BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|170784856 serine/threonine kinase 31 isoform b [Homo sapiens] (996 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|170784859 serine/threonine kinase 31 isoform b [Homo sapiens] 1970 0.0 gi|14602443 serine/threonine kinase 31 isoform a [Homo sapiens] 1970 0.0 gi|170784856 serine/threonine kinase 31 isoform b [Homo sapiens] 1970 0.0 gi|38505161 tudor domain containing 1 [Homo sapiens] 57 7e-08 gi|30039692 NIMA-related kinase 8 [Homo sapiens] 57 9e-08 gi|58197558 tudor domain containing 6 [Homo sapiens] 54 6e-07 gi|71061468 centromere protein E [Homo sapiens] 53 1e-06 gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 53 1e-06 gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 53 2e-06 gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 53 2e-06 gi|208431829 eukaryotic translation initiation factor 2-alpha ki... 52 2e-06 gi|208431827 eukaryotic translation initiation factor 2-alpha ki... 52 2e-06 gi|4506103 eukaryotic translation initiation factor 2-alpha kina... 52 2e-06 gi|110349799 testis-specific protein kinase 2 [Homo sapiens] 51 5e-06 gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 51 6e-06 gi|223671888 interleukin-1 receptor-associated kinase 4 isoform ... 49 2e-05 gi|223671885 interleukin-1 receptor-associated kinase 4 isoform ... 49 2e-05 gi|223671883 interleukin-1 receptor-associated kinase 4 isoform ... 49 2e-05 gi|166795293 interleukin-1 receptor-associated kinase 4 isoform ... 49 2e-05 gi|166795295 interleukin-1 receptor-associated kinase 4 isoform ... 49 2e-05 gi|4758650 kinesin family member 5C [Homo sapiens] 49 3e-05 gi|148839316 NIMA-related kinase 4 [Homo sapiens] 49 3e-05 gi|66932999 testis-specific protein kinase 1 [Homo sapiens] 48 5e-05 gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 47 7e-05 gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform... 47 9e-05 gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent ... 47 9e-05 gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo ... 47 9e-05 gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 47 9e-05 gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 47 9e-05 gi|118498362 kinectin 1 isoform b [Homo sapiens] 46 2e-04 >gi|170784859 serine/threonine kinase 31 isoform b [Homo sapiens] Length = 996 Score = 1970 bits (5104), Expect = 0.0 Identities = 996/996 (100%), Positives = 996/996 (100%) Query: 1 MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK 60 MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK Sbjct: 1 MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK 60 Query: 61 IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY 120 IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY Sbjct: 61 IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY 120 Query: 121 KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV 180 KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV Sbjct: 121 KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV 180 Query: 181 LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM 240 LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM Sbjct: 181 LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM 240 Query: 241 TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES 300 TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES Sbjct: 241 TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES 300 Query: 301 YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS 360 YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS Sbjct: 301 YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS 360 Query: 361 VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE 420 VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE Sbjct: 361 VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE 420 Query: 421 MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC 480 MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC Sbjct: 421 MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC 480 Query: 481 DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC 540 DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC Sbjct: 481 DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC 540 Query: 541 KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS 600 KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS Sbjct: 541 KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS 600 Query: 601 PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY 660 PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY Sbjct: 601 PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY 660 Query: 661 HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR 720 HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR Sbjct: 661 HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR 720 Query: 721 PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP 780 PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP Sbjct: 721 PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP 780 Query: 781 MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL 840 MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL Sbjct: 781 MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL 840 Query: 841 NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV 900 NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV Sbjct: 841 NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV 900 Query: 901 QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP 960 QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP Sbjct: 901 QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP 960 Query: 961 EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC 996 EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC Sbjct: 961 EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC 996 >gi|14602443 serine/threonine kinase 31 isoform a [Homo sapiens] Length = 1019 Score = 1970 bits (5104), Expect = 0.0 Identities = 996/996 (100%), Positives = 996/996 (100%) Query: 1 MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK 60 MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK Sbjct: 24 MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK 83 Query: 61 IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY 120 IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY Sbjct: 84 IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY 143 Query: 121 KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV 180 KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV Sbjct: 144 KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV 203 Query: 181 LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM 240 LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM Sbjct: 204 LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM 263 Query: 241 TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES 300 TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES Sbjct: 264 TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES 323 Query: 301 YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS 360 YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS Sbjct: 324 YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS 383 Query: 361 VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE 420 VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE Sbjct: 384 VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE 443 Query: 421 MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC 480 MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC Sbjct: 444 MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC 503 Query: 481 DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC 540 DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC Sbjct: 504 DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC 563 Query: 541 KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS 600 KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS Sbjct: 564 KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS 623 Query: 601 PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY 660 PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY Sbjct: 624 PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY 683 Query: 661 HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR 720 HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR Sbjct: 684 HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR 743 Query: 721 PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP 780 PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP Sbjct: 744 PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP 803 Query: 781 MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL 840 MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL Sbjct: 804 MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL 863 Query: 841 NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV 900 NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV Sbjct: 864 NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV 923 Query: 901 QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP 960 QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP Sbjct: 924 QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP 983 Query: 961 EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC 996 EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC Sbjct: 984 EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC 1019 >gi|170784856 serine/threonine kinase 31 isoform b [Homo sapiens] Length = 996 Score = 1970 bits (5104), Expect = 0.0 Identities = 996/996 (100%), Positives = 996/996 (100%) Query: 1 MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK 60 MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK Sbjct: 1 MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK 60 Query: 61 IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY 120 IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY Sbjct: 61 IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY 120 Query: 121 KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV 180 KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV Sbjct: 121 KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV 180 Query: 181 LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM 240 LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM Sbjct: 181 LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM 240 Query: 241 TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES 300 TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES Sbjct: 241 TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES 300 Query: 301 YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS 360 YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS Sbjct: 301 YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS 360 Query: 361 VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE 420 VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE Sbjct: 361 VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE 420 Query: 421 MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC 480 MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC Sbjct: 421 MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC 480 Query: 481 DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC 540 DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC Sbjct: 481 DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC 540 Query: 541 KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS 600 KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS Sbjct: 541 KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS 600 Query: 601 PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY 660 PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY Sbjct: 601 PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY 660 Query: 661 HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR 720 HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR Sbjct: 661 HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR 720 Query: 721 PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP 780 PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP Sbjct: 721 PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP 780 Query: 781 MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL 840 MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL Sbjct: 781 MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL 840 Query: 841 NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV 900 NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV Sbjct: 841 NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV 900 Query: 901 QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP 960 QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP Sbjct: 901 QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP 960 Query: 961 EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC 996 EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC Sbjct: 961 EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC 996 >gi|38505161 tudor domain containing 1 [Homo sapiens] Length = 1189 Score = 57.4 bits (137), Expect = 7e-08 Identities = 54/179 (30%), Positives = 83/179 (46%), Gaps = 10/179 (5%) Query: 14 VGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDP--NKIYGGLFSEDQC 71 V +HI+ F+ Q + + + ++ SLS+ C Q + P I FSED Sbjct: 499 VVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQLPP-RSDFYPAIGDICCAQFSEDDQ 557 Query: 72 WYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVE-IPLELQFSSVAKKYKLWGLHIPSD 130 WYR VL S E LV Y+DYGN EIL+ + IP L+ A K L G+ PS Sbjct: 558 WYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVK-PSL 616 Query: 131 QEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGT---VIAQAEYGSVDIGEEVLKKGFA 186 T + + L+ K I +++ E+ + +I ++E V + + +L GFA Sbjct: 617 GIWT--PEAICLMKKLVQNKIITVKVVDKLENSSLVELIDKSETPHVSVSKVLLDAGFA 673 Score = 36.2 bits (82), Expect = 0.16 Identities = 32/141 (22%), Positives = 59/141 (41%), Gaps = 17/141 (12%) Query: 8 DKVEDVVGSHIEDAVTFWAQSINRN--KDIMKIGCSLSEVCPQASSVLGNLDPNKIYGGL 65 D+ DVV I F+ + + K + + SL+E C Q + + Sbjct: 713 DQTVDVVVCVIYSPGEFYCHVLKEDALKKLNDLNKSLAEHCQQKLPNGFKAEIGQPCCAF 772 Query: 66 FSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDI-------VEIP---LELQFSS 115 F+ D WYR V +I+ V ++DYGN E + ++ + +P + Q + Sbjct: 773 FAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLAD 832 Query: 116 VAKKYKLWGLHIPSDQEVTQF 136 + + K W S++ +T+F Sbjct: 833 IQSRNKHW-----SEEAITRF 848 Score = 30.4 bits (67), Expect = 8.6 Identities = 14/35 (40%), Positives = 21/35 (60%), Gaps = 1/35 (2%) Query: 66 FSEDQCWYRCKVLKI-ISVEKCLVRYIDYGNTEIL 99 ++ DQ W R + + + +K V YIDYGN EI+ Sbjct: 323 YTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEII 357 >gi|30039692 NIMA-related kinase 8 [Homo sapiens] Length = 692 Score = 57.0 bits (136), Expect = 9e-08 Identities = 36/111 (32%), Positives = 57/111 (51%), Gaps = 3/111 (2%) Query: 798 QANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFALNREQGIV--GDFDFTKS 855 + N L E L + LH +H I+H L N+ L++ + +V GDF +K Sbjct: 95 RCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNIL-LDKHRMVVKIGDFGISKI 153 Query: 856 VSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSVQNQEFE 906 +S ++ +VG +SPEL GKP + SD++A GC+L L+ + FE Sbjct: 154 LSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFE 204 >gi|58197558 tudor domain containing 6 [Homo sapiens] Length = 2096 Score = 54.3 bits (129), Expect = 6e-07 Identities = 65/221 (29%), Positives = 100/221 (45%), Gaps = 40/221 (18%) Query: 5 THYDKV---EDVVGSHIEDAVTFWAQSINRNKDIMK-IGCSLSEVCPQASSVLGNLDPNK 60 TH K+ E V +HI+D TF+ Q + RN +I++ + CS++ Q S VL NL + Sbjct: 979 THDMKIGSEELVYITHIDDPWTFYCQ-LARNANILEQLSCSIT----QLSKVLLNLKTSP 1033 Query: 61 IYGGLFS----EDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIP------LE 110 + G D WYR V I E V ++D+GN ++ D++ IP L Sbjct: 1034 LNPGTLCLAKYTDGNWYRGIV---IEKEPKKVFFVDFGNIYVVTSDDLLPIPSDAYDVLL 1090 Query: 111 LQFSSVAKKYKLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAE 170 L +V HIP +EV + Q T I +K +K + A DGT+I + Sbjct: 1091 LPMQAVRCSLSDIPDHIP--EEVVVWFQET------ILDKSLKALVVAKDPDGTLIIELY 1142 Query: 171 YGSVDIGEEVLKK----GFAEKCR------LASRTDICEEK 201 ++ I + KK + ++ R L S T+ EEK Sbjct: 1143 GDNIQISASINKKLGLLSYKDRIRKKESEVLCSTTETLEEK 1183 Score = 42.0 bits (97), Expect = 0.003 Identities = 26/95 (27%), Positives = 44/95 (46%), Gaps = 1/95 (1%) Query: 16 SHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGN-LDPNKIYGGLFSEDQCWYR 74 SHI D F+ Q I +I + L+ V + +G L + +F ED WYR Sbjct: 1312 SHINDLSDFYVQLIEDEAEISHLSERLNSVKTRPEYYVGPPLQRGDMICAVFPEDNLWYR 1371 Query: 75 CKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPL 109 + + + V++IDYGN +++ + I + L Sbjct: 1372 AVIKEQQPNDLLSVQFIDYGNVSVVHTNKIGRLDL 1406 Score = 33.1 bits (74), Expect = 1.3 Identities = 30/128 (23%), Positives = 54/128 (42%), Gaps = 13/128 (10%) Query: 16 SHIEDAVTFWAQSINRNKDIMKIGCSLSEVC-----PQASSVLGNLDPNKIYGGLFSEDQ 70 S++E+ FW Q + + + + C P + L L + ++ Sbjct: 779 SYVENPGYFWCQLTRNIQGLKTLMSDIQYYCKNTAAPHQRNTLACLAKRTV-------NR 831 Query: 71 CWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLE-LQFSSVAKKYKLWGLHIPS 129 W R + I SVE V ++DYG+ E+++ +I I E L+ + A + L+ L P Sbjct: 832 QWSRALISGIQSVEHVNVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSLYNLIQPV 891 Query: 130 DQEVTQFD 137 Q +D Sbjct: 892 GQNPFVWD 899 >gi|71061468 centromere protein E [Homo sapiens] Length = 2701 Score = 53.1 bits (126), Expect = 1e-06 Identities = 89/447 (19%), Positives = 197/447 (44%), Gaps = 40/447 (8%) Query: 243 DLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKT---EKDALLE 299 ++ + + N + E D + + +E+++ ++K E E++K+ E+D L Sbjct: 1297 EVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKT 1356 Query: 300 SYKALELKVEQIAQELQQEKAAAVDLTNHLEYTLK-TYIDTRMKNLAAKMEILKEMRHVD 358 +ALE+K +Q+ + +++ A + + E +L D + ++ME K Sbjct: 1357 IKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSAL 1416 Query: 359 ISVRFGK-DLSDAIQVLDEGCFTTPASLNGL----EIIWAEYSLAQENIK--------TC 405 + + LS +Q + + + L E++ +E +ENIK T Sbjct: 1417 LRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETE 1476 Query: 406 EYVSEGNILIAQRNEMQQKLYMSVEDFILEVDESSLNKRLKTLQD-LSVSLEAVYGQAKE 464 E + + + ++ E +L +++ + E + S++ K+L+ + D L ++ +Y + +E Sbjct: 1477 EELKVAHCCLKEQEETINELRVNLSE--KETEISTIQKQLEAINDKLQNKIQEIY-EKEE 1533 Query: 465 GANSDEILKKFYDWKCDKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDA 524 N +I + K ++ ++F R D++L + + K+ +L+ +++ Sbjct: 1534 QFNIKQISE--VQEKVNELKQFKEHRKAKDSALQSIES------KMLELTNR----LQES 1581 Query: 525 MDNIDEILEKTESSVCKELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYK 584 + I ++++ E K ++ AL + D KE NT V + S+E+ ++ Sbjct: 1582 QEEIQIMIKEKEE--MKRVQEALQIERDQLKE---NTKEIVAKMKESQEKEYQFLKMTAV 1636 Query: 585 DSIEFKKQLIEYLNKSPSVD--HLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIE 642 + + K IE+L + +L +I+ L +L L E ++ + D S E Sbjct: 1637 NETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEE 1696 Query: 643 KIKEEITQLRNNVFQEIYHEREEYEML 669 +K E QL+ N+ + I + E+ E L Sbjct: 1697 TLKVERDQLKENLRETITRDLEKQEEL 1723 Score = 41.6 bits (96), Expect = 0.004 Identities = 88/444 (19%), Positives = 174/444 (39%), Gaps = 57/444 (12%) Query: 272 VSLEKIKQDQKLIEENEKLKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTNHLEY 331 V+L+ ++ L EN +LK + L +YK +E ++ +L+ +K VDL L+ Sbjct: 633 VALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQS 692 Query: 332 T------LKTYIDTRM-KNLAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPAS 384 L + ID ++ K+L +E+ E + D+ K++ + + +E + Sbjct: 693 AFNEITKLTSLIDGKVPKDLLCNLEL--EGKITDLQKELNKEVEENEALREEVILLSELK 750 Query: 385 LNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVDE------ 438 E+ + ++ + SE + L ++ + ++ +E+ D+ Sbjct: 751 SLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQS 810 Query: 439 --SSLNKRLKTLQDLSVSLEAVY---------------GQAKEGANSDE---ILKKFYDW 478 S ++ + + L + E Y +KE D LK + Sbjct: 811 NYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSY 870 Query: 479 KCDKREEFTSVRSETDASLHRLVAWFQ-RTLKVFDLSVEGSLISEDAMDNIDEILEKT-E 536 K + +E T E + +L + R + + E +LI+E ++E+ T E Sbjct: 871 KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQE 930 Query: 537 SSVCKELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEY 596 K+L+ +L + D Q+ IH + Q + ++++E KQ E Sbjct: 931 KDDLKQLQESLQIERD-----------QLKSDIHDTVNMNIDTQEQLRNALESLKQHQET 979 Query: 597 LNK-----SPSVDHLLSIKKTLKSLKALLRWKLV---EKSNLEESDDPDGSQIEKIKEEI 648 +N S V L +++ K + K+V +K +LE + + K E I Sbjct: 980 INTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII 1039 Query: 649 TQLRNNVFQEIYHEREEYEMLTSL 672 Q R +F I + E +ML S+ Sbjct: 1040 EQQR-KIFSLIQEKNELQQMLESV 1062 Score = 37.7 bits (86), Expect = 0.054 Identities = 124/587 (21%), Positives = 236/587 (40%), Gaps = 89/587 (15%) Query: 223 RSNQSTFSRPKGHLSEKMTLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEK-IKQDQ 281 + Q T + +G +SEK + D N +E + N ++L+K + + Q Sbjct: 1784 KEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQ 1843 Query: 282 KLIEENEKLKTE-KDALLESYKALELKVEQIAQELQQ--EKAAAV----DLTNHLEYTLK 334 K + E E+LK + KD L K LE++ +AQ+L + E+ +V D +E TLK Sbjct: 1844 KKVSEMEQLKKQIKDQSLTLSK-LEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLK 1902 Query: 335 TYIDTRMKNL----AAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGL-- 388 D ++L A +EI +E++ + K+ + + L E ++ + Sbjct: 1903 LERDQLKESLQETKARDLEIQQELKTARM---LSKEHKETVDKLREKISEKTIQISDIQK 1959 Query: 389 -------EIIWAEYSLAQENIKTCEYVSEGNILIAQRNEMQQ-KLYMSVEDFILE---VD 437 E+ L ++ ++ + N+ + NEM+Q K ++ ++ +D Sbjct: 1960 DLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMD 2019 Query: 438 ESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKCDKREEFTSVRS--ETDA 495 L K+L SLE + AKE DE+ + K ++ + ++R D Sbjct: 2020 NFQLTKKLHE------SLEEIRIVAKE---RDELRRIKESLKMERDQFIATLREMIARDR 2070 Query: 496 SLH------RLVAWFQRTLKVFDLSVEGSLISE-----DAMDNIDEILEKTESSVCKELE 544 H RL++ Q+ L L + S I E MD+ E L + + KE+E Sbjct: 2071 QNHQVKPEKRLLSDGQQHL-TESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIE 2129 Query: 545 IALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQA--KYKDSIEFKKQLIEYLNKSPS 602 Q + + +N LQ H E+ A + ++ ++ K ++ Y+ K Sbjct: 2130 F----QKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185 Query: 603 VDHLLSIKKTLKSLKALLRWK--LVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY 660 H K + + + + K L++ +L++ D E+ L+ N +++ Sbjct: 2186 EQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVP-------SRELRDLKLNQNMDLH 2238 Query: 661 HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDL---LDAEPMKELS 717 E E+L ++ FP + ++ +++ +T LE L D E +K Sbjct: 2239 IE----EILKDFSESEFPSIKTEFQQV-----LSNRKEMTQFLEEWLNTRFDIEKLKNGI 2289 Query: 718 SKRP----LVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWRE 760 K V + N +II + S + + ER+AT + W + Sbjct: 2290 QKENDRICQVNNFFNNRIIAIMNESTEFE------ERSATISKEWEQ 2330 Score = 31.2 bits (69), Expect = 5.1 Identities = 78/392 (19%), Positives = 164/392 (41%), Gaps = 61/392 (15%) Query: 281 QKLIEENEKLKTEK----DALLESYKALELKVEQIAQE---LQQEKAAAVDLTNHLEYTL 333 + +I E E+LKT+ + +E+ + L L +++ ++ + QEK A+ L T Sbjct: 1060 ESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTC 1119 Query: 334 KTYIDTRMKNLAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWA 393 + K L K + L+E + ++V+ +++S+ + ++E + L+ Sbjct: 1120 DRLAEVEEK-LKEKSQQLQEKQQQLLNVQ--EEMSEMQKKINE--------IENLKNELK 1168 Query: 394 EYSLAQENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVDESSLNKRLKTLQDLSV 453 L E+++T +R E+ QKL + E+ S+ K K L++L Sbjct: 1169 NKELTLEHMET------------ERLELAQKLNENYEEV------KSITKERKVLKELQK 1210 Query: 454 SLEA----VYGQAKE----GANSDEILKKFYDWKCDKREEFTSVRSETDASLHRLVAWFQ 505 S E + G +E G + E LK + + +E +R +++ Sbjct: 1211 SFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQD 1270 Query: 506 RTLKVFDLSVEGSLISE--DAMDNIDEILEKTESSVCKELEIALVDQGDADKEIISNTYS 563 L E ++ E + + N+ E+ E E+ ELE+ D ++ Sbjct: 1271 LEKSHTKLQEEIPVLHEEQELLPNVKEVSETQET--MNELELLTEQSTTKDSTTLARIEM 1328 Query: 564 QVL---QKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKSPSVDHLLSIKKTLKSLKALL 620 + L +K + I ++ K +D+++ K+ +E + +H I++TL ++ Sbjct: 1329 ERLRLNEKFQESQEEIKSL-TKERDNLKTIKEALE-VKHDQLKEH---IRETLAKIQE-S 1382 Query: 621 RWKLVEKSNLEESDDPDGSQIEKIKEEITQLR 652 + K + N++E D ++ KI E+ Q + Sbjct: 1383 QSKQEQSLNMKEKD----NETTKIVSEMEQFK 1410 >gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo sapiens] Length = 966 Score = 53.1 bits (126), Expect = 1e-06 Identities = 32/129 (24%), Positives = 62/129 (48%), Gaps = 2/129 (1%) Query: 770 LIFLFLCKSDPMAYLMVPYYPRANLNAV-QANMPLNSEETLKVMKGVAQGLHTLHKADII 828 + F +C P +++ Y L V +A + + G+A G++ LH II Sbjct: 217 IAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKII 276 Query: 829 HGSLHQNNVFALNREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDL 888 H L NV + + + DF +K +S +++ G ++ M+PE+ +P S D+ Sbjct: 277 HRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDI 336 Query: 889 YAYGCLLLW 897 +++G ++LW Sbjct: 337 WSFG-VVLW 344 >gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo sapiens] Length = 1938 Score = 52.8 bits (125), Expect = 2e-06 Identities = 124/564 (21%), Positives = 226/564 (40%), Gaps = 95/564 (16%) Query: 236 LSEKMTLDLKDENDAGNLITFPKESLAVGDFN----LGSNVSLE-KIKQDQKLIEENEKL 290 L EKM L+++ND + E+L + + S + LE K+K+ + +EE E++ Sbjct: 877 LEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEM 936 Query: 291 KTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEI 350 +E L+ + LE K + +++ ++LT K + ++KNL+ +M Sbjct: 937 NSE---LVAKKRNLEDKCSSLKRDIDD-----LELTLTKVEKEKHATENKVKNLSEEMTA 988 Query: 351 LKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSE 410 L+E ++ + K L +A Q + +NGL I A+ +++ E Sbjct: 989 LEE--NISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDL-------E 1039 Query: 411 GNILIAQRNEMQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDE 470 G++ E ++KL +E + K DL +S E++ + +E Sbjct: 1040 GSL------EQEKKLRADLE-----------RAKRKLEGDLKMSQESIMDLENDKQQIEE 1082 Query: 471 ILKKFYDWKCDKREEFTSVRSETD-ASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNID 529 LKK K E + ++++ D +H L FQ+ +K +E +A + Sbjct: 1083 KLKK-------KEFELSQLQAKIDDEQVHSLQ--FQKKIKELQARIEELEEEIEAEHTLR 1133 Query: 530 EILEKTESSVCKELEIALVDQGDADKEIISNTYSQVLQKIHSEERLI--------ATVQA 581 +EK S + +ELE + + +E T +Q+ E AT+Q Sbjct: 1134 AKIEKQRSDLARELE----EISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQH 1189 Query: 582 KYKDSIEFKKQLIEYLNKSPSVDHLLSIKKTLKSLKALLRWKLVE-----------KSNL 630 + + KKQ +D+L +K+ L+ K+ L+ ++ + KSN+ Sbjct: 1190 EATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNI 1249 Query: 631 EESDDPDGSQIEKIK---EEITQLRNNVFQ----------EIYHEREEYEMLTSLAQK-- 675 E + Q +IK E+ TQL +++ E+ H EE E L S K Sbjct: 1250 ERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSK 1309 Query: 676 -----WFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKRPLVR--SEVN 728 EL E K + L + + DLL + +E +K L R S+ N Sbjct: 1310 QALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKAN 1369 Query: 729 GQIILLK-GYSVDVDTEAKVIERA 751 ++ + Y D + +E A Sbjct: 1370 SEVAQWRTKYETDAIQRTEELEEA 1393 Score = 36.6 bits (83), Expect = 0.12 Identities = 78/382 (20%), Positives = 154/382 (40%), Gaps = 41/382 (10%) Query: 284 IEENEKLKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKN 343 +EE E L ++ L +S +AL ++E++ +++++E A + + L+ + + D + Sbjct: 1295 VEEKESLISQ---LTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSS-RHDCDLLREQ 1350 Query: 344 LAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIK 403 + E E++ K S+ Q + + T A E+ A+ LAQ + Sbjct: 1351 YEEEQEAKAELQRA-----LSKANSEVAQWRTK--YETDAIQRTEELEEAKKKLAQRLQE 1403 Query: 404 TCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAK 463 E N A + +Q+L VED ++DL S A K Sbjct: 1404 AEENTETANSKCASLEKTKQRLQGEVEDL---------------MRDLERSHTACATLDK 1448 Query: 464 EGANSDEILKKFYDWKCDKREEFTSVRSETDASLHRLVAWFQRTLKVFD----LSVEGSL 519 + N D++L ++ + + E + + E+ + L +V D L E Sbjct: 1449 KQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKN 1508 Query: 520 ISEDAMDNIDEILEKTESSVCKELEIALVDQGDADKEIISNTYSQVLQKIHSEERL---- 575 + E+ D ++I E ++ E LV+Q +D ++ L+ H E ++ Sbjct: 1509 LQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLE--HEESKILRVQ 1566 Query: 576 --IATVQAKYKDSIEFKKQLIEYL--NKSPSVDHLLSI-KKTLKSLKALLRWKLVEKSNL 630 ++ V+++ + K + IE L N + + L S+ ++S LR K + +L Sbjct: 1567 LELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDL 1626 Query: 631 EESDDPDGSQIEKIKEEITQLR 652 E + G ++ E LR Sbjct: 1627 NEMEIQLGHSNRQMAETQKHLR 1648 >gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] Length = 1411 Score = 52.8 bits (125), Expect = 2e-06 Identities = 101/456 (22%), Positives = 190/456 (41%), Gaps = 80/456 (17%) Query: 281 QKLIEENEKLKTEKDALLESYKALELKVEQIAQEL-----------QQEKAAAVDLTNHL 329 Q + E +K+K EK+AL+ ++ K+ +++ L Q+ KAA +DL Sbjct: 835 QTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTC 894 Query: 330 EYTLKTYIDTRMKNLAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGL- 388 + LK + +M+N LKE + + S+ K+ S +++ LN + Sbjct: 895 K-ELKHQLQVQMEN------TLKEQKELKKSLEKEKEASHQLKL----------ELNSMQ 937 Query: 389 -EIIWAEYSLAQENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVD-------ESS 440 ++I A+ +L Q + E +GNI +++ Q+K + L++ E+ Sbjct: 938 EQLIQAQNTLKQNEKE--EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK 995 Query: 441 LNKRL-KTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKCDKREEFTSVRSETDASLHR 499 L ++L + Q+L+ E + S E K+ + E + R + + + Sbjct: 996 LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055 Query: 500 LVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVCKELEI--ALVDQGDADKEI 557 L SL ED + N ++I ++ + +EL+ A ++Q A KE Sbjct: 1056 L-----------------SLAQEDLISNRNQI--GNQNKLIQELKTAKATLEQDSAKKEQ 1096 Query: 558 ISNTYSQVLQKIHSE----ERLIATVQAKYKDSIEFK---KQLIEYLNKSPSVDHLLSIK 610 + LQ I E E+ + ++K + E K ++ I LN+ L SIK Sbjct: 1097 QLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK 1156 Query: 611 K--TLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIYHEREEYEM 668 + LK K LL + +K L+ D + +E+ K L++ V ++EE E+ Sbjct: 1157 EITNLKDAKQLL---IQQKLELQGKADSLKAAVEQEKRNQQILKDQV------KKEEEEL 1207 Query: 669 LTSLAQKWFP-ELPLLHPEIGLLKYMNSGGLLTMSL 703 +K + E+G+ K+ + LTM + Sbjct: 1208 KKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQI 1243 Score = 43.9 bits (102), Expect = 8e-04 Identities = 88/439 (20%), Positives = 166/439 (37%), Gaps = 89/439 (20%) Query: 268 LGSNVSLEKIKQDQKLIEENEKLKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTN 327 L N++LE+ + E+EKLK E L Y + E + Q+ EL + Sbjct: 236 LMDNMTLERER-------ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQ 288 Query: 328 HLEYTLKTYIDTRMKNLAAKMEILK--------EMRHVDISVR--------FGKDLSDAI 371 L+ + + KN +LK E +H + SV KDL Sbjct: 289 ELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLD--C 346 Query: 372 QVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSE--------------------- 410 Q L + SL+ + + +E A + +K E +SE Sbjct: 347 QQLQSRLSASETSLHRIHVELSEKGEATQKLK--EELSEVETKYQHLKAEFKQLQQQREE 404 Query: 411 ----GNILIAQRNEMQQKLYMSVEDF---------ILEVDESSLNKRLKTLQDLSVSLEA 457 G L ++ N++ KL + ++ L + + + DL + L Sbjct: 405 KEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSR 464 Query: 458 VYGQAKEGANSDEILKKFYDWKCDKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEG 517 + Q KE + L+ D + +E +++ T A L ++ L+ Sbjct: 465 LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIG----- 519 Query: 518 SLISEDAMDNIDEILEKTESSVC---KELE--IALVDQGDADKEIISNTYSQVLQKIHSE 572 + + N++ +L+K++ ++ KE E A + G+ + ++ +Q+ +K H+ Sbjct: 520 --DKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL----NQLQEKNHTL 573 Query: 573 ERLIATVQAKYKDSIEFKKQLIEYLNKSPSVDHLLSIKKTLKSLKALLRWKLVEKSNLEE 632 + + + K K+ E KQ E L+ ++ KA LR +LE Sbjct: 574 QEQVTQLTEKLKNQSESHKQAQENLHDQ------------VQEQKAHLRAAQDRVLSLET 621 Query: 633 SDDPDGSQIEKIKEEITQL 651 S + SQ+ + KE+++QL Sbjct: 622 SVNELNSQLNESKEKVSQL 640 Score = 41.2 bits (95), Expect = 0.005 Identities = 106/529 (20%), Positives = 220/529 (41%), Gaps = 72/529 (13%) Query: 283 LIEENEKLKTEKDALLESYKALELKVEQIAQELQQEK-------AAAVDLTNHLEYTLKT 335 L ++ E+L+ + L ++ EQ Q+LQQ++ A +L+ LE + Sbjct: 721 LEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI 780 Query: 336 YIDTRMKNLAAKMEILKEMRHVDISVRFGKD-LSDAIQVLDEGCFTTPASLNGLEIIWAE 394 TR+ +L K E L+ ++ K L + L + LN I Sbjct: 781 VSSTRL-DLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN-RIQTTV 838 Query: 395 YSLAQENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVDES-----SLNKRLKTLQ 449 L + ++ ++E + + + +++ L S +F E + L K K L+ Sbjct: 839 TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK 898 Query: 450 -DLSVSLEAVYGQAKEGANSDEILKKFYDWKCDKREEFTSVRSETDASLHRLVAWFQRTL 508 L V +E + KE LKK + ++E ++ E ++ +L+ Q TL Sbjct: 899 HQLQVQMENTLKEQKE-------LKKSLE---KEKEASHQLKLELNSMQEQLIQ-AQNTL 947 Query: 509 KVFDLSVEGSLISEDAMDNIDEILEKTE------SSVCKELEIALVDQGDADKEIISNTY 562 K + + NI+E+ + +E ++ EL+IA++ + + + + + Sbjct: 948 K------QNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK-LQQQL 1000 Query: 563 SQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKSPSVDHLLSIKKTLKSLKALL-- 620 +Q Q++ +E+ I+ +Q Y+ S E KQL S LL+ ++ LKS++ L Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRES--ELLATRQDLKSVEEKLSL 1058 Query: 621 --------------RWKLVE-----KSNLEESDDPDGSQIE---KIKEEITQLRNNVFQE 658 + KL++ K+ LE+ Q++ K ++I + ++ +E Sbjct: 1059 AQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKE 1118 Query: 659 IYHEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSS 718 + +E+ + + + + E+ L+ E+ K + + + + LL + + EL Sbjct: 1119 LVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKL-ELQG 1177 Query: 719 KRPLVRSEV-----NGQIILLKGYSVDVDTEAKVIERAATYHRAWREAE 762 K +++ V N QI+ + + + + + IE+ A H +E E Sbjct: 1178 KADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKE 1226 >gi|208431829 eukaryotic translation initiation factor 2-alpha kinase 2 isoform b [Homo sapiens] Length = 510 Score = 52.4 bits (124), Expect = 2e-06 Identities = 49/166 (29%), Positives = 73/166 (43%), Gaps = 14/166 (8%) Query: 809 LKVMKGVAQGLHTLHKADIIHGSLHQNNVFALNREQGIVGDFDFTKSVSQRASVNMMVGD 868 L++ + + +G+ +H +IH L +N+F ++ +Q +GDF S+ G Sbjct: 351 LELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGT 410 Query: 869 LSLMSPELKMGKPASPGSDLYAYGCLLL-WLSVQNQEFEINK------DGIPKVDQFHLD 921 L MSPE + DLYA G +L L V + FE +K DGI D F D Sbjct: 411 LRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIIS-DIF--D 467 Query: 922 DKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNPEKDTEYT 967 K K+LL L+ S E N L +PEK+ +T Sbjct: 468 KKEKTLLQKLL----SKKPEDRPNTSEILRTLTVWKKSPEKNERHT 509 >gi|208431827 eukaryotic translation initiation factor 2-alpha kinase 2 isoform a [Homo sapiens] Length = 551 Score = 52.4 bits (124), Expect = 2e-06 Identities = 49/166 (29%), Positives = 73/166 (43%), Gaps = 14/166 (8%) Query: 809 LKVMKGVAQGLHTLHKADIIHGSLHQNNVFALNREQGIVGDFDFTKSVSQRASVNMMVGD 868 L++ + + +G+ +H +IH L +N+F ++ +Q +GDF S+ G Sbjct: 392 LELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGT 451 Query: 869 LSLMSPELKMGKPASPGSDLYAYGCLLL-WLSVQNQEFEINK------DGIPKVDQFHLD 921 L MSPE + DLYA G +L L V + FE +K DGI D F D Sbjct: 452 LRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIIS-DIF--D 508 Query: 922 DKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNPEKDTEYT 967 K K+LL L+ S E N L +PEK+ +T Sbjct: 509 KKEKTLLQKLL----SKKPEDRPNTSEILRTLTVWKKSPEKNERHT 550 >gi|4506103 eukaryotic translation initiation factor 2-alpha kinase 2 isoform a [Homo sapiens] Length = 551 Score = 52.4 bits (124), Expect = 2e-06 Identities = 49/166 (29%), Positives = 73/166 (43%), Gaps = 14/166 (8%) Query: 809 LKVMKGVAQGLHTLHKADIIHGSLHQNNVFALNREQGIVGDFDFTKSVSQRASVNMMVGD 868 L++ + + +G+ +H +IH L +N+F ++ +Q +GDF S+ G Sbjct: 392 LELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGT 451 Query: 869 LSLMSPELKMGKPASPGSDLYAYGCLLL-WLSVQNQEFEINK------DGIPKVDQFHLD 921 L MSPE + DLYA G +L L V + FE +K DGI D F D Sbjct: 452 LRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIIS-DIF--D 508 Query: 922 DKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNPEKDTEYT 967 K K+LL L+ S E N L +PEK+ +T Sbjct: 509 KKEKTLLQKLL----SKKPEDRPNTSEILRTLTVWKKSPEKNERHT 550 >gi|110349799 testis-specific protein kinase 2 [Homo sapiens] Length = 571 Score = 51.2 bits (121), Expect = 5e-06 Identities = 49/206 (23%), Positives = 88/206 (42%), Gaps = 18/206 (8%) Query: 723 VRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDPMA 782 VR +GQ++ LK ++ A +++ +R S L F+ +C Sbjct: 75 VRHRASGQVMALKMNTLS-SNRANMLKEVQLMNRL-------SHPNILRFMGVCVHQGQL 126 Query: 783 YLMVPYYPRANLNAV-QANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFALN 841 + + Y NL + +N+ L +K+ +A GL LH I H L N Sbjct: 127 HALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKR 186 Query: 842 REQG---IVGDFDFTKS---VSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLL 895 E G +V DF + VS + +VG M+PE+ +P + +D+++YG +L Sbjct: 187 DENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIIL 246 Query: 896 LWLSVQNQEFEINKDGIPKVDQFHLD 921 + + + + D +P+ + F LD Sbjct: 247 CEIIAR---IQADPDYLPRTENFGLD 269 >gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo sapiens] Length = 859 Score = 50.8 bits (120), Expect = 6e-06 Identities = 31/129 (24%), Positives = 63/129 (48%), Gaps = 2/129 (1%) Query: 770 LIFLFLCKSDPMAYLMVPYYPRANLNAV-QANMPLNSEETLKVMKGVAQGLHTLHKADII 828 + F +C P +++ + + L V +A P+ + G+A G++ LH II Sbjct: 174 ITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKII 233 Query: 829 HGSLHQNNVFALNREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDL 888 H L N+ + + DF +K +S +++ G ++ M+PE+ +P S D+ Sbjct: 234 HRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDI 293 Query: 889 YAYGCLLLW 897 +++G ++LW Sbjct: 294 WSFG-VVLW 301 >gi|223671888 interleukin-1 receptor-associated kinase 4 isoform b [Homo sapiens] Length = 336 Score = 48.9 bits (115), Expect = 2e-05 Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 18/141 (12%) Query: 784 LMVPYYPRANL----NAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFA 839 L+ Y P +L + + PL+ K+ +G A G++ LH+ IH + N+ Sbjct: 136 LVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL 195 Query: 840 LNREQGIVGDFDFTKS---VSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLL 896 + DF ++ +Q + +VG + M+PE G+ +P SD+Y++G +LL Sbjct: 196 DEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSFGVVLL 254 Query: 897 WLSVQNQEFEINKDGIPKVDQ 917 + G+P VD+ Sbjct: 255 EIIT----------GLPAVDE 265 >gi|223671885 interleukin-1 receptor-associated kinase 4 isoform b [Homo sapiens] Length = 336 Score = 48.9 bits (115), Expect = 2e-05 Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 18/141 (12%) Query: 784 LMVPYYPRANL----NAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFA 839 L+ Y P +L + + PL+ K+ +G A G++ LH+ IH + N+ Sbjct: 136 LVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL 195 Query: 840 LNREQGIVGDFDFTKS---VSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLL 896 + DF ++ +Q + +VG + M+PE G+ +P SD+Y++G +LL Sbjct: 196 DEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSFGVVLL 254 Query: 897 WLSVQNQEFEINKDGIPKVDQ 917 + G+P VD+ Sbjct: 255 EIIT----------GLPAVDE 265 >gi|223671883 interleukin-1 receptor-associated kinase 4 isoform b [Homo sapiens] Length = 336 Score = 48.9 bits (115), Expect = 2e-05 Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 18/141 (12%) Query: 784 LMVPYYPRANL----NAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFA 839 L+ Y P +L + + PL+ K+ +G A G++ LH+ IH + N+ Sbjct: 136 LVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL 195 Query: 840 LNREQGIVGDFDFTKS---VSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLL 896 + DF ++ +Q + +VG + M+PE G+ +P SD+Y++G +LL Sbjct: 196 DEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSFGVVLL 254 Query: 897 WLSVQNQEFEINKDGIPKVDQ 917 + G+P VD+ Sbjct: 255 EIIT----------GLPAVDE 265 >gi|166795293 interleukin-1 receptor-associated kinase 4 isoform a [Homo sapiens] Length = 460 Score = 48.9 bits (115), Expect = 2e-05 Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 18/141 (12%) Query: 784 LMVPYYPRANL----NAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFA 839 L+ Y P +L + + PL+ K+ +G A G++ LH+ IH + N+ Sbjct: 260 LVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL 319 Query: 840 LNREQGIVGDFDFTKS---VSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLL 896 + DF ++ +Q + +VG + M+PE G+ +P SD+Y++G +LL Sbjct: 320 DEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSFGVVLL 378 Query: 897 WLSVQNQEFEINKDGIPKVDQ 917 + G+P VD+ Sbjct: 379 EIIT----------GLPAVDE 389 >gi|166795295 interleukin-1 receptor-associated kinase 4 isoform a [Homo sapiens] Length = 460 Score = 48.9 bits (115), Expect = 2e-05 Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 18/141 (12%) Query: 784 LMVPYYPRANL----NAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFA 839 L+ Y P +L + + PL+ K+ +G A G++ LH+ IH + N+ Sbjct: 260 LVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL 319 Query: 840 LNREQGIVGDFDFTKS---VSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLL 896 + DF ++ +Q + +VG + M+PE G+ +P SD+Y++G +LL Sbjct: 320 DEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSFGVVLL 378 Query: 897 WLSVQNQEFEINKDGIPKVDQ 917 + G+P VD+ Sbjct: 379 EIIT----------GLPAVDE 389 >gi|4758650 kinesin family member 5C [Homo sapiens] Length = 957 Score = 48.5 bits (114), Expect = 3e-05 Identities = 100/483 (20%), Positives = 198/483 (40%), Gaps = 61/483 (12%) Query: 242 LDLKDE--NDAGNLITFPKESLAVGDFNLGSNV-SLEKIKQDQKLIE-ENEKLKTEKDAL 297 LD KD+ N L K+ + D L S EKI+++ ++ ENE K E + Sbjct: 428 LDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEV 487 Query: 298 LESYKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEIL--KEMR 355 L++ + L + +Q +QE++ + A LT+ L T + T + L+ E+ ++ R Sbjct: 488 LQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTT-LTTTQRELSQLQELSNHQKKR 546 Query: 356 HVDISVRFGKDLSDAIQVLDEGCFTTPASLNGL---EIIWAEYSLAQENIKTCEYVSEGN 412 +I KDL + ++ T A +NG+ E A +++ + V+ Sbjct: 547 ATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSK 606 Query: 413 ILIAQRNEMQQKLYMSVEDF-ILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGAN--SD 469 L + + + +K+ S + ++ S ++K+L D ++E Q +E + S+ Sbjct: 607 QLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSE 666 Query: 470 EILK----------KFYD--------------WKCDKREEFTSVRSETDASLHRLVAWFQ 505 E+ K F D K ++ S R L RL + Sbjct: 667 ELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQLSRLRDEIE 726 Query: 506 RTLKVF----DLSVEGSLISEDAMDNIDEI-LEKTESSVCKELEIALVD---QGDADKEI 557 K+ DL+ + L E + +++ +E E + E + L D Q D + Sbjct: 727 EKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLLNDKREQAREDLKG 786 Query: 558 ISNTYSQVLQKIHSEERL-IATVQAKYKDSIEF----------KKQLIEYLNKSPSVDHL 606 + T S+ LQ +H+ +L + + + K S+E +KQ I +L +++ L Sbjct: 787 LEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLEN--NLEQL 844 Query: 607 LSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIYHEREEY 666 + K L A LR +L LE+ +++ ++ + + + N ++ ++E Sbjct: 845 TKVHKQLVRDNADLRCEL---PKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEV 901 Query: 667 EML 669 + + Sbjct: 902 DRI 904 >gi|148839316 NIMA-related kinase 4 [Homo sapiens] Length = 841 Score = 48.5 bits (114), Expect = 3e-05 Identities = 40/154 (25%), Positives = 61/154 (39%), Gaps = 15/154 (9%) Query: 753 TYHRAWREAEGDSGLLPLIFLFLCKSDPMAYLMVPYYPRANLNAVQANMPLNSEETLKVM 812 TY +W EG GLL ++ F D L Q L + ++ Sbjct: 67 TYKESW---EGGDGLLYIVMGFCEGGDLYRKLKE-----------QKGQLLPENQVVEWF 112 Query: 813 KGVAQGLHTLHKADIIHGSLHQNNVFALNREQGIVGDFDFTKSVSQRASV-NMMVGDLSL 871 +A L LH+ I+H L NVF VGD + + + + ++G Sbjct: 113 VQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYY 172 Query: 872 MSPELKMGKPASPGSDLYAYGCLLLWLSVQNQEF 905 MSPEL KP + SD++A GC + ++ F Sbjct: 173 MSPELFSNKPYNYKSDVWALGCCVYEMATLKHAF 206 >gi|66932999 testis-specific protein kinase 1 [Homo sapiens] Length = 626 Score = 47.8 bits (112), Expect = 5e-05 Identities = 38/161 (23%), Positives = 69/161 (42%), Gaps = 12/161 (7%) Query: 770 LIFLFLCKSDPMAYLMVPYYPRANLNAVQANM-PLNSEETLKVMKGVAQGLHTLHKADII 828 L F+ +C + + Y L + ++ PL+ L + +A+GL LH + Sbjct: 113 LRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVF 172 Query: 829 HGSLHQNNVFALNREQG---IVGDFDFTKSV-----SQRASVNMMVGDLSLMSPELKMGK 880 H L N ++G +VGDF + + R +VG M+PE+ G+ Sbjct: 173 HRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGE 232 Query: 881 PASPGSDLYAYGCLLLWLSVQNQEFEINKDGIPKVDQFHLD 921 +D++A+G +L L + + D +P+ + F LD Sbjct: 233 LYDEKADVFAFGIVLCELIAR---VPADPDYLPRTEDFGLD 270 >gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] Length = 1976 Score = 47.4 bits (111), Expect = 7e-05 Identities = 91/427 (21%), Positives = 182/427 (42%), Gaps = 50/427 (11%) Query: 278 KQDQKLIEENEKLKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYI 337 KQ + L EE E LKTE + L++ A + + QE+ + K A + T + E ++ Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQ--- 1195 Query: 338 DTRMKNLAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSL 397 D R ++ A E+ +++ + RF +L Q L+ + L+ + AE Sbjct: 1196 DMRQRHATALEELSEQLEQ---AKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEH 1252 Query: 398 AQENI-----KTCEYVSEGNILIAQRNEMQQKLYMSVEDF--ILE----------VDESS 440 ++ + + VSEG+ L + E KL +++ +LE D +S Sbjct: 1253 KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAAS 1312 Query: 441 LNKRLKTLQDL-------SVSLEAVYGQAKEGANS--------DEILKKFYDWKCDKREE 485 L +L+ Q+L ++L + Q +E NS +E K + + Sbjct: 1313 LESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQ 1372 Query: 486 FTSVRSETDASLHRLVAWFQRTLKVF-DLSVEGSLISEDAMDNIDEILEKTESSVCKELE 544 + + D L + + + K+ D + E A+ + LEKT++ + +EL+ Sbjct: 1373 LADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKAL--AYDKLEKTKNRLQQELD 1430 Query: 545 IALVDQGDADKEIISN--TYSQVLQKIHSEERLIATVQAKYKD--SIEFKKQLIEYLNKS 600 VD D +++ SN + ++ +EE+ I+ A+ +D E +++ + L+ + Sbjct: 1431 DLTVDL-DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLA 1489 Query: 601 PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY 660 +++ L K+ + LR + +L S D G + ++++ L V +E+ Sbjct: 1490 RALEEALEAKEEFERQNKQLR---ADMEDLMSSKDDVGKNVHELEKSKRALEQQV-EEMR 1545 Query: 661 HEREEYE 667 + EE E Sbjct: 1546 TQLEELE 1552 Score = 45.4 bits (106), Expect = 3e-04 Identities = 89/420 (21%), Positives = 179/420 (42%), Gaps = 57/420 (13%) Query: 272 VSLEKIKQDQKLIEENEK---LKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLT-- 326 + LEK+ + K+ + E+ L+ + ++ K +E ++ + + +L +E+ A +L Sbjct: 969 LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKI 1028 Query: 327 -NHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASL 385 N E + + K + E+ K R +D DL D I L A + Sbjct: 1029 RNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT---DLQDQIAELQ-------AQI 1078 Query: 386 NGLEIIWAEY------SLAQENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVDES 439 + L++ A+ +LA+ + +T + + N L R E+Q ++ EDF E +++ Sbjct: 1079 DELKLQLAKKEEELQGALARGDDET---LHKNNALKVVR-ELQAQIAELQEDF--ESEKA 1132 Query: 440 SLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKCDKREEFTSVRSETDASLHR 499 S NK K +DLS LEA+ + ++ ++ ++ + + +E ++ + Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQEL---RTKREQEVAELKKALEEETKN 1189 Query: 500 LVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSV---CKEL--EIALVDQGDAD 554 A Q + ++E + LEK + + KEL E+ ++ Q A+ Sbjct: 1190 HEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAE 1249 Query: 555 KEIISNTYSQVLQKIHSE----ERL---IATVQAKYKDSIEFKKQLIEYLNKS--PSVDH 605 E +Q++H++ +RL +A +K ++ ++ L+E K Sbjct: 1250 SEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKD 1309 Query: 606 LLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIYHEREE 665 S++ L+ + LL+ + +K NL S+I +++EE N QE E EE Sbjct: 1310 AASLESQLQDTQELLQEETRQKLNL-------SSRIRQLEEE-----KNSLQEQQEEEEE 1357 Score = 39.3 bits (90), Expect = 0.019 Identities = 49/207 (23%), Positives = 94/207 (45%), Gaps = 13/207 (6%) Query: 278 KQDQKLIEENEKLKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYI 337 ++ +L +E + K ALL+ + LE ++ Q+ +EL++E+ + ++L N + Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ-SNMELLNDRFRKTTLQV 1766 Query: 338 DTRMKNLAAKMEILKEMRHVDISV-RFGKDLSDAIQVLDEGCFTT--PASLNGLE--IIW 392 DT LAA+ ++ + + R K+L +Q L EG + A+++ LE I Sbjct: 1767 DTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQEL-EGAVKSKFKATISALEAKIGQ 1825 Query: 393 AEYSLAQENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVDE--SSLNKRLKTLQD 450 E L QE + + N L+ + + ++++M VED D+ + K ++ Sbjct: 1826 LEEQLEQE----AKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQ 1881 Query: 451 LSVSLEAVYGQAKEGANSDEILKKFYD 477 L LE +A S L++ D Sbjct: 1882 LKRQLEEAEEEATRANASRRKLQRELD 1908 >gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform 1 [Homo sapiens] Length = 556 Score = 47.0 bits (110), Expect = 9e-05 Identities = 32/88 (36%), Positives = 43/88 (48%), Gaps = 5/88 (5%) Query: 815 VAQGLHTLHKADIIHGSLHQNNVFALNREQGI-VGDFDFTKSVS---QRASVNMMVGDLS 870 + L LH IIH L N+ LN + I + DF K +S ++A N VG Sbjct: 189 IVSALEYLHGKGIIHRDLKPENIL-LNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQ 247 Query: 871 LMSPELKMGKPASPGSDLYAYGCLLLWL 898 +SPEL K A SDL+A GC++ L Sbjct: 248 YVSPELLTEKSACKSSDLWALGCIIYQL 275 >gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent protein kinase-1 [Homo sapiens] Length = 471 Score = 47.0 bits (110), Expect = 9e-05 Identities = 32/88 (36%), Positives = 43/88 (48%), Gaps = 5/88 (5%) Query: 815 VAQGLHTLHKADIIHGSLHQNNVFALNREQGI-VGDFDFTKSVS---QRASVNMMVGDLS 870 + L LH IIH L N+ LN + I + DF K +S ++A N VG Sbjct: 208 IVSALEYLHGKGIIHRDLKPENIL-LNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQ 266 Query: 871 LMSPELKMGKPASPGSDLYAYGCLLLWL 898 +SPEL K A SDL+A GC++ L Sbjct: 267 YVSPELLTEKSACKSSDLWALGCIIYQL 294 >gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo sapiens] Length = 396 Score = 47.0 bits (110), Expect = 9e-05 Identities = 32/88 (36%), Positives = 43/88 (48%), Gaps = 5/88 (5%) Query: 815 VAQGLHTLHKADIIHGSLHQNNVFALNREQGI-VGDFDFTKSVS---QRASVNMMVGDLS 870 + L LH IIH L N+ LN + I + DF K +S ++A N VG Sbjct: 162 IVSALEYLHGKGIIHRDLKPENIL-LNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQ 220 Query: 871 LMSPELKMGKPASPGSDLYAYGCLLLWL 898 +SPEL K A SDL+A GC++ L Sbjct: 221 YVSPELLTEKSACKSSDLWALGCIIYQL 248 >gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] Length = 1030 Score = 47.0 bits (110), Expect = 9e-05 Identities = 38/146 (26%), Positives = 66/146 (45%), Gaps = 9/146 (6%) Query: 783 YLMVPYYPRANLNAVQANMP--LNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL 840 YL+ Y + L ++ MP + E+ + + + +H HK DI+H + N+ Sbjct: 86 YLVFEYVEKNMLELLE-EMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLIS 144 Query: 841 NREQGIVGDFDFTKSVSQ--RASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWL 898 + + + DF F +++S+ A+ V SPEL +G P D+++ GC+L L Sbjct: 145 HNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGEL 204 Query: 899 SVQNQEFEINKDGIPKVDQFHLDDKV 924 S F G ++DQ KV Sbjct: 205 SDGQPLF----PGESEIDQLFTIQKV 226 >gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] Length = 1030 Score = 47.0 bits (110), Expect = 9e-05 Identities = 38/146 (26%), Positives = 66/146 (45%), Gaps = 9/146 (6%) Query: 783 YLMVPYYPRANLNAVQANMP--LNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL 840 YL+ Y + L ++ MP + E+ + + + +H HK DI+H + N+ Sbjct: 86 YLVFEYVEKNMLELLE-EMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLIS 144 Query: 841 NREQGIVGDFDFTKSVSQ--RASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWL 898 + + + DF F +++S+ A+ V SPEL +G P D+++ GC+L L Sbjct: 145 HNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGEL 204 Query: 899 SVQNQEFEINKDGIPKVDQFHLDDKV 924 S F G ++DQ KV Sbjct: 205 SDGQPLF----PGESEIDQLFTIQKV 226 >gi|118498362 kinectin 1 isoform b [Homo sapiens] Length = 1306 Score = 45.8 bits (107), Expect = 2e-04 Identities = 83/403 (20%), Positives = 167/403 (41%), Gaps = 66/403 (16%) Query: 274 LEKIKQDQKLIEENEKLKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTNHLEYTL 333 ++ ++ +QK + + E L+ + +LE +AL+ +++Q ++ + +A+V L L Sbjct: 551 MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV-----LAEEL 605 Query: 334 KTYIDTRMKNLAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWA 393 I + K + + L R D ++L D IQ ++ F A + L+ + Sbjct: 606 HKVIAEKDKQIKQTEDSLASER--DRLTSKEEELKD-IQNMN---FLLKAEVQKLQALAN 659 Query: 394 EYSLAQ---ENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDF-ILEVDESSLNKRLKTLQ 449 E + A E ++ YV + I + + ++Q ++ +E+F IL +L ++ LQ Sbjct: 660 EQAAAAHELEKMQQSVYVKDDKIRLLE-EQLQHEISNKMEEFKILNDQNKALKSEVQKLQ 718 Query: 450 DLSVSLEAVYGQAKEGANSDEILKKFYDWKCDKREEFTSVRSETDASLHRLVAWFQRTLK 509 L E N D + E+ E D LK Sbjct: 719 TL----------VSEQPNKDVV------------EQMEKCIQEKD-----------EKLK 745 Query: 510 VFDLSVEGSLISEDAMDNIDEILEKTESSVCKELEIALVDQGDADKEIISNTYSQVLQKI 569 + +E LI + + SS+ KE++ Q D+ ++ ++ + I Sbjct: 746 TVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQN--DQVSFASLVEELKKVI 803 Query: 570 HSEERLIATVQAKYKDSIEFKKQLIEYLNKSPSVDHLLSIKKTLKSLKALLRWKLVE--- 626 H ++ I +V+ + +L++ NK +V LSI ++ L+ LL+ K + Sbjct: 804 HEKDGKIKSVEEL------LEAELLKVANKEKTVQ--LSITSKVQELQNLLKGKEEQMNT 855 Query: 627 -KSNLEESDDP---DGSQIEKIKEEITQLRNNVFQEIYHEREE 665 K+ LEE + G ++ ++EE L+ +V + H +E Sbjct: 856 MKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKE 898 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.132 0.374 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 34,994,114 Number of Sequences: 37866 Number of extensions: 1521383 Number of successful extensions: 5889 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 101 Number of HSP's successfully gapped in prelim test: 501 Number of HSP's that attempted gapping in prelim test: 5131 Number of HSP's gapped (non-prelim): 1172 length of query: 996 length of database: 18,247,518 effective HSP length: 112 effective length of query: 884 effective length of database: 14,006,526 effective search space: 12381768984 effective search space used: 12381768984 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.