Guide to the Human Genome
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Search of human proteins with 170784856

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|170784856 serine/threonine kinase 31 isoform b [Homo
sapiens]
         (996 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|170784859 serine/threonine kinase 31 isoform b [Homo sapiens]     1970   0.0  
gi|14602443 serine/threonine kinase 31 isoform a [Homo sapiens]      1970   0.0  
gi|170784856 serine/threonine kinase 31 isoform b [Homo sapiens]     1970   0.0  
gi|38505161 tudor domain containing 1 [Homo sapiens]                   57   7e-08
gi|30039692 NIMA-related kinase 8 [Homo sapiens]                       57   9e-08
gi|58197558 tudor domain containing 6 [Homo sapiens]                   54   6e-07
gi|71061468 centromere protein E [Homo sapiens]                        53   1e-06
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho...    53   1e-06
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    53   2e-06
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             53   2e-06
gi|208431829 eukaryotic translation initiation factor 2-alpha ki...    52   2e-06
gi|208431827 eukaryotic translation initiation factor 2-alpha ki...    52   2e-06
gi|4506103 eukaryotic translation initiation factor 2-alpha kina...    52   2e-06
gi|110349799 testis-specific protein kinase 2 [Homo sapiens]           51   5e-06
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H...    51   6e-06
gi|223671888 interleukin-1 receptor-associated kinase 4 isoform ...    49   2e-05
gi|223671885 interleukin-1 receptor-associated kinase 4 isoform ...    49   2e-05
gi|223671883 interleukin-1 receptor-associated kinase 4 isoform ...    49   2e-05
gi|166795293 interleukin-1 receptor-associated kinase 4 isoform ...    49   2e-05
gi|166795295 interleukin-1 receptor-associated kinase 4 isoform ...    49   2e-05
gi|4758650 kinesin family member 5C [Homo sapiens]                     49   3e-05
gi|148839316 NIMA-related kinase 4 [Homo sapiens]                      49   3e-05
gi|66932999 testis-specific protein kinase 1 [Homo sapiens]            48   5e-05
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    47   7e-05
gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform...    47   9e-05
gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent ...    47   9e-05
gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo ...    47   9e-05
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]              47   9e-05
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]               47   9e-05
gi|118498362 kinectin 1 isoform b [Homo sapiens]                       46   2e-04

>gi|170784859 serine/threonine kinase 31 isoform b [Homo sapiens]
          Length = 996

 Score = 1970 bits (5104), Expect = 0.0
 Identities = 996/996 (100%), Positives = 996/996 (100%)

Query: 1   MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK 60
           MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK
Sbjct: 1   MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK 60

Query: 61  IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY 120
           IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY
Sbjct: 61  IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY 120

Query: 121 KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV 180
           KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV
Sbjct: 121 KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV 180

Query: 181 LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM 240
           LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM
Sbjct: 181 LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM 240

Query: 241 TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES 300
           TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES
Sbjct: 241 TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES 300

Query: 301 YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS 360
           YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS
Sbjct: 301 YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS 360

Query: 361 VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE 420
           VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE
Sbjct: 361 VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE 420

Query: 421 MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC 480
           MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC
Sbjct: 421 MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC 480

Query: 481 DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC 540
           DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC
Sbjct: 481 DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC 540

Query: 541 KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS 600
           KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS
Sbjct: 541 KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS 600

Query: 601 PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY 660
           PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY
Sbjct: 601 PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY 660

Query: 661 HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR 720
           HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR
Sbjct: 661 HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR 720

Query: 721 PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP 780
           PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP
Sbjct: 721 PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP 780

Query: 781 MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL 840
           MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL
Sbjct: 781 MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL 840

Query: 841 NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV 900
           NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV
Sbjct: 841 NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV 900

Query: 901 QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP 960
           QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP
Sbjct: 901 QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP 960

Query: 961 EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC 996
           EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC
Sbjct: 961 EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC 996


>gi|14602443 serine/threonine kinase 31 isoform a [Homo sapiens]
          Length = 1019

 Score = 1970 bits (5104), Expect = 0.0
 Identities = 996/996 (100%), Positives = 996/996 (100%)

Query: 1    MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK 60
            MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK
Sbjct: 24   MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK 83

Query: 61   IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY 120
            IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY
Sbjct: 84   IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY 143

Query: 121  KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV 180
            KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV
Sbjct: 144  KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV 203

Query: 181  LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM 240
            LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM
Sbjct: 204  LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM 263

Query: 241  TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES 300
            TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES
Sbjct: 264  TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES 323

Query: 301  YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS 360
            YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS
Sbjct: 324  YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS 383

Query: 361  VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE 420
            VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE
Sbjct: 384  VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE 443

Query: 421  MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC 480
            MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC
Sbjct: 444  MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC 503

Query: 481  DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC 540
            DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC
Sbjct: 504  DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC 563

Query: 541  KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS 600
            KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS
Sbjct: 564  KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS 623

Query: 601  PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY 660
            PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY
Sbjct: 624  PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY 683

Query: 661  HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR 720
            HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR
Sbjct: 684  HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR 743

Query: 721  PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP 780
            PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP
Sbjct: 744  PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP 803

Query: 781  MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL 840
            MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL
Sbjct: 804  MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL 863

Query: 841  NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV 900
            NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV
Sbjct: 864  NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV 923

Query: 901  QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP 960
            QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP
Sbjct: 924  QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP 983

Query: 961  EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC 996
            EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC
Sbjct: 984  EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC 1019


>gi|170784856 serine/threonine kinase 31 isoform b [Homo sapiens]
          Length = 996

 Score = 1970 bits (5104), Expect = 0.0
 Identities = 996/996 (100%), Positives = 996/996 (100%)

Query: 1   MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK 60
           MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK
Sbjct: 1   MDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNK 60

Query: 61  IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY 120
           IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY
Sbjct: 61  IYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKY 120

Query: 121 KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV 180
           KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV
Sbjct: 121 KLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEV 180

Query: 181 LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM 240
           LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM
Sbjct: 181 LKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKM 240

Query: 241 TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES 300
           TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES
Sbjct: 241 TLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLES 300

Query: 301 YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS 360
           YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS
Sbjct: 301 YKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDIS 360

Query: 361 VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE 420
           VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE
Sbjct: 361 VRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNE 420

Query: 421 MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC 480
           MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC
Sbjct: 421 MQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKC 480

Query: 481 DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC 540
           DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC
Sbjct: 481 DKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVC 540

Query: 541 KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS 600
           KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS
Sbjct: 541 KELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKS 600

Query: 601 PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY 660
           PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY
Sbjct: 601 PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY 660

Query: 661 HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR 720
           HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR
Sbjct: 661 HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKR 720

Query: 721 PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP 780
           PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP
Sbjct: 721 PLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDP 780

Query: 781 MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL 840
           MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL
Sbjct: 781 MAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL 840

Query: 841 NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV 900
           NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV
Sbjct: 841 NREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSV 900

Query: 901 QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP 960
           QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP
Sbjct: 901 QNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNP 960

Query: 961 EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC 996
           EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC
Sbjct: 961 EKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC 996


>gi|38505161 tudor domain containing 1 [Homo sapiens]
          Length = 1189

 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 54/179 (30%), Positives = 83/179 (46%), Gaps = 10/179 (5%)

Query: 14  VGSHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDP--NKIYGGLFSEDQC 71
           V +HI+    F+ Q +   + + ++  SLS+ C Q      +  P    I    FSED  
Sbjct: 499 VVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQLPP-RSDFYPAIGDICCAQFSEDDQ 557

Query: 72  WYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVE-IPLELQFSSVAKKYKLWGLHIPSD 130
           WYR  VL   S E  LV Y+DYGN EIL+   +   IP  L+    A K  L G+  PS 
Sbjct: 558 WYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVK-PSL 616

Query: 131 QEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGT---VIAQAEYGSVDIGEEVLKKGFA 186
              T   +    +  L+  K I +++    E+ +   +I ++E   V + + +L  GFA
Sbjct: 617 GIWT--PEAICLMKKLVQNKIITVKVVDKLENSSLVELIDKSETPHVSVSKVLLDAGFA 673



 Score = 36.2 bits (82), Expect = 0.16
 Identities = 32/141 (22%), Positives = 59/141 (41%), Gaps = 17/141 (12%)

Query: 8   DKVEDVVGSHIEDAVTFWAQSINRN--KDIMKIGCSLSEVCPQASSVLGNLDPNKIYGGL 65
           D+  DVV   I     F+   +  +  K +  +  SL+E C Q        +  +     
Sbjct: 713 DQTVDVVVCVIYSPGEFYCHVLKEDALKKLNDLNKSLAEHCQQKLPNGFKAEIGQPCCAF 772

Query: 66  FSEDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDI-------VEIP---LELQFSS 115
           F+ D  WYR  V +I+      V ++DYGN E +   ++       + +P   +  Q + 
Sbjct: 773 FAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLAD 832

Query: 116 VAKKYKLWGLHIPSDQEVTQF 136
           +  + K W     S++ +T+F
Sbjct: 833 IQSRNKHW-----SEEAITRF 848



 Score = 30.4 bits (67), Expect = 8.6
 Identities = 14/35 (40%), Positives = 21/35 (60%), Gaps = 1/35 (2%)

Query: 66  FSEDQCWYRCKVLKI-ISVEKCLVRYIDYGNTEIL 99
           ++ DQ W R  +  + +  +K  V YIDYGN EI+
Sbjct: 323 YTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEII 357


>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
          Length = 692

 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 36/111 (32%), Positives = 57/111 (51%), Gaps = 3/111 (2%)

Query: 798 QANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFALNREQGIV--GDFDFTKS 855
           + N  L  E  L     +   LH +H   I+H  L   N+  L++ + +V  GDF  +K 
Sbjct: 95  RCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNIL-LDKHRMVVKIGDFGISKI 153

Query: 856 VSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWLSVQNQEFE 906
           +S ++    +VG    +SPEL  GKP +  SD++A GC+L  L+   + FE
Sbjct: 154 LSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFE 204


>gi|58197558 tudor domain containing 6 [Homo sapiens]
          Length = 2096

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 65/221 (29%), Positives = 100/221 (45%), Gaps = 40/221 (18%)

Query: 5    THYDKV---EDVVGSHIEDAVTFWAQSINRNKDIMK-IGCSLSEVCPQASSVLGNLDPNK 60
            TH  K+   E V  +HI+D  TF+ Q + RN +I++ + CS++    Q S VL NL  + 
Sbjct: 979  THDMKIGSEELVYITHIDDPWTFYCQ-LARNANILEQLSCSIT----QLSKVLLNLKTSP 1033

Query: 61   IYGGLFS----EDQCWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIP------LE 110
            +  G        D  WYR  V   I  E   V ++D+GN  ++   D++ IP      L 
Sbjct: 1034 LNPGTLCLAKYTDGNWYRGIV---IEKEPKKVFFVDFGNIYVVTSDDLLPIPSDAYDVLL 1090

Query: 111  LQFSSVAKKYKLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAE 170
            L   +V         HIP  +EV  + Q T      I +K +K  + A   DGT+I +  
Sbjct: 1091 LPMQAVRCSLSDIPDHIP--EEVVVWFQET------ILDKSLKALVVAKDPDGTLIIELY 1142

Query: 171  YGSVDIGEEVLKK----GFAEKCR------LASRTDICEEK 201
              ++ I   + KK     + ++ R      L S T+  EEK
Sbjct: 1143 GDNIQISASINKKLGLLSYKDRIRKKESEVLCSTTETLEEK 1183



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 26/95 (27%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 16   SHIEDAVTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGN-LDPNKIYGGLFSEDQCWYR 74
            SHI D   F+ Q I    +I  +   L+ V  +    +G  L    +   +F ED  WYR
Sbjct: 1312 SHINDLSDFYVQLIEDEAEISHLSERLNSVKTRPEYYVGPPLQRGDMICAVFPEDNLWYR 1371

Query: 75   CKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPL 109
              + +    +   V++IDYGN  +++ + I  + L
Sbjct: 1372 AVIKEQQPNDLLSVQFIDYGNVSVVHTNKIGRLDL 1406



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 30/128 (23%), Positives = 54/128 (42%), Gaps = 13/128 (10%)

Query: 16  SHIEDAVTFWAQSINRNKDIMKIGCSLSEVC-----PQASSVLGNLDPNKIYGGLFSEDQ 70
           S++E+   FW Q     + +  +   +   C     P   + L  L    +       ++
Sbjct: 779 SYVENPGYFWCQLTRNIQGLKTLMSDIQYYCKNTAAPHQRNTLACLAKRTV-------NR 831

Query: 71  CWYRCKVLKIISVEKCLVRYIDYGNTEILNRSDIVEIPLE-LQFSSVAKKYKLWGLHIPS 129
            W R  +  I SVE   V ++DYG+ E+++  +I  I  E L+  + A +  L+ L  P 
Sbjct: 832 QWSRALISGIQSVEHVNVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSLYNLIQPV 891

Query: 130 DQEVTQFD 137
            Q    +D
Sbjct: 892 GQNPFVWD 899


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 89/447 (19%), Positives = 197/447 (44%), Gaps = 40/447 (8%)

Query: 243  DLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKT---EKDALLE 299
            ++ +  +  N +    E     D    + + +E+++ ++K  E  E++K+   E+D L  
Sbjct: 1297 EVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKT 1356

Query: 300  SYKALELKVEQIAQELQQEKAAAVDLTNHLEYTLK-TYIDTRMKNLAAKMEILKEMRHVD 358
              +ALE+K +Q+ + +++  A   +  +  E +L     D     + ++ME  K      
Sbjct: 1357 IKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSAL 1416

Query: 359  ISVRFGK-DLSDAIQVLDEGCFTTPASLNGL----EIIWAEYSLAQENIK--------TC 405
            + +      LS  +Q   +   +     + L    E++ +E    +ENIK        T 
Sbjct: 1417 LRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETE 1476

Query: 406  EYVSEGNILIAQRNEMQQKLYMSVEDFILEVDESSLNKRLKTLQD-LSVSLEAVYGQAKE 464
            E +   +  + ++ E   +L +++ +   E + S++ K+L+ + D L   ++ +Y + +E
Sbjct: 1477 EELKVAHCCLKEQEETINELRVNLSE--KETEISTIQKQLEAINDKLQNKIQEIY-EKEE 1533

Query: 465  GANSDEILKKFYDWKCDKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDA 524
              N  +I +     K ++ ++F   R   D++L  + +      K+ +L+       +++
Sbjct: 1534 QFNIKQISE--VQEKVNELKQFKEHRKAKDSALQSIES------KMLELTNR----LQES 1581

Query: 525  MDNIDEILEKTESSVCKELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYK 584
             + I  ++++ E    K ++ AL  + D  KE   NT   V +   S+E+    ++    
Sbjct: 1582 QEEIQIMIKEKEE--MKRVQEALQIERDQLKE---NTKEIVAKMKESQEKEYQFLKMTAV 1636

Query: 585  DSIEFKKQLIEYLNKSPSVD--HLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIE 642
            +  + K   IE+L +       +L +I+     L  +L   L E  ++ +  D   S  E
Sbjct: 1637 NETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEE 1696

Query: 643  KIKEEITQLRNNVFQEIYHEREEYEML 669
             +K E  QL+ N+ + I  + E+ E L
Sbjct: 1697 TLKVERDQLKENLRETITRDLEKQEEL 1723



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 88/444 (19%), Positives = 174/444 (39%), Gaps = 57/444 (12%)

Query: 272  VSLEKIKQDQKLIEENEKLKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTNHLEY 331
            V+L+  ++   L  EN +LK +   L  +YK +E  ++    +L+ +K   VDL   L+ 
Sbjct: 633  VALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQS 692

Query: 332  T------LKTYIDTRM-KNLAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPAS 384
                   L + ID ++ K+L   +E+  E +  D+     K++ +   + +E    +   
Sbjct: 693  AFNEITKLTSLIDGKVPKDLLCNLEL--EGKITDLQKELNKEVEENEALREEVILLSELK 750

Query: 385  LNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVDE------ 438
                E+      +  ++ +     SE + L ++    + ++   +E+     D+      
Sbjct: 751  SLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQS 810

Query: 439  --SSLNKRLKTLQDLSVSLEAVY---------------GQAKEGANSDE---ILKKFYDW 478
               S ++  +  + L +  E  Y                 +KE    D     LK    +
Sbjct: 811  NYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSY 870

Query: 479  KCDKREEFTSVRSETDASLHRLVAWFQ-RTLKVFDLSVEGSLISEDAMDNIDEILEKT-E 536
            K  + +E T    E    + +L    + R   +  +  E +LI+E     ++E+   T E
Sbjct: 871  KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQE 930

Query: 537  SSVCKELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEY 596
                K+L+ +L  + D           Q+   IH    +    Q + ++++E  KQ  E 
Sbjct: 931  KDDLKQLQESLQIERD-----------QLKSDIHDTVNMNIDTQEQLRNALESLKQHQET 979

Query: 597  LNK-----SPSVDHLLSIKKTLKSLKALLRWKLV---EKSNLEESDDPDGSQIEKIKEEI 648
            +N      S  V   L +++     K   + K+V   +K +LE  +    +   K  E I
Sbjct: 980  INTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII 1039

Query: 649  TQLRNNVFQEIYHEREEYEMLTSL 672
             Q R  +F  I  + E  +ML S+
Sbjct: 1040 EQQR-KIFSLIQEKNELQQMLESV 1062



 Score = 37.7 bits (86), Expect = 0.054
 Identities = 124/587 (21%), Positives = 236/587 (40%), Gaps = 89/587 (15%)

Query: 223  RSNQSTFSRPKGHLSEKMTLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEK-IKQDQ 281
            +  Q T  + +G +SEK       + D  N     +E +     N    ++L+K + + Q
Sbjct: 1784 KEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQ 1843

Query: 282  KLIEENEKLKTE-KDALLESYKALELKVEQIAQELQQ--EKAAAV----DLTNHLEYTLK 334
            K + E E+LK + KD  L   K LE++   +AQ+L +  E+  +V    D    +E TLK
Sbjct: 1844 KKVSEMEQLKKQIKDQSLTLSK-LEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLK 1902

Query: 335  TYIDTRMKNL----AAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGL-- 388
               D   ++L    A  +EI +E++   +     K+  + +  L E        ++ +  
Sbjct: 1903 LERDQLKESLQETKARDLEIQQELKTARM---LSKEHKETVDKLREKISEKTIQISDIQK 1959

Query: 389  -------EIIWAEYSLAQENIKTCEYVSEGNILIAQRNEMQQ-KLYMSVEDFILE---VD 437
                   E+      L ++ ++      + N+   + NEM+Q K     ++  ++   +D
Sbjct: 1960 DLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMD 2019

Query: 438  ESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKCDKREEFTSVRS--ETDA 495
               L K+L        SLE +   AKE    DE+ +     K ++ +   ++R     D 
Sbjct: 2020 NFQLTKKLHE------SLEEIRIVAKE---RDELRRIKESLKMERDQFIATLREMIARDR 2070

Query: 496  SLH------RLVAWFQRTLKVFDLSVEGSLISE-----DAMDNIDEILEKTESSVCKELE 544
              H      RL++  Q+ L    L  + S I E       MD+  E L +    + KE+E
Sbjct: 2071 QNHQVKPEKRLLSDGQQHL-TESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIE 2129

Query: 545  IALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQA--KYKDSIEFKKQLIEYLNKSPS 602
                 Q +    + +N     LQ  H E+   A  +   ++   ++  K ++ Y+ K   
Sbjct: 2130 F----QKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185

Query: 603  VDHLLSIKKTLKSLKALLRWK--LVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY 660
              H    K  +  +  + + K  L++  +L++  D           E+  L+ N   +++
Sbjct: 2186 EQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVP-------SRELRDLKLNQNMDLH 2238

Query: 661  HEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDL---LDAEPMKELS 717
             E    E+L   ++  FP +     ++     +++   +T  LE  L    D E +K   
Sbjct: 2239 IE----EILKDFSESEFPSIKTEFQQV-----LSNRKEMTQFLEEWLNTRFDIEKLKNGI 2289

Query: 718  SKRP----LVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWRE 760
             K       V +  N +II +   S + +      ER+AT  + W +
Sbjct: 2290 QKENDRICQVNNFFNNRIIAIMNESTEFE------ERSATISKEWEQ 2330



 Score = 31.2 bits (69), Expect = 5.1
 Identities = 78/392 (19%), Positives = 164/392 (41%), Gaps = 61/392 (15%)

Query: 281  QKLIEENEKLKTEK----DALLESYKALELKVEQIAQE---LQQEKAAAVDLTNHLEYTL 333
            + +I E E+LKT+     +  +E+ + L L  +++ ++   + QEK  A+     L  T 
Sbjct: 1060 ESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTC 1119

Query: 334  KTYIDTRMKNLAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWA 393
                +   K L  K + L+E +   ++V+  +++S+  + ++E        +  L+    
Sbjct: 1120 DRLAEVEEK-LKEKSQQLQEKQQQLLNVQ--EEMSEMQKKINE--------IENLKNELK 1168

Query: 394  EYSLAQENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVDESSLNKRLKTLQDLSV 453
               L  E+++T            +R E+ QKL  + E+        S+ K  K L++L  
Sbjct: 1169 NKELTLEHMET------------ERLELAQKLNENYEEV------KSITKERKVLKELQK 1210

Query: 454  SLEA----VYGQAKE----GANSDEILKKFYDWKCDKREEFTSVRSETDASLHRLVAWFQ 505
            S E     + G  +E    G  + E LK  +    + +E    +R        +++    
Sbjct: 1211 SFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQD 1270

Query: 506  RTLKVFDLSVEGSLISE--DAMDNIDEILEKTESSVCKELEIALVDQGDADKEIISNTYS 563
                   L  E  ++ E  + + N+ E+ E  E+    ELE+        D   ++    
Sbjct: 1271 LEKSHTKLQEEIPVLHEEQELLPNVKEVSETQET--MNELELLTEQSTTKDSTTLARIEM 1328

Query: 564  QVL---QKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKSPSVDHLLSIKKTLKSLKALL 620
            + L   +K    +  I ++  K +D+++  K+ +E +      +H   I++TL  ++   
Sbjct: 1329 ERLRLNEKFQESQEEIKSL-TKERDNLKTIKEALE-VKHDQLKEH---IRETLAKIQE-S 1382

Query: 621  RWKLVEKSNLEESDDPDGSQIEKIKEEITQLR 652
            + K  +  N++E D    ++  KI  E+ Q +
Sbjct: 1383 QSKQEQSLNMKEKD----NETTKIVSEMEQFK 1410


>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
           sapiens]
          Length = 966

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 32/129 (24%), Positives = 62/129 (48%), Gaps = 2/129 (1%)

Query: 770 LIFLFLCKSDPMAYLMVPYYPRANLNAV-QANMPLNSEETLKVMKGVAQGLHTLHKADII 828
           + F  +C   P   +++ Y     L  V +A   +     +    G+A G++ LH   II
Sbjct: 217 IAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKII 276

Query: 829 HGSLHQNNVFALNREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDL 888
           H  L   NV   + +   + DF  +K +S +++     G ++ M+PE+   +P S   D+
Sbjct: 277 HRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDI 336

Query: 889 YAYGCLLLW 897
           +++G ++LW
Sbjct: 337 WSFG-VVLW 344


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 124/564 (21%), Positives = 226/564 (40%), Gaps = 95/564 (16%)

Query: 236  LSEKMTLDLKDENDAGNLITFPKESLAVGDFN----LGSNVSLE-KIKQDQKLIEENEKL 290
            L EKM   L+++ND    +    E+L   +      + S + LE K+K+  + +EE E++
Sbjct: 877  LEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEM 936

Query: 291  KTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEI 350
             +E   L+   + LE K   + +++       ++LT       K   + ++KNL+ +M  
Sbjct: 937  NSE---LVAKKRNLEDKCSSLKRDIDD-----LELTLTKVEKEKHATENKVKNLSEEMTA 988

Query: 351  LKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSE 410
            L+E  ++    +  K L +A Q   +        +NGL  I A+     +++       E
Sbjct: 989  LEE--NISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDL-------E 1039

Query: 411  GNILIAQRNEMQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDE 470
            G++      E ++KL   +E             + K   DL +S E++     +    +E
Sbjct: 1040 GSL------EQEKKLRADLE-----------RAKRKLEGDLKMSQESIMDLENDKQQIEE 1082

Query: 471  ILKKFYDWKCDKREEFTSVRSETD-ASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNID 529
             LKK       K  E + ++++ D   +H L   FQ+ +K     +E      +A   + 
Sbjct: 1083 KLKK-------KEFELSQLQAKIDDEQVHSLQ--FQKKIKELQARIEELEEEIEAEHTLR 1133

Query: 530  EILEKTESSVCKELEIALVDQGDADKEIISNTYSQVLQKIHSEERLI--------ATVQA 581
              +EK  S + +ELE    +  +  +E    T +Q+      E            AT+Q 
Sbjct: 1134 AKIEKQRSDLARELE----EISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQH 1189

Query: 582  KYKDSIEFKKQLIEYLNKSPSVDHLLSIKKTLKSLKALLRWKLVE-----------KSNL 630
            +   +   KKQ          +D+L  +K+ L+  K+ L+ ++ +           KSN+
Sbjct: 1190 EATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNI 1249

Query: 631  EESDDPDGSQIEKIK---EEITQLRNNVFQ----------EIYHEREEYEMLTSLAQK-- 675
            E +      Q  +IK   E+ TQL +++            E+ H  EE E L S   K  
Sbjct: 1250 ERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSK 1309

Query: 676  -----WFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSSKRPLVR--SEVN 728
                    EL     E    K   +  L +   + DLL  +  +E  +K  L R  S+ N
Sbjct: 1310 QALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKAN 1369

Query: 729  GQIILLK-GYSVDVDTEAKVIERA 751
             ++   +  Y  D     + +E A
Sbjct: 1370 SEVAQWRTKYETDAIQRTEELEEA 1393



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 78/382 (20%), Positives = 154/382 (40%), Gaps = 41/382 (10%)

Query: 284  IEENEKLKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKN 343
            +EE E L ++   L +S +AL  ++E++ +++++E  A   + + L+ + +   D   + 
Sbjct: 1295 VEEKESLISQ---LTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSS-RHDCDLLREQ 1350

Query: 344  LAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIK 403
               + E   E++         K  S+  Q   +  + T A     E+  A+  LAQ   +
Sbjct: 1351 YEEEQEAKAELQRA-----LSKANSEVAQWRTK--YETDAIQRTEELEEAKKKLAQRLQE 1403

Query: 404  TCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAK 463
              E     N   A   + +Q+L   VED                ++DL  S  A     K
Sbjct: 1404 AEENTETANSKCASLEKTKQRLQGEVEDL---------------MRDLERSHTACATLDK 1448

Query: 464  EGANSDEILKKFYDWKCDKREEFTSVRSETDASLHRLVAWFQRTLKVFD----LSVEGSL 519
            +  N D++L ++     + + E  + + E+ +    L        +V D    L  E   
Sbjct: 1449 KQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKN 1508

Query: 520  ISEDAMDNIDEILEKTESSVCKELEIALVDQGDADKEIISNTYSQVLQKIHSEERL---- 575
            + E+  D  ++I E  ++    E    LV+Q  +D ++        L+  H E ++    
Sbjct: 1509 LQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLE--HEESKILRVQ 1566

Query: 576  --IATVQAKYKDSIEFKKQLIEYL--NKSPSVDHLLSI-KKTLKSLKALLRWKLVEKSNL 630
              ++ V+++    +  K + IE L  N   + + L S+    ++S    LR K   + +L
Sbjct: 1567 LELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDL 1626

Query: 631  EESDDPDGSQIEKIKEEITQLR 652
             E +   G    ++ E    LR
Sbjct: 1627 NEMEIQLGHSNRQMAETQKHLR 1648


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 101/456 (22%), Positives = 190/456 (41%), Gaps = 80/456 (17%)

Query: 281  QKLIEENEKLKTEKDALLESYKALELKVEQIAQEL-----------QQEKAAAVDLTNHL 329
            Q  + E +K+K EK+AL+     ++ K+ +++  L           Q+ KAA +DL    
Sbjct: 835  QTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTC 894

Query: 330  EYTLKTYIDTRMKNLAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGL- 388
            +  LK  +  +M+N       LKE + +  S+   K+ S  +++           LN + 
Sbjct: 895  K-ELKHQLQVQMEN------TLKEQKELKKSLEKEKEASHQLKL----------ELNSMQ 937

Query: 389  -EIIWAEYSLAQENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVD-------ESS 440
             ++I A+ +L Q   +  E   +GNI   +++  Q+K  +      L++        E+ 
Sbjct: 938  EQLIQAQNTLKQNEKE--EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK 995

Query: 441  LNKRL-KTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKCDKREEFTSVRSETDASLHR 499
            L ++L +  Q+L+   E +         S E  K+       +  E  + R +  +   +
Sbjct: 996  LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055

Query: 500  LVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVCKELEI--ALVDQGDADKEI 557
            L                 SL  ED + N ++I    ++ + +EL+   A ++Q  A KE 
Sbjct: 1056 L-----------------SLAQEDLISNRNQI--GNQNKLIQELKTAKATLEQDSAKKEQ 1096

Query: 558  ISNTYSQVLQKIHSE----ERLIATVQAKYKDSIEFK---KQLIEYLNKSPSVDHLLSIK 610
                  + LQ I  E    E+ +   ++K  +  E K   ++ I  LN+      L SIK
Sbjct: 1097 QLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK 1156

Query: 611  K--TLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIYHEREEYEM 668
            +   LK  K LL   + +K  L+   D   + +E+ K     L++ V      ++EE E+
Sbjct: 1157 EITNLKDAKQLL---IQQKLELQGKADSLKAAVEQEKRNQQILKDQV------KKEEEEL 1207

Query: 669  LTSLAQKWFP-ELPLLHPEIGLLKYMNSGGLLTMSL 703
                 +K       +   E+G+ K+  +   LTM +
Sbjct: 1208 KKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQI 1243



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 88/439 (20%), Positives = 166/439 (37%), Gaps = 89/439 (20%)

Query: 268 LGSNVSLEKIKQDQKLIEENEKLKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTN 327
           L  N++LE+ +       E+EKLK E   L   Y + E  + Q+  EL +          
Sbjct: 236 LMDNMTLERER-------ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQ 288

Query: 328 HLEYTLKTYIDTRMKNLAAKMEILK--------EMRHVDISVR--------FGKDLSDAI 371
            L+    +  +   KN      +LK        E +H + SV           KDL    
Sbjct: 289 ELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLD--C 346

Query: 372 QVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSE--------------------- 410
           Q L      +  SL+ + +  +E   A + +K  E +SE                     
Sbjct: 347 QQLQSRLSASETSLHRIHVELSEKGEATQKLK--EELSEVETKYQHLKAEFKQLQQQREE 404

Query: 411 ----GNILIAQRNEMQQKLYMSVEDF---------ILEVDESSLNKRLKTLQDLSVSLEA 457
               G  L ++ N++  KL  +               ++    L  + + + DL + L  
Sbjct: 405 KEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSR 464

Query: 458 VYGQAKEGANSDEILKKFYDWKCDKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEG 517
           +  Q KE   +   L+   D    + +E  +++  T A L       ++ L+        
Sbjct: 465 LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIG----- 519

Query: 518 SLISEDAMDNIDEILEKTESSVC---KELE--IALVDQGDADKEIISNTYSQVLQKIHSE 572
               +  + N++ +L+K++ ++    KE E   A +  G+ +  ++    +Q+ +K H+ 
Sbjct: 520 --DKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL----NQLQEKNHTL 573

Query: 573 ERLIATVQAKYKDSIEFKKQLIEYLNKSPSVDHLLSIKKTLKSLKALLRWKLVEKSNLEE 632
           +  +  +  K K+  E  KQ  E L+              ++  KA LR       +LE 
Sbjct: 574 QEQVTQLTEKLKNQSESHKQAQENLHDQ------------VQEQKAHLRAAQDRVLSLET 621

Query: 633 SDDPDGSQIEKIKEEITQL 651
           S +   SQ+ + KE+++QL
Sbjct: 622 SVNELNSQLNESKEKVSQL 640



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 106/529 (20%), Positives = 220/529 (41%), Gaps = 72/529 (13%)

Query: 283  LIEENEKLKTEKDALLESYKALELKVEQIAQELQQEK-------AAAVDLTNHLEYTLKT 335
            L ++ E+L+ +   L      ++   EQ  Q+LQQ++         A +L+  LE   + 
Sbjct: 721  LEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI 780

Query: 336  YIDTRMKNLAAKMEILKEMRHVDISVRFGKD-LSDAIQVLDEGCFTTPASLNGLEIIWAE 394
               TR+ +L  K E L+ ++         K  L    + L +        LN   I    
Sbjct: 781  VSSTRL-DLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN-RIQTTV 838

Query: 395  YSLAQENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVDES-----SLNKRLKTLQ 449
              L +  ++    ++E + +  + +++   L  S  +F  E  +       L K  K L+
Sbjct: 839  TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK 898

Query: 450  -DLSVSLEAVYGQAKEGANSDEILKKFYDWKCDKREEFTSVRSETDASLHRLVAWFQRTL 508
              L V +E    + KE       LKK  +    ++E    ++ E ++   +L+   Q TL
Sbjct: 899  HQLQVQMENTLKEQKE-------LKKSLE---KEKEASHQLKLELNSMQEQLIQ-AQNTL 947

Query: 509  KVFDLSVEGSLISEDAMDNIDEILEKTE------SSVCKELEIALVDQGDADKEIISNTY 562
            K      +     +    NI+E+ + +E       ++  EL+IA++ + + + + +    
Sbjct: 948  K------QNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK-LQQQL 1000

Query: 563  SQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKSPSVDHLLSIKKTLKSLKALL-- 620
            +Q  Q++ +E+  I+ +Q  Y+ S E  KQL        S   LL+ ++ LKS++  L  
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRES--ELLATRQDLKSVEEKLSL 1058

Query: 621  --------------RWKLVE-----KSNLEESDDPDGSQIE---KIKEEITQLRNNVFQE 658
                          + KL++     K+ LE+       Q++   K  ++I + ++   +E
Sbjct: 1059 AQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKE 1118

Query: 659  IYHEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELSS 718
            + +E+ +   +  +  +   E+  L+ E+   K  +   +  +   + LL  + + EL  
Sbjct: 1119 LVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKL-ELQG 1177

Query: 719  KRPLVRSEV-----NGQIILLKGYSVDVDTEAKVIERAATYHRAWREAE 762
            K   +++ V     N QI+  +    + + + + IE+ A  H   +E E
Sbjct: 1178 KADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKE 1226


>gi|208431829 eukaryotic translation initiation factor 2-alpha
           kinase 2 isoform b [Homo sapiens]
          Length = 510

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 49/166 (29%), Positives = 73/166 (43%), Gaps = 14/166 (8%)

Query: 809 LKVMKGVAQGLHTLHKADIIHGSLHQNNVFALNREQGIVGDFDFTKSVSQRASVNMMVGD 868
           L++ + + +G+  +H   +IH  L  +N+F ++ +Q  +GDF    S+          G 
Sbjct: 351 LELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGT 410

Query: 869 LSLMSPELKMGKPASPGSDLYAYGCLLL-WLSVQNQEFEINK------DGIPKVDQFHLD 921
           L  MSPE    +      DLYA G +L   L V +  FE +K      DGI   D F  D
Sbjct: 411 LRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIIS-DIF--D 467

Query: 922 DKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNPEKDTEYT 967
            K K+LL  L+    S   E   N    L        +PEK+  +T
Sbjct: 468 KKEKTLLQKLL----SKKPEDRPNTSEILRTLTVWKKSPEKNERHT 509


>gi|208431827 eukaryotic translation initiation factor 2-alpha
           kinase 2 isoform a [Homo sapiens]
          Length = 551

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 49/166 (29%), Positives = 73/166 (43%), Gaps = 14/166 (8%)

Query: 809 LKVMKGVAQGLHTLHKADIIHGSLHQNNVFALNREQGIVGDFDFTKSVSQRASVNMMVGD 868
           L++ + + +G+  +H   +IH  L  +N+F ++ +Q  +GDF    S+          G 
Sbjct: 392 LELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGT 451

Query: 869 LSLMSPELKMGKPASPGSDLYAYGCLLL-WLSVQNQEFEINK------DGIPKVDQFHLD 921
           L  MSPE    +      DLYA G +L   L V +  FE +K      DGI   D F  D
Sbjct: 452 LRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIIS-DIF--D 508

Query: 922 DKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNPEKDTEYT 967
            K K+LL  L+    S   E   N    L        +PEK+  +T
Sbjct: 509 KKEKTLLQKLL----SKKPEDRPNTSEILRTLTVWKKSPEKNERHT 550


>gi|4506103 eukaryotic translation initiation factor 2-alpha kinase
           2 isoform a [Homo sapiens]
          Length = 551

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 49/166 (29%), Positives = 73/166 (43%), Gaps = 14/166 (8%)

Query: 809 LKVMKGVAQGLHTLHKADIIHGSLHQNNVFALNREQGIVGDFDFTKSVSQRASVNMMVGD 868
           L++ + + +G+  +H   +IH  L  +N+F ++ +Q  +GDF    S+          G 
Sbjct: 392 LELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGT 451

Query: 869 LSLMSPELKMGKPASPGSDLYAYGCLLL-WLSVQNQEFEINK------DGIPKVDQFHLD 921
           L  MSPE    +      DLYA G +L   L V +  FE +K      DGI   D F  D
Sbjct: 452 LRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIIS-DIF--D 508

Query: 922 DKVKSLLCSLICYRSSMTAEQVLNAECFLMPKEQSVPNPEKDTEYT 967
            K K+LL  L+    S   E   N    L        +PEK+  +T
Sbjct: 509 KKEKTLLQKLL----SKKPEDRPNTSEILRTLTVWKKSPEKNERHT 550


>gi|110349799 testis-specific protein kinase 2 [Homo sapiens]
          Length = 571

 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 49/206 (23%), Positives = 88/206 (42%), Gaps = 18/206 (8%)

Query: 723 VRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFLCKSDPMA 782
           VR   +GQ++ LK  ++     A +++     +R        S    L F+ +C      
Sbjct: 75  VRHRASGQVMALKMNTLS-SNRANMLKEVQLMNRL-------SHPNILRFMGVCVHQGQL 126

Query: 783 YLMVPYYPRANLNAV-QANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFALN 841
           + +  Y    NL  +  +N+ L     +K+   +A GL  LH   I H  L   N     
Sbjct: 127 HALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKR 186

Query: 842 REQG---IVGDFDFTKS---VSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLL 895
            E G   +V DF   +    VS  +    +VG    M+PE+   +P +  +D+++YG +L
Sbjct: 187 DENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIIL 246

Query: 896 LWLSVQNQEFEINKDGIPKVDQFHLD 921
             +  +    + + D +P+ + F LD
Sbjct: 247 CEIIAR---IQADPDYLPRTENFGLD 269


>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
           sapiens]
          Length = 859

 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 31/129 (24%), Positives = 63/129 (48%), Gaps = 2/129 (1%)

Query: 770 LIFLFLCKSDPMAYLMVPYYPRANLNAV-QANMPLNSEETLKVMKGVAQGLHTLHKADII 828
           + F  +C   P   +++ +  +  L  V +A  P+     +    G+A G++ LH   II
Sbjct: 174 ITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKII 233

Query: 829 HGSLHQNNVFALNREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDL 888
           H  L   N+     +   + DF  +K +S +++     G ++ M+PE+   +P S   D+
Sbjct: 234 HRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDI 293

Query: 889 YAYGCLLLW 897
           +++G ++LW
Sbjct: 294 WSFG-VVLW 301


>gi|223671888 interleukin-1 receptor-associated kinase 4 isoform b
           [Homo sapiens]
          Length = 336

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 18/141 (12%)

Query: 784 LMVPYYPRANL----NAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFA 839
           L+  Y P  +L    + +    PL+     K+ +G A G++ LH+   IH  +   N+  
Sbjct: 136 LVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL 195

Query: 840 LNREQGIVGDFDFTKS---VSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLL 896
                  + DF   ++    +Q    + +VG  + M+PE   G+  +P SD+Y++G +LL
Sbjct: 196 DEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSFGVVLL 254

Query: 897 WLSVQNQEFEINKDGIPKVDQ 917
            +            G+P VD+
Sbjct: 255 EIIT----------GLPAVDE 265


>gi|223671885 interleukin-1 receptor-associated kinase 4 isoform b
           [Homo sapiens]
          Length = 336

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 18/141 (12%)

Query: 784 LMVPYYPRANL----NAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFA 839
           L+  Y P  +L    + +    PL+     K+ +G A G++ LH+   IH  +   N+  
Sbjct: 136 LVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL 195

Query: 840 LNREQGIVGDFDFTKS---VSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLL 896
                  + DF   ++    +Q    + +VG  + M+PE   G+  +P SD+Y++G +LL
Sbjct: 196 DEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSFGVVLL 254

Query: 897 WLSVQNQEFEINKDGIPKVDQ 917
            +            G+P VD+
Sbjct: 255 EIIT----------GLPAVDE 265


>gi|223671883 interleukin-1 receptor-associated kinase 4 isoform b
           [Homo sapiens]
          Length = 336

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 18/141 (12%)

Query: 784 LMVPYYPRANL----NAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFA 839
           L+  Y P  +L    + +    PL+     K+ +G A G++ LH+   IH  +   N+  
Sbjct: 136 LVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL 195

Query: 840 LNREQGIVGDFDFTKS---VSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLL 896
                  + DF   ++    +Q    + +VG  + M+PE   G+  +P SD+Y++G +LL
Sbjct: 196 DEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSFGVVLL 254

Query: 897 WLSVQNQEFEINKDGIPKVDQ 917
            +            G+P VD+
Sbjct: 255 EIIT----------GLPAVDE 265


>gi|166795293 interleukin-1 receptor-associated kinase 4 isoform a
           [Homo sapiens]
          Length = 460

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 18/141 (12%)

Query: 784 LMVPYYPRANL----NAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFA 839
           L+  Y P  +L    + +    PL+     K+ +G A G++ LH+   IH  +   N+  
Sbjct: 260 LVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL 319

Query: 840 LNREQGIVGDFDFTKS---VSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLL 896
                  + DF   ++    +Q    + +VG  + M+PE   G+  +P SD+Y++G +LL
Sbjct: 320 DEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSFGVVLL 378

Query: 897 WLSVQNQEFEINKDGIPKVDQ 917
            +            G+P VD+
Sbjct: 379 EIIT----------GLPAVDE 389


>gi|166795295 interleukin-1 receptor-associated kinase 4 isoform a
           [Homo sapiens]
          Length = 460

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 18/141 (12%)

Query: 784 LMVPYYPRANL----NAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFA 839
           L+  Y P  +L    + +    PL+     K+ +G A G++ LH+   IH  +   N+  
Sbjct: 260 LVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL 319

Query: 840 LNREQGIVGDFDFTKS---VSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLL 896
                  + DF   ++    +Q    + +VG  + M+PE   G+  +P SD+Y++G +LL
Sbjct: 320 DEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSFGVVLL 378

Query: 897 WLSVQNQEFEINKDGIPKVDQ 917
            +            G+P VD+
Sbjct: 379 EIIT----------GLPAVDE 389


>gi|4758650 kinesin family member 5C [Homo sapiens]
          Length = 957

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 100/483 (20%), Positives = 198/483 (40%), Gaps = 61/483 (12%)

Query: 242 LDLKDE--NDAGNLITFPKESLAVGDFNLGSNV-SLEKIKQDQKLIE-ENEKLKTEKDAL 297
           LD KD+  N    L    K+ +   D  L S     EKI+++   ++ ENE  K E   +
Sbjct: 428 LDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEV 487

Query: 298 LESYKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEIL--KEMR 355
           L++ + L +  +Q +QE++ +  A   LT+ L     T + T  + L+   E+   ++ R
Sbjct: 488 LQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTT-LTTTQRELSQLQELSNHQKKR 546

Query: 356 HVDISVRFGKDLSDAIQVLDEGCFTTPASLNGL---EIIWAEYSLAQENIKTCEYVSEGN 412
             +I     KDL +   ++      T A +NG+   E   A   +++   +    V+   
Sbjct: 547 ATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSK 606

Query: 413 ILIAQRNEMQQKLYMSVEDF-ILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGAN--SD 469
            L + + +  +K+  S  +    ++  S    ++K+L D   ++E    Q +E  +  S+
Sbjct: 607 QLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSE 666

Query: 470 EILK----------KFYD--------------WKCDKREEFTSVRSETDASLHRLVAWFQ 505
           E+ K           F D               K    ++  S R      L RL    +
Sbjct: 667 ELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQLSRLRDEIE 726

Query: 506 RTLKVF----DLSVEGSLISEDAMDNIDEI-LEKTESSVCKELEIALVD---QGDADKEI 557
              K+     DL+ +  L  E    + +++ +E  E  +  E  + L D   Q   D + 
Sbjct: 727 EKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLLNDKREQAREDLKG 786

Query: 558 ISNTYSQVLQKIHSEERL-IATVQAKYKDSIEF----------KKQLIEYLNKSPSVDHL 606
           +  T S+ LQ +H+  +L +  +  + K S+E           +KQ I +L    +++ L
Sbjct: 787 LEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLEN--NLEQL 844

Query: 607 LSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIYHEREEY 666
             + K L    A LR +L     LE+       +++ ++  + + + N  ++    ++E 
Sbjct: 845 TKVHKQLVRDNADLRCEL---PKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEV 901

Query: 667 EML 669
           + +
Sbjct: 902 DRI 904


>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
          Length = 841

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 40/154 (25%), Positives = 61/154 (39%), Gaps = 15/154 (9%)

Query: 753 TYHRAWREAEGDSGLLPLIFLFLCKSDPMAYLMVPYYPRANLNAVQANMPLNSEETLKVM 812
           TY  +W   EG  GLL ++  F    D    L             Q    L   + ++  
Sbjct: 67  TYKESW---EGGDGLLYIVMGFCEGGDLYRKLKE-----------QKGQLLPENQVVEWF 112

Query: 813 KGVAQGLHTLHKADIIHGSLHQNNVFALNREQGIVGDFDFTKSVSQRASV-NMMVGDLSL 871
             +A  L  LH+  I+H  L   NVF        VGD    + +     + + ++G    
Sbjct: 113 VQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYY 172

Query: 872 MSPELKMGKPASPGSDLYAYGCLLLWLSVQNQEF 905
           MSPEL   KP +  SD++A GC +  ++     F
Sbjct: 173 MSPELFSNKPYNYKSDVWALGCCVYEMATLKHAF 206


>gi|66932999 testis-specific protein kinase 1 [Homo sapiens]
          Length = 626

 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 38/161 (23%), Positives = 69/161 (42%), Gaps = 12/161 (7%)

Query: 770 LIFLFLCKSDPMAYLMVPYYPRANLNAVQANM-PLNSEETLKVMKGVAQGLHTLHKADII 828
           L F+ +C      + +  Y     L  + ++  PL+    L +   +A+GL  LH   + 
Sbjct: 113 LRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVF 172

Query: 829 HGSLHQNNVFALNREQG---IVGDFDFTKSV-----SQRASVNMMVGDLSLMSPELKMGK 880
           H  L   N      ++G   +VGDF   + +       R     +VG    M+PE+  G+
Sbjct: 173 HRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGE 232

Query: 881 PASPGSDLYAYGCLLLWLSVQNQEFEINKDGIPKVDQFHLD 921
                +D++A+G +L  L  +      + D +P+ + F LD
Sbjct: 233 LYDEKADVFAFGIVLCELIAR---VPADPDYLPRTEDFGLD 270


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 91/427 (21%), Positives = 182/427 (42%), Gaps = 50/427 (11%)

Query: 278  KQDQKLIEENEKLKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYI 337
            KQ + L EE E LKTE +  L++  A +    +  QE+ + K A  + T + E  ++   
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQ--- 1195

Query: 338  DTRMKNLAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSL 397
            D R ++  A  E+ +++     + RF  +L    Q L+         +  L+ + AE   
Sbjct: 1196 DMRQRHATALEELSEQLEQ---AKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEH 1252

Query: 398  AQENI-----KTCEYVSEGNILIAQRNEMQQKLYMSVEDF--ILE----------VDESS 440
             ++ +     +    VSEG+ L  +  E   KL   +++   +LE           D +S
Sbjct: 1253 KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAAS 1312

Query: 441  LNKRLKTLQDL-------SVSLEAVYGQAKEGANS--------DEILKKFYDWKCDKREE 485
            L  +L+  Q+L        ++L +   Q +E  NS        +E  K         + +
Sbjct: 1313 LESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQ 1372

Query: 486  FTSVRSETDASLHRLVAWFQRTLKVF-DLSVEGSLISEDAMDNIDEILEKTESSVCKELE 544
                + + D  L  + +  +   K+  D       + E A+    + LEKT++ + +EL+
Sbjct: 1373 LADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKAL--AYDKLEKTKNRLQQELD 1430

Query: 545  IALVDQGDADKEIISN--TYSQVLQKIHSEERLIATVQAKYKD--SIEFKKQLIEYLNKS 600
               VD  D  +++ SN     +   ++ +EE+ I+   A+ +D    E +++  + L+ +
Sbjct: 1431 DLTVDL-DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLA 1489

Query: 601  PSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIY 660
             +++  L  K+  +     LR    +  +L  S D  G  + ++++    L   V +E+ 
Sbjct: 1490 RALEEALEAKEEFERQNKQLR---ADMEDLMSSKDDVGKNVHELEKSKRALEQQV-EEMR 1545

Query: 661  HEREEYE 667
             + EE E
Sbjct: 1546 TQLEELE 1552



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 89/420 (21%), Positives = 179/420 (42%), Gaps = 57/420 (13%)

Query: 272  VSLEKIKQDQKLIEENEK---LKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLT-- 326
            + LEK+  + K+ +  E+   L+ +    ++  K +E ++ + + +L +E+  A +L   
Sbjct: 969  LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKI 1028

Query: 327  -NHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASL 385
             N  E  +    +   K    + E+ K  R +D       DL D I  L        A +
Sbjct: 1029 RNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT---DLQDQIAELQ-------AQI 1078

Query: 386  NGLEIIWAEY------SLAQENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVDES 439
            + L++  A+       +LA+ + +T   + + N L   R E+Q ++    EDF  E +++
Sbjct: 1079 DELKLQLAKKEEELQGALARGDDET---LHKNNALKVVR-ELQAQIAELQEDF--ESEKA 1132

Query: 440  SLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKCDKREEFTSVRSETDASLHR 499
            S NK  K  +DLS  LEA+  + ++  ++    ++    +  + +E   ++   +     
Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQEL---RTKREQEVAELKKALEEETKN 1189

Query: 500  LVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSV---CKEL--EIALVDQGDAD 554
              A  Q   +    ++E      +        LEK +  +    KEL  E+ ++ Q  A+
Sbjct: 1190 HEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAE 1249

Query: 555  KEIISNTYSQVLQKIHSE----ERL---IATVQAKYKDSIEFKKQLIEYLNKS--PSVDH 605
             E         +Q++H++    +RL   +A   +K ++ ++    L+E   K        
Sbjct: 1250 SEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKD 1309

Query: 606  LLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEIYHEREE 665
              S++  L+  + LL+ +  +K NL        S+I +++EE      N  QE   E EE
Sbjct: 1310 AASLESQLQDTQELLQEETRQKLNL-------SSRIRQLEEE-----KNSLQEQQEEEEE 1357



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 49/207 (23%), Positives = 94/207 (45%), Gaps = 13/207 (6%)

Query: 278  KQDQKLIEENEKLKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYI 337
            ++  +L +E     + K ALL+  + LE ++ Q+ +EL++E+ + ++L N         +
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ-SNMELLNDRFRKTTLQV 1766

Query: 338  DTRMKNLAAKMEILKEMRHVDISV-RFGKDLSDAIQVLDEGCFTT--PASLNGLE--IIW 392
            DT    LAA+    ++  +    + R  K+L   +Q L EG   +   A+++ LE  I  
Sbjct: 1767 DTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQEL-EGAVKSKFKATISALEAKIGQ 1825

Query: 393  AEYSLAQENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVDE--SSLNKRLKTLQD 450
             E  L QE     +  +  N L+ +  +  ++++M VED     D+    + K    ++ 
Sbjct: 1826 LEEQLEQE----AKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQ 1881

Query: 451  LSVSLEAVYGQAKEGANSDEILKKFYD 477
            L   LE    +A     S   L++  D
Sbjct: 1882 LKRQLEEAEEEATRANASRRKLQRELD 1908


>gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform 1
           [Homo sapiens]
          Length = 556

 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 32/88 (36%), Positives = 43/88 (48%), Gaps = 5/88 (5%)

Query: 815 VAQGLHTLHKADIIHGSLHQNNVFALNREQGI-VGDFDFTKSVS---QRASVNMMVGDLS 870
           +   L  LH   IIH  L   N+  LN +  I + DF   K +S   ++A  N  VG   
Sbjct: 189 IVSALEYLHGKGIIHRDLKPENIL-LNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQ 247

Query: 871 LMSPELKMGKPASPGSDLYAYGCLLLWL 898
            +SPEL   K A   SDL+A GC++  L
Sbjct: 248 YVSPELLTEKSACKSSDLWALGCIIYQL 275


>gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent
           protein kinase-1 [Homo sapiens]
          Length = 471

 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 32/88 (36%), Positives = 43/88 (48%), Gaps = 5/88 (5%)

Query: 815 VAQGLHTLHKADIIHGSLHQNNVFALNREQGI-VGDFDFTKSVS---QRASVNMMVGDLS 870
           +   L  LH   IIH  L   N+  LN +  I + DF   K +S   ++A  N  VG   
Sbjct: 208 IVSALEYLHGKGIIHRDLKPENIL-LNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQ 266

Query: 871 LMSPELKMGKPASPGSDLYAYGCLLLWL 898
            +SPEL   K A   SDL+A GC++  L
Sbjct: 267 YVSPELLTEKSACKSSDLWALGCIIYQL 294


>gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo
           sapiens]
          Length = 396

 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 32/88 (36%), Positives = 43/88 (48%), Gaps = 5/88 (5%)

Query: 815 VAQGLHTLHKADIIHGSLHQNNVFALNREQGI-VGDFDFTKSVS---QRASVNMMVGDLS 870
           +   L  LH   IIH  L   N+  LN +  I + DF   K +S   ++A  N  VG   
Sbjct: 162 IVSALEYLHGKGIIHRDLKPENIL-LNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQ 220

Query: 871 LMSPELKMGKPASPGSDLYAYGCLLLWL 898
            +SPEL   K A   SDL+A GC++  L
Sbjct: 221 YVSPELLTEKSACKSSDLWALGCIIYQL 248


>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
          Length = 1030

 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 38/146 (26%), Positives = 66/146 (45%), Gaps = 9/146 (6%)

Query: 783 YLMVPYYPRANLNAVQANMP--LNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL 840
           YL+  Y  +  L  ++  MP  +  E+    +  + + +H  HK DI+H  +   N+   
Sbjct: 86  YLVFEYVEKNMLELLE-EMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLIS 144

Query: 841 NREQGIVGDFDFTKSVSQ--RASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWL 898
           + +   + DF F +++S+   A+    V      SPEL +G P     D+++ GC+L  L
Sbjct: 145 HNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGEL 204

Query: 899 SVQNQEFEINKDGIPKVDQFHLDDKV 924
           S     F     G  ++DQ     KV
Sbjct: 205 SDGQPLF----PGESEIDQLFTIQKV 226


>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
          Length = 1030

 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 38/146 (26%), Positives = 66/146 (45%), Gaps = 9/146 (6%)

Query: 783 YLMVPYYPRANLNAVQANMP--LNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFAL 840
           YL+  Y  +  L  ++  MP  +  E+    +  + + +H  HK DI+H  +   N+   
Sbjct: 86  YLVFEYVEKNMLELLE-EMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLIS 144

Query: 841 NREQGIVGDFDFTKSVSQ--RASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGCLLLWL 898
           + +   + DF F +++S+   A+    V      SPEL +G P     D+++ GC+L  L
Sbjct: 145 HNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGEL 204

Query: 899 SVQNQEFEINKDGIPKVDQFHLDDKV 924
           S     F     G  ++DQ     KV
Sbjct: 205 SDGQPLF----PGESEIDQLFTIQKV 226


>gi|118498362 kinectin 1 isoform b [Homo sapiens]
          Length = 1306

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 83/403 (20%), Positives = 167/403 (41%), Gaps = 66/403 (16%)

Query: 274 LEKIKQDQKLIEENEKLKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTNHLEYTL 333
           ++ ++ +QK + + E L+ +   +LE  +AL+ +++Q   ++  + +A+V     L   L
Sbjct: 551 MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV-----LAEEL 605

Query: 334 KTYIDTRMKNLAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWA 393
              I  + K +    + L   R  D      ++L D IQ ++   F   A +  L+ +  
Sbjct: 606 HKVIAEKDKQIKQTEDSLASER--DRLTSKEEELKD-IQNMN---FLLKAEVQKLQALAN 659

Query: 394 EYSLAQ---ENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDF-ILEVDESSLNKRLKTLQ 449
           E + A    E ++   YV +  I + +  ++Q ++   +E+F IL     +L   ++ LQ
Sbjct: 660 EQAAAAHELEKMQQSVYVKDDKIRLLE-EQLQHEISNKMEEFKILNDQNKALKSEVQKLQ 718

Query: 450 DLSVSLEAVYGQAKEGANSDEILKKFYDWKCDKREEFTSVRSETDASLHRLVAWFQRTLK 509
            L            E  N D +            E+      E D             LK
Sbjct: 719 TL----------VSEQPNKDVV------------EQMEKCIQEKD-----------EKLK 745

Query: 510 VFDLSVEGSLISEDAMDNIDEILEKTESSVCKELEIALVDQGDADKEIISNTYSQVLQKI 569
             +  +E  LI     +     +    SS+ KE++     Q   D+   ++   ++ + I
Sbjct: 746 TVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQN--DQVSFASLVEELKKVI 803

Query: 570 HSEERLIATVQAKYKDSIEFKKQLIEYLNKSPSVDHLLSIKKTLKSLKALLRWKLVE--- 626
           H ++  I +V+         + +L++  NK  +V   LSI   ++ L+ LL+ K  +   
Sbjct: 804 HEKDGKIKSVEEL------LEAELLKVANKEKTVQ--LSITSKVQELQNLLKGKEEQMNT 855

Query: 627 -KSNLEESDDP---DGSQIEKIKEEITQLRNNVFQEIYHEREE 665
            K+ LEE +      G  ++ ++EE   L+ +V +   H  +E
Sbjct: 856 MKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKE 898


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,994,114
Number of Sequences: 37866
Number of extensions: 1521383
Number of successful extensions: 5889
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 101
Number of HSP's successfully gapped in prelim test: 501
Number of HSP's that attempted gapping in prelim test: 5131
Number of HSP's gapped (non-prelim): 1172
length of query: 996
length of database: 18,247,518
effective HSP length: 112
effective length of query: 884
effective length of database: 14,006,526
effective search space: 12381768984
effective search space used: 12381768984
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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