Guide to the Human Genome
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Search of human proteins with 11225266

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11225266 transient receptor potential cation channel,
subfamily M, member 5 [Homo sapiens]
         (1165 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11225266 transient receptor potential cation channel, subfami...  2351   0.0  
gi|21314671 transient receptor potential cation channel, subfami...   919   0.0  
gi|4507689 transient receptor potential cation channel, subfamil...   758   0.0  
gi|109689695 transient receptor potential cation channel, subfam...   571   e-162
gi|154091314 transient receptor potential cation channel, subfam...   470   e-132
gi|154091316 transient receptor potential cation channel, subfam...   466   e-131
gi|154091318 transient receptor potential cation channel, subfam...   466   e-131
gi|154091312 transient receptor potential cation channel, subfam...   465   e-130
gi|154091320 transient receptor potential cation channel, subfam...   465   e-130
gi|154091310 transient receptor potential cation channel, subfam...   460   e-129
gi|154091308 transient receptor potential cation channel, subfam...   459   e-129
gi|18921093 transient receptor potential cation channel, subfami...   427   e-119
gi|148612863 transient receptor potential cation channel, subfam...   418   e-116
gi|94538366 transient receptor potential cation channel, subfami...   316   9e-86
gi|45935368 transient receptor potential cation channel, subfami...   125   2e-28
gi|55953096 transient receptor potential cation channel, subfami...   120   1e-26
gi|6912736 transient receptor potential cation channel, subfamil...    69   3e-11
gi|209863032 transient receptor potential cation channel, subfam...    65   4e-10
gi|209863030 transient receptor potential cation channel, subfam...    65   4e-10
gi|209863026 transient receptor potential cation channel, subfam...    65   4e-10
gi|209863024 transient receptor potential cation channel, subfam...    65   4e-10
gi|7706747 transient receptor potential cation channel, subfamil...    65   4e-10
gi|22547184 transient receptor potential cation channel, subfami...    58   5e-08
gi|21735483 transient receptor potential cation channel, subfami...    52   4e-06
gi|22547180 transient receptor potential cation channel, subfami...    51   6e-06
gi|5730102 transient receptor potential cation channel, subfamil...    49   4e-05
gi|209863028 transient receptor potential cation channel, subfam...    47   1e-04
gi|9966865 transient receptor potential cation channel, subfamil...    46   2e-04
gi|194733735 transient receptor potential cation channel, subfam...    45   3e-04
gi|4507687 transient receptor potential cation channel, subfamil...    45   3e-04

>gi|11225266 transient receptor potential cation channel, subfamily M,
            member 5 [Homo sapiens]
          Length = 1165

 Score = 2351 bits (6093), Expect = 0.0
 Identities = 1165/1165 (100%), Positives = 1165/1165 (100%)

Query: 1    MQDVQGPRPGSPGDAEDRRELGLHRGEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEW 60
            MQDVQGPRPGSPGDAEDRRELGLHRGEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEW
Sbjct: 1    MQDVQGPRPGSPGDAEDRRELGLHRGEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEW 60

Query: 61   HLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAV 120
            HLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAV
Sbjct: 61   HLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAV 120

Query: 121  RDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNL 180
            RDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNL
Sbjct: 121  RDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNL 180

Query: 181  SHFILVEPGPPGKGDGLTELRLRLEKHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERI 240
            SHFILVEPGPPGKGDGLTELRLRLEKHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERI
Sbjct: 181  SHFILVEPGPPGKGDGLTELRLRLEKHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERI 240

Query: 241  SRAVEQAAPWLILVGSGGIADVLAALVNQPHLLVPKVAEKQFKEKFPSKHFSWEDIVRWT 300
            SRAVEQAAPWLILVGSGGIADVLAALVNQPHLLVPKVAEKQFKEKFPSKHFSWEDIVRWT
Sbjct: 241  SRAVEQAAPWLILVGSGGIADVLAALVNQPHLLVPKVAEKQFKEKFPSKHFSWEDIVRWT 300

Query: 301  KLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDR 360
            KLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDR
Sbjct: 301  KLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDR 360

Query: 361  VDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYR 420
            VDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYR
Sbjct: 361  VDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYR 420

Query: 421  SVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRG 480
            SVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRG
Sbjct: 421  SVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRG 480

Query: 481  FYQDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAM 540
            FYQDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAM
Sbjct: 481  FYQDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAM 540

Query: 541  GQEGVAAALAACKILKEMSHLETEAEAARATREAKYERLALDLFSECYSNSEARAFALLV 600
            GQEGVAAALAACKILKEMSHLETEAEAARATREAKYERLALDLFSECYSNSEARAFALLV
Sbjct: 541  GQEGVAAALAACKILKEMSHLETEAEAARATREAKYERLALDLFSECYSNSEARAFALLV 600

Query: 601  RRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALV 660
            RRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALV
Sbjct: 601  RRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALV 660

Query: 661  YTNLITFSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFL 720
            YTNLITFSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFL
Sbjct: 661  YTNLITFSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFL 720

Query: 721  LTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVL 780
            LTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVL
Sbjct: 721  LTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVL 780

Query: 781  EEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAM 840
            EEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAM
Sbjct: 781  EEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAM 840

Query: 841  DFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDG 900
            DFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDG
Sbjct: 841  DFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDG 900

Query: 901  RLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLV 960
            RLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLV
Sbjct: 901  RLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLV 960

Query: 961  TFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHL 1020
            TFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHL
Sbjct: 961  TFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHL 1020

Query: 1021 SLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRK 1080
            SLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRK
Sbjct: 1021 SLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRK 1080

Query: 1081 TAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQGGGPRSSQHCGEGSQ 1140
            TAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQGGGPRSSQHCGEGSQ
Sbjct: 1081 TAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQGGGPRSSQHCGEGSQ 1140

Query: 1141 LVAADHRGGLDGWEQPGAGQPPSDT 1165
            LVAADHRGGLDGWEQPGAGQPPSDT
Sbjct: 1141 LVAADHRGGLDGWEQPGAGQPPSDT 1165


>gi|21314671 transient receptor potential cation channel, subfamily M,
            member 4 [Homo sapiens]
          Length = 1214

 Score =  919 bits (2375), Expect = 0.0
 Identities = 523/1148 (45%), Positives = 700/1148 (60%), Gaps = 63/1148 (5%)

Query: 26   GEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLR 85
            GE++F G+G+K   F+R+     P+ ++ L+   W   APNLVVS++G      +++WL+
Sbjct: 76   GELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQ 135

Query: 86   DVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRV 145
            D+LR+GLV+AAQSTGAWI+T  L  G+ RHVG AVRDH +AST    +VVA+G+A  G V
Sbjct: 136  DLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGG-TKVVAMGVAPWGVV 194

Query: 146  LHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLE 205
             +R  L   +  FP  Y        G    LD N S F LV+ G  G   G    RLRLE
Sbjct: 195  RNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLE 254

Query: 206  KHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGIADVLAA 265
             +IS+Q+ G GGTG I+IPVL LL++GD   L RI  A +   P L++ GSGG AD LA 
Sbjct: 255  SYISQQKTGVGGTG-IDIPVLLLLIDGDEKMLTRIENATQAQLPCLLVAGSGGAADCLAE 313

Query: 266  LVNQPHLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYDFEQEGSEE 325
             +          A +        + F   D+      ++ I + + LLTVY  E +GSEE
Sbjct: 314  TLEDTLAPGSGGARQGEARDRIRRFFPKGDLEVLQAQVERIMTRKELLTVYSSE-DGSEE 372

Query: 326  LDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMV 385
             +T++LKALVKAC S   E   YLDEL+LAVAW+RVDIA+SE+F GD++W+S  LE  ++
Sbjct: 373  FETIVLKALVKACGS--SEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLM 430

Query: 386  DALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQEEARLTLAG 445
            DAL++++PEFVRL + +G  +  FLT  RL +LY +    SL+ +LL +    A      
Sbjct: 431  DALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSLIRNLLDQASHSAGTKAPA 490

Query: 446  L--GTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQDGRPGDRRRAEK-GPAKRPT 502
            L  G  + R P          +V  VL+  L   C   Y  G   D    +  G +    
Sbjct: 491  LKGGAAELRPP----------DVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLL 540

Query: 503  GQKWLLDLNQKS---ENPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMS 559
              K    L+  +   + PW DL LWA+L NR +MA YFW MG   V++AL AC +L+ M+
Sbjct: 541  SDKATSPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMA 600

Query: 560  HLETEAEAARATREA--KYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATE 617
             LE +AE A   ++   K+E + +DLF ECY +SE RA  LL+RR   W   TCL LA +
Sbjct: 601  RLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQ 660

Query: 618  ADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALVYTNLITF--SEEAPLRT 675
            ADA+AFFA DGVQ+ LT+ WWGDMA+ TPI  L+ AF CP L+YT LITF  SEE P R 
Sbjct: 661  ADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLIYTRLITFRKSEEEPTRE 720

Query: 676  GLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGP-----RAVFLLTRWRKFWGA 730
             LE   D+DS+   + P+       +  +  PR  G  G           L RW  FWGA
Sbjct: 721  ELEF--DMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCLRRWFHFWGA 778

Query: 731  PVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTD 790
            PVT+F+GNVV Y  FL LF+ VLLVDF+P P  P   E+ LYFW FTL+ EE+RQG    
Sbjct: 779  PVTIFMGNVVSYLLFLLLFSRVLLVDFQPAP--PGSLELLLYFWAFTLLCEELRQGLSGG 836

Query: 791  EDT-----------HLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLA 839
              +            L ++  LY+ D+WN+CD+VA+  F++GV CR+ P  +  GRTVL 
Sbjct: 837  GGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLC 896

Query: 840  MDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHD 899
            +DFMVFT+RL+HIF ++KQLGPKI++V +MMKDVFFFLFFL VWLVAYGV T+ LL P D
Sbjct: 897  IDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRD 956

Query: 900  GRLEWIFRRVLYRPYLQIFGQIPLDEIDEARV---NCSTHPLLLEDSP-----SCPSLYA 951
                 I RRV YRPYLQIFGQIP +++D A +   NCS+ P      P     +C S YA
Sbjct: 957  SDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYA 1016

Query: 952  NWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALA 1011
            NWLV+LLLV FLLV N+LL+NLLIAMFSYTF  VQGN+D++WK QRY LI E+H RPALA
Sbjct: 1017 NWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALA 1076

Query: 1012 PPFILLSHLSLTLRRVFKK-----EAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKM 1066
            PPFI++SHL L LR++ ++      +    EH    L    ++K++TWE+V KENFL   
Sbjct: 1077 PPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLAR 1136

Query: 1067 EKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQG 1126
             + +R+S+ E L++T+ +VD   K LG +RE E+R+K LE ++  CS ++  VA+ L++ 
Sbjct: 1137 ARDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLGWVAEALSRS 1196

Query: 1127 -----GGP 1129
                 GGP
Sbjct: 1197 ALLPPGGP 1204


>gi|4507689 transient receptor potential cation channel, subfamily M,
            member 2 [Homo sapiens]
          Length = 1503

 Score =  758 bits (1958), Expect = 0.0
 Identities = 458/1172 (39%), Positives = 653/1172 (55%), Gaps = 104/1172 (8%)

Query: 26   GEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLR 85
            G++ F G  +K  K+VRV      SV++ L+   W L  PNL++S+ G  + F MK  L+
Sbjct: 128  GDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNFNMKPRLK 187

Query: 86   DVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRV 145
             + R+GLVK AQ+TGAWI+T     G+ + VG+AVRD SL+S+  +  ++ +G+A+ G V
Sbjct: 188  SIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTV 247

Query: 146  LHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLE 205
              R  L      FP  Y  D+ G QG L  LDSN SHFILV+ G  G+      LR RLE
Sbjct: 248  HRREGLIHPTGSFPAEYILDEDG-QGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLE 306

Query: 206  KHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGIADVLAA 265
            K ISEQ    GG  +I+IP++C+++ G P TL  I  A     P +++ GSG +ADV+A 
Sbjct: 307  KFISEQTKERGGV-AIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRVADVIAQ 365

Query: 266  LVNQP--HLLVPKVAEKQ---FKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYDFEQ 320
            + N P   + +  + +K    F+E F +  F+   IV WTK +Q+I   + LLTV+   +
Sbjct: 366  VANLPVSDITISLIQQKLSVFFQEMFET--FTESRIVEWTKKIQDIVRRRQLLTVFREGK 423

Query: 321  EGSEELDTVILKALVKACKSHSQEPQDYLD-ELKLAVAWDRVDIAKSEIFNGDVEWKSCD 379
            +G +++D  IL+AL+KA +S      +  D +LKLAVAW+RVDIA+SEIF  + +WK  D
Sbjct: 424  DGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWKPSD 483

Query: 380  LEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQEEA 439
            L   M  AL+SNKPEFV+LF++NG  + +F+T+  L  LY ++    L    LQ+     
Sbjct: 484  LHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCLFHSKLQK----- 538

Query: 440  RLTLAGLGTQQAREPPAGP--PAFSLHEVSRVLKDFLQDACRGFYQDGRPGDRRR--AEK 495
                  +  +    P   P  P   +H V++VL++ L D  +  Y   R  DR R     
Sbjct: 539  ------VLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPV 592

Query: 496  GPAKRPTGQKWLLDLNQKSE-------NPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAA 548
               K       L  L ++S        +P RDL +WA++QNR E+A   WA  Q+ +AAA
Sbjct: 593  PHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAA 652

Query: 549  LAACKILKEMSHLE--TEAEAARATREAKYERLALDLFSECYSNSEARAFALLVRRNRCW 606
            LA  KILKE+S  E  T++         +YE  A+ +F+ECY   E RA  LL R +  W
Sbjct: 653  LACSKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAW 712

Query: 607  SKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALVYTNLIT 666
             KTTCL LA EA    F +H G+QAFLT++WWG ++    + R+    L   L+ T LI+
Sbjct: 713  GKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCMLAFPLLLTGLIS 772

Query: 667  FSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFLLTRWRK 726
            F E+         LQD                     V  P A             R R 
Sbjct: 773  FREKR--------LQD---------------------VGTPAA-------------RARA 790

Query: 727  FWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQG 786
            F+ APV VF  N++ YFAFL LF YVL+VDF+P    PS  E  +Y W+F+LV EE+RQ 
Sbjct: 791  FFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPV---PSWCECAIYLWLFSLVCEEMRQL 847

Query: 787  FFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAMDFMVFT 846
            F+  ++  L+KK  LY  D WNK D+ AI LF+ G+TCR++P+    GR +L++DF++F 
Sbjct: 848  FYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFC 907

Query: 847  LRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIF 906
            LRL+HIF I K LGPKII+V+RMMKDVFFFLF L+VW+V++GV  QA+L  ++ R++W+F
Sbjct: 908  LRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWLF 967

Query: 907  RRVLYRPYLQIFGQIP--LDEIDEARVNCS---THPLLLEDSPSCPS--------LYANW 953
            R  +Y  YL IFGQIP  +D ++    +CS   T P      P CP          +  W
Sbjct: 968  RGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPY----KPKCPESDATQQRPAFPEW 1023

Query: 954  LVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPP 1013
            L +LLL  +LL TN+LL+NLLIAMF+YTFQ VQ + D  WKFQR++LI EYH RPA  PP
Sbjct: 1024 LTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPP 1083

Query: 1014 FILLSHLSLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDS 1073
            FILLSHL L ++RV  K    + + L+  L    +  +++WE   KEN+L   + +++  
Sbjct: 1084 FILLSHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQKQR 1143

Query: 1074 EGEVLRKTAHRVDFIAKYLG-----GLREQEKRIKCLESQINYCSVLVSSVADVLAQGGG 1128
              + +   +++VD +   L           E+R+  LE Q+   +  +  +   L   G 
Sbjct: 1144 PEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTARALHWIVRTLRASGF 1203

Query: 1129 PRSSQHCGEGSQLVAAD---HRGGLDGWEQPG 1157
               +      SQ  A +     GG    E+PG
Sbjct: 1204 SSEADVPTLASQKAAEEPDAEPGGRKKTEEPG 1235


>gi|109689695 transient receptor potential cation channel, subfamily
            M, member 8 [Homo sapiens]
          Length = 1104

 Score =  571 bits (1472), Expect = e-162
 Identities = 374/1103 (33%), Positives = 577/1103 (52%), Gaps = 127/1103 (11%)

Query: 26   GEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLR 85
            G++ F   GKK GK++R+       +L++LL   WHL  PNLV+S+ G  + FA+K  +R
Sbjct: 104  GDIQFETLGKK-GKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMR 162

Query: 86   DVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRV 145
             +  + L+  AQS GAWILT     GL +++G+ VRD+++ S S++  +VA+G+A+ G V
Sbjct: 163  KIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTI-SRSSEENIVAIGIAAWGMV 220

Query: 146  LHRRILE---EAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRL 202
             +R  L    +A+  F   Y  DD  ++ PL  LD+N +H +LV+ G  G      +LR 
Sbjct: 221  SNRDTLIRNCDAEGYFLAQYLMDDF-TRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRN 279

Query: 203  RLEKHISE---QRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGI 259
            +LEK+ISE   Q + YGG    +IP++C    G   TL+ I+ +++   P +++ GSG I
Sbjct: 280  QLEKYISERTIQDSNYGG----KIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQI 335

Query: 260  ADVLAALVNQPHLLVPKVAEKQFKEKFPS--KHFSWEDIVRWTKLLQNITSHQHLLTVYD 317
            ADV+A+LV     L     +++     P        E+   W K L+ I    HLLTV  
Sbjct: 336  ADVIASLVEVEDALTSSAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIK 395

Query: 318  FEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKS 377
             E+ G E +   I  AL KA  +  Q+  ++  +LKL + W+++D+A  EIF  D  W+S
Sbjct: 396  MEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWES 455

Query: 378  CDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQ---R 434
             DL+EVM  AL+ ++P+FVRLF++NG ++  FLT+  L EL+ S    +L++  LQ    
Sbjct: 456  ADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELF-SNHFSTLVYRNLQIAKN 514

Query: 435  KQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQDGRPGDRRRAE 494
               +A LT                       V +++ +F     RGF ++ R G      
Sbjct: 515  SYNDALLTF----------------------VWKLVANFR----RGFRKEDRNG------ 542

Query: 495  KGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKI 554
                 R      L D++  + +P + LF+WA+LQN+ E++   W   +    AAL A K+
Sbjct: 543  -----RDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKL 597

Query: 555  LKEMSHLETEAEAARATREA--KYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCL 612
            LK ++ ++ +  AA  + E   +YE  A++LF+ECYS+ E  A  LLV     W  + CL
Sbjct: 598  LKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCL 657

Query: 613  HLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALVYTNLITFSEEAP 672
             LA EA  + F A  GVQ FL++ W+G+++  T   +++       LV    ++F ++  
Sbjct: 658  ELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKK-- 715

Query: 673  LRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFLLTRWRKFWGAPV 732
                         +D  K                             LL  +  F+ +P 
Sbjct: 716  ------------PVDKHKK----------------------------LLWYYVAFFTSPF 735

Query: 733  TVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDED 792
             VF  NVV Y AFL LF YVLL+DF   P     PE+ LY  VF L  +E+RQ +    +
Sbjct: 736  VVFSWNVVFYIAFLLLFAYVLLMDFHSVPH---PPELVLYSLVFVLFCDEVRQWYVNGVN 792

Query: 793  THLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRM---LPSAFEAGRTVLAMDFMVFTLRL 849
                     Y  D WN  D + +F FI G+  R+     S+  +GR +  +D+++FTLRL
Sbjct: 793  ---------YFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRL 843

Query: 850  IHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRV 909
            IHIF + + LGPKII+++RM+ DVFFFLF  +VW+VA+GV  Q +L  ++ R  WIFR V
Sbjct: 844  IHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSV 903

Query: 910  LYRPYLQIFGQIPLDEIDEAR---VNCS-----THPLLLE-DSPSCPSLYANWLVILLLV 960
            +Y PYL +FGQ+P D +D       +C+     + PL +E D  + P  +  W+ I L+ 
Sbjct: 904  IYEPYLAMFGQVPSD-VDGTTYDFAHCTFTGNESKPLCVELDEHNLPR-FPEWITIPLVC 961

Query: 961  TFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHL 1020
             ++L TN+LL+NLL+AMF YT   VQ N D  WKFQRY L+ EY  R  +  PFI+ ++ 
Sbjct: 962  IYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAYF 1021

Query: 1021 SLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRK 1080
             + +++ FK   + K            D + + WE V KEN+L K+  +  D+  E+  +
Sbjct: 1022 YMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRHR 1081

Query: 1081 TAHRVDFIAKYLGGLREQEKRIK 1103
                   +    G L+E   +IK
Sbjct: 1082 FRQLDTKLNDLKGLLKEIANKIK 1104


>gi|154091314 transient receptor potential cation channel, subfamily
            M, member 3 isoform k [Homo sapiens]
          Length = 1707

 Score =  470 bits (1209), Expect = e-132
 Identities = 348/1159 (30%), Positives = 567/1159 (48%), Gaps = 136/1159 (11%)

Query: 26   GEVNFGGSG-KKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWL 84
            G + F G G   +  +VRV     P +L  L+  EW L  P L++S+ G  Q F ++  L
Sbjct: 140  GTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKL 199

Query: 85   RDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGR 144
            + V  KGL+KAA +TGAWI T  +  G+ RHVG A++DH+   + ++ ++  +G+A  G 
Sbjct: 200  KQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDHA---SKSRGKICTIGIAPWGI 256

Query: 145  VLHRRILEEAQEDF----PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTEL 200
            V       E QED      V   +        L  L+S  SHFIL + G  GK     +L
Sbjct: 257  V-------ENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKL 309

Query: 201  RLRLEKHISEQ----RAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV-- 254
            R +LEKHIS Q    R G G      +PV+ L+V G PN +  +   +    P  ++V  
Sbjct: 310  RRQLEKHISLQKINTRIGQG------VPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCD 363

Query: 255  GSGGIADVLA---------ALVNQP---HLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKL 302
            GSG  +D+LA          L+N+     LLV    +K F        ++         +
Sbjct: 364  GSGRASDILAFGHKYSEEGGLINESLRDQLLV--TIQKTFT-------YTRTQAQHLFII 414

Query: 303  LQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVD 362
            L      + L+TV+    EG +++D  IL AL+K   + +       D+L LA+AW+RVD
Sbjct: 415  LMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAP------DQLSLALAWNRVD 468

Query: 363  IAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSV 422
            IA+S+IF    +W    LE+ M+DALV ++ +FV+L ++NG  +  FLT  RL+ELY + 
Sbjct: 469  IARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTR 528

Query: 423  SRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAF--SLHEVSRVLKDFLQDACRG 480
               S     L R  ++  L                PP +  SL ++  V++  +  A R 
Sbjct: 529  HGPSNTLYHLVRDVKKGNL----------------PPDYRISLIDIGLVIEYLMGGAYRC 572

Query: 481  FYQDGRPGDRRRAEKGPAKRPTGQKWL-----------------------LDLNQKSEN- 516
             Y   R         GP KRP   K L                       +DL+    N 
Sbjct: 573  NYTRKRFRTLYHNLFGP-KRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINH 631

Query: 517  ---PWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAARATRE 573
               P+ +L +WAVL  R +MA +FW  G+E +A AL ACK+ K M+H  +E +      +
Sbjct: 632  FPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQ 691

Query: 574  A------KYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHD 627
                    + +LA++L  + Y   E  A  LL    + WS  TCL LA  A  + F AH 
Sbjct: 692  ELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHT 751

Query: 628  GVQAFLTRIWWGD--MAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLED--LQDL 683
              Q  LT +W G   M   + +  +LG  L P+++        ++ P  +  ++  LQ+ 
Sbjct: 752  CSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKN-KDDMPYMSQAQEIHLQEK 810

Query: 684  DSLDTEKSPLYGLQSRVEELVEAPRAQGDRGP-----------RAVFLLTRWRKFWGAPV 732
            ++ + EK      +  +E      R  G+              R + L  +  +F+ AP+
Sbjct: 811  EAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPI 870

Query: 733  TVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDED 792
              F    + Y  +L LF Y++LV      + PS  E  +  ++FTL +E++R+     E 
Sbjct: 871  VKFWFYTLAYIGYLMLFNYIVLVKME---RWPSTQEWIVISYIFTLGIEKMRE-ILMSEP 926

Query: 793  THLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTLRLIH 851
              L++K  +++ + WN  D++AI LF VG+  R+    F + GR +  ++ + + +RL+ 
Sbjct: 927  GKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLD 986

Query: 852  IFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLY 911
            IF ++K LGP ++++ +MM D+ +F+  + V L+++GV  QA+L P++     + + + Y
Sbjct: 987  IFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFY 1046

Query: 912  RPYLQIFGQIPLDEIDE-ARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLL 970
             PY  I+G++  D+ID     N +     +   P C +    W+V  ++  +LLV N+LL
Sbjct: 1047 MPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKT--GAWIVPAIMACYLLVANILL 1104

Query: 971  MNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKK 1030
            +NLLIA+F+ TF  V+  ++  WKFQRY LI+ +HERP L PP I+ SH+++  + +  +
Sbjct: 1105 VNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCR 1164

Query: 1031 EAEHKREHLERD------LPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHR 1084
              +H+ +  ERD      + D   +KV  +E    E +  + + R   S  E +R T+ R
Sbjct: 1165 WRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSER 1224

Query: 1085 VDFIAKYLGGLREQEKRIK 1103
            V+ ++  L  + E+E  +K
Sbjct: 1225 VENMSMRLEEVNEREHSMK 1243


>gi|154091316 transient receptor potential cation channel, subfamily
            M, member 3 isoform e [Homo sapiens]
          Length = 1556

 Score =  466 bits (1199), Expect = e-131
 Identities = 343/1135 (30%), Positives = 563/1135 (49%), Gaps = 115/1135 (10%)

Query: 40   FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99
            +VRV     P +L  L+  EW L  P L++S+ G  Q F ++  L+ V  KGL+KAA +T
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 100  GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158
            GAWI T  +  G+ RHVG A++DH   ++ ++ ++  +G+A  G V       E QED  
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDH---ASKSRGKICTIGIAPWGIV-------ENQEDLI 111

Query: 159  ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQ---- 211
                V   +        L  L+S  SHFIL + G  GK     +LR +LEKHIS Q    
Sbjct: 112  GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171

Query: 212  RAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGGIADVLA----- 264
            R G G      +PV+ L+V G PN +  +   +    P  ++V  GSG  +D+LA     
Sbjct: 172  RIGQG------VPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKY 225

Query: 265  ----ALVNQ---PHLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYD 317
                 L+N+     LLV    +K F        ++         +L      + L+TV+ 
Sbjct: 226  SEEGGLINESLRDQLLV--TIQKTFT-------YTRTQAQHLFIILMECMKKKELITVFR 276

Query: 318  FEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKS 377
               EG +++D  IL AL+K   + +       D+L LA+AW+RVDIA+S+IF    +W  
Sbjct: 277  MGSEGHQDIDLAILTALLKGANASAP------DQLSLALAWNRVDIARSQIFIYGQQWPV 330

Query: 378  CDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQE 437
              LE+ M+DALV ++ +FV+L ++NG  +  FLT  RL+ELY +    S     L R  +
Sbjct: 331  GSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVK 390

Query: 438  EARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFY--------------- 482
            +      G    +   PP      SL ++  V++  +  A R  Y               
Sbjct: 391  KREYPGFGWIYFKGNLPP--DYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGP 448

Query: 483  -QDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSEN----PWRDLFLWAVLQNRHEMATYF 537
             +D  P   RR  K   KR   ++  +DL+    N    P+ +L +WAVL  R +MA +F
Sbjct: 449  KRDDIP--LRRGRKTTKKRE--EEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFF 504

Query: 538  WAMGQEGVAAALAACKILKEMSHLETEAEAARATRE------AKYERLALDLFSECYSNS 591
            W  G+E +A AL ACK+ K M+H  +E +      +        + +LA++L  + Y   
Sbjct: 505  WQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQD 564

Query: 592  EARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWG--DMAAGTPILR 649
            E  A  LL    + WS  TCL LA  A  + F AH   Q  LT +W G   M   + +  
Sbjct: 565  EQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKV 624

Query: 650  LLGAFLCPALVYTNLITFSEEAPLRTGLED--LQDLDSLDTEKSPLYGLQSRVEELVEAP 707
            +LG  L P+++        ++ P  +  ++  LQ+ ++ + EK      +  +E      
Sbjct: 625  ILGILLPPSILSLEFKN-KDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLG 683

Query: 708  RAQGDRG-----------PRAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVD 756
            R  G+              R + L  +  +F+ AP+  F    + Y  +L LF Y++LV 
Sbjct: 684  RNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVK 743

Query: 757  FRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIF 816
                 + PS  E  +  ++FTL +E++R+     E   L++K  +++ + WN  D++AI 
Sbjct: 744  ME---RWPSTQEWIVISYIFTLGIEKMRE-ILMSEPGKLLQKVKVWLQEYWNVTDLIAIL 799

Query: 817  LFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFF 875
            LF VG+  R+    F + GR +  ++ + + +RL+ IF ++K LGP ++++ +MM D+ +
Sbjct: 800  LFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMY 859

Query: 876  FLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEID-EARVNCS 934
            F+  + V L+++GV  QA+L P++     + + + Y PY  I+G++  D+ID     N +
Sbjct: 860  FVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNET 919

Query: 935  THPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWK 994
                 +   P C +    W+V  ++  +LLV N+LL+NLLIA+F+ TF  V+  ++  WK
Sbjct: 920  REDGKIIQLPPCKT--GAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWK 977

Query: 995  FQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERD------LPDPLD 1048
            FQRY LI+ +HERP L PP I+ SH+++  + +  +  +H+ +  ERD      + D   
Sbjct: 978  FQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDEL 1037

Query: 1049 QKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKRIK 1103
            +KV  +E    E +  + + R   S  E +R T+ RV+ ++  L  + E+E  +K
Sbjct: 1038 KKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMK 1092


>gi|154091318 transient receptor potential cation channel, subfamily
            M, member 3 isoform d [Homo sapiens]
          Length = 1544

 Score =  466 bits (1198), Expect = e-131
 Identities = 343/1137 (30%), Positives = 563/1137 (49%), Gaps = 131/1137 (11%)

Query: 40   FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99
            +VRV     P +L  L+  EW L  P L++S+ G  Q F ++  L+ V  KGL+KAA +T
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 100  GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158
            GAWI T  +  G+ RHVG A++DH+   + ++ ++  +G+A  G V       E QED  
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHA---SKSRGKICTIGIAPWGIV-------ENQEDLI 111

Query: 159  ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQ---- 211
                V   +        L  L+S  SHFIL + G  GK     +LR +LEKHIS Q    
Sbjct: 112  GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171

Query: 212  RAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGGIADVLA----- 264
            R G G      +PV+ L+V G PN +  +   +    P  ++V  GSG  +D+LA     
Sbjct: 172  RIGQG------VPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKY 225

Query: 265  ----ALVNQP---HLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYD 317
                 L+N+     LLV    +K F        ++         +L      + L+TV+ 
Sbjct: 226  SEEGGLINESLRDQLLV--TIQKTFT-------YTRTQAQHLFIILMECMKKKELITVFR 276

Query: 318  FEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKS 377
               EG +++D  IL AL+K   + +       D+L LA+AW+RVDIA+S+IF    +W  
Sbjct: 277  MGSEGHQDIDLAILTALLKGANASAP------DQLSLALAWNRVDIARSQIFIYGQQWPV 330

Query: 378  CDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQE 437
              LE+ M+DALV ++ +FV+L ++NG  +  FLT  RL+ELY +    S     L R  +
Sbjct: 331  GSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVK 390

Query: 438  EARLTLAGLGTQQAREPPAGPPAF--SLHEVSRVLKDFLQDACRGFY------------- 482
            +  L                PP +  SL ++  V++  +  A R  Y             
Sbjct: 391  KGNL----------------PPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLF 434

Query: 483  ---QDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSEN----PWRDLFLWAVLQNRHEMAT 535
               +D  P   RR  K   KR   ++  +DL+    N    P+ +L +WAVL  R +MA 
Sbjct: 435  GPKRDDIP--LRRGRKTTKKRE--EEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMAL 490

Query: 536  YFWAMGQEGVAAALAACKILKEMSHLETEAEAARATREA------KYERLALDLFSECYS 589
            +FW  G+E +A AL ACK+ K M+H  +E +      +        + +LA++L  + Y 
Sbjct: 491  FFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYK 550

Query: 590  NSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGD--MAAGTPI 647
              E  A  LL    + WS  TCL LA  A  + F AH   Q  LT +W G   M   + +
Sbjct: 551  QDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGL 610

Query: 648  LRLLGAFLCPALVYTNLITFSEEAPLRTGLED--LQDLDSLDTEKSPLYGLQSRVEELVE 705
              +LG  L P+++        ++ P  +  ++  LQ+ ++ + EK      +  +E    
Sbjct: 611  KVILGILLPPSILSLEFKN-KDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAM 669

Query: 706  APRAQGDRGP-----------RAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLL 754
              R  G+              R + L  +  +F+ AP+  F    + Y  +L LF Y++L
Sbjct: 670  LGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVL 729

Query: 755  VDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVA 814
            V      + PS  E  +  ++FTL +E++R+     E   L++K  +++ + WN  D++A
Sbjct: 730  VKME---RWPSTQEWIVISYIFTLGIEKMRE-ILMSEPGKLLQKVKVWLQEYWNVTDLIA 785

Query: 815  IFLFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDV 873
            I LF VG+  R+    F + GR +  ++ + + +RL+ IF ++K LGP ++++ +MM D+
Sbjct: 786  ILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDM 845

Query: 874  FFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDE-ARVN 932
             +F+  + V L+++GV  QA+L P++     + + + Y PY  I+G++  D+ID     N
Sbjct: 846  MYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQN 905

Query: 933  CSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMF 992
             +     +   P C +    W+V  ++  +LLV N+LL+NLLIA+F+ TF  V+  ++  
Sbjct: 906  ETREDGKIIQLPPCKT--GAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQV 963

Query: 993  WKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERD------LPDP 1046
            WKFQRY LI+ +HERP L PP I+ SH+++  + +  +  +H+ +  ERD      + D 
Sbjct: 964  WKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDD 1023

Query: 1047 LDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKRIK 1103
              +KV  +E    E +  + + R   S  E +R T+ RV+ ++  L  + E+E  +K
Sbjct: 1024 ELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMK 1080


>gi|154091312 transient receptor potential cation channel, subfamily
            M, member 3 isoform b [Homo sapiens]
          Length = 1566

 Score =  465 bits (1197), Expect = e-130
 Identities = 344/1142 (30%), Positives = 561/1142 (49%), Gaps = 119/1142 (10%)

Query: 40   FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99
            +VRV     P +L  L+  EW L  P L++S+ G  Q F ++  L+ V  KGL+KAA +T
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 100  GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158
            GAWI T  +  G+ RHVG A++DH+   + ++ ++  +G+A  G V       E QED  
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHA---SKSRGKICTIGIAPWGIV-------ENQEDLI 111

Query: 159  ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQ---- 211
                V   +        L  L+S  SHFIL + G  GK     +LR +LEKHIS Q    
Sbjct: 112  GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171

Query: 212  RAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGGIADVLA----- 264
            R G G      +PV+ L+V G PN +  +   +    P  ++V  GSG  +D+LA     
Sbjct: 172  RIGQG------VPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKY 225

Query: 265  ----ALVNQP---HLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYD 317
                 L+N+     LLV    +K F        ++         +L      + L+TV+ 
Sbjct: 226  SEEGGLINESLRDQLLV--TIQKTFT-------YTRTQAQHLFIILMECMKKKELITVFR 276

Query: 318  FEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKS 377
               EG +++D  IL AL+K   + +       D+L LA+AW+RVDIA+S+IF    +W  
Sbjct: 277  MGSEGHQDIDLAILTALLKGANASAP------DQLSLALAWNRVDIARSQIFIYGQQWPV 330

Query: 378  CDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQE 437
              LE+ M+DALV ++ +FV+L ++NG  +  FLT  RL+ELY +    S     L R  +
Sbjct: 331  GSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVK 390

Query: 438  EARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQDGRPGDRRRAEKGP 497
            +      G    +   PP      SL ++  V++  +  A R  Y   R         GP
Sbjct: 391  KREYPGFGWIYFKGNLPP--DYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGP 448

Query: 498  AKRPTGQKWL-----------------------LDLNQKSEN----PWRDLFLWAVLQNR 530
             KRP   K L                       +DL+    N    P+ +L +WAVL  R
Sbjct: 449  -KRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKR 507

Query: 531  HEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAARATREA------KYERLALDLF 584
             +MA +FW  G+E +A AL ACK+ K M+H  +E +      +        + +LA++L 
Sbjct: 508  QKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELL 567

Query: 585  SECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGD--MA 642
             + Y   E  A  LL    + WS  TCL LA  A  + F AH   Q  LT +W G   M 
Sbjct: 568  DQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMR 627

Query: 643  AGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLED--LQDLDSLDTEKSPLYGLQSRV 700
              + +  +LG  L P+++        ++ P  +  ++  LQ+ ++ + EK      +  +
Sbjct: 628  KNSGLKVILGILLPPSILSLEFKN-KDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDM 686

Query: 701  EELVEAPRAQGDRGP-----------RAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLF 749
            E      R  G+              R + L  +  +F+ AP+  F    + Y  +L LF
Sbjct: 687  ELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLF 746

Query: 750  TYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNK 809
             Y++LV      + PS  E  +  ++FTL +E++R+     E   L++K  +++ + WN 
Sbjct: 747  NYIVLVKME---RWPSTQEWIVISYIFTLGIEKMRE-ILMSEPGKLLQKVKVWLQEYWNV 802

Query: 810  CDMVAIFLFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVER 868
             D++AI LF VG+  R+    F + GR +  ++ + + +RL+ IF ++K LGP ++++ +
Sbjct: 803  TDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGK 862

Query: 869  MMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDE 928
            MM D+ +F+  + V L+++GV  QA+L P++     + + + Y PY  I+G++  D+ID 
Sbjct: 863  MMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDP 922

Query: 929  -ARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQG 987
                N +     +   P C +    W+V  ++  +LLV N+LL+NLLIA+F+ TF  V+ 
Sbjct: 923  PCGQNETREDGKIIQLPPCKT--GAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKS 980

Query: 988  NADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERD----- 1042
             ++  WKFQRY LI+ +HERP L PP I+ SH+++  + +  +  +H+ +  ERD     
Sbjct: 981  ISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKL 1040

Query: 1043 -LPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKR 1101
             + D   +KV  +E    E +  + + R   S  E +R T+ RV+ ++  L  + E+E  
Sbjct: 1041 FITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHS 1100

Query: 1102 IK 1103
            +K
Sbjct: 1101 MK 1102


>gi|154091320 transient receptor potential cation channel, subfamily
            M, member 3 isoform a [Homo sapiens]
          Length = 1554

 Score =  465 bits (1196), Expect = e-130
 Identities = 344/1144 (30%), Positives = 561/1144 (49%), Gaps = 135/1144 (11%)

Query: 40   FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99
            +VRV     P +L  L+  EW L  P L++S+ G  Q F ++  L+ V  KGL+KAA +T
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 100  GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158
            GAWI T  +  G+ RHVG A++DH+   + ++ ++  +G+A  G V       E QED  
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHA---SKSRGKICTIGIAPWGIV-------ENQEDLI 111

Query: 159  ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQ---- 211
                V   +        L  L+S  SHFIL + G  GK     +LR +LEKHIS Q    
Sbjct: 112  GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171

Query: 212  RAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGGIADVLA----- 264
            R G G      +PV+ L+V G PN +  +   +    P  ++V  GSG  +D+LA     
Sbjct: 172  RIGQG------VPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKY 225

Query: 265  ----ALVNQP---HLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYD 317
                 L+N+     LLV    +K F        ++         +L      + L+TV+ 
Sbjct: 226  SEEGGLINESLRDQLLV--TIQKTFT-------YTRTQAQHLFIILMECMKKKELITVFR 276

Query: 318  FEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKS 377
               EG +++D  IL AL+K   + +       D+L LA+AW+RVDIA+S+IF    +W  
Sbjct: 277  MGSEGHQDIDLAILTALLKGANASAP------DQLSLALAWNRVDIARSQIFIYGQQWPV 330

Query: 378  CDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQE 437
              LE+ M+DALV ++ +FV+L ++NG  +  FLT  RL+ELY +    S     L R  +
Sbjct: 331  GSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVK 390

Query: 438  EARLTLAGLGTQQAREPPAGPPAF--SLHEVSRVLKDFLQDACRGFYQDGRPGDRRRAEK 495
            +  L                PP +  SL ++  V++  +  A R  Y   R         
Sbjct: 391  KGNL----------------PPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLF 434

Query: 496  GPAKRPTGQKWL-----------------------LDLNQKSEN----PWRDLFLWAVLQ 528
            GP KRP   K L                       +DL+    N    P+ +L +WAVL 
Sbjct: 435  GP-KRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLM 493

Query: 529  NRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAARATREA------KYERLALD 582
             R +MA +FW  G+E +A AL ACK+ K M+H  +E +      +        + +LA++
Sbjct: 494  KRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVE 553

Query: 583  LFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGD-- 640
            L  + Y   E  A  LL    + WS  TCL LA  A  + F AH   Q  LT +W G   
Sbjct: 554  LLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR 613

Query: 641  MAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLED--LQDLDSLDTEKSPLYGLQS 698
            M   + +  +LG  L P+++        ++ P  +  ++  LQ+ ++ + EK      + 
Sbjct: 614  MRKNSGLKVILGILLPPSILSLEFKN-KDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEE 672

Query: 699  RVEELVEAPRAQGDRGP-----------RAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLF 747
             +E      R  G+              R + L  +  +F+ AP+  F    + Y  +L 
Sbjct: 673  DMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLM 732

Query: 748  LFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNW 807
            LF Y++LV      + PS  E  +  ++FTL +E++R+     E   L++K  +++ + W
Sbjct: 733  LFNYIVLVKME---RWPSTQEWIVISYIFTLGIEKMRE-ILMSEPGKLLQKVKVWLQEYW 788

Query: 808  NKCDMVAIFLFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVV 866
            N  D++AI LF VG+  R+    F + GR +  ++ + + +RL+ IF ++K LGP ++++
Sbjct: 789  NVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMI 848

Query: 867  ERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEI 926
             +MM D+ +F+  + V L+++GV  QA+L P++     + + + Y PY  I+G++  D+I
Sbjct: 849  GKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQI 908

Query: 927  DE-ARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVV 985
            D     N +     +   P C +    W+V  ++  +LLV N+LL+NLLIA+F+ TF  V
Sbjct: 909  DPPCGQNETREDGKIIQLPPCKT--GAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEV 966

Query: 986  QGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERD--- 1042
            +  ++  WKFQRY LI+ +HERP L PP I+ SH+++  + +  +  +H+ +  ERD   
Sbjct: 967  KSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGL 1026

Query: 1043 ---LPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQE 1099
               + D   +KV  +E    E +  + + R   S  E +R T+ RV+ ++  L  + E+E
Sbjct: 1027 KLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNERE 1086

Query: 1100 KRIK 1103
              +K
Sbjct: 1087 HSMK 1090


>gi|154091310 transient receptor potential cation channel, subfamily
            M, member 3 isoform g [Homo sapiens]
          Length = 1569

 Score =  460 bits (1184), Expect = e-129
 Identities = 343/1156 (29%), Positives = 565/1156 (48%), Gaps = 144/1156 (12%)

Query: 40   FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99
            +VRV     P +L  L+  EW L  P L++S+ G  Q F ++  L+ V  KGL+KAA +T
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 100  GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158
            GAWI T  +  G+ RHVG A++DH+   + ++ ++  +G+A  G V       E QED  
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHA---SKSRGKICTIGIAPWGIV-------ENQEDLI 111

Query: 159  ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQRAG- 214
                V   +        L  L+S  SHFIL + G  GK     +LR +LEKHIS Q+   
Sbjct: 112  GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171

Query: 215  -------------YGGTGSIE---------IPVLCLLVNGDPNTLERISRAVEQAAPWLI 252
                         Y   GS +         +PV+ L+V G PN +  +   +    P  +
Sbjct: 172  RCLPFFSLDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPV 231

Query: 253  LV--GSGGIADVLA---------ALVNQP---HLLVPKVAEKQFKEKFPSKHFSWEDIVR 298
            +V  GSG  +D+LA          L+N+     LLV    +K F        ++      
Sbjct: 232  VVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLV--TIQKTFT-------YTRTQAQH 282

Query: 299  WTKLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAW 358
               +L      + L+TV+    EG +++D  IL AL+K   + +       D+L LA+AW
Sbjct: 283  LFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAP------DQLSLALAW 336

Query: 359  DRVDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQEL 418
            +RVDIA+S+IF    +W    LE+ M+DALV ++ +FV+L ++NG  +  FLT  RL+EL
Sbjct: 337  NRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEEL 396

Query: 419  YRSVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAF--SLHEVSRVLKDFLQD 476
            Y +    S     L R  ++  L                PP +  SL ++  V++  +  
Sbjct: 397  YNTRHGPSNTLYHLVRDVKKGNL----------------PPDYRISLIDIGLVIEYLMGG 440

Query: 477  ACRGFY----------------QDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSEN---- 516
            A R  Y                +D  P   RR  K   KR   ++  +DL+    N    
Sbjct: 441  AYRCNYTRKRFRTLYHNLFGPKRDDIP--LRRGRKTTKKRE--EEVDIDLDDPEINHFPF 496

Query: 517  PWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAARATREA-- 574
            P+ +L +WAVL  R +MA +FW  G+E +A AL ACK+ K M+H  +E +      +   
Sbjct: 497  PFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELN 556

Query: 575  ----KYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQ 630
                 + +LA++L  + Y   E  A  LL    + WS  TCL LA  A  + F AH   Q
Sbjct: 557  HNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQ 616

Query: 631  AFLTRIWWGD--MAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLED--LQDLDSL 686
              LT +W G   M   + +  +LG  L P+++        ++ P  +  ++  LQ+ ++ 
Sbjct: 617  MLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKN-KDDMPYMSQAQEIHLQEKEAE 675

Query: 687  DTEKSPLYGLQSRVEELVEAPRAQGDRGP-----------RAVFLLTRWRKFWGAPVTVF 735
            + EK      +  +E      R  G+              R + L  +  +F+ AP+  F
Sbjct: 676  EPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKF 735

Query: 736  LGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHL 795
                + Y  +L LF Y++LV      + PS  E  +  ++FTL +E++R+     E   L
Sbjct: 736  WFYTLAYIGYLMLFNYIVLVKME---RWPSTQEWIVISYIFTLGIEKMRE-ILMSEPGKL 791

Query: 796  VKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTLRLIHIFA 854
            ++K  +++ + WN  D++AI LF VG+  R+    F + GR +  ++ + + +RL+ IF 
Sbjct: 792  LQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFG 851

Query: 855  IHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPY 914
            ++K LGP ++++ +MM D+ +F+  + V L+++GV  QA+L P++     + + + Y PY
Sbjct: 852  VNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPY 911

Query: 915  LQIFGQIPLDEIDE-ARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNL 973
              I+G++  D+ID     N +     +   P C +    W+V  ++  +LLV N+LL+NL
Sbjct: 912  WMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKT--GAWIVPAIMACYLLVANILLVNL 969

Query: 974  LIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAE 1033
            LIA+F+ TF  V+  ++  WKFQRY LI+ +HERP L PP I+ SH+++  + +  +  +
Sbjct: 970  LIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRK 1029

Query: 1034 HKREHLERD------LPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDF 1087
            H+ +  ERD      + D   +KV  +E    E +  + + R   S  E +R T+ RV+ 
Sbjct: 1030 HESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVEN 1089

Query: 1088 IAKYLGGLREQEKRIK 1103
            ++  L  + E+E  +K
Sbjct: 1090 MSMRLEEVNEREHSMK 1105


>gi|154091308 transient receptor potential cation channel, subfamily
            M, member 3 isoform f [Homo sapiens]
          Length = 1579

 Score =  459 bits (1182), Expect = e-129
 Identities = 344/1163 (29%), Positives = 563/1163 (48%), Gaps = 148/1163 (12%)

Query: 40   FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99
            +VRV     P +L  L+  EW L  P L++S+ G  Q F ++  L+ V  KGL+KAA +T
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 100  GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158
            GAWI T  +  G+ RHVG A++DH+   + ++ ++  +G+A  G V       E QED  
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHA---SKSRGKICTIGIAPWGIV-------ENQEDLI 111

Query: 159  ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQRAG- 214
                V   +        L  L+S  SHFIL + G  GK     +LR +LEKHIS Q+   
Sbjct: 112  GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171

Query: 215  -------------YGGTGSIE---------IPVLCLLVNGDPNTLERISRAVEQAAPWLI 252
                         Y   GS +         +PV+ L+V G PN +  +   +    P  +
Sbjct: 172  RCLPFFSLDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPV 231

Query: 253  LV--GSGGIADVLA---------ALVNQP---HLLVPKVAEKQFKEKFPSKHFSWEDIVR 298
            +V  GSG  +D+LA          L+N+     LLV    +K F        ++      
Sbjct: 232  VVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLV--TIQKTFT-------YTRTQAQH 282

Query: 299  WTKLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAW 358
               +L      + L+TV+    EG +++D  IL AL+K   + +       D+L LA+AW
Sbjct: 283  LFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAP------DQLSLALAW 336

Query: 359  DRVDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQEL 418
            +RVDIA+S+IF    +W    LE+ M+DALV ++ +FV+L ++NG  +  FLT  RL+EL
Sbjct: 337  NRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEEL 396

Query: 419  YRSVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAF--SLHEVSRVLKDFLQD 476
            Y +    S     L R  ++  L                PP +  SL ++  V++  +  
Sbjct: 397  YNTRHGPSNTLYHLVRDVKKGNL----------------PPDYRISLIDIGLVIEYLMGG 440

Query: 477  ACRGFYQDGRPGDRRRAEKGPAKRPTGQKWL-----------------------LDLNQK 513
            A R  Y   R         GP KRP   K L                       +DL+  
Sbjct: 441  AYRCNYTRKRFRTLYHNLFGP-KRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDP 499

Query: 514  SEN----PWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAAR 569
              N    P+ +L +WAVL  R +MA +FW  G+E +A AL ACK+ K M+H  +E +   
Sbjct: 500  EINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVD 559

Query: 570  ATREA------KYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAF 623
               +        + +LA++L  + Y   E  A  LL    + WS  TCL LA  A  + F
Sbjct: 560  DISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDF 619

Query: 624  FAHDGVQAFLTRIWWGD--MAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLED-- 679
             AH   Q  LT +W G   M   + +  +LG  L P+++        ++ P  +  ++  
Sbjct: 620  IAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKN-KDDMPYMSQAQEIH 678

Query: 680  LQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGP-----------RAVFLLTRWRKFW 728
            LQ+ ++ + EK      +  +E      R  G+              R + L  +  +F+
Sbjct: 679  LQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFY 738

Query: 729  GAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFF 788
             AP+  F    + Y  +L LF Y++LV      + PS  E  +  ++FTL +E++R+   
Sbjct: 739  NAPIVKFWFYTLAYIGYLMLFNYIVLVKME---RWPSTQEWIVISYIFTLGIEKMRE-IL 794

Query: 789  TDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTL 847
              E   L++K  +++ + WN  D++AI LF VG+  R+    F + GR +  ++ + + +
Sbjct: 795  MSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYI 854

Query: 848  RLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFR 907
            RL+ IF ++K LGP ++++ +MM D+ +F+  + V L+++GV  QA+L P++     + +
Sbjct: 855  RLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAK 914

Query: 908  RVLYRPYLQIFGQIPLDEIDE-ARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVT 966
             + Y PY  I+G++  D+ID     N +     +   P C +    W+V  ++  +LLV 
Sbjct: 915  NIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKT--GAWIVPAIMACYLLVA 972

Query: 967  NVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRR 1026
            N+LL+NLLIA+F+ TF  V+  ++  WKFQRY LI+ +HERP L PP I+ SH+++  + 
Sbjct: 973  NILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQH 1032

Query: 1027 VFKKEAEHKREHLERD------LPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRK 1080
            +  +  +H+ +  ERD      + D   +KV  +E    E +  + + R   S  E +R 
Sbjct: 1033 LCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRV 1092

Query: 1081 TAHRVDFIAKYLGGLREQEKRIK 1103
            T+ RV+ ++  L  + E+E  +K
Sbjct: 1093 TSERVENMSMRLEEVNEREHSMK 1115


>gi|18921093 transient receptor potential cation channel, subfamily M,
            member 6 [Homo sapiens]
          Length = 2022

 Score =  427 bits (1099), Expect = e-119
 Identities = 336/1164 (28%), Positives = 556/1164 (47%), Gaps = 103/1164 (8%)

Query: 26   GEVNF-GGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWL 84
            G +NF  G      K++R         L  L+L EW +  P LV+S+ G  Q F M S  
Sbjct: 96   GTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKF 155

Query: 85   RDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGR 144
            +++  +GLVKAA++TGAWI+T  +  G+++HVG A++ HS  S     ++  VG+   G 
Sbjct: 156  KEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKSHSSHSLR---KIWTVGIPPWGV 212

Query: 145  VLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRL 204
            + ++R L    +D    Y   D      L +L+S  SHFIL + G  GK     +LR  L
Sbjct: 213  IENQRDL--IGKDVVCLYQTLDN-PLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNL 269

Query: 205  EKHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGIADVLA 264
            EK++S Q+        +  PV+ L+V G PN +  +   V+   P ++  G+G  AD+LA
Sbjct: 270  EKYLSLQKIHCRSRQGV--PVVGLVVEGGPNVILSVWETVKDKDPVVVCEGTGRAADLLA 327

Query: 265  ALVNQPHLLVPKVAEKQFKEKF-----PSKHFSWEDIVRWTKLLQNITSHQHLLTVYDFE 319
                  HL    +   Q KE+       + +FS +      ++L     H+  +T++D +
Sbjct: 328  --FTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQILMECMVHRDCITIFDAD 385

Query: 320  QEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCD 379
             E  ++LD  IL AL+K     + E      +L LA+AWDRVDIAK  I   +  WK   
Sbjct: 386  SEEQQDLDLAILTALLKGTNLSASE------QLNLAMAWDRVDIAKKHILIYEQHWKPDA 439

Query: 380  LEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVS--RKSLLFDLLQRKQE 437
            LE+ M DALV ++ +FV+L ++ G ++  FLT  RL+ELY +      +LL  L+Q  ++
Sbjct: 440  LEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQ 499

Query: 438  EA-----RLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGF-YQDGRPGDRR 491
                   R+TL  +G     E   G  A+  +   +  +    +  R + +Q    G+R 
Sbjct: 500  HTLLSGYRITLIDIGL--VVEYLIGR-AYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRN 556

Query: 492  RAEKG-----------PAKRPTGQKWLLDLNQKSEN--------------PWRDLFLWAV 526
             + +            P K       L    +KS+               P+ DL +WAV
Sbjct: 557  ESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAV 616

Query: 527  LQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAAR-ATREAK-----YERLA 580
            L  R +MA +FW  G+E    A+ AC + + M+H   E+     A+ E K     + +LA
Sbjct: 617  LMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLA 676

Query: 581  LDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGD 640
            LDL  + +  +E  A  LL    R WS +TCL LA     + F +H   Q  LT +W G 
Sbjct: 677  LDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGR 736

Query: 641  MAAG-TPILRLLGAFLCPALVYT---------NLITFSEEAPLRTGLEDLQDLDSLDTEK 690
            +       L+++ + + P  + T         + +  S++        D     S ++  
Sbjct: 737  LKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESAS 796

Query: 691  SPLYGLQSRVEELVEAPRAQG-DRGPRAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLF 749
               Y L+   +E ++  +  G + G + +    +  +F+ AP+  F    + Y AFL LF
Sbjct: 797  VKEYDLERGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLF 856

Query: 750  TYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNK 809
            TY +LV+ +P P   S  E  +  ++FT  +E +R+     E     +K  +++ + WN 
Sbjct: 857  TYTVLVEMQPQP---SVQEWLVSIYIFTNAIEVVRE-ICISEPGKFTQKVKVWISEYWNL 912

Query: 810  CDMVAIFLFIVGVTCRMLPSAFE-AGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVER 868
             + VAI LF  G   R     F  AGR +  +D + +  RL+  FA+++  GP + ++ +
Sbjct: 913  TETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAK 972

Query: 869  MMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDE 928
            M  ++F+ +  +++ L+++GV  +A+L P +     + R +++ PY  I+G++   EID 
Sbjct: 973  MTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDV 1032

Query: 929  ARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGN 988
                CS+ P       SCP    ++L   L   +L V  ++++NLLIA F+  +  ++  
Sbjct: 1033 ----CSSQP-------SCPP--GSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESI 1079

Query: 989  ADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERDLPDPLD 1048
            ++  WK+ RY  I+ YHE+P L PP ILLSH+ L LRR+    A H +E  +  L   L 
Sbjct: 1080 SNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAPHDQEEGDVGLKLYLS 1139

Query: 1049 QKVVT-----WETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKRIK 1103
            ++ +       E   ++ F  KME      E E +R T+ RV  +   L  + E+   IK
Sbjct: 1140 KEDLKKLHDFEEQCVEKYFHEKMEDVNCSCE-ERIRVTSERVTEMYFQLKEMNEKVSFIK 1198

Query: 1104 ----CLESQINYCSVLVSSVADVL 1123
                 L+SQ+ +   L +   D L
Sbjct: 1199 DSLLSLDSQVGHLQDLSALTVDTL 1222


>gi|148612863 transient receptor potential cation channel, subfamily
            M, member 7 [Homo sapiens]
          Length = 1865

 Score =  418 bits (1074), Expect = e-116
 Identities = 333/1192 (27%), Positives = 562/1192 (47%), Gaps = 132/1192 (11%)

Query: 26   GEVNF-GGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWL 84
            G +NF GGS   R K+VR+     P V+  LLL EW +  P LV+S+ G  Q F +   +
Sbjct: 93   GVINFQGGSHSYRAKYVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRI 152

Query: 85   RDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGR 144
            + +L KGL+KAA +TGAWILT  +  G+A+HVG A+++H  AS S++ ++  +G+A  G 
Sbjct: 153  KQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEH--ASRSSR-KICTIGIAPWGV 209

Query: 145  VLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLD--SNL-SHFILVEPGPPGKGDGLTELR 201
            + +R  L     D    Y         PL  L+  +NL SHFILV+ G  GK      LR
Sbjct: 210  IENRNDL--VGRDVVAPYQT----LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLR 263

Query: 202  LRLEKHISEQRAGYG-GTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGG 258
              LEK I++QR     G G   +PV+ L+  G PN +  +   ++++ P  ++V  G+G 
Sbjct: 264  RELEKTINQQRIHARIGQG---VPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGR 320

Query: 259  IADVLAALVNQPHL--LVPKVAEKQFKEKFPSK-HFSWEDIVRWTKLLQNITSHQHLLTV 315
             AD+LA +  Q      +P  AE           +F   + +   + L      + L+TV
Sbjct: 321  AADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEALHLFQTLMECMKRKELITV 380

Query: 316  YDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEW 375
            +    +  +++D  IL AL+K   + +       D+L L +AWDRVDIAK+ +F    +W
Sbjct: 381  FHIGSDEHQDIDVAILTALLKGTNASA------FDQLILTLAWDRVDIAKNHVFVYGQQW 434

Query: 376  KSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKS--LLFDLLQ 433
                LE+ M+DALV ++  FV+L ++NG  +  FLT  RL+ELY +    +  +LF L++
Sbjct: 435  LVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVR 494

Query: 434  RKQE---------------------------------EARLTLAGLGTQQARE----PPA 456
              ++                                   RL    LG    R       +
Sbjct: 495  DVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSS 554

Query: 457  GPPAFSLHEVSRVLKDFLQDACRGFY----QDGRPGDRRRAEKGPAKRPTGQKWLLDLNQ 512
             P     HE      D  +      +    Q  RP      E+G  KR   +  ++D++ 
Sbjct: 555  TPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDE--IVDIDD 612

Query: 513  KSEN----PWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAA 568
                    P  +L +WA L  R  MA + W  G+E +A AL ACKI + M++   +++  
Sbjct: 613  PETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLV 672

Query: 569  RATREA------KYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKA 622
              T E        + +LA++L  + +   E  A  LL    + WS +TCL LA  +  + 
Sbjct: 673  DDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRP 732

Query: 623  FFAHDGVQAFLTRIWWG--DMAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLEDL 680
            F AH   Q  L+ +W G  +M   +    +L   + PA++     T +E + +    +D 
Sbjct: 733  FVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQS-QDA 791

Query: 681  QDLDSLDTEKSPLYGLQSRVEELV-----EAPRAQGDRGPRAVFLLTRWRK--------- 726
              +   D+E +     Q+  EE+      E      + G   + +  + +K         
Sbjct: 792  HQMTMDDSENN----FQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYA 847

Query: 727  FWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQG 786
            F+ AP+  F  N + Y  FL L+T+V+LV      Q PS  E  +  ++FT  +E++R+ 
Sbjct: 848  FYHAPIVKFWFNTLAYLGFLMLYTFVVLVQME---QLPSVQEWIVIAYIFTYAIEKVRE- 903

Query: 787  FFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPS----------AFEAGRT 836
             F  E   + +K  ++  D +N  D +AI  F +G   R               F AGR 
Sbjct: 904  IFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRL 963

Query: 837  VLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLH 896
            +  ++ + + +RL+   A+++Q GP ++++ +M+ ++F+ +  +++ L+++GV  +A+L+
Sbjct: 964  IYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILY 1023

Query: 897  PHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVI 956
            PH+     + + +++ PY  IFG++   EID    N S  P +             WL  
Sbjct: 1024 PHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVC-ANDSVIPQICGPG--------TWLTP 1074

Query: 957  LLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFIL 1016
             L   +L V  ++++NLLIA F+  +  V+  +++ WK+QRY+ I+ YHE+P L PP I+
Sbjct: 1075 FLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLII 1134

Query: 1017 LSHLSLTLRRVFKKEAEHKREHLERDLPDPLDQKVV-TWETVQKENFLSKMEKRRRDSEG 1075
            LSH+      + K+  + K     +      DQK +  +E    E + ++ + +      
Sbjct: 1135 LSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSE 1194

Query: 1076 EVLRKTAHRVDFIA---KYLGGLREQEKR-IKCLESQINYCSVLVSSVADVL 1123
            E +R T  RV+ +    K +G      KR ++ L+SQI +   L +   D L
Sbjct: 1195 ERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTL 1246


>gi|94538366 transient receptor potential cation channel, subfamily M,
            member 1 [Homo sapiens]
          Length = 1603

 Score =  316 bits (809), Expect = 9e-86
 Identities = 230/796 (28%), Positives = 393/796 (49%), Gaps = 84/796 (10%)

Query: 359  DRVDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQEL 418
            +  D  K E+ N    W +  LE+ M+DALV ++ +FV+L ++NG ++  FLT  RL+EL
Sbjct: 445  EETDPRKIELLN----WVNA-LEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEEL 499

Query: 419  YRSVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAF--SLHEVSRVLKDFLQD 476
            Y +         LL R  +++ L                PP +  SL ++  VL+  +  
Sbjct: 500  YNTRLGPPNTLHLLVRDVKKSNL----------------PPDYHISLIDIGLVLEYLMGG 543

Query: 477  ACR-------------GFYQDGRPG--------DRRRAEKGPAKRPTGQKWLLDLN---- 511
            A R               +   RP         D     KG  K+   ++  +D++    
Sbjct: 544  AYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDDP 603

Query: 512  --QKSENPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAAR 569
               + + P+ +L +WAVL  R +MA + W  G+E +A AL ACK+ K M+H  +E++   
Sbjct: 604  AVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAKALVACKLYKAMAHESSESDLVD 663

Query: 570  ATRE------AKYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAF 623
               +        + +LAL+L  + Y + E  A  LL    + WS +TCL LA  A  + F
Sbjct: 664  DISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRDF 723

Query: 624  FAHDGVQAFLTRIWWGD--MAAGTPILRLLGAFLCPALVYTNLITFSEEA-PLRTGLEDL 680
             AH   Q  LT +W G   M     +  ++G  L P +++    T+ + +       ED 
Sbjct: 724  IAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPPTILFLEFRTYDDFSYQTSKENEDG 783

Query: 681  QDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFLLTRWRKFWGAPVTVFLGNVV 740
            ++ +  +T+ +   G +   EE          +  R++ + T+  +F+ AP+  F    +
Sbjct: 784  KEKEEENTDANADAGSRKGDEE-------NEHKKQRSIPIGTKICEFYNAPIVKFWFYTI 836

Query: 741  MYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFT 800
             Y  +L LF YV+LV        PS  E  +  ++ +L LE+IR+     E   L +K  
Sbjct: 837  SYLGYLLLFNYVILVRM---DGWPSLQEWIVISYIVSLALEKIRE-ILMSEPGKLSQKIK 892

Query: 801  LYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTLRLIHIFAIHKQL 859
            +++ + WN  D+VAI  F++G   R+    +   GR +  +D + + +R++ IF ++K L
Sbjct: 893  VWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYL 952

Query: 860  GPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFG 919
            GP ++++ +MM D+ +F+  + V L+++GV  QA+LHP +     + R + Y PY  I+G
Sbjct: 953  GPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYG 1012

Query: 920  QIPLDEID----EARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLI 975
            ++  D+ID    E    C  +    E     P +   WL   L+  +LLV N+LL+NLLI
Sbjct: 1013 EVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLI 1072

Query: 976  AMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRV---FKKEA 1032
            A+F+ TF  V+  ++  WKFQRY LI+ +H+RP L PP I+LSH+ + + R+    +K+ 
Sbjct: 1073 AVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKR 1132

Query: 1033 EHKREHLERDL-----PDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDF 1087
            E  +E  +R L      + L +     E   +E+F  K E  ++ S  E +R T+ RV+ 
Sbjct: 1133 EGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREK-EDEQQSSSDERIRVTSERVEN 1191

Query: 1088 IAKYLGGLREQEKRIK 1103
            ++  L  + E+E  +K
Sbjct: 1192 MSMRLEEINERETFMK 1207



 Score =  153 bits (387), Expect = 8e-37
 Identities = 115/363 (31%), Positives = 182/363 (50%), Gaps = 45/363 (12%)

Query: 31  GGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRK 90
           GG    +  ++RV     P  L  L++ +W L  P L++S+ G  Q F M+  L+ V  K
Sbjct: 63  GGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGK 122

Query: 91  GLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRI 150
           GL+KAA +TGAWI T  +  G+  HVG A++DH   S+ ++ RV A+G+A  G V ++  
Sbjct: 123 GLIKAAMTTGAWIFTGGVSTGVISHVGDALKDH---SSKSRGRVCAIGIAPWGIVENKED 179

Query: 151 LEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISE 210
           L    +D    Y +        L  L+++ +HFIL + G  GK     +LR  LEKHIS 
Sbjct: 180 L--VGKDVTRVY-QTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISL 236

Query: 211 Q----RAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGGIADVLA 264
           Q    R G G      +P++ L+V G PN +  +   +++  P  +++  GSG  +D+L+
Sbjct: 237 QKINTRLGQG------VPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILS 290

Query: 265 ---------ALVNQ---PHLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHL 312
                     ++N+     LLV    +K F       H  +  I+   K        + L
Sbjct: 291 FAHKYCEEGGIINESLREQLLV--TIQKTFNYNKAQSHQLFAIIMECMK-------KKEL 341

Query: 313 LTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGD 372
           +TV+    EG ++++  IL AL+K     +       D+L LA+AW+RVDIA+S+IF   
Sbjct: 342 VTVFRMGSEGQQDIEMAILTALLKGTNVSAP------DQLSLALAWNRVDIARSQIFVFG 395

Query: 373 VEW 375
             W
Sbjct: 396 PHW 398


>gi|45935368 transient receptor potential cation channel, subfamily
           M, member 3 isoform h [Homo sapiens]
          Length = 230

 Score =  125 bits (314), Expect = 2e-28
 Identities = 84/235 (35%), Positives = 122/235 (51%), Gaps = 26/235 (11%)

Query: 40  FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99
           +VRV     P +L  L+  EW L  P L++S+ G  Q F ++  L+ V  KGL+KAA +T
Sbjct: 2   YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 100 GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158
           GAWI T  +  G+ RHVG A++DH   ++ ++ ++  +G+A  G V       E QED  
Sbjct: 62  GAWIFTGGVNTGVIRHVGDALKDH---ASKSRGKICTIGIAPWGIV-------ENQEDLI 111

Query: 159 ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQ---- 211
               V   +        L  L+S  SHFIL + G  GK     +LR +LEKHIS Q    
Sbjct: 112 GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171

Query: 212 RAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGGIADVLA 264
           R G G      +PV+ L+V G PN +  +   +    P  ++V  GSG  +D+LA
Sbjct: 172 RIGQG------VPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILA 220


>gi|55953096 transient receptor potential cation channel, subfamily
           M, member 3 isoform c [Homo sapiens]
          Length = 255

 Score =  120 bits (300), Expect = 1e-26
 Identities = 84/254 (33%), Positives = 124/254 (48%), Gaps = 39/254 (15%)

Query: 40  FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99
           +VRV     P +L  L+  EW L  P L++S+ G  Q F ++  L+ V  KGL+KAA +T
Sbjct: 2   YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 100 GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158
           GAWI T  +  G+ RHVG A++DH   ++ ++ ++  +G+A  G V       E QED  
Sbjct: 62  GAWIFTGGVNTGVIRHVGDALKDH---ASKSRGKICTIGIAPWGIV-------ENQEDLI 111

Query: 159 ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHIS------ 209
               V   +        L  L+S  SHFIL + G  GK     +LR +LEKHIS      
Sbjct: 112 GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171

Query: 210 --------EQRAGYGGTGSIE---------IPVLCLLVNGDPNTLERISRAVEQAAPWLI 252
                   + R  Y   GS +         +PV+ L+V G PN +  +   +    P  +
Sbjct: 172 RCLPFFSLDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPV 231

Query: 253 LV--GSGGIADVLA 264
           +V  GSG  +D+LA
Sbjct: 232 VVCDGSGRASDILA 245


>gi|6912736 transient receptor potential cation channel, subfamily C,
            member 5 [Homo sapiens]
          Length = 973

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 70/327 (21%), Positives = 133/327 (40%), Gaps = 65/327 (19%)

Query: 731  PVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQG 786
            P   F+ +   Y  FLF+      +++  D       P+  E  +  WV   +  EI++ 
Sbjct: 363  PFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEM 422

Query: 787  FFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAG------------ 834
            +           FT Y+ D WN  D     L++  ++ +++      G            
Sbjct: 423  WDGG--------FTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHP 474

Query: 835  ----RTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYG-- 888
                  + A+  ++ +LRLI +F  +  LGP  I + RM+ D+  FLF   + L+A+   
Sbjct: 475  TLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 534

Query: 889  -------VTTQALLHPH----------DGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARV 931
                     T+A+  P+          +     +F   L   +  +FG +          
Sbjct: 535  LNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLF-ETLQSLFWSVFGLLN--------- 584

Query: 932  NCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADM 991
                   L   +      +  ++   +  T+ +++ V+L+N+LIAM + ++Q++  +AD+
Sbjct: 585  -------LYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADI 637

Query: 992  FWKFQRYNLIVEY-HERPALAPPFILL 1017
             WKF R  L + Y  E   L PPF ++
Sbjct: 638  EWKFARTKLWMSYFDEGGTLPPPFNII 664


>gi|209863032 transient receptor potential cation channel, subfamily
            C, member 4 isoform zeta [Homo sapiens]
          Length = 804

 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 73/323 (22%), Positives = 125/323 (38%), Gaps = 66/323 (20%)

Query: 731  PVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQ- 785
            P   F+ +   Y  FLFL      ++   D       P+  E  +  WV   +  EI+Q 
Sbjct: 189  PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 248

Query: 786  --GFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLP----SAFE------- 832
              G   D           Y+ D WN  D V   L++  ++ +++     SA         
Sbjct: 249  WDGGLQD-----------YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 297

Query: 833  -----AGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAY 887
                     + A+  +  +LRLI +F  +  LGP  I + RM+ D+  FLF   + L+A+
Sbjct: 298  WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 357

Query: 888  ---------------GVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVN 932
                           G+T + +               L   +  IFG I L         
Sbjct: 358  ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL--------- 408

Query: 933  CSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMF 992
                      +      +  ++   +  T+ +++ V+L+N+LIAM + ++Q++  +AD+ 
Sbjct: 409  -------YVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIE 461

Query: 993  WKFQRYNLIVEYHERPALAP-PF 1014
            WKF R  L + Y E     P PF
Sbjct: 462  WKFARTKLWMSYFEEGGTLPTPF 484


>gi|209863030 transient receptor potential cation channel, subfamily
            C, member 4 isoform delta [Homo sapiens]
          Length = 836

 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 73/323 (22%), Positives = 125/323 (38%), Gaps = 66/323 (20%)

Query: 731  PVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQ- 785
            P   F+ +   Y  FLFL      ++   D       P+  E  +  WV   +  EI+Q 
Sbjct: 362  PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 421

Query: 786  --GFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLP----SAFE------- 832
              G   D           Y+ D WN  D V   L++  ++ +++     SA         
Sbjct: 422  WDGGLQD-----------YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470

Query: 833  -----AGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAY 887
                     + A+  +  +LRLI +F  +  LGP  I + RM+ D+  FLF   + L+A+
Sbjct: 471  WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530

Query: 888  ---------------GVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVN 932
                           G+T + +               L   +  IFG I L         
Sbjct: 531  ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL--------- 581

Query: 933  CSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMF 992
                      +      +  ++   +  T+ +++ V+L+N+LIAM + ++Q++  +AD+ 
Sbjct: 582  -------YVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIE 634

Query: 993  WKFQRYNLIVEYHERPALAP-PF 1014
            WKF R  L + Y E     P PF
Sbjct: 635  WKFARTKLWMSYFEEGGTLPTPF 657


>gi|209863026 transient receptor potential cation channel, subfamily
            C, member 4 isoform beta [Homo sapiens]
          Length = 893

 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 73/323 (22%), Positives = 125/323 (38%), Gaps = 66/323 (20%)

Query: 731  PVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQ- 785
            P   F+ +   Y  FLFL      ++   D       P+  E  +  WV   +  EI+Q 
Sbjct: 362  PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 421

Query: 786  --GFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLP----SAFE------- 832
              G   D           Y+ D WN  D V   L++  ++ +++     SA         
Sbjct: 422  WDGGLQD-----------YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470

Query: 833  -----AGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAY 887
                     + A+  +  +LRLI +F  +  LGP  I + RM+ D+  FLF   + L+A+
Sbjct: 471  WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530

Query: 888  ---------------GVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVN 932
                           G+T + +               L   +  IFG I L         
Sbjct: 531  ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL--------- 581

Query: 933  CSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMF 992
                      +      +  ++   +  T+ +++ V+L+N+LIAM + ++Q++  +AD+ 
Sbjct: 582  -------YVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIE 634

Query: 993  WKFQRYNLIVEYHERPALAP-PF 1014
            WKF R  L + Y E     P PF
Sbjct: 635  WKFARTKLWMSYFEEGGTLPTPF 657


>gi|209863024 transient receptor potential cation channel, subfamily
            C, member 4 isoform epsilon [Homo sapiens]
          Length = 982

 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 73/323 (22%), Positives = 125/323 (38%), Gaps = 66/323 (20%)

Query: 731  PVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQ- 785
            P   F+ +   Y  FLFL      ++   D       P+  E  +  WV   +  EI+Q 
Sbjct: 362  PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 421

Query: 786  --GFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLP----SAFE------- 832
              G   D           Y+ D WN  D V   L++  ++ +++     SA         
Sbjct: 422  WDGGLQD-----------YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470

Query: 833  -----AGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAY 887
                     + A+  +  +LRLI +F  +  LGP  I + RM+ D+  FLF   + L+A+
Sbjct: 471  WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530

Query: 888  ---------------GVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVN 932
                           G+T + +               L   +  IFG I L         
Sbjct: 531  ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL--------- 581

Query: 933  CSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMF 992
                      +      +  ++   +  T+ +++ V+L+N+LIAM + ++Q++  +AD+ 
Sbjct: 582  -------YVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIE 634

Query: 993  WKFQRYNLIVEYHERPALAP-PF 1014
            WKF R  L + Y E     P PF
Sbjct: 635  WKFARTKLWMSYFEEGGTLPTPF 657


>gi|7706747 transient receptor potential cation channel, subfamily C,
            member 4 isoform alpha [Homo sapiens]
          Length = 977

 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 73/323 (22%), Positives = 125/323 (38%), Gaps = 66/323 (20%)

Query: 731  PVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQ- 785
            P   F+ +   Y  FLFL      ++   D       P+  E  +  WV   +  EI+Q 
Sbjct: 362  PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 421

Query: 786  --GFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLP----SAFE------- 832
              G   D           Y+ D WN  D V   L++  ++ +++     SA         
Sbjct: 422  WDGGLQD-----------YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470

Query: 833  -----AGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAY 887
                     + A+  +  +LRLI +F  +  LGP  I + RM+ D+  FLF   + L+A+
Sbjct: 471  WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530

Query: 888  ---------------GVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVN 932
                           G+T + +               L   +  IFG I L         
Sbjct: 531  ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL--------- 581

Query: 933  CSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMF 992
                      +      +  ++   +  T+ +++ V+L+N+LIAM + ++Q++  +AD+ 
Sbjct: 582  -------YVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIE 634

Query: 993  WKFQRYNLIVEYHERPALAP-PF 1014
            WKF R  L + Y E     P PF
Sbjct: 635  WKFARTKLWMSYFEEGGTLPTPF 657


>gi|22547184 transient receptor potential cation channel, subfamily V,
            member 4 isoform a [Homo sapiens]
          Length = 871

 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 83/347 (23%), Positives = 146/347 (42%), Gaps = 31/347 (8%)

Query: 672  PLRTGLEDLQDLDSLDTEKSPLYGL--QSRVEELVEAPRAQGDRGPRAVFLLTRWRKFWG 729
            P+ + L DL  LD+   E S L  L   S++E   E    +    P    L  +WRKF  
Sbjct: 413  PVYSSLYDLSSLDTCGEEASVLEILVYNSKIENRHEMLAVE----PINELLRDKWRKFGA 468

Query: 730  APVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQ 785
                 F  NVV Y   + +FT    Y  L    P P   +   + L   V TL    +  
Sbjct: 469  VS---FYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLF- 524

Query: 786  GFFTDEDTHLVKKF----TLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAMD 841
             FFT+     +KK     +L++  ++    +  I+  +V V+  +  +  EA   V+   
Sbjct: 525  -FFTNIKDLFMKKCPGVNSLFIDGSFQL--LYFIYSVLVIVSAALYLAGIEAYLAVMVFA 581

Query: 842  FMVFTLRLIHIFAIHKQLGPKIIVVERMM-KDVFFFLFFLSVWLVAYGVTTQALLHPHDG 900
             ++  +  ++     K  G   I++++++ KD+F FL    ++++ Y     +LL+P   
Sbjct: 582  LVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCAN 641

Query: 901  ----RLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVI 956
                  +     V   P  +         +D  ++      L +  S   P ++     I
Sbjct: 642  MKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVF-----I 696

Query: 957  LLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVE 1003
            +LLVT++++T VLL+N+LIA+   T   V   +   WK Q    I++
Sbjct: 697  ILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILD 743


>gi|21735483 transient receptor potential cation channel, subfamily V,
            member 3 [Homo sapiens]
          Length = 790

 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 34/146 (23%), Positives = 71/146 (48%), Gaps = 19/146 (13%)

Query: 863  IIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLH--PHDGRLEWIFRRVLYRPYLQIFGQ 920
            +++ + ++ DV  FLF   V+L+ +GV   +L+   P D +                +G 
Sbjct: 577  VMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNK------------DCSSYGS 624

Query: 921  IPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSY 980
                 ++  ++      L ++ +   P L+     + LL+T++++T VLL+N+LIA+   
Sbjct: 625  FSDAVLELFKLTIGLGDLNIQQNSKYPILF-----LFLLITYVILTFVLLLNMLIALMGE 679

Query: 981  TFQVVQGNADMFWKFQRYNLIVEYHE 1006
            T + V   ++  W+ QR   I+E+ +
Sbjct: 680  TVENVSKESERIWRLQRARTILEFEK 705


>gi|22547180 transient receptor potential cation channel, subfamily V,
            member 4 isoform b [Homo sapiens]
          Length = 811

 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 69/297 (23%), Positives = 126/297 (42%), Gaps = 25/297 (8%)

Query: 720  LLTRWRKFWGAPVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWV 775
            L  +WRKF       F  NVV Y   + +FT    Y  L    P P   +   + L   V
Sbjct: 399  LRDKWRKFGAVS---FYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEV 455

Query: 776  FTLVLEEIRQGFFTDEDTHLVKKF----TLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAF 831
             TL    +   FFT+     +KK     +L++  ++    +  I+  +V V+  +  +  
Sbjct: 456  ITLFTGVLF--FFTNIKDLFMKKCPGVNSLFIDGSFQL--LYFIYSVLVIVSAALYLAGI 511

Query: 832  EAGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMM-KDVFFFLFFLSVWLVAYGVT 890
            EA   V+    ++  +  ++     K  G   I++++++ KD+F FL    ++++ Y   
Sbjct: 512  EAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASA 571

Query: 891  TQALLHPHDGRL----EWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSC 946
              +LL+P         +     V   P  +         +D  ++      L +  S   
Sbjct: 572  LVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKY 631

Query: 947  PSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVE 1003
            P ++     I+LLVT++++T VLL+N+LIA+   T   V   +   WK Q    I++
Sbjct: 632  PVVF-----IILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILD 683


>gi|5730102 transient receptor potential cation channel, subfamily C,
            member 6 [Homo sapiens]
          Length = 931

 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 45/172 (26%), Positives = 76/172 (44%), Gaps = 15/172 (8%)

Query: 848  RLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFR 907
            R+ +I   ++  GP  I + R +KD+F F+    +  VA+ +    L   + G  +    
Sbjct: 609  RIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAF 668

Query: 908  RVLYRPYLQIFGQI-PLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVT 966
              +   +  +F  I  L E+    +N + H  +         +Y   +VI+LL       
Sbjct: 669  TTVEESFKTLFWAIFGLSEVKSVVINYN-HKFIENIGYVLYGVYNVTMVIVLL------- 720

Query: 967  NVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAP-PFILL 1017
                 N+LIAM + +FQ ++ +AD+ WKF R  L   Y E     P PF L+
Sbjct: 721  -----NMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLV 767


>gi|209863028 transient receptor potential cation channel, subfamily
           C, member 4 isoform gamma [Homo sapiens]
          Length = 828

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 62/297 (20%), Positives = 111/297 (37%), Gaps = 65/297 (21%)

Query: 731 PVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQ- 785
           P   F+ +   Y  FLFL      ++   D       P+  E  +  WV   +  EI+Q 
Sbjct: 362 PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 421

Query: 786 --GFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLP----SAFE------- 832
             G   D           Y+ D WN  D V   L++  ++ +++     SA         
Sbjct: 422 WDGGLQD-----------YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470

Query: 833 -----AGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAY 887
                    + A+  +  +LRLI +F  +  LGP  I + RM+ D+  FLF   + L+A+
Sbjct: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530

Query: 888 ---------------GVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVN 932
                          G+T + +               L   +  IFG I           
Sbjct: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLIN---------- 580

Query: 933 CSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNA 989
                 L   +      +  ++   +  T+ +++ V+L+N+LIAM + ++Q++   A
Sbjct: 581 ------LYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRA 631


>gi|9966865 transient receptor potential cation channel, subfamily C,
            member 7 [Homo sapiens]
          Length = 862

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 51/211 (24%), Positives = 91/211 (43%), Gaps = 35/211 (16%)

Query: 848  RLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVA--------YGVTTQALLHPHD 899
            R+ +I   ++  GP  I + R +KD+F F+    +  VA        Y     A  +P  
Sbjct: 554  RIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAF 613

Query: 900  GRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLL 959
              +E  F+ + +     IFG   L E+           +L  D       +   +  +L 
Sbjct: 614  TTVEESFKTLFW----SIFG---LSEVISV--------VLKYDHK-----FIENIGYVLY 653

Query: 960  VTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAP-PFILLS 1018
              + +   V+L+N+LIAM + ++Q ++ +AD+ WKF R  L + Y +     P PF L+ 
Sbjct: 654  GVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVP 713

Query: 1019 ------HLSLTLRRVFKKEAEHKREHLERDL 1043
                  +L + ++    K  + K +  E DL
Sbjct: 714  SPKSFYYLIMRIKMCLIKLCKSKAKSCENDL 744


>gi|194733735 transient receptor potential cation channel, subfamily
            C, member 3 isoform a [Homo sapiens]
          Length = 921

 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 45/180 (25%), Positives = 84/180 (46%), Gaps = 31/180 (17%)

Query: 848  RLIHIFAIHKQLGPKIIVVERMMKDVF---------FFLFFLSVWLVAYGVTTQALLHPH 898
            R+ +I   ++  GP  I + R +KD+F         FF F + ++++ Y     A ++  
Sbjct: 625  RIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFIL-YSYYLGAKVNAA 683

Query: 899  DGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILL 958
               +E  F+ + +     IFG   L E+        T  +L  D       +   +  +L
Sbjct: 684  FTTVEESFKTLFW----SIFG---LSEV--------TSVVLKYDHK-----FIENIGYVL 723

Query: 959  LVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEY-HERPALAPPFILL 1017
               + +   V+L+N+LIAM + ++Q ++ ++D+ WKF R  L + Y  +   L PPF L+
Sbjct: 724  YGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLV 783


>gi|4507687 transient receptor potential cation channel, subfamily C,
            member 3 isoform b [Homo sapiens]
          Length = 848

 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 45/180 (25%), Positives = 84/180 (46%), Gaps = 31/180 (17%)

Query: 848  RLIHIFAIHKQLGPKIIVVERMMKDVF---------FFLFFLSVWLVAYGVTTQALLHPH 898
            R+ +I   ++  GP  I + R +KD+F         FF F + ++++ Y     A ++  
Sbjct: 552  RIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFIL-YSYYLGAKVNAA 610

Query: 899  DGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILL 958
               +E  F+ + +     IFG   L E+        T  +L  D       +   +  +L
Sbjct: 611  FTTVEESFKTLFW----SIFG---LSEV--------TSVVLKYDHK-----FIENIGYVL 650

Query: 959  LVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEY-HERPALAPPFILL 1017
               + +   V+L+N+LIAM + ++Q ++ ++D+ WKF R  L + Y  +   L PPF L+
Sbjct: 651  YGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLV 710


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,446,059
Number of Sequences: 37866
Number of extensions: 2278683
Number of successful extensions: 5959
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 5731
Number of HSP's gapped (non-prelim): 111
length of query: 1165
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1052
effective length of database: 13,968,660
effective search space: 14695030320
effective search space used: 14695030320
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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