Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 169218225
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169218225 PREDICTED: similar to U5 snRNP-specific 200kD
protein, partial [Homo sapiens]
(1700 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169218225 PREDICTED: similar to U5 snRNP-specific 200kD prote... 3400 0.0
gi|40217847 activating signal cointegrator 1 complex subunit 3-l... 3351 0.0
gi|76880486 activating signal cointegrator 1 complex subunit 3 i... 1504 0.0
gi|239756904 PREDICTED: similar to SNRNP200 protein [Homo sapiens] 471 e-132
gi|239745928 PREDICTED: hypothetical protein XP_002343618 [Homo ... 410 e-114
gi|130484567 HFM1 protein [Homo sapiens] 321 3e-87
gi|139394648 DNA polymerase theta [Homo sapiens] 136 2e-31
gi|110556640 DNA helicase HEL308 [Homo sapiens] 129 3e-29
gi|67782311 superkiller viralicidic activity 2-like homolog [Hom... 107 8e-23
gi|193211480 superkiller viralicidic activity 2-like 2 [Homo sap... 92 6e-18
gi|6005872 SEC63-like protein [Homo sapiens] 67 2e-10
gi|222831595 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 [Homo sap... 65 6e-10
gi|149274648 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Hom... 54 1e-06
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi... 46 3e-04
gi|148612816 RecQ protein-like 5 isoform 1 [Homo sapiens] 45 6e-04
gi|51242943 RecQ protein-like 5 isoform 3 [Homo sapiens] 45 6e-04
gi|51242947 RecQ protein-like 5 isoform 2 [Homo sapiens] 45 6e-04
gi|27886568 interferon induced with helicase C domain 1 [Homo sa... 43 0.002
gi|29294649 dicer1 [Homo sapiens] 42 0.005
gi|29294651 dicer1 [Homo sapiens] 42 0.005
gi|38569503 ATP-dependent RNA helicase ROK1 isoform b [Homo sapi... 42 0.007
gi|38569505 ATP-dependent RNA helicase ROK1 isoform a [Homo sapi... 42 0.007
gi|41327779 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 [Homo sapi... 40 0.015
gi|149408122 RNA helicase LGP2 [Homo sapiens] 40 0.019
gi|27881482 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I [... 39 0.043
gi|209862869 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 3 ... 39 0.043
gi|13518015 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 1 [... 39 0.043
gi|216548263 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 2 ... 39 0.043
gi|4557365 Bloom syndrome protein [Homo sapiens] 38 0.073
gi|110735439 Werner syndrome protein [Homo sapiens] 38 0.096
>gi|169218225 PREDICTED: similar to U5 snRNP-specific 200kD protein,
partial [Homo sapiens]
Length = 1700
Score = 3400 bits (8815), Expect = 0.0
Identities = 1700/1700 (100%), Positives = 1700/1700 (100%)
Query: 1 RQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETD 60
RQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETD
Sbjct: 1 RQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETD 60
Query: 61 ENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFG 120
ENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFG
Sbjct: 61 ENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFG 120
Query: 121 KRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDE 180
KRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDE
Sbjct: 121 KRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDE 180
Query: 181 IHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYF 240
IHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYF
Sbjct: 181 IHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYF 240
Query: 241 DNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTAR 300
DNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTAR
Sbjct: 241 DNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTAR 300
Query: 301 AIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTL 360
AIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTL
Sbjct: 301 AIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTL 360
Query: 361 VEDLFGDKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRA 420
VEDLFGDKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRA
Sbjct: 361 VEDLFGDKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRA 420
Query: 421 GRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDA 480
GRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDA
Sbjct: 421 GRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDA 480
Query: 481 VNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKT 540
VNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKT
Sbjct: 481 VNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKT 540
Query: 541 GNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLE 600
GNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLE
Sbjct: 541 GNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLE 600
Query: 601 LQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIF 660
LQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIF
Sbjct: 601 LQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIF 660
Query: 661 EIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDL 720
EIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDL
Sbjct: 661 EIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDL 720
Query: 721 NHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHG 780
NHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHG
Sbjct: 721 NHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHG 780
Query: 781 SSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPLPPQYFIRVVSDRWL 840
SSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPLPPQYFIRVVSDRWL
Sbjct: 781 SSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPLPPQYFIRVVSDRWL 840
Query: 841 SCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVF 900
SCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVF
Sbjct: 841 SCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVF 900
Query: 901 NTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITPMRLWQEQVYMDWYEK 960
NTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITPMRLWQEQVYMDWYEK
Sbjct: 901 NTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITPMRLWQEQVYMDWYEK 960
Query: 961 FQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEV 1020
FQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEV
Sbjct: 961 FQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEV 1020
Query: 1021 HLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLGCSATSTFNFHP 1080
HLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLGCSATSTFNFHP
Sbjct: 1021 HLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLGCSATSTFNFHP 1080
Query: 1081 NVRPVPLELHIQGFNISHTQTRLLSMAKPVFHAITKHSPKKPVIVFVPSRKQTRLTAIDI 1140
NVRPVPLELHIQGFNISHTQTRLLSMAKPVFHAITKHSPKKPVIVFVPSRKQTRLTAIDI
Sbjct: 1081 NVRPVPLELHIQGFNISHTQTRLLSMAKPVFHAITKHSPKKPVIVFVPSRKQTRLTAIDI 1140
Query: 1141 LTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYLHEGLSPMERRLVEQLF 1200
LTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYLHEGLSPMERRLVEQLF
Sbjct: 1141 LTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYLHEGLSPMERRLVEQLF 1200
Query: 1201 SSGAIQVVVASRSLCWGMNVAAHLVIIMDTLYYNGKIHAYVDYPIYDVLQMVGHANRPLQ 1260
SSGAIQVVVASRSLCWGMNVAAHLVIIMDTLYYNGKIHAYVDYPIYDVLQMVGHANRPLQ
Sbjct: 1201 SSGAIQVVVASRSLCWGMNVAAHLVIIMDTLYYNGKIHAYVDYPIYDVLQMVGHANRPLQ 1260
Query: 1261 DDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYLT 1320
DDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYLT
Sbjct: 1261 DDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYLT 1320
Query: 1321 WTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLG 1380
WTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLG
Sbjct: 1321 WTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLG 1380
Query: 1381 MIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVP 1440
MIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVP
Sbjct: 1381 MIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVP 1440
Query: 1441 HKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWL 1500
HKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWL
Sbjct: 1441 HKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWL 1500
Query: 1501 SPALAAMELAQMVTQAMWSEDSYLRRLPPFPSGLFKRCTDKGVESVFDIMEMEDEERNAL 1560
SPALAAMELAQMVTQAMWSEDSYLRRLPPFPSGLFKRCTDKGVESVFDIMEMEDEERNAL
Sbjct: 1501 SPALAAMELAQMVTQAMWSEDSYLRRLPPFPSGLFKRCTDKGVESVFDIMEMEDEERNAL 1560
Query: 1561 LQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLF 1620
LQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLF
Sbjct: 1561 LQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLF 1620
Query: 1621 PQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGGRHNTLYFMSDAYMGC 1680
PQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGGRHNTLYFMSDAYMGC
Sbjct: 1621 PQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGGRHNTLYFMSDAYMGC 1680
Query: 1681 DQEYKFSVDVKEAETDSDSD 1700
DQEYKFSVDVKEAETDSDSD
Sbjct: 1681 DQEYKFSVDVKEAETDSDSD 1700
>gi|40217847 activating signal cointegrator 1 complex subunit 3-like 1
[Homo sapiens]
Length = 2136
Score = 3351 bits (8690), Expect = 0.0
Identities = 1679/1700 (98%), Positives = 1686/1700 (99%)
Query: 1 RQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETD 60
RQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETD
Sbjct: 437 RQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETD 496
Query: 61 ENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFG 120
ENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFG
Sbjct: 497 ENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFG 556
Query: 121 KRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDE 180
KRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLI+LDE
Sbjct: 557 KRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIILDE 616
Query: 181 IHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYF 240
IHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYF
Sbjct: 617 IHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYF 676
Query: 241 DNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTAR 300
DNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTAR
Sbjct: 677 DNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTAR 736
Query: 301 AIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTL 360
AIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTL
Sbjct: 737 AIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTL 796
Query: 361 VEDLFGDKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRA 420
VEDLF DKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRA
Sbjct: 797 VEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRA 856
Query: 421 GRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDA 480
GRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDA
Sbjct: 857 GRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDA 916
Query: 481 VNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKT 540
VNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKT
Sbjct: 917 VNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKT 976
Query: 541 GNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLE 600
GNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLE
Sbjct: 977 GNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLE 1036
Query: 601 LQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIF 660
LQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIF
Sbjct: 1037 LQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIF 1096
Query: 661 EIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDL 720
EIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDL
Sbjct: 1097 EIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDL 1156
Query: 721 NHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHG 780
NHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHG
Sbjct: 1157 NHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHG 1216
Query: 781 SSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPLPPQYFIRVVSDRWL 840
SSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPLPPQYFIRVVSDRWL
Sbjct: 1217 SSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPLPPQYFIRVVSDRWL 1276
Query: 841 SCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVF 900
SCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVF
Sbjct: 1277 SCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVF 1336
Query: 901 NTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITPMRLWQEQVYMDWYEK 960
NTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQ+SEGRCVYITPM EQVYMDWYEK
Sbjct: 1337 NTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVYITPMEALAEQVYMDWYEK 1396
Query: 961 FQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEV 1020
FQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEV
Sbjct: 1397 FQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEV 1456
Query: 1021 HLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLGCSATSTFNFHP 1080
HLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLGCSATSTFNFHP
Sbjct: 1457 HLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLGCSATSTFNFHP 1516
Query: 1081 NVRPVPLELHIQGFNISHTQTRLLSMAKPVFHAITKHSPKKPVIVFVPSRKQTRLTAIDI 1140
NVRPVPLELHIQGFNISHTQTRLLSMAKPV+HAITKHSPKKPVIVFVPSRKQTRLTAIDI
Sbjct: 1517 NVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITKHSPKKPVIVFVPSRKQTRLTAIDI 1576
Query: 1141 LTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYLHEGLSPMERRLVEQLF 1200
LTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYLHEGLSPMERRLVEQLF
Sbjct: 1577 LTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYLHEGLSPMERRLVEQLF 1636
Query: 1201 SSGAIQVVVASRSLCWGMNVAAHLVIIMDTLYYNGKIHAYVDYPIYDVLQMVGHANRPLQ 1260
SSGAIQVVVASRSLCWGMNVAAHLVIIMDT YYNGKIHAYVDYPIYDVLQMVGHANRPLQ
Sbjct: 1637 SSGAIQVVVASRSLCWGMNVAAHLVIIMDTQYYNGKIHAYVDYPIYDVLQMVGHANRPLQ 1696
Query: 1261 DDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYLT 1320
DDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYLT
Sbjct: 1697 DDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYLT 1756
Query: 1321 WTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLG 1380
WTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLG
Sbjct: 1757 WTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLG 1816
Query: 1381 MIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVP 1440
MIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVP
Sbjct: 1817 MIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVP 1876
Query: 1441 HKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWL 1500
HKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWL
Sbjct: 1877 HKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWL 1936
Query: 1501 SPALAAMELAQMVTQAMWSEDSYLRRLPPFPSGLFKRCTDKGVESVFDIMEMEDEERNAL 1560
SPALAAMELAQMVTQAMWS+DSYL++LP F S KRCTDKGVESVFDIMEMEDEERNAL
Sbjct: 1937 SPALAAMELAQMVTQAMWSKDSYLKQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNAL 1996
Query: 1561 LQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLF 1620
LQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLF
Sbjct: 1997 LQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLF 2056
Query: 1621 PQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGGRHNTLYFMSDAYMGC 1680
PQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATG + TLYFMSDAYMGC
Sbjct: 2057 PQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGAHNYTLYFMSDAYMGC 2116
Query: 1681 DQEYKFSVDVKEAETDSDSD 1700
DQEYKFSVDVKEAETDSDSD
Sbjct: 2117 DQEYKFSVDVKEAETDSDSD 2136
>gi|76880486 activating signal cointegrator 1 complex subunit 3
isoform a [Homo sapiens]
Length = 2202
Score = 1504 bits (3895), Expect = 0.0
Identities = 777/1750 (44%), Positives = 1129/1750 (64%), Gaps = 63/1750 (3%)
Query: 4 KGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENL 63
K YEEV +P +P P EE+ + ++ L + Q F+G K LNRIQS ++ A T+EN+
Sbjct: 436 KLYEEVRIPYSEPMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFETAYNTNENM 495
Query: 64 LLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRL 123
L+CAPTGAGKTN+A++ +L EI +H G I ++FKI+Y+APM++L EM F +RL
Sbjct: 496 LICAPTGAGKTNIAMLTVLHEIRQHFQQ-GVIKKNEFKIVYVAPMKALAAEMTDYFSRRL 554
Query: 124 ATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKG-GERTYTQLVRLIVLDEIH 182
GI V ELTGD QL K EI TQ++V TPEKWD++TRK G+ +Q+VRL++LDE+H
Sbjct: 555 EPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILDEVH 614
Query: 183 LLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDN 242
LLH+DRGPVLE++VAR +R +E TQ +R++GLSATLPNY DVATFL V+P GLF+FD
Sbjct: 615 LLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFFFDG 674
Query: 243 SFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHA-GKNQVLVFVHSRKETGKTARA 301
FRPVPL QT++GI +++ M+E+ YE +++ +QV+VFVH+R T +TA +
Sbjct: 675 RFRPVPLGQTFLGIKCANKMQQLNNMDEVCYENVLKQVKAGHQVMVFVHARNATVRTAMS 734
Query: 302 IRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLV 361
+ + + F + + ++ +N ++++L P GF+IHHAGM R DR LV
Sbjct: 735 LIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDRNLV 794
Query: 362 EDLFGDKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAG 421
E+LF + HI+VLV TATLAWGVNLPAH VIIKGTQ+Y+ ++G + +LG LD++Q+ GRAG
Sbjct: 795 ENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAG 854
Query: 422 RPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDAV 481
RPQ+D GEGI+IT+H +L +YL+LL Q+ PIESQ + L D LNAEI LG V N ++AV
Sbjct: 855 RPQFDKFGEGIIITTHDKLSHYLTLLTQRNPIESQFLESLADNLNAEIALGTVTNVEEAV 914
Query: 482 NWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTG 541
W+ Y YLY+RM +P YGISH + DP L + R LV LDK +++++++TG
Sbjct: 915 KWISYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLVIEVGRKLDKAQMIRFEERTG 974
Query: 542 NFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLEL 601
F T+LGR ASHYYI +T++T+N+L +E ++F + S + EF I VREEE EL
Sbjct: 975 YFSSTDLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEEL 1034
Query: 602 QKLLERV-PIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIF 660
LL + +E KIN+LLQ +IS+ +++ F+L++D YV Q+A R++RA+F
Sbjct: 1035 DTLLSNFCELSTPGGVENSYGKINILLQTYISRGEMDSFSLISDSAYVAQNAARIVRALF 1094
Query: 661 EIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDL 720
EI L + W +T + LNL K+IDKR+W PLRQF LP ++ ++E+K ++L D+
Sbjct: 1095 EIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPPHILTRLEEKKLTVDKLKDM 1154
Query: 721 NHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHG 780
+EIG ++ +G + + VH P + + +QPITR+ L+V L+I DF W+++VHG
Sbjct: 1155 RKDEIGHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTLSIYADFTWNDQVHG 1214
Query: 781 S-SEAFWILVEDVDSEVILHHEYFLLKAKY--AQDEHLITFFVPVFEPLPPQYFIRVVSD 837
+ E +WI VED ++ I H EYFL K +++ L+ F +P+FEPLP QY+IR VSD
Sbjct: 1215 TVGEPWWIWVEDPTNDHIYHSEYFLALKKQVISKEAQLLVFTIPIFEPLPSQYYIRAVSD 1274
Query: 838 RWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQT 897
RWL E ++F+HLILPE++PP TELLDLQPLP++AL A+E+LY F FNP+QT
Sbjct: 1275 RWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEALYN--FSHFNPVQT 1332
Query: 898 QVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITPMRLWQEQVYMDW 957
Q+F+T+Y++D NV +GAPTGSGKT+ AE AI R+ + + VYI P++ + DW
Sbjct: 1333 QIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDW 1392
Query: 958 YEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVV 1017
+ +++L KKV+ LTG+ + D+K + K ++I++TPEKWD +SR W+ R VQ + + ++
Sbjct: 1393 KVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRNYVQQVTILII 1452
Query: 1018 DEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLGCSATSTFN 1077
DE+HL+G E GPVLEVI SR +ISS E+P+RIV LS++L+NA+D+A WL FN
Sbjct: 1453 DEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMGLFN 1512
Query: 1078 FHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVFHAITKHSPKKPVIVFVPSRKQTRLTA 1137
F P+VRPVPLE+HIQGF H R+ SM KP F AI HSP KPV++FV SR+QTRLTA
Sbjct: 1513 FRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTA 1572
Query: 1138 IDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYLHEGLSPMERRLVE 1197
++++ A + +++L+ E+++ + + DS LK TL G+G H GL +R+ VE
Sbjct: 1573 LELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVE 1632
Query: 1198 QLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTLYYNGKIHAYVDYPIYDVLQMVGHANR 1257
+LF + +QV++A+ +L WG+N AHLVII T YY+GK YVD+PI DVLQM+G A R
Sbjct: 1633 ELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGR 1692
Query: 1258 PLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVD 1317
P DD+G+ VI+ KKDF+KKFLYEP PVES L + DH NAEI TI +KQDA+D
Sbjct: 1693 PQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALD 1752
Query: 1318 YLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISI-EDEMDVAP 1376
Y+TWT+ +RR+ NP+YYNL +SH ++ LS L+E++L +LE S CI I ED + P
Sbjct: 1753 YITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSHLIEKSLIELELSYCIEIGEDNRSIEP 1812
Query: 1377 LNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLA 1436
L G IA+YYY+ + T+++F L + L+ I+S+A EY ++P+RH+ED++ +LA
Sbjct: 1813 LTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLPVRHNEDHMNSELA 1872
Query: 1437 QKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLSA-ELQSDTEEILSKAIRLIQACVDVLS 1495
+ +P + N F+ PH K +LLLQAHLSR L + +DT+ +L +A+R+ QA +DV +
Sbjct: 1873 KCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAA 1932
Query: 1496 SNGWLSPALAAMELAQMVTQAMWSEDSYLRRLPPFPS---GLFKRCTD--KG-------- 1542
+ GWL L L QMV Q W +DS L LP + LFK+ KG
Sbjct: 1933 NQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFKKWKPIMKGPHARGRTS 1992
Query: 1543 VESVFDIMEMEDEERNALLQLTDSQI-----ADVARFCNRYPNI---------------- 1581
+ES+ +++ + + + +S++ F + P I
Sbjct: 1993 IESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGISVKGSWDDLVEG 2052
Query: 1582 --ELSYEVVDKD--------SIRSGGPVVVLVQLER------EEEVTGPVIAPLFPQKRE 1625
ELS + D + + V+ V L+R + + + P FP+ ++
Sbjct: 2053 HNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKD 2112
Query: 1626 EGWWVVIGDAKSNSLISIKRL-TLQQKAKVKLDFVAPATGGRH-NTLYFMSDAYMGCDQE 1683
EGW++++G+ LI++KR+ ++ L F P GR+ TLYFMSD Y+G DQ+
Sbjct: 2113 EGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYIYTLYFMSDCYLGLDQQ 2172
Query: 1684 YKFSVDVKEA 1693
Y ++V +A
Sbjct: 2173 YDIYLNVTQA 2182
>gi|239756904 PREDICTED: similar to SNRNP200 protein [Homo sapiens]
Length = 302
Score = 471 bits (1212), Expect = e-132
Identities = 245/311 (78%), Positives = 262/311 (84%), Gaps = 18/311 (5%)
Query: 1390 YTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVPHKLNNPKFN 1449
+ ++ F S+ T+V E A YENIPI+HHE+N LRQLAQKVP KLNNPKFN
Sbjct: 10 FLKLKTFGFSIQEGTRVG---ERKRGATGYENIPIQHHEENFLRQLAQKVPDKLNNPKFN 66
Query: 1450 DPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMEL 1509
DPH+KTNLLLQAHLSRMQLSAELQSDTEEILSKA+RL+QACVDVLSSNGWLS ALAAMEL
Sbjct: 67 DPHIKTNLLLQAHLSRMQLSAELQSDTEEILSKAVRLVQACVDVLSSNGWLSSALAAMEL 126
Query: 1510 AQMVTQAMWSEDSYLRRLPPFPSGLFKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIA 1569
AQMVTQAMWS+DSYL++LP F S KRCTDKGV+SVFDIMEMEDEERN +LQLTDSQI
Sbjct: 127 AQMVTQAMWSKDSYLKQLPHFISEHIKRCTDKGVKSVFDIMEMEDEERNTILQLTDSQIT 186
Query: 1570 DVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWW 1629
D EVVDKDSIRSGGP VVLVQLEREEEVTGPVIAPLFPQKREEGWW
Sbjct: 187 D---------------EVVDKDSIRSGGPAVVLVQLEREEEVTGPVIAPLFPQKREEGWW 231
Query: 1630 VVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGGRHNTLYFMSDAYMGCDQEYKFSVD 1689
VVIGD KSNSLISIKRL LQQKAKVKLDFVAPATG + TLYFMSDAYMGCDQEYKFS+D
Sbjct: 232 VVIGDTKSNSLISIKRLILQQKAKVKLDFVAPATGAHNYTLYFMSDAYMGCDQEYKFSMD 291
Query: 1690 VKEAETDSDSD 1700
VKEAETDSDSD
Sbjct: 292 VKEAETDSDSD 302
Score = 61.6 bits (148), Expect = 6e-09
Identities = 61/269 (22%), Positives = 113/269 (42%), Gaps = 22/269 (8%)
Query: 588 FKNITVREEEKLELQKLLERVPIPVKE-SIEEPSAKINVLLQAFISQLKLEGFALMADMV 646
++NI ++ E+ L++L ++VP + +P K N+LLQA +S+++L L +D
Sbjct: 36 YENIPIQHHEENFLRQLAQKVPDKLNNPKFNDPHIKTNLLLQAHLSRMQLSA-ELQSDTE 94
Query: 647 YVTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKK 706
+ A RL++A +++ + GW + L +M+ + MW L+Q E +K+
Sbjct: 95 EILSKAVRLVQACVDVLSSNGWLSSALAAMELAQMVTQAMWSKDSYLKQLPHFISEHIKR 154
Query: 707 IEKKN----FPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTL 762
K F + D N I +L + + K +V L + R
Sbjct: 155 CTDKGVKSVFDIMEMEDEERNTILQLTDSQITDEVVDK--DSIRSGGPAVVLVQLEREEE 212
Query: 763 KVELTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLL--KAKYAQDEHLITFFV 820
I P F + E +W+++ D S ++ + +L KAK D F
Sbjct: 213 VTGPVIAPLFPQKRE-----EGWWVVIGDTKSNSLISIKRLILQQKAKVKLD-----FVA 262
Query: 821 PVFEPLPPQYFIRVVSDRWLSCETQLPVS 849
P Y + +SD ++ C+ + S
Sbjct: 263 PATG--AHNYTLYFMSDAYMGCDQEYKFS 289
>gi|239745928 PREDICTED: hypothetical protein XP_002343618 [Homo
sapiens]
Length = 299
Score = 410 bits (1053), Expect = e-114
Identities = 217/298 (72%), Positives = 230/298 (77%), Gaps = 52/298 (17%)
Query: 1403 KTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAH 1462
+TKVRGLIEIISNAA YENIPI+HHE+N LRQLAQKVP KLNNPKFNDPH+KTNLLLQAH
Sbjct: 54 RTKVRGLIEIISNAAGYENIPIQHHEENFLRQLAQKVPDKLNNPKFNDPHIKTNLLLQAH 113
Query: 1463 LSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSEDS 1522
LSRMQLSAELQSDTEEILSKA+RL+QACVDVLSSNGWLS ALAAMELAQMVTQAMWS+DS
Sbjct: 114 LSRMQLSAELQSDTEEILSKAVRLVQACVDVLSSNGWLSSALAAMELAQMVTQAMWSKDS 173
Query: 1523 YLRRLPPFPSGLFKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPNIE 1582
YL++LP F S KRCTDKGV+SVFDIMEMEDEERN +LQLTDSQI D
Sbjct: 174 YLKQLPHFISEHIKRCTDKGVKSVFDIMEMEDEERNTILQLTDSQITD------------ 221
Query: 1583 LSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSNSLIS 1642
KREEGWWVVIGD KSNSLIS
Sbjct: 222 ----------------------------------------KREEGWWVVIGDTKSNSLIS 241
Query: 1643 IKRLTLQQKAKVKLDFVAPATGGRHNTLYFMSDAYMGCDQEYKFSVDVKEAETDSDSD 1700
IKRL LQQKAKVKLDFVAPATG + TLYFMSDAYMGCDQEYKFS+DVKEAETDSDSD
Sbjct: 242 IKRLILQQKAKVKLDFVAPATGAHNYTLYFMSDAYMGCDQEYKFSMDVKEAETDSDSD 299
Score = 62.0 bits (149), Expect = 5e-09
Identities = 40/156 (25%), Positives = 76/156 (48%), Gaps = 6/156 (3%)
Query: 578 LFRVFSLSSEFKNITVREEEKLELQKLLERVPIPVKE-SIEEPSAKINVLLQAFISQLKL 636
L + S ++ ++NI ++ E+ L++L ++VP + +P K N+LLQA +S+++L
Sbjct: 60 LIEIISNAAGYENIPIQHHEENFLRQLAQKVPDKLNNPKFNDPHIKTNLLLQAHLSRMQL 119
Query: 637 EGFALMADMVYVTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQF 696
L +D + A RL++A +++ + GW + L +M+ + MW L+Q
Sbjct: 120 SA-ELQSDTEEILSKAVRLVQACVDVLSSNGWLSSALAAMELAQMVTQAMWSKDSYLKQL 178
Query: 697 RKLPEEVVKKIEKKN----FPFERLYDLNHNEIGEL 728
E +K+ K F + D N I +L
Sbjct: 179 PHFISEHIKRCTDKGVKSVFDIMEMEDEERNTILQL 214
>gi|130484567 HFM1 protein [Homo sapiens]
Length = 1435
Score = 321 bits (823), Expect = 3e-87
Identities = 258/818 (31%), Positives = 425/818 (51%), Gaps = 59/818 (7%)
Query: 25 LLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLRE 84
L V ++P ++ F+ F N IQSK + L TD N ++CAPTG+GKT V + + R
Sbjct: 261 LKAVTEIPAKFRSIFKEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRL 320
Query: 85 IGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKE-E 143
+ M+ + + KI+Y+AP+++L + + ++ G+ ELTGD + E
Sbjct: 321 L-----MEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGPIGLNCKELTGDTVMDDLFE 375
Query: 144 ISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDEIHLLHDD-RGPVLEALVAR--AI 200
I II+ TPEKWD +TRK + + QLVRL ++DE+H++ D+ RGP LE +V+R +
Sbjct: 376 IQHAHIIMTTPEKWDSMTRKWRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTV 435
Query: 201 RNIEMTQED------VRLIGLSATLPNYEDVATFLRVDPAKGL-FYFDNSFRPVPLEQTY 253
+++ T ++ +R + +SAT+PN ED+A +L + D S RPV L++
Sbjct: 436 QSVSQTLKNTSTAIPMRFVAVSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVV 495
Query: 254 VGITEKKAIKRFQI---MNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKD 310
+G F+ +N + I ++ + LVF +RK + A L KD
Sbjct: 496 LGFPCSSNQTEFKFDLTLNYKIASVIQMYSDQKPTLVFCATRKGVQQAASV-----LVKD 550
Query: 311 TLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFGDKHI 370
+ E + L+ A ++ +L+D+L G A HHAGM DR +VE F +
Sbjct: 551 AKFIMTVE---QKQRLQKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDL 607
Query: 371 QVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGE 430
VL +T+TLA GVNLPAH V+IK T Y+ G + E DILQM+GRAGRPQ+DT
Sbjct: 608 PVLFTTSTLAMGVNLPAHLVVIKSTMHYAG--GLFEEYSETDILQMIGRAGRPQFDTTAT 665
Query: 431 GILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDAVNWLGYAYLY 490
+++T Y+ +L + +ES + L + LNAEIVL + + AV W+ LY
Sbjct: 666 AVIMTRLSTRDKYIQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIRSTLLY 725
Query: 491 IRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTGNFQVTELGR 550
IR L++P+ YG + K ++ + +L L +L+K D+ NF+ TE GR
Sbjct: 726 IRALKNPSHYGFASGLNKDG--IEAKLQELCLKNLNDLSSLDLIKMDEGV-NFKPTEAGR 782
Query: 551 IASHYYITNDTVQTYNQLL-KPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLE--- 606
+ + YYIT +TV+ + + K TLS +L + + EF +I +R EK L L +
Sbjct: 783 LMAWYYITFETVKKFYTISGKETLS--DLVTLIAGCKEFLDIQLRINEKKTLNTLNKDPN 840
Query: 607 --RVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIFEIVL 664
+ P++ I+ K+N L+QA + + ++ FAL D + + R+ R + + V
Sbjct: 841 RITIRFPMEGRIKTREMKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDFVA 900
Query: 665 --NRGWAQLTDKTLNLCKMIDKRMWQ-SMCPLRQFRKLPEEVVKKIEKKNF-PFERLYDL 720
+ +A L + +L L K ++W+ S+ +Q K+ + I F+++ +
Sbjct: 901 AQEKKFAVLLN-SLILAKCFRCKLWENSLHVSKQLEKIGITLSNAIVNAGLTSFKKIEET 959
Query: 721 NHNEIGELI--RMPKMGKTIHKYVHLFPKLELSVHLQPITR---STLKVELT-ITPDFQW 774
+ E+ ELI R P G I + V PK EL V + ITR +T ++ +T I +F+
Sbjct: 960 DAREL-ELILNRHPPFGTQIKETVMYLPKYELKV--EQITRYSDTTAEILVTVILRNFEQ 1016
Query: 775 DEKVHGSSEAFWI--LVEDVDSEVILHH---EYFLLKA 807
+ +S++ ++ ++ D D++V+ H + LLKA
Sbjct: 1017 LQTKRTASDSHYVTLIIGDADNQVVYLHKITDSVLLKA 1054
Score = 311 bits (798), Expect = 3e-84
Identities = 244/845 (28%), Positives = 419/845 (49%), Gaps = 60/845 (7%)
Query: 881 FESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNS---- 936
F S++++ FP+FN IQ++ F+ + +D N + APTGSGKT+ E AI R+L++
Sbjct: 271 FRSIFKE-FPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWL 329
Query: 937 EGRCVYITPMRLWQEQVYMDWYEKFQD-RLNKKVVLLTGET-STDLKLLGKGNIIISTPE 994
+ VY+ P++ Q + DW EKF LN K LTG+T DL + +II++TPE
Sbjct: 330 NIKIVYMAPIKALCSQRFDDWKEKFGPIGLNCKE--LTGDTVMDDLFEIQHAHIIMTTPE 387
Query: 995 KWDILSRRWKQRKNVQNINLFVVDEVHLIGGEN-GPVLEVICSRMRYISSQIER------ 1047
KWD ++R+W+ VQ + LF++DEVH++ EN GP LEV+ SRM+ + S +
Sbjct: 388 KWDSMTRKWRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTST 447
Query: 1048 --PIRIVALSSSLSNAKDVAHWL--GCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRL 1103
P+R VA+S+++ NA+D+A WL G + RPV L+ + GF S QT
Sbjct: 448 AIPMRFVAVSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSNQTEF 507
Query: 1104 ---LSMAKPVFHAITKHSPKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKD 1160
L++ + I +S +KP +VF +RK + A + ++ +F+ E+
Sbjct: 508 KFDLTLNYKIASVIQMYSDQKPTLVFCATRKGVQQAASVL-------VKDAKFIMTVEQK 560
Query: 1161 --LIPYLEKLSDSTLKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGM 1218
L Y + DS L++ L +G Y H G+ +R++VE F+ G + V+ + +L G+
Sbjct: 561 QRLQKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGV 620
Query: 1219 NVAAHLVIIMDTLYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFF 1278
N+ AHLV+I T++Y G + + +Y D+LQM+G A RP D VIM + S +D +
Sbjct: 621 NLPAHLVVIKSTMHYAGGL--FEEYSETDILQMIGRAGRPQFDTTATAVIMTRLSTRDKY 678
Query: 1279 KKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNL- 1337
+ L VES L + +H NAEIV TI + AV+++ T LY R +NP++Y
Sbjct: 679 IQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIRSTLLYIRALKNPSHYGFA 738
Query: 1338 QGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLGMIAAYYYINYTTIELFS 1397
G++ + L EL + L+DL I +++ ++ P G + A+YYI + T++ F
Sbjct: 739 SGLNKDGIEAKLQELCLKNLNDLSSLDLIKMDEGVNFKPTEAGRLMAWYYITFETVKKF- 797
Query: 1398 MSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVPHKLN-----NPKFNDPH 1452
+++ K + L+ +I+ E+ +I +R +E L L K P+++ +
Sbjct: 798 YTISGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTL-NKDPNRITIRFPMEGRIKTRE 856
Query: 1453 VKTNLLLQAHLSRMQL-SAELQSDTEEILSKAIRLIQACVD-VLSSNGWLSPALAAMELA 1510
+K N L+QA L + + L DT +I R+ + D V + + L ++ LA
Sbjct: 857 MKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDFVAAQEKKFAVLLNSLILA 916
Query: 1511 QMVTQAMWSEDSYL-RRLPPFPSGLFKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIA 1569
+ +W ++ ++L L + G+ S I E + E +L
Sbjct: 917 KCFRCKLWENSLHVSKQLEKIGITLSNAIVNAGLTSFKKIEETDARELELILNRHPPFGT 976
Query: 1570 DVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWW 1629
+ P EL E + + S + +V ++ E+ T + + +
Sbjct: 977 QIKETVMYLPKYELKVEQITRYSDTTAEILVTVILRNFEQLQT--------KRTASDSHY 1028
Query: 1630 V--VIGDAKSNSLISIKRLT----LQQKAKVKLDFVAPATGGRHNTLYFMSDAYMGCDQE 1683
V +IGDA N ++ + ++T L+ + K V A ++ +S ++G D +
Sbjct: 1029 VTLIIGDA-DNQVVYLHKITDSVLLKAGSWAKKIAVKRALKSEDLSINLISSEFVGLDIQ 1087
Query: 1684 YKFSV 1688
K +V
Sbjct: 1088 QKLTV 1092
>gi|139394648 DNA polymerase theta [Homo sapiens]
Length = 2590
Score = 136 bits (343), Expect = 2e-31
Identities = 136/435 (31%), Positives = 207/435 (47%), Gaps = 66/435 (15%)
Query: 61 ENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFG 120
+NL+ APT AGKT VA + +L+ + + K ++I P S+ +E
Sbjct: 109 KNLVYSAPTSAGKTLVAELLILKRVLEMRK----------KALFILPFVSVAKEKKYYLQ 158
Query: 121 KRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDE 180
GI V G + S+ I VCT E+ + + + E L+ ++V+DE
Sbjct: 159 SLFQEVGIKVDGYMGSTSPSRH-FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDE 217
Query: 181 IHLLHDD-RGPVLEALVARAI---RNIEMTQED--------VRLIGLSATLPNYEDVATF 228
+H+L D RG +LE L+ + R Q D V+++G+SATLPN E VA++
Sbjct: 218 LHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASW 277
Query: 229 LRVDPAKGLFYFDNSFRPVPL-EQTYVGIT----EKKAIKRFQIMNEI----------VY 273
L + L++ D FRPVPL E VG + K ++ F+ M ++ Y
Sbjct: 278 LNAE----LYHTD--FRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCY 331
Query: 274 EKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQC 333
E I ++ + VL+F S+K K A I L + S V+ + E
Sbjct: 332 ETICDN---HSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELL 388
Query: 334 KNLE------------LKDLLPYGFAIHHAGMTRVDRTLVEDLFGDKHIQVLVSTATLAW 381
+ ++ L+ +P+G A HHAG+T +R ++E F I+VL +T+TL+
Sbjct: 389 EVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSS 448
Query: 382 GVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQ 441
GVNLPA VII+ T ++ GR L L QM+GRAGR DT GE ILI + E
Sbjct: 449 GVNLPARRVIIR-TPIFG---GR--PLDILTYKQMVGRAGRKGVDTVGESILICKNSEKS 502
Query: 442 YYLSLLNQQL-PIES 455
++LL L P+ S
Sbjct: 503 KGIALLQGSLKPVRS 517
Score = 115 bits (288), Expect = 4e-25
Identities = 130/498 (26%), Positives = 226/498 (45%), Gaps = 79/498 (15%)
Query: 909 NVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITP-MRLWQEQVYMDWYEKFQDRLNK 967
N+ APT +GKT+ AE IL+ +L+ + + ++I P + + +E+ Y + + +
Sbjct: 110 NLVYSAPTSAGKTLVAELLILKRVLEMRK-KALFILPFVSVAKEKKY--YLQSLFQEVGI 166
Query: 968 KVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGGEN 1027
KV G TS + +I + T E+ + L R + + + + VVDE+H++G +
Sbjct: 167 KVDGYMGSTSPS-RHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSH 225
Query: 1028 -GPVLEVICSRMRYIS-----------SQIERPIRIVALSSSLSNAKDVAHWLGCSATST 1075
G +LE++ +++ YI+ S + ++IV +S++L N + VA WL
Sbjct: 226 RGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAEL--- 282
Query: 1076 FNFHPNVRPVPLELHIQ-GFNISHTQTRLLSMAKPVF-------HAIT--------KHSP 1119
+H + RPVPL ++ G +I + +L+ +P+ H ++ HS
Sbjct: 283 --YHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHS- 339
Query: 1120 KKPVIVFVPSRKQTRLTAIDILTTCAADIQRQ-----RFLHCT-----EKDLIPYLEKLS 1169
V++F PS+K A DI+ ++ Q + C +K+L+ +++L
Sbjct: 340 ---VLLFCPSKKWCEKLA-DIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLR 395
Query: 1170 ------DSTLKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAH 1223
DS L++T+ GV + H GL+ ER ++E F G I+V+ A+ +L G+N+ A
Sbjct: 396 RLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPAR 455
Query: 1224 LVIIMDTLYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLY 1283
VII T + G+ + Y QMVG A R D G +++C+ S+K L
Sbjct: 456 RVIIR-TPIFGGRPLDILTYK-----QMVGRAGRKGVDTVGESILICKNSEKSKGIALLQ 509
Query: 1284 EPL-PVESHLDHCMHDHFNAEIVTKTIE--------NKQDAVDYLTWTFLYRRMTQNPNY 1334
L PV S L + ++ +E QD Y TFL M +
Sbjct: 510 GSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGK-- 567
Query: 1335 YNLQGISHRHLSDHLSEL 1352
QGI S L +
Sbjct: 568 ---QGIQRNQESVQLGAI 582
>gi|110556640 DNA helicase HEL308 [Homo sapiens]
Length = 1101
Score = 129 bits (323), Expect = 3e-29
Identities = 145/585 (24%), Positives = 255/585 (43%), Gaps = 87/585 (14%)
Query: 7 EEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRI----QSKLYRAALETDEN 62
EE++V K S L P LP + + FK + ++ + L +++ +N
Sbjct: 297 EEINVA--KKTVESSSNDLGPFYSLPSKVRDLYAQFKGIEKLYEWQHTCLTLNSVQERKN 354
Query: 63 LLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKR 122
L+ PT GKT VA + ML+E+ D ++ I P ++VQE +
Sbjct: 355 LIYSLPTSGGKTLVAEILMLQEL-LCCRKD---------VLMILPYVAIVQEKISG---- 400
Query: 123 LATYGITVAELTGDHQLCKEEISATQ------IIVCTPEKWDIITRKGGERTYTQLVRLI 176
L+++GI + ++ K T+ + + T EK + E + L+
Sbjct: 401 LSSFGIELGFFVEEYAGSKGRFPPTKRREKKSLYIATIEKGHSLVNSLIETGRIDSLGLV 460
Query: 177 VLDEIHLLHD-DRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAK 235
V+DE+H++ + RG LE +A+ + + TQ +IG+SATL N ED+ FL+ +
Sbjct: 461 VVDELHMIGEGSRGATLEMTLAKILYTSKTTQ----IIGMSATLNNVEDLQKFLQAE--- 513
Query: 236 GLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQV---------- 285
Y+ + FRPV L++ Y+ I + + N + + +++ + + +
Sbjct: 514 ---YYTSQFRPVELKE-YLKINDTIYEVDSKAENGMTFSRLLNYKYSDTLKKMDPDHLVA 569
Query: 286 -----------LVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCK 334
LVF S+K A I L K+ L +E + L+
Sbjct: 570 LVTEVIPNYSCLVFCPSKKNCENVAEMICKF-LSKEYLKHKEKEKCEVIKNLKNIGNGNL 628
Query: 335 NLELKDLLPYGFAIHHAGMTRVDRTLVEDLFGDKHIQVLVSTATLAWGVNLPAHTVIIKG 394
LK +P+G A HH+G+T +R L+E+ + + + T+TLA GVNLPA VI++
Sbjct: 629 CPVLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRA 688
Query: 395 TQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLP-- 452
V L QM+GRAGR DT GE ILI + Q L L+ + L
Sbjct: 689 PYVAK------EFLKRNQYKQMIGRAGRAGIDTIGESILILQEKDKQQVLELITKPLENC 742
Query: 453 ---IESQMVSKLPDMLNAEIVLGNVQNAKDAVNWLGYAYLYIR---MLRSPTLYGISHDD 506
+ + + + + I L N D +++ + ++ +L+ +L+ I+ +
Sbjct: 743 YSHLVQEFTKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQQKVLLKEKSLWEITVES 802
Query: 507 LKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTG-NFQVTELGR 550
L+ T +L K+ + K +++ NF +T+LGR
Sbjct: 803 LR------------YLTEKGLLQKDTIYKSEEEVQYNFHITKLGR 835
Score = 90.5 bits (223), Expect = 1e-17
Identities = 109/453 (24%), Positives = 189/453 (41%), Gaps = 63/453 (13%)
Query: 909 NVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITPMRLWQEQVYMDWYEKFQDRLNKK 968
N+ PT GKT+ AE +L+ LL + + + + + QE++ F L
Sbjct: 354 NLIYSLPTSGGKTLVAEILMLQELLCCRKDVLMILPYVAIVQEKI--SGLSSFGIELGFF 411
Query: 969 VVLLTGETST--DLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIG-G 1025
V G K K ++ I+T EK L + + ++ L VVDE+H+IG G
Sbjct: 412 VEEYAGSKGRFPPTKRREKKSLYIATIEKGHSLVNSLIETGRIDSLGLVVVDELHMIGEG 471
Query: 1026 ENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLGCSA-TSTFNFHPNVRP 1084
G LE+ +++ Y S + +I+ +S++L+N +D+ +L TS F RP
Sbjct: 472 SRGATLEMTLAKILYTS----KTTQIIGMSATLNNVEDLQKFLQAEYYTSQF------RP 521
Query: 1085 VPLELHIQG--------------------FNISHTQTRLLSMAKPVFHAITKHSPKKPVI 1124
V L+ +++ N ++ T + +T+ P +
Sbjct: 522 VELKEYLKINDTIYEVDSKAENGMTFSRLLNYKYSDTLKKMDPDHLVALVTEVIPNYSCL 581
Query: 1125 VFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSD-------STLKETL 1177
VF PS+K A I + + +L EK+ ++ L + LK T+
Sbjct: 582 VFCPSKKNCENVAEMICKFLSKE-----YLKHKEKEKCEVIKNLKNIGNGNLCPVLKRTI 636
Query: 1178 LNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTLYYNGKI 1237
GV Y H GL+ ER+L+E+ +S+G + + + +L G+N+ A VI+ Y +
Sbjct: 637 PFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILR-APYVAKEF 695
Query: 1238 HAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMH 1297
Y QM+G A R D G +++ Q K + + +PL E+ H +
Sbjct: 696 LKRNQYK-----QMIGRAGRAGIDTIGESILILQEKDKQQVLELITKPL--ENCYSHLVQ 748
Query: 1298 DH-------FNAEIVTKTIENKQDAVDYLTWTF 1323
+ F + I K N D ++ TF
Sbjct: 749 EFTKGIQTLFLSLIGLKIATNLDDIYHFMNGTF 781
>gi|67782311 superkiller viralicidic activity 2-like homolog [Homo
sapiens]
Length = 1246
Score = 107 bits (268), Expect = 8e-23
Identities = 125/494 (25%), Positives = 211/494 (42%), Gaps = 82/494 (16%)
Query: 856 PEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPF-FNPIQTQVFNTVY-NSDDNVFVG 913
PE PP++ P+ ++ + + Q F + F P Q ++ D+VFV
Sbjct: 272 PEAPEPPSQEQWAIPVDATSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLERHDSVFVA 331
Query: 914 APTGSGKTICAEFAILRMLLQNSEGRCVYITPMRLWQEQVYMDWYEKFQDRLNKKVVLLT 973
A T +GKT+ AE+AI L Q R +Y +P++ Q + D+ F D V LLT
Sbjct: 332 AHTSAGKTVVAEYAI--ALAQKHMTRTIYTSPIKALSNQKFRDFRNTFGD-----VGLLT 384
Query: 974 GETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGG-ENGPVLE 1032
G D++L + + +I T E + S + ++++ + DEVH I E G V E
Sbjct: 385 G----DVQLHPEASCLIMTTE--ILRSMLYSGSDVIRDLEWVIFDEVHYINDVERGVVWE 438
Query: 1033 VICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLG-CSATSTFNFHPNVRPVPLELHI 1091
+ + + I+ LS+++ NA + A W+G + RPVPLE ++
Sbjct: 439 EVL-------IMLPDHVSIILLSATVPNALEFADWIGRLKRRQIYVISTVTRPVPLEHYL 491
Query: 1092 QGFNISHTQTRLLSM--AKPVFHA-------------ITKHS------------------ 1118
N S TQ L + ++ FH ++KH+
Sbjct: 492 FTGNSSKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDR 551
Query: 1119 -------------PKKPVIVFVPSR-----KQTRLTAIDILTTCAADIQRQRFLHCTEKD 1160
+ PV+VF SR + + LT++D LTT + + FL
Sbjct: 552 GVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLD-LTTSSEKSEIHLFLQRCLAR 610
Query: 1161 LIPYLEKLSDSTLKETLLN-GVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMN 1219
L +L LLN G+G H G+ P+ + +VE LFS G ++V+ A+ + G+N
Sbjct: 611 LRGSDRQLPQVLHMSELLNRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVN 670
Query: 1220 VAAHLVIIMDTLYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQG---SKKD 1276
+ A V+ ++G + D + +QM G A R D G +++C+G D
Sbjct: 671 MPARTVVFDSMRKHDGS--TFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMAD 728
Query: 1277 FFKKFLYEPLPVES 1290
+ + +P ++S
Sbjct: 729 LHRMMMGKPSQLQS 742
Score = 96.7 bits (239), Expect = 2e-19
Identities = 110/429 (25%), Positives = 183/429 (42%), Gaps = 83/429 (19%)
Query: 57 LETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMV 116
LE +++ + A T AGKT VA + KH+ + IY +P+++L +
Sbjct: 322 LERHDSVFVAAHTSAGKTVVAEYAIALA-QKHMT----------RTIYTSPIKALSNQKF 370
Query: 117 GSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLI 176
F G+ LTGD QL E ++ T E + G + + + +
Sbjct: 371 RDFRNTFGDVGL----LTGDVQLHPE----ASCLIMTTEILRSMLYSGSD--VIRDLEWV 420
Query: 177 VLDEIHLLHD-DRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAK 235
+ DE+H ++D +RG V E ++ M + V +I LSAT+PN + A ++ +
Sbjct: 421 IFDEVHYINDVERGVVWEEVLI-------MLPDHVSIILLSATVPNALEFADWIGRLKRR 473
Query: 236 GLFYFDNSFRPVPLEQ-TYVGITEKKAIKRFQIMN--------------EIVYEKIMEHA 280
++ RPVPLE + G + K + F +++ E E++ +HA
Sbjct: 474 QIYVISTVTRPVPLEHYLFTGNSSKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHA 533
Query: 281 ---GKNQ----------------------------VLVFVHSRKETGKTARAIRDMCL-- 307
G Q V+VF SR + A + + L
Sbjct: 534 QTFGAKQPTHQGGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTT 593
Query: 308 --EKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLF 365
EK + LFL+ A + Q L + +LL G +HH+G+ + + +VE LF
Sbjct: 594 SSEKSEIHLFLQRCLARLRGSDRQLPQV--LHMSELLNRGLGVHHSGILPILKEIVEMLF 651
Query: 366 GDKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQY 425
++VL +T T A GVN+PA TV+ + + + + +L + +QM GRAGR
Sbjct: 652 SRGLVKVLFATETFAMGVNMPARTVVFDSMRKH--DGSTFRDLLPGEYVQMAGRAGRRGL 709
Query: 426 DTKGEGILI 434
D G IL+
Sbjct: 710 DPTGTVILL 718
>gi|193211480 superkiller viralicidic activity 2-like 2 [Homo sapiens]
Length = 1042
Score = 91.7 bits (226), Expect = 6e-18
Identities = 110/461 (23%), Positives = 190/461 (41%), Gaps = 78/461 (16%)
Query: 888 KFPFF-NPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITPM 946
++PF + Q + V N+ +V V A T +GKT+CAE+AI L + R ++ +P+
Sbjct: 135 EYPFILDAFQREAIQCVDNNQ-SVLVSAHTSAGKTVCAEYAIALALREKQ--RVIFTSPI 191
Query: 947 RLWQEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQR 1006
+ Q Y + YE+FQD V L+TG D+ + + ++ T E + S ++
Sbjct: 192 KALSNQKYREMYEEFQD-----VGLMTG----DVTINPTASCLVMTTE--ILRSMLYRGS 240
Query: 1007 KNVQNINLFVVDEVHLI-GGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVA 1065
+ ++ + + DE+H + E G V E + + V LS+++ NA+ A
Sbjct: 241 EVMREVAWVIFDEIHYMRDSERGVVWEETI-------ILLPDNVHYVFLSATIPNARQFA 293
Query: 1066 HWL-GCSATSTFNFHPNVRPVPLELHI-----QGFNI------------SHTQTRLLSMA 1107
W+ + + RP PL+ +I G ++ +T ++L A
Sbjct: 294 EWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDA 353
Query: 1108 ------------------KPVFHAITKHSPK--KPVIVFVPSRKQTRLTAIDILTTCAAD 1147
VF + + +PVI+F S+K A+ + D
Sbjct: 354 GDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQM---TKLD 410
Query: 1148 IQRQRFLHCTEKDLIPYLEKLSDSTLK--------ETLLNGVGYLHEGLSPMERRLVEQL 1199
E+ ++ LSD K L G+G H GL P+ + +E L
Sbjct: 411 FNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEIL 470
Query: 1200 FSSGAIQVVVASRSLCWGMNVAAHLVIIMDTLYYNGKIHAYVDYPIYDVLQMVGHANRPL 1259
FS G I+ + A+ + G+N+ A V+ + ++GK ++ Y +QM G A R
Sbjct: 471 FSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEY--IQMSGRAGRRG 528
Query: 1260 QDDEGRCVIMCQGSKKDFFKKFLY----EPLPVESHLDHCM 1296
DD G ++M K L +PL HL + M
Sbjct: 529 MDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNM 569
Score = 86.3 bits (212), Expect = 2e-16
Identities = 104/458 (22%), Positives = 190/458 (41%), Gaps = 81/458 (17%)
Query: 21 SEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKT---NVA 77
+EE LP++ P+ +A E L+ Q + + ++ ++++L+ A T AGKT A
Sbjct: 118 AEEDYLPLK--PRVGKAAKEYPFILDAFQREAIQC-VDNNQSVLVSAHTSAGKTVCAEYA 174
Query: 78 LMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDH 137
+ LRE ++I+ +P+++L + + G+ ++T +
Sbjct: 175 IALALRE--------------KQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTIN- 219
Query: 138 QLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDEIHLLHD-DRGPVLEALV 196
+V T E + +G E + V ++ DEIH + D +RG V E
Sbjct: 220 -------PTASCLVMTTEILRSMLYRGSE--VMREVAWVIFDEIHYMRDSERGVVWE--- 267
Query: 197 ARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQ----- 251
I + ++V + LSAT+PN A ++ + +RP PL+
Sbjct: 268 ----ETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIFPA 323
Query: 252 ----TYVGITEKKAIKR------FQIMNEI-----------------------VYEKIME 278
++ + E + Q++ + + + IME
Sbjct: 324 GGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIME 383
Query: 279 HAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREG-SASTEVLRTEAEQCKNLE 337
V++F S+K+ A + + D + E S + + L E ++ +E
Sbjct: 384 R-NFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVE 442
Query: 338 -LKDLLPYGFAIHHAGMTRVDRTLVEDLFGDKHIQVLVSTATLAWGVNLPAHTVIIKGTQ 396
+ LL G IHH G+ + + +E LF + I+ L +T T A G+N+PA TV+ +
Sbjct: 443 HVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNAR 502
Query: 397 VYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILI 434
+ + RW G + +QM GRAGR D +G IL+
Sbjct: 503 KFDGKDFRWISSG--EYIQMSGRAGRRGMDDRGIVILM 538
>gi|6005872 SEC63-like protein [Homo sapiens]
Length = 760
Score = 66.6 bits (161), Expect = 2e-10
Identities = 35/93 (37%), Positives = 56/93 (60%), Gaps = 3/93 (3%)
Query: 1605 LEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSNSLISIKR--LTLQQKAKVKLDFVAPA 1662
LE + ++T PV + FP++++E WW+ I D K +LIS+ TL+ +V+L F AP
Sbjct: 628 LETKSKITHPVYSLYFPEEKQEWWWLYIADRKEQTLISMPYHVCTLKDTEEVELKFPAPG 687
Query: 1663 TGGRHN-TLYFMSDAYMGCDQEYKFSVDVKEAE 1694
G + T++ SD+YMG DQ ++V EA+
Sbjct: 688 KPGNYQYTVFLRSDSYMGLDQIKPLKLEVHEAK 720
Score = 65.5 bits (158), Expect = 4e-10
Identities = 61/253 (24%), Positives = 124/253 (49%), Gaps = 32/253 (12%)
Query: 1388 INYTTIELFSMSLNAKTKVRGLIEIISNAAEYE-----NIPIRHHEDNLLRQLAQKVPH- 1441
I T I + + ++ LI +++ A+E++ + R ++ L+ QL +++
Sbjct: 225 IRTTQIYTYFVYKTRNMDMKRLIMVLAGASEFDPQYNKDATSRPTDNILIPQLIREIGSI 284
Query: 1442 --KLNNPKFNDPH-VKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVL---- 1494
K N P P+ +K +LL +HL+RM++ L+ D + +L K L+Q V+V+
Sbjct: 285 NLKKNEPPLTCPYSLKARVLLLSHLARMKIPETLEEDQQFMLKKCPALLQEMVNVICQLI 344
Query: 1495 ------SSNGWLSPALAAME----LAQMVTQAMWSEDSYLRRLPPFPSGLFKRCTDK--- 1541
+ +P LA++E L+QM Q + S L +LP +R ++
Sbjct: 345 VMARNREEREFRAPTLASLENCMKLSQMAVQGLQQFKSPLLQLPHIEEDNLRRVSNHKKY 404
Query: 1542 GVESVFDIMEMEDEERNALLQ-LTDSQIADVARFCNRYP--NIELSYEVV---DKDSIRS 1595
++++ D++ +++ +R+ LL L D + +V +P +++ +V+ D ++I
Sbjct: 405 KIKTIQDLVSLKESDRHTLLHFLEDEKYEEVMAVLGSFPYVTMDIKSQVLDDEDSNNITV 464
Query: 1596 GGPVVVLVQLERE 1608
G V VLV+L R+
Sbjct: 465 GSLVTVLVKLTRQ 477
>gi|222831595 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 [Homo sapiens]
Length = 1712
Score = 65.1 bits (157), Expect = 6e-10
Identities = 63/241 (26%), Positives = 106/241 (43%), Gaps = 25/241 (10%)
Query: 195 LVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYV 254
L+ +R +E L L A E V+TFL+ + P ++ +V
Sbjct: 1116 LLVEKLRKMEKLPALFFLFKLGAVENAAESVSTFLKKKQ-------ETKRPPKADKEAHV 1168
Query: 255 GITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGL 314
+ + +K+ +I+ EK + +N +H + +++ + +D
Sbjct: 1169 MANKLRKVKKSIEKQKIIDEKSQKKT-RNVDQSLIHEAEHDNLVKCLEKNLEIPQDCT-- 1225
Query: 315 FLREGSASTEVL-----RTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFGDKH 369
+ + + TE L R + E+ K ELK L G HH+ M+ ++ LVE LF +
Sbjct: 1226 YADQKAVDTETLQKVFGRVKFER-KGEELKALAERGIGYHHSAMSFKEKQLVEILFRKGY 1284
Query: 370 IQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKG 429
++V+ +T TLA GVN+P +V+ VY L AL+ QM GRAGR D G
Sbjct: 1285 LRVVTATGTLALGVNMPCKSVVFAQNSVY---------LDALNYRQMSGRAGRRGQDLMG 1335
Query: 430 E 430
+
Sbjct: 1336 D 1336
Score = 59.7 bits (143), Expect = 2e-08
Identities = 43/166 (25%), Positives = 78/166 (46%), Gaps = 8/166 (4%)
Query: 903 VYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITPMRLWQEQVYMDWYEKFQ 962
V + +++ + APT SGKT + + + ++L ++ +G VY+ P + QV +F
Sbjct: 774 VVDKNESAVIVAPTSSGKTYASYYCMEKVLKESDDGVVVYVAPTKALVNQVAATVQNRFT 833
Query: 963 DRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHL 1022
L VL T ++I+ P ++IL ++ V+ I + DEVH
Sbjct: 834 KNLPSGEVLCGVFTREYRHDALNCQVLITVPACFEILLLAPHRQNWVKKIRYVIFDEVHC 893
Query: 1023 IGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWL 1068
+GGE G + ++ I P +ALS+++SN + + WL
Sbjct: 894 LGGEIGAEI------WEHLLVMIRCP--FLALSATISNPEHLTEWL 931
Score = 53.9 bits (128), Expect = 1e-06
Identities = 38/178 (21%), Positives = 84/178 (47%), Gaps = 24/178 (13%)
Query: 57 LETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMV 116
++ +E+ ++ APT +GKT + CM + + + DD ++Y+AP ++LV ++
Sbjct: 775 VDKNESAVIVAPTSSGKTYASYYCMEKVLKES---------DDGVVVYVAPTKALVNQVA 825
Query: 117 GS----FGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQL 172
+ F K L + + T ++ + + Q+++ P ++I+ + + +
Sbjct: 826 ATVQNRFTKNLPSGEVLCGVFTREY---RHDALNCQVLITVPACFEILLLAPHRQNWVKK 882
Query: 173 VRLIVLDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLR 230
+R ++ DE+H L + G + + IR + LSAT+ N E + +L+
Sbjct: 883 IRYVIFDEVHCLGGEIGAEIWEHLLVMIR--------CPFLALSATISNPEHLTEWLQ 932
Score = 44.7 bits (104), Expect = 8e-04
Identities = 45/169 (26%), Positives = 72/169 (42%), Gaps = 36/169 (21%)
Query: 1116 KHSPKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDL-IP----YLEKLSD 1170
K S +K I+ S+K+TR ++ + + + + C EK+L IP Y ++ +
Sbjct: 1177 KKSIEKQKIIDEKSQKKTR----NVDQSLIHEAEHDNLVKCLEKNLEIPQDCTYADQKAV 1232
Query: 1171 ST------------------LKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASR 1212
T LK G+GY H +S E++LVE LF G ++VV A+
Sbjct: 1233 DTETLQKVFGRVKFERKGEELKALAERGIGYHHSAMSFKEKQLVEILFRKGYLRVVTATG 1292
Query: 1213 SLCWGMNVAAHLVIIMDTLYYNGKIHAYVDYPIYDVLQMVGHANRPLQD 1261
+L G+N+ V+ Y + + QM G A R QD
Sbjct: 1293 TLALGVNMPCKSVVFAQNSVYLDAL---------NYRQMSGRAGRRGQD 1332
>gi|149274648 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Homo
sapiens]
Length = 1706
Score = 53.9 bits (128), Expect = 1e-06
Identities = 35/93 (37%), Positives = 47/93 (50%), Gaps = 9/93 (9%)
Query: 337 ELKDLLPYGFAIHHAGMTRVDRTLVEDLFGDKHIQVLVSTATLAWGVNLPAHTVIIKGTQ 396
ELK L G HH+ M ++ VE LF I+V+ +T TLA G+++P +V+
Sbjct: 1236 ELKALAQRGIGYHHSSMYFKEKEFVEILFVKGLIRVVTATETLALGIHMPCKSVVFAQDS 1295
Query: 397 VYSPEKGRWTELGALDILQMLGRAGRPQYDTKG 429
VY L AL+ QM GRAGR D G
Sbjct: 1296 VY---------LDALNYRQMSGRAGRRGQDLLG 1319
Score = 52.8 bits (125), Expect = 3e-06
Identities = 46/168 (27%), Positives = 76/168 (45%), Gaps = 8/168 (4%)
Query: 886 QDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITP 945
QD P N Q ++ + V ++ V V APT SGKT + + + ++L ++ G VY+ P
Sbjct: 740 QDFIP--NAWQQELLDVVDKNESAVIV-APTSSGKTYASYYCMEKVLRESDVGVVVYVAP 796
Query: 946 MRLWQEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQ 1005
+ QV +F L L T + ++I+ PE ++IL +
Sbjct: 797 AKSLVGQVAATVENRFTKTLPAGRTLCGAFTRDYCHNVLNCQVLITVPECFEILLLAPHR 856
Query: 1006 RKNVQNINLFVVDEVHLIGGENGP-----VLEVICSRMRYISSQIERP 1048
+K V+ I + DEVH +G E G +L +I +S+ I P
Sbjct: 857 QKWVERIRYVIFDEVHYLGREVGAKFWELLLVIIRCPFLVLSATINNP 904
Score = 50.4 bits (119), Expect = 1e-05
Identities = 35/149 (23%), Positives = 72/149 (48%), Gaps = 16/149 (10%)
Query: 57 LETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMV 116
++ +E+ ++ APT +GKT + CM + + + + V ++Y+AP +SLV ++
Sbjct: 755 VDKNESAVIVAPTSSGKTYASYYCM-----EKVLRESDVGV----VVYVAPAKSLVGQVA 805
Query: 117 GS----FGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQL 172
+ F K L T D+ C ++ Q+++ PE ++I+ + + +
Sbjct: 806 ATVENRFTKTLPAGRTLCGAFTRDY--CHNVLNC-QVLITVPECFEILLLAPHRQKWVER 862
Query: 173 VRLIVLDEIHLLHDDRGPVLEALVARAIR 201
+R ++ DE+H L + G L+ IR
Sbjct: 863 IRYVIFDEVHYLGREVGAKFWELLLVIIR 891
Score = 40.0 bits (92), Expect = 0.019
Identities = 28/90 (31%), Positives = 42/90 (46%), Gaps = 11/90 (12%)
Query: 1173 LKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVII-MDTL 1231
LK G+GY H + E+ VE LF G I+VV A+ +L G+++ V+ D++
Sbjct: 1237 LKALAQRGIGYHHSSMYFKEKEFVEILFVKGLIRVVTATETLALGIHMPCKSVVFAQDSV 1296
Query: 1232 YYNGKIHAYVDYPIYDVLQMVGHANRPLQD 1261
Y + + QM G A R QD
Sbjct: 1297 YLDA----------LNYRQMSGRAGRRGQD 1316
>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
sapiens]
Length = 1031
Score = 46.2 bits (108), Expect = 3e-04
Identities = 48/170 (28%), Positives = 76/170 (44%), Gaps = 15/170 (8%)
Query: 56 ALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKI-IYIAPMRSLVQE 114
A+ + +L+ A TG+GKT L+ M R HI ++ + I + + P R L +
Sbjct: 405 AIMSGRDLIGIAKTGSGKTIAFLLPMFR----HIMDQRSLEEGEGPIAVIMTPTRELALQ 460
Query: 115 MVGSFGKRLATYGITVAEL---TGDHQLCKEEISATQIIVCTPEKW-DIITRKGGERTYT 170
+ K T G+ V + TG + E +IIVCTP + D++ G T
Sbjct: 461 ITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNL 520
Query: 171 QLVRLIVLDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLP 220
+ V +VLDE + D E V R + N+ + D + + SAT P
Sbjct: 521 RRVTYVVLDEADRMFD---MGFEPQVMRIVDNV---RPDRQTVMFSATFP 564
>gi|148612816 RecQ protein-like 5 isoform 1 [Homo sapiens]
Length = 991
Score = 45.1 bits (105), Expect = 6e-04
Identities = 90/413 (21%), Positives = 156/413 (37%), Gaps = 104/413 (25%)
Query: 38 GFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINV 97
GF+ FKT +Q A ++ ++++ +C PTGAGK+ + L + K I
Sbjct: 25 GFDSFKT--PLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPAL--LAKGIT------- 73
Query: 98 DDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTG--DHQLCKE-------EISATQ 148
I ++P+ +L+Q+ V L T + V+ L Q KE E T+
Sbjct: 74 -----IVVSPLIALIQDQVD----HLLTLKVRVSSLNSKLSAQERKELLADLEREKPQTK 124
Query: 149 IIVCTPEKWDIITRKGGERTYTQLVR-----LIVLDEIHLL----HDDRGPVLEALVARA 199
I+ TPE + + T LV +V+DE H + HD R L R+
Sbjct: 125 ILYITPE---MAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRS 181
Query: 200 IRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEK 259
+ + +AT EDV L + +F K
Sbjct: 182 ----RLGHAPCVALTATATPQVQEDVFAALHLKKPVAIF--------------------K 217
Query: 260 KAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREG 319
R + ++ +++++ N ++D CL+ LG +G
Sbjct: 218 TPCFRANLFYDVQFKELISDPYGN------------------LKDFCLK--ALGQEADKG 257
Query: 320 SASTEVLRTEA-EQCKNLELK-DLLPYGFAIHHAGMTRVDRTLVEDLFGDKHIQVLVSTA 377
+ ++ E C+ L ++ +HAG+ +RTLV++ + ++ + V+V+T
Sbjct: 258 LSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVATI 317
Query: 378 TLAWGVN-----LPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQY 425
+ GV+ AH I K Y E GR GR G+P +
Sbjct: 318 SFGMGVDKANVRFVAHWNIAKSMAGYYQESGR------------AGRDGKPSW 358
Score = 33.5 bits (75), Expect = 1.8
Identities = 20/64 (31%), Positives = 34/64 (53%), Gaps = 6/64 (9%)
Query: 891 FFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITPM-RLW 949
F P+Q V + +VFV PTG+GK++C + L ++G + ++P+ L
Sbjct: 29 FKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALL-----AKGITIVVSPLIALI 83
Query: 950 QEQV 953
Q+QV
Sbjct: 84 QDQV 87
>gi|51242943 RecQ protein-like 5 isoform 3 [Homo sapiens]
Length = 410
Score = 45.1 bits (105), Expect = 6e-04
Identities = 90/413 (21%), Positives = 156/413 (37%), Gaps = 104/413 (25%)
Query: 38 GFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINV 97
GF+ FKT +Q A ++ ++++ +C PTGAGK+ + L + K I
Sbjct: 25 GFDSFKT--PLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPAL--LAKGIT------- 73
Query: 98 DDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTG--DHQLCKE-------EISATQ 148
I ++P+ +L+Q+ V L T + V+ L Q KE E T+
Sbjct: 74 -----IVVSPLIALIQDQVD----HLLTLKVRVSSLNSKLSAQERKELLADLEREKPQTK 124
Query: 149 IIVCTPEKWDIITRKGGERTYTQLVR-----LIVLDEIHLL----HDDRGPVLEALVARA 199
I+ TPE + + T LV +V+DE H + HD R L R+
Sbjct: 125 ILYITPE---MAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRS 181
Query: 200 IRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEK 259
+ + +AT EDV L + +F K
Sbjct: 182 ----RLGHAPCVALTATATPQVQEDVFAALHLKKPVAIF--------------------K 217
Query: 260 KAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREG 319
R + ++ +++++ N ++D CL+ LG +G
Sbjct: 218 TPCFRANLFYDVQFKELISDPYGN------------------LKDFCLK--ALGQEADKG 257
Query: 320 SASTEVLRTEA-EQCKNLELK-DLLPYGFAIHHAGMTRVDRTLVEDLFGDKHIQVLVSTA 377
+ ++ E C+ L ++ +HAG+ +RTLV++ + ++ + V+V+T
Sbjct: 258 LSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVATI 317
Query: 378 TLAWGVN-----LPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQY 425
+ GV+ AH I K Y E GR GR G+P +
Sbjct: 318 SFGMGVDKANVRFVAHWNIAKSMAGYYQESGR------------AGRDGKPSW 358
Score = 33.5 bits (75), Expect = 1.8
Identities = 20/64 (31%), Positives = 34/64 (53%), Gaps = 6/64 (9%)
Query: 891 FFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITPM-RLW 949
F P+Q V + +VFV PTG+GK++C + L ++G + ++P+ L
Sbjct: 29 FKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALL-----AKGITIVVSPLIALI 83
Query: 950 QEQV 953
Q+QV
Sbjct: 84 QDQV 87
>gi|51242947 RecQ protein-like 5 isoform 2 [Homo sapiens]
Length = 435
Score = 45.1 bits (105), Expect = 6e-04
Identities = 90/413 (21%), Positives = 156/413 (37%), Gaps = 104/413 (25%)
Query: 38 GFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINV 97
GF+ FKT +Q A ++ ++++ +C PTGAGK+ + L + K I
Sbjct: 25 GFDSFKT--PLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPAL--LAKGIT------- 73
Query: 98 DDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTG--DHQLCKE-------EISATQ 148
I ++P+ +L+Q+ V L T + V+ L Q KE E T+
Sbjct: 74 -----IVVSPLIALIQDQVD----HLLTLKVRVSSLNSKLSAQERKELLADLEREKPQTK 124
Query: 149 IIVCTPEKWDIITRKGGERTYTQLVR-----LIVLDEIHLL----HDDRGPVLEALVARA 199
I+ TPE + + T LV +V+DE H + HD R L R+
Sbjct: 125 ILYITPE---MAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRS 181
Query: 200 IRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEK 259
+ + +AT EDV L + +F K
Sbjct: 182 ----RLGHAPCVALTATATPQVQEDVFAALHLKKPVAIF--------------------K 217
Query: 260 KAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREG 319
R + ++ +++++ N ++D CL+ LG +G
Sbjct: 218 TPCFRANLFYDVQFKELISDPYGN------------------LKDFCLK--ALGQEADKG 257
Query: 320 SASTEVLRTEA-EQCKNLELK-DLLPYGFAIHHAGMTRVDRTLVEDLFGDKHIQVLVSTA 377
+ ++ E C+ L ++ +HAG+ +RTLV++ + ++ + V+V+T
Sbjct: 258 LSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVATI 317
Query: 378 TLAWGVN-----LPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQY 425
+ GV+ AH I K Y E GR GR G+P +
Sbjct: 318 SFGMGVDKANVRFVAHWNIAKSMAGYYQESGR------------AGRDGKPSW 358
Score = 33.5 bits (75), Expect = 1.8
Identities = 20/64 (31%), Positives = 34/64 (53%), Gaps = 6/64 (9%)
Query: 891 FFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITPM-RLW 949
F P+Q V + +VFV PTG+GK++C + L ++G + ++P+ L
Sbjct: 29 FKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALL-----AKGITIVVSPLIALI 83
Query: 950 QEQV 953
Q+QV
Sbjct: 84 QDQV 87
>gi|27886568 interferon induced with helicase C domain 1 [Homo
sapiens]
Length = 1025
Score = 43.1 bits (100), Expect = 0.002
Identities = 47/194 (24%), Positives = 88/194 (45%), Gaps = 15/194 (7%)
Query: 35 AQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGT 94
A+A E L Q ++ + ALE +N+++C PTG+GKT VA+ + K
Sbjct: 298 ARASPEPELQLRPYQMEVAQPALE-GKNIIICLPTGSGKTRVAVYIAKDHLDKKKKAS-- 354
Query: 95 INVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQL---CKEEISATQIIV 151
+ K+I + LV+++ + V L+GD QL E + + II+
Sbjct: 355 ---EPGKVIVLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIII 411
Query: 152 CTPE--KWDIITRKGGERTYTQL--VRLIVLDEIHLLHDDR--GPVLEALVARAIRNIEM 205
T + + ++ + GE QL LI++DE H + + ++ + + ++N +
Sbjct: 412 STAQILENSLLNLENGEDAGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLKNNRL 471
Query: 206 TQEDVRLIGLSATL 219
+E+ +I L L
Sbjct: 472 KKENKPVIPLPQIL 485
Score = 32.7 bits (73), Expect = 3.1
Identities = 34/126 (26%), Positives = 64/126 (50%), Gaps = 16/126 (12%)
Query: 909 NVFVGAPTGSGKTICAEFAILRMLLQNSE----GRCVYITPMRLWQEQVYMDWYEKFQDR 964
N+ + PTGSGKT A + L + + G+ + + L EQ++ ++FQ
Sbjct: 324 NIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVIVLVNKVLLVEQLFR---KEFQPF 380
Query: 965 LNK--KVVLLTGETSTDL---KLLGKGNIIISTPE--KWDILSRRWKQRKNVQ--NINLF 1015
L K +V+ L+G+T + +++ +IIIST + + +L+ + VQ + +L
Sbjct: 381 LKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENSLLNLENGEDAGVQLSDFSLI 440
Query: 1016 VVDEVH 1021
++DE H
Sbjct: 441 IIDECH 446
>gi|29294649 dicer1 [Homo sapiens]
Length = 1922
Score = 42.0 bits (97), Expect = 0.005
Identities = 48/223 (21%), Positives = 95/223 (42%), Gaps = 28/223 (12%)
Query: 12 PALKPKPFGSEEQLLPVEK-------LPKYAQAGFEGFKTLNRIQSKLYRAALETDENLL 64
PAL+P + + P LP +A + T + Q +L AAL D N +
Sbjct: 4 PALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAAL--DHNTI 61
Query: 65 LCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSF----G 120
+C TG+GKT +A++ + +E+ I G + + + +++ + V + V +
Sbjct: 62 VCLNTGSGKTFIAVL-LTKELSYQIR--GDFSRNGKRTVFLVNSANQVAQQVSAVRTHSD 118
Query: 121 KRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQL--VRLIVL 178
++ Y + + +E + Q+++ T + + G Y L + L+V
Sbjct: 119 LKVGEYSNLEVNASWTKERWNQEFTKHQVLIMTCYVALNVLKNG----YLSLSDINLLVF 174
Query: 179 DEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPN 221
DE HL +L+ ++ E R++GL+A++ N
Sbjct: 175 DECHL------AILDHPYREIMKLCENCPSCPRILGLTASILN 211
>gi|29294651 dicer1 [Homo sapiens]
Length = 1922
Score = 42.0 bits (97), Expect = 0.005
Identities = 48/223 (21%), Positives = 95/223 (42%), Gaps = 28/223 (12%)
Query: 12 PALKPKPFGSEEQLLPVEK-------LPKYAQAGFEGFKTLNRIQSKLYRAALETDENLL 64
PAL+P + + P LP +A + T + Q +L AAL D N +
Sbjct: 4 PALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAAL--DHNTI 61
Query: 65 LCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSF----G 120
+C TG+GKT +A++ + +E+ I G + + + +++ + V + V +
Sbjct: 62 VCLNTGSGKTFIAVL-LTKELSYQIR--GDFSRNGKRTVFLVNSANQVAQQVSAVRTHSD 118
Query: 121 KRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQL--VRLIVL 178
++ Y + + +E + Q+++ T + + G Y L + L+V
Sbjct: 119 LKVGEYSNLEVNASWTKERWNQEFTKHQVLIMTCYVALNVLKNG----YLSLSDINLLVF 174
Query: 179 DEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPN 221
DE HL +L+ ++ E R++GL+A++ N
Sbjct: 175 DECHL------AILDHPYREIMKLCENCPSCPRILGLTASILN 211
>gi|38569503 ATP-dependent RNA helicase ROK1 isoform b [Homo sapiens]
Length = 491
Score = 41.6 bits (96), Expect = 0.007
Identities = 58/269 (21%), Positives = 114/269 (42%), Gaps = 24/269 (8%)
Query: 876 LRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQ- 934
+ + +++ F PIQ Q + + + + APTGSGKT+ IL L Q
Sbjct: 64 INSRLLQNILDAGFQMPTPIQMQAIPVMLHGRE-LLASAPTGSGKTLAFSIPILMQLKQP 122
Query: 935 -NSEGRCVYITPMRLWQEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLG-----KGNI 988
N R + I+P R Q++ + K + ++ ++ + + K G K +I
Sbjct: 123 ANKGFRALIISPTRELASQIHRELI-KISEGTGFRIHMI-HKAAVAAKKFGPKSSKKFDI 180
Query: 989 IISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLI--GGENGPVLEVICSRMRYISSQIE 1046
+++TP + L ++ ++ ++ VVDE + G+ G ++ + S ++
Sbjct: 181 LVTTPNRLIYLLKQDPPGIDLASVEWLVVDESDKLFEDGKTGFRDQLASIFLACTSHKVR 240
Query: 1047 RPIRIVALSSSLSNAKDVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQT-RLLS 1105
R + S + A DV W + + + R +E Q ++T +LL+
Sbjct: 241 RAM------FSATFAYDVEQWCKLNLDNVISVSIGARNSAVETVEQELLFVGSETGKLLA 294
Query: 1106 MAKPVFHAITKHSPKKPVIVFVPSRKQTR 1134
M + + K PV+VFV S ++ +
Sbjct: 295 MRE-----LVKKGFNPPVLVFVQSIERAK 318
Score = 31.6 bits (70), Expect = 6.9
Identities = 39/159 (24%), Positives = 66/159 (41%), Gaps = 28/159 (17%)
Query: 41 GFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDF 100
GF+ IQ + L E LL APTG+GKT + +L ++ + N F
Sbjct: 76 GFQMPTPIQMQAIPVMLHGRE-LLASAPTGSGKTLAFSIPILMQLKQPAN-------KGF 127
Query: 101 KIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTG--DHQLCKEEISATQ---------- 148
+ + I+P R L ++ I ++E TG H + K ++A +
Sbjct: 128 RALIISPTRELASQIHREL--------IKISEGTGFRIHMIHKAAVAAKKFGPKSSKKFD 179
Query: 149 IIVCTPEKWDIITRKGGERTYTQLVRLIVLDEIHLLHDD 187
I+V TP + + ++ V +V+DE L +D
Sbjct: 180 ILVTTPNRLIYLLKQDPPGIDLASVEWLVVDESDKLFED 218
>gi|38569505 ATP-dependent RNA helicase ROK1 isoform a [Homo sapiens]
Length = 599
Score = 41.6 bits (96), Expect = 0.007
Identities = 58/269 (21%), Positives = 114/269 (42%), Gaps = 24/269 (8%)
Query: 876 LRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQ- 934
+ + +++ F PIQ Q + + + + APTGSGKT+ IL L Q
Sbjct: 172 INSRLLQNILDAGFQMPTPIQMQAIPVMLHGRE-LLASAPTGSGKTLAFSIPILMQLKQP 230
Query: 935 -NSEGRCVYITPMRLWQEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLG-----KGNI 988
N R + I+P R Q++ + K + ++ ++ + + K G K +I
Sbjct: 231 ANKGFRALIISPTRELASQIHRELI-KISEGTGFRIHMI-HKAAVAAKKFGPKSSKKFDI 288
Query: 989 IISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLI--GGENGPVLEVICSRMRYISSQIE 1046
+++TP + L ++ ++ ++ VVDE + G+ G ++ + S ++
Sbjct: 289 LVTTPNRLIYLLKQDPPGIDLASVEWLVVDESDKLFEDGKTGFRDQLASIFLACTSHKVR 348
Query: 1047 RPIRIVALSSSLSNAKDVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQT-RLLS 1105
R + S + A DV W + + + R +E Q ++T +LL+
Sbjct: 349 RAM------FSATFAYDVEQWCKLNLDNVISVSIGARNSAVETVEQELLFVGSETGKLLA 402
Query: 1106 MAKPVFHAITKHSPKKPVIVFVPSRKQTR 1134
M + + K PV+VFV S ++ +
Sbjct: 403 MRE-----LVKKGFNPPVLVFVQSIERAK 426
Score = 31.6 bits (70), Expect = 6.9
Identities = 39/159 (24%), Positives = 66/159 (41%), Gaps = 28/159 (17%)
Query: 41 GFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDF 100
GF+ IQ + L E LL APTG+GKT + +L ++ + N F
Sbjct: 184 GFQMPTPIQMQAIPVMLHGRE-LLASAPTGSGKTLAFSIPILMQLKQPAN-------KGF 235
Query: 101 KIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTG--DHQLCKEEISATQ---------- 148
+ + I+P R L ++ I ++E TG H + K ++A +
Sbjct: 236 RALIISPTRELASQIHREL--------IKISEGTGFRIHMIHKAAVAAKKFGPKSSKKFD 287
Query: 149 IIVCTPEKWDIITRKGGERTYTQLVRLIVLDEIHLLHDD 187
I+V TP + + ++ V +V+DE L +D
Sbjct: 288 ILVTTPNRLIYLLKQDPPGIDLASVEWLVVDESDKLFED 326
>gi|41327779 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 [Homo sapiens]
Length = 600
Score = 40.4 bits (93), Expect = 0.015
Identities = 45/166 (27%), Positives = 77/166 (46%), Gaps = 18/166 (10%)
Query: 869 QPLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAI 928
+ LPV L +L + FP+ P+Q+ + D V A TGSGKT+ I
Sbjct: 10 ESLPVP-LHPQVLGALRELGFPYMTPVQSATIPLFMRNKD-VAAEAVTGSGKTLAFVIPI 67
Query: 929 LRML------LQNSEGRCVYITPMRLWQEQV--YMDWYEKFQDRLNKKVVL---LTGETS 977
L +L L+ S+ + ITP R Q+ + + K ++ + + GE
Sbjct: 68 LEILLRREEKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDV 127
Query: 978 TDLKLLGKGNIIISTPEKWDILSRRWKQRKN----VQNINLFVVDE 1019
K G GNII++TP + + + RR + + V+++++ V+DE
Sbjct: 128 ERFKQQG-GNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDE 172
>gi|149408122 RNA helicase LGP2 [Homo sapiens]
Length = 678
Score = 40.0 bits (92), Expect = 0.019
Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 19/180 (10%)
Query: 45 LNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIY 104
L Q ++ ALE +N+++ PTGAGKT A R + VD K++
Sbjct: 3 LRSYQWEVIMPALE-GKNIIIWLPTGAGKTRAAAYVAKRHLE---------TVDGAKVVV 52
Query: 105 IAPMRSLVQEMVGSFGKRLATYGITVAELTGD---HQLCKEEISATQIIVCTPEKWDIIT 161
+ LV + F +R+ TV L+GD +++CT E +
Sbjct: 53 LVNRVHLVTQHGEEF-RRMLDGRWTVTTLSGDMGPRAGFGHLARCHDLLICTAELLQMAL 111
Query: 162 RKGGERTYTQLV--RLIVLDEIHLLHDDRGPVLEALVARAIR-NIEMTQEDVRLIGLSAT 218
E + +L LIV+DE H H D V ++++ + ++ Q +++GL+A+
Sbjct: 112 TSPEEEEHVELTVFSLIVVDECHHTHKD--TVYNVIMSQYLELKLQRAQPLPQVLGLTAS 169
>gi|27881482 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I
[Homo sapiens]
Length = 925
Score = 38.9 bits (89), Expect = 0.043
Identities = 29/125 (23%), Positives = 55/125 (44%), Gaps = 10/125 (8%)
Query: 61 ENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFG 120
+N ++CAPTG GKT V+L+ + K K+++ A + ++ F
Sbjct: 258 KNTIICAPTGCGKTFVSLLICEHHLKKF------PQGQKGKVVFFANQIPVYEQQKSVFS 311
Query: 121 KRLATYGITVAELTG---DHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIV 177
K +G V ++G ++ ++ + II+ TP+ + K G + L++
Sbjct: 312 KYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQIL-VNNLKKGTIPSLSIFTLMI 370
Query: 178 LDEIH 182
DE H
Sbjct: 371 FDECH 375
Score = 34.7 bits (78), Expect = 0.81
Identities = 40/157 (25%), Positives = 69/157 (43%), Gaps = 40/157 (25%)
Query: 909 NVFVGAPTGSGKT-----ICAEFAILRMLLQNSEGRCVYIT---PMRLWQEQVYMDWYEK 960
N + APTG GKT IC L+ Q +G+ V+ P+ Q+ V+ ++E
Sbjct: 259 NTIICAPTGCGKTFVSLLICEHH--LKKFPQGQKGKVVFFANQIPVYEQQKSVFSKYFE- 315
Query: 961 FQDRLNKKVVLLTGETSTDL---KLLGKGNIIISTPEKWDILSRRWKQR--KNVQNINLF 1015
R +V ++G T+ ++ +++ +III TP+ IL K+ ++ L
Sbjct: 316 ---RHGYRVTGISGATAENVPVEQIVENNDIIILTPQ---ILVNNLKKGTIPSLSIFTLM 369
Query: 1016 VVDEVH------------------LIGGENGPVLEVI 1034
+ DE H +GG +GP+ +VI
Sbjct: 370 IFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVI 406
>gi|209862869 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 3
[Homo sapiens]
Length = 724
Score = 38.9 bits (89), Expect = 0.043
Identities = 70/288 (24%), Positives = 120/288 (41%), Gaps = 55/288 (19%)
Query: 62 NLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFK------IIYIAPMRSLVQEM 115
+L+ CA TG+GKT L+ +L H+ DG I FK I +AP R LV ++
Sbjct: 327 DLMACAQTGSGKTAAFLLPIL----AHMMHDG-ITASRFKELQEPECIIVAPTRELVNQI 381
Query: 116 VGSFGKRLATYGITVAELTGDHQL---CKEEISATQIIVCTPEK-WDIITRKGGERTYTQ 171
K + + G QL ++ + I+ TP + DII G E+ +
Sbjct: 382 YLEARKFSFGTCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDII---GKEKIGLK 438
Query: 172 LVRLIVLDEI-HLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLR 230
++ +VLDE +L GP ++ L++ ++E + + SAT P E++ L
Sbjct: 439 QIKYLVLDEADRMLDMGFGPEMKKLISCPGM---PSKEQRQTLMFSATFP--EEIQR-LA 492
Query: 231 VDPAKGLFYF------DNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQ 284
+ K + F + R V VG +F ++V +I+ + G +
Sbjct: 493 AEFLKSNYLFVAVGQVGGACRDVQQTVLQVG--------QFSKREKLV--EILRNIGDER 542
Query: 285 VLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQ 332
+VFV ++K+ D + FL + ST + + EQ
Sbjct: 543 TMVFVETKKKA--------------DFIATFLCQEKISTTSIHGDREQ 576
>gi|13518015 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 1
[Homo sapiens]
Length = 724
Score = 38.9 bits (89), Expect = 0.043
Identities = 70/288 (24%), Positives = 120/288 (41%), Gaps = 55/288 (19%)
Query: 62 NLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFK------IIYIAPMRSLVQEM 115
+L+ CA TG+GKT L+ +L H+ DG I FK I +AP R LV ++
Sbjct: 327 DLMACAQTGSGKTAAFLLPIL----AHMMHDG-ITASRFKELQEPECIIVAPTRELVNQI 381
Query: 116 VGSFGKRLATYGITVAELTGDHQL---CKEEISATQIIVCTPEK-WDIITRKGGERTYTQ 171
K + + G QL ++ + I+ TP + DII G E+ +
Sbjct: 382 YLEARKFSFGTCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDII---GKEKIGLK 438
Query: 172 LVRLIVLDEI-HLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLR 230
++ +VLDE +L GP ++ L++ ++E + + SAT P E++ L
Sbjct: 439 QIKYLVLDEADRMLDMGFGPEMKKLISCPGM---PSKEQRQTLMFSATFP--EEIQR-LA 492
Query: 231 VDPAKGLFYF------DNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQ 284
+ K + F + R V VG +F ++V +I+ + G +
Sbjct: 493 AEFLKSNYLFVAVGQVGGACRDVQQTVLQVG--------QFSKREKLV--EILRNIGDER 542
Query: 285 VLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQ 332
+VFV ++K+ D + FL + ST + + EQ
Sbjct: 543 TMVFVETKKKA--------------DFIATFLCQEKISTTSIHGDREQ 576
>gi|216548263 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 2
[Homo sapiens]
Length = 690
Score = 38.9 bits (89), Expect = 0.043
Identities = 70/288 (24%), Positives = 120/288 (41%), Gaps = 55/288 (19%)
Query: 62 NLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFK------IIYIAPMRSLVQEM 115
+L+ CA TG+GKT L+ +L H+ DG I FK I +AP R LV ++
Sbjct: 293 DLMACAQTGSGKTAAFLLPIL----AHMMHDG-ITASRFKELQEPECIIVAPTRELVNQI 347
Query: 116 VGSFGKRLATYGITVAELTGDHQL---CKEEISATQIIVCTPEK-WDIITRKGGERTYTQ 171
K + + G QL ++ + I+ TP + DII G E+ +
Sbjct: 348 YLEARKFSFGTCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDII---GKEKIGLK 404
Query: 172 LVRLIVLDEI-HLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLR 230
++ +VLDE +L GP ++ L++ ++E + + SAT P E++ L
Sbjct: 405 QIKYLVLDEADRMLDMGFGPEMKKLISCPGM---PSKEQRQTLMFSATFP--EEIQR-LA 458
Query: 231 VDPAKGLFYF------DNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQ 284
+ K + F + R V VG +F ++V +I+ + G +
Sbjct: 459 AEFLKSNYLFVAVGQVGGACRDVQQTVLQVG--------QFSKREKLV--EILRNIGDER 508
Query: 285 VLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQ 332
+VFV ++K+ D + FL + ST + + EQ
Sbjct: 509 TMVFVETKKKA--------------DFIATFLCQEKISTTSIHGDREQ 542
>gi|4557365 Bloom syndrome protein [Homo sapiens]
Length = 1417
Score = 38.1 bits (87), Expect = 0.073
Identities = 62/229 (27%), Positives = 96/229 (41%), Gaps = 40/229 (17%)
Query: 823 FEPLPPQYFIRVVSDRWLSCETQ-LPVSF--RHLILPEKYPPPTELLDLQPLPVSALRNS 879
++P+ I+ VS+R S +T LPVS +++ E T+ Q L L++
Sbjct: 584 YQPIKEGRPIKSVSERLSSAKTDCLPVSSTAQNINFSESIQNYTDK-SAQNLASRNLKHE 642
Query: 880 AFESL-----------YQDKFPF--FNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEF 926
F+SL + KF F Q + N +D F+ PTG GK++C +
Sbjct: 643 RFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGED-CFILMPTGGGKSLCYQL 701
Query: 927 AILRMLLQNSEGRCVYITPMRLWQEQVYMDWYEKFQDRLNKKVVLLTGE------TSTDL 980
S G V I+P+R + +D +K L+ LTG+ T+ L
Sbjct: 702 PAC-----VSPGVTVVISPLR----SLIVDQVQKLTS-LDIPATYLTGDKTDSEATNIYL 751
Query: 981 KLLGKGNII---ISTPEKWDILSRRWKQRKNVQNINL---FVVDEVHLI 1023
+L K II TPEK +R +N+ L FV+DE H +
Sbjct: 752 QLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCV 800
>gi|110735439 Werner syndrome protein [Homo sapiens]
Length = 1432
Score = 37.7 bits (86), Expect = 0.096
Identities = 84/344 (24%), Positives = 139/344 (40%), Gaps = 75/344 (21%)
Query: 892 FNPIQTQVFNTVYNSD-DNVFVGAPTGSGKTICAEFAILRMLLQNSEGRC-VYITPM-RL 948
F P+Q +V ++V DNV V A TG GK++C ++ + + G+ + I+P+ L
Sbjct: 549 FKPVQWKVIHSVLEERRDNVAVMA-TGYGKSLCFQYPPVYV------GKIGLVISPLISL 601
Query: 949 WQEQVYMDWYEKFQDRLNKKVVLLTGETS-----TDLKLLGKGNIIISTPEKWDILSRRW 1003
++QV Q +++ G TD+K LGK I+ TPE
Sbjct: 602 MEDQV-------LQLKMSNIPACFLGSAQSENVLTDIK-LGKYRIVYVTPEYCSGNMGLL 653
Query: 1004 KQRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNA-- 1061
+Q + I L VDE H I E G ++ + + + + IVAL+++ S++
Sbjct: 654 QQLEADIGITLIAVDEAHCI-SEWGHDFRDSFRKLGSLKTALPM-VPIVALTATASSSIR 711
Query: 1062 KDVAHWLGC---SATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVFHAITKH- 1117
+D+ L T T PN+ LE+ + NI L +P + H
Sbjct: 712 EDIVRCLNLRNPQITCTGFDRPNLY---LEVRRKTGNI-------LQDLQPFLVKTSSHW 761
Query: 1118 SPKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETL 1177
+ P I++ PSRK T+ ++ R+ L C
Sbjct: 762 EFEGPTIIYCPSRKMTQQVTGEL---------RKLNLSC--------------------- 791
Query: 1178 LNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVA 1221
G H G+S R+ + F IQ V+A+ + G+N A
Sbjct: 792 ----GTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKA 831
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,872,504
Number of Sequences: 37866
Number of extensions: 2769908
Number of successful extensions: 6607
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 6416
Number of HSP's gapped (non-prelim): 114
length of query: 1700
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1584
effective length of database: 13,855,062
effective search space: 21946418208
effective search space used: 21946418208
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.