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Search of human proteins with 169646281
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169646281 coiled-coil domain containing 14 [Homo sapiens]
(912 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169646281 coiled-coil domain containing 14 [Homo sapiens] 1791 0.0
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 64 8e-10
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 61 4e-09
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 61 4e-09
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 60 9e-09
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 60 9e-09
gi|31982906 cingulin-like 1 [Homo sapiens] 57 6e-08
gi|71061468 centromere protein E [Homo sapiens] 55 3e-07
gi|224586823 coiled-coil domain containing 110 isoform b [Homo s... 54 7e-07
gi|22749515 coiled-coil domain containing 110 isoform a [Homo sa... 54 7e-07
gi|55770834 centromere protein F [Homo sapiens] 54 9e-07
gi|21735548 centrosomal protein 2 [Homo sapiens] 53 1e-06
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 53 1e-06
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 52 3e-06
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 52 3e-06
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 52 3e-06
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 52 3e-06
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom... 52 3e-06
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 52 3e-06
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 51 6e-06
gi|4505541 USO1 homolog, vesicle docking protein [Homo sapiens] 50 7e-06
gi|156104908 myosin heavy chain 6 [Homo sapiens] 50 7e-06
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 50 1e-05
gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens] 50 1e-05
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 50 1e-05
gi|34878777 ring finger protein 20 [Homo sapiens] 49 2e-05
gi|7705415 hook homolog 1 [Homo sapiens] 49 2e-05
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 49 2e-05
gi|109659849 filamin A interacting protein 1-like isoform 2 [Hom... 49 2e-05
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 49 2e-05
>gi|169646281 coiled-coil domain containing 14 [Homo sapiens]
Length = 912
Score = 1791 bits (4638), Expect = 0.0
Identities = 912/912 (100%), Positives = 912/912 (100%)
Query: 1 MKRGIRRDPFRKRKLGGRAKKVREPTAVNSFYREASLPSVWASLRRREMVRSGARPGQVL 60
MKRGIRRDPFRKRKLGGRAKKVREPTAVNSFYREASLPSVWASLRRREMVRSGARPGQVL
Sbjct: 1 MKRGIRRDPFRKRKLGGRAKKVREPTAVNSFYREASLPSVWASLRRREMVRSGARPGQVL 60
Query: 61 SSGRHTGPAKLTNGKKATYLRKIPRFNADSGYSIHSDSESQAETVHGLDGCASLLRDILR 120
SSGRHTGPAKLTNGKKATYLRKIPRFNADSGYSIHSDSESQAETVHGLDGCASLLRDILR
Sbjct: 61 SSGRHTGPAKLTNGKKATYLRKIPRFNADSGYSIHSDSESQAETVHGLDGCASLLRDILR 120
Query: 121 NEDSASSDNKKQIPNEASARSERDTSDLEQNWSLQDHYRMYSPIIYQALCEHVQTQMSLM 180
NEDSASSDNKKQIPNEASARSERDTSDLEQNWSLQDHYRMYSPIIYQALCEHVQTQMSLM
Sbjct: 121 NEDSASSDNKKQIPNEASARSERDTSDLEQNWSLQDHYRMYSPIIYQALCEHVQTQMSLM 180
Query: 181 NDLTSKNIPNGIPAVPCHAPSHSESQATPHSSYGLCTSTPVWSLQRPPCPPKVHSEVQTD 240
NDLTSKNIPNGIPAVPCHAPSHSESQATPHSSYGLCTSTPVWSLQRPPCPPKVHSEVQTD
Sbjct: 181 NDLTSKNIPNGIPAVPCHAPSHSESQATPHSSYGLCTSTPVWSLQRPPCPPKVHSEVQTD 240
Query: 241 GNSQFASQGKTVSATCTDVLRNSFNTSPGVPCSLPKTDISAIPTLQQLGLVNGILPQQGI 300
GNSQFASQGKTVSATCTDVLRNSFNTSPGVPCSLPKTDISAIPTLQQLGLVNGILPQQGI
Sbjct: 241 GNSQFASQGKTVSATCTDVLRNSFNTSPGVPCSLPKTDISAIPTLQQLGLVNGILPQQGI 300
Query: 301 HKETDLLKCIQTYLSLFRSHGKETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSE 360
HKETDLLKCIQTYLSLFRSHGKETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSE
Sbjct: 301 HKETDLLKCIQTYLSLFRSHGKETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSE 360
Query: 361 RKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITEME 420
RKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITEME
Sbjct: 361 RKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITEME 420
Query: 421 ACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCN 480
ACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCN
Sbjct: 421 ACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCN 480
Query: 481 LELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTIL 540
LELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTIL
Sbjct: 481 LELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTIL 540
Query: 541 ENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTR 600
ENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTR
Sbjct: 541 ENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTR 600
Query: 601 TLQTSMAKLLSDLSVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLETNY 660
TLQTSMAKLLSDLSVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLETNY
Sbjct: 601 TLQTSMAKLLSDLSVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLETNY 660
Query: 661 SFTHSEPLSTIKNEETIEPDKTYENVLSSRGPQNSNTRGMEEASAPGIISALSKQDSDEG 720
SFTHSEPLSTIKNEETIEPDKTYENVLSSRGPQNSNTRGMEEASAPGIISALSKQDSDEG
Sbjct: 661 SFTHSEPLSTIKNEETIEPDKTYENVLSSRGPQNSNTRGMEEASAPGIISALSKQDSDEG 720
Query: 721 SETMALIEDEHNLDNTIYIPFARSTPEKKSPLSKRLSPQPQIRAATTQLVSNSGLAVSGK 780
SETMALIEDEHNLDNTIYIPFARSTPEKKSPLSKRLSPQPQIRAATTQLVSNSGLAVSGK
Sbjct: 721 SETMALIEDEHNLDNTIYIPFARSTPEKKSPLSKRLSPQPQIRAATTQLVSNSGLAVSGK 780
Query: 781 ENKLCTPVICSSSTKEAEDAPEKLSRASDMKDTQLLKKIKEAIGKIPAATKEPEEQTACH 840
ENKLCTPVICSSSTKEAEDAPEKLSRASDMKDTQLLKKIKEAIGKIPAATKEPEEQTACH
Sbjct: 781 ENKLCTPVICSSSTKEAEDAPEKLSRASDMKDTQLLKKIKEAIGKIPAATKEPEEQTACH 840
Query: 841 GPSGCLSNSLQVKGNTVCDGSVFTSDLMSDWSISSFSTFTSRDEQDFRNGLAALDANIAR 900
GPSGCLSNSLQVKGNTVCDGSVFTSDLMSDWSISSFSTFTSRDEQDFRNGLAALDANIAR
Sbjct: 841 GPSGCLSNSLQVKGNTVCDGSVFTSDLMSDWSISSFSTFTSRDEQDFRNGLAALDANIAR 900
Query: 901 LQKSLRTGLLEK 912
LQKSLRTGLLEK
Sbjct: 901 LQKSLRTGLLEK 912
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin
(with transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 63.5 bits (153), Expect = 8e-10
Identities = 105/494 (21%), Positives = 213/494 (43%), Gaps = 56/494 (11%)
Query: 351 REQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDS 410
+E ++E + + L + ++D KDVQ + E+ + + +LK L A+ + +
Sbjct: 47 QEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLK-LHAKAKLT 105
Query: 411 EIQRLITEMEACI-SVLPT-------VSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQ 462
+ + I EM+A +VLPT +S + E + ++ ++ + + + L
Sbjct: 106 SLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQA 165
Query: 463 QLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQK 522
QL + Q Q + + +E F + + + + +L++Q L Q++ E+ + + +K
Sbjct: 166 QLTQAQAEQPAQSSTE--MEEFVMMKQQLQEKEEFISTLQAQ-LSQTQAEQAAQQVVREK 222
Query: 523 DENKKFSSIFKDKDQTILENKQQYDIE---------ITRIKIELEEALVN----VKSSQF 569
D +F + + + +L+ Q D+E + R E EE+LV V Q
Sbjct: 223 DA--RFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQ 280
Query: 570 KLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKPG-NNLTK 628
+L AE+ NQIL L+Q +AE LR T + LL + ++ A K +NL +
Sbjct: 281 ELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQE 340
Query: 629 SLLNIHDKQLQHDPAPAHTSIMSYLNKLETNYSFTHSEPLSTI--KNEETIEPDKTYENV 686
+ ++ ++ Q A A +LE+ YS + + + K + KT + +
Sbjct: 341 EMHHLLEQFEQAGQAQA---------ELESRYSALEQKHKAEMEEKTSHILSLQKTGQEL 391
Query: 687 LSS-RGPQNSNTRGMEEASAPGIISALSKQDSDEGSETMALIEDEHNLDNTIYIPFARST 745
S+ ++ N++ +++ + + SA +T+ +ED+ + F
Sbjct: 392 QSACDALKDQNSKLLQDKNEQAVQSA----------QTIQQLEDQLQQKSKEISQFLNRL 441
Query: 746 PEKKSPLSKRLSPQPQIRAATTQLVSNSGLAVSGK-----ENKLCTPVICSSSTKEAEDA 800
P ++ + + S P + TQ V+ +A K EN+ ++ S +E +
Sbjct: 442 PLQQHETASQTS-FPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAE 500
Query: 801 PEKLSRASDMKDTQ 814
EKLS + + Q
Sbjct: 501 NEKLSSQITLLEAQ 514
Score = 43.9 bits (102), Expect = 7e-04
Identities = 88/427 (20%), Positives = 169/427 (39%), Gaps = 82/427 (19%)
Query: 341 FLATNEEK---CAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLL 397
F+ T +K +E + +A RK + K + D +++ A+ +++ K L
Sbjct: 2047 FVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQ 2106
Query: 398 GELKALVAE--QEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRR 455
+++ ++ Q+D +++R + + E + ++Q ++ LR E L
Sbjct: 2107 SNKESVKSQMKQKDEDLERRLEQAEE-----KHLKEKKNMQEKL----DALRREKVHLEE 2157
Query: 456 QLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELL 515
+ + L ++ K E+ LQ S QL KS LQ + ++
Sbjct: 2158 TIGEIQVTLNKKDK------------EVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVI 2205
Query: 516 KVIENQKDENKKFSSIFKD----KDQTILENKQQYDI---EITRIKIELEEALVNVKSSQ 568
DE KK+ F D K++ I + + ++ ++ I +EE +N+ +
Sbjct: 2206 -------DEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLE 2258
Query: 569 F-------KLETAEKENQILGITLRQRDAEVTRLRELTRTL----QTSMAKL-------- 609
K +T + Q + TL+ + E+ E TR L Q +AKL
Sbjct: 2259 HDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLK 2318
Query: 610 --LSDLSVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLETNYSFTHSEP 667
L+DLS +CK + ++ + +Q+ S SY +LET+ S
Sbjct: 2319 DQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQN-------SKFSY-EQLETD--LQASRE 2368
Query: 668 LSTIKNEETIEPDKTYENVLSSRGPQNSNTRGMEEASAPGIISALSKQDSD-EGSETMAL 726
L++ +EE ++ ++LS G EEA I + D + + E +
Sbjct: 2369 LTSRLHEEINMKEQKIISLLS----------GKEEAIQVAIAELRQQHDKEIKELENLLS 2418
Query: 727 IEDEHNL 733
E+E N+
Sbjct: 2419 QEEEENI 2425
Score = 37.0 bits (84), Expect = 0.084
Identities = 45/203 (22%), Positives = 95/203 (46%), Gaps = 22/203 (10%)
Query: 436 QVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQ- 494
+VE+ L + SE + ++ L +Q+ +Q LE+ SL++++ +
Sbjct: 1318 KVELELKVSSTTSELTKKSEEVFQLQEQINKQ------------GLEIESLKTVSHEAEV 1365
Query: 495 --NQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENK-QQYDIEIT 551
L++ L+S +L Q E L+ ++ + DE +K S K++D + L + + + +T
Sbjct: 1366 HAESLQQKLESSQL-QIAGLEHLRELQPKLDELQKLISK-KEEDVSYLSGQLSEKEAALT 1423
Query: 552 RIKIEL--EEALVNVKSSQFKLETAEKENQI--LGITLRQRDAEVTRLRELTRTLQTSMA 607
+I+ E+ +E L+ +Q +++ E + +I L + L + + + E +R Q
Sbjct: 1424 KIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQR 1483
Query: 608 KLLSDLSVDSARCKPGNNLTKSL 630
KL + L K +L + L
Sbjct: 1484 KLQAALISRKEALKENKSLQEEL 1506
Score = 36.6 bits (83), Expect = 0.11
Identities = 72/347 (20%), Positives = 140/347 (40%), Gaps = 71/347 (20%)
Query: 327 DSQTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKT-VKDVQ-----KA 380
+SQT ++ + E K +I +E D+ + + T ++ +Q K
Sbjct: 785 ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKE 844
Query: 381 KNVNKTAEKVRIIKYLLGELKALVAEQE--DSEIQRLITEMEACISVLPTVSGNTDIQV- 437
V + AE+VR I + EL ++++E +++ +L+ E + + L D QV
Sbjct: 845 SEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT 904
Query: 438 EIALAMQP----LRSENAQLRRQLRILNQQLR------EQQKTQ---------------- 471
EI+ +M L E L +++ L +QL E +K Q
Sbjct: 905 EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 964
Query: 472 --KPSGAV---DCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENK 526
P+G + + E L+ N + +L+ +L +++ L + L + + N KDE+K
Sbjct: 965 EMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESK 1024
Query: 527 KFSSIFKDKDQTILENKQ-------------------------QYDIEITRIKIELEEAL 561
K + + + + E+K+ + ++E+ I+ +LEE L
Sbjct: 1025 KEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKL 1084
Query: 562 VNVKSSQFKLETAEKENQILGITLRQRD---AEVTRLRELTRTLQTS 605
+ Q ++ NQ L Q D AE++ + + + L TS
Sbjct: 1085 AAEEQFQ---ALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITS 1128
Score = 36.6 bits (83), Expect = 0.11
Identities = 64/329 (19%), Positives = 135/329 (41%), Gaps = 42/329 (12%)
Query: 300 IHKETDLLKCIQTYLSLFRSHGKETHLDSQTHRSPTQSQPAFLATNEEKCARE-QIREAT 358
+ KE ++L +Q+Y ++ + H+ + + +T K E Q++EA
Sbjct: 1611 LQKEYEIL--LQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAE 1668
Query: 359 SERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGE-----LKALVAEQED--SE 411
E +++ +R K QK + + +++R + G+ ++ L++ E
Sbjct: 1669 QEMEEMKEKMRKFAKSKQ-QKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEE 1727
Query: 412 IQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLR-------SENAQLRRQLRILNQQL 464
++R+ E E ++ D ++ +Q L+ S+ A L + NQ
Sbjct: 1728 LERVKMEYETLSKKFQSLMSEKD---SLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTN 1784
Query: 465 REQQKTQKPSGAVD------------CNLELFSLQSLNMSLQNQLEESLKSQELLQSKNE 512
++ TQ G + C+ + S +S N ++ + LQ ++
Sbjct: 1785 VTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQ 1844
Query: 513 --ELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFK 570
E + +E +K +NK+FS +++ T+L D E+ ++ E+ + + + Q +
Sbjct: 1845 LKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEE 1904
Query: 571 L-------ETAEKENQILGITLRQRDAEV 592
L ETAE+E L L + AE+
Sbjct: 1905 LSRVTKLKETAEEEKDDLEERLMNQLAEL 1933
Score = 33.5 bits (75), Expect = 0.93
Identities = 54/252 (21%), Positives = 97/252 (38%), Gaps = 44/252 (17%)
Query: 405 AEQEDSEIQRLITEMEACISVLPTVSGNTDIQVE-IALAMQPLRSENAQLRRQLRILNQ- 462
AE+ +E+ R + EME + ++ + Q++ +M L++ +L L +
Sbjct: 2701 AEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRK 2760
Query: 463 ---------QLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEE 513
QL+EQ + A+ S+N + +N L K + L SK+E+
Sbjct: 2761 YDASLKELAQLKEQGLLNRERDALLSETAF----SMNSTEENSLSHLEKLNQQLLSKDEQ 2816
Query: 514 LLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLET 573
LL + +D + S K L+N++ + + ELE K
Sbjct: 2817 LLHLSSQLEDSYNQVQSF--SKAMASLQNERDH------LWNELE-----------KFRK 2857
Query: 574 AEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKSLLNI 633
+E+ Q AEV L++ +LQ +LL +L NL + L I
Sbjct: 2858 SEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKEL----------KNLQQQYLQI 2907
Query: 634 HDKQLQHDPAPA 645
+ + + P A
Sbjct: 2908 NQEITELHPLKA 2919
Score = 32.7 bits (73), Expect = 1.6
Identities = 34/167 (20%), Positives = 74/167 (44%), Gaps = 11/167 (6%)
Query: 443 MQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLK 502
++ LRS ++Q + L++ Q+ + + P G+ + ++ + L L + L+E +
Sbjct: 2988 IRELRSSSSQTQ-PLKVQYQRQASPETSASPDGSQNL---VYETELLRTQLNDSLKEIHQ 3043
Query: 503 SQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALV 562
+ +Q N +++E E S D Q++ EN+Q Y + + LE+ +
Sbjct: 3044 KELRIQQLNSNFSQLLE----EKNTLSIQLCDTSQSLRENQQHYGDLLNHCAV-LEKQVQ 3098
Query: 563 NVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKL 609
+++ ++ A Q R+ D E LRE ++ + +L
Sbjct: 3099 ELQAGPLNIDVAPGAPQEKNGVHRKSDPE--ELREPQQSFSEAQQQL 3143
Score = 31.6 bits (70), Expect = 3.5
Identities = 70/347 (20%), Positives = 142/347 (40%), Gaps = 53/347 (15%)
Query: 298 QGIHKETDLLKCIQTYLSLFRSHGKE-THLDSQTHRSPTQSQPAFLATNEEKCAREQ--- 353
QG +KE LL ++ L+ S E L+S+ + Q L+ + EKC ++
Sbjct: 2283 QGENKE--LLSQLEETRHLYHSSQNELAKLESEL--KSLKDQLTDLSNSLEKCKEQKGNL 2338
Query: 354 ---IREATSERKDLNIHVRDTKTVKDVQKAKNVNK------TAEKVRIIKYLLGELKAL- 403
IR+ ++ ++ +T D+Q ++ + ++ +II L G+ +A+
Sbjct: 2339 EGIIRQQEADIQNSKFSYEQLET--DLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQ 2396
Query: 404 -----VAEQEDSEIQRLIT----EMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLR 454
+ +Q D EI+ L E E I + D ++ ++ ++ EN Q +
Sbjct: 2397 VAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQK 2456
Query: 455 RQLRILNQQLREQQKT---------QKPSGAVDCNLELFSLQSLNMSLQNQLEESLKS-- 503
QL + + Q Q + LE L + N+L+E ++
Sbjct: 2457 AQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLR 2516
Query: 504 --QELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEAL 561
+ L S+N +L + +++ + +I + + +LE + Q + E+ +LEE L
Sbjct: 2517 SHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKL 2576
Query: 562 VNVKSS-----------QFKLETAEKENQILGITLRQRDAEVTRLRE 597
+ + Q + + KE + L +++ Q +VT L+E
Sbjct: 2577 KESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQE 2623
Score = 31.2 bits (69), Expect = 4.6
Identities = 52/238 (21%), Positives = 88/238 (36%), Gaps = 32/238 (13%)
Query: 393 IKYLLGELKALVAEQEDSEI--QRLITEMEACISVLPTVSGNTDIQVEIAL--------- 441
I +L +L+ AE+ D E+ Q+ + +ME G I++++ L
Sbjct: 573 IAFLKLQLQGKRAEEADHEVLDQKEMKQMEG--------EGIAPIKMKVFLEDTGQDFPL 624
Query: 442 ------AMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQN 495
++ + E A Q R + + S D + L ++ + Q+
Sbjct: 625 MPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQD 684
Query: 496 QLEESLKSQEL-LQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIK 554
+LE LKSQ L L+ + ++ E DE K S + +N T +
Sbjct: 685 ELER-LKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALS 743
Query: 555 IELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSD 612
E ++ L VK E + Q L AE R R L QT+ LL++
Sbjct: 744 EERDQLLSQVKELSMVTELRAQVKQ-----LEMNLAEAERQRRLDYESQTAHDNLLTE 796
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 61.2 bits (147), Expect = 4e-09
Identities = 84/351 (23%), Positives = 158/351 (45%), Gaps = 52/351 (14%)
Query: 302 KETDLLKCIQTYLSLFRSHGKET---HLDSQTHRSPTQSQPAFL--ATNEEKCAREQIRE 356
KE + +C+ T L + K+ + + ++ Q L A +E+ A +Q +
Sbjct: 284 KELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQ 343
Query: 357 ATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKAL-----VAEQEDSE 411
E H+ DT+ + +QK ++K +K I+ L EL+ L +AE+E +
Sbjct: 344 CKEEAALAGCHLEDTQ--RKLQKGLLLDK--QKADTIQELQRELQMLQKESSMAEKEQTS 399
Query: 412 IQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQ 471
++ + E+ +S N+D E + + ++ ++ L + Q REQ
Sbjct: 400 NRKRVEELSLELSEALRKLENSD--KEKRQLQKTVAEQDMKMNDMLDRIKHQHREQ---- 453
Query: 472 KPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQK---DENKKF 528
G++ C LE E+ ++ +LL+ K E+L K E++K E +
Sbjct: 454 ---GSIKCKLE---------------EDLQEATKLLEDKREQLKKSKEHEKLMEGELEAL 495
Query: 529 SSIFKDKDQTILENKQQYDIEITRIKIE-------LEEALVNVKSSQFKLETAEKENQIL 581
FK KD+T+ EN ++ + E ++ E LE +L +SQ ++ KE +
Sbjct: 496 RQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQ 555
Query: 582 GITLRQRDAEVTR-LRELTRTLQTSMAKLLSD-LSVDSARCKPGNNLTKSL 630
+L A++ + L++ LQT++ K D LS SA C+ ++LT++L
Sbjct: 556 KESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQ--DDLTQAL 604
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
a [Homo sapiens]
Length = 1007
Score = 61.2 bits (147), Expect = 4e-09
Identities = 84/351 (23%), Positives = 158/351 (45%), Gaps = 52/351 (14%)
Query: 302 KETDLLKCIQTYLSLFRSHGKET---HLDSQTHRSPTQSQPAFL--ATNEEKCAREQIRE 356
KE + +C+ T L + K+ + + ++ Q L A +E+ A +Q +
Sbjct: 429 KELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQ 488
Query: 357 ATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKAL-----VAEQEDSE 411
E H+ DT+ + +QK ++K +K I+ L EL+ L +AE+E +
Sbjct: 489 CKEEAALAGCHLEDTQ--RKLQKGLLLDK--QKADTIQELQRELQMLQKESSMAEKEQTS 544
Query: 412 IQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQ 471
++ + E+ +S N+D E + + ++ ++ L + Q REQ
Sbjct: 545 NRKRVEELSLELSEALRKLENSD--KEKRQLQKTVAEQDMKMNDMLDRIKHQHREQ---- 598
Query: 472 KPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQK---DENKKF 528
G++ C LE E+ ++ +LL+ K E+L K E++K E +
Sbjct: 599 ---GSIKCKLE---------------EDLQEATKLLEDKREQLKKSKEHEKLMEGELEAL 640
Query: 529 SSIFKDKDQTILENKQQYDIEITRIKIE-------LEEALVNVKSSQFKLETAEKENQIL 581
FK KD+T+ EN ++ + E ++ E LE +L +SQ ++ KE +
Sbjct: 641 RQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQ 700
Query: 582 GITLRQRDAEVTR-LRELTRTLQTSMAKLLSD-LSVDSARCKPGNNLTKSL 630
+L A++ + L++ LQT++ K D LS SA C+ ++LT++L
Sbjct: 701 KESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQ--DDLTQAL 749
Score = 33.5 bits (75), Expect = 0.93
Identities = 48/209 (22%), Positives = 88/209 (42%), Gaps = 33/209 (15%)
Query: 350 AREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQED 409
A E++ TSE K L + T+ K Q + + E++ K L EL+ L ++
Sbjct: 748 ALEKLNHVTSETKSLQQSLTQTQE-KKAQLEEEIIAYEERM---KKLNTELRKLRGFHQE 803
Query: 410 SEIQ-----RLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQL 464
SE++ + + EM +C + D+++ +A + LR + + ++ L + L
Sbjct: 804 SELEVHAFDKKLEEM-SCQVLQWQKQHQNDLKM-LAAKEEQLR----EFQEEMAALKENL 857
Query: 465 REQQKTQ----------------KPSGAVDCNLELFSLQS--LNMSLQNQLEESLKSQEL 506
E K + + + NLE ++ Q N L NQL E +K
Sbjct: 858 LEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAK 917
Query: 507 LQSKNEELLKVIENQKDENKKFSSIFKDK 535
L + + L V+ + + ENKK ++K
Sbjct: 918 LSGEKDHLHSVMVHLQQENKKLKKEIEEK 946
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 60.1 bits (144), Expect = 9e-09
Identities = 126/642 (19%), Positives = 249/642 (38%), Gaps = 90/642 (14%)
Query: 276 KTDISAIPTLQQLGLVNGILPQQGIHKETDLLKC------IQTYLSLFRSHGKETH-LDS 328
++ ISA ++ + N IL + + L K I+ L ++ G+ L++
Sbjct: 573 RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN 632
Query: 329 QTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAE 388
+ H +++ K E+I E +L ++ + + KT +
Sbjct: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELE------------RENRKLKKTLD 680
Query: 389 KVRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRS 448
+ + + L L E+E+S++ E+ + L S ++ L + L S
Sbjct: 681 SFKNLTFQLESL-----EKENSQLDEENLELRRNVESLKCASMK---MAQLQLENKELES 732
Query: 449 ENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELF--SLQSLNMSLQNQLEESLKSQEL 506
E QL++ L +L ++ ++ + +D + +L++ N +Q QLE L+ E+
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ-QLESELQDLEM 791
Query: 507 LQS---KNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVN 563
KN E LK+ + ++ +K + + + + ++K+Q + E R++ + E
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 564 VKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQ----------TSMAKLLSDL 613
++ + K+ EKEN+ L + RL+EL + + ++ L DL
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL 911
Query: 614 SVDSARCKPGNN----LTKSL--LNIHDKQLQHDPAPAHTSIMSYL-NKLE--------- 657
+ + + NN LT L + ++ ++L HD S L +KLE
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEI 971
Query: 658 ---------------TNYSFTHSEPLSTI-KNEETIEPDKTYENVLSSRGPQNSNTRGME 701
TNY+ + L T+ KN E ++ + E ++ S P + E
Sbjct: 972 KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE 1031
Query: 702 EASAPGIISALSKQDSDEGSETMALIEDEHNLDNTIYIPFARSTPEKKSPLSKRLSPQPQ 761
S L +D LIE E N + T+ + K ++ + Q Q
Sbjct: 1032 RESQETTRELLKVKD--------RLIEVERN-NATLQAEKQALKTQLKQLETQNNNLQAQ 1082
Query: 762 IRAATTQLVS----NSGLAVSGKENKLCTPVICSSSTKEAEDAPEKLSRASDM--KDTQL 815
I A Q VS N+ L + ++ + S ST + L + S + ++ +
Sbjct: 1083 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV 1142
Query: 816 LKKIKEAIGKIPAATKEPEEQTACHGPSGCLSNSLQVKGNTV 857
+K+ ++ + K+ E+ H SL K T+
Sbjct: 1143 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1184
Score = 42.4 bits (98), Expect = 0.002
Identities = 114/517 (22%), Positives = 209/517 (40%), Gaps = 70/517 (13%)
Query: 372 KTVKDVQKAKNVNKTAEKVR-IIKYLLGELKALVAEQED-SEIQRLITEMEACISVLPTV 429
+ V D+Q + + + E + ++K + LK L+ E+++ SE ++E + LP
Sbjct: 168 ENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHA 227
Query: 430 SGNTDIQ-----VEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCN---- 480
S + ++ + Q L E A + ++R L Q+L E K +DC
Sbjct: 228 SSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEE-----KTEQLLDCKQELE 282
Query: 481 ---LELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKD- 536
+EL LQ NM+L + + ++ L + E+ ++V + + E ++ D +
Sbjct: 283 QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV-DKLESEVSRYKERLHDIEF 341
Query: 537 -QTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLR----QRDAE 591
+ +E ++ + + K LE+ L ++ KL EKEN L L +RD +
Sbjct: 342 YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMD 401
Query: 592 VTRLRELTRTLQT-SMAKLLS-DLSVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSI 649
++ EL T MA+ S D S+ + T L K L H+ +S
Sbjct: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR 461
Query: 650 MSYLNKLETNYSFTHSEPLSTIKNEE-----TIEPDKTYENVLSSRGPQNSNTRGMEEAS 704
+ L + + T E +T+ + E ++ +K EN S+ + ++E
Sbjct: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK--ENQRLSKKVEILENEIVQEKQ 519
Query: 705 APGIISALSKQDSDEGSETMALIED-EHNLDNTIYIPFARSTPEKKSPLSKRLSPQPQIR 763
+ LSK E ++ IE N + I I ++ L++ +S Q
Sbjct: 520 SLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI-----LEQENEHLNQTVSSLRQ-- 572
Query: 764 AATTQLVSNSGLAVSGKENKLCTPVICSSST-------------KEAEDAPEKLSRASDM 810
+Q+ + + + KENK+ I +S+ KE E EK RA ++
Sbjct: 573 --RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
Query: 811 --------KDTQLLKK----IKEAIGKIPAATKEPEE 835
K+ +LL+K +K KI A +E E
Sbjct: 631 ENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 60.1 bits (144), Expect = 9e-09
Identities = 124/641 (19%), Positives = 247/641 (38%), Gaps = 89/641 (13%)
Query: 276 KTDISAIPTLQQLGLVNGILPQQGIHKETDLLKC------IQTYLSLFRSHGKETH-LDS 328
++ ISA ++ + N IL + + L K I+ L ++ G+ L++
Sbjct: 573 RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN 632
Query: 329 QTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAE 388
+ H +++ K E+I E +L ++ + + KT +
Sbjct: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELE------------RENRKLKKTLD 680
Query: 389 KVRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRS 448
+ + + L L E+E+S++ E+ + L S ++ L + L S
Sbjct: 681 SFKNLTFQLESL-----EKENSQLDEENLELRRNVESLKCASMK---MAQLQLENKELES 732
Query: 449 ENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELF--SLQSLNMSLQNQLEESLKSQEL 506
E QL++ L +L ++ ++ + +D + +L++ N +Q QLE L+ E+
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ-QLESELQDLEM 791
Query: 507 LQS---KNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVN 563
KN E LK+ + ++ +K + + + + ++K+Q + E R++ + E
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 564 VKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQ----------TSMAKLLSDL 613
++ + K+ EKEN+ L + RL+EL + + ++ L DL
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL 911
Query: 614 SVDSARCKPGNN----LTKSL--LNIHDKQLQHDPAPAHTSIMSYLNKLE---------- 657
+ + + NN LT L + ++ ++L HD +KLE
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIK 971
Query: 658 --------------TNYSFTHSEPLSTI-KNEETIEPDKTYENVLSSRGPQNSNTRGMEE 702
TNY+ + L T+ KN E ++ + E ++ S P + E
Sbjct: 972 EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1031
Query: 703 ASAPGIISALSKQDSDEGSETMALIEDEHNLDNTIYIPFARSTPEKKSPLSKRLSPQPQI 762
S L +D LIE E N + T+ + K ++ + Q QI
Sbjct: 1032 ESQETTRELLKVKD--------RLIEVERN-NATLQAEKQALKTQLKQLETQNNNLQAQI 1082
Query: 763 RAATTQLVS----NSGLAVSGKENKLCTPVICSSSTKEAEDAPEKLSRASDM--KDTQLL 816
A Q VS N+ L + ++ + S ST + L + S + ++ ++
Sbjct: 1083 LALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI 1142
Query: 817 KKIKEAIGKIPAATKEPEEQTACHGPSGCLSNSLQVKGNTV 857
K+ ++ + K+ E+ H SL K T+
Sbjct: 1143 KEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1183
Score = 42.4 bits (98), Expect = 0.002
Identities = 114/517 (22%), Positives = 209/517 (40%), Gaps = 70/517 (13%)
Query: 372 KTVKDVQKAKNVNKTAEKVR-IIKYLLGELKALVAEQED-SEIQRLITEMEACISVLPTV 429
+ V D+Q + + + E + ++K + LK L+ E+++ SE ++E + LP
Sbjct: 168 ENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHA 227
Query: 430 SGNTDIQ-----VEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCN---- 480
S + ++ + Q L E A + ++R L Q+L E K +DC
Sbjct: 228 SSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEE-----KTEQLLDCKQELE 282
Query: 481 ---LELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKD- 536
+EL LQ NM+L + + ++ L + E+ ++V + + E ++ D +
Sbjct: 283 QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV-DKLESEVSRYKERLHDIEF 341
Query: 537 -QTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLR----QRDAE 591
+ +E ++ + + K LE+ L ++ KL EKEN L L +RD +
Sbjct: 342 YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMD 401
Query: 592 VTRLRELTRTLQT-SMAKLLS-DLSVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSI 649
++ EL T MA+ S D S+ + T L K L H+ +S
Sbjct: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR 461
Query: 650 MSYLNKLETNYSFTHSEPLSTIKNEE-----TIEPDKTYENVLSSRGPQNSNTRGMEEAS 704
+ L + + T E +T+ + E ++ +K EN S+ + ++E
Sbjct: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK--ENQRLSKKVEILENEIVQEKQ 519
Query: 705 APGIISALSKQDSDEGSETMALIED-EHNLDNTIYIPFARSTPEKKSPLSKRLSPQPQIR 763
+ LSK E ++ IE N + I I ++ L++ +S Q
Sbjct: 520 SLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI-----LEQENEHLNQTVSSLRQ-- 572
Query: 764 AATTQLVSNSGLAVSGKENKLCTPVICSSST-------------KEAEDAPEKLSRASDM 810
+Q+ + + + KENK+ I +S+ KE E EK RA ++
Sbjct: 573 --RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
Query: 811 --------KDTQLLKK----IKEAIGKIPAATKEPEE 835
K+ +LL+K +K KI A +E E
Sbjct: 631 ENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 57.4 bits (137), Expect = 6e-08
Identities = 105/485 (21%), Positives = 211/485 (43%), Gaps = 74/485 (15%)
Query: 226 RPPCPPKVHSEVQTDGN------------SQFASQGKTVSATCTDVLRNSFN-TSP--GV 270
RPP P ++T+G+ +Q + + +AT T +L+N TSP G
Sbjct: 460 RPPQPNIDGKVLETEGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGA 519
Query: 271 PCSLPKTDISAIPTLQQLGLVNGILPQQGIHKETDLLKCIQTYLSLFRSHGKE--THLDS 328
KT SA T L+ G QQ + ++T+ +T + ++ KE T D
Sbjct: 520 KKISVKTFPSASNTQATPDLLKG---QQELTQQTNE----ETAKQILYNYLKEGSTDNDD 572
Query: 329 QTHRSPT---------QSQPAFLAT-NEEKC-AREQIREATSERKDLNIHVRDTKTVK-- 375
T R +S+ A A N + C + ++++ ++ L I V + +
Sbjct: 573 ATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQL 632
Query: 376 DVQKAKNVNKTAEKVRIIKYLLGELKALVAE--QEDSEIQRLITEMEACISVLPTVSGNT 433
+V+ +N+ + E++R L EL++ E +E+S +Q+ + E E + N
Sbjct: 633 EVKNQQNIKEERERMRAN---LEELRSQHNEKVEENSTLQQRLEESEG------ELRKNL 683
Query: 434 DIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQ-KPSGAVDCNLELFSLQSLNMS 492
+ ++ + + ++E L+ QL ++ +L ++++ + GA+ + L
Sbjct: 684 EELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGAL-----IEELLQAKQD 738
Query: 493 LQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITR 552
LQ+ L + ++LL+ + EL + K+E DQ + + K+QYD E+
Sbjct: 739 LQDLLIAKEEQEDLLRKRERELTALKGALKEE-------VSSHDQEMDKLKEQYDAELQA 791
Query: 553 IKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKL--- 609
++ +EEA NV+ + T+E++ + ++ E +L+ + L+ +A+L
Sbjct: 792 LRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQ 851
Query: 610 LSDLSVDSARCKPG--------NNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLETNYS 661
+ DL D A+ K L ++L +H ++ + + A ++ + L + N S
Sbjct: 852 IEDLKGDEAKAKETLKKYEGEIRQLEEAL--VHARKEEKEAVSARRALENELEAAQGNLS 909
Query: 662 FTHSE 666
T E
Sbjct: 910 QTTQE 914
Score = 32.0 bits (71), Expect = 2.7
Identities = 46/220 (20%), Positives = 93/220 (42%), Gaps = 24/220 (10%)
Query: 323 ETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKN 382
E L+ + + S S+ + + + R ++ + + R+DL + K++
Sbjct: 1074 EMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRI 1133
Query: 383 VNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALA 442
++ + L+ +++A +AE ED RL +E E + L + + +V+ L
Sbjct: 1134 IHLEGSYRSSKEGLVVQMEARIAELED----RLESE-ERDRANLQLSNRRLERKVK-ELV 1187
Query: 443 MQ------PLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQ 496
MQ L + QL +L+ + +Q+ E ++ E+ L+S LQ +
Sbjct: 1188 MQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEE------------EIDRLESSKKKLQRE 1235
Query: 497 LEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKD 536
LEE + E LQ + + K + +K +K + D D
Sbjct: 1236 LEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDDDD 1275
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 55.1 bits (131), Expect = 3e-07
Identities = 66/274 (24%), Positives = 124/274 (45%), Gaps = 40/274 (14%)
Query: 352 EQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDSE 411
E++R T ER DL V +T V+ Q +N+ +T I + L + + + E
Sbjct: 1679 EEMRSVTKERDDLR-SVEETLKVERDQLKENLRET-----ITRDLEKQEELKIVHMHLKE 1732
Query: 412 IQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKT- 470
Q I ++ +S N +Q ++ + L++++ +++ +LRI + L+EQQ+T
Sbjct: 1733 HQETIDKLRGIVSEKTNEISN--MQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETI 1790
Query: 471 QKPSGAVDCNLELFS-----LQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDEN 525
K G V + S L++ N LQ +++E L++ +L+ + ++ +
Sbjct: 1791 DKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQE-------LKANEHQLITLKKDVNETQ 1843
Query: 526 KKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITL 585
KK S + + K KQ D +T K+E+E N+ +Q E E+ + +
Sbjct: 1844 KKVSEMEQLK-------KQIKDQSLTLSKLEIE----NLNLAQKLHENLEEMKSV----M 1888
Query: 586 RQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSAR 619
++RD LR + TL+ +L L AR
Sbjct: 1889 KERD----NLRRVEETLKLERDQLKESLQETKAR 1918
Score = 46.2 bits (108), Expect = 1e-04
Identities = 71/349 (20%), Positives = 146/349 (41%), Gaps = 45/349 (12%)
Query: 298 QGIHKETDLLKCIQTYLSLFRSH--GKETHLDSQTHRSPTQSQPAFLATNEEKCAREQIR 355
+ I KE +LK +Q R H G +++ ++ + + A + E + +++R
Sbjct: 1196 KSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELR 1255
Query: 356 EATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRL 415
+ SE+ I+ +D + K+ K E++ ++ E + L +E SE Q
Sbjct: 1256 RSVSEKTAQIINTQDLE--------KSHTKLQEEIPVLHE---EQELLPNVKEVSETQET 1304
Query: 416 ITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSG 475
+ E+E T T ++E M+ LR LN++ +E Q+ K
Sbjct: 1305 MNELELLTEQSTTKDSTTLARIE----MERLR------------LNEKFQESQEEIK--- 1345
Query: 476 AVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDK 535
E +L+++ +L+ +K +L + E L K+ E+Q + + + KD
Sbjct: 1346 --SLTKERDNLKTIKEALE------VKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDN 1397
Query: 536 DQT-ILENKQQY---DIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAE 591
+ T I+ +Q+ D + RI+IE+ ++ S ++++ KE L +E
Sbjct: 1398 ETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSE 1457
Query: 592 VTRLRELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKSL-LNIHDKQLQ 639
+L+E + + + +L V K L +N+ +K+ +
Sbjct: 1458 SDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETE 1506
Score = 42.7 bits (99), Expect = 0.002
Identities = 121/600 (20%), Positives = 240/600 (40%), Gaps = 101/600 (16%)
Query: 291 VNGILPQQGIHKETDLLKCIQTYLSLFRSHGKETHLDSQTHRSPTQSQPAFLATNEEKCA 350
V G+L + G K+ + T S ++S +E H Q L NE
Sbjct: 791 VQGLLEEIGKTKDD-----LATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERM-- 843
Query: 351 REQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQE-- 408
++I + E + + + KT + + + EK R ++ L E++ L + E
Sbjct: 844 NQEIVNLSKEAQKFDSSLGALKT----ELSYKTQELQEKTREVQERLNEMEQLKEQLENR 899
Query: 409 DSEIQRLITEM----EACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLR-ILNQQ 463
DS +Q + E E L V T + ++ + L+ E QL+ + +N
Sbjct: 900 DSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMN 959
Query: 464 LREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEE----LLKVIE 519
+ Q++ + ++ + E ++ +L + ++ +L +E +E ++ + +
Sbjct: 960 IDTQEQLRNALESLKQHQE--TINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDK 1017
Query: 520 NQKDENKKFSSIFKD-KDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKEN 578
Q E K ++ D KD I+E +++ + + K EL++ L +V + + +L+T KEN
Sbjct: 1018 KQDLEAKNTQTLTADVKDNEIIEQQRKI-FSLIQEKNELQQMLESVIAEKEQLKTDLKEN 1076
Query: 579 -----------QILGITLR--------------QRDAEVTR-----------LRELTRTL 602
++LG L+ +++ E++R L+E ++ L
Sbjct: 1077 IEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQL 1136
Query: 603 QTSMAKLLS---DLSVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLETN 659
Q +LL+ ++S + NL L N + L+H T + KL N
Sbjct: 1137 QEKQQQLLNVQEEMSEMQKKINEIENLKNELKN-KELTLEH----METERLELAQKLNEN 1191
Query: 660 YSFTHSEPLSTIKNEETI--EPDKTYENVLSSRGPQNSNTRG-MEEASAPGIISALSKQD 716
Y E + +I E + E K++E + + RG + E A G+ +
Sbjct: 1192 Y-----EEVKSITKERKVLKELQKSFET-------ERDHLRGYIREIEATGL-----QTK 1234
Query: 717 SDEGSETMALIEDEHNLDNTIYIPFARSTPEKKSPLSKRLSPQPQIRAATTQLVSNSGLA 776
+ + L E + +D RS EK + ++ + + T+L +
Sbjct: 1235 EELKIAHIHLKEHQETIDE-----LRRSVSEK----TAQIINTQDLEKSHTKL--QEEIP 1283
Query: 777 VSGKENKLCTPVICSSSTKEAEDAPEKLSRASDMKDTQLLKKIKEAIGKIPAATKEPEEQ 836
V +E +L V S T+E + E L+ S KD+ L +I+ ++ +E +E+
Sbjct: 1284 VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEE 1343
Score = 42.0 bits (97), Expect = 0.003
Identities = 56/275 (20%), Positives = 130/275 (47%), Gaps = 24/275 (8%)
Query: 352 EQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVR--IIKYLLGELKALVAEQED 409
++++E+ E K + D + +++V ++++ ++ E ++ + K+L E + VA
Sbjct: 1428 KRLQESHDEMKSVAKEKDDLQRLQEVLQSES-DQLKENIKEIVAKHLETEEELKVAHCCL 1486
Query: 410 SEIQRLITEMEACISVLPTVSGNTDIQVE-----IALAMQPLRSENAQLR-RQLRILNQQ 463
E + I E+ +S T Q+E + +Q + + Q +Q+ + ++
Sbjct: 1487 KEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEK 1546
Query: 464 LREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIE---- 519
+ E ++ ++ A D L+ S++S + L N+L+ES + +++ + EE+ +V E
Sbjct: 1547 VNELKQFKEHRKAKDSALQ--SIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQI 1604
Query: 520 ---NQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKI-ELEEALVNVKSSQFKLETAE 575
K+ K+ + K+ + + + + T+ K+ E+E ++ + LE E
Sbjct: 1605 ERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIE 1664
Query: 576 KEN----QILGITLRQRDAEVTRLRELTRTLQTSM 606
EN QIL L + VT+ R+ R+++ ++
Sbjct: 1665 TENIRLTQILHENLEEM-RSVTKERDDLRSVEETL 1698
Score = 41.6 bits (96), Expect = 0.003
Identities = 41/205 (20%), Positives = 99/205 (48%), Gaps = 33/205 (16%)
Query: 348 KCAREQIREATSERKDLNIHVR-DTKTVKDVQKA--KNVNKTAEKVRIIKYLLGELKALV 404
K R+Q++E+ E K ++ ++ + KT + + K + V+K EK+ + +++ +
Sbjct: 1902 KLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDL 1961
Query: 405 AEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQL 464
+ +D E+Q+ I E++ +Q LR ++ + + ++++
Sbjct: 1962 DKSKD-ELQKKIQELQK-------------------KELQLLR-----VKEDVNMSHKKI 1996
Query: 465 REQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDE 524
E ++ +K A NL + S++ N L +L ESL+ ++ + +EL ++ E+ K E
Sbjct: 1997 NEMEQLKKQFEAQ--NLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKME 2054
Query: 525 NKKFSSIFKDKDQTILENKQQYDIE 549
+F + + + I ++Q + ++
Sbjct: 2055 RDQFIATLR---EMIARDRQNHQVK 2076
Score = 40.8 bits (94), Expect = 0.006
Identities = 105/530 (19%), Positives = 204/530 (38%), Gaps = 99/530 (18%)
Query: 381 KNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQV--- 437
K +++ EKV +K KA +DS +Q + ++M + L I +
Sbjct: 1538 KQISEVQEKVNELKQFKEHRKA-----KDSALQSIESKMLELTNRLQESQEEIQIMIKEK 1592
Query: 438 -EIALAMQPLRSENAQLRRQLRILNQQLREQQK-------------TQKPSGAVDCNLEL 483
E+ + L+ E QL+ + + +++E Q+ TQ+ ++ E
Sbjct: 1593 EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQ 1652
Query: 484 FSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQ------ 537
F Q LN L+N E+++ ++L EE+ V + + D ++ ++DQ
Sbjct: 1653 FETQKLN--LENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLR 1710
Query: 538 -TI---LENKQQYDI------------------------EITRIKIELEEALVNVKSSQF 569
TI LE +++ I EI+ ++ +LE + +K+
Sbjct: 1711 ETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDL 1770
Query: 570 KLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKS 629
K+ ++E +I + L+++ + +LR + ++ + DL +++ K + +
Sbjct: 1771 KI---QEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDL--ENSNAKLQEKIQEL 1825
Query: 630 LLNIHDK-QLQHD--PAPAHTSIMSYLNKLETNYSFTHSEPLSTIKNEETIEPDKTYENV 686
N H L+ D S M L K + S T LS ++ E K +EN+
Sbjct: 1826 KANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLT----LSKLEIENLNLAQKLHENL 1881
Query: 687 --LSSRGPQNSNTRGMEEA------SAPGIISALSKQDSDEGSE--TMALIEDEHN---- 732
+ S + N R +EE + +D + E T ++ EH
Sbjct: 1882 EEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVD 1941
Query: 733 ------LDNTIYI-PFARSTPEKKSPLSKRLSPQPQIRAATTQLVSNSGLAVSGKENKLC 785
+ TI I + + K L K++ +++ QL L V N
Sbjct: 1942 KLREKISEKTIQISDIQKDLDKSKDELQKKIQ---ELQKKELQL-----LRVKEDVNMSH 1993
Query: 786 TPVICSSSTKEAEDAPEKLSRASDMKDTQLLKKIKEAIGKIPAATKEPEE 835
+ K+ +A ++ M + QL KK+ E++ +I KE +E
Sbjct: 1994 KKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDE 2043
Score = 34.3 bits (77), Expect = 0.54
Identities = 99/563 (17%), Positives = 222/563 (39%), Gaps = 75/563 (13%)
Query: 322 KETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAK 381
K+T D++T + + AFL + E +E+++E + K + ++ ++ + +K
Sbjct: 624 KQTLFDAETVALDAKRESAFLRS-ENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKM 682
Query: 382 NVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIAL 441
V+ E ++ E+ L + + + L+ +E + TD+Q E+
Sbjct: 683 QVDLEKE----LQSAFNEITKLTSLIDGKVPKDLLCNLELEGKI-------TDLQKELNK 731
Query: 442 AMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAV-DCNLELFSLQSLNMSLQNQLEES 500
++ EN LR ++ +L++ + ++ + D + EL + S L +++
Sbjct: 732 EVE----ENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHK 787
Query: 501 LKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQ-----------------TILENK 543
+S+ + LL+ I KD+ S +K DQ +LE
Sbjct: 788 -------ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN 840
Query: 544 QQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQ 603
++ + EI + E ++ ++ + + +L +E Q +++R E+ +L+E
Sbjct: 841 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
Query: 604 TSMAKLLSDLSVDSARCKPGNNLTKSLLNIHD--KQLQ--------------HDPAPAHT 647
+++ + + ++ + + + K+L D KQLQ HD +
Sbjct: 901 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI 960
Query: 648 SIMSYL-NKLETNYSFTHSEPLSTIKNEETIEPDKTY---ENVLSSRGPQNSNTRGME-- 701
L N LE+ H E ++T+K++ + E + EN ++ G++
Sbjct: 961 DTQEQLRNALESLKQ--HQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKK 1018
Query: 702 ---EASAPGIISALSKQDS--DEGSETMALIEDEHNLDNTIYIPFARSTPEK---KSPLS 753
EA ++A K + ++ + +LI++++ L + A K K +
Sbjct: 1019 QDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIE 1078
Query: 754 KRLSPQPQIRAATTQLVSNSGLAVSGKENKLCTPVICSSSTKEAEDAPEKLSRASD--MK 811
+ Q ++R +L + K + + S + + EKL S +
Sbjct: 1079 MTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQE 1138
Query: 812 DTQLLKKIKEAIGKIPAATKEPE 834
Q L ++E + ++ E E
Sbjct: 1139 KQQQLLNVQEEMSEMQKKINEIE 1161
Score = 32.3 bits (72), Expect = 2.1
Identities = 43/191 (22%), Positives = 87/191 (45%), Gaps = 29/191 (15%)
Query: 439 IALAMQPLRSENAQLRRQLRILNQ--QLREQQKTQKPSGAVDCNLELFSLQSL------- 489
+ L + LR+E ++ +L+ N + ++ K + E+ +L++L
Sbjct: 510 LVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVY 569
Query: 490 NMSLQNQLEESLKSQELLQSKNEELLKV---IENQKDENKKFSSIFKDKDQTILENKQQ- 545
N L+N+L + ELL+ K +++ K+ I++QK EN K + ++I + KQ
Sbjct: 570 NQDLENELSSKV---ELLREKEDQIKKLQEYIDSQKLENIKMDLSY--SLESIEDPKQMK 624
Query: 546 ---YDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLR---ELT 599
+D E + + E A ++S +L+ KE L T +Q + ++ + E
Sbjct: 625 QTLFDAETVALDAKRESAF--LRSENLELKEKMKE---LATTYKQMENDIQLYQSQLEAK 679
Query: 600 RTLQTSMAKLL 610
+ +Q + K L
Sbjct: 680 KKMQVDLEKEL 690
>gi|224586823 coiled-coil domain containing 110 isoform b [Homo
sapiens]
Length = 796
Score = 53.9 bits (128), Expect = 7e-07
Identities = 83/376 (22%), Positives = 153/376 (40%), Gaps = 43/376 (11%)
Query: 381 KNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIA 440
KN+ R+ +Y L L E +D E Q + + + IS S + +
Sbjct: 329 KNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCV 388
Query: 441 LAMQPLRS---ENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSL---Q 494
+Q L++ E+ Q+++++ L + + KP +F+ QSL + +
Sbjct: 389 AKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPL--------IFTTQSLIQKVETYE 440
Query: 495 NQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENK--QQYDIEITR 552
QL+ ++ + +QSK L K E K+ K+F I + +NK ++ +I+++
Sbjct: 441 KQLKNLVEEKSTIQSK---LSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL 497
Query: 553 IKIELEEALVNVKSSQFKLET----AEKENQILGITLRQRDAEVTRLRELTRTLQTSMAK 608
K ++ EAL +KS + K ++ EN + I + + +++ L+ +
Sbjct: 498 EKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQ 557
Query: 609 LLSDLSVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLET------NYSF 662
LL + S GN L +S L I QL+ A T + L +ET N
Sbjct: 558 LLKEKS------SLGNELKESQLEI--IQLKEKERLAKTEQETLLQIIETVKDEKLNLET 609
Query: 663 THSEPLSTIK-NEETIEPDKTYENVLSSRGPQNSNTRGMEEASAPGIISALSKQDSDEGS 721
T E + + E IE +TY++ Q E + +S + K+
Sbjct: 610 TLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKE-----C 664
Query: 722 ETMALIEDEHNLDNTI 737
E ++ + E DN I
Sbjct: 665 EMLSKMVMETKTDNQI 680
Score = 35.0 bits (79), Expect = 0.32
Identities = 71/358 (19%), Positives = 144/358 (40%), Gaps = 81/358 (22%)
Query: 347 EKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAE 406
E+ ++E ++E N+ KT+++ KN+ + EK ++++ L +LK+ +
Sbjct: 461 EEYSKECLKEFKKIISKYNVLQGQNKTLEE----KNIQLSLEKQQMME-ALDQLKSKEHK 515
Query: 407 QE------DSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRIL 460
+ ++E R+ EMEA + + + ++ L + QL ++ L
Sbjct: 516 TQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM----------LEKKTHQLLKEKSSL 565
Query: 461 NQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIEN 520
+L+E Q LE+ L+ + + L +++ E LL++IE
Sbjct: 566 GNELKESQ------------LEIIQLK--------------EKERLAKTEQETLLQIIET 599
Query: 521 QKDENKKFSSIFKDKD------QTILENKQQYDIE-----ITRIKIELEEALVNVKS--- 566
KDE + ++ + +EN Q Y + IK EA + S
Sbjct: 600 VKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSE 659
Query: 567 --------SQFKLETAEKENQILGITLRQRDAE-------VTRLRELTRTLQTSMAKLLS 611
S+ +ET + +NQIL L++ E ++RL E L+ + + +
Sbjct: 660 IGKECEMLSKMVMET-KTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIEN 718
Query: 612 DLSVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLETNYSFTHSEPLS 669
+ + +L + L++ DK P+ T+ +S K + ++TH + S
Sbjct: 719 ERDTLEFEMR---HLQREYLSLSDKICNQHNDPSKTTYISRREKFHFD-NYTHEDTSS 772
>gi|22749515 coiled-coil domain containing 110 isoform a [Homo
sapiens]
Length = 833
Score = 53.9 bits (128), Expect = 7e-07
Identities = 83/376 (22%), Positives = 153/376 (40%), Gaps = 43/376 (11%)
Query: 381 KNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIA 440
KN+ R+ +Y L L E +D E Q + + + IS S + +
Sbjct: 366 KNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCV 425
Query: 441 LAMQPLRS---ENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSL---Q 494
+Q L++ E+ Q+++++ L + + KP +F+ QSL + +
Sbjct: 426 AKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPL--------IFTTQSLIQKVETYE 477
Query: 495 NQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENK--QQYDIEITR 552
QL+ ++ + +QSK L K E K+ K+F I + +NK ++ +I+++
Sbjct: 478 KQLKNLVEEKSTIQSK---LSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL 534
Query: 553 IKIELEEALVNVKSSQFKLET----AEKENQILGITLRQRDAEVTRLRELTRTLQTSMAK 608
K ++ EAL +KS + K ++ EN + I + + +++ L+ +
Sbjct: 535 EKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQ 594
Query: 609 LLSDLSVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLET------NYSF 662
LL + S GN L +S L I QL+ A T + L +ET N
Sbjct: 595 LLKEKS------SLGNELKESQLEI--IQLKEKERLAKTEQETLLQIIETVKDEKLNLET 646
Query: 663 THSEPLSTIK-NEETIEPDKTYENVLSSRGPQNSNTRGMEEASAPGIISALSKQDSDEGS 721
T E + + E IE +TY++ Q E + +S + K+
Sbjct: 647 TLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKE-----C 701
Query: 722 ETMALIEDEHNLDNTI 737
E ++ + E DN I
Sbjct: 702 EMLSKMVMETKTDNQI 717
Score = 35.0 bits (79), Expect = 0.32
Identities = 71/358 (19%), Positives = 144/358 (40%), Gaps = 81/358 (22%)
Query: 347 EKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAE 406
E+ ++E ++E N+ KT+++ KN+ + EK ++++ L +LK+ +
Sbjct: 498 EEYSKECLKEFKKIISKYNVLQGQNKTLEE----KNIQLSLEKQQMME-ALDQLKSKEHK 552
Query: 407 QE------DSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRIL 460
+ ++E R+ EMEA + + + ++ L + QL ++ L
Sbjct: 553 TQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM----------LEKKTHQLLKEKSSL 602
Query: 461 NQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIEN 520
+L+E Q LE+ L+ + + L +++ E LL++IE
Sbjct: 603 GNELKESQ------------LEIIQLK--------------EKERLAKTEQETLLQIIET 636
Query: 521 QKDENKKFSSIFKDKD------QTILENKQQYDIE-----ITRIKIELEEALVNVKS--- 566
KDE + ++ + +EN Q Y + IK EA + S
Sbjct: 637 VKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSE 696
Query: 567 --------SQFKLETAEKENQILGITLRQRDAE-------VTRLRELTRTLQTSMAKLLS 611
S+ +ET + +NQIL L++ E ++RL E L+ + + +
Sbjct: 697 IGKECEMLSKMVMET-KTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIEN 755
Query: 612 DLSVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLETNYSFTHSEPLS 669
+ + +L + L++ DK P+ T+ +S K + ++TH + S
Sbjct: 756 ERDTLEFEMR---HLQREYLSLSDKICNQHNDPSKTTYISRREKFHFD-NYTHEDTSS 809
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 53.5 bits (127), Expect = 9e-07
Identities = 65/326 (19%), Positives = 131/326 (40%), Gaps = 41/326 (12%)
Query: 322 KETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSER-KDLNIHVRDTKTVKDVQK- 379
K +L+ + S + L K E ++ E + L + D T++ ++
Sbjct: 2155 KVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKEN 2214
Query: 380 -AKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQ----------RLITEMEACISVLPT 428
K + + ++ + LL K+L+ E+E +EIQ L +++ +
Sbjct: 2215 LTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAA 2274
Query: 429 VSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQS 488
+ G+ +I ++ P E QLR + L +L +K Q L LQ
Sbjct: 2275 LCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQ-----------LCVLQQ 2323
Query: 489 LNMS------LQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILEN 542
L S L+ ++E + E+ ++ E EN K E K K + + ++
Sbjct: 2324 LKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGE----VETLKAKIEGMTQS 2379
Query: 543 KQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRT- 601
+ ++++ I+ E E ++ Q ++ E N L++++ E +++E + T
Sbjct: 2380 LRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTA 2439
Query: 602 ---LQTSMAKL---LSDLSVDSARCK 621
LQT + +L ++ L D CK
Sbjct: 2440 MEMLQTQLKELNERVAALHNDQEACK 2465
Score = 50.8 bits (120), Expect = 6e-06
Identities = 122/520 (23%), Positives = 207/520 (39%), Gaps = 111/520 (21%)
Query: 329 QTHRSPTQSQPAFLATNEEKC-AREQIREATSERKDLNIHVRDTKTVKDVQKAKN----- 382
QT + A L ++E C A+EQ + E +L + ++ + +AKN
Sbjct: 2444 QTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELE----KAQLLQGLDEAKNNYIVL 2499
Query: 383 ---VNKTAEKVRIIKYLLGELKALVAEQEDSEIQRL---ITEMEACISVLPTVSGNTDIQ 436
VN ++V K L E++D EI RL I + E +S L V G +
Sbjct: 2500 QSSVNGLIQEVEDGKQKL--------EKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLW 2551
Query: 437 VEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQ 496
E +N +LR N + +QK Q LQS N SLQ+
Sbjct: 2552 KE----------QNLELR------NLTVELEQKIQV-------------LQSKNASLQDT 2582
Query: 497 LEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIE 556
L E+LQS + L +E K + F +E + + T ++ E
Sbjct: 2583 L-------EVLQSSYKNLENELELTKMDKMSF-----------VEKVNKMTAKETELQRE 2624
Query: 557 LEEALVNVKSSQFKLETAEKENQILG---ITLRQRDAEVTRLRELTRTLQTSMAKLLSDL 613
+ E + K+++ + E + ++N++ G + L + + +L+EL TL+ S K D
Sbjct: 2625 MHE--MAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKEL--TLENSELKKSLDC 2680
Query: 614 SVDSARCKPGNNLTKSLLNIHDKQLQ-HDPAPAHTSIMSYLNKLETNYSFTHSEPLSTIK 672
K G K I + QL+ H+ H +++ NK T+ E L++
Sbjct: 2681 MHKDQVEKEG----KVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTS-- 2734
Query: 673 NEETIEPDKTYENVLSSRGPQNSNTRGMEEASAPGIISALSKQDSDEGSETMALIEDEHN 732
EE + K ++L S + +N+ + I+ L K D L ++
Sbjct: 2735 KEECLSSQKLEIDLLKSSKEELNNSL----KATTQILEELKKTKMDNLKYVNQLKKENER 2790
Query: 733 LDN--TIYIPFARSTPEKKSPLSKRLSPQPQIRAATTQLVSNSGLAVSGKENKLCTPV-- 788
+ I + E+K L K LS Q++AA Q +G + K ++L T +
Sbjct: 2791 AQGKMKLLIKSCKQLEEEKEILQKELS---QLQAA--QEKQKTGTVMDTKVDELTTEIKE 2845
Query: 789 ---ICSSSTKEAED----------APEKLSRASDMKDTQL 815
TKEA++ + EKL +A +M +TQ+
Sbjct: 2846 LKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQV 2885
Score = 48.9 bits (115), Expect = 2e-05
Identities = 106/557 (19%), Positives = 219/557 (39%), Gaps = 102/557 (18%)
Query: 302 KETDLLKCIQTYLSLFRSHGKETHLDSQTHRSPTQSQ----PAFLATNEEKCAR--EQIR 355
KE + LK +T S ++S ++ ++ + QS+ L T + K E++R
Sbjct: 607 KEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVR 666
Query: 356 EATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRL 415
+R++L++ +R+ V D +K+V +K + Y+ + KA E D + Q+
Sbjct: 667 TLEMDRENLSVEIRNLHNVLD---SKSVEVETQK---LAYMELQQKA---EFSDQKHQKE 717
Query: 416 ITEMEACISVLPTVSGNTDIQVEIAL----------AMQPLRSENAQLRRQLRILNQQLR 465
I M C+ D++ ++ L Q L +E LR L+ + L
Sbjct: 718 IENM--CLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLV 775
Query: 466 EQQKTQKPSGAVD---------CNL--ELFSLQSLNMSLQNQLEESLKSQELLQSKNEEL 514
+ Q+ A D N+ E S+ S + + ++S K+ +LQ++ + L
Sbjct: 776 TNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSL 835
Query: 515 LKVIENQKDEN-------KKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSS 567
+E+QK N ++ I + ++ +++ +Q + + + + + +
Sbjct: 836 EFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAH 895
Query: 568 Q-------FKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARC 620
Q LE EKE Q+L + AE+ L++ L+ S+ +L
Sbjct: 896 QNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKEL----------- 944
Query: 621 KPGNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLETNYSFTHSEPLSTIKNEETIEPD 680
L L++ K++ +SI+S LNK E EE + +
Sbjct: 945 ----QLLSETLSLEKKEM--------SSIIS-LNKREI---------------EELTQEN 976
Query: 681 KTYENVLSSRGPQNSNTRGMEEASAPGIISALSKQDSDEGSETMALIEDEHNLDNTIYIP 740
T + + +S + N E+ A I DE ++++ + D++ + I +
Sbjct: 977 GTLKEINASLNQEKMNLIQKSESFANYI---------DEREKSISELSDQYKQEKLILLQ 1027
Query: 741 FARSTPEKKSPLSKRLSPQPQIRAATTQLVSNSGLAVSGKENKLCTPVICSSSTKEAEDA 800
T LS++ + + L++ ++N+L + + KE ++
Sbjct: 1028 RCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNEL--EQLKEAFAKEHQEF 1085
Query: 801 PEKLSRASDMKDTQLLK 817
KL+ A + +L+
Sbjct: 1086 LTKLAFAEERNQNLMLE 1102
Score = 43.5 bits (101), Expect = 9e-04
Identities = 96/415 (23%), Positives = 172/415 (41%), Gaps = 55/415 (13%)
Query: 349 CAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKAL--VAE 406
C E++ TSER L + DT + K + K EK + ++ E VAE
Sbjct: 1948 CLEEELSVVTSERNQLRGEL-DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAE 2006
Query: 407 QEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALA---MQPLRSENAQLRRQLRILNQQ 463
E E L+ + + +S L + T +Q ++ Q L +L Q+ LN
Sbjct: 2007 AEVKEKTELLQTLSSDVSEL--LKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLN-- 2062
Query: 464 LREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKD 523
+E++ K S ++ L + LN+S LE +L K E L++ Q++
Sbjct: 2063 -KEKELLVKESESLQARLSESDYEKLNVS--KALEAALVE------KGEFALRLSSTQEE 2113
Query: 524 ENKKFSSIFKDKDQTILENKQQYDI--EITRIKIELEEALVNVKSSQFKLETAEKENQIL 581
++ I K + + + K+Q I ++ + E + V++ + +L+ +E+ +++
Sbjct: 2114 VHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELV 2173
Query: 582 GITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKPGN-NLTKSLLNIHDKQLQH 640
+ AEV E +T MA+ L +D + NLTK I +KQ Q
Sbjct: 2174 ILDAENSKAEV----ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQ---IQEKQGQ- 2225
Query: 641 DPAPAHTSIMSYLNKLETNYSFTHSEPLSTIKNEETIEPDKTYENVLSSRGPQNSNTRGM 700
+S L+KL +++ S ++ +E E E+ + QN + +
Sbjct: 2226 ---------LSELDKLLSSFK-------SLLEEKEQAEIQIKEESKTAVEMLQNQ-LKEL 2268
Query: 701 EEASAPGIISALSKQDSDEGSETMAL---IEDEHNLDNTIYIPFARSTPEKKSPL 752
EA ++AL + +L IE+EH L N+I AR ++K L
Sbjct: 2269 NEA-----VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQL 2318
Score = 43.1 bits (100), Expect = 0.001
Identities = 73/382 (19%), Positives = 161/382 (42%), Gaps = 70/382 (18%)
Query: 322 KETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKA- 380
KE L S+T + + ++ N+ + E++ + K++N + K + +QK+
Sbjct: 942 KELQLLSETLSLEKKEMSSIISLNKREI--EELTQENGTLKEINASLNQEK-MNLIQKSE 998
Query: 381 ----------KNVNKTAEKVRIIKYLLGEL-------------KALVAEQEDSEIQRLIT 417
K++++ +++ + K +L + K A++++S+++ L+
Sbjct: 999 SFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLN 1058
Query: 418 EMEACISVLPTVSGNTDIQVEIALAMQP---------LRSENAQLRRQLRILNQQLREQQ 468
E C S+ + Q++ A A + N L +L + Q LR +
Sbjct: 1059 E---CTSLCENRKNELE-QLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEM 1114
Query: 469 KTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVI------ENQK 522
+ + + L+ M+L+ + + K L +NE+L+KV+ +N +
Sbjct: 1115 TDNQNNSKSEAG----GLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLE 1170
Query: 523 DENKKFSSIFKDKDQTILENKQQYDIEITRIKI-----ELEEALVNVKSSQFKLETAEKE 577
E + S ++ ++ K Q D+E+ I + +L + +++ + KL+ +EKE
Sbjct: 1171 SEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKE 1230
Query: 578 NQILGITLR--QRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKSLLNIHD 635
+ L L+ + D E + L++ +Q+ L D +D+ K + H+
Sbjct: 1231 KECLQHELQTIRGDLETSNLQD----MQSQEISGLKDCEIDAEE--------KYISGPHE 1278
Query: 636 -KQLQHDPAPAHTSIMSYLNKL 656
Q+D A S+ + +NKL
Sbjct: 1279 LSTSQNDNAHLQCSLQTTMNKL 1300
Score = 40.8 bits (94), Expect = 0.006
Identities = 89/443 (20%), Positives = 186/443 (41%), Gaps = 59/443 (13%)
Query: 373 TVKDVQKAKNVNKTAEKVRIIKY--------LLGELKALVAEQEDS-----EIQRLITEM 419
T K+ + + +++ A+K ++ L GEL+ L+ E + S E+ +E+
Sbjct: 2615 TAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSEL 2674
Query: 420 EACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRIL--NQQLREQQKT--QKPSG 475
+ + + + +V +A LR A+ + Q +L N+Q + +T +K +
Sbjct: 2675 KKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTS 2734
Query: 476 AVDC----NLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSI 531
+C LE+ L+S L N L+ + + E L+ + LK + K EN++
Sbjct: 2735 KEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQG- 2793
Query: 532 FKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAE-KENQILGITLRQRDA 590
K + ++++ +Q + E K L++ L ++++Q K +T + ++ +T ++
Sbjct: 2794 ---KMKLLIKSCKQLEEE----KEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKEL 2846
Query: 591 EVTRLRELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKSLLNIHDKQLQHDP-------- 642
+ T L E T+ + K S L K L + ++ +Q + D
Sbjct: 2847 KET-LEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGP 2905
Query: 643 -APAHTSIMSYLNKLETNYSFTHSEPLSTIKNEETIEPDKTYENVLSSRGPQNSNTRGME 701
P + I S K LS+ +N+ + + ++ + RGP +
Sbjct: 2906 VVPGPSPIPSVTEKR-----------LSSGQNKASGKRQRSSGIWENGRGPTPATPESFS 2954
Query: 702 EASAPGIISALSKQDSDEGSETMALIEDEHNLDNTIYIPFARSTPE--KKSPLSKRLSPQ 759
+ S ++S + + EG+E E IP +++P +++ ++ R SP+
Sbjct: 2955 KKSKKAVMSGIHPAEDTEGTEFEPEGLPEVVKKGFADIPTGKTSPYILRRTTMATRTSPR 3014
Query: 760 PQIRAATTQLVSNSGLAVSGKEN 782
Q ++ S L++ GKEN
Sbjct: 3015 -----LAAQKLALSPLSL-GKEN 3031
Score = 38.1 bits (87), Expect = 0.038
Identities = 34/129 (26%), Positives = 61/129 (47%), Gaps = 10/129 (7%)
Query: 464 LREQQKTQK--PSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQ 521
L+E+ T+K PS EL SL + +LEE ++SQ ++ KN+E+ ++ +
Sbjct: 1531 LQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIM--KNKEIQELEQLL 1588
Query: 522 KDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVK--SSQFKLETAEKENQ 579
E ++ + K L +Q+ ++T + +E+E L K + Q LE Q
Sbjct: 1589 SSERQELDCLRKQ----YLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQ 1644
Query: 580 ILGITLRQR 588
+ G+ L R
Sbjct: 1645 LQGLDLSSR 1653
Score = 32.7 bits (73), Expect = 1.6
Identities = 59/315 (18%), Positives = 142/315 (45%), Gaps = 68/315 (21%)
Query: 363 DLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITEMEAC 422
+L + V++T + + ++ ++ R ++ LL E+K L ++ E+Q L+T++EAC
Sbjct: 1771 NLQLRVKETSN----ENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQ-LMTKIEAC 1825
Query: 423 ISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRI---LNQQLR--EQQKTQKPSGA- 476
I + V +++ ++ ++ +L +++ LN L + +++ G
Sbjct: 1826 IELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDN 1885
Query: 477 ------------VDCNLELFSLQSLNMSLQNQ---LE---ESLKSQELLQSKN------- 511
+D EL ++S S++++ LE E +++++L K+
Sbjct: 1886 VAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKV 1945
Query: 512 ----EELLKVIENQKDE--------NKKFSSI------FKDKDQTILENKQQ--YDIEIT 551
EE L V+ +++++ +KK +++ K+K Q + ++ + + I++
Sbjct: 1946 IVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVA 2005
Query: 552 RIKIELEEALVNVKSS------------QFKLETAEKENQILGITLRQRDAEVTRLRELT 599
+++ + L+ SS Q KL++ EK++Q L +T + + ++ +L +
Sbjct: 2006 EAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEK 2065
Query: 600 RTLQTSMAKLLSDLS 614
L L + LS
Sbjct: 2066 ELLVKESESLQARLS 2080
Score = 30.4 bits (67), Expect = 7.8
Identities = 43/198 (21%), Positives = 85/198 (42%), Gaps = 37/198 (18%)
Query: 356 EATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQ-R 414
E +K++N +++ + + V K K+ + E I + V E+E Q
Sbjct: 1138 EQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPI--------RNSVKERESERNQCN 1189
Query: 415 LITEMEACISVLPTVSGNTD-IQVEIALAMQPLRSENAQ-----LRRQLRILNQQLR--- 465
+M+ + + S N +Q+E L + L+ + ++ L+ +L+ + L
Sbjct: 1190 FKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSN 1249
Query: 466 -EQQKTQKPSGAVDCNL-----------ELFSLQSLNMSLQ-------NQLEESLKSQEL 506
+ ++Q+ SG DC + EL + Q+ N LQ N+L E K E+
Sbjct: 1250 LQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEI 1309
Query: 507 LQSKNEELLKVIENQKDE 524
LQ++ EL+ + + + E
Sbjct: 1310 LQAEKYELVTELNDSRSE 1327
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 53.1 bits (126), Expect = 1e-06
Identities = 59/296 (19%), Positives = 121/296 (40%), Gaps = 37/296 (12%)
Query: 322 KETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTK-TVKDVQKA 380
K ++S+ R+ + L + K +E + T + V + +++++K
Sbjct: 1391 KNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ 1450
Query: 381 KNVNKTAEKVRIIKYLLGELKALVAEQEDSEI---QRLITEMEACISVLPTVSGNTDIQV 437
+ + K A EL +L ++ + E+ Q I E+E C SVL
Sbjct: 1451 REMQKAAL----------ELLSLDLKKRNQEVDLQQEQIQELEKCRSVLE---------- 1490
Query: 438 EIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQL 497
+ +A+Q + R Q+R +L + ++TQ+ + Q L + ++Q+
Sbjct: 1491 HLPMAVQEREQKLTVQREQIR----ELEKDRETQR---------NVLEHQLLELEKKDQM 1537
Query: 498 EESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIEL 557
ES + Q K L+ + + +EN + + + ++ + +T + ++L
Sbjct: 1538 IESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDL 1597
Query: 558 EEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDL 613
EE +++ ++ E + +L L++RD EV RE LQ L DL
Sbjct: 1598 EERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDL 1653
Score = 43.9 bits (102), Expect = 7e-04
Identities = 76/367 (20%), Positives = 161/367 (43%), Gaps = 64/367 (17%)
Query: 298 QGIHKETDLLKCIQTYLSL-FRSHGKETHLDSQTH------RSPTQSQPAFLATNEEKCA 350
Q + K+ ++ K LSL + +E L + RS + P + E+K
Sbjct: 1445 QELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLT 1504
Query: 351 --REQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQE 408
REQIRE +R+ +V + + ++ +K + + +V+ +K L L+ L E E
Sbjct: 1505 VQREQIRELEKDRETQR-NVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELE 1563
Query: 409 DSEI-----QRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQ----------L 453
++ Q+LI E+E T + +++ Q L+++++Q L
Sbjct: 1564 ENHHKMECQQKLIKELEGQRETQRVAL--THLTLDLEERSQELQAQSSQIHDLESHSTVL 1621
Query: 454 RRQLRILNQQLREQ----QKTQKPSGAVDCNLELFS------------------------ 485
R+L+ +Q+++ Q ++ Q+ + +LE
Sbjct: 1622 ARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKIL 1681
Query: 486 ---LQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILEN 542
L+ + +SL+ + E ++L+Q + EE + Q+ + I +DK++ + E
Sbjct: 1682 EEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEV-EC 1740
Query: 543 KQQYDIEITRIKIELEEAL--VNVKSSQFKLETAEKENQILGITLRQRDAEVTRLREL-T 599
+Q++ E+ +K +LE+ L ++ K + L +++E +I + L+Q+ E EL
Sbjct: 1741 QQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI--VVLQQQLQEAREQGELKE 1798
Query: 600 RTLQTSM 606
++LQ+ +
Sbjct: 1799 QSLQSQL 1805
Score = 42.0 bits (97), Expect = 0.003
Identities = 58/233 (24%), Positives = 101/233 (43%), Gaps = 46/233 (19%)
Query: 442 AMQPLRSENAQLRRQLRILNQQLRE--------QQKTQKPSGAVDCNLELFSLQSLNMSL 493
A+Q LR + A + + +L QQ + +Q+ QK +G D +L + L
Sbjct: 401 AVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERD------TLAGQTVDL 454
Query: 494 QNQLEESLKSQELLQSKNEEL---LKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEI 550
Q +++ K +ELLQ EEL L+V+E + ++ + + + + K++ E+
Sbjct: 455 QGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL 514
Query: 551 ---TRIKIELEEALVNVKSSQ-------FKLETAEKENQILGITLRQRDAEVT------- 593
R + L+E L+ +++ Q L A + + + G LRQ EVT
Sbjct: 515 HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAE 574
Query: 594 ----RLRELTRTLQTSMAKL------LSDLSVDSARCKPGNNLTKSLLNIHDK 636
L TL+T +A L LS L+ A K G L + LL + ++
Sbjct: 575 QSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVG--LNQQLLQLEEE 625
Score = 40.4 bits (93), Expect = 0.008
Identities = 109/583 (18%), Positives = 225/583 (38%), Gaps = 89/583 (15%)
Query: 322 KETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAK 381
K THL++Q ++ + + +E+I++ SE + H ++ T + Q +
Sbjct: 660 KNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESR----HQQEAATTQLEQLHQ 715
Query: 382 NVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITE-------------------MEAC 422
+ E ++ + E +ALV E+ E++ E +E+
Sbjct: 716 EAKRQEE---VLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESS 772
Query: 423 I-------SVLPTVSGNTDIQVE-IALAMQPLRSENAQLRRQL---RILNQQLREQQKTQ 471
+ SV+ G ++Q++ + A + ++ E L+ +L R +Q R+ Q
Sbjct: 773 LFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQ 832
Query: 472 KPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSI 531
+ L ++ + NQL E + + +EL K +E+ + E +
Sbjct: 833 LAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQ--QELAKALESLEREKMELEMR 890
Query: 532 FKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAE 591
K+ QQ ++E + + E E Q +LET EKE L TL Q E
Sbjct: 891 LKE---------QQTEMEAIQAQREEERTQAESALCQMQLET-EKERVSLLETLLQTQKE 940
Query: 592 VTRLRELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSIMS 651
+ + + +L D+ V + + + ++ L ++L+ + A H ++
Sbjct: 941 LADASQ-------QLERLRQDMKVQKLKEQETTGILQTQLQEAQRELK-EAARQHRDDLA 992
Query: 652 YLNKLETNYSFTHSEPLSTIKNEETIEPDKTYENVLSSRGPQNSNTRGMEEASAPGI--- 708
L + E S ++++ ++ K E++ S Q+ + R +E+ +
Sbjct: 993 ALQE----------ESSSLLQDKMDLQ--KQVEDLKSQLVAQDDSQRLVEQEVQEKLRET 1040
Query: 709 --ISALSKQ-DSDEGSETMALIEDEHNLDNTIYIPFARSTPEKKSPLSKRLSPQPQIRAA 765
+ + K+ + ++ S T++L+E E L + + ++ LS + +
Sbjct: 1041 QEYNRIQKELEREKASLTLSLMEKEQRL-----LVLQEADSIRQQELSALRQDMQEAQGE 1095
Query: 766 TTQLVSNSGL---AVSGKENKLCTPVICSSSTKEAEDAPEKLSRAS----DMKDTQLLKK 818
+L + L V KE EA E+ RAS + K QL +
Sbjct: 1096 QKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLR 1155
Query: 819 IKEAIGKIP--AATKEPEEQTACHGPSGCLSNSLQVKGNTVCD 859
++ ++ AA ++P Q L ++LQ +VC+
Sbjct: 1156 LRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCE 1198
Score = 38.5 bits (88), Expect = 0.029
Identities = 68/305 (22%), Positives = 129/305 (42%), Gaps = 52/305 (17%)
Query: 351 REQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQED- 409
RE+ RE T++R+ + + K Q+ + E +++I L + K + +QE
Sbjct: 1693 RERGRELTTQRQLMQERAEEGKGPSKAQRG-----SLEHMKLI--LRDKEKEVECQQEHI 1745
Query: 410 SEIQRLITEMEACISVLPTVSGNTDI-----QVEIALAMQPLRSENAQLRRQLRILNQQL 464
E+Q L ++E + L G T + + EI + Q L+ Q + + L QL
Sbjct: 1746 HELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQL 1805
Query: 465 REQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDE 524
E Q+ + EL +LQ Q Q E + + LQ E+ ++ + E
Sbjct: 1806 DEAQRA-----LAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGE 1860
Query: 525 NKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGIT 584
+D + +++ +E R++ LEE L ++++ E+ E+E +L
Sbjct: 1861 -------LQDHKEQARRLEEELAVEGRRVQA-LEEVLGDLRA-----ESREQEKALLA-- 1905
Query: 585 LRQRDAEVTRLREL-TRTLQTSMAKLLSDLSVDSARCKPGNNLTKSLLNIHDKQLQHDPA 643
L+Q+ AE + E+ TR LQ S + +++L D++L+ A
Sbjct: 1906 LQQQCAEQAQEHEVETRALQDSWLQ------------------AQAVLKERDQELEALRA 1947
Query: 644 PAHTS 648
+ +S
Sbjct: 1948 ESQSS 1952
Score = 35.8 bits (81), Expect = 0.19
Identities = 43/185 (23%), Positives = 83/185 (44%), Gaps = 21/185 (11%)
Query: 448 SENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLE--LFSLQSLNMSLQNQLE------- 498
+E +Q+ +L+ L +QL + Q+ + +LE L L SLQ++L
Sbjct: 1278 AEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRM 1337
Query: 499 ESLKSQELLQSKNEELLKVIENQKD---ENKKFSSIFKDKDQTILENKQQYDIEITRIKI 555
E+ +ELLQ+ E L +E+ + E + +S ++ + + ++ ++
Sbjct: 1338 EAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVES 1397
Query: 556 ELEEALVNVKSSQFKL---ETAEKENQILGITLRQRDAEVTRLR------ELTRTLQTSM 606
E E A + + K+ + ++ +L TL +R+ EV LR E R +Q +
Sbjct: 1398 ERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAA 1457
Query: 607 AKLLS 611
+LLS
Sbjct: 1458 LELLS 1462
Score = 33.5 bits (75), Expect = 0.93
Identities = 55/253 (21%), Positives = 108/253 (42%), Gaps = 39/253 (15%)
Query: 375 KDVQKAKNVNKT-AEKVRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNT 433
+D+Q+A+ K + ++ +++ + E +A QE +L+ E+EA S T
Sbjct: 1087 QDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQE----AQLLEELEA--------SHIT 1134
Query: 434 DIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSL 493
+ Q+ +L Q ++ AQL+ +LR QL Q+P +L SL S +L
Sbjct: 1135 EQQLRASLWAQEAKA--AQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYS---AL 1189
Query: 494 QNQLEESLKSQELLQSKNEELLKVIENQKDEN-----------------KKFSSIFKDKD 536
Q L +S+ L + V + D+N + +S
Sbjct: 1190 QQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249
Query: 537 QTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLR 596
Q + + +Q D+ +++ +LEE L + ++ + ++ T E Q L L Q E ++
Sbjct: 1250 QDLWKTQQTRDVLRDQVQ-KLEERLTDTEAEKSQVHT---ELQDLQRQLSQNQEEKSKWE 1305
Query: 597 ELTRTLQTSMAKL 609
+L++ + +L
Sbjct: 1306 GKQNSLESELMEL 1318
Score = 31.2 bits (69), Expect = 4.6
Identities = 34/174 (19%), Positives = 71/174 (40%), Gaps = 9/174 (5%)
Query: 429 VSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQS 488
+ G Q+ + LA + A R Q I + + +K + + + L Q
Sbjct: 238 MDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQK 297
Query: 489 LNMSLQNQLEESLKSQELLQSKNEELLK----VIENQKDENKKFSSIFKDKDQTILENKQ 544
N + ++ ++ E+L++ + EL++ + N ++E + KD Q ++E
Sbjct: 298 QNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGD 357
Query: 545 QY-DIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRE 597
+EL+ ++ SQF + A+K ++ L +R V LR+
Sbjct: 358 NIAQGSGHENSLELDSSIF----SQFDYQDADKALTLVRSVLTRRRQAVQDLRQ 407
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 52.8 bits (125), Expect = 1e-06
Identities = 64/334 (19%), Positives = 148/334 (44%), Gaps = 51/334 (15%)
Query: 323 ETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDT--------KTV 374
++ L+S + + S F N + + E + E K+L + D KT+
Sbjct: 1464 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1523
Query: 375 KDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTD 434
+++K + AEK+ + + L E +A + E E+ +I R E + + D
Sbjct: 1524 HELEKVRK-QLEAEKMEL-QSALEEAEASL-EHEEGKILRAQLEFNQIKAEIERKLAEKD 1580
Query: 435 IQVEIALA--MQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNL----------- 481
++E A ++ + S L + R N+ LR ++K + ++ L
Sbjct: 1581 EEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQ 1640
Query: 482 -ELFSLQSLNMSLQNQLEESLKSQE--------------LLQSKNEELLKVIENQKDENK 526
++ SLQSL Q QL++++++ + LLQ++ EEL V+E Q + ++
Sbjct: 1641 KQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE-QTERSR 1699
Query: 527 KFS-----------SIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAE 575
K + + ++ +++ K++ D ++++++ E+EEA+ ++++ K + A
Sbjct: 1700 KLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAI 1759
Query: 576 KENQILGITLRQRDAEVTRLRELTRTLQTSMAKL 609
+ ++ L++ L + + ++ ++ L
Sbjct: 1760 TDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 1793
Score = 36.2 bits (82), Expect = 0.14
Identities = 43/201 (21%), Positives = 86/201 (42%), Gaps = 29/201 (14%)
Query: 484 FSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENK 543
F ++ L S + + E + +E + K E L K +K+ +K S+ ++K+ L+ +
Sbjct: 834 FKIKPLLKSAEREKEMASMKEEFTRLK-EALEKSEARRKELEEKMVSLLQEKNDLQLQVQ 892
Query: 544 QQYDI---------EITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTR 594
+ D ++ + KI+LE VK +LE E+ N L R+ + E +
Sbjct: 893 AEQDNLADAEERCDQLIKNKIQLE---AKVKEMNERLEDEEEMNAELTAKKRKLEDECSE 949
Query: 595 LRELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLN 654
L+ L+ ++AK+ + + K NLT+ + + + I++ L
Sbjct: 950 LKRDIDDLELTLAKVEKEKHATENKVK---NLTEEMAGLDE-------------IIAKLT 993
Query: 655 KLETNYSFTHSEPLSTIKNEE 675
K + H + L ++ EE
Sbjct: 994 KEKKALQEAHQQALDDLQAEE 1014
Score = 35.0 bits (79), Expect = 0.32
Identities = 59/267 (22%), Positives = 118/267 (44%), Gaps = 20/267 (7%)
Query: 351 REQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDS 410
REQ E T + +L + +K +V + + +T R + L E K +A Q
Sbjct: 1344 REQYEEETEAKAELQRVL--SKANSEVAQWRTKYETDAIQRTEE--LEEAKKKLA-QRLQ 1398
Query: 411 EIQRLITEMEACISVLPTVSGNTDIQVE-IALAMQPLRSENAQLRRQLRILNQQLRE--Q 467
E + + + A S L ++E + + ++ + A L ++ R ++ L E Q
Sbjct: 1399 EAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 1458
Query: 468 QKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKK 527
+ + S E SL + L+N EESL+ E + +N+ L + I + ++
Sbjct: 1459 KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGS 1518
Query: 528 FSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKE-NQI---LGI 583
+ ++ ++Q + E ++ LEEA +++ + K+ A+ E NQI +
Sbjct: 1519 SGKTIHELEKV----RKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER 1574
Query: 584 TLRQRDAEVTRLR----ELTRTLQTSM 606
L ++D E+ + + + +LQTS+
Sbjct: 1575 KLAEKDEEMEQAKRNHLRVVDSLQTSL 1601
Score = 32.0 bits (71), Expect = 2.7
Identities = 69/367 (18%), Positives = 137/367 (37%), Gaps = 55/367 (14%)
Query: 399 ELKALVAEQED-----SEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQL 453
EL AL A ED S++Q+ + E++A I E+ ++ R+ A++
Sbjct: 1086 ELNALNARIEDEQALGSQLQKKLKELQARIE-------------ELEEELEAERTARAKV 1132
Query: 454 RRQLRILNQQLRE-QQKTQKPSGAVDCNLELFSLQSLNMS-LQNQLEESLKSQEL----L 507
+ L+++L E ++ ++ GA +E+ + ++ LEE+ E L
Sbjct: 1133 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1192
Query: 508 QSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSS 567
+ K+ + + + Q D ++ KQ+ + E + K+EL++ N++
Sbjct: 1193 RKKHADSVAELGEQIDNLQRV--------------KQKLEKEKSEFKLELDDVTSNMEQI 1238
Query: 568 QFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKPGNNLT 627
EK + L + + ++ + L + AKL ++ S + L
Sbjct: 1239 IKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALI 1298
Query: 628 KSLLN---IHDKQLQHDPAPAHTSIMSYLNKLETNYSFTHSEPLSTIKNEETIEPDKTYE 684
L + +QL+ + + S H L + EE E +
Sbjct: 1299 SQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQ 1358
Query: 685 NVLSSRGPQNSNTRGMEEASAPGIISALSK---------QDSDEGSETM-----ALIEDE 730
VLS + + R E A L + Q+++E E + +L + +
Sbjct: 1359 RVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTK 1418
Query: 731 HNLDNTI 737
H L N I
Sbjct: 1419 HRLQNEI 1425
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 52.0 bits (123), Expect = 3e-06
Identities = 88/432 (20%), Positives = 182/432 (42%), Gaps = 78/432 (18%)
Query: 276 KTDISAIPTLQQLGLVNGI---LPQQGIHKETDLLKCIQTYLSLFRSHGKETHLDSQTHR 332
+T+++A+ T +GL+N + + +QG+ + ++C+Q D ++
Sbjct: 3046 RTELTALGTTDAVGLLNCLEQRIQEQGVEYQA-AMECLQK-------------ADRRSLL 3091
Query: 333 SPTQSQPAFLATNEEKCAREQIREATS-ERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVR 391
S Q+ A + + REQ E S E + NI + ++ ++ + ++ A +
Sbjct: 3092 SEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATE-- 3149
Query: 392 IIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENA 451
++ L K +VAE + SE+ + E+E + Q + ++ R E
Sbjct: 3150 -LQEQLSSEKMVVAELK-SELAQTKLELETTLKA----------QHKHLKELEAFRLEVK 3197
Query: 452 QLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKN 511
++ +LN L +QK + L +L+ + + +S+E + +
Sbjct: 3198 DKTDEVHLLNDTLASEQKKSR---------------ELQWALEKEKAKLGRSEERDKEEL 3242
Query: 512 EELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKL 571
E+L +E+QK N + + + + + Q + E++Q+ + + +L E Q L
Sbjct: 3243 EDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLL 3302
Query: 572 ETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKSLL 631
E+ + + +R+ + + R REL LQ+ SD + S P +L K L
Sbjct: 3303 ESEK-------VRIREMSSTLDRERELHAQLQS------SDGTGQSRPPLPSEDLLKEL- 3348
Query: 632 NIHDKQLQHDPAPAHTSIMSYLNKLETNYSFTHSEPLSTIKNEETIEPDK-TYENVLSSR 690
KQL+ H+ I+ LN+ T L +++ + +E D+ + L +
Sbjct: 3349 ---QKQLEE----KHSRIVELLNE-------TEKYKLDSLQTRQQMEKDRQVHRKTLQTE 3394
Query: 691 GPQNSNTRGMEE 702
Q +NT G ++
Sbjct: 3395 --QEANTEGQKK 3404
Score = 48.9 bits (115), Expect = 2e-05
Identities = 66/318 (20%), Positives = 139/318 (43%), Gaps = 46/318 (14%)
Query: 351 REQIREATSERKDLNIHVRDTKTVKDVQKAKNVNK---TAEKVRIIKYLLGELKALVAEQ 407
+EQI + E K++ + + ++K K+ Q ++ + + T E+++ + + + + ++
Sbjct: 363 QEQIVQKNQEIKNMKLELTNSKQ-KERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR 421
Query: 408 EDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRR------------ 455
+ E QR + ++ A L + G +Q++ L Q + R
Sbjct: 422 MEQETQRKLEQLRA---ELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY 478
Query: 456 --------QLRILNQQLRE------QQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESL 501
Q++++N + E +QK + L L +L L++ +EE
Sbjct: 479 SNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELS 538
Query: 502 KSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEAL 561
S+E +Q + + + + +K S++ K + + ++ + ++E +K E E
Sbjct: 539 FSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELE---LKHEAE--- 592
Query: 562 VNVKSSQFKLETAEKE-NQILGITLRQRDAEVTRLR-ELTRTLQTSMAKLLSDLSVDSAR 619
V + + KLE EKE N +L ++AE+ RLR +L + + ++KL DL ++
Sbjct: 593 --VTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEH-- 648
Query: 620 CKPGNNLTKSLLNIHDKQ 637
+ K L IH KQ
Sbjct: 649 -RINIEKLKDNLGIHYKQ 665
Score = 43.9 bits (102), Expect = 7e-04
Identities = 85/413 (20%), Positives = 160/413 (38%), Gaps = 62/413 (15%)
Query: 327 DSQTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKT 386
D Q ++S+ L NE + E +R+ E+ L V++ + ++ + + K
Sbjct: 704 DLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKE 763
Query: 387 AEKVRIIKYLLGELKALVAEQEDSE----IQRLITEMEACISVLPTVSGNTDIQVEIALA 442
+ L E L E++ E I +++ E I + S + D E +
Sbjct: 764 NDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIE 823
Query: 443 MQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLK 502
+ L EN L++Q LN+++ +Q+ T FS N + Q
Sbjct: 824 I--LIEENEDLKQQCIQLNEEIEKQRNT-------------FSFAEKNFEVNYQE----- 863
Query: 503 SQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALV 562
LQ + LLKV ++ +D K +K K + + E I T +K++ + V
Sbjct: 864 ----LQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMK---SSV 916
Query: 563 NVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKP 622
+ F ET E +G + + E+ E+T+ + +++ LSDLS + + K
Sbjct: 917 FDEDKTFVAETLE-----MGEVVEKDTTELMEKLEVTKREKLELSQRLSDLS-EQLKQKH 970
Query: 623 GNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLETNYSFTHSEPLSTIKNEETIEPDKT 682
G +S+LN+ + + + E I
Sbjct: 971 GE-------------------------ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005
Query: 683 YENVLSSRGPQNSNTRGMEEASAPGIISALSKQDSDEGSETMALIEDEHNLDN 735
ENV S +S G+ ++ G ++SK + G E+ ++ED+ + +N
Sbjct: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFEN 1058
Score = 40.8 bits (94), Expect = 0.006
Identities = 66/314 (21%), Positives = 127/314 (40%), Gaps = 46/314 (14%)
Query: 330 THRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEK 389
T P + ++ + A E++ EA SE H + T+T + + + E
Sbjct: 1833 TEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATES 1892
Query: 390 VRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVLP-----------TVSGNTDI--- 435
++ + L L +E ++L E+ V+ + TDI
Sbjct: 1893 LKCQEELRERL-----HEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDR 1947
Query: 436 -QVEIALA---MQPLRSENAQLRRQLRILNQQ---------------LREQQKTQKPSGA 476
+ E+ A +Q L +E Q++ + +L++Q L+E +K K
Sbjct: 1948 LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLE 2007
Query: 477 VDCNLELF--SLQSLNMSLQNQLEESL-KSQELLQSKNEELLKVIENQKDENKKFSSIFK 533
V C E LQ +L+ +EE + + EL Q KN EL+ + + + K+ + K
Sbjct: 2008 VQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRK 2067
Query: 534 DKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVT 593
D+ ++ + + D+ I+ +LE+ L V Q E +E + L L+++ + +
Sbjct: 2068 FLDEQAIDREHERDVFQQEIQ-KLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCS 2126
Query: 594 RL----RELTRTLQ 603
L +L R +Q
Sbjct: 2127 ELLLSKEQLQRDIQ 2140
Score = 40.4 bits (93), Expect = 0.008
Identities = 91/443 (20%), Positives = 176/443 (39%), Gaps = 118/443 (26%)
Query: 346 EEKCAREQIREATSER-KDLNIHV-------------RDTKTVKDVQKAKNVNKTAEKVR 391
E +C E++R+ ++ K L I V ++T+ + Q+ + + K EK+R
Sbjct: 2007 EVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR 2066
Query: 392 IIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPT------------------VSGNT 433
K+L + +A+ E E Q+ I ++E + V+P + T
Sbjct: 2067 --KFL--DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKT 2122
Query: 434 DIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKT-------------QKPSGAVDCN 480
D E+ L+ + L+ + + ++ L ++RE ++ +K GAV+
Sbjct: 2123 DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK 2182
Query: 481 LELFSLQSLNMSLQNQ-------------LEESLKS-QELLQSKNEELLKV--------- 517
EL SL + LQ + LEE L+ +E L++KNEE+ ++
Sbjct: 2183 PEL----SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK 2238
Query: 518 -----IENQKDENKKF-------------SSIFKDKDQTILENKQQYDIEITRIKIELEE 559
++ + ENK F S +DQ +L K I+ ++I+
Sbjct: 2239 ESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN 2298
Query: 560 ALVNVKSSQFKLET----AEKENQIL--------------GITLRQRDAEVTRLRELTRT 601
V Q K+ T E++N+++ R R+ E+ +L E+
Sbjct: 2299 EQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEK 2358
Query: 602 LQTSMAKLLSDLSVDSARCKPGNNLTKSLLN--IHDKQLQHDPAPAHTSIMSYLNKL--E 657
LQ +A + S+++ + K L+ I +K M+++ + E
Sbjct: 2359 LQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKE 2418
Query: 658 TNYSFTH-SEPLSTIKNE-ETIE 678
TN+ ++ L ++K E E++E
Sbjct: 2419 TNFKMNQLTQELFSLKRERESVE 2441
Score = 38.1 bits (87), Expect = 0.038
Identities = 96/455 (21%), Positives = 194/455 (42%), Gaps = 64/455 (14%)
Query: 333 SPTQSQPAFLATNEEKCAREQIREATSERKDLNIH-VRDTKTVKDVQKAKNVNKTAEKVR 391
S Q Q A E++ + ++ S +DL V +++ K+++ T K++
Sbjct: 540 SREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIK 599
Query: 392 IIKYLLGELKALV---AEQEDSEIQRLITEM----EACISVLPTVSGNTDIQVEIALAMQ 444
+ + L E A++ AE +++E++RL T++ E +S L D+++E + ++
Sbjct: 600 L-EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL-----KEDLEIEHRINIE 653
Query: 445 PLRSE-NAQLRRQLRILNQQLREQQKT---QKPSGAVDCN---LELFSLQSLNMSLQNQL 497
L+ ++Q+ L ++ ++ +T +K + N LE+ L+ L SL N
Sbjct: 654 KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNS- 712
Query: 498 EESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIEL 557
KS+E+ N EL K IE + E K+ ++ + +++ ++K EL
Sbjct: 713 ----KSEEMTLQIN-ELQKEIEILRQEEKEKGTL-------------EQEVQELQLKTEL 754
Query: 558 EEALVNVKSS--QFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSV 615
E + K + Q K E EN IL +D + T L ++ + + T +++ + +
Sbjct: 755 LEKQMKEKENDLQEKFAQLEAENSIL------KDEKKT-LEDMLK-IHTPVSQEERLIFL 806
Query: 616 DSARCKPGNNLTKSLLNI---HDKQLQHDPAPAHTSIMSYLN-------KLETNYSFTHS 665
DS + K +++ + + I ++ L+ + I N E NY
Sbjct: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 866
Query: 666 EPLSTIKNEETIEPDKTYENVLSSRGPQNSNTRGMEEASAPGII---SALSKQDSDEGSE 722
E +K ++ +E K + + + N + P + S++ +D +E
Sbjct: 867 EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 926
Query: 723 TMALIEDEHNLDNTIYIPFARSTPEKKSPLSKRLS 757
T+ + E D T + T +K LS+RLS
Sbjct: 927 TLEMGEVVEK-DTTELMEKLEVTKREKLELSQRLS 960
Score = 30.8 bits (68), Expect = 6.0
Identities = 66/343 (19%), Positives = 132/343 (38%), Gaps = 64/343 (18%)
Query: 296 PQQGIHKETDLLKCI--QTYLSLFRSHGKETHLDSQTHRSPTQSQPAFLATNEEKCARE- 352
P+ + D LK + QTY F +GK + ++ +T +S + +C ++
Sbjct: 2463 PELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQI 2522
Query: 353 -------QIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTA-EKVRIIKYLLGELKALV 404
Q ++K +N+ K V++ A V++ E V+ + + +
Sbjct: 2523 KDMQEQGQFETEMLQKKIVNLQ----KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTIS 2578
Query: 405 AEQEDSEIQRL------------------ITEMEACISVLPTVSGNTDIQVEIALAMQPL 446
+E E + IQ L I+E+E+ + + T QVEIA L
Sbjct: 2579 SEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIA-EKNVL 2637
Query: 447 RSENAQLRRQLRILNQQLREQQKTQKPSG----AVDCNLELF------------------ 484
E L Q + + ++++K +K S + ELF
Sbjct: 2638 EKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE 2697
Query: 485 ------SLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQT 538
L S + EE L + + S ++L +V ++ + +K S + K+ +
Sbjct: 2698 SVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE 2757
Query: 539 ILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQIL 581
+ E+K+ E + I+L +++ + K+ ++ + QIL
Sbjct: 2758 VQESKKACMFE--PLPIKLSKSIASQTDGTLKISSSNQTPQIL 2798
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 52.0 bits (123), Expect = 3e-06
Identities = 88/432 (20%), Positives = 182/432 (42%), Gaps = 78/432 (18%)
Query: 276 KTDISAIPTLQQLGLVNGI---LPQQGIHKETDLLKCIQTYLSLFRSHGKETHLDSQTHR 332
+T+++A+ T +GL+N + + +QG+ + ++C+Q D ++
Sbjct: 3038 RTELTALGTTDAVGLLNCLEQRIQEQGVEYQA-AMECLQK-------------ADRRSLL 3083
Query: 333 SPTQSQPAFLATNEEKCAREQIREATS-ERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVR 391
S Q+ A + + REQ E S E + NI + ++ ++ + ++ A +
Sbjct: 3084 SEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATE-- 3141
Query: 392 IIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENA 451
++ L K +VAE + SE+ + E+E + Q + ++ R E
Sbjct: 3142 -LQEQLSSEKMVVAELK-SELAQTKLELETTLKA----------QHKHLKELEAFRLEVK 3189
Query: 452 QLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKN 511
++ +LN L +QK + L +L+ + + +S+E + +
Sbjct: 3190 DKTDEVHLLNDTLASEQKKSR---------------ELQWALEKEKAKLGRSEERDKEEL 3234
Query: 512 EELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKL 571
E+L +E+QK N + + + + + Q + E++Q+ + + +L E Q L
Sbjct: 3235 EDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLL 3294
Query: 572 ETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKSLL 631
E+ + + +R+ + + R REL LQ+ SD + S P +L K L
Sbjct: 3295 ESEK-------VRIREMSSTLDRERELHAQLQS------SDGTGQSRPPLPSEDLLKEL- 3340
Query: 632 NIHDKQLQHDPAPAHTSIMSYLNKLETNYSFTHSEPLSTIKNEETIEPDK-TYENVLSSR 690
KQL+ H+ I+ LN+ T L +++ + +E D+ + L +
Sbjct: 3341 ---QKQLEE----KHSRIVELLNE-------TEKYKLDSLQTRQQMEKDRQVHRKTLQTE 3386
Query: 691 GPQNSNTRGMEE 702
Q +NT G ++
Sbjct: 3387 --QEANTEGQKK 3396
Score = 48.9 bits (115), Expect = 2e-05
Identities = 66/318 (20%), Positives = 139/318 (43%), Gaps = 46/318 (14%)
Query: 351 REQIREATSERKDLNIHVRDTKTVKDVQKAKNVNK---TAEKVRIIKYLLGELKALVAEQ 407
+EQI + E K++ + + ++K K+ Q ++ + + T E+++ + + + + ++
Sbjct: 363 QEQIVQKNQEIKNMKLELTNSKQ-KERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR 421
Query: 408 EDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRR------------ 455
+ E QR + ++ A L + G +Q++ L Q + R
Sbjct: 422 MEQETQRKLEQLRA---ELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY 478
Query: 456 --------QLRILNQQLRE------QQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESL 501
Q++++N + E +QK + L L +L L++ +EE
Sbjct: 479 SNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELS 538
Query: 502 KSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEAL 561
S+E +Q + + + + +K S++ K + + ++ + ++E +K E E
Sbjct: 539 FSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELE---LKHEAE--- 592
Query: 562 VNVKSSQFKLETAEKE-NQILGITLRQRDAEVTRLR-ELTRTLQTSMAKLLSDLSVDSAR 619
V + + KLE EKE N +L ++AE+ RLR +L + + ++KL DL ++
Sbjct: 593 --VTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEH-- 648
Query: 620 CKPGNNLTKSLLNIHDKQ 637
+ K L IH KQ
Sbjct: 649 -RINIEKLKDNLGIHYKQ 665
Score = 43.9 bits (102), Expect = 7e-04
Identities = 85/413 (20%), Positives = 160/413 (38%), Gaps = 62/413 (15%)
Query: 327 DSQTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKT 386
D Q ++S+ L NE + E +R+ E+ L V++ + ++ + + K
Sbjct: 704 DLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKE 763
Query: 387 AEKVRIIKYLLGELKALVAEQEDSE----IQRLITEMEACISVLPTVSGNTDIQVEIALA 442
+ L E L E++ E I +++ E I + S + D E +
Sbjct: 764 NDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIE 823
Query: 443 MQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLK 502
+ L EN L++Q LN+++ +Q+ T FS N + Q
Sbjct: 824 I--LIEENEDLKQQCIQLNEEIEKQRNT-------------FSFAEKNFEVNYQE----- 863
Query: 503 SQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALV 562
LQ + LLKV ++ +D K +K K + + E I T +K++ + V
Sbjct: 864 ----LQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMK---SSV 916
Query: 563 NVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKP 622
+ F ET E +G + + E+ E+T+ + +++ LSDLS + + K
Sbjct: 917 FDEDKTFVAETLE-----MGEVVEKDTTELMEKLEVTKREKLELSQRLSDLS-EQLKQKH 970
Query: 623 GNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLETNYSFTHSEPLSTIKNEETIEPDKT 682
G +S+LN+ + + + E I
Sbjct: 971 GE-------------------------ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005
Query: 683 YENVLSSRGPQNSNTRGMEEASAPGIISALSKQDSDEGSETMALIEDEHNLDN 735
ENV S +S G+ ++ G ++SK + G E+ ++ED+ + +N
Sbjct: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFEN 1058
Score = 43.5 bits (101), Expect = 9e-04
Identities = 91/435 (20%), Positives = 176/435 (40%), Gaps = 110/435 (25%)
Query: 346 EEKCAREQIREATSER-KDLNIHV-------------RDTKTVKDVQKAKNVNKTAEKVR 391
E +C E++R+ ++ K L I V ++T+ + Q+ + + K EK+R
Sbjct: 2007 EVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR 2066
Query: 392 IIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPT------------------VSGNT 433
K+L + +A+ E E Q+ I ++E + V+P + T
Sbjct: 2067 --KFL--DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKT 2122
Query: 434 DIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKT-----QKPSGAVDCNLELFSLQS 488
D E+ L+ + L+ + + ++ L ++RE ++ +K GAV+ EL S
Sbjct: 2123 DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPEL----S 2178
Query: 489 LNMSLQNQ-------------LEESLKS-QELLQSKNEELLKV--------------IEN 520
L + LQ + LEE L+ +E L++KNEE+ ++ ++
Sbjct: 2179 LEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQE 2238
Query: 521 QKDENKKF-------------SSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSS 567
+ ENK F S +DQ +L K I+ ++I+ V
Sbjct: 2239 LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQ 2298
Query: 568 QFKLET----AEKENQIL--------------GITLRQRDAEVTRLRELTRTLQTSMAKL 609
Q K+ T E++N+++ R R+ E+ +L E+ LQ +A +
Sbjct: 2299 QLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2358
Query: 610 LSDLSVDSARCKPGNNLTKSLLN--IHDKQLQHDPAPAHTSIMSYLNKL--ETNYSFTH- 664
S+++ + K L+ I +K M+++ + ETN+
Sbjct: 2359 GQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQL 2418
Query: 665 SEPLSTIKNE-ETIE 678
++ L ++K E E++E
Sbjct: 2419 TQELFSLKRERESVE 2433
Score = 40.8 bits (94), Expect = 0.006
Identities = 66/314 (21%), Positives = 127/314 (40%), Gaps = 46/314 (14%)
Query: 330 THRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEK 389
T P + ++ + A E++ EA SE H + T+T + + + E
Sbjct: 1833 TEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATES 1892
Query: 390 VRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVLP-----------TVSGNTDI--- 435
++ + L L +E ++L E+ V+ + TDI
Sbjct: 1893 LKCQEELRERL-----HEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDR 1947
Query: 436 -QVEIALA---MQPLRSENAQLRRQLRILNQQ---------------LREQQKTQKPSGA 476
+ E+ A +Q L +E Q++ + +L++Q L+E +K K
Sbjct: 1948 LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLE 2007
Query: 477 VDCNLELF--SLQSLNMSLQNQLEESL-KSQELLQSKNEELLKVIENQKDENKKFSSIFK 533
V C E LQ +L+ +EE + + EL Q KN EL+ + + + K+ + K
Sbjct: 2008 VQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRK 2067
Query: 534 DKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVT 593
D+ ++ + + D+ I+ +LE+ L V Q E +E + L L+++ + +
Sbjct: 2068 FLDEQAIDREHERDVFQQEIQ-KLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCS 2126
Query: 594 RL----RELTRTLQ 603
L +L R +Q
Sbjct: 2127 ELLLSKEQLQRDIQ 2140
Score = 38.1 bits (87), Expect = 0.038
Identities = 96/455 (21%), Positives = 194/455 (42%), Gaps = 64/455 (14%)
Query: 333 SPTQSQPAFLATNEEKCAREQIREATSERKDLNIH-VRDTKTVKDVQKAKNVNKTAEKVR 391
S Q Q A E++ + ++ S +DL V +++ K+++ T K++
Sbjct: 540 SREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIK 599
Query: 392 IIKYLLGELKALV---AEQEDSEIQRLITEM----EACISVLPTVSGNTDIQVEIALAMQ 444
+ + L E A++ AE +++E++RL T++ E +S L D+++E + ++
Sbjct: 600 L-EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL-----KEDLEIEHRINIE 653
Query: 445 PLRSE-NAQLRRQLRILNQQLREQQKT---QKPSGAVDCN---LELFSLQSLNMSLQNQL 497
L+ ++Q+ L ++ ++ +T +K + N LE+ L+ L SL N
Sbjct: 654 KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNS- 712
Query: 498 EESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIEL 557
KS+E+ N EL K IE + E K+ ++ + +++ ++K EL
Sbjct: 713 ----KSEEMTLQIN-ELQKEIEILRQEEKEKGTL-------------EQEVQELQLKTEL 754
Query: 558 EEALVNVKSS--QFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSV 615
E + K + Q K E EN IL +D + T L ++ + + T +++ + +
Sbjct: 755 LEKQMKEKENDLQEKFAQLEAENSIL------KDEKKT-LEDMLK-IHTPVSQEERLIFL 806
Query: 616 DSARCKPGNNLTKSLLNI---HDKQLQHDPAPAHTSIMSYLN-------KLETNYSFTHS 665
DS + K +++ + + I ++ L+ + I N E NY
Sbjct: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 866
Query: 666 EPLSTIKNEETIEPDKTYENVLSSRGPQNSNTRGMEEASAPGII---SALSKQDSDEGSE 722
E +K ++ +E K + + + N + P + S++ +D +E
Sbjct: 867 EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 926
Query: 723 TMALIEDEHNLDNTIYIPFARSTPEKKSPLSKRLS 757
T+ + E D T + T +K LS+RLS
Sbjct: 927 TLEMGEVVEK-DTTELMEKLEVTKREKLELSQRLS 960
Score = 30.8 bits (68), Expect = 6.0
Identities = 66/343 (19%), Positives = 132/343 (38%), Gaps = 64/343 (18%)
Query: 296 PQQGIHKETDLLKCI--QTYLSLFRSHGKETHLDSQTHRSPTQSQPAFLATNEEKCARE- 352
P+ + D LK + QTY F +GK + ++ +T +S + +C ++
Sbjct: 2455 PELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQI 2514
Query: 353 -------QIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTA-EKVRIIKYLLGELKALV 404
Q ++K +N+ K V++ A V++ E V+ + + +
Sbjct: 2515 KDMQEQGQFETEMLQKKIVNLQ----KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTIS 2570
Query: 405 AEQEDSEIQRL------------------ITEMEACISVLPTVSGNTDIQVEIALAMQPL 446
+E E + IQ L I+E+E+ + + T QVEIA L
Sbjct: 2571 SEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIA-EKNVL 2629
Query: 447 RSENAQLRRQLRILNQQLREQQKTQKPSG----AVDCNLELF------------------ 484
E L Q + + ++++K +K S + ELF
Sbjct: 2630 EKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE 2689
Query: 485 ------SLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQT 538
L S + EE L + + S ++L +V ++ + +K S + K+ +
Sbjct: 2690 SVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE 2749
Query: 539 ILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQIL 581
+ E+K+ E + I+L +++ + K+ ++ + QIL
Sbjct: 2750 VQESKKACMFE--PLPIKLSKSIASQTDGTLKISSSNQTPQIL 2790
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 52.0 bits (123), Expect = 3e-06
Identities = 106/562 (18%), Positives = 230/562 (40%), Gaps = 86/562 (15%)
Query: 295 LPQQGIHKETDLLKCIQTYLSLFRSHGKETHLDSQTHRSPTQSQPAFLATNEEKCAREQI 354
L Q + KE+ +LK ++ L F+ H +++ +++ L E K +E+I
Sbjct: 1143 LEQDILEKESIILK-LERNLKEFQEHLQDSVKNTKD-----------LNVKELKL-KEEI 1189
Query: 355 REATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQED--SEI 412
+ T+ +D+ H+ K ++ + K E++ LKA + +E+ +++
Sbjct: 1190 TQLTNNLQDMK-HLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADL 1248
Query: 413 QRLITEMEACIS-VLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILN---QQLREQQ 468
+ +T+ + I V VS D + + + L + Q ++L + QQL+EQ
Sbjct: 1249 KEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQL 1308
Query: 469 KTQKPSGAV--------DCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIEN 520
QK A+ D N++ ++ + M+L+ Q + ++ ++L++K EE+ ++
Sbjct: 1309 NNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATE 1368
Query: 521 QKDENKKFSSI-FKDKDQTILENKQQYDI--EITRIKIELEEA----------------- 560
+ +K + + K+ ++ E++ D+ ++T ++ EL+E+
Sbjct: 1369 LEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMM 1428
Query: 561 -------LVNVKSSQFKLETAEKEN--------QILGITLRQRDAEVTRLRE----LTRT 601
N+++ + K ++E +IL L ++D+++ + RE L
Sbjct: 1429 LITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAA 1488
Query: 602 LQTSMAKLLS-----DLSVDSAR--CKPGNNLTKSLLNIHDKQLQH-DP-----APAHTS 648
L+ + L+S D ++ + + + +++I K++ DP P TS
Sbjct: 1489 LEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTS 1548
Query: 649 IMSYLNKLETNYSFTHSEPLSTIKNEETIEPDKTYENVLSSRGPQNSNTRGMEEASAPGI 708
NK+E S +ST ++ T P E + P + + +
Sbjct: 1549 FEISRNKIEDGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTV 1608
Query: 709 -ISALSKQDSDEGSETMALIEDEHNLDNTIYIPF-----ARSTPEKKSPLSKRLSPQPQI 762
I K+ S+E E + E++ N + F S+ +K+ ++ R S +
Sbjct: 1609 KIPKARKRKSNEMEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTY 1668
Query: 763 RAATTQLVSNSGLAVSGKENKL 784
+ + LA KE L
Sbjct: 1669 SLRSQASIIGVNLATKKKEGTL 1690
Score = 38.5 bits (88), Expect = 0.029
Identities = 90/446 (20%), Positives = 168/446 (37%), Gaps = 65/446 (14%)
Query: 346 EEKCAREQIREATSERKDLNIHVRDTKTVKDVQ--KAKNVNKTAEKV----RIIKYLLGE 399
E K E + + E K H K + ++ K K +N+ EK+ +I + + E
Sbjct: 549 ETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQE 608
Query: 400 LKALVAEQEDSEIQRLITEMEAC-------ISVLPTVSGNTDIQVEIALAMQPLRSENAQ 452
A++E + L+ E E +++ + G D + E A + + E +
Sbjct: 609 FTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEE 668
Query: 453 LRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNE 512
L + Q++ + K + EL ++ + SL +LE S K + +
Sbjct: 669 ATACLELKFNQIKAELAKTKGE-LIKTKEELKKRENESDSLIQELETSNKKIITQNQRIK 727
Query: 513 ELLKVIENQKDENKKFSSI-------FK-----DKDQTILENKQ--QYDIEI---TRIKI 555
EL+ +I+ ++D +F ++ FK D I+ NK +E+ ++ KI
Sbjct: 728 ELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKI 787
Query: 556 ELEEALVN----------VKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTS 605
E VN K + +A E+Q +R AE+ +R L +
Sbjct: 788 CSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGL 847
Query: 606 MAKLLSDLSVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLETNYSFTHS 665
A LL+ + + L K + +H +Q + ++ + ++++NY +
Sbjct: 848 RAFLLTIENELKNEKEEKAELNKQI--VHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIA 905
Query: 666 E-PLSTIKNEETIEPDKTYENVLSSRGPQNSNT--------------RGMEEASAPGIIS 710
E + KN+E E N + + +N R ++ S I
Sbjct: 906 ELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNID 965
Query: 711 ALSKQDSDEGSETMALIEDEHNLDNT 736
L+ +D GSE E NL NT
Sbjct: 966 LLNLRDLSNGSE-------EDNLPNT 984
>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
sapiens]
Length = 1133
Score = 51.6 bits (122), Expect = 3e-06
Identities = 92/460 (20%), Positives = 180/460 (39%), Gaps = 57/460 (12%)
Query: 323 ETHLDSQTHRSPTQSQPAFLATNEEKCAR-----------EQIREATSERKDLNIHVRDT 371
E + + H+ + F+ E++C R ++ +E E++ + T
Sbjct: 174 ELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELT 233
Query: 372 KT------VKDVQKAKNVNKTAEKVRIIKYLLG----ELKALVAEQEDSEIQRLITEMEA 421
K V D Q+ T ++ +I + K +AE E ++ T +E
Sbjct: 234 KLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEK 293
Query: 422 CISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNL 481
+ T + L + S+N QL+++L L++Q+ E ++T + + L
Sbjct: 294 ELQTQTTKFHQDQDTIMAKLTNED--SQNRQLQQKLAALSRQIDELEETNRSLRKAEEEL 351
Query: 482 E-----LFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFS-SIFKDK 535
+ + + N + ++EE K ++ K+EEL+K+ E +D NK+ + K
Sbjct: 352 QDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSK 411
Query: 536 DQTILENK--------QQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQ 587
D + K ++ + + K E N++ + + +E + L + +++
Sbjct: 412 DFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKE 471
Query: 588 RDAEVTRLRELTRTLQTSMAKL--LSDLSVDSARCKPGN-NLTKSLLNIHDKQLQHDPAP 644
+A +RL + TL+ + KL L+ + VD + T+ L QLQ +
Sbjct: 472 LEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNK 531
Query: 645 AHT-----------SIMSYLNKLETNYSFTHSEPLSTIKNEETIEPDKTYENVLSSRGPQ 693
T ++ S + E YS T +KN+ E +K N L SR
Sbjct: 532 VTTVTEKLIEETKRALKSKTDVEEKMYSVTKER--DDLKNKLKAEEEK--GNDLLSRVNM 587
Query: 694 NSNTRGMEEASAPGIISALSKQDSDEGSETMALIEDEHNL 733
N EA + +K + D G T AL ++ + +
Sbjct: 588 LKNRLQSLEAIEKDFLK--NKLNQDSGKSTTALHQENNKI 625
>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
sapiens]
Length = 1135
Score = 51.6 bits (122), Expect = 3e-06
Identities = 92/460 (20%), Positives = 180/460 (39%), Gaps = 57/460 (12%)
Query: 323 ETHLDSQTHRSPTQSQPAFLATNEEKCAR-----------EQIREATSERKDLNIHVRDT 371
E + + H+ + F+ E++C R ++ +E E++ + T
Sbjct: 174 ELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELT 233
Query: 372 KT------VKDVQKAKNVNKTAEKVRIIKYLLG----ELKALVAEQEDSEIQRLITEMEA 421
K V D Q+ T ++ +I + K +AE E ++ T +E
Sbjct: 234 KLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEK 293
Query: 422 CISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNL 481
+ T + L + S+N QL+++L L++Q+ E ++T + + L
Sbjct: 294 ELQTQTTKFHQDQDTIMAKLTNED--SQNRQLQQKLAALSRQIDELEETNRSLRKAEEEL 351
Query: 482 E-----LFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFS-SIFKDK 535
+ + + N + ++EE K ++ K+EEL+K+ E +D NK+ + K
Sbjct: 352 QDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSK 411
Query: 536 DQTILENK--------QQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQ 587
D + K ++ + + K E N++ + + +E + L + +++
Sbjct: 412 DFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKE 471
Query: 588 RDAEVTRLRELTRTLQTSMAKL--LSDLSVDSARCKPGN-NLTKSLLNIHDKQLQHDPAP 644
+A +RL + TL+ + KL L+ + VD + T+ L QLQ +
Sbjct: 472 LEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNK 531
Query: 645 AHT-----------SIMSYLNKLETNYSFTHSEPLSTIKNEETIEPDKTYENVLSSRGPQ 693
T ++ S + E YS T +KN+ E +K N L SR
Sbjct: 532 VTTVTEKLIEETKRALKSKTDVEEKMYSVTKER--DDLKNKLKAEEEK--GNDLLSRVNM 587
Query: 694 NSNTRGMEEASAPGIISALSKQDSDEGSETMALIEDEHNL 733
N EA + +K + D G T AL ++ + +
Sbjct: 588 LKNRLQSLEAIEKDFLK--NKLNQDSGKSTTALHQENNKI 625
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 51.6 bits (122), Expect = 3e-06
Identities = 87/396 (21%), Positives = 159/396 (40%), Gaps = 65/396 (16%)
Query: 352 EQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAE-KVRIIKYLLGELKALVAEQEDS 410
E+IRE +++ + K V+ Q+ + +T E ++R +K L +V E+ D+
Sbjct: 810 EKIREQLRRKEE-----QYRKEVEVKQQLELSLQTLEMELRTVK---SNLNQVVQERNDA 861
Query: 411 EIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRIL---NQQLREQ 467
+ Q L E A + ++ + Q EI +A + + SEN+ + + L N L+E+
Sbjct: 862 QRQ-LSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEE 920
Query: 468 QKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKK 527
+ LE+ ++++ N + + E LK +++ KNE+L K I
Sbjct: 921 IAMLR--------LEIDTIKNQNQEKEKKCFEDLK---IVKEKNEDLQKTI--------- 960
Query: 528 FSSIFKDKDQTILENKQQYDIEITRIKIE---LEEALVNVKSSQFKLET-AEKENQILGI 583
K ++T+ + QY+ ++ + E L L N K S+ +LE E + L
Sbjct: 961 -----KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAA 1015
Query: 584 TLRQRDAEVTRLRELTRTLQTS---MAKLLSDLSVDSARCKPGNN-LTKSLLNIHDKQLQ 639
+ RD T REL Q + ++L ++ D + K N L++ L K
Sbjct: 1016 AIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESK--- 1072
Query: 640 HDPAPAHTSIMSYLNKLETNYSFTHSEPLSTIKNEETIEPDKTYENVLSSRGPQNSNTRG 699
LN LE + T E ++ D + Q
Sbjct: 1073 -------------LNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQ 1119
Query: 700 MEEASAPGIISALSKQDSDEGSETMAL---IEDEHN 732
++ G ++ ++ S SE M L ++D HN
Sbjct: 1120 VKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHN 1155
Score = 40.0 bits (92), Expect = 0.010
Identities = 60/315 (19%), Positives = 133/315 (42%), Gaps = 35/315 (11%)
Query: 331 HRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKN-----VNK 385
H + + ++ A Q +A SE++ L + R+ + + + K N+
Sbjct: 1154 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENE 1213
Query: 386 TAEKVRIIKYLLGELKALVAEQEDSEIQRLITE-----MEACISVLPTVSGNTDIQVEIA 440
AE+ +++ L EL + +Q SE +T +E L G Q++ A
Sbjct: 1214 KAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEA 1273
Query: 441 LAM---------------QPLRSENAQLRRQLRILNQQLREQQKTQKPSG-AVDCNLELF 484
Q L +NA+L+ ++ ++ E QK + + D +L
Sbjct: 1274 QDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLK 1333
Query: 485 SLQSLNMSLQNQLEESLKSQELLQSKN---EELLKVIENQKDENKKFSSIFKDKDQTILE 541
L L SL+ L++ +K L+ + + LLK+ + +E + F +T
Sbjct: 1334 KLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKT--- 1390
Query: 542 NKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILG---ITLRQRDAEVTRLREL 598
++ + DI+I ++K ++++ ++++ K + +NQIL ++++ + +L++
Sbjct: 1391 SQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKN 1450
Query: 599 TRTLQTSMAKLLSDL 613
+ L+ + L S +
Sbjct: 1451 KKKLEQEVINLRSHI 1465
Score = 38.1 bits (87), Expect = 0.038
Identities = 43/224 (19%), Positives = 94/224 (41%), Gaps = 41/224 (18%)
Query: 436 QVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQN 495
Q + + L+SEN LR+QL + + ++KT + ++Q ++
Sbjct: 1129 QESVEERLSQLQSENMLLRQQLDDAHNKADNKEKT------------VINIQDQFHAIVQ 1176
Query: 496 QLE-ESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIK 554
+L+ ES K LL+ +N+EL+ + K+ ++ + K + ++ + +++
Sbjct: 1177 KLQAESEKQSLLLEERNKELISECNHLKERQYQYEN-----------EKAEREVVVRQLQ 1225
Query: 555 IELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEV-TRLRELTRTLQTSMAKLLSDL 613
EL + L S+ LE + I L ++ +L ++ LQ + D
Sbjct: 1226 QELADTLKKQSMSEASLEVTSRYR----INLEDETQDLKKKLGQIRNQLQEA-----QDR 1276
Query: 614 SVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLE 657
++ RC + H ++L+ D A ++ ++K+E
Sbjct: 1277 HTEAVRC-------AEKMQDHKQKLEKDNAKLKVTVKKQMDKIE 1313
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 50.8 bits (120), Expect = 6e-06
Identities = 100/485 (20%), Positives = 192/485 (39%), Gaps = 89/485 (18%)
Query: 233 VHSEVQTDGNSQFASQGKTVSA-TCTDVLRNSFNTSPGVPCSLP-----KTDI----SAI 282
+H +VQ A+Q + +S T + L + N S L KT++ A
Sbjct: 598 LHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAA 657
Query: 283 PTLQQLGLVNGILP--------QQGIHKETDLLKCI-------QTYLSLFRSHGKE---- 323
T Q+ L N + QQ ++K T L + Q + S SH KE
Sbjct: 658 KTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEK 717
Query: 324 -THLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLN--IHVRDTKTVKDVQKA 380
L+ +T Q + + E K ++EQ + +++ LN + +R T+ K ++
Sbjct: 718 YLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEME 777
Query: 381 KNV----------------------NKTAEKVRIIKY---LLGELKALVAEQEDSEIQRL 415
K + K E+ +I+K L + + E+ ++ IQ
Sbjct: 778 KEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTT 837
Query: 416 ITEM-------EACISVLPTVSGN-TDIQVEIALAMQPLRSENA--------------QL 453
+TE+ EA ++ L TV + + + + EN +L
Sbjct: 838 VTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL 897
Query: 454 RRQLRILNQQLREQQKTQKPS------GAVDCNLELFSLQSLNMSLQNQLEESLKSQELL 507
+ QL++ + ++QK K S + LEL S+Q + QN L+++ K ++ L
Sbjct: 898 KHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL 957
Query: 508 QSKNEELLKVIENQKDENKKFSSIFKDK--DQTILENKQQYDIEITRIKIELEEALVNVK 565
Q EL + E +K + + K +T LENK Q + ++ E+ ++V
Sbjct: 958 QGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVL 1017
Query: 566 SSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKPGNN 625
+ + E +++ + L R++E+ R+ ++++ ++ DL + + N
Sbjct: 1018 QNNY--EKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNK 1075
Query: 626 LTKSL 630
L + L
Sbjct: 1076 LIQEL 1080
Score = 38.1 bits (87), Expect = 0.038
Identities = 66/287 (22%), Positives = 124/287 (43%), Gaps = 34/287 (11%)
Query: 336 QSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKY 395
+SQ F + RE E + R+DL V + ++ N N+ + ++I+
Sbjct: 1023 KSQETFKQLQSDFYGRES--ELLATRQDLK-SVEEKLSLAQEDLISNRNQIGNQNKLIQ- 1078
Query: 396 LLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRR 455
ELK A E ++ E C ++ DIQ E +L + L +E ++L
Sbjct: 1079 ---ELKTAKATLEQDSAKKEQQLQERCKAL-------QDIQKEKSLKEKELVNEKSKLAE 1128
Query: 456 QLRILNQQLREQQKTQKP--SGAVDCNLELFSLQSLNMSL-QNQLE-----ESLKSQELL 507
I +Q +E K + S ++ E+ +L+ L Q +LE +SLK+
Sbjct: 1129 IEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ 1188
Query: 508 QSKNEELLK-VIENQKDENKK--------FSSIFKDKDQTIL---ENKQQYDIEITRIKI 555
+ +N+++LK ++ +++E KK S K+K+ + EN+ + ++IT +
Sbjct: 1189 EKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNE 1248
Query: 556 ELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTL 602
L +SSQ ++ EK+ L + +A V ++ R L
Sbjct: 1249 NLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL 1295
Score = 33.1 bits (74), Expect = 1.2
Identities = 91/438 (20%), Positives = 171/438 (39%), Gaps = 50/438 (11%)
Query: 297 QQGIHKETDL----LKCIQTYLSLFRSHG--KETHLDSQTHRSPTQSQPAFLATNEEKCA 350
Q G+ ++++ K ++T L +HG KE S + Q A L +
Sbjct: 407 QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL- 465
Query: 351 REQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDS 410
EQ++E + +L + TK Q+A + TA K+R + L ++ + +++
Sbjct: 466 EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTA-KLREAQNDLEQVLRQIGDKDQK 524
Query: 411 --EIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQ 468
++ L+ + + IS+L D+ +I Q E A L QL+ N L+EQ
Sbjct: 525 IQNLEALLQKSKENISLLE--KEREDLYAKI----QAGEGETAVLN-QLQEKNHTLQEQ- 576
Query: 469 KTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKF 528
+ L L+NQ E ++QE L + +E + +D
Sbjct: 577 -----------------VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSL 619
Query: 529 SSIFKDKDQTILENKQ---QYDIEI---TRIKIELEEALVNVKSS-QFKLETAEKENQIL 581
+ + + + E+K+ Q DI+I T + + E A ++ Q L+TA+ Q
Sbjct: 620 ETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679
Query: 582 GITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKSLLNIHDKQLQHD 641
L + ++ ++ + Q ++L S L + T+ L K+L+ D
Sbjct: 680 QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG-QIKKLEAD 738
Query: 642 PAPAHTSIMSYLNKLETNYSFTHSEPLSTIKNEETIEPDKTYENVLSSRGPQNSNTRGME 701
S L L+ L + + +E +K E V S+R + +E
Sbjct: 739 SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEK--EIVSSTRLDLQKKSEALE 796
Query: 702 EASAPGIISALSKQDSDE 719
I L+KQ+ ++
Sbjct: 797 -----SIKQKLTKQEEEK 809
>gi|4505541 USO1 homolog, vesicle docking protein [Homo sapiens]
Length = 962
Score = 50.4 bits (119), Expect = 7e-06
Identities = 62/317 (19%), Positives = 137/317 (43%), Gaps = 47/317 (14%)
Query: 388 EKVRIIKYLLGEL-----KALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVE-IAL 441
E +++K L G + K+ ++++ E+++ + + + ++ + D+Q+E +
Sbjct: 612 EFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQ 671
Query: 442 AMQPLRSENAQLRRQLRILNQQLREQQ-----------KTQKPSGAVDCNLELFSLQSLN 490
+ L+ +N QL+ + Q+++ + K + G+ ++ +Q
Sbjct: 672 QVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEE 731
Query: 491 MS-LQNQLEESLKSQELLQSKNEELLKVIENQKDE-----NKKFSSIFKDKD-QTILENK 543
+ L+ ++EE ++QELLQS+ E +IEN K N++ S+I +D + + E K
Sbjct: 732 IGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELK 791
Query: 544 QQ----------YDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVT 593
Q+ +EIT+++ E +E L ++ +E + I+ + ++
Sbjct: 792 QELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLS 851
Query: 594 RLRELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKSL--------LNIHDKQLQHDP--- 642
L + T+ L+ + L + + + N+ L L I D + + D
Sbjct: 852 ALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLV 911
Query: 643 --APAHTSIMSYLNKLE 657
A I+S NKL+
Sbjct: 912 LLADQDQKILSLKNKLK 928
Score = 38.5 bits (88), Expect = 0.029
Identities = 40/202 (19%), Positives = 92/202 (45%), Gaps = 18/202 (8%)
Query: 346 EEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNV--NKTAEKVRIIKYLLGELKAL 403
E K +E ++ +E+ + +++ ++T +++ + + +E+V +K L LK+
Sbjct: 741 ELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQ 800
Query: 404 VAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQ 463
+ Q EI +L TE + + + + ++Q E + ++ + +L L Q+
Sbjct: 801 LNSQS-VEITKLQTEKQELLQKTEAFAKSVEVQGETETI---IATKTTDVEGRLSALLQE 856
Query: 464 LREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKD 523
+E + E+ +L +++ QL+ S + +LQ++ ++L I + K
Sbjct: 857 TKELKN------------EIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKK 904
Query: 524 ENKKFSSIFKDKDQTILENKQQ 545
E + D+DQ IL K +
Sbjct: 905 EQDDLLVLLADQDQKILSLKNK 926
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 50.4 bits (119), Expect = 7e-06
Identities = 45/274 (16%), Positives = 121/274 (44%), Gaps = 17/274 (6%)
Query: 352 EQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRI---IKYLLGELKALVAEQE 408
+ + E RK L + + ++ + +A ++ + +R + E++ +AE++
Sbjct: 1523 KNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD 1582
Query: 409 DSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQ 468
+ Q S+ ++ T + E+ + + + ++ QL N+ E Q
Sbjct: 1583 EEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQ 1642
Query: 469 KTQKPSGAV--DCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENK 526
K K ++ D ++L N L+ + + LLQ++ EEL V+E Q + ++
Sbjct: 1643 KQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE-QTERSR 1701
Query: 527 KFS-----------SIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAE 575
K + + ++ +++ K++ + ++T+++ E+EEA+ ++++ K + A
Sbjct: 1702 KLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAI 1761
Query: 576 KENQILGITLRQRDAEVTRLRELTRTLQTSMAKL 609
+ ++ L++ L + + ++ ++ L
Sbjct: 1762 TDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 1795
Score = 36.6 bits (83), Expect = 0.11
Identities = 43/206 (20%), Positives = 91/206 (44%), Gaps = 18/206 (8%)
Query: 484 FSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENK 543
F ++ L S + + E + +E + K E L K +K+ +K S+ ++K+ L+ +
Sbjct: 836 FKIKPLLKSAETEKEMATMKEEFGRIK-ETLEKSEARRKELEEKMVSLLQEKNDLQLQVQ 894
Query: 544 QQYDI---------EITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTR 594
+ D ++ + KI+LE VK +LE E+ N L R+ + E +
Sbjct: 895 AEQDNLNDAEERCDQLIKNKIQLE---AKVKEMNERLEDEEEMNAELTAKKRKLEDECSE 951
Query: 595 LRELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKSLLNIHD--KQLQHDPAPAHTSIMSY 652
L++ L+ ++AK+ + + K NLT+ + + + +L + +
Sbjct: 952 LKKDIDDLELTLAKVEKEKHATENKVK---NLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1008
Query: 653 LNKLETNYSFTHSEPLSTIKNEETIE 678
L+ L+ +S S +K E+ ++
Sbjct: 1009 LDDLQVEEDKVNSLSKSKVKLEQQVD 1034
Score = 35.8 bits (81), Expect = 0.19
Identities = 57/267 (21%), Positives = 121/267 (45%), Gaps = 20/267 (7%)
Query: 351 REQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDS 410
REQ E T + +L + +K +V + + +T + ++ + L K L +D+
Sbjct: 1346 REQYEEETEAKAELQRVL--SKANSEVAQWRTKYET-DAIQRTEELEEAKKKLAQRLQDA 1402
Query: 411 EIQRLITEMEACISVLPTVSGNTDIQVE-IALAMQPLRSENAQLRRQLRILNQQLRE--Q 467
E + + A S L ++E + + ++ + A L ++ R ++ L E Q
Sbjct: 1403 E--EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 1460
Query: 468 QKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKK 527
+ + S E SL + L+N EESL+ E + +N+ L + I + ++ +
Sbjct: 1461 KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGE 1520
Query: 528 FSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKE-NQI---LGI 583
+ ++ ++Q ++E ++ LEEA +++ + K+ A+ E NQI +
Sbjct: 1521 GGKNVHELEKV----RKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER 1576
Query: 584 TLRQRDAEVTRLR----ELTRTLQTSM 606
L ++D E+ + + + +LQTS+
Sbjct: 1577 KLAEKDEEMEQAKRNHQRVVDSLQTSL 1603
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 50.1 bits (118), Expect = 1e-05
Identities = 52/252 (20%), Positives = 122/252 (48%), Gaps = 26/252 (10%)
Query: 387 AEKVRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPL 446
AEK+++ + L E + L AE E+ RL + + + + + + E Q L
Sbjct: 880 AEKLQLQEQLQAETE-LCAEAEELRA-RLTAKKQELEEICHDLEARVEEEEE---RCQHL 934
Query: 447 RSENAQLRRQLRILNQQLREQQKTQKPSGA--VDCNLELFSLQSLNMSLQNQLEESLKSQ 504
++E ++++ ++ L +QL E++ ++ V +L L+ + L++Q + K +
Sbjct: 935 QAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEK 994
Query: 505 ELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTIL---------ENKQQYDIEITRIKI 555
+LL+ + E + +++++K + + K+K + ++ E KQ+ ++E TR K+
Sbjct: 995 KLLEDRIAEFTTNLTEEEEKSKSLAKL-KNKHEAMITDLEERLRREEKQRQELEKTRRKL 1053
Query: 556 ELEE-------ALVNVKSSQFKLETAEKENQILGITLR--QRDAEVTRLRELTRTLQTSM 606
E + A + + ++ K++ A+KE ++ R + A+ + R L++ +
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113
Query: 607 AKLLSDLSVDSA 618
++L DL + A
Sbjct: 1114 SELQEDLESERA 1125
Score = 49.3 bits (116), Expect = 2e-05
Identities = 108/551 (19%), Positives = 216/551 (39%), Gaps = 52/551 (9%)
Query: 279 ISAIPTLQQLGLVNGILPQQGIHKETDLLKCIQTYLSLFRSHGKETHLDSQTHRSPTQSQ 338
++ + TLQ + + Q+ + ET+L C + R K+ L+ H
Sbjct: 868 LTEMETLQSQLMAEKLQLQEQLQAETEL--CAEAEELRARLTAKKQELEEICH-----DL 920
Query: 339 PAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLG 398
A + EE+C Q +E+K + ++++ + + +++ EKV
Sbjct: 921 EARVEEEEERCQHLQ-----AEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE----A 971
Query: 399 ELKALVAEQEDSEIQ--RLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSEN----AQ 452
+LK L EQ E Q +L E + + + N + E + ++ L++++
Sbjct: 972 KLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITD 1031
Query: 453 LRRQLRILNQQLREQQKTQKP--SGAVDCNLELFSLQSLNMSLQNQL---EESLKS---- 503
L +LR +Q +E +KT++ + D + ++ LQ+ L+ QL EE L++
Sbjct: 1032 LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALAR 1091
Query: 504 -QELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDI--EITRIKIELEEA 560
+E KN L K+ E + ++ + ++ KQ+ D+ E+ +K ELE+
Sbjct: 1092 VEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDT 1151
Query: 561 LVNVKSSQFKLETAEKENQILGITLRQ----RDAEVTRLRELTRTLQTSMAKLLSDLSVD 616
L + + Q E+E IL TL + +A++ +R+ +A+ L
Sbjct: 1152 LDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRV 1211
Query: 617 SARCKPG----NNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLETNYSFTHSEPLSTIK 672
A + N L N LQ H E F E + T
Sbjct: 1212 KANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTEL 1271
Query: 673 NEETIEPDKTYENVLSSRGPQNSNTRGMEEASAPGIISALSKQDSDEGSETMALIEDEHN 732
++ + +NV +S + + + SAL Q D T L+++E+
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKD-----FSALESQLQD----TQELLQEENR 1322
Query: 733 LDNTIYIPFARSTPEKKSPLSKRLSPQPQIRAATTQLVSNSGLAVSGKENKLCTPVICSS 792
++ + EK S ++L + + + + ++ V+ + K+ V C
Sbjct: 1323 QKLSLSTKLKQVEDEKNS-FREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLE 1381
Query: 793 STKEAEDAPEK 803
+ +E + +K
Sbjct: 1382 TAEEVKRKLQK 1392
Score = 42.0 bits (97), Expect = 0.003
Identities = 72/317 (22%), Positives = 129/317 (40%), Gaps = 43/317 (13%)
Query: 302 KETDLLKCIQTYLSLFRSHGKETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSER 361
K D + C++T + R K+ SQ H EEK A E T R
Sbjct: 1372 KMEDSVGCLETAEEVKRKLQKDLEGLSQRH--------------EEKVAAYDKLEKTKTR 1417
Query: 362 KDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITEMEA 421
+ Q A N+ K +K LL E K + A+ + +R E EA
Sbjct: 1418 LQQELDDLLVDLDHQRQSACNLEKKQKK---FDQLLAEEKTISAKYAE---ERDRAEAEA 1471
Query: 422 CISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNL 481
+S +A A++ + A+L R LN+Q R + + S D
Sbjct: 1472 REKETKALS--------LARALEEAMEQKAELER----LNKQFRTEMEDLM-SSKDDVGK 1518
Query: 482 ELFSLQSLNMSLQNQLEESLKSQ-----ELLQSKNEELLKVIENQKDENKKFSSIFKDKD 536
+ L+ +L+ Q+EE +K+Q + LQ+ + L++ N + +F + +D
Sbjct: 1519 SVHELEKSKRALEQQVEE-MKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRD 1577
Query: 537 QTILENKQQYDIEITRIKIELEEALVN---VKSSQFKLETAEKENQI-LGITLRQRDAEV 592
+ E K+Q ++ ++ ELE+ +++ KLE K+ + + + RD +
Sbjct: 1578 EQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAI 1637
Query: 593 TRLRELTRTLQTSMAKL 609
+LR+L ++ M +L
Sbjct: 1638 KQLRKLQAQMKDCMREL 1654
Score = 36.2 bits (82), Expect = 0.14
Identities = 38/162 (23%), Positives = 76/162 (46%), Gaps = 8/162 (4%)
Query: 452 QLRRQLRILNQQLREQQKTQKPSGAVDCNL-ELFSLQSLNMSLQNQLEESLKSQELLQSK 510
Q+ RQ + + E K ++ A + L E+ +LQS M+ + QL+E L+++ L ++
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898
Query: 511 NEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFK 570
EEL + +K E I D + + E +++ ++ E ++ N++ + +
Sbjct: 899 AEELRARLTAKKQE---LEEICHDLEARVEEEEER----CQHLQAEKKKMQQNIQELEEQ 951
Query: 571 LETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSD 612
LE E Q L + +A++ +L E L+ KL +
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKE 993
Score = 34.3 bits (77), Expect = 0.54
Identities = 55/259 (21%), Positives = 109/259 (42%), Gaps = 21/259 (8%)
Query: 351 REQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDS 410
R+Q A + RK L + ++D + D + N N+ E ++ ++ L ++K + E +D+
Sbjct: 1602 RKQRSMAVAARKKLEMDLKDLEAHID---SANKNRD-EAIKQLRKLQAQMKDCMRELDDT 1657
Query: 411 EIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKT 470
R +L N + M L+ E A R R Q+ R++
Sbjct: 1658 RASRE--------EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQE-RDELAD 1708
Query: 471 QKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSS 530
+ + + L L + L + QLEE L+ ++ + LK Q D+ +
Sbjct: 1709 EIANSSGKGALALEEKRRLEARIA-QLEEELEEEQGNTELINDRLKKANLQIDQINTDLN 1767
Query: 531 IFKDKDQTILENKQQYDIEITRIKIELEEALVNVKS------SQFKLETAEKENQILGIT 584
+ + Q +QQ + + +K++L+E VKS + + + A+ E Q+ T
Sbjct: 1768 LERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNET 1827
Query: 585 LRQRDAEVTRLRELTRTLQ 603
++R A ++R + L+
Sbjct: 1828 -KERQAACKQVRRTEKKLK 1845
>gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens]
Length = 1505
Score = 50.1 bits (118), Expect = 1e-05
Identities = 94/472 (19%), Positives = 192/472 (40%), Gaps = 55/472 (11%)
Query: 356 EATSERKDLNIHVRDTK--TVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQ 413
E+ RK L R+ K T +D++K + ++K GE+ AL +++E
Sbjct: 26 ESEQSRKRLIEQSREFKKNTPEDLRK--------QVAPLLKSFQGEIDALSKRSKEAEAA 77
Query: 414 RLITEMEACISV---LPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKT 470
+ + I V +P + +Q+++ + + +EN +LR L N++ E +
Sbjct: 78 -FLNVYKRLIDVPDPVPALDLGQQLQLKVQ-RLHDIETENQKLRETLEEYNKEFAEVKNQ 135
Query: 471 QKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKV-------IENQKD 523
+ A+ + + N + LE+ K Q K +L + +E +
Sbjct: 136 EVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEH 195
Query: 524 ENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGI 583
+ + + + + + K +YD E T E+E + +++ + + E A++E +
Sbjct: 196 KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAE---- 251
Query: 584 TLRQRDAEVTRLRELTRTLQTS-----MAKLLSDLSVDSARCKPGNNLTKSLLNIHDKQL 638
TLR++ + +L +Q + ++L+ S++ + + + ++ ++L
Sbjct: 252 TLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDV--QRL 309
Query: 639 QHDPAPAHTSIMSYLNKLETNYSFTHSEPLSTIKN-EETIEPDKTYE------NVLSSRG 691
Q + S +++LE S + ST+K EE ++ YE N+L S
Sbjct: 310 QASLTKLRENSASQISQLEQQLSAKN----STLKQLEEKLKGQADYEEVKKELNILKSME 365
Query: 692 PQNSNTRGMEEASAPGIISALSKQDSDEGSETMALIEDEHNLDNTIYIPFARSTPEKKSP 751
S G ++A+ P + L K S + SE AL +L + + PE + P
Sbjct: 366 FAPSEGAGTQDAAKPLEVLLLEKNRSLQ-SENAALRISNSDLSGSARRK-GKDQPESRRP 423
Query: 752 LSKRLSPQPQIRAATTQLVSN---------SGLAVSGKENKLCTPVICSSST 794
S P Q+ + SN +GL+ + L +P + +ST
Sbjct: 424 GSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLAST 475
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 49.7 bits (117), Expect = 1e-05
Identities = 84/382 (21%), Positives = 158/382 (41%), Gaps = 42/382 (10%)
Query: 405 AEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQL 464
+E+E+ E+ E E S + V G + ++ + Q + + LRRQ + QQL
Sbjct: 326 SEEEEEEVP----EQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQL 381
Query: 465 REQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQEL--LQSKNEELLKVIENQK 522
REQ++ ++ +L + + + Q + L+ Q+ +++ ++ + ++
Sbjct: 382 REQEEYKR---------QLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQ 432
Query: 523 DENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEK---ENQ 579
+E ++ + + + + E +++ + E R++ E E ++ Q LE ++ + Q
Sbjct: 433 EEKRRLEELERRRKEE--EERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQ 490
Query: 580 ILGITLRQRDAEVTRLRE-LTRTLQTSMAKLLSDLSVDSARCKPGNN-LTKSLLNIHDKQ 637
+ + R R+ E R E L R LQ A LLS L D R P ++ K
Sbjct: 491 AMLLECRWREMEEHRQAERLQRQLQQEQAYLLS-LQHDHRRPHPQHSQQPPPPQQERSKP 549
Query: 638 LQHDPAP-AHTSIMSYLNKLETNYSFT-HSEPLSTIKNE-ETIEPDKTYENVLSSRGPQN 694
H P P AH ++E + T HS P + K +EP + S G
Sbjct: 550 SFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSE 609
Query: 695 SNTRGMEEASAPGI-----------ISALSKQDS-DEGSETMALIEDEHNLDNTIYIPFA 742
S ++ + P + +S +S+ S + S A H+L + P +
Sbjct: 610 SVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFA----HHHLRSQDPCPPS 665
Query: 743 RSTPEKKSPLSKRLSPQPQIRA 764
RS +S SK +P P +A
Sbjct: 666 RSEVLSQSSDSKSEAPDPTQKA 687
>gi|34878777 ring finger protein 20 [Homo sapiens]
Length = 975
Score = 49.3 bits (116), Expect = 2e-05
Identities = 66/320 (20%), Positives = 132/320 (41%), Gaps = 37/320 (11%)
Query: 346 EEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVA 405
E + RE+ +E E++ L ++ + KD +K K+ + ++ IIK L ELK
Sbjct: 579 EREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQE 638
Query: 406 EQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLR 465
Q+ EM+ + + + +V++ A + ++E LR++L+ L + +
Sbjct: 639 SQK---------EMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEK 689
Query: 466 EQQKTQKPSGA---VDCNLELFSLQSLNMSLQNQLEESLKSQ--------ELLQSKNEEL 514
++ K A + E +++ Q EE+L S+ E +Q +N L
Sbjct: 690 KENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRL 749
Query: 515 LKVIENQKDENKKFSSIFKDKDQ---TILENKQQYDIEITRIKIELEEALVNVKSSQFK- 570
++ + + D N K S +Q + E K++ ++ +K +++ L V+ + K
Sbjct: 750 MQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKE 809
Query: 571 ------LETAEKENQILGITLRQRDAEVTRLRELTRTLQTSM---AKLLSDLSVDSARCK 621
+ T EKE + L + +L L+ + K L D +
Sbjct: 810 HLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVE-- 867
Query: 622 PGNNLTKSLLNIHDKQLQHD 641
N++TK + K+ Q D
Sbjct: 868 --NSVTKEKDMFNFKRAQED 885
Score = 30.4 bits (67), Expect = 7.8
Identities = 53/282 (18%), Positives = 114/282 (40%), Gaps = 29/282 (10%)
Query: 358 TSERKDLNIHVRDTKTVKDVQKAKNVNKTAE--------KVRIIKYLLGELKALVAEQED 409
TS + V D+ T + K V+ T E K R + +L + +A+ E +
Sbjct: 15 TSMPPEKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELRE 74
Query: 410 --SEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRIL------- 460
+++R +A + ++ D + I L L L + + L
Sbjct: 75 HIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEP 134
Query: 461 ----NQQL---REQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEE 513
NQ+ RE+ + Q+P+ + L S + + LQ ++E S ++ + + ++
Sbjct: 135 DSDSNQERKDDRERGEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDK 194
Query: 514 LLKVIEN-QKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSS----Q 568
L + +E + N + I ++ Q + Q ++ + + L+E + Q
Sbjct: 195 LQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQ 254
Query: 569 FKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLL 610
K+ETAE +L + ++ ++R+ + L +A++L
Sbjct: 255 SKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVL 296
>gi|7705415 hook homolog 1 [Homo sapiens]
Length = 728
Score = 49.3 bits (116), Expect = 2e-05
Identities = 71/332 (21%), Positives = 139/332 (41%), Gaps = 47/332 (14%)
Query: 300 IHKETDLLKCIQTYLSLFRSHGKETH--LDSQTHRSPT---------QSQPAFLATNEEK 348
+ +E +T L ++ ++ H L S++ R+ T + A L E
Sbjct: 357 LEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERL 416
Query: 349 CAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKY------LLGELKA 402
+ + T+E + +D D K+ A ++ ++Y L E K
Sbjct: 417 IEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKM 476
Query: 403 LVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQ 462
L +QE SE +R I E++ + + M L +E + ++R L Q
Sbjct: 477 LRLQQEGSENER-IEELQEQLE-------------QKHRKMNELETEQRLSKERIRELQQ 522
Query: 463 QLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQK 522
Q+ + QK+ + G+ E S L L+ +E+ + E LQ K +EL++ ++
Sbjct: 523 QIEDLQKSLQEQGS---KSEGESSSKLKQKLEAHMEKLTEVHEELQ-KKQELIEDLQPDI 578
Query: 523 DEN-KKFSSI-----FKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKL---ET 573
++N +K + + KD+D +E + + +E R I+ + +N S++ L +
Sbjct: 579 NQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQL 638
Query: 574 AEKENQILGITLRQRDAEVTRLRELTRTLQTS 605
AEKE + I + + + +V + R+ L S
Sbjct: 639 AEKERR---IEILESECKVAKFRDYEEKLIVS 667
Score = 31.6 bits (70), Expect = 3.5
Identities = 53/281 (18%), Positives = 116/281 (41%), Gaps = 40/281 (14%)
Query: 367 HVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVL 426
H+++ T+++ ++V TA + + K +L + + +++R + E++ ++
Sbjct: 137 HIQNIMTLEE--SVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEK 194
Query: 427 PTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAV------DCN 480
+ + E+ + + L+ E L + ++N++L + + V
Sbjct: 195 EELRQRCE---ELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQ 251
Query: 481 LELFSLQSLNMSLQNQLE------ESLKSQEL-LQSKNEELLKVIENQK----------- 522
L+L LQ N L+ + E L+ Q + Q +N+EL + E +
Sbjct: 252 LQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRA 311
Query: 523 --DENKKFSS---IFKDKDQTILE-NKQQYDIEITRIK-----IELEEALVNVKSSQFKL 571
D+ K S I++ K Q + + KQ ++ T + + LEE L +++ +L
Sbjct: 312 TSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQL 371
Query: 572 ETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSD 612
ET +++ Q L + L L + L+ LL +
Sbjct: 372 ETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKE 412
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 49.3 bits (116), Expect = 2e-05
Identities = 62/268 (23%), Positives = 119/268 (44%), Gaps = 43/268 (16%)
Query: 406 EQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQL--RILNQQ 463
+Q + E QRL+T +E + L IQ+E +EN+ L+ + R Q
Sbjct: 630 KQYEKERQRLVTGIEELRTKL--------IQIE---------AENSDLKVNMAHRTSQFQ 672
Query: 464 LREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESL--------KSQEL---LQSKNE 512
L +++ +K S + E+ S ++L+ QLEE + K+ EL L KNE
Sbjct: 673 LIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNE 732
Query: 513 ELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLE 572
++ + N E++K F+ + LE ++ + +I R++ +LE+ K QFK
Sbjct: 733 KIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEK-----KDQQFK-- 785
Query: 573 TAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSD-LSVDSARCKPGNNLTKSLL 631
++ + + + + + L L R L S ++ + + D A N +++ +
Sbjct: 786 ---EQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETI 842
Query: 632 NIHDKQLQHDPAPAHTSIMSYLNKLETN 659
+ +QL ++ +LN+LE N
Sbjct: 843 KV--RQLDSALEICKEELVLHLNQLEGN 868
Score = 48.9 bits (115), Expect = 2e-05
Identities = 66/290 (22%), Positives = 135/290 (46%), Gaps = 37/290 (12%)
Query: 336 QSQPAFLATNEEKCAREQIREATSERK---DLNIHVRDTKTVKDVQKAKNVNKTAEKVRI 392
+S L EEKC EA +R+ +L R K D K + ++K +++
Sbjct: 951 ESSAEKLRKMEEKC-ESAAHEADLKRQKVIELTGTARQVKIEMDQYK-EELSKMEKEIMH 1008
Query: 393 IKYLLGELKALVAEQEDSEIQRLITEMEA---CISVLPTVSGNTDIQVEIALAMQP---- 445
+K GE KA+ Q D + + TE+E + L + +T+ ++ AL +
Sbjct: 1009 LKRD-GENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLET 1067
Query: 446 -LRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQ 504
L++ + +L+ LR L + QK Q SL+ ++++ E + +
Sbjct: 1068 ELQNAHGELKSTLRQLQELRDVLQKAQ------------LSLEEKYTTIKDLTAELRECK 1115
Query: 505 ELLQSKNEELLKVIENQKDEN---KKFSSIFKDKDQTILENKQQYDIEITRIK------- 554
++ K +ELL++ + K+ N K+ ++ D TI E++ + + +I +++
Sbjct: 1116 MEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSE 1175
Query: 555 IELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRL-RELTRTLQ 603
+EL+E ++S KL+ A+++ + + Q + E+++L +E+ RT Q
Sbjct: 1176 LELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQ 1225
Score = 37.7 bits (86), Expect = 0.049
Identities = 71/337 (21%), Positives = 143/337 (42%), Gaps = 49/337 (14%)
Query: 356 EATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQ---EDSEI 412
EA E+KD ++ KT+ +Q+ ++ + + LL E K + ++ +D +
Sbjct: 774 EAQLEKKDQQFKEQE-KTMSMLQQ--DIICKQHHLESLDRLLTESKGEMKKENMKKDEAL 830
Query: 413 QRLITEM-EACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQ---LREQQ 468
+ L ++ E I V S + E+ L + L + +QL+ +++ L+++
Sbjct: 831 KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890
Query: 469 KTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQEL--LQSKNEELLKVIENQKDENK 526
K + S + +L Q +E++++ EL Q+K E+ + +E + + +
Sbjct: 891 KIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQR 950
Query: 527 KFSSIFKDKDQTILEN-------KQQYDIEIT----RIKIELEEALVNVKSSQFKLETAE 575
+ S+ K + E+ K+Q IE+T ++KIE++ Q+K E ++
Sbjct: 951 ESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMD---------QYKEELSK 1001
Query: 576 KENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKSLLNIHD 635
E +I+ + +RD E + + S ++ D + K N K L
Sbjct: 1002 MEKEIMHL---KRDGE-------NKAMHLSQLDMILDQTKTELEKK--TNAVKEL----- 1044
Query: 636 KQLQHDPAPAHTSIMSYLNKLETNYSFTHSEPLSTIK 672
++LQH T + LET H E ST++
Sbjct: 1045 EKLQHSTETELTEALQKREVLETELQNAHGELKSTLR 1081
Score = 37.0 bits (84), Expect = 0.084
Identities = 43/197 (21%), Positives = 90/197 (45%), Gaps = 10/197 (5%)
Query: 443 MQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLK 502
+ LR +NA L Q L + S A LE Q+ ++ + LEE +
Sbjct: 238 LNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPI---LEEQII 294
Query: 503 SQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALV 562
+ E S +++L+ EN+ ++++K + +K+Q++ E+K+ E ++K++L E
Sbjct: 295 NLEAEVSAQDKVLREAENKLEQSQK---MVIEKEQSLQESKE----ECIKLKVDLLEQTK 347
Query: 563 NVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKP 622
K ++ + A + L +Q +V E + + + + L++ ++ R +
Sbjct: 348 QGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQE 407
Query: 623 GNNLTKSLLNIHDKQLQ 639
L KS L I ++L+
Sbjct: 408 RCGLYKSELEILKEKLR 424
>gi|109659849 filamin A interacting protein 1-like isoform 2 [Homo
sapiens]
Length = 893
Score = 48.9 bits (115), Expect = 2e-05
Identities = 83/384 (21%), Positives = 159/384 (41%), Gaps = 44/384 (11%)
Query: 378 QKAKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQV 437
QK + + A++ K L E + ++E+ + RL E++ T + D Q
Sbjct: 18 QKIQELTTNAKETHT-KLALAEARV---QEEEQKATRLEKELQT-----QTTKFHQD-QD 67
Query: 438 EIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLE-----LFSLQSLNMS 492
I + S+N QL+++L L++Q+ E ++T + + L+ + + N
Sbjct: 68 TIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAG 127
Query: 493 LQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFS-SIFKDKDQTILENK-------- 543
+ ++EE K ++ K+EEL+K+ E +D NK+ + KD + K
Sbjct: 128 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 187
Query: 544 QQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQ 603
++ + + K E N++ + + +E + L + +++ +A +RL + TL+
Sbjct: 188 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLK 247
Query: 604 TSMAKL--LSDLSVDSARCKPGN-NLTKSLLNIHDKQLQHDPAPAHT-----------SI 649
+ KL L+ + VD + T+ L QLQ + T ++
Sbjct: 248 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRAL 307
Query: 650 MSYLNKLETNYSFTHSEPLSTIKNEETIEPDKTYENVLSSRGPQNSNTRGMEEASAPGII 709
S + E YS T +KN+ E +K N L SR N EA +
Sbjct: 308 KSKTDVEEKMYSVTKER--DDLKNKLKAEEEK--GNDLLSRVNMLKNRLQSLEAIEKDFL 363
Query: 710 SALSKQDSDEGSETMALIEDEHNL 733
+K + D G T AL ++ + +
Sbjct: 364 K--NKLNQDSGKSTTALHQENNKI 385
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 48.9 bits (115), Expect = 2e-05
Identities = 73/334 (21%), Positives = 141/334 (42%), Gaps = 41/334 (12%)
Query: 292 NGILPQQGIHKET-DLLKCIQTYLSLFRSHGKETHLDSQTHRSPTQSQPAFLATNEE--- 347
N + + HKET D LK T L+ + + + Q T + + +NE
Sbjct: 397 NKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQD-MIKTYQESEEIKSNELDAK 455
Query: 348 -KCAREQIREATSERKD-LNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVA 405
+ + ++ + E+ D L +H K ++D+++ + K E + L
Sbjct: 456 LRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRT 515
Query: 406 EQEDSEIQRLITEMEACI-SVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQL 464
E E S+ + +I +A I ++L V +Q ++ Q + + L+ ++ LN +
Sbjct: 516 EDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIEN----LKEEVESLNSLI 571
Query: 465 REQQKTQKPSGAVDCNLELFS---------LQSLNMSLQNQLEESLKSQELLQSKNEELL 515
+ QK + S + L LF+ LQS + SLQ+Q ++ S+ LQS+ E++
Sbjct: 572 NDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMK 631
Query: 516 KVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAE 575
+ N + K + K++ QT ++ EL VK+ ++E +
Sbjct: 632 QTNINLESRLLKEEELRKEEVQT--------------LQAELACRQTEVKALSTQVEELK 677
Query: 576 KENQILGITLRQRDAEVTRLRELTRTLQTSMAKL 609
E + QR + +++LT+ LQ + KL
Sbjct: 678 DE------LVTQRRKHASSIKDLTKQLQQARRKL 705
Score = 43.5 bits (101), Expect = 9e-04
Identities = 64/346 (18%), Positives = 145/346 (41%), Gaps = 19/346 (5%)
Query: 298 QGIHKETDLLKCIQTYLSLFRSHGKETHLDSQTHRSPTQSQPAF--LATNEEKCAREQIR 355
+G + DL K +T R KE ++ + +Q + L +E IR
Sbjct: 317 RGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIR 376
Query: 356 EATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRL 415
E ++D+N HV K ++ KA+ + K ++ + K A++E +I++
Sbjct: 377 EIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKE---TTTKLTQAKEEADQIRKN 433
Query: 416 ITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSG 475
+M + N ++ ++ + L + + QL + + +++E + ++
Sbjct: 434 CQDMIKTYQESEEIKSN-ELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKR--- 489
Query: 476 AVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDK 535
+ L++L ++ +E L++++ L E +I QK E + K
Sbjct: 490 --TFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKE----IINRQKAEIQNLLDKVKTA 543
Query: 536 DQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRL 595
DQ + E Q+ EI +K E+E + Q +E + K L + + ++ +L
Sbjct: 544 DQ-LQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQL 602
Query: 596 RELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKSLLNIHDKQLQHD 641
+ + +LQ+ K+ S ++C+ + ++ +N+ + L+ +
Sbjct: 603 QSESNSLQSQFDKVSCSESQLQSQCE---QMKQTNINLESRLLKEE 645
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.126 0.348
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,840,142
Number of Sequences: 37866
Number of extensions: 1549554
Number of successful extensions: 6606
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 547
Number of HSP's that attempted gapping in prelim test: 5438
Number of HSP's gapped (non-prelim): 1383
length of query: 912
length of database: 18,247,518
effective HSP length: 111
effective length of query: 801
effective length of database: 14,044,392
effective search space: 11249557992
effective search space used: 11249557992
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.