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Search of human proteins with 169217489
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169217489 PREDICTED: similar to phosphodiesterase 4D
interacting protein [Homo sapiens]
(211 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169217489 PREDICTED: similar to phosphodiesterase 4D interact... 407 e-114
gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [... 380 e-106
gi|50658071 phosphodiesterase 4D interacting protein isoform 5 [... 380 e-106
gi|157311604 phosphodiesterase 4D interacting protein isoform 1 ... 380 e-106
gi|71061468 centromere protein E [Homo sapiens] 65 4e-11
gi|55770834 centromere protein F [Homo sapiens] 64 1e-10
gi|21735548 centrosomal protein 2 [Homo sapiens] 57 1e-08
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 57 1e-08
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 56 3e-08
gi|38044112 restin isoform b [Homo sapiens] 55 3e-08
gi|4506751 restin isoform a [Homo sapiens] 55 3e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 55 3e-08
gi|38348729 hypothetical protein LOC203238 [Homo sapiens] 55 3e-08
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 55 6e-08
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 55 6e-08
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 54 7e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 54 7e-08
gi|16262452 cingulin [Homo sapiens] 54 7e-08
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 54 7e-08
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 54 7e-08
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 54 7e-08
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 54 7e-08
gi|167614504 laminin, beta 1 precursor [Homo sapiens] 54 1e-07
gi|70166430 GRINL1A combined protein isoform 2 [Homo sapiens] 54 1e-07
gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens] 54 1e-07
gi|70166580 GRINL1A upstream protein isoform 7 [Homo sapiens] 54 1e-07
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 54 1e-07
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 53 2e-07
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 53 2e-07
gi|13540600 nudE nuclear distribution gene E homolog (A. nidulan... 53 2e-07
>gi|169217489 PREDICTED: similar to phosphodiesterase 4D interacting
protein [Homo sapiens]
Length = 211
Score = 407 bits (1046), Expect = e-114
Identities = 211/211 (100%), Positives = 211/211 (100%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL
Sbjct: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER
Sbjct: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ 180
DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ
Sbjct: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ 180
Query: 181 ESIIQQLQTSLHDRNKEVEARLQLTLRQLVQ 211
ESIIQQLQTSLHDRNKEVEARLQLTLRQLVQ
Sbjct: 181 ESIIQQLQTSLHDRNKEVEARLQLTLRQLVQ 211
>gi|50658069 phosphodiesterase 4D interacting protein isoform 2
[Homo sapiens]
Length = 969
Score = 380 bits (975), Expect = e-106
Identities = 195/198 (98%), Positives = 197/198 (99%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
+ELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL
Sbjct: 398 QELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 457
Query: 62 QYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 121
QYRDNSDKTLEANEMLLEKLRQRI DKAVALERAIDEKFSALEEKEKELRQLRLAVRERD
Sbjct: 458 QYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 517
Query: 122 HDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 181
HDLERLRDVLSSNEATMQ+MESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE
Sbjct: 518 HDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 577
Query: 182 SIIQQLQTSLHDRNKEVE 199
SIIQQLQTSLHDRNKEVE
Sbjct: 578 SIIQQLQTSLHDRNKEVE 595
Score = 48.5 bits (114), Expect = 4e-06
Identities = 49/224 (21%), Positives = 99/224 (44%), Gaps = 19/224 (8%)
Query: 1 MEELRKALQQ-------LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQL 53
+ EL++ +QQ LQE+L S +L+ + + Q+ IQ+L +L +E+
Sbjct: 241 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESS----QKQDGTIQNLKETLKSRERE 296
Query: 54 LQEFRELLQYRDNSDKTLEANEML----LEKLRQRIRDKAVALERAIDEKFSALEEKEKE 109
+E ++++ +D + EML L +L + A+ + SAL + E
Sbjct: 297 TEELYQVIE--GQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLE 354
Query: 110 LRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEM 169
+++L+ VR+++ L + + EA E A ++L Q LQ +
Sbjct: 355 IQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNK 414
Query: 170 ETKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQL--TLRQLVQ 211
+ W+ E+ + I+ + ++ N + + QL R+L+Q
Sbjct: 415 SQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 458
Score = 45.8 bits (107), Expect = 3e-05
Identities = 61/254 (24%), Positives = 103/254 (40%), Gaps = 52/254 (20%)
Query: 3 ELRKALQQLQEELQNKSQQL-RAW----------EAEKYNEIRTQEQNIQHLNHSLSHKE 51
EL+ ++ L+ ELQ+K Q L + W EAE + ++Q +H+ L +K
Sbjct: 50 ELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKI 109
Query: 52 QLLQEFRELLQYRDNSDKTL-----EANEMLLEKLR----------------QRIRDKAV 90
QLLQE L + L E N L EKL+ + +
Sbjct: 110 QLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALA 169
Query: 91 ALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER--------------LRDVLSSNEA 136
++ I+E +L +E+ + QL ++ H LE + L+S+E
Sbjct: 170 QRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHET 229
Query: 137 TM---QTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ---KEQESIIQQLQTS 190
T+ +S L +++Q T + LQ EM + Q ++Q+ IQ L+ +
Sbjct: 230 TITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKET 289
Query: 191 LHDRNKEVEARLQL 204
L R +E E Q+
Sbjct: 290 LKSRERETEELYQV 303
>gi|50658071 phosphodiesterase 4D interacting protein isoform 5
[Homo sapiens]
Length = 1132
Score = 380 bits (975), Expect = e-106
Identities = 195/198 (98%), Positives = 197/198 (99%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
+ELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL
Sbjct: 561 QELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 620
Query: 62 QYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 121
QYRDNSDKTLEANEMLLEKLRQRI DKAVALERAIDEKFSALEEKEKELRQLRLAVRERD
Sbjct: 621 QYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 680
Query: 122 HDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 181
HDLERLRDVLSSNEATMQ+MESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE
Sbjct: 681 HDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 740
Query: 182 SIIQQLQTSLHDRNKEVE 199
SIIQQLQTSLHDRNKEVE
Sbjct: 741 SIIQQLQTSLHDRNKEVE 758
Score = 48.5 bits (114), Expect = 4e-06
Identities = 49/224 (21%), Positives = 99/224 (44%), Gaps = 19/224 (8%)
Query: 1 MEELRKALQQ-------LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQL 53
+ EL++ +QQ LQE+L S +L+ + + Q+ IQ+L +L +E+
Sbjct: 404 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESS----QKQDGTIQNLKETLKSRERE 459
Query: 54 LQEFRELLQYRDNSDKTLEANEML----LEKLRQRIRDKAVALERAIDEKFSALEEKEKE 109
+E ++++ +D + EML L +L + A+ + SAL + E
Sbjct: 460 TEELYQVIE--GQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLE 517
Query: 110 LRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEM 169
+++L+ VR+++ L + + EA E A ++L Q LQ +
Sbjct: 518 IQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNK 577
Query: 170 ETKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQL--TLRQLVQ 211
+ W+ E+ + I+ + ++ N + + QL R+L+Q
Sbjct: 578 SQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 621
>gi|157311604 phosphodiesterase 4D interacting protein isoform 1
[Homo sapiens]
Length = 2346
Score = 380 bits (975), Expect = e-106
Identities = 195/198 (98%), Positives = 197/198 (99%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
+ELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL
Sbjct: 398 QELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 457
Query: 62 QYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 121
QYRDNSDKTLEANEMLLEKLRQRI DKAVALERAIDEKFSALEEKEKELRQLRLAVRERD
Sbjct: 458 QYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 517
Query: 122 HDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 181
HDLERLRDVLSSNEATMQ+MESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE
Sbjct: 518 HDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 577
Query: 182 SIIQQLQTSLHDRNKEVE 199
SIIQQLQTSLHDRNKEVE
Sbjct: 578 SIIQQLQTSLHDRNKEVE 595
Score = 48.5 bits (114), Expect = 4e-06
Identities = 49/224 (21%), Positives = 99/224 (44%), Gaps = 19/224 (8%)
Query: 1 MEELRKALQQ-------LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQL 53
+ EL++ +QQ LQE+L S +L+ + + Q+ IQ+L +L +E+
Sbjct: 241 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESS----QKQDGTIQNLKETLKSRERE 296
Query: 54 LQEFRELLQYRDNSDKTLEANEML----LEKLRQRIRDKAVALERAIDEKFSALEEKEKE 109
+E ++++ +D + EML L +L + A+ + SAL + E
Sbjct: 297 TEELYQVIE--GQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLE 354
Query: 110 LRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEM 169
+++L+ VR+++ L + + EA E A ++L Q LQ +
Sbjct: 355 IQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNK 414
Query: 170 ETKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQL--TLRQLVQ 211
+ W+ E+ + I+ + ++ N + + QL R+L+Q
Sbjct: 415 SQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 458
Score = 45.8 bits (107), Expect = 3e-05
Identities = 61/254 (24%), Positives = 103/254 (40%), Gaps = 52/254 (20%)
Query: 3 ELRKALQQLQEELQNKSQQL-RAW----------EAEKYNEIRTQEQNIQHLNHSLSHKE 51
EL+ ++ L+ ELQ+K Q L + W EAE + ++Q +H+ L +K
Sbjct: 50 ELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKI 109
Query: 52 QLLQEFRELLQYRDNSDKTL-----EANEMLLEKLR----------------QRIRDKAV 90
QLLQE L + L E N L EKL+ + +
Sbjct: 110 QLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALA 169
Query: 91 ALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER--------------LRDVLSSNEA 136
++ I+E +L +E+ + QL ++ H LE + L+S+E
Sbjct: 170 QRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHET 229
Query: 137 TM---QTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ---KEQESIIQQLQTS 190
T+ +S L +++Q T + LQ EM + Q ++Q+ IQ L+ +
Sbjct: 230 TITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKET 289
Query: 191 LHDRNKEVEARLQL 204
L R +E E Q+
Sbjct: 290 LKSRERETEELYQV 303
Score = 36.2 bits (82), Expect = 0.021
Identities = 39/185 (21%), Positives = 80/185 (43%), Gaps = 31/185 (16%)
Query: 39 NIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKA--------- 89
++ LN + + L + E+ R ++++ N+ L E+L R+ A
Sbjct: 1830 SVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNF 1889
Query: 90 -----VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESL 144
++ + +E E+ + QL RE + E LR+ L S+ + +Q +E
Sbjct: 1890 YSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKE 1949
Query: 145 LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESI-IQQLQTSLHDRNKEVEARLQ 203
L + +E +QL L+ L+E K+QE + ++ + SL + + ++ +L
Sbjct: 1950 LEHQKVERQQL------LEDLRE----------KQQEVLHFREERLSLQENDSRLQHKLV 1993
Query: 204 LTLRQ 208
L +Q
Sbjct: 1994 LLQQQ 1998
Score = 35.0 bits (79), Expect = 0.047
Identities = 43/202 (21%), Positives = 76/202 (37%), Gaps = 31/202 (15%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
E LR+AL + LQ ++L + E+ Q L L K+Q + FRE
Sbjct: 1930 ESLREALLSSRSHLQELEKELEHQKVER-----------QQLLEDLREKQQEVLHFRE-- 1976
Query: 62 QYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRE-- 119
+ L++ R++ K V L++ +EK E + EL+
Sbjct: 1977 ------------ERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSK 2024
Query: 120 ---RDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRW 176
+ + L+ + S++ + E LE C LQ L++++E+ +
Sbjct: 2025 KGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQ-LQQQLESGAGKA 2083
Query: 177 QKEQESIIQQLQTSLHDRNKEV 198
SI Q S NK++
Sbjct: 2084 SLSPSSINQNFPASTDPGNKQL 2105
Score = 30.8 bits (68), Expect = 0.88
Identities = 25/88 (28%), Positives = 43/88 (48%), Gaps = 16/88 (18%)
Query: 1 MEELRKAL-------QQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQH----LNHSLSH 49
++EL K L QQL E+L+ K Q++ + E+ + ++ + +QH L
Sbjct: 1943 LQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLS-LQENDSRLQHKLVLLQQQCEE 2001
Query: 50 KEQLLQEFRELLQYRD----NSDKTLEA 73
K+QL + + LQ + NS K L+A
Sbjct: 2002 KQQLFESLQSELQIYEALYGNSKKGLKA 2029
Score = 28.5 bits (62), Expect = 4.4
Identities = 29/125 (23%), Positives = 49/125 (39%), Gaps = 27/125 (21%)
Query: 72 EANEMLLEKLRQRIRDKAVALERAIDEKFSAL---------------------EEKEKEL 110
+ E+L K +R AL A++E S L E E+EL
Sbjct: 2220 QGTEVLGSKGIHELRSSTSALHHALEESASLLTMFWRAALPSTHIPVLPGKVGESTEREL 2279
Query: 111 RQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEME 170
+LR V +++ L+ + L + ++ME + V QL+ T L+ + +E
Sbjct: 2280 LELRTKVSKQERLLQSTTEHLKNANQQKESMEQFI------VSQLTRTHDVLKKARTNLE 2333
Query: 171 TKFSR 175
K R
Sbjct: 2334 VKSLR 2338
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 65.1 bits (157), Expect = 4e-11
Identities = 59/238 (24%), Positives = 115/238 (48%), Gaps = 38/238 (15%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEK---YNEIRTQEQNIQHLNHSLSHK------- 50
++ L +++L++E+Q+KS++L +EK ++E+ +E +Q L +
Sbjct: 749 LKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATT 808
Query: 51 -------EQLLQEFREL-LQYRDNSDKTLEANEML------LEKLRQRIRDKAVALERAI 96
+Q Q F+ L + + LE NE + L K Q+ AL+ +
Sbjct: 809 QSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTEL 868
Query: 97 DEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLS 156
K L+EK +E V+ER +++E+L++ L + ++T+QT+E R K L E+L
Sbjct: 869 SYKTQELQEKTRE-------VQERLNEMEQLKEQLENRDSTLQTVE---REKTLITEKLQ 918
Query: 157 TTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHD---RNKEVEARLQLTLRQLVQ 211
T + ++ L +E + + Q+ + QL++ +HD N + + +L+ L L Q
Sbjct: 919 QTLEEVKTLTQEKD-DLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQ 975
Score = 58.2 bits (139), Expect = 5e-09
Identities = 51/211 (24%), Positives = 105/211 (49%), Gaps = 21/211 (9%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ--EFRE 59
EELR A L+E+ Q +LR +EK +++ ++++++ N L K Q L+ E +
Sbjct: 1774 EELRIAHMHLKEQ-QETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQL 1832
Query: 60 LLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRE 119
+ +D ++ + +EM E+L+++I+D+++ L + E + ++ + L +++ ++E
Sbjct: 1833 ITLKKDVNETQKKVSEM--EQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKE 1890
Query: 120 RDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKE 179
RD+ L R+ + L ++ +A+ LE++Q T + L KE ET +K
Sbjct: 1891 RDN-LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLS--KEHKETVDKLREKI 1947
Query: 180 QESIIQ-------------QLQTSLHDRNKE 197
E IQ +LQ + + K+
Sbjct: 1948 SEKTIQISDIQKDLDKSKDELQKKIQELQKK 1978
Score = 51.6 bits (122), Expect = 5e-07
Identities = 57/257 (22%), Positives = 108/257 (42%), Gaps = 59/257 (22%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQE----- 56
EEL+ L+E Q +LR +EK NEI +++++H N +L ++ +QE
Sbjct: 1721 EELKIVHMHLKEH-QETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIA 1779
Query: 57 FRELLQYRDNSDK-------------------------------TLEANEMLL------- 78
L + ++ DK L+ANE L
Sbjct: 1780 HMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDV 1839
Query: 79 ----------EKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLR 128
E+L+++I+D+++ L + E + ++ + L +++ ++ERD +L R+
Sbjct: 1840 NETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERD-NLRRVE 1898
Query: 129 DVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQ--Q 186
+ L ++ +A+ LE++Q T + L KE ET +K E IQ
Sbjct: 1899 ETLKLERDQLKESLQETKARDLEIQQELKTARMLS--KEHKETVDKLREKISEKTIQISD 1956
Query: 187 LQTSLHDRNKEVEARLQ 203
+Q L E++ ++Q
Sbjct: 1957 IQKDLDKSKDELQKKIQ 1973
Score = 50.8 bits (120), Expect = 8e-07
Identities = 52/214 (24%), Positives = 109/214 (50%), Gaps = 22/214 (10%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
EEL+ A L+E+ + +LR +EK EI T ++ ++ +N L +K Q + E E
Sbjct: 1477 EELKVAHCCLKEQ-EETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQF 1535
Query: 62 QYRDNSDKTLEANEMLLEKLRQRIRDKAV-ALERAIDEKFSALEEKEKELRQLRLAVRER 120
+ S+ + NE+ K ++ +D A+ ++E + E + L+E ++E +++ ++E+
Sbjct: 1536 NIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEE---IQIMIKEK 1592
Query: 121 DHDLERLRDVL-----SSNEATMQTMESLLRAKGLEVEQLSTTCQN--------LQWLKE 167
+ +++R+++ L E T + + + ++ E + L T N ++ LKE
Sbjct: 1593 E-EMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKE 1651
Query: 168 EMET-KFSRWQKEQESIIQQLQTSLHDRNKEVEA 200
+ ET K + E E+I +L LH+ +E+ +
Sbjct: 1652 QFETQKLNLENIETENI--RLTQILHENLEEMRS 1683
Score = 44.7 bits (104), Expect = 6e-05
Identities = 43/203 (21%), Positives = 94/203 (46%), Gaps = 11/203 (5%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQL----LQEF 57
E K Q L+ N++Q+ + TQ+ N++++ Q+ L+E
Sbjct: 1622 ESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEM 1681
Query: 58 RELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVA-LERAIDEKF--SALEEKEKELRQLR 114
R + + RD+ E ++ ++L++ +R+ LE+ + K L+E ++ + +LR
Sbjct: 1682 RSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLR 1741
Query: 115 LAVRERDHDLERL-RDVLSSNEATMQ---TMESLLRAKGLEVEQLSTTCQNLQWLKEEME 170
V E+ +++ + +D+ SN+A ++ LR + +++ T L+ + E
Sbjct: 1742 GIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKT 1801
Query: 171 TKFSRWQKEQESIIQQLQTSLHD 193
K S QK+ E+ +LQ + +
Sbjct: 1802 DKLSNMQKDLENSNAKLQEKIQE 1824
Score = 43.1 bits (100), Expect = 2e-04
Identities = 48/225 (21%), Positives = 96/225 (42%), Gaps = 25/225 (11%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAE------KYNEIRTQEQNIQHLNHSLSHKEQLL 54
+ E+ + L++ ++LQ K QQL + E K NEI + +++ +L H E
Sbjct: 1122 LAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETER 1181
Query: 55 QEFRELLQYRDNSDKTLEANEMLLEKLRQRI---RD---------KAVALERAIDEKFS- 101
E + L K++ +L++L++ RD +A L+ + K +
Sbjct: 1182 LELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAH 1241
Query: 102 -ALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGL-----EVEQL 155
L+E ++ + +LR +V E+ + +D+ S+ + + L + L EV +
Sbjct: 1242 IHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSET 1301
Query: 156 STTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEA 200
T L+ L E+ TK S E +L + +E+++
Sbjct: 1302 QETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKS 1346
Score = 43.1 bits (100), Expect = 2e-04
Identities = 58/260 (22%), Positives = 107/260 (41%), Gaps = 55/260 (21%)
Query: 1 MEELRKALQQLQE--ELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQE-F 57
+ E ++ L ++E E Q +L + + T I+ L+ K Q QE
Sbjct: 1285 LHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEI 1344
Query: 58 RELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKE-------- 109
+ L + RDN EA E+ ++L++ IR+ ++ + ++ +L KEK+
Sbjct: 1345 KSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVS 1404
Query: 110 ------------LR-----------------QLRLAVRERDHDLERLRDVLSSNEATMQT 140
LR +++ +E+D DL+RL++VL S ++
Sbjct: 1405 EMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKD-DLQRLQEVLQSESDQLKE 1463
Query: 141 MESLLRAKGLEVE-----------QLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQT 189
+ AK LE E + T L+ E ET+ S QK+ E+I +LQ
Sbjct: 1464 NIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQN 1523
Query: 190 SLHDRNKEVEARLQLTLRQL 209
+ + ++ E Q ++Q+
Sbjct: 1524 KIQEIYEKEE---QFNIKQI 1540
Score = 40.4 bits (93), Expect = 0.001
Identities = 48/212 (22%), Positives = 101/212 (47%), Gaps = 33/212 (15%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQ-NIQHLNHSLSHKEQLLQEFRE 59
+ +++K L + ++ELQ K Q+L+ E + +R +E N+ H ++ EQL ++F
Sbjct: 1954 ISDIQKDLDKSKDELQKKIQELQKKELQL---LRVKEDVNMSH--KKINEMEQLKKQF-- 2006
Query: 60 LLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVR- 118
EA + ++ +R L +++E +E++ ELR+++ +++
Sbjct: 2007 ------------EAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERD-ELRRIKESLKM 2053
Query: 119 ERDHDLERLRDVLSSNEATMQTM-ESLLRAKGLE--VEQLSTTCQNLQWLKEEMETKFSR 175
ERD + LR++++ + Q E L + G + E L C + +E+ ++S
Sbjct: 2054 ERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRI----KELLKRYS- 2108
Query: 176 WQKEQESIIQQLQTSLHDRNKEVEARLQLTLR 207
E + + L D KE+E + +L++R
Sbjct: 2109 ---EMDDHYECLNRLSLDLEKEIEFQKELSMR 2137
Score = 38.5 bits (88), Expect = 0.004
Identities = 51/224 (22%), Positives = 97/224 (43%), Gaps = 53/224 (23%)
Query: 4 LRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQY 63
L+ L +ELQ K+++++ E+ NE+ ++ +E L+
Sbjct: 864 LKTELSYKTQELQEKTREVQ----ERLNEM---------------------EQLKEQLEN 898
Query: 64 RDNSDKTLEANEMLL-EKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVR-ERD 121
RD++ +T+E + L+ EKL+Q + E+ L +++ +L+QL+ +++ ERD
Sbjct: 899 RDSTLQTVEREKTLITEKLQQTL------------EEVKTLTQEKDDLKQLQESLQIERD 946
Query: 122 ------HDL--------ERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKE 167
HD E+LR+ L S + +T+ +L EV + +N K+
Sbjct: 947 QLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKD 1006
Query: 168 EMETKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLRQLVQ 211
E + K K+Q+ + QT D Q + L+Q
Sbjct: 1007 EFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQ 1050
Score = 38.5 bits (88), Expect = 0.004
Identities = 48/233 (20%), Positives = 105/233 (45%), Gaps = 38/233 (16%)
Query: 12 QEELQNKSQQLRAWEAEKYNEIRTQEQNI-----------QHLNHSLSHKEQLLQEFREL 60
+++L+ K+ Q + K NEI Q++ I Q L ++ KEQL + +E
Sbjct: 1018 KQDLEAKNTQTLTADV-KDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKEN 1076
Query: 61 LQY--------RDNSDKTLEANEMLLEKLRQRIR---------DKAVALERAIDEKFSAL 103
++ R D+ + E++ ++ I+ D+ +E + EK L
Sbjct: 1077 IEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQL 1136
Query: 104 EEKEKELRQLRLAVRE---RDHDLERLRDVLSSNEATMQTMES----LLRAKGLEVEQLS 156
+EK+++L ++ + E + +++E L++ L + E T++ ME+ L + E++
Sbjct: 1137 QEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVK 1196
Query: 157 TTCQNLQWLKEEMETKFSRWQKEQESIIQQLQ-TSLHDRNKEVEARLQLTLRQ 208
+ + + LK E++ F + I++++ T L + + A + L Q
Sbjct: 1197 SITKERKVLK-ELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQ 1248
Score = 32.7 bits (73), Expect = 0.23
Identities = 42/214 (19%), Positives = 91/214 (42%), Gaps = 26/214 (12%)
Query: 5 RKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYR 64
R L+ ++E L+ + QL+ E +++ ++ ++ L ++ + + R ++
Sbjct: 1688 RDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIV--- 1744
Query: 65 DNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL 124
S+KT E + M +K + D A + I E ELR + ++E+ +
Sbjct: 1745 --SEKTNEISNM--QKDLEHSNDALKAQDLKIQE----------ELRIAHMHLKEQQETI 1790
Query: 125 ERLRDVLSSNEATMQTMESLLRAKGL----EVEQLSTTCQNLQWLKE---EMETKFSRWQ 177
++LR ++S + M+ L ++++L L LK+ E + K S +
Sbjct: 1791 DKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEME 1850
Query: 178 KEQESIIQQLQT--SLHDRNKEVEARLQLTLRQL 209
+ ++ I Q T L N + +L L ++
Sbjct: 1851 QLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEM 1884
Score = 31.6 bits (70), Expect = 0.51
Identities = 45/216 (20%), Positives = 92/216 (42%), Gaps = 27/216 (12%)
Query: 14 ELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEA 73
EL+N + + K ++I ++ ++ N ++ + + E + L+ KT E
Sbjct: 2385 ELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLE------KTKET 2438
Query: 74 NEMLLEKL-------RQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER 126
++L +K+ ++ I D + L + EK +E EKE+ + V + +
Sbjct: 2439 IQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRL 2498
Query: 127 LRDVLSSNEATMQT------MESLLRAKGLEVEQLSTTCQNLQ--WLKEE---METKFSR 175
LR+ L ++ T + K L S QN + LK E +E + S+
Sbjct: 2499 LRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISK 2558
Query: 176 WQKEQESIIQQLQTSLHDR---NKEVEARLQLTLRQ 208
+++ E +I+Q L + + EV+ + TL++
Sbjct: 2559 LKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKR 2594
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 63.5 bits (153), Expect = 1e-10
Identities = 56/219 (25%), Positives = 103/219 (47%), Gaps = 34/219 (15%)
Query: 1 MEELRKALQQLQEELQNKSQQL----RAWEAE--KYNEIRTQEQNIQHLNHSL-SHKEQL 53
+++L QQL+ L+ Q+L +A++A K NE+R + ++ N+ L SH EQ
Sbjct: 439 LDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQK 498
Query: 54 LQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQL 113
+E L N + L ++ E+++ + + L R + EK + +E L +L
Sbjct: 499 AREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETML-RDLQEKINQ-QENSLTLEKL 556
Query: 114 RLAV--------------RERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTC 159
+LAV ++R+H +E+L D LS E + + S L K E E+L
Sbjct: 557 KLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEEL---- 612
Query: 160 QNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEV 198
+E +T FS W+ E E ++ Q+++ + ++
Sbjct: 613 -------KEEKTLFSCWKSENEKLLTQMESEKENLQSKI 644
Score = 52.0 bits (123), Expect = 4e-07
Identities = 53/217 (24%), Positives = 99/217 (45%), Gaps = 17/217 (7%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYN--EIRTQEQNI-QHLNHSLSHKEQLLQEF 57
MEE++K L+ + K++++ EAE N + Q QN + + + +E +L++
Sbjct: 481 MEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDL 540
Query: 58 RELLQYRDNSDKTLEANEML---LEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLR 114
+E + ++NS TLE ++ LEK R +D E I++ L + EKE + L
Sbjct: 541 QEKINQQENS-LTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALL 599
Query: 115 LAVRERDHDLERLRDV-------LSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKE 167
A+ + + E L++ S NE + MES ++ L T + Q
Sbjct: 600 SALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSH 659
Query: 168 EMETKFSRWQKEQESI---IQQLQTSLHDRNKEVEAR 201
E + + ++E++ I+ L L ++ EVE +
Sbjct: 660 EYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQ 696
Score = 51.6 bits (122), Expect = 5e-07
Identities = 52/223 (23%), Positives = 103/223 (46%), Gaps = 19/223 (8%)
Query: 1 MEELRKALQQLQEE---LQNKSQQLRAWEAEKYNEIRTQE----QNIQHLNHSLSHKEQL 53
ME L+ L++L E L N + +A E +++ E Q +Q L+ + ++ L
Sbjct: 2440 MEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL 2499
Query: 54 LQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQL 113
L+Q ++ + LE + + +L+ +I+D + + K S +E + + ++
Sbjct: 2500 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQD-----QEQLVSKLSQVEGEHQLWKEQ 2554
Query: 114 RLAVRERDHDLERLRDVLSSNEATMQTMESLLRA--KGLEVEQLSTTCQNLQWLKE--EM 169
L +R +LE+ VL S A++Q +L++ K LE E T + ++++ +M
Sbjct: 2555 NLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKM 2614
Query: 170 ETKFSRWQKEQESIIQ---QLQTSLHDRNKEVEARLQLTLRQL 209
K + Q+E + Q +LQ L + LQL L ++
Sbjct: 2615 TAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEI 2657
Score = 43.5 bits (101), Expect = 1e-04
Identities = 54/207 (26%), Positives = 90/207 (43%), Gaps = 28/207 (13%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
+ EL K LQE+LQ+ + +A K E I LN KE L++E L
Sbjct: 2023 VSELLKDKTHLQEKLQSLEKDSQALSLTKCE----LENQIAQLN---KEKELLVKESESL 2075
Query: 61 LQYRDNSD-------KTLEANEMLLEKLRQRIR-----DKAVALERAIDEKFSALEEKEK 108
SD K LEA L+EK +R ++ L R I++ +E EK
Sbjct: 2076 QARLSESDYEKLNVSKALEA--ALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEK 2133
Query: 109 ELRQLRLAVRERDHDLERLRDVLSSNEATMQTMES-----LLRAKG--LEVEQLSTTCQN 161
+ + ++ER+ + + L+D + + E +Q E +L A+ EVE L T +
Sbjct: 2134 KQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEE 2193
Query: 162 LQWLKEEMETKFSRWQKEQESIIQQLQ 188
+ + E + E+E++ +Q+Q
Sbjct: 2194 MARSLKVFELDLVTLRSEKENLTKQIQ 2220
Score = 41.2 bits (95), Expect = 6e-04
Identities = 50/186 (26%), Positives = 83/186 (44%), Gaps = 30/186 (16%)
Query: 37 EQNIQHLNHSLSHKEQ----LLQEFRELLQYR----DNSDKTLEANEMLLEKLRQRI--- 85
+ + L SL ++Q L ++ EL+Q + +N K + ++ + + QRI
Sbjct: 829 QNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKL 888
Query: 86 RDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLL 145
++ A + + E SALE KEKEL+ L V +++ L+ SN LL
Sbjct: 889 QEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELK---KSNH--------LL 937
Query: 146 RAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQLT 205
E++ LS T L K+EM + S ++E E + Q+ T KE+ A L
Sbjct: 938 EDSLKELQLLSET---LSLEKKEMSSIISLNKREIEELTQENGTL-----KEINASLNQE 989
Query: 206 LRQLVQ 211
L+Q
Sbjct: 990 KMNLIQ 995
Score = 40.8 bits (94), Expect = 8e-04
Identities = 50/205 (24%), Positives = 92/205 (44%), Gaps = 39/205 (19%)
Query: 2 EELRKALQQLQEELQ--NKSQQLRAWEAEKYN-EIRTQEQNIQHLNHSL----------- 47
+ L+ ++ L+ ELQ ++Q+L +AE E+ T + I+ + SL
Sbjct: 2150 DSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLR 2209
Query: 48 SHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKE 107
S KE L ++ +E DK L + + LLE+ Q A + +E +A+E +
Sbjct: 2210 SEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQ-------AEIQIKEESKTAVEMLQ 2262
Query: 108 KELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKE 167
+L++L AV D E ++ AT Q+++ + E QL + E
Sbjct: 2263 NQLKELNEAVAALCGDQEIMK-------ATEQSLDPPIE----EEHQLRNSI-------E 2304
Query: 168 EMETKFSRWQKEQESIIQQLQTSLH 192
++ + +K+Q ++QQL+ S H
Sbjct: 2305 KLRARLEADEKKQLCVLQQLKESEH 2329
Score = 40.8 bits (94), Expect = 8e-04
Identities = 47/238 (19%), Positives = 102/238 (42%), Gaps = 37/238 (15%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS---------HKE 51
M E+ + +LQEEL + +L EI++ + ++ L S HK+
Sbjct: 2625 MHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKD 2684
Query: 52 QLLQEFR---ELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEK 108
Q+ +E + E+ +Y+ + + ++ LL ++ + + K L ++
Sbjct: 2685 QVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKL 2744
Query: 109 ELRQLRLAVRERDHDLERLRDVLSSNEATM--------QTMESLLRAKGLEVEQLSTTCQ 160
E+ L+ + E ++ L+ +L + T Q + RA+G +++ L +C+
Sbjct: 2745 EIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQG-KMKLLIKSCK 2803
Query: 161 NLQWLKEEMETKFSRWQKEQE----------------SIIQQLQTSLHDRNKEVEARL 202
L+ KE ++ + S+ Q QE + I++L+ +L ++ KE + L
Sbjct: 2804 QLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYL 2861
Score = 35.0 bits (79), Expect = 0.047
Identities = 41/195 (21%), Positives = 92/195 (47%), Gaps = 13/195 (6%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHK-EQLLQEFRE 59
+E L L E +N+ +QL+ A+++ E T+ + N +L + E + Q R
Sbjct: 1053 LECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRS 1112
Query: 60 LLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRE 119
+ N+ K+ EA + E + ++++ +++ +++ L+E E+ ++ ++
Sbjct: 1113 EMTDNQNNSKS-EAGGLKQEIMT--LKEEQNKMQKEVND---LLQENEQLMKVMKTKHEC 1166
Query: 120 RDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEM-----ETKFS 174
++ + E +R+ + E+ + LEV+++S N Q ++ E E K
Sbjct: 1167 QNLESEPIRNSVKERESERNQC-NFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQ 1225
Query: 175 RWQKEQESIIQQLQT 189
+KE+E + +LQT
Sbjct: 1226 ESEKEKECLQHELQT 1240
Score = 34.7 bits (78), Expect = 0.061
Identities = 43/199 (21%), Positives = 93/199 (46%), Gaps = 30/199 (15%)
Query: 24 AWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQY------RDNSDKT-----LE 72
+W+ E++ ++ + I+ S+ H+ L+ E++Q +DN +K LE
Sbjct: 1892 SWK-ERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLE 1950
Query: 73 ANEMLLEKLRQRIRDKAVALER---AIDEKFSALEEKEKELRQ--------LRLAVRERD 121
++ R ++R + + + A+D+ ++EK +EL +++A E
Sbjct: 1951 EELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVK 2010
Query: 122 HDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 181
E L+ LSS+ + + ++ L+ K ++ L Q L K E+E + ++ KE+E
Sbjct: 2011 EKTELLQ-TLSSDVSELLKDKTHLQEK---LQSLEKDSQALSLTKCELENQIAQLNKEKE 2066
Query: 182 SIIQQ---LQTSLHDRNKE 197
++++ LQ L + + E
Sbjct: 2067 LLVKESESLQARLSESDYE 2085
Score = 33.1 bits (74), Expect = 0.18
Identities = 27/133 (20%), Positives = 65/133 (48%), Gaps = 8/133 (6%)
Query: 6 KALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD 65
+ALQ++QE L+ + +L+ + ++ ++ + E +Q K+++ E E +
Sbjct: 15 RALQKIQE-LEGQLDKLKKEKQQRQFQLDSLEAALQ------KQKQKVENEKTEGTNLKR 67
Query: 66 NSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLE 125
+ + +E E L EK +Q+I + E ++ + L +K++ +L ++ +LE
Sbjct: 68 ENQRLMEICESL-EKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELE 126
Query: 126 RLRDVLSSNEATM 138
R + S + ++
Sbjct: 127 RSQQAAQSADVSL 139
Score = 31.6 bits (70), Expect = 0.51
Identities = 41/199 (20%), Positives = 84/199 (42%), Gaps = 26/199 (13%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAE------KYNEIRTQEQNIQHLNHSLSHKEQLLQ 55
EE K +++ + LQ Q ++ + + + IR + + + + K Q+
Sbjct: 1137 EEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDL 1196
Query: 56 EFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRL 115
E +E+ +L++ L +L +R+K + L+ + EKEKE Q L
Sbjct: 1197 EVKEI---------SLDSYNAQLVQLEAMLRNKELKLQES---------EKEKECLQHEL 1238
Query: 116 AVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLE-VEQLSTTCQNLQWLKEEMETKFS 174
D + L+D+ S + ++ E K + +LST+ + L+ ++T +
Sbjct: 1239 QTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMN 1298
Query: 175 RWQKEQESIIQQLQTSLHD 193
+ E E I + LQ ++
Sbjct: 1299 K-LNELEKICEILQAEKYE 1316
Score = 29.3 bits (64), Expect = 2.6
Identities = 45/216 (20%), Positives = 88/216 (40%), Gaps = 20/216 (9%)
Query: 3 ELRKALQQLQEELQNK--------SQQLRAWEAEKY-NEIRTQEQNI---QHLNHSLSHK 50
+ +KA Q L + N S + +W+ EK + + + Q + + S
Sbjct: 189 QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSG 248
Query: 51 EQLLQEFRELLQY--RDNSDKTLE--ANEMLLEKLRQRIRDKAVALERAIDEKFSALEEK 106
EQ + R LQ RD + + ++ LL++L+ + ++ L I+E L+
Sbjct: 249 EQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQE----LRNKINELELRLQGH 304
Query: 107 EKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLK 166
EKE++ +E LE+ + L E + L + +Q ST L+
Sbjct: 305 EKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKL 364
Query: 167 EEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEARL 202
+++ S ++ ES L+ + ++ KE + L
Sbjct: 365 KKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEEL 400
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 57.0 bits (136), Expect = 1e-08
Identities = 52/207 (25%), Positives = 96/207 (46%), Gaps = 17/207 (8%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ----E 56
++EL+ L+Q + L K + +++ EI +Q +Q KEQ LQ E
Sbjct: 1748 LQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDE 1807
Query: 57 FRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLA 116
+ L RD + L+ + + +R+++KA AL+ A+++ L+E+ EL
Sbjct: 1808 AQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGEL------ 1861
Query: 117 VRERDHDLERLRDVLSSNEATMQTMESL---LRAKGLEVEQLSTTCQNLQWLKEEMETKF 173
++ RL + L+ +Q +E + LRA+ E E+ Q Q E+ +
Sbjct: 1862 -QDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ--QQCAEQAQEHE 1918
Query: 174 SRWQKEQESIIQQLQTSLHDRNKEVEA 200
+ Q+S + Q Q L +R++E+EA
Sbjct: 1919 VETRALQDSWL-QAQAVLKERDQELEA 1944
Score = 53.9 bits (128), Expect = 1e-07
Identities = 47/223 (21%), Positives = 109/223 (48%), Gaps = 26/223 (11%)
Query: 5 RKALQQLQEELQNKSQQLRAWEAE---KYNEIRTQEQNIQHLNHSLSHKEQLLQEFR--- 58
R AL+ EE++++ ++ +A + + K + + ++N+ L +L+ +E+ ++ R
Sbjct: 1385 RSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQI 1444
Query: 59 -ELLQYRDNSDKTLEANEMLLEKLRQRI---RDKAVALERA---IDEKFSALEEKEKELR 111
EL + R+ LE + L+K Q + +++ LE+ ++ A++E+E++L
Sbjct: 1445 QELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLT 1504
Query: 112 QLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 171
R +RE + D E R+VL ++ + ++ ++ +V+ L L+ L E+E
Sbjct: 1505 VQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEE 1564
Query: 172 KFSRWQKEQESI-------------IQQLQTSLHDRNKEVEAR 201
+ + +Q+ I + L L +R++E++A+
Sbjct: 1565 NHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQ 1607
Score = 53.1 bits (126), Expect = 2e-07
Identities = 57/235 (24%), Positives = 105/235 (44%), Gaps = 59/235 (25%)
Query: 8 LQQLQEELQNKSQQLRAWEA----------EKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 57
L++ +ELQ +S Q+ E+ E+ E+++Q + I+ L KE L Q+
Sbjct: 1597 LEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQR---QKEHLTQD- 1652
Query: 58 RELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAV 117
L+ RD E++L+K R ++ + D++ + E++L Q++L++
Sbjct: 1653 ---LERRD--------QELMLQKERIQVLE---------DQRTRQTKILEEDLEQIKLSL 1692
Query: 118 RERDHDLERLRDVL-----------SSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLK 166
RER +L R ++ + +++ M+ +LR K EVE LQ LK
Sbjct: 1693 RERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELK 1752
Query: 167 EEM------------ETKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLRQL 209
+++ ET Q+EQE ++ LQ L + ++ E + Q QL
Sbjct: 1753 DQLEQQLQGLHRKVGETSLLLSQREQEIVV--LQQQLQEAREQGELKEQSLQSQL 1805
Score = 50.1 bits (118), Expect = 1e-06
Identities = 54/203 (26%), Positives = 93/203 (45%), Gaps = 23/203 (11%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
E+ R ALQ E + + + L WE K + Q Q + L + +QE +E +
Sbjct: 637 EQARNALQVDLAEAEKRREAL--WE--KNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI 692
Query: 62 QYR-DNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
Q + S EA LE+L Q + + L RA+ EK + + +EK ++RL ER
Sbjct: 693 QKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALV--REKAALEVRLQAVER 750
Query: 121 DHD--------LERLRDVLSSNEATMQTMESLLR-AKGLEVEQLSTTCQ-------NLQW 164
D L +++L S+ Q S++ KG Q+ T Q ++
Sbjct: 751 DRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRC 810
Query: 165 LKEEMETKFSRWQKEQESIIQQL 187
LK E++T+ S+ ++E+++ +QL
Sbjct: 811 LKLELDTERSQAEQERDAAARQL 833
Score = 48.1 bits (113), Expect = 5e-06
Identities = 68/269 (25%), Positives = 110/269 (40%), Gaps = 65/269 (24%)
Query: 1 MEELRKALQQL--QEELQNKSQQLRAWEAEKYN-EIRTQEQNIQ----------HLNHSL 47
+E LR +Q+L Q E+Q + +L + + +K N E+ Q++ IQ HL ++
Sbjct: 1437 VETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAV 1496
Query: 48 SHKEQLL----QEFRELLQYRDNSDKTLEANEMLLEKLRQRIRD---------------K 88
+EQ L ++ REL + R+ LE + LEK Q I +
Sbjct: 1497 QEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLE 1556
Query: 89 AVALE------------RAIDEKFSALEEKEKELRQLRLAVRERD----------HDLER 126
+ALE + I E E + L L L + ER HDLE
Sbjct: 1557 CLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLES 1616
Query: 127 LRDVLSSN--------EATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEE---METKFSR 175
VL+ ++ + +E L R K + L Q L KE +E + +R
Sbjct: 1617 HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTR 1676
Query: 176 WQKEQESIIQQLQTSLHDRNKEVEARLQL 204
K E ++Q++ SL +R +E+ + QL
Sbjct: 1677 QTKILEEDLEQIKLSLRERGRELTTQRQL 1705
Score = 46.2 bits (108), Expect = 2e-05
Identities = 58/219 (26%), Positives = 97/219 (44%), Gaps = 23/219 (10%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQ--HLNHSLSHKEQLLQEFRE 59
EEL A+++ +E LQ L A ++E +E+ T + ++ HL L +EQ E
Sbjct: 512 EELHLAVRE-RERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQT--EVTA 568
Query: 60 LLQYRDNSDKTLEANEMLLEKLRQRIRDKAV---ALERAIDEKFSALEEKEKELRQLRLA 116
L + S L ++E L+ +R AV AL A+ L ++ +L + +
Sbjct: 569 ALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQS 628
Query: 117 VRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVE-----------QLSTTCQNLQWL 165
V R E+ R+ L + A + L K +E +L +++Q
Sbjct: 629 VCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEE 688
Query: 166 KEEMETKFSRWQKEQESIIQQLQTSLHD---RNKEVEAR 201
KEE++ K S + +QE+ QL+ LH R +EV AR
Sbjct: 689 KEEIQKKLSESRHQQEAATTQLE-QLHQEAKRQEEVLAR 726
Score = 45.1 bits (105), Expect = 4e-05
Identities = 59/212 (27%), Positives = 101/212 (47%), Gaps = 36/212 (16%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAE-------------KYNEIRTQEQNIQHLNHSL 47
+++LR+ L QE + QQ WE E + + + Q ++Q SL
Sbjct: 402 VQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSL 461
Query: 48 SHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKE 107
S + +LLQ+ RE L+ + LE +LE+ R+R V L+ D SA +KE
Sbjct: 462 SKERELLQKAREELRQQ------LE----VLEQEAWRLRRVNVELQLQGD---SAQGQKE 508
Query: 108 KELRQLRLAVRERDHDLERLRDVLSSNEATM-QTMESLLRAKGLEVEQLSTTCQNLQWLK 166
++ +L LAVRER ERL+++L EA +++ L+ + E L ++ + L+
Sbjct: 509 EQQEELHLAVRER----ERLQEMLMGLEAKQSESLSELITLR----EALESSHLEGELLR 560
Query: 167 EEMETKFSRWQKEQESIIQQLQTSLHDRNKEV 198
+E +T+ + E I +L +S + EV
Sbjct: 561 QE-QTEVTAALARAEQSIAELSSSENTLKTEV 591
Score = 45.1 bits (105), Expect = 4e-05
Identities = 50/225 (22%), Positives = 95/225 (42%), Gaps = 23/225 (10%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
++ L + L L+ E + + + L A + + + + E + L S + +L+E
Sbjct: 1882 VQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKE---- 1937
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
RD + L A + R +A AL+ A+ + +AL+ KE+ L + R
Sbjct: 1938 ---RDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSL 1994
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEV--------EQLSTTCQNLQWLKEEMETK 172
+ L+ L + +A + +E LR + E+ E + Q L EE+ +
Sbjct: 1995 EASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQ 2054
Query: 173 FSRWQ--------KEQESIIQQLQTSLHDRNKEVEARLQLTLRQL 209
R Q + QE++IQ+ Q +R +E L ++R+L
Sbjct: 2055 QEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVREL 2099
Score = 43.9 bits (102), Expect = 1e-04
Identities = 52/217 (23%), Positives = 97/217 (44%), Gaps = 27/217 (12%)
Query: 3 ELRKALQQLQEELQNKS-------QQLRAWEAEKYNEIRTQEQNIQHLNHSLSHK--EQL 53
+L +AL+ + E+Q++ QQL+ A++ E+R Q++ Q L SL+ + E +
Sbjct: 2014 QLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENM 2073
Query: 54 LQEFRELLQYRDNSD------------KTLEANEMLLEKLRQ-RIRDKAVALERAIDEKF 100
+QE + L Q R+ + TL E + +LR+ + R+ AL + K
Sbjct: 2074 IQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHS--HKT 2131
Query: 101 SALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQ 160
S +EE+ +L L ++ +LERL+ L EA + L + Q +
Sbjct: 2132 SPMEEQSLKLDSLEPRLQ---RELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVS 2188
Query: 161 NLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKE 197
+LQ + ++ EQ+ + +L+ + KE
Sbjct: 2189 SLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE 2225
Score = 42.4 bits (98), Expect = 3e-04
Identities = 51/180 (28%), Positives = 81/180 (45%), Gaps = 44/180 (24%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWE---AEKYN--------EIRTQEQNIQHLNHSLSHK 50
EELR QQ +E+L KS R E EK N EIR Q+++ L +L+ K
Sbjct: 2049 EELRH--QQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQK 2106
Query: 51 EQLLQEFRELLQYRD-----NSDKT--LEANEMLLEKLRQRI------------------ 85
EQ + E RE Q + +S KT +E + L+ L R+
Sbjct: 2107 EQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEARE 2166
Query: 86 ---RDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTME 142
R+KA L ++ + +++ ++ L+ +V ERD + +RL+D L E T + +E
Sbjct: 2167 IEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDEL---ELTRRALE 2223
Score = 41.6 bits (96), Expect = 5e-04
Identities = 47/225 (20%), Positives = 107/225 (47%), Gaps = 31/225 (13%)
Query: 2 EELRKALQQLQEE-------LQNKSQQLRAWEAEKYNE------------IRTQEQNIQH 42
+EL KAL+ L+ E L+ + ++ A +A++ E + T+++ +
Sbjct: 871 QELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSL 930
Query: 43 LNHSLSHKEQLLQEFRELLQYRDNSD----KTLEANEMLLEKLRQRIRDKAVALERAIDE 98
L L +++L ++L + R + K E +L +L++ R+ A + D+
Sbjct: 931 LETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDD 990
Query: 99 KFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTT 158
+AL+E+ L Q ++ ++++ +E L+ L + + + + +E ++ K E ++ +
Sbjct: 991 -LAALQEESSSLLQDKMDLQKQ---VEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRI 1046
Query: 159 CQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQ 203
+ L+ +E+ S +KEQ ++ Q S+ R +E+ A Q
Sbjct: 1047 QKELE--REKASLTLSLMEKEQRLLVLQEADSI--RQQELSALRQ 1087
Score = 41.2 bits (95), Expect = 6e-04
Identities = 42/233 (18%), Positives = 103/233 (44%), Gaps = 29/233 (12%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLL----QE 56
+E+++ +L++ EL + Q ++ E + Q +++H+ L KE+ + +
Sbjct: 1685 LEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEH 1744
Query: 57 FRELLQYRDNSDKTLEA--------------NEMLLEKLRQRIRD-------KAVALERA 95
EL + +D ++ L+ E + L+Q++++ K +L+
Sbjct: 1745 IHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQ 1804
Query: 96 IDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQL 155
+DE AL ++++EL L+ ++ ER+++ + + ++ L+ + E++
Sbjct: 1805 LDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDH 1864
Query: 156 STTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLRQ 208
+ L+ EE+ + R Q +E ++ L+ ++ K + A Q Q
Sbjct: 1865 KEQARRLE---EELAVEGRRVQALEE-VLGDLRAESREQEKALLALQQQCAEQ 1913
Score = 38.9 bits (89), Expect = 0.003
Identities = 48/207 (23%), Positives = 94/207 (45%), Gaps = 20/207 (9%)
Query: 4 LRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQE----------QNIQHLNHSLSHKEQL 53
L+ + Q Q L+ + Q+L A AE + +E + + + +L KEQ
Sbjct: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQH 1983
Query: 54 LQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQL 113
L E EL + + S TL+A+ + +++ + E I ++ +E +++QL
Sbjct: 1984 LLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQE---DVQQL 2040
Query: 114 RLAVRERDHDL--ERLRDVLSSNEATMQTMESLLRAK-GLEVEQLSTTCQNLQWLKEEME 170
+ A+ +RD +L ++ R+ L + E++++ K L E+ + L E++
Sbjct: 2041 QQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQ 2100
Query: 171 TKFSRWQKEQESIIQQLQTSLHDRNKE 197
+ QKEQE I +L+ + N E
Sbjct: 2101 LTLA--QKEQE--ILELRETQQRNNLE 2123
Score = 37.7 bits (86), Expect = 0.007
Identities = 47/220 (21%), Positives = 104/220 (47%), Gaps = 28/220 (12%)
Query: 4 LRKALQQLQEELQNKSQQL-RAWEAEKYNEIRTQEQN------IQHLNHSLSHKEQLLQE 56
L + L Q Q+EL + SQQL R + K +++ QE +Q L KE Q
Sbjct: 930 LLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQREL--KEAARQH 987
Query: 57 FRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQ---- 112
+L ++ S L+ ++M L+K + ++ + VA + + ++EK +E ++
Sbjct: 988 RDDLAALQEESSSLLQ-DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRI 1046
Query: 113 ----------LRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNL 162
L L++ E++ L L++ S + + + ++ E ++LS +
Sbjct: 1047 QKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSA---QM 1103
Query: 163 QWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEARL 202
+ L++E++ K + + ++ ++++L+ S H +++ A L
Sbjct: 1104 ELLRQEVKEKEADFLAQEAQLLEELEAS-HITEQQLRASL 1142
Score = 37.7 bits (86), Expect = 0.007
Identities = 52/218 (23%), Positives = 92/218 (42%), Gaps = 44/218 (20%)
Query: 3 ELRKALQQLQEEL--QNKSQQL-------RAWEAEKYNEIRTQ---------------EQ 38
+L+K ++ L+ +L Q+ SQ+L + E ++YN I+ + EQ
Sbjct: 1007 DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQ 1066
Query: 39 NIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKA---VALERA 95
+ L + S ++Q L R+ +Q K L A +E LRQ +++K +A E
Sbjct: 1067 RLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQ---MELLRQEVKEKEADFLAQEAQ 1123
Query: 96 IDEKFSALEEKEKELR-----------QLRLAVRERDHDLERL-RDVLSSNEATMQTMES 143
+ E+ A E++LR QL+L +R + LE L + N+A Q
Sbjct: 1124 LLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQA--QAQAQ 1181
Query: 144 LLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 181
L + L + C++ L ++ S W E +
Sbjct: 1182 LASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPD 1219
Score = 35.4 bits (80), Expect = 0.036
Identities = 33/199 (16%), Positives = 87/199 (43%), Gaps = 19/199 (9%)
Query: 9 QQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSD 68
Q+L++E +SQ+L +++ E + + L+ L+ ++ +++ +++
Sbjct: 254 QELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMI------- 306
Query: 69 KTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRE-------RD 121
K L +LE + + +L R E+ +L++ K++ Q+ + + +
Sbjct: 307 KALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHE 366
Query: 122 HDLERLRDVLS-----SNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRW 176
+ LE + S + + + S+L + V+ L Q ++ + +W
Sbjct: 367 NSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQW 426
Query: 177 QKEQESIIQQLQTSLHDRN 195
++E +++ Q+LQ +R+
Sbjct: 427 EEEGKALRQRLQKLTGERD 445
Score = 34.7 bits (78), Expect = 0.061
Identities = 41/159 (25%), Positives = 71/159 (44%), Gaps = 25/159 (15%)
Query: 58 RELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAI--DEKFSALEEKEKELRQLRL 115
R+L Q LE + EK ++R+K ER+ E ALE E+E +L +
Sbjct: 831 RQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEK-ERSWHQQELAKALESLEREKMELEM 889
Query: 116 AVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVE---------------QLSTTCQ 160
++E+ ++E ++ + E ES L LE E +L+ Q
Sbjct: 890 RLKEQQTEMEAIQ---AQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQ 946
Query: 161 NLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVE 199
L+ L+++M+ + KEQE+ LQT L + +E++
Sbjct: 947 QLERLRQDMKV---QKLKEQET-TGILQTQLQEAQRELK 981
Score = 33.9 bits (76), Expect = 0.10
Identities = 32/159 (20%), Positives = 69/159 (43%), Gaps = 11/159 (6%)
Query: 31 NEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRI---RD 87
N ++ Q + L+ ++Q+ + + NS + + L+ KL+ ++ R
Sbjct: 9 NNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRS 68
Query: 88 KAVALERAIDEKFSALEEK-----EKELRQLRLAVRERDHDLERLRDVLSSNEATMQTME 142
LE+ ++ + ++ E L +L + + E E L +V + M+ +
Sbjct: 69 WCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKAD 128
Query: 143 SLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 181
+ +A +VE+L+ ++E+ K S+WQ EQE
Sbjct: 129 VVNKALREDVEKLTVDWSRA---RDELMRKESQWQMEQE 164
Score = 32.3 bits (72), Expect = 0.30
Identities = 39/215 (18%), Positives = 92/215 (42%), Gaps = 34/215 (15%)
Query: 5 RKALQQLQEELQNKSQQLRAWEAEKY----------NEIRTQEQNIQHLNHSLSHKEQLL 54
R+ LQ +E L + + L+A E ++RT ++ N + + +
Sbjct: 1343 RELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERA 1402
Query: 55 QEFRELLQYRDNSDKTLEANEMLL-EKLRQRIRDKAVALERAIDEKFSALEEKEKE---- 109
Q +E + + K L+ N LL + L +R E ++ ++E EK+
Sbjct: 1403 QALQEQGELKVAQGKALQENLALLTQTLAER--------EEEVETLRGQIQELEKQREMQ 1454
Query: 110 ---LRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLK 166
L L L +++R+ +++ ++ + E +E L A ++L+ + ++ L+
Sbjct: 1455 KAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELE 1514
Query: 167 EEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEAR 201
++ ET Q ++++ L +++ +E++
Sbjct: 1515 KDRET--------QRNVLEHQLLELEKKDQMIESQ 1541
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 57.0 bits (136), Expect = 1e-08
Identities = 52/206 (25%), Positives = 95/206 (46%), Gaps = 23/206 (11%)
Query: 4 LRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQY 63
L K L+Q + E + + ++ RA +E+ + L KE+ LQE L +
Sbjct: 321 LHKDLKQKRREQREQRERRRA----------AKEEELLRLQQLQEEKERKLQELELLQEA 370
Query: 64 RDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSA-------LEEKEKELRQLRLA 116
+ +++ L+ E E+ R + R+ ALE + E A +E KE+E + R
Sbjct: 371 QRQAERLLQEEE---ERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQR 427
Query: 117 VRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRW 176
++E + +RL++ L + ES+ A+ +E+ + L LKEE E R
Sbjct: 428 IKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERA 487
Query: 177 QKEQESIIQQL---QTSLHDRNKEVE 199
Q+E+E + Q++ SL +++E
Sbjct: 488 QQEKEELQQEMAQQSRSLQQAQQQLE 513
Score = 51.6 bits (122), Expect = 5e-07
Identities = 55/187 (29%), Positives = 87/187 (46%), Gaps = 22/187 (11%)
Query: 2 EELRKALQQLQEELQNKSQQLR-AWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
EEL + LQQLQEE + K Q+L EA++ E QE+ + + ++ L + RE
Sbjct: 345 EELLR-LQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREA 403
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRD---------KAVALE---RAIDE-----KFSAL 103
Q R + +E E + RQRI++ +A+ LE R +E + L
Sbjct: 404 EQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLL 463
Query: 104 EEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQ 163
EE+E++L+QL E++ +ER + E Q M R+ +QL QN Q
Sbjct: 464 EEEEEKLKQLMQLKEEQERYIERAQ---QEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQ 520
Query: 164 WLKEEME 170
E++E
Sbjct: 521 RADEDVE 527
Score = 37.0 bits (84), Expect = 0.012
Identities = 29/143 (20%), Positives = 65/143 (45%), Gaps = 4/143 (2%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
++EL + Q+LQE LQ + + R E+ + + R E+ + L + KE+ +
Sbjct: 428 IKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERA 487
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
Q ++ + + L++ +Q++ + +RA ++ +E +++LRQ V+
Sbjct: 488 QQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADED----VEAAQRKLRQASTNVKHW 543
Query: 121 DHDLERLRDVLSSNEATMQTMES 143
+ + RL + + T S
Sbjct: 544 NVQMNRLMHPIEPGDKRPVTSSS 566
Score = 30.8 bits (68), Expect = 0.88
Identities = 35/137 (25%), Positives = 61/137 (44%), Gaps = 22/137 (16%)
Query: 75 EMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSN 134
EM RQR ++ A++ AI + K+L+Q R RE+ ER R
Sbjct: 291 EMSASDTRQR-QEWTAAIQMAIRLQAEGKTSLHKDLKQKR---REQREQRERRRAAKE-- 344
Query: 135 EATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDR 194
E LLR + L+ E+ Q L+ L+E Q++ E ++Q+ + +
Sbjct: 345 -------EELLRLQQLQ-EEKERKLQELELLQEA--------QRQAERLLQEEEERRRSQ 388
Query: 195 NKEVEARLQLTLRQLVQ 211
++E++ L+ LR+ Q
Sbjct: 389 HRELQQALEGQLREAEQ 405
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 55.8 bits (133), Expect = 3e-08
Identities = 52/213 (24%), Positives = 105/213 (49%), Gaps = 18/213 (8%)
Query: 9 QQLQEELQNKSQQLRAWEAEKYN---EIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD 65
Q+LQ+ L+N +++++ E+E + E +T ++N++ L S EQL +E + L +
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSL----E 821
Query: 66 NSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLE 125
LE ++ LEK +R+R +A + ++E + EKE + L +
Sbjct: 822 QETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCV 881
Query: 126 RLRDVLSSNE-----ATMQTMESLLRAKGLEVEQLSTTCQN--LQWLKEEMETKFSRWQK 178
RL+++ N+ AT+ + + L E+L T N L+ L E+E +
Sbjct: 882 RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELE----KIGL 937
Query: 179 EQESIIQQLQTSLHDRNKEVEARLQLTLRQLVQ 211
+E ++ Q++ R K +E++L+ TL++ ++
Sbjct: 938 NKERLLHDEQSTDDSRYKLLESKLESTLKKSLE 970
Score = 43.9 bits (102), Expect = 1e-04
Identities = 47/221 (21%), Positives = 103/221 (46%), Gaps = 34/221 (15%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEK---------YNEIRTQEQNIQHLNHSLSHKE 51
++++ K + L E ++ S +L E EK Y E + + +++ H L +
Sbjct: 582 VKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKEN 641
Query: 52 QLLQE-------FRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALE 104
+LLQ+ E ++ + + LE L+K ++ LE +++++ S L+
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLE-SLEKENSQLD 700
Query: 105 EKEKELR--------------QLRLAVRERDHDLERLRDVLSSNEATMQTMESL-LRAKG 149
E+ ELR QL+L +E + + E+L+ L +A+ + E L + +G
Sbjct: 701 EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760
Query: 150 LEVE--QLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQ 188
L++E +L T +N +++E++ + E +++ + L+
Sbjct: 761 LDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801
Score = 41.2 bits (95), Expect = 6e-04
Identities = 52/210 (24%), Positives = 97/210 (46%), Gaps = 24/210 (11%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
EE AL+ EE N +QQLR E++T ++N + L E+ + + +
Sbjct: 973 EEKIAALEARLEESTNYNQQLR-------QELKTVKKNYEALKQR--QDEERMVQSSPPI 1023
Query: 62 QYRDNSDKTLEANEMLLEKLRQRIRDKAVALER---AIDEKFSALEEKEKELRQLRLAVR 118
DN + E+ E E L+ ++D+ + +ER + + AL+ + K+L ++
Sbjct: 1024 SGEDNKWER-ESQETTRELLK--VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 1080
Query: 119 ERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTC--QNLQWLKEEMETKFSRW 176
+ L+R L T+QT + L+ + + ST+ QN Q L ++ S
Sbjct: 1081 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQ-----SSL 1135
Query: 177 QKEQESIIQQLQ--TSLHDRNKEVEARLQL 204
+ E ES+I++ + SL+D + +L+L
Sbjct: 1136 ENENESVIKEREDLKSLYDSLIKDHEKLEL 1165
Score = 40.0 bits (92), Expect = 0.001
Identities = 51/222 (22%), Positives = 92/222 (41%), Gaps = 17/222 (7%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
+E L K QL EE + +LR E + +Q N L +++ L++ EL
Sbjct: 689 LESLEKENSQLDEE----NLELRR-NVESLKCASMKMAQLQLENKELESEKEQLKKGLEL 743
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
L+ + LE + L+ QR++ + I + S L++ E E + L+ + E
Sbjct: 744 LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL 803
Query: 121 DHDLERLRDVLSSNEATMQTMESLLR-AKGLEVE--QLSTTCQNLQWLKEEMETKFSRWQ 177
+RL + N++ Q L + K LE E +L + EE K +
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863
Query: 178 KEQESIIQQL---------QTSLHDRNKEVEARLQLTLRQLV 210
KE +++ +++ L NKE+ R + ++ LV
Sbjct: 864 KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905
Score = 38.9 bits (89), Expect = 0.003
Identities = 39/199 (19%), Positives = 87/199 (43%), Gaps = 21/199 (10%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
+E ++L + EEL+ + ++I E+ Q L+ + E + + ++
Sbjct: 465 LEMENQSLTKTVEELRTTVDSVEG----NASKILKMEKENQRLSKKVEILENEIVQEKQS 520
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
LQ N K L + LEK + +R+ + + + LE++ + L Q ++R+R
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENS-------ERQIKILEQENEHLNQTVSSLRQR 573
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ 180
S EA ++ +E + +++ S+ +++ K +++ + + KE+
Sbjct: 574 SQ---------ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY-KEK 623
Query: 181 ESIIQQLQTSLHDRNKEVE 199
++L+ LH KE E
Sbjct: 624 GERAEELENELHHLEKENE 642
Score = 34.3 bits (77), Expect = 0.079
Identities = 46/245 (18%), Positives = 110/245 (44%), Gaps = 43/245 (17%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEA--EKYNEIRTQEQNIQHLNHSLSHKEQLLQEFR 58
+E++ L++LQ+E N R+ ++ + +R + + L +S ++ L +
Sbjct: 281 LEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIE 340
Query: 59 ELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELR-QLRLAV 117
Y+ ++ E N++LLE + + + + RA +K LE++ +L+ +L
Sbjct: 341 F---YKARVEELKEDNQVLLET--KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDME 395
Query: 118 RERDHDLERLRDVLSSNE----ATMQTMESLL--------------------RAKGLEVE 153
ERD D +++ +++ N A Q+M+ L ++ G EV
Sbjct: 396 MERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVN 455
Query: 154 QLSTTCQNLQWLKEEMETK-FSRWQKEQESIIQQLQ------TSLHDRNKEVEARLQLTL 206
+L+++ + LK EME + ++ +E + + ++ + N+ + ++++
Sbjct: 456 ELTSS----RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILE 511
Query: 207 RQLVQ 211
++VQ
Sbjct: 512 NEIVQ 516
Score = 28.9 bits (63), Expect = 3.3
Identities = 44/222 (19%), Positives = 97/222 (43%), Gaps = 23/222 (10%)
Query: 5 RKALQQLQEEL---QNKSQQLRAWEAEKYNEIRTQEQNIQ--HLNHSLSHKEQLLQEFRE 59
R+ L+ L + L K + L +A +Y + ++ ++ H N + H++ L + +
Sbjct: 1146 REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRD-LEDRYNQ 1204
Query: 60 LLQYR---DNSDKTL--EANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLR 114
LL+ + ++ +K L E +MLLE + + A + + + L +L +
Sbjct: 1205 LLKQKGQLEDLEKMLKVEQEKMLLEN---KNHETVAAEYKKLCGENDRLNHTYSQLLK-E 1260
Query: 115 LAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS 174
V + DH + L+ +L++++ +E+ + +QL T L E +
Sbjct: 1261 TEVLQTDH--KNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG 1318
Query: 175 RWQKEQESIIQQLQT------SLHDRNKEVEARLQLTLRQLV 210
++E ++ Q+QT +L ++N E + + RQ +
Sbjct: 1319 NLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYI 1360
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 55.5 bits (132), Expect = 3e-08
Identities = 50/206 (24%), Positives = 96/206 (46%), Gaps = 21/206 (10%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAE-KYNEIR--TQEQNIQHLNHSLSHKEQLLQEF 57
++ LRKA + + E++ QQL A E + K+ EI + + L +E L
Sbjct: 730 LDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNL 789
Query: 58 RELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAV 117
+E L +TLE +L++ ++AV+++R++ E + L +KE++ L
Sbjct: 790 QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNML---- 845
Query: 118 RERDHDLERLRDVLSSNEATM----QTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKF 173
DLE+LR+ L+ EA + E L++AK E+L + + + ++
Sbjct: 846 ---SSDLEKLRENLADMEAKFREKDEREEQLIKAK----EKLENDIAEIMKMSGDNSSQL 898
Query: 174 SRWQKE---QESIIQQLQTSLHDRNK 196
++ E +E +++LQ L N+
Sbjct: 899 TKMNDELRLKERDVEELQLKLTKANE 924
Score = 52.8 bits (125), Expect = 2e-07
Identities = 54/213 (25%), Positives = 106/213 (49%), Gaps = 26/213 (12%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
MEE RK ++ L++ KSQQL A + E ++ E+ + + SH Q L+E R +
Sbjct: 1105 MEEFRKEIETLKQAAAQKSQQLSALQEE---NVKLAEELGRSRDEVTSH--QKLEEERSV 1159
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLR---LAV 117
L +++ LE + + ++ +KA +L+++I + L EK+ EL +LR +
Sbjct: 1160 L-----NNQLLEMKKRESKFIKDADEEKA-SLQKSISITSALLTEKDAELEKLRNEVTVL 1213
Query: 118 RERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVE------QLSTTCQNLQWLKEEMET 171
R + + L V+ + E+ +E L+ K LE++ QLS++ N +E E
Sbjct: 1214 RGENASAKSLHSVVQTLESDKVKLE--LKVKNLELQLKENKRQLSSSSGNTDTQADEDE- 1270
Query: 172 KFSRWQKEQESIIQQLQTSLHDRNKEVEARLQL 204
R Q+ Q + + L +N++++ ++++
Sbjct: 1271 ---RAQESQIDFLNSVIVDLQRKNQDLKMKVEM 1300
Score = 45.8 bits (107), Expect = 3e-05
Identities = 44/193 (22%), Positives = 88/193 (45%), Gaps = 6/193 (3%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQN-IQHLNHSLSHKEQLLQ--EF 57
+E++R Q E LQN+ RA A++ +R + I+ +SL L E
Sbjct: 617 IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED 676
Query: 58 RELLQYRDNSDKTLEANEML--LEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRL 115
+ L++ D +K EA + LE L+ + ++ ++ + A EEK +L LR
Sbjct: 677 QHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDN-FTSQLKATEEKLLDLDALRK 735
Query: 116 AVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSR 175
A E ++++LR L + E ++ +E A+ + ++ Q + ++ S
Sbjct: 736 ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSE 795
Query: 176 WQKEQESIIQQLQ 188
+ +E++ ++LQ
Sbjct: 796 VSQVKETLEKELQ 808
Score = 40.4 bits (93), Expect = 0.001
Identities = 42/217 (19%), Positives = 92/217 (42%), Gaps = 11/217 (5%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
++E + Q++E L+ + Q L+ AE E + ++++Q + L KE+
Sbjct: 789 LQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSD 848
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
L+ + +EA ++ +++ LE I E + +L ++ +R +
Sbjct: 849 LEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK 908
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQ-LSTTCQNLQWLKEEMETKFSRWQKE 179
+ D+E L+ L+ ++ + ++ EQ + + K+E+E K S +K+
Sbjct: 909 ERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKK 968
Query: 180 QESIIQQLQ----------TSLHDRNKEVEARLQLTL 206
E+ Q Q + +++E+ LQ TL
Sbjct: 969 METSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1005
Score = 40.4 bits (93), Expect = 0.001
Identities = 42/195 (21%), Positives = 86/195 (44%), Gaps = 23/195 (11%)
Query: 8 LQQLQEELQNKSQQLRAWEAEKYNEIRTQ-EQNIQHLNHSLSHKEQLLQEFRELLQYRDN 66
LQ+ E++ K++Q + A+K+ E + + E+ + L + QE + +Y
Sbjct: 929 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKA--RYERA 986
Query: 67 SDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLA---------- 116
+ +T +E +L+ L++ + D L+ A +E L+E E+ +Q A
Sbjct: 987 TSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAM 1046
Query: 117 ------VRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEME 170
+E+ L L D +N +++L VE+L+ + + L ++ME
Sbjct: 1047 QIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKME 1106
Query: 171 TKFSRWQKEQESIIQ 185
++KE E++ Q
Sbjct: 1107 ----EFRKEIETLKQ 1117
Score = 39.7 bits (91), Expect = 0.002
Identities = 47/232 (20%), Positives = 101/232 (43%), Gaps = 30/232 (12%)
Query: 1 MEELRKALQQLQEE---LQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 57
M+E L Q +E+ L + ++LR A+ + R +++ + L + KE+L +
Sbjct: 828 MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQL---IKAKEKLENDI 884
Query: 58 RELLQYR-DNSDKTLEANEMLLEKLRQ---------RIRDKAVALERAIDEKFSALEEKE 107
E+++ DNS + + N+ L K R + + A L+++I++ E+ +
Sbjct: 885 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ 944
Query: 108 KELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTC-------- 159
+E A ++ + + + L LS E M+T + + E+ ++
Sbjct: 945 QE------AAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEIL 998
Query: 160 QNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLRQLVQ 211
QNLQ + E K ++E ++Q+L+ +K A+ Q+++
Sbjct: 999 QNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIME 1050
Score = 37.0 bits (84), Expect = 0.012
Identities = 45/206 (21%), Positives = 84/206 (40%), Gaps = 30/206 (14%)
Query: 11 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKT 70
LQE L+ K Q + AE+ + + + SH ++ QE L RD D+
Sbjct: 353 LQEALKEKQQHIEQLLAER-------DLERAEVAKATSHVGEIEQE---LALARDGHDQH 402
Query: 71 LEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDV 130
+ E +++LR + A +R E + LEE+++++ L+ V E L
Sbjct: 403 VLELEAKMDQLRTMVE----AADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVA 458
Query: 131 LSSNEATMQTMESLLRAKGLEVEQLS----------------TTCQNLQWLKEEMETKFS 174
S ++ + +E L + EV +L + Q + L+E++E +
Sbjct: 459 TVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRT 518
Query: 175 RWQKEQESIIQQLQTSLHDRNKEVEA 200
Q+E S+ + KE++A
Sbjct: 519 DHQREITSLKEHFGAREETHQKEIKA 544
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 55.5 bits (132), Expect = 3e-08
Identities = 50/206 (24%), Positives = 96/206 (46%), Gaps = 21/206 (10%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAE-KYNEIR--TQEQNIQHLNHSLSHKEQLLQEF 57
++ LRKA + + E++ QQL A E + K+ EI + + L +E L
Sbjct: 765 LDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNL 824
Query: 58 RELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAV 117
+E L +TLE +L++ ++AV+++R++ E + L +KE++ L
Sbjct: 825 QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNML---- 880
Query: 118 RERDHDLERLRDVLSSNEATM----QTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKF 173
DLE+LR+ L+ EA + E L++AK E+L + + + ++
Sbjct: 881 ---SSDLEKLRENLADMEAKFREKDEREEQLIKAK----EKLENDIAEIMKMSGDNSSQL 933
Query: 174 SRWQKE---QESIIQQLQTSLHDRNK 196
++ E +E +++LQ L N+
Sbjct: 934 TKMNDELRLKERDVEELQLKLTKANE 959
Score = 52.8 bits (125), Expect = 2e-07
Identities = 54/213 (25%), Positives = 106/213 (49%), Gaps = 26/213 (12%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
MEE RK ++ L++ KSQQL A + E ++ E+ + + SH Q L+E R +
Sbjct: 1140 MEEFRKEIETLKQAAAQKSQQLSALQEE---NVKLAEELGRSRDEVTSH--QKLEEERSV 1194
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLR---LAV 117
L +++ LE + + ++ +KA +L+++I + L EK+ EL +LR +
Sbjct: 1195 L-----NNQLLEMKKRESKFIKDADEEKA-SLQKSISITSALLTEKDAELEKLRNEVTVL 1248
Query: 118 RERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVE------QLSTTCQNLQWLKEEMET 171
R + + L V+ + E+ +E L+ K LE++ QLS++ N +E E
Sbjct: 1249 RGENASAKSLHSVVQTLESDKVKLE--LKVKNLELQLKENKRQLSSSSGNTDTQADEDE- 1305
Query: 172 KFSRWQKEQESIIQQLQTSLHDRNKEVEARLQL 204
R Q+ Q + + L +N++++ ++++
Sbjct: 1306 ---RAQESQIDFLNSVIVDLQRKNQDLKMKVEM 1335
Score = 45.8 bits (107), Expect = 3e-05
Identities = 44/193 (22%), Positives = 88/193 (45%), Gaps = 6/193 (3%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQN-IQHLNHSLSHKEQLLQ--EF 57
+E++R Q E LQN+ RA A++ +R + I+ +SL L E
Sbjct: 652 IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED 711
Query: 58 RELLQYRDNSDKTLEANEML--LEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRL 115
+ L++ D +K EA + LE L+ + ++ ++ + A EEK +L LR
Sbjct: 712 QHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDN-FTSQLKATEEKLLDLDALRK 770
Query: 116 AVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSR 175
A E ++++LR L + E ++ +E A+ + ++ Q + ++ S
Sbjct: 771 ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSE 830
Query: 176 WQKEQESIIQQLQ 188
+ +E++ ++LQ
Sbjct: 831 VSQVKETLEKELQ 843
Score = 40.4 bits (93), Expect = 0.001
Identities = 42/217 (19%), Positives = 92/217 (42%), Gaps = 11/217 (5%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
++E + Q++E L+ + Q L+ AE E + ++++Q + L KE+
Sbjct: 824 LQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSD 883
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
L+ + +EA ++ +++ LE I E + +L ++ +R +
Sbjct: 884 LEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK 943
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQ-LSTTCQNLQWLKEEMETKFSRWQKE 179
+ D+E L+ L+ ++ + ++ EQ + + K+E+E K S +K+
Sbjct: 944 ERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKK 1003
Query: 180 QESIIQQLQ----------TSLHDRNKEVEARLQLTL 206
E+ Q Q + +++E+ LQ TL
Sbjct: 1004 METSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1040
Score = 40.4 bits (93), Expect = 0.001
Identities = 42/195 (21%), Positives = 86/195 (44%), Gaps = 23/195 (11%)
Query: 8 LQQLQEELQNKSQQLRAWEAEKYNEIRTQ-EQNIQHLNHSLSHKEQLLQEFRELLQYRDN 66
LQ+ E++ K++Q + A+K+ E + + E+ + L + QE + +Y
Sbjct: 964 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKA--RYERA 1021
Query: 67 SDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLA---------- 116
+ +T +E +L+ L++ + D L+ A +E L+E E+ +Q A
Sbjct: 1022 TSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAM 1081
Query: 117 ------VRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEME 170
+E+ L L D +N +++L VE+L+ + + L ++ME
Sbjct: 1082 QIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKME 1141
Query: 171 TKFSRWQKEQESIIQ 185
++KE E++ Q
Sbjct: 1142 ----EFRKEIETLKQ 1152
Score = 39.7 bits (91), Expect = 0.002
Identities = 47/232 (20%), Positives = 101/232 (43%), Gaps = 30/232 (12%)
Query: 1 MEELRKALQQLQEE---LQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 57
M+E L Q +E+ L + ++LR A+ + R +++ + L + KE+L +
Sbjct: 863 MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQL---IKAKEKLENDI 919
Query: 58 RELLQYR-DNSDKTLEANEMLLEKLRQ---------RIRDKAVALERAIDEKFSALEEKE 107
E+++ DNS + + N+ L K R + + A L+++I++ E+ +
Sbjct: 920 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ 979
Query: 108 KELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTC-------- 159
+E A ++ + + + L LS E M+T + + E+ ++
Sbjct: 980 QE------AAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEIL 1033
Query: 160 QNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLRQLVQ 211
QNLQ + E K ++E ++Q+L+ +K A+ Q+++
Sbjct: 1034 QNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIME 1085
Score = 32.7 bits (73), Expect = 0.23
Identities = 46/228 (20%), Positives = 92/228 (40%), Gaps = 29/228 (12%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQ-----HLNHSLSHKEQLLQ 55
++E K QQ E+L + RA A+ + + EQ + H H L E +
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLE-LEAKMD 411
Query: 56 EFRELLQYRDNSD----KTLEANEMLLEKLRQRIRDKAVA---LERAIDEKFSALEEKEK 108
+ R +++ D LE + +E L+ R+ ++++ LE + + ++E E+
Sbjct: 412 QLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQ 471
Query: 109 ELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLS------------ 156
L + + +LE R S ++ + +E L + EV +L
Sbjct: 472 SLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDV 531
Query: 157 ----TTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEA 200
+ Q + L+E++E + Q+E S+ + KE++A
Sbjct: 532 DMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKA 579
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 55.5 bits (132), Expect = 3e-08
Identities = 54/213 (25%), Positives = 105/213 (49%), Gaps = 19/213 (8%)
Query: 9 QQLQEELQNKSQQLRAWEAEKYN---EIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD 65
Q+LQ+ L+N +++++ E+E + E +T ++N++ L S EQL +E + L +
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSL----E 821
Query: 66 NSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLE 125
LE ++ LEK +R+R +A + ++E + EKE + L +
Sbjct: 822 QETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCV 881
Query: 126 RLRDVLSSNE-----ATMQTMESLLRAKGLEVEQLSTTCQN--LQWLKEEMETKFSRWQK 178
RL+++ N+ AT+ + + L E+L T N L+ L E+E +
Sbjct: 882 RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELE----KIGL 937
Query: 179 EQESIIQQLQTSLHDRNKEVEARLQLTLRQLVQ 211
+E ++ Q S DR K +E++L+ TL++ ++
Sbjct: 938 NKERLLHDEQ-STDDRYKLLESKLESTLKKSLE 969
Score = 51.6 bits (122), Expect = 5e-07
Identities = 52/215 (24%), Positives = 99/215 (46%), Gaps = 15/215 (6%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHL---NHSLSH-------- 49
+E K +QQL+ ELQ+ + + + + E++ + ++ L N SL
Sbjct: 772 LENSNKKIQQLESELQDLEMENQTLQ-KNLEELKISSKRLEQLEKENKSLEQETSQLEKD 830
Query: 50 KEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAI-DEKFSALEEKEK 108
K+QL +E + L Q + D TLE N + + L + +K ++ E I E L+E EK
Sbjct: 831 KKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE--NKTLSKEIGIYKESCVRLKELEK 888
Query: 109 ELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEE 168
E ++L L LR+ L S + Q M + L E+E++ + L ++
Sbjct: 889 ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS 948
Query: 169 METKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQ 203
+ ++ + + ES +++ ++ +EARL+
Sbjct: 949 TDDRYKLLESKLESTLKKSLEIKEEKIAALEARLE 983
Score = 43.9 bits (102), Expect = 1e-04
Identities = 47/221 (21%), Positives = 103/221 (46%), Gaps = 34/221 (15%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEK---------YNEIRTQEQNIQHLNHSLSHKE 51
++++ K + L E ++ S +L E EK Y E + + +++ H L +
Sbjct: 582 VKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKEN 641
Query: 52 QLLQE-------FRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALE 104
+LLQ+ E ++ + + LE L+K ++ LE +++++ S L+
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLE-SLEKENSQLD 700
Query: 105 EKEKELR--------------QLRLAVRERDHDLERLRDVLSSNEATMQTMESL-LRAKG 149
E+ ELR QL+L +E + + E+L+ L +A+ + E L + +G
Sbjct: 701 EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760
Query: 150 LEVE--QLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQ 188
L++E +L T +N +++E++ + E +++ + L+
Sbjct: 761 LDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801
Score = 41.2 bits (95), Expect = 6e-04
Identities = 52/210 (24%), Positives = 97/210 (46%), Gaps = 24/210 (11%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
EE AL+ EE N +QQLR E++T ++N + L E+ + + +
Sbjct: 972 EEKIAALEARLEESTNYNQQLR-------QELKTVKKNYEALKQR--QDEERMVQSSPPI 1022
Query: 62 QYRDNSDKTLEANEMLLEKLRQRIRDKAVALER---AIDEKFSALEEKEKELRQLRLAVR 118
DN + E+ E E L+ ++D+ + +ER + + AL+ + K+L ++
Sbjct: 1023 SGEDNKWER-ESQETTRELLK--VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 1079
Query: 119 ERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTC--QNLQWLKEEMETKFSRW 176
+ L+R L T+QT + L+ + + ST+ QN Q L ++ S
Sbjct: 1080 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQ-----SSL 1134
Query: 177 QKEQESIIQQLQ--TSLHDRNKEVEARLQL 204
+ E ES+I++ + SL+D + +L+L
Sbjct: 1135 ENENESVIKEREDLKSLYDSLIKDHEKLEL 1164
Score = 40.0 bits (92), Expect = 0.001
Identities = 51/222 (22%), Positives = 92/222 (41%), Gaps = 17/222 (7%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
+E L K QL EE + +LR E + +Q N L +++ L++ EL
Sbjct: 689 LESLEKENSQLDEE----NLELRR-NVESLKCASMKMAQLQLENKELESEKEQLKKGLEL 743
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
L+ + LE + L+ QR++ + I + S L++ E E + L+ + E
Sbjct: 744 LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL 803
Query: 121 DHDLERLRDVLSSNEATMQTMESLLR-AKGLEVE--QLSTTCQNLQWLKEEMETKFSRWQ 177
+RL + N++ Q L + K LE E +L + EE K +
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863
Query: 178 KEQESIIQQL---------QTSLHDRNKEVEARLQLTLRQLV 210
KE +++ +++ L NKE+ R + ++ LV
Sbjct: 864 KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905
Score = 38.9 bits (89), Expect = 0.003
Identities = 39/199 (19%), Positives = 87/199 (43%), Gaps = 21/199 (10%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
+E ++L + EEL+ + ++I E+ Q L+ + E + + ++
Sbjct: 465 LEMENQSLTKTVEELRTTVDSVEG----NASKILKMEKENQRLSKKVEILENEIVQEKQS 520
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
LQ N K L + LEK + +R+ + + + LE++ + L Q ++R+R
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENS-------ERQIKILEQENEHLNQTVSSLRQR 573
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ 180
S EA ++ +E + +++ S+ +++ K +++ + + KE+
Sbjct: 574 SQ---------ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY-KEK 623
Query: 181 ESIIQQLQTSLHDRNKEVE 199
++L+ LH KE E
Sbjct: 624 GERAEELENELHHLEKENE 642
Score = 34.3 bits (77), Expect = 0.079
Identities = 46/245 (18%), Positives = 110/245 (44%), Gaps = 43/245 (17%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEA--EKYNEIRTQEQNIQHLNHSLSHKEQLLQEFR 58
+E++ L++LQ+E N R+ ++ + +R + + L +S ++ L +
Sbjct: 281 LEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIE 340
Query: 59 ELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELR-QLRLAV 117
Y+ ++ E N++LLE + + + + RA +K LE++ +L+ +L
Sbjct: 341 F---YKARVEELKEDNQVLLET--KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDME 395
Query: 118 RERDHDLERLRDVLSSNE----ATMQTMESLL--------------------RAKGLEVE 153
ERD D +++ +++ N A Q+M+ L ++ G EV
Sbjct: 396 MERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVN 455
Query: 154 QLSTTCQNLQWLKEEMETK-FSRWQKEQESIIQQLQ------TSLHDRNKEVEARLQLTL 206
+L+++ + LK EME + ++ +E + + ++ + N+ + ++++
Sbjct: 456 ELTSS----RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILE 511
Query: 207 RQLVQ 211
++VQ
Sbjct: 512 NEIVQ 516
Score = 28.9 bits (63), Expect = 3.3
Identities = 44/222 (19%), Positives = 97/222 (43%), Gaps = 23/222 (10%)
Query: 5 RKALQQLQEEL---QNKSQQLRAWEAEKYNEIRTQEQNIQ--HLNHSLSHKEQLLQEFRE 59
R+ L+ L + L K + L +A +Y + ++ ++ H N + H++ L + +
Sbjct: 1145 REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRD-LEDRYNQ 1203
Query: 60 LLQYR---DNSDKTL--EANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLR 114
LL+ + ++ +K L E +MLLE + + A + + + L +L +
Sbjct: 1204 LLKQKGQLEDLEKMLKVEQEKMLLEN---KNHETVAAEYKKLCGENDRLNHTYSQLLK-E 1259
Query: 115 LAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS 174
V + DH + L+ +L++++ +E+ + +QL T L E +
Sbjct: 1260 TEVLQTDH--KNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG 1317
Query: 175 RWQKEQESIIQQLQT------SLHDRNKEVEARLQLTLRQLV 210
++E ++ Q+QT +L ++N E + + RQ +
Sbjct: 1318 NLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYI 1359
>gi|38348729 hypothetical protein LOC203238 [Homo sapiens]
Length = 1326
Score = 55.5 bits (132), Expect = 3e-08
Identities = 53/216 (24%), Positives = 102/216 (47%), Gaps = 15/216 (6%)
Query: 2 EELRKALQQLQEEL--QNKSQQLRAWEAEKYNEIRTQE--QNIQHLNHSLSHKEQLLQ-- 55
EE ++QE+L QN Q + E EK + Q+ + + H L ++ ++Q
Sbjct: 103 EERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNC 162
Query: 56 --EFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQL 113
E+ L++ + +KTL+ E L + R++ ++ E A++E E+ E E R+L
Sbjct: 163 NREYDLLMKEKSRLEKTLQ--EALEKHQREKNEMESHIRETALEEFRLQEEQWEAERREL 220
Query: 114 RLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKF 173
+ V+E+D ++ + + E LLR + +L + Q + L++E E
Sbjct: 221 QFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRR---QTSELEFSTQREERLRKEFEATT 277
Query: 174 SRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLRQL 209
R +K +E+I + + + H +K +QL +R L
Sbjct: 278 LRVRKLEENI--EAERAAHLESKFNSEIIQLRIRDL 311
Score = 33.9 bits (76), Expect = 0.10
Identities = 40/155 (25%), Positives = 72/155 (46%), Gaps = 14/155 (9%)
Query: 2 EELRKAL---QQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFR 58
EEL AL +Q Q L ++QQL+ E E+ + E+ + N +L + L E +
Sbjct: 1040 EELNNALLREEQAQMLLNEQAQQLQ--ELNYKLELHSSEEADK--NQTLGEAVKSLSEAK 1095
Query: 59 ELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVR 118
L+ +D S + L + LE+ ++R LE I + SAL K+ + +R
Sbjct: 1096 MELRRKDQSLRQLNRHLTQLEQDKRR-------LEENIHDAESALRMAAKDKECVANHMR 1148
Query: 119 ERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVE 153
++ L ++RD +S + + + L+ L +E
Sbjct: 1149 AVENTLHKVRDQISLSWSAASRNDFTLQLPKLHLE 1183
Score = 32.3 bits (72), Expect = 0.30
Identities = 53/209 (25%), Positives = 87/209 (41%), Gaps = 37/209 (17%)
Query: 9 QQLQEELQNKSQQLRAWE-AEKYNEIRTQEQNIQHLNHSLSHKEQLLQE---FRELLQYR 64
Q+ + ELQ L + A+K+ EI E+N++ LNH EQL+ E F++LL
Sbjct: 663 QKKELELQYSELFLEVQKRAQKFQEIA--EKNMEKLNHIEKSHEQLVLENSHFKKLLSQT 720
Query: 65 DNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL 124
+L A L+ + ++ AL D L+E+ +L +R L
Sbjct: 721 QREQMSLLAACALMAGALYPLYSRSCALSTQRD----FLQEQVNTFELFKLEIRTLAQAL 776
Query: 125 ERLRDVLSSNEATM--QTMESLLR--AKGL-------EVEQLSTTCQNL-QWLKEEME-- 170
+ + EA M +T + L+R KG+ ++ L +C +L W++ E
Sbjct: 777 STVEE-KKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGI 835
Query: 171 ------------TKFSRWQKEQESIIQQL 187
KF + QKEQ +Q L
Sbjct: 836 GMLVCTGEPQDKHKFPKHQKEQLRCLQAL 864
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 54.7 bits (130), Expect = 6e-08
Identities = 43/204 (21%), Positives = 94/204 (46%), Gaps = 17/204 (8%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
EELR L ++EL+ L A + +E+ QHL +Q +QE E L
Sbjct: 900 EELRARLTAKKQELEEICHDLEA-------RVEEEEERCQHLQAEKKKMQQNIQELEEQL 952
Query: 62 QYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEK---EKELRQLRLAVR 118
+ +++ + L+ ++ E +++ ++ + LE D+ +EK E + + +
Sbjct: 953 EEEESARQKLQLEKVTTEAKLKKLEEEQIILE---DQNCKLAKEKKLLEDRIAEFTTNLT 1009
Query: 119 ERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQK 178
E + + L + + +EA + +E LR + + ++L T + L+ ++ + + Q
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 179 EQESIIQQLQTSLHDRNKEVEARL 202
+ I +L+ L + +E++A L
Sbjct: 1070 Q----IAELKMQLAKKEEELQAAL 1089
Score = 50.4 bits (119), Expect = 1e-06
Identities = 40/194 (20%), Positives = 87/194 (44%), Gaps = 4/194 (2%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
+EL + L+ ++ + ++ + +AEK + +QNIQ L L +E Q+ +
Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEK----KKMQQNIQELEEQLEEEESARQKLQLEK 966
Query: 62 QYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 121
+ K LE +++LE ++ + LE I E + L E+E++ + L + +
Sbjct: 967 VTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHE 1026
Query: 122 HDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 181
+ L + L E Q +E R + LS LQ E++ + ++ ++E +
Sbjct: 1027 AMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQ 1086
Query: 182 SIIQQLQTSLHDRN 195
+ + +++ +N
Sbjct: 1087 AALARVEEEAAQKN 1100
Score = 46.6 bits (109), Expect = 2e-05
Identities = 50/217 (23%), Positives = 95/217 (43%), Gaps = 18/217 (8%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
+EE + L+ +L + + L AE + +E+ + L + E ++ + E
Sbjct: 976 LEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEER 1035
Query: 61 LQYRDNSDKTLEANEMLLE-----------KLRQRIRDKAVALERAIDEKFSALEEKEKE 109
L+ + + LE LE +L+ +I + + L + +E +AL E+E
Sbjct: 1036 LRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEE 1095
Query: 110 LRQLRLA---VRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLK 166
Q +A +RE + + L++ L S A+ E R G E+E L T ++ L
Sbjct: 1096 AAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDT--LD 1153
Query: 167 EEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQ 203
+ R ++EQE + L+ +L + K EA++Q
Sbjct: 1154 STAAQQELRSKREQE--VNILKKTLEEEAKTHEAQIQ 1188
Score = 43.9 bits (102), Expect = 1e-04
Identities = 48/217 (22%), Positives = 99/217 (45%), Gaps = 30/217 (13%)
Query: 1 MEELRKALQQLQEELQNKSQ-------QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQL 53
+EE++ L++L++ELQ L+A +A+ +++ +++ S K+QL
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQ------SEEKKKQL 1587
Query: 54 LQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQL 113
+++ RE+ ++ K +KL ++D LE ID +E K+LR+L
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKD----LEAHIDSANKNRDEAIKQLRKL 1643
Query: 114 RLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEM---E 170
+ +++ +L+ R S E Q E+ + K +E E + L+EE+ E
Sbjct: 1644 QAQMKDCMRELDDTR--ASREEILAQAKENEKKLKSMEAEMIQ--------LQEELAAAE 1693
Query: 171 TKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLR 207
+ Q+E++ + ++ S +E + +L R
Sbjct: 1694 RAKRQAQQERDELADEIANSSGKGALALEEKRRLEAR 1730
Score = 41.6 bits (96), Expect = 5e-04
Identities = 52/250 (20%), Positives = 103/250 (41%), Gaps = 42/250 (16%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKE-QLLQEFREL 60
EE + Q+QE Q SQ + AE+ + + + N++ +L ++ +L E + L
Sbjct: 1178 EEAKTHEAQIQEMRQKHSQAVEEL-AEQLEQTKRVKANLEKAKQTLENERGELANEVKVL 1236
Query: 61 LQYRDNSD---KTLEANEMLL-------EKLRQRIRDKAVALERAID------------- 97
LQ + +S+ K +EA L E++R + DK L+ +D
Sbjct: 1237 LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKS 1296
Query: 98 ----EKFSALE-----------EKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTME 142
+ FSALE E+ ++ L +++ + + R+ L E +E
Sbjct: 1297 SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE 1356
Query: 143 SLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQ--QLQTSLHDRNKEVEA 200
+ +V + ++ E E + QK+ E + Q + + + +D+ ++ +
Sbjct: 1357 KQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKT 1416
Query: 201 RLQLTLRQLV 210
RLQ L L+
Sbjct: 1417 RLQQELDDLL 1426
Score = 38.9 bits (89), Expect = 0.003
Identities = 56/233 (24%), Positives = 99/233 (42%), Gaps = 31/233 (13%)
Query: 4 LRKALQQLQEELQNKSQQ-------LRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ- 55
L LQ QE LQ +++Q L+ E EK N R Q + + H+L + L
Sbjct: 1306 LESQLQDTQELLQEENRQKLSLSTKLKQVEDEK-NSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 56 EFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRL 115
+ ++ + ++S LE E + KL++ + L + +EK +A ++ EK +L+
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLE----GLSQRHEEKVAAYDKLEKTKTRLQQ 1420
Query: 116 AVRERDHDLERLRDVLSSNEATMQTMESLL---------------RAKGLEVEQLSTTCQ 160
+ + DL+ R + E + + LL RA+ E+ +
Sbjct: 1421 ELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALS 1480
Query: 161 NLQWLKEEMETK--FSRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLRQLVQ 211
+ L+E ME K R K+ + ++ L +S D K V L+ + R L Q
Sbjct: 1481 LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVH-ELEKSKRALEQ 1532
Score = 37.4 bits (85), Expect = 0.009
Identities = 36/143 (25%), Positives = 68/143 (47%), Gaps = 14/143 (9%)
Query: 52 QLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKF---SALEEKEK 108
+L + + LLQ ++ + E L+ ++R+K +A E + E S L ++
Sbjct: 829 RLFTKVKPLLQVSRQEEEMMAKEEELV-----KVREKQLAAENRLTEMETLQSQLMAEKL 883
Query: 109 ELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEE 168
+L++ A E + E LR L++ + Q +E + VE+ CQ+LQ K++
Sbjct: 884 QLQEQLQAETELCAEAEELRARLTAKK---QELEEICHDLEARVEEEEERCQHLQAEKKK 940
Query: 169 METKFSRWQ---KEQESIIQQLQ 188
M+ + +E+ES Q+LQ
Sbjct: 941 MQQNIQELEEQLEEEESARQKLQ 963
Score = 36.6 bits (83), Expect = 0.016
Identities = 45/218 (20%), Positives = 93/218 (42%), Gaps = 24/218 (11%)
Query: 4 LRKALQQLQE---ELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSL-SHKEQLLQEFRE 59
L +AL++ E EL+ ++Q R + ++ + + ++ H L K L Q+ E
Sbjct: 1481 LARALEEAMEQKAELERLNKQFRT----EMEDLMSSKDDVGKSVHELEKSKRALEQQVEE 1536
Query: 60 LLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRE 119
+ + + L+A E +L ++ ER + + EEK+K QL VRE
Sbjct: 1537 MKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKK---QLVRQVRE 1593
Query: 120 RDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKE 179
+ +LE R S A + +E ++++ L + ++E + + Q +
Sbjct: 1594 MEAELEDERKQRSMAVAARKKLE-------MDLKDLEAHIDSANKNRDEAIKQLRKLQAQ 1646
Query: 180 QESIIQQLQTSLHDRN------KEVEARLQLTLRQLVQ 211
+ +++L + R KE E +L+ +++Q
Sbjct: 1647 MKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684
Score = 36.2 bits (82), Expect = 0.021
Identities = 38/207 (18%), Positives = 91/207 (43%), Gaps = 14/207 (6%)
Query: 3 ELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 62
E + L++L ++ + + + L + + + + E++ + L + + L+E + LQ
Sbjct: 1490 EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ 1549
Query: 63 YRDNSDKTLEAN--------EMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLR 114
+++ LE N E L+ ++ +K L R + E + LE++ K+ R +
Sbjct: 1550 ATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ-RSMA 1608
Query: 115 LAVRER-DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKF 173
+A R++ + DL+ L + S LR +++ + + +EE+ +
Sbjct: 1609 VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ- 1667
Query: 174 SRWQKEQESIIQQLQTSLHDRNKEVEA 200
KE E ++ ++ + +E+ A
Sbjct: 1668 ---AKENEKKLKSMEAEMIQLQEELAA 1691
Score = 33.5 bits (75), Expect = 0.14
Identities = 41/211 (19%), Positives = 91/211 (43%), Gaps = 12/211 (5%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
EEL K +++ Q +N+ ++ +++ E ++ +Q + E+L
Sbjct: 852 EELVK-VREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKK 910
Query: 62 QYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 121
Q + LEA E+ Q ++ + +++ I E LEE+E ++L+L +
Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE 970
Query: 122 HDLERLRD---VLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQK 178
L++L + +L + + LL + + + +T +EE ++ +
Sbjct: 971 AKLKKLEEEQIILEDQNCKLAKEKKLLEDR---IAEFTTNLTE----EEEKSKSLAKLKN 1023
Query: 179 EQESIIQQLQTSLHDRNKEVEARLQLTLRQL 209
+ E++I L+ L R ++ L+ T R+L
Sbjct: 1024 KHEAMITDLEERLR-REEKQRQELEKTRRKL 1053
Score = 32.0 bits (71), Expect = 0.39
Identities = 28/146 (19%), Positives = 63/146 (43%), Gaps = 1/146 (0%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYN-EIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
E R+ L++ +EL+ K Q++ KY I E I L L ++ + Q +
Sbjct: 1777 ENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQ 1836
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
++ + K + + ++ +D+A + + LEE E+E ++ + R+
Sbjct: 1837 VRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKL 1896
Query: 121 DHDLERLRDVLSSNEATMQTMESLLR 146
+LE + + + ++++ LR
Sbjct: 1897 QRELEDATETADAMNREVSSLKNKLR 1922
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 54.7 bits (130), Expect = 6e-08
Identities = 40/210 (19%), Positives = 101/210 (48%), Gaps = 15/210 (7%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
+ E ++ ++ Q EL++ ++ R+ E + E++++HL + L +E +L
Sbjct: 1453 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDL 1512
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
+ +S KT+ LEK+R+++ + + L+ A++E ++LE +E ++ + +L +
Sbjct: 1513 TEQLGSSGKTIHE----LEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQI 1568
Query: 121 DHDLER--------LRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETK 172
++ER + ++ + ++++ L A+ + + ++ EME +
Sbjct: 1569 KAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQ 1628
Query: 173 FS---RWQKEQESIIQQLQTSLHDRNKEVE 199
S R E + ++ LQ+ L D +++
Sbjct: 1629 LSHANRMAAEAQKQVKSLQSLLKDTQIQLD 1658
Score = 50.4 bits (119), Expect = 1e-06
Identities = 43/205 (20%), Positives = 94/205 (45%), Gaps = 8/205 (3%)
Query: 5 RKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLL----QEFREL 60
++ L+ EL+ L A+ E E +++L ++ ++++ +E + L
Sbjct: 940 KRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL 999
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
+ + L+A E +K+ + K V LE+ +D+ +LE+++K L A R+
Sbjct: 1000 QEAHQQALDDLQAEE---DKVNTLTKAK-VKLEQQVDDLEGSLEQEKKVRMDLERAKRKL 1055
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ 180
+ DL+ ++ + E Q ++ L+ K E+ L+ ++ Q L +++ K Q
Sbjct: 1056 EGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARI 1115
Query: 181 ESIIQQLQTSLHDRNKEVEARLQLT 205
E + ++L+ R K + R L+
Sbjct: 1116 EELEEELEAERTARAKVEKLRSDLS 1140
Score = 46.6 bits (109), Expect = 2e-05
Identities = 43/209 (20%), Positives = 99/209 (47%), Gaps = 18/209 (8%)
Query: 1 MEELRKALQQLQ-------EELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQL 53
+EELR ++Q + +EL S++++ ++ + I +++ L+ + E+
Sbjct: 1685 LEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEA 1744
Query: 54 LQEFRELLQYRDNS--DKTLEANEML--------LEKLRQRIRDKAVALERAIDEKFS-A 102
+QE R + + D + A E+ LE++++ + L+ +DE A
Sbjct: 1745 VQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA 1804
Query: 103 LEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNL 162
L+ +K+L++L VRE +++LE + + + M+ E ++ + E+ L
Sbjct: 1805 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRL 1864
Query: 163 QWLKEEMETKFSRWQKEQESIIQQLQTSL 191
Q L ++++ K ++++ E +Q T+L
Sbjct: 1865 QDLVDKLQLKVKAYKRQAEEAEEQANTNL 1893
Score = 45.1 bits (105), Expect = 4e-05
Identities = 44/199 (22%), Positives = 97/199 (48%), Gaps = 17/199 (8%)
Query: 1 MEELRKALQQLQEELQN------KSQQLRA---WEAEKYNEIRTQEQNIQHLNHSLSHKE 51
++EL+ +++L+EEL+ K ++LR+ E E+ +E + + ++ K
Sbjct: 1108 LKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR 1167
Query: 52 QLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELR 111
+ EF+++ RD + TL+ +E LR++ D L ID ++ EKE
Sbjct: 1168 EA--EFQKMR--RDLEEATLQ-HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1222
Query: 112 QLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 171
+ +L + + ++E++ ++ E +T+E + + E+ + +L + +++T
Sbjct: 1223 EFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT 1282
Query: 172 ---KFSRWQKEQESIIQQL 187
+ SR E+E++I QL
Sbjct: 1283 ENGELSRQLDEKEALISQL 1301
Score = 42.7 bits (99), Expect = 2e-04
Identities = 49/189 (25%), Positives = 83/189 (43%), Gaps = 23/189 (12%)
Query: 3 ELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 62
+L QQL E L+ K +L A A +E Q L L K + LQ E L+
Sbjct: 1068 DLENDKQQLDERLKKKDFELNALNARIEDE--------QALGSQLQKKLKELQARIEELE 1119
Query: 63 YRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDH 122
+++T A +EKLR L R ++E LEE ++R+
Sbjct: 1120 EELEAERTARAK---VEKLRSD-------LSRELEEISERLEEAGGATSVQIEMNKKREA 1169
Query: 123 DLERLRDVLSSNEATMQ---TMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKE 179
+ +++R L EAT+Q T +L + V +L NLQ +K+++E + S ++ E
Sbjct: 1170 EFQKMRRDLE--EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1227
Query: 180 QESIIQQLQ 188
+ + ++
Sbjct: 1228 LDDVTSNME 1236
Score = 41.6 bits (96), Expect = 5e-04
Identities = 42/212 (19%), Positives = 97/212 (45%), Gaps = 9/212 (4%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
++L +QL+EE++ K+ A ++ +++ +EQ + + L + E+
Sbjct: 1310 QQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1369
Query: 62 QYRDNSD----KTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAV 117
Q+R + + E E +KL QR+++ A+E A++ K S+L EK +L+ +
Sbjct: 1370 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVE-AVNAKCSSL---EKTKHRLQNEI 1425
Query: 118 RERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 177
+ D+ER ++ + + + +L + E+ + ++ Q + T+ + +
Sbjct: 1426 EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1485
Query: 178 KEQESIIQQLQTSLHDRNKEVEARLQLTLRQL 209
E ++ L+T + NK ++ + QL
Sbjct: 1486 NAYEESLEHLETFKRE-NKNLQEEISDLTEQL 1516
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 54.3 bits (129), Expect = 7e-08
Identities = 45/205 (21%), Positives = 102/205 (49%), Gaps = 8/205 (3%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
+ELR+ + ++E Q + Q+ + WE E+ ++R QE+ + L +E+ ++E + +
Sbjct: 297 KELREQKKLREQEEQMQEQEEKMWEQEE--KMREQEEKMWRQEERLWEQEKQMREQEQKM 354
Query: 62 QYRDNSDKTLEANEMLLEKL-RQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
RD ++ E +E L EK R R ++K E + E+ + E+EK++R+ +RE+
Sbjct: 355 --RDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEE-ERIREREKKMREEEETMREQ 411
Query: 121 DHDLERLRDVLSSNEATMQTMESL--LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQK 178
+ +++ + + E + L + K E E++ + + +E++ + W +
Sbjct: 412 EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ 471
Query: 179 EQESIIQQLQTSLHDRNKEVEARLQ 203
E++ Q+ D+ E E +++
Sbjct: 472 EKKMWRQEKMREQEDQMWEQEEKMR 496
Score = 52.0 bits (123), Expect = 4e-07
Identities = 36/190 (18%), Positives = 91/190 (47%), Gaps = 12/190 (6%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
M E K +++ +E ++ + ++++ E+ ++R QE+ + + +E+ + E E
Sbjct: 562 MREREKKMREEEEMMREQEEKMQ----EQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEK 617
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
+ ++ DK E EM+ E+ +K E + E+ + E+E+++R+ ++ +
Sbjct: 618 MWEQEEEDKMQEQEEMMWEQ-----EEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQ 672
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEV---EQLSTTCQNLQWLKEEMETKFSRWQ 177
+ + + + E M+ E +R + ++ E+ + W +EEM K R +
Sbjct: 673 EEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIR 732
Query: 178 KEQESIIQQL 187
++E + ++L
Sbjct: 733 DQKEKMQERL 742
Score = 45.1 bits (105), Expect = 4e-05
Identities = 43/211 (20%), Positives = 102/211 (48%), Gaps = 28/211 (13%)
Query: 1 MEELRKALQQLQEELQNKS----QQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQE 56
M+E + + + +E+++++ Q+ + W EK +R QE + + +EQ +
Sbjct: 448 MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEK---MREQEDQMWEQEEKMRDQEQKMW- 503
Query: 57 FRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVAL---ERAIDEKFSALEEK----EKE 109
D ++ E +E L EK +R+R++ E+ +EK + +EK ++E
Sbjct: 504 --------DQEERMWEQDERLREK-EERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEE 554
Query: 110 LRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEM 169
+ +RER+ + +++ E MQ E +R + E++ + +Q +E+M
Sbjct: 555 KMREEERMREREKKMREEEEMMREQEEKMQEQEEKMRE---QEEKMWEQEEKMQEQEEKM 611
Query: 170 -ETKFSRWQKEQESIIQQLQTSLHDRNKEVE 199
E + W++E+E +Q+ + + ++ ++++
Sbjct: 612 WEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQ 642
Score = 43.1 bits (100), Expect = 2e-04
Identities = 53/215 (24%), Positives = 99/215 (46%), Gaps = 34/215 (15%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQE----- 56
EEL+K +LQE+L R E+EK +EI+ N++ L L + LL +
Sbjct: 183 EELKKKNAELQEKL-------RLAESEK-SEIQL---NVKELKRKLERAKFLLPQVQTNT 231
Query: 57 -----FRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELR 111
+R+ + R+ +K + E + + +R+R++ E + E+ + +EK LR
Sbjct: 232 LQEEMWRQEEELREQ-EKKIRKQEEKMWRQEERLREQ----EGKMREQEEKMRRQEKRLR 286
Query: 112 QLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 171
+ +RE++ +L R + L E MQ E K E E+ + W +EE
Sbjct: 287 EQEKELREQEKEL-REQKKLREQEEQMQEQEE----KMWEQEEKMREQEEKMWRQEERLW 341
Query: 172 KFSRWQKEQESIIQQLQTSL---HDRNKEVEARLQ 203
+ + +EQE ++ + + +R +E E R++
Sbjct: 342 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMR 376
Score = 42.4 bits (98), Expect = 3e-04
Identities = 46/217 (21%), Positives = 96/217 (44%), Gaps = 40/217 (18%)
Query: 1 MEELRKALQQ---LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 57
++EL++ L++ L ++Q + Q W E+ E+R QE+ I+ + +E+ L+E
Sbjct: 210 VKELKRKLERAKFLLPQVQTNTLQEEMWRQEE--ELREQEKKIRKQEEKMWRQEERLREQ 267
Query: 58 RELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAV 117
++ ++ EK+R++ E+ + E+ L E+EKELR+ + +
Sbjct: 268 EGKMREQE-------------EKMRRQ--------EKRLREQEKELREQEKELREQK-KL 305
Query: 118 RERDHDLERLRDVLSSNEATMQTMESLL----------RAKGLEVEQLSTTCQNLQWLKE 167
RE++ ++ + + E M+ E + + E EQ + W ++
Sbjct: 306 REQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQD 365
Query: 168 EMETKFSRWQKEQESIIQQ---LQTSLHDRNKEVEAR 201
E + +EQE + +Q +Q R +E + R
Sbjct: 366 ERLREKEERMREQEKMWEQEEKMQEEERIREREKKMR 402
Score = 40.8 bits (94), Expect = 8e-04
Identities = 31/198 (15%), Positives = 92/198 (46%), Gaps = 8/198 (4%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
M E + +++ +E++Q + + + WE E E Q+Q + L +E++ ++ ++
Sbjct: 401 MREEEETMREQEEKMQKQEENM--WEQE---EKEWQQQRLPEQKEKLWEQEKMQEQEEKI 455
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
+ +K + EM ++ + ++K E + E+ + ++E+++ + E+
Sbjct: 456 WE---QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQ 512
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ 180
D L + + + Q E + K + ++ T Q + +EE + + +E+
Sbjct: 513 DERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 572
Query: 181 ESIIQQLQTSLHDRNKEV 198
E ++++ + + ++ +++
Sbjct: 573 EEMMREQEEKMQEQEEKM 590
Score = 40.4 bits (93), Expect = 0.001
Identities = 41/193 (21%), Positives = 84/193 (43%), Gaps = 17/193 (8%)
Query: 11 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDN---- 66
LQEE+ + ++LR E+ +IR QE+ + L +E ++E E ++ ++
Sbjct: 232 LQEEMWRQEEELR----EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLRE 287
Query: 67 SDKTLEANEMLL---EKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHD 123
+K L E L +KLR++ E+ +++ E++EK RQ + E++
Sbjct: 288 QEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQ-EERLWEQEKQ 346
Query: 124 LERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESI 183
+ + E M + LR K + + Q W +EE + R ++ ++ +
Sbjct: 347 MREQEQKMRDQEERMWEQDERLREKEERMRE-----QEKMWEQEEKMQEEERIREREKKM 401
Query: 184 IQQLQTSLHDRNK 196
++ +T K
Sbjct: 402 REEEETMREQEEK 414
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 54.3 bits (129), Expect = 7e-08
Identities = 52/220 (23%), Positives = 110/220 (50%), Gaps = 19/220 (8%)
Query: 1 MEELRKALQQLQEELQNKSQQL--RAWEAEKYNEIRTQ-EQNIQHLNHSLSHKEQLL--- 54
+E L +A ++L ++ + SQ+L +A +K + + + +Q + L L H+ Q+
Sbjct: 1387 IESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNL 1446
Query: 55 ----QEFRELL-QYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKE 109
++F +LL + + S + E + + R++ KA++L RA++E A EE E++
Sbjct: 1447 EKKQKKFDQLLAEEKSISARYAEERDRAEAEAREK-ETKALSLARALEEALEAKEEFERQ 1505
Query: 110 LRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEM 169
+QLR + DL +D + N + +E RA +VE++ T + L+ +
Sbjct: 1506 NKQLRADME----DLMSSKDDVGKN---VHELEKSKRALEQQVEEMRTQLEELEDELQAT 1558
Query: 170 ETKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLRQL 209
E R + +++ Q + L R+++ E + +L ++Q+
Sbjct: 1559 EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQV 1598
Score = 52.8 bits (125), Expect = 2e-07
Identities = 56/228 (24%), Positives = 104/228 (45%), Gaps = 22/228 (9%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
+++ ++ LQ+ + N S ++R E EK N ++ Q++ + +L + LQ +L
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEK-NSLQEQQEEEEEARKNLEKQVLALQS--QL 1373
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
+ D L E L E ++ ++D A AL + ++EK A ++ EK +L+ + +
Sbjct: 1374 ADTKKKVDDDLGTIESLEEAKKKLLKD-AEALSQRLEEKALAYDKLEKTKNRLQQELDDL 1432
Query: 121 DHDLERLRDVLSSNEATMQTMESLL---------------RAKGLEVEQLSTTCQNLQWL 165
DL+ R V S+ E + + LL RA+ E+ + + L
Sbjct: 1433 TVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARAL 1492
Query: 166 KEEMETK--FSRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLRQLVQ 211
+E +E K F R K+ + ++ L +S D K V L+ + R L Q
Sbjct: 1493 EEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVH-ELEKSKRALEQ 1539
Score = 50.4 bits (119), Expect = 1e-06
Identities = 53/217 (24%), Positives = 95/217 (43%), Gaps = 9/217 (4%)
Query: 2 EELRKALQQLQEELQNKSQQL--RAWEAEKYNEIRTQEQ-----NIQHLNHSLSHKEQLL 54
EE+R L ++EL+ L R E E+ N+I E+ +IQ L L +E
Sbjct: 907 EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR 966
Query: 55 QEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLR 114
Q+ + + K +E +LLE + + +E I E S L E+E++ + L
Sbjct: 967 QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026
Query: 115 LAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS 174
+++ + L + L E T Q +E R E L LQ +E++ + +
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA 1086
Query: 175 RWQKE-QESIIQQLQTSLHDRNK-EVEARLQLTLRQL 209
+ ++E Q ++ + +LH N +V LQ + +L
Sbjct: 1087 KKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123
Score = 48.9 bits (115), Expect = 3e-06
Identities = 51/218 (23%), Positives = 104/218 (47%), Gaps = 36/218 (16%)
Query: 1 MEELRKALQQLQEELQNKSQ-------QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQL 53
+EE+R L++L++ELQ ++A +A+ +++T+++ + K L
Sbjct: 1541 VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEE------KKRLL 1594
Query: 54 LQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQL 113
+++ REL ++ K +K+ ++D LE I+ A +E K+LR+L
Sbjct: 1595 IKQVRELEAELEDERKQRALAVASKKKMEIDLKD----LEAQIEAANKARDEVIKQLRKL 1650
Query: 114 RLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEM---E 170
+ +++ +LE R S +E Q+ ES + K LE E L L+EE+ E
Sbjct: 1651 QAQMKDYQRELEEAR--ASRDEIFAQSKESEKKLKSLEAEILQ--------LQEELASSE 1700
Query: 171 TKFSRWQKEQESIIQQL------QTSLHDRNKEVEARL 202
++E++ + ++ +++L D + +EAR+
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738
Score = 47.4 bits (111), Expect = 9e-06
Identities = 47/217 (21%), Positives = 95/217 (43%), Gaps = 18/217 (8%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
MEE L+ + + + + AE +++ +E+ ++L + +E ++ + E
Sbjct: 983 MEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEER 1042
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELR--------- 111
L+ + + + LE + L+ ++D+ L+ IDE L +KE+EL+
Sbjct: 1043 LKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDE 1102
Query: 112 -----QLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLK 166
VRE + L++ S +A+ E R E+E L T ++ L
Sbjct: 1103 TLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDT--LD 1160
Query: 167 EEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQ 203
+ R ++EQE + +L+ +L + K EA++Q
Sbjct: 1161 TTAAQQELRTKREQE--VAELKKALEEETKNHEAQIQ 1195
Score = 47.4 bits (111), Expect = 9e-06
Identities = 54/215 (25%), Positives = 95/215 (44%), Gaps = 29/215 (13%)
Query: 3 ELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ------- 55
EL+KAL++ + + + Q +R A E+ Q + + +L +Q L+
Sbjct: 1178 ELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELA 1237
Query: 56 -EFRELLQYRDNSD---KTLEANEMLL-------EKLRQRIRDKAVALERAIDEKFSALE 104
E + L Q + S+ K L+A L ++LR + +KA L+ +D + LE
Sbjct: 1238 CEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLE 1297
Query: 105 EKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQW 164
E EK+ + + L+ +++L E T Q + R + LE E+ +LQ
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELL--QEETRQKLNLSSRIRQLEEEK-----NSLQE 1350
Query: 165 LKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVE 199
+EE E +K E + LQ+ L D K+V+
Sbjct: 1351 QQEEEEEA----RKNLEKQVLALQSQLADTKKKVD 1381
Score = 46.6 bits (109), Expect = 2e-05
Identities = 50/230 (21%), Positives = 108/230 (46%), Gaps = 36/230 (15%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNE-------IRTQEQNIQHLNHSLSHKEQL 53
+EE+ + QQL EE ++QL+A E E + E + ++Q ++ + H L + +
Sbjct: 875 LEEMERKHQQLLEEKNILAEQLQA-ETELFAEAEEMRARLAAKKQELEEILHDLESRVEE 933
Query: 54 LQEFRELLQYRDNSDKTLEANEMLLEK-------LRQRIRDKAVALE---RAIDEKFSAL 103
+E ++LQ N K ++A+ LE+ RQ+++ + V E + ++E+ L
Sbjct: 934 EEERNQILQ---NEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLL 990
Query: 104 EE------KEKELRQLRLA-----VRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEV 152
E+ KEK+L + R+A + E + + L + + E + +E L+ +
Sbjct: 991 EDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTR 1050
Query: 153 EQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEARL 202
++L + L +++ + + Q + I +L+ L + +E++ L
Sbjct: 1051 QELEKAKRKLDGETTDLQDQIAELQAQ----IDELKLQLAKKEEELQGAL 1096
Score = 41.2 bits (95), Expect = 6e-04
Identities = 49/217 (22%), Positives = 91/217 (41%), Gaps = 22/217 (10%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
+E+ K L++LQ ++++ ++L A + +EI Q + + SL + ++LQ EL
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASR-DEIFAQSKESEKKLKSL--EAEILQLQEELA 1697
Query: 62 QYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 121
+S++ E ++L I + A +DEK E + QL + E
Sbjct: 1698 ----SSERARRHAEQERDELADEITNSASGKSALLDEK----RRLEARIAQLEEELEEEQ 1749
Query: 122 HDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEME----------- 170
++E L D + T+ + L A+ ++ Q L+ +E++
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVK 1809
Query: 171 TKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLR 207
+KF E+ I QL+ L KE A +L R
Sbjct: 1810 SKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRR 1846
Score = 38.1 bits (87), Expect = 0.005
Identities = 51/219 (23%), Positives = 95/219 (43%), Gaps = 39/219 (17%)
Query: 2 EELRKALQQLQEELQNK---SQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHK-------- 50
E RK L +EL K +LR AEK ++++ + N+ L K
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDA 1310
Query: 51 ---EQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKE 107
E LQ+ +ELLQ E+ RQ++ + R ++E+ ++L+E++
Sbjct: 1311 ASLESQLQDTQELLQ----------------EETRQKL--NLSSRIRQLEEEKNSLQEQQ 1352
Query: 108 KELRQLRLAVRERDHDLE-RLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLK 166
+E + R + ++ L+ +L D + + T+ESL AK ++ Q L
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL---- 1408
Query: 167 EEMETKFSRWQKEQESIIQQLQ--TSLHDRNKEVEARLQ 203
EE + + +K + + Q+L T D ++V + L+
Sbjct: 1409 EEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLE 1447
Score = 35.8 bits (81), Expect = 0.027
Identities = 47/189 (24%), Positives = 77/189 (40%), Gaps = 21/189 (11%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSL----SHKEQLLQEF 57
E R+ +Q ++EL ++ + ++ +E R E I L L S+ E L F
Sbjct: 1700 ERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRF 1759
Query: 58 R-----------ELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKF----SA 102
R EL R + K+ A + LE+ + ++ K LE A+ KF SA
Sbjct: 1760 RKTTLQVDTLNAELAAERSAAQKSDNARQQ-LERQNKELKAKLQELEGAVKSKFKATISA 1818
Query: 103 LEEKEKEL-RQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQN 161
LE K +L QL +ER + +R + +E R EQ+
Sbjct: 1819 LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANAR 1878
Query: 162 LQWLKEEME 170
++ LK ++E
Sbjct: 1879 MKQLKRQLE 1887
Score = 34.3 bits (77), Expect = 0.079
Identities = 40/169 (23%), Positives = 73/169 (43%), Gaps = 9/169 (5%)
Query: 50 KEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALE--RAIDEKFSALEEKE 107
+E+L + ELL+ ++ K E + K +Q + +K + E +A E F+ EE
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 108 KELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQL----STTCQNLQ 163
L + + E HDLE + +Q + ++A ++E+ Q LQ
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 970
Query: 164 WLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKE-VEARLQLTLRQLVQ 211
K E K + E+E ++ + Q S + K+ +E R+ QL +
Sbjct: 971 LEKVTAEAKIKK--MEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE 1017
Score = 28.5 bits (62), Expect = 4.4
Identities = 35/153 (22%), Positives = 71/153 (46%), Gaps = 17/153 (11%)
Query: 52 QLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELR 111
++ + + LLQ ++ +E LL ++++K +E LEE E++ +
Sbjct: 836 RVFTKVKPLLQVTRQEEELQAKDEELL-----KVKEKQTKVE-------GELEEMERKHQ 883
Query: 112 QLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 171
QL + E++ E+L+ + A + M + L AK E+E++ ++ +EE
Sbjct: 884 QL---LEEKNILAEQLQ-AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQ 939
Query: 172 KFSRWQKEQESIIQQLQTSLHDRNKEVEARLQL 204
+K+ ++ IQ L+ L D + +LQL
Sbjct: 940 ILQNEKKKMQAHIQDLEEQL-DEEEGARQKLQL 971
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 54.3 bits (129), Expect = 7e-08
Identities = 47/215 (21%), Positives = 103/215 (47%), Gaps = 18/215 (8%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
E+ ++ALQQLQ +L++ ++ R A+ + + + + LS + +Q R+ L
Sbjct: 863 EDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQAL 922
Query: 62 QYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 121
Q T ++ LL + Q + +A +R+ D++ L+ E+++ +L + E
Sbjct: 923 QASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEK 982
Query: 122 HDLERLRDVLSS-----NEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSR- 175
+ +E L D ++ ++ + M+ + LE +++S QN ++++T+ +
Sbjct: 983 NTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQN-----KDLKTRLASS 1037
Query: 176 --WQKEQESIIQQLQTSLHDRNKEVEARLQLTLRQ 208
+QK S+ Q L +N+ ++ RLQ R+
Sbjct: 1038 EGFQKPSASLSQ-----LESQNQLLQERLQAEERE 1067
Score = 48.9 bits (115), Expect = 3e-06
Identities = 59/224 (26%), Positives = 91/224 (40%), Gaps = 33/224 (14%)
Query: 3 ELRKALQQLQEELQNKSQQLRAWEAE-----------KYNEIRTQEQNIQHLNHSLSHKE 51
+L+K LQQL+++ + S+ EAE + TQE+N + L E
Sbjct: 685 QLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILG-LE 743
Query: 52 QLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELR 111
Q L+E R L+ + + +EA R+RDK LE + AL ++E
Sbjct: 744 QQLKETRGLV----DGGEAVEA----------RLRDKLQRLEAEKQQLEEALNASQEEEG 789
Query: 112 QLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 171
L A R + LE + L+ QT+ L +G + E L L+ K ++
Sbjct: 790 SLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDR 849
Query: 172 KFSRWQKEQESI-------IQQLQTSLHDRNKEVEARLQLTLRQ 208
R KE E I +QQLQ L D ++ + RQ
Sbjct: 850 TVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQ 893
Score = 47.8 bits (112), Expect = 7e-06
Identities = 51/231 (22%), Positives = 105/231 (45%), Gaps = 31/231 (13%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSH-KEQLLQEFRE 59
+EE+ + Q+++E+L+ + ++L A + E+ +++Q ++H+ EQL + ++
Sbjct: 476 LEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQD 535
Query: 60 LLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDE------KFSALEEKEK----- 108
Q + +LE RQ++ L+R ++E + ++ +K K
Sbjct: 536 ATQ-----------DHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRA 584
Query: 109 ---ELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWL 165
EL QLR+ E + +L +VL + R + ++L T + L+ L
Sbjct: 585 TKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKEL 644
Query: 166 KEEMETKFSRWQKEQESIIQQLQTSL--HDRNKEVE---ARLQLTLRQLVQ 211
+ E +++ + + +QL DR +E+E +LQ TL+QL Q
Sbjct: 645 QAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQ 695
Score = 44.3 bits (103), Expect = 8e-05
Identities = 53/224 (23%), Positives = 95/224 (42%), Gaps = 37/224 (16%)
Query: 2 EELRKALQQLQEELQN---KSQQLRAWEAEKYNEIRTQEQ--NIQHLNHSLS----HKEQ 52
EEL + ++ LQ EL+ + R E K +RTQE+ +Q S H+++
Sbjct: 601 EELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDR 660
Query: 53 LLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERA----------IDEKFSA 102
L++ +L+ + + LE + L+K Q++R +A + ++ +A
Sbjct: 661 ELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAA 720
Query: 103 LEEKEKELRQLRLAVRERDHDLE------------------RLRDVLSSNEATMQTMESL 144
+E +E ++ R R LE RLRD L EA Q +E
Sbjct: 721 VETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEA 780
Query: 145 LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQ 188
L A E L+ + L+ EE + +R +EQ+++ + L+
Sbjct: 781 LNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALE 824
Score = 43.1 bits (100), Expect = 2e-04
Identities = 50/210 (23%), Positives = 90/210 (42%), Gaps = 12/210 (5%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHK----EQLLQEF 57
E+LR L+ ELQNK + ++ E K ++ + + L L K EQL
Sbjct: 435 EDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRE 494
Query: 58 RELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAV 117
REL + + + + + +E +RQ+ + L R++ + E E +++ V
Sbjct: 495 RELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALV 554
Query: 118 RERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 177
R +LE + ++ Q + LRA E+ Q L+ KEEME +
Sbjct: 555 RGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQ-------LRMEKEEMEEELGEKI 607
Query: 178 KEQESIIQQLQTSLHDRNKEVEARLQLTLR 207
+ + ++Q + S D ++VE + LR
Sbjct: 608 EVLQRELEQARASAGD-TRQVEVLKKELLR 636
Score = 33.9 bits (76), Expect = 0.10
Identities = 41/183 (22%), Positives = 76/183 (41%), Gaps = 33/183 (18%)
Query: 5 RKALQQLQEELQNKSQQLRAWEAEKYN------EIRTQ---EQNIQHLNHSLSHKEQLLQ 55
R + QL+ EL + + E +K + +++T+ + Q + SLS E Q
Sbjct: 996 RDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQ 1055
Query: 56 EFRELLQYRDNSDKTLEANEMLLEKL-----------RQRIRD-------KAVALERAID 97
+E LQ + L++ LE+ RQ + D + AL+R +D
Sbjct: 1056 LLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVD 1115
Query: 98 EKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNE------ATMQTMESLLRAKGLE 151
E +E + ++ + V E+ E+L+ + S E A+ ES L+ +GL
Sbjct: 1116 EAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLS 1175
Query: 152 VEQ 154
++
Sbjct: 1176 SDE 1178
Score = 31.6 bits (70), Expect = 0.51
Identities = 27/137 (19%), Positives = 63/137 (45%), Gaps = 17/137 (12%)
Query: 80 KLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQ 139
K RQ++ V LER ++EK ++ L + + ++ + +L+ ++ +L E
Sbjct: 380 KKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRH 439
Query: 140 TMESLLR--------------AKGLEVEQLSTTCQNLQWL---KEEMETKFSRWQKEQES 182
+E+ + AK + ++ L T + L+ + K+ +E + ++E +
Sbjct: 440 GLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTA 499
Query: 183 IIQQLQTSLHDRNKEVE 199
+ L+ + R++EVE
Sbjct: 500 LKGALKEEVASRDQEVE 516
Score = 28.5 bits (62), Expect = 4.4
Identities = 32/166 (19%), Positives = 65/166 (39%), Gaps = 17/166 (10%)
Query: 53 LLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQ 112
+L++ + L+ S K + L K+ + L+R +DE+ ++ E
Sbjct: 340 VLEKMQPLVMVSSGSTKAVAGQGELTRKVEE--------LQRKLDEEVKKRQKLEPSQVG 391
Query: 113 LRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETK 172
L + E+ + RL+++L + Q L+ ++Q L+ E++ K
Sbjct: 392 LERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNK 451
Query: 173 FSRWQKEQESIIQQLQTSLHDR---------NKEVEARLQLTLRQL 209
Q + + L+ L R + VE +L+L R+L
Sbjct: 452 LKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLREREL 497
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 54.3 bits (129), Expect = 7e-08
Identities = 53/222 (23%), Positives = 101/222 (45%), Gaps = 25/222 (11%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQH----LNHSLSHKEQLL-- 54
+E L + ++ Q+E++N +QQ +A Y+++ + +Q L L ++ QL+
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEE-KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1445
Query: 55 -----QEFRELLQYRDN-SDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEK 108
++F +LL N S K + + + R++ KA++L RA++E A EE E+
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-ETKALSLARALEEALEAKEELER 1504
Query: 109 ELRQLRLAVRE----------RDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTT 158
+ L+ + + H+LE+ + L + M+T L + E
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564
Query: 159 CQ-NLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVE 199
+ N+Q LK + E ++ E +QLQ LH+ E+E
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606
Score = 50.4 bits (119), Expect = 1e-06
Identities = 53/215 (24%), Positives = 90/215 (41%), Gaps = 29/215 (13%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS-----------HK 50
EEL+ AL +L +E+ K+ L+ +IR E +I L L K
Sbjct: 1090 EELQAALARLDDEIAQKNNALK--------KIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 51 EQLLQEFREL-LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKE 109
L +E L + D D T E LR + + L++A+DE+ + E + +E
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Query: 110 LRQLRL-AVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEE 168
+RQ AV E LE+ + ++ + QT+E E+ L Q ++ K++
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 169 METKFSRWQ---KEQESIIQQLQTSLHDRNKEVEA 200
+E + Q + E +L +H EVE+
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1291
Score = 50.1 bits (118), Expect = 1e-06
Identities = 51/232 (21%), Positives = 97/232 (41%), Gaps = 25/232 (10%)
Query: 1 MEELRKALQQLQE---ELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 57
+EEL + L+Q + L Q L A+ E+R Q Q + H E +QE
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 58 RELLQYRDNSDKTLEANEMLLEKLRQRIRD----------KAVALERAIDEKFSALEEKE 107
+ + D E N+ + KL+ + KA+ L + + S L++ +
Sbjct: 1265 QS--KCSDGERARAELNDKV-HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 108 KELRQ-------LRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQ 160
+ L++ + +R+ + + L+D L Q +E + +++ Q
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 161 NLQWLKEEMETKFSRWQKEQESIIQQLQ--TSLHDRNKEVEARLQLTLRQLV 210
+ E +E R+QKE E++ QQ + + +D+ ++ + RLQ L LV
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433
Score = 49.7 bits (117), Expect = 2e-06
Identities = 52/214 (24%), Positives = 96/214 (44%), Gaps = 18/214 (8%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
MEE++ L++L++ELQ E E+++Q + K + LQ R+L
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ--RQL 1598
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
+Y + + L ++++ LE D EE K+LR+L+ +++
Sbjct: 1599 HEYETELEDERK-QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1657
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEM---ETKFSRWQ 177
+LE R S +E E+ +AK LE + L L+E++ E +
Sbjct: 1658 QRELEDAR--ASRDEIFATAKENEKKAKSLEAD--------LMQLQEDLAAAERARKQAD 1707
Query: 178 KEQESIIQQLQTSLHDRN--KEVEARLQLTLRQL 209
E+E + ++L +SL RN ++ + RL+ + QL
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Score = 45.8 bits (107), Expect = 3e-05
Identities = 37/199 (18%), Positives = 86/199 (43%), Gaps = 7/199 (3%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
+EE+ ++ EE +++ QQL+A E + Q + L L +E Q+ +
Sbjct: 920 LEEILHEMEARLEEEEDRGQQLQA-------ERKKMAQQMLDLEEQLEEEEAARQKLQLE 972
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
+ K LE ++++ ++ + LE I + + L E+E++ + L +
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ 180
+ + L L E + Q +E L R + +LQ E++ + ++ ++E
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1092
Query: 181 ESIIQQLQTSLHDRNKEVE 199
++ + +L + +N ++
Sbjct: 1093 QAALARLDDEIAQKNNALK 1111
Score = 42.7 bits (99), Expect = 2e-04
Identities = 43/209 (20%), Positives = 96/209 (45%), Gaps = 18/209 (8%)
Query: 11 LQEELQNKSQQLRAWEAEKYNEIRT----QEQNIQHLNHSLSHKEQLLQEFRELLQYRDN 66
+ ++ NK + R E+ +++ T +E+ ++L + E ++ E L+ +
Sbjct: 989 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1048
Query: 67 SDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELR----QLRLAVRERDH 122
S + LE + LE ++ L+ I E L +KE+EL+ +L + ++++
Sbjct: 1049 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1108
Query: 123 DLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS-------- 174
L+++R++ + ++S A+ +Q + L+ LK E+E
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Query: 175 RWQKEQESIIQQLQTSLHDRNKEVEARLQ 203
R ++EQE + L+ +L + + EA++Q
Sbjct: 1169 RAKREQE--VTVLKKALDEETRSHEAQVQ 1195
Score = 42.7 bits (99), Expect = 2e-04
Identities = 52/229 (22%), Positives = 104/229 (45%), Gaps = 22/229 (9%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
+E K + L+ +L + L A E + +E+ + L SLS + L E R L
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735
Query: 62 QYRDNSDKTLEANEMLLEKLRQRIR---------DKAVALERAIDEK-FSALEEKEKELR 111
++ LE + +E + R+R +A ER+ +K SA ++ E++ +
Sbjct: 1736 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1795
Query: 112 QLRLAVRERDHDLE-RLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTC-QNLQWLKE-- 167
+LR + E + ++ + + +++ EA + +E + + E + + + Q + LKE
Sbjct: 1796 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 168 ---EMETKFSRWQKEQ----ESIIQQLQTSLHDRNKEVEARLQLTLRQL 209
E E K + KEQ + ++QL+ L + +E + R+ R+L
Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ-RINANRRKL 1903
Score = 39.7 bits (91), Expect = 0.002
Identities = 44/216 (20%), Positives = 88/216 (40%), Gaps = 23/216 (10%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKE----QLLQE 56
+E +K L+ +ELQ+K AE +++ + ++ + L+ E +L ++
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309
Query: 57 FRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLA 116
L S + + E+L E+ RQ++ + K LEE+ L+
Sbjct: 1310 VASL------SSQLQDTQELLQEETRQKLN---------VSTKLRQLEEERNSLQDQLDE 1354
Query: 117 VRERDHDLER----LRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETK 172
E +LER L LS ++ +Q S + A ++ +NL EE
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414
Query: 173 FSRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLRQ 208
+ + +K + + Q+L + D + + + L +Q
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1450
Score = 33.9 bits (76), Expect = 0.10
Identities = 29/144 (20%), Positives = 64/144 (44%), Gaps = 4/144 (2%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNE-IRTQEQNIQHLNHSLSHKEQLLQEFREL 60
E R+ L++ +EL++K ++ K+ I E I L + + + Q +
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
L+ +D K + K+ ++ +++A + + LEE E+E +++ R+
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903
Query: 121 DHDLERLRDVLSSNEATMQTMESL 144
+L+ + SNEA + + +L
Sbjct: 1904 QRELD---EATESNEAMGREVNAL 1924
Score = 31.6 bits (70), Expect = 0.51
Identities = 20/115 (17%), Positives = 57/115 (49%), Gaps = 4/115 (3%)
Query: 4 LRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQY 63
L + QL+E+++ ++++ +A ++ +++ ++ + + + ++ ++++E +
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQA----ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874
Query: 64 RDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVR 118
+ K L+ E+ QRI L+R +DE + E +E+ L+ +R
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 54.3 bits (129), Expect = 7e-08
Identities = 53/222 (23%), Positives = 101/222 (45%), Gaps = 25/222 (11%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQH----LNHSLSHKEQLL-- 54
+E L + ++ Q+E++N +QQ +A Y+++ + +Q L L ++ QL+
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEE-KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1452
Query: 55 -----QEFRELLQYRDN-SDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEK 108
++F +LL N S K + + + R++ KA++L RA++E A EE E+
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-ETKALSLARALEEALEAKEELER 1511
Query: 109 ELRQLRLAVRE----------RDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTT 158
+ L+ + + H+LE+ + L + M+T L + E
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571
Query: 159 CQ-NLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVE 199
+ N+Q LK + E ++ E +QLQ LH+ E+E
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Score = 50.4 bits (119), Expect = 1e-06
Identities = 53/215 (24%), Positives = 90/215 (41%), Gaps = 29/215 (13%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS-----------HK 50
EEL+ AL +L +E+ K+ L+ +IR E +I L L K
Sbjct: 1097 EELQAALARLDDEIAQKNNALK--------KIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 51 EQLLQEFREL-LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKE 109
L +E L + D D T E LR + + L++A+DE+ + E + +E
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 110 LRQLRL-AVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEE 168
+RQ AV E LE+ + ++ + QT+E E+ L Q ++ K++
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 169 METKFSRWQ---KEQESIIQQLQTSLHDRNKEVEA 200
+E + Q + E +L +H EVE+
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1298
Score = 50.1 bits (118), Expect = 1e-06
Identities = 51/232 (21%), Positives = 97/232 (41%), Gaps = 25/232 (10%)
Query: 1 MEELRKALQQLQE---ELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 57
+EEL + L+Q + L Q L A+ E+R Q Q + H E +QE
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 58 RELLQYRDNSDKTLEANEMLLEKLRQRIRD----------KAVALERAIDEKFSALEEKE 107
+ + D E N+ + KL+ + KA+ L + + S L++ +
Sbjct: 1272 QS--KCSDGERARAELNDKV-HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 108 KELRQ-------LRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQ 160
+ L++ + +R+ + + L+D L Q +E + +++ Q
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 161 NLQWLKEEMETKFSRWQKEQESIIQQLQ--TSLHDRNKEVEARLQLTLRQLV 210
+ E +E R+QKE E++ QQ + + +D+ ++ + RLQ L LV
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440
Score = 49.7 bits (117), Expect = 2e-06
Identities = 52/214 (24%), Positives = 96/214 (44%), Gaps = 18/214 (8%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
MEE++ L++L++ELQ E E+++Q + K + LQ R+L
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ--RQL 1605
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
+Y + + L ++++ LE D EE K+LR+L+ +++
Sbjct: 1606 HEYETELEDERK-QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1664
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEM---ETKFSRWQ 177
+LE R S +E E+ +AK LE + L L+E++ E +
Sbjct: 1665 QRELEDAR--ASRDEIFATAKENEKKAKSLEAD--------LMQLQEDLAAAERARKQAD 1714
Query: 178 KEQESIIQQLQTSLHDRN--KEVEARLQLTLRQL 209
E+E + ++L +SL RN ++ + RL+ + QL
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Score = 45.8 bits (107), Expect = 3e-05
Identities = 37/199 (18%), Positives = 86/199 (43%), Gaps = 7/199 (3%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
+EE+ ++ EE +++ QQL+A E + Q + L L +E Q+ +
Sbjct: 927 LEEILHEMEARLEEEEDRGQQLQA-------ERKKMAQQMLDLEEQLEEEEAARQKLQLE 979
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
+ K LE ++++ ++ + LE I + + L E+E++ + L +
Sbjct: 980 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ 180
+ + L L E + Q +E L R + +LQ E++ + ++ ++E
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1099
Query: 181 ESIIQQLQTSLHDRNKEVE 199
++ + +L + +N ++
Sbjct: 1100 QAALARLDDEIAQKNNALK 1118
Score = 42.7 bits (99), Expect = 2e-04
Identities = 43/209 (20%), Positives = 96/209 (45%), Gaps = 18/209 (8%)
Query: 11 LQEELQNKSQQLRAWEAEKYNEIRT----QEQNIQHLNHSLSHKEQLLQEFRELLQYRDN 66
+ ++ NK + R E+ +++ T +E+ ++L + E ++ E L+ +
Sbjct: 996 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1055
Query: 67 SDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELR----QLRLAVRERDH 122
S + LE + LE ++ L+ I E L +KE+EL+ +L + ++++
Sbjct: 1056 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1115
Query: 123 DLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS-------- 174
L+++R++ + ++S A+ +Q + L+ LK E+E
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175
Query: 175 RWQKEQESIIQQLQTSLHDRNKEVEARLQ 203
R ++EQE + L+ +L + + EA++Q
Sbjct: 1176 RAKREQE--VTVLKKALDEETRSHEAQVQ 1202
Score = 42.7 bits (99), Expect = 2e-04
Identities = 52/229 (22%), Positives = 104/229 (45%), Gaps = 22/229 (9%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
+E K + L+ +L + L A E + +E+ + L SLS + L E R L
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Query: 62 QYRDNSDKTLEANEMLLEKLRQRIR---------DKAVALERAIDEK-FSALEEKEKELR 111
++ LE + +E + R+R +A ER+ +K SA ++ E++ +
Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1802
Query: 112 QLRLAVRERDHDLE-RLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTC-QNLQWLKE-- 167
+LR + E + ++ + + +++ EA + +E + + E + + + Q + LKE
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 168 ---EMETKFSRWQKEQ----ESIIQQLQTSLHDRNKEVEARLQLTLRQL 209
E E K + KEQ + ++QL+ L + +E + R+ R+L
Sbjct: 1863 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ-RINANRRKL 1910
Score = 39.7 bits (91), Expect = 0.002
Identities = 44/216 (20%), Positives = 88/216 (40%), Gaps = 23/216 (10%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKE----QLLQE 56
+E +K L+ +ELQ+K AE +++ + ++ + L+ E +L ++
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316
Query: 57 FRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLA 116
L S + + E+L E+ RQ++ + K LEE+ L+
Sbjct: 1317 VASL------SSQLQDTQELLQEETRQKLN---------VSTKLRQLEEERNSLQDQLDE 1361
Query: 117 VRERDHDLER----LRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETK 172
E +LER L LS ++ +Q S + A ++ +NL EE
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421
Query: 173 FSRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLRQ 208
+ + +K + + Q+L + D + + + L +Q
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1457
Score = 33.9 bits (76), Expect = 0.10
Identities = 29/144 (20%), Positives = 64/144 (44%), Gaps = 4/144 (2%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNE-IRTQEQNIQHLNHSLSHKEQLLQEFREL 60
E R+ L++ +EL++K ++ K+ I E I L + + + Q +
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
L+ +D K + K+ ++ +++A + + LEE E+E +++ R+
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910
Query: 121 DHDLERLRDVLSSNEATMQTMESL 144
+L+ + SNEA + + +L
Sbjct: 1911 QRELD---EATESNEAMGREVNAL 1931
Score = 31.6 bits (70), Expect = 0.51
Identities = 20/115 (17%), Positives = 57/115 (49%), Gaps = 4/115 (3%)
Query: 4 LRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQY 63
L + QL+E+++ ++++ +A ++ +++ ++ + + + ++ ++++E +
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQA----ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881
Query: 64 RDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVR 118
+ K L+ E+ QRI L+R +DE + E +E+ L+ +R
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 54.3 bits (129), Expect = 7e-08
Identities = 53/222 (23%), Positives = 101/222 (45%), Gaps = 25/222 (11%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQH----LNHSLSHKEQLL-- 54
+E L + ++ Q+E++N +QQ +A Y+++ + +Q L L ++ QL+
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEE-KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1452
Query: 55 -----QEFRELLQYRDN-SDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEK 108
++F +LL N S K + + + R++ KA++L RA++E A EE E+
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-ETKALSLARALEEALEAKEELER 1511
Query: 109 ELRQLRLAVRE----------RDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTT 158
+ L+ + + H+LE+ + L + M+T L + E
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571
Query: 159 CQ-NLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVE 199
+ N+Q LK + E ++ E +QLQ LH+ E+E
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Score = 50.4 bits (119), Expect = 1e-06
Identities = 53/215 (24%), Positives = 90/215 (41%), Gaps = 29/215 (13%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS-----------HK 50
EEL+ AL +L +E+ K+ L+ +IR E +I L L K
Sbjct: 1097 EELQAALARLDDEIAQKNNALK--------KIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 51 EQLLQEFREL-LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKE 109
L +E L + D D T E LR + + L++A+DE+ + E + +E
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 110 LRQLRL-AVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEE 168
+RQ AV E LE+ + ++ + QT+E E+ L Q ++ K++
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 169 METKFSRWQ---KEQESIIQQLQTSLHDRNKEVEA 200
+E + Q + E +L +H EVE+
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1298
Score = 50.1 bits (118), Expect = 1e-06
Identities = 51/232 (21%), Positives = 97/232 (41%), Gaps = 25/232 (10%)
Query: 1 MEELRKALQQLQE---ELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 57
+EEL + L+Q + L Q L A+ E+R Q Q + H E +QE
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 58 RELLQYRDNSDKTLEANEMLLEKLRQRIRD----------KAVALERAIDEKFSALEEKE 107
+ + D E N+ + KL+ + KA+ L + + S L++ +
Sbjct: 1272 QS--KCSDGERARAELNDKV-HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 108 KELRQ-------LRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQ 160
+ L++ + +R+ + + L+D L Q +E + +++ Q
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 161 NLQWLKEEMETKFSRWQKEQESIIQQLQ--TSLHDRNKEVEARLQLTLRQLV 210
+ E +E R+QKE E++ QQ + + +D+ ++ + RLQ L LV
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440
Score = 49.7 bits (117), Expect = 2e-06
Identities = 52/214 (24%), Positives = 96/214 (44%), Gaps = 18/214 (8%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
MEE++ L++L++ELQ E E+++Q + K + LQ R+L
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ--RQL 1605
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
+Y + + L ++++ LE D EE K+LR+L+ +++
Sbjct: 1606 HEYETELEDERK-QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1664
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEM---ETKFSRWQ 177
+LE R S +E E+ +AK LE + L L+E++ E +
Sbjct: 1665 QRELEDAR--ASRDEIFATAKENEKKAKSLEAD--------LMQLQEDLAAAERARKQAD 1714
Query: 178 KEQESIIQQLQTSLHDRN--KEVEARLQLTLRQL 209
E+E + ++L +SL RN ++ + RL+ + QL
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Score = 45.8 bits (107), Expect = 3e-05
Identities = 37/199 (18%), Positives = 86/199 (43%), Gaps = 7/199 (3%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
+EE+ ++ EE +++ QQL+A E + Q + L L +E Q+ +
Sbjct: 927 LEEILHEMEARLEEEEDRGQQLQA-------ERKKMAQQMLDLEEQLEEEEAARQKLQLE 979
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
+ K LE ++++ ++ + LE I + + L E+E++ + L +
Sbjct: 980 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ 180
+ + L L E + Q +E L R + +LQ E++ + ++ ++E
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1099
Query: 181 ESIIQQLQTSLHDRNKEVE 199
++ + +L + +N ++
Sbjct: 1100 QAALARLDDEIAQKNNALK 1118
Score = 42.7 bits (99), Expect = 2e-04
Identities = 43/209 (20%), Positives = 96/209 (45%), Gaps = 18/209 (8%)
Query: 11 LQEELQNKSQQLRAWEAEKYNEIRT----QEQNIQHLNHSLSHKEQLLQEFRELLQYRDN 66
+ ++ NK + R E+ +++ T +E+ ++L + E ++ E L+ +
Sbjct: 996 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1055
Query: 67 SDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELR----QLRLAVRERDH 122
S + LE + LE ++ L+ I E L +KE+EL+ +L + ++++
Sbjct: 1056 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1115
Query: 123 DLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS-------- 174
L+++R++ + ++S A+ +Q + L+ LK E+E
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175
Query: 175 RWQKEQESIIQQLQTSLHDRNKEVEARLQ 203
R ++EQE + L+ +L + + EA++Q
Sbjct: 1176 RAKREQE--VTVLKKALDEETRSHEAQVQ 1202
Score = 42.7 bits (99), Expect = 2e-04
Identities = 52/229 (22%), Positives = 104/229 (45%), Gaps = 22/229 (9%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
+E K + L+ +L + L A E + +E+ + L SLS + L E R L
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Query: 62 QYRDNSDKTLEANEMLLEKLRQRIR---------DKAVALERAIDEK-FSALEEKEKELR 111
++ LE + +E + R+R +A ER+ +K SA ++ E++ +
Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1802
Query: 112 QLRLAVRERDHDLE-RLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTC-QNLQWLKE-- 167
+LR + E + ++ + + +++ EA + +E + + E + + + Q + LKE
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 168 ---EMETKFSRWQKEQ----ESIIQQLQTSLHDRNKEVEARLQLTLRQL 209
E E K + KEQ + ++QL+ L + +E + R+ R+L
Sbjct: 1863 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ-RINANRRKL 1910
Score = 39.7 bits (91), Expect = 0.002
Identities = 44/216 (20%), Positives = 88/216 (40%), Gaps = 23/216 (10%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKE----QLLQE 56
+E +K L+ +ELQ+K AE +++ + ++ + L+ E +L ++
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316
Query: 57 FRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLA 116
L S + + E+L E+ RQ++ + K LEE+ L+
Sbjct: 1317 VASL------SSQLQDTQELLQEETRQKLN---------VSTKLRQLEEERNSLQDQLDE 1361
Query: 117 VRERDHDLER----LRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETK 172
E +LER L LS ++ +Q S + A ++ +NL EE
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421
Query: 173 FSRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLRQ 208
+ + +K + + Q+L + D + + + L +Q
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1457
Score = 33.9 bits (76), Expect = 0.10
Identities = 29/144 (20%), Positives = 64/144 (44%), Gaps = 4/144 (2%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNE-IRTQEQNIQHLNHSLSHKEQLLQEFREL 60
E R+ L++ +EL++K ++ K+ I E I L + + + Q +
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
L+ +D K + K+ ++ +++A + + LEE E+E +++ R+
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910
Query: 121 DHDLERLRDVLSSNEATMQTMESL 144
+L+ + SNEA + + +L
Sbjct: 1911 QRELD---EATESNEAMGREVNAL 1931
Score = 31.6 bits (70), Expect = 0.51
Identities = 20/115 (17%), Positives = 57/115 (49%), Gaps = 4/115 (3%)
Query: 4 LRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQY 63
L + QL+E+++ ++++ +A ++ +++ ++ + + + ++ ++++E +
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQA----ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881
Query: 64 RDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVR 118
+ K L+ E+ QRI L+R +DE + E +E+ L+ +R
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 54.3 bits (129), Expect = 7e-08
Identities = 53/222 (23%), Positives = 101/222 (45%), Gaps = 25/222 (11%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQH----LNHSLSHKEQLL-- 54
+E L + ++ Q+E++N +QQ +A Y+++ + +Q L L ++ QL+
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEE-KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1445
Query: 55 -----QEFRELLQYRDN-SDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEK 108
++F +LL N S K + + + R++ KA++L RA++E A EE E+
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-ETKALSLARALEEALEAKEELER 1504
Query: 109 ELRQLRLAVRE----------RDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTT 158
+ L+ + + H+LE+ + L + M+T L + E
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564
Query: 159 CQ-NLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVE 199
+ N+Q LK + E ++ E +QLQ LH+ E+E
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606
Score = 50.4 bits (119), Expect = 1e-06
Identities = 53/215 (24%), Positives = 90/215 (41%), Gaps = 29/215 (13%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS-----------HK 50
EEL+ AL +L +E+ K+ L+ +IR E +I L L K
Sbjct: 1090 EELQAALARLDDEIAQKNNALK--------KIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 51 EQLLQEFREL-LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKE 109
L +E L + D D T E LR + + L++A+DE+ + E + +E
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Query: 110 LRQLRL-AVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEE 168
+RQ AV E LE+ + ++ + QT+E E+ L Q ++ K++
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 169 METKFSRWQ---KEQESIIQQLQTSLHDRNKEVEA 200
+E + Q + E +L +H EVE+
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1291
Score = 50.1 bits (118), Expect = 1e-06
Identities = 51/232 (21%), Positives = 97/232 (41%), Gaps = 25/232 (10%)
Query: 1 MEELRKALQQLQE---ELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 57
+EEL + L+Q + L Q L A+ E+R Q Q + H E +QE
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 58 RELLQYRDNSDKTLEANEMLLEKLRQRIRD----------KAVALERAIDEKFSALEEKE 107
+ + D E N+ + KL+ + KA+ L + + S L++ +
Sbjct: 1265 QS--KCSDGERARAELNDKV-HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 108 KELRQ-------LRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQ 160
+ L++ + +R+ + + L+D L Q +E + +++ Q
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 161 NLQWLKEEMETKFSRWQKEQESIIQQLQ--TSLHDRNKEVEARLQLTLRQLV 210
+ E +E R+QKE E++ QQ + + +D+ ++ + RLQ L LV
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433
Score = 49.7 bits (117), Expect = 2e-06
Identities = 52/214 (24%), Positives = 96/214 (44%), Gaps = 18/214 (8%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
MEE++ L++L++ELQ E E+++Q + K + LQ R+L
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ--RQL 1598
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
+Y + + L ++++ LE D EE K+LR+L+ +++
Sbjct: 1599 HEYETELEDERK-QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1657
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEM---ETKFSRWQ 177
+LE R S +E E+ +AK LE + L L+E++ E +
Sbjct: 1658 QRELEDAR--ASRDEIFATAKENEKKAKSLEAD--------LMQLQEDLAAAERARKQAD 1707
Query: 178 KEQESIIQQLQTSLHDRN--KEVEARLQLTLRQL 209
E+E + ++L +SL RN ++ + RL+ + QL
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Score = 45.8 bits (107), Expect = 3e-05
Identities = 37/199 (18%), Positives = 86/199 (43%), Gaps = 7/199 (3%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
+EE+ ++ EE +++ QQL+A E + Q + L L +E Q+ +
Sbjct: 920 LEEILHEMEARLEEEEDRGQQLQA-------ERKKMAQQMLDLEEQLEEEEAARQKLQLE 972
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
+ K LE ++++ ++ + LE I + + L E+E++ + L +
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032
Query: 121 DHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ 180
+ + L L E + Q +E L R + +LQ E++ + ++ ++E
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1092
Query: 181 ESIIQQLQTSLHDRNKEVE 199
++ + +L + +N ++
Sbjct: 1093 QAALARLDDEIAQKNNALK 1111
Score = 42.7 bits (99), Expect = 2e-04
Identities = 43/209 (20%), Positives = 96/209 (45%), Gaps = 18/209 (8%)
Query: 11 LQEELQNKSQQLRAWEAEKYNEIRT----QEQNIQHLNHSLSHKEQLLQEFRELLQYRDN 66
+ ++ NK + R E+ +++ T +E+ ++L + E ++ E L+ +
Sbjct: 989 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1048
Query: 67 SDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELR----QLRLAVRERDH 122
S + LE + LE ++ L+ I E L +KE+EL+ +L + ++++
Sbjct: 1049 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1108
Query: 123 DLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS-------- 174
L+++R++ + ++S A+ +Q + L+ LK E+E
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Query: 175 RWQKEQESIIQQLQTSLHDRNKEVEARLQ 203
R ++EQE + L+ +L + + EA++Q
Sbjct: 1169 RAKREQE--VTVLKKALDEETRSHEAQVQ 1195
Score = 42.7 bits (99), Expect = 2e-04
Identities = 52/229 (22%), Positives = 104/229 (45%), Gaps = 22/229 (9%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
+E K + L+ +L + L A E + +E+ + L SLS + L E R L
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735
Query: 62 QYRDNSDKTLEANEMLLEKLRQRIR---------DKAVALERAIDEK-FSALEEKEKELR 111
++ LE + +E + R+R +A ER+ +K SA ++ E++ +
Sbjct: 1736 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1795
Query: 112 QLRLAVRERDHDLE-RLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTC-QNLQWLKE-- 167
+LR + E + ++ + + +++ EA + +E + + E + + + Q + LKE
Sbjct: 1796 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 168 ---EMETKFSRWQKEQ----ESIIQQLQTSLHDRNKEVEARLQLTLRQL 209
E E K + KEQ + ++QL+ L + +E + R+ R+L
Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ-RINANRRKL 1903
Score = 39.7 bits (91), Expect = 0.002
Identities = 44/216 (20%), Positives = 88/216 (40%), Gaps = 23/216 (10%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKE----QLLQE 56
+E +K L+ +ELQ+K AE +++ + ++ + L+ E +L ++
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309
Query: 57 FRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLA 116
L S + + E+L E+ RQ++ + K LEE+ L+
Sbjct: 1310 VASL------SSQLQDTQELLQEETRQKLN---------VSTKLRQLEEERNSLQDQLDE 1354
Query: 117 VRERDHDLER----LRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETK 172
E +LER L LS ++ +Q S + A ++ +NL EE
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414
Query: 173 FSRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLRQ 208
+ + +K + + Q+L + D + + + L +Q
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1450
Score = 33.9 bits (76), Expect = 0.10
Identities = 29/144 (20%), Positives = 64/144 (44%), Gaps = 4/144 (2%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNE-IRTQEQNIQHLNHSLSHKEQLLQEFREL 60
E R+ L++ +EL++K ++ K+ I E I L + + + Q +
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
L+ +D K + K+ ++ +++A + + LEE E+E +++ R+
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903
Query: 121 DHDLERLRDVLSSNEATMQTMESL 144
+L+ + SNEA + + +L
Sbjct: 1904 QRELD---EATESNEAMGREVNAL 1924
Score = 31.6 bits (70), Expect = 0.51
Identities = 20/115 (17%), Positives = 57/115 (49%), Gaps = 4/115 (3%)
Query: 4 LRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQY 63
L + QL+E+++ ++++ +A ++ +++ ++ + + + ++ ++++E +
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQA----ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874
Query: 64 RDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVR 118
+ K L+ E+ QRI L+R +DE + E +E+ L+ +R
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
>gi|167614504 laminin, beta 1 precursor [Homo sapiens]
Length = 1786
Score = 53.9 bits (128), Expect = 1e-07
Identities = 56/210 (26%), Positives = 94/210 (44%), Gaps = 17/210 (8%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQE-----QNIQHLNHSLSHKEQLLQE 56
EELR ++Q++ L S L + EA NE+ E Q +Q+L + + + L +
Sbjct: 1498 EELRNLIKQIRNFLTQDSADLDSIEAVA-NEVLKMEMPSTPQQLQNLTEDIRERVESLSQ 1556
Query: 57 FRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLA 116
+LQ+ S + EMLLE+ + R A ++ D ALEE EK A
Sbjct: 1557 VEVILQH---SAADIARAEMLLEEAK-RASKSATDVKVTADMVKEALEEAEKAQVAAEKA 1612
Query: 117 VRERDHDLERLRDVLSSNEATMQTMESLL-----RAKGLE--VEQLSTTCQNLQWLKEEM 169
+++ D D++ +++L+S E+ E L R LE VE+L E +
Sbjct: 1613 IKQADEDIQGTQNLLTSIESETAASEETLFNASQRISELERNVEELKRKAAQNSGEAEYI 1672
Query: 170 ETKFSRWQKEQESIIQQLQTSLHDRNKEVE 199
E ++ E + + L L ++ K+VE
Sbjct: 1673 EKVVYTVKQSAEDVKKTLDGELDEKYKKVE 1702
>gi|70166430 GRINL1A combined protein isoform 2 [Homo sapiens]
Length = 445
Score = 53.9 bits (128), Expect = 1e-07
Identities = 57/224 (25%), Positives = 111/224 (49%), Gaps = 39/224 (17%)
Query: 1 MEELRKALQQLQ-EELQNKSQQLRAWEAEKYN---------------EIRTQEQNIQHLN 44
M++LR+ +QL+ +++N+ +++ +++ N E + QE+ +H
Sbjct: 203 MDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHS- 261
Query: 45 HSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALE 104
+ KE LL+E L+ + ++K ++A E+ LE+ QRI + L+R I E
Sbjct: 262 ---AEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGE----LDRLI-------E 307
Query: 105 EKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLS--TTCQ-- 160
EKE QL+L + E H+ E ++ S++ Q +E + + L CQ
Sbjct: 308 RMEKERHQLQLQLLE--HETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQK 365
Query: 161 NLQWLKEEMETKFSRWQKEQESIIQQLQ--TSLHDRNKEVEARL 202
++ + EE+E+ + Q++Q I+Q L+ + L N E+++RL
Sbjct: 366 KVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRL 409
>gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens]
Length = 550
Score = 53.9 bits (128), Expect = 1e-07
Identities = 57/224 (25%), Positives = 111/224 (49%), Gaps = 39/224 (17%)
Query: 1 MEELRKALQQLQ-EELQNKSQQLRAWEAEKYN---------------EIRTQEQNIQHLN 44
M++LR+ +QL+ +++N+ +++ +++ N E + QE+ +H
Sbjct: 203 MDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHS- 261
Query: 45 HSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALE 104
+ KE LL+E L+ + ++K ++A E+ LE+ QRI + L+R I E
Sbjct: 262 ---AEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGE----LDRLI-------E 307
Query: 105 EKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLS--TTCQ-- 160
EKE QL+L + E H+ E ++ S++ Q +E + + L CQ
Sbjct: 308 RMEKERHQLQLQLLE--HETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQK 365
Query: 161 NLQWLKEEMETKFSRWQKEQESIIQQLQ--TSLHDRNKEVEARL 202
++ + EE+E+ + Q++Q I+Q L+ + L N E+++RL
Sbjct: 366 KVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRL 409
>gi|70166580 GRINL1A upstream protein isoform 7 [Homo sapiens]
Length = 466
Score = 53.9 bits (128), Expect = 1e-07
Identities = 57/224 (25%), Positives = 111/224 (49%), Gaps = 39/224 (17%)
Query: 1 MEELRKALQQLQ-EELQNKSQQLRAWEAEKYN---------------EIRTQEQNIQHLN 44
M++LR+ +QL+ +++N+ +++ +++ N E + QE+ +H
Sbjct: 203 MDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHS- 261
Query: 45 HSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALE 104
+ KE LL+E L+ + ++K ++A E+ LE+ QRI + L+R I E
Sbjct: 262 ---AEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGE----LDRLI-------E 307
Query: 105 EKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLS--TTCQ-- 160
EKE QL+L + E H+ E ++ S++ Q +E + + L CQ
Sbjct: 308 RMEKERHQLQLQLLE--HETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQK 365
Query: 161 NLQWLKEEMETKFSRWQKEQESIIQQLQ--TSLHDRNKEVEARL 202
++ + EE+E+ + Q++Q I+Q L+ + L N E+++RL
Sbjct: 366 KVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRL 409
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 53.9 bits (128), Expect = 1e-07
Identities = 44/203 (21%), Positives = 95/203 (46%), Gaps = 11/203 (5%)
Query: 3 ELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 62
EL+K + L+ L ++ R E ++++ + ++ LN +S + + +E Q
Sbjct: 961 ELKKEIDDLETMLVKSEKEKRTTE----HKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQ 1016
Query: 63 YRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDH 122
+TL+ M EKL + + LE+ +DE ALE++ K + + +
Sbjct: 1017 ------QTLDDLHMEEEKLSS-LSKANLKLEQQVDELEGALEQERKARMNCERELHKLEG 1069
Query: 123 DLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQES 182
+L+ R+ + + E++ + + LR K LE+ Q+++ +N + L +++ Q + +
Sbjct: 1070 NLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKD 1129
Query: 183 IIQQLQTSLHDRNKEVEARLQLT 205
+ ++L+ R K R LT
Sbjct: 1130 LKEKLEAERTTRAKMERERADLT 1152
Score = 46.2 bits (108), Expect = 2e-05
Identities = 47/227 (20%), Positives = 86/227 (37%), Gaps = 25/227 (11%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHK--------EQL 53
++L + +++ + S L+ A+ E+ Q +N+Q + L + L
Sbjct: 1184 QKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDL 1243
Query: 54 LQEFRELLQYRDNSDKTLEANE-------MLLEKLRQRIRDKAVALERAIDEK---FSAL 103
L ++ + + N++K E L+K+ Q D A + E L
Sbjct: 1244 LTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRL 1303
Query: 104 EEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQ 163
EEKE + QL +E LR L + + L+ + + L + Q
Sbjct: 1304 EEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQ 1363
Query: 164 WLKEEMETKFSR-------WQKEQESIIQQLQTSLHDRNKEVEARLQ 203
+K E+ S+ W+ + E+ + Q L D KE+ RLQ
Sbjct: 1364 EVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQ 1410
Score = 41.2 bits (95), Expect = 6e-04
Identities = 52/256 (20%), Positives = 101/256 (39%), Gaps = 67/256 (26%)
Query: 2 EELRKALQQLQEELQNKSQQLRAW-----EAEKYNEIRTQEQN-----IQHLNHSLSHKE 51
E LR+ + LQEE+ N + Q+R E EK ++ +E+ ++ +L E
Sbjct: 1508 ETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNE 1567
Query: 52 QLLQEFR-ELLQYRDNSDKTLEANEMLLEKLRQR-----------------IRDKAVALE 93
+ F+ ELL+ + ++ L + +E R++ R + L+
Sbjct: 1568 SKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLK 1627
Query: 94 RAIDEKFSALE-----------EKEKELRQLRLAVRERDHDLE---RLRDVLSSNEATMQ 139
+ ++E + +E E K L QL++ +++ L+ +L L A +
Sbjct: 1628 KKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAE 1687
Query: 140 TMESLL---------------RAKGLEVEQLSTTCQNLQWL----------KEEMETKFS 174
SLL R + L E+L + + K+++E +
Sbjct: 1688 RRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVA 1747
Query: 175 RWQKEQESIIQQLQTS 190
R QKE E ++Q+ Q +
Sbjct: 1748 RMQKEAEEVVQECQNA 1763
Score = 39.7 bits (91), Expect = 0.002
Identities = 52/230 (22%), Positives = 108/230 (46%), Gaps = 30/230 (13%)
Query: 3 ELRKALQQLQ---EELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHS----LSHKEQLLQ 55
+L+KAL++ + EEL+ K L + + +++ +++ + ++ + K QL
Sbjct: 870 QLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEA 929
Query: 56 EFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRL 115
+EL + + + E N L + R ++ D+ L++ ID+ + L + EKE R
Sbjct: 930 RVKELSERVEEEE---EINSELTARGR-KLEDECFELKKEIDDLETMLVKSEKEKRTTEH 985
Query: 116 AVRERDHDLERLRDVLSS--------NEATMQTMESLLRAKGLEVEQLSTTCQ---NLQW 164
V+ ++E L + +S EA QT++ L +E E+LS+ + L+
Sbjct: 986 KVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDL----HMEEEKLSSLSKANLKLEQ 1041
Query: 165 LKEEMETKFSRWQKEQ---ESIIQQLQTSLHDRNKEVEARLQLTLRQLVQ 211
+E+E + +K + E + +L+ +L N+E L+ + R L +
Sbjct: 1042 QVDELEGALEQERKARMNCERELHKLEGNL-KLNRESMENLESSQRHLAE 1090
Score = 37.4 bits (85), Expect = 0.009
Identities = 36/199 (18%), Positives = 84/199 (42%), Gaps = 11/199 (5%)
Query: 1 MEELRKALQQLQEEL----------QNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHK 50
+E+ RKA + EL + + L + + E+R +E + +N + ++
Sbjct: 1050 LEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENE 1109
Query: 51 EQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKE-KE 109
+ L+ + ++ ++ K L+ R ++ + L + + + LEE
Sbjct: 1110 KGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSS 1169
Query: 110 LRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEM 169
L QL + ++ + RD+ + T SL + + +L +NLQ +K+++
Sbjct: 1170 LAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKL 1229
Query: 170 ETKFSRWQKEQESIIQQLQ 188
E S Q E + ++ +++
Sbjct: 1230 EKDKSDLQLEVDDLLTRVE 1248
Score = 35.0 bits (79), Expect = 0.047
Identities = 40/205 (19%), Positives = 83/205 (40%), Gaps = 11/205 (5%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
E+L A ++L LQ ++ + A + R + Q L +LS ++ L
Sbjct: 1396 EDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLD 1455
Query: 62 QYRDNSDKTL-------EANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLR 114
Q + S K L E ++ LL+ ++ ++ AL + + + EE LR
Sbjct: 1456 QKQLQSGKALADWKQKHEESQALLDASQKEVQ----ALSTELLKLKNTYEESIVGQETLR 1511
Query: 115 LAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS 174
+ ++ L + + + ME + + E ++ T + + E E+K
Sbjct: 1512 RENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKIL 1571
Query: 175 RWQKEQESIIQQLQTSLHDRNKEVE 199
+Q E +L+ L ++++E+E
Sbjct: 1572 HFQLELLEAKAELERKLSEKDEEIE 1596
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 53.1 bits (126), Expect = 2e-07
Identities = 41/202 (20%), Positives = 91/202 (45%), Gaps = 11/202 (5%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEA---EKYNEIRTQEQNIQHLNHSLSHKEQLLQEFR 58
+ L K LQ + +LQ + ++ W ++ ++ QE+ IQ + +E+ ++E
Sbjct: 268 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327
Query: 59 ELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEE----KEKELRQLR 114
E + R+ +K EM+ EK + R + + E+ +EK EE KE+++R+
Sbjct: 328 EKI--REQEEKMRRQEEMMWEKEEKMRRQEEMMWEK--EEKMRRQEEMMWEKEEKMRRQE 383
Query: 115 LAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS 174
+ E++ + L + + E + E + + ++ + W +EE +
Sbjct: 384 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 443
Query: 175 RWQKEQESIIQQLQTSLHDRNK 196
+EQE + + + +H++ K
Sbjct: 444 EKIREQEKKMWRQEEKIHEQEK 465
Score = 47.8 bits (112), Expect = 7e-06
Identities = 37/184 (20%), Positives = 85/184 (46%), Gaps = 10/184 (5%)
Query: 12 QEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTL 71
++E + + Q+ + W E+ +IR QE+ Q + +E+ ++E E +Q ++ +
Sbjct: 574 RQEEKIREQEEKVWRQEE--KIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQ 631
Query: 72 EANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVL 131
E E++ Q +K E + E+ ++E+E+ + + +RE++ + + +
Sbjct: 632 EEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKI 691
Query: 132 SSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQK--EQESIIQQLQT 189
E MQ E + EQ C+ + ++E+ E + +K EQE ++Q +
Sbjct: 692 REQEEMMQEQEEKM------WEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 745
Query: 190 SLHD 193
+ +
Sbjct: 746 KMQE 749
Score = 47.4 bits (111), Expect = 9e-06
Identities = 46/218 (21%), Positives = 101/218 (46%), Gaps = 21/218 (9%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEA---EKYNEIRTQEQNIQHLNHSLSHKEQLLQE- 56
+ E + +++ +E + K +++R E EK ++R QE+ + + +E+++ E
Sbjct: 330 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 389
Query: 57 ---FRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAI---DEKFSALEEKEKEL 110
REL + +K E E E+ + R ++K E + +EK EEK +E
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 449
Query: 111 RQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEME 170
+ E+ H+ E++R+ E Q E + R + EQ + + KE+M
Sbjct: 450 EKKMWRQEEKIHEQEKIRE-----EEKRQEQEEMWRQEEKIHEQ-----EEIWRQKEKMH 499
Query: 171 TKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLRQ 208
+ + +K++E + +Q + + ++ +++ + + RQ
Sbjct: 500 EQEEKIRKQEEKVWRQ-EEKIREQEEKIREQEEKMWRQ 536
Score = 47.4 bits (111), Expect = 9e-06
Identities = 44/242 (18%), Positives = 106/242 (43%), Gaps = 41/242 (16%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
EE R+ ++++E+ + + Q+ + W E+ +IR QE+ I+ + +E+ + E ++
Sbjct: 410 EEKRQEEEKIREQEKRQEQEAKMWRQEE--KIREQEEKIREQEKKMWRQEEKIHEQEKIR 467
Query: 62 QYRDNSDKTLEANEMLL--EKLRQ-----RIRDKAVALERAIDEKFSALEEKEKELRQLR 114
+ +K E EM EK+ + R ++K E I ++ + +E+++R+
Sbjct: 468 E----EEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQE 523
Query: 115 LAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEE------ 168
+RE++ + R + + E + E + + + E+ ++ W +EE
Sbjct: 524 EKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQE 583
Query: 169 -----------------METKFSRWQ-----KEQESIIQQLQTSLHDRNKEVEARLQLTL 206
E + W+ +EQE IQ+ + + ++ +++ + ++T
Sbjct: 584 EKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQ 643
Query: 207 RQ 208
Q
Sbjct: 644 EQ 645
Score = 43.9 bits (102), Expect = 1e-04
Identities = 44/226 (19%), Positives = 96/226 (42%), Gaps = 38/226 (16%)
Query: 2 EELRKALQQLQEELQN-KSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 60
EE+ + +++ E+ + + Q+ + W E+ +IR QE+ I+ + +E+ ++E E+
Sbjct: 489 EEIWRQKEKMHEQEEKIRKQEEKVWRQEE--KIREQEEKIREQEEKMWRQEEKIREQEEM 546
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAI----------DEKFSALEEK---- 106
+ +K E ++ E+ RQ DK E I +EK EEK
Sbjct: 547 WR---EEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQ 603
Query: 107 --------------EKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEV 152
E+++++ +RE++ + ++ E M E K E
Sbjct: 604 EEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEE----KMCEQ 659
Query: 153 EQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEV 198
E+ + W +EE + + +EQE I++ + + ++ +++
Sbjct: 660 EEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 705
Score = 42.7 bits (99), Expect = 2e-04
Identities = 41/208 (19%), Positives = 102/208 (49%), Gaps = 26/208 (12%)
Query: 2 EELRKALQQLQEELQNKSQQLRAW--EAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRE 59
++L+ L +ELQ+ S +L+A E E +N + Q++ + +E+ +QE+ E
Sbjct: 261 QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE------KMWRQEEKIQEWEE 314
Query: 60 LLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALE-------EKEKELRQ 112
+Q ++ + E EK+R++ +K E + EK + EKE+++R+
Sbjct: 315 KIQEQEEKIREQE------EKIREQ-EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367
Query: 113 LRLAVRERDHDLERLRDVLSSNEATMQTMESLL--RAKGLEVEQLSTTCQNLQWLKEEME 170
+ E++ + R +++ E ++ +E + + K E E+ + ++ ++ E
Sbjct: 368 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 427
Query: 171 TKFSRWQKEQESIIQQLQTSLHDRNKEV 198
+ W++E++ I++ + + ++ K++
Sbjct: 428 QEAKMWRQEEK--IREQEEKIREQEKKM 453
Score = 31.2 bits (69), Expect = 0.67
Identities = 26/119 (21%), Positives = 54/119 (45%), Gaps = 11/119 (9%)
Query: 5 RKALQQLQEELQNKSQQLRAWEAEKYNE----IRTQEQNIQHLNHSLSHKEQLLQEFREL 60
++ + Q QEE + ++ + EK E + QE+ I+ + +E+ ++E E+
Sbjct: 638 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEM 697
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRE 119
+Q + +K E E + E+ +K E + + + E+E LRQ ++E
Sbjct: 698 MQ--EQEEKMWEQEEKMCEQ-----EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 53.1 bits (126), Expect = 2e-07
Identities = 44/212 (20%), Positives = 99/212 (46%), Gaps = 24/212 (11%)
Query: 9 QQLQEELQNKSQQLRAWEA---------EKYNEIRTQEQNIQHLNHSLSHKEQLLQE--- 56
+Q QEE+ + +++R E E+ +IR QE+ + + +E+ ++E
Sbjct: 519 RQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEE 578
Query: 57 --FRELLQYRDNSDKTLEANEMLLEK--LRQRIRDKAVALERAIDEKFSALEEKEKELRQ 112
+R+ + R+ +K E E + E+ + Q +K E + E+ ++E+E+++R+
Sbjct: 579 KVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRR 638
Query: 113 LRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETK 172
+RE++ + + + E MQ E + EQ C+ + ++E+ E
Sbjct: 639 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKM------WEQEEKMCEQEEKMQEQEEKM 692
Query: 173 FSRWQK--EQESIIQQLQTSLHDRNKEVEARL 202
+ +K EQE ++Q + + + + +EA +
Sbjct: 693 RRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724
Score = 52.4 bits (124), Expect = 3e-07
Identities = 46/218 (21%), Positives = 105/218 (48%), Gaps = 21/218 (9%)
Query: 1 MEELRKALQQLQEELQNKSQQLRAWEA---EKYNEIRTQEQNIQHLNHSLSHKEQLLQE- 56
++E + +++ +E+++ + +++R E EK ++R QE+ + + +E+++ E
Sbjct: 377 IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 436
Query: 57 ---FRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAI---DEKFSALEEKEKEL 110
REL + +K E E E+ + R ++K E + +EK EEK +E
Sbjct: 437 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 496
Query: 111 RQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEME 170
+ E+ H+ E++R+ E Q E + R + EQ + + KE++
Sbjct: 497 EEKMWRQEEKIHEQEKIRE-----EEKRQEQEEMWRQEEKIREQ-----EEIWRQKEKIH 546
Query: 171 TKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQLTLRQ 208
+ + +K++E + +Q + +HD+ +++ + + RQ
Sbjct: 547 EQEEKIRKQEEKMWRQ-EEKMHDQEEKIREQEEKVWRQ 583
Score = 48.9 bits (115), Expect = 3e-06
Identities = 42/201 (20%), Positives = 93/201 (46%), Gaps = 16/201 (7%)
Query: 2 EELRKALQQLQEELQNKSQQLRAW--EAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRE 59
++L+ L +ELQ+ S +L+A E E +N + Q++ + +E+ +QE+ E
Sbjct: 322 QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE------KMWRQEEKIQEWEE 375
Query: 60 LLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALE----EKEKELRQLRL 115
+Q + +K E E + E+ + R + + E+ +EK E EKE+++R+
Sbjct: 376 KIQ--EQEEKIREQEEKIREQEEKMRRQEEMMWEK--EEKMRRQEEMMWEKEEKMRRQEE 431
Query: 116 AVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSR 175
+ E++ + L + + E + E + + ++ + W +EE +
Sbjct: 432 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 491
Query: 176 WQKEQESIIQQLQTSLHDRNK 196
+EQE + + + +H++ K
Sbjct: 492 KIREQEEKMWRQEEKIHEQEK 512
Score = 43.9 bits (102), Expect = 1e-04
Identities = 53/237 (22%), Positives = 101/237 (42%), Gaps = 41/237 (17%)
Query: 2 EELRKALQQLQEELQ----NKSQ-QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQE 56
EEL++ +LQE+LQ KS+ QL E ++ E Q L H + LQ
Sbjct: 278 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 337
Query: 57 FRELLQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLA 116
LQ + +E NE L +L Q+ +K E I E ++E+E+++R+
Sbjct: 338 VSAKLQAQ------VEENE-LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK 390
Query: 117 VRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEE----METK 172
+RE++ + R +++ E M+ E ++ K E+ + + W KEE +E K
Sbjct: 391 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK----EEKMRRQEEMMWEKEEKIRELEEK 446
Query: 173 FSRWQ---------------------KEQESIIQQLQTSLHDRNKEVEARLQLTLRQ 208
+ +EQE+ + + + + ++ +++ + + RQ
Sbjct: 447 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQ 503
Score = 40.0 bits (92), Expect = 0.001
Identities = 44/232 (18%), Positives = 100/232 (43%), Gaps = 45/232 (19%)
Query: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
EE R+ ++++E+ + + Q+ + W E+ +IR QE+ I+ + +E+ + E ++
Sbjct: 457 EEKRQEEEKIREQEKRQEQEAKMWRQEE--KIREQEEKIREQEEKMWRQEEKIHEQEKIR 514
Query: 62 QYRDNSDKTLEANEMLL--EKLRQ-----RIRDKAVALERAI-----------------D 97
+ +K E EM EK+R+ R ++K E I +
Sbjct: 515 E----EEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQE 570
Query: 98 EKFSALEEK-----------EKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLR 146
EK EEK E+++R+ +RE++ + + + E M E ++
Sbjct: 571 EKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQ 630
Query: 147 AKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEV 198
+ ++ + + + E E K +EQE ++Q+ + + ++ +++
Sbjct: 631 EQEEKMRRQEEKIREQEKKIREQEEKI----REQEEMMQEQEEKMWEQEEKM 678
Score = 37.4 bits (85), Expect = 0.009
Identities = 29/125 (23%), Positives = 57/125 (45%), Gaps = 11/125 (8%)
Query: 5 RKALQQLQEELQNKSQQLRAWEAEKYNE----IRTQEQNIQHLNHSLSHKEQLLQEFREL 60
++ + Q QEE + ++ + EK E +R QE+ I+ + +E+ ++E E+
Sbjct: 604 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 663
Query: 61 LQYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 120
+Q + +K E E + E+ +K E + + + E+E LRQ ++E
Sbjct: 664 MQ--EQEEKMWEQEEKMCEQ-----EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEH 716
Query: 121 DHDLE 125
LE
Sbjct: 717 QEHLE 721
>gi|13540600 nudE nuclear distribution gene E homolog (A.
nidulans)-like 1 isoform B [Homo sapiens]
Length = 345
Score = 53.1 bits (126), Expect = 2e-07
Identities = 45/154 (29%), Positives = 81/154 (52%), Gaps = 14/154 (9%)
Query: 3 ELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 62
+L+ Q+L+ E++ ++L A+ Y ++ E + L+ + + KEQL + REL Q
Sbjct: 64 DLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDD---LSQTRAIKEQLHKYVRELEQ 120
Query: 63 YRDNSDKTLEANEMLLEKLRQRIR---DKAVALERAIDEKFS------ALEEKEKELRQL 113
D+ ++ A + LE QR+ ++ LE +DEK S L+++ ++LRQ
Sbjct: 121 ANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQ- 179
Query: 114 RLAVRERDHDLERLRDVLSSNEATMQTMESLLRA 147
LAVRER ++ R + SS + M+S ++A
Sbjct: 180 ELAVRERQQEVTR-KSAPSSPTLDCEKMDSAVQA 212
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.125 0.327
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 6,725,096
Number of Sequences: 37866
Number of extensions: 290815
Number of successful extensions: 6769
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 450
Number of HSP's successfully gapped in prelim test: 733
Number of HSP's that attempted gapping in prelim test: 2522
Number of HSP's gapped (non-prelim): 3398
length of query: 211
length of database: 18,247,518
effective HSP length: 98
effective length of query: 113
effective length of database: 14,536,650
effective search space: 1642641450
effective search space used: 1642641450
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.