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Search of human proteins with 169403959
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169403959 ankyrin repeat domain 53 isoform a [Homo sapiens]
(530 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169403959 ankyrin repeat domain 53 isoform a [Homo sapiens] 1099 0.0
gi|169403957 ankyrin repeat domain 53 isoform b [Homo sapiens] 618 e-177
gi|70995241 ankyrin repeat domain 10 [Homo sapiens] 87 5e-17
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 77 3e-14
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 77 3e-14
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 77 3e-14
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 77 3e-14
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 77 3e-14
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 75 1e-13
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 75 1e-13
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 75 1e-13
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 75 1e-13
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 75 1e-13
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 75 1e-13
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 74 3e-13
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 74 3e-13
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 74 3e-13
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 72 1e-12
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 69 1e-11
gi|13129098 ankyrin repeat and SOCS box-containing 8 [Homo sapiens] 69 1e-11
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 69 1e-11
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 68 2e-11
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 67 5e-11
gi|34304381 inversin isoform a [Homo sapiens] 65 1e-10
gi|34304379 inversin isoform b [Homo sapiens] 65 1e-10
gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo sapi... 65 2e-10
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 65 2e-10
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 65 2e-10
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 64 3e-10
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 64 3e-10
>gi|169403959 ankyrin repeat domain 53 isoform a [Homo sapiens]
Length = 530
Score = 1099 bits (2843), Expect = 0.0
Identities = 530/530 (100%), Positives = 530/530 (100%)
Query: 1 MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPL 60
MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPL
Sbjct: 1 MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPL 60
Query: 61 PDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNV 120
PDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNV
Sbjct: 61 PDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNV 120
Query: 121 EWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHL 180
EWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHL
Sbjct: 121 EWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHL 180
Query: 181 VIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQ 240
VIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQ
Sbjct: 181 VIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQ 240
Query: 241 DAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEY 300
DAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEY
Sbjct: 241 DAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEY 300
Query: 301 QKEHKILREAAIRKWLHGKLHPGHSLVSNTKQARATALSKTPEQRESQRSRSFHPSVDAR 360
QKEHKILREAAIRKWLHGKLHPGHSLVSNTKQARATALSKTPEQRESQRSRSFHPSVDAR
Sbjct: 301 QKEHKILREAAIRKWLHGKLHPGHSLVSNTKQARATALSKTPEQRESQRSRSFHPSVDAR 360
Query: 361 LQCIPQPTEMPKPIYRKPTVKRPTMWNVSNNPARPPTTQISHSQGIRLGVHPDPTPEHDF 420
LQCIPQPTEMPKPIYRKPTVKRPTMWNVSNNPARPPTTQISHSQGIRLGVHPDPTPEHDF
Sbjct: 361 LQCIPQPTEMPKPIYRKPTVKRPTMWNVSNNPARPPTTQISHSQGIRLGVHPDPTPEHDF 420
Query: 421 SSFLEVRPDGHGGARLHTVDGHWVAPVPRLPFEVLLRMLYPRVWPYRMKVPQGFYPISMR 480
SSFLEVRPDGHGGARLHTVDGHWVAPVPRLPFEVLLRMLYPRVWPYRMKVPQGFYPISMR
Sbjct: 421 SSFLEVRPDGHGGARLHTVDGHWVAPVPRLPFEVLLRMLYPRVWPYRMKVPQGFYPISMR 480
Query: 481 EVPRKRHLGDNTFWTDTLAMNLRDTFDEAFLAAVRSHQGLPTLPSPQTNP 530
EVPRKRHLGDNTFWTDTLAMNLRDTFDEAFLAAVRSHQGLPTLPSPQTNP
Sbjct: 481 EVPRKRHLGDNTFWTDTLAMNLRDTFDEAFLAAVRSHQGLPTLPSPQTNP 530
>gi|169403957 ankyrin repeat domain 53 isoform b [Homo sapiens]
Length = 343
Score = 618 bits (1594), Expect = e-177
Identities = 301/301 (100%), Positives = 301/301 (100%)
Query: 1 MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPL 60
MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPL
Sbjct: 1 MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPL 60
Query: 61 PDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNV 120
PDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNV
Sbjct: 61 PDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNV 120
Query: 121 EWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHL 180
EWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHL
Sbjct: 121 EWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHL 180
Query: 181 VIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQ 240
VIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQ
Sbjct: 181 VIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQ 240
Query: 241 DAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEY 300
DAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEY
Sbjct: 241 DAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEY 300
Query: 301 Q 301
Q
Sbjct: 301 Q 301
>gi|70995241 ankyrin repeat domain 10 [Homo sapiens]
Length = 420
Score = 86.7 bits (213), Expect = 5e-17
Identities = 45/124 (36%), Positives = 68/124 (54%), Gaps = 4/124 (3%)
Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
G+T +H+AA +GKL CL LV T +QTP H+ + C+ +L++
Sbjct: 58 GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQ----CLVWLIQ 113
Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
GA++N C G TP+H AAR G L+C+ LV +GA+V ++A G D + + C
Sbjct: 114 AGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQEC 173
Query: 260 ARFL 263
A+FL
Sbjct: 174 AQFL 177
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 77.4 bits (189), Expect = 3e-14
Identities = 43/135 (31%), Positives = 72/135 (53%), Gaps = 5/135 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+VE + L + + KGFT +H AA++GK+ ++L+E P + N
Sbjct: 543 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP-NAAGKN 601
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ +H +N L + LL +G ++ NG TPLH+AA+ ++ + L+Q
Sbjct: 602 GLTPLHVAVHHNN----LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 657
Query: 234 GANVHAQDAMGYKPI 248
G + +A+ G P+
Sbjct: 658 GGSANAESVQGVTPL 672
Score = 68.9 bits (167), Expect = 1e-11
Identities = 44/143 (30%), Positives = 72/143 (50%), Gaps = 5/143 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+V L+ G + IH AAQ L C+++L++ Y +D +T +
Sbjct: 312 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ-YDAEIDDITLD 370
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ H + VA LL+KGA N++ NG TPLH+A + + +++L+++
Sbjct: 371 HLTPLHVAAHCGHHRVAK----VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 426
Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
GA++ A G P+ H
Sbjct: 427 GASIDAVTESGLTPLHVASFMGH 449
Score = 68.6 bits (166), Expect = 1e-11
Identities = 44/139 (31%), Positives = 71/139 (51%), Gaps = 5/139 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+ E + L++ + G T +H AQ G + VL++ + VD T
Sbjct: 675 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRM 733
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ H N + + +LL+ AD+NA+T G +PLH AA+ G D V +L+++
Sbjct: 734 GYTPLHVASHYGN----IKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 789
Query: 234 GANVHAQDAMGYKPIDFCK 252
GA+ + + G P+ K
Sbjct: 790 GASPNEVSSDGTTPLAIAK 808
Score = 68.2 bits (165), Expect = 2e-11
Identities = 41/124 (33%), Positives = 62/124 (50%), Gaps = 5/124 (4%)
Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
GFT +H AA + L Q+L+ V+ N TPLH+ R N + + LL+
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNRGA-SVNFTPQNGITPLHIASRRGNVIM----VRLLLD 293
Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
+GA + +T + TPLH AAR+G + ++L+ GA + A+ G PI +H C
Sbjct: 294 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 353
Query: 260 ARFL 263
R L
Sbjct: 354 VRLL 357
Score = 63.9 bits (154), Expect = 3e-10
Identities = 46/177 (25%), Positives = 82/177 (46%), Gaps = 13/177 (7%)
Query: 89 DPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAA 148
DP+P S +T I ++Y+ N+ + LN+ T G T +H A+
Sbjct: 229 DPNPDVLS-KTGFTPLHIAAHYE-------NLNVAQLLLNRGASVNFTPQNGITPLHIAS 280
Query: 149 QWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQT 208
+ G + +++L++ ++ T + TPLH + ++ LL+ GA + A+T
Sbjct: 281 RRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRIS----EILLDHGAPIQAKT 335
Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
NG +P+H+AA+ LDCV++L+Q A + P+ H A+ L D
Sbjct: 336 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 392
Score = 63.2 bits (152), Expect = 6e-10
Identities = 46/150 (30%), Positives = 66/150 (44%), Gaps = 5/150 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA +G+ ++ L + G T +H AA+ G + + L+E+ +T
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA-CMTKK 568
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ VA LLE+ A NA NG TPLH+A LD VK+L+
Sbjct: 569 GFTPLHVAAKYGKVRVA----ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 624
Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFL 263
G + H+ GY P+ N AR L
Sbjct: 625 GGSPHSPAWNGYTPLHIAAKQNQVEVARSL 654
Score = 58.9 bits (141), Expect = 1e-08
Identities = 36/111 (32%), Positives = 60/111 (54%), Gaps = 5/111 (4%)
Query: 138 DKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYL 197
+ G T +H A+ G L ++ L++ P ++ +TPLH+ +T VA YL
Sbjct: 435 ESGLTPLHVASFMGHLPIVKNLLQRGASP-NVSNVKVETPLHMAARAGHTEVAK----YL 489
Query: 198 LEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
L+ A +NA+ + TPLH AAR G + VK+L+++ AN + G+ P+
Sbjct: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 540
Score = 58.9 bits (141), Expect = 1e-08
Identities = 44/135 (32%), Positives = 67/135 (49%), Gaps = 5/135 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA VE R L +G T +H AAQ G + +L+ + + +L +
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKS 700
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLHLV + VA L++ G ++A T G TPLH+A+ G + VK L+Q
Sbjct: 701 GLTPLHLVAQEGHVPVA----DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 756
Query: 234 GANVHAQDAMGYKPI 248
A+V+A+ +GY P+
Sbjct: 757 QADVNAKTKLGYSPL 771
Score = 54.7 bits (130), Expect = 2e-07
Identities = 37/137 (27%), Positives = 67/137 (48%), Gaps = 5/137 (3%)
Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
L AA GN++ L + + G +H A++ G + + L+ + + ++ T
Sbjct: 50 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILETTT 108
Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
T LH+ V + Y GA++NAQ+ G TPL++AA++ L+ VK L+
Sbjct: 109 KKGNTALHIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLEVVKFLL 164
Query: 232 QSGANVHAQDAMGYKPI 248
++GAN + G+ P+
Sbjct: 165 ENGANQNVATEDGFTPL 181
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 4/97 (4%)
Query: 167 VDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDC 226
++ N LHL + + + LL K L T G+T LH+AA G +
Sbjct: 71 INTCNQNGLNGLHLASKEGHVKMVVE----LLHKEIILETTTKKGNTALHIAALAGQDEV 126
Query: 227 VKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
V+ LV GANV+AQ G+ P+ NH +FL
Sbjct: 127 VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 163
Score = 47.4 bits (111), Expect = 3e-05
Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 5/121 (4%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
A+ G+V+ + L++ + T KG TA+H AA G+ ++ LV Y V+ +
Sbjct: 85 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQK 143
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPL++ ++ V + +LLE GA+ N T +G TPL +A + G + V L+
Sbjct: 144 GFTPLYMAAQENHLEV----VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 199
Query: 234 G 234
G
Sbjct: 200 G 200
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/177 (24%), Positives = 71/177 (40%), Gaps = 26/177 (14%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G E +R +N KGFT ++ AAQ L ++ L+E ++ T +
Sbjct: 118 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ-NVATED 176
Query: 174 SQTPL-------------HLVIHRDNTTVALPCIYY------------LLEKGADLNAQT 208
TPL HL+ + V LP ++ LL+ + + +
Sbjct: 177 GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 236
Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
G TPLH+AA L+ ++L+ GA+V+ G P+ + R L D
Sbjct: 237 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 293
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 77.4 bits (189), Expect = 3e-14
Identities = 43/135 (31%), Positives = 72/135 (53%), Gaps = 5/135 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+VE + L + + KGFT +H AA++GK+ ++L+E P + N
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP-NAAGKN 568
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ +H +N L + LL +G ++ NG TPLH+AA+ ++ + L+Q
Sbjct: 569 GLTPLHVAVHHNN----LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 234 GANVHAQDAMGYKPI 248
G + +A+ G P+
Sbjct: 625 GGSANAESVQGVTPL 639
Score = 68.9 bits (167), Expect = 1e-11
Identities = 44/143 (30%), Positives = 72/143 (50%), Gaps = 5/143 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+V L+ G + IH AAQ L C+++L++ Y +D +T +
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ-YDAEIDDITLD 337
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ H + VA LL+KGA N++ NG TPLH+A + + +++L+++
Sbjct: 338 HLTPLHVAAHCGHHRVAK----VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
GA++ A G P+ H
Sbjct: 394 GASIDAVTESGLTPLHVASFMGH 416
Score = 68.6 bits (166), Expect = 1e-11
Identities = 44/139 (31%), Positives = 71/139 (51%), Gaps = 5/139 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+ E + L++ + G T +H AQ G + VL++ + VD T
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRM 700
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ H N + + +LL+ AD+NA+T G +PLH AA+ G D V +L+++
Sbjct: 701 GYTPLHVASHYGN----IKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 234 GANVHAQDAMGYKPIDFCK 252
GA+ + + G P+ K
Sbjct: 757 GASPNEVSSDGTTPLAIAK 775
Score = 68.2 bits (165), Expect = 2e-11
Identities = 41/124 (33%), Positives = 62/124 (50%), Gaps = 5/124 (4%)
Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
GFT +H AA + L Q+L+ V+ N TPLH+ R N + + LL+
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGA-SVNFTPQNGITPLHIASRRGNVIM----VRLLLD 260
Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
+GA + +T + TPLH AAR+G + ++L+ GA + A+ G PI +H C
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 260 ARFL 263
R L
Sbjct: 321 VRLL 324
Score = 63.9 bits (154), Expect = 3e-10
Identities = 46/177 (25%), Positives = 82/177 (46%), Gaps = 13/177 (7%)
Query: 89 DPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAA 148
DP+P S +T I ++Y+ N+ + LN+ T G T +H A+
Sbjct: 196 DPNPDVLS-KTGFTPLHIAAHYE-------NLNVAQLLLNRGASVNFTPQNGITPLHIAS 247
Query: 149 QWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQT 208
+ G + +++L++ ++ T + TPLH + ++ LL+ GA + A+T
Sbjct: 248 RRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRIS----EILLDHGAPIQAKT 302
Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
NG +P+H+AA+ LDCV++L+Q A + P+ H A+ L D
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Score = 63.2 bits (152), Expect = 6e-10
Identities = 46/150 (30%), Positives = 66/150 (44%), Gaps = 5/150 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA +G+ ++ L + G T +H AA+ G + + L+E+ +T
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA-CMTKK 535
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ VA LLE+ A NA NG TPLH+A LD VK+L+
Sbjct: 536 GFTPLHVAAKYGKVRVA----ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 591
Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFL 263
G + H+ GY P+ N AR L
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Score = 58.9 bits (141), Expect = 1e-08
Identities = 36/111 (32%), Positives = 60/111 (54%), Gaps = 5/111 (4%)
Query: 138 DKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYL 197
+ G T +H A+ G L ++ L++ P ++ +TPLH+ +T VA YL
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASP-NVSNVKVETPLHMAARAGHTEVAK----YL 456
Query: 198 LEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
L+ A +NA+ + TPLH AAR G + VK+L+++ AN + G+ P+
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507
Score = 58.9 bits (141), Expect = 1e-08
Identities = 44/135 (32%), Positives = 67/135 (49%), Gaps = 5/135 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA VE R L +G T +H AAQ G + +L+ + + +L +
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKS 667
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLHLV + VA L++ G ++A T G TPLH+A+ G + VK L+Q
Sbjct: 668 GLTPLHLVAQEGHVPVA----DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 234 GANVHAQDAMGYKPI 248
A+V+A+ +GY P+
Sbjct: 724 QADVNAKTKLGYSPL 738
Score = 54.7 bits (130), Expect = 2e-07
Identities = 37/137 (27%), Positives = 67/137 (48%), Gaps = 5/137 (3%)
Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
L AA GN++ L + + G +H A++ G + + L+ + + ++ T
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILETTT 75
Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
T LH+ V + Y GA++NAQ+ G TPL++AA++ L+ VK L+
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Query: 232 QSGANVHAQDAMGYKPI 248
++GAN + G+ P+
Sbjct: 132 ENGANQNVATEDGFTPL 148
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 4/97 (4%)
Query: 167 VDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDC 226
++ N LHL + + + LL K L T G+T LH+AA G +
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVE----LLHKEIILETTTKKGNTALHIAALAGQDEV 93
Query: 227 VKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
V+ LV GANV+AQ G+ P+ NH +FL
Sbjct: 94 VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Score = 47.4 bits (111), Expect = 3e-05
Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 5/121 (4%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
A+ G+V+ + L++ + T KG TA+H AA G+ ++ LV Y V+ +
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQK 110
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPL++ ++ V + +LLE GA+ N T +G TPL +A + G + V L+
Sbjct: 111 GFTPLYMAAQENHLEV----VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 234 G 234
G
Sbjct: 167 G 167
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/177 (24%), Positives = 71/177 (40%), Gaps = 26/177 (14%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G E +R +N KGFT ++ AAQ L ++ L+E ++ T +
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ-NVATED 143
Query: 174 SQTPL-------------HLVIHRDNTTVALPCIYY------------LLEKGADLNAQT 208
TPL HL+ + V LP ++ LL+ + + +
Sbjct: 144 GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203
Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
G TPLH+AA L+ ++L+ GA+V+ G P+ + R L D
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 77.4 bits (189), Expect = 3e-14
Identities = 43/135 (31%), Positives = 72/135 (53%), Gaps = 5/135 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+VE + L + + KGFT +H AA++GK+ ++L+E P + N
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP-NAAGKN 568
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ +H +N L + LL +G ++ NG TPLH+AA+ ++ + L+Q
Sbjct: 569 GLTPLHVAVHHNN----LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 234 GANVHAQDAMGYKPI 248
G + +A+ G P+
Sbjct: 625 GGSANAESVQGVTPL 639
Score = 68.9 bits (167), Expect = 1e-11
Identities = 44/143 (30%), Positives = 72/143 (50%), Gaps = 5/143 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+V L+ G + IH AAQ L C+++L++ Y +D +T +
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ-YDAEIDDITLD 337
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ H + VA LL+KGA N++ NG TPLH+A + + +++L+++
Sbjct: 338 HLTPLHVAAHCGHHRVAK----VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
GA++ A G P+ H
Sbjct: 394 GASIDAVTESGLTPLHVASFMGH 416
Score = 68.6 bits (166), Expect = 1e-11
Identities = 44/139 (31%), Positives = 71/139 (51%), Gaps = 5/139 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+ E + L++ + G T +H AQ G + VL++ + VD T
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRM 700
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ H N + + +LL+ AD+NA+T G +PLH AA+ G D V +L+++
Sbjct: 701 GYTPLHVASHYGN----IKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 234 GANVHAQDAMGYKPIDFCK 252
GA+ + + G P+ K
Sbjct: 757 GASPNEVSSDGTTPLAIAK 775
Score = 68.2 bits (165), Expect = 2e-11
Identities = 41/124 (33%), Positives = 62/124 (50%), Gaps = 5/124 (4%)
Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
GFT +H AA + L Q+L+ V+ N TPLH+ R N + + LL+
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGA-SVNFTPQNGITPLHIASRRGNVIM----VRLLLD 260
Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
+GA + +T + TPLH AAR+G + ++L+ GA + A+ G PI +H C
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 260 ARFL 263
R L
Sbjct: 321 VRLL 324
Score = 63.9 bits (154), Expect = 3e-10
Identities = 46/177 (25%), Positives = 82/177 (46%), Gaps = 13/177 (7%)
Query: 89 DPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAA 148
DP+P S +T I ++Y+ N+ + LN+ T G T +H A+
Sbjct: 196 DPNPDVLS-KTGFTPLHIAAHYE-------NLNVAQLLLNRGASVNFTPQNGITPLHIAS 247
Query: 149 QWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQT 208
+ G + +++L++ ++ T + TPLH + ++ LL+ GA + A+T
Sbjct: 248 RRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRIS----EILLDHGAPIQAKT 302
Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
NG +P+H+AA+ LDCV++L+Q A + P+ H A+ L D
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Score = 63.2 bits (152), Expect = 6e-10
Identities = 46/150 (30%), Positives = 66/150 (44%), Gaps = 5/150 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA +G+ ++ L + G T +H AA+ G + + L+E+ +T
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA-CMTKK 535
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ VA LLE+ A NA NG TPLH+A LD VK+L+
Sbjct: 536 GFTPLHVAAKYGKVRVA----ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 591
Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFL 263
G + H+ GY P+ N AR L
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Score = 58.9 bits (141), Expect = 1e-08
Identities = 36/111 (32%), Positives = 60/111 (54%), Gaps = 5/111 (4%)
Query: 138 DKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYL 197
+ G T +H A+ G L ++ L++ P ++ +TPLH+ +T VA YL
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASP-NVSNVKVETPLHMAARAGHTEVAK----YL 456
Query: 198 LEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
L+ A +NA+ + TPLH AAR G + VK+L+++ AN + G+ P+
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507
Score = 58.9 bits (141), Expect = 1e-08
Identities = 44/135 (32%), Positives = 67/135 (49%), Gaps = 5/135 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA VE R L +G T +H AAQ G + +L+ + + +L +
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKS 667
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLHLV + VA L++ G ++A T G TPLH+A+ G + VK L+Q
Sbjct: 668 GLTPLHLVAQEGHVPVA----DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 234 GANVHAQDAMGYKPI 248
A+V+A+ +GY P+
Sbjct: 724 QADVNAKTKLGYSPL 738
Score = 54.7 bits (130), Expect = 2e-07
Identities = 37/137 (27%), Positives = 67/137 (48%), Gaps = 5/137 (3%)
Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
L AA GN++ L + + G +H A++ G + + L+ + + ++ T
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILETTT 75
Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
T LH+ V + Y GA++NAQ+ G TPL++AA++ L+ VK L+
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Query: 232 QSGANVHAQDAMGYKPI 248
++GAN + G+ P+
Sbjct: 132 ENGANQNVATEDGFTPL 148
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 4/97 (4%)
Query: 167 VDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDC 226
++ N LHL + + + LL K L T G+T LH+AA G +
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVE----LLHKEIILETTTKKGNTALHIAALAGQDEV 93
Query: 227 VKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
V+ LV GANV+AQ G+ P+ NH +FL
Sbjct: 94 VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Score = 47.4 bits (111), Expect = 3e-05
Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 5/121 (4%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
A+ G+V+ + L++ + T KG TA+H AA G+ ++ LV Y V+ +
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQK 110
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPL++ ++ V + +LLE GA+ N T +G TPL +A + G + V L+
Sbjct: 111 GFTPLYMAAQENHLEV----VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 234 G 234
G
Sbjct: 167 G 167
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/177 (24%), Positives = 71/177 (40%), Gaps = 26/177 (14%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G E +R +N KGFT ++ AAQ L ++ L+E ++ T +
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ-NVATED 143
Query: 174 SQTPL-------------HLVIHRDNTTVALPCIYY------------LLEKGADLNAQT 208
TPL HL+ + V LP ++ LL+ + + +
Sbjct: 144 GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203
Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
G TPLH+AA L+ ++L+ GA+V+ G P+ + R L D
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 77.4 bits (189), Expect = 3e-14
Identities = 43/135 (31%), Positives = 72/135 (53%), Gaps = 5/135 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+VE + L + + KGFT +H AA++GK+ ++L+E P + N
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP-NAAGKN 568
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ +H +N L + LL +G ++ NG TPLH+AA+ ++ + L+Q
Sbjct: 569 GLTPLHVAVHHNN----LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 234 GANVHAQDAMGYKPI 248
G + +A+ G P+
Sbjct: 625 GGSANAESVQGVTPL 639
Score = 68.9 bits (167), Expect = 1e-11
Identities = 44/143 (30%), Positives = 72/143 (50%), Gaps = 5/143 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+V L+ G + IH AAQ L C+++L++ Y +D +T +
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ-YDAEIDDITLD 337
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ H + VA LL+KGA N++ NG TPLH+A + + +++L+++
Sbjct: 338 HLTPLHVAAHCGHHRVAK----VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
GA++ A G P+ H
Sbjct: 394 GASIDAVTESGLTPLHVASFMGH 416
Score = 68.6 bits (166), Expect = 1e-11
Identities = 44/139 (31%), Positives = 71/139 (51%), Gaps = 5/139 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+ E + L++ + G T +H AQ G + VL++ + VD T
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRM 700
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ H N + + +LL+ AD+NA+T G +PLH AA+ G D V +L+++
Sbjct: 701 GYTPLHVASHYGN----IKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 234 GANVHAQDAMGYKPIDFCK 252
GA+ + + G P+ K
Sbjct: 757 GASPNEVSSDGTTPLAIAK 775
Score = 68.2 bits (165), Expect = 2e-11
Identities = 41/124 (33%), Positives = 62/124 (50%), Gaps = 5/124 (4%)
Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
GFT +H AA + L Q+L+ V+ N TPLH+ R N + + LL+
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGA-SVNFTPQNGITPLHIASRRGNVIM----VRLLLD 260
Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
+GA + +T + TPLH AAR+G + ++L+ GA + A+ G PI +H C
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 260 ARFL 263
R L
Sbjct: 321 VRLL 324
Score = 63.9 bits (154), Expect = 3e-10
Identities = 46/177 (25%), Positives = 82/177 (46%), Gaps = 13/177 (7%)
Query: 89 DPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAA 148
DP+P S +T I ++Y+ N+ + LN+ T G T +H A+
Sbjct: 196 DPNPDVLS-KTGFTPLHIAAHYE-------NLNVAQLLLNRGASVNFTPQNGITPLHIAS 247
Query: 149 QWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQT 208
+ G + +++L++ ++ T + TPLH + ++ LL+ GA + A+T
Sbjct: 248 RRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRIS----EILLDHGAPIQAKT 302
Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
NG +P+H+AA+ LDCV++L+Q A + P+ H A+ L D
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Score = 63.2 bits (152), Expect = 6e-10
Identities = 46/150 (30%), Positives = 66/150 (44%), Gaps = 5/150 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA +G+ ++ L + G T +H AA+ G + + L+E+ +T
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA-CMTKK 535
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ VA LLE+ A NA NG TPLH+A LD VK+L+
Sbjct: 536 GFTPLHVAAKYGKVRVA----ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 591
Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFL 263
G + H+ GY P+ N AR L
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Score = 58.9 bits (141), Expect = 1e-08
Identities = 36/111 (32%), Positives = 60/111 (54%), Gaps = 5/111 (4%)
Query: 138 DKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYL 197
+ G T +H A+ G L ++ L++ P ++ +TPLH+ +T VA YL
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASP-NVSNVKVETPLHMAARAGHTEVAK----YL 456
Query: 198 LEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
L+ A +NA+ + TPLH AAR G + VK+L+++ AN + G+ P+
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507
Score = 58.9 bits (141), Expect = 1e-08
Identities = 44/135 (32%), Positives = 67/135 (49%), Gaps = 5/135 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA VE R L +G T +H AAQ G + +L+ + + +L +
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKS 667
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLHLV + VA L++ G ++A T G TPLH+A+ G + VK L+Q
Sbjct: 668 GLTPLHLVAQEGHVPVA----DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 234 GANVHAQDAMGYKPI 248
A+V+A+ +GY P+
Sbjct: 724 QADVNAKTKLGYSPL 738
Score = 54.7 bits (130), Expect = 2e-07
Identities = 37/137 (27%), Positives = 67/137 (48%), Gaps = 5/137 (3%)
Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
L AA GN++ L + + G +H A++ G + + L+ + + ++ T
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILETTT 75
Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
T LH+ V + Y GA++NAQ+ G TPL++AA++ L+ VK L+
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Query: 232 QSGANVHAQDAMGYKPI 248
++GAN + G+ P+
Sbjct: 132 ENGANQNVATEDGFTPL 148
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 4/97 (4%)
Query: 167 VDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDC 226
++ N LHL + + + LL K L T G+T LH+AA G +
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVE----LLHKEIILETTTKKGNTALHIAALAGQDEV 93
Query: 227 VKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
V+ LV GANV+AQ G+ P+ NH +FL
Sbjct: 94 VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Score = 47.4 bits (111), Expect = 3e-05
Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 5/121 (4%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
A+ G+V+ + L++ + T KG TA+H AA G+ ++ LV Y V+ +
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQK 110
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPL++ ++ V + +LLE GA+ N T +G TPL +A + G + V L+
Sbjct: 111 GFTPLYMAAQENHLEV----VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 234 G 234
G
Sbjct: 167 G 167
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/177 (24%), Positives = 71/177 (40%), Gaps = 26/177 (14%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G E +R +N KGFT ++ AAQ L ++ L+E ++ T +
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ-NVATED 143
Query: 174 SQTPL-------------HLVIHRDNTTVALPCIYY------------LLEKGADLNAQT 208
TPL HL+ + V LP ++ LL+ + + +
Sbjct: 144 GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203
Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
G TPLH+AA L+ ++L+ GA+V+ G P+ + R L D
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 77.4 bits (189), Expect = 3e-14
Identities = 43/135 (31%), Positives = 72/135 (53%), Gaps = 5/135 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+VE + L + + KGFT +H AA++GK+ ++L+E P + N
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP-NAAGKN 568
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ +H +N L + LL +G ++ NG TPLH+AA+ ++ + L+Q
Sbjct: 569 GLTPLHVAVHHNN----LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 234 GANVHAQDAMGYKPI 248
G + +A+ G P+
Sbjct: 625 GGSANAESVQGVTPL 639
Score = 68.9 bits (167), Expect = 1e-11
Identities = 44/143 (30%), Positives = 72/143 (50%), Gaps = 5/143 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+V L+ G + IH AAQ L C+++L++ Y +D +T +
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ-YDAEIDDITLD 337
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ H + VA LL+KGA N++ NG TPLH+A + + +++L+++
Sbjct: 338 HLTPLHVAAHCGHHRVAK----VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
GA++ A G P+ H
Sbjct: 394 GASIDAVTESGLTPLHVASFMGH 416
Score = 68.6 bits (166), Expect = 1e-11
Identities = 44/139 (31%), Positives = 71/139 (51%), Gaps = 5/139 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+ E + L++ + G T +H AQ G + VL++ + VD T
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRM 700
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ H N + + +LL+ AD+NA+T G +PLH AA+ G D V +L+++
Sbjct: 701 GYTPLHVASHYGN----IKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 234 GANVHAQDAMGYKPIDFCK 252
GA+ + + G P+ K
Sbjct: 757 GASPNEVSSDGTTPLAIAK 775
Score = 68.2 bits (165), Expect = 2e-11
Identities = 41/124 (33%), Positives = 62/124 (50%), Gaps = 5/124 (4%)
Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
GFT +H AA + L Q+L+ V+ N TPLH+ R N + + LL+
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGA-SVNFTPQNGITPLHIASRRGNVIM----VRLLLD 260
Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
+GA + +T + TPLH AAR+G + ++L+ GA + A+ G PI +H C
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 260 ARFL 263
R L
Sbjct: 321 VRLL 324
Score = 63.9 bits (154), Expect = 3e-10
Identities = 46/177 (25%), Positives = 82/177 (46%), Gaps = 13/177 (7%)
Query: 89 DPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAA 148
DP+P S +T I ++Y+ N+ + LN+ T G T +H A+
Sbjct: 196 DPNPDVLS-KTGFTPLHIAAHYE-------NLNVAQLLLNRGASVNFTPQNGITPLHIAS 247
Query: 149 QWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQT 208
+ G + +++L++ ++ T + TPLH + ++ LL+ GA + A+T
Sbjct: 248 RRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRIS----EILLDHGAPIQAKT 302
Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
NG +P+H+AA+ LDCV++L+Q A + P+ H A+ L D
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Score = 63.2 bits (152), Expect = 6e-10
Identities = 46/150 (30%), Positives = 66/150 (44%), Gaps = 5/150 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA +G+ ++ L + G T +H AA+ G + + L+E+ +T
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA-CMTKK 535
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ VA LLE+ A NA NG TPLH+A LD VK+L+
Sbjct: 536 GFTPLHVAAKYGKVRVA----ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 591
Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFL 263
G + H+ GY P+ N AR L
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Score = 58.9 bits (141), Expect = 1e-08
Identities = 36/111 (32%), Positives = 60/111 (54%), Gaps = 5/111 (4%)
Query: 138 DKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYL 197
+ G T +H A+ G L ++ L++ P ++ +TPLH+ +T VA YL
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASP-NVSNVKVETPLHMAARAGHTEVAK----YL 456
Query: 198 LEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
L+ A +NA+ + TPLH AAR G + VK+L+++ AN + G+ P+
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507
Score = 58.9 bits (141), Expect = 1e-08
Identities = 44/135 (32%), Positives = 67/135 (49%), Gaps = 5/135 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA VE R L +G T +H AAQ G + +L+ + + +L +
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKS 667
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLHLV + VA L++ G ++A T G TPLH+A+ G + VK L+Q
Sbjct: 668 GLTPLHLVAQEGHVPVA----DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 234 GANVHAQDAMGYKPI 248
A+V+A+ +GY P+
Sbjct: 724 QADVNAKTKLGYSPL 738
Score = 54.7 bits (130), Expect = 2e-07
Identities = 37/137 (27%), Positives = 67/137 (48%), Gaps = 5/137 (3%)
Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
L AA GN++ L + + G +H A++ G + + L+ + + ++ T
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILETTT 75
Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
T LH+ V + Y GA++NAQ+ G TPL++AA++ L+ VK L+
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Query: 232 QSGANVHAQDAMGYKPI 248
++GAN + G+ P+
Sbjct: 132 ENGANQNVATEDGFTPL 148
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 4/97 (4%)
Query: 167 VDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDC 226
++ N LHL + + + LL K L T G+T LH+AA G +
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVE----LLHKEIILETTTKKGNTALHIAALAGQDEV 93
Query: 227 VKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
V+ LV GANV+AQ G+ P+ NH +FL
Sbjct: 94 VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Score = 47.4 bits (111), Expect = 3e-05
Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 5/121 (4%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
A+ G+V+ + L++ + T KG TA+H AA G+ ++ LV Y V+ +
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQK 110
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPL++ ++ V + +LLE GA+ N T +G TPL +A + G + V L+
Sbjct: 111 GFTPLYMAAQENHLEV----VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 234 G 234
G
Sbjct: 167 G 167
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/177 (24%), Positives = 71/177 (40%), Gaps = 26/177 (14%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G E +R +N KGFT ++ AAQ L ++ L+E ++ T +
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ-NVATED 143
Query: 174 SQTPL-------------HLVIHRDNTTVALPCIYY------------LLEKGADLNAQT 208
TPL HL+ + V LP ++ LL+ + + +
Sbjct: 144 GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203
Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
G TPLH+AA L+ ++L+ GA+V+ G P+ + R L D
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 75.5 bits (184), Expect = 1e-13
Identities = 48/157 (30%), Positives = 83/157 (52%), Gaps = 7/157 (4%)
Query: 97 DQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACL 156
D TA D T + + AA + E +R L D G TA+H+AA G L +
Sbjct: 81 DVTAQDTTGHSALH--LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 138
Query: 157 QVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLH 216
Q+L E +K P++L + PL L + ++ + ++LL+ GAD+N++ +G T L
Sbjct: 139 QILCE-HKSPINLKDLDGNIPLLLAVQNGHSEIC----HFLLDHGADVNSRNKSGRTALM 193
Query: 217 LAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKI 253
LA G + V+ L++ GA+++ D++GY + + K+
Sbjct: 194 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 230
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/129 (28%), Positives = 56/129 (43%), Gaps = 5/129 (3%)
Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
D +G TA H AA G + CL+V++ VD+ + T H +H CI
Sbjct: 53 DSEGKTAFHLAAAKGHVECLRVMITH---GVDVTAQD--TTGHSALHLAAKNSHHECIRK 107
Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
LL+ + +G T LH AA G L V++L + + ++ +D G P+ H
Sbjct: 108 LLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH 167
Query: 257 RACARFLKD 265
FL D
Sbjct: 168 SEICHFLLD 176
Score = 47.0 bits (110), Expect = 4e-05
Identities = 22/65 (33%), Positives = 33/65 (50%)
Query: 199 EKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRA 258
+KGA G T HLAA G ++C++V++ G +V AQD G+ + +H
Sbjct: 44 KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 103
Query: 259 CARFL 263
C R L
Sbjct: 104 CIRKL 108
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 75.5 bits (184), Expect = 1e-13
Identities = 48/157 (30%), Positives = 83/157 (52%), Gaps = 7/157 (4%)
Query: 97 DQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACL 156
D TA D T + + AA + E +R L D G TA+H+AA G L +
Sbjct: 70 DVTAQDTTGHSALH--LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 127
Query: 157 QVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLH 216
Q+L E +K P++L + PL L + ++ + ++LL+ GAD+N++ +G T L
Sbjct: 128 QILCE-HKSPINLKDLDGNIPLLLAVQNGHSEIC----HFLLDHGADVNSRNKSGRTALM 182
Query: 217 LAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKI 253
LA G + V+ L++ GA+++ D++GY + + K+
Sbjct: 183 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 219
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/129 (28%), Positives = 56/129 (43%), Gaps = 5/129 (3%)
Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
D +G TA H AA G + CL+V++ VD+ + T H +H CI
Sbjct: 42 DSEGKTAFHLAAAKGHVECLRVMITH---GVDVTAQD--TTGHSALHLAAKNSHHECIRK 96
Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
LL+ + +G T LH AA G L V++L + + ++ +D G P+ H
Sbjct: 97 LLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH 156
Query: 257 RACARFLKD 265
FL D
Sbjct: 157 SEICHFLLD 165
Score = 47.0 bits (110), Expect = 4e-05
Identities = 22/65 (33%), Positives = 33/65 (50%)
Query: 199 EKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRA 258
+KGA G T HLAA G ++C++V++ G +V AQD G+ + +H
Sbjct: 33 KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 92
Query: 259 CARFL 263
C R L
Sbjct: 93 CIRKL 97
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 75.5 bits (184), Expect = 1e-13
Identities = 48/157 (30%), Positives = 83/157 (52%), Gaps = 7/157 (4%)
Query: 97 DQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACL 156
D TA D T + + AA + E +R L D G TA+H+AA G L +
Sbjct: 78 DVTAQDTTGHSALH--LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135
Query: 157 QVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLH 216
Q+L E +K P++L + PL L + ++ + ++LL+ GAD+N++ +G T L
Sbjct: 136 QILCE-HKSPINLKDLDGNIPLLLAVQNGHSEIC----HFLLDHGADVNSRNKSGRTALM 190
Query: 217 LAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKI 253
LA G + V+ L++ GA+++ D++GY + + K+
Sbjct: 191 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 227
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/129 (28%), Positives = 56/129 (43%), Gaps = 5/129 (3%)
Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
D +G TA H AA G + CL+V++ VD+ + T H +H CI
Sbjct: 50 DSEGKTAFHLAAAKGHVECLRVMITH---GVDVTAQD--TTGHSALHLAAKNSHHECIRK 104
Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
LL+ + +G T LH AA G L V++L + + ++ +D G P+ H
Sbjct: 105 LLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH 164
Query: 257 RACARFLKD 265
FL D
Sbjct: 165 SEICHFLLD 173
Score = 47.0 bits (110), Expect = 4e-05
Identities = 22/65 (33%), Positives = 33/65 (50%)
Query: 199 EKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRA 258
+KGA G T HLAA G ++C++V++ G +V AQD G+ + +H
Sbjct: 41 KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 100
Query: 259 CARFL 263
C R L
Sbjct: 101 CIRKL 105
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 75.5 bits (184), Expect = 1e-13
Identities = 48/157 (30%), Positives = 83/157 (52%), Gaps = 7/157 (4%)
Query: 97 DQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACL 156
D TA D T + + AA + E +R L D G TA+H+AA G L +
Sbjct: 78 DVTAQDTTGHSALH--LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135
Query: 157 QVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLH 216
Q+L E +K P++L + PL L + ++ + ++LL+ GAD+N++ +G T L
Sbjct: 136 QILCE-HKSPINLKDLDGNIPLLLAVQNGHSEIC----HFLLDHGADVNSRNKSGRTALM 190
Query: 217 LAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKI 253
LA G + V+ L++ GA+++ D++GY + + K+
Sbjct: 191 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 227
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/129 (28%), Positives = 56/129 (43%), Gaps = 5/129 (3%)
Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
D +G TA H AA G + CL+V++ VD+ + T H +H CI
Sbjct: 50 DSEGKTAFHLAAAKGHVECLRVMITH---GVDVTAQD--TTGHSALHLAAKNSHHECIRK 104
Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
LL+ + +G T LH AA G L V++L + + ++ +D G P+ H
Sbjct: 105 LLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH 164
Query: 257 RACARFLKD 265
FL D
Sbjct: 165 SEICHFLLD 173
Score = 47.0 bits (110), Expect = 4e-05
Identities = 22/65 (33%), Positives = 33/65 (50%)
Query: 199 EKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRA 258
+KGA G T HLAA G ++C++V++ G +V AQD G+ + +H
Sbjct: 41 KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 100
Query: 259 CARFL 263
C R L
Sbjct: 101 CIRKL 105
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 75.5 bits (184), Expect = 1e-13
Identities = 48/157 (30%), Positives = 83/157 (52%), Gaps = 7/157 (4%)
Query: 97 DQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACL 156
D TA D T + + AA + E +R L D G TA+H+AA G L +
Sbjct: 78 DVTAQDTTGHSALH--LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135
Query: 157 QVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLH 216
Q+L E +K P++L + PL L + ++ + ++LL+ GAD+N++ +G T L
Sbjct: 136 QILCE-HKSPINLKDLDGNIPLLLAVQNGHSEIC----HFLLDHGADVNSRNKSGRTALM 190
Query: 217 LAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKI 253
LA G + V+ L++ GA+++ D++GY + + K+
Sbjct: 191 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 227
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/129 (28%), Positives = 56/129 (43%), Gaps = 5/129 (3%)
Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
D +G TA H AA G + CL+V++ VD+ + T H +H CI
Sbjct: 50 DSEGKTAFHLAAAKGHVECLRVMITH---GVDVTAQD--TTGHSALHLAAKNSHHECIRK 104
Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
LL+ + +G T LH AA G L V++L + + ++ +D G P+ H
Sbjct: 105 LLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH 164
Query: 257 RACARFLKD 265
FL D
Sbjct: 165 SEICHFLLD 173
Score = 47.0 bits (110), Expect = 4e-05
Identities = 22/65 (33%), Positives = 33/65 (50%)
Query: 199 EKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRA 258
+KGA G T HLAA G ++C++V++ G +V AQD G+ + +H
Sbjct: 41 KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 100
Query: 259 CARFL 263
C R L
Sbjct: 101 CIRKL 105
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 75.5 bits (184), Expect = 1e-13
Identities = 48/157 (30%), Positives = 83/157 (52%), Gaps = 7/157 (4%)
Query: 97 DQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACL 156
D TA D T + + AA + E +R L D G TA+H+AA G L +
Sbjct: 78 DVTAQDTTGHSALH--LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135
Query: 157 QVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLH 216
Q+L E +K P++L + PL L + ++ + ++LL+ GAD+N++ +G T L
Sbjct: 136 QILCE-HKSPINLKDLDGNIPLLLAVQNGHSEIC----HFLLDHGADVNSRNKSGRTALM 190
Query: 217 LAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKI 253
LA G + V+ L++ GA+++ D++GY + + K+
Sbjct: 191 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 227
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/129 (28%), Positives = 56/129 (43%), Gaps = 5/129 (3%)
Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
D +G TA H AA G + CL+V++ VD+ + T H +H CI
Sbjct: 50 DSEGKTAFHLAAAKGHVECLRVMITH---GVDVTAQD--TTGHSALHLAAKNSHHECIRK 104
Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
LL+ + +G T LH AA G L V++L + + ++ +D G P+ H
Sbjct: 105 LLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH 164
Query: 257 RACARFLKD 265
FL D
Sbjct: 165 SEICHFLLD 173
Score = 47.0 bits (110), Expect = 4e-05
Identities = 22/65 (33%), Positives = 33/65 (50%)
Query: 199 EKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRA 258
+KGA G T HLAA G ++C++V++ G +V AQD G+ + +H
Sbjct: 41 KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 100
Query: 259 CARFL 263
C R L
Sbjct: 101 CIRKL 105
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 74.3 bits (181), Expect = 3e-13
Identities = 49/152 (32%), Positives = 67/152 (44%), Gaps = 5/152 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
+A G V+ L KGFT +H AA++G L ++L++ + D N
Sbjct: 516 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR-RAAADSAGKN 574
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ H DN VAL LLEKGA +A NG TPLH+AA+ + L+
Sbjct: 575 GLTPLHVAAHYDNQKVAL----LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 630
Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
GA + G P+ H L D
Sbjct: 631 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 662
Score = 73.9 bits (180), Expect = 3e-13
Identities = 43/128 (33%), Positives = 67/128 (52%), Gaps = 5/128 (3%)
Query: 136 TDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIY 195
T + GFT +H AA +G + +L+ VD N TPLH+ R NT + +
Sbjct: 208 TTESGFTPLHIAAHYGNVNVATLLLNRGA-AVDFTARNGITPLHVASKRGNTNM----VK 262
Query: 196 YLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWN 255
LL++G ++A+T +G TPLH AAR G V++L++ GA + A+ G P+ +
Sbjct: 263 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 322
Query: 256 HRACARFL 263
H C + L
Sbjct: 323 HVECVKHL 330
Score = 67.0 bits (162), Expect = 4e-11
Identities = 62/233 (26%), Positives = 107/233 (45%), Gaps = 9/233 (3%)
Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
L AA GN++ + L + + G A+H AA+ G + +Q L+ VD T
Sbjct: 15 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS-SVDSAT 73
Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
T LH+ V + L+++GA++NAQ+ NG TPL++AA++ +D VK L+
Sbjct: 74 KKGNTALHIASLAGQAEV----VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 129
Query: 232 QSGANVHAQDAMGYKPIDFCKIWNH-RACARFLKDAMWKKDKKDFAREMTKMKMFKSQLT 290
++GAN G+ P+ H +A A L++ K + + KS
Sbjct: 130 ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAAL 189
Query: 291 LMEHNYLIEYQKEHKILR--EAAIRKWLHGKLHPGHSLVSNTKQARATALSKT 341
L+++++ + Q + + R E+ LH H G+ V+ R A+ T
Sbjct: 190 LLQNDHNADVQSKMMVNRTTESGFTP-LHIAAHYGNVNVATLLLNRGAAVDFT 241
Score = 66.6 bits (161), Expect = 5e-11
Identities = 42/135 (31%), Positives = 69/135 (51%), Gaps = 5/135 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA +G++ + L T+ +G TA+H AA+ G++ ++ L+ VD
Sbjct: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL-VDARARE 475
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
QTPLH+ T + + LL+ A +A T NG TPLH++AR+G +D VL+++
Sbjct: 476 EQTPLHIASRLGKTEI----VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 531
Query: 234 GANVHAQDAMGYKPI 248
GA G+ P+
Sbjct: 532 GAAHSLATKKGFTPL 546
Score = 66.2 bits (160), Expect = 7e-11
Identities = 43/143 (30%), Positives = 72/143 (50%), Gaps = 5/143 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+ + + L + + G + +H AAQ + C++ L++ +K PVD +T +
Sbjct: 285 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ-HKAPVDDVTLD 343
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
T LH+ H + V LL+K A+ NA+ NG TPLH+A + + +++LV+
Sbjct: 344 YLTALHVAAHCGHYRVTK----LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY 399
Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
GA++ A G PI H
Sbjct: 400 GASIQAITESGLTPIHVAAFMGH 422
Score = 65.1 bits (157), Expect = 2e-10
Identities = 43/139 (30%), Positives = 70/139 (50%), Gaps = 5/139 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
A+ G+ + + L++ + G T++H AAQ K+ +L + + D T
Sbjct: 648 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK-HGADQDAHTKL 706
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPL + H N + + +LL++GA++NA+T NG TPLH AA+ G + VL+Q
Sbjct: 707 GYTPLIVACHYGNVKM----VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 762
Query: 234 GANVHAQDAMGYKPIDFCK 252
GA +A A G + K
Sbjct: 763 GAKPNATTANGNTALAIAK 781
Score = 50.1 bits (118), Expect = 5e-06
Identities = 41/134 (30%), Positives = 68/134 (50%), Gaps = 11/134 (8%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGF---TAIHFAAQWGKLACLQVLVEEYKFPVDLL 170
AA +VE ++ L + P DD TA+H AA G ++L+++ P +
Sbjct: 318 AAQGDHVECVKHLLQH---KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP-NAR 373
Query: 171 TNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
N TPLH+ ++ V + L++ GA + A T +G TP+H+AA G L+ V +L
Sbjct: 374 ALNGFTPLHIACKKNRIKV----MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 429
Query: 231 VQSGANVHAQDAMG 244
+Q+GA+ + G
Sbjct: 430 LQNGASPDVTNIRG 443
Score = 45.1 bits (105), Expect = 2e-04
Identities = 30/91 (32%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
G+T + A +G + + L+++ V+ T N TPLH + +T + I LL+
Sbjct: 707 GYTPLIVACHYGNVKMVNFLLKQGA-NVNAKTKNGYTPLHQAAQQGHTHI----INVLLQ 761
Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
GA NA T NG+T L +A R G + V L
Sbjct: 762 HGAKPNATTANGNTALAIAKRLGYISVVDTL 792
Score = 42.4 bits (98), Expect = 0.001
Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 13/166 (7%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA +++ +++ L + + GFT + A Q G + +L+E D
Sbjct: 116 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-----DTKGKV 170
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADL------NAQTCNGSTPLHLAARDGLLDCV 227
LH+ +D+T A + + AD+ N T +G TPLH+AA G ++
Sbjct: 171 RLPALHIAARKDDTKSA--ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228
Query: 228 KVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKK 273
+L+ GA V G P+ + + L D + D K
Sbjct: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 274
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 74.3 bits (181), Expect = 3e-13
Identities = 49/152 (32%), Positives = 67/152 (44%), Gaps = 5/152 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
+A G V+ L KGFT +H AA++G L ++L++ + D N
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR-RAAADSAGKN 595
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ H DN VAL LLEKGA +A NG TPLH+AA+ + L+
Sbjct: 596 GLTPLHVAAHYDNQKVAL----LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 651
Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
GA + G P+ H L D
Sbjct: 652 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683
Score = 73.9 bits (180), Expect = 3e-13
Identities = 43/128 (33%), Positives = 67/128 (52%), Gaps = 5/128 (3%)
Query: 136 TDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIY 195
T + GFT +H AA +G + +L+ VD N TPLH+ R NT + +
Sbjct: 229 TTESGFTPLHIAAHYGNVNVATLLLNRGA-AVDFTARNGITPLHVASKRGNTNM----VK 283
Query: 196 YLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWN 255
LL++G ++A+T +G TPLH AAR G V++L++ GA + A+ G P+ +
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343
Query: 256 HRACARFL 263
H C + L
Sbjct: 344 HVECVKHL 351
Score = 67.0 bits (162), Expect = 4e-11
Identities = 62/233 (26%), Positives = 107/233 (45%), Gaps = 9/233 (3%)
Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
L AA GN++ + L + + G A+H AA+ G + +Q L+ VD T
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS-SVDSAT 94
Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
T LH+ V + L+++GA++NAQ+ NG TPL++AA++ +D VK L+
Sbjct: 95 KKGNTALHIASLAGQAEV----VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 150
Query: 232 QSGANVHAQDAMGYKPIDFCKIWNH-RACARFLKDAMWKKDKKDFAREMTKMKMFKSQLT 290
++GAN G+ P+ H +A A L++ K + + KS
Sbjct: 151 ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAAL 210
Query: 291 LMEHNYLIEYQKEHKILR--EAAIRKWLHGKLHPGHSLVSNTKQARATALSKT 341
L+++++ + Q + + R E+ LH H G+ V+ R A+ T
Sbjct: 211 LLQNDHNADVQSKMMVNRTTESGFTP-LHIAAHYGNVNVATLLLNRGAAVDFT 262
Score = 66.6 bits (161), Expect = 5e-11
Identities = 42/135 (31%), Positives = 69/135 (51%), Gaps = 5/135 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA +G++ + L T+ +G TA+H AA+ G++ ++ L+ VD
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL-VDARARE 496
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
QTPLH+ T + + LL+ A +A T NG TPLH++AR+G +D VL+++
Sbjct: 497 EQTPLHIASRLGKTEI----VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 552
Query: 234 GANVHAQDAMGYKPI 248
GA G+ P+
Sbjct: 553 GAAHSLATKKGFTPL 567
Score = 66.2 bits (160), Expect = 7e-11
Identities = 43/143 (30%), Positives = 72/143 (50%), Gaps = 5/143 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+ + + L + + G + +H AAQ + C++ L++ +K PVD +T +
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ-HKAPVDDVTLD 364
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
T LH+ H + V LL+K A+ NA+ NG TPLH+A + + +++LV+
Sbjct: 365 YLTALHVAAHCGHYRVTK----LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY 420
Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
GA++ A G PI H
Sbjct: 421 GASIQAITESGLTPIHVAAFMGH 443
Score = 65.1 bits (157), Expect = 2e-10
Identities = 43/139 (30%), Positives = 70/139 (50%), Gaps = 5/139 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
A+ G+ + + L++ + G T++H AAQ K+ +L + + D T
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK-HGADQDAHTKL 727
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPL + H N + + +LL++GA++NA+T NG TPLH AA+ G + VL+Q
Sbjct: 728 GYTPLIVACHYGNVKM----VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Query: 234 GANVHAQDAMGYKPIDFCK 252
GA +A A G + K
Sbjct: 784 GAKPNATTANGNTALAIAK 802
Score = 50.1 bits (118), Expect = 5e-06
Identities = 41/134 (30%), Positives = 68/134 (50%), Gaps = 11/134 (8%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGF---TAIHFAAQWGKLACLQVLVEEYKFPVDLL 170
AA +VE ++ L + P DD TA+H AA G ++L+++ P +
Sbjct: 339 AAQGDHVECVKHLLQH---KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP-NAR 394
Query: 171 TNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
N TPLH+ ++ V + L++ GA + A T +G TP+H+AA G L+ V +L
Sbjct: 395 ALNGFTPLHIACKKNRIKV----MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Query: 231 VQSGANVHAQDAMG 244
+Q+GA+ + G
Sbjct: 451 LQNGASPDVTNIRG 464
Score = 45.1 bits (105), Expect = 2e-04
Identities = 30/91 (32%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
G+T + A +G + + L+++ V+ T N TPLH + +T + I LL+
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGA-NVNAKTKNGYTPLHQAAQQGHTHI----INVLLQ 782
Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
GA NA T NG+T L +A R G + V L
Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 42.4 bits (98), Expect = 0.001
Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 13/166 (7%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA +++ +++ L + + GFT + A Q G + +L+E D
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-----DTKGKV 191
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADL------NAQTCNGSTPLHLAARDGLLDCV 227
LH+ +D+T A + + AD+ N T +G TPLH+AA G ++
Sbjct: 192 RLPALHIAARKDDTKSA--ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 249
Query: 228 KVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKK 273
+L+ GA V G P+ + + L D + D K
Sbjct: 250 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 74.3 bits (181), Expect = 3e-13
Identities = 49/152 (32%), Positives = 67/152 (44%), Gaps = 5/152 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
+A G V+ L KGFT +H AA++G L ++L++ + D N
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR-RAAADSAGKN 595
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ H DN VAL LLEKGA +A NG TPLH+AA+ + L+
Sbjct: 596 GLTPLHVAAHYDNQKVAL----LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 651
Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
GA + G P+ H L D
Sbjct: 652 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683
Score = 73.9 bits (180), Expect = 3e-13
Identities = 43/128 (33%), Positives = 67/128 (52%), Gaps = 5/128 (3%)
Query: 136 TDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIY 195
T + GFT +H AA +G + +L+ VD N TPLH+ R NT + +
Sbjct: 229 TTESGFTPLHIAAHYGNVNVATLLLNRGA-AVDFTARNGITPLHVASKRGNTNM----VK 283
Query: 196 YLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWN 255
LL++G ++A+T +G TPLH AAR G V++L++ GA + A+ G P+ +
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343
Query: 256 HRACARFL 263
H C + L
Sbjct: 344 HVECVKHL 351
Score = 67.0 bits (162), Expect = 4e-11
Identities = 62/233 (26%), Positives = 107/233 (45%), Gaps = 9/233 (3%)
Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
L AA GN++ + L + + G A+H AA+ G + +Q L+ VD T
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS-SVDSAT 94
Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
T LH+ V + L+++GA++NAQ+ NG TPL++AA++ +D VK L+
Sbjct: 95 KKGNTALHIASLAGQAEV----VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 150
Query: 232 QSGANVHAQDAMGYKPIDFCKIWNH-RACARFLKDAMWKKDKKDFAREMTKMKMFKSQLT 290
++GAN G+ P+ H +A A L++ K + + KS
Sbjct: 151 ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAAL 210
Query: 291 LMEHNYLIEYQKEHKILR--EAAIRKWLHGKLHPGHSLVSNTKQARATALSKT 341
L+++++ + Q + + R E+ LH H G+ V+ R A+ T
Sbjct: 211 LLQNDHNADVQSKMMVNRTTESGFTP-LHIAAHYGNVNVATLLLNRGAAVDFT 262
Score = 66.6 bits (161), Expect = 5e-11
Identities = 42/135 (31%), Positives = 69/135 (51%), Gaps = 5/135 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA +G++ + L T+ +G TA+H AA+ G++ ++ L+ VD
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL-VDARARE 496
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
QTPLH+ T + + LL+ A +A T NG TPLH++AR+G +D VL+++
Sbjct: 497 EQTPLHIASRLGKTEI----VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 552
Query: 234 GANVHAQDAMGYKPI 248
GA G+ P+
Sbjct: 553 GAAHSLATKKGFTPL 567
Score = 66.2 bits (160), Expect = 7e-11
Identities = 43/143 (30%), Positives = 72/143 (50%), Gaps = 5/143 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+ + + L + + G + +H AAQ + C++ L++ +K PVD +T +
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ-HKAPVDDVTLD 364
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
T LH+ H + V LL+K A+ NA+ NG TPLH+A + + +++LV+
Sbjct: 365 YLTALHVAAHCGHYRVTK----LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY 420
Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
GA++ A G PI H
Sbjct: 421 GASIQAITESGLTPIHVAAFMGH 443
Score = 65.1 bits (157), Expect = 2e-10
Identities = 43/139 (30%), Positives = 70/139 (50%), Gaps = 5/139 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
A+ G+ + + L++ + G T++H AAQ K+ +L + + D T
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK-HGADQDAHTKL 727
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPL + H N + + +LL++GA++NA+T NG TPLH AA+ G + VL+Q
Sbjct: 728 GYTPLIVACHYGNVKM----VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Query: 234 GANVHAQDAMGYKPIDFCK 252
GA +A A G + K
Sbjct: 784 GAKPNATTANGNTALAIAK 802
Score = 50.1 bits (118), Expect = 5e-06
Identities = 41/134 (30%), Positives = 68/134 (50%), Gaps = 11/134 (8%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGF---TAIHFAAQWGKLACLQVLVEEYKFPVDLL 170
AA +VE ++ L + P DD TA+H AA G ++L+++ P +
Sbjct: 339 AAQGDHVECVKHLLQH---KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP-NAR 394
Query: 171 TNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
N TPLH+ ++ V + L++ GA + A T +G TP+H+AA G L+ V +L
Sbjct: 395 ALNGFTPLHIACKKNRIKV----MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Query: 231 VQSGANVHAQDAMG 244
+Q+GA+ + G
Sbjct: 451 LQNGASPDVTNIRG 464
Score = 45.1 bits (105), Expect = 2e-04
Identities = 30/91 (32%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
G+T + A +G + + L+++ V+ T N TPLH + +T + I LL+
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGA-NVNAKTKNGYTPLHQAAQQGHTHI----INVLLQ 782
Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
GA NA T NG+T L +A R G + V L
Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 42.4 bits (98), Expect = 0.001
Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 13/166 (7%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA +++ +++ L + + GFT + A Q G + +L+E D
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-----DTKGKV 191
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADL------NAQTCNGSTPLHLAARDGLLDCV 227
LH+ +D+T A + + AD+ N T +G TPLH+AA G ++
Sbjct: 192 RLPALHIAARKDDTKSA--ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 249
Query: 228 KVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKK 273
+L+ GA V G P+ + + L D + D K
Sbjct: 250 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 72.4 bits (176), Expect = 1e-12
Identities = 65/221 (29%), Positives = 100/221 (45%), Gaps = 26/221 (11%)
Query: 34 GSMQQANKVSLKATWTDAESKQPSQPLPDLADHLSAQATAL------ARPRRPAS--LTP 85
G ++ AN + K+ DA K PL +A H Q AL A P A TP
Sbjct: 576 GKLEVANLLLQKSASPDAAGKSGLTPL-HVAAHYDNQKVALLLLDQGASPHAAAKNGYTP 634
Query: 86 PRADPSPSKE----------SDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIP 135
++ +D A+ + I S + AA G+V+ + L ++
Sbjct: 635 LHIAAKKNQMDIATTLLEYGADANAVTRQGIASVH--LAAQEGHVDMVSLLLGRNANVNL 692
Query: 136 TDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIY 195
++ G T +H AAQ ++ +VLV + VD T TPLH+ H N + +
Sbjct: 693 SNKSGLTPLHLAAQEDRVNVAEVLVNQGAH-VDAQTKMGYTPLHVGCHYGNIKI----VN 747
Query: 196 YLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGAN 236
+LL+ A +NA+T NG TPLH AA+ G + VL+Q+ A+
Sbjct: 748 FLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788
Score = 71.2 bits (173), Expect = 2e-12
Identities = 43/142 (30%), Positives = 74/142 (52%), Gaps = 5/142 (3%)
Query: 115 AAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNS 174
A G+ + + L+++ + G + +H A Q L C+Q+L++ + PVD +TN+
Sbjct: 309 ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ-HNVPVDDVTNDY 367
Query: 175 QTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSG 234
T LH+ H + VA LL+K A+ NA+ NG TPLH+A + + +++L++ G
Sbjct: 368 LTALHVAAHCGHYKVAK----VLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHG 423
Query: 235 ANVHAQDAMGYKPIDFCKIWNH 256
A++ A G PI H
Sbjct: 424 ASIQAVTESGLTPIHVAAFMGH 445
Score = 67.4 bits (163), Expect = 3e-11
Identities = 42/135 (31%), Positives = 71/135 (52%), Gaps = 5/135 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA +G+V + ++ T+ +G TA+H AA+ G+ ++ LV++ V+ +
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGA-QVEAKAKD 498
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
QTPLH+ + + LL++GA NA T +G TPLHL+AR+G D L+
Sbjct: 499 DQTPLHISARLGKADI----VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH 554
Query: 234 GANVHAQDAMGYKPI 248
GA++ G+ P+
Sbjct: 555 GASLSITTKKGFTPL 569
Score = 67.0 bits (162), Expect = 4e-11
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 5/124 (4%)
Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
GFT +H AA +G + +L+ VD N TPLH+ R N + + LL+
Sbjct: 235 GFTPLHIAAHYGNINVATLLLNRAA-AVDFTARNDITPLHVASKRGNANM----VKLLLD 289
Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
+GA ++A+T +G TPLH AR G V++L+ A + ++ G P+ +H C
Sbjct: 290 RGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNC 349
Query: 260 ARFL 263
+ L
Sbjct: 350 VQLL 353
Score = 65.5 bits (158), Expect = 1e-10
Identities = 45/152 (29%), Positives = 73/152 (48%), Gaps = 5/152 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G E +R+ + + T +H +A+ GK +Q L+++ P + T +
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP-NAATTS 531
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLHL + VA +LL+ GA L+ T G TPLH+AA+ G L+ +L+Q
Sbjct: 532 GYTPLHLSAREGHEDVAA----FLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587
Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
A+ A G P+ ++++ A L D
Sbjct: 588 SASPDAAGKSGLTPLHVAAHYDNQKVALLLLD 619
Score = 64.3 bits (155), Expect = 3e-10
Identities = 42/135 (31%), Positives = 63/135 (46%), Gaps = 5/135 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G +E L +S G T +H AA + +L+++ P N
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP-HAAAKN 630
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH+ ++ +A LLE GAD NA T G +HLAA++G +D V +L+
Sbjct: 631 GYTPLHIAAKKNQMDIATT----LLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 686
Query: 234 GANVHAQDAMGYKPI 248
ANV+ + G P+
Sbjct: 687 NANVNLSNKSGLTPL 701
Score = 62.8 bits (151), Expect = 8e-10
Identities = 68/287 (23%), Positives = 106/287 (36%), Gaps = 79/287 (27%)
Query: 23 GRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPLPDLADHLSAQATALARPRRPAS 82
G A SG + + +A++K PL H+SA+ L +
Sbjct: 466 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPL-----HISAR---LGKADIVQQ 517
Query: 83 LTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFT 142
L A P+ + S T + +A G+ + F L+ T KGFT
Sbjct: 518 LLQQGASPNAATTSGYTPLH----------LSAREGHEDVAAFLLDHGASLSITTKKGFT 567
Query: 143 AIHFAAQWGKLACLQVLVEEYKFP---------------------VDLL----------- 170
+H AA++GKL +L+++ P V LL
Sbjct: 568 PLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAA 627
Query: 171 TNNSQTPLHLVIHRDNTTVALPCIYY-----------------------------LLEKG 201
N TPLH+ ++ +A + Y LL +
Sbjct: 628 AKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRN 687
Query: 202 ADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
A++N +G TPLHLAA++ ++ +VLV GA+V AQ MGY P+
Sbjct: 688 ANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPL 734
Score = 62.0 bits (149), Expect = 1e-09
Identities = 40/128 (31%), Positives = 60/128 (46%), Gaps = 5/128 (3%)
Query: 138 DKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYL 197
+ G T IH AA G + + L+ P + +T LH+ V + YL
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMHHGASP-NTTNVRGETALHMAARSGQAEV----VRYL 485
Query: 198 LEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHR 257
++ GA + A+ + TPLH++AR G D V+ L+Q GA+ +A GY P+ H
Sbjct: 486 VQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHE 545
Query: 258 ACARFLKD 265
A FL D
Sbjct: 546 DVAAFLLD 553
Score = 58.9 bits (141), Expect = 1e-08
Identities = 34/99 (34%), Positives = 53/99 (53%), Gaps = 4/99 (4%)
Query: 167 VDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDC 226
+++ N LHL + V + LL++ A+++A T G+T LH+A+ G +
Sbjct: 67 INICNQNGLNALHLASKEGHVEV----VSELLQREANVDAATKKGNTALHIASLAGQAEV 122
Query: 227 VKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
VKVLV +GANV+AQ G+ P+ NH +FL D
Sbjct: 123 VKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD 161
Score = 57.0 bits (136), Expect = 4e-08
Identities = 39/137 (28%), Positives = 68/137 (49%), Gaps = 5/137 (3%)
Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
L AA G++E + + + G A+H A++ G + + L++ + VD T
Sbjct: 46 LRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR-EANVDAAT 104
Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
T LH+ V + L+ GA++NAQ+ NG TPL++AA++ L+ VK L+
Sbjct: 105 KKGNTALHIASLAGQAEV----VKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLL 160
Query: 232 QSGANVHAQDAMGYKPI 248
+GA+ G+ P+
Sbjct: 161 DNGASQSLATEDGFTPL 177
Score = 52.0 bits (123), Expect = 1e-06
Identities = 38/143 (26%), Positives = 69/143 (48%), Gaps = 5/143 (3%)
Query: 95 ESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLA 154
++D A ++ G AA GN+ LN++ T T +H A++ G
Sbjct: 223 QNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNAN 282
Query: 155 CLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTP 214
+++L++ +D T + TPLH + V + LL++ A + ++T NG +P
Sbjct: 283 MVKLLLDR-GAKIDAKTRDGLTPLHCGARSGHEQV----VEMLLDRAAPILSKTKNGLSP 337
Query: 215 LHLAARDGLLDCVKVLVQSGANV 237
LH+A + L+CV++L+Q V
Sbjct: 338 LHMATQGDHLNCVQLLLQHNVPV 360
Score = 51.2 bits (121), Expect = 2e-06
Identities = 46/180 (25%), Positives = 73/180 (40%), Gaps = 32/180 (17%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVE------------ 161
AA ++E ++F L+ + + GFT + A Q G + +L+E
Sbjct: 147 AAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPAL 206
Query: 162 -------EYKFPVDLLTNNSQ---------TPLHLVIHRDNTTVALPCIYYLLEKGADLN 205
+ K LL N++ TPLH+ H N VA LL + A ++
Sbjct: 207 HIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVAT----LLLNRAAAVD 262
Query: 206 AQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
N TPLH+A++ G + VK+L+ GA + A+ G P+ H L D
Sbjct: 263 FTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLD 322
Score = 33.5 bits (75), Expect = 0.49
Identities = 17/57 (29%), Positives = 28/57 (49%)
Query: 118 GNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNS 174
GN++ + F L S + G+T +H AAQ G + VL++ P +L N +
Sbjct: 741 GNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGN 797
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 68.9 bits (167), Expect = 1e-11
Identities = 52/146 (35%), Positives = 72/146 (49%), Gaps = 7/146 (4%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDD-KGFTAIHFAAQWGKLACLQVLV--EEYKFPVDLL 170
AA G+VE + +NQ + D T IH AA G CL++L+ E + VD+
Sbjct: 590 AAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQ 649
Query: 171 TNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
N QTPL L + +T C+Y LL KGA+++A+ G T LH A G +CV L
Sbjct: 650 DGNGQTPLMLSVLNGHTD----CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705
Query: 231 VQSGANVHAQDAMGYKPIDFCKIWNH 256
+Q GA +D+ G PI H
Sbjct: 706 LQHGAKCLLRDSRGRTPIHLSAACGH 731
Score = 67.8 bits (164), Expect = 2e-11
Identities = 49/141 (34%), Positives = 71/141 (50%), Gaps = 7/141 (4%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA +VE L+ L+ + + D G T + AA+ G+ +++LV + L N+
Sbjct: 830 AAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNS 889
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGAD---LNAQTCNGSTPLHLAARDGLLDCVKVL 230
T LHL + + T AL +LEK D +NA TPLH+AAR+GL V+ L
Sbjct: 890 KNTALHLACSKGHETSAL----LILEKITDRNLINATNAALQTPLHVAARNGLTMVVQEL 945
Query: 231 VQSGANVHAQDAMGYKPIDFC 251
+ GA+V A D GY P C
Sbjct: 946 LGKGASVLAVDENGYTPALAC 966
Score = 65.9 bits (159), Expect = 9e-11
Identities = 61/223 (27%), Positives = 94/223 (42%), Gaps = 18/223 (8%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+ E ++ L++ D K AIH+AA G + +++LV + V
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS-HGAEVTCKDKK 205
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
S TPLH +V + YLL+ G D+N G+TPLH+A +G V L+
Sbjct: 206 SYTPLHAAASSGMISV----VKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDC 261
Query: 234 GANVHAQDAMGYKPIDFCKIWNHRA-CARFLKD-----AMWKKDKKDFAREMTKMKMFKS 287
GA V+ ++ G+ P+ F H A C L M KD K F
Sbjct: 262 GAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSR 321
Query: 288 QLTLMEHNYLIEYQKEHKILREAAIRKWLHGKLHPGHSLVSNT 330
T+++ +I+ + ++ LH GH L+ NT
Sbjct: 322 SQTIIQSGAVIDCEDKNG-------NTPLHIAARYGHELLINT 357
Score = 60.5 bits (145), Expect = 4e-09
Identities = 38/113 (33%), Positives = 61/113 (53%), Gaps = 6/113 (5%)
Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
D+ G+TA+H+A G C+++L+E+ F N+ +PLH + DN A I
Sbjct: 753 DNHGYTALHWACYNGHETCVELLLEQEVF--QKTEGNAFSPLHCAVINDNEGAAEMLIDT 810
Query: 197 LLEKGADL-NAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
L GA + NA G TPLH AA ++C+++L+ A V++ D+ G P+
Sbjct: 811 L---GASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPL 860
Score = 60.1 bits (144), Expect = 5e-09
Identities = 45/153 (29%), Positives = 68/153 (44%), Gaps = 10/153 (6%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G + R L+ DD G T +H AA G L CL +L+ +
Sbjct: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGA-DFNKKDKF 437
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAAR---DGLLDCVKVL 230
++PLH N C++ L+ GA +N G TPLH AA DG C++ L
Sbjct: 438 GRSPLHYAAANCN----YQCLFALVGSGASVNDLDERGCTPLHYAATSDTDG--KCLEYL 491
Query: 231 VQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
+++ AN +D GY + + + HR C + +
Sbjct: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLI 524
Score = 58.5 bits (140), Expect = 1e-08
Identities = 41/139 (29%), Positives = 70/139 (50%), Gaps = 6/139 (4%)
Query: 137 DDKGFTAIHFAAQWGKLA-CLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIY 195
++KGFT +HFAA A CL++LV V++ + + +TPLH+ + +
Sbjct: 269 NEKGFTPLHFAAASTHGALCLELLVGNGA-DVNMKSKDGKTPLHMTALHGRFSRSQT--- 324
Query: 196 YLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWN 255
+++ GA ++ + NG+TPLH+AAR G + L+ SGA+ + G P+ +
Sbjct: 325 -IIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSG 383
Query: 256 HRACARFLKDAMWKKDKKD 274
C R L + + D D
Sbjct: 384 FSDCCRKLLSSGFDIDTPD 402
Score = 54.3 bits (129), Expect = 3e-07
Identities = 37/135 (27%), Positives = 58/135 (42%), Gaps = 5/135 (3%)
Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
G T +H A G+ + Q +++ +D N TPLH+ + + I L+
Sbjct: 306 GKTPLHMTALHGRFSRSQTIIQSGAV-IDCEDKNGNTPLHIAARYGHELL----INTLIT 360
Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
GAD + +G PLHLAA G DC + L+ SG ++ D G + + C
Sbjct: 361 SGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLEC 420
Query: 260 ARFLKDAMWKKDKKD 274
L + +KKD
Sbjct: 421 LNLLLNTGADFNKKD 435
Score = 53.9 bits (128), Expect = 4e-07
Identities = 46/165 (27%), Positives = 72/165 (43%), Gaps = 8/165 (4%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA +G+ E + + R D K T +H A +QVL++ + V+ N
Sbjct: 48 AAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLK-HSADVNARDKN 106
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
QTPLH+ A+ C L+ +++N G T LH AA G + VK+L+
Sbjct: 107 WQTPLHIAA----ANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 162
Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFLKD---AMWKKDKKDF 275
GAN++A D + I + H + L + KDKK +
Sbjct: 163 GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSY 207
Score = 52.4 bits (124), Expect = 1e-06
Identities = 37/111 (33%), Positives = 52/111 (46%), Gaps = 5/111 (4%)
Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
G +H AA G C + L+ F +D + +T LH N L C+ LL
Sbjct: 372 GMFPLHLAALSGFSDCCRKLLSS-GFDIDTPDDFGRTCLHAAAAGGN----LECLNLLLN 426
Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDF 250
GAD N + G +PLH AA + C+ LV SGA+V+ D G P+ +
Sbjct: 427 TGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHY 477
Score = 51.6 bits (122), Expect = 2e-06
Identities = 45/159 (28%), Positives = 70/159 (44%), Gaps = 18/159 (11%)
Query: 127 LNQSLREIPT-DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN---SQTPLHLVI 182
L QSL ++ + G T + AA G + C+ VL+ + +L + +TP+H
Sbjct: 569 LVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQ---GASILVKDYILKRTPIHAAA 625
Query: 183 HRDNTTVALPCIYYLLEKGADLNA---QTCNGSTPLHLAARDGLLDCVKVLVQSGANVHA 239
++ C+ L+ NA Q NG TPL L+ +G DCV L+ GANV A
Sbjct: 626 TNGHSE----CLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDA 681
Query: 240 QDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFARE 278
+D G + + H C DA+ + K R+
Sbjct: 682 KDKWGRTALHRGAVTGHEECV----DALLQHGAKCLLRD 716
Score = 51.2 bits (121), Expect = 2e-06
Identities = 36/129 (27%), Positives = 58/129 (44%), Gaps = 30/129 (23%)
Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
D +G+ A+H++A +G CLQ++ E P+D+L S
Sbjct: 502 DKQGYNAVHYSAAYGHRLCLQLIASET--PLDVLMETS---------------------- 537
Query: 197 LLEKGADLNAQTCNGST--PLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIW 254
G D+ + + N +T PLHLAA G ++VLVQS ++ +++ G P+D
Sbjct: 538 ----GTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFK 593
Query: 255 NHRACARFL 263
H C L
Sbjct: 594 GHVECVDVL 602
Score = 49.3 bits (116), Expect = 9e-06
Identities = 38/143 (26%), Positives = 65/143 (45%), Gaps = 11/143 (7%)
Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
D++ T +H AA G +++L+ V+ + TPLH + + + +
Sbjct: 38 DNEKRTPLHAAAYLGDAEIIELLILSGA-RVNAKDSKWLTPLHRAV----ASCSEEAVQV 92
Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
LL+ AD+NA+ N TPLH+AA + + C + LV +NV+ D G + H
Sbjct: 93 LLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGH 152
Query: 257 RACARFLK------DAMWKKDKK 273
+ L +A KKD++
Sbjct: 153 GEMVKLLLSRGANINAFDKKDRR 175
Score = 39.7 bits (91), Expect = 0.007
Identities = 25/71 (35%), Positives = 39/71 (54%), Gaps = 7/71 (9%)
Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
L+ K D+N Q TPLH AA G + +++L+ SGA V+A+D+ P+ H
Sbjct: 27 LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPL-------H 79
Query: 257 RACARFLKDAM 267
RA A ++A+
Sbjct: 80 RAVASCSEEAV 90
>gi|13129098 ankyrin repeat and SOCS box-containing 8 [Homo sapiens]
Length = 288
Score = 68.9 bits (167), Expect = 1e-11
Identities = 46/135 (34%), Positives = 67/135 (49%), Gaps = 6/135 (4%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
A V + + + L + D TA+H+AA+ + AC++VL+E Y + L N
Sbjct: 60 ACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE-ACVEVLLE-YGANPNALDGN 117
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
TPLH ++N C+ LLE GA +NA N TPL AA G L+ V +L+
Sbjct: 118 RDTPLHWAAFKNNAE----CVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDY 173
Query: 234 GANVHAQDAMGYKPI 248
GA V + +G PI
Sbjct: 174 GAEVRVINLIGQTPI 188
Score = 57.8 bits (138), Expect = 2e-08
Identities = 38/122 (31%), Positives = 60/122 (49%), Gaps = 6/122 (4%)
Query: 144 IHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGAD 203
+H A C+++L+E+ V+ L ++T LH +D C+ LLE GA+
Sbjct: 57 LHCACMVSDADCVELLLEKGA-EVNALDGYNRTALHYAAEKDEA-----CVEVLLEYGAN 110
Query: 204 LNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
NA N TPLH AA +CV+ L++SGA+V+A D P+ + + + L
Sbjct: 111 PNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSIL 170
Query: 264 KD 265
D
Sbjct: 171 LD 172
Score = 49.7 bits (117), Expect = 7e-06
Identities = 38/137 (27%), Positives = 64/137 (46%), Gaps = 6/137 (4%)
Query: 171 TNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
T+ + PLH + C+ LLEKGA++NA T LH AA CV+VL
Sbjct: 50 THGTLKPLHCACMVSDAD----CVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVL 104
Query: 231 VQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLT 290
++ GAN +A D P+ + N+ C R L ++ + D+ + T + +
Sbjct: 105 LEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNND-TPLSWAAMKGN 163
Query: 291 LMEHNYLIEYQKEHKIL 307
L + L++Y E +++
Sbjct: 164 LESVSILLDYGAEVRVI 180
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 68.6 bits (166), Expect = 1e-11
Identities = 47/135 (34%), Positives = 70/135 (51%), Gaps = 12/135 (8%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLV-----EEYKFPVD 168
AA GNV+ LR L + D++G+ IH AA + CLQ+L+ E Y +
Sbjct: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY---IK 73
Query: 169 LLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVK 228
+ T LHL + + + + LLE GAD NA T +TPL LA +G +D ++
Sbjct: 74 MKTFEGFCALHLAASQGHWKI----VQILLEAGADPNATTLEETTPLFLAVENGQIDVLR 129
Query: 229 VLVQSGANVHAQDAM 243
+L+Q GANV+ +M
Sbjct: 130 LLLQHGANVNGSHSM 144
Score = 52.8 bits (125), Expect = 8e-07
Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 34/183 (18%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDK---GFTAIHFAAQWGKLACLQVLVEEYKFPVDLL 170
AA +VE L+ +N E K GF A+H AA G +Q+L+E P +
Sbjct: 50 AAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADP-NAT 108
Query: 171 TNNSQTPLHLVI------------------------------HRDNTTVALPCIYYLLEK 200
T TPL L + H+ + I LL K
Sbjct: 109 TLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK 168
Query: 201 GADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACA 260
GA+ Q G TPL +AA+ G L+ + +L+ SGANV+ Q P+ H C
Sbjct: 169 GANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCV 228
Query: 261 RFL 263
L
Sbjct: 229 ELL 231
Score = 48.9 bits (115), Expect = 1e-05
Identities = 40/155 (25%), Positives = 63/155 (40%), Gaps = 52/155 (33%)
Query: 119 NVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPL 178
N E ++ L + + DD G T + AAQ+GKL L +L+
Sbjct: 158 NAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISS---------------- 201
Query: 179 HLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGAN-- 236
GA++N Q + +TPL +AA++G CV++L+ SGA+
Sbjct: 202 ----------------------GANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD 239
Query: 237 -----------VHAQDAMGY-KPIDFCKIWNHRAC 259
+HA MG+ K +D +RAC
Sbjct: 240 LYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC 274
Score = 33.1 bits (74), Expect = 0.65
Identities = 24/81 (29%), Positives = 38/81 (46%), Gaps = 10/81 (12%)
Query: 206 AQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
A TC+ + LAAR+G + ++ L++ G +V D G+ PI N C + L +
Sbjct: 8 ADTCS---TVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLIN 64
Query: 266 AMWKKDKKDFAREMTKMKMFK 286
A D + KMK F+
Sbjct: 65 A-------DSSENYIKMKTFE 78
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 67.8 bits (164), Expect = 2e-11
Identities = 47/138 (34%), Positives = 65/138 (47%), Gaps = 1/138 (0%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA NV LR L TD G TA+ AA+ G+ A ++ L+ K + +L N
Sbjct: 865 AAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDEN 924
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
T LHL + + AL + + G +NA PLH+AAR+GL V+ L+
Sbjct: 925 KNTALHLACSKGHEKCALMILAETQDLGL-INATNSALQMPLHIAARNGLASVVQALLSH 983
Query: 234 GANVHAQDAMGYKPIDFC 251
GA V A D G+ P C
Sbjct: 984 GATVLAVDEEGHTPALAC 1001
Score = 63.5 bits (153), Expect = 4e-10
Identities = 61/236 (25%), Positives = 95/236 (40%), Gaps = 26/236 (11%)
Query: 23 GRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPLPDLA--DHLSAQATALARPRRP 80
GR A SG ++ N + K + K+ QPL A HL +AR
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARG--- 196
Query: 81 ASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKG 140
+D D+ G + AAA G +E +++ L + G
Sbjct: 197 ---------------ADLGCKDRKGYGLLHT--AAASGQIEVVKYLLRMGAEIDEPNAFG 239
Query: 141 FTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEK 200
TA+H A G+ A LV V+ + TPLH+ N + C+ L+
Sbjct: 240 NTALHIACYLGQDAVAIELVNAGA-NVNQPNDKGFTPLHVAAVSTNGAL---CLELLVNN 295
Query: 201 GADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
GAD+N Q+ G +PLH+AA G ++L+Q+G+ + D G P+ + H
Sbjct: 296 GADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGH 351
Score = 60.5 bits (145), Expect = 4e-09
Identities = 44/136 (32%), Positives = 60/136 (44%), Gaps = 6/136 (4%)
Query: 141 FTAIHFAAQWGKLACLQVLVE--EYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLL 198
+T +H AA G L +L++ E D++ QTPL L I + + C++ LL
Sbjct: 653 WTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGH----VDCVHLLL 708
Query: 199 EKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRA 258
EKG+ +A G T LH A G DC+ L+ A V +D G PI H A
Sbjct: 709 EKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTA 768
Query: 259 CARFLKDAMWKKDKKD 274
R L A D D
Sbjct: 769 VLRTLLQAALSTDPLD 784
Score = 56.2 bits (134), Expect = 7e-08
Identities = 46/138 (33%), Positives = 70/138 (50%), Gaps = 14/138 (10%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDD----KGFTAIHFAAQWGKLACLQVLVEEYKFPVDL 169
A+A G+ LR L +L P D G++ +H+A+ G CL++L+E P
Sbjct: 761 ASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHS--PFSY 818
Query: 170 LTNNSQTPLHLVI--HRDNTTVALPCIYYLLEKGADL-NAQTCNGSTPLHLAARDGLLDC 226
L N TPLH + ++D+TT L L GA + N++ G TPLH AA +
Sbjct: 819 LEGNPFTPLHCAVINNQDSTTEML-----LGALGAKIVNSRDAKGRTPLHAAAFADNVSG 873
Query: 227 VKVLVQSGANVHAQDAMG 244
+++L+Q A V+A D G
Sbjct: 874 LRMLLQHQAEVNATDHTG 891
Score = 52.0 bits (123), Expect = 1e-06
Identities = 30/86 (34%), Positives = 41/86 (47%), Gaps = 4/86 (4%)
Query: 165 FPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLL 224
F ++ N +T LH N + C+ LL GADL + G TPLH AA +G
Sbjct: 414 FDINTPDNLGRTCLHAAASGGN----VECLNLLLSSGADLRRRDKFGRTPLHYAAANGSY 469
Query: 225 DCVKVLVQSGANVHAQDAMGYKPIDF 250
C LV +GA V+ D G P+ +
Sbjct: 470 QCAVTLVTAGAGVNEADCKGCSPLHY 495
Score = 49.7 bits (117), Expect = 7e-06
Identities = 37/129 (28%), Positives = 63/129 (48%), Gaps = 8/129 (6%)
Query: 137 DDKGFTAIHFAA-QWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLV-IHRDNTTVALPCI 194
+DKGFT +H AA CL++LV V+ + ++PLH+ IH T +
Sbjct: 269 NDKGFTPLHVAAVSTNGALCLELLVNNGA-DVNYQSKEGKSPLHMAAIHGRFTRSQI--- 324
Query: 195 YYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIW 254
L++ G++++ G+TPLH+AAR G + L+ +GA+ + P+ ++
Sbjct: 325 --LIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLF 382
Query: 255 NHRACARFL 263
C R L
Sbjct: 383 GFSDCCRKL 391
Score = 49.3 bits (116), Expect = 9e-06
Identities = 34/115 (29%), Positives = 56/115 (48%), Gaps = 5/115 (4%)
Query: 123 LRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVE-EYKFPVDLLTNNSQTPLHLV 181
L F L+ D +G+TA+H+AA +G L++L+E + D+ + +PLHL
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592
Query: 182 IHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGAN 236
+ + + L E +L+ + G T L LA G +CV+VL GA+
Sbjct: 593 AYNGH----CEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGAS 643
Score = 47.4 bits (111), Expect = 3e-05
Identities = 42/157 (26%), Positives = 66/157 (42%), Gaps = 12/157 (7%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDK---GFTAIHFAAQWGKLACLQVLVEEYKFPVDLL 170
AAA G+ + L ++ R TD G T + A G + C+ +L+E+ D
Sbjct: 659 AAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS-TADAA 717
Query: 171 TNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
+T LH R T C+ LL+ A + + G TP+HLA+ G ++ L
Sbjct: 718 DLRGRTALH----RGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTL 773
Query: 231 VQSGANVHAQDA----MGYKPIDFCKIWNHRACARFL 263
+Q+ + DA GY P+ + H C L
Sbjct: 774 LQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL 810
Score = 45.4 bits (106), Expect = 1e-04
Identities = 43/158 (27%), Positives = 69/158 (43%), Gaps = 34/158 (21%)
Query: 127 LNQSLREIPTDDK-GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQT--------- 176
L Q+ EI DK G T +H AA++G ++L+ L+TN + T
Sbjct: 325 LIQNGSEIDCADKFGNTPLHVAARYGH----ELLIST------LMTNGADTARRGIHDMF 374
Query: 177 PLHLVI--------------HRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDG 222
PLHL + + + V+ ++L G D+N G T LH AA G
Sbjct: 375 PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434
Query: 223 LLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACA 260
++C+ +L+ SGA++ +D G P+ + CA
Sbjct: 435 NVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCA 472
Score = 41.2 bits (95), Expect = 0.002
Identities = 39/150 (26%), Positives = 60/150 (40%), Gaps = 5/150 (3%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA VG+V L+ L D T +H AA L +L+ + V+
Sbjct: 48 AAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLA-HSADVNARDKL 106
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
QTPLH+ A C L + LN +G + LH A G L+ V +L+
Sbjct: 107 WQTPLHVAA----ANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNK 162
Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFL 263
GA+++ D +P+ + H + L
Sbjct: 163 GASLNVCDKKERQPLHWAAFLGHLEVLKLL 192
Score = 40.4 bits (93), Expect = 0.004
Identities = 27/97 (27%), Positives = 46/97 (47%), Gaps = 4/97 (4%)
Query: 167 VDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDC 226
+++L +TPLH + + +P + LL GA++NA+ TPLH AA
Sbjct: 34 INVLDQERRTPLHAAAYVGD----VPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKV 89
Query: 227 VKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
+ +L+ A+V+A+D + P+ CA L
Sbjct: 90 LGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126
Score = 40.4 bits (93), Expect = 0.004
Identities = 44/187 (23%), Positives = 68/187 (36%), Gaps = 27/187 (14%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA+ GNVE L L+ D G T +H+AA G C LV V+
Sbjct: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTA-GAGVNEADCK 488
Query: 174 SQTPLHLVIHRDNTTVALP------------------------CIYYLLEKGADLNAQTC 209
+PLH D A P C+ +LL+ GAD + +
Sbjct: 489 GCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDR 548
Query: 210 NGSTPLHLAARDGLLDCVKVLVQSGANV--HAQDAMGYKPIDFCKIWNHRACARFLKDAM 267
G T +H AA G +++L++ N + + P+ H + L + +
Sbjct: 549 QGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETL 608
Query: 268 WKKDKKD 274
D +D
Sbjct: 609 VNLDVRD 615
Score = 39.3 bits (90), Expect = 0.009
Identities = 33/128 (25%), Positives = 55/128 (42%), Gaps = 1/128 (0%)
Query: 105 AIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYK 164
A G + A G+V+ + L + D +G TA+H A G CL L++
Sbjct: 686 AYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDA 745
Query: 165 FPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLL 224
F V +TP+HL +T V + L +G +P+H A+ G
Sbjct: 746 F-VLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHE 804
Query: 225 DCVKVLVQ 232
DC+++L++
Sbjct: 805 DCLELLLE 812
Score = 38.1 bits (87), Expect = 0.020
Identities = 23/64 (35%), Positives = 35/64 (54%), Gaps = 7/64 (10%)
Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
LL + ++N TPLH AA G + +++L+ SGANV+A+D + P+ H
Sbjct: 27 LLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPL-------H 79
Query: 257 RACA 260
RA A
Sbjct: 80 RAAA 83
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 66.6 bits (161), Expect = 5e-11
Identities = 56/176 (31%), Positives = 85/176 (48%), Gaps = 9/176 (5%)
Query: 100 AIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLR-EIPTDDKGFTAIHFAAQWGKLACLQV 158
A+DQ+ G + AAA G + L E+PT +G+T +H AA G L + +
Sbjct: 555 ALDQSGYGPLHT--AAARGKYLICKMLLRYGASLELPTH-QGWTPLHLAAYKGHLEIIHL 611
Query: 159 LVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLA 218
L E + + L + TPLHL V + LL+ GAD NA +G TPLHLA
Sbjct: 612 LAESHA-NMGALGAVNWTPLHLAARHGEEAV----VSALLQCGADPNAAEQSGWTPLHLA 666
Query: 219 ARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKD 274
+ V L++ ANVHA++ +G+ P + + A + L +A + D +D
Sbjct: 667 VQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722
Score = 58.9 bits (141), Expect = 1e-08
Identities = 47/149 (31%), Positives = 72/149 (48%), Gaps = 12/149 (8%)
Query: 113 FAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTN 172
FAA G+ R L+ + +G+T +H AAQ ++LV P +L
Sbjct: 434 FAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADP-NLHEA 492
Query: 173 NSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQ 232
+TPLH+ + + ++ + L +GA+L+AQ N TPLHLA G + ++ L++
Sbjct: 493 EGKTPLHVAAYFGHVSL----VKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548
Query: 233 SGANVHAQDAMGYKPIDFCKIWNHRACAR 261
SGA A D GY P+ H A AR
Sbjct: 549 SGAVPDALDQSGYGPL-------HTAAAR 570
Score = 54.7 bits (130), Expect = 2e-07
Identities = 36/108 (33%), Positives = 57/108 (52%), Gaps = 5/108 (4%)
Query: 141 FTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEK 200
+T +H AA+ G+ A + L++ P + + TPLHL + R + LLE
Sbjct: 627 WTPLHLAARHGEEAVVSALLQCGADP-NAAEQSGWTPLHLAVQRSTFL----SVINLLEH 681
Query: 201 GADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
A+++A+ G TP HLAA G +KVLV++GA + QD + P+
Sbjct: 682 HANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729
Score = 53.1 bits (126), Expect = 6e-07
Identities = 36/128 (28%), Positives = 61/128 (47%), Gaps = 5/128 (3%)
Query: 139 KGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLL 198
+G T +H AA +G ++ +++L + +D N +TPLHL + R I +LL
Sbjct: 493 EGKTPLHVAAYFGHVSLVKLLTSQGA-ELDAQQRNLRTPLHLAVERGKVRA----IQHLL 547
Query: 199 EKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRA 258
+ GA +A +G PLH AA G K+L++ GA++ G+ P+ H
Sbjct: 548 KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLE 607
Query: 259 CARFLKDA 266
L ++
Sbjct: 608 IIHLLAES 615
Score = 50.1 bits (118), Expect = 5e-06
Identities = 42/152 (27%), Positives = 69/152 (45%), Gaps = 7/152 (4%)
Query: 113 FAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTN 172
F A G+VE +R L + G+T + AAQ + L L+ + + +
Sbjct: 368 FLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQ-DQQPDLCALLLAHGADANRVDE 426
Query: 173 NSQTPLHLVIHR-DNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
+ PLH D+ T L LL+ GA ++AQ G TPLHLAA++ + ++LV
Sbjct: 427 DGWAPLHFAAQNGDDGTARL-----LLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481
Query: 232 QSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
A+ + +A G P+ + H + + L
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513
Score = 45.8 bits (107), Expect = 1e-04
Identities = 29/93 (31%), Positives = 45/93 (48%), Gaps = 4/93 (4%)
Query: 173 NSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQ 232
N TPLH ++ + + + LL D++ QT +G TPL +AA+D D +L+
Sbjct: 361 NKVTPLHFLVAQGSVEQ----VRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA 416
Query: 233 SGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
GA+ + D G+ P+ F AR L D
Sbjct: 417 HGADANRVDEDGWAPLHFAAQNGDDGTARLLLD 449
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 65.5 bits (158), Expect = 1e-10
Identities = 78/305 (25%), Positives = 128/305 (41%), Gaps = 41/305 (13%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+V ++ L + + TD T + A + G +Q L++ VDL+ +
Sbjct: 364 AALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA-RVDLVDQD 422
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
+ LH N V L+E + N Q G TPL AA G ++C+ VL+++
Sbjct: 423 GHSLLHWAALGGNADVC----QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEN 478
Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLT--- 290
A+ + QD G + H +C DA+ K DFA +M+ + + T
Sbjct: 479 NADPNIQDKEGRTAL-------HWSCNNGYLDAI--KLLLDFAAFPNQMENNEERYTPLD 529
Query: 291 ---LMEHNYLIEYQKEHKILREAAIRKWLHGKLHPGH-------------SLVSNTKQAR 334
L E + +I++ EH L AAI+ K+ + +L+ +Q R
Sbjct: 530 YALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLR 589
Query: 335 ATALSKTPEQR------ESQRSRSFHPSVDAR-LQCIPQPTEMPKPIYRKPTVKRPTMWN 387
A +K E+ E Q+ R S + L C+P ++P R P+ K+P N
Sbjct: 590 KDAAAKKREEENKRKEAEQQKGRRSPDSCRPQALPCLPSTQDVPSRQSRAPS-KQPPAGN 648
Query: 388 VSNNP 392
V+ P
Sbjct: 649 VAQGP 653
Score = 49.7 bits (117), Expect = 7e-06
Identities = 49/178 (27%), Positives = 79/178 (44%), Gaps = 21/178 (11%)
Query: 99 TAIDQTAIGSYYQLF------AAAVGNVEWLRFCLNQSLR-EIPTDDKGFTAIHFAAQWG 151
T+ + I SY LF AA +G+ + + L ++ IP+D +G T +H+AAQ
Sbjct: 241 TSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSN 300
Query: 152 KLACLQVLVEE--YKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTC 209
++V ++ K DL +T + + V + L+ D+N
Sbjct: 301 FAETVKVFLKHPSVKDDSDL---EGRTSFMWAAGKGSDDVLRTMLS--LKSDIDINMADK 355
Query: 210 NGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAM 267
G T LH AA G + VK+L+++ A V A D M + P+ RAC KD +
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPL-------FRACEMGHKDVI 406
Score = 43.9 bits (102), Expect = 4e-04
Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 5/135 (3%)
Query: 133 EIPTDDKGF-TAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVI-HRDNTTV- 189
E+ T DK TA+H++A + +++L++ + + + + PLH H+D + V
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIK-HDSNIGIPDVEGKIPLHWAANHKDPSAVH 199
Query: 190 ALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQ-SGANVHAQDAMGYKPI 248
+ CI + LN Q G TPLH A DG + V VL N+ + D + P+
Sbjct: 200 TVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPL 259
Query: 249 DFCKIWNHRACARFL 263
+ + H L
Sbjct: 260 HWAALLGHAQIVHLL 274
Score = 39.3 bits (90), Expect = 0.009
Identities = 33/105 (31%), Positives = 46/105 (43%), Gaps = 4/105 (3%)
Query: 144 IHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGAD 203
+H AA G LQ L+ D +TPL + D L C LL+ GAD
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR----LDCADALLKAGAD 73
Query: 204 LNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
+N + T LHLAA+ G +K+L+ AN +D P+
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPL 118
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 65.5 bits (158), Expect = 1e-10
Identities = 78/305 (25%), Positives = 128/305 (41%), Gaps = 41/305 (13%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
AA G+V ++ L + + TD T + A + G +Q L++ VDL+ +
Sbjct: 364 AALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA-RVDLVDQD 422
Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
+ LH N V L+E + N Q G TPL AA G ++C+ VL+++
Sbjct: 423 GHSLLHWAALGGNADVC----QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEN 478
Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLT--- 290
A+ + QD G + H +C DA+ K DFA +M+ + + T
Sbjct: 479 NADPNIQDKEGRTAL-------HWSCNNGYLDAI--KLLLDFAAFPNQMENNEERYTPLD 529
Query: 291 ---LMEHNYLIEYQKEHKILREAAIRKWLHGKLHPGH-------------SLVSNTKQAR 334
L E + +I++ EH L AAI+ K+ + +L+ +Q R
Sbjct: 530 YALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLR 589
Query: 335 ATALSKTPEQR------ESQRSRSFHPSVDAR-LQCIPQPTEMPKPIYRKPTVKRPTMWN 387
A +K E+ E Q+ R S + L C+P ++P R P+ K+P N
Sbjct: 590 KDAAAKKREEENKRKEAEQQKGRRSPDSCRPQALPCLPSTQDVPSRQSRAPS-KQPPAGN 648
Query: 388 VSNNP 392
V+ P
Sbjct: 649 VAQGP 653
Score = 49.7 bits (117), Expect = 7e-06
Identities = 49/178 (27%), Positives = 79/178 (44%), Gaps = 21/178 (11%)
Query: 99 TAIDQTAIGSYYQLF------AAAVGNVEWLRFCLNQSLR-EIPTDDKGFTAIHFAAQWG 151
T+ + I SY LF AA +G+ + + L ++ IP+D +G T +H+AAQ
Sbjct: 241 TSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSN 300
Query: 152 KLACLQVLVEE--YKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTC 209
++V ++ K DL +T + + V + L+ D+N
Sbjct: 301 FAETVKVFLKHPSVKDDSDL---EGRTSFMWAAGKGSDDVLRTMLS--LKSDIDINMADK 355
Query: 210 NGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAM 267
G T LH AA G + VK+L+++ A V A D M + P+ RAC KD +
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPL-------FRACEMGHKDVI 406
Score = 43.9 bits (102), Expect = 4e-04
Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 5/135 (3%)
Query: 133 EIPTDDKGF-TAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVI-HRDNTTV- 189
E+ T DK TA+H++A + +++L++ + + + + PLH H+D + V
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIK-HDSNIGIPDVEGKIPLHWAANHKDPSAVH 199
Query: 190 ALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQ-SGANVHAQDAMGYKPI 248
+ CI + LN Q G TPLH A DG + V VL N+ + D + P+
Sbjct: 200 TVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPL 259
Query: 249 DFCKIWNHRACARFL 263
+ + H L
Sbjct: 260 HWAALLGHAQIVHLL 274
Score = 39.3 bits (90), Expect = 0.009
Identities = 33/105 (31%), Positives = 46/105 (43%), Gaps = 4/105 (3%)
Query: 144 IHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGAD 203
+H AA G LQ L+ D +TPL + D L C LL+ GAD
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR----LDCADALLKAGAD 73
Query: 204 LNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
+N + T LHLAA+ G +K+L+ AN +D P+
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPL 118
>gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo
sapiens]
Length = 313
Score = 65.1 bits (157), Expect = 2e-10
Identities = 47/162 (29%), Positives = 81/162 (50%), Gaps = 7/162 (4%)
Query: 108 SYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPV 167
S +QL AA G + +L + Q TD++GFT + +AA G++A ++ L++ P
Sbjct: 152 SVHQL--AAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADP- 208
Query: 168 DLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCV 227
LL ++ L L + T + + LL+ G D+N NG TPL A + CV
Sbjct: 209 QLLGKGRESALSLACSKGYTDI----VKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCV 264
Query: 228 KVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWK 269
K+L++SGA+ + GY +D +R+ + ++ + K
Sbjct: 265 KMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLK 306
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 64.7 bits (156), Expect = 2e-10
Identities = 59/233 (25%), Positives = 99/233 (42%), Gaps = 48/233 (20%)
Query: 118 GNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTP 177
GN+E L L + +D G A+H AA++G CLQ L++ Y P + +T
Sbjct: 66 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQ-YNCPTEHADLQGRTA 124
Query: 178 LHLVIHRD----------------------------NTTVALPCIYYLL-EKGADLNAQT 208
LH D T ++ P I LL ++GAD+N++
Sbjct: 125 LHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRD 184
Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDA-- 266
T L L G D V+VL+++GA++ DA+G+ + +I ++ LK A
Sbjct: 185 KQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASE 244
Query: 267 -------MWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEYQKEHKILREAAI 312
+WKK R +T M + ++ + H Q+EH+ +++ I
Sbjct: 245 NTNKGRELWKKGPSLQQRNLTHM---QDEVNVKSH------QREHQNIQDLEI 288
Score = 32.7 bits (73), Expect = 0.84
Identities = 20/66 (30%), Positives = 29/66 (43%), Gaps = 4/66 (6%)
Query: 179 HLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVH 238
H+V + N L C+ +L G D+ G LHLAA+ G C++ L+Q
Sbjct: 60 HVVTSKGN----LECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTE 115
Query: 239 AQDAMG 244
D G
Sbjct: 116 HADLQG 121
Score = 30.8 bits (68), Expect = 3.2
Identities = 14/67 (20%), Positives = 27/67 (40%)
Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
L +KG + G + H+ G L+C+ ++ G ++ D G + + H
Sbjct: 41 LAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGH 100
Query: 257 RACARFL 263
C + L
Sbjct: 101 ALCLQKL 107
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 64.7 bits (156), Expect = 2e-10
Identities = 59/233 (25%), Positives = 99/233 (42%), Gaps = 48/233 (20%)
Query: 118 GNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTP 177
GN+E L L + +D G A+H AA++G CLQ L++ Y P + +T
Sbjct: 79 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQ-YNCPTEHADLQGRTA 137
Query: 178 LHLVIHRD----------------------------NTTVALPCIYYLL-EKGADLNAQT 208
LH D T ++ P I LL ++GAD+N++
Sbjct: 138 LHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRD 197
Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDA-- 266
T L L G D V+VL+++GA++ DA+G+ + +I ++ LK A
Sbjct: 198 KQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASE 257
Query: 267 -------MWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEYQKEHKILREAAI 312
+WKK R +T M + ++ + H Q+EH+ +++ I
Sbjct: 258 NTNKGRELWKKGPSLQQRNLTHM---QDEVNVKSH------QREHQNIQDLEI 301
Score = 32.7 bits (73), Expect = 0.84
Identities = 20/66 (30%), Positives = 29/66 (43%), Gaps = 4/66 (6%)
Query: 179 HLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVH 238
H+V + N L C+ +L G D+ G LHLAA+ G C++ L+Q
Sbjct: 73 HVVTSKGN----LECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTE 128
Query: 239 AQDAMG 244
D G
Sbjct: 129 HADLQG 134
Score = 30.8 bits (68), Expect = 3.2
Identities = 14/67 (20%), Positives = 27/67 (40%)
Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
L +KG + G + H+ G L+C+ ++ G ++ D G + + H
Sbjct: 54 LAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGH 113
Query: 257 RACARFL 263
C + L
Sbjct: 114 ALCLQKL 120
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 64.3 bits (155), Expect = 3e-10
Identities = 36/94 (38%), Positives = 49/94 (52%), Gaps = 4/94 (4%)
Query: 170 LTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKV 229
LT N T LHL +++DN + I LL GAD+ G T LH+A G L+ V
Sbjct: 97 LTRNGFTALHLAVYKDNAEL----ITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADV 152
Query: 230 LVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
L+Q GANV+ QDA+ + P+ + H R L
Sbjct: 153 LLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL 186
Score = 62.4 bits (150), Expect = 1e-09
Identities = 42/126 (33%), Positives = 65/126 (51%), Gaps = 7/126 (5%)
Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
G TA+H A G L VL++ + V++ TPLH+ + + V LL+
Sbjct: 134 GLTALHIATIAGHLEAADVLLQ-HGANVNIQDAVFFTPLHIAAYYGHEQVTR----LLLK 188
Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSG--ANVHAQDAMGYKPIDFCKIWNHR 257
GAD+N G PLHLA+ G L+ K+L++ G A+V+AQD + P+ FC + H
Sbjct: 189 FGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHH 248
Query: 258 ACARFL 263
++L
Sbjct: 249 DIVKYL 254
Score = 47.4 bits (111), Expect = 3e-05
Identities = 50/166 (30%), Positives = 69/166 (41%), Gaps = 21/166 (12%)
Query: 101 IDQTAIGSYYQLFAAAV-GNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVL 159
I Q G L A + G++E L D FT +H AA +G ++L
Sbjct: 127 IQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL 186
Query: 160 VEEYKFPVDLLTNNS--QTPLHLVIHRDNTTVALPCIYYLLEKG--ADLNAQTCNGSTPL 215
+ KF D+ + PLHL + +A L+E+G AD+NAQ PL
Sbjct: 187 L---KFGADVNVSGEVGDRPLHLASAKGFLNIAK----LLMEEGSKADVNAQDNEDHVPL 239
Query: 216 HLAARDGLLDCVKVLVQSGANV--HAQDAMGYKPIDFCKIWNHRAC 259
H +R G D VK L+QS V H + G P+ H AC
Sbjct: 240 HFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL-------HLAC 278
Score = 44.3 bits (103), Expect = 3e-04
Identities = 40/156 (25%), Positives = 65/156 (41%), Gaps = 9/156 (5%)
Query: 118 GNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTP 177
G +R + + LR GFTA+H A + L+ + + T
Sbjct: 79 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGA-DIQQVGYGGLTA 137
Query: 178 LHLVIHRDNTTVA--LPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGA 235
LH+ T+A L LL+ GA++N Q TPLH+AA G ++L++ GA
Sbjct: 138 LHIA------TIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA 191
Query: 236 NVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKD 271
+V+ +G +P+ A+ L + K D
Sbjct: 192 DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD 227
Score = 40.4 bits (93), Expect = 0.004
Identities = 33/122 (27%), Positives = 53/122 (43%), Gaps = 7/122 (5%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEE-YKFPVDLLTN 172
AA G+ + R L + + G +H A+ G L ++L+EE K V+ N
Sbjct: 174 AAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDN 233
Query: 173 NSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCN--GSTPLHLAARDGLLDCVKVL 230
PLH + + + YLL+ ++ N G TPLHLA +G + K +
Sbjct: 234 EDHVPLHFCSRFGHHDI----VKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEI 289
Query: 231 VQ 232
+Q
Sbjct: 290 IQ 291
Score = 30.0 bits (66), Expect = 5.5
Identities = 18/72 (25%), Positives = 36/72 (50%), Gaps = 5/72 (6%)
Query: 142 TAIHFAAQWGK-LACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEK 200
TA H A +GK + ++ L+++ ++ + T LH + + + + +LL+
Sbjct: 307 TAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL----VQFLLDN 362
Query: 201 GADLNAQTCNGS 212
GAD+N C+ S
Sbjct: 363 GADMNLVACDPS 374
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 64.3 bits (155), Expect = 3e-10
Identities = 36/94 (38%), Positives = 49/94 (52%), Gaps = 4/94 (4%)
Query: 170 LTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKV 229
LT N T LHL +++DN + I LL GAD+ G T LH+A G L+ V
Sbjct: 198 LTRNGFTALHLAVYKDNAEL----ITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADV 253
Query: 230 LVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
L+Q GANV+ QDA+ + P+ + H R L
Sbjct: 254 LLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL 287
Score = 62.4 bits (150), Expect = 1e-09
Identities = 42/126 (33%), Positives = 65/126 (51%), Gaps = 7/126 (5%)
Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
G TA+H A G L VL++ + V++ TPLH+ + + V LL+
Sbjct: 235 GLTALHIATIAGHLEAADVLLQ-HGANVNIQDAVFFTPLHIAAYYGHEQVTR----LLLK 289
Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSG--ANVHAQDAMGYKPIDFCKIWNHR 257
GAD+N G PLHLA+ G L+ K+L++ G A+V+AQD + P+ FC + H
Sbjct: 290 FGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHH 349
Query: 258 ACARFL 263
++L
Sbjct: 350 DIVKYL 355
Score = 47.4 bits (111), Expect = 3e-05
Identities = 50/166 (30%), Positives = 69/166 (41%), Gaps = 21/166 (12%)
Query: 101 IDQTAIGSYYQLFAAAV-GNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVL 159
I Q G L A + G++E L D FT +H AA +G ++L
Sbjct: 228 IQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL 287
Query: 160 VEEYKFPVDLLTNNS--QTPLHLVIHRDNTTVALPCIYYLLEKG--ADLNAQTCNGSTPL 215
+ KF D+ + PLHL + +A L+E+G AD+NAQ PL
Sbjct: 288 L---KFGADVNVSGEVGDRPLHLASAKGFLNIAK----LLMEEGSKADVNAQDNEDHVPL 340
Query: 216 HLAARDGLLDCVKVLVQSGANV--HAQDAMGYKPIDFCKIWNHRAC 259
H +R G D VK L+QS V H + G P+ H AC
Sbjct: 341 HFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL-------HLAC 379
Score = 44.3 bits (103), Expect = 3e-04
Identities = 40/156 (25%), Positives = 65/156 (41%), Gaps = 9/156 (5%)
Query: 118 GNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTP 177
G +R + + LR GFTA+H A + L+ + + T
Sbjct: 180 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGA-DIQQVGYGGLTA 238
Query: 178 LHLVIHRDNTTVA--LPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGA 235
LH+ T+A L LL+ GA++N Q TPLH+AA G ++L++ GA
Sbjct: 239 LHIA------TIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA 292
Query: 236 NVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKD 271
+V+ +G +P+ A+ L + K D
Sbjct: 293 DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD 328
Score = 40.4 bits (93), Expect = 0.004
Identities = 33/122 (27%), Positives = 53/122 (43%), Gaps = 7/122 (5%)
Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEE-YKFPVDLLTN 172
AA G+ + R L + + G +H A+ G L ++L+EE K V+ N
Sbjct: 275 AAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDN 334
Query: 173 NSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCN--GSTPLHLAARDGLLDCVKVL 230
PLH + + + YLL+ ++ N G TPLHLA +G + K +
Sbjct: 335 EDHVPLHFCSRFGHHDI----VKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEI 390
Query: 231 VQ 232
+Q
Sbjct: 391 IQ 392
Score = 30.0 bits (66), Expect = 5.5
Identities = 18/72 (25%), Positives = 36/72 (50%), Gaps = 5/72 (6%)
Query: 142 TAIHFAAQWGK-LACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEK 200
TA H A +GK + ++ L+++ ++ + T LH + + + + +LL+
Sbjct: 408 TAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL----VQFLLDN 463
Query: 201 GADLNAQTCNGS 212
GAD+N C+ S
Sbjct: 464 GADMNLVACDPS 475
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,567,057
Number of Sequences: 37866
Number of extensions: 1235769
Number of successful extensions: 7270
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 325
Number of HSP's successfully gapped in prelim test: 111
Number of HSP's that attempted gapping in prelim test: 4878
Number of HSP's gapped (non-prelim): 1714
length of query: 530
length of database: 18,247,518
effective HSP length: 107
effective length of query: 423
effective length of database: 14,195,856
effective search space: 6004847088
effective search space used: 6004847088
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.