISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTS 2381
Query: 2160 GSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVL 2209
L + + SL ++ L A +R++E S T+ +P PVL
Sbjct: 2382 RELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDE--SLTQSLTSPGPVL 2429
Score = 50.1 bits (118), Expect = 3e-05
Identities = 217/1177 (18%), Positives = 468/1177 (39%), Gaps = 195/1177 (16%)
Query: 1761 QEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATS-- 1818
Q+A+KA R ++ ++++ ++ +RQ QE + + L D ++ KA
Sbjct: 382 QDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAV-----NLLQQQHDQWEEEGKALRQR 436
Query: 1819 ----PGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAE- 1873
G D + S + L+K R + ++ ++ RR + E
Sbjct: 437 LQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVEL 496
Query: 1874 ----ELLEWKRRLDAEEAEIRQMEKQAL--------AAWDKELIKPKTPKKELEDQ---- 1917
+ + ++ EE + E++ L A + L + T ++ LE
Sbjct: 497 QLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEG 556
Query: 1918 ---RTEQKEI----ASEEESPVPLYSHLNSESSIPEELGSPAVEY-VPSESIGQEQPGSP 1969
R EQ E+ A E+S L S N+ + +L + AV+ +E++ ++ G
Sbjct: 557 ELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLN 616
Query: 1970 DHSILTEE---MICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQ 2026
+ EE +CS+ + ++++L K+ + T HL + +
Sbjct: 617 QQLLQLEEENQSVCSR--MEAAEQARNALQVDLAEAEKRREALWEKNT----HLEAQLQK 670
Query: 2027 HCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKK--EQKKRQKE--- 2081
++E+ + Q++ Q + E + L + ++++ QL++ ++ KRQ+E
Sbjct: 671 -----AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLA 725
Query: 2082 RLKAQEASLIKQ---LESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLT 2138
R ++ +L+++ LE + +++ +L++ L+ +AK ++ SS E + +
Sbjct: 726 RAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLE--SSLFEAQQQNSVI 783
Query: 2139 PLHRSETAKNWKSLTES-ERSRGSLESIAEHVDASLSGSE-----------------RSV 2180
+ + + +++T++ E +G + + +D S +E ++
Sbjct: 784 EVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTA 843
Query: 2181 SERSLSAYAKRVN-----------------------------EWDSRTEDFQTPSPVLRS 2211
E+ +A+ K VN E + R ++ QT +++
Sbjct: 844 LEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA 903
Query: 2212 SRKIREESGDSL----------ENVPALHLL----KELNATSRILDMSDGKVGESSKKSE 2257
R+ +S E V L L KEL S+ L+ ++ + K +
Sbjct: 904 QREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE----RLRQDMKVQK 959
Query: 2258 IKEIEYTKLKKSKIEDA------FSKEGKSDVLLKLVLEQGDSSEILSKKDLPLDSENVQ 2311
+KE E T + ++++++A +++ + D+ L++ SS + K DL E+++
Sbjct: 960 LKEQETTGILQTQLQEAQRELKEAARQHRDDL---AALQEESSSLLQDKMDLQKQVEDLK 1016
Query: 2312 KDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSE-HLFAP 2370
LV +E+ ++ + Q+ N IQ K++ +K + L E L
Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYN---RIQ--KELEREKASLTLSLMEKEQRLLVL 1071
Query: 2371 KEIPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSSTSGATSFG 2430
+E E+S+ ++++ E + E+S+ + L + Q ++K + +
Sbjct: 1072 QEADSIRQQELSALRQDMQ-EAQGEQKELSAQMELLR--QEVKEKEADFLAQEAQLLEEL 1128
Query: 2431 SNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESPSLASVPT 2490
I+E SL + L L+S TE ++ + Q LAS+ +
Sbjct: 1129 EASHITEQQLRASLWAQEAKAAQLQLRLRS-TESQLEALAAEQQPGNQAQAQAQLASLYS 1187
Query: 2491 ADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFEC 2550
A + +G+V G A W G+E D+ NG + F+
Sbjct: 1188 ALQ---------QALGSVCESRPELSGGGDSAPSVW-GLEPDQ-----NGAR---SLFKR 1229
Query: 2551 KEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSE 2610
+ S + + D + D D+ Q + DTE K +
Sbjct: 1230 GPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQ-VQKLEERLTDTEAEKSQVH---- 1284
Query: 2611 YFYEKSLPSVNDIEASVNRSRSLKIETDNVQDI--SGVLEAHVHQQSSVDSQISSKENKD 2668
+ D++ +++++ K + + Q+ S ++E H +S+ S++ E +
Sbjct: 1285 -------TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELH-ETMASLQSRLRRAELQR 1336
Query: 2669 LISDATEKVSIAAEDD---TLDNTFSEELEKQQQFTE----EEDNLYAEASEKLCTPLLD 2721
+ + ++ AA+++ +++ + +E + Q + EED A ++ KL +
Sbjct: 1337 MEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKN---E 1393
Query: 2722 LLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLL--KVFVKDTVNQLQQIKKTRDE 2779
+ E+ + +A + + + K E ++LLT +L + V+ Q+Q+++K R+
Sbjct: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQRE- 1452
Query: 2780 KIQLSNQELLGDDQKKVTPQ-DLSQNVEEQSPSISGC 2815
+Q + ELL D KK + DL Q EQ + C
Sbjct: 1453 -MQKAALELLSLDLKKRNQEVDLQQ---EQIQELEKC 1485
Score = 43.9 bits (102), Expect = 0.002
Identities = 105/519 (20%), Positives = 208/519 (40%), Gaps = 77/519 (14%)
Query: 1858 LTKREQKLMQRRQHAEELLEWKRRLDAEEAEI--RQMEKQALAAWDKELIKP-----KTP 1910
L K ++ + + ++EL++ K + D E+AE+ R E AL ++ + K
Sbjct: 250 LAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKAL 309
Query: 1911 KKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPD 1970
++ +E T E+ E S L + E +++ + + E Q +
Sbjct: 310 RETVEILETNHTELMEHEAS---LSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHE 366
Query: 1971 HSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGG-QCHLPIKSHQHCY 2029
+S+ + I SQ + + +L +S + +Q + G Q + + QH
Sbjct: 367 NSLELDSSIFSQ-FDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQH-D 424
Query: 2030 SWSDESLSMTQ--SETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQE 2087
W +E ++ Q + T ++ + G+ L+ E V+ L KE++ QK R + ++
Sbjct: 425 QWEEEGKALRQRLQKLTGERDTLAGQTVDLQGE-------VDSLSKERELLQKAREELRQ 477
Query: 2088 ASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAK 2147
+ + E++ E +L D + Q + + E+ +++ + AK
Sbjct: 478 QLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEML---MGLEAK 534
Query: 2148 NWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSP 2207
+SL+E R +LES H++ L E++ +L+ + + E S +T
Sbjct: 535 QSESLSELITLREALES--SHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVA 592
Query: 2208 VLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLK 2267
LR++ +L+A + L + KVG + + +++E +
Sbjct: 593 DLRAA-------------------AVKLSALNEALALD--KVGLNQQLLQLEEENQSVC- 630
Query: 2268 KSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGLAIENLHKSEE 2327
S++E A E + L + E E L +K+ L+++ L K+EE
Sbjct: 631 -SRMEAA---EQARNALQVDLAEAEKRREALWEKNTHLEAQ-------------LQKAEE 673
Query: 2328 MLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWSEH 2366
E Q+D +DI E+K +K LS S H
Sbjct: 674 AGAELQADL-----------RDIQEEKEEIQKKLSESRH 701
Score = 39.3 bits (90), Expect = 0.061
Identities = 62/319 (19%), Positives = 131/319 (41%), Gaps = 43/319 (13%)
Query: 2623 IEASVNRSRSLKIETDNVQDISGVL-EAHVHQQSSVDSQISSKENKDLISDATEKVSIAA 2681
+EA+ +L+++ + L E + H ++ + Q + + +L +D + I
Sbjct: 633 MEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQL--QKAEEAGAELQADLRD---IQE 687
Query: 2682 EDDTLDNTFSEELEKQQQFTEEEDNLYAEASEK-----LCTPLLDLLTREKNQLEAQLKS 2736
E + + SE +Q+ T + + L+ EA + + L REK LE +L++
Sbjct: 688 EKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQA 747
Query: 2737 SLNEEKKSKQQLEKIS----LLTDSLLKVFVKDTV---------NQLQQIKKTRDE---- 2779
+ + +QL+ +S LL SL + +++V Q+Q + + ++
Sbjct: 748 VERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGE 807
Query: 2780 ----KIQLSNQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDEKEEISSPDMCP 2835
K++L + + ++ + L+Q +E ++ + EKE +
Sbjct: 808 VRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE----QQKAAHEKEVNQLREKWE 863
Query: 2836 RPESPVFGASGQEELAKRLAELELSREFLSALGDDQDWFDEDFGLSSSHKIQKNKAEETI 2895
+ S Q+ELAK L LE + L +Q E + + + ++ +AE +
Sbjct: 864 KERS-----WHQQELAKALESLEREKMELEMRLKEQQ--TEMEAIQAQREEERTQAESAL 916
Query: 2896 VPLMAEPKRVTQQPCETLL 2914
+ E ++ ETLL
Sbjct: 917 CQMQLETEKERVSLLETLL 935
Score = 33.5 bits (75), Expect = 3.4
Identities = 51/209 (24%), Positives = 88/209 (42%), Gaps = 31/209 (14%)
Query: 2633 LKIETDNVQDISGVLEAHVH-QQSSVDSQISSKENKDLISDATEKVSIAAEDDTLDNTFS 2691
L+++ V V++ V + +D++ S E + DA + AE +
Sbjct: 790 LEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQE---RDAAARQLAQAEQEG-----K 841
Query: 2692 EELEKQQQFTEEEDNLYAEASEKL-------CTPLLDLLTREKNQLEAQLKSSLNEEKKS 2744
LE+Q+ E+E N E EK L+ L REK +LE +LK E +
Sbjct: 842 TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAI 901
Query: 2745 KQQLEKISLLTDSLLKVF----VKDTVNQLQQIKKTRDEKIQLSNQ-ELLGDDQKKVTPQ 2799
+ Q E+ +S L K+ V+ L+ + +T+ E S Q E L D K
Sbjct: 902 QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMK----- 956
Query: 2800 DLSQNVEEQSPSISGCFLSSELEDEKEEI 2828
Q ++EQ + L ++L++ + E+
Sbjct: 957 --VQKLKEQETT---GILQTQLQEAQREL 980
Score = 33.5 bits (75), Expect = 3.4
Identities = 24/106 (22%), Positives = 47/106 (44%), Gaps = 4/106 (3%)
Query: 591 YDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSE 650
+D + + R+ +ER ++ +++ +E QK Q+L R+ +E + + + E
Sbjct: 1612 HDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLE 1671
Query: 651 PSATRRLQETYSKLLLEKTLLEEPSHQHVTQ----ETQAKPGYQPS 692
TR+ + L K L E + TQ + +A+ G PS
Sbjct: 1672 DQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPS 1717
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.124 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 120,268,647
Number of Sequences: 37866
Number of extensions: 5903696
Number of successful extensions: 45377
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 214
Number of HSP's successfully gapped in prelim test: 1471
Number of HSP's that attempted gapping in prelim test: 25926
Number of HSP's gapped (non-prelim): 15095
length of query: 3117
length of database: 18,247,518
effective HSP length: 121
effective length of query: 2996
effective length of database: 13,665,732
effective search space: 40942533072
effective search space used: 40942533072
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.