BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sapiens] (529 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 1093 0.0 gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 1093 0.0 gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 1093 0.0 gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 774 0.0 gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 758 0.0 gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 752 0.0 gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 716 0.0 gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 716 0.0 gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 690 0.0 gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 582 e-166 gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 556 e-158 gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 556 e-158 gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 553 e-157 gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 553 e-157 gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 545 e-155 gi|4503787 fyn-related kinase [Homo sapiens] 462 e-130 gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 364 e-101 gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 364 e-101 gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 364 e-101 gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 364 e-100 gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 363 e-100 gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 363 e-100 gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 363 e-100 gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 359 3e-99 gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 357 2e-98 gi|148596974 TXK tyrosine kinase [Homo sapiens] 320 2e-87 gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 310 3e-84 gi|130977759 tec protein tyrosine kinase [Homo sapiens] 309 5e-84 gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 305 9e-83 gi|187475373 c-src tyrosine kinase [Homo sapiens] 285 6e-77 >gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sapiens] Length = 529 Score = 1093 bits (2826), Expect = 0.0 Identities = 529/529 (100%), Positives = 529/529 (100%) Query: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA 60 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA Sbjct: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA 60 Query: 61 INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL 120 INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL Sbjct: 61 INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL 120 Query: 121 SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY 180 SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY Sbjct: 121 SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY 180 Query: 181 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP 240 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP Sbjct: 181 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP 240 Query: 241 CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP 300 CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP Sbjct: 241 CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP 300 Query: 301 KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV 360 KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV Sbjct: 301 KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV 360 Query: 361 DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF 420 DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF Sbjct: 361 DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF 420 Query: 421 PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP 480 PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP Sbjct: 421 PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP 480 Query: 481 PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT 529 PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT Sbjct: 481 PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT 529 >gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sapiens] Length = 529 Score = 1093 bits (2826), Expect = 0.0 Identities = 529/529 (100%), Positives = 529/529 (100%) Query: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA 60 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA Sbjct: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA 60 Query: 61 INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL 120 INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL Sbjct: 61 INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL 120 Query: 121 SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY 180 SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY Sbjct: 121 SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY 180 Query: 181 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP 240 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP Sbjct: 181 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP 240 Query: 241 CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP 300 CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP Sbjct: 241 CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP 300 Query: 301 KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV 360 KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV Sbjct: 301 KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV 360 Query: 361 DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF 420 DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF Sbjct: 361 DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF 420 Query: 421 PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP 480 PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP Sbjct: 421 PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP 480 Query: 481 PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT 529 PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT Sbjct: 481 PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT 529 >gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapiens] Length = 529 Score = 1093 bits (2826), Expect = 0.0 Identities = 529/529 (100%), Positives = 529/529 (100%) Query: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA 60 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA Sbjct: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA 60 Query: 61 INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL 120 INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL Sbjct: 61 INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL 120 Query: 121 SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY 180 SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY Sbjct: 121 SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY 180 Query: 181 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP 240 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP Sbjct: 181 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP 240 Query: 241 CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP 300 CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP Sbjct: 241 CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP 300 Query: 301 KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV 360 KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV Sbjct: 301 KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV 360 Query: 361 DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF 420 DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF Sbjct: 361 DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF 420 Query: 421 PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP 480 PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP Sbjct: 421 PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP 480 Query: 481 PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT 529 PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT Sbjct: 481 PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT 529 >gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] Length = 534 Score = 774 bits (1998), Expect = 0.0 Identities = 383/537 (71%), Positives = 433/537 (80%), Gaps = 15/537 (2%) Query: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKAR-PASSFAHIPNYSNFSSQ 59 MGCV CK E +E G Y YG DPT P+ IPNY+NF + Sbjct: 1 MGCVQCKDKEATKLTEERDGSLNQSSGY----RYGTDPTPQHYPSFGVTSIPNYNNFHAA 56 Query: 60 A---------INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNT 110 +N +GT+R G GVTLF+ALYDYEARTEDDL+F KGEKF ILN++ Sbjct: 57 GGQGLTVFGGVNSSS-HTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSS 115 Query: 111 EGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLI 170 EGDWWEARSL++G+TG IPSNYVAPVDSIQAEEWYFGK+GRKDAERQLLS GNP+G FLI Sbjct: 116 EGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLI 175 Query: 171 RESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230 RESETTKGAYSLSIRDWD +GDHVKHYKIRKLD GGYYITTR QF ++Q+LVQHY E Sbjct: 176 RESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKA 235 Query: 231 DGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAV 290 DGLC L + PQT GLAKDAWE++R S+ LE++LG GCF +VWLGTWNG+TKVA+ Sbjct: 236 DGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAI 295 Query: 291 KTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPE 350 KTLKPGTMSP++FLEEAQ+MK L+HDKLVQLYAVVSEEPIYIVTE+M GSLLDFLK+ E Sbjct: 296 KTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGE 355 Query: 351 GQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDD 410 G+ L+LP LVDMAAQVA GMAY+ERMNYIHRDLR+ANILVG L CKIADFGLARLI+D+ Sbjct: 356 GRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDN 415 Query: 411 EYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQ 470 EY QG+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL+TKGR+PYPGMN REVLEQ Sbjct: 416 EYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQ 475 Query: 471 VEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527 VE+GY MPCP CP SL+E M W+ DPEERPTFEYLQSFLEDYFT+ EPQYQPG+ Sbjct: 476 VERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 532 >gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] Length = 537 Score = 758 bits (1958), Expect = 0.0 Identities = 379/540 (70%), Positives = 429/540 (79%), Gaps = 18/540 (3%) Query: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKAR-PASSFAHIPNYSNFSSQ 59 MGCV CK E +E G Y YG DPT P+ IPNY+NF + Sbjct: 1 MGCVQCKDKEATKLTEERDGSLNQSSGY----RYGTDPTPQHYPSFGVTSIPNYNNFHAA 56 Query: 60 A---------INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNT 110 +N +GT+R G GVTLF+ALYDYEARTEDDL+F KGEKF ILN++ Sbjct: 57 GGQGLTVFGGVNSSS-HTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSS 115 Query: 111 EGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLI 170 EGDWWEARSL++G+TG IPSNYVAPVDSIQAEEWYFGK+GRKDAERQLLS GNP+G FLI Sbjct: 116 EGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLI 175 Query: 171 RESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230 RESETTKGAYSLSIRDWD +GDHVKHYKIRKLD GGYYITTR QF ++Q+LVQHY E Sbjct: 176 RESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERA 235 Query: 231 DGLCNLLIAPCTIMKPQTLGLA---KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTK 287 GLC L+ PC P+ L+ KD WEI R S+ L +RLG G FG+VW+GTWNG+TK Sbjct: 236 AGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTK 295 Query: 288 VAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLK 347 VA+KTLKPGTMSP++FLEEAQ+MK L+HDKLVQLYAVVSEEPIYIVTE+M GSLLDFLK Sbjct: 296 VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLK 355 Query: 348 NPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLI 407 + EG+ L+LP LVDMAAQVA GMAY+ERMNYIHRDLR+ANILVG L CKIADFGLARLI Sbjct: 356 DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI 415 Query: 408 KDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREV 467 +D+EY QG+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL+TKGR+PYPGMN REV Sbjct: 416 EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREV 475 Query: 468 LEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527 LEQVE+GY MPCP CP SL+E M W+ DPEERPTFEYLQSFLEDYFT+ EPQYQPG+ Sbjct: 476 LEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 535 >gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] Length = 543 Score = 752 bits (1942), Expect = 0.0 Identities = 364/515 (70%), Positives = 421/515 (81%), Gaps = 18/515 (3%) Query: 30 AADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTI-----------------R 72 + HYG +PT P S + NFSS ++ P SG Sbjct: 28 SVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPA 87 Query: 73 GVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNY 132 G++G GVT+F+ALYDYEART +DL+F KGE+F I+NNTEGDWWEARS+++GK G IPSNY Sbjct: 88 GLTG-GVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNY 146 Query: 133 VAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRG 192 VAP DSIQAEEWYFGK+GRKDAER LL+PGN +G FL+RESETTKGAYSLSIRDWD+ RG Sbjct: 147 VAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRG 206 Query: 193 DHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLA 252 D+VKHYKIRKLD GGYYITTR QF+++Q+LV+HY E DGLC+ L C +KPQT GLA Sbjct: 207 DNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLA 266 Query: 253 KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKL 312 KDAWEI R S+ LE +LG GCFG+VW+GTWNG+TKVA+KTLKPGTM P+AFL+EAQ+MK Sbjct: 267 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKK 326 Query: 313 LRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAY 372 LRHDKLV LYAVVSEEPIYIVTEFM GSLLDFLK +G+ L+LPQLVDMAAQ+A+GMAY Sbjct: 327 LRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAY 386 Query: 373 MERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALF 432 +ERMNYIHRDLRAANILVGE L CKIADFGLARLI+D+EY QG+KFPIKWTAPEAAL+ Sbjct: 387 IERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 446 Query: 433 GRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAME 492 GRFTIKSDVWSFGIL TEL+TKGR+PYPGM REVLEQVE+GY MPCP GCP SL+E M Sbjct: 447 GRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMN 506 Query: 493 QTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527 W+ DP+ERPTFEY+QSFLEDYFT+ EPQYQPG+ Sbjct: 507 LCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGE 541 >gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sapiens] Length = 536 Score = 716 bits (1848), Expect = 0.0 Identities = 356/530 (67%), Positives = 418/530 (78%), Gaps = 10/530 (1%) Query: 8 KLEPVATAKEDAGLEGDFRSYGAADHYGP-DPTKARPASSFAHIPNYSNFSSQAINP--- 63 K +P ++ LE +GA P T ++PAS+ H + F+ A P Sbjct: 5 KSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLF 64 Query: 64 -GFLDSGTIR-----GVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117 GF S T+ G GVT F+ALYDYE+RTE DL+F KGE+ I+NNTEGDWW A Sbjct: 65 GGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLA 124 Query: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177 SLS+G+TG IPSNYVAP DSIQAEEWYFGKI R+++ER LL+ NP+G FL+RESETTK Sbjct: 125 HSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTK 184 Query: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237 GAY LS+ D+D +G +VKHYKIRKLD GG+YIT+R QFNS+Q+LV +Y + DGLC+ L Sbjct: 185 GAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL 244 Query: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297 C KPQT GLAKDAWEI R S+ LE +LG GCFG+VW+GTWNG+T+VA+KTLKPGT Sbjct: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGT 304 Query: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357 MSP+AFL+EAQVMK LRH+KLVQLYAVVSEEPIYIVTE+M GSLLDFLK G+ LRLP Sbjct: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364 Query: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417 QLVDMAAQ+A GMAY+ERMNY+HRDLRAANILVGE L CK+ADFGLARLI+D+EY QG Sbjct: 365 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 424 Query: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477 +KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL TKGR+PYPGM REVL+QVE+GY M Sbjct: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484 Query: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527 PCPP CP SL++ M Q WR +PEERPTFEYLQ+FLEDYFTS EPQYQPG+ Sbjct: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGE 534 >gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapiens] Length = 536 Score = 716 bits (1848), Expect = 0.0 Identities = 356/530 (67%), Positives = 418/530 (78%), Gaps = 10/530 (1%) Query: 8 KLEPVATAKEDAGLEGDFRSYGAADHYGP-DPTKARPASSFAHIPNYSNFSSQAINP--- 63 K +P ++ LE +GA P T ++PAS+ H + F+ A P Sbjct: 5 KSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLF 64 Query: 64 -GFLDSGTIR-----GVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117 GF S T+ G GVT F+ALYDYE+RTE DL+F KGE+ I+NNTEGDWW A Sbjct: 65 GGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLA 124 Query: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177 SLS+G+TG IPSNYVAP DSIQAEEWYFGKI R+++ER LL+ NP+G FL+RESETTK Sbjct: 125 HSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTK 184 Query: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237 GAY LS+ D+D +G +VKHYKIRKLD GG+YIT+R QFNS+Q+LV +Y + DGLC+ L Sbjct: 185 GAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL 244 Query: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297 C KPQT GLAKDAWEI R S+ LE +LG GCFG+VW+GTWNG+T+VA+KTLKPGT Sbjct: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGT 304 Query: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357 MSP+AFL+EAQVMK LRH+KLVQLYAVVSEEPIYIVTE+M GSLLDFLK G+ LRLP Sbjct: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364 Query: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417 QLVDMAAQ+A GMAY+ERMNY+HRDLRAANILVGE L CK+ADFGLARLI+D+EY QG Sbjct: 365 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 424 Query: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477 +KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL TKGR+PYPGM REVL+QVE+GY M Sbjct: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484 Query: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527 PCPP CP SL++ M Q WR +PEERPTFEYLQ+FLEDYFTS EPQYQPG+ Sbjct: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGE 534 >gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] Length = 482 Score = 690 bits (1781), Expect = 0.0 Identities = 354/537 (65%), Positives = 397/537 (73%), Gaps = 67/537 (12%) Query: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKAR-PASSFAHIPNYSNFSSQ 59 MGCV CK E +E G Y YG DPT P+ IPNY+NF + Sbjct: 1 MGCVQCKDKEATKLTEERDGSLNQSSGY----RYGTDPTPQHYPSFGVTSIPNYNNFHAA 56 Query: 60 A---------INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNT 110 +N +GT+R G GVTLF+ALYDYEARTEDDL+F KGEKF ILN++ Sbjct: 57 GGQGLTVFGGVNSSS-HTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSS 115 Query: 111 EGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLI 170 EGDWWEARSL++G+TG IPSNYVAPVDSIQAEEWYFGK+GRKDAERQLLS GNP+G FLI Sbjct: 116 EGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLI 175 Query: 171 RESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230 RESETTKGAYSLSIRDWD +GDHVKHYKIRKLD GGYYITTR QF ++Q+LVQHY Sbjct: 176 RESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYS--- 232 Query: 231 DGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAV 290 GTWNG+TKVA+ Sbjct: 233 -------------------------------------------------GTWNGNTKVAI 243 Query: 291 KTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPE 350 KTLKPGTMSP++FLEEAQ+MK L+HDKLVQLYAVVSEEPIYIVTE+M GSLLDFLK+ E Sbjct: 244 KTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGE 303 Query: 351 GQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDD 410 G+ L+LP LVDMAAQVA GMAY+ERMNYIHRDLR+ANILVG L CKIADFGLARLI+D+ Sbjct: 304 GRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDN 363 Query: 411 EYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQ 470 EY QG+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL+TKGR+PYPGMN REVLEQ Sbjct: 364 EYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQ 423 Query: 471 VEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527 VE+GY MPCP CP SL+E M W+ DPEERPTFEYLQSFLEDYFT+ EPQYQPG+ Sbjct: 424 VERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 480 >gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] Length = 526 Score = 582 bits (1499), Expect = e-166 Identities = 291/491 (59%), Positives = 367/491 (74%), Gaps = 18/491 (3%) Query: 34 YGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTE 93 Y PDPT S+ PN N ++ PG ++G+ + +ALYDYEA Sbjct: 51 YVPDPT-----STIKPGPNSHNSNT----PGIREAGSED-------IIVVALYDYEAIHH 94 Query: 94 DDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKD 153 +DL+F KG++ +L + G+WW+ARSL++ K G IPSNYVA VDS++ EEW+F I RKD Sbjct: 95 EDLSFQKGDQMVVLEES-GEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKD 153 Query: 154 AERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTR 213 AERQLL+PGN G+F+IR+SETTKG+YSLS+RD+D +GD VKHYKIR LD GG+YI+ R Sbjct: 154 AERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPR 213 Query: 214 VQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGC 273 F+++QELV HY + NDGLC L PC KPQ KDAWEI R S+ LE++LG G Sbjct: 214 STFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQK-PWEKDAWEIPRESLKLEKKLGAGQ 272 Query: 274 FGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIV 333 FG+VW+ T+N TKVAVKT+KPG+MS +AFL EA VMK L+HDKLV+L+AVV++EPIYI+ Sbjct: 273 FGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYII 332 Query: 334 TEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGER 393 TEFM GSLLDFLK+ EG LP+L+D +AQ+AEGMA++E+ NYIHRDLRAANILV Sbjct: 333 TEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSAS 392 Query: 394 LACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELIT 453 L CKIADFGLAR+I+D+EY +G+KFPIKWTAPEA FG FTIKSDVWSFGILL E++T Sbjct: 393 LVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVT 452 Query: 454 KGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLE 513 GRIPYPGM+ EV+ +E+GY MP P CP LY M + W+ PEERPTFEY+QS L+ Sbjct: 453 YGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLD 512 Query: 514 DYFTSAEPQYQ 524 D++T+ E QYQ Sbjct: 513 DFYTATESQYQ 523 >gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog isoform B [Homo sapiens] Length = 491 Score = 556 bits (1434), Expect = e-158 Identities = 272/445 (61%), Positives = 339/445 (76%), Gaps = 3/445 (0%) Query: 81 LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQ 140 + +ALY Y+ DDL+F KGEK +L G+WW+A+SL + K G IPSNYVA +++++ Sbjct: 46 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 104 Query: 141 AEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKI 200 EEW+F I RKDAERQLL+PGN GAFLIRESET KG++SLS+RD+D GD +KHYKI Sbjct: 105 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 164 Query: 201 RKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISR 260 R LD GGYYI+ R+ F + ++++HY + DGLC L C KPQ KDAWEI R Sbjct: 165 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQK-PWDKDAWEIPR 223 Query: 261 SSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQ 320 SI L +RLG G FG+VW+G +N STKVAVKTLKPGTMS +AFLEEA +MK L+HDKLV+ Sbjct: 224 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 283 Query: 321 LYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYI 379 LYAVV+ EEPIYI+TE+M GSLLDFLK+ EG + LP+L+D +AQ+AEGMAY+ER NYI Sbjct: 284 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 343 Query: 380 HRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKS 439 HRDLRAAN+LV E L CKIADFGLAR+I+D+EY +G+KFPIKWTAPEA FG FTIKS Sbjct: 344 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 403 Query: 440 DVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDP 499 DVWSFGILL E++T G+IPYPG +V+ + QGY MP CP LY+ M+ W+ Sbjct: 404 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 463 Query: 500 EERPTFEYLQSFLEDYFTSAEPQYQ 524 EERPTF+YLQS L+D++T+ E QYQ Sbjct: 464 EERPTFDYLQSVLDDFYTATEGQYQ 488 >gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog isoform A [Homo sapiens] Length = 512 Score = 556 bits (1434), Expect = e-158 Identities = 272/445 (61%), Positives = 339/445 (76%), Gaps = 3/445 (0%) Query: 81 LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQ 140 + +ALY Y+ DDL+F KGEK +L G+WW+A+SL + K G IPSNYVA +++++ Sbjct: 67 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 125 Query: 141 AEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKI 200 EEW+F I RKDAERQLL+PGN GAFLIRESET KG++SLS+RD+D GD +KHYKI Sbjct: 126 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 185 Query: 201 RKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISR 260 R LD GGYYI+ R+ F + ++++HY + DGLC L C KPQ KDAWEI R Sbjct: 186 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQK-PWDKDAWEIPR 244 Query: 261 SSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQ 320 SI L +RLG G FG+VW+G +N STKVAVKTLKPGTMS +AFLEEA +MK L+HDKLV+ Sbjct: 245 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 304 Query: 321 LYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYI 379 LYAVV+ EEPIYI+TE+M GSLLDFLK+ EG + LP+L+D +AQ+AEGMAY+ER NYI Sbjct: 305 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 364 Query: 380 HRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKS 439 HRDLRAAN+LV E L CKIADFGLAR+I+D+EY +G+KFPIKWTAPEA FG FTIKS Sbjct: 365 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 424 Query: 440 DVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDP 499 DVWSFGILL E++T G+IPYPG +V+ + QGY MP CP LY+ M+ W+ Sbjct: 425 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 484 Query: 500 EERPTFEYLQSFLEDYFTSAEPQYQ 524 EERPTF+YLQS L+D++T+ E QYQ Sbjct: 485 EERPTFDYLQSVLDDFYTATEGQYQ 509 >gi|112789548 lymphocyte-specific protein tyrosine kinase precursor [Homo sapiens] Length = 509 Score = 553 bits (1426), Expect = e-157 Identities = 269/468 (57%), Positives = 349/468 (74%), Gaps = 2/468 (0%) Query: 58 SQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117 S+ +P G+ S + L IAL+ YE + DL F KGE+ IL + G+WW+A Sbjct: 42 SEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKA 100 Query: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177 +SL++G+ G IP N+VA +S++ E W+F + RKDAERQLL+PGN G+FLIRESE+T Sbjct: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160 Query: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237 G++SLS+RD+DQ +G+ VKHYKIR LD GG+YI+ R+ F + ELV+HY +DGLC L Sbjct: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220 Query: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297 PC KPQ +D WE+ R ++ L RLG G FG+VW+G +NG TKVAVK+LK G+ Sbjct: 221 SRPCQTQKPQKPWW-EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGS 279 Query: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357 MSP AFL EA +MK L+H +LV+LYAVV++EPIYI+TE+M +GSL+DFLK P G L + Sbjct: 280 MSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTIN 339 Query: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417 +L+DMAAQ+AEGMA++E NYIHRDLRAANILV + L+CKIADFGLARLI+D+EY +G Sbjct: 340 KLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 399 Query: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477 +KFPIKWTAPEA +G FTIKSDVWSFGILLTE++T GRIPYPGM EV++ +E+GY M Sbjct: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459 Query: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQP 525 P CP LY+ M W+ PE+RPTF+YL+S LED+FT+ E QYQP Sbjct: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507 >gi|112789546 lymphocyte-specific protein tyrosine kinase precursor [Homo sapiens] Length = 509 Score = 553 bits (1426), Expect = e-157 Identities = 269/468 (57%), Positives = 349/468 (74%), Gaps = 2/468 (0%) Query: 58 SQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117 S+ +P G+ S + L IAL+ YE + DL F KGE+ IL + G+WW+A Sbjct: 42 SEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKA 100 Query: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177 +SL++G+ G IP N+VA +S++ E W+F + RKDAERQLL+PGN G+FLIRESE+T Sbjct: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160 Query: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237 G++SLS+RD+DQ +G+ VKHYKIR LD GG+YI+ R+ F + ELV+HY +DGLC L Sbjct: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220 Query: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297 PC KPQ +D WE+ R ++ L RLG G FG+VW+G +NG TKVAVK+LK G+ Sbjct: 221 SRPCQTQKPQKPWW-EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGS 279 Query: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357 MSP AFL EA +MK L+H +LV+LYAVV++EPIYI+TE+M +GSL+DFLK P G L + Sbjct: 280 MSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTIN 339 Query: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417 +L+DMAAQ+AEGMA++E NYIHRDLRAANILV + L+CKIADFGLARLI+D+EY +G Sbjct: 340 KLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 399 Query: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477 +KFPIKWTAPEA +G FTIKSDVWSFGILLTE++T GRIPYPGM EV++ +E+GY M Sbjct: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459 Query: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQP 525 P CP LY+ M W+ PE+RPTF+YL+S LED+FT+ E QYQP Sbjct: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507 >gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] Length = 505 Score = 545 bits (1403), Expect = e-155 Identities = 271/443 (61%), Positives = 336/443 (75%), Gaps = 5/443 (1%) Query: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142 +ALYDY A + DL KGEK +L T GDWW ARSL +G+ G +PSN+VA V+S++ E Sbjct: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122 Query: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202 W+F GRK+AERQLL+P N G+FLIRESET KGA+SLS++D T+G+ +KHYKIR Sbjct: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVT-TQGELIKHYKIRC 181 Query: 203 LDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSS 262 LD GGYYI+ R+ F S+Q LVQHY + DGLC L PC PQ A+D WEI R S Sbjct: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQN-PWAQDEWEIPRQS 240 Query: 263 ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLY 322 + L R+LG+G FG+VW+G + + KVA+KTLK GTMSP+AFL EA VMK L+H++LV+LY Sbjct: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300 Query: 323 AVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRD 382 AVV++EPIYIVTE+M G LLDFLK EG L LP+L+DM+AQ+AEGMAY+ERMN IHRD Sbjct: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360 Query: 383 LRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVW 442 LRAANILV E L CKIADFGLAR+I D EY +G+KFPIKWTAPEA FG FTIK+DVW Sbjct: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419 Query: 443 SFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYE-AMEQTWRLDPEE 501 SFG+LL E++T GR+PYPGM+ EV+ +E+GY MP P CP LY + + WR PEE Sbjct: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479 Query: 502 RPTFEYLQSFLEDYFTSAEPQYQ 524 RPTFE+LQS LED++T+ E QY+ Sbjct: 480 RPTFEFLQSVLEDFYTATERQYE 502 >gi|4503787 fyn-related kinase [Homo sapiens] Length = 505 Score = 462 bits (1189), Expect = e-130 Identities = 240/450 (53%), Positives = 303/450 (67%), Gaps = 20/450 (4%) Query: 82 FIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGC-------IPSNYVA 134 F+AL+DY+ART +DL+F G+K +L+ WW AR L + G IPSNYVA Sbjct: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106 Query: 135 PVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH 194 S+QAE W+FG IGR DAE+QLL N G+FLIRESE+ KG +SLS+ D G Sbjct: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAV 161 Query: 195 VKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCT-IMKPQTLGLAK 253 VKHY+I++LD GG+++T R F+++ E V HY + +DGLC L PC I P L+ Sbjct: 162 VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSY 221 Query: 254 ---DAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVM 310 D WEI R+SI L +RLG+G FG+VW G WN +T VAVKTLKPG+M P FL EAQ+M Sbjct: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281 Query: 311 KLLRHDKLVQLYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEG 369 K LRH KL+QLYAV + E+PIYI+TE M HGSL ++L+N G + L Q VDMAAQVA G Sbjct: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341 Query: 370 MAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIK---DDEYNPCQGSKFPIKWTA 426 MAY+E NYIHRDL A N+LVGE K+ADFGLAR+ K +D Y K P+KWTA Sbjct: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401 Query: 427 PEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPAS 486 PEA +F+IKSDVWSFGILL E+IT G++PY GM +V++ + Q Y +P P CP Sbjct: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461 Query: 487 LYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516 Y M + W +P+ERPTFE L+ LEDYF Sbjct: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF 491 >gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a [Homo sapiens] Length = 1130 Score = 364 bits (935), Expect = e-101 Identities = 197/452 (43%), Positives = 278/452 (61%), Gaps = 15/452 (3%) Query: 71 IRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEARSLSSGKTGCIP 129 + G S LF+ALYD+ A ++ L+ TKGEK +L N G+W EA++ + G +P Sbjct: 55 LAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG--QGWVP 112 Query: 130 SNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQ 189 SNY+ PV+S++ WY G + R AE L S N G+FL+RESE++ G S+S+R Sbjct: 113 SNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR---- 166 Query: 190 TRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIM-KPQT 248 V HY+I G Y+++ +FN++ ELV H+ V DGL L P KP Sbjct: 167 -YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTV 225 Query: 249 LGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTWNG-STKVAVKTLKPGTMSPKAFLE 305 G++ D WE+ R+ IT++ +LG G +G+V+ G W S VAVKTLK TM + FL+ Sbjct: 226 YGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK 285 Query: 306 EAQVMKLLRHDKLVQLYAVVSEEP-IYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAA 364 EA VMK ++H LVQL V + EP YI+TEFM +G+LLD+L+ Q++ L+ MA Sbjct: 286 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 345 Query: 365 QVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKW 424 Q++ M Y+E+ N+IHRDL A N LVGE K+ADFGL+RL+ D Y G+KFPIKW Sbjct: 346 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 405 Query: 425 TAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCP 484 TAPE+ + +F+IKSDVW+FG+LL E+ T G PYPG++ +V E +E+ Y M P GCP Sbjct: 406 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP 465 Query: 485 ASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516 +YE M W+ +P +RP+F + E F Sbjct: 466 EKVYELMRACWQWNPSDRPSFAEIHQAFETMF 497 >gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b [Homo sapiens] Length = 1149 Score = 364 bits (935), Expect = e-101 Identities = 197/452 (43%), Positives = 278/452 (61%), Gaps = 15/452 (3%) Query: 71 IRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEARSLSSGKTGCIP 129 + G S LF+ALYD+ A ++ L+ TKGEK +L N G+W EA++ + G +P Sbjct: 74 LAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG--QGWVP 131 Query: 130 SNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQ 189 SNY+ PV+S++ WY G + R AE L S N G+FL+RESE++ G S+S+R Sbjct: 132 SNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR---- 185 Query: 190 TRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIM-KPQT 248 V HY+I G Y+++ +FN++ ELV H+ V DGL L P KP Sbjct: 186 -YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTV 244 Query: 249 LGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTWNG-STKVAVKTLKPGTMSPKAFLE 305 G++ D WE+ R+ IT++ +LG G +G+V+ G W S VAVKTLK TM + FL+ Sbjct: 245 YGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK 304 Query: 306 EAQVMKLLRHDKLVQLYAVVSEEP-IYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAA 364 EA VMK ++H LVQL V + EP YI+TEFM +G+LLD+L+ Q++ L+ MA Sbjct: 305 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 364 Query: 365 QVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKW 424 Q++ M Y+E+ N+IHRDL A N LVGE K+ADFGL+RL+ D Y G+KFPIKW Sbjct: 365 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 424 Query: 425 TAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCP 484 TAPE+ + +F+IKSDVW+FG+LL E+ T G PYPG++ +V E +E+ Y M P GCP Sbjct: 425 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP 484 Query: 485 ASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516 +YE M W+ +P +RP+F + E F Sbjct: 485 EKVYELMRACWQWNPSDRPSFAEIHQAFETMF 516 >gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] Length = 1146 Score = 364 bits (935), Expect = e-101 Identities = 206/489 (42%), Positives = 288/489 (58%), Gaps = 23/489 (4%) Query: 36 PDPTKARPASSFAHIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTE 93 PD T+A H P + QA+N S + G + LF+ALYD+ A + Sbjct: 34 PDLTEA------LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGD 87 Query: 94 DDLTFTKGEKFHILN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRK 152 + L+ TKGEK +L N G+W E RS + G +PSNY+ PV+S++ WY G + R Sbjct: 88 NTLSITKGEKLRVLGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRS 145 Query: 153 DAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITT 212 AE L S N G+FL+RESE++ G S+S+R V HY+I G Y+T Sbjct: 146 AAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTA 198 Query: 213 RVQFNSVQELVQHYMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRL 269 +F+++ ELV H+ V DGL L P KP G++ D WE+ R+ IT++ +L Sbjct: 199 ESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKL 258 Query: 270 GTGCFGDVWLGTWNG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-E 327 G G +G+V++G W S VAVKTLK TM + FL+EA VMK ++H LVQL V + E Sbjct: 259 GGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLE 318 Query: 328 EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAAN 387 P YIVTE+M +G+LLD+L+ +++ L+ MA Q++ M Y+E+ N+IHRDL A N Sbjct: 319 PPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARN 378 Query: 388 ILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGIL 447 LVGE K+ADFGL+RL+ D Y G+KFPIKWTAPE+ + F+IKSDVW+FG+L Sbjct: 379 CLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVL 438 Query: 448 LTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEY 507 L E+ T G PYPG++ +V + +E+GY M P GCP +YE M W+ P +RP+F Sbjct: 439 LWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAE 498 Query: 508 LQSFLEDYF 516 E F Sbjct: 499 THQAFETMF 507 >gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] Length = 1182 Score = 364 bits (934), Expect = e-100 Identities = 213/523 (40%), Positives = 300/523 (57%), Gaps = 26/523 (4%) Query: 11 PVATAKEDAG--LEGDFRSYGAADHY------GPDPTKARPASSFA-HIPNYSNFSSQAI 61 P ++ AG E F + DH+ G + K +S A H P + QA+ Sbjct: 30 PSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQAL 89 Query: 62 NPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEAR 118 N S + G + LF+ALYD+ A ++ L+ TKGEK +L N G+W E R Sbjct: 90 NEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR 149 Query: 119 SLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKG 178 S + G +PSNY+ PV+S++ WY G + R AE L S N G+FL+RESE++ G Sbjct: 150 SKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPG 205 Query: 179 AYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLI 238 S+S+R V HY+I G Y+T +F+++ ELV H+ V DGL L Sbjct: 206 QLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLH 260 Query: 239 APCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTWNG-STKVAVKTLK 294 P KP G++ D WE+ R+ IT++ +LG G +G+V++G W S VAVKTLK Sbjct: 261 YPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK 320 Query: 295 PGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQD 353 TM + FL+EA VMK ++H LVQL V + E P YIVTE+M +G+LLD+L+ ++ Sbjct: 321 EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE 380 Query: 354 LRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYN 413 + L+ MA Q++ M Y+E+ N+IHRDL A N LVGE K+ADFGL+RL+ D Y Sbjct: 381 VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYT 440 Query: 414 PCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQ 473 G+KFPIKWTAPE+ + F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+ Sbjct: 441 AHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 500 Query: 474 GYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516 GY M P GCP +YE M W+ P +RP+F E F Sbjct: 501 GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 543 >gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] Length = 1167 Score = 363 bits (933), Expect = e-100 Identities = 202/476 (42%), Positives = 283/476 (59%), Gaps = 17/476 (3%) Query: 49 HIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHI 106 H P + QA+N S + G + LF+ALYD+ A ++ L+ TKGEK + Sbjct: 62 HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRV 121 Query: 107 LN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQ 165 L N G+W E RS + G +PSNY+ PV+S++ WY G + R AE L S N Sbjct: 122 LGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN-- 177 Query: 166 GAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQH 225 G+FL+RESE++ G S+S+R V HY+I G Y+T +F+++ ELV H Sbjct: 178 GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 232 Query: 226 YMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTW 282 + V DGL L P KP G++ D WE+ R+ IT++ +LG G +G+V++G W Sbjct: 233 HSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW 292 Query: 283 NG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHG 340 S VAVKTLK TM + FL+EA VMK ++H LVQL V + E P YIVTE+M +G Sbjct: 293 KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYG 352 Query: 341 SLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIAD 400 +LLD+L+ +++ L+ MA Q++ M Y+E+ N+IHRDL A N LVGE K+AD Sbjct: 353 NLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVAD 412 Query: 401 FGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYP 460 FGL+RL+ D Y G+KFPIKWTAPE+ + F+IKSDVW+FG+LL E+ T G PYP Sbjct: 413 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYP 472 Query: 461 GMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516 G++ +V + +E+GY M P GCP +YE M W+ P +RP+F E F Sbjct: 473 GIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 528 >gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] Length = 542 Score = 363 bits (933), Expect = e-100 Identities = 202/476 (42%), Positives = 283/476 (59%), Gaps = 17/476 (3%) Query: 49 HIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHI 106 H P + QA+N S + G + LF+ALYD+ A ++ L+ TKGEK + Sbjct: 56 HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRV 115 Query: 107 LN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQ 165 L N G+W E RS + G +PSNY+ PV+S++ WY G + R AE L S N Sbjct: 116 LGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN-- 171 Query: 166 GAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQH 225 G+FL+RESE++ G S+S+R V HY+I G Y+T +F+++ ELV H Sbjct: 172 GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 226 Query: 226 YMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTW 282 + V DGL L P KP G++ D WE+ R+ IT++ +LG G +G+V++G W Sbjct: 227 HSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW 286 Query: 283 NG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHG 340 S VAVKTLK TM + FL+EA VMK ++H LVQL V + E P YIVTE+M +G Sbjct: 287 KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYG 346 Query: 341 SLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIAD 400 +LLD+L+ +++ L+ MA Q++ M Y+E+ N+IHRDL A N LVGE K+AD Sbjct: 347 NLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVAD 406 Query: 401 FGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYP 460 FGL+RL+ D Y G+KFPIKWTAPE+ + F+IKSDVW+FG+LL E+ T G PYP Sbjct: 407 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYP 466 Query: 461 GMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516 G++ +V + +E+GY M P GCP +YE M W+ P +RP+F E F Sbjct: 467 GIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 522 >gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] Length = 1064 Score = 363 bits (933), Expect = e-100 Identities = 202/476 (42%), Positives = 283/476 (59%), Gaps = 17/476 (3%) Query: 49 HIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHI 106 H P + QA+N S + G + LF+ALYD+ A ++ L+ TKGEK + Sbjct: 62 HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRV 121 Query: 107 LN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQ 165 L N G+W E RS + G +PSNY+ PV+S++ WY G + R AE L S N Sbjct: 122 LGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN-- 177 Query: 166 GAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQH 225 G+FL+RESE++ G S+S+R V HY+I G Y+T +F+++ ELV H Sbjct: 178 GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 232 Query: 226 YMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTW 282 + V DGL L P KP G++ D WE+ R+ IT++ +LG G +G+V++G W Sbjct: 233 HSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW 292 Query: 283 NG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHG 340 S VAVKTLK TM + FL+EA VMK ++H LVQL V + E P YIVTE+M +G Sbjct: 293 KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYG 352 Query: 341 SLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIAD 400 +LLD+L+ +++ L+ MA Q++ M Y+E+ N+IHRDL A N LVGE K+AD Sbjct: 353 NLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVAD 412 Query: 401 FGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYP 460 FGL+RL+ D Y G+KFPIKWTAPE+ + F+IKSDVW+FG+LL E+ T G PYP Sbjct: 413 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYP 472 Query: 461 GMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516 G++ +V + +E+GY M P GCP +YE M W+ P +RP+F E F Sbjct: 473 GIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 528 >gi|18250298 src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites [Homo sapiens] Length = 488 Score = 359 bits (922), Expect = 3e-99 Identities = 193/435 (44%), Positives = 261/435 (60%), Gaps = 12/435 (2%) Query: 81 LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV--DS 138 LF+ALYD+ AR +L+ +G++ L G + R G +P +VA ++ Sbjct: 55 LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPET 114 Query: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHY 198 + + WYF + R A++ LLSP N GAFLIR SE++ G YSLS+R + V HY Sbjct: 115 LSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAK-----VCHY 169 Query: 199 KIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEI 258 ++ G Y+ F ++EL+ +Y + N L+ PC K +D WE Sbjct: 170 RVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPR----QDVWER 225 Query: 259 SRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKL 318 S L R+LG G FG+VW G W GS VA+K +K M +E Q +K LRH++L Sbjct: 226 PHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERL 285 Query: 319 VQLYAVVSE-EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMN 377 ++L+AV S EP+YIVTE M G+L FL PEG+ LRLP L+ A QVAEGM+Y+E Sbjct: 286 IRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQR 345 Query: 378 YIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTI 437 +HRDL A N+LV + LACK+ADFGLARL+KDD Y+P SK P+KWTAPEAA + F+ Sbjct: 346 VVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQ 405 Query: 438 KSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRL 497 KSDVWSFG+LL E+ T G+ PY GM E L+Q+ +GY +P P CPA +Y M + WR Sbjct: 406 KSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRS 465 Query: 498 DPEERPTFEYLQSFL 512 PEERP+F L+ L Sbjct: 466 SPEERPSFATLREKL 480 >gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] Length = 451 Score = 357 bits (915), Expect = 2e-98 Identities = 196/446 (43%), Positives = 275/446 (61%), Gaps = 17/446 (3%) Query: 82 FIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKT---GCIPSNYVAPVDS 138 ++ L+D+++RT+++L+F G+ FH+ E WW +G G +P NY+A ++ Sbjct: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72 Query: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHY 198 +++E W+FG I R +A R+L + GN GAFLIR SE Y LS+RD V+HY Sbjct: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRHY 127 Query: 199 KIRKLDMGGYYITTRVQFNSVQELVQHY--MEVNDGLCNLLIAPCTIMKPQTLGLAKDAW 256 KI + G ++ V F S+ ELV ++ ++ GL L APC +P+ L D W Sbjct: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGL--RLAAPCRKHEPEPLPHWDD-W 184 Query: 257 EISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLE-EAQVMKLLRH 315 E R TL R+LG+G FG+V+ G W +VA+K + + + L+ E Q MK LRH Sbjct: 185 ERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRH 244 Query: 316 DKLVQLYAVVSE-EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYME 374 ++ LYAVVS +P+YI+TE M GSLL+ L++ + + L + +L+D+A QVAEGM Y+E Sbjct: 245 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE 304 Query: 375 RMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGR 434 NYIHRDL A NILVGE CK+ DFGLARLIK+D Y P KWTAPEA G Sbjct: 305 SQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLS-HDHNIPYKWTAPEALSRGH 363 Query: 435 FTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQT 494 ++ KSDVWSFGILL E+ ++G++PYPGM+ E +V+ GY MPCP CP S+++ M Sbjct: 364 YSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTC 423 Query: 495 WRLDPEERPTFEYLQSFLEDYFTSAE 520 W DPE+RP F+ L+ L FTS E Sbjct: 424 WCRDPEQRPCFKALRERLSS-FTSYE 448 >gi|148596974 TXK tyrosine kinase [Homo sapiens] Length = 527 Score = 320 bits (821), Expect = 2e-87 Identities = 175/432 (40%), Positives = 255/432 (59%), Gaps = 11/432 (2%) Query: 84 ALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAP--VDSIQA 141 ALYD+ R +L + E++ IL WW+AR G G IPSNYV + +++ Sbjct: 89 ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYVTENKITNLEI 147 Query: 142 EEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSI-RDWDQTRGDHVKHYKI 200 EWY I R AE LL + +GAF++R+S G+Y++S+ ++ +KHY+I Sbjct: 148 YEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQI 205 Query: 201 RKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLGLAKDAWE 257 +K D G +Y+ R F S+ EL+ ++ GL L P +M P T G + + WE Sbjct: 206 KKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWE 265 Query: 258 ISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDK 317 I S + + +G+G FG V LG W +VA+K + G+MS + F+EEA+VM L H K Sbjct: 266 IDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSK 325 Query: 318 LVQLYAV-VSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERM 376 LVQLY V + +P+YIVTEFM +G LL++L+ +G+ LR L+ + + EGM Y+ER Sbjct: 326 LVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYLERN 384 Query: 377 NYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFT 436 YIHRDL A N LV KI+DFG+ R + DDEY G+KFPIKW+ PE LF +++ Sbjct: 385 GYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYS 444 Query: 437 IKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWR 496 KSDVWSFG+L+ E+ T+G++P+ + +V+E + +G+ + P P S+YE M W Sbjct: 445 SKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWH 504 Query: 497 LDPEERPTFEYL 508 PE RPTF L Sbjct: 505 EKPEGRPTFAEL 516 >gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] Length = 659 Score = 310 bits (793), Expect = 3e-84 Identities = 167/440 (37%), Positives = 254/440 (57%), Gaps = 14/440 (3%) Query: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV-DSIQA 141 +ALYDY +DL KG+++ IL + WW AR +G+ G IPSNYV DSI+ Sbjct: 220 VALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIEM 278 Query: 142 EEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH---VKHY 198 EWY + R AE QLL +G F++R+S G Y++S+ + ++ GD ++HY Sbjct: 279 YEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDSSKA-GKYTVSV--FAKSTGDPQGVIRHY 334 Query: 199 KIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLGLAKDA 255 + YY+ + F+++ EL+ ++ + GL + L P + P T GL + Sbjct: 335 VVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGS 394 Query: 256 WEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRH 315 WEI +T + LGTG FG V G W G VA+K +K G+MS F+EEA+VM L H Sbjct: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454 Query: 316 DKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYME 374 +KLVQLY V +++ PI+I+TE+M +G LL++L+ + + QL++M V E M Y+E Sbjct: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAMEYLE 513 Query: 375 RMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGR 434 ++HRDL A N LV ++ K++DFGL+R + DDEY GSKFP++W+ PE ++ + Sbjct: 514 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 573 Query: 435 FTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQT 494 F+ KSD+W+FG+L+ E+ + G++PY E E + QG + P +Y M Sbjct: 574 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC 633 Query: 495 WRLDPEERPTFEYLQSFLED 514 W +ERPTF+ L S + D Sbjct: 634 WHEKADERPTFKILLSNILD 653 >gi|130977759 tec protein tyrosine kinase [Homo sapiens] Length = 631 Score = 309 bits (791), Expect = 5e-84 Identities = 174/443 (39%), Positives = 255/443 (57%), Gaps = 13/443 (2%) Query: 81 LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDS-- 138 + +A+YD++A DL +G+++ IL + WW AR G G IPSNYV S Sbjct: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241 Query: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH-VKH 197 + EWY + R AE QLL + +G F++R+S + G Y++S+ G +H Sbjct: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299 Query: 198 YKIRKLDMGG--YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIM---KPQTLGLA 252 Y I++ YY+ + F S+ E+++++ GL L P ++ P T G + Sbjct: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359 Query: 253 KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKL 312 + WEI+ S +T R LG+G FG V LG W KVA+K ++ G M + F+EEA+VM Sbjct: 360 YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMK 419 Query: 313 LRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMA 371 L H KLVQLY V +++ PIYIVTEFM G LL+FL+ +G R L+ M V EGM Sbjct: 420 LTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGME 478 Query: 372 YMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAAL 431 Y+ER ++IHRDL A N LV E K++DFG+AR + DD+Y G+KFP+KW PE Sbjct: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538 Query: 432 FGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAM 491 + RF+ KSDVWSFG+L+ E+ T+GR+P+ EV+ V +G+ + P +YE M Sbjct: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598 Query: 492 EQTWRLDPEERPTFEYLQSFLED 514 + W+ PE RP+FE L +++ Sbjct: 599 LRCWQEKPEGRPSFEDLLRTIDE 621 >gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] Length = 620 Score = 305 bits (780), Expect = 9e-83 Identities = 168/439 (38%), Positives = 249/439 (56%), Gaps = 14/439 (3%) Query: 80 TLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV--D 137 T+ IALYDY+ +L + E++ +L+++E WW + +G G +PS+Y+ + Sbjct: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHEGYVPSSYLVEKSPN 232 Query: 138 SIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSI--RDWDQTRGDHV 195 +++ EWY I R AE+ LL G +GAF++R+S T G Y++S+ + + Sbjct: 233 NLETYEWYNKSISRDKAEKLLLDTGK-EGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290 Query: 196 KHYKIRKLDMGG--YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLG 250 KHY I++ + YY+ + F+S+ L+ ++ GL L P + P T G Sbjct: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350 Query: 251 LAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVM 310 L W I S +T + +G+G FG V LG W KVA+KT++ G MS + F+EEA+VM Sbjct: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410 Query: 311 KLLRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEG 369 L H KLVQLY V E+ PI +V EFM HG L D+L+ G L+ M V EG Sbjct: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL-FAAETLLGMCLDVCEG 469 Query: 370 MAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEA 429 MAY+E IHRDL A N LVGE K++DFG+ R + DD+Y G+KFP+KW +PE Sbjct: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529 Query: 430 ALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYE 489 F R++ KSDVWSFG+L+ E+ ++G+IPY + EV+E + G+ + P +Y+ Sbjct: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589 Query: 490 AMEQTWRLDPEERPTFEYL 508 M W+ PE+RP F L Sbjct: 590 IMNHCWKERPEDRPAFSRL 608 >gi|187475373 c-src tyrosine kinase [Homo sapiens] Length = 450 Score = 285 bits (730), Expect = 6e-77 Identities = 174/442 (39%), Positives = 243/442 (54%), Gaps = 26/442 (5%) Query: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142 IA Y++ E DL F KG+ I+ T+ W G+ G IP+NYV + ++A Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74 Query: 143 E------WYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVK 196 W+ GKI R+ AER L P G FL+RES G Y+L + + V+ Sbjct: 75 TKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCV-----SCDGKVE 127 Query: 197 HYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLG---LAK 253 HY+I I V F ++ +LV+HY DGLC LI P +M+ + Sbjct: 128 HYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKP-KVMEGTVAAQDEFYR 185 Query: 254 DAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLL 313 W ++ + L + +G G FGDV LG + G+ KVAVK +K + +AFL EA VM L Sbjct: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMTQL 243 Query: 314 RHDKLVQLYAVVSEEP--IYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMA 371 RH LVQL V+ EE +YIVTE+M GSL+D+L++ L L+ + V E M Sbjct: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 Query: 372 YMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAAL 431 Y+E N++HRDL A N+LV E K++DFGL + + K P+KWTAPEA Sbjct: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ----DTGKLPVKWTAPEALR 359 Query: 432 FGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAM 491 +F+ KSDVWSFGILL E+ + GR+PYP + ++V+ +VE+GY M P GCP ++YE M Sbjct: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 419 Query: 492 EQTWRLDPEERPTFEYLQSFLE 513 + W LD RP+F L+ LE Sbjct: 420 KNCWHLDAAMRPSFLQLREQLE 441 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.136 0.422 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 21,368,704 Number of Sequences: 37866 Number of extensions: 984508 Number of successful extensions: 4606 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 775 Number of HSP's successfully gapped in prelim test: 302 Number of HSP's that attempted gapping in prelim test: 2224 Number of HSP's gapped (non-prelim): 1370 length of query: 529 length of database: 18,247,518 effective HSP length: 107 effective length of query: 422 effective length of database: 14,195,856 effective search space: 5990651232 effective search space used: 5990651232 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.