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Search of human proteins with 170295797
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|170295797 carbamoyl-phosphate synthetase 1 isoform c [Homo
sapiens]
(1049 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|170295797 carbamoyl-phosphate synthetase 1 isoform c [Homo sa... 2081 0.0
gi|169790915 carbamoyl-phosphate synthetase 1 isoform a precurso... 2081 0.0
gi|21361331 carbamoyl-phosphate synthetase 1 isoform b precursor... 2081 0.0
gi|18105007 carbamoylphosphate synthetase 2/aspartate transcarba... 1045 0.0
gi|38679977 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo ... 65 3e-10
gi|38679974 acetyl-Coenzyme A carboxylase alpha isoform 4 [Homo ... 65 3e-10
gi|38679971 acetyl-Coenzyme A carboxylase alpha isoform 3 [Homo ... 65 3e-10
gi|38679967 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo ... 65 3e-10
gi|38679960 acetyl-Coenzyme A carboxylase alpha isoform 1 [Homo ... 65 3e-10
gi|116805327 methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) pr... 62 2e-09
gi|106049528 pyruvate carboxylase precursor [Homo sapiens] 56 2e-07
gi|106049295 pyruvate carboxylase precursor [Homo sapiens] 56 2e-07
gi|106049292 pyruvate carboxylase precursor [Homo sapiens] 56 2e-07
gi|65506442 propionyl-Coenzyme A carboxylase, alpha polypeptide ... 54 6e-07
gi|189095269 propionyl-Coenzyme A carboxylase, alpha polypeptide... 54 6e-07
gi|134142062 acetyl-Coenzyme A carboxylase beta [Homo sapiens] 54 8e-07
gi|28416899 phosphoribosylglycinamide formyltransferase, phospho... 38 0.057
gi|4503915 phosphoribosylglycinamide formyltransferase, phosphor... 38 0.057
gi|209869995 phosphoribosylglycinamide formyltransferase, phosph... 38 0.057
gi|209869993 phosphoribosylglycinamide formyltransferase, phosph... 38 0.057
gi|148839342 ATP-grasp domain containing 1 [Homo sapiens] 35 0.37
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 33 1.8
gi|24308398 transmembrane protein 116 [Homo sapiens] 32 3.1
gi|110611228 utrophin [Homo sapiens] 31 7.0
gi|154759423 Cdk5 and Abl enzyme substrate 1 isoform 2 [Homo sap... 30 9.1
gi|24308408 Cdk5 and Abl enzyme substrate 1 isoform 1 [Homo sapi... 30 9.1
>gi|170295797 carbamoyl-phosphate synthetase 1 isoform c [Homo
sapiens]
Length = 1049
Score = 2081 bits (5392), Expect = 0.0
Identities = 1049/1049 (100%), Positives = 1049/1049 (100%)
Query: 1 MKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQ 60
MKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQ
Sbjct: 1 MKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQ 60
Query: 61 TALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIE 120
TALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIE
Sbjct: 61 TALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIE 120
Query: 121 DALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKE 180
DALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKE
Sbjct: 121 DALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKE 180
Query: 181 IEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHL 240
IEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHL
Sbjct: 181 IEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHL 240
Query: 241 GIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIK 300
GIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIK
Sbjct: 241 GIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIK 300
Query: 301 NVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQK 360
NVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQK
Sbjct: 301 NVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQK 360
Query: 361 ALRMCHPSIEGFTPRLPMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLT 420
ALRMCHPSIEGFTPRLPMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLT
Sbjct: 361 ALRMCHPSIEGFTPRLPMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLT 420
Query: 421 YIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTREL 480
YIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTREL
Sbjct: 421 YIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTREL 480
Query: 481 RLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVE 540
RLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVE
Sbjct: 481 RLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVE 540
Query: 541 FDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGG 600
FDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGG
Sbjct: 541 FDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGG 600
Query: 601 CIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNT 660
CIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNT
Sbjct: 601 CIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNT 660
Query: 661 LNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVE 720
LNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVE
Sbjct: 661 LNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVE 720
Query: 721 GAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIA 780
GAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIA
Sbjct: 721 GAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIA 780
Query: 781 KAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEK 840
KAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEK
Sbjct: 781 KAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEK 840
Query: 841 HLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAML 900
HLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAML
Sbjct: 841 HLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAML 900
Query: 901 STGFKIPQKGILIGIQQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWP 960
STGFKIPQKGILIGIQQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWP
Sbjct: 901 STGFKIPQKGILIGIQQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWP 960
Query: 961 SQEGQNPSLSSIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTK 1020
SQEGQNPSLSSIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTK
Sbjct: 961 SQEGQNPSLSSIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTK 1020
Query: 1021 LFAEAVQKSRKVDSKSLFHYRQYSAGKAA 1049
LFAEAVQKSRKVDSKSLFHYRQYSAGKAA
Sbjct: 1021 LFAEAVQKSRKVDSKSLFHYRQYSAGKAA 1049
>gi|169790915 carbamoyl-phosphate synthetase 1 isoform a precursor
[Homo sapiens]
Length = 1506
Score = 2081 bits (5392), Expect = 0.0
Identities = 1049/1049 (100%), Positives = 1049/1049 (100%)
Query: 1 MKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQ 60
MKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQ
Sbjct: 458 MKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQ 517
Query: 61 TALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIE 120
TALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIE
Sbjct: 518 TALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIE 577
Query: 121 DALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKE 180
DALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKE
Sbjct: 578 DALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKE 637
Query: 181 IEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHL 240
IEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHL
Sbjct: 638 IEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHL 697
Query: 241 GIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIK 300
GIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIK
Sbjct: 698 GIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIK 757
Query: 301 NVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQK 360
NVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQK
Sbjct: 758 NVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQK 817
Query: 361 ALRMCHPSIEGFTPRLPMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLT 420
ALRMCHPSIEGFTPRLPMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLT
Sbjct: 818 ALRMCHPSIEGFTPRLPMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLT 877
Query: 421 YIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTREL 480
YIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTREL
Sbjct: 878 YIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTREL 937
Query: 481 RLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVE 540
RLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVE
Sbjct: 938 RLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVE 997
Query: 541 FDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGG 600
FDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGG
Sbjct: 998 FDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGG 1057
Query: 601 CIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNT 660
CIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNT
Sbjct: 1058 CIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNT 1117
Query: 661 LNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVE 720
LNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVE
Sbjct: 1118 LNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVE 1177
Query: 721 GAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIA 780
GAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIA
Sbjct: 1178 GAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIA 1237
Query: 781 KAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEK 840
KAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEK
Sbjct: 1238 KAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEK 1297
Query: 841 HLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAML 900
HLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAML
Sbjct: 1298 HLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAML 1357
Query: 901 STGFKIPQKGILIGIQQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWP 960
STGFKIPQKGILIGIQQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWP
Sbjct: 1358 STGFKIPQKGILIGIQQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWP 1417
Query: 961 SQEGQNPSLSSIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTK 1020
SQEGQNPSLSSIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTK
Sbjct: 1418 SQEGQNPSLSSIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTK 1477
Query: 1021 LFAEAVQKSRKVDSKSLFHYRQYSAGKAA 1049
LFAEAVQKSRKVDSKSLFHYRQYSAGKAA
Sbjct: 1478 LFAEAVQKSRKVDSKSLFHYRQYSAGKAA 1506
Score = 167 bits (422), Expect = 6e-41
Identities = 109/393 (27%), Positives = 192/393 (48%), Gaps = 22/393 (5%)
Query: 525 MMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTD---FDECDKLYF 581
+++LG G IG + EFD+ +++ +++ KTV++N N +V T+ + D +YF
Sbjct: 431 VLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYF 490
Query: 582 EELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKN------GVKIMGTSPLQIDRA 635
++ + + ++ E G I+ +GGQ N V L+K GVK++GTS I
Sbjct: 491 LPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMAT 550
Query: 636 EDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSED 695
EDR +FS L+E+ AP AV ++ +AL+ A ++ YP ++R +Y L G + + +
Sbjct: 551 EDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRE 610
Query: 696 EMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAV-GKDGRVISHAISEHVEDAGVHSGD 754
+ +A ++ + +++ K V G +E+E + V D ++ E+V+ GVH+GD
Sbjct: 611 TLMDLSTKAFAMTNQ--ILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGD 668
Query: 755 ATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLV--KGNDVLVIECNLRASRS 812
+ ++ P QT+S + ++ + + + I G N+QF + + +IE N R SRS
Sbjct: 669 SVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRS 728
Query: 813 FPFVSKTLGVDFIDVATKVMIG------ENVDEKHLPTLDHPIIPADYVAIKAPMFSWPR 866
SK G +A K+ +G +NV P + DY+ K P + R
Sbjct: 729 SALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSL--DYMVTKIPRWDLDR 786
Query: 867 LRDADPILRCEMASTGEVACFGEGIHTAFLKAM 899
+ M S GEV G +F KA+
Sbjct: 787 FHGTSSRIGSSMKSVGEVMAIGRTFEESFQKAL 819
>gi|21361331 carbamoyl-phosphate synthetase 1 isoform b precursor
[Homo sapiens]
Length = 1500
Score = 2081 bits (5392), Expect = 0.0
Identities = 1049/1049 (100%), Positives = 1049/1049 (100%)
Query: 1 MKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQ 60
MKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQ
Sbjct: 452 MKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQ 511
Query: 61 TALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIE 120
TALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIE
Sbjct: 512 TALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIE 571
Query: 121 DALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKE 180
DALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKE
Sbjct: 572 DALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKE 631
Query: 181 IEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHL 240
IEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHL
Sbjct: 632 IEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHL 691
Query: 241 GIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIK 300
GIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIK
Sbjct: 692 GIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIK 751
Query: 301 NVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQK 360
NVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQK
Sbjct: 752 NVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQK 811
Query: 361 ALRMCHPSIEGFTPRLPMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLT 420
ALRMCHPSIEGFTPRLPMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLT
Sbjct: 812 ALRMCHPSIEGFTPRLPMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLT 871
Query: 421 YIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTREL 480
YIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTREL
Sbjct: 872 YIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTREL 931
Query: 481 RLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVE 540
RLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVE
Sbjct: 932 RLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVE 991
Query: 541 FDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGG 600
FDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGG
Sbjct: 992 FDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGG 1051
Query: 601 CIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNT 660
CIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNT
Sbjct: 1052 CIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNT 1111
Query: 661 LNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVE 720
LNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVE
Sbjct: 1112 LNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVE 1171
Query: 721 GAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIA 780
GAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIA
Sbjct: 1172 GAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIA 1231
Query: 781 KAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEK 840
KAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEK
Sbjct: 1232 KAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEK 1291
Query: 841 HLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAML 900
HLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAML
Sbjct: 1292 HLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAML 1351
Query: 901 STGFKIPQKGILIGIQQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWP 960
STGFKIPQKGILIGIQQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWP
Sbjct: 1352 STGFKIPQKGILIGIQQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWP 1411
Query: 961 SQEGQNPSLSSIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTK 1020
SQEGQNPSLSSIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTK
Sbjct: 1412 SQEGQNPSLSSIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTK 1471
Query: 1021 LFAEAVQKSRKVDSKSLFHYRQYSAGKAA 1049
LFAEAVQKSRKVDSKSLFHYRQYSAGKAA
Sbjct: 1472 LFAEAVQKSRKVDSKSLFHYRQYSAGKAA 1500
Score = 167 bits (422), Expect = 6e-41
Identities = 109/393 (27%), Positives = 192/393 (48%), Gaps = 22/393 (5%)
Query: 525 MMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTD---FDECDKLYF 581
+++LG G IG + EFD+ +++ +++ KTV++N N +V T+ + D +YF
Sbjct: 425 VLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYF 484
Query: 582 EELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKN------GVKIMGTSPLQIDRA 635
++ + + ++ E G I+ +GGQ N V L+K GVK++GTS I
Sbjct: 485 LPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMAT 544
Query: 636 EDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSED 695
EDR +FS L+E+ AP AV ++ +AL+ A ++ YP ++R +Y L G + + +
Sbjct: 545 EDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRE 604
Query: 696 EMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAV-GKDGRVISHAISEHVEDAGVHSGD 754
+ +A ++ + +++ K V G +E+E + V D ++ E+V+ GVH+GD
Sbjct: 605 TLMDLSTKAFAMTNQ--ILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGD 662
Query: 755 ATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLV--KGNDVLVIECNLRASRS 812
+ ++ P QT+S + ++ + + + I G N+QF + + +IE N R SRS
Sbjct: 663 SVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRS 722
Query: 813 FPFVSKTLGVDFIDVATKVMIG------ENVDEKHLPTLDHPIIPADYVAIKAPMFSWPR 866
SK G +A K+ +G +NV P + DY+ K P + R
Sbjct: 723 SALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSL--DYMVTKIPRWDLDR 780
Query: 867 LRDADPILRCEMASTGEVACFGEGIHTAFLKAM 899
+ M S GEV G +F KA+
Sbjct: 781 FHGTSSRIGSSMKSVGEVMAIGRTFEESFQKAL 813
>gi|18105007 carbamoylphosphate synthetase 2/aspartate
transcarbamylase/dihydroorotase [Homo sapiens]
Length = 2225
Score = 1045 bits (2703), Expect = 0.0
Identities = 544/1036 (52%), Positives = 741/1036 (71%), Gaps = 28/1036 (2%)
Query: 1 MKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQ 60
+KEEN++T+L+NPNIA+VQT++ GL AD VYFLPITP +VT+VI+ E+PDG++L GGQ
Sbjct: 423 LKEENIQTLLINPNIATVQTSQ-GL--ADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQ 479
Query: 61 TALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIE 120
TALNCGVEL K GVL YGV+VLGT VE+I TEDR+ F+ ++ EI E +APS A S+E
Sbjct: 480 TALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLE 539
Query: 121 DALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKE 180
A AA+ +GYPV++R+A+ALGGLGSG NRE L L AFA T+Q+LV+KS+ GWKE
Sbjct: 540 QAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKE 599
Query: 181 IEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHL 240
IEYEVVRDA NCVTVCNMEN+D +G+HTG+S+VVAP+QTL++ E+Q+LR+T+I V +HL
Sbjct: 600 IEYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTLNDREYQLLRQTAIKVTQHL 659
Query: 241 GIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIK 300
GIVGECN+Q+AL+P S +Y IIEVNARLSRSSALASKATGYPLA++AAK+ALGIPLPE++
Sbjct: 660 GIVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELR 719
Query: 301 NVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQK 360
N V+G T+A FEPS+DY V KIPRWDL +F S++IGS MKSVGEVM IGR+FEE+FQK
Sbjct: 720 NSVTGGTAA-FEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQK 778
Query: 361 ALRMCHPSIEGFTPRLPMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLT 420
ALRM + GF + + EL P+ RI+ +A A+ S+D + +LT
Sbjct: 779 ALRMVDENCVGFDHTVKPVSDM--------ELETPTDKRIFVVAAALWAGYSVDRLYELT 830
Query: 421 YIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTREL 480
ID+WFL++M+ I+ + L+ + + + L++AK +GFSDKQI+ + TE R+L
Sbjct: 831 RIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKL 890
Query: 481 RLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVE 540
R + I P VKQIDT+AAE+P+ TNYLY+TY G HD+ F ++VLG G Y IGSSVE
Sbjct: 891 RQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVE 950
Query: 541 FDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGG 600
FDWCAV I+ LR++G KT++VN NPETVSTD+D CD+LYF+E+S E ++DIY E G
Sbjct: 951 FDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEG 1010
Query: 601 CIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNT 660
I+S+GGQ+PNN+A+ L++ +++GTSP ID AE+R FS +LD + ++Q W+ ++
Sbjct: 1011 VILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSD 1070
Query: 661 LNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVE 720
L A +F ++V YPC++RPSYVLSG+AMNV +++ ++++FL A VS+EHPVV++KF++
Sbjct: 1071 LESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQ 1130
Query: 721 GAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIA 780
A+E+++DAV DG V + AISEHVE+AGVHSGDATL+ P Q I+ +E++K +
Sbjct: 1131 EAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVG 1190
Query: 781 KAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEK 840
+ ++GPFN+Q + K + + VIECN+R SRSFPFVSKTLGVD + +AT+V++GE V+
Sbjct: 1191 QELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPV 1250
Query: 841 HLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAML 900
L T + V +K P FS+ RL AD +L EM STGEVA FGE A+LKAML
Sbjct: 1251 GLMT------GSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAML 1304
Query: 901 STGFKIPQKGILIGI-QQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAW 959
STGFKIP+K IL+ I + L L + G+ L+A+ T+D+ + V T V W
Sbjct: 1305 STGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDW 1364
Query: 960 PSQE---GQNPSLSSIRKLIRDGSIDLVINLPNNN------TKFVHDNYVIRRTAVDSGI 1010
+E G+ P SI + + + + +LVINL + FV Y RR A D +
Sbjct: 1365 HFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSV 1424
Query: 1011 PLLTNFQVTKLFAEAV 1026
PL+ + + TKLF EA+
Sbjct: 1425 PLIIDIKCTKLFVEAL 1440
Score = 154 bits (388), Expect = 5e-37
Identities = 110/393 (27%), Positives = 190/393 (48%), Gaps = 26/393 (6%)
Query: 525 MMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEEL 584
+++LG G IG + EFD+ +I+ L++ +T+++N N TV T DK+YF +
Sbjct: 396 VLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQGLADKVYFLPI 455
Query: 585 SLERILDIYHQEACGGCIISVGGQIPNNLAVPLYK------NGVKIMGTSPLQIDRAEDR 638
+ + + E G +++ GGQ N V L K GV+++GT I+ EDR
Sbjct: 456 TPHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDR 515
Query: 639 SIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMK 698
F+A + E+ AP +A N+L +A A+ + YP L+R ++ L G + +E+
Sbjct: 516 RAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELS 575
Query: 699 KFLEEATRVSQEHPVVLTKFVEGAREVEMDAV-GKDGRVISHAISEHVEDAGVHSGDATL 757
+ A + V++ K ++G +E+E + V G ++ E+++ G+H+G++ +
Sbjct: 576 ALV--APAFAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPLGIHTGESIV 633
Query: 758 MLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLV--KGNDVLVIECNLRASRSFPF 815
+ P+QT++ + ++ K+ + I G NVQ+ + + +IE N R SRS
Sbjct: 634 VAPSQTLNDREYQLLRQTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRSSAL 693
Query: 816 VSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPII--------PADYVAIKAPMFSWPR- 866
SK G VA K+ +G LP L + + DY +K P + +
Sbjct: 694 ASKATGYPLAYVAAKLALG-----IPLPELRNSVTGGTAAFEPSVDYCVVKIPRWDLSKF 748
Query: 867 LRDADPILRCEMASTGEVACFGEGIHTAFLKAM 899
LR + I C M S GEV G AF KA+
Sbjct: 749 LRVSTKIGSC-MKSVGEVMGIGRSFEEAFQKAL 780
>gi|38679977 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo
sapiens]
Length = 2346
Score = 65.1 bits (157), Expect = 3e-10
Identities = 53/252 (21%), Positives = 110/252 (43%), Gaps = 9/252 (3%)
Query: 55 LGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSF 114
+G Q G ++ V + G+ L S + FS ++ + +++
Sbjct: 230 MGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKG 289
Query: 115 AVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDL--STKAFAMTNQILVE 172
V+ ++D L+AA+ +GYPVMI+++ GG G N + +L +A + I V
Sbjct: 290 YVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVM 349
Query: 173 KSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVV--APAQTLSNAEFQMLR 230
+ + +E +++ D N +++ + V ++ APA + A F+ +
Sbjct: 350 RLAKQSRHLEVQILADQYGNAISLFGRD----CSVQRRHQKIIEEAPATIATPAVFEHME 405
Query: 231 RTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKI 290
+ ++ + + +G V +++ L+ + +E+N RL L +I
Sbjct: 406 QCAVKLAKMVGYVSAGTVEY-LYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQI 464
Query: 291 ALGIPLPEIKNV 302
A+GIPL IK++
Sbjct: 465 AMGIPLYRIKDI 476
Score = 34.7 bits (78), Expect = 0.48
Identities = 45/261 (17%), Positives = 85/261 (32%), Gaps = 36/261 (13%)
Query: 607 GQIPNNLAVP--LYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKA------- 657
G N +P L KNG+ MG + D+ S V + PW
Sbjct: 210 GHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDW 269
Query: 658 ---------------------VNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDE 696
V +++ L+ A+ V YP +++ S G + V + D+
Sbjct: 270 QENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADD 329
Query: 697 MKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDAT 756
+ P+ + + + +R +E+ + +AIS D V
Sbjct: 330 FPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQ---YGNAISLFGRDCSVQRRHQK 386
Query: 757 LM--LPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLV-KGNDVLVIECNLRASRSF 813
++ P + E ++ K+AK V++L + +E N R
Sbjct: 387 IIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEH 446
Query: 814 PFVSKTLGVDFIDVATKVMIG 834
P V+ ++ +G
Sbjct: 447 PCTEMVADVNLPAAQLQIAMG 467
>gi|38679974 acetyl-Coenzyme A carboxylase alpha isoform 4 [Homo
sapiens]
Length = 2268
Score = 65.1 bits (157), Expect = 3e-10
Identities = 53/252 (21%), Positives = 110/252 (43%), Gaps = 9/252 (3%)
Query: 55 LGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSF 114
+G Q G ++ V + G+ L S + FS ++ + +++
Sbjct: 152 MGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKG 211
Query: 115 AVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDL--STKAFAMTNQILVE 172
V+ ++D L+AA+ +GYPVMI+++ GG G N + +L +A + I V
Sbjct: 212 YVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVM 271
Query: 173 KSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVV--APAQTLSNAEFQMLR 230
+ + +E +++ D N +++ + V ++ APA + A F+ +
Sbjct: 272 RLAKQSRHLEVQILADQYGNAISLFGRD----CSVQRRHQKIIEEAPATIATPAVFEHME 327
Query: 231 RTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKI 290
+ ++ + + +G V +++ L+ + +E+N RL L +I
Sbjct: 328 QCAVKLAKMVGYVSAGTVEY-LYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQI 386
Query: 291 ALGIPLPEIKNV 302
A+GIPL IK++
Sbjct: 387 AMGIPLYRIKDI 398
Score = 34.7 bits (78), Expect = 0.48
Identities = 45/261 (17%), Positives = 85/261 (32%), Gaps = 36/261 (13%)
Query: 607 GQIPNNLAVP--LYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKA------- 657
G N +P L KNG+ MG + D+ S V + PW
Sbjct: 132 GHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDW 191
Query: 658 ---------------------VNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDE 696
V +++ L+ A+ V YP +++ S G + V + D+
Sbjct: 192 QENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADD 251
Query: 697 MKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDAT 756
+ P+ + + + +R +E+ + +AIS D V
Sbjct: 252 FPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQ---YGNAISLFGRDCSVQRRHQK 308
Query: 757 LM--LPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLV-KGNDVLVIECNLRASRSF 813
++ P + E ++ K+AK V++L + +E N R
Sbjct: 309 IIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEH 368
Query: 814 PFVSKTLGVDFIDVATKVMIG 834
P V+ ++ +G
Sbjct: 369 PCTEMVADVNLPAAQLQIAMG 389
>gi|38679971 acetyl-Coenzyme A carboxylase alpha isoform 3 [Homo
sapiens]
Length = 2288
Score = 65.1 bits (157), Expect = 3e-10
Identities = 53/252 (21%), Positives = 110/252 (43%), Gaps = 9/252 (3%)
Query: 55 LGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSF 114
+G Q G ++ V + G+ L S + FS ++ + +++
Sbjct: 172 MGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKG 231
Query: 115 AVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDL--STKAFAMTNQILVE 172
V+ ++D L+AA+ +GYPVMI+++ GG G N + +L +A + I V
Sbjct: 232 YVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVM 291
Query: 173 KSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVV--APAQTLSNAEFQMLR 230
+ + +E +++ D N +++ + V ++ APA + A F+ +
Sbjct: 292 RLAKQSRHLEVQILADQYGNAISLFGRD----CSVQRRHQKIIEEAPATIATPAVFEHME 347
Query: 231 RTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKI 290
+ ++ + + +G V +++ L+ + +E+N RL L +I
Sbjct: 348 QCAVKLAKMVGYVSAGTVEY-LYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQI 406
Query: 291 ALGIPLPEIKNV 302
A+GIPL IK++
Sbjct: 407 AMGIPLYRIKDI 418
Score = 34.7 bits (78), Expect = 0.48
Identities = 45/261 (17%), Positives = 85/261 (32%), Gaps = 36/261 (13%)
Query: 607 GQIPNNLAVP--LYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKA------- 657
G N +P L KNG+ MG + D+ S V + PW
Sbjct: 152 GHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDW 211
Query: 658 ---------------------VNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDE 696
V +++ L+ A+ V YP +++ S G + V + D+
Sbjct: 212 QENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADD 271
Query: 697 MKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDAT 756
+ P+ + + + +R +E+ + +AIS D V
Sbjct: 272 FPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQ---YGNAISLFGRDCSVQRRHQK 328
Query: 757 LM--LPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLV-KGNDVLVIECNLRASRSF 813
++ P + E ++ K+AK V++L + +E N R
Sbjct: 329 IIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEH 388
Query: 814 PFVSKTLGVDFIDVATKVMIG 834
P V+ ++ +G
Sbjct: 389 PCTEMVADVNLPAAQLQIAMG 409
>gi|38679967 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo
sapiens]
Length = 2346
Score = 65.1 bits (157), Expect = 3e-10
Identities = 53/252 (21%), Positives = 110/252 (43%), Gaps = 9/252 (3%)
Query: 55 LGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSF 114
+G Q G ++ V + G+ L S + FS ++ + +++
Sbjct: 230 MGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKG 289
Query: 115 AVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDL--STKAFAMTNQILVE 172
V+ ++D L+AA+ +GYPVMI+++ GG G N + +L +A + I V
Sbjct: 290 YVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVM 349
Query: 173 KSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVV--APAQTLSNAEFQMLR 230
+ + +E +++ D N +++ + V ++ APA + A F+ +
Sbjct: 350 RLAKQSRHLEVQILADQYGNAISLFGRD----CSVQRRHQKIIEEAPATIATPAVFEHME 405
Query: 231 RTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKI 290
+ ++ + + +G V +++ L+ + +E+N RL L +I
Sbjct: 406 QCAVKLAKMVGYVSAGTVEY-LYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQI 464
Query: 291 ALGIPLPEIKNV 302
A+GIPL IK++
Sbjct: 465 AMGIPLYRIKDI 476
Score = 34.7 bits (78), Expect = 0.48
Identities = 45/261 (17%), Positives = 85/261 (32%), Gaps = 36/261 (13%)
Query: 607 GQIPNNLAVP--LYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKA------- 657
G N +P L KNG+ MG + D+ S V + PW
Sbjct: 210 GHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDW 269
Query: 658 ---------------------VNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDE 696
V +++ L+ A+ V YP +++ S G + V + D+
Sbjct: 270 QENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADD 329
Query: 697 MKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDAT 756
+ P+ + + + +R +E+ + +AIS D V
Sbjct: 330 FPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQ---YGNAISLFGRDCSVQRRHQK 386
Query: 757 LM--LPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLV-KGNDVLVIECNLRASRSF 813
++ P + E ++ K+AK V++L + +E N R
Sbjct: 387 IIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEH 446
Query: 814 PFVSKTLGVDFIDVATKVMIG 834
P V+ ++ +G
Sbjct: 447 PCTEMVADVNLPAAQLQIAMG 467
>gi|38679960 acetyl-Coenzyme A carboxylase alpha isoform 1 [Homo
sapiens]
Length = 2383
Score = 65.1 bits (157), Expect = 3e-10
Identities = 53/252 (21%), Positives = 110/252 (43%), Gaps = 9/252 (3%)
Query: 55 LGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSF 114
+G Q G ++ V + G+ L S + FS ++ + +++
Sbjct: 267 MGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKG 326
Query: 115 AVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDL--STKAFAMTNQILVE 172
V+ ++D L+AA+ +GYPVMI+++ GG G N + +L +A + I V
Sbjct: 327 YVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVM 386
Query: 173 KSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVV--APAQTLSNAEFQMLR 230
+ + +E +++ D N +++ + V ++ APA + A F+ +
Sbjct: 387 RLAKQSRHLEVQILADQYGNAISLFGRD----CSVQRRHQKIIEEAPATIATPAVFEHME 442
Query: 231 RTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKI 290
+ ++ + + +G V +++ L+ + +E+N RL L +I
Sbjct: 443 QCAVKLAKMVGYVSAGTVEY-LYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQI 501
Query: 291 ALGIPLPEIKNV 302
A+GIPL IK++
Sbjct: 502 AMGIPLYRIKDI 513
Score = 34.7 bits (78), Expect = 0.48
Identities = 45/261 (17%), Positives = 85/261 (32%), Gaps = 36/261 (13%)
Query: 607 GQIPNNLAVP--LYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKA------- 657
G N +P L KNG+ MG + D+ S V + PW
Sbjct: 247 GHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDW 306
Query: 658 ---------------------VNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDE 696
V +++ L+ A+ V YP +++ S G + V + D+
Sbjct: 307 QENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADD 366
Query: 697 MKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDAT 756
+ P+ + + + +R +E+ + +AIS D V
Sbjct: 367 FPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQ---YGNAISLFGRDCSVQRRHQK 423
Query: 757 LM--LPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLV-KGNDVLVIECNLRASRSF 813
++ P + E ++ K+AK V++L + +E N R
Sbjct: 424 IIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEH 483
Query: 814 PFVSKTLGVDFIDVATKVMIG 834
P V+ ++ +G
Sbjct: 484 PCTEMVADVNLPAAQLQIAMG 504
>gi|116805327 methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
precursor [Homo sapiens]
Length = 725
Score = 62.4 bits (150), Expect = 2e-09
Identities = 72/310 (23%), Positives = 124/310 (40%), Gaps = 27/310 (8%)
Query: 549 IRTLRQLGKKTVVVNCNPETVSTDFDECDKLYF--------EELSLERILDIYHQEACGG 600
+RT ++LG +TV V + S D D+ Y LS+E+I+ + A
Sbjct: 65 MRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTSAAQA 124
Query: 601 CIISVGGQIPNNLAVPLYK-NGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAP----W 655
G N L K G+ +G P I D I S + A P +
Sbjct: 125 IHPGCGFLSENMEFAELCKQEGIIFIGPPPSAI---RDMGIKSTSKSIMAAAGVPVVEGY 181
Query: 656 KAVNTLNEAL-EFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQ----E 710
+ ++ L E A+ + YP +++ G M +V SE E ++ LE A R ++ +
Sbjct: 182 HGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFND 241
Query: 711 HPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLM--LPTQTISQGA 768
+++ KFV+ R VE+ G +A+ D V ++ P I
Sbjct: 242 DAMLIEKFVDTPRHVEVQVFGDHH---GNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEV 298
Query: 769 IEKVKDATRKIAKAFAISGPFNVQFLVKG-NDVLVIECNLRASRSFPFVSKTLGVDFIDV 827
+K+ +A + AKA G V+F++ ++ +E N R P G D ++
Sbjct: 299 RKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEW 358
Query: 828 ATKVMIGENV 837
++ GE +
Sbjct: 359 QLRIAAGEKI 368
Score = 48.1 bits (113), Expect = 4e-05
Identities = 42/178 (23%), Positives = 74/178 (41%), Gaps = 9/178 (5%)
Query: 126 ADTIGYPVMIRSAYALGGLGSGICPNRETLMD------LSTKAFAMTNQILVEKSVTGWK 179
A IGYPVMI++ GG G I + + + K + +L+EK V +
Sbjct: 195 ARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPR 254
Query: 180 EIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRH 239
+E +V D N V + E ++ + APA + + + L ++ +
Sbjct: 255 HVEVQVFGDHHGNAVYL--FERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKA 312
Query: 240 LGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLP 297
+ VG ++F + + +C +E+N RL + TG L +IA G +P
Sbjct: 313 VNYVGAGTVEFIM-DSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIP 369
>gi|106049528 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 56.2 bits (134), Expect = 2e-07
Identities = 52/233 (22%), Positives = 99/233 (42%), Gaps = 13/233 (5%)
Query: 76 KEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSF--AVESIEDALKAADTIGYPV 133
++ GV+ +G S E + D+ + P + S+ +A + ++T G+P+
Sbjct: 132 QDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPI 191
Query: 134 MIRSAYALGGLGSGICPNRETLMDLSTKAFAM------TNQILVEKSVTGWKEIEYEVVR 187
+ ++AY GG G + + E L + T+A++ + VEK + + IE +++
Sbjct: 192 IFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILG 251
Query: 188 DADDNCVTVCNMENVDAMGVHTGDSVV-VAPAQTLSNAEFQMLRRTSINVVRHLGIVGEC 246
D N + ++ D VV +APA L L S+ + + +G
Sbjct: 252 DQYGN---ILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAG 308
Query: 247 NIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEI 299
++F + Y IEVN+RL + + T L +A G LP++
Sbjct: 309 TVEFLVDRHGKHY-FIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDL 360
>gi|106049295 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 56.2 bits (134), Expect = 2e-07
Identities = 52/233 (22%), Positives = 99/233 (42%), Gaps = 13/233 (5%)
Query: 76 KEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSF--AVESIEDALKAADTIGYPV 133
++ GV+ +G S E + D+ + P + S+ +A + ++T G+P+
Sbjct: 132 QDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPI 191
Query: 134 MIRSAYALGGLGSGICPNRETLMDLSTKAFAM------TNQILVEKSVTGWKEIEYEVVR 187
+ ++AY GG G + + E L + T+A++ + VEK + + IE +++
Sbjct: 192 IFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILG 251
Query: 188 DADDNCVTVCNMENVDAMGVHTGDSVV-VAPAQTLSNAEFQMLRRTSINVVRHLGIVGEC 246
D N + ++ D VV +APA L L S+ + + +G
Sbjct: 252 DQYGN---ILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAG 308
Query: 247 NIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEI 299
++F + Y IEVN+RL + + T L +A G LP++
Sbjct: 309 TVEFLVDRHGKHY-FIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDL 360
>gi|106049292 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 56.2 bits (134), Expect = 2e-07
Identities = 52/233 (22%), Positives = 99/233 (42%), Gaps = 13/233 (5%)
Query: 76 KEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSF--AVESIEDALKAADTIGYPV 133
++ GV+ +G S E + D+ + P + S+ +A + ++T G+P+
Sbjct: 132 QDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPI 191
Query: 134 MIRSAYALGGLGSGICPNRETLMDLSTKAFAM------TNQILVEKSVTGWKEIEYEVVR 187
+ ++AY GG G + + E L + T+A++ + VEK + + IE +++
Sbjct: 192 IFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILG 251
Query: 188 DADDNCVTVCNMENVDAMGVHTGDSVV-VAPAQTLSNAEFQMLRRTSINVVRHLGIVGEC 246
D N + ++ D VV +APA L L S+ + + +G
Sbjct: 252 DQYGN---ILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAG 308
Query: 247 NIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEI 299
++F + Y IEVN+RL + + T L +A G LP++
Sbjct: 309 TVEFLVDRHGKHY-FIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDL 360
>gi|65506442 propionyl-Coenzyme A carboxylase, alpha polypeptide
isoform a precursor [Homo sapiens]
Length = 728
Score = 54.3 bits (129), Expect = 6e-07
Identities = 77/314 (24%), Positives = 135/314 (42%), Gaps = 33/314 (10%)
Query: 2 KEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITP--------QFVTEVIKAEQPDGL 53
K+ +KTV ++ + V + V +K AD + P + E IK + +
Sbjct: 83 KKMGIKTVAIH---SDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAV 139
Query: 54 ILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDR---QLFSDKLNEINEKI 110
G G L+ E F R + E V +G +I A D+ +L + K E+N
Sbjct: 140 HPGYG---FLSENKE-FARCLAAE-DVVFIGPDTHAIQAMGDKIESKLLAKKA-EVNTIP 193
Query: 111 APSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMD---LSTKAFAMT- 166
V+ E+A++ A IGYPVMI+++ GG G I + E D LS++ A +
Sbjct: 194 GFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSF 253
Query: 167 --NQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVV--APAQTLS 222
+++L+EK + + IE +V+ D N + + N + + VV AP+ L
Sbjct: 254 GDDRLLIEKFIDNPRHIEIQVLGDKHGNALWL----NERECSIQRRNQKVVEEAPSIFLD 309
Query: 223 NAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYP 282
+ + ++ + R + ++F L + + +E+N RL + TG
Sbjct: 310 AETRRAMGEQAVALARAVKYSSAGTVEF-LVDSKKNFYFLEMNTRLQVEHPVTECITGLD 368
Query: 283 LAFIAAKIALGIPL 296
L ++A G PL
Sbjct: 369 LVQEMIRVAKGYPL 382
Score = 43.9 bits (102), Expect = 8e-04
Identities = 60/311 (19%), Positives = 117/311 (37%), Gaps = 35/311 (11%)
Query: 549 IRTLRQLGKKTVVVNCNPETVSTDFDECDKLYF--------EELSLERILDIYHQEACGG 600
IRT +++G KTV ++ + + S D+ L+++ I++ +
Sbjct: 79 IRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQA 138
Query: 601 CIISVGGQIPNN-LAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPW--KA 657
G N A L V +G I D+ + + +V P
Sbjct: 139 VHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGV 198
Query: 658 VNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFL----EEATRVSQEHPV 713
V EA+ A+ + YP +++ S G M + + ++E + +EA + +
Sbjct: 199 VKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRL 258
Query: 714 VLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVK 773
++ KF++ R +E+ +G +H ++ + ++ Q + + A
Sbjct: 259 LIEKFIDNPRHIEIQVLG----------DKHGNALWLNERECSIQRRNQKVVEEAPSIFL 308
Query: 774 DA-TRK--------IAKAFAISGPFNVQFLVKG-NDVLVIECNLRASRSFPFVSKTLGVD 823
DA TR+ +A+A S V+FLV + +E N R P G+D
Sbjct: 309 DAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLD 368
Query: 824 FIDVATKVMIG 834
+ +V G
Sbjct: 369 LVQEMIRVAKG 379
>gi|189095269 propionyl-Coenzyme A carboxylase, alpha polypeptide
isoform b [Homo sapiens]
Length = 702
Score = 54.3 bits (129), Expect = 6e-07
Identities = 77/314 (24%), Positives = 135/314 (42%), Gaps = 33/314 (10%)
Query: 2 KEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITP--------QFVTEVIKAEQPDGL 53
K+ +KTV ++ + V + V +K AD + P + E IK + +
Sbjct: 57 KKMGIKTVAIH---SDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAV 113
Query: 54 ILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDR---QLFSDKLNEINEKI 110
G G L+ E F R + E V +G +I A D+ +L + K E+N
Sbjct: 114 HPGYG---FLSENKE-FARCLAAE-DVVFIGPDTHAIQAMGDKIESKLLAKKA-EVNTIP 167
Query: 111 APSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMD---LSTKAFAMT- 166
V+ E+A++ A IGYPVMI+++ GG G I + E D LS++ A +
Sbjct: 168 GFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSF 227
Query: 167 --NQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVV--APAQTLS 222
+++L+EK + + IE +V+ D N + + N + + VV AP+ L
Sbjct: 228 GDDRLLIEKFIDNPRHIEIQVLGDKHGNALWL----NERECSIQRRNQKVVEEAPSIFLD 283
Query: 223 NAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYP 282
+ + ++ + R + ++F L + + +E+N RL + TG
Sbjct: 284 AETRRAMGEQAVALARAVKYSSAGTVEF-LVDSKKNFYFLEMNTRLQVEHPVTECITGLD 342
Query: 283 LAFIAAKIALGIPL 296
L ++A G PL
Sbjct: 343 LVQEMIRVAKGYPL 356
Score = 43.9 bits (102), Expect = 8e-04
Identities = 60/311 (19%), Positives = 117/311 (37%), Gaps = 35/311 (11%)
Query: 549 IRTLRQLGKKTVVVNCNPETVSTDFDECDKLYF--------EELSLERILDIYHQEACGG 600
IRT +++G KTV ++ + + S D+ L+++ I++ +
Sbjct: 53 IRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQA 112
Query: 601 CIISVGGQIPNN-LAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPW--KA 657
G N A L V +G I D+ + + +V P
Sbjct: 113 VHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGV 172
Query: 658 VNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFL----EEATRVSQEHPV 713
V EA+ A+ + YP +++ S G M + + ++E + +EA + +
Sbjct: 173 VKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRL 232
Query: 714 VLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVK 773
++ KF++ R +E+ +G +H ++ + ++ Q + + A
Sbjct: 233 LIEKFIDNPRHIEIQVLG----------DKHGNALWLNERECSIQRRNQKVVEEAPSIFL 282
Query: 774 DA-TRK--------IAKAFAISGPFNVQFLVKG-NDVLVIECNLRASRSFPFVSKTLGVD 823
DA TR+ +A+A S V+FLV + +E N R P G+D
Sbjct: 283 DAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLD 342
Query: 824 FIDVATKVMIG 834
+ +V G
Sbjct: 343 LVQEMIRVAKG 353
>gi|134142062 acetyl-Coenzyme A carboxylase beta [Homo sapiens]
Length = 2458
Score = 53.9 bits (128), Expect = 8e-07
Identities = 47/216 (21%), Positives = 97/216 (44%), Gaps = 14/216 (6%)
Query: 93 TEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNR 152
TED L K + E + V+ +++ L+AA+ IG+P+MI+++ GG G +
Sbjct: 412 TED-DLQQGKRISVPEDVYDKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESA 470
Query: 153 E--TLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTV----CNMENVDAMG 206
E ++ ++ + I + K + +E +++ D N V++ C+++
Sbjct: 471 EDFPILFRQVQSEIPGSPIFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQR----- 525
Query: 207 VHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNA 266
V APA A F+ + + +I + + +G V +++ L+ + +E+N
Sbjct: 526 -RHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEY-LYSQDGSFHFLELNP 583
Query: 267 RLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNV 302
RL L +IA+G+PL +K++
Sbjct: 584 RLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDI 619
>gi|28416899 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase isoform 2 [Homo
sapiens]
Length = 433
Score = 37.7 bits (86), Expect = 0.057
Identities = 35/165 (21%), Positives = 68/165 (41%), Gaps = 13/165 (7%)
Query: 621 GVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCL-LRP 679
GV+ G + + +D + A WKA EA F S D+P L ++
Sbjct: 90 GVQCFGPTAEAAQLESSKRFAKEFMDRHGIPTAQWKAFTKPEEACSFILSADFPALVVKA 149
Query: 680 SYVLSGSAMNVVFSEDE----MKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGR 735
S + +G + V S++E +++ ++E + +V+ + ++G E DG+
Sbjct: 150 SGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIEELLDG--EEVSCLCFTDGK 207
Query: 736 VIS--HAISEHVE----DAGVHSGDATLMLPTQTISQGAIEKVKD 774
++ +H D G ++G P +S + K+KD
Sbjct: 208 TVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAPQVSNDLLLKIKD 252
>gi|4503915 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase isoform 1 [Homo
sapiens]
Length = 1010
Score = 37.7 bits (86), Expect = 0.057
Identities = 35/165 (21%), Positives = 68/165 (41%), Gaps = 13/165 (7%)
Query: 621 GVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCL-LRP 679
GV+ G + + +D + A WKA EA F S D+P L ++
Sbjct: 90 GVQCFGPTAEAAQLESSKRFAKEFMDRHGIPTAQWKAFTKPEEACSFILSADFPALVVKA 149
Query: 680 SYVLSGSAMNVVFSEDE----MKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGR 735
S + +G + V S++E +++ ++E + +V+ + ++G E DG+
Sbjct: 150 SGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIEELLDG--EEVSCLCFTDGK 207
Query: 736 VIS--HAISEHVE----DAGVHSGDATLMLPTQTISQGAIEKVKD 774
++ +H D G ++G P +S + K+KD
Sbjct: 208 TVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAPQVSNDLLLKIKD 252
>gi|209869995 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase isoform 1 [Homo
sapiens]
Length = 1010
Score = 37.7 bits (86), Expect = 0.057
Identities = 35/165 (21%), Positives = 68/165 (41%), Gaps = 13/165 (7%)
Query: 621 GVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCL-LRP 679
GV+ G + + +D + A WKA EA F S D+P L ++
Sbjct: 90 GVQCFGPTAEAAQLESSKRFAKEFMDRHGIPTAQWKAFTKPEEACSFILSADFPALVVKA 149
Query: 680 SYVLSGSAMNVVFSEDE----MKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGR 735
S + +G + V S++E +++ ++E + +V+ + ++G E DG+
Sbjct: 150 SGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIEELLDG--EEVSCLCFTDGK 207
Query: 736 VIS--HAISEHVE----DAGVHSGDATLMLPTQTISQGAIEKVKD 774
++ +H D G ++G P +S + K+KD
Sbjct: 208 TVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAPQVSNDLLLKIKD 252
>gi|209869993 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase isoform 1 [Homo
sapiens]
Length = 1010
Score = 37.7 bits (86), Expect = 0.057
Identities = 35/165 (21%), Positives = 68/165 (41%), Gaps = 13/165 (7%)
Query: 621 GVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCL-LRP 679
GV+ G + + +D + A WKA EA F S D+P L ++
Sbjct: 90 GVQCFGPTAEAAQLESSKRFAKEFMDRHGIPTAQWKAFTKPEEACSFILSADFPALVVKA 149
Query: 680 SYVLSGSAMNVVFSEDE----MKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGR 735
S + +G + V S++E +++ ++E + +V+ + ++G E DG+
Sbjct: 150 SGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIEELLDG--EEVSCLCFTDGK 207
Query: 736 VIS--HAISEHVE----DAGVHSGDATLMLPTQTISQGAIEKVKD 774
++ +H D G ++G P +S + K+KD
Sbjct: 208 TVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAPQVSNDLLLKIKD 252
>gi|148839342 ATP-grasp domain containing 1 [Homo sapiens]
Length = 827
Score = 35.0 bits (79), Expect = 0.37
Identities = 31/124 (25%), Positives = 56/124 (45%), Gaps = 3/124 (2%)
Query: 713 VVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKV 772
++L +FVEG E ++D V GR+++ +S++ + +PT + + V
Sbjct: 599 MLLMEFVEGT-EHDVDLVLFGGRLLAAFVSDNGPTRLPGFTETAACMPTGLAPEQEAQMV 657
Query: 773 KDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSF--PFVSKTLGVDFIDVATK 830
+ A R + G FNV+ + G +IE N R + ++ + GVD + A
Sbjct: 658 QAAFRCCLGCGLLDGVFNVELKLTGAGPRLIEINPRMGGFYLRDWILELYGVDLLLAAVM 717
Query: 831 VMIG 834
V G
Sbjct: 718 VACG 721
>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
Length = 1617
Score = 32.7 bits (73), Expect = 1.8
Identities = 23/102 (22%), Positives = 50/102 (49%), Gaps = 5/102 (4%)
Query: 384 SNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWF-----LYKMRDILNMEK 438
S L++ LS P+ + K + + L+EI K+T + F + +++ L++
Sbjct: 522 SLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFA 581
Query: 439 TLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTREL 480
+KG++ + + +E + E+ + Q + L+E Q R+L
Sbjct: 582 KIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKL 623
>gi|24308398 transmembrane protein 116 [Homo sapiens]
Length = 245
Score = 32.0 bits (71), Expect = 3.1
Identities = 18/65 (27%), Positives = 33/65 (50%), Gaps = 5/65 (7%)
Query: 161 KAFAMTNQILVEKSVTGWKE-----IEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVV 215
+A T+Q L+ V GW + ++ E RDAD +C+ + + G+++ +S +
Sbjct: 177 QALTATSQGLLNCGVYGWTQHKFHQLKQEARRDADTQTPLLCSQKRFYSRGLNSLESTLT 236
Query: 216 APAQT 220
PA T
Sbjct: 237 FPAST 241
>gi|110611228 utrophin [Homo sapiens]
Length = 3433
Score = 30.8 bits (68), Expect = 7.0
Identities = 33/131 (25%), Positives = 58/131 (44%), Gaps = 23/131 (17%)
Query: 389 RKELSEPSSTRIYAIAKAIDDNMSLDEI--EKLTYIDKWFL----------YKMRDILNM 436
++EL P + I I+ D I E L +I KW KM+D M
Sbjct: 668 KQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEM 727
Query: 437 EKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTL 496
+K LK L E E + RA E+ + + + + +G T E+ KN+ ++ +
Sbjct: 728 KKKLKALEKEQ--RERIPRADELNQTGQILVEQMGKEGLPTEEI---KNV------LEKV 776
Query: 497 AAEYPSVTNYL 507
++E+ +V+ +L
Sbjct: 777 SSEWKNVSQHL 787
>gi|154759423 Cdk5 and Abl enzyme substrate 1 isoform 2 [Homo
sapiens]
Length = 633
Score = 30.4 bits (67), Expect = 9.1
Identities = 20/70 (28%), Positives = 40/70 (57%), Gaps = 7/70 (10%)
Query: 546 VSSIRTLRQLGKKTVVVNCNPE--TVSTDFDECDKLYFEELSLERILDIYHQEACGGCII 603
+S IR+L++ +K +C E TV+ F +YFE+L+L+ L+ +++ C G +
Sbjct: 513 LSKIRSLKREMRKLAQEDCGLEEPTVAMAF-----VYFEKLALKGKLNKQNRKLCAGACV 567
Query: 604 SVGGQIPNNL 613
+ +I ++L
Sbjct: 568 LLAAKIGSDL 577
>gi|24308408 Cdk5 and Abl enzyme substrate 1 isoform 1 [Homo
sapiens]
Length = 368
Score = 30.4 bits (67), Expect = 9.1
Identities = 20/70 (28%), Positives = 40/70 (57%), Gaps = 7/70 (10%)
Query: 546 VSSIRTLRQLGKKTVVVNCNPE--TVSTDFDECDKLYFEELSLERILDIYHQEACGGCII 603
+S IR+L++ +K +C E TV+ F +YFE+L+L+ L+ +++ C G +
Sbjct: 248 LSKIRSLKREMRKLAQEDCGLEEPTVAMAF-----VYFEKLALKGKLNKQNRKLCAGACV 302
Query: 604 SVGGQIPNNL 613
+ +I ++L
Sbjct: 303 LLAAKIGSDL 312
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,157,307
Number of Sequences: 37866
Number of extensions: 1476803
Number of successful extensions: 3418
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 3317
Number of HSP's gapped (non-prelim): 55
length of query: 1049
length of database: 18,247,518
effective HSP length: 113
effective length of query: 936
effective length of database: 13,968,660
effective search space: 13074665760
effective search space used: 13074665760
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.