Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 169215483
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169215483 PREDICTED: hypothetical protein isoform 2 [Homo
sapiens]
(356 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169215483 PREDICTED: hypothetical protein isoform 2 [Homo sap... 689 0.0
gi|169215927 PREDICTED: hypothetical protein [Homo sapiens] 681 0.0
gi|239752137 PREDICTED: hypothetical protein [Homo sapiens] 681 0.0
gi|169215514 PREDICTED: hypothetical protein [Homo sapiens] 677 0.0
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 62 1e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 62 1e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 62 1e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 62 1e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 62 1e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 62 1e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 62 1e-09
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 62 1e-09
gi|31982906 cingulin-like 1 [Homo sapiens] 60 3e-09
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 57 3e-08
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 57 3e-08
gi|21735548 centrosomal protein 2 [Homo sapiens] 56 6e-08
gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens] 55 7e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 55 1e-07
gi|238908495 similar to pleckstrin homology domain protein (5V32... 55 1e-07
gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens] 55 1e-07
gi|42794779 myosin 18A isoform b [Homo sapiens] 54 2e-07
gi|28416946 myosin 18A isoform a [Homo sapiens] 54 2e-07
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 54 2e-07
gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens] 54 3e-07
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 54 3e-07
gi|47519616 tropomyosin 2 (beta) isoform 2 [Homo sapiens] 54 3e-07
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 54 3e-07
gi|4505257 moesin [Homo sapiens] 53 5e-07
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 53 5e-07
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 53 5e-07
>gi|169215483 PREDICTED: hypothetical protein isoform 2 [Homo
sapiens]
Length = 356
Score = 689 bits (1779), Expect = 0.0
Identities = 356/356 (100%), Positives = 356/356 (100%)
Query: 1 MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK 60
MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK
Sbjct: 1 MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK 60
Query: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR 120
DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR
Sbjct: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR 120
Query: 121 ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVT 180
ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVT
Sbjct: 121 ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVT 180
Query: 181 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAE 240
LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAE
Sbjct: 181 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAE 240
Query: 241 ELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVLL 300
ELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVLL
Sbjct: 241 ELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVLL 300
Query: 301 TLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT 356
TLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT
Sbjct: 301 TLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT 356
>gi|169215927 PREDICTED: hypothetical protein [Homo sapiens]
Length = 357
Score = 681 bits (1757), Expect = 0.0
Identities = 355/357 (99%), Positives = 355/357 (99%), Gaps = 1/357 (0%)
Query: 1 MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK 60
MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK
Sbjct: 1 MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK 60
Query: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR 120
DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR
Sbjct: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR 120
Query: 121 ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY-GGEPQSQKSTEQQLAAQLV 179
ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY GGE QSQKSTEQQLAAQLV
Sbjct: 121 ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLV 180
Query: 180 TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA 239
TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA
Sbjct: 181 TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA 240
Query: 240 EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL 299
EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL
Sbjct: 241 EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL 300
Query: 300 LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT 356
LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT
Sbjct: 301 LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT 357
>gi|239752137 PREDICTED: hypothetical protein [Homo sapiens]
Length = 357
Score = 681 bits (1757), Expect = 0.0
Identities = 355/357 (99%), Positives = 355/357 (99%), Gaps = 1/357 (0%)
Query: 1 MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK 60
MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK
Sbjct: 1 MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK 60
Query: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR 120
DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR
Sbjct: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR 120
Query: 121 ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY-GGEPQSQKSTEQQLAAQLV 179
ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY GGE QSQKSTEQQLAAQLV
Sbjct: 121 ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLV 180
Query: 180 TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA 239
TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA
Sbjct: 181 TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA 240
Query: 240 EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL 299
EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL
Sbjct: 241 EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL 300
Query: 300 LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT 356
LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT
Sbjct: 301 LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT 357
>gi|169215514 PREDICTED: hypothetical protein [Homo sapiens]
Length = 357
Score = 677 bits (1748), Expect = 0.0
Identities = 354/357 (99%), Positives = 354/357 (99%), Gaps = 1/357 (0%)
Query: 1 MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK 60
MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK
Sbjct: 1 MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK 60
Query: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR 120
DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR
Sbjct: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR 120
Query: 121 ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY-GGEPQSQKSTEQQLAAQLV 179
ERAERVRRRLEEAERHKE LEQHSRQLQEQWEELSSQLFY GGE QSQKSTEQQLAAQLV
Sbjct: 121 ERAERVRRRLEEAERHKEYLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLV 180
Query: 180 TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA 239
TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA
Sbjct: 181 TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA 240
Query: 240 EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL 299
EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL
Sbjct: 241 EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL 300
Query: 300 LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT 356
LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT
Sbjct: 301 LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT 357
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 61.6 bits (148), Expect = 1e-09
Identities = 50/203 (24%), Positives = 101/203 (49%), Gaps = 6/203 (2%)
Query: 42 GSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL 101
G+ +AA QEL+ +L+ + G Q++Q LE+ + L+ E+ + Q+ Q+L E E + +
Sbjct: 1703 GTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL-EAELAKV 1760
Query: 102 RRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYG 161
R + + A E +R +E+ ++RLE +L + + +L+ EE Q
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820
Query: 162 GEPQSQKSTEQQ--LAAQLVTLQNELEL-AETKCALQEEKLQQDALQTAEAWAIFQEQTV 218
E +++ E + LA +L + L E + AL+E++ + + L+ FQ + +
Sbjct: 1821 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1880
Query: 219 VLQVRPH-SDAKEVQVKVMEAAE 240
Q H +D +E ++ +A++
Sbjct: 1881 EEQAAQHKADIEERLAQLRKASD 1903
Score = 60.1 bits (144), Expect = 3e-09
Identities = 70/248 (28%), Positives = 113/248 (45%), Gaps = 18/248 (7%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQE--------LEKLMRGLEAESESLNQRLQD-LSERE 97
A+ A +EL LQ ++ R RQ + E LE R EAE +S + ++ E
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQ---LQEQWEEL 154
RSL AQ L+ EA A+++AE R R EEAER E + + + L+ Q EE+
Sbjct: 1594 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEV 1651
Query: 155 SSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQE-EKLQQDALQTAEAWAIF 213
+ Q ++ E + A+ E + + + A QE EK +Q A TA+
Sbjct: 1652 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1711
Query: 214 QEQTVVLQVRPHSDAKEVQVKVMEAAE---ELDAWQSGRELCDGQLRGVQYSTESLMEEM 270
+++ + L+ ++ Q+ E A E A R+ + +L V+ E L+
Sbjct: 1712 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771
Query: 271 ARADRETR 278
ARA+ E+R
Sbjct: 1772 ARAEEESR 1779
Score = 55.8 bits (133), Expect = 6e-08
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 33/261 (12%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR-LQDLSERERSLL 101
S A A EL L+L GR R + L +AE E+ QR L ER R
Sbjct: 1933 SFEKAAAGKAELELEL------GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986
Query: 102 RRRSQAAQPLQGEA---REAARERAERVRRRLEEAERHKEDLEQHS-RQLQ--------- 148
R Q + + EA R+AA E ER++ ++EEA R +E EQ S RQLQ
Sbjct: 1987 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2046
Query: 149 EQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEE-------KLQQ 201
Q EE + + Q + T QQ + L L+ E E A EE + Q
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106
Query: 202 DALQTAEAWAIFQEQTVVLQVRPHSDA------KEVQVKVMEAAEELDAWQSGRELCDGQ 255
Q EA + Q Q R + A KE + + A+ A ++ D +
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2166
Query: 256 LRGVQYSTESLMEEMARADRE 276
+ + E + + A+ ++E
Sbjct: 2167 MEKHKKFAEQTLRQKAQVEQE 2187
Score = 52.8 bits (125), Expect = 5e-07
Identities = 55/236 (23%), Positives = 105/236 (44%), Gaps = 25/236 (10%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERER-------SLLRRRSQAAQPLQG--EAR 116
R R +E E R + E+E L +++QD S+R+R S ++ ++AA+ Q +A
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1538
Query: 117 EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAA 176
E R +AE RRL +AE + Q + + ++ E Q + E+ L
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598
Query: 177 QLVTLQNELELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVK 234
+ V + E AE + Q E+ +++A + E W + + + L+++ A++ +
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658
Query: 235 VMEAAE-----ELDAWQSG---------RELCDGQLRGVQYSTESLMEEMARADRE 276
EA + E +A + G REL + +L + E ++ A++E
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Score = 52.4 bits (124), Expect = 6e-07
Identities = 76/273 (27%), Positives = 121/273 (44%), Gaps = 54/273 (19%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL------RRRS 105
Q L + ++ RQ ++E E+L R ++ ES+ Q +L+ R ++ +R
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1535
Query: 106 QAAQPLQGEAREAAR-------ERAERVRRRLEEAERHKEDLEQHSR--------QLQEQ 150
QA + L+ +A EA R ERA +V+ LE A+R E Q R QL+
Sbjct: 1536 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595
Query: 151 WEE---LSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKC--ALQ-----EEKLQ 200
+E +QL E ++Q+ E + A + + ELE + K AL+ EE Q
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERARE--EAERELERWQLKANEALRLRLQAEEVAQ 1653
Query: 201 QDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG------ 254
Q +L AEA Q++ + R A+E V+ E AE+ + R+L +G
Sbjct: 1654 QKSLAQAEAEK--QKEEAEREARRRGKAEEQAVRQRELAEQ--ELEKQRQLAEGTAQQRL 1709
Query: 255 ----QLRGVQYSTES-------LMEEMARADRE 276
+L ++ TE L EE+AR RE
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/264 (23%), Positives = 107/264 (40%), Gaps = 29/264 (10%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHL----GSVSTAMAATQELLLQLQKDNRDGRQRKQELEK 74
+ L P+ +PA + G + + T + L Q K + +R +E E+
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 75 LMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAE 134
L AE ++ E++R L +QA + EA+E + E V RR E A
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA- 1408
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCAL 194
D +Q R +QE+ + QL E + Q Q AA+ L+ E E+ + L
Sbjct: 1409 ---VDAQQQKRSIQEELQ----QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 195 QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 254
+ + Q+ + E A+ + A+E + + +A EE + + R++ D
Sbjct: 1462 EATERQRGGAE-GELQAL------------RARAEEAEAQKRQAQEEAERLR--RQVQDE 1506
Query: 255 QLRGVQYSTE--SLMEEMARADRE 276
R Q E S ++ A A RE
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAARE 1530
Score = 47.0 bits (110), Expect = 3e-05
Identities = 63/256 (24%), Positives = 121/256 (47%), Gaps = 31/256 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDL-----SERERSLLRRRSQ 106
Q +L QL+ + R+ +E E+ E E+ +++++ S E++ R ++Q
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132
Query: 107 AA-QPLQGEAREAARERAERVRRRLE-------EAERHKEDLEQHSRQLQEQWEELSSQL 158
AA + L+ EA + A RA+ + L E E+HK+ EQ RQ + +EL++
Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2192
Query: 159 FYGGEPQSQKSTEQQLAAQLVTLQNE-LELAETKCALQEE----KLQQDALQTAEAWAIF 213
E QK+ L +L L+ E E A + ++EE ++Q + L +A
Sbjct: 2193 LQLEETDHQKNL---LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2249
Query: 214 QEQTVVLQVRPHS------DAKEVQVKVMEAAEELDAWQSG---RELCDGQLRGVQYSTE 264
+ + ++L+ + ++ +A++++ EAA A Q R+L + L + E
Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309
Query: 265 SLMEEMARADRE-TRL 279
+++E +A +E TRL
Sbjct: 2310 KMLKEKMQAVQEATRL 2325
Score = 46.6 bits (109), Expect = 3e-05
Identities = 65/266 (24%), Positives = 106/266 (39%), Gaps = 56/266 (21%)
Query: 52 QELLLQLQKDNRD-GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR-------- 102
QE +LQ+D +Q +E + R LEAE + ++L+ +E ER LR
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 103 -RRSQAAQPLQGEARE----------AARER-----------------AERVRRRLEEAE 134
R + AQ + +A E A +E+ AER+R + E E
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCAL 194
R KE L+Q ++ LQ + EE+ Q ++QL + LQ L+E L
Sbjct: 2457 REKEKLQQEAKLLQLKSEEM------------QTVQQEQLLQETQALQQSF-LSEKDSLL 2503
Query: 195 QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 254
Q E+ + + A+ +FQ++ Q ++ Q E + + + R
Sbjct: 2504 QRERFIEQ--EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561
Query: 255 QLRGVQYSTESLME-EMARADRETRL 279
GV+ E L + E R +E L
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELL 2587
Score = 44.7 bits (104), Expect = 1e-04
Identities = 44/192 (22%), Positives = 88/192 (45%), Gaps = 14/192 (7%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQ 112
E L +L+ + + +++ ++E+ + + + E L++ + R+L+ R Q
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF- 2265
Query: 113 GEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQ 172
+E AE++++ EEA R ++ +R Q E+L+ Q + +K
Sbjct: 2266 ------LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2319
Query: 173 Q----LAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQ---EQTVVLQVRPH 225
Q L A+ LQ + ELA+ + +E +Q A Q AE FQ E Q+
Sbjct: 2320 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2379
Query: 226 SDAKEVQVKVME 237
++A+ ++++V E
Sbjct: 2380 AEAERLKLRVAE 2391
Score = 42.7 bits (99), Expect = 5e-04
Identities = 70/286 (24%), Positives = 118/286 (41%), Gaps = 54/286 (18%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESES---LNQ 88
RL R G V +LL + Q R++ELE+L R L ES L
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSR--- 145
LQD RRR + Q + +A RE+ + + LEE ERH E +E+ R
Sbjct: 1222 WLQDA--------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1273
Query: 146 -----------QLQEQWEELSSQLFYGGEPQSQKSTEQQLA---------AQLVTLQNE- 184
QL +L +P+ Q +E + ++L TL ++
Sbjct: 1274 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333
Query: 185 -------LELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS------DAKEV 231
L E + L E++ ++ + AE A ++Q + + + +AKE+
Sbjct: 1334 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1393
Query: 232 QVKVMEAA---EE--LDAWQSGRELCDGQLRGVQYSTESLMEEMAR 272
Q ++ E EE +DA Q R + + +L+ ++ S+E+ ++ AR
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKAR 1438
Score = 41.6 bits (96), Expect = 0.001
Identities = 41/159 (25%), Positives = 71/159 (44%), Gaps = 11/159 (6%)
Query: 67 QRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERV 126
Q K +LE+L + A++ Q+L++ +R++ + + Q EAR E E V
Sbjct: 2511 QEKAKLEQLFQDEVAKA----QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 127 RRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGE------PQSQKSTEQQLAAQLVT 180
RR+ EE ++ ++ Q L E+ + L QL E S++ T Q+AA T
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA-TKT 2625
Query: 181 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVV 219
L N + + A E + D L+ + QE ++
Sbjct: 2626 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGIL 2664
Score = 35.4 bits (80), Expect = 0.079
Identities = 42/176 (23%), Positives = 83/176 (47%), Gaps = 23/176 (13%)
Query: 70 QELEKLMRGLEA---ESESLNQRLQDLSERERSL--LRRRSQAAQPLQGEARE---AARE 121
Q E+++R E E++++ L +L + SL LR +++A QP R+ A+E
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158
Query: 122 RAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTL 181
ER+++R E + E + QL E+W+ + +Q ++ +QL QL
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ------TDVRQRELEQLGRQLRYY 1212
Query: 182 QNELELAETKCALQEEKLQQDALQT---AEAWAI----FQEQTVVLQVRPHSDAKE 230
+ + LQ+ + +Q+ +Q A++ A+ QEQ ++ ++ H + E
Sbjct: 1213 RESAD--PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1266
Score = 32.3 bits (72), Expect = 0.67
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q+ + + Q+ + ++++Q++E+ + L A E +R + E +RR+ + Q L
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG----VRRKQEELQQL 2576
Query: 112 QGEAR---EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
+ + R E E +R+R +L+ E EQH L E +SQ+
Sbjct: 2577 EQQRRQQEELLAEENQRLREQLQLLE------EQHRAALAHSEEVTASQV 2620
Score = 28.9 bits (63), Expect = 7.4
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQE----LEKLMRGLEA----ESESLNQRLQDLSERERS 99
+ A+ E + Q + +G +RKQE LE+ R E E++ L ++LQ L E+ R+
Sbjct: 2548 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607
Query: 100 LLRRRSQAA--------------QPLQGEAREAARERAERVRRRLEEAERHKE 138
L + L G A EA E + RR A+R +E
Sbjct: 2608 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 61.6 bits (148), Expect = 1e-09
Identities = 50/203 (24%), Positives = 101/203 (49%), Gaps = 6/203 (2%)
Query: 42 GSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL 101
G+ +AA QEL+ +L+ + G Q++Q LE+ + L+ E+ + Q+ Q+L E E + +
Sbjct: 1707 GTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL-EAELAKV 1764
Query: 102 RRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYG 161
R + + A E +R +E+ ++RLE +L + + +L+ EE Q
Sbjct: 1765 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1824
Query: 162 GEPQSQKSTEQQ--LAAQLVTLQNELEL-AETKCALQEEKLQQDALQTAEAWAIFQEQTV 218
E +++ E + LA +L + L E + AL+E++ + + L+ FQ + +
Sbjct: 1825 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1884
Query: 219 VLQVRPH-SDAKEVQVKVMEAAE 240
Q H +D +E ++ +A++
Sbjct: 1885 EEQAAQHKADIEERLAQLRKASD 1907
Score = 60.1 bits (144), Expect = 3e-09
Identities = 70/248 (28%), Positives = 113/248 (45%), Gaps = 18/248 (7%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQE--------LEKLMRGLEAESESLNQRLQD-LSERE 97
A+ A +EL LQ ++ R RQ + E LE R EAE +S + ++ E
Sbjct: 1538 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1597
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQ---LQEQWEEL 154
RSL AQ L+ EA A+++AE R R EEAER E + + + L+ Q EE+
Sbjct: 1598 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEV 1655
Query: 155 SSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQE-EKLQQDALQTAEAWAIF 213
+ Q ++ E + A+ E + + + A QE EK +Q A TA+
Sbjct: 1656 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1715
Query: 214 QEQTVVLQVRPHSDAKEVQVKVMEAAE---ELDAWQSGRELCDGQLRGVQYSTESLMEEM 270
+++ + L+ ++ Q+ E A E A R+ + +L V+ E L+
Sbjct: 1716 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1775
Query: 271 ARADRETR 278
ARA+ E+R
Sbjct: 1776 ARAEEESR 1783
Score = 55.8 bits (133), Expect = 6e-08
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 33/261 (12%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR-LQDLSERERSLL 101
S A A EL L+L GR R + L +AE E+ QR L ER R
Sbjct: 1937 SFEKAAAGKAELELEL------GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1990
Query: 102 RRRSQAAQPLQGEA---REAARERAERVRRRLEEAERHKEDLEQHS-RQLQ--------- 148
R Q + + EA R+AA E ER++ ++EEA R +E EQ S RQLQ
Sbjct: 1991 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2050
Query: 149 EQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEE-------KLQQ 201
Q EE + + Q + T QQ + L L+ E E A EE + Q
Sbjct: 2051 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2110
Query: 202 DALQTAEAWAIFQEQTVVLQVRPHSDA------KEVQVKVMEAAEELDAWQSGRELCDGQ 255
Q EA + Q Q R + A KE + + A+ A ++ D +
Sbjct: 2111 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2170
Query: 256 LRGVQYSTESLMEEMARADRE 276
+ + E + + A+ ++E
Sbjct: 2171 MEKHKKFAEQTLRQKAQVEQE 2191
Score = 52.8 bits (125), Expect = 5e-07
Identities = 55/236 (23%), Positives = 105/236 (44%), Gaps = 25/236 (10%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERER-------SLLRRRSQAAQPLQG--EAR 116
R R +E E R + E+E L +++QD S+R+R S ++ ++AA+ Q +A
Sbjct: 1483 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1542
Query: 117 EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAA 176
E R +AE RRL +AE + Q + + ++ E Q + E+ L
Sbjct: 1543 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1602
Query: 177 QLVTLQNELELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVK 234
+ V + E AE + Q E+ +++A + E W + + + L+++ A++ +
Sbjct: 1603 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1662
Query: 235 VMEAAE-----ELDAWQSG---------RELCDGQLRGVQYSTESLMEEMARADRE 276
EA + E +A + G REL + +L + E ++ A++E
Sbjct: 1663 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1718
Score = 52.4 bits (124), Expect = 6e-07
Identities = 76/273 (27%), Positives = 121/273 (44%), Gaps = 54/273 (19%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL------RRRS 105
Q L + ++ RQ ++E E+L R ++ ES+ Q +L+ R ++ +R
Sbjct: 1480 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1539
Query: 106 QAAQPLQGEAREAAR-------ERAERVRRRLEEAERHKEDLEQHSR--------QLQEQ 150
QA + L+ +A EA R ERA +V+ LE A+R E Q R QL+
Sbjct: 1540 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1599
Query: 151 WEE---LSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKC--ALQ-----EEKLQ 200
+E +QL E ++Q+ E + A + + ELE + K AL+ EE Q
Sbjct: 1600 LQEEHVAVAQLREEAERRAQQQAEAERARE--EAERELERWQLKANEALRLRLQAEEVAQ 1657
Query: 201 QDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG------ 254
Q +L AEA Q++ + R A+E V+ E AE+ + R+L +G
Sbjct: 1658 QKSLAQAEAEK--QKEEAEREARRRGKAEEQAVRQRELAEQ--ELEKQRQLAEGTAQQRL 1713
Query: 255 ----QLRGVQYSTES-------LMEEMARADRE 276
+L ++ TE L EE+AR RE
Sbjct: 1714 AAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1746
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/264 (23%), Positives = 107/264 (40%), Gaps = 29/264 (10%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHL----GSVSTAMAATQELLLQLQKDNRDGRQRKQELEK 74
+ L P+ +PA + G + + T + L Q K + +R +E E+
Sbjct: 1294 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1353
Query: 75 LMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAE 134
L AE ++ E++R L +QA + EA+E + E V RR E A
Sbjct: 1354 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA- 1412
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCAL 194
D +Q R +QE+ + QL E + Q Q AA+ L+ E E+ + L
Sbjct: 1413 ---VDAQQQKRSIQEELQ----QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1465
Query: 195 QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 254
+ + Q+ + E A+ + A+E + + +A EE + + R++ D
Sbjct: 1466 EATERQRGGAE-GELQAL------------RARAEEAEAQKRQAQEEAERLR--RQVQDE 1510
Query: 255 QLRGVQYSTE--SLMEEMARADRE 276
R Q E S ++ A A RE
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAARE 1534
Score = 47.0 bits (110), Expect = 3e-05
Identities = 63/256 (24%), Positives = 121/256 (47%), Gaps = 31/256 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDL-----SERERSLLRRRSQ 106
Q +L QL+ + R+ +E E+ E E+ +++++ S E++ R ++Q
Sbjct: 2077 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2136
Query: 107 AA-QPLQGEAREAARERAERVRRRLE-------EAERHKEDLEQHSRQLQEQWEELSSQL 158
AA + L+ EA + A RA+ + L E E+HK+ EQ RQ + +EL++
Sbjct: 2137 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2196
Query: 159 FYGGEPQSQKSTEQQLAAQLVTLQNE-LELAETKCALQEE----KLQQDALQTAEAWAIF 213
E QK+ L +L L+ E E A + ++EE ++Q + L +A
Sbjct: 2197 LQLEETDHQKNL---LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2253
Query: 214 QEQTVVLQVRPHS------DAKEVQVKVMEAAEELDAWQSG---RELCDGQLRGVQYSTE 264
+ + ++L+ + ++ +A++++ EAA A Q R+L + L + E
Sbjct: 2254 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2313
Query: 265 SLMEEMARADRE-TRL 279
+++E +A +E TRL
Sbjct: 2314 KMLKEKMQAVQEATRL 2329
Score = 46.6 bits (109), Expect = 3e-05
Identities = 65/266 (24%), Positives = 106/266 (39%), Gaps = 56/266 (21%)
Query: 52 QELLLQLQKDNRD-GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR-------- 102
QE +LQ+D +Q +E + R LEAE + ++L+ +E ER LR
Sbjct: 2344 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQ 2400
Query: 103 -RRSQAAQPLQGEARE----------AARER-----------------AERVRRRLEEAE 134
R + AQ + +A E A +E+ AER+R + E E
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCAL 194
R KE L+Q ++ LQ + EE+ Q ++QL + LQ L+E L
Sbjct: 2461 REKEKLQQEAKLLQLKSEEM------------QTVQQEQLLQETQALQQSF-LSEKDSLL 2507
Query: 195 QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 254
Q E+ + + A+ +FQ++ Q ++ Q E + + + R
Sbjct: 2508 QRERFIEQ--EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2565
Query: 255 QLRGVQYSTESLME-EMARADRETRL 279
GV+ E L + E R +E L
Sbjct: 2566 AEEGVRRKQEELQQLEQQRRQQEELL 2591
Score = 44.7 bits (104), Expect = 1e-04
Identities = 44/192 (22%), Positives = 88/192 (45%), Gaps = 14/192 (7%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQ 112
E L +L+ + + +++ ++E+ + + + E L++ + R+L+ R Q
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF- 2269
Query: 113 GEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQ 172
+E AE++++ EEA R ++ +R Q E+L+ Q + +K
Sbjct: 2270 ------LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2323
Query: 173 Q----LAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQ---EQTVVLQVRPH 225
Q L A+ LQ + ELA+ + +E +Q A Q AE FQ E Q+
Sbjct: 2324 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2383
Query: 226 SDAKEVQVKVME 237
++A+ ++++V E
Sbjct: 2384 AEAERLKLRVAE 2395
Score = 42.7 bits (99), Expect = 5e-04
Identities = 70/286 (24%), Positives = 118/286 (41%), Gaps = 54/286 (18%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESES---LNQ 88
RL R G V +LL + Q R++ELE+L R L ES L
Sbjct: 1166 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1225
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSR--- 145
LQD RRR + Q + +A RE+ + + LEE ERH E +E+ R
Sbjct: 1226 WLQDA--------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1277
Query: 146 -----------QLQEQWEELSSQLFYGGEPQSQKSTEQQLA---------AQLVTLQNE- 184
QL +L +P+ Q +E + ++L TL ++
Sbjct: 1278 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1337
Query: 185 -------LELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS------DAKEV 231
L E + L E++ ++ + AE A ++Q + + + +AKE+
Sbjct: 1338 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1397
Query: 232 QVKVMEAA---EE--LDAWQSGRELCDGQLRGVQYSTESLMEEMAR 272
Q ++ E EE +DA Q R + + +L+ ++ S+E+ ++ AR
Sbjct: 1398 QQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKAR 1442
Score = 41.6 bits (96), Expect = 0.001
Identities = 41/159 (25%), Positives = 71/159 (44%), Gaps = 11/159 (6%)
Query: 67 QRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERV 126
Q K +LE+L + A++ Q+L++ +R++ + + Q EAR E E V
Sbjct: 2515 QEKAKLEQLFQDEVAKA----QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2570
Query: 127 RRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGE------PQSQKSTEQQLAAQLVT 180
RR+ EE ++ ++ Q L E+ + L QL E S++ T Q+AA T
Sbjct: 2571 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA-TKT 2629
Query: 181 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVV 219
L N + + A E + D L+ + QE ++
Sbjct: 2630 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGIL 2668
Score = 35.4 bits (80), Expect = 0.079
Identities = 42/176 (23%), Positives = 83/176 (47%), Gaps = 23/176 (13%)
Query: 70 QELEKLMRGLEA---ESESLNQRLQDLSERERSL--LRRRSQAAQPLQGEARE---AARE 121
Q E+++R E E++++ L +L + SL LR +++A QP R+ A+E
Sbjct: 1103 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1162
Query: 122 RAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTL 181
ER+++R E + E + QL E+W+ + +Q ++ +QL QL
Sbjct: 1163 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ------TDVRQRELEQLGRQLRYY 1216
Query: 182 QNELELAETKCALQEEKLQQDALQT---AEAWAI----FQEQTVVLQVRPHSDAKE 230
+ + LQ+ + +Q+ +Q A++ A+ QEQ ++ ++ H + E
Sbjct: 1217 RESAD--PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1270
Score = 32.3 bits (72), Expect = 0.67
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q+ + + Q+ + ++++Q++E+ + L A E +R + E +RR+ + Q L
Sbjct: 2525 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG----VRRKQEELQQL 2580
Query: 112 QGEAR---EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
+ + R E E +R+R +L+ E EQH L E +SQ+
Sbjct: 2581 EQQRRQQEELLAEENQRLREQLQLLE------EQHRAALAHSEEVTASQV 2624
Score = 28.9 bits (63), Expect = 7.4
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQE----LEKLMRGLEA----ESESLNQRLQDLSERERS 99
+ A+ E + Q + +G +RKQE LE+ R E E++ L ++LQ L E+ R+
Sbjct: 2552 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2611
Query: 100 LLRRRSQAA--------------QPLQGEAREAARERAERVRRRLEEAERHKE 138
L + L G A EA E + RR A+R +E
Sbjct: 2612 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2664
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 61.6 bits (148), Expect = 1e-09
Identities = 50/203 (24%), Positives = 101/203 (49%), Gaps = 6/203 (2%)
Query: 42 GSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL 101
G+ +AA QEL+ +L+ + G Q++Q LE+ + L+ E+ + Q+ Q+L E E + +
Sbjct: 1703 GTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL-EAELAKV 1760
Query: 102 RRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYG 161
R + + A E +R +E+ ++RLE +L + + +L+ EE Q
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820
Query: 162 GEPQSQKSTEQQ--LAAQLVTLQNELEL-AETKCALQEEKLQQDALQTAEAWAIFQEQTV 218
E +++ E + LA +L + L E + AL+E++ + + L+ FQ + +
Sbjct: 1821 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1880
Query: 219 VLQVRPH-SDAKEVQVKVMEAAE 240
Q H +D +E ++ +A++
Sbjct: 1881 EEQAAQHKADIEERLAQLRKASD 1903
Score = 60.1 bits (144), Expect = 3e-09
Identities = 70/248 (28%), Positives = 113/248 (45%), Gaps = 18/248 (7%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQE--------LEKLMRGLEAESESLNQRLQD-LSERE 97
A+ A +EL LQ ++ R RQ + E LE R EAE +S + ++ E
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQ---LQEQWEEL 154
RSL AQ L+ EA A+++AE R R EEAER E + + + L+ Q EE+
Sbjct: 1594 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEV 1651
Query: 155 SSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQE-EKLQQDALQTAEAWAIF 213
+ Q ++ E + A+ E + + + A QE EK +Q A TA+
Sbjct: 1652 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1711
Query: 214 QEQTVVLQVRPHSDAKEVQVKVMEAAE---ELDAWQSGRELCDGQLRGVQYSTESLMEEM 270
+++ + L+ ++ Q+ E A E A R+ + +L V+ E L+
Sbjct: 1712 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771
Query: 271 ARADRETR 278
ARA+ E+R
Sbjct: 1772 ARAEEESR 1779
Score = 55.8 bits (133), Expect = 6e-08
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 33/261 (12%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR-LQDLSERERSLL 101
S A A EL L+L GR R + L +AE E+ QR L ER R
Sbjct: 1933 SFEKAAAGKAELELEL------GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986
Query: 102 RRRSQAAQPLQGEA---REAARERAERVRRRLEEAERHKEDLEQHS-RQLQ--------- 148
R Q + + EA R+AA E ER++ ++EEA R +E EQ S RQLQ
Sbjct: 1987 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2046
Query: 149 EQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEE-------KLQQ 201
Q EE + + Q + T QQ + L L+ E E A EE + Q
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106
Query: 202 DALQTAEAWAIFQEQTVVLQVRPHSDA------KEVQVKVMEAAEELDAWQSGRELCDGQ 255
Q EA + Q Q R + A KE + + A+ A ++ D +
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2166
Query: 256 LRGVQYSTESLMEEMARADRE 276
+ + E + + A+ ++E
Sbjct: 2167 MEKHKKFAEQTLRQKAQVEQE 2187
Score = 52.8 bits (125), Expect = 5e-07
Identities = 55/236 (23%), Positives = 105/236 (44%), Gaps = 25/236 (10%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERER-------SLLRRRSQAAQPLQG--EAR 116
R R +E E R + E+E L +++QD S+R+R S ++ ++AA+ Q +A
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1538
Query: 117 EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAA 176
E R +AE RRL +AE + Q + + ++ E Q + E+ L
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598
Query: 177 QLVTLQNELELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVK 234
+ V + E AE + Q E+ +++A + E W + + + L+++ A++ +
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658
Query: 235 VMEAAE-----ELDAWQSG---------RELCDGQLRGVQYSTESLMEEMARADRE 276
EA + E +A + G REL + +L + E ++ A++E
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Score = 52.4 bits (124), Expect = 6e-07
Identities = 76/273 (27%), Positives = 121/273 (44%), Gaps = 54/273 (19%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL------RRRS 105
Q L + ++ RQ ++E E+L R ++ ES+ Q +L+ R ++ +R
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1535
Query: 106 QAAQPLQGEAREAAR-------ERAERVRRRLEEAERHKEDLEQHSR--------QLQEQ 150
QA + L+ +A EA R ERA +V+ LE A+R E Q R QL+
Sbjct: 1536 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595
Query: 151 WEE---LSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKC--ALQ-----EEKLQ 200
+E +QL E ++Q+ E + A + + ELE + K AL+ EE Q
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERARE--EAERELERWQLKANEALRLRLQAEEVAQ 1653
Query: 201 QDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG------ 254
Q +L AEA Q++ + R A+E V+ E AE+ + R+L +G
Sbjct: 1654 QKSLAQAEAEK--QKEEAEREARRRGKAEEQAVRQRELAEQ--ELEKQRQLAEGTAQQRL 1709
Query: 255 ----QLRGVQYSTES-------LMEEMARADRE 276
+L ++ TE L EE+AR RE
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/264 (23%), Positives = 107/264 (40%), Gaps = 29/264 (10%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHL----GSVSTAMAATQELLLQLQKDNRDGRQRKQELEK 74
+ L P+ +PA + G + + T + L Q K + +R +E E+
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 75 LMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAE 134
L AE ++ E++R L +QA + EA+E + E V RR E A
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA- 1408
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCAL 194
D +Q R +QE+ + QL E + Q Q AA+ L+ E E+ + L
Sbjct: 1409 ---VDAQQQKRSIQEELQ----QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 195 QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 254
+ + Q+ + E A+ + A+E + + +A EE + + R++ D
Sbjct: 1462 EATERQRGGAE-GELQAL------------RARAEEAEAQKRQAQEEAERLR--RQVQDE 1506
Query: 255 QLRGVQYSTE--SLMEEMARADRE 276
R Q E S ++ A A RE
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAARE 1530
Score = 47.0 bits (110), Expect = 3e-05
Identities = 63/256 (24%), Positives = 121/256 (47%), Gaps = 31/256 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDL-----SERERSLLRRRSQ 106
Q +L QL+ + R+ +E E+ E E+ +++++ S E++ R ++Q
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132
Query: 107 AA-QPLQGEAREAARERAERVRRRLE-------EAERHKEDLEQHSRQLQEQWEELSSQL 158
AA + L+ EA + A RA+ + L E E+HK+ EQ RQ + +EL++
Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2192
Query: 159 FYGGEPQSQKSTEQQLAAQLVTLQNE-LELAETKCALQEE----KLQQDALQTAEAWAIF 213
E QK+ L +L L+ E E A + ++EE ++Q + L +A
Sbjct: 2193 LQLEETDHQKNL---LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2249
Query: 214 QEQTVVLQVRPHS------DAKEVQVKVMEAAEELDAWQSG---RELCDGQLRGVQYSTE 264
+ + ++L+ + ++ +A++++ EAA A Q R+L + L + E
Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309
Query: 265 SLMEEMARADRE-TRL 279
+++E +A +E TRL
Sbjct: 2310 KMLKEKMQAVQEATRL 2325
Score = 46.6 bits (109), Expect = 3e-05
Identities = 65/266 (24%), Positives = 106/266 (39%), Gaps = 56/266 (21%)
Query: 52 QELLLQLQKDNRD-GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR-------- 102
QE +LQ+D +Q +E + R LEAE + ++L+ +E ER LR
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 103 -RRSQAAQPLQGEARE----------AARER-----------------AERVRRRLEEAE 134
R + AQ + +A E A +E+ AER+R + E E
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCAL 194
R KE L+Q ++ LQ + EE+ Q ++QL + LQ L+E L
Sbjct: 2457 REKEKLQQEAKLLQLKSEEM------------QTVQQEQLLQETQALQQSF-LSEKDSLL 2503
Query: 195 QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 254
Q E+ + + A+ +FQ++ Q ++ Q E + + + R
Sbjct: 2504 QRERFIEQ--EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561
Query: 255 QLRGVQYSTESLME-EMARADRETRL 279
GV+ E L + E R +E L
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELL 2587
Score = 44.7 bits (104), Expect = 1e-04
Identities = 44/192 (22%), Positives = 88/192 (45%), Gaps = 14/192 (7%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQ 112
E L +L+ + + +++ ++E+ + + + E L++ + R+L+ R Q
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF- 2265
Query: 113 GEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQ 172
+E AE++++ EEA R ++ +R Q E+L+ Q + +K
Sbjct: 2266 ------LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2319
Query: 173 Q----LAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQ---EQTVVLQVRPH 225
Q L A+ LQ + ELA+ + +E +Q A Q AE FQ E Q+
Sbjct: 2320 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2379
Query: 226 SDAKEVQVKVME 237
++A+ ++++V E
Sbjct: 2380 AEAERLKLRVAE 2391
Score = 42.7 bits (99), Expect = 5e-04
Identities = 70/286 (24%), Positives = 118/286 (41%), Gaps = 54/286 (18%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESES---LNQ 88
RL R G V +LL + Q R++ELE+L R L ES L
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSR--- 145
LQD RRR + Q + +A RE+ + + LEE ERH E +E+ R
Sbjct: 1222 WLQDA--------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1273
Query: 146 -----------QLQEQWEELSSQLFYGGEPQSQKSTEQQLA---------AQLVTLQNE- 184
QL +L +P+ Q +E + ++L TL ++
Sbjct: 1274 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333
Query: 185 -------LELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS------DAKEV 231
L E + L E++ ++ + AE A ++Q + + + +AKE+
Sbjct: 1334 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1393
Query: 232 QVKVMEAA---EE--LDAWQSGRELCDGQLRGVQYSTESLMEEMAR 272
Q ++ E EE +DA Q R + + +L+ ++ S+E+ ++ AR
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKAR 1438
Score = 41.6 bits (96), Expect = 0.001
Identities = 41/159 (25%), Positives = 71/159 (44%), Gaps = 11/159 (6%)
Query: 67 QRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERV 126
Q K +LE+L + A++ Q+L++ +R++ + + Q EAR E E V
Sbjct: 2511 QEKAKLEQLFQDEVAKA----QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 127 RRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGE------PQSQKSTEQQLAAQLVT 180
RR+ EE ++ ++ Q L E+ + L QL E S++ T Q+AA T
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA-TKT 2625
Query: 181 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVV 219
L N + + A E + D L+ + QE ++
Sbjct: 2626 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGIL 2664
Score = 35.4 bits (80), Expect = 0.079
Identities = 42/176 (23%), Positives = 83/176 (47%), Gaps = 23/176 (13%)
Query: 70 QELEKLMRGLEA---ESESLNQRLQDLSERERSL--LRRRSQAAQPLQGEARE---AARE 121
Q E+++R E E++++ L +L + SL LR +++A QP R+ A+E
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158
Query: 122 RAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTL 181
ER+++R E + E + QL E+W+ + +Q ++ +QL QL
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ------TDVRQRELEQLGRQLRYY 1212
Query: 182 QNELELAETKCALQEEKLQQDALQT---AEAWAI----FQEQTVVLQVRPHSDAKE 230
+ + LQ+ + +Q+ +Q A++ A+ QEQ ++ ++ H + E
Sbjct: 1213 RESAD--PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1266
Score = 32.3 bits (72), Expect = 0.67
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q+ + + Q+ + ++++Q++E+ + L A E +R + E +RR+ + Q L
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG----VRRKQEELQQL 2576
Query: 112 QGEAR---EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
+ + R E E +R+R +L+ E EQH L E +SQ+
Sbjct: 2577 EQQRRQQEELLAEENQRLREQLQLLE------EQHRAALAHSEEVTASQV 2620
Score = 28.9 bits (63), Expect = 7.4
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQE----LEKLMRGLEA----ESESLNQRLQDLSERERS 99
+ A+ E + Q + +G +RKQE LE+ R E E++ L ++LQ L E+ R+
Sbjct: 2548 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607
Query: 100 LLRRRSQAA--------------QPLQGEAREAARERAERVRRRLEEAERHKE 138
L + L G A EA E + RR A+R +E
Sbjct: 2608 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 61.6 bits (148), Expect = 1e-09
Identities = 50/203 (24%), Positives = 101/203 (49%), Gaps = 6/203 (2%)
Query: 42 GSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL 101
G+ +AA QEL+ +L+ + G Q++Q LE+ + L+ E+ + Q+ Q+L E E + +
Sbjct: 1671 GTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL-EAELAKV 1728
Query: 102 RRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYG 161
R + + A E +R +E+ ++RLE +L + + +L+ EE Q
Sbjct: 1729 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1788
Query: 162 GEPQSQKSTEQQ--LAAQLVTLQNELEL-AETKCALQEEKLQQDALQTAEAWAIFQEQTV 218
E +++ E + LA +L + L E + AL+E++ + + L+ FQ + +
Sbjct: 1789 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1848
Query: 219 VLQVRPH-SDAKEVQVKVMEAAE 240
Q H +D +E ++ +A++
Sbjct: 1849 EEQAAQHKADIEERLAQLRKASD 1871
Score = 60.1 bits (144), Expect = 3e-09
Identities = 70/248 (28%), Positives = 113/248 (45%), Gaps = 18/248 (7%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQE--------LEKLMRGLEAESESLNQRLQD-LSERE 97
A+ A +EL LQ ++ R RQ + E LE R EAE +S + ++ E
Sbjct: 1502 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1561
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQ---LQEQWEEL 154
RSL AQ L+ EA A+++AE R R EEAER E + + + L+ Q EE+
Sbjct: 1562 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEV 1619
Query: 155 SSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQE-EKLQQDALQTAEAWAIF 213
+ Q ++ E + A+ E + + + A QE EK +Q A TA+
Sbjct: 1620 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1679
Query: 214 QEQTVVLQVRPHSDAKEVQVKVMEAAE---ELDAWQSGRELCDGQLRGVQYSTESLMEEM 270
+++ + L+ ++ Q+ E A E A R+ + +L V+ E L+
Sbjct: 1680 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1739
Query: 271 ARADRETR 278
ARA+ E+R
Sbjct: 1740 ARAEEESR 1747
Score = 55.8 bits (133), Expect = 6e-08
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 33/261 (12%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR-LQDLSERERSLL 101
S A A EL L+L GR R + L +AE E+ QR L ER R
Sbjct: 1901 SFEKAAAGKAELELEL------GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1954
Query: 102 RRRSQAAQPLQGEA---REAARERAERVRRRLEEAERHKEDLEQHS-RQLQ--------- 148
R Q + + EA R+AA E ER++ ++EEA R +E EQ S RQLQ
Sbjct: 1955 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2014
Query: 149 EQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEE-------KLQQ 201
Q EE + + Q + T QQ + L L+ E E A EE + Q
Sbjct: 2015 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2074
Query: 202 DALQTAEAWAIFQEQTVVLQVRPHSDA------KEVQVKVMEAAEELDAWQSGRELCDGQ 255
Q EA + Q Q R + A KE + + A+ A ++ D +
Sbjct: 2075 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2134
Query: 256 LRGVQYSTESLMEEMARADRE 276
+ + E + + A+ ++E
Sbjct: 2135 MEKHKKFAEQTLRQKAQVEQE 2155
Score = 52.8 bits (125), Expect = 5e-07
Identities = 55/236 (23%), Positives = 105/236 (44%), Gaps = 25/236 (10%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERER-------SLLRRRSQAAQPLQG--EAR 116
R R +E E R + E+E L +++QD S+R+R S ++ ++AA+ Q +A
Sbjct: 1447 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1506
Query: 117 EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAA 176
E R +AE RRL +AE + Q + + ++ E Q + E+ L
Sbjct: 1507 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1566
Query: 177 QLVTLQNELELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVK 234
+ V + E AE + Q E+ +++A + E W + + + L+++ A++ +
Sbjct: 1567 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1626
Query: 235 VMEAAE-----ELDAWQSG---------RELCDGQLRGVQYSTESLMEEMARADRE 276
EA + E +A + G REL + +L + E ++ A++E
Sbjct: 1627 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1682
Score = 52.4 bits (124), Expect = 6e-07
Identities = 76/273 (27%), Positives = 121/273 (44%), Gaps = 54/273 (19%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL------RRRS 105
Q L + ++ RQ ++E E+L R ++ ES+ Q +L+ R ++ +R
Sbjct: 1444 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1503
Query: 106 QAAQPLQGEAREAAR-------ERAERVRRRLEEAERHKEDLEQHSR--------QLQEQ 150
QA + L+ +A EA R ERA +V+ LE A+R E Q R QL+
Sbjct: 1504 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1563
Query: 151 WEE---LSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKC--ALQ-----EEKLQ 200
+E +QL E ++Q+ E + A + + ELE + K AL+ EE Q
Sbjct: 1564 LQEEHVAVAQLREEAERRAQQQAEAERARE--EAERELERWQLKANEALRLRLQAEEVAQ 1621
Query: 201 QDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG------ 254
Q +L AEA Q++ + R A+E V+ E AE+ + R+L +G
Sbjct: 1622 QKSLAQAEAEK--QKEEAEREARRRGKAEEQAVRQRELAEQ--ELEKQRQLAEGTAQQRL 1677
Query: 255 ----QLRGVQYSTES-------LMEEMARADRE 276
+L ++ TE L EE+AR RE
Sbjct: 1678 AAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1710
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/264 (23%), Positives = 107/264 (40%), Gaps = 29/264 (10%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHL----GSVSTAMAATQELLLQLQKDNRDGRQRKQELEK 74
+ L P+ +PA + G + + T + L Q K + +R +E E+
Sbjct: 1258 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1317
Query: 75 LMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAE 134
L AE ++ E++R L +QA + EA+E + E V RR E A
Sbjct: 1318 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA- 1376
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCAL 194
D +Q R +QE+ + QL E + Q Q AA+ L+ E E+ + L
Sbjct: 1377 ---VDAQQQKRSIQEELQ----QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1429
Query: 195 QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 254
+ + Q+ + E A+ + A+E + + +A EE + + R++ D
Sbjct: 1430 EATERQRGGAE-GELQAL------------RARAEEAEAQKRQAQEEAERLR--RQVQDE 1474
Query: 255 QLRGVQYSTE--SLMEEMARADRE 276
R Q E S ++ A A RE
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAARE 1498
Score = 47.0 bits (110), Expect = 3e-05
Identities = 63/256 (24%), Positives = 121/256 (47%), Gaps = 31/256 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDL-----SERERSLLRRRSQ 106
Q +L QL+ + R+ +E E+ E E+ +++++ S E++ R ++Q
Sbjct: 2041 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2100
Query: 107 AA-QPLQGEAREAARERAERVRRRLE-------EAERHKEDLEQHSRQLQEQWEELSSQL 158
AA + L+ EA + A RA+ + L E E+HK+ EQ RQ + +EL++
Sbjct: 2101 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2160
Query: 159 FYGGEPQSQKSTEQQLAAQLVTLQNE-LELAETKCALQEE----KLQQDALQTAEAWAIF 213
E QK+ L +L L+ E E A + ++EE ++Q + L +A
Sbjct: 2161 LQLEETDHQKNL---LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2217
Query: 214 QEQTVVLQVRPHS------DAKEVQVKVMEAAEELDAWQSG---RELCDGQLRGVQYSTE 264
+ + ++L+ + ++ +A++++ EAA A Q R+L + L + E
Sbjct: 2218 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2277
Query: 265 SLMEEMARADRE-TRL 279
+++E +A +E TRL
Sbjct: 2278 KMLKEKMQAVQEATRL 2293
Score = 46.6 bits (109), Expect = 3e-05
Identities = 65/266 (24%), Positives = 106/266 (39%), Gaps = 56/266 (21%)
Query: 52 QELLLQLQKDNRD-GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR-------- 102
QE +LQ+D +Q +E + R LEAE + ++L+ +E ER LR
Sbjct: 2308 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQ 2364
Query: 103 -RRSQAAQPLQGEARE----------AARER-----------------AERVRRRLEEAE 134
R + AQ + +A E A +E+ AER+R + E E
Sbjct: 2365 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2424
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCAL 194
R KE L+Q ++ LQ + EE+ Q ++QL + LQ L+E L
Sbjct: 2425 REKEKLQQEAKLLQLKSEEM------------QTVQQEQLLQETQALQQSF-LSEKDSLL 2471
Query: 195 QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 254
Q E+ + + A+ +FQ++ Q ++ Q E + + + R
Sbjct: 2472 QRERFIEQ--EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2529
Query: 255 QLRGVQYSTESLME-EMARADRETRL 279
GV+ E L + E R +E L
Sbjct: 2530 AEEGVRRKQEELQQLEQQRRQQEELL 2555
Score = 44.7 bits (104), Expect = 1e-04
Identities = 44/192 (22%), Positives = 88/192 (45%), Gaps = 14/192 (7%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQ 112
E L +L+ + + +++ ++E+ + + + E L++ + R+L+ R Q
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF- 2233
Query: 113 GEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQ 172
+E AE++++ EEA R ++ +R Q E+L+ Q + +K
Sbjct: 2234 ------LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2287
Query: 173 Q----LAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQ---EQTVVLQVRPH 225
Q L A+ LQ + ELA+ + +E +Q A Q AE FQ E Q+
Sbjct: 2288 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2347
Query: 226 SDAKEVQVKVME 237
++A+ ++++V E
Sbjct: 2348 AEAERLKLRVAE 2359
Score = 42.7 bits (99), Expect = 5e-04
Identities = 70/286 (24%), Positives = 118/286 (41%), Gaps = 54/286 (18%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESES---LNQ 88
RL R G V +LL + Q R++ELE+L R L ES L
Sbjct: 1130 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1189
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSR--- 145
LQD RRR + Q + +A RE+ + + LEE ERH E +E+ R
Sbjct: 1190 WLQDA--------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1241
Query: 146 -----------QLQEQWEELSSQLFYGGEPQSQKSTEQQLA---------AQLVTLQNE- 184
QL +L +P+ Q +E + ++L TL ++
Sbjct: 1242 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1301
Query: 185 -------LELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS------DAKEV 231
L E + L E++ ++ + AE A ++Q + + + +AKE+
Sbjct: 1302 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1361
Query: 232 QVKVMEAA---EE--LDAWQSGRELCDGQLRGVQYSTESLMEEMAR 272
Q ++ E EE +DA Q R + + +L+ ++ S+E+ ++ AR
Sbjct: 1362 QQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKAR 1406
Score = 41.6 bits (96), Expect = 0.001
Identities = 41/159 (25%), Positives = 71/159 (44%), Gaps = 11/159 (6%)
Query: 67 QRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERV 126
Q K +LE+L + A++ Q+L++ +R++ + + Q EAR E E V
Sbjct: 2479 QEKAKLEQLFQDEVAKA----QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2534
Query: 127 RRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGE------PQSQKSTEQQLAAQLVT 180
RR+ EE ++ ++ Q L E+ + L QL E S++ T Q+AA T
Sbjct: 2535 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA-TKT 2593
Query: 181 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVV 219
L N + + A E + D L+ + QE ++
Sbjct: 2594 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGIL 2632
Score = 35.4 bits (80), Expect = 0.079
Identities = 42/176 (23%), Positives = 83/176 (47%), Gaps = 23/176 (13%)
Query: 70 QELEKLMRGLEA---ESESLNQRLQDLSERERSL--LRRRSQAAQPLQGEARE---AARE 121
Q E+++R E E++++ L +L + SL LR +++A QP R+ A+E
Sbjct: 1067 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1126
Query: 122 RAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTL 181
ER+++R E + E + QL E+W+ + +Q ++ +QL QL
Sbjct: 1127 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ------TDVRQRELEQLGRQLRYY 1180
Query: 182 QNELELAETKCALQEEKLQQDALQT---AEAWAI----FQEQTVVLQVRPHSDAKE 230
+ + LQ+ + +Q+ +Q A++ A+ QEQ ++ ++ H + E
Sbjct: 1181 RESAD--PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1234
Score = 32.3 bits (72), Expect = 0.67
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q+ + + Q+ + ++++Q++E+ + L A E +R + E +RR+ + Q L
Sbjct: 2489 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG----VRRKQEELQQL 2544
Query: 112 QGEAR---EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
+ + R E E +R+R +L+ E EQH L E +SQ+
Sbjct: 2545 EQQRRQQEELLAEENQRLREQLQLLE------EQHRAALAHSEEVTASQV 2588
Score = 28.9 bits (63), Expect = 7.4
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQE----LEKLMRGLEA----ESESLNQRLQDLSERERS 99
+ A+ E + Q + +G +RKQE LE+ R E E++ L ++LQ L E+ R+
Sbjct: 2516 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2575
Query: 100 LLRRRSQAA--------------QPLQGEAREAARERAERVRRRLEEAERHKE 138
L + L G A EA E + RR A+R +E
Sbjct: 2576 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2628
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 61.6 bits (148), Expect = 1e-09
Identities = 50/203 (24%), Positives = 101/203 (49%), Gaps = 6/203 (2%)
Query: 42 GSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL 101
G+ +AA QEL+ +L+ + G Q++Q LE+ + L+ E+ + Q+ Q+L E E + +
Sbjct: 1840 GTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL-EAELAKV 1897
Query: 102 RRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYG 161
R + + A E +R +E+ ++RLE +L + + +L+ EE Q
Sbjct: 1898 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1957
Query: 162 GEPQSQKSTEQQ--LAAQLVTLQNELEL-AETKCALQEEKLQQDALQTAEAWAIFQEQTV 218
E +++ E + LA +L + L E + AL+E++ + + L+ FQ + +
Sbjct: 1958 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 2017
Query: 219 VLQVRPH-SDAKEVQVKVMEAAE 240
Q H +D +E ++ +A++
Sbjct: 2018 EEQAAQHKADIEERLAQLRKASD 2040
Score = 60.1 bits (144), Expect = 3e-09
Identities = 70/248 (28%), Positives = 113/248 (45%), Gaps = 18/248 (7%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQE--------LEKLMRGLEAESESLNQRLQD-LSERE 97
A+ A +EL LQ ++ R RQ + E LE R EAE +S + ++ E
Sbjct: 1671 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1730
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQ---LQEQWEEL 154
RSL AQ L+ EA A+++AE R R EEAER E + + + L+ Q EE+
Sbjct: 1731 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEV 1788
Query: 155 SSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQE-EKLQQDALQTAEAWAIF 213
+ Q ++ E + A+ E + + + A QE EK +Q A TA+
Sbjct: 1789 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1848
Query: 214 QEQTVVLQVRPHSDAKEVQVKVMEAAE---ELDAWQSGRELCDGQLRGVQYSTESLMEEM 270
+++ + L+ ++ Q+ E A E A R+ + +L V+ E L+
Sbjct: 1849 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1908
Query: 271 ARADRETR 278
ARA+ E+R
Sbjct: 1909 ARAEEESR 1916
Score = 55.8 bits (133), Expect = 6e-08
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 33/261 (12%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR-LQDLSERERSLL 101
S A A EL L+L GR R + L +AE E+ QR L ER R
Sbjct: 2070 SFEKAAAGKAELELEL------GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2123
Query: 102 RRRSQAAQPLQGEA---REAARERAERVRRRLEEAERHKEDLEQHS-RQLQ--------- 148
R Q + + EA R+AA E ER++ ++EEA R +E EQ S RQLQ
Sbjct: 2124 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2183
Query: 149 EQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEE-------KLQQ 201
Q EE + + Q + T QQ + L L+ E E A EE + Q
Sbjct: 2184 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2243
Query: 202 DALQTAEAWAIFQEQTVVLQVRPHSDA------KEVQVKVMEAAEELDAWQSGRELCDGQ 255
Q EA + Q Q R + A KE + + A+ A ++ D +
Sbjct: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2303
Query: 256 LRGVQYSTESLMEEMARADRE 276
+ + E + + A+ ++E
Sbjct: 2304 MEKHKKFAEQTLRQKAQVEQE 2324
Score = 52.8 bits (125), Expect = 5e-07
Identities = 55/236 (23%), Positives = 105/236 (44%), Gaps = 25/236 (10%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERER-------SLLRRRSQAAQPLQG--EAR 116
R R +E E R + E+E L +++QD S+R+R S ++ ++AA+ Q +A
Sbjct: 1616 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1675
Query: 117 EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAA 176
E R +AE RRL +AE + Q + + ++ E Q + E+ L
Sbjct: 1676 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1735
Query: 177 QLVTLQNELELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVK 234
+ V + E AE + Q E+ +++A + E W + + + L+++ A++ +
Sbjct: 1736 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1795
Query: 235 VMEAAE-----ELDAWQSG---------RELCDGQLRGVQYSTESLMEEMARADRE 276
EA + E +A + G REL + +L + E ++ A++E
Sbjct: 1796 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1851
Score = 52.4 bits (124), Expect = 6e-07
Identities = 76/273 (27%), Positives = 121/273 (44%), Gaps = 54/273 (19%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL------RRRS 105
Q L + ++ RQ ++E E+L R ++ ES+ Q +L+ R ++ +R
Sbjct: 1613 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1672
Query: 106 QAAQPLQGEAREAAR-------ERAERVRRRLEEAERHKEDLEQHSR--------QLQEQ 150
QA + L+ +A EA R ERA +V+ LE A+R E Q R QL+
Sbjct: 1673 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1732
Query: 151 WEE---LSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKC--ALQ-----EEKLQ 200
+E +QL E ++Q+ E + A + + ELE + K AL+ EE Q
Sbjct: 1733 LQEEHVAVAQLREEAERRAQQQAEAERARE--EAERELERWQLKANEALRLRLQAEEVAQ 1790
Query: 201 QDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG------ 254
Q +L AEA Q++ + R A+E V+ E AE+ + R+L +G
Sbjct: 1791 QKSLAQAEAEK--QKEEAEREARRRGKAEEQAVRQRELAEQ--ELEKQRQLAEGTAQQRL 1846
Query: 255 ----QLRGVQYSTES-------LMEEMARADRE 276
+L ++ TE L EE+AR RE
Sbjct: 1847 AAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1879
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/264 (23%), Positives = 107/264 (40%), Gaps = 29/264 (10%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHL----GSVSTAMAATQELLLQLQKDNRDGRQRKQELEK 74
+ L P+ +PA + G + + T + L Q K + +R +E E+
Sbjct: 1427 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1486
Query: 75 LMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAE 134
L AE ++ E++R L +QA + EA+E + E V RR E A
Sbjct: 1487 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA- 1545
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCAL 194
D +Q R +QE+ + QL E + Q Q AA+ L+ E E+ + L
Sbjct: 1546 ---VDAQQQKRSIQEELQ----QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1598
Query: 195 QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 254
+ + Q+ + E A+ + A+E + + +A EE + + R++ D
Sbjct: 1599 EATERQRGGAE-GELQAL------------RARAEEAEAQKRQAQEEAERLR--RQVQDE 1643
Query: 255 QLRGVQYSTE--SLMEEMARADRE 276
R Q E S ++ A A RE
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAARE 1667
Score = 47.0 bits (110), Expect = 3e-05
Identities = 63/256 (24%), Positives = 121/256 (47%), Gaps = 31/256 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDL-----SERERSLLRRRSQ 106
Q +L QL+ + R+ +E E+ E E+ +++++ S E++ R ++Q
Sbjct: 2210 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2269
Query: 107 AA-QPLQGEAREAARERAERVRRRLE-------EAERHKEDLEQHSRQLQEQWEELSSQL 158
AA + L+ EA + A RA+ + L E E+HK+ EQ RQ + +EL++
Sbjct: 2270 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2329
Query: 159 FYGGEPQSQKSTEQQLAAQLVTLQNE-LELAETKCALQEE----KLQQDALQTAEAWAIF 213
E QK+ L +L L+ E E A + ++EE ++Q + L +A
Sbjct: 2330 LQLEETDHQKNL---LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2386
Query: 214 QEQTVVLQVRPHS------DAKEVQVKVMEAAEELDAWQSG---RELCDGQLRGVQYSTE 264
+ + ++L+ + ++ +A++++ EAA A Q R+L + L + E
Sbjct: 2387 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2446
Query: 265 SLMEEMARADRE-TRL 279
+++E +A +E TRL
Sbjct: 2447 KMLKEKMQAVQEATRL 2462
Score = 46.6 bits (109), Expect = 3e-05
Identities = 65/266 (24%), Positives = 106/266 (39%), Gaps = 56/266 (21%)
Query: 52 QELLLQLQKDNRD-GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR-------- 102
QE +LQ+D +Q +E + R LEAE + ++L+ +E ER LR
Sbjct: 2477 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQ 2533
Query: 103 -RRSQAAQPLQGEARE----------AARER-----------------AERVRRRLEEAE 134
R + AQ + +A E A +E+ AER+R + E E
Sbjct: 2534 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCAL 194
R KE L+Q ++ LQ + EE+ Q ++QL + LQ L+E L
Sbjct: 2594 REKEKLQQEAKLLQLKSEEM------------QTVQQEQLLQETQALQQSF-LSEKDSLL 2640
Query: 195 QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 254
Q E+ + + A+ +FQ++ Q ++ Q E + + + R
Sbjct: 2641 QRERFIEQ--EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2698
Query: 255 QLRGVQYSTESLME-EMARADRETRL 279
GV+ E L + E R +E L
Sbjct: 2699 AEEGVRRKQEELQQLEQQRRQQEELL 2724
Score = 44.7 bits (104), Expect = 1e-04
Identities = 44/192 (22%), Positives = 88/192 (45%), Gaps = 14/192 (7%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQ 112
E L +L+ + + +++ ++E+ + + + E L++ + R+L+ R Q
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF- 2402
Query: 113 GEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQ 172
+E AE++++ EEA R ++ +R Q E+L+ Q + +K
Sbjct: 2403 ------LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2456
Query: 173 Q----LAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQ---EQTVVLQVRPH 225
Q L A+ LQ + ELA+ + +E +Q A Q AE FQ E Q+
Sbjct: 2457 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2516
Query: 226 SDAKEVQVKVME 237
++A+ ++++V E
Sbjct: 2517 AEAERLKLRVAE 2528
Score = 42.7 bits (99), Expect = 5e-04
Identities = 70/286 (24%), Positives = 118/286 (41%), Gaps = 54/286 (18%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESES---LNQ 88
RL R G V +LL + Q R++ELE+L R L ES L
Sbjct: 1299 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1358
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSR--- 145
LQD RRR + Q + +A RE+ + + LEE ERH E +E+ R
Sbjct: 1359 WLQDA--------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1410
Query: 146 -----------QLQEQWEELSSQLFYGGEPQSQKSTEQQLA---------AQLVTLQNE- 184
QL +L +P+ Q +E + ++L TL ++
Sbjct: 1411 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1470
Query: 185 -------LELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS------DAKEV 231
L E + L E++ ++ + AE A ++Q + + + +AKE+
Sbjct: 1471 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1530
Query: 232 QVKVMEAA---EE--LDAWQSGRELCDGQLRGVQYSTESLMEEMAR 272
Q ++ E EE +DA Q R + + +L+ ++ S+E+ ++ AR
Sbjct: 1531 QQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKAR 1575
Score = 41.6 bits (96), Expect = 0.001
Identities = 41/159 (25%), Positives = 71/159 (44%), Gaps = 11/159 (6%)
Query: 67 QRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERV 126
Q K +LE+L + A++ Q+L++ +R++ + + Q EAR E E V
Sbjct: 2648 QEKAKLEQLFQDEVAKA----QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2703
Query: 127 RRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGE------PQSQKSTEQQLAAQLVT 180
RR+ EE ++ ++ Q L E+ + L QL E S++ T Q+AA T
Sbjct: 2704 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA-TKT 2762
Query: 181 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVV 219
L N + + A E + D L+ + QE ++
Sbjct: 2763 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGIL 2801
Score = 35.4 bits (80), Expect = 0.079
Identities = 42/176 (23%), Positives = 83/176 (47%), Gaps = 23/176 (13%)
Query: 70 QELEKLMRGLEA---ESESLNQRLQDLSERERSL--LRRRSQAAQPLQGEARE---AARE 121
Q E+++R E E++++ L +L + SL LR +++A QP R+ A+E
Sbjct: 1236 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1295
Query: 122 RAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTL 181
ER+++R E + E + QL E+W+ + +Q ++ +QL QL
Sbjct: 1296 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ------TDVRQRELEQLGRQLRYY 1349
Query: 182 QNELELAETKCALQEEKLQQDALQT---AEAWAI----FQEQTVVLQVRPHSDAKE 230
+ + LQ+ + +Q+ +Q A++ A+ QEQ ++ ++ H + E
Sbjct: 1350 RESAD--PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1403
Score = 32.3 bits (72), Expect = 0.67
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q+ + + Q+ + ++++Q++E+ + L A E +R + E +RR+ + Q L
Sbjct: 2658 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG----VRRKQEELQQL 2713
Query: 112 QGEAR---EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
+ + R E E +R+R +L+ E EQH L E +SQ+
Sbjct: 2714 EQQRRQQEELLAEENQRLREQLQLLE------EQHRAALAHSEEVTASQV 2757
Score = 28.9 bits (63), Expect = 7.4
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQE----LEKLMRGLEA----ESESLNQRLQDLSERERS 99
+ A+ E + Q + +G +RKQE LE+ R E E++ L ++LQ L E+ R+
Sbjct: 2685 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2744
Query: 100 LLRRRSQAA--------------QPLQGEAREAARERAERVRRRLEEAERHKE 138
L + L G A EA E + RR A+R +E
Sbjct: 2745 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2797
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 61.6 bits (148), Expect = 1e-09
Identities = 50/203 (24%), Positives = 101/203 (49%), Gaps = 6/203 (2%)
Query: 42 GSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL 101
G+ +AA QEL+ +L+ + G Q++Q LE+ + L+ E+ + Q+ Q+L E E + +
Sbjct: 1681 GTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL-EAELAKV 1738
Query: 102 RRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYG 161
R + + A E +R +E+ ++RLE +L + + +L+ EE Q
Sbjct: 1739 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1798
Query: 162 GEPQSQKSTEQQ--LAAQLVTLQNELEL-AETKCALQEEKLQQDALQTAEAWAIFQEQTV 218
E +++ E + LA +L + L E + AL+E++ + + L+ FQ + +
Sbjct: 1799 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1858
Query: 219 VLQVRPH-SDAKEVQVKVMEAAE 240
Q H +D +E ++ +A++
Sbjct: 1859 EEQAAQHKADIEERLAQLRKASD 1881
Score = 60.1 bits (144), Expect = 3e-09
Identities = 70/248 (28%), Positives = 113/248 (45%), Gaps = 18/248 (7%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQE--------LEKLMRGLEAESESLNQRLQD-LSERE 97
A+ A +EL LQ ++ R RQ + E LE R EAE +S + ++ E
Sbjct: 1512 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1571
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQ---LQEQWEEL 154
RSL AQ L+ EA A+++AE R R EEAER E + + + L+ Q EE+
Sbjct: 1572 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEV 1629
Query: 155 SSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQE-EKLQQDALQTAEAWAIF 213
+ Q ++ E + A+ E + + + A QE EK +Q A TA+
Sbjct: 1630 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1689
Query: 214 QEQTVVLQVRPHSDAKEVQVKVMEAAE---ELDAWQSGRELCDGQLRGVQYSTESLMEEM 270
+++ + L+ ++ Q+ E A E A R+ + +L V+ E L+
Sbjct: 1690 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1749
Query: 271 ARADRETR 278
ARA+ E+R
Sbjct: 1750 ARAEEESR 1757
Score = 55.8 bits (133), Expect = 6e-08
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 33/261 (12%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR-LQDLSERERSLL 101
S A A EL L+L GR R + L +AE E+ QR L ER R
Sbjct: 1911 SFEKAAAGKAELELEL------GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1964
Query: 102 RRRSQAAQPLQGEA---REAARERAERVRRRLEEAERHKEDLEQHS-RQLQ--------- 148
R Q + + EA R+AA E ER++ ++EEA R +E EQ S RQLQ
Sbjct: 1965 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2024
Query: 149 EQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEE-------KLQQ 201
Q EE + + Q + T QQ + L L+ E E A EE + Q
Sbjct: 2025 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2084
Query: 202 DALQTAEAWAIFQEQTVVLQVRPHSDA------KEVQVKVMEAAEELDAWQSGRELCDGQ 255
Q EA + Q Q R + A KE + + A+ A ++ D +
Sbjct: 2085 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2144
Query: 256 LRGVQYSTESLMEEMARADRE 276
+ + E + + A+ ++E
Sbjct: 2145 MEKHKKFAEQTLRQKAQVEQE 2165
Score = 52.8 bits (125), Expect = 5e-07
Identities = 55/236 (23%), Positives = 105/236 (44%), Gaps = 25/236 (10%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERER-------SLLRRRSQAAQPLQG--EAR 116
R R +E E R + E+E L +++QD S+R+R S ++ ++AA+ Q +A
Sbjct: 1457 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1516
Query: 117 EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAA 176
E R +AE RRL +AE + Q + + ++ E Q + E+ L
Sbjct: 1517 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1576
Query: 177 QLVTLQNELELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVK 234
+ V + E AE + Q E+ +++A + E W + + + L+++ A++ +
Sbjct: 1577 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1636
Query: 235 VMEAAE-----ELDAWQSG---------RELCDGQLRGVQYSTESLMEEMARADRE 276
EA + E +A + G REL + +L + E ++ A++E
Sbjct: 1637 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1692
Score = 52.4 bits (124), Expect = 6e-07
Identities = 76/273 (27%), Positives = 121/273 (44%), Gaps = 54/273 (19%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL------RRRS 105
Q L + ++ RQ ++E E+L R ++ ES+ Q +L+ R ++ +R
Sbjct: 1454 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1513
Query: 106 QAAQPLQGEAREAAR-------ERAERVRRRLEEAERHKEDLEQHSR--------QLQEQ 150
QA + L+ +A EA R ERA +V+ LE A+R E Q R QL+
Sbjct: 1514 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1573
Query: 151 WEE---LSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKC--ALQ-----EEKLQ 200
+E +QL E ++Q+ E + A + + ELE + K AL+ EE Q
Sbjct: 1574 LQEEHVAVAQLREEAERRAQQQAEAERARE--EAERELERWQLKANEALRLRLQAEEVAQ 1631
Query: 201 QDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG------ 254
Q +L AEA Q++ + R A+E V+ E AE+ + R+L +G
Sbjct: 1632 QKSLAQAEAEK--QKEEAEREARRRGKAEEQAVRQRELAEQ--ELEKQRQLAEGTAQQRL 1687
Query: 255 ----QLRGVQYSTES-------LMEEMARADRE 276
+L ++ TE L EE+AR RE
Sbjct: 1688 AAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1720
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/264 (23%), Positives = 107/264 (40%), Gaps = 29/264 (10%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHL----GSVSTAMAATQELLLQLQKDNRDGRQRKQELEK 74
+ L P+ +PA + G + + T + L Q K + +R +E E+
Sbjct: 1268 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1327
Query: 75 LMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAE 134
L AE ++ E++R L +QA + EA+E + E V RR E A
Sbjct: 1328 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA- 1386
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCAL 194
D +Q R +QE+ + QL E + Q Q AA+ L+ E E+ + L
Sbjct: 1387 ---VDAQQQKRSIQEELQ----QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1439
Query: 195 QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 254
+ + Q+ + E A+ + A+E + + +A EE + + R++ D
Sbjct: 1440 EATERQRGGAE-GELQAL------------RARAEEAEAQKRQAQEEAERLR--RQVQDE 1484
Query: 255 QLRGVQYSTE--SLMEEMARADRE 276
R Q E S ++ A A RE
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAARE 1508
Score = 47.0 bits (110), Expect = 3e-05
Identities = 63/256 (24%), Positives = 121/256 (47%), Gaps = 31/256 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDL-----SERERSLLRRRSQ 106
Q +L QL+ + R+ +E E+ E E+ +++++ S E++ R ++Q
Sbjct: 2051 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2110
Query: 107 AA-QPLQGEAREAARERAERVRRRLE-------EAERHKEDLEQHSRQLQEQWEELSSQL 158
AA + L+ EA + A RA+ + L E E+HK+ EQ RQ + +EL++
Sbjct: 2111 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2170
Query: 159 FYGGEPQSQKSTEQQLAAQLVTLQNE-LELAETKCALQEE----KLQQDALQTAEAWAIF 213
E QK+ L +L L+ E E A + ++EE ++Q + L +A
Sbjct: 2171 LQLEETDHQKNL---LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2227
Query: 214 QEQTVVLQVRPHS------DAKEVQVKVMEAAEELDAWQSG---RELCDGQLRGVQYSTE 264
+ + ++L+ + ++ +A++++ EAA A Q R+L + L + E
Sbjct: 2228 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2287
Query: 265 SLMEEMARADRE-TRL 279
+++E +A +E TRL
Sbjct: 2288 KMLKEKMQAVQEATRL 2303
Score = 46.6 bits (109), Expect = 3e-05
Identities = 65/266 (24%), Positives = 106/266 (39%), Gaps = 56/266 (21%)
Query: 52 QELLLQLQKDNRD-GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR-------- 102
QE +LQ+D +Q +E + R LEAE + ++L+ +E ER LR
Sbjct: 2318 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQ 2374
Query: 103 -RRSQAAQPLQGEARE----------AARER-----------------AERVRRRLEEAE 134
R + AQ + +A E A +E+ AER+R + E E
Sbjct: 2375 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2434
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCAL 194
R KE L+Q ++ LQ + EE+ Q ++QL + LQ L+E L
Sbjct: 2435 REKEKLQQEAKLLQLKSEEM------------QTVQQEQLLQETQALQQSF-LSEKDSLL 2481
Query: 195 QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 254
Q E+ + + A+ +FQ++ Q ++ Q E + + + R
Sbjct: 2482 QRERFIEQ--EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2539
Query: 255 QLRGVQYSTESLME-EMARADRETRL 279
GV+ E L + E R +E L
Sbjct: 2540 AEEGVRRKQEELQQLEQQRRQQEELL 2565
Score = 44.7 bits (104), Expect = 1e-04
Identities = 44/192 (22%), Positives = 88/192 (45%), Gaps = 14/192 (7%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQ 112
E L +L+ + + +++ ++E+ + + + E L++ + R+L+ R Q
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF- 2243
Query: 113 GEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQ 172
+E AE++++ EEA R ++ +R Q E+L+ Q + +K
Sbjct: 2244 ------LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2297
Query: 173 Q----LAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQ---EQTVVLQVRPH 225
Q L A+ LQ + ELA+ + +E +Q A Q AE FQ E Q+
Sbjct: 2298 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2357
Query: 226 SDAKEVQVKVME 237
++A+ ++++V E
Sbjct: 2358 AEAERLKLRVAE 2369
Score = 42.7 bits (99), Expect = 5e-04
Identities = 70/286 (24%), Positives = 118/286 (41%), Gaps = 54/286 (18%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESES---LNQ 88
RL R G V +LL + Q R++ELE+L R L ES L
Sbjct: 1140 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1199
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSR--- 145
LQD RRR + Q + +A RE+ + + LEE ERH E +E+ R
Sbjct: 1200 WLQDA--------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1251
Query: 146 -----------QLQEQWEELSSQLFYGGEPQSQKSTEQQLA---------AQLVTLQNE- 184
QL +L +P+ Q +E + ++L TL ++
Sbjct: 1252 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1311
Query: 185 -------LELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS------DAKEV 231
L E + L E++ ++ + AE A ++Q + + + +AKE+
Sbjct: 1312 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1371
Query: 232 QVKVMEAA---EE--LDAWQSGRELCDGQLRGVQYSTESLMEEMAR 272
Q ++ E EE +DA Q R + + +L+ ++ S+E+ ++ AR
Sbjct: 1372 QQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKAR 1416
Score = 41.6 bits (96), Expect = 0.001
Identities = 41/159 (25%), Positives = 71/159 (44%), Gaps = 11/159 (6%)
Query: 67 QRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERV 126
Q K +LE+L + A++ Q+L++ +R++ + + Q EAR E E V
Sbjct: 2489 QEKAKLEQLFQDEVAKA----QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2544
Query: 127 RRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGE------PQSQKSTEQQLAAQLVT 180
RR+ EE ++ ++ Q L E+ + L QL E S++ T Q+AA T
Sbjct: 2545 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA-TKT 2603
Query: 181 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVV 219
L N + + A E + D L+ + QE ++
Sbjct: 2604 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGIL 2642
Score = 35.4 bits (80), Expect = 0.079
Identities = 42/176 (23%), Positives = 83/176 (47%), Gaps = 23/176 (13%)
Query: 70 QELEKLMRGLEA---ESESLNQRLQDLSERERSL--LRRRSQAAQPLQGEARE---AARE 121
Q E+++R E E++++ L +L + SL LR +++A QP R+ A+E
Sbjct: 1077 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1136
Query: 122 RAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTL 181
ER+++R E + E + QL E+W+ + +Q ++ +QL QL
Sbjct: 1137 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ------TDVRQRELEQLGRQLRYY 1190
Query: 182 QNELELAETKCALQEEKLQQDALQT---AEAWAI----FQEQTVVLQVRPHSDAKE 230
+ + LQ+ + +Q+ +Q A++ A+ QEQ ++ ++ H + E
Sbjct: 1191 RESAD--PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1244
Score = 32.3 bits (72), Expect = 0.67
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q+ + + Q+ + ++++Q++E+ + L A E +R + E +RR+ + Q L
Sbjct: 2499 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG----VRRKQEELQQL 2554
Query: 112 QGEAR---EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
+ + R E E +R+R +L+ E EQH L E +SQ+
Sbjct: 2555 EQQRRQQEELLAEENQRLREQLQLLE------EQHRAALAHSEEVTASQV 2598
Score = 28.9 bits (63), Expect = 7.4
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQE----LEKLMRGLEA----ESESLNQRLQDLSERERS 99
+ A+ E + Q + +G +RKQE LE+ R E E++ L ++LQ L E+ R+
Sbjct: 2526 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2585
Query: 100 LLRRRSQAA--------------QPLQGEAREAARERAERVRRRLEEAERHKE 138
L + L G A EA E + RR A+R +E
Sbjct: 2586 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2638
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 61.6 bits (148), Expect = 1e-09
Identities = 50/203 (24%), Positives = 101/203 (49%), Gaps = 6/203 (2%)
Query: 42 GSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL 101
G+ +AA QEL+ +L+ + G Q++Q LE+ + L+ E+ + Q+ Q+L E E + +
Sbjct: 1689 GTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL-EAELAKV 1746
Query: 102 RRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYG 161
R + + A E +R +E+ ++RLE +L + + +L+ EE Q
Sbjct: 1747 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1806
Query: 162 GEPQSQKSTEQQ--LAAQLVTLQNELEL-AETKCALQEEKLQQDALQTAEAWAIFQEQTV 218
E +++ E + LA +L + L E + AL+E++ + + L+ FQ + +
Sbjct: 1807 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1866
Query: 219 VLQVRPH-SDAKEVQVKVMEAAE 240
Q H +D +E ++ +A++
Sbjct: 1867 EEQAAQHKADIEERLAQLRKASD 1889
Score = 60.1 bits (144), Expect = 3e-09
Identities = 70/248 (28%), Positives = 113/248 (45%), Gaps = 18/248 (7%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQE--------LEKLMRGLEAESESLNQRLQD-LSERE 97
A+ A +EL LQ ++ R RQ + E LE R EAE +S + ++ E
Sbjct: 1520 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1579
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQ---LQEQWEEL 154
RSL AQ L+ EA A+++AE R R EEAER E + + + L+ Q EE+
Sbjct: 1580 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEV 1637
Query: 155 SSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQE-EKLQQDALQTAEAWAIF 213
+ Q ++ E + A+ E + + + A QE EK +Q A TA+
Sbjct: 1638 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1697
Query: 214 QEQTVVLQVRPHSDAKEVQVKVMEAAE---ELDAWQSGRELCDGQLRGVQYSTESLMEEM 270
+++ + L+ ++ Q+ E A E A R+ + +L V+ E L+
Sbjct: 1698 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1757
Query: 271 ARADRETR 278
ARA+ E+R
Sbjct: 1758 ARAEEESR 1765
Score = 55.8 bits (133), Expect = 6e-08
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 33/261 (12%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR-LQDLSERERSLL 101
S A A EL L+L GR R + L +AE E+ QR L ER R
Sbjct: 1919 SFEKAAAGKAELELEL------GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1972
Query: 102 RRRSQAAQPLQGEA---REAARERAERVRRRLEEAERHKEDLEQHS-RQLQ--------- 148
R Q + + EA R+AA E ER++ ++EEA R +E EQ S RQLQ
Sbjct: 1973 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2032
Query: 149 EQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEE-------KLQQ 201
Q EE + + Q + T QQ + L L+ E E A EE + Q
Sbjct: 2033 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2092
Query: 202 DALQTAEAWAIFQEQTVVLQVRPHSDA------KEVQVKVMEAAEELDAWQSGRELCDGQ 255
Q EA + Q Q R + A KE + + A+ A ++ D +
Sbjct: 2093 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2152
Query: 256 LRGVQYSTESLMEEMARADRE 276
+ + E + + A+ ++E
Sbjct: 2153 MEKHKKFAEQTLRQKAQVEQE 2173
Score = 52.8 bits (125), Expect = 5e-07
Identities = 55/236 (23%), Positives = 105/236 (44%), Gaps = 25/236 (10%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERER-------SLLRRRSQAAQPLQG--EAR 116
R R +E E R + E+E L +++QD S+R+R S ++ ++AA+ Q +A
Sbjct: 1465 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1524
Query: 117 EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAA 176
E R +AE RRL +AE + Q + + ++ E Q + E+ L
Sbjct: 1525 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1584
Query: 177 QLVTLQNELELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVK 234
+ V + E AE + Q E+ +++A + E W + + + L+++ A++ +
Sbjct: 1585 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1644
Query: 235 VMEAAE-----ELDAWQSG---------RELCDGQLRGVQYSTESLMEEMARADRE 276
EA + E +A + G REL + +L + E ++ A++E
Sbjct: 1645 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1700
Score = 52.4 bits (124), Expect = 6e-07
Identities = 76/273 (27%), Positives = 121/273 (44%), Gaps = 54/273 (19%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL------RRRS 105
Q L + ++ RQ ++E E+L R ++ ES+ Q +L+ R ++ +R
Sbjct: 1462 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1521
Query: 106 QAAQPLQGEAREAAR-------ERAERVRRRLEEAERHKEDLEQHSR--------QLQEQ 150
QA + L+ +A EA R ERA +V+ LE A+R E Q R QL+
Sbjct: 1522 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1581
Query: 151 WEE---LSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKC--ALQ-----EEKLQ 200
+E +QL E ++Q+ E + A + + ELE + K AL+ EE Q
Sbjct: 1582 LQEEHVAVAQLREEAERRAQQQAEAERARE--EAERELERWQLKANEALRLRLQAEEVAQ 1639
Query: 201 QDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG------ 254
Q +L AEA Q++ + R A+E V+ E AE+ + R+L +G
Sbjct: 1640 QKSLAQAEAEK--QKEEAEREARRRGKAEEQAVRQRELAEQ--ELEKQRQLAEGTAQQRL 1695
Query: 255 ----QLRGVQYSTES-------LMEEMARADRE 276
+L ++ TE L EE+AR RE
Sbjct: 1696 AAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1728
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/264 (23%), Positives = 107/264 (40%), Gaps = 29/264 (10%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHL----GSVSTAMAATQELLLQLQKDNRDGRQRKQELEK 74
+ L P+ +PA + G + + T + L Q K + +R +E E+
Sbjct: 1276 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1335
Query: 75 LMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAE 134
L AE ++ E++R L +QA + EA+E + E V RR E A
Sbjct: 1336 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA- 1394
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCAL 194
D +Q R +QE+ + QL E + Q Q AA+ L+ E E+ + L
Sbjct: 1395 ---VDAQQQKRSIQEELQ----QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1447
Query: 195 QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 254
+ + Q+ + E A+ + A+E + + +A EE + + R++ D
Sbjct: 1448 EATERQRGGAE-GELQAL------------RARAEEAEAQKRQAQEEAERLR--RQVQDE 1492
Query: 255 QLRGVQYSTE--SLMEEMARADRE 276
R Q E S ++ A A RE
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAARE 1516
Score = 47.0 bits (110), Expect = 3e-05
Identities = 63/256 (24%), Positives = 121/256 (47%), Gaps = 31/256 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDL-----SERERSLLRRRSQ 106
Q +L QL+ + R+ +E E+ E E+ +++++ S E++ R ++Q
Sbjct: 2059 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2118
Query: 107 AA-QPLQGEAREAARERAERVRRRLE-------EAERHKEDLEQHSRQLQEQWEELSSQL 158
AA + L+ EA + A RA+ + L E E+HK+ EQ RQ + +EL++
Sbjct: 2119 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2178
Query: 159 FYGGEPQSQKSTEQQLAAQLVTLQNE-LELAETKCALQEE----KLQQDALQTAEAWAIF 213
E QK+ L +L L+ E E A + ++EE ++Q + L +A
Sbjct: 2179 LQLEETDHQKNL---LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2235
Query: 214 QEQTVVLQVRPHS------DAKEVQVKVMEAAEELDAWQSG---RELCDGQLRGVQYSTE 264
+ + ++L+ + ++ +A++++ EAA A Q R+L + L + E
Sbjct: 2236 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2295
Query: 265 SLMEEMARADRE-TRL 279
+++E +A +E TRL
Sbjct: 2296 KMLKEKMQAVQEATRL 2311
Score = 46.6 bits (109), Expect = 3e-05
Identities = 65/266 (24%), Positives = 106/266 (39%), Gaps = 56/266 (21%)
Query: 52 QELLLQLQKDNRD-GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR-------- 102
QE +LQ+D +Q +E + R LEAE + ++L+ +E ER LR
Sbjct: 2326 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQ 2382
Query: 103 -RRSQAAQPLQGEARE----------AARER-----------------AERVRRRLEEAE 134
R + AQ + +A E A +E+ AER+R + E E
Sbjct: 2383 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2442
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCAL 194
R KE L+Q ++ LQ + EE+ Q ++QL + LQ L+E L
Sbjct: 2443 REKEKLQQEAKLLQLKSEEM------------QTVQQEQLLQETQALQQSF-LSEKDSLL 2489
Query: 195 QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 254
Q E+ + + A+ +FQ++ Q ++ Q E + + + R
Sbjct: 2490 QRERFIEQ--EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2547
Query: 255 QLRGVQYSTESLME-EMARADRETRL 279
GV+ E L + E R +E L
Sbjct: 2548 AEEGVRRKQEELQQLEQQRRQQEELL 2573
Score = 44.7 bits (104), Expect = 1e-04
Identities = 44/192 (22%), Positives = 88/192 (45%), Gaps = 14/192 (7%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQ 112
E L +L+ + + +++ ++E+ + + + E L++ + R+L+ R Q
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF- 2251
Query: 113 GEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQ 172
+E AE++++ EEA R ++ +R Q E+L+ Q + +K
Sbjct: 2252 ------LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2305
Query: 173 Q----LAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQ---EQTVVLQVRPH 225
Q L A+ LQ + ELA+ + +E +Q A Q AE FQ E Q+
Sbjct: 2306 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2365
Query: 226 SDAKEVQVKVME 237
++A+ ++++V E
Sbjct: 2366 AEAERLKLRVAE 2377
Score = 42.7 bits (99), Expect = 5e-04
Identities = 70/286 (24%), Positives = 118/286 (41%), Gaps = 54/286 (18%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESES---LNQ 88
RL R G V +LL + Q R++ELE+L R L ES L
Sbjct: 1148 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1207
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSR--- 145
LQD RRR + Q + +A RE+ + + LEE ERH E +E+ R
Sbjct: 1208 WLQDA--------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1259
Query: 146 -----------QLQEQWEELSSQLFYGGEPQSQKSTEQQLA---------AQLVTLQNE- 184
QL +L +P+ Q +E + ++L TL ++
Sbjct: 1260 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1319
Query: 185 -------LELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS------DAKEV 231
L E + L E++ ++ + AE A ++Q + + + +AKE+
Sbjct: 1320 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1379
Query: 232 QVKVMEAA---EE--LDAWQSGRELCDGQLRGVQYSTESLMEEMAR 272
Q ++ E EE +DA Q R + + +L+ ++ S+E+ ++ AR
Sbjct: 1380 QQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKAR 1424
Score = 41.6 bits (96), Expect = 0.001
Identities = 41/159 (25%), Positives = 71/159 (44%), Gaps = 11/159 (6%)
Query: 67 QRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERV 126
Q K +LE+L + A++ Q+L++ +R++ + + Q EAR E E V
Sbjct: 2497 QEKAKLEQLFQDEVAKA----QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2552
Query: 127 RRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGE------PQSQKSTEQQLAAQLVT 180
RR+ EE ++ ++ Q L E+ + L QL E S++ T Q+AA T
Sbjct: 2553 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA-TKT 2611
Query: 181 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVV 219
L N + + A E + D L+ + QE ++
Sbjct: 2612 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGIL 2650
Score = 35.4 bits (80), Expect = 0.079
Identities = 42/176 (23%), Positives = 83/176 (47%), Gaps = 23/176 (13%)
Query: 70 QELEKLMRGLEA---ESESLNQRLQDLSERERSL--LRRRSQAAQPLQGEARE---AARE 121
Q E+++R E E++++ L +L + SL LR +++A QP R+ A+E
Sbjct: 1085 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1144
Query: 122 RAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTL 181
ER+++R E + E + QL E+W+ + +Q ++ +QL QL
Sbjct: 1145 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ------TDVRQRELEQLGRQLRYY 1198
Query: 182 QNELELAETKCALQEEKLQQDALQT---AEAWAI----FQEQTVVLQVRPHSDAKE 230
+ + LQ+ + +Q+ +Q A++ A+ QEQ ++ ++ H + E
Sbjct: 1199 RESAD--PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1252
Score = 32.3 bits (72), Expect = 0.67
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q+ + + Q+ + ++++Q++E+ + L A E +R + E +RR+ + Q L
Sbjct: 2507 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG----VRRKQEELQQL 2562
Query: 112 QGEAR---EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
+ + R E E +R+R +L+ E EQH L E +SQ+
Sbjct: 2563 EQQRRQQEELLAEENQRLREQLQLLE------EQHRAALAHSEEVTASQV 2606
Score = 28.9 bits (63), Expect = 7.4
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQE----LEKLMRGLEA----ESESLNQRLQDLSERERS 99
+ A+ E + Q + +G +RKQE LE+ R E E++ L ++LQ L E+ R+
Sbjct: 2534 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2593
Query: 100 LLRRRSQAA--------------QPLQGEAREAARERAERVRRRLEEAERHKE 138
L + L G A EA E + RR A+R +E
Sbjct: 2594 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2646
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 61.6 bits (148), Expect = 1e-09
Identities = 50/203 (24%), Positives = 101/203 (49%), Gaps = 6/203 (2%)
Query: 42 GSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL 101
G+ +AA QEL+ +L+ + G Q++Q LE+ + L+ E+ + Q+ Q+L E E + +
Sbjct: 1730 GTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL-EAELAKV 1787
Query: 102 RRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYG 161
R + + A E +R +E+ ++RLE +L + + +L+ EE Q
Sbjct: 1788 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1847
Query: 162 GEPQSQKSTEQQ--LAAQLVTLQNELEL-AETKCALQEEKLQQDALQTAEAWAIFQEQTV 218
E +++ E + LA +L + L E + AL+E++ + + L+ FQ + +
Sbjct: 1848 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1907
Query: 219 VLQVRPH-SDAKEVQVKVMEAAE 240
Q H +D +E ++ +A++
Sbjct: 1908 EEQAAQHKADIEERLAQLRKASD 1930
Score = 60.1 bits (144), Expect = 3e-09
Identities = 70/248 (28%), Positives = 113/248 (45%), Gaps = 18/248 (7%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQE--------LEKLMRGLEAESESLNQRLQD-LSERE 97
A+ A +EL LQ ++ R RQ + E LE R EAE +S + ++ E
Sbjct: 1561 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQ---LQEQWEEL 154
RSL AQ L+ EA A+++AE R R EEAER E + + + L+ Q EE+
Sbjct: 1621 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEV 1678
Query: 155 SSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQE-EKLQQDALQTAEAWAIF 213
+ Q ++ E + A+ E + + + A QE EK +Q A TA+
Sbjct: 1679 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1738
Query: 214 QEQTVVLQVRPHSDAKEVQVKVMEAAE---ELDAWQSGRELCDGQLRGVQYSTESLMEEM 270
+++ + L+ ++ Q+ E A E A R+ + +L V+ E L+
Sbjct: 1739 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1798
Query: 271 ARADRETR 278
ARA+ E+R
Sbjct: 1799 ARAEEESR 1806
Score = 55.8 bits (133), Expect = 6e-08
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 33/261 (12%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR-LQDLSERERSLL 101
S A A EL L+L GR R + L +AE E+ QR L ER R
Sbjct: 1960 SFEKAAAGKAELELEL------GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2013
Query: 102 RRRSQAAQPLQGEA---REAARERAERVRRRLEEAERHKEDLEQHS-RQLQ--------- 148
R Q + + EA R+AA E ER++ ++EEA R +E EQ S RQLQ
Sbjct: 2014 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2073
Query: 149 EQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEE-------KLQQ 201
Q EE + + Q + T QQ + L L+ E E A EE + Q
Sbjct: 2074 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2133
Query: 202 DALQTAEAWAIFQEQTVVLQVRPHSDA------KEVQVKVMEAAEELDAWQSGRELCDGQ 255
Q EA + Q Q R + A KE + + A+ A ++ D +
Sbjct: 2134 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2193
Query: 256 LRGVQYSTESLMEEMARADRE 276
+ + E + + A+ ++E
Sbjct: 2194 MEKHKKFAEQTLRQKAQVEQE 2214
Score = 52.8 bits (125), Expect = 5e-07
Identities = 55/236 (23%), Positives = 105/236 (44%), Gaps = 25/236 (10%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERER-------SLLRRRSQAAQPLQG--EAR 116
R R +E E R + E+E L +++QD S+R+R S ++ ++AA+ Q +A
Sbjct: 1506 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1565
Query: 117 EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAA 176
E R +AE RRL +AE + Q + + ++ E Q + E+ L
Sbjct: 1566 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1625
Query: 177 QLVTLQNELELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVK 234
+ V + E AE + Q E+ +++A + E W + + + L+++ A++ +
Sbjct: 1626 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1685
Query: 235 VMEAAE-----ELDAWQSG---------RELCDGQLRGVQYSTESLMEEMARADRE 276
EA + E +A + G REL + +L + E ++ A++E
Sbjct: 1686 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1741
Score = 52.4 bits (124), Expect = 6e-07
Identities = 76/273 (27%), Positives = 121/273 (44%), Gaps = 54/273 (19%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL------RRRS 105
Q L + ++ RQ ++E E+L R ++ ES+ Q +L+ R ++ +R
Sbjct: 1503 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1562
Query: 106 QAAQPLQGEAREAAR-------ERAERVRRRLEEAERHKEDLEQHSR--------QLQEQ 150
QA + L+ +A EA R ERA +V+ LE A+R E Q R QL+
Sbjct: 1563 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1622
Query: 151 WEE---LSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKC--ALQ-----EEKLQ 200
+E +QL E ++Q+ E + A + + ELE + K AL+ EE Q
Sbjct: 1623 LQEEHVAVAQLREEAERRAQQQAEAERARE--EAERELERWQLKANEALRLRLQAEEVAQ 1680
Query: 201 QDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG------ 254
Q +L AEA Q++ + R A+E V+ E AE+ + R+L +G
Sbjct: 1681 QKSLAQAEAEK--QKEEAEREARRRGKAEEQAVRQRELAEQ--ELEKQRQLAEGTAQQRL 1736
Query: 255 ----QLRGVQYSTES-------LMEEMARADRE 276
+L ++ TE L EE+AR RE
Sbjct: 1737 AAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1769
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/264 (23%), Positives = 107/264 (40%), Gaps = 29/264 (10%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHL----GSVSTAMAATQELLLQLQKDNRDGRQRKQELEK 74
+ L P+ +PA + G + + T + L Q K + +R +E E+
Sbjct: 1317 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1376
Query: 75 LMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAE 134
L AE ++ E++R L +QA + EA+E + E V RR E A
Sbjct: 1377 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA- 1435
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCAL 194
D +Q R +QE+ + QL E + Q Q AA+ L+ E E+ + L
Sbjct: 1436 ---VDAQQQKRSIQEELQ----QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1488
Query: 195 QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 254
+ + Q+ + E A+ + A+E + + +A EE + + R++ D
Sbjct: 1489 EATERQRGGAE-GELQAL------------RARAEEAEAQKRQAQEEAERLR--RQVQDE 1533
Query: 255 QLRGVQYSTE--SLMEEMARADRE 276
R Q E S ++ A A RE
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAARE 1557
Score = 47.0 bits (110), Expect = 3e-05
Identities = 63/256 (24%), Positives = 121/256 (47%), Gaps = 31/256 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDL-----SERERSLLRRRSQ 106
Q +L QL+ + R+ +E E+ E E+ +++++ S E++ R ++Q
Sbjct: 2100 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2159
Query: 107 AA-QPLQGEAREAARERAERVRRRLE-------EAERHKEDLEQHSRQLQEQWEELSSQL 158
AA + L+ EA + A RA+ + L E E+HK+ EQ RQ + +EL++
Sbjct: 2160 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2219
Query: 159 FYGGEPQSQKSTEQQLAAQLVTLQNE-LELAETKCALQEE----KLQQDALQTAEAWAIF 213
E QK+ L +L L+ E E A + ++EE ++Q + L +A
Sbjct: 2220 LQLEETDHQKNL---LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2276
Query: 214 QEQTVVLQVRPHS------DAKEVQVKVMEAAEELDAWQSG---RELCDGQLRGVQYSTE 264
+ + ++L+ + ++ +A++++ EAA A Q R+L + L + E
Sbjct: 2277 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2336
Query: 265 SLMEEMARADRE-TRL 279
+++E +A +E TRL
Sbjct: 2337 KMLKEKMQAVQEATRL 2352
Score = 46.6 bits (109), Expect = 3e-05
Identities = 65/266 (24%), Positives = 106/266 (39%), Gaps = 56/266 (21%)
Query: 52 QELLLQLQKDNRD-GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR-------- 102
QE +LQ+D +Q +E + R LEAE + ++L+ +E ER LR
Sbjct: 2367 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQ 2423
Query: 103 -RRSQAAQPLQGEARE----------AARER-----------------AERVRRRLEEAE 134
R + AQ + +A E A +E+ AER+R + E E
Sbjct: 2424 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2483
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCAL 194
R KE L+Q ++ LQ + EE+ Q ++QL + LQ L+E L
Sbjct: 2484 REKEKLQQEAKLLQLKSEEM------------QTVQQEQLLQETQALQQSF-LSEKDSLL 2530
Query: 195 QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 254
Q E+ + + A+ +FQ++ Q ++ Q E + + + R
Sbjct: 2531 QRERFIEQ--EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2588
Query: 255 QLRGVQYSTESLME-EMARADRETRL 279
GV+ E L + E R +E L
Sbjct: 2589 AEEGVRRKQEELQQLEQQRRQQEELL 2614
Score = 44.7 bits (104), Expect = 1e-04
Identities = 44/192 (22%), Positives = 88/192 (45%), Gaps = 14/192 (7%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQ 112
E L +L+ + + +++ ++E+ + + + E L++ + R+L+ R Q
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF- 2292
Query: 113 GEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQ 172
+E AE++++ EEA R ++ +R Q E+L+ Q + +K
Sbjct: 2293 ------LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2346
Query: 173 Q----LAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQ---EQTVVLQVRPH 225
Q L A+ LQ + ELA+ + +E +Q A Q AE FQ E Q+
Sbjct: 2347 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2406
Query: 226 SDAKEVQVKVME 237
++A+ ++++V E
Sbjct: 2407 AEAERLKLRVAE 2418
Score = 42.7 bits (99), Expect = 5e-04
Identities = 70/286 (24%), Positives = 118/286 (41%), Gaps = 54/286 (18%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESES---LNQ 88
RL R G V +LL + Q R++ELE+L R L ES L
Sbjct: 1189 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1248
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSR--- 145
LQD RRR + Q + +A RE+ + + LEE ERH E +E+ R
Sbjct: 1249 WLQDA--------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1300
Query: 146 -----------QLQEQWEELSSQLFYGGEPQSQKSTEQQLA---------AQLVTLQNE- 184
QL +L +P+ Q +E + ++L TL ++
Sbjct: 1301 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1360
Query: 185 -------LELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS------DAKEV 231
L E + L E++ ++ + AE A ++Q + + + +AKE+
Sbjct: 1361 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1420
Query: 232 QVKVMEAA---EE--LDAWQSGRELCDGQLRGVQYSTESLMEEMAR 272
Q ++ E EE +DA Q R + + +L+ ++ S+E+ ++ AR
Sbjct: 1421 QQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKAR 1465
Score = 41.6 bits (96), Expect = 0.001
Identities = 41/159 (25%), Positives = 71/159 (44%), Gaps = 11/159 (6%)
Query: 67 QRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERV 126
Q K +LE+L + A++ Q+L++ +R++ + + Q EAR E E V
Sbjct: 2538 QEKAKLEQLFQDEVAKA----QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2593
Query: 127 RRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGE------PQSQKSTEQQLAAQLVT 180
RR+ EE ++ ++ Q L E+ + L QL E S++ T Q+AA T
Sbjct: 2594 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA-TKT 2652
Query: 181 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVV 219
L N + + A E + D L+ + QE ++
Sbjct: 2653 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGIL 2691
Score = 35.4 bits (80), Expect = 0.079
Identities = 42/176 (23%), Positives = 83/176 (47%), Gaps = 23/176 (13%)
Query: 70 QELEKLMRGLEA---ESESLNQRLQDLSERERSL--LRRRSQAAQPLQGEARE---AARE 121
Q E+++R E E++++ L +L + SL LR +++A QP R+ A+E
Sbjct: 1126 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1185
Query: 122 RAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTL 181
ER+++R E + E + QL E+W+ + +Q ++ +QL QL
Sbjct: 1186 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ------TDVRQRELEQLGRQLRYY 1239
Query: 182 QNELELAETKCALQEEKLQQDALQT---AEAWAI----FQEQTVVLQVRPHSDAKE 230
+ + LQ+ + +Q+ +Q A++ A+ QEQ ++ ++ H + E
Sbjct: 1240 RESAD--PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1293
Score = 32.3 bits (72), Expect = 0.67
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q+ + + Q+ + ++++Q++E+ + L A E +R + E +RR+ + Q L
Sbjct: 2548 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG----VRRKQEELQQL 2603
Query: 112 QGEAR---EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
+ + R E E +R+R +L+ E EQH L E +SQ+
Sbjct: 2604 EQQRRQQEELLAEENQRLREQLQLLE------EQHRAALAHSEEVTASQV 2647
Score = 28.9 bits (63), Expect = 7.4
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQE----LEKLMRGLEA----ESESLNQRLQDLSERERS 99
+ A+ E + Q + +G +RKQE LE+ R E E++ L ++LQ L E+ R+
Sbjct: 2575 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2634
Query: 100 LLRRRSQAA--------------QPLQGEAREAARERAERVRRRLEEAERHKE 138
L + L G A EA E + RR A+R +E
Sbjct: 2635 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2687
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 60.1 bits (144), Expect = 3e-09
Identities = 58/250 (23%), Positives = 113/250 (45%), Gaps = 22/250 (8%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQA 107
M +E L Q+ + ++Q LE+ ++ LE E E+ + D S + + + SQ
Sbjct: 1014 MRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQL 1073
Query: 108 AQPLQGEAREA---------ARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
L+ E + +RE+ E++R L + ++DLE L+ Q ++L S++
Sbjct: 1074 EMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRI 1133
Query: 159 FY--GGEPQSQKSTEQQLAAQLVTLQNELELAE-TKCALQ------EEKLQQDALQTAEA 209
+ G S++ Q+ A++ L++ LE E + LQ E K+++ +Q +
Sbjct: 1134 IHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDE 1193
Query: 210 WAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEE 269
+Q L +R K ++ +V EA EE+D +S ++ +L E L +
Sbjct: 1194 HLSLTDQKDQLSLR----LKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQ 1249
Query: 270 MARADRETRL 279
+ ++ RL
Sbjct: 1250 LNSMKKDLRL 1259
Score = 42.4 bits (98), Expect = 6e-04
Identities = 63/246 (25%), Positives = 109/246 (44%), Gaps = 29/246 (11%)
Query: 46 TAMAATQELLLQLQKDNRDGRQRK-----QELEKLMRGLEAESESLNQ------RLQDLS 94
TA L + DN D +RK ++++ L ++ NQ ++DL
Sbjct: 554 TAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLL 613
Query: 95 ERERSLLRRRSQAAQPLQGEAR--EAARERAERVRRRLEE-AERHKEDLEQHS---RQLQ 148
E++ L ++ + LQ E + + +E ER+R LEE +H E +E++S ++L+
Sbjct: 614 EQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLE 673
Query: 149 EQWEELS---SQLFYGGEPQSQKSTE-QQLAAQLVTLQNELELAE-----TKCALQEEKL 199
E EL +LF + Q TE + L QL + +EL+ A+ K AL EE L
Sbjct: 674 ESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELL 733
Query: 200 QQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELD-AWQSGRELCDGQLRG 258
Q A Q + I +E+ L + + ++ + E D +E D +L+
Sbjct: 734 Q--AKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQA 791
Query: 259 VQYSTE 264
++ S E
Sbjct: 792 LRESVE 797
Score = 42.0 bits (97), Expect = 8e-04
Identities = 45/160 (28%), Positives = 74/160 (46%), Gaps = 10/160 (6%)
Query: 58 LQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEARE 117
L + Q + E ++ L+ E+E L R ++L ER + L+R+ + + + +A+E
Sbjct: 806 LASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEEL-ERRVAQLQRQIEDLKGDEAKAKE 864
Query: 118 AARERAERVRRRLEEAERH--KEDLEQHS--RQLQEQWEELSSQLFYGGEPQSQKST--- 170
++ +R+ LEEA H KE+ E S R L+ + E L + Q Q S
Sbjct: 865 TLKKYEGEIRQ-LEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK 923
Query: 171 -EQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEA 209
E + QL L+NE+E EKLQ++ EA
Sbjct: 924 EESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEA 963
Score = 38.5 bits (88), Expect = 0.009
Identities = 53/231 (22%), Positives = 90/231 (38%), Gaps = 19/231 (8%)
Query: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDL---SERERSLLRRRSQAAQPLQGEARE 117
D D +R ++ EK L E Q LQDL E + LLR+R + L+G +E
Sbjct: 712 DELDSAKRSEDREK--GALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKE 769
Query: 118 AARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTE------ 171
+ + + E+ + + L + + + E L+S+ Q Q TE
Sbjct: 770 EVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASR--SNTSEQDQAGTEMRVKLL 827
Query: 172 QQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQ---VRPHSDA 228
Q+ +L ELE + Q E L+ D + E ++ + L+ V +
Sbjct: 828 QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEE 887
Query: 229 KEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRL 279
KE EL+A Q + + + +E L EE + ++ RL
Sbjct: 888 KEAVSARRALENELEAAQGNLSQTTQEQKQL---SEKLKEESEQKEQLRRL 935
Score = 33.5 bits (75), Expect = 0.30
Identities = 35/148 (23%), Positives = 71/148 (47%), Gaps = 14/148 (9%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAES-------ESLNQRLQDLSERER-S 99
++ T + QL + ++ ++K++L +L +E E E L + + D+ E R S
Sbjct: 908 LSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTS 967
Query: 100 LLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLF 159
L ++Q + + RE A E +++ + EAE+ + + ++Q++ + +L
Sbjct: 968 TLELQNQLDEYKEKNRRELA-EMQRQLKEKTLEAEKSR----LTAMKMQDEMRLMEEELR 1022
Query: 160 YGGEPQSQKSTEQQLAAQ-LVTLQNELE 186
Q + T++QL Q L L+ ELE
Sbjct: 1023 DYQRAQDEALTKRQLLEQTLKDLEYELE 1050
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 56.6 bits (135), Expect = 3e-08
Identities = 73/288 (25%), Positives = 120/288 (41%), Gaps = 45/288 (15%)
Query: 4 ATLGLPLPPIVIQPARRSLPP-IVTPASRRLGPRGGRH-LGSVSTAMAATQELLLQ---- 57
A G PLPP+ LPP + P+ RR+ G + S S +E +L+
Sbjct: 289 AMSGQPLPPV--------LPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQ 340
Query: 58 -----------------LQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSL 100
++ N + +R+Q L + R + L + Q+ ERER
Sbjct: 341 QLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQE 400
Query: 101 LRRRSQAAQPLQGEA-REAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLF 159
R+ Q Q E RE R+R E R+ +E E K +LE RQ Q +WE Q
Sbjct: 401 QERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELE---RQRQLEWERNRRQ-- 455
Query: 160 YGGEPQSQKSTEQQ----LAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQE 215
E +Q++ EQ+ L A+ TL+ ELE K E KLQ + +
Sbjct: 456 ---ELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIES 512
Query: 216 QTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYST 263
++R ++ +Q ++ E+ + L +++ + QL+ VQ ++
Sbjct: 513 TNKSRELR-IAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNS 559
Score = 36.6 bits (83), Expect = 0.035
Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 12/90 (13%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSE--RERSLLRRRSQAAQPLQGEAREAARERA 123
R + E+EK R E + N +L++L E ++ L +++S A+ L+ + +E
Sbjct: 583 RDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQE------ 636
Query: 124 ERVRRRLEEAERHKEDLEQHSRQLQEQWEE 153
R++ E E+ KE+ ++ +++ +QW E
Sbjct: 637 ----RKIIELEKQKEEAQRRAQERDKQWLE 662
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 56.6 bits (135), Expect = 3e-08
Identities = 73/288 (25%), Positives = 120/288 (41%), Gaps = 45/288 (15%)
Query: 4 ATLGLPLPPIVIQPARRSLPP-IVTPASRRLGPRGGRH-LGSVSTAMAATQELLLQ---- 57
A G PLPP+ LPP + P+ RR+ G + S S +E +L+
Sbjct: 289 AMSGQPLPPV--------LPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQ 340
Query: 58 -----------------LQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSL 100
++ N + +R+Q L + R + L + Q+ ERER
Sbjct: 341 QLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQE 400
Query: 101 LRRRSQAAQPLQGEA-REAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLF 159
R+ Q Q E RE R+R E R+ +E E K +LE RQ Q +WE Q
Sbjct: 401 QERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELE---RQRQLEWERNRRQ-- 455
Query: 160 YGGEPQSQKSTEQQ----LAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQE 215
E +Q++ EQ+ L A+ TL+ ELE K E KLQ + +
Sbjct: 456 ---ELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIES 512
Query: 216 QTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYST 263
++R ++ +Q ++ E+ + L +++ + QL+ VQ ++
Sbjct: 513 TNKSRELR-IAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNS 559
Score = 36.6 bits (83), Expect = 0.035
Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 12/90 (13%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSE--RERSLLRRRSQAAQPLQGEAREAARERA 123
R + E+EK R E + N +L++L E ++ L +++S A+ L+ + +E
Sbjct: 583 RDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQE------ 636
Query: 124 ERVRRRLEEAERHKEDLEQHSRQLQEQWEE 153
R++ E E+ KE+ ++ +++ +QW E
Sbjct: 637 ----RKIIELEKQKEEAQRRAQERDKQWLE 662
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 55.8 bits (133), Expect = 6e-08
Identities = 62/250 (24%), Positives = 109/250 (43%), Gaps = 18/250 (7%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
QEL+LQ ++ QR ++ + L LE SL +R ++L+ + + + R + P
Sbjct: 1658 QELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP- 1716
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL----FYGGEPQSQ 167
+A R E ++ L + E+ E ++H +LQE ++L QL GE
Sbjct: 1717 ----SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLL 1772
Query: 168 KSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSD 227
S +Q ++V LQ +L+ A + L+E+ LQ + A A ++ LQ +
Sbjct: 1773 LSQREQ---EIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQ----QE 1825
Query: 228 AKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALA 287
++ Q + E+ DA Q E L+ + E+ R + E + G R +
Sbjct: 1826 QQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEG--RRVQ 1883
Query: 288 IRRCVLGALQ 297
VLG L+
Sbjct: 1884 ALEEVLGDLR 1893
Score = 54.3 bits (129), Expect = 2e-07
Identities = 65/257 (25%), Positives = 111/257 (43%), Gaps = 28/257 (10%)
Query: 41 LGSVSTAMAATQELLLQLQKDNRDGRQR----KQELEKLMRGLEAESESLNQR---LQDL 93
L A+A + L LQ++ + + + K++ + L LE +L +R LQD
Sbjct: 1805 LDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDH 1864
Query: 94 SERERSLLR------RRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQL 147
E+ R L RR QA + + G+ R +RE+ + + ++ ++ E +R L
Sbjct: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRAL 1924
Query: 148 QEQWEELSS------QLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQ 201
Q+ W + + Q +SQ S Q+ AA+ + L + ALQ + +Q
Sbjct: 1925 QDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGK--EQ 1982
Query: 202 DALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQY 261
L+ AE + T LQ DA + + +E A + Q G E+ D LR Q
Sbjct: 1983 HLLEQAELSRSLEASTATLQA--SLDACQAHSRQLEEALRI---QEG-EIQDQDLR-YQE 2035
Query: 262 STESLMEEMARADRETR 278
+ L + +A+ D E R
Sbjct: 2036 DVQQLQQALAQRDEELR 2052
Score = 53.5 bits (127), Expect = 3e-07
Identities = 60/251 (23%), Positives = 107/251 (42%), Gaps = 29/251 (11%)
Query: 44 VSTAMAATQELLLQLQKDNR-------DGRQRKQELEKLMRGLEAESESLNQRLQDLSER 96
V+ A+A ++ + +L D R +L L L + LNQ+L L E
Sbjct: 566 VTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEE 625
Query: 97 ERSLLRRRSQAAQPLQG---------EAREAARERAERVRRRLEEAERHKEDLEQHSRQL 147
+S+ R A Q + REA E+ + +L++AE +L+ R +
Sbjct: 626 NQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDI 685
Query: 148 QEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNEL---ELAETKCALQEEKLQQDAL 204
QE+ EE+ +L Q +T+ + Q Q E+ + E + ++E+ + L
Sbjct: 686 QEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRL 745
Query: 205 QTAEAWAIFQEQTVVLQVRPHSDAKE-VQVKVMEAAEELDAWQSGRELCDGQLRGVQYST 263
Q E Q + Q++ S AKE ++ + EA ++ S E+ GQL VQ T
Sbjct: 746 QAVER----DRQDLAEQLQGLSSAKELLESSLFEAQQQ----NSVIEVTKGQLE-VQIQT 796
Query: 264 ESLMEEMARAD 274
+ +E+ + +
Sbjct: 797 VTQAKEVIQGE 807
Score = 51.6 bits (122), Expect = 1e-06
Identities = 57/198 (28%), Positives = 95/198 (47%), Gaps = 32/198 (16%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERS-LLRRRSQAAQPL 111
E LLQ QK+ D Q+LE+L + + ++Q L E+E + +L+ + Q AQ
Sbjct: 932 ETLLQTQKELADA---SQQLERLRQDM---------KVQKLKEQETTGILQTQLQEAQR- 978
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTE 171
E +EAAR+ + + EE+ L Q LQ+Q E+L SQL + SQ+ E
Sbjct: 979 --ELKEAARQHRDDLAALQEESS----SLLQDKMDLQKQVEDLKSQLV--AQDDSQRLVE 1030
Query: 172 QQLAAQL------VTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPH 225
Q++ +L +Q ELE + L + +Q L EA +I Q++ L+
Sbjct: 1031 QEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALR---- 1086
Query: 226 SDAKEVQVKVMEAAEELD 243
D +E Q + E + +++
Sbjct: 1087 QDMQEAQGEQKELSAQME 1104
Score = 47.4 bits (111), Expect = 2e-05
Identities = 58/299 (19%), Positives = 117/299 (39%), Gaps = 56/299 (18%)
Query: 39 RHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRL----QDLS 94
R S++ ++ ++ LL LQ+ + +Q L + M+ + E + L+ ++ Q++
Sbjct: 1052 REKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVK 1111
Query: 95 ERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEEL 154
E+E L + +Q + L EA+ +++R L E L+ R + Q E L
Sbjct: 1112 EKEADFLAQEAQLLEEL-----EASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEAL 1166
Query: 155 SSQLFYGGEPQSQK------STEQQLAAQLVTLQNELE---------------------- 186
+++ G + Q+Q S QQ + + EL
Sbjct: 1167 AAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSL 1226
Query: 187 ---------LAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVR----------PHSD 227
L+ A KL QD +T + + ++Q L+ R H++
Sbjct: 1227 FKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTE 1286
Query: 228 AKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRAL 286
+++Q ++ + EE W+ + + +L + + SL + RA+ + G R L
Sbjct: 1287 LQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGEREL 1345
Score = 46.6 bits (109), Expect = 3e-05
Identities = 59/260 (22%), Positives = 119/260 (45%), Gaps = 47/260 (18%)
Query: 49 AATQELLLQLQKDNRDGRQRKQELEKLMRGLEA---ESESLNQRLQDLSERERSLLRRRS 105
AA + L +++D +D ++ Q L LE+ E++ N ++ + ++ +
Sbjct: 739 AALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798
Query: 106 QAAQPLQGEAR------EAARERAERVR----RRLEEAERH-KEDLEQHS-------RQL 147
QA + +QGE R + R +AE+ R R+L +AE+ K LEQ QL
Sbjct: 799 QAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQL 858
Query: 148 QEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTA 207
+E+WE + + +Q+LA L +L E E E + L+E++ + +A+Q
Sbjct: 859 REKWE------------KERSWHQQELAKALESL--EREKMELEMRLKEQQTEMEAIQAQ 904
Query: 208 EAWAIFQEQTVVLQVRPHSDAKEV---------QVKVMEAAEELDAWQSGRELCDGQLRG 258
Q ++ + Q++ ++ + V Q ++ +A+++L+ + ++ Q
Sbjct: 905 REEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKV---QKLK 961
Query: 259 VQYSTESLMEEMARADRETR 278
Q +T L ++ A RE +
Sbjct: 962 EQETTGILQTQLQEAQRELK 981
Score = 43.1 bits (100), Expect = 4e-04
Identities = 52/240 (21%), Positives = 106/240 (44%), Gaps = 22/240 (9%)
Query: 54 LLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQD----LSERERSLLRRRSQAAQ 109
+L +K+ ++ EL++L LE + + L++++ + LS+RE+ ++ + Q
Sbjct: 1730 ILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQ- 1788
Query: 110 PLQGEAREAARERAERVRRRLEEAER-------HKEDLEQHSRQLQEQWEELSSQL-FYG 161
EARE + + ++ +L+EA+R E L+Q +Q Q Q E + +
Sbjct: 1789 ----EAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQ 1844
Query: 162 GEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQ 221
G + T ++ +L + + E + A++ ++Q + A +EQ L
Sbjct: 1845 GALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALL 1904
Query: 222 VRPHSDAKEVQVKVMEAAEELDAWQSGRELC---DGQLRGVQYSTESL--MEEMARADRE 276
A++ Q +E D+W + + D +L ++ ++S EE ARA E
Sbjct: 1905 ALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAE 1964
Score = 42.4 bits (98), Expect = 6e-04
Identities = 53/234 (22%), Positives = 100/234 (42%), Gaps = 25/234 (10%)
Query: 57 QLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERE--RSLLRRRSQAAQPLQGE 114
Q+Q+ + +K LE L L+ ++ ++ + + + E E RS+L A Q E
Sbjct: 1443 QIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQ----E 1498
Query: 115 AREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQL 174
+ + E++R ++ E + LE +L+++ + + +SQ+ Q L
Sbjct: 1499 REQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMI----------ESQRGQVQDL 1548
Query: 175 AAQLVTLQ---NELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS-DAKE 230
QLVTL+ ELE K Q++ +++ Q T+ L+ R A+
Sbjct: 1549 KKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQS 1608
Query: 231 VQVKVMEA-----AEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRL 279
Q+ +E+ A EL + Q+ +Q E L +++ R D+E L
Sbjct: 1609 SQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELML 1662
Score = 40.4 bits (93), Expect = 0.002
Identities = 60/256 (23%), Positives = 108/256 (42%), Gaps = 31/256 (12%)
Query: 41 LGSVSTAMAATQELLLQLQKD--NRDGRQRK--QELEKLMRGLEAE-----SESLNQRLQ 91
L ++++ QE+ + LQ RD Q++ ELE R LE E + L
Sbjct: 2180 LAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELG 2239
Query: 92 DLSERERSLLRRRSQAAQPL-QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQ 150
E+ L A+P G +++ R+R E +++ + E + L++H+ QL+
Sbjct: 2240 SRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRST 2299
Query: 151 WEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAW 210
E++ + + + E AAQ +L E+ A Q++ Q A+
Sbjct: 2300 LEQVERE-------RRKLKREAMRAAQAGSL--EISKATASSPTQQDGRGQKN-SDAKCV 2349
Query: 211 AIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEM 270
A Q++ V+LQ + + K+ Q + +A Q+ REL G+ +S + +
Sbjct: 2350 AELQKEVVLLQAQLTLERKQKQDYITRSA------QTSRELA-----GLHHSLSHSLLAV 2398
Query: 271 ARADRETRLFGGPRAL 286
A+A T L R L
Sbjct: 2399 AQAPEATVLEAETRRL 2414
Score = 39.7 bits (91), Expect = 0.004
Identities = 52/213 (24%), Positives = 90/213 (42%), Gaps = 26/213 (12%)
Query: 114 EAREAARERAERVRRRLEEAERHKE----DLEQHSRQLQEQWEELSSQLFYGGEPQSQKS 169
+ R+ R++ +++ RL + E K +L+ RQL + EE S + G+ S +S
Sbjct: 1257 QTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSK---WEGKQNSLES 1313
Query: 170 TEQQLAAQLVTLQNELELAETKC--ALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSD 227
+L + +LQ+ L AE + A E +L Q A + A + Q V++ R +
Sbjct: 1314 ELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTA-QVEHLQAAVVEARAQAS 1372
Query: 228 AKEVQVKVMEAA---------------EELDAWQSGRELCDGQLRGVQYSTESLMEEMAR 272
A + + + A E A Q EL Q + +Q + L + +A
Sbjct: 1373 AAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAE 1432
Query: 273 ADRETR-LFGGPRALAIRRCVLGALQVLLTLPL 304
+ E L G + L +R + A LL+L L
Sbjct: 1433 REEEVETLRGQIQELEKQREMQKAALELLSLDL 1465
Score = 35.0 bits (79), Expect = 0.10
Identities = 72/289 (24%), Positives = 119/289 (41%), Gaps = 69/289 (23%)
Query: 48 MAATQEL--LLQLQKDN--RDGRQRKQELEKLMR----------GLEAESESLNQRLQDL 93
+A QE LLQ Q D +G+ +Q L+KL L+ E +SL++ ++L
Sbjct: 409 LAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKE-REL 467
Query: 94 SERERSLLR-------------RRSQAAQPLQGEAREAARE-RAERVRRRLEEAERHKED 139
++ R LR RR LQG++ + +E + E + + E ER +E
Sbjct: 468 LQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEM 527
Query: 140 LEQHSRQLQEQWEEL--------SSQLFYGGEPQSQKSTE--------QQLAAQLVTLQN 183
L + E EL SS L GE Q+ TE +Q A+L + +N
Sbjct: 528 LMGLEAKQSESLSELITLREALESSHL--EGELLRQEQTEVTAALARAEQSIAELSSSEN 585
Query: 184 EL--ELAETKC------------ALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAK 229
L E+A+ + AL + L Q LQ E + Q+V ++ A+
Sbjct: 586 TLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEE-----ENQSVCSRMEAAEQAR 640
Query: 230 E-VQVKVMEAAEELDA-WQSGRELCDGQLRGVQYSTESLMEEMARADRE 276
+QV + EA + +A W+ L + QL+ + + L ++ E
Sbjct: 641 NALQVDLAEAEKRREALWEKNTHL-EAQLQKAEEAGAELQADLRDIQEE 688
Score = 34.3 bits (77), Expect = 0.18
Identities = 53/217 (24%), Positives = 91/217 (41%), Gaps = 36/217 (16%)
Query: 39 RHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLN-------QRLQ 91
+ + + + + A + ++++ ++ + QE ++ + LE E SL QRL
Sbjct: 1010 KQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLL 1069
Query: 92 DLSE------RERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSR 145
L E +E S LR+ Q A QGE +E + A+ R E E+ + L Q ++
Sbjct: 1070 VLQEADSIRQQELSALRQDMQEA---QGEQKELS---AQMELLRQEVKEKEADFLAQEAQ 1123
Query: 146 QLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQ 205
L+E ++ TEQQL A L E + A+ + L+ + Q +AL
Sbjct: 1124 LLEEL--------------EASHITEQQLRASL--WAQEAKAAQLQLRLRSTESQLEAL- 1166
Query: 206 TAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEEL 242
AE Q Q +S ++ V E+ EL
Sbjct: 1167 AAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPEL 1203
Score = 30.8 bits (68), Expect = 1.9
Identities = 54/234 (23%), Positives = 91/234 (38%), Gaps = 23/234 (9%)
Query: 57 QLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAR 116
Q +K +G+Q LE + L SL RL R L R +Q + L A+
Sbjct: 1298 QEEKSKWEGKQ--NSLESELMELHETMASLQSRL-----RRAELQRMEAQGERELLQAAK 1350
Query: 117 EAARERAERVRRRLEEAERH-------KEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKS 169
E + E ++ + EA +EDL L+ + EE+ S+ Q+ +
Sbjct: 1351 ENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESE---RERAQALQE 1407
Query: 170 TEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAK 229
+ AQ LQ L L A +EE+++ Q E + Q L++ D K
Sbjct: 1408 QGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELL-SLDLK 1466
Query: 230 EVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMAR-----ADRETR 278
+ +V E++ + R + + VQ + L + + DRET+
Sbjct: 1467 KRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQ 1520
Score = 30.4 bits (67), Expect = 2.5
Identities = 30/126 (23%), Positives = 57/126 (45%), Gaps = 11/126 (8%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERERSL------LRRRSQAAQPLQGEAREAA 119
R R + L++ + A + Q L + +E RSL L+ A Q + EA
Sbjct: 1960 RARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL 2019
Query: 120 RERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLV 179
R + ++ ++ R++ED++Q + L ++ EEL Q E +KS Q++ ++
Sbjct: 2020 RIQEGEIQ---DQDLRYQEDVQQLQQALAQRDEELRHQ--QEREQLLEKSLAQRVQENMI 2074
Query: 180 TLQNEL 185
+ L
Sbjct: 2075 QEKQNL 2080
>gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens]
Length = 284
Score = 55.5 bits (132), Expect = 7e-08
Identities = 62/245 (25%), Positives = 118/245 (48%), Gaps = 30/245 (12%)
Query: 41 LGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSL 100
L S+ + T++ L + + +D +++ + EK EA+ SLN+R+Q + E
Sbjct: 43 LVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRA 102
Query: 101 LRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY 160
R + A Q L+ EA +AA E ++ A++ +E +E QL+E +
Sbjct: 103 QERLATALQKLE-EAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKE--------AKH 153
Query: 161 GGEPQSQKSTEQQLAAQLVTLQNEL-------ELAETKCALQEEKLQ--QDALQTAEAWA 211
E +K +++A +LV ++++L EL+E KCA EE+L+ + L++ EA A
Sbjct: 154 IAEDADRK--YEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQA 211
Query: 212 IFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMA 271
Q D E ++KV+ +++L ++ E + + ++ S + L E++A
Sbjct: 212 EKYSQ--------KEDRYEEEIKVL--SDKLKEAETRAEFAERSVTKLEKSIDDLEEKVA 261
Query: 272 RADRE 276
A E
Sbjct: 262 HAKEE 266
Score = 35.4 bits (80), Expect = 0.079
Identities = 45/169 (26%), Positives = 71/169 (42%), Gaps = 37/169 (21%)
Query: 124 ERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQL---AAQLVT 180
E R E+AE K+ E S+QL+++ L +L K TE +L + L
Sbjct: 16 ENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKL---------KGTEDELDKYSEALKD 66
Query: 181 LQNELELAETKCA--------------LQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS 226
Q +LELAE K L EE+L + + A A +E +
Sbjct: 67 AQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEE------AEKAA 120
Query: 227 DAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESL---MEEMAR 272
D E +KV+E+ + D + E+ + QL+ ++ E EE+AR
Sbjct: 121 DESERGMKVIESRAQKD--EEKMEIQEIQLKEAKHIAEDADRKYEEVAR 167
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 55.1 bits (131), Expect = 1e-07
Identities = 62/262 (23%), Positives = 116/262 (44%), Gaps = 38/262 (14%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKL------MRGLEAESESLNQRLQDLSERERSLLRRRS 105
+E L K + + +QEL+ L R + + E ++ L E+S+ R +
Sbjct: 1409 EEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYA 1468
Query: 106 QAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGE-- 163
+ + EARE +A + R LEEA KE+ E+ ++QL+ E+L S G+
Sbjct: 1469 EERDRAEAEARE-KETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV 1527
Query: 164 ---PQSQKSTEQQ---LAAQLVTLQNELELAETKCALQEEKLQ------QDALQTAEAWA 211
+S+++ EQQ + QL L++EL+ E E +Q + LQT +
Sbjct: 1528 HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQN 1587
Query: 212 IFQEQTVVLQVR---------------PHSDAKEVQVKVMEAAEELDAWQSGRELCDGQL 256
+++ ++ QVR + K++++ + + +++A R+ QL
Sbjct: 1588 EEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQL 1647
Query: 257 RGVQYSTESLMEEM--ARADRE 276
R +Q + E+ ARA R+
Sbjct: 1648 RKLQAQMKDYQRELEEARASRD 1669
Score = 46.6 bits (109), Expect = 3e-05
Identities = 42/169 (24%), Positives = 76/169 (44%), Gaps = 25/169 (14%)
Query: 52 QELLLQ-LQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQP 110
QE+++ L++ + + +QELEK R L+ E+ L ++ +L + L + ++ +
Sbjct: 1032 QEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEE 1091
Query: 111 LQG-------------EAREAARERAERVRRRLEEAERHK---EDLEQHSRQLQEQWEEL 154
LQG A + RE ++ E+ E K E+ R L E+ E L
Sbjct: 1092 LQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEAL 1151
Query: 155 SSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDA 203
++L + + + A Q + + E E+AE K AL+EE +A
Sbjct: 1152 KTEL--------EDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEA 1192
Score = 46.6 bits (109), Expect = 3e-05
Identities = 61/278 (21%), Positives = 122/278 (43%), Gaps = 39/278 (14%)
Query: 30 SRRLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR 89
+ + G + + S+ + + TQELL Q++ R +K L +R LE E SL ++
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELL---QEETR----QKLNLSSRIRQLEEEKNSLQEQ 1351
Query: 90 LQDLSER----ERSLLRRRSQAAQPLQG------------EAREAARERAERVRRRLEEA 133
++ E E+ +L +SQ A + EA++ + AE + +RLEE
Sbjct: 1352 QEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEK 1411
Query: 134 ERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQ--------NEL 185
+ LE+ +LQ++ ++L+ L + + S +Q+ QL+ + E
Sbjct: 1412 ALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEER 1471
Query: 186 ELAETKCALQEEK---LQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEEL 242
+ AE + +E K L + + EA F+ Q L+ +D +++ + + +
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLR----ADMEDLMSSKDDVGKNV 1527
Query: 243 DAWQSGRELCDGQLRGVQYSTESLMEEM-ARADRETRL 279
+ + + Q+ ++ E L +E+ A D + RL
Sbjct: 1528 HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRL 1565
Score = 46.6 bits (109), Expect = 3e-05
Identities = 46/233 (19%), Positives = 108/233 (46%), Gaps = 22/233 (9%)
Query: 55 LLQLQKDNRDGRQRKQELEKLMRGLEAESE-SLNQRLQDLSERERSLLRRRSQAAQPLQG 113
L +L+ + + K LE M+ ++A+ E L R + E++R L+++ + L+
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 114 EAREAARERAER---------VRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEP 164
E ++ A A + + ++E A + ++++ + R+LQ Q ++ +L
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARAS 1667
Query: 165 ------QSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTV 218
QS++S ++ + + LQ + ELA ++ A + + ++D L + + +
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727
Query: 219 VLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMA 271
+ + + ++ ++ + EEL+ QS EL + + R ++L E+A
Sbjct: 1728 L------DEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Score = 43.5 bits (101), Expect = 3e-04
Identities = 55/271 (20%), Positives = 107/271 (39%), Gaps = 40/271 (14%)
Query: 40 HLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQ---DLSER 96
H + + Q + +LQ+D + + + EK R L E E+L L+ D +
Sbjct: 1105 HKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAA 1164
Query: 97 ERSLLRRRSQAAQPLQGEAREAARER--------------AERVRRRLEEAERHKEDLEQ 142
++ L +R Q L+ E + E + +LE+A+R K +LE+
Sbjct: 1165 QQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK 1224
Query: 143 HSRQLQEQWEELS------SQLFYGGEPQSQKSTEQ----------------QLAAQLVT 180
+ + L+ +EL+ Q+ E + +K Q +LA +
Sbjct: 1225 NKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASK 1284
Query: 181 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAE 240
LQNEL+ T E+K + A A + Q+ +LQ + ++ + E
Sbjct: 1285 LQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL-NLSSRIRQLEE 1343
Query: 241 ELDAWQSGRELCDGQLRGVQYSTESLMEEMA 271
E ++ Q +E + + ++ +L ++A
Sbjct: 1344 EKNSLQEQQEEEEEARKNLEKQVLALQSQLA 1374
Score = 40.0 bits (92), Expect = 0.003
Identities = 55/265 (20%), Positives = 106/265 (40%), Gaps = 47/265 (17%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQA 107
+ A EL + ++ +KQELE+++ LE+ E +R Q L ++ +
Sbjct: 896 LQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDL 955
Query: 108 AQPLQGEAREAARER-------AERVRRRLEE----AERHKEDLEQHSRQLQEQWEELSS 156
+ L E E AR++ AE +++EE E + + ++++ E SS
Sbjct: 956 EEQLDEE--EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSS 1013
Query: 157 QLFYGGEP----------------------QSQKSTEQQLAAQLVTLQNEL-----ELAE 189
QL E + ++ T Q+L L E ++AE
Sbjct: 1014 QLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAE 1073
Query: 190 TKCALQEEKLQ----QDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAW 245
+ + E KLQ ++ LQ A A + + + +E+Q ++ E E+ ++
Sbjct: 1074 LQAQIDELKLQLAKKEEELQGALARG---DDETLHKNNALKVVRELQAQIAELQEDFESE 1130
Query: 246 QSGRELCDGQLRGVQYSTESLMEEM 270
++ R + Q R + E+L E+
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTEL 1155
Score = 39.3 bits (90), Expect = 0.005
Identities = 54/256 (21%), Positives = 107/256 (41%), Gaps = 37/256 (14%)
Query: 56 LQLQKDNRDGRQRKQELEKLM------------RGLEAESESLNQRLQDLSERERSLLRR 103
LQL+K + + +K E E L+ + +E + +L + E+ ++L +
Sbjct: 969 LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKI 1028
Query: 104 RSQAAQPLQGEAREAARERAERVRRRLEEAERHKE----DLEQHSRQLQEQW-------- 151
R++ Q + E ++ E+ R+ LE+A+R + DL+ +LQ Q
Sbjct: 1029 RNK--QEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA 1086
Query: 152 ---EELSSQLFYGGEPQSQKSTE----QQLAAQLVTLQNELELAETKCALQEEKLQQDAL 204
EEL L G + K+ ++L AQ+ LQ + E +E + EK ++D
Sbjct: 1087 KKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFE-SEKASRNKAEKQKRDLS 1145
Query: 205 QTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTE 264
+ EA E T+ + + +V E + L+ E Q++ ++
Sbjct: 1146 EELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE---AQIQDMRQRHA 1202
Query: 265 SLMEEMARADRETRLF 280
+ +EE++ + + F
Sbjct: 1203 TALEELSEQLEQAKRF 1218
>gi|238908495 similar to pleckstrin homology domain protein (5V327)
[Homo sapiens]
Length = 506
Score = 54.7 bits (130), Expect = 1e-07
Identities = 67/246 (27%), Positives = 109/246 (44%), Gaps = 40/246 (16%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQA 107
M T+EL LQ R++++ELE+L + LEAE + + +Q+L + + R
Sbjct: 171 MEETEELCLQ--------REQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELT 222
Query: 108 AQPLQG--EAREAARERAERVRRRLEEAERHK-------EDLEQHSRQLQEQWEE-LSSQ 157
A+ L+G + ++ R E +++ LEE K E+ E H + L Q E+ S
Sbjct: 223 ARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSG 282
Query: 158 LFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEK----LQQDALQTAEAWAIF 213
+ Q ++ +Q L +L+ + E E AL+EE+ Q ALQ +
Sbjct: 283 GLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNS-----L 337
Query: 214 QEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLM-----E 268
QE T Q EV+V+ +D + RE +G LR ++ S + E
Sbjct: 338 QELTAEKQQAERELKAEVKVR-------MDLERRLRE-AEGALRSLEQGLNSKVRNKEKE 389
Query: 269 EMARAD 274
E RAD
Sbjct: 390 ERMRAD 395
>gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]
Length = 1080
Score = 54.7 bits (130), Expect = 1e-07
Identities = 76/301 (25%), Positives = 122/301 (40%), Gaps = 43/301 (14%)
Query: 15 IQPARRSLPPIVTPASRRLGPRGGRHLGSVS--------TAMAATQELLLQLQKDNRDGR 66
+Q R+ L V RLG + R + ++ A T+ L + +K +
Sbjct: 786 LQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQE 845
Query: 67 QRKQ-ELEKLMRGLEAESES------------LNQRLQDLSE-------RERSLLRRRSQ 106
+R Q EL L + LE E ++ L R Q+L E +E L+ R +
Sbjct: 846 RRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLE 905
Query: 107 AAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQS 166
A L E E A E R++R ++ E +LEQ R+LQE+ EL QL GE +
Sbjct: 906 ADMALAKEESEKAAE--SRIKRLRDKYEAELSELEQSERKLQERCSELKGQL---GEAEG 960
Query: 167 QKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAE-AWAIFQEQT-------V 218
+ Q L Q + + + + + L Q Q E A +E+T
Sbjct: 961 ENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELA 1020
Query: 219 VLQVRPHSDAKEVQVKVMEA-AEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRET 277
LQ R + +EV +V A A + +A S R + ++ + E L+E+ R T
Sbjct: 1021 TLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADH-LEELLEQHRRPTPST 1079
Query: 278 R 278
+
Sbjct: 1080 K 1080
Score = 43.9 bits (102), Expect = 2e-04
Identities = 51/206 (24%), Positives = 89/206 (43%), Gaps = 21/206 (10%)
Query: 52 QELLLQLQKDNRD---GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAA 108
+EL+ +K R+ + K+ E +RGLE E + L R + R +SL A
Sbjct: 678 KELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSL-----HEA 732
Query: 109 QPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQK 168
+ LQ + R + +R L +AE +E LE+ L +Q E + Q F Q Q
Sbjct: 733 ELLQSDERAS--------QRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQW 784
Query: 169 STEQQ---LAAQLVTLQNEL--ELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVR 223
+ +QQ L +++ + L + A + L+E + Q + +A A+ E + +
Sbjct: 785 ALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQ 844
Query: 224 PHSDAKEVQVKVMEAAEELDAWQSGR 249
E+ + E AW++GR
Sbjct: 845 ERRHQMELNTLKQQLELERQAWEAGR 870
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 54.3 bits (129), Expect = 2e-07
Identities = 59/246 (23%), Positives = 102/246 (41%), Gaps = 35/246 (14%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGE----------- 114
+Q K++LE+ + L+A+SE + LQ L ++ + L L+G+
Sbjct: 1401 QQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQ 1460
Query: 115 -----AREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL--------FYG 161
A E A+R + + E+ +R K+ L + L++Q EE +
Sbjct: 1461 RRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLE 1520
Query: 162 GEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDA--LQTAEAWAIFQEQTVV 219
E Q S E + A L ++ +L E K QEE+L + A +Q E + E +
Sbjct: 1521 AELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEME 1580
Query: 220 LQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRL 279
+ HS K ME+ +E + R+ C +L+ ++ E E+ + RE R
Sbjct: 1581 RMRQTHS-------KEMESRDE--EVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRE 1631
Query: 280 FGGPRA 285
G A
Sbjct: 1632 LEGKLA 1637
Score = 46.2 bits (108), Expect = 4e-05
Identities = 59/245 (24%), Positives = 108/245 (44%), Gaps = 26/245 (10%)
Query: 47 AMAATQELLLQLQKDN----RDGRQRKQELE----------KLMRGLEAESESLNQRLQD 92
A+ A +L+L K++ R+ Q K +LE K + +E E E L+ ++ D
Sbjct: 1663 ALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDD 1722
Query: 93 LSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWE 152
+++ + +L + S+ LQ E E E E ++HK + Q SR L Q
Sbjct: 1723 IAKAKTALEEQLSR----LQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLA-QIN 1777
Query: 153 ELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDA-LQTAEAWA 211
+L +QL + +Q+L +L LQ+++E E + +Q+A ++ E
Sbjct: 1778 DLQAQL------EEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRL 1831
Query: 212 IFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMA 271
F+ V S KE K+ E ++ A ++ + + +L+ T+ M E+A
Sbjct: 1832 EFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELA 1891
Query: 272 RADRE 276
R + E
Sbjct: 1892 RKEAE 1896
Score = 38.9 bits (89), Expect = 0.007
Identities = 53/273 (19%), Positives = 109/273 (39%), Gaps = 49/273 (17%)
Query: 49 AATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQ-------------RLQDLSE 95
A Q++ Q KD + K++L L ++ + E L++ RL+ E
Sbjct: 1521 AELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEME 1580
Query: 96 RERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELS 155
R R + ++ EAR++ +++ +++ +LEE K+ + + R+L+ + LS
Sbjct: 1581 RMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLS 1640
Query: 156 SQL---FYGGEPQSQKSTEQQLA-------------------AQLVTLQNELELAETKCA 193
Q+ + E + +K ++ A ++ L+N+LE +E CA
Sbjct: 1641 DQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCA 1700
Query: 194 ----------LQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELD 243
++ E L A+A +EQ LQ + E+Q ++ E E+++
Sbjct: 1701 AAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQ----REKNEIQNRLEEDQEDMN 1756
Query: 244 AWQSGRELCDGQLRGVQYSTESLMEEMARADRE 276
+ Q L ++ A++E
Sbjct: 1757 ELMKKHKAAVAQASRDLAQINDLQAQLEEANKE 1789
Score = 37.4 bits (85), Expect = 0.021
Identities = 58/246 (23%), Positives = 106/246 (43%), Gaps = 21/246 (8%)
Query: 44 VSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAE----SESLNQRLQDLSERERS 99
V A + Q+ L Q++ + + KQ++ + R LE + S+ +N+R + +R R
Sbjct: 1597 VEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRK 1656
Query: 100 LLRRRSQA---AQPLQGEAREAARERAE--RVRRRLEEAERHKEDLEQHSRQLQEQWEEL 154
L+R AQ + + +A + E +++ +LEE+E + + ++ + E+L
Sbjct: 1657 DLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDL 1716
Query: 155 SSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQ 214
Q+ + L QL LQ E E + L+E++ + L A+ Q
Sbjct: 1717 HLQI------DDIAKAKTALEEQLSRLQREKN--EIQNRLEEDQEDMNELMKKHKAAVAQ 1768
Query: 215 EQTVVLQVRP-HSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARA 273
+ Q+ + +E + E E+L A QS E + + V S S E R
Sbjct: 1769 ASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSM--VDKSLVSRQEAKIR- 1825
Query: 274 DRETRL 279
+ ETRL
Sbjct: 1826 ELETRL 1831
Score = 36.2 bits (82), Expect = 0.046
Identities = 38/168 (22%), Positives = 75/168 (44%), Gaps = 21/168 (12%)
Query: 56 LQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSER--ERSLLRRRSQAAQP--- 110
L+ Q+D + R + RG A +++QDL+ R ++++ + + P
Sbjct: 1180 LEEQRDEQTSRNLTL-FQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWK 1238
Query: 111 ------------LQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
L E E +++R +LE+AE+ + +L +S +L+ + EL+S+L
Sbjct: 1239 LFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSEL 1298
Query: 159 FYGGEPQSQKSTEQQLAAQLV-TLQNELELAETKCALQEEKLQQDALQ 205
E + +S Q L A+ L+ E E+ E + K Q + ++
Sbjct: 1299 --TDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVME 1344
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 54.3 bits (129), Expect = 2e-07
Identities = 59/246 (23%), Positives = 102/246 (41%), Gaps = 35/246 (14%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGE----------- 114
+Q K++LE+ + L+A+SE + LQ L ++ + L L+G+
Sbjct: 1401 QQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQ 1460
Query: 115 -----AREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL--------FYG 161
A E A+R + + E+ +R K+ L + L++Q EE +
Sbjct: 1461 RRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLE 1520
Query: 162 GEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDA--LQTAEAWAIFQEQTVV 219
E Q S E + A L ++ +L E K QEE+L + A +Q E + E +
Sbjct: 1521 AELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEME 1580
Query: 220 LQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRL 279
+ HS K ME+ +E + R+ C +L+ ++ E E+ + RE R
Sbjct: 1581 RMRQTHS-------KEMESRDE--EVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRE 1631
Query: 280 FGGPRA 285
G A
Sbjct: 1632 LEGKLA 1637
Score = 46.2 bits (108), Expect = 4e-05
Identities = 59/245 (24%), Positives = 108/245 (44%), Gaps = 26/245 (10%)
Query: 47 AMAATQELLLQLQKDN----RDGRQRKQELE----------KLMRGLEAESESLNQRLQD 92
A+ A +L+L K++ R+ Q K +LE K + +E E E L+ ++ D
Sbjct: 1663 ALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDD 1722
Query: 93 LSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWE 152
+++ + +L + S+ LQ E E E E ++HK + Q SR L Q
Sbjct: 1723 IAKAKTALEEQLSR----LQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLA-QIN 1777
Query: 153 ELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDA-LQTAEAWA 211
+L +QL + +Q+L +L LQ+++E E + +Q+A ++ E
Sbjct: 1778 DLQAQL------EEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRL 1831
Query: 212 IFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMA 271
F+ V S KE K+ E ++ A ++ + + +L+ T+ M E+A
Sbjct: 1832 EFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELA 1891
Query: 272 RADRE 276
R + E
Sbjct: 1892 RKEAE 1896
Score = 38.9 bits (89), Expect = 0.007
Identities = 53/273 (19%), Positives = 109/273 (39%), Gaps = 49/273 (17%)
Query: 49 AATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQ-------------RLQDLSE 95
A Q++ Q KD + K++L L ++ + E L++ RL+ E
Sbjct: 1521 AELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEME 1580
Query: 96 RERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELS 155
R R + ++ EAR++ +++ +++ +LEE K+ + + R+L+ + LS
Sbjct: 1581 RMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLS 1640
Query: 156 SQL---FYGGEPQSQKSTEQQLA-------------------AQLVTLQNELELAETKCA 193
Q+ + E + +K ++ A ++ L+N+LE +E CA
Sbjct: 1641 DQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCA 1700
Query: 194 ----------LQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELD 243
++ E L A+A +EQ LQ + E+Q ++ E E+++
Sbjct: 1701 AAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQ----REKNEIQNRLEEDQEDMN 1756
Query: 244 AWQSGRELCDGQLRGVQYSTESLMEEMARADRE 276
+ Q L ++ A++E
Sbjct: 1757 ELMKKHKAAVAQASRDLAQINDLQAQLEEANKE 1789
Score = 37.4 bits (85), Expect = 0.021
Identities = 58/246 (23%), Positives = 106/246 (43%), Gaps = 21/246 (8%)
Query: 44 VSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAE----SESLNQRLQDLSERERS 99
V A + Q+ L Q++ + + KQ++ + R LE + S+ +N+R + +R R
Sbjct: 1597 VEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRK 1656
Query: 100 LLRRRSQA---AQPLQGEAREAARERAE--RVRRRLEEAERHKEDLEQHSRQLQEQWEEL 154
L+R AQ + + +A + E +++ +LEE+E + + ++ + E+L
Sbjct: 1657 DLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDL 1716
Query: 155 SSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQ 214
Q+ + L QL LQ E E + L+E++ + L A+ Q
Sbjct: 1717 HLQI------DDIAKAKTALEEQLSRLQREKN--EIQNRLEEDQEDMNELMKKHKAAVAQ 1768
Query: 215 EQTVVLQVRP-HSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARA 273
+ Q+ + +E + E E+L A QS E + + V S S E R
Sbjct: 1769 ASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSM--VDKSLVSRQEAKIR- 1825
Query: 274 DRETRL 279
+ ETRL
Sbjct: 1826 ELETRL 1831
Score = 36.2 bits (82), Expect = 0.046
Identities = 38/168 (22%), Positives = 75/168 (44%), Gaps = 21/168 (12%)
Query: 56 LQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSER--ERSLLRRRSQAAQP--- 110
L+ Q+D + R + RG A +++QDL+ R ++++ + + P
Sbjct: 1180 LEEQRDEQTSRNLTL-FQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWK 1238
Query: 111 ------------LQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
L E E +++R +LE+AE+ + +L +S +L+ + EL+S+L
Sbjct: 1239 LFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSEL 1298
Query: 159 FYGGEPQSQKSTEQQLAAQLV-TLQNELELAETKCALQEEKLQQDALQ 205
E + +S Q L A+ L+ E E+ E + K Q + ++
Sbjct: 1299 --TDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVME 1344
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 53.9 bits (128), Expect = 2e-07
Identities = 50/247 (20%), Positives = 106/247 (42%), Gaps = 19/247 (7%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQELEKLMRGLEA---ESESLNQRLQDLSERERSLLRRR 104
M +E++ + ++ R + E E+ +R LE E E + ++ + E E+ + +
Sbjct: 318 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 377
Query: 105 SQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEP 164
Q + E RE+ E++R + E + +E + + ++ EQ EE+ Q
Sbjct: 378 RQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQ-EEKMRR 436
Query: 165 QSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRP 224
Q +K EQ+ ++ + ++ E QEEK+ + + E A QEQ ++ R
Sbjct: 437 QEEKIREQE--KKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMR-RQ 493
Query: 225 HSDAKEVQVKVMEAAEEL------------DAWQSGRELCDGQLRGVQYSTESLMEEMAR 272
+E + K+ E E++ W+ ++C+ + + + + +E
Sbjct: 494 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM 553
Query: 273 ADRETRL 279
++E RL
Sbjct: 554 REQEVRL 560
Score = 47.0 bits (110), Expect = 3e-05
Identities = 53/256 (20%), Positives = 120/256 (46%), Gaps = 24/256 (9%)
Query: 40 HLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSER--- 96
HLG +++A +L Q++++ R +Q+ EK+ R E + + +++Q+ E+
Sbjct: 257 HLGKELQSVSA--KLQAQVEENELWNRLNQQQEEKMWRQ-EEKIQEREEKIQEQEEKIRE 313
Query: 97 ERSLLRRRSQAAQPLQGEAR---EAARERAERVR---RRLEEAE--RHKEDLEQHSRQLQ 148
+ +RR+ + + + R E E+ E++R ++ E E R +E+ Q +++
Sbjct: 314 QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR 373
Query: 149 EQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKL--QQDALQT 206
EQ + + + + + E+++ Q +Q + E K QEEK+ Q++ +Q
Sbjct: 374 EQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQ----EEKMGEQEEKMWEQEEEMQE 429
Query: 207 AEAWAIFQEQTVVLQ---VRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYST 263
E QE+ + Q +R + Q ++M+ EE Q G+ +C+ + + +
Sbjct: 430 QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGK-MCEQEAKMQEQEE 488
Query: 264 ESLMEEMARADRETRL 279
+ +E ++E ++
Sbjct: 489 KMRRQEEKIREQEKKI 504
Score = 45.4 bits (106), Expect = 8e-05
Identities = 46/176 (26%), Positives = 82/176 (46%), Gaps = 21/176 (11%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESES------LNQRLQDLSERERSLLRRRSQ 106
+LLL Q+ + +EL+ + L+A+ E LNQ+ ++ R+ ++ R +
Sbjct: 243 KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREE 302
Query: 107 AAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWE------ELSSQLFY 160
Q E E RE+ E++RR+ EE KE E+ RQ + WE EL ++
Sbjct: 303 KIQ----EQEEKIREQEEKMRRQ-EEMMWEKE--EKMRRQEEMMWEKEEKIRELEEKMHE 355
Query: 161 GGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQ 216
+ + Q+ Q+ + + Q + + E K QEEK+++ + E + QEQ
Sbjct: 356 QEKIREQEEKRQE--EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQ 409
Score = 33.5 bits (75), Expect = 0.30
Identities = 16/93 (17%), Positives = 47/93 (50%), Gaps = 5/93 (5%)
Query: 57 QLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAR 116
++Q+ R++++++ + + + + E + ++ + + E+E + + + E
Sbjct: 482 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC-----EQE 536
Query: 117 EAARERAERVRRRLEEAERHKEDLEQHSRQLQE 149
E +E+ E++RR+ E+ + L Q ++QE
Sbjct: 537 EKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
>gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens]
Length = 284
Score = 53.5 bits (127), Expect = 3e-07
Identities = 57/242 (23%), Positives = 114/242 (47%), Gaps = 24/242 (9%)
Query: 41 LGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSL 100
L S+ + T++ L + + +D +++ + EK EA+ SLN+R+Q + E
Sbjct: 43 LVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRA 102
Query: 101 LRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY 160
R + A Q L+ EA +AA E ++ A++ +E +E QL+E +
Sbjct: 103 QERLATALQKLE-EAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKE--------AKH 153
Query: 161 GGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVL 220
E +K +++A +LV ++++LE AE + L E +++Q E +QT+
Sbjct: 154 IAEDADRK--YEEVARKLVIIESDLERAEERAELSEGQVRQ-----LEEQLRIMDQTLKA 206
Query: 221 ------QVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARAD 274
+ D E ++KV+ +++L ++ E + + ++ S + L E++A A
Sbjct: 207 LMAAEDKYSQKEDRYEEEIKVL--SDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAK 264
Query: 275 RE 276
E
Sbjct: 265 EE 266
Score = 35.4 bits (80), Expect = 0.079
Identities = 45/169 (26%), Positives = 71/169 (42%), Gaps = 37/169 (21%)
Query: 124 ERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQL---AAQLVT 180
E R E+AE K+ E S+QL+++ L +L K TE +L + L
Sbjct: 16 ENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKL---------KGTEDELDKYSEALKD 66
Query: 181 LQNELELAETKCA--------------LQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS 226
Q +LELAE K L EE+L + + A A +E +
Sbjct: 67 AQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEE------AEKAA 120
Query: 227 DAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESL---MEEMAR 272
D E +KV+E+ + D + E+ + QL+ ++ E EE+AR
Sbjct: 121 DESERGMKVIESRAQKD--EEKMEIQEIQLKEAKHIAEDADRKYEEVAR 167
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 53.5 bits (127), Expect = 3e-07
Identities = 51/212 (24%), Positives = 96/212 (45%), Gaps = 22/212 (10%)
Query: 49 AATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAA 108
AA +E LL+LQ+ + ++ QELE L++ + ++E L LQ+ ER RS R QA
Sbjct: 341 AAKEEELLRLQQLQEEKERKLQELE-LLQEAQRQAERL---LQEEEERRRSQHRELQQA- 395
Query: 109 QPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQK 168
L+G+ REA + RA ++ +E E Q ++L+E + L L
Sbjct: 396 --LEGQLREAEQARAS-MQAEMELKEEEAARQRQRIKELEEMQQRLQEAL---------- 442
Query: 169 STEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDA 228
QL + + + +A+T+ +EE+ + +Q E + E+ + +
Sbjct: 443 ----QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEM 498
Query: 229 KEVQVKVMEAAEELDAWQSGRELCDGQLRGVQ 260
+ + +A ++L+ + R+ D + Q
Sbjct: 499 AQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQ 530
Score = 50.4 bits (119), Expect = 2e-06
Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 35/238 (14%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLL- 101
++ A+ E L KD + R+ ++E + R + E Q+LQ+ ER+ L
Sbjct: 306 AIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELE 365
Query: 102 ------------------RRRSQ---AAQPLQGEAREAARERAE---RVRRRLEEAERHK 137
RRRSQ Q L+G+ REA + RA + + EEA R +
Sbjct: 366 LLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQR 425
Query: 138 EDLEQHSRQLQEQWEELSSQLFYGGEPQSQK-------STEQQLAAQLVTLQNELELAET 190
+ +++ Q E L ++ + +S + E++ QL+ L+ E E
Sbjct: 426 QRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIE 485
Query: 191 KCALQEEKLQQDALQTAEAWAIFQEQTVVL---QVRPHSDAKEVQVKVMEAAEELDAW 245
+ ++E+LQQ+ Q + + Q+Q + + R D + Q K+ +A+ + W
Sbjct: 486 RAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHW 543
Score = 47.0 bits (110), Expect = 3e-05
Identities = 60/242 (24%), Positives = 107/242 (44%), Gaps = 39/242 (16%)
Query: 62 NRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARE 121
+RDG++ ++ R E + QR Q+ + + +R +++ L + ++ RE
Sbjct: 273 DRDGKRCMFCVKTANRTYEMSASDTRQR-QEWTAAIQMAIRLQAEGKTSLHKDLKQKRRE 331
Query: 122 RAERVRRR--------------LEEAERHKEDLE-------QHSRQLQEQWEELSSQLFY 160
+ E+ RR EE ER ++LE Q R LQE+ E SQ
Sbjct: 332 QREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQ--- 388
Query: 161 GGEPQSQKSTEQQL--AAQL-VTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQT 217
+ Q++ E QL A Q ++Q E+EL E + A Q +++++ E ++
Sbjct: 389 --HRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKE-----LEEMQQRLQEA 441
Query: 218 VVLQVRPHSDAKEV---QVKVMEAAEE-LDAWQSGRELCDGQLRGVQYSTESLMEEMARA 273
+ L+V+ D + V Q +++E EE L +E + + Q E L +EMA+
Sbjct: 442 LQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQ 501
Query: 274 DR 275
R
Sbjct: 502 SR 503
>gi|47519616 tropomyosin 2 (beta) isoform 2 [Homo sapiens]
Length = 284
Score = 53.5 bits (127), Expect = 3e-07
Identities = 53/231 (22%), Positives = 110/231 (47%), Gaps = 16/231 (6%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQA 107
+ T++ + + + ++ +++ ++ EK EA+ SLN+R+Q + E R + A
Sbjct: 50 LKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATA 109
Query: 108 AQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQ 167
Q L+ EA +AA E ++ A + +E +E QL+E + E +
Sbjct: 110 LQKLE-EAEKAADESERGMKVIENRAMKDEEKMELQEMQLKE--------AKHIAEDSDR 160
Query: 168 KSTEQQLAAQLVTLQNELELAETKCALQEEKLQQ--DALQTAEAWAIFQEQTVVLQVRPH 225
K +++A +LV L+ ELE +E + + E + +Q + L+T + A+ +
Sbjct: 161 K--YEEVARKLVILEGELERSEERAEVAESRARQLEEELRTMDQ-ALKSLMASEEEYSTK 217
Query: 226 SDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRE 276
D E ++K++E E+L ++ E + + ++ + + L E +A A E
Sbjct: 218 EDKYEEEIKLLE--EKLKEAETRAEFAERSVAKLEKTIDDLEETLASAKEE 266
Score = 35.8 bits (81), Expect = 0.060
Identities = 29/106 (27%), Positives = 49/106 (46%), Gaps = 2/106 (1%)
Query: 55 LLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDL--SERERSLLRRRSQAAQPLQ 112
L+ L+ + +R + E R LE E +++Q L+ L SE E S + + L
Sbjct: 169 LVILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEYSTKEDKYEEEIKLL 228
Query: 113 GEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
E + A RAE R + + E+ +DLE+ +E+ E+ L
Sbjct: 229 EEKLKEAETRAEFAERSVAKLEKTIDDLEETLASAKEENVEIHQTL 274
Score = 33.5 bits (75), Expect = 0.30
Identities = 32/131 (24%), Positives = 61/131 (46%), Gaps = 20/131 (15%)
Query: 129 RLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQ----------- 177
R E+AE K+ E +QL+E+ + L +L G E + +K +E AQ
Sbjct: 21 RAEQAEADKKQAEDRCKQLEEEQQALQKKL-KGTEDEVEKYSESVKEAQEKLEQAEKKAT 79
Query: 178 -----LVTLQNELELAETKCALQEEKLQQ--DALQTAEAWAIFQEQTV-VLQVRPHSDAK 229
+ +L ++L E + +E+L L+ AE A E+ + V++ R D +
Sbjct: 80 DAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE 139
Query: 230 EVQVKVMEAAE 240
+++++ M+ E
Sbjct: 140 KMELQEMQLKE 150
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 53.5 bits (127), Expect = 3e-07
Identities = 58/256 (22%), Positives = 117/256 (45%), Gaps = 40/256 (15%)
Query: 50 ATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQ 109
A+Q L Q+++ + +Q++Q+L+++ EA + Q+L +E + LR R A +
Sbjct: 545 ASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALK 604
Query: 110 PLQGEARE-------------AARERAERVRRRLEEAERHKEDL--------------EQ 142
L+ +E A E + + + +A+R K +L Q
Sbjct: 605 QLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQ 664
Query: 143 HSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQ-LVTLQNELELAETKCALQEEKLQQ 201
+ Q Q EL QL + QK+TE++ AQ LQ +L+ + + + L++
Sbjct: 665 EQHEAQAQVAELELQL----RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE 720
Query: 202 DALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGV-- 259
+ + A+ A+ ++Q + +++ + + Q K +EL+ ++GR+ + +L+ +
Sbjct: 721 EKRRAAD--ALEEQQRCISELKAETRSLVEQHK--RERKELEEERAGRKGLEARLQQLGE 776
Query: 260 --QYSTESLMEEMARA 273
Q TE L E+A A
Sbjct: 777 AHQAETEVLRRELAEA 792
Score = 52.8 bits (125), Expect = 5e-07
Identities = 56/223 (25%), Positives = 94/223 (42%), Gaps = 25/223 (11%)
Query: 57 QLQKDNRDGRQRKQELE-------KLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQ 109
+L+K D R + ELE KL+ +A+ + QR+ +R L QAA
Sbjct: 218 RLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRI------DRLALLNEKQAAS 271
Query: 110 PLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKS 169
PL+ + E R++ E + RL E + +DL+ Q+ + +LS E
Sbjct: 272 PLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSE------ENGDLSF 325
Query: 170 TEQQLAAQLVTLQNEL-ELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDA 228
++ A+ L LQ+ L EL E +E L++ A E A Q++ +
Sbjct: 326 KLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCL-----EEKN 380
Query: 229 KEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMA 271
+ +Q K+ + E L Q G++ G E+L +E A
Sbjct: 381 EILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAA 423
Score = 50.8 bits (120), Expect = 2e-06
Identities = 62/242 (25%), Positives = 108/242 (44%), Gaps = 41/242 (16%)
Query: 47 AMAATQELLLQLQKDNRDGRQRK---QELEKLMRGLEAESESLNQRLQDLSERERSLLRR 103
A A EL LQL+ + + +++ QE ++L L+A ESL L E +R
Sbjct: 669 AQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR----- 723
Query: 104 RSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEE------LSSQ 157
+AA L+ + R + +AE + +EQH R+ +E EE L ++
Sbjct: 724 --RAADALEEQQRCISELKAET-----------RSLVEQHKRERKELEEERAGRKGLEAR 770
Query: 158 LFYGGEPQS------QKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWA 211
L GE ++ + +AAQ T ++E E + A E+ + + A+ A
Sbjct: 771 LQQLGEAHQAETEVLRRELAEAMAAQ-HTAESECEQLVKEVAAWRERYEDSQQEEAQYGA 829
Query: 212 IFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMA 271
+FQEQ + L+ + ++ + ++ EA E++ +S EL Q+ Q L +A
Sbjct: 830 MFQEQLMTLK----EECEKARQELQEAKEKVAGIESHSEL---QISRQQNELAELHANLA 882
Query: 272 RA 273
RA
Sbjct: 883 RA 884
Score = 45.4 bits (106), Expect = 8e-05
Identities = 41/164 (25%), Positives = 87/164 (53%), Gaps = 5/164 (3%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQ-- 109
+EL +L ++ + ++Q+L K ++ ES+ QRLQ ++ L ++ QAA+
Sbjct: 1552 EELSKKLADSDQASKVQQQKL-KAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHY 1610
Query: 110 PLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGG-EPQSQK 168
LQ E + + ++ + L+E R E L++ +++L+ + E L +L G + + +
Sbjct: 1611 KLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAE 1670
Query: 169 STEQQLAAQLVTLQNELELAETKCA-LQEEKLQQDALQTAEAWA 211
T + L AQ+ +L+ ++ A+ + L + ++ DAL++ E A
Sbjct: 1671 QTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQA 1714
Score = 42.4 bits (98), Expect = 6e-04
Identities = 55/202 (27%), Positives = 85/202 (42%), Gaps = 39/202 (19%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQ------------------RKQELE 73
RL GR ++ AA EL ++LQ + R + QEL
Sbjct: 1008 RLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELA 1067
Query: 74 KLMRGLEA----ESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRR 129
KL RGLEA E E L Q ++ L E+ L ++ + G EAA R E +
Sbjct: 1068 KL-RGLEAAQIKELEELRQTVKQLKEQ----LAKKEKEHASGSGAQSEAAG-RTEPTGPK 1121
Query: 130 LEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNEL---- 185
LE LEQ ++ QEQ + L L ++++++ + + L TLQ +L
Sbjct: 1122 LEALRAEVSKLEQQCQKQQEQADSLERSL------EAERASRAERDSALETLQGQLEEKA 1175
Query: 186 -ELAETKCALQEEKLQQDALQT 206
EL ++ AL + + A +T
Sbjct: 1176 QELGHSQSALASAQRELAAFRT 1197
Score = 42.4 bits (98), Expect = 6e-04
Identities = 67/268 (25%), Positives = 107/268 (39%), Gaps = 56/268 (20%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARE---- 121
R +LE+ + + +++SL + L E ER+ R A + LQG+ E A+E
Sbjct: 1126 RAEVSKLEQQCQKQQEQADSLERSL----EAERASRAERDSALETLQGQLEEKAQELGHS 1181
Query: 122 ----------------------RAE-----RVRRRLEEAERH-------KEDLEQHSRQL 147
+AE +V R +EAER +E++ +RQ+
Sbjct: 1182 QSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQV 1241
Query: 148 QEQWEELS--SQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQ 205
E+ E +L +SQK E+ Q T N AE AL+EE Q +
Sbjct: 1242 LEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREE--VQSLRE 1299
Query: 206 TAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQS---GRELCDGQLRGVQYS 262
AE + E L+ S A+ + E +EL AWQ +E L+ S
Sbjct: 1300 EAEKQRVASEN---LRQELTSQAERAE----ELGQELKAWQEKFFQKEQALSTLQLEHTS 1352
Query: 263 TESLMEEMARADRETRLFGGPRALAIRR 290
T++L+ E+ A + +A A +R
Sbjct: 1353 TQALVSELLPAKHLCQQLQAEQAAAEKR 1380
Score = 40.8 bits (94), Expect = 0.002
Identities = 36/145 (24%), Positives = 71/145 (48%), Gaps = 11/145 (7%)
Query: 57 QLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQG--E 114
QL ++N D + +E ++ L+ ++LN+ ++ S+ + L +++Q + L +
Sbjct: 315 QLSEENGDLSFKLREFASHLQQLQ---DALNELTEEHSKATQEWLEKQAQLEKELSAALQ 371
Query: 115 AREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQL 174
++ E+ E ++ +L + E H L+ + Q E+ E L L + ++ K L
Sbjct: 372 DKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQ--EKGEVLGDVL----QLETLKQEAATL 425
Query: 175 AAQLVTLQNELELAETKCALQEEKL 199
AA LQ +E+ ET+ QE KL
Sbjct: 426 AANNTQLQARVEMLETERGQQEAKL 450
Score = 40.8 bits (94), Expect = 0.002
Identities = 43/164 (26%), Positives = 68/164 (41%), Gaps = 24/164 (14%)
Query: 36 RGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSE 95
+GG A EL QL + + K ++EK +A+ Q+ Q+L E
Sbjct: 1578 QGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAK----KQQNQELQE 1633
Query: 96 RERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELS 155
+ RSL + LQ E +E R AER+ L++A ++ EQ R L Q L
Sbjct: 1634 QLRSL--------EQLQKENKE-LRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLE 1684
Query: 156 SQLFYGGE-----------PQSQKSTEQQLAAQLVTLQNELELA 188
+Q+ + + + KS E Q QL + L+L+
Sbjct: 1685 AQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLS 1728
Score = 38.5 bits (88), Expect = 0.009
Identities = 51/257 (19%), Positives = 112/257 (43%), Gaps = 11/257 (4%)
Query: 29 ASRRLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQ 88
AS+ G R + S+++ + + Q ++ +Q+ +E + + + E +Q
Sbjct: 488 ASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQ 547
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHS---R 145
L+ E+ S L+++ Q + + E +EA R+ + ++ AE + L + +
Sbjct: 548 GLRHQVEQLSSSLKQKEQQLKEV-AEKQEATRQ--DHAQQLATAAEEREASLRERDAALK 604
Query: 146 QLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQ 205
QL+ +E +++L + Q Q + E + +AQ Q + E AE ++E + + +
Sbjct: 605 QLEALEKEKAAKLEI-LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETAR 663
Query: 206 TAEAWAIFQEQTVVLQVRPH----SDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQY 261
+ A Q + LQ+R ++ + V + + E+L A + ++ G L +
Sbjct: 664 QEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR 723
Query: 262 STESLMEEMARADRETR 278
+EE R E +
Sbjct: 724 RAADALEEQQRCISELK 740
Score = 37.0 bits (84), Expect = 0.027
Identities = 57/253 (22%), Positives = 113/253 (44%), Gaps = 43/253 (16%)
Query: 41 LGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSL 100
L ++ MAAT + + +L+ R +++ E R L E R + E ++
Sbjct: 902 LSTLQEKMAATSKEVARLETLVRKAGEQQ---ETASRELVKEPARAGDRQPEWLEEQQGR 958
Query: 101 LRRRSQAA-QPLQGEAREAARERAERVRRRLEEAE-RHKEDLEQHSRQLQEQWEELSSQL 158
+QAA Q ++ EA + E ER+R L E++ + +E+ Q R++ +E
Sbjct: 959 QFCSTQAALQAMEREAEQMGNE-LERLRAALMESQGQQQEERGQQEREVARLTQE----- 1012
Query: 159 FYGGEPQSQKSTEQQLAAQL-VTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQT 217
G Q+ + E+ A+L + LQN AL E++++ LQ A A A+ +++
Sbjct: 1013 --RGRAQADLALEKAARAELEMRLQN---------ALNEQRVEFATLQEALAHALTEKE- 1060
Query: 218 VVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRET 277
D + +++ +EAA+ +L ++ + + L E++A+ ++E
Sbjct: 1061 -------GKDQELAKLRGLEAAQ------------IKELEELRQTVKQLKEQLAKKEKEH 1101
Query: 278 RLFGGPRALAIRR 290
G ++ A R
Sbjct: 1102 ASGSGAQSEAAGR 1114
Score = 36.2 bits (82), Expect = 0.046
Identities = 63/319 (19%), Positives = 124/319 (38%), Gaps = 81/319 (25%)
Query: 39 RHLGSVSTAMAATQELLLQLQKDNRD--------------GRQRKQELEKLMRGLEAESE 84
+ LG +A+A+ Q L + +D GRQ + L+ LE E
Sbjct: 1176 QELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVS 1235
Query: 85 SLNQRLQDLSERERSLLR------RRSQAAQP----LQGEAREAARERAERVRRRLEEAE 134
LN+++ + + L R +SQ + LQ E + AER EE +
Sbjct: 1236 ILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQ 1295
Query: 135 RHKEDLEQHSRQLQEQWEELSSQL----------------FYGGEP-----QSQKSTEQQ 173
+E+ E+ + +EL+SQ F+ E Q + ++ Q
Sbjct: 1296 SLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQA 1355
Query: 174 LAAQLVTLQNELELAETKCALQEEKLQQDALQTAEA----------------------WA 211
L ++L+ ++ + + + A E++ +++ Q+ +A
Sbjct: 1356 LVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQK 1415
Query: 212 IFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQS---------GRELCDGQLRGVQYS 262
+ +++ Q+R + Q+ +++ A L A ++ GR+ + +L +
Sbjct: 1416 VAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVEL---DQA 1472
Query: 263 TESLMEEMA--RADRETRL 279
E ++E+A RAD ETRL
Sbjct: 1473 REKYVQELAAVRADAETRL 1491
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 52.8 bits (125), Expect = 5e-07
Identities = 48/191 (25%), Positives = 89/191 (46%), Gaps = 13/191 (6%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQR-KQELEKLMR 77
RR P + + R +H + AM ++ ++ + ++ +R K+EL + ++
Sbjct: 293 RRRKPDTIEVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLK 352
Query: 78 GLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARER--AERVRRRLEEAER 135
+E +++ Q L++ + R L + R +A Q EA + A+ER AE + L +A R
Sbjct: 353 QIEEQTKKAQQELEEQTRRALELEQERKRA----QSEAEKLAKERQEAEEAKEALLQASR 408
Query: 136 HKEDLEQHSRQLQEQWEELS---SQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKC 192
D ++ QL + EL+ SQL + + ++ E Q AQ+V E AE K
Sbjct: 409 ---DQKKTQEQLALEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKT 465
Query: 193 ALQEEKLQQDA 203
A+ + + A
Sbjct: 466 AMSTPHVAEPA 476
Score = 40.0 bits (92), Expect = 0.003
Identities = 38/203 (18%), Positives = 86/203 (42%), Gaps = 24/203 (11%)
Query: 86 LNQRLQDLSERERSLLRRRSQA----AQPLQGEAREAARERA------ERVRRRLEEAER 135
+N+R+ L L RR + Q ++ +ARE ++ E +++ E AE+
Sbjct: 276 INKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQMERAMLENEKKKREMAEK 335
Query: 136 HKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQ 195
KE +E+ +L E+ +++ Q ++Q+ E+Q L ELE + +
Sbjct: 336 EKEKIEREKEELMERLKQIEEQT-----KKAQQELEEQTRRAL-----ELEQERKRAQSE 385
Query: 196 EEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQ 255
EKL ++ + EA +E + +++ +++ E + + R+ + +
Sbjct: 386 AEKLAKERQEAEEA----KEALLQASRDQKKTQEQLALEMAELTARISQLEMARQKKESE 441
Query: 256 LRGVQYSTESLMEEMARADRETR 278
Q + + E++ + E +
Sbjct: 442 AVEWQQKAQMVQEDLEKTRAELK 464
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 52.8 bits (125), Expect = 5e-07
Identities = 37/124 (29%), Positives = 70/124 (56%), Gaps = 7/124 (5%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAER 125
+++++E E+L + EA+ + QR Q+ E+ER RR Q + + E RE R+ AE+
Sbjct: 666 KKKEEEQERLRKAAEAKRLA-EQREQERREQERREQERREQERR--EQERREQERQLAEQ 722
Query: 126 VRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNEL 185
RRR +E + + +L++ + L+ Q E+L +L E + +K +Q+LA + + + E
Sbjct: 723 ERRREQERLQAERELQEREKALRLQKEQLQREL----EEKKKKEEQQRLAERQLQEEQEK 778
Query: 186 ELAE 189
+ E
Sbjct: 779 KAKE 782
Score = 48.9 bits (115), Expect = 7e-06
Identities = 43/144 (29%), Positives = 75/144 (52%), Gaps = 8/144 (5%)
Query: 64 DGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERA 123
+ R++++E + +R L+ E E +R Q+L ++++ + R + A + A + +ER
Sbjct: 636 EARRKQEEEARRLRWLQQEEEE--RRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR 693
Query: 124 ERVRRRLE--EAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTL 181
E+ RR E E ER +++ + RQL EQ E Q E + Q+ E+ L Q L
Sbjct: 694 EQERREQERREQERREQERREQERQLAEQ-ERRREQERLQAERELQE-REKALRLQKEQL 751
Query: 182 QNELELAETKCALQEEKLQQDALQ 205
Q ELE E K ++++L + LQ
Sbjct: 752 QRELE--EKKKKEEQQRLAERQLQ 773
Score = 48.5 bits (114), Expect = 9e-06
Identities = 37/125 (29%), Positives = 62/125 (49%), Gaps = 7/125 (5%)
Query: 39 RHLGSVSTAMAATQELLLQLQKDNRDGRQRKQEL------EKLMRGLEAESESLNQRLQD 92
RH + QE L + + R QR+QE E+ R E + ++ +
Sbjct: 659 RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQ 718
Query: 93 LSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWE 152
L+E+ER + R QA + LQ E +A R + E+++R LEE ++ +E RQLQE+ E
Sbjct: 719 LAEQERRREQERLQAERELQ-EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQE 777
Query: 153 ELSSQ 157
+ + +
Sbjct: 778 KKAKE 782
Score = 47.0 bits (110), Expect = 3e-05
Identities = 47/199 (23%), Positives = 93/199 (46%), Gaps = 18/199 (9%)
Query: 84 ESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQH 143
E QRL++L +E + RR + + + E +R ER+R+ L+ ER ++ E+
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
Query: 144 SRQLQEQWEELSSQLFYGGEPQSQKSTEQQLA---AQLVTLQNELELAETKCALQEEKLQ 200
+Q+++++ ++ + +++K+ E++LA A+ ++E E + +EE +
Sbjct: 596 KKQIEQKFAQI--------DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 647
Query: 201 QDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQ 260
LQ E QE +LQ + +E Q ++ +AAE + + Q R Q
Sbjct: 648 LRWLQQEEEERRHQE---LLQKK----KEEEQERLRKAAEAKRLAEQREQERREQERREQ 700
Query: 261 YSTESLMEEMARADRETRL 279
E E R ++E +L
Sbjct: 701 ERREQERREQERREQERQL 719
Score = 44.3 bits (103), Expect = 2e-04
Identities = 36/126 (28%), Positives = 65/126 (51%), Gaps = 3/126 (2%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
QELL + +++ ++ ++ E ++L E E +R Q+ E+ER RR Q Q
Sbjct: 661 QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720
Query: 112 QGEAR-EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKST 170
+ E R E R +AER + E+A R ++ EQ R+L+E+ ++ Q + Q ++
Sbjct: 721 EQERRREQERLQAERELQEREKALRLQK--EQLQRELEEKKKKEEQQRLAERQLQEEQEK 778
Query: 171 EQQLAA 176
+ + AA
Sbjct: 779 KAKEAA 784
Score = 40.8 bits (94), Expect = 0.002
Identities = 46/196 (23%), Positives = 89/196 (45%), Gaps = 21/196 (10%)
Query: 56 LQLQKDNRDGRQRK--QELEKLMRGLEAESESLNQRLQDLSERERSL---------LRRR 104
L+ K R+ R RK Q E++ + E + + + Q+ + E+ +++
Sbjct: 567 LEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKK 626
Query: 105 SQAAQPLQGEAREAARERAERVR--RRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGG 162
+ A + + EAR E A R+R ++ EE RH+E L++ + QE+ + +++
Sbjct: 627 AAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK-AAEAKRLA 685
Query: 163 EPQSQKSTEQQLAAQLVTLQNELEL----AETKCALQEEKLQQDALQTAEAWAIFQEQTV 218
E + Q+ EQ+ Q Q E E + A QE + +Q+ LQ QE+
Sbjct: 686 EQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERE---LQEREK 742
Query: 219 VLQVRPHSDAKEVQVK 234
L+++ +E++ K
Sbjct: 743 ALRLQKEQLQRELEEK 758
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 52.8 bits (125), Expect = 5e-07
Identities = 37/124 (29%), Positives = 70/124 (56%), Gaps = 7/124 (5%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAER 125
+++++E E+L + EA+ + QR Q+ E+ER RR Q + + E RE R+ AE+
Sbjct: 662 KKKEEEQERLRKAAEAKRLA-EQREQERREQERREQERREQERR--EQERREQERQLAEQ 718
Query: 126 VRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNEL 185
RRR +E + + +L++ + L+ Q E+L +L E + +K +Q+LA + + + E
Sbjct: 719 ERRREQERLQAERELQEREKALRLQKEQLQREL----EEKKKKEEQQRLAERQLQEEQEK 774
Query: 186 ELAE 189
+ E
Sbjct: 775 KAKE 778
Score = 50.1 bits (118), Expect = 3e-06
Identities = 63/273 (23%), Positives = 119/273 (43%), Gaps = 36/273 (13%)
Query: 15 IQPARRSLPPIVTPASRRLGP-RGGRHLGS----VSTAMAATQELLLQLQKDNRDGRQRK 69
+QP R P PAS+ + P R H + T +A + ++ K N R
Sbjct: 471 LQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDP 530
Query: 70 QELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRR 129
+E E+ QRL++L +E + RR + + + E +R ER+R+
Sbjct: 531 KEKER-------------QRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKV 577
Query: 130 LEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLA---AQLVTLQNELE 186
L+ ER ++ E+ +Q+++++ ++ + +++K+ E++LA A+ ++E
Sbjct: 578 LQARERVEQMKEEKKKQIEQKFAQI--------DEKTEKAKEERLAEEKAKKKAAAKKME 629
Query: 187 LAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQ 246
E + +EE + LQ E QE +LQ + +E Q ++ +AAE +
Sbjct: 630 EVEARRKQEEEARRLRWLQQEEEERRHQE---LLQKK----KEEEQERLRKAAEAKRLAE 682
Query: 247 SGRELCDGQLRGVQYSTESLMEEMARADRETRL 279
+ Q R Q E E R ++E +L
Sbjct: 683 QREQERREQERREQERREQERREQERREQERQL 715
Score = 48.5 bits (114), Expect = 9e-06
Identities = 37/125 (29%), Positives = 62/125 (49%), Gaps = 7/125 (5%)
Query: 39 RHLGSVSTAMAATQELLLQLQKDNRDGRQRKQEL------EKLMRGLEAESESLNQRLQD 92
RH + QE L + + R QR+QE E+ R E + ++ +
Sbjct: 655 RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQ 714
Query: 93 LSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWE 152
L+E+ER + R QA + LQ E +A R + E+++R LEE ++ +E RQLQE+ E
Sbjct: 715 LAEQERRREQERLQAERELQ-EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQE 773
Query: 153 ELSSQ 157
+ + +
Sbjct: 774 KKAKE 778
Score = 44.3 bits (103), Expect = 2e-04
Identities = 36/126 (28%), Positives = 65/126 (51%), Gaps = 3/126 (2%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
QELL + +++ ++ ++ E ++L E E +R Q+ E+ER RR Q Q
Sbjct: 657 QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 716
Query: 112 QGEAR-EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKST 170
+ E R E R +AER + E+A R ++ EQ R+L+E+ ++ Q + Q ++
Sbjct: 717 EQERRREQERLQAERELQEREKALRLQK--EQLQRELEEKKKKEEQQRLAERQLQEEQEK 774
Query: 171 EQQLAA 176
+ + AA
Sbjct: 775 KAKEAA 780
Score = 36.6 bits (83), Expect = 0.035
Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 34/205 (16%)
Query: 56 LQLQKDNRDGRQRK--QELEKLMRGLEAESESLNQRLQDLSERERSL---------LRRR 104
L+ K R+ R RK Q E++ + E + + + Q+ + E+ +++
Sbjct: 563 LEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKK 622
Query: 105 SQAAQPLQGEAREAARERAERVR--RRLEEAERHKEDLEQHSRQLQEQW----------- 151
+ A + + EAR E A R+R ++ EE RH+E L++ + QE+
Sbjct: 623 AAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAE 682
Query: 152 ---EELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQD-ALQTA 207
+E Q E + Q+ EQ+ Q E +LAE + ++E+LQ + LQ
Sbjct: 683 QREQERREQERREQERREQERREQERREQ------ERQLAEQERRREQERLQAERELQER 736
Query: 208 EAWAIFQEQTVVLQVRPHSDAKEVQ 232
E Q++ + ++ +E Q
Sbjct: 737 EKALRLQKEQLQRELEEKKKKEEQQ 761
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.130 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,976,952
Number of Sequences: 37866
Number of extensions: 574818
Number of successful extensions: 10165
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 359
Number of HSP's successfully gapped in prelim test: 913
Number of HSP's that attempted gapping in prelim test: 4502
Number of HSP's gapped (non-prelim): 3874
length of query: 356
length of database: 18,247,518
effective HSP length: 103
effective length of query: 253
effective length of database: 14,347,320
effective search space: 3629871960
effective search space used: 3629871960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.