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Search of human proteins with 111955084
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]
(1080 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens] 2094 0.0
gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens] 1997 0.0
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 150 5e-36
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 150 5e-36
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 150 5e-36
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 150 5e-36
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 150 5e-36
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 150 5e-36
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 150 5e-36
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 150 5e-36
gi|148746195 trichohyalin [Homo sapiens] 150 8e-36
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 117 8e-26
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 117 8e-26
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 117 8e-26
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 117 8e-26
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 114 5e-25
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 111 4e-24
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 108 3e-23
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 108 4e-23
gi|21735548 centrosomal protein 2 [Homo sapiens] 107 5e-23
gi|16262452 cingulin [Homo sapiens] 107 5e-23
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 107 6e-23
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 106 1e-22
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 106 1e-22
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 106 1e-22
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 106 1e-22
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 105 2e-22
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 105 2e-22
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 105 2e-22
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 105 2e-22
>gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]
Length = 1080
Score = 2094 bits (5425), Expect = 0.0
Identities = 1080/1080 (100%), Positives = 1080/1080 (100%)
Query: 1 MKGTRAIGSVPERSPAGVDLSLTGLPPPVSRRPGSAATTKPIVRSVSVVTGSEQKRKVLE 60
MKGTRAIGSVPERSPAGVDLSLTGLPPPVSRRPGSAATTKPIVRSVSVVTGSEQKRKVLE
Sbjct: 1 MKGTRAIGSVPERSPAGVDLSLTGLPPPVSRRPGSAATTKPIVRSVSVVTGSEQKRKVLE 60
Query: 61 ATGPGGSQAINNLRRSNSTTQVSQPRSGSPRPTEPTDFLMLFEGSPSGKKRPASLSTAPS 120
ATGPGGSQAINNLRRSNSTTQVSQPRSGSPRPTEPTDFLMLFEGSPSGKKRPASLSTAPS
Sbjct: 61 ATGPGGSQAINNLRRSNSTTQVSQPRSGSPRPTEPTDFLMLFEGSPSGKKRPASLSTAPS 120
Query: 121 EKGATWNVLDDQPRGFTLPSNARSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAVGN 180
EKGATWNVLDDQPRGFTLPSNARSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAVGN
Sbjct: 121 EKGATWNVLDDQPRGFTLPSNARSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAVGN 180
Query: 181 CVTTMVHNRYTPSERAPPLKSSNQTAPSLNNIIKAATCEGSESSGFGKLPKNVSSATHSA 240
CVTTMVHNRYTPSERAPPLKSSNQTAPSLNNIIKAATCEGSESSGFGKLPKNVSSATHSA
Sbjct: 181 CVTTMVHNRYTPSERAPPLKSSNQTAPSLNNIIKAATCEGSESSGFGKLPKNVSSATHSA 240
Query: 241 RNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAK 300
RNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAK
Sbjct: 241 RNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAK 300
Query: 301 REEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERG 360
REEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERG
Sbjct: 301 REEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERG 360
Query: 361 PPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEP 420
PPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEP
Sbjct: 361 PPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEP 420
Query: 421 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTH 480
QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTH
Sbjct: 421 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTH 480
Query: 481 HRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSG 540
HRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSG
Sbjct: 481 HRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSG 540
Query: 541 QDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTAR 600
QDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTAR
Sbjct: 541 QDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTAR 600
Query: 601 RVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCT 660
RVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCT
Sbjct: 601 RVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCT 660
Query: 661 ERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK 720
ERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK
Sbjct: 661 ERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK 720
Query: 721 QEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLE 780
QEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLE
Sbjct: 721 QEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLE 780
Query: 781 QEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKG 840
QEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKG
Sbjct: 781 QEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKG 840
Query: 841 REEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELV 900
REEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELV
Sbjct: 841 REEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELV 900
Query: 901 IHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEG 960
IHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEG
Sbjct: 901 IHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEG 960
Query: 961 ENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELA 1020
ENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELA
Sbjct: 961 ENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELA 1020
Query: 1021 TLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1080
TLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK
Sbjct: 1021 TLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1080
>gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens]
Length = 1044
Score = 1997 bits (5173), Expect = 0.0
Identities = 1040/1080 (96%), Positives = 1041/1080 (96%), Gaps = 36/1080 (3%)
Query: 1 MKGTRAIGSVPERSPAGVDLSLTGLPPPVSRRPGSAATTKPIVRSVSVVTGSEQKRKVLE 60
MKGTRAIGSVPERSPAGVDLSLTGLPPPVSRRPGSAATTKPIVRSVSVVTGSEQKRKVLE
Sbjct: 1 MKGTRAIGSVPERSPAGVDLSLTGLPPPVSRRPGSAATTKPIVRSVSVVTGSEQKRKVLE 60
Query: 61 ATGPGGSQAINNLRRSNSTTQVSQPRSGSPRPTEPTDFLMLFEGSPSGKKRPASLSTAPS 120
ATGPGGSQAINNLRRSNSTTQVSQPRSGSPRPTEPTDFLMLFEGSPSGKKRPASLSTAPS
Sbjct: 61 ATGPGGSQAINNLRRSNSTTQVSQPRSGSPRPTEPTDFLMLFEGSPSGKKRPASLSTAPS 120
Query: 121 EKGATWNVLDDQPRGFTLPSNARSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAVGN 180
EKGATWNVLDDQPRGFTLPSNARSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAVGN
Sbjct: 121 EKGATWNVLDDQPRGFTLPSNARSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAVGN 180
Query: 181 CVTTMVHNRYTPSERAPPLKSSNQTAPSLNNIIKAATCEGSESSGFGKLPKNVSSATHSA 240
CVTTMVHNRYTPSERAPPLKSSNQTAPSLNNIIKAATCEGSESSGFGKLPKNVSSATHSA
Sbjct: 181 CVTTMVHNRYTPSERAPPLKSSNQTAPSLNNIIKAATCEGSESSGFGKLPKNVSSATHSA 240
Query: 241 RNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAK 300
RNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAK
Sbjct: 241 RNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAK 300
Query: 301 REEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERG 360
REEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERG
Sbjct: 301 REEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERG 360
Query: 361 PPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEP 420
PPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEP
Sbjct: 361 PPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEP 420
Query: 421 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTH 480
QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTH
Sbjct: 421 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTH 480
Query: 481 HRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSG 540
HRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSG
Sbjct: 481 HRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSG 540
Query: 541 QDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTAR 600
QDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTAR
Sbjct: 541 QDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTAR 600
Query: 601 RVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCT 660
RVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCT
Sbjct: 601 RVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCT 660
Query: 661 ERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK 720
ERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK
Sbjct: 661 ERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK 720
Query: 721 QEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLE 780
QEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQR + LE
Sbjct: 721 QEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELE 780
Query: 781 QEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKG 840
ELRQQLEESSSALTRALRAEFEKG
Sbjct: 781 ------------------------------------ELRQQLEESSSALTRALRAEFEKG 804
Query: 841 REEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELV 900
REEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELV
Sbjct: 805 REEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELV 864
Query: 901 IHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEG 960
IHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEG
Sbjct: 865 IHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEG 924
Query: 961 ENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELA 1020
ENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELA
Sbjct: 925 ENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELA 984
Query: 1021 TLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1080
TLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK
Sbjct: 985 TLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1044
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 150 bits (380), Expect = 5e-36
Identities = 209/886 (23%), Positives = 356/886 (40%), Gaps = 131/886 (14%)
Query: 280 RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA 339
R ++ A + L +A + + Q E L Q+E RR+ A+Q +R+
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 340 IQELQQKRA-------LRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL 392
+ELQQ R +A++A AER E RV ++ A E QAL
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Query: 393 KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK 452
+A R + Q+ E + V + E+ SR A+
Sbjct: 1479 RA--------------RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524
Query: 453 SRGPLE-----ELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGK 507
+ E + L L+L +E + R R R + E S A E K
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA---ELQSK 1581
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
++F E + + ++ +E E+ Q Q ++++ E LE +
Sbjct: 1582 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER---AREEAERELERWQLKA 1638
Query: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA----------LSRQLQRQR 617
+RL+L+ EE Q L Q +Q++ R + KA ++L++QR
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 618 EHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKL 677
+ E T Q+ LA +LI + A + +Q+ Q E +A+ Q + +K
Sbjct: 1699 QLAEGTAQQRLAAEQELI--------RLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750
Query: 678 KELMSATEKARREKWI--------SEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSL 729
+EL + K R E + E+++ E + + LE E + +E RL++L
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARLRAL 1809
Query: 730 HEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQ 789
E E + + A + RQ E L + A+G+ R + +E+ A ++
Sbjct: 1810 AE-EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL---KEKEAENER 1865
Query: 790 RQRLYSEVAEERERLGQQAARQRAELEELRQQLEESS-SALTR----------------- 831
+RL + A +R RL +QAA+ +A++EE QL ++S S L R
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 832 ---ALRAEFEK---GREEQERRHQMELNTLKQQLE-----LERQAWEAGRTRKEEAWLLN 880
AL+A FEK G+ E E +EL ++ E E+ EA R R+ A
Sbjct: 1926 EILALKASFEKAAAGKAELE----LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981
Query: 881 REQELREEIRKGRDKEIELV---------IHRLEADMALAKEESEKAA-----------E 920
R +E E ++K E E + RL+A + A+ E+A E
Sbjct: 1982 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2041
Query: 921 SRIKRLRDKYEAELSELEQSERKLQERCSELKGQL----GEAEG--------ENLRLQGL 968
+ KRL+ + +A ++Q E++LQ+ + + L GEAE E R+Q
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2101
Query: 969 --VRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ 1026
Q R +E+A+ + + + AQ + R A +E R+A+AE A L+ +Q
Sbjct: 2102 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ 2161
Query: 1027 QLELE-EVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1071
+ E E H++ R++ V T ++ DH + LL++
Sbjct: 2162 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Score = 135 bits (339), Expect = 3e-31
Identities = 238/962 (24%), Positives = 398/962 (41%), Gaps = 146/962 (15%)
Query: 245 GGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQ 304
GG+ G + EEAE Q + ++R + + QR+ L ++A+ E
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528
Query: 305 RQRSGE-GTLLDLHQQKEAARRKARE---EKARQ-------ARRAAIQELQQKRALRAQK 353
R++ L +L Q E A R+ R+ E+ARQ A+R+A ELQ KRA A+K
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588
Query: 354 ASTAERGPPE---------NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAA 404
+ ER E E R + + LKAN A
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 405 GPGDRCLPTSDSSPEPQQPPEDR---------TQDVLAQDAAGDNLEMMAP-SRGSAKSR 454
+ + + E Q+ +R Q V ++ A LE + G+A+ R
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 455 GPLEELLHTL-----------QLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLE 503
E+ L L QLLE+E R A ++ + L E
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAELAKVRAE 1763
Query: 504 KFGKLSAFPEPPEDGTLLSEAKLQSIMS----FLDEMEKSGQ-----DQLDSQQEGWVPE 554
L++ E+ SE Q + + F + E++ + ++ Q++ +
Sbjct: 1764 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1823
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
A E ++ + + K +A + L+ A+ L RR+ E E R+L+
Sbjct: 1824 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLE 1881
Query: 615 RQREHYEATIQRHLAFI----DQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQ 667
Q ++A I+ LA + D +E +K L E ++++E + E+ A +
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Query: 668 AQHELEIKKLK----ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
A+ ELE+ +++ + + + E+A E + +E R E +QK +A ++
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 724 RRLK-SLHEAELLQSD--------ERASQRCLRQ------AEELREQLEREKEALGQQER 768
R+ K +L E E L++ ERA Q RQ A + R Q E + A Q++
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 769 ERARQRFQQHLEQEQWALQQQR-----QRLYSEVAEE----RERLGQQAARQRAELEELR 819
E Q QQ L+QEQ L Q R R +E AEE ER Q+ RQ E E L+
Sbjct: 2062 E---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2118
Query: 820 QQLEESSSALTRALRAEFEKGREEQE----RRHQMELNTLKQQ----LELERQAWEAGRT 871
Q EE + A +A +A EK R+E E RR Q E L+Q+ E+E+ A +T
Sbjct: 2119 QSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177
Query: 872 RKEEAWLLNREQELREEIRKGRDKE--IELVIHRLEADMALAKEESEKAAE--------- 920
+++A + LR ++ + ++ ++ + RL+A+ A + + E
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2237
Query: 921 SRIKRLRDKYEAE-----LSELEQSERKLQERCSELK------GQLGEAEGENLRLQGLV 969
+ +L+ + EAE L + + ++R LQE ++K +L A E RL+ L
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 970 RQ---KERAL------EDAQAVNE--QLSSERSNLAQ--VIRQEFEDRLAASEEETRQAK 1016
+ ++RAL E QAV E +L +E L Q + QE RL +E+ Q
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 1017 AE-----LATLQA--RQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELL 1069
AE TL+A ++QLE+ R+K +A A + + K+A+ + E L
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 1070 EQ 1071
+
Sbjct: 2418 HR 2419
Score = 129 bits (325), Expect = 1e-29
Identities = 220/871 (25%), Positives = 371/871 (42%), Gaps = 121/871 (13%)
Query: 252 RRKEVTEEEAERFIHQVNQATV--TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
+ K+ E EA RF +A + + Q Q AAR + E+ G
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843
Query: 310 EGTLLDLH-----QQKEAARRKAR---EEKARQARRAAIQELQQK-----RALRAQKAST 356
E T L ++KEA + R E++A Q RR Q Q K R + +KAS
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 357 AERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS 416
+E + E + RQ +E+ ALKA+ AAG + L
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEIL---------ALKASFEKA---AAGKAELELELGRI 1951
Query: 417 SPEPQQPPEDRTQDVLA-----QDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q L Q AA + KS EE + +E
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ L + + R +E++ A L +L A + E +LQ +
Sbjct: 2012 ERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL- 2069
Query: 532 FLDEMEKSGQDQLDSQQEGW---VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ 588
+ E+S DQL + E EA ++ E + S +++ E E KQ+
Sbjct: 2070 ---QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2125
Query: 589 RALAQQRDLTARRVKETEKALSRQLQ------RQREHYEATIQRHLAFIDQLIEDKKVLS 642
+A AQ + + KE E+ +R+ Q RQ++ +A +++H F +Q + K +
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 643 EKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKE 702
++ + +L++ D + + + E+++LK ATE AR+ + E+
Sbjct: 2186 QELTTLRLQLEETDHQ--------KNLLDEELQRLKA--EATEAARQRSQVEEEL----- 2230
Query: 703 VTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEA 762
+VR E+ KL AR + E R L + D+ +QR L++ E +Q+ E
Sbjct: 2231 FSVRVQMEELSKLKARIEAENRAL--------ILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 763 LGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQL 822
L +E AR R L +E A Q++ L ++ +E+ + Q+A R +AE E L+QQ
Sbjct: 2283 LSVAAQEAARLR---QLAEEDLA---QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336
Query: 823 EESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQ-----AWEAGRTRKEEAW 877
E + R ++ +E+ ++ E ++ LE ERQ + EA R + A
Sbjct: 2337 ELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2391
Query: 878 LLNREQELREEIRKGRDK--EIELVIHRLEADMALAKEESEKAAES-RIKRLRDKYEAE- 933
+ + E+ ++ R + EI +HR E LA +E ++ I+R + ++AE
Sbjct: 2392 MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAER 2447
Query: 934 ----LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSE 989
++ELE+ + KLQ+ L QL E + + Q+E+ L++ QA+ + SE
Sbjct: 2448 LREAIAELEREKEKLQQEAKLL--QLKSEEMQTV-------QQEQLLQETQALQQSFLSE 2498
Query: 990 RSNLAQVIRQEFEDRLAASEEETRQ---AKAE-LATLQARQQLELEEVHRRVKTALARKE 1045
+ +L Q R+ F ++ A E+ Q AKA+ L Q RQQ ++E+ +R+ +A E
Sbjct: 2499 KDSLLQ--RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASME 2553
Query: 1046 EAVSSLRTQHEA--AVKRADHLEELLEQHRR 1074
EA R QHEA V+R + LEQ RR
Sbjct: 2554 EA---RRRQHEAEEGVRRKQEELQQLEQQRR 2581
Score = 108 bits (269), Expect = 4e-23
Identities = 194/856 (22%), Positives = 346/856 (40%), Gaps = 105/856 (12%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG 287
++ K++++ +AR + R K EE A R + Q + + + Q+R
Sbjct: 1989 RVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERAEQESARQLQLAQEAAQKRL 2047
Query: 288 AGAARLEHLLQAKREEQRQRS--GEGTLLD-LHQQKEAARRKARE-EKAR-QARRAAIQE 342
+ ++E++ Q++ E ++LD L + EAARR A E E+AR QA R A Q
Sbjct: 2048 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107
Query: 343 LQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLP 402
+Q K S E+ + +R+ A++ + AL+
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA----- 2162
Query: 403 AAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLH 462
+D+ E + ++T AQ + R LEE H
Sbjct: 2163 -----------ADAEMEKHKKFAEQTLRQKAQ-----------VEQELTTLRLQLEETDH 2200
Query: 463 TLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS 522
LL++E L T + + EE + + +E+ KL A E +L
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV---QMEELSKLKARIEAENRALILR 2257
Query: 523 EAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQ 582
+ D ++ Q++ + ++ V+ RL + +E +
Sbjct: 2258 DK---------DNTQRFLQEEAEKMKQ----------------VAEEAARLSVAAQEAAR 2292
Query: 583 AMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFID--QLIEDKKV 640
L + LAQQR L + +KE +A+ + + E Q+ LA +L EDK+
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 641 LSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKI 700
++++ +AE Q QR E Q Q + E ++LK + E +R + E ++
Sbjct: 2353 MAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLK--LRVAEMSRAQARAEEDAQRF 2406
Query: 701 KEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELRE---QLE 757
++ E +KL H+ E L + + L+Q+ E Q+ AE LRE +LE
Sbjct: 2407 RKQA----EEIGEKL---HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 758 REKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEE 817
REKE L QQE + + + ++ +Q L Q+ Q L E++ L Q+ E +
Sbjct: 2457 REKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2515
Query: 818 LRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAW 877
L +QL + A + LR E ++ +++ E+ Q + ++++ + +A E R ++EE
Sbjct: 2516 L-EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 878 LLNREQELREEIRKGRDKEIELVIHRLEAD--MALAKEE----SEKAAESRIKRLRDKYE 931
L +++ +EE+ ++ + + LE ALA E S+ AA + RD +
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2634
Query: 932 AELSELEQS------ERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQ 985
+E E RK+ + + G L E + L QG E L + V
Sbjct: 2635 GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL-AQGHTTVDE--LARREDVRHY 2691
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAE-----LATLQARQQLELEEVHRRVKTA 1040
L RS++A ++ + ++L+ RQ + L QA L+ V R T
Sbjct: 2692 LQG-RSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTV 2750
Query: 1041 LARKEEAVSSLRTQHE 1056
+E V H+
Sbjct: 2751 NEAVKEGVVGPELHHK 2766
Score = 95.1 bits (235), Expect = 3e-19
Identities = 174/693 (25%), Positives = 293/693 (42%), Gaps = 109/693 (15%)
Query: 418 PEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRP 477
P ++P + Q + Q A +E + +G A+ E++L P+ P
Sbjct: 1010 PLDKEPARECAQRIAEQQKAQAEVEGLG--KGVARLSAEAEKVLAL-------PEPSPAA 1060
Query: 478 RTHHRGRYAWASEEDDASSLTADNLEKFGKLSAF---PEPPEDGTLLSEAKL---QSIMS 531
T + + SL+A LEK +S + E+ E +L Q++ +
Sbjct: 1061 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1120
Query: 532 FLDEME--KSGQDQLDSQQEGWVPEAGP------GPLELGSEVSTSVMRLKLEVEE-KKQ 582
L E+E K+ +L +Q E P G E+G + +EVE +++
Sbjct: 1121 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1180
Query: 583 AMLLLQR--ALAQQRDLTARRVKETEKALSRQLQRQREHYE---ATIQRHLAFIDQL--- 634
LL+R A+ Q D+ R +++ L RQL+ RE + A +Q +Q+
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQ----LGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236
Query: 635 -IEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLK--ELMSATEKARREK 691
+ D + + E+ A L +E +R E+V + Q + I +K EL T KA+ E
Sbjct: 1237 PLADSQAVREQLRQEQA-LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1295
Query: 692 WISEKTKKIKEVTVRGLEPEIQKLI--ARHKQEVRRLKSLHEAELLQSDERASQRCLRQA 749
++ KK K + G E IQ+ + H E+ L S + + ++ LR+
Sbjct: 1296 -VASPAKKPKVQS--GSESVIQEYVDLRTHYSELTTLTSQYIKFISET--------LRRM 1344
Query: 750 EELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAA 809
EE +E L +Q+R R+R L + + AL++QRQ +AE + QA
Sbjct: 1345 EE--------EERLAEQQRAEERER----LAEVEAALEKQRQ-----LAEAHAQAKAQAE 1387
Query: 810 RQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELE-----RQ 864
R E +EL+Q+++E R E ++Q+R Q EL L+Q E E RQ
Sbjct: 1388 R---EAKELQQRMQEEV-----VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1439
Query: 865 AWEAGRTR---KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES 921
A A R+R +EE ++ + E E R G + E++ + R E A ++ E+A
Sbjct: 1440 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA--- 1496
Query: 922 RIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQA 981
+RLR + + E Q+E +L R EAE R+K+RAL+ +
Sbjct: 1497 --ERLRRQVQDESQRKRQAEVELASRVK------AEAEA--------AREKQRALQALEE 1540
Query: 982 VNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTAL 1041
+ Q L Q + A E R A+AEL + +A E +++ +L
Sbjct: 1541 LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA----SFAEKTAQLERSL 1596
Query: 1042 ARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 1074
+ AV+ LR + E ++ E E+ R
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629
Score = 81.3 bits (199), Expect = 5e-15
Identities = 124/568 (21%), Positives = 251/568 (44%), Gaps = 71/568 (12%)
Query: 552 VPEAGPGPLELGSEVSTSVMRLK-------LEVEEKKQAMLLLQRALAQQRDLTAR--RV 602
+PE P L SE+ ++ +L+ + +E+ K L+++ + L A ++
Sbjct: 1053 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1112
Query: 603 KETE---------KALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELK 653
KE + +A L++ R EA A D+L ++V E+ + E
Sbjct: 1113 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV-GERLQQRHGERD 1171
Query: 654 QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARRE-KWISEKTKKIKEVTVRGLEPEI 712
E +R ERVAQ +++ + +++ T+ +RE + + + + +E +P
Sbjct: 1172 VEVERWRERVAQL-------LERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADP-- 1218
Query: 713 QKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERAR 772
+ Q+ RR + +A L +D +A + LRQ + L E++ER E + +E +R
Sbjct: 1219 ---LGAWLQDARRRQEQIQAMPL-ADSQAVREQLRQEQALLEEIERHGEKV--EECQRFA 1272
Query: 773 QRFQQHLEQEQWAL---QQQRQRLYSEVAEERERLGQQAARQR--------AELEELRQQ 821
+++ ++ + L + Q + + S + + + G ++ Q +EL L Q
Sbjct: 1273 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1332
Query: 822 LEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNR 881
+ S R + E E+ E+Q + L ++ LE +RQ EA K +A
Sbjct: 1333 YIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA----- 1386
Query: 882 EQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAEL------- 934
E+E +E ++ +++ V+ R EA A+ ++ +++ + +++LR EAE+
Sbjct: 1387 EREAKELQQRMQEE----VVRREEA--AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1440
Query: 935 SELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLA 994
E+S +++E ++ QL E + +G ++ E+A+A Q E L
Sbjct: 1441 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1500
Query: 995 QVIRQEFEDRLAASEEETRQAKAELATLQARQQL--ELEEVHRRVKTALARKEEAVSSLR 1052
+ ++ E + + A E + KAE + +Q+ LEE+ + + A R +A
Sbjct: 1501 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1560
Query: 1053 TQHEAAVKRADHLEELLEQHRRPTPSTK 1080
Q + A++ A E Q +R + + K
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAEK 1588
Score = 57.4 bits (137), Expect = 7e-08
Identities = 95/384 (24%), Positives = 157/384 (40%), Gaps = 62/384 (16%)
Query: 728 SLHEAELLQS------DERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQ 781
S H +LLQS +E QRC+ + +++R QLE + R R + L++
Sbjct: 962 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE--------TRTVHRLRLPLDK 1013
Query: 782 EQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGR 841
E QR + E E LG+ AR AE E++ E S +A T E G+
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073
Query: 842 EEQERR----HQMELNTLKQQLELERQAWEAGRTRKEE--------AWLLNRE------- 882
EQ R + +L T+ + + A E R +E+ A L E
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1133
Query: 883 -------------QELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDK 929
LR+E+R ++ V RL+ E E+ E R+ +L ++
Sbjct: 1134 KLRAQAEAQQPTFDALRDELRGAQE-----VGERLQQRHGERDVEVERWRE-RVAQLLER 1187
Query: 930 YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKER----ALEDAQAVNEQ 985
++A L++ + +R+L++ +L+ A+ LQ R++E+ L D+QAV EQ
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ-QLELEEVHRRVKTALARK 1044
L E Q + +E E EE R AK + ++ + QL + + A+K
Sbjct: 1248 LRQE-----QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1302
Query: 1045 EEAVSSLRTQHEAAVKRADHLEEL 1068
+ S + + V H EL
Sbjct: 1303 PKVQSGSESVIQEYVDLRTHYSEL 1326
Score = 39.7 bits (91), Expect = 0.016
Identities = 96/429 (22%), Positives = 180/429 (41%), Gaps = 71/429 (16%)
Query: 627 HLAFIDQLIEDKKVLSE----KC-EAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELM 681
H+A +++ +K++ SE +C + +V +L+ E C E++ QA A + +++ L+
Sbjct: 374 HVAILER---EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR----LL 426
Query: 682 SATEKARREKWISEKTKKIKEVTVRGLEPEIQKLI-ARH---KQEVRRLKSLHEAELLQS 737
+A + +R + K + +R L ++Q L RH +Q RR+ LHE +
Sbjct: 427 AAGKVPQRAGEVERDLDKADSM-IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR 485
Query: 738 DERASQRCLRQAEELREQLEREKEALGQQ-ERERARQRFQQHLEQEQWALQQQRQRLYSE 796
E + A + + +++ ++ E E + R+ Q L W + Q + +E
Sbjct: 486 TEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA--WVEENQHRVDGAE 543
Query: 797 VAEERERLGQQAARQRA---ELEELRQQLEESSS---ALTRALRAEFEKGREEQERRHQM 850
+ + Q R +EE R ++E + S L+ A R + + ++
Sbjct: 544 WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 603
Query: 851 ELNTLKQQLE-LERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMA 909
LN+ K +L LE KE WL +E+E E D+ + + E+ A
Sbjct: 604 LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE--EVGFDWSDRNTNMTAKK-ESYSA 660
Query: 910 LAKEESEKAAESRIKRLRDKYEAELSE-------LEQSERKLQERCS------------- 949
L +E K E +IK L++ + L E +E + LQ + S
Sbjct: 661 LMRELELK--EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 718
Query: 950 -------ELKGQLGEAEGENLRLQGLVRQK------------ERALEDAQAVNEQLSSER 990
+ + EAEG+ +LQ +R+K E L+DAQ EQL+ +
Sbjct: 719 KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 778
Query: 991 SNLAQVIRQ 999
+L+ + ++
Sbjct: 779 GHLSGLAKR 787
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 150 bits (380), Expect = 5e-36
Identities = 209/886 (23%), Positives = 356/886 (40%), Gaps = 131/886 (14%)
Query: 280 RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA 339
R ++ A + L +A + + Q E L Q+E RR+ A+Q +R+
Sbjct: 1363 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1422
Query: 340 IQELQQKRA-------LRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL 392
+ELQQ R +A++A AER E RV ++ A E QAL
Sbjct: 1423 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1482
Query: 393 KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK 452
+A R + Q+ E + V + E+ SR A+
Sbjct: 1483 RA--------------RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1528
Query: 453 SRGPLE-----ELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGK 507
+ E + L L+L +E + R R R + E S A E K
Sbjct: 1529 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA---ELQSK 1585
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
++F E + + ++ +E E+ Q Q ++++ E LE +
Sbjct: 1586 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER---AREEAERELERWQLKA 1642
Query: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA----------LSRQLQRQR 617
+RL+L+ EE Q L Q +Q++ R + KA ++L++QR
Sbjct: 1643 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1702
Query: 618 EHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKL 677
+ E T Q+ LA +LI + A + +Q+ Q E +A+ Q + +K
Sbjct: 1703 QLAEGTAQQRLAAEQELI--------RLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1754
Query: 678 KELMSATEKARREKWI--------SEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSL 729
+EL + K R E + E+++ E + + LE E + +E RL++L
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARLRAL 1813
Query: 730 HEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQ 789
E E + + A + RQ E L + A+G+ R + +E+ A ++
Sbjct: 1814 AE-EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL---KEKEAENER 1869
Query: 790 RQRLYSEVAEERERLGQQAARQRAELEELRQQLEESS-SALTR----------------- 831
+RL + A +R RL +QAA+ +A++EE QL ++S S L R
Sbjct: 1870 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1929
Query: 832 ---ALRAEFEK---GREEQERRHQMELNTLKQQLE-----LERQAWEAGRTRKEEAWLLN 880
AL+A FEK G+ E E +EL ++ E E+ EA R R+ A
Sbjct: 1930 EILALKASFEKAAAGKAELE----LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1985
Query: 881 REQELREEIRKGRDKEIELV---------IHRLEADMALAKEESEKAA-----------E 920
R +E E ++K E E + RL+A + A+ E+A E
Sbjct: 1986 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2045
Query: 921 SRIKRLRDKYEAELSELEQSERKLQERCSELKGQL----GEAEG--------ENLRLQGL 968
+ KRL+ + +A ++Q E++LQ+ + + L GEAE E R+Q
Sbjct: 2046 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2105
Query: 969 --VRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ 1026
Q R +E+A+ + + + AQ + R A +E R+A+AE A L+ +Q
Sbjct: 2106 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ 2165
Query: 1027 QLELE-EVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1071
+ E E H++ R++ V T ++ DH + LL++
Sbjct: 2166 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2211
Score = 135 bits (339), Expect = 3e-31
Identities = 238/962 (24%), Positives = 398/962 (41%), Gaps = 146/962 (15%)
Query: 245 GGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQ 304
GG+ G + EEAE Q + ++R + + QR+ L ++A+ E
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1532
Query: 305 RQRSGE-GTLLDLHQQKEAARRKARE---EKARQ-------ARRAAIQELQQKRALRAQK 353
R++ L +L Q E A R+ R+ E+ARQ A+R+A ELQ KRA A+K
Sbjct: 1533 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1592
Query: 354 ASTAERGPPE---------NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAA 404
+ ER E E R + + LKAN A
Sbjct: 1593 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1652
Query: 405 GPGDRCLPTSDSSPEPQQPPEDR---------TQDVLAQDAAGDNLEMMAP-SRGSAKSR 454
+ + + E Q+ +R Q V ++ A LE + G+A+ R
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1712
Query: 455 GPLEELLHTL-----------QLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLE 503
E+ L L QLLE+E R A ++ + L E
Sbjct: 1713 LAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAELAKVRAE 1767
Query: 504 KFGKLSAFPEPPEDGTLLSEAKLQSIMS----FLDEMEKSGQ-----DQLDSQQEGWVPE 554
L++ E+ SE Q + + F + E++ + ++ Q++ +
Sbjct: 1768 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1827
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
A E ++ + + K +A + L+ A+ L RR+ E E R+L+
Sbjct: 1828 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLE 1885
Query: 615 RQREHYEATIQRHLAFI----DQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQ 667
Q ++A I+ LA + D +E +K L E ++++E + E+ A +
Sbjct: 1886 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1945
Query: 668 AQHELEIKKLK----ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
A+ ELE+ +++ + + + E+A E + +E R E +QK +A ++
Sbjct: 1946 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2005
Query: 724 RRLK-SLHEAELLQSD--------ERASQRCLRQ------AEELREQLEREKEALGQQER 768
R+ K +L E E L++ ERA Q RQ A + R Q E + A Q++
Sbjct: 2006 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065
Query: 769 ERARQRFQQHLEQEQWALQQQR-----QRLYSEVAEE----RERLGQQAARQRAELEELR 819
E Q QQ L+QEQ L Q R R +E AEE ER Q+ RQ E E L+
Sbjct: 2066 E---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2122
Query: 820 QQLEESSSALTRALRAEFEKGREEQE----RRHQMELNTLKQQ----LELERQAWEAGRT 871
Q EE + A +A +A EK R+E E RR Q E L+Q+ E+E+ A +T
Sbjct: 2123 QSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2181
Query: 872 RKEEAWLLNREQELREEIRKGRDKE--IELVIHRLEADMALAKEESEKAAE--------- 920
+++A + LR ++ + ++ ++ + RL+A+ A + + E
Sbjct: 2182 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2241
Query: 921 SRIKRLRDKYEAE-----LSELEQSERKLQERCSELK------GQLGEAEGENLRLQGLV 969
+ +L+ + EAE L + + ++R LQE ++K +L A E RL+ L
Sbjct: 2242 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2301
Query: 970 RQ---KERAL------EDAQAVNE--QLSSERSNLAQ--VIRQEFEDRLAASEEETRQAK 1016
+ ++RAL E QAV E +L +E L Q + QE RL +E+ Q
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2361
Query: 1017 AE-----LATLQA--RQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELL 1069
AE TL+A ++QLE+ R+K +A A + + K+A+ + E L
Sbjct: 2362 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421
Query: 1070 EQ 1071
+
Sbjct: 2422 HR 2423
Score = 129 bits (325), Expect = 1e-29
Identities = 220/871 (25%), Positives = 371/871 (42%), Gaps = 121/871 (13%)
Query: 252 RRKEVTEEEAERFIHQVNQATV--TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
+ K+ E EA RF +A + + Q Q AAR + E+ G
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1847
Query: 310 EGTLLDLH-----QQKEAARRKAR---EEKARQARRAAIQELQQK-----RALRAQKAST 356
E T L ++KEA + R E++A Q RR Q Q K R + +KAS
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907
Query: 357 AERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS 416
+E + E + RQ +E+ ALKA+ AAG + L
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEIL---------ALKASFEKA---AAGKAELELELGRI 1955
Query: 417 SPEPQQPPEDRTQDVLA-----QDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q L Q AA + KS EE + +E
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ L + + R +E++ A L +L A + E +LQ +
Sbjct: 2016 ERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL- 2073
Query: 532 FLDEMEKSGQDQLDSQQEGW---VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ 588
+ E+S DQL + E EA ++ E + S +++ E E KQ+
Sbjct: 2074 ---QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2129
Query: 589 RALAQQRDLTARRVKETEKALSRQLQ------RQREHYEATIQRHLAFIDQLIEDKKVLS 642
+A AQ + + KE E+ +R+ Q RQ++ +A +++H F +Q + K +
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2189
Query: 643 EKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKE 702
++ + +L++ D + + + E+++LK ATE AR+ + E+
Sbjct: 2190 QELTTLRLQLEETDHQ--------KNLLDEELQRLKA--EATEAARQRSQVEEEL----- 2234
Query: 703 VTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEA 762
+VR E+ KL AR + E R L + D+ +QR L++ E +Q+ E
Sbjct: 2235 FSVRVQMEELSKLKARIEAENRAL--------ILRDKDNTQRFLQEEAEKMKQVAEEAAR 2286
Query: 763 LGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQL 822
L +E AR R L +E A Q++ L ++ +E+ + Q+A R +AE E L+QQ
Sbjct: 2287 LSVAAQEAARLR---QLAEEDLA---QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2340
Query: 823 EESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQ-----AWEAGRTRKEEAW 877
E + R ++ +E+ ++ E ++ LE ERQ + EA R + A
Sbjct: 2341 ELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2395
Query: 878 LLNREQELREEIRKGRDK--EIELVIHRLEADMALAKEESEKAAES-RIKRLRDKYEAE- 933
+ + E+ ++ R + EI +HR E LA +E ++ I+R + ++AE
Sbjct: 2396 MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAER 2451
Query: 934 ----LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSE 989
++ELE+ + KLQ+ L QL E + + Q+E+ L++ QA+ + SE
Sbjct: 2452 LREAIAELEREKEKLQQEAKLL--QLKSEEMQTV-------QQEQLLQETQALQQSFLSE 2502
Query: 990 RSNLAQVIRQEFEDRLAASEEETRQ---AKAE-LATLQARQQLELEEVHRRVKTALARKE 1045
+ +L Q R+ F ++ A E+ Q AKA+ L Q RQQ ++E+ +R+ +A E
Sbjct: 2503 KDSLLQ--RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASME 2557
Query: 1046 EAVSSLRTQHEA--AVKRADHLEELLEQHRR 1074
EA R QHEA V+R + LEQ RR
Sbjct: 2558 EA---RRRQHEAEEGVRRKQEELQQLEQQRR 2585
Score = 108 bits (269), Expect = 4e-23
Identities = 194/856 (22%), Positives = 346/856 (40%), Gaps = 105/856 (12%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG 287
++ K++++ +AR + R K EE A R + Q + + + Q+R
Sbjct: 1993 RVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERAEQESARQLQLAQEAAQKRL 2051
Query: 288 AGAARLEHLLQAKREEQRQRS--GEGTLLD-LHQQKEAARRKARE-EKAR-QARRAAIQE 342
+ ++E++ Q++ E ++LD L + EAARR A E E+AR QA R A Q
Sbjct: 2052 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2111
Query: 343 LQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLP 402
+Q K S E+ + +R+ A++ + AL+
Sbjct: 2112 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA----- 2166
Query: 403 AAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLH 462
+D+ E + ++T AQ + R LEE H
Sbjct: 2167 -----------ADAEMEKHKKFAEQTLRQKAQ-----------VEQELTTLRLQLEETDH 2204
Query: 463 TLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS 522
LL++E L T + + EE + + +E+ KL A E +L
Sbjct: 2205 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV---QMEELSKLKARIEAENRALILR 2261
Query: 523 EAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQ 582
+ D ++ Q++ + ++ V+ RL + +E +
Sbjct: 2262 DK---------DNTQRFLQEEAEKMKQ----------------VAEEAARLSVAAQEAAR 2296
Query: 583 AMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFID--QLIEDKKV 640
L + LAQQR L + +KE +A+ + + E Q+ LA +L EDK+
Sbjct: 2297 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2356
Query: 641 LSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKI 700
++++ +AE Q QR E Q Q + E ++LK + E +R + E ++
Sbjct: 2357 MAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLK--LRVAEMSRAQARAEEDAQRF 2410
Query: 701 KEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELRE---QLE 757
++ E +KL H+ E L + + L+Q+ E Q+ AE LRE +LE
Sbjct: 2411 RKQA----EEIGEKL---HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460
Query: 758 REKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEE 817
REKE L QQE + + + ++ +Q L Q+ Q L E++ L Q+ E +
Sbjct: 2461 REKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2519
Query: 818 LRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAW 877
L +QL + A + LR E ++ +++ E+ Q + ++++ + +A E R ++EE
Sbjct: 2520 L-EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2578
Query: 878 LLNREQELREEIRKGRDKEIELVIHRLEAD--MALAKEE----SEKAAESRIKRLRDKYE 931
L +++ +EE+ ++ + + LE ALA E S+ AA + RD +
Sbjct: 2579 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2638
Query: 932 AELSELEQS------ERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQ 985
+E E RK+ + + G L E + L QG E L + V
Sbjct: 2639 GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL-AQGHTTVDE--LARREDVRHY 2695
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAE-----LATLQARQQLELEEVHRRVKTA 1040
L RS++A ++ + ++L+ RQ + L QA L+ V R T
Sbjct: 2696 LQG-RSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTV 2754
Query: 1041 LARKEEAVSSLRTQHE 1056
+E V H+
Sbjct: 2755 NEAVKEGVVGPELHHK 2770
Score = 95.1 bits (235), Expect = 3e-19
Identities = 174/693 (25%), Positives = 293/693 (42%), Gaps = 109/693 (15%)
Query: 418 PEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRP 477
P ++P + Q + Q A +E + +G A+ E++L P+ P
Sbjct: 1014 PLDKEPARECAQRIAEQQKAQAEVEGLG--KGVARLSAEAEKVLAL-------PEPSPAA 1064
Query: 478 RTHHRGRYAWASEEDDASSLTADNLEKFGKLSAF---PEPPEDGTLLSEAKL---QSIMS 531
T + + SL+A LEK +S + E+ E +L Q++ +
Sbjct: 1065 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1124
Query: 532 FLDEME--KSGQDQLDSQQEGWVPEAGP------GPLELGSEVSTSVMRLKLEVEE-KKQ 582
L E+E K+ +L +Q E P G E+G + +EVE +++
Sbjct: 1125 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1184
Query: 583 AMLLLQR--ALAQQRDLTARRVKETEKALSRQLQRQREHYE---ATIQRHLAFIDQL--- 634
LL+R A+ Q D+ R +++ L RQL+ RE + A +Q +Q+
Sbjct: 1185 VAQLLERWQAVLAQTDVRQRELEQ----LGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1240
Query: 635 -IEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLK--ELMSATEKARREK 691
+ D + + E+ A L +E +R E+V + Q + I +K EL T KA+ E
Sbjct: 1241 PLADSQAVREQLRQEQA-LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1299
Query: 692 WISEKTKKIKEVTVRGLEPEIQKLI--ARHKQEVRRLKSLHEAELLQSDERASQRCLRQA 749
++ KK K + G E IQ+ + H E+ L S + + ++ LR+
Sbjct: 1300 -VASPAKKPKVQS--GSESVIQEYVDLRTHYSELTTLTSQYIKFISET--------LRRM 1348
Query: 750 EELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAA 809
EE +E L +Q+R R+R L + + AL++QRQ +AE + QA
Sbjct: 1349 EE--------EERLAEQQRAEERER----LAEVEAALEKQRQ-----LAEAHAQAKAQAE 1391
Query: 810 RQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELE-----RQ 864
R E +EL+Q+++E R E ++Q+R Q EL L+Q E E RQ
Sbjct: 1392 R---EAKELQQRMQEEV-----VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1443
Query: 865 AWEAGRTR---KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES 921
A A R+R +EE ++ + E E R G + E++ + R E A ++ E+A
Sbjct: 1444 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA--- 1500
Query: 922 RIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQA 981
+RLR + + E Q+E +L R EAE R+K+RAL+ +
Sbjct: 1501 --ERLRRQVQDESQRKRQAEVELASRVK------AEAEA--------AREKQRALQALEE 1544
Query: 982 VNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTAL 1041
+ Q L Q + A E R A+AEL + +A E +++ +L
Sbjct: 1545 LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA----SFAEKTAQLERSL 1600
Query: 1042 ARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 1074
+ AV+ LR + E ++ E E+ R
Sbjct: 1601 QEEHVAVAQLREEAERRAQQQAEAERAREEAER 1633
Score = 81.3 bits (199), Expect = 5e-15
Identities = 124/568 (21%), Positives = 251/568 (44%), Gaps = 71/568 (12%)
Query: 552 VPEAGPGPLELGSEVSTSVMRLK-------LEVEEKKQAMLLLQRALAQQRDLTAR--RV 602
+PE P L SE+ ++ +L+ + +E+ K L+++ + L A ++
Sbjct: 1057 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1116
Query: 603 KETE---------KALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELK 653
KE + +A L++ R EA A D+L ++V E+ + E
Sbjct: 1117 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV-GERLQQRHGERD 1175
Query: 654 QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARRE-KWISEKTKKIKEVTVRGLEPEI 712
E +R ERVAQ +++ + +++ T+ +RE + + + + +E +P
Sbjct: 1176 VEVERWRERVAQL-------LERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADP-- 1222
Query: 713 QKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERAR 772
+ Q+ RR + +A L +D +A + LRQ + L E++ER E + +E +R
Sbjct: 1223 ---LGAWLQDARRRQEQIQAMPL-ADSQAVREQLRQEQALLEEIERHGEKV--EECQRFA 1276
Query: 773 QRFQQHLEQEQWAL---QQQRQRLYSEVAEERERLGQQAARQR--------AELEELRQQ 821
+++ ++ + L + Q + + S + + + G ++ Q +EL L Q
Sbjct: 1277 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1336
Query: 822 LEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNR 881
+ S R + E E+ E+Q + L ++ LE +RQ EA K +A
Sbjct: 1337 YIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA----- 1390
Query: 882 EQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAEL------- 934
E+E +E ++ +++ V+ R EA A+ ++ +++ + +++LR EAE+
Sbjct: 1391 EREAKELQQRMQEE----VVRREEA--AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1444
Query: 935 SELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLA 994
E+S +++E ++ QL E + +G ++ E+A+A Q E L
Sbjct: 1445 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1504
Query: 995 QVIRQEFEDRLAASEEETRQAKAELATLQARQQL--ELEEVHRRVKTALARKEEAVSSLR 1052
+ ++ E + + A E + KAE + +Q+ LEE+ + + A R +A
Sbjct: 1505 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1564
Query: 1053 TQHEAAVKRADHLEELLEQHRRPTPSTK 1080
Q + A++ A E Q +R + + K
Sbjct: 1565 RQVQVALETAQRSAEAELQSKRASFAEK 1592
Score = 57.4 bits (137), Expect = 7e-08
Identities = 95/384 (24%), Positives = 157/384 (40%), Gaps = 62/384 (16%)
Query: 728 SLHEAELLQS------DERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQ 781
S H +LLQS +E QRC+ + +++R QLE + R R + L++
Sbjct: 966 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE--------TRTVHRLRLPLDK 1017
Query: 782 EQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGR 841
E QR + E E LG+ AR AE E++ E S +A T E G+
Sbjct: 1018 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1077
Query: 842 EEQERR----HQMELNTLKQQLELERQAWEAGRTRKEE--------AWLLNRE------- 882
EQ R + +L T+ + + A E R +E+ A L E
Sbjct: 1078 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1137
Query: 883 -------------QELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDK 929
LR+E+R ++ V RL+ E E+ E R+ +L ++
Sbjct: 1138 KLRAQAEAQQPTFDALRDELRGAQE-----VGERLQQRHGERDVEVERWRE-RVAQLLER 1191
Query: 930 YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKER----ALEDAQAVNEQ 985
++A L++ + +R+L++ +L+ A+ LQ R++E+ L D+QAV EQ
Sbjct: 1192 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1251
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ-QLELEEVHRRVKTALARK 1044
L E Q + +E E EE R AK + ++ + QL + + A+K
Sbjct: 1252 LRQE-----QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1306
Query: 1045 EEAVSSLRTQHEAAVKRADHLEEL 1068
+ S + + V H EL
Sbjct: 1307 PKVQSGSESVIQEYVDLRTHYSEL 1330
Score = 39.7 bits (91), Expect = 0.016
Identities = 96/429 (22%), Positives = 180/429 (41%), Gaps = 71/429 (16%)
Query: 627 HLAFIDQLIEDKKVLSE----KC-EAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELM 681
H+A +++ +K++ SE +C + +V +L+ E C E++ QA A + +++ L+
Sbjct: 378 HVAILER---EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR----LL 430
Query: 682 SATEKARREKWISEKTKKIKEVTVRGLEPEIQKLI-ARH---KQEVRRLKSLHEAELLQS 737
+A + +R + K + +R L ++Q L RH +Q RR+ LHE +
Sbjct: 431 AAGKVPQRAGEVERDLDKADSM-IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR 489
Query: 738 DERASQRCLRQAEELREQLEREKEALGQQ-ERERARQRFQQHLEQEQWALQQQRQRLYSE 796
E + A + + +++ ++ E E + R+ Q L W + Q + +E
Sbjct: 490 TEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA--WVEENQHRVDGAE 547
Query: 797 VAEERERLGQQAARQRA---ELEELRQQLEESSS---ALTRALRAEFEKGREEQERRHQM 850
+ + Q R +EE R ++E + S L+ A R + + ++
Sbjct: 548 WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 607
Query: 851 ELNTLKQQLE-LERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMA 909
LN+ K +L LE KE WL +E+E E D+ + + E+ A
Sbjct: 608 LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE--EVGFDWSDRNTNMTAKK-ESYSA 664
Query: 910 LAKEESEKAAESRIKRLRDKYEAELSE-------LEQSERKLQERCS------------- 949
L +E K E +IK L++ + L E +E + LQ + S
Sbjct: 665 LMRELELK--EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 722
Query: 950 -------ELKGQLGEAEGENLRLQGLVRQK------------ERALEDAQAVNEQLSSER 990
+ + EAEG+ +LQ +R+K E L+DAQ EQL+ +
Sbjct: 723 KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 782
Query: 991 SNLAQVIRQ 999
+L+ + ++
Sbjct: 783 GHLSGLAKR 791
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 150 bits (380), Expect = 5e-36
Identities = 209/886 (23%), Positives = 356/886 (40%), Gaps = 131/886 (14%)
Query: 280 RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA 339
R ++ A + L +A + + Q E L Q+E RR+ A+Q +R+
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 340 IQELQQKRA-------LRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL 392
+ELQQ R +A++A AER E RV ++ A E QAL
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Query: 393 KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK 452
+A R + Q+ E + V + E+ SR A+
Sbjct: 1479 RA--------------RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524
Query: 453 SRGPLE-----ELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGK 507
+ E + L L+L +E + R R R + E S A E K
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA---ELQSK 1581
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
++F E + + ++ +E E+ Q Q ++++ E LE +
Sbjct: 1582 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER---AREEAERELERWQLKA 1638
Query: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA----------LSRQLQRQR 617
+RL+L+ EE Q L Q +Q++ R + KA ++L++QR
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 618 EHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKL 677
+ E T Q+ LA +LI + A + +Q+ Q E +A+ Q + +K
Sbjct: 1699 QLAEGTAQQRLAAEQELI--------RLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750
Query: 678 KELMSATEKARREKWI--------SEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSL 729
+EL + K R E + E+++ E + + LE E + +E RL++L
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARLRAL 1809
Query: 730 HEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQ 789
E E + + A + RQ E L + A+G+ R + +E+ A ++
Sbjct: 1810 AE-EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL---KEKEAENER 1865
Query: 790 RQRLYSEVAEERERLGQQAARQRAELEELRQQLEESS-SALTR----------------- 831
+RL + A +R RL +QAA+ +A++EE QL ++S S L R
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 832 ---ALRAEFEK---GREEQERRHQMELNTLKQQLE-----LERQAWEAGRTRKEEAWLLN 880
AL+A FEK G+ E E +EL ++ E E+ EA R R+ A
Sbjct: 1926 EILALKASFEKAAAGKAELE----LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981
Query: 881 REQELREEIRKGRDKEIELV---------IHRLEADMALAKEESEKAA-----------E 920
R +E E ++K E E + RL+A + A+ E+A E
Sbjct: 1982 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2041
Query: 921 SRIKRLRDKYEAELSELEQSERKLQERCSELKGQL----GEAEG--------ENLRLQGL 968
+ KRL+ + +A ++Q E++LQ+ + + L GEAE E R+Q
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2101
Query: 969 --VRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ 1026
Q R +E+A+ + + + AQ + R A +E R+A+AE A L+ +Q
Sbjct: 2102 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ 2161
Query: 1027 QLELE-EVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1071
+ E E H++ R++ V T ++ DH + LL++
Sbjct: 2162 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Score = 135 bits (339), Expect = 3e-31
Identities = 238/962 (24%), Positives = 398/962 (41%), Gaps = 146/962 (15%)
Query: 245 GGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQ 304
GG+ G + EEAE Q + ++R + + QR+ L ++A+ E
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528
Query: 305 RQRSGE-GTLLDLHQQKEAARRKARE---EKARQ-------ARRAAIQELQQKRALRAQK 353
R++ L +L Q E A R+ R+ E+ARQ A+R+A ELQ KRA A+K
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588
Query: 354 ASTAERGPPE---------NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAA 404
+ ER E E R + + LKAN A
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 405 GPGDRCLPTSDSSPEPQQPPEDR---------TQDVLAQDAAGDNLEMMAP-SRGSAKSR 454
+ + + E Q+ +R Q V ++ A LE + G+A+ R
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 455 GPLEELLHTL-----------QLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLE 503
E+ L L QLLE+E R A ++ + L E
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAELAKVRAE 1763
Query: 504 KFGKLSAFPEPPEDGTLLSEAKLQSIMS----FLDEMEKSGQ-----DQLDSQQEGWVPE 554
L++ E+ SE Q + + F + E++ + ++ Q++ +
Sbjct: 1764 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1823
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
A E ++ + + K +A + L+ A+ L RR+ E E R+L+
Sbjct: 1824 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLE 1881
Query: 615 RQREHYEATIQRHLAFI----DQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQ 667
Q ++A I+ LA + D +E +K L E ++++E + E+ A +
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Query: 668 AQHELEIKKLK----ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
A+ ELE+ +++ + + + E+A E + +E R E +QK +A ++
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 724 RRLK-SLHEAELLQSD--------ERASQRCLRQ------AEELREQLEREKEALGQQER 768
R+ K +L E E L++ ERA Q RQ A + R Q E + A Q++
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 769 ERARQRFQQHLEQEQWALQQQR-----QRLYSEVAEE----RERLGQQAARQRAELEELR 819
E Q QQ L+QEQ L Q R R +E AEE ER Q+ RQ E E L+
Sbjct: 2062 E---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2118
Query: 820 QQLEESSSALTRALRAEFEKGREEQE----RRHQMELNTLKQQ----LELERQAWEAGRT 871
Q EE + A +A +A EK R+E E RR Q E L+Q+ E+E+ A +T
Sbjct: 2119 QSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177
Query: 872 RKEEAWLLNREQELREEIRKGRDKE--IELVIHRLEADMALAKEESEKAAE--------- 920
+++A + LR ++ + ++ ++ + RL+A+ A + + E
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2237
Query: 921 SRIKRLRDKYEAE-----LSELEQSERKLQERCSELK------GQLGEAEGENLRLQGLV 969
+ +L+ + EAE L + + ++R LQE ++K +L A E RL+ L
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 970 RQ---KERAL------EDAQAVNE--QLSSERSNLAQ--VIRQEFEDRLAASEEETRQAK 1016
+ ++RAL E QAV E +L +E L Q + QE RL +E+ Q
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 1017 AE-----LATLQA--RQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELL 1069
AE TL+A ++QLE+ R+K +A A + + K+A+ + E L
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 1070 EQ 1071
+
Sbjct: 2418 HR 2419
Score = 129 bits (325), Expect = 1e-29
Identities = 220/871 (25%), Positives = 371/871 (42%), Gaps = 121/871 (13%)
Query: 252 RRKEVTEEEAERFIHQVNQATV--TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
+ K+ E EA RF +A + + Q Q AAR + E+ G
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843
Query: 310 EGTLLDLH-----QQKEAARRKAR---EEKARQARRAAIQELQQK-----RALRAQKAST 356
E T L ++KEA + R E++A Q RR Q Q K R + +KAS
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 357 AERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS 416
+E + E + RQ +E+ ALKA+ AAG + L
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEIL---------ALKASFEKA---AAGKAELELELGRI 1951
Query: 417 SPEPQQPPEDRTQDVLA-----QDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q L Q AA + KS EE + +E
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ L + + R +E++ A L +L A + E +LQ +
Sbjct: 2012 ERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL- 2069
Query: 532 FLDEMEKSGQDQLDSQQEGW---VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ 588
+ E+S DQL + E EA ++ E + S +++ E E KQ+
Sbjct: 2070 ---QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2125
Query: 589 RALAQQRDLTARRVKETEKALSRQLQ------RQREHYEATIQRHLAFIDQLIEDKKVLS 642
+A AQ + + KE E+ +R+ Q RQ++ +A +++H F +Q + K +
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 643 EKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKE 702
++ + +L++ D + + + E+++LK ATE AR+ + E+
Sbjct: 2186 QELTTLRLQLEETDHQ--------KNLLDEELQRLKA--EATEAARQRSQVEEEL----- 2230
Query: 703 VTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEA 762
+VR E+ KL AR + E R L + D+ +QR L++ E +Q+ E
Sbjct: 2231 FSVRVQMEELSKLKARIEAENRAL--------ILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 763 LGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQL 822
L +E AR R L +E A Q++ L ++ +E+ + Q+A R +AE E L+QQ
Sbjct: 2283 LSVAAQEAARLR---QLAEEDLA---QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336
Query: 823 EESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQ-----AWEAGRTRKEEAW 877
E + R ++ +E+ ++ E ++ LE ERQ + EA R + A
Sbjct: 2337 ELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2391
Query: 878 LLNREQELREEIRKGRDK--EIELVIHRLEADMALAKEESEKAAES-RIKRLRDKYEAE- 933
+ + E+ ++ R + EI +HR E LA +E ++ I+R + ++AE
Sbjct: 2392 MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAER 2447
Query: 934 ----LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSE 989
++ELE+ + KLQ+ L QL E + + Q+E+ L++ QA+ + SE
Sbjct: 2448 LREAIAELEREKEKLQQEAKLL--QLKSEEMQTV-------QQEQLLQETQALQQSFLSE 2498
Query: 990 RSNLAQVIRQEFEDRLAASEEETRQ---AKAE-LATLQARQQLELEEVHRRVKTALARKE 1045
+ +L Q R+ F ++ A E+ Q AKA+ L Q RQQ ++E+ +R+ +A E
Sbjct: 2499 KDSLLQ--RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASME 2553
Query: 1046 EAVSSLRTQHEA--AVKRADHLEELLEQHRR 1074
EA R QHEA V+R + LEQ RR
Sbjct: 2554 EA---RRRQHEAEEGVRRKQEELQQLEQQRR 2581
Score = 108 bits (269), Expect = 4e-23
Identities = 194/856 (22%), Positives = 346/856 (40%), Gaps = 105/856 (12%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG 287
++ K++++ +AR + R K EE A R + Q + + + Q+R
Sbjct: 1989 RVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERAEQESARQLQLAQEAAQKRL 2047
Query: 288 AGAARLEHLLQAKREEQRQRS--GEGTLLD-LHQQKEAARRKARE-EKAR-QARRAAIQE 342
+ ++E++ Q++ E ++LD L + EAARR A E E+AR QA R A Q
Sbjct: 2048 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107
Query: 343 LQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLP 402
+Q K S E+ + +R+ A++ + AL+
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA----- 2162
Query: 403 AAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLH 462
+D+ E + ++T AQ + R LEE H
Sbjct: 2163 -----------ADAEMEKHKKFAEQTLRQKAQ-----------VEQELTTLRLQLEETDH 2200
Query: 463 TLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS 522
LL++E L T + + EE + + +E+ KL A E +L
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV---QMEELSKLKARIEAENRALILR 2257
Query: 523 EAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQ 582
+ D ++ Q++ + ++ V+ RL + +E +
Sbjct: 2258 DK---------DNTQRFLQEEAEKMKQ----------------VAEEAARLSVAAQEAAR 2292
Query: 583 AMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFID--QLIEDKKV 640
L + LAQQR L + +KE +A+ + + E Q+ LA +L EDK+
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 641 LSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKI 700
++++ +AE Q QR E Q Q + E ++LK + E +R + E ++
Sbjct: 2353 MAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLK--LRVAEMSRAQARAEEDAQRF 2406
Query: 701 KEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELRE---QLE 757
++ E +KL H+ E L + + L+Q+ E Q+ AE LRE +LE
Sbjct: 2407 RKQA----EEIGEKL---HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 758 REKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEE 817
REKE L QQE + + + ++ +Q L Q+ Q L E++ L Q+ E +
Sbjct: 2457 REKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2515
Query: 818 LRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAW 877
L +QL + A + LR E ++ +++ E+ Q + ++++ + +A E R ++EE
Sbjct: 2516 L-EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 878 LLNREQELREEIRKGRDKEIELVIHRLEAD--MALAKEE----SEKAAESRIKRLRDKYE 931
L +++ +EE+ ++ + + LE ALA E S+ AA + RD +
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2634
Query: 932 AELSELEQS------ERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQ 985
+E E RK+ + + G L E + L QG E L + V
Sbjct: 2635 GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL-AQGHTTVDE--LARREDVRHY 2691
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAE-----LATLQARQQLELEEVHRRVKTA 1040
L RS++A ++ + ++L+ RQ + L QA L+ V R T
Sbjct: 2692 LQG-RSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTV 2750
Query: 1041 LARKEEAVSSLRTQHE 1056
+E V H+
Sbjct: 2751 NEAVKEGVVGPELHHK 2766
Score = 95.1 bits (235), Expect = 3e-19
Identities = 174/693 (25%), Positives = 293/693 (42%), Gaps = 109/693 (15%)
Query: 418 PEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRP 477
P ++P + Q + Q A +E + +G A+ E++L P+ P
Sbjct: 1010 PLDKEPARECAQRIAEQQKAQAEVEGLG--KGVARLSAEAEKVLAL-------PEPSPAA 1060
Query: 478 RTHHRGRYAWASEEDDASSLTADNLEKFGKLSAF---PEPPEDGTLLSEAKL---QSIMS 531
T + + SL+A LEK +S + E+ E +L Q++ +
Sbjct: 1061 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1120
Query: 532 FLDEME--KSGQDQLDSQQEGWVPEAGP------GPLELGSEVSTSVMRLKLEVEE-KKQ 582
L E+E K+ +L +Q E P G E+G + +EVE +++
Sbjct: 1121 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1180
Query: 583 AMLLLQR--ALAQQRDLTARRVKETEKALSRQLQRQREHYE---ATIQRHLAFIDQL--- 634
LL+R A+ Q D+ R +++ L RQL+ RE + A +Q +Q+
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQ----LGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236
Query: 635 -IEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLK--ELMSATEKARREK 691
+ D + + E+ A L +E +R E+V + Q + I +K EL T KA+ E
Sbjct: 1237 PLADSQAVREQLRQEQA-LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1295
Query: 692 WISEKTKKIKEVTVRGLEPEIQKLI--ARHKQEVRRLKSLHEAELLQSDERASQRCLRQA 749
++ KK K + G E IQ+ + H E+ L S + + ++ LR+
Sbjct: 1296 -VASPAKKPKVQS--GSESVIQEYVDLRTHYSELTTLTSQYIKFISET--------LRRM 1344
Query: 750 EELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAA 809
EE +E L +Q+R R+R L + + AL++QRQ +AE + QA
Sbjct: 1345 EE--------EERLAEQQRAEERER----LAEVEAALEKQRQ-----LAEAHAQAKAQAE 1387
Query: 810 RQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELE-----RQ 864
R E +EL+Q+++E R E ++Q+R Q EL L+Q E E RQ
Sbjct: 1388 R---EAKELQQRMQEEV-----VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1439
Query: 865 AWEAGRTR---KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES 921
A A R+R +EE ++ + E E R G + E++ + R E A ++ E+A
Sbjct: 1440 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA--- 1496
Query: 922 RIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQA 981
+RLR + + E Q+E +L R EAE R+K+RAL+ +
Sbjct: 1497 --ERLRRQVQDESQRKRQAEVELASRVK------AEAEA--------AREKQRALQALEE 1540
Query: 982 VNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTAL 1041
+ Q L Q + A E R A+AEL + +A E +++ +L
Sbjct: 1541 LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA----SFAEKTAQLERSL 1596
Query: 1042 ARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 1074
+ AV+ LR + E ++ E E+ R
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629
Score = 81.3 bits (199), Expect = 5e-15
Identities = 124/568 (21%), Positives = 251/568 (44%), Gaps = 71/568 (12%)
Query: 552 VPEAGPGPLELGSEVSTSVMRLK-------LEVEEKKQAMLLLQRALAQQRDLTAR--RV 602
+PE P L SE+ ++ +L+ + +E+ K L+++ + L A ++
Sbjct: 1053 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1112
Query: 603 KETE---------KALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELK 653
KE + +A L++ R EA A D+L ++V E+ + E
Sbjct: 1113 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV-GERLQQRHGERD 1171
Query: 654 QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARRE-KWISEKTKKIKEVTVRGLEPEI 712
E +R ERVAQ +++ + +++ T+ +RE + + + + +E +P
Sbjct: 1172 VEVERWRERVAQL-------LERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADP-- 1218
Query: 713 QKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERAR 772
+ Q+ RR + +A L +D +A + LRQ + L E++ER E + +E +R
Sbjct: 1219 ---LGAWLQDARRRQEQIQAMPL-ADSQAVREQLRQEQALLEEIERHGEKV--EECQRFA 1272
Query: 773 QRFQQHLEQEQWAL---QQQRQRLYSEVAEERERLGQQAARQR--------AELEELRQQ 821
+++ ++ + L + Q + + S + + + G ++ Q +EL L Q
Sbjct: 1273 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1332
Query: 822 LEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNR 881
+ S R + E E+ E+Q + L ++ LE +RQ EA K +A
Sbjct: 1333 YIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA----- 1386
Query: 882 EQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAEL------- 934
E+E +E ++ +++ V+ R EA A+ ++ +++ + +++LR EAE+
Sbjct: 1387 EREAKELQQRMQEE----VVRREEA--AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1440
Query: 935 SELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLA 994
E+S +++E ++ QL E + +G ++ E+A+A Q E L
Sbjct: 1441 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1500
Query: 995 QVIRQEFEDRLAASEEETRQAKAELATLQARQQL--ELEEVHRRVKTALARKEEAVSSLR 1052
+ ++ E + + A E + KAE + +Q+ LEE+ + + A R +A
Sbjct: 1501 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1560
Query: 1053 TQHEAAVKRADHLEELLEQHRRPTPSTK 1080
Q + A++ A E Q +R + + K
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAEK 1588
Score = 57.4 bits (137), Expect = 7e-08
Identities = 95/384 (24%), Positives = 157/384 (40%), Gaps = 62/384 (16%)
Query: 728 SLHEAELLQS------DERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQ 781
S H +LLQS +E QRC+ + +++R QLE + R R + L++
Sbjct: 962 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE--------TRTVHRLRLPLDK 1013
Query: 782 EQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGR 841
E QR + E E LG+ AR AE E++ E S +A T E G+
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073
Query: 842 EEQERR----HQMELNTLKQQLELERQAWEAGRTRKEE--------AWLLNRE------- 882
EQ R + +L T+ + + A E R +E+ A L E
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1133
Query: 883 -------------QELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDK 929
LR+E+R ++ V RL+ E E+ E R+ +L ++
Sbjct: 1134 KLRAQAEAQQPTFDALRDELRGAQE-----VGERLQQRHGERDVEVERWRE-RVAQLLER 1187
Query: 930 YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKER----ALEDAQAVNEQ 985
++A L++ + +R+L++ +L+ A+ LQ R++E+ L D+QAV EQ
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ-QLELEEVHRRVKTALARK 1044
L E Q + +E E EE R AK + ++ + QL + + A+K
Sbjct: 1248 LRQE-----QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1302
Query: 1045 EEAVSSLRTQHEAAVKRADHLEEL 1068
+ S + + V H EL
Sbjct: 1303 PKVQSGSESVIQEYVDLRTHYSEL 1326
Score = 39.7 bits (91), Expect = 0.016
Identities = 96/429 (22%), Positives = 180/429 (41%), Gaps = 71/429 (16%)
Query: 627 HLAFIDQLIEDKKVLSE----KC-EAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELM 681
H+A +++ +K++ SE +C + +V +L+ E C E++ QA A + +++ L+
Sbjct: 374 HVAILER---EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR----LL 426
Query: 682 SATEKARREKWISEKTKKIKEVTVRGLEPEIQKLI-ARH---KQEVRRLKSLHEAELLQS 737
+A + +R + K + +R L ++Q L RH +Q RR+ LHE +
Sbjct: 427 AAGKVPQRAGEVERDLDKADSM-IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR 485
Query: 738 DERASQRCLRQAEELREQLEREKEALGQQ-ERERARQRFQQHLEQEQWALQQQRQRLYSE 796
E + A + + +++ ++ E E + R+ Q L W + Q + +E
Sbjct: 486 TEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA--WVEENQHRVDGAE 543
Query: 797 VAEERERLGQQAARQRA---ELEELRQQLEESSS---ALTRALRAEFEKGREEQERRHQM 850
+ + Q R +EE R ++E + S L+ A R + + ++
Sbjct: 544 WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 603
Query: 851 ELNTLKQQLE-LERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMA 909
LN+ K +L LE KE WL +E+E E D+ + + E+ A
Sbjct: 604 LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE--EVGFDWSDRNTNMTAKK-ESYSA 660
Query: 910 LAKEESEKAAESRIKRLRDKYEAELSE-------LEQSERKLQERCS------------- 949
L +E K E +IK L++ + L E +E + LQ + S
Sbjct: 661 LMRELELK--EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 718
Query: 950 -------ELKGQLGEAEGENLRLQGLVRQK------------ERALEDAQAVNEQLSSER 990
+ + EAEG+ +LQ +R+K E L+DAQ EQL+ +
Sbjct: 719 KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 778
Query: 991 SNLAQVIRQ 999
+L+ + ++
Sbjct: 779 GHLSGLAKR 787
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 150 bits (380), Expect = 5e-36
Identities = 209/886 (23%), Positives = 356/886 (40%), Gaps = 131/886 (14%)
Query: 280 RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA 339
R ++ A + L +A + + Q E L Q+E RR+ A+Q +R+
Sbjct: 1327 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1386
Query: 340 IQELQQKRA-------LRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL 392
+ELQQ R +A++A AER E RV ++ A E QAL
Sbjct: 1387 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1446
Query: 393 KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK 452
+A R + Q+ E + V + E+ SR A+
Sbjct: 1447 RA--------------RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1492
Query: 453 SRGPLE-----ELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGK 507
+ E + L L+L +E + R R R + E S A E K
Sbjct: 1493 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA---ELQSK 1549
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
++F E + + ++ +E E+ Q Q ++++ E LE +
Sbjct: 1550 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER---AREEAERELERWQLKA 1606
Query: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA----------LSRQLQRQR 617
+RL+L+ EE Q L Q +Q++ R + KA ++L++QR
Sbjct: 1607 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1666
Query: 618 EHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKL 677
+ E T Q+ LA +LI + A + +Q+ Q E +A+ Q + +K
Sbjct: 1667 QLAEGTAQQRLAAEQELI--------RLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1718
Query: 678 KELMSATEKARREKWI--------SEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSL 729
+EL + K R E + E+++ E + + LE E + +E RL++L
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARLRAL 1777
Query: 730 HEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQ 789
E E + + A + RQ E L + A+G+ R + +E+ A ++
Sbjct: 1778 AE-EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL---KEKEAENER 1833
Query: 790 RQRLYSEVAEERERLGQQAARQRAELEELRQQLEESS-SALTR----------------- 831
+RL + A +R RL +QAA+ +A++EE QL ++S S L R
Sbjct: 1834 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1893
Query: 832 ---ALRAEFEK---GREEQERRHQMELNTLKQQLE-----LERQAWEAGRTRKEEAWLLN 880
AL+A FEK G+ E E +EL ++ E E+ EA R R+ A
Sbjct: 1894 EILALKASFEKAAAGKAELE----LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1949
Query: 881 REQELREEIRKGRDKEIELV---------IHRLEADMALAKEESEKAA-----------E 920
R +E E ++K E E + RL+A + A+ E+A E
Sbjct: 1950 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2009
Query: 921 SRIKRLRDKYEAELSELEQSERKLQERCSELKGQL----GEAEG--------ENLRLQGL 968
+ KRL+ + +A ++Q E++LQ+ + + L GEAE E R+Q
Sbjct: 2010 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2069
Query: 969 --VRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ 1026
Q R +E+A+ + + + AQ + R A +E R+A+AE A L+ +Q
Sbjct: 2070 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ 2129
Query: 1027 QLELE-EVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1071
+ E E H++ R++ V T ++ DH + LL++
Sbjct: 2130 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2175
Score = 135 bits (339), Expect = 3e-31
Identities = 238/962 (24%), Positives = 398/962 (41%), Gaps = 146/962 (15%)
Query: 245 GGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQ 304
GG+ G + EEAE Q + ++R + + QR+ L ++A+ E
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1496
Query: 305 RQRSGE-GTLLDLHQQKEAARRKARE---EKARQ-------ARRAAIQELQQKRALRAQK 353
R++ L +L Q E A R+ R+ E+ARQ A+R+A ELQ KRA A+K
Sbjct: 1497 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1556
Query: 354 ASTAERGPPE---------NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAA 404
+ ER E E R + + LKAN A
Sbjct: 1557 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1616
Query: 405 GPGDRCLPTSDSSPEPQQPPEDR---------TQDVLAQDAAGDNLEMMAP-SRGSAKSR 454
+ + + E Q+ +R Q V ++ A LE + G+A+ R
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1676
Query: 455 GPLEELLHTL-----------QLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLE 503
E+ L L QLLE+E R A ++ + L E
Sbjct: 1677 LAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAELAKVRAE 1731
Query: 504 KFGKLSAFPEPPEDGTLLSEAKLQSIMS----FLDEMEKSGQ-----DQLDSQQEGWVPE 554
L++ E+ SE Q + + F + E++ + ++ Q++ +
Sbjct: 1732 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1791
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
A E ++ + + K +A + L+ A+ L RR+ E E R+L+
Sbjct: 1792 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLE 1849
Query: 615 RQREHYEATIQRHLAFI----DQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQ 667
Q ++A I+ LA + D +E +K L E ++++E + E+ A +
Sbjct: 1850 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1909
Query: 668 AQHELEIKKLK----ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
A+ ELE+ +++ + + + E+A E + +E R E +QK +A ++
Sbjct: 1910 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1969
Query: 724 RRLK-SLHEAELLQSD--------ERASQRCLRQ------AEELREQLEREKEALGQQER 768
R+ K +L E E L++ ERA Q RQ A + R Q E + A Q++
Sbjct: 1970 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029
Query: 769 ERARQRFQQHLEQEQWALQQQR-----QRLYSEVAEE----RERLGQQAARQRAELEELR 819
E Q QQ L+QEQ L Q R R +E AEE ER Q+ RQ E E L+
Sbjct: 2030 E---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2086
Query: 820 QQLEESSSALTRALRAEFEKGREEQE----RRHQMELNTLKQQ----LELERQAWEAGRT 871
Q EE + A +A +A EK R+E E RR Q E L+Q+ E+E+ A +T
Sbjct: 2087 QSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2145
Query: 872 RKEEAWLLNREQELREEIRKGRDKE--IELVIHRLEADMALAKEESEKAAE--------- 920
+++A + LR ++ + ++ ++ + RL+A+ A + + E
Sbjct: 2146 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2205
Query: 921 SRIKRLRDKYEAE-----LSELEQSERKLQERCSELK------GQLGEAEGENLRLQGLV 969
+ +L+ + EAE L + + ++R LQE ++K +L A E RL+ L
Sbjct: 2206 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2265
Query: 970 RQ---KERAL------EDAQAVNE--QLSSERSNLAQ--VIRQEFEDRLAASEEETRQAK 1016
+ ++RAL E QAV E +L +E L Q + QE RL +E+ Q
Sbjct: 2266 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2325
Query: 1017 AE-----LATLQA--RQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELL 1069
AE TL+A ++QLE+ R+K +A A + + K+A+ + E L
Sbjct: 2326 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2385
Query: 1070 EQ 1071
+
Sbjct: 2386 HR 2387
Score = 129 bits (325), Expect = 1e-29
Identities = 220/871 (25%), Positives = 371/871 (42%), Gaps = 121/871 (13%)
Query: 252 RRKEVTEEEAERFIHQVNQATV--TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
+ K+ E EA RF +A + + Q Q AAR + E+ G
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1811
Query: 310 EGTLLDLH-----QQKEAARRKAR---EEKARQARRAAIQELQQK-----RALRAQKAST 356
E T L ++KEA + R E++A Q RR Q Q K R + +KAS
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871
Query: 357 AERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS 416
+E + E + RQ +E+ ALKA+ AAG + L
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEIL---------ALKASFEKA---AAGKAELELELGRI 1919
Query: 417 SPEPQQPPEDRTQDVLA-----QDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q L Q AA + KS EE + +E
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ L + + R +E++ A L +L A + E +LQ +
Sbjct: 1980 ERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL- 2037
Query: 532 FLDEMEKSGQDQLDSQQEGW---VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ 588
+ E+S DQL + E EA ++ E + S +++ E E KQ+
Sbjct: 2038 ---QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2093
Query: 589 RALAQQRDLTARRVKETEKALSRQLQ------RQREHYEATIQRHLAFIDQLIEDKKVLS 642
+A AQ + + KE E+ +R+ Q RQ++ +A +++H F +Q + K +
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2153
Query: 643 EKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKE 702
++ + +L++ D + + + E+++LK ATE AR+ + E+
Sbjct: 2154 QELTTLRLQLEETDHQ--------KNLLDEELQRLKA--EATEAARQRSQVEEEL----- 2198
Query: 703 VTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEA 762
+VR E+ KL AR + E R L + D+ +QR L++ E +Q+ E
Sbjct: 2199 FSVRVQMEELSKLKARIEAENRAL--------ILRDKDNTQRFLQEEAEKMKQVAEEAAR 2250
Query: 763 LGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQL 822
L +E AR R L +E A Q++ L ++ +E+ + Q+A R +AE E L+QQ
Sbjct: 2251 LSVAAQEAARLR---QLAEEDLA---QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2304
Query: 823 EESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQ-----AWEAGRTRKEEAW 877
E + R ++ +E+ ++ E ++ LE ERQ + EA R + A
Sbjct: 2305 ELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2359
Query: 878 LLNREQELREEIRKGRDK--EIELVIHRLEADMALAKEESEKAAES-RIKRLRDKYEAE- 933
+ + E+ ++ R + EI +HR E LA +E ++ I+R + ++AE
Sbjct: 2360 MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAER 2415
Query: 934 ----LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSE 989
++ELE+ + KLQ+ L QL E + + Q+E+ L++ QA+ + SE
Sbjct: 2416 LREAIAELEREKEKLQQEAKLL--QLKSEEMQTV-------QQEQLLQETQALQQSFLSE 2466
Query: 990 RSNLAQVIRQEFEDRLAASEEETRQ---AKAE-LATLQARQQLELEEVHRRVKTALARKE 1045
+ +L Q R+ F ++ A E+ Q AKA+ L Q RQQ ++E+ +R+ +A E
Sbjct: 2467 KDSLLQ--RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASME 2521
Query: 1046 EAVSSLRTQHEA--AVKRADHLEELLEQHRR 1074
EA R QHEA V+R + LEQ RR
Sbjct: 2522 EA---RRRQHEAEEGVRRKQEELQQLEQQRR 2549
Score = 108 bits (269), Expect = 4e-23
Identities = 194/856 (22%), Positives = 346/856 (40%), Gaps = 105/856 (12%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG 287
++ K++++ +AR + R K EE A R + Q + + + Q+R
Sbjct: 1957 RVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERAEQESARQLQLAQEAAQKRL 2015
Query: 288 AGAARLEHLLQAKREEQRQRS--GEGTLLD-LHQQKEAARRKARE-EKAR-QARRAAIQE 342
+ ++E++ Q++ E ++LD L + EAARR A E E+AR QA R A Q
Sbjct: 2016 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2075
Query: 343 LQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLP 402
+Q K S E+ + +R+ A++ + AL+
Sbjct: 2076 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA----- 2130
Query: 403 AAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLH 462
+D+ E + ++T AQ + R LEE H
Sbjct: 2131 -----------ADAEMEKHKKFAEQTLRQKAQ-----------VEQELTTLRLQLEETDH 2168
Query: 463 TLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS 522
LL++E L T + + EE + + +E+ KL A E +L
Sbjct: 2169 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV---QMEELSKLKARIEAENRALILR 2225
Query: 523 EAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQ 582
+ D ++ Q++ + ++ V+ RL + +E +
Sbjct: 2226 DK---------DNTQRFLQEEAEKMKQ----------------VAEEAARLSVAAQEAAR 2260
Query: 583 AMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFID--QLIEDKKV 640
L + LAQQR L + +KE +A+ + + E Q+ LA +L EDK+
Sbjct: 2261 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2320
Query: 641 LSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKI 700
++++ +AE Q QR E Q Q + E ++LK + E +R + E ++
Sbjct: 2321 MAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLK--LRVAEMSRAQARAEEDAQRF 2374
Query: 701 KEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELRE---QLE 757
++ E +KL H+ E L + + L+Q+ E Q+ AE LRE +LE
Sbjct: 2375 RKQA----EEIGEKL---HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2424
Query: 758 REKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEE 817
REKE L QQE + + + ++ +Q L Q+ Q L E++ L Q+ E +
Sbjct: 2425 REKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2483
Query: 818 LRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAW 877
L +QL + A + LR E ++ +++ E+ Q + ++++ + +A E R ++EE
Sbjct: 2484 L-EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2542
Query: 878 LLNREQELREEIRKGRDKEIELVIHRLEAD--MALAKEE----SEKAAESRIKRLRDKYE 931
L +++ +EE+ ++ + + LE ALA E S+ AA + RD +
Sbjct: 2543 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2602
Query: 932 AELSELEQS------ERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQ 985
+E E RK+ + + G L E + L QG E L + V
Sbjct: 2603 GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL-AQGHTTVDE--LARREDVRHY 2659
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAE-----LATLQARQQLELEEVHRRVKTA 1040
L RS++A ++ + ++L+ RQ + L QA L+ V R T
Sbjct: 2660 LQG-RSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTV 2718
Query: 1041 LARKEEAVSSLRTQHE 1056
+E V H+
Sbjct: 2719 NEAVKEGVVGPELHHK 2734
Score = 95.1 bits (235), Expect = 3e-19
Identities = 174/693 (25%), Positives = 293/693 (42%), Gaps = 109/693 (15%)
Query: 418 PEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRP 477
P ++P + Q + Q A +E + +G A+ E++L P+ P
Sbjct: 978 PLDKEPARECAQRIAEQQKAQAEVEGLG--KGVARLSAEAEKVLAL-------PEPSPAA 1028
Query: 478 RTHHRGRYAWASEEDDASSLTADNLEKFGKLSAF---PEPPEDGTLLSEAKL---QSIMS 531
T + + SL+A LEK +S + E+ E +L Q++ +
Sbjct: 1029 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1088
Query: 532 FLDEME--KSGQDQLDSQQEGWVPEAGP------GPLELGSEVSTSVMRLKLEVEE-KKQ 582
L E+E K+ +L +Q E P G E+G + +EVE +++
Sbjct: 1089 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1148
Query: 583 AMLLLQR--ALAQQRDLTARRVKETEKALSRQLQRQREHYE---ATIQRHLAFIDQL--- 634
LL+R A+ Q D+ R +++ L RQL+ RE + A +Q +Q+
Sbjct: 1149 VAQLLERWQAVLAQTDVRQRELEQ----LGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1204
Query: 635 -IEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLK--ELMSATEKARREK 691
+ D + + E+ A L +E +R E+V + Q + I +K EL T KA+ E
Sbjct: 1205 PLADSQAVREQLRQEQA-LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1263
Query: 692 WISEKTKKIKEVTVRGLEPEIQKLI--ARHKQEVRRLKSLHEAELLQSDERASQRCLRQA 749
++ KK K + G E IQ+ + H E+ L S + + ++ LR+
Sbjct: 1264 -VASPAKKPKVQS--GSESVIQEYVDLRTHYSELTTLTSQYIKFISET--------LRRM 1312
Query: 750 EELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAA 809
EE +E L +Q+R R+R L + + AL++QRQ +AE + QA
Sbjct: 1313 EE--------EERLAEQQRAEERER----LAEVEAALEKQRQ-----LAEAHAQAKAQAE 1355
Query: 810 RQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELE-----RQ 864
R E +EL+Q+++E R E ++Q+R Q EL L+Q E E RQ
Sbjct: 1356 R---EAKELQQRMQEEV-----VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1407
Query: 865 AWEAGRTR---KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES 921
A A R+R +EE ++ + E E R G + E++ + R E A ++ E+A
Sbjct: 1408 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA--- 1464
Query: 922 RIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQA 981
+RLR + + E Q+E +L R EAE R+K+RAL+ +
Sbjct: 1465 --ERLRRQVQDESQRKRQAEVELASRVK------AEAEA--------AREKQRALQALEE 1508
Query: 982 VNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTAL 1041
+ Q L Q + A E R A+AEL + +A E +++ +L
Sbjct: 1509 LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA----SFAEKTAQLERSL 1564
Query: 1042 ARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 1074
+ AV+ LR + E ++ E E+ R
Sbjct: 1565 QEEHVAVAQLREEAERRAQQQAEAERAREEAER 1597
Score = 81.3 bits (199), Expect = 5e-15
Identities = 124/568 (21%), Positives = 251/568 (44%), Gaps = 71/568 (12%)
Query: 552 VPEAGPGPLELGSEVSTSVMRLK-------LEVEEKKQAMLLLQRALAQQRDLTAR--RV 602
+PE P L SE+ ++ +L+ + +E+ K L+++ + L A ++
Sbjct: 1021 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1080
Query: 603 KETE---------KALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELK 653
KE + +A L++ R EA A D+L ++V E+ + E
Sbjct: 1081 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV-GERLQQRHGERD 1139
Query: 654 QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARRE-KWISEKTKKIKEVTVRGLEPEI 712
E +R ERVAQ +++ + +++ T+ +RE + + + + +E +P
Sbjct: 1140 VEVERWRERVAQL-------LERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADP-- 1186
Query: 713 QKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERAR 772
+ Q+ RR + +A L +D +A + LRQ + L E++ER E + +E +R
Sbjct: 1187 ---LGAWLQDARRRQEQIQAMPL-ADSQAVREQLRQEQALLEEIERHGEKV--EECQRFA 1240
Query: 773 QRFQQHLEQEQWAL---QQQRQRLYSEVAEERERLGQQAARQR--------AELEELRQQ 821
+++ ++ + L + Q + + S + + + G ++ Q +EL L Q
Sbjct: 1241 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1300
Query: 822 LEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNR 881
+ S R + E E+ E+Q + L ++ LE +RQ EA K +A
Sbjct: 1301 YIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA----- 1354
Query: 882 EQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAEL------- 934
E+E +E ++ +++ V+ R EA A+ ++ +++ + +++LR EAE+
Sbjct: 1355 EREAKELQQRMQEE----VVRREEA--AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1408
Query: 935 SELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLA 994
E+S +++E ++ QL E + +G ++ E+A+A Q E L
Sbjct: 1409 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1468
Query: 995 QVIRQEFEDRLAASEEETRQAKAELATLQARQQL--ELEEVHRRVKTALARKEEAVSSLR 1052
+ ++ E + + A E + KAE + +Q+ LEE+ + + A R +A
Sbjct: 1469 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1528
Query: 1053 TQHEAAVKRADHLEELLEQHRRPTPSTK 1080
Q + A++ A E Q +R + + K
Sbjct: 1529 RQVQVALETAQRSAEAELQSKRASFAEK 1556
Score = 57.4 bits (137), Expect = 7e-08
Identities = 95/384 (24%), Positives = 157/384 (40%), Gaps = 62/384 (16%)
Query: 728 SLHEAELLQS------DERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQ 781
S H +LLQS +E QRC+ + +++R QLE + R R + L++
Sbjct: 930 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE--------TRTVHRLRLPLDK 981
Query: 782 EQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGR 841
E QR + E E LG+ AR AE E++ E S +A T E G+
Sbjct: 982 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1041
Query: 842 EEQERR----HQMELNTLKQQLELERQAWEAGRTRKEE--------AWLLNRE------- 882
EQ R + +L T+ + + A E R +E+ A L E
Sbjct: 1042 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1101
Query: 883 -------------QELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDK 929
LR+E+R ++ V RL+ E E+ E R+ +L ++
Sbjct: 1102 KLRAQAEAQQPTFDALRDELRGAQE-----VGERLQQRHGERDVEVERWRE-RVAQLLER 1155
Query: 930 YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKER----ALEDAQAVNEQ 985
++A L++ + +R+L++ +L+ A+ LQ R++E+ L D+QAV EQ
Sbjct: 1156 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1215
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ-QLELEEVHRRVKTALARK 1044
L E Q + +E E EE R AK + ++ + QL + + A+K
Sbjct: 1216 LRQE-----QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1270
Query: 1045 EEAVSSLRTQHEAAVKRADHLEEL 1068
+ S + + V H EL
Sbjct: 1271 PKVQSGSESVIQEYVDLRTHYSEL 1294
Score = 39.7 bits (91), Expect = 0.016
Identities = 96/429 (22%), Positives = 180/429 (41%), Gaps = 71/429 (16%)
Query: 627 HLAFIDQLIEDKKVLSE----KC-EAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELM 681
H+A +++ +K++ SE +C + +V +L+ E C E++ QA A + +++ L+
Sbjct: 342 HVAILER---EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR----LL 394
Query: 682 SATEKARREKWISEKTKKIKEVTVRGLEPEIQKLI-ARH---KQEVRRLKSLHEAELLQS 737
+A + +R + K + +R L ++Q L RH +Q RR+ LHE +
Sbjct: 395 AAGKVPQRAGEVERDLDKADSM-IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR 453
Query: 738 DERASQRCLRQAEELREQLEREKEALGQQ-ERERARQRFQQHLEQEQWALQQQRQRLYSE 796
E + A + + +++ ++ E E + R+ Q L W + Q + +E
Sbjct: 454 TEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA--WVEENQHRVDGAE 511
Query: 797 VAEERERLGQQAARQRA---ELEELRQQLEESSS---ALTRALRAEFEKGREEQERRHQM 850
+ + Q R +EE R ++E + S L+ A R + + ++
Sbjct: 512 WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 571
Query: 851 ELNTLKQQLE-LERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMA 909
LN+ K +L LE KE WL +E+E E D+ + + E+ A
Sbjct: 572 LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE--EVGFDWSDRNTNMTAKK-ESYSA 628
Query: 910 LAKEESEKAAESRIKRLRDKYEAELSE-------LEQSERKLQERCS------------- 949
L +E K E +IK L++ + L E +E + LQ + S
Sbjct: 629 LMRELELK--EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 686
Query: 950 -------ELKGQLGEAEGENLRLQGLVRQK------------ERALEDAQAVNEQLSSER 990
+ + EAEG+ +LQ +R+K E L+DAQ EQL+ +
Sbjct: 687 KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 746
Query: 991 SNLAQVIRQ 999
+L+ + ++
Sbjct: 747 GHLSGLAKR 755
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 150 bits (380), Expect = 5e-36
Identities = 209/886 (23%), Positives = 356/886 (40%), Gaps = 131/886 (14%)
Query: 280 RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA 339
R ++ A + L +A + + Q E L Q+E RR+ A+Q +R+
Sbjct: 1496 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1555
Query: 340 IQELQQKRA-------LRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL 392
+ELQQ R +A++A AER E RV ++ A E QAL
Sbjct: 1556 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1615
Query: 393 KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK 452
+A R + Q+ E + V + E+ SR A+
Sbjct: 1616 RA--------------RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1661
Query: 453 SRGPLE-----ELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGK 507
+ E + L L+L +E + R R R + E S A E K
Sbjct: 1662 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA---ELQSK 1718
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
++F E + + ++ +E E+ Q Q ++++ E LE +
Sbjct: 1719 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER---AREEAERELERWQLKA 1775
Query: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA----------LSRQLQRQR 617
+RL+L+ EE Q L Q +Q++ R + KA ++L++QR
Sbjct: 1776 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1835
Query: 618 EHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKL 677
+ E T Q+ LA +LI + A + +Q+ Q E +A+ Q + +K
Sbjct: 1836 QLAEGTAQQRLAAEQELI--------RLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1887
Query: 678 KELMSATEKARREKWI--------SEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSL 729
+EL + K R E + E+++ E + + LE E + +E RL++L
Sbjct: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARLRAL 1946
Query: 730 HEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQ 789
E E + + A + RQ E L + A+G+ R + +E+ A ++
Sbjct: 1947 AE-EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL---KEKEAENER 2002
Query: 790 RQRLYSEVAEERERLGQQAARQRAELEELRQQLEESS-SALTR----------------- 831
+RL + A +R RL +QAA+ +A++EE QL ++S S L R
Sbjct: 2003 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 2062
Query: 832 ---ALRAEFEK---GREEQERRHQMELNTLKQQLE-----LERQAWEAGRTRKEEAWLLN 880
AL+A FEK G+ E E +EL ++ E E+ EA R R+ A
Sbjct: 2063 EILALKASFEKAAAGKAELE----LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 2118
Query: 881 REQELREEIRKGRDKEIELV---------IHRLEADMALAKEESEKAA-----------E 920
R +E E ++K E E + RL+A + A+ E+A E
Sbjct: 2119 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2178
Query: 921 SRIKRLRDKYEAELSELEQSERKLQERCSELKGQL----GEAEG--------ENLRLQGL 968
+ KRL+ + +A ++Q E++LQ+ + + L GEAE E R+Q
Sbjct: 2179 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2238
Query: 969 --VRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ 1026
Q R +E+A+ + + + AQ + R A +E R+A+AE A L+ +Q
Sbjct: 2239 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ 2298
Query: 1027 QLELE-EVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1071
+ E E H++ R++ V T ++ DH + LL++
Sbjct: 2299 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2344
Score = 135 bits (339), Expect = 3e-31
Identities = 238/962 (24%), Positives = 398/962 (41%), Gaps = 146/962 (15%)
Query: 245 GGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQ 304
GG+ G + EEAE Q + ++R + + QR+ L ++A+ E
Sbjct: 1606 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1665
Query: 305 RQRSGE-GTLLDLHQQKEAARRKARE---EKARQ-------ARRAAIQELQQKRALRAQK 353
R++ L +L Q E A R+ R+ E+ARQ A+R+A ELQ KRA A+K
Sbjct: 1666 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1725
Query: 354 ASTAERGPPE---------NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAA 404
+ ER E E R + + LKAN A
Sbjct: 1726 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1785
Query: 405 GPGDRCLPTSDSSPEPQQPPEDR---------TQDVLAQDAAGDNLEMMAP-SRGSAKSR 454
+ + + E Q+ +R Q V ++ A LE + G+A+ R
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1845
Query: 455 GPLEELLHTL-----------QLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLE 503
E+ L L QLLE+E R A ++ + L E
Sbjct: 1846 LAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAELAKVRAE 1900
Query: 504 KFGKLSAFPEPPEDGTLLSEAKLQSIMS----FLDEMEKSGQ-----DQLDSQQEGWVPE 554
L++ E+ SE Q + + F + E++ + ++ Q++ +
Sbjct: 1901 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1960
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
A E ++ + + K +A + L+ A+ L RR+ E E R+L+
Sbjct: 1961 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLE 2018
Query: 615 RQREHYEATIQRHLAFI----DQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQ 667
Q ++A I+ LA + D +E +K L E ++++E + E+ A +
Sbjct: 2019 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 2078
Query: 668 AQHELEIKKLK----ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
A+ ELE+ +++ + + + E+A E + +E R E +QK +A ++
Sbjct: 2079 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2138
Query: 724 RRLK-SLHEAELLQSD--------ERASQRCLRQ------AEELREQLEREKEALGQQER 768
R+ K +L E E L++ ERA Q RQ A + R Q E + A Q++
Sbjct: 2139 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2198
Query: 769 ERARQRFQQHLEQEQWALQQQR-----QRLYSEVAEE----RERLGQQAARQRAELEELR 819
E Q QQ L+QEQ L Q R R +E AEE ER Q+ RQ E E L+
Sbjct: 2199 E---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2255
Query: 820 QQLEESSSALTRALRAEFEKGREEQE----RRHQMELNTLKQQ----LELERQAWEAGRT 871
Q EE + A +A +A EK R+E E RR Q E L+Q+ E+E+ A +T
Sbjct: 2256 QSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2314
Query: 872 RKEEAWLLNREQELREEIRKGRDKE--IELVIHRLEADMALAKEESEKAAE--------- 920
+++A + LR ++ + ++ ++ + RL+A+ A + + E
Sbjct: 2315 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2374
Query: 921 SRIKRLRDKYEAE-----LSELEQSERKLQERCSELK------GQLGEAEGENLRLQGLV 969
+ +L+ + EAE L + + ++R LQE ++K +L A E RL+ L
Sbjct: 2375 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2434
Query: 970 RQ---KERAL------EDAQAVNE--QLSSERSNLAQ--VIRQEFEDRLAASEEETRQAK 1016
+ ++RAL E QAV E +L +E L Q + QE RL +E+ Q
Sbjct: 2435 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2494
Query: 1017 AE-----LATLQA--RQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELL 1069
AE TL+A ++QLE+ R+K +A A + + K+A+ + E L
Sbjct: 2495 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2554
Query: 1070 EQ 1071
+
Sbjct: 2555 HR 2556
Score = 129 bits (325), Expect = 1e-29
Identities = 220/871 (25%), Positives = 371/871 (42%), Gaps = 121/871 (13%)
Query: 252 RRKEVTEEEAERFIHQVNQATV--TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
+ K+ E EA RF +A + + Q Q AAR + E+ G
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980
Query: 310 EGTLLDLH-----QQKEAARRKAR---EEKARQARRAAIQELQQK-----RALRAQKAST 356
E T L ++KEA + R E++A Q RR Q Q K R + +KAS
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040
Query: 357 AERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS 416
+E + E + RQ +E+ ALKA+ AAG + L
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEIL---------ALKASFEKA---AAGKAELELELGRI 2088
Query: 417 SPEPQQPPEDRTQDVLA-----QDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q L Q AA + KS EE + +E
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ L + + R +E++ A L +L A + E +LQ +
Sbjct: 2149 ERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL- 2206
Query: 532 FLDEMEKSGQDQLDSQQEGW---VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ 588
+ E+S DQL + E EA ++ E + S +++ E E KQ+
Sbjct: 2207 ---QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2262
Query: 589 RALAQQRDLTARRVKETEKALSRQLQ------RQREHYEATIQRHLAFIDQLIEDKKVLS 642
+A AQ + + KE E+ +R+ Q RQ++ +A +++H F +Q + K +
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2322
Query: 643 EKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKE 702
++ + +L++ D + + + E+++LK ATE AR+ + E+
Sbjct: 2323 QELTTLRLQLEETDHQ--------KNLLDEELQRLKA--EATEAARQRSQVEEEL----- 2367
Query: 703 VTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEA 762
+VR E+ KL AR + E R L + D+ +QR L++ E +Q+ E
Sbjct: 2368 FSVRVQMEELSKLKARIEAENRAL--------ILRDKDNTQRFLQEEAEKMKQVAEEAAR 2419
Query: 763 LGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQL 822
L +E AR R L +E A Q++ L ++ +E+ + Q+A R +AE E L+QQ
Sbjct: 2420 LSVAAQEAARLR---QLAEEDLA---QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2473
Query: 823 EESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQ-----AWEAGRTRKEEAW 877
E + R ++ +E+ ++ E ++ LE ERQ + EA R + A
Sbjct: 2474 ELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2528
Query: 878 LLNREQELREEIRKGRDK--EIELVIHRLEADMALAKEESEKAAES-RIKRLRDKYEAE- 933
+ + E+ ++ R + EI +HR E LA +E ++ I+R + ++AE
Sbjct: 2529 MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAER 2584
Query: 934 ----LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSE 989
++ELE+ + KLQ+ L QL E + + Q+E+ L++ QA+ + SE
Sbjct: 2585 LREAIAELEREKEKLQQEAKLL--QLKSEEMQTV-------QQEQLLQETQALQQSFLSE 2635
Query: 990 RSNLAQVIRQEFEDRLAASEEETRQ---AKAE-LATLQARQQLELEEVHRRVKTALARKE 1045
+ +L Q R+ F ++ A E+ Q AKA+ L Q RQQ ++E+ +R+ +A E
Sbjct: 2636 KDSLLQ--RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASME 2690
Query: 1046 EAVSSLRTQHEA--AVKRADHLEELLEQHRR 1074
EA R QHEA V+R + LEQ RR
Sbjct: 2691 EA---RRRQHEAEEGVRRKQEELQQLEQQRR 2718
Score = 108 bits (269), Expect = 4e-23
Identities = 194/856 (22%), Positives = 346/856 (40%), Gaps = 105/856 (12%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG 287
++ K++++ +AR + R K EE A R + Q + + + Q+R
Sbjct: 2126 RVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERAEQESARQLQLAQEAAQKRL 2184
Query: 288 AGAARLEHLLQAKREEQRQRS--GEGTLLD-LHQQKEAARRKARE-EKAR-QARRAAIQE 342
+ ++E++ Q++ E ++LD L + EAARR A E E+AR QA R A Q
Sbjct: 2185 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2244
Query: 343 LQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLP 402
+Q K S E+ + +R+ A++ + AL+
Sbjct: 2245 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA----- 2299
Query: 403 AAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLH 462
+D+ E + ++T AQ + R LEE H
Sbjct: 2300 -----------ADAEMEKHKKFAEQTLRQKAQ-----------VEQELTTLRLQLEETDH 2337
Query: 463 TLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS 522
LL++E L T + + EE + + +E+ KL A E +L
Sbjct: 2338 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV---QMEELSKLKARIEAENRALILR 2394
Query: 523 EAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQ 582
+ D ++ Q++ + ++ V+ RL + +E +
Sbjct: 2395 DK---------DNTQRFLQEEAEKMKQ----------------VAEEAARLSVAAQEAAR 2429
Query: 583 AMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFID--QLIEDKKV 640
L + LAQQR L + +KE +A+ + + E Q+ LA +L EDK+
Sbjct: 2430 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2489
Query: 641 LSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKI 700
++++ +AE Q QR E Q Q + E ++LK + E +R + E ++
Sbjct: 2490 MAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLK--LRVAEMSRAQARAEEDAQRF 2543
Query: 701 KEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELRE---QLE 757
++ E +KL H+ E L + + L+Q+ E Q+ AE LRE +LE
Sbjct: 2544 RKQA----EEIGEKL---HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593
Query: 758 REKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEE 817
REKE L QQE + + + ++ +Q L Q+ Q L E++ L Q+ E +
Sbjct: 2594 REKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2652
Query: 818 LRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAW 877
L +QL + A + LR E ++ +++ E+ Q + ++++ + +A E R ++EE
Sbjct: 2653 L-EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2711
Query: 878 LLNREQELREEIRKGRDKEIELVIHRLEAD--MALAKEE----SEKAAESRIKRLRDKYE 931
L +++ +EE+ ++ + + LE ALA E S+ AA + RD +
Sbjct: 2712 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2771
Query: 932 AELSELEQS------ERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQ 985
+E E RK+ + + G L E + L QG E L + V
Sbjct: 2772 GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL-AQGHTTVDE--LARREDVRHY 2828
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAE-----LATLQARQQLELEEVHRRVKTA 1040
L RS++A ++ + ++L+ RQ + L QA L+ V R T
Sbjct: 2829 LQG-RSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTV 2887
Query: 1041 LARKEEAVSSLRTQHE 1056
+E V H+
Sbjct: 2888 NEAVKEGVVGPELHHK 2903
Score = 95.1 bits (235), Expect = 3e-19
Identities = 174/693 (25%), Positives = 293/693 (42%), Gaps = 109/693 (15%)
Query: 418 PEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRP 477
P ++P + Q + Q A +E + +G A+ E++L P+ P
Sbjct: 1147 PLDKEPARECAQRIAEQQKAQAEVEGLG--KGVARLSAEAEKVLAL-------PEPSPAA 1197
Query: 478 RTHHRGRYAWASEEDDASSLTADNLEKFGKLSAF---PEPPEDGTLLSEAKL---QSIMS 531
T + + SL+A LEK +S + E+ E +L Q++ +
Sbjct: 1198 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1257
Query: 532 FLDEME--KSGQDQLDSQQEGWVPEAGP------GPLELGSEVSTSVMRLKLEVEE-KKQ 582
L E+E K+ +L +Q E P G E+G + +EVE +++
Sbjct: 1258 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1317
Query: 583 AMLLLQR--ALAQQRDLTARRVKETEKALSRQLQRQREHYE---ATIQRHLAFIDQL--- 634
LL+R A+ Q D+ R +++ L RQL+ RE + A +Q +Q+
Sbjct: 1318 VAQLLERWQAVLAQTDVRQRELEQ----LGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1373
Query: 635 -IEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLK--ELMSATEKARREK 691
+ D + + E+ A L +E +R E+V + Q + I +K EL T KA+ E
Sbjct: 1374 PLADSQAVREQLRQEQA-LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1432
Query: 692 WISEKTKKIKEVTVRGLEPEIQKLI--ARHKQEVRRLKSLHEAELLQSDERASQRCLRQA 749
++ KK K + G E IQ+ + H E+ L S + + ++ LR+
Sbjct: 1433 -VASPAKKPKVQS--GSESVIQEYVDLRTHYSELTTLTSQYIKFISET--------LRRM 1481
Query: 750 EELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAA 809
EE +E L +Q+R R+R L + + AL++QRQ +AE + QA
Sbjct: 1482 EE--------EERLAEQQRAEERER----LAEVEAALEKQRQ-----LAEAHAQAKAQAE 1524
Query: 810 RQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELE-----RQ 864
R E +EL+Q+++E R E ++Q+R Q EL L+Q E E RQ
Sbjct: 1525 R---EAKELQQRMQEEV-----VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1576
Query: 865 AWEAGRTR---KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES 921
A A R+R +EE ++ + E E R G + E++ + R E A ++ E+A
Sbjct: 1577 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA--- 1633
Query: 922 RIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQA 981
+RLR + + E Q+E +L R EAE R+K+RAL+ +
Sbjct: 1634 --ERLRRQVQDESQRKRQAEVELASRVK------AEAEA--------AREKQRALQALEE 1677
Query: 982 VNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTAL 1041
+ Q L Q + A E R A+AEL + +A E +++ +L
Sbjct: 1678 LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA----SFAEKTAQLERSL 1733
Query: 1042 ARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 1074
+ AV+ LR + E ++ E E+ R
Sbjct: 1734 QEEHVAVAQLREEAERRAQQQAEAERAREEAER 1766
Score = 81.3 bits (199), Expect = 5e-15
Identities = 124/568 (21%), Positives = 251/568 (44%), Gaps = 71/568 (12%)
Query: 552 VPEAGPGPLELGSEVSTSVMRLK-------LEVEEKKQAMLLLQRALAQQRDLTAR--RV 602
+PE P L SE+ ++ +L+ + +E+ K L+++ + L A ++
Sbjct: 1190 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1249
Query: 603 KETE---------KALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELK 653
KE + +A L++ R EA A D+L ++V E+ + E
Sbjct: 1250 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV-GERLQQRHGERD 1308
Query: 654 QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARRE-KWISEKTKKIKEVTVRGLEPEI 712
E +R ERVAQ +++ + +++ T+ +RE + + + + +E +P
Sbjct: 1309 VEVERWRERVAQL-------LERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADP-- 1355
Query: 713 QKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERAR 772
+ Q+ RR + +A L +D +A + LRQ + L E++ER E + +E +R
Sbjct: 1356 ---LGAWLQDARRRQEQIQAMPL-ADSQAVREQLRQEQALLEEIERHGEKV--EECQRFA 1409
Query: 773 QRFQQHLEQEQWAL---QQQRQRLYSEVAEERERLGQQAARQR--------AELEELRQQ 821
+++ ++ + L + Q + + S + + + G ++ Q +EL L Q
Sbjct: 1410 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1469
Query: 822 LEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNR 881
+ S R + E E+ E+Q + L ++ LE +RQ EA K +A
Sbjct: 1470 YIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA----- 1523
Query: 882 EQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAEL------- 934
E+E +E ++ +++ V+ R EA A+ ++ +++ + +++LR EAE+
Sbjct: 1524 EREAKELQQRMQEE----VVRREEA--AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1577
Query: 935 SELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLA 994
E+S +++E ++ QL E + +G ++ E+A+A Q E L
Sbjct: 1578 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1637
Query: 995 QVIRQEFEDRLAASEEETRQAKAELATLQARQQL--ELEEVHRRVKTALARKEEAVSSLR 1052
+ ++ E + + A E + KAE + +Q+ LEE+ + + A R +A
Sbjct: 1638 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1697
Query: 1053 TQHEAAVKRADHLEELLEQHRRPTPSTK 1080
Q + A++ A E Q +R + + K
Sbjct: 1698 RQVQVALETAQRSAEAELQSKRASFAEK 1725
Score = 57.4 bits (137), Expect = 7e-08
Identities = 95/384 (24%), Positives = 157/384 (40%), Gaps = 62/384 (16%)
Query: 728 SLHEAELLQS------DERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQ 781
S H +LLQS +E QRC+ + +++R QLE + R R + L++
Sbjct: 1099 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE--------TRTVHRLRLPLDK 1150
Query: 782 EQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGR 841
E QR + E E LG+ AR AE E++ E S +A T E G+
Sbjct: 1151 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1210
Query: 842 EEQERR----HQMELNTLKQQLELERQAWEAGRTRKEE--------AWLLNRE------- 882
EQ R + +L T+ + + A E R +E+ A L E
Sbjct: 1211 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1270
Query: 883 -------------QELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDK 929
LR+E+R ++ V RL+ E E+ E R+ +L ++
Sbjct: 1271 KLRAQAEAQQPTFDALRDELRGAQE-----VGERLQQRHGERDVEVERWRE-RVAQLLER 1324
Query: 930 YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKER----ALEDAQAVNEQ 985
++A L++ + +R+L++ +L+ A+ LQ R++E+ L D+QAV EQ
Sbjct: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1384
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ-QLELEEVHRRVKTALARK 1044
L E Q + +E E EE R AK + ++ + QL + + A+K
Sbjct: 1385 LRQE-----QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1439
Query: 1045 EEAVSSLRTQHEAAVKRADHLEEL 1068
+ S + + V H EL
Sbjct: 1440 PKVQSGSESVIQEYVDLRTHYSEL 1463
Score = 39.7 bits (91), Expect = 0.016
Identities = 96/429 (22%), Positives = 180/429 (41%), Gaps = 71/429 (16%)
Query: 627 HLAFIDQLIEDKKVLSE----KC-EAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELM 681
H+A +++ +K++ SE +C + +V +L+ E C E++ QA A + +++ L+
Sbjct: 511 HVAILER---EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR----LL 563
Query: 682 SATEKARREKWISEKTKKIKEVTVRGLEPEIQKLI-ARH---KQEVRRLKSLHEAELLQS 737
+A + +R + K + +R L ++Q L RH +Q RR+ LHE +
Sbjct: 564 AAGKVPQRAGEVERDLDKADSM-IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR 622
Query: 738 DERASQRCLRQAEELREQLEREKEALGQQ-ERERARQRFQQHLEQEQWALQQQRQRLYSE 796
E + A + + +++ ++ E E + R+ Q L W + Q + +E
Sbjct: 623 TEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA--WVEENQHRVDGAE 680
Query: 797 VAEERERLGQQAARQRA---ELEELRQQLEESSS---ALTRALRAEFEKGREEQERRHQM 850
+ + Q R +EE R ++E + S L+ A R + + ++
Sbjct: 681 WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 740
Query: 851 ELNTLKQQLE-LERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMA 909
LN+ K +L LE KE WL +E+E E D+ + + E+ A
Sbjct: 741 LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE--EVGFDWSDRNTNMTAKK-ESYSA 797
Query: 910 LAKEESEKAAESRIKRLRDKYEAELSE-------LEQSERKLQERCS------------- 949
L +E K E +IK L++ + L E +E + LQ + S
Sbjct: 798 LMRELELK--EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 855
Query: 950 -------ELKGQLGEAEGENLRLQGLVRQK------------ERALEDAQAVNEQLSSER 990
+ + EAEG+ +LQ +R+K E L+DAQ EQL+ +
Sbjct: 856 KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 915
Query: 991 SNLAQVIRQ 999
+L+ + ++
Sbjct: 916 GHLSGLAKR 924
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 150 bits (380), Expect = 5e-36
Identities = 209/886 (23%), Positives = 356/886 (40%), Gaps = 131/886 (14%)
Query: 280 RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA 339
R ++ A + L +A + + Q E L Q+E RR+ A+Q +R+
Sbjct: 1337 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1396
Query: 340 IQELQQKRA-------LRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL 392
+ELQQ R +A++A AER E RV ++ A E QAL
Sbjct: 1397 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1456
Query: 393 KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK 452
+A R + Q+ E + V + E+ SR A+
Sbjct: 1457 RA--------------RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1502
Query: 453 SRGPLE-----ELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGK 507
+ E + L L+L +E + R R R + E S A E K
Sbjct: 1503 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA---ELQSK 1559
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
++F E + + ++ +E E+ Q Q ++++ E LE +
Sbjct: 1560 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER---AREEAERELERWQLKA 1616
Query: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA----------LSRQLQRQR 617
+RL+L+ EE Q L Q +Q++ R + KA ++L++QR
Sbjct: 1617 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1676
Query: 618 EHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKL 677
+ E T Q+ LA +LI + A + +Q+ Q E +A+ Q + +K
Sbjct: 1677 QLAEGTAQQRLAAEQELI--------RLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728
Query: 678 KELMSATEKARREKWI--------SEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSL 729
+EL + K R E + E+++ E + + LE E + +E RL++L
Sbjct: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARLRAL 1787
Query: 730 HEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQ 789
E E + + A + RQ E L + A+G+ R + +E+ A ++
Sbjct: 1788 AE-EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL---KEKEAENER 1843
Query: 790 RQRLYSEVAEERERLGQQAARQRAELEELRQQLEESS-SALTR----------------- 831
+RL + A +R RL +QAA+ +A++EE QL ++S S L R
Sbjct: 1844 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1903
Query: 832 ---ALRAEFEK---GREEQERRHQMELNTLKQQLE-----LERQAWEAGRTRKEEAWLLN 880
AL+A FEK G+ E E +EL ++ E E+ EA R R+ A
Sbjct: 1904 EILALKASFEKAAAGKAELE----LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1959
Query: 881 REQELREEIRKGRDKEIELV---------IHRLEADMALAKEESEKAA-----------E 920
R +E E ++K E E + RL+A + A+ E+A E
Sbjct: 1960 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2019
Query: 921 SRIKRLRDKYEAELSELEQSERKLQERCSELKGQL----GEAEG--------ENLRLQGL 968
+ KRL+ + +A ++Q E++LQ+ + + L GEAE E R+Q
Sbjct: 2020 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2079
Query: 969 --VRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ 1026
Q R +E+A+ + + + AQ + R A +E R+A+AE A L+ +Q
Sbjct: 2080 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ 2139
Query: 1027 QLELE-EVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1071
+ E E H++ R++ V T ++ DH + LL++
Sbjct: 2140 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2185
Score = 135 bits (339), Expect = 3e-31
Identities = 238/962 (24%), Positives = 398/962 (41%), Gaps = 146/962 (15%)
Query: 245 GGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQ 304
GG+ G + EEAE Q + ++R + + QR+ L ++A+ E
Sbjct: 1447 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1506
Query: 305 RQRSGE-GTLLDLHQQKEAARRKARE---EKARQ-------ARRAAIQELQQKRALRAQK 353
R++ L +L Q E A R+ R+ E+ARQ A+R+A ELQ KRA A+K
Sbjct: 1507 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1566
Query: 354 ASTAERGPPE---------NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAA 404
+ ER E E R + + LKAN A
Sbjct: 1567 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1626
Query: 405 GPGDRCLPTSDSSPEPQQPPEDR---------TQDVLAQDAAGDNLEMMAP-SRGSAKSR 454
+ + + E Q+ +R Q V ++ A LE + G+A+ R
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1686
Query: 455 GPLEELLHTL-----------QLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLE 503
E+ L L QLLE+E R A ++ + L E
Sbjct: 1687 LAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAELAKVRAE 1741
Query: 504 KFGKLSAFPEPPEDGTLLSEAKLQSIMS----FLDEMEKSGQ-----DQLDSQQEGWVPE 554
L++ E+ SE Q + + F + E++ + ++ Q++ +
Sbjct: 1742 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1801
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
A E ++ + + K +A + L+ A+ L RR+ E E R+L+
Sbjct: 1802 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLE 1859
Query: 615 RQREHYEATIQRHLAFI----DQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQ 667
Q ++A I+ LA + D +E +K L E ++++E + E+ A +
Sbjct: 1860 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1919
Query: 668 AQHELEIKKLK----ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
A+ ELE+ +++ + + + E+A E + +E R E +QK +A ++
Sbjct: 1920 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1979
Query: 724 RRLK-SLHEAELLQSD--------ERASQRCLRQ------AEELREQLEREKEALGQQER 768
R+ K +L E E L++ ERA Q RQ A + R Q E + A Q++
Sbjct: 1980 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2039
Query: 769 ERARQRFQQHLEQEQWALQQQR-----QRLYSEVAEE----RERLGQQAARQRAELEELR 819
E Q QQ L+QEQ L Q R R +E AEE ER Q+ RQ E E L+
Sbjct: 2040 E---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2096
Query: 820 QQLEESSSALTRALRAEFEKGREEQE----RRHQMELNTLKQQ----LELERQAWEAGRT 871
Q EE + A +A +A EK R+E E RR Q E L+Q+ E+E+ A +T
Sbjct: 2097 QSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2155
Query: 872 RKEEAWLLNREQELREEIRKGRDKE--IELVIHRLEADMALAKEESEKAAE--------- 920
+++A + LR ++ + ++ ++ + RL+A+ A + + E
Sbjct: 2156 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2215
Query: 921 SRIKRLRDKYEAE-----LSELEQSERKLQERCSELK------GQLGEAEGENLRLQGLV 969
+ +L+ + EAE L + + ++R LQE ++K +L A E RL+ L
Sbjct: 2216 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2275
Query: 970 RQ---KERAL------EDAQAVNE--QLSSERSNLAQ--VIRQEFEDRLAASEEETRQAK 1016
+ ++RAL E QAV E +L +E L Q + QE RL +E+ Q
Sbjct: 2276 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2335
Query: 1017 AE-----LATLQA--RQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELL 1069
AE TL+A ++QLE+ R+K +A A + + K+A+ + E L
Sbjct: 2336 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2395
Query: 1070 EQ 1071
+
Sbjct: 2396 HR 2397
Score = 129 bits (325), Expect = 1e-29
Identities = 220/871 (25%), Positives = 371/871 (42%), Gaps = 121/871 (13%)
Query: 252 RRKEVTEEEAERFIHQVNQATV--TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
+ K+ E EA RF +A + + Q Q AAR + E+ G
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1821
Query: 310 EGTLLDLH-----QQKEAARRKAR---EEKARQARRAAIQELQQK-----RALRAQKAST 356
E T L ++KEA + R E++A Q RR Q Q K R + +KAS
Sbjct: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881
Query: 357 AERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS 416
+E + E + RQ +E+ ALKA+ AAG + L
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEIL---------ALKASFEKA---AAGKAELELELGRI 1929
Query: 417 SPEPQQPPEDRTQDVLA-----QDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q L Q AA + KS EE + +E
Sbjct: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ L + + R +E++ A L +L A + E +LQ +
Sbjct: 1990 ERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL- 2047
Query: 532 FLDEMEKSGQDQLDSQQEGW---VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ 588
+ E+S DQL + E EA ++ E + S +++ E E KQ+
Sbjct: 2048 ---QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2103
Query: 589 RALAQQRDLTARRVKETEKALSRQLQ------RQREHYEATIQRHLAFIDQLIEDKKVLS 642
+A AQ + + KE E+ +R+ Q RQ++ +A +++H F +Q + K +
Sbjct: 2104 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2163
Query: 643 EKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKE 702
++ + +L++ D + + + E+++LK ATE AR+ + E+
Sbjct: 2164 QELTTLRLQLEETDHQ--------KNLLDEELQRLKA--EATEAARQRSQVEEEL----- 2208
Query: 703 VTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEA 762
+VR E+ KL AR + E R L + D+ +QR L++ E +Q+ E
Sbjct: 2209 FSVRVQMEELSKLKARIEAENRAL--------ILRDKDNTQRFLQEEAEKMKQVAEEAAR 2260
Query: 763 LGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQL 822
L +E AR R L +E A Q++ L ++ +E+ + Q+A R +AE E L+QQ
Sbjct: 2261 LSVAAQEAARLR---QLAEEDLA---QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2314
Query: 823 EESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQ-----AWEAGRTRKEEAW 877
E + R ++ +E+ ++ E ++ LE ERQ + EA R + A
Sbjct: 2315 ELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2369
Query: 878 LLNREQELREEIRKGRDK--EIELVIHRLEADMALAKEESEKAAES-RIKRLRDKYEAE- 933
+ + E+ ++ R + EI +HR E LA +E ++ I+R + ++AE
Sbjct: 2370 MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAER 2425
Query: 934 ----LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSE 989
++ELE+ + KLQ+ L QL E + + Q+E+ L++ QA+ + SE
Sbjct: 2426 LREAIAELEREKEKLQQEAKLL--QLKSEEMQTV-------QQEQLLQETQALQQSFLSE 2476
Query: 990 RSNLAQVIRQEFEDRLAASEEETRQ---AKAE-LATLQARQQLELEEVHRRVKTALARKE 1045
+ +L Q R+ F ++ A E+ Q AKA+ L Q RQQ ++E+ +R+ +A E
Sbjct: 2477 KDSLLQ--RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASME 2531
Query: 1046 EAVSSLRTQHEA--AVKRADHLEELLEQHRR 1074
EA R QHEA V+R + LEQ RR
Sbjct: 2532 EA---RRRQHEAEEGVRRKQEELQQLEQQRR 2559
Score = 108 bits (269), Expect = 4e-23
Identities = 194/856 (22%), Positives = 346/856 (40%), Gaps = 105/856 (12%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG 287
++ K++++ +AR + R K EE A R + Q + + + Q+R
Sbjct: 1967 RVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERAEQESARQLQLAQEAAQKRL 2025
Query: 288 AGAARLEHLLQAKREEQRQRS--GEGTLLD-LHQQKEAARRKARE-EKAR-QARRAAIQE 342
+ ++E++ Q++ E ++LD L + EAARR A E E+AR QA R A Q
Sbjct: 2026 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2085
Query: 343 LQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLP 402
+Q K S E+ + +R+ A++ + AL+
Sbjct: 2086 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA----- 2140
Query: 403 AAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLH 462
+D+ E + ++T AQ + R LEE H
Sbjct: 2141 -----------ADAEMEKHKKFAEQTLRQKAQ-----------VEQELTTLRLQLEETDH 2178
Query: 463 TLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS 522
LL++E L T + + EE + + +E+ KL A E +L
Sbjct: 2179 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV---QMEELSKLKARIEAENRALILR 2235
Query: 523 EAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQ 582
+ D ++ Q++ + ++ V+ RL + +E +
Sbjct: 2236 DK---------DNTQRFLQEEAEKMKQ----------------VAEEAARLSVAAQEAAR 2270
Query: 583 AMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFID--QLIEDKKV 640
L + LAQQR L + +KE +A+ + + E Q+ LA +L EDK+
Sbjct: 2271 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2330
Query: 641 LSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKI 700
++++ +AE Q QR E Q Q + E ++LK + E +R + E ++
Sbjct: 2331 MAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLK--LRVAEMSRAQARAEEDAQRF 2384
Query: 701 KEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELRE---QLE 757
++ E +KL H+ E L + + L+Q+ E Q+ AE LRE +LE
Sbjct: 2385 RKQA----EEIGEKL---HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2434
Query: 758 REKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEE 817
REKE L QQE + + + ++ +Q L Q+ Q L E++ L Q+ E +
Sbjct: 2435 REKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2493
Query: 818 LRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAW 877
L +QL + A + LR E ++ +++ E+ Q + ++++ + +A E R ++EE
Sbjct: 2494 L-EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2552
Query: 878 LLNREQELREEIRKGRDKEIELVIHRLEAD--MALAKEE----SEKAAESRIKRLRDKYE 931
L +++ +EE+ ++ + + LE ALA E S+ AA + RD +
Sbjct: 2553 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2612
Query: 932 AELSELEQS------ERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQ 985
+E E RK+ + + G L E + L QG E L + V
Sbjct: 2613 GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL-AQGHTTVDE--LARREDVRHY 2669
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAE-----LATLQARQQLELEEVHRRVKTA 1040
L RS++A ++ + ++L+ RQ + L QA L+ V R T
Sbjct: 2670 LQG-RSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTV 2728
Query: 1041 LARKEEAVSSLRTQHE 1056
+E V H+
Sbjct: 2729 NEAVKEGVVGPELHHK 2744
Score = 95.1 bits (235), Expect = 3e-19
Identities = 174/693 (25%), Positives = 293/693 (42%), Gaps = 109/693 (15%)
Query: 418 PEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRP 477
P ++P + Q + Q A +E + +G A+ E++L P+ P
Sbjct: 988 PLDKEPARECAQRIAEQQKAQAEVEGLG--KGVARLSAEAEKVLAL-------PEPSPAA 1038
Query: 478 RTHHRGRYAWASEEDDASSLTADNLEKFGKLSAF---PEPPEDGTLLSEAKL---QSIMS 531
T + + SL+A LEK +S + E+ E +L Q++ +
Sbjct: 1039 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1098
Query: 532 FLDEME--KSGQDQLDSQQEGWVPEAGP------GPLELGSEVSTSVMRLKLEVEE-KKQ 582
L E+E K+ +L +Q E P G E+G + +EVE +++
Sbjct: 1099 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1158
Query: 583 AMLLLQR--ALAQQRDLTARRVKETEKALSRQLQRQREHYE---ATIQRHLAFIDQL--- 634
LL+R A+ Q D+ R +++ L RQL+ RE + A +Q +Q+
Sbjct: 1159 VAQLLERWQAVLAQTDVRQRELEQ----LGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1214
Query: 635 -IEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLK--ELMSATEKARREK 691
+ D + + E+ A L +E +R E+V + Q + I +K EL T KA+ E
Sbjct: 1215 PLADSQAVREQLRQEQA-LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1273
Query: 692 WISEKTKKIKEVTVRGLEPEIQKLI--ARHKQEVRRLKSLHEAELLQSDERASQRCLRQA 749
++ KK K + G E IQ+ + H E+ L S + + ++ LR+
Sbjct: 1274 -VASPAKKPKVQS--GSESVIQEYVDLRTHYSELTTLTSQYIKFISET--------LRRM 1322
Query: 750 EELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAA 809
EE +E L +Q+R R+R L + + AL++QRQ +AE + QA
Sbjct: 1323 EE--------EERLAEQQRAEERER----LAEVEAALEKQRQ-----LAEAHAQAKAQAE 1365
Query: 810 RQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELE-----RQ 864
R E +EL+Q+++E R E ++Q+R Q EL L+Q E E RQ
Sbjct: 1366 R---EAKELQQRMQEEV-----VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1417
Query: 865 AWEAGRTR---KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES 921
A A R+R +EE ++ + E E R G + E++ + R E A ++ E+A
Sbjct: 1418 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA--- 1474
Query: 922 RIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQA 981
+RLR + + E Q+E +L R EAE R+K+RAL+ +
Sbjct: 1475 --ERLRRQVQDESQRKRQAEVELASRVK------AEAEA--------AREKQRALQALEE 1518
Query: 982 VNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTAL 1041
+ Q L Q + A E R A+AEL + +A E +++ +L
Sbjct: 1519 LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA----SFAEKTAQLERSL 1574
Query: 1042 ARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 1074
+ AV+ LR + E ++ E E+ R
Sbjct: 1575 QEEHVAVAQLREEAERRAQQQAEAERAREEAER 1607
Score = 81.3 bits (199), Expect = 5e-15
Identities = 124/568 (21%), Positives = 251/568 (44%), Gaps = 71/568 (12%)
Query: 552 VPEAGPGPLELGSEVSTSVMRLK-------LEVEEKKQAMLLLQRALAQQRDLTAR--RV 602
+PE P L SE+ ++ +L+ + +E+ K L+++ + L A ++
Sbjct: 1031 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1090
Query: 603 KETE---------KALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELK 653
KE + +A L++ R EA A D+L ++V E+ + E
Sbjct: 1091 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV-GERLQQRHGERD 1149
Query: 654 QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARRE-KWISEKTKKIKEVTVRGLEPEI 712
E +R ERVAQ +++ + +++ T+ +RE + + + + +E +P
Sbjct: 1150 VEVERWRERVAQL-------LERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADP-- 1196
Query: 713 QKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERAR 772
+ Q+ RR + +A L +D +A + LRQ + L E++ER E + +E +R
Sbjct: 1197 ---LGAWLQDARRRQEQIQAMPL-ADSQAVREQLRQEQALLEEIERHGEKV--EECQRFA 1250
Query: 773 QRFQQHLEQEQWAL---QQQRQRLYSEVAEERERLGQQAARQR--------AELEELRQQ 821
+++ ++ + L + Q + + S + + + G ++ Q +EL L Q
Sbjct: 1251 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1310
Query: 822 LEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNR 881
+ S R + E E+ E+Q + L ++ LE +RQ EA K +A
Sbjct: 1311 YIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA----- 1364
Query: 882 EQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAEL------- 934
E+E +E ++ +++ V+ R EA A+ ++ +++ + +++LR EAE+
Sbjct: 1365 EREAKELQQRMQEE----VVRREEA--AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1418
Query: 935 SELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLA 994
E+S +++E ++ QL E + +G ++ E+A+A Q E L
Sbjct: 1419 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1478
Query: 995 QVIRQEFEDRLAASEEETRQAKAELATLQARQQL--ELEEVHRRVKTALARKEEAVSSLR 1052
+ ++ E + + A E + KAE + +Q+ LEE+ + + A R +A
Sbjct: 1479 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1538
Query: 1053 TQHEAAVKRADHLEELLEQHRRPTPSTK 1080
Q + A++ A E Q +R + + K
Sbjct: 1539 RQVQVALETAQRSAEAELQSKRASFAEK 1566
Score = 57.4 bits (137), Expect = 7e-08
Identities = 95/384 (24%), Positives = 157/384 (40%), Gaps = 62/384 (16%)
Query: 728 SLHEAELLQS------DERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQ 781
S H +LLQS +E QRC+ + +++R QLE + R R + L++
Sbjct: 940 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE--------TRTVHRLRLPLDK 991
Query: 782 EQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGR 841
E QR + E E LG+ AR AE E++ E S +A T E G+
Sbjct: 992 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1051
Query: 842 EEQERR----HQMELNTLKQQLELERQAWEAGRTRKEE--------AWLLNRE------- 882
EQ R + +L T+ + + A E R +E+ A L E
Sbjct: 1052 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1111
Query: 883 -------------QELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDK 929
LR+E+R ++ V RL+ E E+ E R+ +L ++
Sbjct: 1112 KLRAQAEAQQPTFDALRDELRGAQE-----VGERLQQRHGERDVEVERWRE-RVAQLLER 1165
Query: 930 YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKER----ALEDAQAVNEQ 985
++A L++ + +R+L++ +L+ A+ LQ R++E+ L D+QAV EQ
Sbjct: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ-QLELEEVHRRVKTALARK 1044
L E Q + +E E EE R AK + ++ + QL + + A+K
Sbjct: 1226 LRQE-----QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1280
Query: 1045 EEAVSSLRTQHEAAVKRADHLEEL 1068
+ S + + V H EL
Sbjct: 1281 PKVQSGSESVIQEYVDLRTHYSEL 1304
Score = 39.7 bits (91), Expect = 0.016
Identities = 96/429 (22%), Positives = 180/429 (41%), Gaps = 71/429 (16%)
Query: 627 HLAFIDQLIEDKKVLSE----KC-EAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELM 681
H+A +++ +K++ SE +C + +V +L+ E C E++ QA A + +++ L+
Sbjct: 352 HVAILER---EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR----LL 404
Query: 682 SATEKARREKWISEKTKKIKEVTVRGLEPEIQKLI-ARH---KQEVRRLKSLHEAELLQS 737
+A + +R + K + +R L ++Q L RH +Q RR+ LHE +
Sbjct: 405 AAGKVPQRAGEVERDLDKADSM-IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR 463
Query: 738 DERASQRCLRQAEELREQLEREKEALGQQ-ERERARQRFQQHLEQEQWALQQQRQRLYSE 796
E + A + + +++ ++ E E + R+ Q L W + Q + +E
Sbjct: 464 TEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA--WVEENQHRVDGAE 521
Query: 797 VAEERERLGQQAARQRA---ELEELRQQLEESSS---ALTRALRAEFEKGREEQERRHQM 850
+ + Q R +EE R ++E + S L+ A R + + ++
Sbjct: 522 WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 581
Query: 851 ELNTLKQQLE-LERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMA 909
LN+ K +L LE KE WL +E+E E D+ + + E+ A
Sbjct: 582 LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE--EVGFDWSDRNTNMTAKK-ESYSA 638
Query: 910 LAKEESEKAAESRIKRLRDKYEAELSE-------LEQSERKLQERCS------------- 949
L +E K E +IK L++ + L E +E + LQ + S
Sbjct: 639 LMRELELK--EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 696
Query: 950 -------ELKGQLGEAEGENLRLQGLVRQK------------ERALEDAQAVNEQLSSER 990
+ + EAEG+ +LQ +R+K E L+DAQ EQL+ +
Sbjct: 697 KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 756
Query: 991 SNLAQVIRQ 999
+L+ + ++
Sbjct: 757 GHLSGLAKR 765
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 150 bits (380), Expect = 5e-36
Identities = 209/886 (23%), Positives = 356/886 (40%), Gaps = 131/886 (14%)
Query: 280 RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA 339
R ++ A + L +A + + Q E L Q+E RR+ A+Q +R+
Sbjct: 1345 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1404
Query: 340 IQELQQKRA-------LRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL 392
+ELQQ R +A++A AER E RV ++ A E QAL
Sbjct: 1405 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1464
Query: 393 KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK 452
+A R + Q+ E + V + E+ SR A+
Sbjct: 1465 RA--------------RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1510
Query: 453 SRGPLE-----ELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGK 507
+ E + L L+L +E + R R R + E S A E K
Sbjct: 1511 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA---ELQSK 1567
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
++F E + + ++ +E E+ Q Q ++++ E LE +
Sbjct: 1568 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER---AREEAERELERWQLKA 1624
Query: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA----------LSRQLQRQR 617
+RL+L+ EE Q L Q +Q++ R + KA ++L++QR
Sbjct: 1625 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1684
Query: 618 EHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKL 677
+ E T Q+ LA +LI + A + +Q+ Q E +A+ Q + +K
Sbjct: 1685 QLAEGTAQQRLAAEQELI--------RLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1736
Query: 678 KELMSATEKARREKWI--------SEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSL 729
+EL + K R E + E+++ E + + LE E + +E RL++L
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARLRAL 1795
Query: 730 HEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQ 789
E E + + A + RQ E L + A+G+ R + +E+ A ++
Sbjct: 1796 AE-EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL---KEKEAENER 1851
Query: 790 RQRLYSEVAEERERLGQQAARQRAELEELRQQLEESS-SALTR----------------- 831
+RL + A +R RL +QAA+ +A++EE QL ++S S L R
Sbjct: 1852 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1911
Query: 832 ---ALRAEFEK---GREEQERRHQMELNTLKQQLE-----LERQAWEAGRTRKEEAWLLN 880
AL+A FEK G+ E E +EL ++ E E+ EA R R+ A
Sbjct: 1912 EILALKASFEKAAAGKAELE----LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1967
Query: 881 REQELREEIRKGRDKEIELV---------IHRLEADMALAKEESEKAA-----------E 920
R +E E ++K E E + RL+A + A+ E+A E
Sbjct: 1968 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2027
Query: 921 SRIKRLRDKYEAELSELEQSERKLQERCSELKGQL----GEAEG--------ENLRLQGL 968
+ KRL+ + +A ++Q E++LQ+ + + L GEAE E R+Q
Sbjct: 2028 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2087
Query: 969 --VRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ 1026
Q R +E+A+ + + + AQ + R A +E R+A+AE A L+ +Q
Sbjct: 2088 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ 2147
Query: 1027 QLELE-EVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1071
+ E E H++ R++ V T ++ DH + LL++
Sbjct: 2148 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2193
Score = 135 bits (339), Expect = 3e-31
Identities = 238/962 (24%), Positives = 398/962 (41%), Gaps = 146/962 (15%)
Query: 245 GGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQ 304
GG+ G + EEAE Q + ++R + + QR+ L ++A+ E
Sbjct: 1455 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1514
Query: 305 RQRSGE-GTLLDLHQQKEAARRKARE---EKARQ-------ARRAAIQELQQKRALRAQK 353
R++ L +L Q E A R+ R+ E+ARQ A+R+A ELQ KRA A+K
Sbjct: 1515 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1574
Query: 354 ASTAERGPPE---------NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAA 404
+ ER E E R + + LKAN A
Sbjct: 1575 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1634
Query: 405 GPGDRCLPTSDSSPEPQQPPEDR---------TQDVLAQDAAGDNLEMMAP-SRGSAKSR 454
+ + + E Q+ +R Q V ++ A LE + G+A+ R
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1694
Query: 455 GPLEELLHTL-----------QLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLE 503
E+ L L QLLE+E R A ++ + L E
Sbjct: 1695 LAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAELAKVRAE 1749
Query: 504 KFGKLSAFPEPPEDGTLLSEAKLQSIMS----FLDEMEKSGQ-----DQLDSQQEGWVPE 554
L++ E+ SE Q + + F + E++ + ++ Q++ +
Sbjct: 1750 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1809
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
A E ++ + + K +A + L+ A+ L RR+ E E R+L+
Sbjct: 1810 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLE 1867
Query: 615 RQREHYEATIQRHLAFI----DQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQ 667
Q ++A I+ LA + D +E +K L E ++++E + E+ A +
Sbjct: 1868 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1927
Query: 668 AQHELEIKKLK----ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
A+ ELE+ +++ + + + E+A E + +E R E +QK +A ++
Sbjct: 1928 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1987
Query: 724 RRLK-SLHEAELLQSD--------ERASQRCLRQ------AEELREQLEREKEALGQQER 768
R+ K +L E E L++ ERA Q RQ A + R Q E + A Q++
Sbjct: 1988 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2047
Query: 769 ERARQRFQQHLEQEQWALQQQR-----QRLYSEVAEE----RERLGQQAARQRAELEELR 819
E Q QQ L+QEQ L Q R R +E AEE ER Q+ RQ E E L+
Sbjct: 2048 E---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2104
Query: 820 QQLEESSSALTRALRAEFEKGREEQE----RRHQMELNTLKQQ----LELERQAWEAGRT 871
Q EE + A +A +A EK R+E E RR Q E L+Q+ E+E+ A +T
Sbjct: 2105 QSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2163
Query: 872 RKEEAWLLNREQELREEIRKGRDKE--IELVIHRLEADMALAKEESEKAAE--------- 920
+++A + LR ++ + ++ ++ + RL+A+ A + + E
Sbjct: 2164 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2223
Query: 921 SRIKRLRDKYEAE-----LSELEQSERKLQERCSELK------GQLGEAEGENLRLQGLV 969
+ +L+ + EAE L + + ++R LQE ++K +L A E RL+ L
Sbjct: 2224 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2283
Query: 970 RQ---KERAL------EDAQAVNE--QLSSERSNLAQ--VIRQEFEDRLAASEEETRQAK 1016
+ ++RAL E QAV E +L +E L Q + QE RL +E+ Q
Sbjct: 2284 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2343
Query: 1017 AE-----LATLQA--RQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELL 1069
AE TL+A ++QLE+ R+K +A A + + K+A+ + E L
Sbjct: 2344 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2403
Query: 1070 EQ 1071
+
Sbjct: 2404 HR 2405
Score = 129 bits (325), Expect = 1e-29
Identities = 220/871 (25%), Positives = 371/871 (42%), Gaps = 121/871 (13%)
Query: 252 RRKEVTEEEAERFIHQVNQATV--TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
+ K+ E EA RF +A + + Q Q AAR + E+ G
Sbjct: 1770 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1829
Query: 310 EGTLLDLH-----QQKEAARRKAR---EEKARQARRAAIQELQQK-----RALRAQKAST 356
E T L ++KEA + R E++A Q RR Q Q K R + +KAS
Sbjct: 1830 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1889
Query: 357 AERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS 416
+E + E + RQ +E+ ALKA+ AAG + L
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEIL---------ALKASFEKA---AAGKAELELELGRI 1937
Query: 417 SPEPQQPPEDRTQDVLA-----QDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q L Q AA + KS EE + +E
Sbjct: 1938 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1997
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ L + + R +E++ A L +L A + E +LQ +
Sbjct: 1998 ERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL- 2055
Query: 532 FLDEMEKSGQDQLDSQQEGW---VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ 588
+ E+S DQL + E EA ++ E + S +++ E E KQ+
Sbjct: 2056 ---QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2111
Query: 589 RALAQQRDLTARRVKETEKALSRQLQ------RQREHYEATIQRHLAFIDQLIEDKKVLS 642
+A AQ + + KE E+ +R+ Q RQ++ +A +++H F +Q + K +
Sbjct: 2112 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2171
Query: 643 EKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKE 702
++ + +L++ D + + + E+++LK ATE AR+ + E+
Sbjct: 2172 QELTTLRLQLEETDHQ--------KNLLDEELQRLKA--EATEAARQRSQVEEEL----- 2216
Query: 703 VTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEA 762
+VR E+ KL AR + E R L + D+ +QR L++ E +Q+ E
Sbjct: 2217 FSVRVQMEELSKLKARIEAENRAL--------ILRDKDNTQRFLQEEAEKMKQVAEEAAR 2268
Query: 763 LGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQL 822
L +E AR R L +E A Q++ L ++ +E+ + Q+A R +AE E L+QQ
Sbjct: 2269 LSVAAQEAARLR---QLAEEDLA---QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2322
Query: 823 EESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQ-----AWEAGRTRKEEAW 877
E + R ++ +E+ ++ E ++ LE ERQ + EA R + A
Sbjct: 2323 ELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2377
Query: 878 LLNREQELREEIRKGRDK--EIELVIHRLEADMALAKEESEKAAES-RIKRLRDKYEAE- 933
+ + E+ ++ R + EI +HR E LA +E ++ I+R + ++AE
Sbjct: 2378 MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAER 2433
Query: 934 ----LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSE 989
++ELE+ + KLQ+ L QL E + + Q+E+ L++ QA+ + SE
Sbjct: 2434 LREAIAELEREKEKLQQEAKLL--QLKSEEMQTV-------QQEQLLQETQALQQSFLSE 2484
Query: 990 RSNLAQVIRQEFEDRLAASEEETRQ---AKAE-LATLQARQQLELEEVHRRVKTALARKE 1045
+ +L Q R+ F ++ A E+ Q AKA+ L Q RQQ ++E+ +R+ +A E
Sbjct: 2485 KDSLLQ--RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASME 2539
Query: 1046 EAVSSLRTQHEA--AVKRADHLEELLEQHRR 1074
EA R QHEA V+R + LEQ RR
Sbjct: 2540 EA---RRRQHEAEEGVRRKQEELQQLEQQRR 2567
Score = 108 bits (269), Expect = 4e-23
Identities = 194/856 (22%), Positives = 346/856 (40%), Gaps = 105/856 (12%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG 287
++ K++++ +AR + R K EE A R + Q + + + Q+R
Sbjct: 1975 RVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERAEQESARQLQLAQEAAQKRL 2033
Query: 288 AGAARLEHLLQAKREEQRQRS--GEGTLLD-LHQQKEAARRKARE-EKAR-QARRAAIQE 342
+ ++E++ Q++ E ++LD L + EAARR A E E+AR QA R A Q
Sbjct: 2034 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2093
Query: 343 LQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLP 402
+Q K S E+ + +R+ A++ + AL+
Sbjct: 2094 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA----- 2148
Query: 403 AAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLH 462
+D+ E + ++T AQ + R LEE H
Sbjct: 2149 -----------ADAEMEKHKKFAEQTLRQKAQ-----------VEQELTTLRLQLEETDH 2186
Query: 463 TLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS 522
LL++E L T + + EE + + +E+ KL A E +L
Sbjct: 2187 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV---QMEELSKLKARIEAENRALILR 2243
Query: 523 EAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQ 582
+ D ++ Q++ + ++ V+ RL + +E +
Sbjct: 2244 DK---------DNTQRFLQEEAEKMKQ----------------VAEEAARLSVAAQEAAR 2278
Query: 583 AMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFID--QLIEDKKV 640
L + LAQQR L + +KE +A+ + + E Q+ LA +L EDK+
Sbjct: 2279 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2338
Query: 641 LSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKI 700
++++ +AE Q QR E Q Q + E ++LK + E +R + E ++
Sbjct: 2339 MAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLK--LRVAEMSRAQARAEEDAQRF 2392
Query: 701 KEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELRE---QLE 757
++ E +KL H+ E L + + L+Q+ E Q+ AE LRE +LE
Sbjct: 2393 RKQA----EEIGEKL---HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2442
Query: 758 REKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEE 817
REKE L QQE + + + ++ +Q L Q+ Q L E++ L Q+ E +
Sbjct: 2443 REKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2501
Query: 818 LRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAW 877
L +QL + A + LR E ++ +++ E+ Q + ++++ + +A E R ++EE
Sbjct: 2502 L-EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2560
Query: 878 LLNREQELREEIRKGRDKEIELVIHRLEAD--MALAKEE----SEKAAESRIKRLRDKYE 931
L +++ +EE+ ++ + + LE ALA E S+ AA + RD +
Sbjct: 2561 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2620
Query: 932 AELSELEQS------ERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQ 985
+E E RK+ + + G L E + L QG E L + V
Sbjct: 2621 GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL-AQGHTTVDE--LARREDVRHY 2677
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAE-----LATLQARQQLELEEVHRRVKTA 1040
L RS++A ++ + ++L+ RQ + L QA L+ V R T
Sbjct: 2678 LQG-RSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTV 2736
Query: 1041 LARKEEAVSSLRTQHE 1056
+E V H+
Sbjct: 2737 NEAVKEGVVGPELHHK 2752
Score = 95.1 bits (235), Expect = 3e-19
Identities = 174/693 (25%), Positives = 293/693 (42%), Gaps = 109/693 (15%)
Query: 418 PEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRP 477
P ++P + Q + Q A +E + +G A+ E++L P+ P
Sbjct: 996 PLDKEPARECAQRIAEQQKAQAEVEGLG--KGVARLSAEAEKVLAL-------PEPSPAA 1046
Query: 478 RTHHRGRYAWASEEDDASSLTADNLEKFGKLSAF---PEPPEDGTLLSEAKL---QSIMS 531
T + + SL+A LEK +S + E+ E +L Q++ +
Sbjct: 1047 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1106
Query: 532 FLDEME--KSGQDQLDSQQEGWVPEAGP------GPLELGSEVSTSVMRLKLEVEE-KKQ 582
L E+E K+ +L +Q E P G E+G + +EVE +++
Sbjct: 1107 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1166
Query: 583 AMLLLQR--ALAQQRDLTARRVKETEKALSRQLQRQREHYE---ATIQRHLAFIDQL--- 634
LL+R A+ Q D+ R +++ L RQL+ RE + A +Q +Q+
Sbjct: 1167 VAQLLERWQAVLAQTDVRQRELEQ----LGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1222
Query: 635 -IEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLK--ELMSATEKARREK 691
+ D + + E+ A L +E +R E+V + Q + I +K EL T KA+ E
Sbjct: 1223 PLADSQAVREQLRQEQA-LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1281
Query: 692 WISEKTKKIKEVTVRGLEPEIQKLI--ARHKQEVRRLKSLHEAELLQSDERASQRCLRQA 749
++ KK K + G E IQ+ + H E+ L S + + ++ LR+
Sbjct: 1282 -VASPAKKPKVQS--GSESVIQEYVDLRTHYSELTTLTSQYIKFISET--------LRRM 1330
Query: 750 EELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAA 809
EE +E L +Q+R R+R L + + AL++QRQ +AE + QA
Sbjct: 1331 EE--------EERLAEQQRAEERER----LAEVEAALEKQRQ-----LAEAHAQAKAQAE 1373
Query: 810 RQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELE-----RQ 864
R E +EL+Q+++E R E ++Q+R Q EL L+Q E E RQ
Sbjct: 1374 R---EAKELQQRMQEEV-----VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1425
Query: 865 AWEAGRTR---KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES 921
A A R+R +EE ++ + E E R G + E++ + R E A ++ E+A
Sbjct: 1426 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA--- 1482
Query: 922 RIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQA 981
+RLR + + E Q+E +L R EAE R+K+RAL+ +
Sbjct: 1483 --ERLRRQVQDESQRKRQAEVELASRVK------AEAEA--------AREKQRALQALEE 1526
Query: 982 VNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTAL 1041
+ Q L Q + A E R A+AEL + +A E +++ +L
Sbjct: 1527 LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA----SFAEKTAQLERSL 1582
Query: 1042 ARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 1074
+ AV+ LR + E ++ E E+ R
Sbjct: 1583 QEEHVAVAQLREEAERRAQQQAEAERAREEAER 1615
Score = 81.3 bits (199), Expect = 5e-15
Identities = 124/568 (21%), Positives = 251/568 (44%), Gaps = 71/568 (12%)
Query: 552 VPEAGPGPLELGSEVSTSVMRLK-------LEVEEKKQAMLLLQRALAQQRDLTAR--RV 602
+PE P L SE+ ++ +L+ + +E+ K L+++ + L A ++
Sbjct: 1039 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1098
Query: 603 KETE---------KALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELK 653
KE + +A L++ R EA A D+L ++V E+ + E
Sbjct: 1099 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV-GERLQQRHGERD 1157
Query: 654 QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARRE-KWISEKTKKIKEVTVRGLEPEI 712
E +R ERVAQ +++ + +++ T+ +RE + + + + +E +P
Sbjct: 1158 VEVERWRERVAQL-------LERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADP-- 1204
Query: 713 QKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERAR 772
+ Q+ RR + +A L +D +A + LRQ + L E++ER E + +E +R
Sbjct: 1205 ---LGAWLQDARRRQEQIQAMPL-ADSQAVREQLRQEQALLEEIERHGEKV--EECQRFA 1258
Query: 773 QRFQQHLEQEQWAL---QQQRQRLYSEVAEERERLGQQAARQR--------AELEELRQQ 821
+++ ++ + L + Q + + S + + + G ++ Q +EL L Q
Sbjct: 1259 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1318
Query: 822 LEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNR 881
+ S R + E E+ E+Q + L ++ LE +RQ EA K +A
Sbjct: 1319 YIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA----- 1372
Query: 882 EQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAEL------- 934
E+E +E ++ +++ V+ R EA A+ ++ +++ + +++LR EAE+
Sbjct: 1373 EREAKELQQRMQEE----VVRREEA--AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1426
Query: 935 SELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLA 994
E+S +++E ++ QL E + +G ++ E+A+A Q E L
Sbjct: 1427 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1486
Query: 995 QVIRQEFEDRLAASEEETRQAKAELATLQARQQL--ELEEVHRRVKTALARKEEAVSSLR 1052
+ ++ E + + A E + KAE + +Q+ LEE+ + + A R +A
Sbjct: 1487 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1546
Query: 1053 TQHEAAVKRADHLEELLEQHRRPTPSTK 1080
Q + A++ A E Q +R + + K
Sbjct: 1547 RQVQVALETAQRSAEAELQSKRASFAEK 1574
Score = 57.4 bits (137), Expect = 7e-08
Identities = 95/384 (24%), Positives = 157/384 (40%), Gaps = 62/384 (16%)
Query: 728 SLHEAELLQS------DERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQ 781
S H +LLQS +E QRC+ + +++R QLE + R R + L++
Sbjct: 948 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE--------TRTVHRLRLPLDK 999
Query: 782 EQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGR 841
E QR + E E LG+ AR AE E++ E S +A T E G+
Sbjct: 1000 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1059
Query: 842 EEQERR----HQMELNTLKQQLELERQAWEAGRTRKEE--------AWLLNRE------- 882
EQ R + +L T+ + + A E R +E+ A L E
Sbjct: 1060 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1119
Query: 883 -------------QELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDK 929
LR+E+R ++ V RL+ E E+ E R+ +L ++
Sbjct: 1120 KLRAQAEAQQPTFDALRDELRGAQE-----VGERLQQRHGERDVEVERWRE-RVAQLLER 1173
Query: 930 YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKER----ALEDAQAVNEQ 985
++A L++ + +R+L++ +L+ A+ LQ R++E+ L D+QAV EQ
Sbjct: 1174 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1233
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ-QLELEEVHRRVKTALARK 1044
L E Q + +E E EE R AK + ++ + QL + + A+K
Sbjct: 1234 LRQE-----QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1288
Query: 1045 EEAVSSLRTQHEAAVKRADHLEEL 1068
+ S + + V H EL
Sbjct: 1289 PKVQSGSESVIQEYVDLRTHYSEL 1312
Score = 39.7 bits (91), Expect = 0.016
Identities = 96/429 (22%), Positives = 180/429 (41%), Gaps = 71/429 (16%)
Query: 627 HLAFIDQLIEDKKVLSE----KC-EAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELM 681
H+A +++ +K++ SE +C + +V +L+ E C E++ QA A + +++ L+
Sbjct: 360 HVAILER---EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR----LL 412
Query: 682 SATEKARREKWISEKTKKIKEVTVRGLEPEIQKLI-ARH---KQEVRRLKSLHEAELLQS 737
+A + +R + K + +R L ++Q L RH +Q RR+ LHE +
Sbjct: 413 AAGKVPQRAGEVERDLDKADSM-IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR 471
Query: 738 DERASQRCLRQAEELREQLEREKEALGQQ-ERERARQRFQQHLEQEQWALQQQRQRLYSE 796
E + A + + +++ ++ E E + R+ Q L W + Q + +E
Sbjct: 472 TEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA--WVEENQHRVDGAE 529
Query: 797 VAEERERLGQQAARQRA---ELEELRQQLEESSS---ALTRALRAEFEKGREEQERRHQM 850
+ + Q R +EE R ++E + S L+ A R + + ++
Sbjct: 530 WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 589
Query: 851 ELNTLKQQLE-LERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMA 909
LN+ K +L LE KE WL +E+E E D+ + + E+ A
Sbjct: 590 LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE--EVGFDWSDRNTNMTAKK-ESYSA 646
Query: 910 LAKEESEKAAESRIKRLRDKYEAELSE-------LEQSERKLQERCS------------- 949
L +E K E +IK L++ + L E +E + LQ + S
Sbjct: 647 LMRELELK--EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 704
Query: 950 -------ELKGQLGEAEGENLRLQGLVRQK------------ERALEDAQAVNEQLSSER 990
+ + EAEG+ +LQ +R+K E L+DAQ EQL+ +
Sbjct: 705 KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 764
Query: 991 SNLAQVIRQ 999
+L+ + ++
Sbjct: 765 GHLSGLAKR 773
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 150 bits (380), Expect = 5e-36
Identities = 209/886 (23%), Positives = 356/886 (40%), Gaps = 131/886 (14%)
Query: 280 RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA 339
R ++ A + L +A + + Q E L Q+E RR+ A+Q +R+
Sbjct: 1386 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1445
Query: 340 IQELQQKRA-------LRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL 392
+ELQQ R +A++A AER E RV ++ A E QAL
Sbjct: 1446 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1505
Query: 393 KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK 452
+A R + Q+ E + V + E+ SR A+
Sbjct: 1506 RA--------------RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1551
Query: 453 SRGPLE-----ELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGK 507
+ E + L L+L +E + R R R + E S A E K
Sbjct: 1552 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA---ELQSK 1608
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
++F E + + ++ +E E+ Q Q ++++ E LE +
Sbjct: 1609 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER---AREEAERELERWQLKA 1665
Query: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA----------LSRQLQRQR 617
+RL+L+ EE Q L Q +Q++ R + KA ++L++QR
Sbjct: 1666 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1725
Query: 618 EHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKL 677
+ E T Q+ LA +LI + A + +Q+ Q E +A+ Q + +K
Sbjct: 1726 QLAEGTAQQRLAAEQELI--------RLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1777
Query: 678 KELMSATEKARREKWI--------SEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSL 729
+EL + K R E + E+++ E + + LE E + +E RL++L
Sbjct: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARLRAL 1836
Query: 730 HEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQ 789
E E + + A + RQ E L + A+G+ R + +E+ A ++
Sbjct: 1837 AE-EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL---KEKEAENER 1892
Query: 790 RQRLYSEVAEERERLGQQAARQRAELEELRQQLEESS-SALTR----------------- 831
+RL + A +R RL +QAA+ +A++EE QL ++S S L R
Sbjct: 1893 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1952
Query: 832 ---ALRAEFEK---GREEQERRHQMELNTLKQQLE-----LERQAWEAGRTRKEEAWLLN 880
AL+A FEK G+ E E +EL ++ E E+ EA R R+ A
Sbjct: 1953 EILALKASFEKAAAGKAELE----LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 2008
Query: 881 REQELREEIRKGRDKEIELV---------IHRLEADMALAKEESEKAA-----------E 920
R +E E ++K E E + RL+A + A+ E+A E
Sbjct: 2009 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2068
Query: 921 SRIKRLRDKYEAELSELEQSERKLQERCSELKGQL----GEAEG--------ENLRLQGL 968
+ KRL+ + +A ++Q E++LQ+ + + L GEAE E R+Q
Sbjct: 2069 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2128
Query: 969 --VRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ 1026
Q R +E+A+ + + + AQ + R A +E R+A+AE A L+ +Q
Sbjct: 2129 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ 2188
Query: 1027 QLELE-EVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1071
+ E E H++ R++ V T ++ DH + LL++
Sbjct: 2189 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2234
Score = 135 bits (339), Expect = 3e-31
Identities = 238/962 (24%), Positives = 398/962 (41%), Gaps = 146/962 (15%)
Query: 245 GGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQ 304
GG+ G + EEAE Q + ++R + + QR+ L ++A+ E
Sbjct: 1496 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1555
Query: 305 RQRSGE-GTLLDLHQQKEAARRKARE---EKARQ-------ARRAAIQELQQKRALRAQK 353
R++ L +L Q E A R+ R+ E+ARQ A+R+A ELQ KRA A+K
Sbjct: 1556 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1615
Query: 354 ASTAERGPPE---------NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAA 404
+ ER E E R + + LKAN A
Sbjct: 1616 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1675
Query: 405 GPGDRCLPTSDSSPEPQQPPEDR---------TQDVLAQDAAGDNLEMMAP-SRGSAKSR 454
+ + + E Q+ +R Q V ++ A LE + G+A+ R
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1735
Query: 455 GPLEELLHTL-----------QLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLE 503
E+ L L QLLE+E R A ++ + L E
Sbjct: 1736 LAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAELAKVRAE 1790
Query: 504 KFGKLSAFPEPPEDGTLLSEAKLQSIMS----FLDEMEKSGQ-----DQLDSQQEGWVPE 554
L++ E+ SE Q + + F + E++ + ++ Q++ +
Sbjct: 1791 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1850
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
A E ++ + + K +A + L+ A+ L RR+ E E R+L+
Sbjct: 1851 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLE 1908
Query: 615 RQREHYEATIQRHLAFI----DQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQ 667
Q ++A I+ LA + D +E +K L E ++++E + E+ A +
Sbjct: 1909 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1968
Query: 668 AQHELEIKKLK----ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
A+ ELE+ +++ + + + E+A E + +E R E +QK +A ++
Sbjct: 1969 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2028
Query: 724 RRLK-SLHEAELLQSD--------ERASQRCLRQ------AEELREQLEREKEALGQQER 768
R+ K +L E E L++ ERA Q RQ A + R Q E + A Q++
Sbjct: 2029 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2088
Query: 769 ERARQRFQQHLEQEQWALQQQR-----QRLYSEVAEE----RERLGQQAARQRAELEELR 819
E Q QQ L+QEQ L Q R R +E AEE ER Q+ RQ E E L+
Sbjct: 2089 E---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2145
Query: 820 QQLEESSSALTRALRAEFEKGREEQE----RRHQMELNTLKQQ----LELERQAWEAGRT 871
Q EE + A +A +A EK R+E E RR Q E L+Q+ E+E+ A +T
Sbjct: 2146 QSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2204
Query: 872 RKEEAWLLNREQELREEIRKGRDKE--IELVIHRLEADMALAKEESEKAAE--------- 920
+++A + LR ++ + ++ ++ + RL+A+ A + + E
Sbjct: 2205 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2264
Query: 921 SRIKRLRDKYEAE-----LSELEQSERKLQERCSELK------GQLGEAEGENLRLQGLV 969
+ +L+ + EAE L + + ++R LQE ++K +L A E RL+ L
Sbjct: 2265 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2324
Query: 970 RQ---KERAL------EDAQAVNE--QLSSERSNLAQ--VIRQEFEDRLAASEEETRQAK 1016
+ ++RAL E QAV E +L +E L Q + QE RL +E+ Q
Sbjct: 2325 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2384
Query: 1017 AE-----LATLQA--RQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELL 1069
AE TL+A ++QLE+ R+K +A A + + K+A+ + E L
Sbjct: 2385 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2444
Query: 1070 EQ 1071
+
Sbjct: 2445 HR 2446
Score = 129 bits (325), Expect = 1e-29
Identities = 220/871 (25%), Positives = 371/871 (42%), Gaps = 121/871 (13%)
Query: 252 RRKEVTEEEAERFIHQVNQATV--TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
+ K+ E EA RF +A + + Q Q AAR + E+ G
Sbjct: 1811 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1870
Query: 310 EGTLLDLH-----QQKEAARRKAR---EEKARQARRAAIQELQQK-----RALRAQKAST 356
E T L ++KEA + R E++A Q RR Q Q K R + +KAS
Sbjct: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930
Query: 357 AERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS 416
+E + E + RQ +E+ ALKA+ AAG + L
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEIL---------ALKASFEKA---AAGKAELELELGRI 1978
Query: 417 SPEPQQPPEDRTQDVLA-----QDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q L Q AA + KS EE + +E
Sbjct: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2038
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ L + + R +E++ A L +L A + E +LQ +
Sbjct: 2039 ERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL- 2096
Query: 532 FLDEMEKSGQDQLDSQQEGW---VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ 588
+ E+S DQL + E EA ++ E + S +++ E E KQ+
Sbjct: 2097 ---QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2152
Query: 589 RALAQQRDLTARRVKETEKALSRQLQ------RQREHYEATIQRHLAFIDQLIEDKKVLS 642
+A AQ + + KE E+ +R+ Q RQ++ +A +++H F +Q + K +
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2212
Query: 643 EKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKE 702
++ + +L++ D + + + E+++LK ATE AR+ + E+
Sbjct: 2213 QELTTLRLQLEETDHQ--------KNLLDEELQRLKA--EATEAARQRSQVEEEL----- 2257
Query: 703 VTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEA 762
+VR E+ KL AR + E R L + D+ +QR L++ E +Q+ E
Sbjct: 2258 FSVRVQMEELSKLKARIEAENRAL--------ILRDKDNTQRFLQEEAEKMKQVAEEAAR 2309
Query: 763 LGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQL 822
L +E AR R L +E A Q++ L ++ +E+ + Q+A R +AE E L+QQ
Sbjct: 2310 LSVAAQEAARLR---QLAEEDLA---QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2363
Query: 823 EESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQ-----AWEAGRTRKEEAW 877
E + R ++ +E+ ++ E ++ LE ERQ + EA R + A
Sbjct: 2364 ELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2418
Query: 878 LLNREQELREEIRKGRDK--EIELVIHRLEADMALAKEESEKAAES-RIKRLRDKYEAE- 933
+ + E+ ++ R + EI +HR E LA +E ++ I+R + ++AE
Sbjct: 2419 MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAER 2474
Query: 934 ----LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSE 989
++ELE+ + KLQ+ L QL E + + Q+E+ L++ QA+ + SE
Sbjct: 2475 LREAIAELEREKEKLQQEAKLL--QLKSEEMQTV-------QQEQLLQETQALQQSFLSE 2525
Query: 990 RSNLAQVIRQEFEDRLAASEEETRQ---AKAE-LATLQARQQLELEEVHRRVKTALARKE 1045
+ +L Q R+ F ++ A E+ Q AKA+ L Q RQQ ++E+ +R+ +A E
Sbjct: 2526 KDSLLQ--RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASME 2580
Query: 1046 EAVSSLRTQHEA--AVKRADHLEELLEQHRR 1074
EA R QHEA V+R + LEQ RR
Sbjct: 2581 EA---RRRQHEAEEGVRRKQEELQQLEQQRR 2608
Score = 108 bits (269), Expect = 4e-23
Identities = 194/856 (22%), Positives = 346/856 (40%), Gaps = 105/856 (12%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG 287
++ K++++ +AR + R K EE A R + Q + + + Q+R
Sbjct: 2016 RVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERAEQESARQLQLAQEAAQKRL 2074
Query: 288 AGAARLEHLLQAKREEQRQRS--GEGTLLD-LHQQKEAARRKARE-EKAR-QARRAAIQE 342
+ ++E++ Q++ E ++LD L + EAARR A E E+AR QA R A Q
Sbjct: 2075 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2134
Query: 343 LQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLP 402
+Q K S E+ + +R+ A++ + AL+
Sbjct: 2135 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA----- 2189
Query: 403 AAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLH 462
+D+ E + ++T AQ + R LEE H
Sbjct: 2190 -----------ADAEMEKHKKFAEQTLRQKAQ-----------VEQELTTLRLQLEETDH 2227
Query: 463 TLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS 522
LL++E L T + + EE + + +E+ KL A E +L
Sbjct: 2228 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV---QMEELSKLKARIEAENRALILR 2284
Query: 523 EAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQ 582
+ D ++ Q++ + ++ V+ RL + +E +
Sbjct: 2285 DK---------DNTQRFLQEEAEKMKQ----------------VAEEAARLSVAAQEAAR 2319
Query: 583 AMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFID--QLIEDKKV 640
L + LAQQR L + +KE +A+ + + E Q+ LA +L EDK+
Sbjct: 2320 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2379
Query: 641 LSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKI 700
++++ +AE Q QR E Q Q + E ++LK + E +R + E ++
Sbjct: 2380 MAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLK--LRVAEMSRAQARAEEDAQRF 2433
Query: 701 KEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELRE---QLE 757
++ E +KL H+ E L + + L+Q+ E Q+ AE LRE +LE
Sbjct: 2434 RKQA----EEIGEKL---HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2483
Query: 758 REKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEE 817
REKE L QQE + + + ++ +Q L Q+ Q L E++ L Q+ E +
Sbjct: 2484 REKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2542
Query: 818 LRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAW 877
L +QL + A + LR E ++ +++ E+ Q + ++++ + +A E R ++EE
Sbjct: 2543 L-EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2601
Query: 878 LLNREQELREEIRKGRDKEIELVIHRLEAD--MALAKEE----SEKAAESRIKRLRDKYE 931
L +++ +EE+ ++ + + LE ALA E S+ AA + RD +
Sbjct: 2602 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2661
Query: 932 AELSELEQS------ERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQ 985
+E E RK+ + + G L E + L QG E L + V
Sbjct: 2662 GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL-AQGHTTVDE--LARREDVRHY 2718
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAE-----LATLQARQQLELEEVHRRVKTA 1040
L RS++A ++ + ++L+ RQ + L QA L+ V R T
Sbjct: 2719 LQG-RSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTV 2777
Query: 1041 LARKEEAVSSLRTQHE 1056
+E V H+
Sbjct: 2778 NEAVKEGVVGPELHHK 2793
Score = 95.1 bits (235), Expect = 3e-19
Identities = 174/693 (25%), Positives = 293/693 (42%), Gaps = 109/693 (15%)
Query: 418 PEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRP 477
P ++P + Q + Q A +E + +G A+ E++L P+ P
Sbjct: 1037 PLDKEPARECAQRIAEQQKAQAEVEGLG--KGVARLSAEAEKVLAL-------PEPSPAA 1087
Query: 478 RTHHRGRYAWASEEDDASSLTADNLEKFGKLSAF---PEPPEDGTLLSEAKL---QSIMS 531
T + + SL+A LEK +S + E+ E +L Q++ +
Sbjct: 1088 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1147
Query: 532 FLDEME--KSGQDQLDSQQEGWVPEAGP------GPLELGSEVSTSVMRLKLEVEE-KKQ 582
L E+E K+ +L +Q E P G E+G + +EVE +++
Sbjct: 1148 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1207
Query: 583 AMLLLQR--ALAQQRDLTARRVKETEKALSRQLQRQREHYE---ATIQRHLAFIDQL--- 634
LL+R A+ Q D+ R +++ L RQL+ RE + A +Q +Q+
Sbjct: 1208 VAQLLERWQAVLAQTDVRQRELEQ----LGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1263
Query: 635 -IEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLK--ELMSATEKARREK 691
+ D + + E+ A L +E +R E+V + Q + I +K EL T KA+ E
Sbjct: 1264 PLADSQAVREQLRQEQA-LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1322
Query: 692 WISEKTKKIKEVTVRGLEPEIQKLI--ARHKQEVRRLKSLHEAELLQSDERASQRCLRQA 749
++ KK K + G E IQ+ + H E+ L S + + ++ LR+
Sbjct: 1323 -VASPAKKPKVQS--GSESVIQEYVDLRTHYSELTTLTSQYIKFISET--------LRRM 1371
Query: 750 EELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAA 809
EE +E L +Q+R R+R L + + AL++QRQ +AE + QA
Sbjct: 1372 EE--------EERLAEQQRAEERER----LAEVEAALEKQRQ-----LAEAHAQAKAQAE 1414
Query: 810 RQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELE-----RQ 864
R E +EL+Q+++E R E ++Q+R Q EL L+Q E E RQ
Sbjct: 1415 R---EAKELQQRMQEEV-----VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1466
Query: 865 AWEAGRTR---KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES 921
A A R+R +EE ++ + E E R G + E++ + R E A ++ E+A
Sbjct: 1467 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA--- 1523
Query: 922 RIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQA 981
+RLR + + E Q+E +L R EAE R+K+RAL+ +
Sbjct: 1524 --ERLRRQVQDESQRKRQAEVELASRVK------AEAEA--------AREKQRALQALEE 1567
Query: 982 VNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTAL 1041
+ Q L Q + A E R A+AEL + +A E +++ +L
Sbjct: 1568 LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA----SFAEKTAQLERSL 1623
Query: 1042 ARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 1074
+ AV+ LR + E ++ E E+ R
Sbjct: 1624 QEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656
Score = 81.3 bits (199), Expect = 5e-15
Identities = 124/568 (21%), Positives = 251/568 (44%), Gaps = 71/568 (12%)
Query: 552 VPEAGPGPLELGSEVSTSVMRLK-------LEVEEKKQAMLLLQRALAQQRDLTAR--RV 602
+PE P L SE+ ++ +L+ + +E+ K L+++ + L A ++
Sbjct: 1080 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1139
Query: 603 KETE---------KALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELK 653
KE + +A L++ R EA A D+L ++V E+ + E
Sbjct: 1140 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV-GERLQQRHGERD 1198
Query: 654 QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARRE-KWISEKTKKIKEVTVRGLEPEI 712
E +R ERVAQ +++ + +++ T+ +RE + + + + +E +P
Sbjct: 1199 VEVERWRERVAQL-------LERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADP-- 1245
Query: 713 QKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERAR 772
+ Q+ RR + +A L +D +A + LRQ + L E++ER E + +E +R
Sbjct: 1246 ---LGAWLQDARRRQEQIQAMPL-ADSQAVREQLRQEQALLEEIERHGEKV--EECQRFA 1299
Query: 773 QRFQQHLEQEQWAL---QQQRQRLYSEVAEERERLGQQAARQR--------AELEELRQQ 821
+++ ++ + L + Q + + S + + + G ++ Q +EL L Q
Sbjct: 1300 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1359
Query: 822 LEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNR 881
+ S R + E E+ E+Q + L ++ LE +RQ EA K +A
Sbjct: 1360 YIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA----- 1413
Query: 882 EQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAEL------- 934
E+E +E ++ +++ V+ R EA A+ ++ +++ + +++LR EAE+
Sbjct: 1414 EREAKELQQRMQEE----VVRREEA--AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1467
Query: 935 SELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLA 994
E+S +++E ++ QL E + +G ++ E+A+A Q E L
Sbjct: 1468 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1527
Query: 995 QVIRQEFEDRLAASEEETRQAKAELATLQARQQL--ELEEVHRRVKTALARKEEAVSSLR 1052
+ ++ E + + A E + KAE + +Q+ LEE+ + + A R +A
Sbjct: 1528 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1587
Query: 1053 TQHEAAVKRADHLEELLEQHRRPTPSTK 1080
Q + A++ A E Q +R + + K
Sbjct: 1588 RQVQVALETAQRSAEAELQSKRASFAEK 1615
Score = 57.4 bits (137), Expect = 7e-08
Identities = 95/384 (24%), Positives = 157/384 (40%), Gaps = 62/384 (16%)
Query: 728 SLHEAELLQS------DERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQ 781
S H +LLQS +E QRC+ + +++R QLE + R R + L++
Sbjct: 989 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE--------TRTVHRLRLPLDK 1040
Query: 782 EQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGR 841
E QR + E E LG+ AR AE E++ E S +A T E G+
Sbjct: 1041 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1100
Query: 842 EEQERR----HQMELNTLKQQLELERQAWEAGRTRKEE--------AWLLNRE------- 882
EQ R + +L T+ + + A E R +E+ A L E
Sbjct: 1101 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1160
Query: 883 -------------QELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDK 929
LR+E+R ++ V RL+ E E+ E R+ +L ++
Sbjct: 1161 KLRAQAEAQQPTFDALRDELRGAQE-----VGERLQQRHGERDVEVERWRE-RVAQLLER 1214
Query: 930 YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKER----ALEDAQAVNEQ 985
++A L++ + +R+L++ +L+ A+ LQ R++E+ L D+QAV EQ
Sbjct: 1215 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1274
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ-QLELEEVHRRVKTALARK 1044
L E Q + +E E EE R AK + ++ + QL + + A+K
Sbjct: 1275 LRQE-----QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1329
Query: 1045 EEAVSSLRTQHEAAVKRADHLEEL 1068
+ S + + V H EL
Sbjct: 1330 PKVQSGSESVIQEYVDLRTHYSEL 1353
Score = 39.7 bits (91), Expect = 0.016
Identities = 96/429 (22%), Positives = 180/429 (41%), Gaps = 71/429 (16%)
Query: 627 HLAFIDQLIEDKKVLSE----KC-EAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELM 681
H+A +++ +K++ SE +C + +V +L+ E C E++ QA A + +++ L+
Sbjct: 401 HVAILER---EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR----LL 453
Query: 682 SATEKARREKWISEKTKKIKEVTVRGLEPEIQKLI-ARH---KQEVRRLKSLHEAELLQS 737
+A + +R + K + +R L ++Q L RH +Q RR+ LHE +
Sbjct: 454 AAGKVPQRAGEVERDLDKADSM-IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR 512
Query: 738 DERASQRCLRQAEELREQLEREKEALGQQ-ERERARQRFQQHLEQEQWALQQQRQRLYSE 796
E + A + + +++ ++ E E + R+ Q L W + Q + +E
Sbjct: 513 TEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA--WVEENQHRVDGAE 570
Query: 797 VAEERERLGQQAARQRA---ELEELRQQLEESSS---ALTRALRAEFEKGREEQERRHQM 850
+ + Q R +EE R ++E + S L+ A R + + ++
Sbjct: 571 WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 630
Query: 851 ELNTLKQQLE-LERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMA 909
LN+ K +L LE KE WL +E+E E D+ + + E+ A
Sbjct: 631 LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE--EVGFDWSDRNTNMTAKK-ESYSA 687
Query: 910 LAKEESEKAAESRIKRLRDKYEAELSE-------LEQSERKLQERCS------------- 949
L +E K E +IK L++ + L E +E + LQ + S
Sbjct: 688 LMRELELK--EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 745
Query: 950 -------ELKGQLGEAEGENLRLQGLVRQK------------ERALEDAQAVNEQLSSER 990
+ + EAEG+ +LQ +R+K E L+DAQ EQL+ +
Sbjct: 746 KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 805
Query: 991 SNLAQVIRQ 999
+L+ + ++
Sbjct: 806 GHLSGLAKR 814
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 150 bits (378), Expect = 8e-36
Identities = 208/868 (23%), Positives = 370/868 (42%), Gaps = 102/868 (11%)
Query: 252 RRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAK-------REEQ 304
RR+++ + E E+ + Q + QR R Q +RR R E Q + R EQ
Sbjct: 545 RREQLLKREEEKRLEQERRE----QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ 600
Query: 305 RQRSGEGTLLDLHQQKEAA--RRKAREEKARQARRAAIQELQQKRALRAQKASTAERGPP 362
R + E L+ +++E R + EE+ +Q ++ QE ++++ LR ++ E+
Sbjct: 601 RLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Query: 363 ENPRETRVPGM-------RQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSD 415
E R+ + QEL+ A + +K+ D
Sbjct: 661 REEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVY 720
Query: 416 SSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLP 475
S P Q+ R + + L+ EE H Q E++
Sbjct: 721 SRPRKQEGQRRRQEQEEKRRRRESELQWQE------------EERAHRQQQEEEQ----- 763
Query: 476 RPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPE--DGTLLSEAKLQSIMSFL 533
R + W + ++ S +LSA P E + L +E + Q FL
Sbjct: 764 ------RRDFTWQWQAEEKSERGRQ------RLSARPPLREQRERQLRAEERQQREQRFL 811
Query: 534 DEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQ 593
E E+ Q + ++ E + + +++ +++A L +
Sbjct: 812 PEEEEKEQRRRQRRER---------------EKELQFLEEEEQLQRRERAQQLQEEEDGL 856
Query: 594 QRDLTARRVKET--EKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAE 651
Q D RR +E ++ QL+ +R+ T+ A +QL +++++L E+ E + E
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916
Query: 652 LKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREK----WISEKTKKIKEVTVRG 707
++E +R E+ Q + + +L+ ++ + L EK RR++ + +K + KE + G
Sbjct: 917 -EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975
Query: 708 LEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELR--EQLEREKEALGQ 765
EPE ++ R K+ + E E L +ER +R + R ++L++E+E L +
Sbjct: 976 EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLR 1035
Query: 766 QERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEE- 824
+ERE+ R + ++ +E+ LQQ+ ++L E E R R Q+ RQ + EEL+Q+ E+
Sbjct: 1036 EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRR--QELERQYRKEEELQQEEEQL 1093
Query: 825 SSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 884
+ R E E+ E+E Q E L+++ E R+ + R+EE EQ
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153
Query: 885 LREEIRKGRDKEIELVIHRLE----ADMALAKEESEKAAESRIKRLRDKYEAELSELEQS 940
LREE K R +E+E E + L +EE EK + R ++ R++ E + + +Q
Sbjct: 1154 LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213
Query: 941 ERKLQERCSELKGQLGEAEGEN------LRLQGLVRQKERALEDAQAVNEQLSSERSNLA 994
R +R S+LK Q E E EN + +G ++ R LED+Q + Q + +L
Sbjct: 1214 YRDEDQR-SDLKWQ-WEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHL- 1270
Query: 995 QVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQ 1054
+ Q+ DR E+E R+ + +QLE EE + K + +E LR +
Sbjct: 1271 -LGEQQERDR----EQERRRWQQRDRHFPEEEQLEREE-QKEAKRRDRKSQEEKQLLREE 1324
Query: 1055 HEAAVKRAD-----HLEELLEQHRRPTP 1077
E +R + EE L Q R P
Sbjct: 1325 REEKRRRQETDRKFREEEQLLQEREEQP 1352
Score = 130 bits (328), Expect = 5e-30
Identities = 138/570 (24%), Positives = 256/570 (44%), Gaps = 74/570 (12%)
Query: 511 FPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSV 570
F E E E L+ L E E Q +L ++E ++
Sbjct: 238 FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL------------RKLERQE 285
Query: 571 MRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAF 630
+R + + EE++Q L ++ L ++++ R +E + + ++Q E E ++R
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQ-- 343
Query: 631 IDQLIEDKKVLSEKCEAVVAELKQEDQRCTE-RVAQAQAQHELEIKKLKELMSATEKARR 689
E+ E + ++E++R + R Q + + E ++++ ++L ++ RR
Sbjct: 344 -----------EERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE-QQLRR 391
Query: 690 EKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQA 749
E+ + + + +E +R + ++ R +Q++RR + E ER QR R+
Sbjct: 392 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ 451
Query: 750 EELREQLEREKEALGQQERERARQ--RFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQ 807
EE R+ L+RE+E ++ R +Q R Q+ +E+W ++ +R E++ER QQ
Sbjct: 452 EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER-----REQQERREQQ 506
Query: 808 AARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWE 867
R++ E E R + +E L + LR+E + RE++ERR Q+ +++LE ER
Sbjct: 507 LRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER---- 562
Query: 868 AGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLR 927
REQ L+ E + RD +L+ E K E E+ E R+KR
Sbjct: 563 -------------REQRLKREQEERRD---QLLKREEERRQQRLKREQEERLEQRLKR-- 604
Query: 928 DKYEAELSELEQSER-----KLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAV 982
E+ LEQ ER K +E E + QL ++E + R Q +R++++ + +
Sbjct: 605 ----EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Query: 983 NEQLSSERSNLAQVIRQEFED-----RLAASEEETRQAKAELATLQARQQLELEEVHRRV 1037
E+ E L Q +++E E+ LA E+E + + + + + QLE E R+
Sbjct: 661 REE---EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQS 717
Query: 1038 KT-ALARKEEAVSSLRTQHEAAVKRADHLE 1066
K + RK+E + Q E +R L+
Sbjct: 718 KVYSRPRKQEGQRRRQEQEEKRRRRESELQ 747
Score = 130 bits (327), Expect = 7e-30
Identities = 199/843 (23%), Positives = 357/843 (42%), Gaps = 100/843 (11%)
Query: 259 EEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLL---- 314
+E ER + + ++ R + ++R R + L + REE+ + E LL
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKR-----RRQELERQYREEEEVQQEEEQLLREEP 1158
Query: 315 DLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMR 374
+ +++E R+ EE+ +Q ++E Q+KR ++ E R+ R
Sbjct: 1159 EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED 1218
Query: 375 QPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQ 434
Q + +L A++ N ++ DS +Q +D Q +L +
Sbjct: 1219 QRS-DLKWQWEPEKENAVRDNKV---YCKGRENEQFRQLEDSQLRDRQSQQD-LQHLLGE 1273
Query: 435 DAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDA 494
D + R + R EE + LE+E + R +++
Sbjct: 1274 QQERDREQERR--RWQQRDRHFPEE-----EQLEREEQKEAKRRDR--------KSQEEK 1318
Query: 495 SSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPE 554
L + EK + + E+ LL E + Q + + +D+ ++E E
Sbjct: 1319 QLLREEREEKRRRQETDRKFREEEQLLQEREEQPL-------RRQERDRKFREEELRHQE 1371
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
G LE + K EE++ ++ L Q RD R+ +E E+ LSRQ +
Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD---RKFREEEQQLSRQER 1428
Query: 615 RQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEI 674
++ E R + +E+++ L ++ + ++E+Q ER Q + E +
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHR---KFREEEQLLQEREEQQLHRQERDR 1485
Query: 675 KKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQ---EVRRLKSLHE 731
K L+E ++ RR+ E+ +K +E +R EPE +K + +Q + R+ K L E
Sbjct: 1486 KFLEE----EQQLRRQ----ERDRKFREQELRSQEPE-RKFLEEEQQLHRQQRQRKFLQE 1536
Query: 732 AELLQSDERASQRC------LRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWA 785
+ L+ ER QR R+ E+LR+ ERE++ L +QER+R + LE+++
Sbjct: 1537 EQQLRRQERGQQRRQDRDRKFREEEQLRQ--EREEQQLSRQERDR-----KFRLEEQKVR 1589
Query: 786 LQQQRQRLYSEVAEERERLGQQAARQRAE--LEELRQQLEESSSALTRALRAEFEKGREE 843
Q+Q ++ + + R + GQQ RQ + E Q L+E R E + R+E
Sbjct: 1590 RQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQE---------REEQQLHRQE 1640
Query: 844 QERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNR--EQELREEIRKGRDKEIELVI 901
++R+ E L++Q ++ + R +EE LL EQ+LR + R + +E E +
Sbjct: 1641 RDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL 1700
Query: 902 HRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGE 961
R E + +EE + + ++ R++ + E EQ + + QER ++ E E
Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLR-QETEQEQLRRQERYRKI------LEEE 1753
Query: 962 NLRLQGLVRQKERALEDAQ-AVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELA 1020
LR + +Q R D + EQL ER Q +R + DR EE+ RQ + E
Sbjct: 1754 QLRPEREEQQLRRQERDRKFREEEQLRQEREE--QQLRSQESDRKFREEEQLRQEREEQQ 1811
Query: 1021 TLQAR---------QQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1071
+ +QL+LEE +R++ R+ A TQ E + + L + EQ
Sbjct: 1812 LRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQ-EKSRREEQELWQEEEQ 1870
Query: 1072 HRR 1074
RR
Sbjct: 1871 KRR 1873
Score = 125 bits (315), Expect = 2e-28
Identities = 217/907 (23%), Positives = 369/907 (40%), Gaps = 123/907 (13%)
Query: 214 KAATCEGSESSGFGKLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATV 273
K A C+G ES + + G RR++ +E ER + + + +
Sbjct: 99 KRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQK--RQEQERELAEGEEQSE 156
Query: 274 TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKE------------ 321
+R + QRR R Q +REE+R + H+ +E
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQ-EREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 322 -AARRKAREEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQEL 380
RRK REEK +Q R + Q++ +K T R E +E P ++ QE
Sbjct: 216 LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE-PQRQRELQEE 274
Query: 381 SPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDN 440
Q L+ + E QQ R + L + +
Sbjct: 275 EEQLRKLERQELR--------------------RERQEEEQQQQRLRREQQLRRKQEEER 314
Query: 441 LEMMAPSRGSAKSRGPLEELLHTLQLLEKE---PDVLPRPRTHHRGRYAWASEEDDASSL 497
E R + R EE E+E L R + R E+++
Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE--ER 372
Query: 498 TADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGP 557
L + +L + + L E +L+ E + + QL +Q
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ--------- 423
Query: 558 GPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEK--ALSRQLQR 615
+L E K E E ++Q L+R ++RD +R +ETE+ R+ Q
Sbjct: 424 ---QLRREQEEERHEQKHEQERREQR---LKREQEERRD-WLKREEETERHEQERRKQQL 476
Query: 616 QREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIK 675
+R+ E +R L + E+++ E+ E +L++E + E+ + Q + E
Sbjct: 477 KRDQEEERRERWLKLEE---EERREQQERRE---QQLRREQEERREQRLKRQEEEE---- 526
Query: 676 KLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELL 735
+L++ + + ++ RRE+ + + +K + LE E ++ + +QE RR + L
Sbjct: 527 RLQQRLRSEQQLRREQ-EERREQLLKREEEKRLEQERREQRLKREQEERR-----DQLLK 580
Query: 736 QSDERASQRCLRQAEE-LREQLEREK-EALGQQERERARQRFQQHLEQEQWALQQQRQRL 793
+ +ER QR R+ EE L ++L+RE+ E L Q+ER +Q L++E+ ++++Q L
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERR------EQRLKREEPEEERRQQLL 634
Query: 794 YSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQE-------- 845
SE E+ ER QQ R++ E E R + EE L + L+ E E+ R EQE
Sbjct: 635 KSE--EQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQ 692
Query: 846 RRHQMELNTLKQQLELE-----RQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELV 900
R +++ K Q +LE RQ+ R RK+E +EQE K R +E EL
Sbjct: 693 ARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQE-----EKRRRRESELQ 747
Query: 901 IHRLEADMALAKEESEK-------AAESRIKRLRDKYEAELSELEQSERKL--QERCSEL 951
E +EE ++ AE + +R R + A EQ ER+L +ER
Sbjct: 748 WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQRE 807
Query: 952 KGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEE 1011
+ L E E + R RQ+ ++ Q + E+ +R AQ +++E ED L ++E
Sbjct: 808 QRFLPEEEEKEQRR----RQRREREKELQFLEEEEQLQRRERAQQLQEE-EDGL-QEDQE 861
Query: 1012 TRQAKAELATLQARQQLELEEVHRR----VKTALARKEEAVSSLRTQHEAAVKRADHLEE 1067
R+++ + + R QLE E RR K AL + L + E ++R + +
Sbjct: 862 RRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKR 921
Query: 1068 LLEQHRR 1074
++ R
Sbjct: 922 RRQEQER 928
Score = 124 bits (310), Expect = 6e-28
Identities = 203/888 (22%), Positives = 366/888 (41%), Gaps = 112/888 (12%)
Query: 252 RRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEG 311
R++E+ EEE + + ++ + + +R Q Q+R R E L+ K+EE+R+ E
Sbjct: 267 RQRELQEEEEQ--LRKLERQELRRERQEEEQQQQR----LRREQQLRRKQEEERREQQE- 319
Query: 312 TLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVP 371
++++ RR+ +EE+ Q R +E ++++ R Q+ E+ E R
Sbjct: 320 -----ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374
Query: 372 GMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQ---QPPEDRT 428
+ Q+L Q L+ + E Q + E+R
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH 434
Query: 429 QDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWA 488
+ Q+ L+ R R EE Q E+ L R + R R W
Sbjct: 435 EQKHEQERREQRLKREQEERRDWLKRE--EETERHEQ--ERRKQQLKRDQEEER-RERWL 489
Query: 489 SEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQ 548
E++ + E+ +L E + L + + + + L + QL +Q
Sbjct: 490 KLEEEERREQQERREQ--QLRREQEERREQRLKRQEEEERLQQRL-----RSEQQLRREQ 542
Query: 549 EGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA 608
E + E E RLK E EE++ +L + QQ R +E E+
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQ-----RLKREQEER 597
Query: 609 LSRQLQRQR-EHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQ 667
L ++L+R+ E E +R +Q ++ ++ E+ + ++ +QE++R + + Q
Sbjct: 598 LEQRLKREEVERLEQEERR-----EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652
Query: 668 AQHELEIKKLKE-------LMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLI---- 716
+ E +K+ +E L E+ RRE+ ++E+ ++ ++ P+ Q +
Sbjct: 653 ERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEA 712
Query: 717 ----------------ARHKQEVRRLKSLHEAEL-LQSDERASQRCLRQAEELREQLERE 759
R +QE + E+EL Q +ERA ++ +Q EE R +
Sbjct: 713 DARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQ--QQEEEQRRDFTWQ 770
Query: 760 KEALGQQERERARQRFQ-----QHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAE 814
+A +++ ER RQR + + Q ++++QR + EE E+ +Q RQR E
Sbjct: 771 WQA--EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK--EQRRRQRRE 826
Query: 815 LEELRQQLEESSSALTR----ALRAEFEKGREEQERRHQMEL---NTLKQQLELERQAWE 867
E+ Q LEE R L+ E + +E+QERR E + QLE ER+
Sbjct: 827 REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRR 886
Query: 868 ---------AGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKA 918
+ RKE+ L E+EL+ E R+ R ++ + +R E L +EE +
Sbjct: 887 HTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQ--LQQEEEQLL 944
Query: 919 AESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALED 978
E R KR R + E + + ++KLQ++ +L G+ E R + ++E E+
Sbjct: 945 REEREKRRRQERERQY----RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEE 1000
Query: 979 AQAVNEQLSSERSNLAQVIRQEFE------DRLAASEEETRQAKAELATLQARQQLELEE 1032
Q + E+ R RQE+E D L EE+ + + E LQ R++ EE
Sbjct: 1001 EQLLREEREKRR-------RQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE 1053
Query: 1033 VHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1080
+ + EE + R + E ++ + L++ EQ R P +
Sbjct: 1054 EELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKR 1101
Score = 122 bits (307), Expect = 1e-27
Identities = 191/850 (22%), Positives = 348/850 (40%), Gaps = 102/850 (12%)
Query: 250 LPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
L R +++ E+ R Q+ + Q+ R Q RR R E + +R EQR +
Sbjct: 395 LRREQQLRREQQLRREQQLRRE----QQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450
Query: 310 EGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETR 369
+ D +++E R +E + +Q +R + +++R R K ER + RE +
Sbjct: 451 QEERRDWLKREEETERHEQERRKQQLKR----DQEEERRERWLKLEEEERREQQERREQQ 506
Query: 370 VPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQ 429
+ ++ +E Q LK +R S + ++ E+R +
Sbjct: 507 LRREQEERRE----------QRLKRQEEE---------ERLQQRLRSEQQLRREQEERRE 547
Query: 430 DVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWAS 489
+L ++ + + R + + EE + +L R + R
Sbjct: 548 QLLKREEE----KRLEQERREQRLKREQEE---------RRDQLLKREEERRQQRLKREQ 594
Query: 490 EEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQE 549
EE L + +E+ + + + E + Q + S +E E+ Q QL +Q+
Sbjct: 595 EERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKS--EEQEERRQQQLRREQQ 652
Query: 550 GWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKAL 609
E L+ E RLK E EE+++ L + Q R+ R+ + + L
Sbjct: 653 ----ERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQL 708
Query: 610 SRQLQ-RQREHYEATIQRHLAFIDQLIEDKKVLSE-----KCEAVVAELKQEDQRCTERV 663
+ RQ + Y ++ Q E+K+ E + E +QE+++ +
Sbjct: 709 ESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFT 768
Query: 664 AQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
Q QA+ + E + + + +RE+ + + ++ +E E E ++ + ++
Sbjct: 769 WQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE 828
Query: 724 RRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQ 783
+ L+ L E E LQ ERA +QL+ E++ L Q+++ER R + Q+ ++ +
Sbjct: 829 KELQFLEEEEQLQRRERA------------QQLQEEEDGL-QEDQERRRSQEQRRDQKWR 875
Query: 784 WALQQQRQR----LYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEK 839
W L+++R+R LY++ A + + +Q Q E E R++ E+ R E E+
Sbjct: 876 WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRR-------RQEQER 928
Query: 840 GREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIEL 899
E+E+ Q E L+++ E R+ + RK++ EQ L EE K R +E E
Sbjct: 929 QYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE- 987
Query: 900 VIHRLEADMALAKEESEKAAESRIKRLRDKYEAEL---SELEQSERKLQERCSELKGQLG 956
+ + L +EE + E R KR R ++E + EL+Q E QL
Sbjct: 988 --KKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEE-----------QLL 1034
Query: 957 EAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFE------DRLAASEE 1010
E E RLQ RQ R E+ Q EQL E + RQE E + L EE
Sbjct: 1035 REEREKRRLQERERQY-REEEELQQEEEQLLGEERETRR--RQELERQYRKEEELQQEEE 1091
Query: 1011 ETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLE 1070
+ + + E Q R++ EE + + +EE R + E + + +++ E
Sbjct: 1092 QLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEE 1151
Query: 1071 QHRRPTPSTK 1080
Q R P +
Sbjct: 1152 QLLREEPEKR 1161
Score = 114 bits (286), Expect = 4e-25
Identities = 139/549 (25%), Positives = 246/549 (44%), Gaps = 66/549 (12%)
Query: 577 VEEKKQAMLLLQRALAQQR--DLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQL 634
++E+K+A + +L Q R + RR + ++ L + ++R +R LA ++
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 635 IEDKKVLSEKCEAVVAE---------LKQEDQRCTERVAQAQAQHELEI------KKLKE 679
E ++ L ++ E ++E++R E Q+ HE E + +E
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 680 LMSATEKARREK-------------------WISEKTKKIKEVT-VRGLEPEIQKLIARH 719
L+ K R EK W +T KE ++ EP+ Q+ +
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE 274
Query: 720 KQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHL 779
++++R+L+ Q +E+ QR LR+ ++LR + E E+ ++ RE+ +R QQ
Sbjct: 275 EEQLRKLERQELRRERQEEEQQQQR-LRREQQLRRKQEEERREQQEERREQQERREQQEE 333
Query: 780 EQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRA--LRAEF 837
+EQ ++Q +R ++ E+E ++ +R + EE R+Q L R LR E
Sbjct: 334 RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQ 393
Query: 838 EKGREEQERRHQM--ELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDK 895
+ RE+Q RR Q L+++ +L R+ + R ++EE EQE RE+ K +
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQ-QLRREQEEERHEQKHEQERREQRLKREQE 452
Query: 896 EIELVIHRLEADMALAKEESEKAAESRIK-RLRDKYEAELSE----LEQSERKLQERCSE 950
E D +EE+E+ + R K +L+ E E E LE+ ER+ Q+ E
Sbjct: 453 E--------RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ---E 501
Query: 951 LKGQLGEAEGENLRLQGLVRQ-KERALEDAQAVNEQLSSER-SNLAQVIRQEFEDRLAAS 1008
+ Q E E R Q L RQ +E L+ +QL E+ Q++++E E RL
Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRL--- 558
Query: 1009 EEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEEL 1068
E+E R+ + + + R QL E RR + +EE + + E V+R + E
Sbjct: 559 EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE--VERLEQEERR 616
Query: 1069 LEQHRRPTP 1077
++ +R P
Sbjct: 617 EQRLKREEP 625
Score = 103 bits (258), Expect = 7e-22
Identities = 203/880 (23%), Positives = 362/880 (41%), Gaps = 128/880 (14%)
Query: 276 QRWYRHQVQRRGAGAARLEHLLQAKREEQ--RQRSGEGTLLDLHQQKEAARRKAREEKAR 333
QR + Q ++R R E LQ + EE+ RQ+ E D Q +A K+ + R
Sbjct: 729 QRRRQEQEEKR----RRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA-EEKSERGRQR 783
Query: 334 QARRAAIQELQQKRALRAQKASTAERG--PPENPRETRVPGMRQPAQELSPTPGGTAHQA 391
+ R ++E Q++R LRA++ E+ P E +E R R+ +EL Q
Sbjct: 784 LSARPPLRE-QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL---------QF 833
Query: 392 LKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSA 451
L+ L + D E Q+ R+Q+ LE R
Sbjct: 834 LEEEEQ---LQRRERAQQLQEEEDGLQEDQE--RRRSQEQRRDQKWRWQLEEERKRRRHT 888
Query: 452 KSRGPL--EELLHTLQLLEKEPDVLPRPRTHHRGRYAWASE-------EDDASSLTADNL 502
P E+L QLL++E + L R R R + + + L +
Sbjct: 889 LYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREER 948
Query: 503 EKFGKLSAFPEPPEDGTLLSEAKLQSIMSF------LDEMEKSGQDQLDSQQEGWVPEAG 556
EK + + +D L + K + ++ E EK +++ + QQE
Sbjct: 949 EKRRRQERERQYRKDKKL--QQKEEQLLGEEPEKRRRQEREKKYREEEELQQE------- 999
Query: 557 PGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQ 616
+L E R + E + +K+ L + + + RR++E E+ + + Q
Sbjct: 1000 --EEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQ 1057
Query: 617 REHY----EATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHEL 672
+E E R +++ ++ L ++ E ++ E + E +R ER Q + + EL
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE-EPEKRRRQERERQCREEEEL 1116
Query: 673 EIKKLKELMSATEKARREK----WISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKS 728
+ ++ + L EK RR++ + E+ + +E + EPE R +QE+ R +
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPE-----KRRRQELER-QY 1170
Query: 729 LHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQER-ERARQRFQQHLEQEQWALQ 787
E EL Q +E+ + + + RE+ RE+E L +Q+R +R R Q+ + QW +
Sbjct: 1171 REEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPE 1230
Query: 788 QQR----QRLYSEVAEE-----------RER---------LGQQAARQRAELEELRQQLE 823
++ ++Y + E R+R LG+Q R R E E R Q
Sbjct: 1231 KENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDR-EQERRRWQQR 1289
Query: 824 ESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLN--- 880
+ L E +K + ++R+ Q E L+++ E +R+ E R +EE LL
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE 1349
Query: 881 -------------REQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLR 927
RE+ELR + + + E E + R E + KEE + + R ++LR
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLR 1409
Query: 928 D----KYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQ-KERALEDAQAV 982
K+ E +L + ER + R E + + E E + L + +RQ + R +
Sbjct: 1410 QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE---- 1465
Query: 983 NEQLSSERSNLAQVIRQEFEDRLAASEEETRQ-------AKAELATLQARQQL--ELEEV 1033
EQL ER Q+ RQE + + E++ R+ + EL + + ++ E +++
Sbjct: 1466 EEQLLQEREE-QQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524
Query: 1034 HRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHR 1073
HR+ + +EE LR Q +R D + E+ +
Sbjct: 1525 HRQQRQRKFLQEE--QQLRRQERGQQRRQDRDRKFREEEQ 1562
Score = 87.4 bits (215), Expect = 6e-17
Identities = 175/799 (21%), Positives = 314/799 (39%), Gaps = 122/799 (15%)
Query: 189 RYTPSERAPPLKSSNQTAPSLNNIIK--AATCEGSESSGFGKLPKNVSSATHSARNNTGG 246
RY ++ LK Q P N ++ C+G E+ F +L S ++
Sbjct: 1213 RYRDEDQRSDLKW--QWEPEKENAVRDNKVYCKGRENEQFRQLE---DSQLRDRQSQQDL 1267
Query: 247 STGLPRRKEVTEEEAERFIHQVNQ---ATVTIQRWYRHQVQRRGAGAARLEHLLQAKREE 303
L ++E E+ R Q ++ ++R + + +RR + + LL+ +REE
Sbjct: 1268 QHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREE 1327
Query: 304 QRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA-IQELQQKRALRAQKASTAERGPP 362
+R+R +E R+ EE+ Q R ++ ++ R R ++ E+G
Sbjct: 1328 KRRR------------QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK 1375
Query: 363 ENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQ 422
E R+ + + L Q L+ L DR + + +
Sbjct: 1376 FLEEEQRLRRQERERKFLKE------EQQLRCQEREQQLRQ----DRDRKFREEEQQLSR 1425
Query: 423 PPEDRT-----QDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRP 477
DR Q V Q+ LE R + EE L L E+E L R
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL----LQEREEQQLHRQ 1481
Query: 478 RTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKL---QSIMSFLD 534
+ + EE D KF + + PE L E +L Q FL
Sbjct: 1482 ERDRK----FLEEEQQLRRQERDR--KFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQ 1535
Query: 535 EMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQ 594
E + QL Q+ G + K EE+ + Q+ Q+
Sbjct: 1536 E-----EQQLRRQERG--------------QQRRQDRDRKFREEEQLRQEREEQQLSRQE 1576
Query: 595 RDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQ 654
RD R+ + E+ + RQ Q ++ + R QL +++ + ++
Sbjct: 1577 RD---RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD----------RKFRE 1623
Query: 655 EDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQK 714
++Q ER Q + E + K L+E + R ++ ++ +K +E E E Q+
Sbjct: 1624 DEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQ 1683
Query: 715 L--------IARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQ 766
L +Q++RR + E + LQ +++ ++ L + EQL +E E Q
Sbjct: 1684 LRRQERDRKFREEEQQLRRQE--RERKFLQEEQQLRRQELERKFREEEQLRQETE----Q 1737
Query: 767 ERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESS 826
E+ R ++R+++ LE+EQ +++ Q+L +ER+R ++ + R E EE + + +ES
Sbjct: 1738 EQLRRQERYRKILEEEQLRPEREEQQLR---RQERDRKFREEEQLRQEREEQQLRSQESD 1794
Query: 827 SALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELR 886
K REE++ R + E L+ Q + WE +E+ L +EQ LR
Sbjct: 1795 -----------RKFREEEQLRQEREEQQLRPQQRDGKYRWE-----EEQLQLEEQEQRLR 1838
Query: 887 EEIRKGRDKEIELVIHR--LEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKL 944
+E + E + + L +EE +K + R ++LR+++ + EQ R++
Sbjct: 1839 QERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQV 1898
Query: 945 QERCSELKGQLGEAEGENL 963
E+K Q G+ G L
Sbjct: 1899 ----GEIKSQEGKGHGRLL 1913
Score = 78.6 bits (192), Expect = 3e-14
Identities = 109/427 (25%), Positives = 196/427 (45%), Gaps = 56/427 (13%)
Query: 600 RRVKETEKALSRQLQRQRE---------HYEATIQRHLAFIDQLIEDKKVLSEKCEAVVA 650
R+ E E+ L RQ QRQR+ E QR + E++++ E+ E ++
Sbjct: 1515 RKFLEEEQQLHRQ-QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573
Query: 651 ELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEP 710
+QE R Q + E E K +++ + +++ E+ +K +E E
Sbjct: 1574 --RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER 1631
Query: 711 EIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERER 770
E Q+L H+QE R K L E L+ ER Q + + RE+ + +E G++++ R
Sbjct: 1632 EEQQL---HRQE-RDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE--GEEQQLR 1685
Query: 771 ARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALT 830
++R ++ E+EQ +Q+R+R + + EE++ Q+ R+ E E+LRQ+ E+ L
Sbjct: 1686 RQERDRKFREEEQQLRRQERERKFLQ--EEQQLRRQELERKFREEEQLRQETEQEQ--LR 1741
Query: 831 RALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELR--EE 888
R R + K EE++ R + E L++Q E +R+ E + R+E EQ+LR E
Sbjct: 1742 RQER--YRKILEEEQLRPEREEQQLRRQ-ERDRKFREEEQLRQER-----EEQQLRSQES 1793
Query: 889 IRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLR-DKYEAELSELEQSERKLQER 947
RK R++E + +EE + + R + R ++ + +L E EQ R QER
Sbjct: 1794 DRKFREEE----------QLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ--RLRQER 1841
Query: 948 CSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAA 1007
+ + + + Q++ E+ + E+ R + +R+E R
Sbjct: 1842 DRQYRAE-----------EQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQK 1890
Query: 1008 SEEETRQ 1014
E+ RQ
Sbjct: 1891 EEQRHRQ 1897
Score = 73.6 bits (179), Expect = 1e-12
Identities = 85/331 (25%), Positives = 142/331 (42%), Gaps = 46/331 (13%)
Query: 761 EALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQ 820
+A G E +RAR ++ L Q++ Q++ QR + E R+R ++ QR RQ
Sbjct: 91 QATGLDEEKRARCDGKESLLQDR--RQEEDQRRF----EPRDRQLEEEPGQRR-----RQ 139
Query: 821 QLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLN 880
+ +E L AE E+ E+QER Q + ++L +RQ W+ R+ E L
Sbjct: 140 KRQEQEREL-----AEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQ 194
Query: 881 ----------------REQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIK 924
R +EL E RKGR+++ + R E + +EE EK R
Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQ---QRRERQDRVFQEEEEKEWRKRET 251
Query: 925 RLRDKYEAELSELEQSERKLQERCSELK----------GQLGEAEGENLRLQGLVRQKER 974
LR + E E Q +R+LQE +L+ Q E + + LR + +R+K+
Sbjct: 252 VLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE 311
Query: 975 ALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVH 1034
E + E+ + Q R+E + R E +Q + E + QQL E+
Sbjct: 312 E-ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370
Query: 1035 RRVKTALARKEEAVSSLRTQHEAAVKRADHL 1065
R + L R+++ + + E ++R L
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQL 401
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 117 bits (292), Expect = 8e-26
Identities = 218/806 (27%), Positives = 326/806 (40%), Gaps = 121/806 (15%)
Query: 328 REEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGT 387
R+++ QAR +Q++Q+ Q+ S E G + RV + + L+
Sbjct: 874 RQDEVLQARAQELQKVQE-----LQQQSAREVGELQG----RVAQLEEERARLAEQLRAE 924
Query: 388 AHQALKANNTGGGLPA---------------AGPGDRCLPTSDSSPEP-QQPPEDRTQDV 431
A +A T G L A G + C + + QQ ++ +
Sbjct: 925 AELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHL 984
Query: 432 LAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAW---- 487
A++ A L++ + AK + E+LL LLE + L + R R A
Sbjct: 985 EAEEGARQKLQLEKVTT-EAKMKKFEEDLL----LLEDQNSKLSKERKLLEDRLAEFSSQ 1039
Query: 488 -ASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEA---KLQSIMSFLDEMEKSGQDQ 543
A EE+ SL L K A ED E +L+ + LD Q+Q
Sbjct: 1040 AAEEEEKVKSLNKLRL----KYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQ 1095
Query: 544 LDSQQEGWVPEAGPGPLELG---SEVSTSVMRLKLEVEEKKQAMLLL---QRALAQ-QRD 596
+ QQ+ A +LG E+ ++ R + E + Q + L Q ALA+ Q D
Sbjct: 1096 MVEQQQ----RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1151
Query: 597 LTARRVKETE-----KALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAE 651
L + RV T+ + L +L+ R E T+ A ++ L K E V E
Sbjct: 1152 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNA--------QQELRSKREQEVTE 1203
Query: 652 LK---QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGL 708
LK +E+ R E Q Q + L EL E+ARR K EKT+ E V L
Sbjct: 1204 LKKTLEEETRIHEAAVQELRQRHGQA--LGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1261
Query: 709 EPEIQKL-IARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEE--LREQLEREKEALGQ 765
E+ L AR + E RR + + + +Q +R +A E R Q E E +
Sbjct: 1262 RAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGAL 1321
Query: 766 QERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEES 825
E E R + L + A Q L E + LG + AE LR+QLEE
Sbjct: 1322 NEAESKTIRLSKELSSTE-AQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1380
Query: 826 SSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQEL 885
++A RA GRE Q Q +L+ +++ E E A EAG EEA R +
Sbjct: 1381 AAARERA-------GRELQTA--QAQLSEWRRRQEEEAGALEAG----EEA----RRRAA 1423
Query: 886 RE-EIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKL 944
RE E R E + RLE ++E + A ++ +S LE+ +RK
Sbjct: 1424 REAEALTQRLAEKTETVDRLERGRRRLQQELDDATMD-----LEQQRQLVSTLEKKQRKF 1478
Query: 945 QERCSELKGQLGEAEGENLRLQGLVRQKE-------RALEDAQAVNEQLSSERSNLAQVI 997
+ +E K + A E R + R++E RALE+ Q E+L ER N A +
Sbjct: 1479 DQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREEL--ERQNRA--L 1534
Query: 998 RQEFEDRLAASEE--------ETRQAKAELATLQARQQL-ELEEVHRRVKTALARKEEAV 1048
R E E L++ ++ E AE A R Q+ ELE+ + A R E V
Sbjct: 1535 RAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTV 1594
Query: 1049 SSLRTQHEAAVKRADHLEELLEQHRR 1074
+L+TQHE ++ D E E+ RR
Sbjct: 1595 QALKTQHERDLQGRD---EAGEERRR 1617
Score = 100 bits (248), Expect = 1e-20
Identities = 192/818 (23%), Positives = 333/818 (40%), Gaps = 122/818 (14%)
Query: 298 QAKREEQRQRSGEGTLLDLHQQKEAARR-KAREEKARQARRAAIQELQQKRALRAQKAST 356
+A +E RQR G+ L +L +Q E ARR K EK R A A + EL RA + +
Sbjct: 1216 EAAVQELRQRHGQA-LGELAEQLEQARRGKGAWEKTRLALEAEVSEL---RAELSSLQTA 1271
Query: 357 AERGPPENPR-ETRVPGMRQPAQELSPTPGGTAHQALKAN----NTGGGLPAAGPGDRCL 411
+ G R E ++ ++ A + A + +A N G L A L
Sbjct: 1272 RQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRL 1331
Query: 412 PTSDSSPEPQ--QPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEK 469
SS E Q E ++ A+ A G + M A++ G E+L
Sbjct: 1332 SKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM-----EAEAAGLREQL--------- 1377
Query: 470 EPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSI 529
E + R R + A A S E+ G L A E +EA Q +
Sbjct: 1378 EEEAAARERAGRELQTAQAQ----LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRL 1433
Query: 530 MSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQR 589
+ +++ + + QQE ++L + R + EKKQ +
Sbjct: 1434 AEKTETVDRLERGRRRLQQE-----LDDATMDLEQQ------RQLVSTLEKKQRKF--DQ 1480
Query: 590 ALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVV 649
LA+++ R V+E E+A + R+RE ++ R L ++ E ++ L + A+
Sbjct: 1481 LLAEEKAAVLRAVEERERAEAEG--REREARALSLTRAL---EEEQEAREELERQNRALR 1535
Query: 650 AELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLE 709
AEL + + + ++ HELE R ++E+ V LE
Sbjct: 1536 AEL---EALLSSKDDVGKSVHELE---------------RACRVAEQAANDLRAQVTELE 1577
Query: 710 PEI---QKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELRE-QLEREKEALGQ 765
E+ + R + V+ LK+ HE +L DE +R + A++LR+ ++ER++E +
Sbjct: 1578 DELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQR 1637
Query: 766 QERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEES 825
AR++ + LE+ L+ Q + + +E +Q + +A+++EL +++EE
Sbjct: 1638 TLAVAARKKLEGELEE----LKAQM----ASAGQGKEEAVKQLRKMQAQMKELWREVEE- 1688
Query: 826 SSALTRALRAE-FEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 884
TR R E F + RE ++R +E L+ Q EL + R R++ E
Sbjct: 1689 ----TRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAA----SDRARRQAQ---QDRDE 1737
Query: 885 LREEIRKGRDKEIELVIHRLEADMALAKEESEKAAE-SRIKRLRDKYE----------AE 933
+ +E+ G + ++ + + + L + E E E S + L D+Y E
Sbjct: 1738 MADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTE 1797
Query: 934 LS-------ELEQSERKLQERCSELKGQLGEAE-GENLRLQGLVRQKERALEDAQAVNEQ 985
LS + E ++L+ + EL+G+LGE + G R + + E L A+ EQ
Sbjct: 1798 LSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQ 1857
Query: 986 LSSER-----------SNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQL-ELEEV 1033
+ ER L +V+ Q E+R A + + K L Q ++QL E EE
Sbjct: 1858 ETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEE 1917
Query: 1034 HRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1071
R + R + + + E+ + L L +
Sbjct: 1918 ASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1955
Score = 77.8 bits (190), Expect = 5e-14
Identities = 183/816 (22%), Positives = 323/816 (39%), Gaps = 175/816 (21%)
Query: 231 KNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGA 290
+NVS A + A + T + E +A+ + + +A + + R
Sbjct: 1315 ENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLR 1374
Query: 291 ARLEHLLQAKREEQRQ-RSGEGTLLDLH--QQKEAARRKAREEKARQARRAAIQELQQKR 347
+LE A+ R+ ++ + L + Q++EA +A EE R+A R A + L Q+
Sbjct: 1375 EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREA-EALTQRL 1433
Query: 348 ALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPG 407
A + + ER G R+ QEL Q
Sbjct: 1434 AEKTETVDRLER------------GRRRLQQELDDATMDLEQQRQLV------------- 1468
Query: 408 DRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLL 467
S+ E +Q D+ +LA++ A + R A+ R L + L
Sbjct: 1469 --------STLEKKQRKFDQ---LLAEEKAAVLRAVEERERAEAEGREREARALSLTRAL 1517
Query: 468 EKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQ 527
E+E + +R A E +A + D++ K E ++E
Sbjct: 1518 EEEQEAREELERQNRALRA----ELEALLSSKDDVGK------SVHELERACRVAEQAAN 1567
Query: 528 SIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLL 587
+ + + E+E D+L + ++ + + +V LK + E Q
Sbjct: 1568 DLRAQVTELE----DELTAAEDAKL------------RLEVTVQALKTQHERDLQGR--- 1608
Query: 588 QRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEA 647
A ++R A+++++ E ++R E + T+ + +K L + E
Sbjct: 1609 DEAGEERRRQLAKQLRDAE------VERDEERKQRTL---------AVAARKKLEGELEE 1653
Query: 648 VVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRG 707
+ A++ Q E V Q + ++KEL E+ R +
Sbjct: 1654 LKAQMASAGQGKEEAVKQLRKMQ----AQMKELWREVEETRTSR---------------- 1693
Query: 708 LEPEIQKLIARHKQEVRRLKSLHEAELLQSDER--ASQRCLRQAEELREQLERE------ 759
+++ +++++ +RLK L EAE+L+ E AS R RQA++ R+++ E
Sbjct: 1694 -----EEIFSQNRESEKRLKGL-EAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNL 1747
Query: 760 -KEALGQQER--ERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQR---A 813
K A+ +++R E + ++ LE+EQ + R Y ++ + E L + + +R A
Sbjct: 1748 SKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDR-YRKLLLQVESLTTELSAERSFSA 1806
Query: 814 ELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRK 873
+ E RQQLE L L E R RH+M + L+ +L QA E
Sbjct: 1807 KAESGRQQLERQIQELRGRLGEEDAGAR----ARHKMTIAALESKL---AQAEE------ 1853
Query: 874 EEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAE 933
EQE RE I G K + RL+ ++ L EE + A+ +LRD+ E
Sbjct: 1854 ------QLEQETRERILSG--KLVRRAEKRLK-EVVLQVEEERRVAD----QLRDQLE-- 1898
Query: 934 LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALED----AQAVNEQLSSE 989
K R +LK QL EAE E R Q R+ +R LED A+++N ++++
Sbjct: 1899 ---------KGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTL 1949
Query: 990 RSNL--------AQVIRQEFE-DRLAASEEETRQAK 1016
R+ L + +RQ F + AS+EE +A+
Sbjct: 1950 RNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 1985
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 117 bits (292), Expect = 8e-26
Identities = 218/806 (27%), Positives = 326/806 (40%), Gaps = 121/806 (15%)
Query: 328 REEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGT 387
R+++ QAR +Q++Q+ Q+ S E G + RV + + L+
Sbjct: 866 RQDEVLQARAQELQKVQE-----LQQQSAREVGELQG----RVAQLEEERARLAEQLRAE 916
Query: 388 AHQALKANNTGGGLPA---------------AGPGDRCLPTSDSSPEP-QQPPEDRTQDV 431
A +A T G L A G + C + + QQ ++ +
Sbjct: 917 AELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHL 976
Query: 432 LAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAW---- 487
A++ A L++ + AK + E+LL LLE + L + R R A
Sbjct: 977 EAEEGARQKLQLEKVTT-EAKMKKFEEDLL----LLEDQNSKLSKERKLLEDRLAEFSSQ 1031
Query: 488 -ASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEA---KLQSIMSFLDEMEKSGQDQ 543
A EE+ SL L K A ED E +L+ + LD Q+Q
Sbjct: 1032 AAEEEEKVKSLNKLRL----KYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQ 1087
Query: 544 LDSQQEGWVPEAGPGPLELG---SEVSTSVMRLKLEVEEKKQAMLLL---QRALAQ-QRD 596
+ QQ+ A +LG E+ ++ R + E + Q + L Q ALA+ Q D
Sbjct: 1088 MVEQQQ----RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1143
Query: 597 LTARRVKETE-----KALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAE 651
L + RV T+ + L +L+ R E T+ A ++ L K E V E
Sbjct: 1144 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNA--------QQELRSKREQEVTE 1195
Query: 652 LK---QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGL 708
LK +E+ R E Q Q + L EL E+ARR K EKT+ E V L
Sbjct: 1196 LKKTLEEETRIHEAAVQELRQRHGQA--LGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1253
Query: 709 EPEIQKL-IARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEE--LREQLEREKEALGQ 765
E+ L AR + E RR + + + +Q +R +A E R Q E E +
Sbjct: 1254 RAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGAL 1313
Query: 766 QERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEES 825
E E R + L + A Q L E + LG + AE LR+QLEE
Sbjct: 1314 NEAESKTIRLSKELSSTE-AQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1372
Query: 826 SSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQEL 885
++A RA GRE Q Q +L+ +++ E E A EAG EEA R +
Sbjct: 1373 AAARERA-------GRELQTA--QAQLSEWRRRQEEEAGALEAG----EEA----RRRAA 1415
Query: 886 RE-EIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKL 944
RE E R E + RLE ++E + A ++ +S LE+ +RK
Sbjct: 1416 REAEALTQRLAEKTETVDRLERGRRRLQQELDDATMD-----LEQQRQLVSTLEKKQRKF 1470
Query: 945 QERCSELKGQLGEAEGENLRLQGLVRQKE-------RALEDAQAVNEQLSSERSNLAQVI 997
+ +E K + A E R + R++E RALE+ Q E+L ER N A +
Sbjct: 1471 DQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREEL--ERQNRA--L 1526
Query: 998 RQEFEDRLAASEE--------ETRQAKAELATLQARQQL-ELEEVHRRVKTALARKEEAV 1048
R E E L++ ++ E AE A R Q+ ELE+ + A R E V
Sbjct: 1527 RAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTV 1586
Query: 1049 SSLRTQHEAAVKRADHLEELLEQHRR 1074
+L+TQHE ++ D E E+ RR
Sbjct: 1587 QALKTQHERDLQGRD---EAGEERRR 1609
Score = 100 bits (248), Expect = 1e-20
Identities = 192/818 (23%), Positives = 333/818 (40%), Gaps = 122/818 (14%)
Query: 298 QAKREEQRQRSGEGTLLDLHQQKEAARR-KAREEKARQARRAAIQELQQKRALRAQKAST 356
+A +E RQR G+ L +L +Q E ARR K EK R A A + EL RA + +
Sbjct: 1208 EAAVQELRQRHGQA-LGELAEQLEQARRGKGAWEKTRLALEAEVSEL---RAELSSLQTA 1263
Query: 357 AERGPPENPR-ETRVPGMRQPAQELSPTPGGTAHQALKAN----NTGGGLPAAGPGDRCL 411
+ G R E ++ ++ A + A + +A N G L A L
Sbjct: 1264 RQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRL 1323
Query: 412 PTSDSSPEPQ--QPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEK 469
SS E Q E ++ A+ A G + M A++ G E+L
Sbjct: 1324 SKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM-----EAEAAGLREQL--------- 1369
Query: 470 EPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSI 529
E + R R + A A S E+ G L A E +EA Q +
Sbjct: 1370 EEEAAARERAGRELQTAQAQ----LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRL 1425
Query: 530 MSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQR 589
+ +++ + + QQE ++L + R + EKKQ +
Sbjct: 1426 AEKTETVDRLERGRRRLQQE-----LDDATMDLEQQ------RQLVSTLEKKQRKF--DQ 1472
Query: 590 ALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVV 649
LA+++ R V+E E+A + R+RE ++ R L ++ E ++ L + A+
Sbjct: 1473 LLAEEKAAVLRAVEERERAEAEG--REREARALSLTRAL---EEEQEAREELERQNRALR 1527
Query: 650 AELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLE 709
AEL + + + ++ HELE R ++E+ V LE
Sbjct: 1528 AEL---EALLSSKDDVGKSVHELE---------------RACRVAEQAANDLRAQVTELE 1569
Query: 710 PEI---QKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELRE-QLEREKEALGQ 765
E+ + R + V+ LK+ HE +L DE +R + A++LR+ ++ER++E +
Sbjct: 1570 DELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQR 1629
Query: 766 QERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEES 825
AR++ + LE+ L+ Q + + +E +Q + +A+++EL +++EE
Sbjct: 1630 TLAVAARKKLEGELEE----LKAQM----ASAGQGKEEAVKQLRKMQAQMKELWREVEE- 1680
Query: 826 SSALTRALRAE-FEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 884
TR R E F + RE ++R +E L+ Q EL + R R++ E
Sbjct: 1681 ----TRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAA----SDRARRQAQ---QDRDE 1729
Query: 885 LREEIRKGRDKEIELVIHRLEADMALAKEESEKAAE-SRIKRLRDKYE----------AE 933
+ +E+ G + ++ + + + L + E E E S + L D+Y E
Sbjct: 1730 MADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTE 1789
Query: 934 LS-------ELEQSERKLQERCSELKGQLGEAE-GENLRLQGLVRQKERALEDAQAVNEQ 985
LS + E ++L+ + EL+G+LGE + G R + + E L A+ EQ
Sbjct: 1790 LSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQ 1849
Query: 986 LSSER-----------SNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQL-ELEEV 1033
+ ER L +V+ Q E+R A + + K L Q ++QL E EE
Sbjct: 1850 ETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEE 1909
Query: 1034 HRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1071
R + R + + + E+ + L L +
Sbjct: 1910 ASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1947
Score = 77.8 bits (190), Expect = 5e-14
Identities = 183/816 (22%), Positives = 323/816 (39%), Gaps = 175/816 (21%)
Query: 231 KNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGA 290
+NVS A + A + T + E +A+ + + +A + + R
Sbjct: 1307 ENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLR 1366
Query: 291 ARLEHLLQAKREEQRQ-RSGEGTLLDLH--QQKEAARRKAREEKARQARRAAIQELQQKR 347
+LE A+ R+ ++ + L + Q++EA +A EE R+A R A + L Q+
Sbjct: 1367 EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREA-EALTQRL 1425
Query: 348 ALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPG 407
A + + ER G R+ QEL Q
Sbjct: 1426 AEKTETVDRLER------------GRRRLQQELDDATMDLEQQRQLV------------- 1460
Query: 408 DRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLL 467
S+ E +Q D+ +LA++ A + R A+ R L + L
Sbjct: 1461 --------STLEKKQRKFDQ---LLAEEKAAVLRAVEERERAEAEGREREARALSLTRAL 1509
Query: 468 EKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQ 527
E+E + +R A E +A + D++ K E ++E
Sbjct: 1510 EEEQEAREELERQNRALRA----ELEALLSSKDDVGK------SVHELERACRVAEQAAN 1559
Query: 528 SIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLL 587
+ + + E+E D+L + ++ + + +V LK + E Q
Sbjct: 1560 DLRAQVTELE----DELTAAEDAKL------------RLEVTVQALKTQHERDLQGR--- 1600
Query: 588 QRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEA 647
A ++R A+++++ E ++R E + T+ + +K L + E
Sbjct: 1601 DEAGEERRRQLAKQLRDAE------VERDEERKQRTL---------AVAARKKLEGELEE 1645
Query: 648 VVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRG 707
+ A++ Q E V Q + ++KEL E+ R +
Sbjct: 1646 LKAQMASAGQGKEEAVKQLRKMQ----AQMKELWREVEETRTSR---------------- 1685
Query: 708 LEPEIQKLIARHKQEVRRLKSLHEAELLQSDER--ASQRCLRQAEELREQLERE------ 759
+++ +++++ +RLK L EAE+L+ E AS R RQA++ R+++ E
Sbjct: 1686 -----EEIFSQNRESEKRLKGL-EAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNL 1739
Query: 760 -KEALGQQER--ERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQR---A 813
K A+ +++R E + ++ LE+EQ + R Y ++ + E L + + +R A
Sbjct: 1740 SKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDR-YRKLLLQVESLTTELSAERSFSA 1798
Query: 814 ELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRK 873
+ E RQQLE L L E R RH+M + L+ +L QA E
Sbjct: 1799 KAESGRQQLERQIQELRGRLGEEDAGAR----ARHKMTIAALESKL---AQAEE------ 1845
Query: 874 EEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAE 933
EQE RE I G K + RL+ ++ L EE + A+ +LRD+ E
Sbjct: 1846 ------QLEQETRERILSG--KLVRRAEKRLK-EVVLQVEEERRVAD----QLRDQLE-- 1890
Query: 934 LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALED----AQAVNEQLSSE 989
K R +LK QL EAE E R Q R+ +R LED A+++N ++++
Sbjct: 1891 ---------KGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTL 1941
Query: 990 RSNL--------AQVIRQEFE-DRLAASEEETRQAK 1016
R+ L + +RQ F + AS+EE +A+
Sbjct: 1942 RNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 1977
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 117 bits (292), Expect = 8e-26
Identities = 218/806 (27%), Positives = 326/806 (40%), Gaps = 121/806 (15%)
Query: 328 REEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGT 387
R+++ QAR +Q++Q+ Q+ S E G + RV + + L+
Sbjct: 907 RQDEVLQARAQELQKVQE-----LQQQSAREVGELQG----RVAQLEEERARLAEQLRAE 957
Query: 388 AHQALKANNTGGGLPA---------------AGPGDRCLPTSDSSPEP-QQPPEDRTQDV 431
A +A T G L A G + C + + QQ ++ +
Sbjct: 958 AELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHL 1017
Query: 432 LAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAW---- 487
A++ A L++ + AK + E+LL LLE + L + R R A
Sbjct: 1018 EAEEGARQKLQLEKVTT-EAKMKKFEEDLL----LLEDQNSKLSKERKLLEDRLAEFSSQ 1072
Query: 488 -ASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEA---KLQSIMSFLDEMEKSGQDQ 543
A EE+ SL L K A ED E +L+ + LD Q+Q
Sbjct: 1073 AAEEEEKVKSLNKLRL----KYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQ 1128
Query: 544 LDSQQEGWVPEAGPGPLELG---SEVSTSVMRLKLEVEEKKQAMLLL---QRALAQ-QRD 596
+ QQ+ A +LG E+ ++ R + E + Q + L Q ALA+ Q D
Sbjct: 1129 MVEQQQ----RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1184
Query: 597 LTARRVKETE-----KALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAE 651
L + RV T+ + L +L+ R E T+ A ++ L K E V E
Sbjct: 1185 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNA--------QQELRSKREQEVTE 1236
Query: 652 LK---QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGL 708
LK +E+ R E Q Q + L EL E+ARR K EKT+ E V L
Sbjct: 1237 LKKTLEEETRIHEAAVQELRQRHGQA--LGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1294
Query: 709 EPEIQKL-IARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEE--LREQLEREKEALGQ 765
E+ L AR + E RR + + + +Q +R +A E R Q E E +
Sbjct: 1295 RAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGAL 1354
Query: 766 QERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEES 825
E E R + L + A Q L E + LG + AE LR+QLEE
Sbjct: 1355 NEAESKTIRLSKELSSTE-AQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1413
Query: 826 SSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQEL 885
++A RA GRE Q Q +L+ +++ E E A EAG EEA R +
Sbjct: 1414 AAARERA-------GRELQTA--QAQLSEWRRRQEEEAGALEAG----EEA----RRRAA 1456
Query: 886 RE-EIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKL 944
RE E R E + RLE ++E + A ++ +S LE+ +RK
Sbjct: 1457 REAEALTQRLAEKTETVDRLERGRRRLQQELDDATMD-----LEQQRQLVSTLEKKQRKF 1511
Query: 945 QERCSELKGQLGEAEGENLRLQGLVRQKE-------RALEDAQAVNEQLSSERSNLAQVI 997
+ +E K + A E R + R++E RALE+ Q E+L ER N A +
Sbjct: 1512 DQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREEL--ERQNRA--L 1567
Query: 998 RQEFEDRLAASEE--------ETRQAKAELATLQARQQL-ELEEVHRRVKTALARKEEAV 1048
R E E L++ ++ E AE A R Q+ ELE+ + A R E V
Sbjct: 1568 RAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTV 1627
Query: 1049 SSLRTQHEAAVKRADHLEELLEQHRR 1074
+L+TQHE ++ D E E+ RR
Sbjct: 1628 QALKTQHERDLQGRD---EAGEERRR 1650
Score = 100 bits (248), Expect = 1e-20
Identities = 192/818 (23%), Positives = 333/818 (40%), Gaps = 122/818 (14%)
Query: 298 QAKREEQRQRSGEGTLLDLHQQKEAARR-KAREEKARQARRAAIQELQQKRALRAQKAST 356
+A +E RQR G+ L +L +Q E ARR K EK R A A + EL RA + +
Sbjct: 1249 EAAVQELRQRHGQA-LGELAEQLEQARRGKGAWEKTRLALEAEVSEL---RAELSSLQTA 1304
Query: 357 AERGPPENPR-ETRVPGMRQPAQELSPTPGGTAHQALKAN----NTGGGLPAAGPGDRCL 411
+ G R E ++ ++ A + A + +A N G L A L
Sbjct: 1305 RQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRL 1364
Query: 412 PTSDSSPEPQ--QPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEK 469
SS E Q E ++ A+ A G + M A++ G E+L
Sbjct: 1365 SKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM-----EAEAAGLREQL--------- 1410
Query: 470 EPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSI 529
E + R R + A A S E+ G L A E +EA Q +
Sbjct: 1411 EEEAAARERAGRELQTAQAQ----LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRL 1466
Query: 530 MSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQR 589
+ +++ + + QQE ++L + R + EKKQ +
Sbjct: 1467 AEKTETVDRLERGRRRLQQE-----LDDATMDLEQQ------RQLVSTLEKKQRKF--DQ 1513
Query: 590 ALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVV 649
LA+++ R V+E E+A + R+RE ++ R L ++ E ++ L + A+
Sbjct: 1514 LLAEEKAAVLRAVEERERAEAEG--REREARALSLTRAL---EEEQEAREELERQNRALR 1568
Query: 650 AELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLE 709
AEL + + + ++ HELE R ++E+ V LE
Sbjct: 1569 AEL---EALLSSKDDVGKSVHELE---------------RACRVAEQAANDLRAQVTELE 1610
Query: 710 PEI---QKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELRE-QLEREKEALGQ 765
E+ + R + V+ LK+ HE +L DE +R + A++LR+ ++ER++E +
Sbjct: 1611 DELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQR 1670
Query: 766 QERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEES 825
AR++ + LE+ L+ Q + + +E +Q + +A+++EL +++EE
Sbjct: 1671 TLAVAARKKLEGELEE----LKAQM----ASAGQGKEEAVKQLRKMQAQMKELWREVEE- 1721
Query: 826 SSALTRALRAE-FEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 884
TR R E F + RE ++R +E L+ Q EL + R R++ E
Sbjct: 1722 ----TRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAA----SDRARRQAQ---QDRDE 1770
Query: 885 LREEIRKGRDKEIELVIHRLEADMALAKEESEKAAE-SRIKRLRDKYE----------AE 933
+ +E+ G + ++ + + + L + E E E S + L D+Y E
Sbjct: 1771 MADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTE 1830
Query: 934 LS-------ELEQSERKLQERCSELKGQLGEAE-GENLRLQGLVRQKERALEDAQAVNEQ 985
LS + E ++L+ + EL+G+LGE + G R + + E L A+ EQ
Sbjct: 1831 LSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQ 1890
Query: 986 LSSER-----------SNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQL-ELEEV 1033
+ ER L +V+ Q E+R A + + K L Q ++QL E EE
Sbjct: 1891 ETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEE 1950
Query: 1034 HRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1071
R + R + + + E+ + L L +
Sbjct: 1951 ASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1988
Score = 77.8 bits (190), Expect = 5e-14
Identities = 183/816 (22%), Positives = 323/816 (39%), Gaps = 175/816 (21%)
Query: 231 KNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGA 290
+NVS A + A + T + E +A+ + + +A + + R
Sbjct: 1348 ENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLR 1407
Query: 291 ARLEHLLQAKREEQRQ-RSGEGTLLDLH--QQKEAARRKAREEKARQARRAAIQELQQKR 347
+LE A+ R+ ++ + L + Q++EA +A EE R+A R A + L Q+
Sbjct: 1408 EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREA-EALTQRL 1466
Query: 348 ALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPG 407
A + + ER G R+ QEL Q
Sbjct: 1467 AEKTETVDRLER------------GRRRLQQELDDATMDLEQQRQLV------------- 1501
Query: 408 DRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLL 467
S+ E +Q D+ +LA++ A + R A+ R L + L
Sbjct: 1502 --------STLEKKQRKFDQ---LLAEEKAAVLRAVEERERAEAEGREREARALSLTRAL 1550
Query: 468 EKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQ 527
E+E + +R A E +A + D++ K E ++E
Sbjct: 1551 EEEQEAREELERQNRALRA----ELEALLSSKDDVGK------SVHELERACRVAEQAAN 1600
Query: 528 SIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLL 587
+ + + E+E D+L + ++ + + +V LK + E Q
Sbjct: 1601 DLRAQVTELE----DELTAAEDAKL------------RLEVTVQALKTQHERDLQGR--- 1641
Query: 588 QRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEA 647
A ++R A+++++ E ++R E + T+ + +K L + E
Sbjct: 1642 DEAGEERRRQLAKQLRDAE------VERDEERKQRTL---------AVAARKKLEGELEE 1686
Query: 648 VVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRG 707
+ A++ Q E V Q + ++KEL E+ R +
Sbjct: 1687 LKAQMASAGQGKEEAVKQLRKMQ----AQMKELWREVEETRTSR---------------- 1726
Query: 708 LEPEIQKLIARHKQEVRRLKSLHEAELLQSDER--ASQRCLRQAEELREQLERE------ 759
+++ +++++ +RLK L EAE+L+ E AS R RQA++ R+++ E
Sbjct: 1727 -----EEIFSQNRESEKRLKGL-EAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNL 1780
Query: 760 -KEALGQQER--ERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQR---A 813
K A+ +++R E + ++ LE+EQ + R Y ++ + E L + + +R A
Sbjct: 1781 SKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDR-YRKLLLQVESLTTELSAERSFSA 1839
Query: 814 ELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRK 873
+ E RQQLE L L E R RH+M + L+ +L QA E
Sbjct: 1840 KAESGRQQLERQIQELRGRLGEEDAGAR----ARHKMTIAALESKL---AQAEE------ 1886
Query: 874 EEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAE 933
EQE RE I G K + RL+ ++ L EE + A+ +LRD+ E
Sbjct: 1887 ------QLEQETRERILSG--KLVRRAEKRLK-EVVLQVEEERRVAD----QLRDQLE-- 1931
Query: 934 LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALED----AQAVNEQLSSE 989
K R +LK QL EAE E R Q R+ +R LED A+++N ++++
Sbjct: 1932 ---------KGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTL 1982
Query: 990 RSNL--------AQVIRQEFE-DRLAASEEETRQAK 1016
R+ L + +RQ F + AS+EE +A+
Sbjct: 1983 RNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 2018
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 117 bits (292), Expect = 8e-26
Identities = 184/816 (22%), Positives = 340/816 (41%), Gaps = 87/816 (10%)
Query: 254 KEVTEEEA---ERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGE 310
K+ EEE E I + Q T Q+++ A LE Q + ++ + E
Sbjct: 1180 KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1239
Query: 311 GTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERGPPENP---RE 367
+L + + +RK + + ++ A + E + R A+KAS + E
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELH-AKVSEGDRLRVELAEKASKLQNELDNVSTLLEE 1298
Query: 368 TRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDR 427
G++ S Q L T L + R L +S + QQ E+
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSR-IRQLEEEKNSLQEQQEEEEE 1357
Query: 428 TQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAW 487
+ L + ++ + G +E L + L K+ + L
Sbjct: 1358 ARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEAL------------- 1404
Query: 488 ASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQ 547
S+ + +L D LEK + + +D T+ + + Q + S L++ +K DQL ++
Sbjct: 1405 -SQRLEEKALAYDKLEK--TKNRLQQELDDLTVDLDHQRQ-VASNLEKKQKKF-DQLLAE 1459
Query: 548 QEG----WVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRA----------LAQ 593
++ + E E E T + L +EE +A +R L
Sbjct: 1460 EKSISARYAEERDRAEAE-AREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMS 1518
Query: 594 QRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKV-LSEKCEAVVAEL 652
+D + V E EK+ R L++Q E ++ L Q ED K+ L +A+ A+
Sbjct: 1519 SKDDVGKNVHELEKS-KRALEQQVEEMRTQLEE-LEDELQATEDAKLRLEVNMQAMKAQF 1576
Query: 653 KQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEI 712
+++ Q E Q + + L IK+++EL + E R+++ ++ +KK E+ ++ LE +I
Sbjct: 1577 ERDLQTRDE---QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQI 1633
Query: 713 QKLIARHKQEVRRLKSL------HEAELLQSDERASQ-RCLRQAEELREQLER-EKEALG 764
+ + +++L+ L ++ EL + RAS+ Q++E ++L+ E E L
Sbjct: 1634 EAANKARDEVIKQLRKLQAQMKDYQREL--EEARASRDEIFAQSKESEKKLKSLEAEILQ 1691
Query: 765 QQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEE 824
QE + +R ++H EQE+ L + + A + L + R A + +L ++LEE
Sbjct: 1692 LQEELASSERARRHAEQERDELADE----ITNSASGKSALLDEKRRLEARIAQLEEELEE 1747
Query: 825 SSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 884
S + ++ R+ ++++TL +L ER A + +++ N+E +
Sbjct: 1748 EQSNMELL---------NDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK 1798
Query: 885 LR-EEIRKGRDKEIELVIHRLEADMALAKEESEKAAESR------IKRLRDKYEAELSEL 937
+ +E+ + + I LEA + +E+ E+ A+ R ++R K + ++
Sbjct: 1799 AKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV 1858
Query: 938 EQSER----------KLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS 987
E R K R +LK QL EAE E R R+ +R L+DA NE LS
Sbjct: 1859 EDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLS 1918
Query: 988 SERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQ 1023
E S L +R+ ++S RQ E A+L+
Sbjct: 1919 REVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLE 1954
Score = 100 bits (250), Expect = 6e-21
Identities = 197/879 (22%), Positives = 365/879 (41%), Gaps = 165/879 (18%)
Query: 292 RLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRA 351
+++ LLQ R+E+ ++ + LL + +++ E + + R Q L++K L
Sbjct: 840 KVKPLLQVTRQEEELQAKDEELLKVKEKQTKV-----EGELEEMERKHQQLLEEKNILAE 894
Query: 352 QKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCL 411
Q + E R+ +Q +E+ + + N
Sbjct: 895 QLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQI-------------- 940
Query: 412 PTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q +D + + ++ A L++ + AK + EE+L LLE +
Sbjct: 941 -LQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVT-AEAKIKKMEEEIL----LLEDQN 994
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ + R A + SS A+ EK L+ E E +L+
Sbjct: 995 SKFIKEKKLMEDRIA------ECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEK 1048
Query: 532 FLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRAL 591
E+EK+ + +LD + + +E+ + LKL++ +K++ LQ AL
Sbjct: 1049 TRQELEKAKR-KLDGETTDLQDQI--------AELQAQIDELKLQLAKKEEE---LQGAL 1096
Query: 592 AQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAV--- 648
A+ D T K + R+LQ Q + + A ++ + K+ LSE+ EA+
Sbjct: 1097 ARGDDETLH--KNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTE 1154
Query: 649 ---------------------VAELKQE-DQRCTERVAQAQAQHELEIKKLKELMSATEK 686
VAELK+ ++ AQ Q + L+EL E+
Sbjct: 1155 LEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQ 1214
Query: 687 ARREKWISEKTKKIKEVTVRGLEPEIQ-----KLIARHKQEV--RRLKSLHE-------- 731
A+R K EK K+ E + L E++ K + HK++ +++ LH
Sbjct: 1215 AKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRL 1274
Query: 732 ------------------AELLQSDERASQRCLRQAEELREQLEREKEALGQQERERAR- 772
+ LL+ E+ + + A L QL+ +E L ++ R++
Sbjct: 1275 RVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNL 1334
Query: 773 -QRFQQHLEQEQWALQQQRQR--------------LYSEVAEERERLGQQAARQRAELEE 817
R +Q LE+E+ +LQ+Q++ L S++A+ ++++ + LEE
Sbjct: 1335 SSRIRQ-LEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIES-LEE 1392
Query: 818 LRQQLEESSSALTRALRAE---FEKGREEQERRHQMELNTLKQQLELERQ-AWEAGRTRK 873
+++L + + AL++ L + ++K E+ + R Q EL+ L L+ +RQ A + +K
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDK-LEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQK 1451
Query: 874 EEAWLLNREQELREEIRKGRDK-EIELVIHRLEA-DMALAKEESEKAAES---RIKRLRD 928
+ LL E+ + + RD+ E E +A +A A EE+ +A E + K+LR
Sbjct: 1452 KFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRA 1511
Query: 929 KYEAELS----------ELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALED 978
E +S ELE+S+R L+++ E++ QL E E E +A ED
Sbjct: 1512 DMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL-----------QATED 1560
Query: 979 AQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVK 1038
A+ E N+ Q ++ +FE L +E+ + K L + ELE+ ++
Sbjct: 1561 AKLRLEV------NM-QAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRA 1613
Query: 1039 TALARKEEA---VSSLRTQHEAAVKRADHLEELLEQHRR 1074
A+A K++ + L Q EAA K D E+++Q R+
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARD---EVIKQLRK 1649
Score = 100 bits (248), Expect = 1e-20
Identities = 169/716 (23%), Positives = 290/716 (40%), Gaps = 184/716 (25%)
Query: 535 EMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRAL--- 591
E EK+ +++ + Q+ E EL + T+ + +L + ++Q + L++AL
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTK-REQEVAELKKALEEE 1186
Query: 592 -----AQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH----------LAFIDQLIE 636
AQ +D+ R E+ LS QL+ Q + ++A ++++ LA ++++
Sbjct: 1187 TKNHEAQIQDMRQRHATALEE-LSEQLE-QAKRFKANLEKNKQGLETDNKELACEVKVLQ 1244
Query: 637 DKKVLSE----KCEAVVAELK---QEDQRCTERVAQAQAQHELEIKKLKELMSATEK--- 686
K SE K +A V EL E R +A+ ++ + E+ + L+ EK
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGI 1304
Query: 687 ------ARREKWISEKTKKIKEVT---------VRGLEPEIQKLIARHKQEVRRLKSLHE 731
A E + + + ++E T +R LE E L + ++E K+L +
Sbjct: 1305 KFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK 1364
Query: 732 AEL-------------------LQSDERASQRCLRQAEELREQLEREKEALGQQERERAR 772
L ++S E A ++ L+ AE L ++LE ++AL + E+ +
Sbjct: 1365 QVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE--EKALAYDKLEKTK 1422
Query: 773 QRFQQHLEQEQWALQQQRQ--------------------RLYSEVAEERERLGQQAARQR 812
R QQ L+ L QRQ + + AEER+R +A +
Sbjct: 1423 NRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKE 1482
Query: 813 AELEELRQQLEESSSAL------TRALRA-----------------EFEKGREEQERRHQ 849
+ L + LEE+ A + LRA E EK + E++ +
Sbjct: 1483 TKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVE 1542
Query: 850 MELNTLKQQLELERQAWEAGRTRKE----------EAWLLNREQELREE----IRKGRDK 895
E+ T ++LE E QA E + R E E L R+++ E+ I++ R+
Sbjct: 1543 -EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVREL 1601
Query: 896 EIELVIHRLEADMALAK---------------EESEKAAESRIKRLRD------KYEAEL 934
E EL R + +A+A E + KA + IK+LR Y+ EL
Sbjct: 1602 EAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQREL 1661
Query: 935 SELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLA 994
E S ++ + E + +L E E L+LQ + ERA A+ ++L+ E +N A
Sbjct: 1662 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721
Query: 995 QVI------RQEFEDRLAASEEETRQAKAEL---------ATLQ---------------- 1023
++ E R+A EEE + ++ + TLQ
Sbjct: 1722 SGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ 1781
Query: 1024 ----ARQQLELEEVHRRVKTALARKEEAV-SSLRTQHEAAVKRADHLEELLEQHRR 1074
ARQQLE + ++ +K L E AV S + A + LEE LEQ +
Sbjct: 1782 KSDNARQQLERQ--NKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAK 1835
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 114 bits (285), Expect = 5e-25
Identities = 134/623 (21%), Positives = 290/623 (46%), Gaps = 63/623 (10%)
Query: 438 GDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSL 497
G+ ++++ S K G LE+ L + +K+ D T R S E +++
Sbjct: 158 GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDAL---SLELYRNTI 214
Query: 498 TADNL-EKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAG 556
T + L EK KL E L+ K + ++ + K + +L Q+ EA
Sbjct: 215 TDEELKEKNAKLQ------EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD 268
Query: 557 PGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTAR---RVKETEKALSRQL 613
LG E+ + +L+ +VEE + L R QQ + R +++E E+ + Q
Sbjct: 269 ----HLGKELQSVSAKLQAQVEENE----LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE 320
Query: 614 QRQREHYEATIQRH--LAFIDQLIEDKKVLSEKCEAVVAE----LKQEDQRCTERVAQAQ 667
++ RE E ++ + ++++ +K+ + E ++ E ++++++ E+ + +
Sbjct: 321 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 380
Query: 668 AQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLK 727
Q E+ +K +++ EK ++ I E+ +K +E E +I++ R +QE + +
Sbjct: 381 RQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE------EEKIREQEKRQEQEAKMWR 434
Query: 728 SLHEAELLQSDERASQ---RCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQW 784
E ++ + +E+ + + RQ E++ EQ + +E Q++ E RQ + H ++E W
Sbjct: 435 Q--EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIW 492
Query: 785 ALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQ 844
+++ ++ ++ E++ +Q + R + E++R+Q EE +R + E REE+
Sbjct: 493 RQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQ-EEKMWRQEEKIREQEEMWREEE 551
Query: 845 ERRHQMELNTLKQQLELERQAW-EAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHR 903
+ Q ++ +++ E E + W + + R++E + +E+++RE+ K +++E
Sbjct: 552 KMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQE------- 604
Query: 904 LEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENL 963
+ +EE + E +I+ + E ++ E E+ R+ +E E + ++GE E
Sbjct: 605 ---EKMWKQEEKIREQEEKIQ----EQEEKIREQEEKIREQEEMTQEQEEKMGEQE---- 653
Query: 964 RLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQ 1023
+ + Q+E+ E + + Q R ++ QE + R +EE Q + E Q
Sbjct: 654 --EKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIR---EQEEMMQEQEEKMWEQ 708
Query: 1024 ARQQLELEEVHRRVKTALARKEE 1046
+ E EE + + + R+EE
Sbjct: 709 EEKMCEQEEKMQEQEEKMRRQEE 731
Score = 99.8 bits (247), Expect = 1e-20
Identities = 154/725 (21%), Positives = 321/725 (44%), Gaps = 84/725 (11%)
Query: 362 PENPRETRVPGMRQPAQELS-------PTPGGTAHQALKANNTGGGLPAAGPGDRCLPTS 414
P +ETR + + ++L+ P+ G A K G P C
Sbjct: 49 PMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGC---- 104
Query: 415 DSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVL 474
SPE +Q + Q+ L ++ + + + + L H ++ LE E L
Sbjct: 105 -HSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDL 163
Query: 475 PRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLD 534
R H ++A E + A S A +K + E ++ LS ++ ++ D
Sbjct: 164 IS-RLHDSWKFA--GELEQALSAVATQKKKADRY--IEELTKERDALSLELYRNTIT--D 216
Query: 535 EMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQ 594
E K +L + + E SE+ +V LK ++E K +LL Q+ L +
Sbjct: 217 EELKEKNAKLQEKLQLVESEK--------SEIQLNVKELKRKLERAK--LLLPQQQLQAE 266
Query: 595 RDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSE-KCEAVVAELK 653
D + ++ ++S +LQ Q E E + ++Q E+K E K + +++
Sbjct: 267 ADHLGKELQ----SVSAKLQAQVEENELWNR-----LNQQQEEKMWRQEEKIQEWEEKIQ 317
Query: 654 QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARR-EKWISEKTKKIKEVTVRGLEPEI 712
+++++ E+ + + Q E ++ + + EK RR E+ + EK +K++ E E
Sbjct: 318 EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE- 376
Query: 713 QKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERAR 772
+K+ + + + + + E E ++ Q +R+ EE R++ E+ +E +QE+E
Sbjct: 377 EKMRRQEEMMWEKEEKIRELE----EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 432
Query: 773 QRFQQHLEQEQWALQQQRQRLY--SEVAEERERLGQQAARQRAELEELRQQLEESSSALT 830
R ++ + +++ +++Q ++++ E E+E++ ++ RQ E EE+ +Q E+
Sbjct: 433 WRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQ--EQEEMWRQEEKIHEQ-- 488
Query: 831 RALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIR 890
+ + EK E++E+ + E +Q+ ++ Q E R ++E+ W +E+++RE+
Sbjct: 489 EEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQE-EKIREQEEKMW--RQEEKIREQEE 545
Query: 891 KGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSE 950
R++E ++ + +EE + E ++ R +K + ++ + E K++E+ E
Sbjct: 546 MWREEE------KMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQ--E 597
Query: 951 LKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEE 1010
K Q E + + +Q+E+ E + + EQ R E E+++ EE
Sbjct: 598 EKRQEQEEK--------MWKQEEKIREQEEKIQEQEEKIR---------EQEEKIREQEE 640
Query: 1011 ETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAV----SSLRTQHEAAVKRADHLE 1066
T Q + E Q + E EE + + + R+EE + +R Q E ++ + ++
Sbjct: 641 MT-QEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQ 699
Query: 1067 ELLEQ 1071
E E+
Sbjct: 700 EQEEK 704
Score = 95.1 bits (235), Expect = 3e-19
Identities = 123/558 (22%), Positives = 252/558 (45%), Gaps = 76/558 (13%)
Query: 561 ELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQ----QRDLTARR------VKETEKALS 610
EL ++V T + L + E + A+ Q A+ Q RDL +R E E+ALS
Sbjct: 124 ELEAQVHT-IRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALS 182
Query: 611 -------------RQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAV--------- 648
+L ++R+ + R+ ++L E L EK + V
Sbjct: 183 AVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQL 242
Query: 649 -VAELKQEDQRCTERVAQAQAQHELEI--KKLKELMSATEKARREKWISEKTKKIKEVTV 705
V ELK++ +R + Q Q Q E + K+L+ + + + E + + + +E +
Sbjct: 243 NVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKM 302
Query: 706 RGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQ 765
E +IQ+ + +++ +++ + E ++ E +R E E++ R++E + +
Sbjct: 303 WRQEEKIQEWEEKIQEQEEKIRE--QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360
Query: 766 QERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEES 825
+E + RQ E+ W ++++ R E+ E+E ++ + E E++R+Q E+
Sbjct: 361 KEEKMRRQ------EEMMWE-KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK- 412
Query: 826 SSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQEL 885
R E EK RE QE+R + E +Q+ ++ Q E R ++++ W R++E
Sbjct: 413 --------RQEEEKIRE-QEKRQEQEAKMWRQEEKIREQE-EKIREQEKKMW---RQEEK 459
Query: 886 REEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKL- 944
E K R++E + + + ++E + + I R ++K + ++ + E K+
Sbjct: 460 IHEQEKIREEE------KRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVW 513
Query: 945 --QERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFE 1002
+E+ E + ++ E E + R + +R++E + + ++EQ + RQE E
Sbjct: 514 RQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQ----EKIWEEEKRQEQE 569
Query: 1003 DRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRA 1062
D++ EE+ R+ + E Q + E EE + + + ++EE +R Q E ++
Sbjct: 570 DKMWRQEEKIRE-QEEKVWRQEEKIREQEEKRQEQEEKMWKQEE---KIREQEEKIQEQE 625
Query: 1063 DHLEELLEQHRRPTPSTK 1080
+ + E E+ R T+
Sbjct: 626 EKIREQEEKIREQEEMTQ 643
Score = 89.4 bits (220), Expect = 2e-17
Identities = 95/419 (22%), Positives = 205/419 (48%), Gaps = 49/419 (11%)
Query: 571 MRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAF 630
MR + E+ +K+ + Q + +++ RR +E +++RQ E ++
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL 396
Query: 631 IDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKA--R 688
+++ E +K+ ++ + E +E ++ E+ A+ Q E +I++ +E + EK R
Sbjct: 397 EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE-KIREQEEKIREQEKKMWR 455
Query: 689 REKWISEKTKKIKEVTVRGLEPEIQKLIAR-HKQEV--RRLKSLHEAELLQSDERASQRC 745
+E+ I E+ +KI+E R + E+ + + H+QE R+ + +HE E + + ++
Sbjct: 456 QEEKIHEQ-EKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQE--EKIRKQEEKV 512
Query: 746 LRQAEELREQLE----------REKEALGQQERERARQRFQQHLEQEQWALQQQRQ---- 791
RQ E++REQ E R++E + +QE E R+ + H +++ W +++++
Sbjct: 513 WRQEEKIREQEEKIREQEEKMWRQEEKIREQE-EMWREEEKMHEQEKIWEEEKRQEQEDK 571
Query: 792 --RLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQ 849
R ++ E+ E++ +Q + R E EE RQ+ EE +R + EK +E++E+ +
Sbjct: 572 MWRQEEKIREQEEKVWRQEEKIR-EQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIRE 630
Query: 850 MELNTLKQQLELERQAWEAG-----------RTRKEEAWLLNREQELREEIRKGRDKEIE 898
E +Q+ + Q + G + +++E + +E+++RE+ +K R++E +
Sbjct: 631 QEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEK 690
Query: 899 L-----VIHRLEADM------ALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQE 946
+ ++ E M +EE + E +++R +K + L Q E K+QE
Sbjct: 691 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 80.9 bits (198), Expect = 6e-15
Identities = 76/385 (19%), Positives = 190/385 (49%), Gaps = 38/385 (9%)
Query: 579 EKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDK 638
EK++ + L+ + +Q + + K E+ R+ Q +R+ EA + R +++
Sbjct: 388 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE-QEKRQEQEAKMWR---------QEE 437
Query: 639 KVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREK---WISE 695
K+ + E + E +++ R E++ + + E E ++ +E M E+ E+ W +
Sbjct: 438 KIREQ--EEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495
Query: 696 KTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQ 755
+ +E +R E ++ + + +++ +++ E Q ++ +R+ EE+
Sbjct: 496 EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEK------IREQEEM--- 546
Query: 756 LEREKEALGQQER---ERARQRFQQHLEQEQWALQQQRQRLY---SEVAEERERLGQQAA 809
RE+E + +QE+ E RQ + + +++ +++Q ++++ ++ E+ E+ +Q
Sbjct: 547 -WREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEE 605
Query: 810 RQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAG 869
+ + E++R+Q EE +R + EK RE++E + E +Q+ E+ +
Sbjct: 606 KMWKQEEKIREQ-EEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQE---EKMCEQEE 661
Query: 870 RTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDK 929
+ +++E + +E+++RE+ +K R++E ++ R + +M +EE E ++ +K
Sbjct: 662 KMQEQEETMWRQEEKIREQEKKIREQEEKI---REQEEMMQEQEEKMWEQEEKMCEQEEK 718
Query: 930 YEAELSELEQSERKLQERCSELKGQ 954
+ + ++ + E K+ E+ L+ Q
Sbjct: 719 MQEQEEKMRRQEEKMWEQEVRLRQQ 743
Score = 75.5 bits (184), Expect = 3e-13
Identities = 73/362 (20%), Positives = 179/362 (49%), Gaps = 28/362 (7%)
Query: 523 EAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQ 582
E K++ + + E EK + + Q+E + E E E + R + ++ E+++
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ-----EKRQEQEAKMWRQEEKIREQEE 444
Query: 583 AMLLLQRALAQQRDLT--ARRVKETEKALSRQ---LQRQREHYEATIQRHLAFIDQLIED 637
+ ++ + +Q + +++E EK ++ Q ++ H + I R + + E
Sbjct: 445 KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEK 504
Query: 638 KKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREK--WISE 695
+ EK ++++++++ E+ + Q E +I++ +E+ EK ++ W E
Sbjct: 505 IRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEE-KIREQEEMWREEEKMHEQEKIWEEE 563
Query: 696 KTKKIKEVTVRGLEP--EIQKLIARHKQEVRRLKSLH---EAELLQSDERA---SQRCLR 747
K ++ ++ R E E ++ + R ++++R + E ++ + +E+ ++
Sbjct: 564 KRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQE 623
Query: 748 QAEELREQLE--REKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSE---VAEERE 802
Q E++REQ E RE+E + Q++ E+ ++ ++ EQE+ +Q+Q + ++ + + E+ +
Sbjct: 624 QEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE-KMQEQEETMWRQEEKIREQEK 682
Query: 803 RLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELE 862
++ +Q + R E EE+ Q+ EE + + EK +E++E+ + E +Q++ L
Sbjct: 683 KIREQEEKIR-EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLR 741
Query: 863 RQ 864
+Q
Sbjct: 742 QQ 743
Score = 55.8 bits (133), Expect = 2e-07
Identities = 62/318 (19%), Positives = 155/318 (48%), Gaps = 36/318 (11%)
Query: 533 LDEMEKSGQDQL-DSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRAL 591
+ E EK +++ Q+E W E E + R K ++ E+++ + + +
Sbjct: 460 IHEQEKIREEEKRQEQEEMWRQEEKIHEQE-------EIWRQKEKMHEQEEKIRKQEEKV 512
Query: 592 AQQRDLTAR---RVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAV 648
+Q + +++E E+ + RQ ++ RE E + +++ E +K+ E+
Sbjct: 513 WRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREE-----EKMHEQEKIWEEE---- 563
Query: 649 VAELKQEDQ--RCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVR 706
+QED+ R E++ + + + + +K++E ++ + W E+ + +E ++
Sbjct: 564 -KRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQ 622
Query: 707 GLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQ 766
E +I++ ++++R + + + + + E+ + C E E+++ ++E + +Q
Sbjct: 623 EQEEKIRE----QEEKIREQEEMTQEQEEKMGEQEEKMC-----EQEEKMQEQEETMWRQ 673
Query: 767 ERERARQRFQQHLEQEQWALQQQR--QRLYSEVAEERERLGQQAARQRAELEELRQQLEE 824
E E+ R++ ++ EQE+ +Q+ Q ++ E+ E++ +Q + + + E++R+Q E+
Sbjct: 674 E-EKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 732
Query: 825 SSSALTRALRAEFEKGRE 842
R LR + EK +E
Sbjct: 733 MWEQEVR-LRQQEEKMQE 749
Score = 53.5 bits (127), Expect = 1e-06
Identities = 89/380 (23%), Positives = 153/380 (40%), Gaps = 71/380 (18%)
Query: 713 QKLIARHKQEVRRL--KSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERER 770
QK +H++ +RR +H +L + Q L ++ +QLE E L R
Sbjct: 111 QKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDL--ISRLH 168
Query: 771 ARQRFQQHLEQEQWALQQQRQ---RLYSEVAEERERLGQQAARQRAELEELRQQLEESSS 827
+F LEQ A+ Q++ R E+ +ER+ L + R EEL+ E ++
Sbjct: 169 DSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELK----EKNA 224
Query: 828 ALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELRE 887
L L+ E ++ Q+ + LK++LE A LL +Q+L+
Sbjct: 225 KLQEKLQLV-----ESEKSEIQLNVKELKRKLE--------------RAKLLLPQQQLQA 265
Query: 888 EIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQER 947
E KE++ V +L+A + EE+E RL + E ++ E+ ++ +E+
Sbjct: 266 EADH-LGKELQSVSAKLQAQV----EENELW-----NRLNQQQEEKMWRQEEKIQEWEEK 315
Query: 948 CSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAA 1007
E Q+E+ E + + EQ E+ + + E E+++
Sbjct: 316 IQE--------------------QEEKIREQEEKIREQ--EEKMRRQEEMMWEKEEKMRR 353
Query: 1008 SEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQ-------HEAAVK 1060
+EE K E Q E EE RR + + KEE + L + E K
Sbjct: 354 -QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 412
Query: 1061 RADHLEELLEQHRRPTPSTK 1080
R + E++ EQ +R K
Sbjct: 413 RQEE-EKIREQEKRQEQEAK 431
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 111 bits (277), Expect = 4e-24
Identities = 148/578 (25%), Positives = 270/578 (46%), Gaps = 96/578 (16%)
Query: 559 PLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQRE 618
PL ++ + L+ E+ + A+ + A Q+ + T + + + L+ QLQ +++
Sbjct: 887 PLLRSAQAEEELAALRAELRGLRGALAAAE-AKRQELEETHVSITQEKNDLALQLQAEQD 945
Query: 619 HYEATIQR-HLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE--LEIK 675
+ +R HL LI+ K L K + + L+ E++ + A+ + + E+K
Sbjct: 946 NLADAEERCHL-----LIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELK 1000
Query: 676 K-LKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAEL 734
K + +L KA +EK +E K+K +T + + +AR +E + L+ H+ L
Sbjct: 1001 KDIDDLKLTLAKAEKEKQATEN--KVKNLTEE--MAALDESVARLTKEKKALQEAHQQAL 1056
Query: 735 --LQSDE-------RASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLE----- 780
LQ++E +A R +Q E+L LE+EK+ + + ERA+++ + L+
Sbjct: 1057 GDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKL--RMDTERAKRKLEGDLKLTQES 1114
Query: 781 -----QEQWALQQQRQRLYSEVA------EERERLGQQAARQRAELEELRQQLEESSSAL 829
Q++ L+++ ++ SE++ E+ + LG Q ++ EL+ ++LEE A
Sbjct: 1115 VADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEA- 1173
Query: 830 TRALRAEFEK------------------------GREEQERRHQMELNTLKQQLE---LE 862
RA RA EK G+ E R+ + EL L+++LE L
Sbjct: 1174 ERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALR 1233
Query: 863 RQAWEAGRTRK--EEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAE 920
+A A RK E A L + + + +R+ +KE + R+E D A E+ A+
Sbjct: 1234 HEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSEL--RMEVDDLAANVETLTRAK 1291
Query: 921 SRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQ 980
+ ++L YE +LSE + + EL+ QL +A + RLQ + R LE+ +
Sbjct: 1292 ASAEKLCRTYEDQLSE-------AKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKE 1344
Query: 981 AVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELA-TLQA--------RQQLELE 1031
+ QLS ++ AQ + + L EE +AK+ LA +QA R+Q E E
Sbjct: 1345 CLISQLSRGKALAAQSL-----EELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEE 1399
Query: 1032 -EVHRRVKTALARKEEAVSSLRTQHEA-AVKRADHLEE 1067
E ++ L++ V+ R+++EA A++R + LEE
Sbjct: 1400 AEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEE 1437
Score = 107 bits (268), Expect = 5e-23
Identities = 168/666 (25%), Positives = 285/666 (42%), Gaps = 110/666 (16%)
Query: 491 EDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEG 550
ED+ + L D ++ A E + T L M+ LDE + + QE
Sbjct: 993 EDECTELKKD-IDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEA 1051
Query: 551 WVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLT-----ARRVKET 605
+ G L+ + +++ + KL +E++ + L+ +L Q++ L A+R E
Sbjct: 1052 H--QQALGDLQAEEDRVSALTKAKLRLEQQVED---LECSLEQEKKLRMDTERAKRKLEG 1106
Query: 606 EKALSRQ----LQRQREHYEATIQRHLAFIDQL---IEDKKVLSEKCEAVVAELKQ---- 654
+ L+++ + ++ E +++ + + QL +ED+++L + + + EL+
Sbjct: 1107 DLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEE 1166
Query: 655 -EDQRCTERVAQAQAQHELE--IKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPE 711
E++ ER A+A+ + + ++L+EL E+A + + +E + L E
Sbjct: 1167 LEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRE 1226
Query: 712 IQKLIARHKQEV---RRLKSLHEAEL---LQSDERASQRCLRQAEELR----------EQ 755
+++ RH+ V RR ++ AEL + S +R Q+ ++ ELR E
Sbjct: 1227 LEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVET 1286
Query: 756 LEREKEALGQQERERARQRFQQHLEQEQWALQ-----QQRQRLYSE------VAEERERL 804
L R K + + R Q + ++ E+ Q QR RL +E + EE+E L
Sbjct: 1287 LTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECL 1346
Query: 805 GQQAARQRA----ELEELRQQLEESS---SALTRALRA-----EFEKGREEQERRHQMEL 852
Q +R +A LEELR+QLEE S SAL A++A + + + E+E Q EL
Sbjct: 1347 ISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAEL 1406
Query: 853 NTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRK----------------GRDKE 896
L + E W + K EA + R +EL E +K +
Sbjct: 1407 QRLLSKANAEVAQWRS----KYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSS 1462
Query: 897 IELVIHRLEA---DMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKG 953
+E RL+ D+ L E + AA + K+ R A LE+ R+ +E EL+
Sbjct: 1463 LEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERA----LEERRRQEEEMQRELEA 1518
Query: 954 QLGEAEGENLRLQGLVRQKERALEDAQAV---NEQLSSERSNLAQVIR------QEFEDR 1004
E+ G L L E ALE + + N+ L E S+L + QE E
Sbjct: 1519 AQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKT 1578
Query: 1005 LAASEEETRQAKAELA----------TLQARQQLELEEVHRRVKTALARKEEAVSSLRTQ 1054
A E E + +A L T R QLEL +V V LA K+E ++LR
Sbjct: 1579 KKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRN 1638
Query: 1055 HEAAVK 1060
H+ AV+
Sbjct: 1639 HQRAVE 1644
Score = 103 bits (256), Expect = 1e-21
Identities = 198/862 (22%), Positives = 341/862 (39%), Gaps = 130/862 (15%)
Query: 250 LPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAAR-LEHLLQAKREEQRQRS 308
L R E EEE E +R R +V+++ A AAR LE L + E +
Sbjct: 1160 LQARAEELEEELEA------------ERAARARVEKQRAEAARELEELSERLEEAGGASA 1207
Query: 309 GEGTLLDLHQQKEAARRKARE--EKARQARRAAIQELQQKRALRAQKAS-TAERGPPENP 365
G Q+E R++ E R+ AA++ ALR ++A AE G
Sbjct: 1208 G---------QREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGE---- 1254
Query: 366 RETRVPGMRQPAQELSPTPGGTAHQA--LKANNTGGGLPAAGPGDRCLPTSDSSPEPQQP 423
+V +++ Q+L + L AN A C D E +
Sbjct: 1255 ---QVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIK 1311
Query: 424 PED--------RTQDVLAQDAAGDNLEMMAP--------SRGSAKSRGPLEELLHTLQLL 467
E+ TQ Q +G+ ++ SRG A + LEEL L+
Sbjct: 1312 VEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEE 1371
Query: 468 EKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQ 527
K L R E+ + + L++ LS EA
Sbjct: 1372 SKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRL--LSKANAEVAQWRSKYEADAI 1429
Query: 528 SIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVE-EKKQAMLL 586
L+E +K +L +EG +E + +S+ + KL ++ E + L
Sbjct: 1430 QRTEELEEAKKKLALRLQEAEEG---------VEAANAKCSSLEKAKLRLQTESEDVTLE 1480
Query: 587 LQRALAQQRDLTARRVKETEKALS---RQLQRQREHYEATIQRHLAFIDQLIEDKKVLSE 643
L+RA + L ++ + E+AL RQ + + EA + +L + E
Sbjct: 1481 LERATSAAAALDKKQ-RHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEE 1539
Query: 644 KCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREK------------ 691
EA+ LK+E++ E ++ Q L K ++EL + EK
Sbjct: 1540 ALEALET-LKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEG 1598
Query: 692 -WISEKTKKIK-EVTVRGLEPEIQKLIARHKQEVRRLKSLHE--AELLQSDERASQRCLR 747
E+TK ++ ++ + ++ E+ + +A +E L+ H+ E LQ+ A R
Sbjct: 1599 ALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARN 1658
Query: 748 QAEELREQLEREKEALGQQ---------ERERARQRFQQHLEQEQWALQQQRQRLYSEVA 798
+A L++++E + L Q E + A + Q L++EQ A + + QRL +E+
Sbjct: 1659 EALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQ-AGRDEEQRLAAELH 1717
Query: 799 EERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQ 858
E+ + L ++A+ AELEELR LE+ + R E + E H L Q+
Sbjct: 1718 EQAQALERRASLLAAELEELRAALEQGERS-RRLAEQELLEATERLNLLHSQNTGLLNQK 1776
Query: 859 LELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKA 918
+LE + A L +E +E R+ +K + + L KE+ A
Sbjct: 1777 KKLE----------ADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSA 1826
Query: 919 AESRIKRLRD----KYEAELSELEQSE--------RKLQERCSELKGQLGEAEGENLRLQ 966
R+K+ + + +A L E EQ+ +KL+ + EL+ +L + ++
Sbjct: 1827 HLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEAL 1886
Query: 967 GLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAAS--------EEETRQAKAE 1018
VR+ ER +++ + Q +R NLA++ Q+ D+L + EE +QA
Sbjct: 1887 KGVRKHERRVKE---LAYQAEEDRKNLARM--QDLVDKLQSKVKSYKRQFEEAEQQANTN 1941
Query: 1019 LATLQARQQLELEEVHRRVKTA 1040
LA + + Q EL++ R A
Sbjct: 1942 LAKYR-KAQHELDDAEERADMA 1962
Score = 73.6 bits (179), Expect = 1e-12
Identities = 87/384 (22%), Positives = 164/384 (42%), Gaps = 33/384 (8%)
Query: 714 KLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQ 773
KL + K +R ++ E L+++ R + L AE R++LE ++ Q++ + A Q
Sbjct: 880 KLFFKMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQ 939
Query: 774 RFQQH-----LEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSA 828
+ E+ L + + +L +V E ERL + A+L R++LE+ +
Sbjct: 940 LQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERL-EDEEEVNADLAARRRKLEDECTE 998
Query: 829 LTRA---LRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQEL 885
L + L+ K +E++ N ++ L+ R KE+ L Q+
Sbjct: 999 LKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESV---ARLTKEKKALQEAHQQA 1055
Query: 886 REEIRKGRDKEIELVIHRLEADMAL----AKEESEKAAESRIKRLRDKYEAELS------ 935
+++ D+ L +L + + E EK +R + K E +L
Sbjct: 1056 LGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESV 1115
Query: 936 -----ELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSER 990
+ +Q E KL+++ SEL E E L + ++ + A+ + E+L +ER
Sbjct: 1116 ADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAER 1175
Query: 991 SNLAQVIRQEFE-----DRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKE 1045
+ A+V +Q E + L+ EE A A +++ EL + R ++ A R E
Sbjct: 1176 AARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHE 1235
Query: 1046 EAVSSL-RTQHEAAVKRADHLEEL 1068
V++L R Q E A + + ++ L
Sbjct: 1236 ATVAALRRKQAEGAAELGEQVDSL 1259
Score = 46.2 bits (108), Expect = 2e-04
Identities = 47/199 (23%), Positives = 89/199 (44%), Gaps = 38/199 (19%)
Query: 913 EESEKAAESRIKRLRDKY---EAELSELEQSERKLQERCSELKGQLGEAEGENL------ 963
EE A + ++ LR EA+ ELE++ + + ++L QL +AE +NL
Sbjct: 895 EEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQL-QAEQDNLADAEER 953
Query: 964 ---------RLQGLVRQKERALEDAQAVNEQLSSERSNLAQV---IRQEFED-------- 1003
+L+G V++ LED + VN L++ R L ++++ +D
Sbjct: 954 CHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKA 1013
Query: 1004 --RLAASEEETRQAKAELATLQ------ARQQLELEEVHRRVKTALARKEEAVSSLRTQH 1055
A+E + + E+A L +++ L+E H++ L +E+ VS+L
Sbjct: 1014 EKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAK 1073
Query: 1056 EAAVKRADHLEELLEQHRR 1074
++ + LE LEQ ++
Sbjct: 1074 LRLEQQVEDLECSLEQEKK 1092
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 108 bits (270), Expect = 3e-23
Identities = 187/763 (24%), Positives = 314/763 (41%), Gaps = 97/763 (12%)
Query: 307 RSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERGPPENPR 366
R+ E +L D + A ++K R A E ++K AL+ ++ +
Sbjct: 728 RAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLE-EEKSALQGRQRQAEQEATVAREE 786
Query: 367 ETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPED 426
+ R+ +R + A Q L+ G L A L E Q P
Sbjct: 787 QERLEELRLEQE--------VARQGLE-----GSLRVAEQAQEAL-------EQQLPTLR 826
Query: 427 RTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYA 486
+ L + A + ++ + ++R + + L+ +E + L + +
Sbjct: 827 HERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLV 886
Query: 487 WASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDS 546
A E S E+ +L E E + +L + + +++E GQ L +
Sbjct: 887 AAEREGRTLS------EEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLA 940
Query: 547 QQEGWVPEAGPGPLELGSEVSTSV----MRLKL-EVEEKKQAMLLLQRALAQQRDLTARR 601
++ AG + ++ S+ M KL + E + QA L QRA A + DL +R
Sbjct: 941 KETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRA-AHEEDL--QR 997
Query: 602 VKETEKALSRQLQRQREHYEATIQRHLA-FIDQLIEDKKVLSEKCEAVVAELKQEDQRCT 660
++ ++A R+L+ +R ++ +QR + +L +K+ LSE+ A+ E +
Sbjct: 998 LQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE 1057
Query: 661 ERVAQAQAQHELEIKKLKELMSATEKA--------RREKWISEKTKKIKEVTVRGLEPEI 712
QA + E E L E + T + R+K ++ ++ TV L E+
Sbjct: 1058 SEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSEL 1117
Query: 713 QKLIAR-------HKQEVRRLKSLHEAELLQSDERASQR--CLRQAEELREQLEREKEAL 763
+ L A+ H QEVRRL+ Q+ + QR CLR+AEELR QL ++A
Sbjct: 1118 RDLRAQREEAAAAHAQEVRRLQE-------QARDLGKQRDSCLREAEELRTQLRLLEDAR 1170
Query: 764 GQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLE 823
RE Q+ L + Q + QRQ E E R LG+ A E E LR+ E
Sbjct: 1171 DGLRRELLEA--QRKLRESQEGREVQRQ----EAGELRRSLGEGAK----EREALRRSNE 1220
Query: 824 ESSSALTRAL--RAEFEKGREEQERRHQM----------ELNTLKQQL-ELERQAWEAGR 870
E SA+ +A R + E++E++ + E L+ L E+ER EA R
Sbjct: 1221 ELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARR 1280
Query: 871 TRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKY 930
+E L R+ ++ + +E+ + RL KE + R + L+ +
Sbjct: 1281 ELQE----LRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEA 1336
Query: 931 EAEL--SELEQSERKLQERCSE-------LKGQLGEAEGENLRLQGLVRQKERALEDAQA 981
E+ EL+ ++RKLQE+ E L G L EA G + R E LE A+A
Sbjct: 1337 SLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARA 1396
Query: 982 VNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQA 1024
+L R + A+ Q E LA E + R A+A+L L++
Sbjct: 1397 EAAELGL-RLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRS 1438
Score = 106 bits (265), Expect = 1e-22
Identities = 140/531 (26%), Positives = 242/531 (45%), Gaps = 72/531 (13%)
Query: 558 GPLELGSEVSTSVMRLKL--EVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQR 615
G ++ + V RL+ E+ ++++ L +AQQ+ R+ +E +A +L+R
Sbjct: 579 GAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRR 638
Query: 616 QREHYE----------ATIQRHLAF----IDQLIEDKKVLSEKC----EAVVAELKQEDQ 657
QR+ E A ++R L ++QL + VL+++ EA+ Q D
Sbjct: 639 QRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDM 698
Query: 658 RCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIA 717
E+ A+A + E +++ +S T+ E + + K+ + + +A
Sbjct: 699 LQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSA---------LNESLA 749
Query: 718 RHKQEVRRLKSLHEAE--LLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRF 775
+ K ++ RL + E E LQ +R +++ +A RE+ ER +E + E+E ARQ
Sbjct: 750 QDKLDLNRLVAQLEEEKSALQGRQRQAEQ---EATVAREEQERLEEL--RLEQEVARQGL 804
Query: 776 QQHL---EQEQWALQQQRQRLYSEVAEERERLGQ---QAARQRAELEELRQQLEESSSAL 829
+ L EQ Q AL+QQ L E ++ +E+L Q Q + + ELE+ R++ + AL
Sbjct: 805 EGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEAL 864
Query: 830 TRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEI 889
RA R E+E + Q + ER+ GRT EEA L E+E E
Sbjct: 865 ERAAR--------EKEALAKEHAGLAVQLVAAERE----GRTLSEEATRLRLEKEALE-- 910
Query: 890 RKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCS 949
G E++ + +LE A+ E +A + ++ EL+ L Q QE+ S
Sbjct: 911 --GSLFEVQRQLAQLE-----ARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKAS 963
Query: 950 ---ELKGQ-LGEAEGE---NLRLQGLVRQK--ERALEDAQAVNEQLSSERSNLAQVIRQE 1000
EL Q L +AE E +LR Q ++ +R + +A +L +ER+ L +++E
Sbjct: 964 LDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQRE 1023
Query: 1001 FEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSL 1051
E+ LA E E + E+A LQ + L + AL+ KE ++L
Sbjct: 1024 QEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTAL 1074
Score = 98.2 bits (243), Expect = 4e-20
Identities = 168/647 (25%), Positives = 279/647 (43%), Gaps = 115/647 (17%)
Query: 503 EKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQD-QLDSQQEGWVPEAGPGPLE 561
+ KLSA E L L +++ L+E + + Q Q ++QE V LE
Sbjct: 736 DSLSKLSALNESLAQDKL----DLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLE 791
Query: 562 ---LGSEVSTSVMRLKLEVEEKKQAML------------LLQRALAQQRDLTARRVKETE 606
L EV+ + L V E+ Q L LQ LAQ + R +E E
Sbjct: 792 ELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELE 851
Query: 607 KALSRQLQRQRE-------HYEATIQRHLAFIDQLI---EDKKVLSEKCEAVVAELKQ-- 654
+A R+ QRQ E EA + H QL+ + + LSE+ + E +
Sbjct: 852 QA-RREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALE 910
Query: 655 ----EDQRCTERVAQAQAQHELEIKKL---KELMSATEKARREKWIS--EKTKKIKEVTV 705
E QR ++ + Q E E + L KE ++ R++ I+ EK KE+
Sbjct: 911 GSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMA 970
Query: 706 RGL-------EPEIQKLIARHKQEVRRLKSLHEA---ELLQSDERASQRCLRQAEELREQ 755
+ L + +++ A H+++++RL+ EA EL + + R+ EEL +
Sbjct: 971 QKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLAR 1030
Query: 756 LEREKEALG------QQERER----ARQRFQQHL---EQEQWA----------------L 786
LE EKE L QQER+ A QQ L E E+ A L
Sbjct: 1031 LEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISL 1090
Query: 787 QQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQER 846
+ +RQ+ ++ +E++R A +EL +LR Q EE+++A + +R E+ R+ ++
Sbjct: 1091 EMERQKRDAQSRQEQDRSTVNAL--TSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQ 1148
Query: 847 RHQM-----ELNTLKQQLE-----LERQAWEAGRTRKE--EAWLLNREQ--ELREEIRKG 892
R EL T + LE L R+ EA R +E E + R++ ELR + +G
Sbjct: 1149 RDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEG 1208
Query: 893 RDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELK 952
+ L E A+ K ESE+ + +K + E +L+ LE++ + + EL+
Sbjct: 1209 AKEREALRRSNEELRSAVKKAESERIS---LKLANEDKEQKLALLEEARTAVGKEAGELR 1265
Query: 953 GQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEET 1012
L E E L + R L++ + + L SE + L + + E + RLA E
Sbjct: 1266 TGLQEVERSRL-------EARRELQELRRQMKMLDSENTRLGREL-AELQGRLALGERAE 1317
Query: 1013 RQAKAELATLQARQQL-----ELEEVHRRVKTALARKEEAVSSLRTQ 1054
++++ E TL RQ+L LE + + ++ A + +E RT+
Sbjct: 1318 KESRRE--TLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTR 1362
Score = 96.7 bits (239), Expect = 1e-19
Identities = 141/588 (23%), Positives = 254/588 (43%), Gaps = 100/588 (17%)
Query: 546 SQQEGWVPEAGPGPLELGSE----VSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARR 601
S G P GP P S + +++ + +L+V++ + Q L R +
Sbjct: 500 SPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDS 559
Query: 602 VKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTE 661
E +AL QLQR R+ + +Q H ED + ++ + L +E
Sbjct: 560 ESE-RRALEEQLQRLRDKTDGAMQAH--------EDAQREVQRLRSANELLSREKSNLAH 610
Query: 662 RVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQ 721
+ AQ Q E ++ ++L +A E+ RR++ ++ ++ +E V+ ++L H+Q
Sbjct: 611 SLQVAQQQAEELRQEREKLQAAQEELRRQR---DRLEEEQEDAVQDGARVRRELERSHRQ 667
Query: 722 --EVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQ-H 778
++ +S+ EL++ E S+ L Q + L+ + EAL + E R
Sbjct: 668 LEQLEGKRSVLAKELVEVREALSRATL-QRDMLQAEKAEVAEALTKAEAGRVELELSMTK 726
Query: 779 LEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSAL---TRALRA 835
L E+ +LQ +L L + A+ + +L L QLEE SAL R
Sbjct: 727 LRAEEASLQDSLSKL--------SALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQ 778
Query: 836 EFEKGREEQERRHQMELNT------LKQQLELERQAWEA----------GRTRKEE---- 875
E REEQER ++ L L+ L + QA EA R++ +E
Sbjct: 779 EATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 838
Query: 876 --AWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAE------------- 920
L REQEL E+ R+ +++E + ALAKE + A +
Sbjct: 839 LSRQLSGREQEL-EQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSE 897
Query: 921 --SRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENL---------RLQGLV 969
+R++ ++ E L E+++ +L+ R +L EAEG+ L L GL
Sbjct: 898 EATRLRLEKEALEGSLFEVQRQLAQLEARREQL-----EAEGQALLLAKETLTGELAGL- 951
Query: 970 RQKERALEDAQAVNEQLSSERSNLAQVIRQ---EFEDRLAASEEET-----------RQA 1015
RQ+ A ++ +++++L +++ L Q R+ ++ AA EE+ R+
Sbjct: 952 RQQIIATQEKASLDKELMAQK--LVQAEREAQASLREQRAAHEEDLQRLQREKEAAWREL 1009
Query: 1016 KAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRAD 1063
+AE A LQ++ Q E EE+ R++ E +++L+ + + + A+
Sbjct: 1010 EAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE 1057
Score = 86.7 bits (213), Expect = 1e-16
Identities = 119/496 (23%), Positives = 225/496 (45%), Gaps = 76/496 (15%)
Query: 611 RQLQRQREHYE---ATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQ 667
R QR+R+ + + R LA ++ + + + + VAE ++ + R++ Q
Sbjct: 1519 RSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQ 1578
Query: 668 AQHELEIKKLKELMSATEKARR----EKWISEKTKKIKEVTVRGLEPEIQKLIARHKQ-- 721
A+ L+ +E + +E+ RR + E++ + E +R + +I K+ A +
Sbjct: 1579 AELALQ----EESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLE 1634
Query: 722 -EVRRLKSLHEAELLQSDERASQRCLRQAEELREQL---EREKEALGQQERERARQRFQQ 777
+ RRLK + +A ++ + QR + E R +L +RE +A Q+R + QR
Sbjct: 1635 GDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVA 1694
Query: 778 HLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSAL--TRALRA 835
E + LQ +RL +A+ E G R ++ L + L +SS++L TR
Sbjct: 1695 DSEVKAGTLQLTVERLNGALAKVEESEGAL----RDKVRGLTEALAQSSASLNSTRDKNL 1750
Query: 836 EFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDK 895
+K E Q+ L+++L+ RQA RK+ + L + Q LR E+
Sbjct: 1751 HLQKALTACEHDRQV----LQERLDAARQA--LSEARKQSSSLGEQVQTLRGEVA----- 1799
Query: 896 EIELVIHRLEADMALA--------KEESEKAAESRIKRLRDKYEAELSELEQSERKLQER 947
+L + R+EA+ L ++E E AA + +++L+D E L++ LQ
Sbjct: 1800 --DLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQD----ERRLLQERLGSLQRA 1853
Query: 948 CSELKGQLGEAEGENLRLQG-----------LVRQKERALEDAQAVNEQLSSERSNLAQV 996
++L+ + E E LRL+ + R+K R+ ED +LS+E+ L +
Sbjct: 1854 LAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV----RLSAEKGRLDRT 1909
Query: 997 IRQEFEDRLAASEEETRQAKAELATLQA------------RQQLELEEVHRRVKTALARK 1044
+ E LA ++ + +Q +A++ L+ +QQLEL++ R+++A A+
Sbjct: 1910 LTGA-ELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQT 1968
Query: 1045 EEAVSSLRTQHEAAVK 1060
E + + H V+
Sbjct: 1969 ERTLEARERAHRQRVR 1984
Score = 81.3 bits (199), Expect = 5e-15
Identities = 131/542 (24%), Positives = 233/542 (42%), Gaps = 68/542 (12%)
Query: 573 LKLEVEEKKQAMLLLQRALAQQR--------DLTARRVKETEKALSRQLQRQREHYEATI 624
L+ ++EE+ + +L ++ LAQQ+ DL+AR V E A+ R ++ E
Sbjct: 363 LQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSAR-VTELGLAVKRLEKQNLEK----- 416
Query: 625 QRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSAT 684
DQ+ +D L+EK EA+ + L+ ++Q E Q L + L + + +
Sbjct: 417 -------DQVNKD---LTEKLEALES-LRLQEQAALETEDGEGLQQTL--RDLAQAVLSD 463
Query: 685 EKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLK----------------- 727
++ + SE+T ++RGL + R R
Sbjct: 464 SESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLAL 523
Query: 728 ---SLHEAELLQSDER----ASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLE 780
+LH+ +L D R ASQ L + E E+ AL +++ +R R + ++
Sbjct: 524 IHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRAL-EEQLQRLRDKTDGAMQ 582
Query: 781 QEQWALQQQRQRLYSE---VAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEF 837
+ A Q++ QRL S ++ E+ L + + EELRQ+ E+ +A LR +
Sbjct: 583 AHEDA-QREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAA-QEELRRQR 640
Query: 838 EKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEI 897
++ EEQE Q + + + ELER + + + + L E+RE + + +
Sbjct: 641 DRLEEEQEDAVQ---DGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRD 697
Query: 898 ELVIHRLEADMALAKEESEKAA-ESRIKRLRDK---YEAELSELEQSERKLQERCSELKG 953
L + E AL K E+ + E + +LR + + LS+L L + +L
Sbjct: 698 MLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNR 757
Query: 954 QLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETR 1013
+ + E E LQG RQ E+ A+ E+L R +V RQ E L +E+
Sbjct: 758 LVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLE-QEVARQGLEGSLRVAEQAQE 816
Query: 1014 QAKAELATLQ---ARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLE 1070
+ +L TL+ ++ Q +L ++ R++ E+A + Q EA + A E L +
Sbjct: 817 ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAK 876
Query: 1071 QH 1072
+H
Sbjct: 877 EH 878
Score = 80.5 bits (197), Expect = 8e-15
Identities = 162/738 (21%), Positives = 283/738 (38%), Gaps = 109/738 (14%)
Query: 282 QVQRRGAGAARLEHLLQAKRE----EQRQRSGEGTLLDLHQQKEAARRKAREEKAR---- 333
++Q R A R E +++RE QR GE +L + Q+ + A+RK +E++
Sbjct: 1305 ELQGRLALGERAEK--ESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTR 1362
Query: 334 ---------QARRAAIQELQQKRALR----AQKASTAERGPPENPRETRVPGMR------ 374
+AR Q+L R L A +A AE G + E R G+
Sbjct: 1363 ERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARV 1422
Query: 375 QPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQ 434
+ + + G AL+ G P+ P R +P SP P E + + +
Sbjct: 1423 EVQRRAAEAQLGGLRSALRRGLGLGRAPSPAP--RPVP---GSPARDAPAEGSGEGLNSP 1477
Query: 435 DAAGDNLEMMAPSRGSAKS-----------RGPLEELLHTLQLLEKEPDVLPRPRTHHRG 483
+ PS G A S RG L E L L+ ++E D L +
Sbjct: 1478 STLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNR 1537
Query: 484 RYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS-EAKLQSIMSFLDEMEKSGQD 542
+ A E D+++ A L+K S DG L +A+L + E+ +
Sbjct: 1538 QLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRA 1597
Query: 543 QLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRV 602
LD LE + + S +R E K +A + + V
Sbjct: 1598 TLDQV----------ATLERSLQATESELRASQEKISKMKA----NETKLEGDKRRLKEV 1643
Query: 603 KETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQED------ 656
+ ++ + +L+ QR E +QR + + L ++ +++ ++ +
Sbjct: 1644 LDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTL 1703
Query: 657 QRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLI 716
Q ER+ A A+ E L++ + +A +++ + + + L +
Sbjct: 1704 QLTVERLNGALAKVEESEGALRDKVRGLTEA-----LAQSSASLNSTRDKNLHLQKALTA 1758
Query: 717 ARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQ-----LER-EKEALGQQERER 770
H ++V + + + L + S Q + LR + L+R E E QQ RE
Sbjct: 1759 CEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREV 1818
Query: 771 ARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALT 830
RQR ++ + A Q+L E +ERLG R A+LE ++++E S+ L
Sbjct: 1819 LRQR-----QEGEAAALNTVQKLQDERRLLQERLGS-LQRALAQLEAEKREVERSALRLE 1872
Query: 831 R---ALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELRE 887
+ ALR +K E+ R H+ + ++ L+R L E EL E
Sbjct: 1873 KDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRT-------------LTGAELELAE 1919
Query: 888 EIRKGRDKEIELVI---HRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERK- 943
R+ + E ++V+ A + + ++ + + ++RLR LE ER
Sbjct: 1920 AQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAH 1979
Query: 944 ------LQERCSELKGQL 955
L+E+ S LKGQL
Sbjct: 1980 RQRVRGLEEQVSTLKGQL 1997
Score = 64.3 bits (155), Expect = 6e-10
Identities = 114/519 (21%), Positives = 203/519 (39%), Gaps = 74/519 (14%)
Query: 598 TARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIED--KKVLSEKCEAVVAELKQE 655
T+R V+E LS L+ EA +++ QL E KVL EK +A+ + +
Sbjct: 331 TSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKD---LAQQQMQ 387
Query: 656 DQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVR---GLEPE- 711
++ + L +K+L++ EK + K ++EK + ++ + ++ LE E
Sbjct: 388 SDLDKADLSARVTELGLAVKRLEK--QNLEKDQVNKDLTEKLEALESLRLQEQAALETED 445
Query: 712 ---IQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQER 768
+Q+ + Q V L L ER + L Q R
Sbjct: 446 GEGLQQTLRDLAQAV--LSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGR 503
Query: 769 ERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSA 828
R+ +R + L L+ + ++ G+ A Q L LR+QL +S S
Sbjct: 504 GRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDL-LGTLRKQLSDSESE 562
Query: 829 LTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREE 888
RAL + ++ R++ + Q + ++ L R + A L Q+ EE
Sbjct: 563 -RRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEE 621
Query: 889 IRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERC 948
+R+ R+K +AA+ ++R RD+ E E + Q +++
Sbjct: 622 LRQEREKL--------------------QAAQEELRRQRDRLEEEQEDAVQDGARVRREL 661
Query: 949 SELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVI------RQEFE 1002
QL + EG+ L + + AL A + L +E++ +A+ + R E E
Sbjct: 662 ERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELE 721
Query: 1003 -----------------DRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTA----- 1040
+L+A E Q K +L L A+ + E + R + A
Sbjct: 722 LSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT 781
Query: 1041 LARKE-EAVSSLRTQHEAA-------VKRADHLEELLEQ 1071
+AR+E E + LR + E A ++ A+ +E LEQ
Sbjct: 782 VAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQ 820
Score = 60.8 bits (146), Expect = 7e-09
Identities = 217/993 (21%), Positives = 371/993 (37%), Gaps = 174/993 (17%)
Query: 200 KSSNQTAPSLNNIIKAATCEGSESSGFGKLPKNVSSATHSARNNTGGSTGLPRRKEVTEE 259
+S Q LN ++ A E +S+ G+ + AT AR L +EV +
Sbjct: 746 ESLAQDKLDLNRLV--AQLEEEKSALQGRQRQAEQEAT-VAREEQERLEELRLEQEVARQ 802
Query: 260 EAERFIHQVNQATVTIQRWY---RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDL 316
E + QA +++ RH+ + A+L L + +E Q E
Sbjct: 803 GLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREA----- 857
Query: 317 HQQKEAARRKAREEKARQARRA--AIQELQQKRALRA-QKASTAERGPPENPRETRVPGM 373
+Q EA R ARE++A A A+Q + +R R + +T R E +
Sbjct: 858 QRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQ 917
Query: 374 RQPAQ----ELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQ 429
RQ AQ G A K TG AG + + T + + +
Sbjct: 918 RQLAQLEARREQLEAEGQALLLAKETLTG---ELAGLRQQIIATQEKA--------SLDK 966
Query: 430 DVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYA--- 486
+++AQ E A R + R EE LQ L++E + R R +
Sbjct: 967 ELMAQKLVQAEREAQASLR---EQRAAHEE---DLQRLQREKEAAWRELEAERAQLQSQL 1020
Query: 487 WASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDS 546
+E+ + L A+ E +++A + ++G LL+E++ Q +S L E EK+
Sbjct: 1021 QREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS-LKESEKTA------ 1073
Query: 547 QQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQ-RDLTA------ 599
+ E G + +S + R K + + +++ AL + RDL A
Sbjct: 1074 -----LSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAA 1128
Query: 600 -------RRVKETEKALSRQLQR-QREHYEATIQRHL------AFIDQLIEDKKVLSEKC 645
RR++E + L +Q RE E Q L +L+E ++ L E
Sbjct: 1129 AAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQ 1188
Query: 646 EAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTV 705
E + +QE + + + E + +EL SA +KA E+ + + KE +
Sbjct: 1189 EGREVQ-RQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKL 1247
Query: 706 RGLEP-------------------EIQKLIARHK-QEVRRLKSLHEAE------------ 733
LE E +L AR + QE+RR + ++E
Sbjct: 1248 ALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQ 1307
Query: 734 -LLQSDERASQRCLRQA--------------EELREQLEREKEALGQQE-----RER--- 770
L ERA + R+ E +R++L+ + L +QE RER
Sbjct: 1308 GRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLL 1367
Query: 771 -----ARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQR------AELEELR 819
AR +Q L+ + L+ + + +E AE RL R + A +E R
Sbjct: 1368 GSLEEARGTEKQQLDHAR-GLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQR 1426
Query: 820 QQLEESSSALTRALRAEFEKGREEQERRHQMELNT------------LKQQLELE----R 863
+ E L ALR GR + + L LE
Sbjct: 1427 RAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGS 1486
Query: 864 QAWEAGRTRKEEAWLLNRE------QELREEIRKGRDKEIELVIHRLEADMALAKEESEK 917
Q G + L+ E +E +E+R + + EL + LA+ E+E+
Sbjct: 1487 QPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAER 1546
Query: 918 -AAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERAL 976
+A SR ++L + ++E E++ R + R S ++ +L E R + R++ L
Sbjct: 1547 DSATSRARQL----QKAVAESEEARRSVDGRLSGVQAELALQEESVRRSE---RERRATL 1599
Query: 977 EDAQAVNEQLSSERSNLAQVIRQEFEDRLAASE---EETRQAKAELATLQARQQLELEEV 1033
+ + L + S L QE ++ A+E E ++ E+ + ++LE
Sbjct: 1600 DQVATLERSLQATESELR--ASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQ 1657
Query: 1034 HRRVKTALARKEEAVSSLRTQHEAAVKRADHLE 1066
R ++ L R +S Q +A R D L+
Sbjct: 1658 RRSLEGELQRSRLGLSDREAQAQALQDRVDSLQ 1690
Score = 60.5 bits (145), Expect = 9e-09
Identities = 132/603 (21%), Positives = 246/603 (40%), Gaps = 109/603 (18%)
Query: 533 LDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEV-EEKKQAMLLLQRAL 591
L E + S + +L + QEG +A V RL+ ++ + KK+ L Q+ L
Sbjct: 148 LQEEQASYRRKLQAYQEGQQRQA------------QLVQRLQGKILQYKKRCSELEQQLL 195
Query: 592 AQQRDLTARRVKETEKA--LSRQLQRQREHYE--ATIQRHLAFIDQLIEDKKVLSEKCEA 647
+ +L +R+++TE + L L R E + A++ + A + + ++ ++
Sbjct: 196 ERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSE 255
Query: 648 VVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKW-----ISEKTKKIKE 702
+ ++ + RC + + +A E + S W ++K
Sbjct: 256 DIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKM 315
Query: 703 VTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQA-------EELREQ 755
T R L ++ +AR + V+ L ++ RA +QA E+LR++
Sbjct: 316 FTERDL-LQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDK 374
Query: 756 LEREKEALGQQERERARQRFQ------------QHLEQEQWALQQQRQRLYSEV-AEERE 802
+ REK+ L QQ+ + + + LE++ Q + L ++ A E
Sbjct: 375 VLREKD-LAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL 433
Query: 803 RLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGRE--EQERRHQMELNTLK---- 856
RL +QAA + + E L+Q L + L +A+ ++ E G + ER +L+
Sbjct: 434 RLQEQAALETEDGEGLQQTLRD----LAQAVLSDSESGVQLSGSERTADASNGSLRGLSG 489
Query: 857 QQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESE 916
Q+ + GR R R D +IH AL K + +
Sbjct: 490 QRTPSPPRRSSPGRGRSPR----------RGPSPACSDSSTLALIH-----SALHKRQLQ 534
Query: 917 KAAESRIKRLRDKYEA----------ELSELEQSERKLQERCSELKGQLGEAEGENLRLQ 966
++ +R +YEA +LS+ E R L+E+ L+ + A +
Sbjct: 535 ------VQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAH---- 584
Query: 967 GLVRQKERALEDAQAVNEQLSSERSNLA---QVIRQEFE------DRLAASEEETRQAKA 1017
+R ++ ++ NE LS E+SNLA QV +Q+ E ++L A++EE R+ +
Sbjct: 585 ---EDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRD 641
Query: 1018 ELATLQ-------ARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLE 1070
L Q AR + ELE HR+++ L K ++ + A+ RA ++L+
Sbjct: 642 RLEEEQEDAVQDGARVRRELERSHRQLE-QLEGKRSVLAKELVEVREALSRATLQRDMLQ 700
Query: 1071 QHR 1073
+
Sbjct: 701 AEK 703
Score = 56.6 bits (135), Expect = 1e-07
Identities = 108/454 (23%), Positives = 195/454 (42%), Gaps = 67/454 (14%)
Query: 662 RVAQAQAQHELEIKKLKELMSATEKA------RREKWISEKTKKIKEVTVRGL-EPEIQK 714
R + + E I+ L+ + EK ++ I+ I+E+ R L +PE
Sbjct: 7 RAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPV 66
Query: 715 LIARHKQEVRRLKSLHEA-ELLQSDERASQRCLRQAEELREQL--------EREKEAL-- 763
L+ E+ L SL E +LLQ + + L Q+ R++L ER ++AL
Sbjct: 67 LLP--ATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRL 124
Query: 764 --GQQERERARQRFQQHLE-----QEQWALQQQRQRLYSEVAEER----ERLGQQAARQR 812
G+ E + R +Q +E QE+ A +++ + Y E + + +RL + + +
Sbjct: 125 EPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYK 184
Query: 813 AELEELRQQLEESSSAL----------TRALRAEFEKGREEQERRHQM-ELNT-LKQQLE 860
EL QQL E S L ++ L + + EEQ+R + ++N L++QL+
Sbjct: 185 KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLD 244
Query: 861 LERQAWEAGRTRKEEA------WL-LNREQELREEIRKGRDKEIELVIHRLEADMALAKE 913
QA A + E+ W +E E RE + ++ + + L
Sbjct: 245 ---QAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWR 301
Query: 914 E--SEKAAESRIKRLRDKYEAEL-SELEQSERKLQERCSELKGQLGEAEGENLRLQGLVR 970
+ + S +K ++ +L EL ++ R +QE L L AE +
Sbjct: 302 QVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAES-----RAEAA 356
Query: 971 QKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQ-ARQQLE 1029
+++AL AQ + EQL + + +Q+ + L ++ R + LA + +Q LE
Sbjct: 357 LEKQALLQAQ-LEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLE 415
Query: 1030 LEEVHRRVKTALARKEEAVSSLRTQHEAAVKRAD 1063
++V++ L K EA+ SLR Q +AA++ D
Sbjct: 416 KDQVNK----DLTEKLEALESLRLQEQAALETED 445
Score = 49.3 bits (116), Expect = 2e-05
Identities = 70/314 (22%), Positives = 130/314 (41%), Gaps = 43/314 (13%)
Query: 785 ALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQ 844
+LQ++ Q L E++ + L Q RAE +EL + S L +ALR E + ++
Sbjct: 78 SLQEENQLLQQELSRVEDLLAQS----RAERDELAIKYNAVSERLEQALRLEPGELETQE 133
Query: 845 ERRHQMELNTLKQQLELER-------QAWEAGRTRKEEAWLLNR---------------E 882
R + L++QL+ E+ QA++ G+ R +A L+ R E
Sbjct: 134 PRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQR--QAQLVQRLQGKILQYKKRCSELE 191
Query: 883 QELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSER 942
Q+L E + + + H + + AL + E E+ + + ++ +L + + +
Sbjct: 192 QQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQ 251
Query: 943 KLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFE 1002
L E ++ E + R++E ++ N S+E S L + RQ
Sbjct: 252 ALSEDIRKVTNDWTRCRKELEHREAAWRREE------ESFNAYFSNEHSRLLLLWRQVVG 305
Query: 1003 DRLAASEEE--TRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVK 1060
R SE + T + +L AR ++E + T L E ++ EAA++
Sbjct: 306 FRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAE-------SRAEAALE 358
Query: 1061 RADHLEELLEQHRR 1074
+ L+ LE+ R
Sbjct: 359 KQALLQAQLEEQLR 372
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 108 bits (269), Expect = 4e-23
Identities = 122/544 (22%), Positives = 261/544 (47%), Gaps = 59/544 (10%)
Query: 438 GDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSL 497
G+ ++++ S K G LE+ L + +K+ D T R S E +++
Sbjct: 158 GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDAL---SLELYRNTI 214
Query: 498 TADNL-EKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAG 556
T + L EK KL E L+ K + ++ + K + +L Q+ EA
Sbjct: 215 TDEELKEKNAKLQ------EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD 268
Query: 557 PGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTAR---RVKETEKALSRQL 613
LG E+ + +L+ +VEE + L R QQ + R +++E E+ + Q
Sbjct: 269 ----HLGKELQSVSAKLQAQVEENE----LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE 320
Query: 614 QRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAV--VAELKQEDQRCTERVAQAQAQHE 671
++ RE E ++ +++ ++++ EK E + E+ E + R+ + + E
Sbjct: 321 EKIREQEEKIREQE----EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKE 376
Query: 672 LEIKKLKELMSATEKARREKWISEKTKKIKEVTVRG------------LEPEIQKLIARH 719
+I++L+E M EK R ++ ++ +KI+E R + + +K+ +
Sbjct: 377 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 436
Query: 720 KQEVRRLKSLHEAELLQSDERASQR--CLRQAEELREQLE--REKEALGQQERERARQ-- 773
K+ R+ + +HE E ++ +E+ ++ RQ E++REQ E R+KE + +QE+ R ++
Sbjct: 437 KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEK 496
Query: 774 --RFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTR 831
R ++ + ++ +++Q ++++ + E++ +Q + R + E++R+Q EE
Sbjct: 497 VWRQEEKMHDQEEKIREQEEKMW----RQEEKIREQEEKIREQEEKIREQ-EEMMQEQEE 551
Query: 832 ALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRK 891
+ + EK +E+++ R Q E +++Q E R+ E R ++E+ W +E+++RE+
Sbjct: 552 KMGEQEEKMQEQEKMRRQEE--KIREQEEKIREQKEKIREQEEKIW--EQEEKIREQEEM 607
Query: 892 GRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSEL 951
+++E ++ + + +EE + E +++R +K + L Q E K+QE L
Sbjct: 608 MQEQEEKMWE---QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Query: 952 KGQL 955
+ +
Sbjct: 665 EAAI 668
Score = 99.0 bits (245), Expect = 2e-20
Identities = 128/572 (22%), Positives = 248/572 (43%), Gaps = 96/572 (16%)
Query: 561 ELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQ----QRDLTARR------VKETEKALS 610
EL ++V T + L + E + A+ Q A+ Q RDL +R E E+ALS
Sbjct: 124 ELEAQVHT-IRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALS 182
Query: 611 -------------RQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAV--------- 648
+L ++R+ + R+ ++L E L EK + V
Sbjct: 183 AVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQL 242
Query: 649 -VAELKQEDQRCTERVAQAQAQHELEI--KKLKELMSATEKARREKWISEKTKKIKEVTV 705
V ELK++ +R + Q Q Q E + K+L+ + + + E + + + +E +
Sbjct: 243 NVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKM 302
Query: 706 RGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQ 765
E +IQ+ + +++ +++ + E ++ E +R E E++ R++E + +
Sbjct: 303 WRQEEKIQEWEEKIQEQEEKIRE--QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360
Query: 766 QERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEES 825
+E + R LE+ W +++ + L E E+E++ +Q +++ E E++R+Q E+
Sbjct: 361 KEEKMRR------LEEMMWEKEEKIREL-EEKMHEQEKIREQEEKRQEE-EKIREQ-EKR 411
Query: 826 SSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAW---EAGRTRKEEAWLLNRE 882
+ R E EK RE++E+ + E +Q+ ++ Q E R +EE W +E
Sbjct: 412 QEQEAKMWRQE-EKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMW--RQE 468
Query: 883 QELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDK------------- 929
+++RE+ R KE + ++E + E ++ R +K
Sbjct: 469 EKIREQEEIWRQKE------------KMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEE 516
Query: 930 -----------YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALED 978
E ++ E E+ R+ +E E + ++GE E + + + RQ+E+ E
Sbjct: 517 KMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQ 576
Query: 979 AQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVK 1038
+ + EQ R ++ QE + R +EE Q + E Q + E EE + +
Sbjct: 577 EEKIREQKEKIREQEEKIWEQEEKIR---EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 633
Query: 1039 TALARKEEAV----SSLRTQHEAAVKRADHLE 1066
+ R+EE + LR Q E + +HLE
Sbjct: 634 EKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 88.6 bits (218), Expect = 3e-17
Identities = 106/467 (22%), Positives = 216/467 (46%), Gaps = 38/467 (8%)
Query: 631 IDQLIEDKKVLSEKCEAVVAEL-KQEDQRCTERVAQAQAQHELEIK--KLKELMSATEKA 687
++Q + +K + + EL K+ D E EL+ K KL+E + E
Sbjct: 177 LEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESE 236
Query: 688 RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLR 747
+ E ++ K K K + L P+ Q+L A + L+S+ Q +E L
Sbjct: 237 KSEIQLNVKELKRKLERAKLLLPQ-QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLN 295
Query: 748 QAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQ 807
Q +E E++ R++E + + E + Q + ++E+ Q+++ R E+ E+E ++
Sbjct: 296 QQQE--EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE---EK 350
Query: 808 AARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQME-LNTLKQQLELERQAW 866
RQ EE+ + EE L + + EK RE +E+ H+ E + +++ + E +
Sbjct: 351 MRRQ----EEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR 406
Query: 867 EAGRTRKEEAWLLNREQELREEIRKGRDKEIEL-----VIHRLEADMALAKEESEKAAES 921
E + +++EA + +E+++RE+ K R++E ++ IH E K + ++
Sbjct: 407 EQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR 466
Query: 922 RIKRLRDKYE----AELSELEQSERKLQERCSELKGQLGEAEGENLRLQ--GLVRQKERA 975
+ +++R++ E E ++ RK +E+ + ++ + E E +R Q + RQ+E+
Sbjct: 467 QEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQE-EKIREQEEKMWRQEEKI 525
Query: 976 LEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHR 1035
E + + EQ E+ + + QE E+++ E+E + + E Q + E EE R
Sbjct: 526 REQEEKIREQ--EEKIREQEEMMQEQEEKM--GEQEEKMQEQEKMRRQEEKIREQEEKIR 581
Query: 1036 RVKTALARKEEAV----SSLRTQHEAAVKRADHL----EELLEQHRR 1074
K + +EE + +R Q E ++ + + E++ EQ +
Sbjct: 582 EQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 628
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 107 bits (268), Expect = 5e-23
Identities = 125/528 (23%), Positives = 241/528 (45%), Gaps = 62/528 (11%)
Query: 575 LEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQL 634
L++EE+ Q++ A Q R+ + E EK L + H EA +Q+ +L
Sbjct: 620 LQLEEENQSVCSRMEAAEQARNALQVDLAEAEKR-REALWEKNTHLEAQLQKAEEAGAEL 678
Query: 635 IEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWIS 694
D + + E+ E + +L + + Q + H+ E K+ +E+++ +A +EK
Sbjct: 679 QADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ-EAKRQEEVLA---RAVQEKEAL 734
Query: 695 EKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQ----------- 743
+ K EV ++ +E + Q L A Q + K L E+ L ++ ++ S
Sbjct: 735 VREKAALEVRLQAVERDRQDL-AEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQ 793
Query: 744 -RCLRQAEE--------LREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLY 794
+ + QA+E L+ +L+ E+ +QER+ A ++ Q ++ + AL+QQ+
Sbjct: 794 IQTVTQAKEVIQGEVRCLKLELDTERSQ-AEQERDAAARQLAQAEQEGKTALEQQKAAHE 852
Query: 795 SEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALR-----AEFEKGREEQERRH- 848
EV + RE+ ++ + + EL + + LE L L+ E + + E+ER
Sbjct: 853 KEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQA 912
Query: 849 -----QMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHR 903
QM+L T K+++ L + T+KE A + + LR++++ + KE E
Sbjct: 913 ESALCQMQLETEKERVSLLETLLQ---TQKELADASQQLERLRQDMKVQKLKEQE-TTGI 968
Query: 904 LEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENL 963
L+ + A+ E ++AA L E E S L Q + LQ++ +LK QL +
Sbjct: 969 LQTQLQEAQRELKEAARQHRDDLAALQE-ESSSLLQDKMDLQKQVEDLKSQLVAQDDSQR 1027
Query: 964 RLQGLVRQKERALEDAQAVNEQLSSERSNL----------------AQVIRQEFEDRLAA 1007
++ V++K R ++ + ++L E+++L A IRQ+ L+A
Sbjct: 1028 LVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQ---ELSA 1084
Query: 1008 SEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQH 1055
++ ++A+ E L A+ +L +EV + LA++ + + L H
Sbjct: 1085 LRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASH 1132
Score = 96.7 bits (239), Expect = 1e-19
Identities = 206/934 (22%), Positives = 364/934 (38%), Gaps = 168/934 (17%)
Query: 297 LQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKA----------RQARRAAIQELQQK 346
L A R++ ++ GE +L Q E R++ +E++A + + I E Q +
Sbjct: 1082 LSALRQDMQEAQGEQK--ELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139
Query: 347 RALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAH-QALKANNTGGGLPAAG 405
+L AQ+A A+ E+++ + Q PG A QA A+ A G
Sbjct: 1140 ASLWAQEAKAAQLQLRLRSTESQLEALAAEQQ-----PGNQAQAQAQLASLYSALQQALG 1194
Query: 406 PGDRCLPT----SDSSPEPQ--QPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEE 459
P DS+P +P ++ + + + L A + K L +
Sbjct: 1195 SVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWK 1254
Query: 460 LLHTLQLLEKEPDVLPRPRTHHRGRYAWASEE-DDASSLTADNLEKFGKLSAFPEPPEDG 518
T +L + L T + E D + N E+ K E
Sbjct: 1255 TQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESE 1314
Query: 519 TLLSEAKLQSIMSFL-----DEMEKSGQDQL----------------DSQQEGWVPEAGP 557
+ + S+ S L ME G+ +L + E +
Sbjct: 1315 LMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAA 1374
Query: 558 GPLELGSEVSTSVMRLKLEV--EEKKQAMLL-------------LQRALAQQRDLTARRV 602
G LE + S ++LK E E+++A L LQ LA A R
Sbjct: 1375 GILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAERE 1434
Query: 603 KETE--KALSRQLQRQREHYEATIQRHLAFID--------QLIEDKKVLSEKCEAVVAEL 652
+E E + ++L++QRE +A ++ L +D L +++ EKC +V+ L
Sbjct: 1435 EEVETLRGQIQELEKQREMQKAALE--LLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHL 1492
Query: 653 ----KQEDQRCT---ERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKE--- 702
++ +Q+ T E++ + + E + L+ + EK +++ I + ++++
Sbjct: 1493 PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEK--KDQMIESQRGQVQDLKK 1550
Query: 703 --VTVRGLEPEIQKLIARHKQE-----VRRLKSLHEAE------LLQSDERASQRCLRQA 749
VT+ L E+++ HK E ++ L+ E + L E SQ Q+
Sbjct: 1551 QLVTLECLALELEE--NHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQS 1608
Query: 750 EEL-----------REQLEREKEALGQQERERARQRFQQHLEQEQ--------------W 784
++ RE ER++E Q+E+ QR ++HL Q+
Sbjct: 1609 SQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQ 1668
Query: 785 ALQQQRQRLYSEVAEERERLG---QQAARQRAELEELRQQLEESSSALTRALRAEFE--- 838
L+ QR R + E+ E++ ++ R+ +L Q+ E ++A R E
Sbjct: 1669 VLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK 1728
Query: 839 -----KGRE-EQERRHQMELNTLKQQLELERQAW--EAGRT----RKEEAWLLNREQELR 886
K +E E ++ H EL LK QLE + Q + G T + E ++ +Q+L+
Sbjct: 1729 LILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQ 1788
Query: 887 EEIRKGRDKEIELVIHRLEADMALAKEESE--------KAAESRIKRLRDKYEAELSELE 938
E +G KE L EA ALA+ + E + A+ + +R+++K +A LE
Sbjct: 1789 EAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE 1848
Query: 939 QSERKLQERCSELKGQLGEAEG-------ENLRLQGL------VRQKERALEDAQAVNEQ 985
Q+ L+ER EL+ +A E R+Q L +R + R E A +Q
Sbjct: 1849 QAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQ 1908
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKE 1045
+E++ +V + +D ++ ++ EL L+A E + + + A AR E
Sbjct: 1909 QCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRA----ESQSSRHQEEAARARAE 1964
Query: 1046 EAVSSLRTQHEAAVKRADHLEELLEQHRRPTPST 1079
+L H A + HL E E R ST
Sbjct: 1965 ALQEALGKAHAALQGKEQHLLEQAELSRSLEAST 1998
Score = 95.1 bits (235), Expect = 3e-19
Identities = 130/536 (24%), Positives = 239/536 (44%), Gaps = 73/536 (13%)
Query: 565 EVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSR-QLQRQREHYEAT 623
E+ L ++E + Q ++L + + D R+ K E+ L + +L + E T
Sbjct: 1641 ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELT 1700
Query: 624 IQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSA 683
QR L + + E+ K S+ + +K R E+ + Q +H E+++LK+ +
Sbjct: 1701 TQRQL--MQERAEEGKGPSKAQRGSLEHMKLI-LRDKEKEVECQQEHIHELQELKDQL-- 1755
Query: 684 TEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK-QEVRRLKSLHEAELLQSDERAS 742
E+ + +K+ E ++ + E + ++ + + QE R L E + LQS +
Sbjct: 1756 ------EQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKE-QSLQSQLDEA 1808
Query: 743 QRCLRQAEELREQLEREKE-ALGQQERERAR-QRFQQHLEQEQWALQQQRQRLYSEVAEE 800
QR L Q ++ E L++E++ A GQ+ER + + Q LEQ L+++ L + E+
Sbjct: 1809 QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGEL-QDHKEQ 1867
Query: 801 RERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLE 860
RL ++ A + ++ L + L + LRAE R + L L+QQ
Sbjct: 1868 ARRLEEELAVEGRRVQALEEVLGD--------LRAE--------SREQEKALLALQQQCA 1911
Query: 861 LERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAE 920
+ Q E +++WL + + K RD+E+E + R E+ + +EE+ +A
Sbjct: 1912 EQAQEHEVETRALQDSWL------QAQAVLKERDQELEAL--RAESQSSRHQEEAARARA 1963
Query: 921 SRIKRLRDKYEAELSE-----LEQSE--RKLQERCSELKGQLGEAEGENLRLQGLVRQKE 973
++ K A L LEQ+E R L+ + L+ L + + +L+ +R +E
Sbjct: 1964 EALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQE 2023
Query: 974 --------RALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAAS-----EEETRQAKAELA 1020
R ED Q + + L+ L +QE E L S +E Q K L
Sbjct: 2024 GEIQDQDLRYQEDVQQLQQALAQRDEELRH--QQEREQLLEKSLAQRVQENMIQEKQNLG 2081
Query: 1021 TLQARQQLELEEVH---RRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHR 1073
Q R++ E+ +H R ++ LA+KE+ + LR ++ ++LE L H+
Sbjct: 2082 --QEREEEEIRGLHQSVRELQLTLAQKEQEILELR-----ETQQRNNLEALPHSHK 2130
Score = 94.0 bits (232), Expect = 7e-19
Identities = 190/897 (21%), Positives = 363/897 (40%), Gaps = 126/897 (14%)
Query: 249 GLPRRKEVTEEEAERFIHQVN---QATVTIQRWYRHQVQRRGAGAARLEHL-LQAKREEQ 304
GL ++ EEE + ++ QA +Q +RR A + HL Q ++ E+
Sbjct: 614 GLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEE 673
Query: 305 RQRSGEGTLLDLHQQKEAARRKAREEKARQ-ARRAAIQELQQK---------RALRAQKA 354
+ L D+ ++KE ++K E + +Q A +++L Q+ RA++ ++A
Sbjct: 674 AGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEA 733
Query: 355 STAERGPPENPRETRVPGMRQPAQELSPTPGG--TAHQALKANNTGGGLPAAGPGDRCLP 412
E+ E R+ + + Q+L+ G +A + L+++ L A + +
Sbjct: 734 LVREKAA----LEVRLQAVERDRQDLAEQLQGLSSAKELLESS-----LFEAQQQNSVIE 784
Query: 413 TSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPD 472
+ E Q + ++V+ + LE+ + +S+ E QL + E +
Sbjct: 785 VTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL-----DTERSQAEQERDAAARQLAQAEQE 839
Query: 473 ---VLPRPRTHHRG-----RYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEA 524
L + + H R W E A LE L
Sbjct: 840 GKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALES----------------LERE 883
Query: 525 KLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAM 584
K++ M ++ + Q ++E E+ ++L +E V L+ ++ +K+
Sbjct: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETE-KERVSLLETLLQTQKELA 942
Query: 585 LLLQRALAQQRDLTARRVKETEKA--LSRQLQR-QREHYEATIQRH--LAFIDQ----LI 635
Q+ ++D+ +++KE E L QLQ QRE EA Q LA + + L+
Sbjct: 943 DASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLL 1002
Query: 636 EDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISE 695
+DK L ++ E + ++L +D ++R+ + + Q +L ++ +E ++ REK
Sbjct: 1003 QDKMDLQKQVEDLKSQLVAQDD--SQRLVEQEVQEKL--RETQEYNRIQKELEREK---- 1054
Query: 696 KTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQ 755
+T+ +E E + L+ + +R+ + + +Q + + Q E LR++
Sbjct: 1055 -----ASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQE 1109
Query: 756 L-EREKEALGQQ----ERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAAR 810
+ E+E + L Q+ E A +Q L WA + + +L + +L AA
Sbjct: 1110 VKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAE 1169
Query: 811 QR-AELEELRQQLEESSSALTRAL------RAEFEKGREEQERRHQME------------ 851
Q+ + + QL SAL +AL R E G + +E
Sbjct: 1170 QQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKR 1229
Query: 852 ---LNTLKQQL------ELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 902
L L + +L + W+ +TR L ++ Q+L E + ++ ++
Sbjct: 1230 GPLLTALSAEAVASALHKLHQDLWKTQQTRDV---LRDQVQKLEERLTDTEAEKSQVHTE 1286
Query: 903 RLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGEN 962
+ L++ + EK S+ + ++ E+EL EL ++ LQ R + Q EA+GE
Sbjct: 1287 LQDLQRQLSQNQEEK---SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGER 1343
Query: 963 LRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAA---------SEEETR 1013
LQ +E QA + ++ S A ++ ++ +A SE E
Sbjct: 1344 ELLQAAKENLTAQVEHLQAAVVEARAQAS-AAGILEEDLRTARSALKLKNEEVESERERA 1402
Query: 1014 QAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLE 1070
QA E L+ Q L+E + LA +EE V +LR Q + K+ + + LE
Sbjct: 1403 QALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALE 1459
Score = 75.5 bits (184), Expect = 3e-13
Identities = 183/865 (21%), Positives = 326/865 (37%), Gaps = 127/865 (14%)
Query: 234 SSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQ---RRGAGA 290
SS H ++ ST L R + ++E + Q+ + +QR H Q RR
Sbjct: 1608 SSQIHDLESH---STVLARELQERDQEVKSQREQIEE----LQRQKEHLTQDLERRDQ-- 1658
Query: 291 ARLEHLLQAKR----EEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQK 346
E +LQ +R E+QR R + DL Q K + R + RE ++ +L Q+
Sbjct: 1659 ---ELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQR-------QLMQE 1708
Query: 347 RALRAQKASTAERGPPEN------PRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGG 400
RA + S A+RG E+ +E V ++ EL Q +
Sbjct: 1709 RAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK--- 1765
Query: 401 LPAAGPGDRCLPTSDSSPE----PQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGP 456
G+ L S E QQ E R Q L + + +
Sbjct: 1766 -----VGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSL----------------QSQ 1804
Query: 457 LEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPE 516
L+E L ++E + L + + +G+ E+ DA
Sbjct: 1805 LDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADA---------------------- 1842
Query: 517 DGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLE 576
L A Q+ M+ E+ G+ Q +Q + E + + L+ E
Sbjct: 1843 ----LQGALEQAHMTL---KERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAE 1895
Query: 577 VEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIE 636
E+++A+L LQ+ A+Q + + +R LQ +A ++ ++ L
Sbjct: 1896 SREQEKALLALQQQCAEQA--------QEHEVETRALQDSWLQAQAVLKERDQELEALRA 1947
Query: 637 DKKVLSEKCEAVVA--ELKQEDQRCTERVAQAQAQHELEIKKL-KELMSATEKARREKWI 693
+ + + EA A E QE Q + QH LE +L + L ++T +
Sbjct: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDA 2007
Query: 694 SEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSL---HEAELLQSDERASQRCLRQAE 750
+ + E +R E EIQ R++++V++L+ + EL ER A+
Sbjct: 2008 CQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQ 2067
Query: 751 ELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAA- 809
++E + +EK+ LGQ+ E + Q + + Q L Q+ Q + E+ E ++R +A
Sbjct: 2068 RVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEIL-ELRETQQRNNLEALP 2126
Query: 810 ---------RQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLE 860
Q +L+ L +L+ L ALR + E +E+ + L+ + +
Sbjct: 2127 HSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKAS 2186
Query: 861 LERQAWEAGRTRKEEAWLLNREQELREEI---RKGRDKEIELVIHRLEADMALAKEESEK 917
+ A + + +Q L++E+ R+ +KE RL + A + E
Sbjct: 2187 VSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE------RLHSPGATSTAELGS 2240
Query: 918 AAESRIKRLR-DKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERAL 976
E ++ EAE S ++ ++R L+ + E + RLQ Q L
Sbjct: 2241 RGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTL 2300
Query: 977 EDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRR 1036
E + +L E AQ E A+S + + + + +L+ E V +
Sbjct: 2301 EQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQ 2360
Query: 1037 VKTALARKEE---AVSSLRTQHEAA 1058
+ L RK++ S +T E A
Sbjct: 2361 AQLTLERKQKQDYITRSAQTSRELA 2385
Score = 74.3 bits (181), Expect = 6e-13
Identities = 111/483 (22%), Positives = 212/483 (43%), Gaps = 61/483 (12%)
Query: 647 AVVAELKQEDQRCTERVAQAQAQHELEIKKLK----ELMSATEKARREKWISEKTKKIKE 702
A EL++E ++ + Q ++Q +LE +L+ EL + +++++ EK K
Sbjct: 251 AKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALR 310
Query: 703 VTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELRE------QL 756
TV LE +L+ H+ + R + L Q + +Q + + + + + L
Sbjct: 311 ETVEILETNHTELM-EHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSL 369
Query: 757 EREKEALGQ---QERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRA 813
E + Q Q+ ++A + L + + A+Q RQ+L + E L QQ +
Sbjct: 370 ELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQL-AGCQEAVNLLQQQHDQWEE 428
Query: 814 ELEELRQQLE------ESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLE-LERQAW 866
E + LRQ+L+ ++ + T L+ E + +E+E Q L+QQLE LE++AW
Sbjct: 429 EGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELL-QKAREELRQQLEVLEQEAW 487
Query: 867 EAGRT-----------------RKEEAWLLNREQELREEIRKGRDKE-----IELVIHRL 904
R ++EE L RE+E +E+ G + + EL+ R
Sbjct: 488 RLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLRE 547
Query: 905 EADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLR 964
+ + + E + ++ + + E ++EL SE L+ ++L+ + N
Sbjct: 548 ALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEA 607
Query: 965 LQ----GLVRQKERALEDAQAVNEQLSS--ERSNLAQVIRQEFEDRLAASEEETRQAKAE 1018
L GL +Q + E+ Q+V ++ + + N QV E E R A E+ +A+
Sbjct: 608 LALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQ 667
Query: 1019 L-------ATLQARQ---QLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEEL 1068
L A LQA Q E EE+ +++ + ++E A + L H+ A ++ + L
Sbjct: 668 LQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARA 727
Query: 1069 LEQ 1071
+++
Sbjct: 728 VQE 730
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 107 bits (268), Expect = 5e-23
Identities = 172/724 (23%), Positives = 313/724 (43%), Gaps = 70/724 (9%)
Query: 293 LEHLLQAKR---EEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRAL 349
LE +L+ K+ E+ R R E T L ++E A R E RQ + ++L+
Sbjct: 476 LEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLR----- 530
Query: 350 RAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAH-QALKANNTGGGLPAAGPGD 408
R+ + +T + E R+ +R +EL T T H Q++ N
Sbjct: 531 RSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK----------- 579
Query: 409 RCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK-SRGPLEELLHTLQLL 467
D Q+ + R + ++ G+ +E++ A+ S G ++ ++L
Sbjct: 580 -----EDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQV----EVL 630
Query: 468 EKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQ 527
+KE L R + + A ++ A LEK +L+ + G L E LQ
Sbjct: 631 KKE---LLRTQEELKELQAERQSQEVAGRHRDRELEK--QLAVLRVEADRGRELEEQNLQ 685
Query: 528 SIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPL-ELGSEVSTSVMRLKLEVEEKKQAMLL 586
+++ QD ++ + V EA L + + V T++ + E +E ++ +L
Sbjct: 686 ----LQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILG 741
Query: 587 LQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCE 646
L++ L + R L + +A+ +L+ + + EA Q+ ++ E++ L+
Sbjct: 742 LEQQLKETRGLV-----DGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKR 796
Query: 647 AVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVR 706
A+ A L +E QR R+ Q Q + L+E E RR K E+ K++ + TV
Sbjct: 797 ALEARL-EEAQRGLARLGQEQQTLN---RALEEEGKQREVLRRGKAELEEQKRLLDRTVD 852
Query: 707 GLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALG-- 764
L E++K+ KQ +++L++ E + + R RQA++ + E+ L
Sbjct: 853 RLNKELEKIGEDSKQALQQLQAQLE-DYKEKARREVADAQRQAKDWASEAEKTSGGLSRL 911
Query: 765 QQERERARQRFQQHLEQEQWA-----LQQQRQRLYSEVAEERERLGQQAARQRAELEE-- 817
Q E +R RQ Q + A L QR + + AE ++R ARQ LEE
Sbjct: 912 QDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKV 971
Query: 818 --LRQQLEESSSALTRALRAEFEKGREE--QERRHQMELNTLKQQLELERQAWEAGRTRK 873
L +L+E + + L +GR++ Q R M+ + +Q LE ++ + E R K
Sbjct: 972 SRLETELDEEKNTV-ELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLE--RQNK 1028
Query: 874 EEAWLLNREQELREEIRK--GRDKEIELVIHRLEADMA--LAKEESEKAAESRIKRLRDK 929
+ L + ++ + + +L+ RL+A+ + + + E ++K L +
Sbjct: 1029 DLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQ 1088
Query: 930 YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSE 989
E E + + +L R LK Q+ EAE E RL GL ++ +R +E+ VNEQL +
Sbjct: 1089 IEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQAR 1148
Query: 990 RSNL 993
+L
Sbjct: 1149 IKSL 1152
Score = 96.3 bits (238), Expect = 1e-19
Identities = 127/513 (24%), Positives = 225/513 (43%), Gaps = 61/513 (11%)
Query: 577 VEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIE 636
+E ++Q M L R L ++ + T+ + Q+ +E AT Q L + E
Sbjct: 543 LEAERQKMSALVRGLQRELEETSEETGHWQS----MFQKNKEDLRATKQELLQLRMEKEE 598
Query: 637 DKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEK 696
++ L EK E + EL+Q A+A A +++ LK+ + T++ +E +
Sbjct: 599 MEEELGEKIEVLQRELEQ---------ARASAGDTRQVEVLKKELLRTQEELKEL---QA 646
Query: 697 TKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAEL-LQSDERASQRCLRQAEELREQ 755
++ +EV R + E++K +A + E R + L E L LQ + ++ +A + +
Sbjct: 647 ERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMV 706
Query: 756 LEREKEALGQQ---------ERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQ 806
E E LGQ+ E + F++ + + L++ R + A E RL
Sbjct: 707 AEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEA-RLRD 765
Query: 807 QAARQRAELEELRQQL------EESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLE 860
+ R AE ++L + L E S +A RAL A E+ + R Q E TL + LE
Sbjct: 766 KLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQ-EQQTLNRALE 824
Query: 861 LERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAE 920
E G+ R+ +L R + EE ++ D+ ++ RL ++ E+S++A +
Sbjct: 825 ------EEGKQRE----VLRRGKAELEEQKRLLDRTVD----RLNKELEKIGEDSKQALQ 870
Query: 921 SRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQ 980
+L D E E+ ++R+ ++ SE + + G RLQ +++ +AL+ +Q
Sbjct: 871 QLQAQLEDYKEKARREVADAQRQAKDWASEAE----KTSGGLSRLQDEIQRLRQALQASQ 926
Query: 981 AVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTA 1040
A + ++ LAQ RL E+E K +ARQ LEE R++T
Sbjct: 927 AERDTARLDKELLAQ--------RLQGLEQEAENKKRSQDD-RARQLKGLEEKVSRLETE 977
Query: 1041 LARKEEAVSSLRTQHEAAVKRADHLEELLEQHR 1073
L ++ V L + + D L L Q R
Sbjct: 978 LDEEKNTVELLTDRVNRGRDQVDQLRTELMQER 1010
Score = 77.4 bits (189), Expect = 7e-14
Identities = 101/435 (23%), Positives = 190/435 (43%), Gaps = 72/435 (16%)
Query: 517 DGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQE-------------GWVPEAGPGPLELG 563
DG EA+L+ + L+ ++ ++ L++ QE + EA G LG
Sbjct: 754 DGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLG 813
Query: 564 SEVSTSVMRLKLEVEEKKQAMLLLQRA-LAQQRDLTARRVKETEKALSR----------Q 612
E T + LE E K++ +L +A L +Q+ L R V K L + Q
Sbjct: 814 QEQQT--LNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQ 871
Query: 613 LQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQH-- 670
LQ Q E Y+ +R +A + +D +EK ++ L+ E QR + + +QA+
Sbjct: 872 LQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDT 931
Query: 671 -----ELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQK----------L 715
EL ++L+ L E +R + + K E V LE E+ +
Sbjct: 932 ARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDR 991
Query: 716 IARHKQEVRRLKSLHEAELLQSDERASQRCL--------RQAEELREQL------EREKE 761
+ R + +V +L++ EL+Q ER++++ L RQ ++L+ +L ++
Sbjct: 992 VNRGRDQVDQLRT----ELMQ--ERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSA 1045
Query: 762 ALGQ--------QERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRA 813
+L Q QER +A +R + L+ L+++ + L ++ +ER+ + Q +
Sbjct: 1046 SLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSL 1105
Query: 814 ELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRK 873
++ L++Q++E+ + R L +K + E E +H++ + LE+ +W
Sbjct: 1106 RVKALKRQVDEAEEEIER-LDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSA 1164
Query: 874 EEAWLLNREQELREE 888
E+ L N EE
Sbjct: 1165 AESALKNEGLSSDEE 1179
Score = 46.2 bits (108), Expect = 2e-04
Identities = 67/336 (19%), Positives = 131/336 (38%), Gaps = 43/336 (12%)
Query: 763 LGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQ-------------AA 809
LG Q R R +R + +++ + RL + EERER +
Sbjct: 189 LGGQARGRTGRRTRMLPPEQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTKYDNHVGTS 248
Query: 810 RQRAELEELRQQLEESSSALTRA-LRAEFEKGREEQERRHQMELNTLKQQLELERQAWEA 868
+Q A+ + L S S T+ + FE+ R + ++ + L +++A
Sbjct: 249 KQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQEAAPP 308
Query: 869 GRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLE----------------ADMALAK 912
G +A + +E E +++ LV+ +++ ++
Sbjct: 309 GSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKV 368
Query: 913 EESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQL----GEAEGENLRLQGL 968
EE ++ + +K+ R K E LE+ + E CS L+ L GEA+ N LQ +
Sbjct: 369 EELQRKLDEEVKK-RQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNM 427
Query: 969 VRQKERALEDAQAVNEQLSSERSNLAQVIRQE------FEDRLAASE--EETRQAKAELA 1020
R ++ + + Q+ ++ L V E +D L E EE + K +
Sbjct: 428 KRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVE 487
Query: 1021 TLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHE 1056
++ EL + +K +A +++ V +R Q++
Sbjct: 488 EQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQ 523
Score = 43.9 bits (102), Expect = 8e-04
Identities = 58/296 (19%), Positives = 127/296 (42%), Gaps = 19/296 (6%)
Query: 785 ALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQ 844
++ + +Y + E R+ + + E Q L SS T+A+ + E R+ +
Sbjct: 310 SVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVE 369
Query: 845 ERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRL 904
E + +++ K+Q +LE R +E+ +R QEL E RKG ++ + +
Sbjct: 370 ELQRKLDEEVKKRQ-KLEPSQVGLERQLEEKTEECSRLQELLER-RKGEAQQSNKELQNM 427
Query: 905 EADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLR 964
+ + E+ E+++ L++K + + E ++ L + E + L E R
Sbjct: 428 KRLLDQG-EDLRHGLETQVMELQNKLK-HVQGPEPAKEVLLKDLLETRELLEEVLEGKQR 485
Query: 965 LQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQA 1024
++ +R +ER L + ++ + R + +RQ++ + +T Q + + A
Sbjct: 486 VEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQY-------QRDTEQLRRSMQ--DA 536
Query: 1025 RQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1080
Q + E R+ +AL R L+ + E + H + + ++++ +TK
Sbjct: 537 TQDHAVLEAERQKMSALVR------GLQRELEETSEETGHWQSMFQKNKEDLRATK 586
Score = 40.8 bits (94), Expect = 0.007
Identities = 93/495 (18%), Positives = 182/495 (36%), Gaps = 82/495 (16%)
Query: 234 SSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVT---------IQRWYRHQVQ 284
+ AT + T L +E +E R + Q T ++ R ++Q
Sbjct: 709 AEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQ 768
Query: 285 RRGAGAARLEHLLQAKREEQ------------RQRSGEGTLLDLHQQKEAARRKAREE-K 331
R A +LE L A +EE+ R + L L Q+++ R EE K
Sbjct: 769 RLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGK 828
Query: 332 ARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQ----------ELS 381
R+ R EL++++ L + + + +++ + AQ E++
Sbjct: 829 QREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVA 888
Query: 382 PTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNL 441
A +A T GGL + L + + + ++ +++LAQ G
Sbjct: 889 DAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQ 948
Query: 442 EMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADN 501
E R L+ L + LE E D EE + L D
Sbjct: 949 EAENKKRSQDDRARQLKGLEEKVSRLETELD-----------------EEKNTVELLTDR 991
Query: 502 L----EKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGP 557
+ ++ +L E ++ + + + I L+ K + +L S + P A
Sbjct: 992 VNRGRDQVDQLRT--ELMQERSARQDLECDKIS--LERQNKDLKTRLASSEGFQKPSASL 1047
Query: 558 GPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQR 617
LE ++ +++ +L+ EE+++ +L T R+++ K LS Q++ +R
Sbjct: 1048 SQLESQNQ----LLQERLQAEEREKTVL----------QSTNRKLERKVKELSIQIEDER 1093
Query: 618 EHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKL 677
+H DQL K L + + E+++ D + + + QHE+
Sbjct: 1094 QHVNDQ-------KDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVN---- 1142
Query: 678 KELMSATEKARREKW 692
++L + + ++ W
Sbjct: 1143 EQLQARIKSLEKDSW 1157
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 107 bits (267), Expect = 6e-23
Identities = 137/588 (23%), Positives = 262/588 (44%), Gaps = 114/588 (19%)
Query: 575 LEVEEKKQAMLLLQRALAQQRD--LTARRVKETEKALSRQLQRQREHYEATIQRHLAFID 632
L+V +++ M+ + L + R+ L A + L QL ++ + +Q
Sbjct: 838 LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897
Query: 633 Q-------LIEDKKVLSEKCEAVVAELKQEDQRC----TERVAQAQAQHELEIKKLKELM 681
+ L K+ L E C + A +++E++RC E+ Q ELE ++L+E
Sbjct: 898 EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELE-EQLEEEE 956
Query: 682 SATEKARREKWISE-KTKKIKEVTV-------------RGLEPEIQKLIARHKQEVRRLK 727
SA +K + EK +E K KK++E + + LE I + +E + K
Sbjct: 957 SARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSK 1016
Query: 728 SL------HEAELLQSDERASQRCLRQAEELREQLEREKEAL------------------ 763
SL HEA + +ER LR+ E+ R++LE+ + L
Sbjct: 1017 SLAKLKNKHEAMITDLEER-----LRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 764 ---------GQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERL-GQQAARQRA 813
++E + A R ++ Q+ AL++ R+ L S+++E +E L ++A+R +A
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE-LESQISELQEDLESERASRNKA 1130
Query: 814 ---------ELEELRQQLEES--SSALTRALRAEFE-------KGREEQERRHQMELNTL 855
ELE L+ +LE++ S+A + LR++ E K EE+ + H+ ++ +
Sbjct: 1131 EKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEM 1190
Query: 856 KQQ--LELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKE 913
+Q+ +E A + +T++ +A L +Q L E R E+++++ + D E
Sbjct: 1191 RQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE-RGELANEVKVLLQG-KGD----SE 1244
Query: 914 ESEKAAESRIKRLRDKY---EAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVR 970
K E++++ L+ K+ E +EL KLQ + G L +++ ++ +L
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304
Query: 971 QKERALEDAQAVNEQLSSERSNLAQVIRQ------EFEDRLAASEEETRQAKAELATLQA 1024
E L+D Q + ++ + ++ +L+ ++Q F ++L EE + ++ATL
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL-- 1362
Query: 1025 RQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQH 1072
H +V + E++V L T E K LE L ++H
Sbjct: 1363 ---------HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRH 1401
Score = 101 bits (252), Expect = 3e-21
Identities = 153/660 (23%), Positives = 292/660 (44%), Gaps = 127/660 (19%)
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
L A E E+ +A+ + + + E+E+ +++ ++Q+ L+L +V+
Sbjct: 920 LEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK----------LQL-EKVT 968
Query: 568 TSVMRLKLEVE----EKKQAMLLLQRALAQQR--DLTARRVKETEKALS----------- 610
T KLE E E + L ++ L + R + T +E EK+ S
Sbjct: 969 TEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM 1028
Query: 611 --------RQLQRQREHYEATIQR----HLAFIDQLIEDKKVLSEKCEAVVAELKQEDQR 658
R+ ++QR+ E T ++ DQ+ E + ++E + +A+ ++E Q
Sbjct: 1029 ITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE-LKMQLAKKEEELQA 1087
Query: 659 CTERVAQAQAQHELEIKKLKELMS---------ATEKARREKWISEKTKKIKEVTVRGLE 709
RV + AQ + +KK++EL S +E+A R K +EK K+ + L+
Sbjct: 1088 ALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNK--AEKQKRDLGEELEALK 1145
Query: 710 PEI----------QKLIARHKQEVRRLK-------SLHEAELLQSDERASQRC------L 746
E+ Q+L ++ +QEV LK HEA++ + ++ SQ L
Sbjct: 1146 TELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQL 1205
Query: 747 RQAEELREQLEREKEALGQQERERARQ--------RFQQHLEQEQWALQQQRQRLYSEVA 798
Q + ++ LE+ K+ L + E A + +H ++ A Q+ Q ++E
Sbjct: 1206 EQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGE 1265
Query: 799 EERERLGQQAARQRAELEE---LRQQLEESSSALTR---ALRAEFEKGRE--EQERRHQM 850
R L + + + EL+ L Q + SS LT+ AL ++ + +E ++E R ++
Sbjct: 1266 RVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKL 1325
Query: 851 ELNTLKQQLELERQAWEAGRTRKEEAWLLNREQ-ELREEIRKGRDKEIELVIHRLEADMA 909
L+T +Q+E E+ ++ REQ E EE + +K+I +H ADM
Sbjct: 1326 SLSTKLKQVEDEKNSF--------------REQLEEEEEAKHNLEKQI-ATLHAQVADMK 1370
Query: 910 LAKEES----EKAAESRIKRLRD------KYE---AELSELEQSERKLQERCSELKGQLG 956
E+S E A E + K +D ++E A +LE+++ +LQ+ +L L
Sbjct: 1371 KKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLD 1430
Query: 957 EAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDR---LAASEEETR 1013
L+ ++ ++ L + + ++ + + ER A+ +E E + LA + EE
Sbjct: 1431 HQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDR-AEAEAREKETKALSLARALEEAM 1489
Query: 1014 QAKAELATLQARQQLELEEVHRR---VKTALARKEEAVSSLRTQHEAAVKRADHLEELLE 1070
+ KAEL L + + E+E++ V ++ E++ +L Q E + + LE+ L+
Sbjct: 1490 EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ 1549
Score = 99.4 bits (246), Expect = 2e-20
Identities = 173/867 (19%), Positives = 360/867 (41%), Gaps = 141/867 (16%)
Query: 292 RLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRA 351
+++ LLQ R+E+ + E L+ + +++ AA + E + Q++ A ++LQ + L+A
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMA-EKLQLQEQLQA 891
Query: 352 QKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCL 411
+ AE R+ +Q +E+ + +RC
Sbjct: 892 ETELCAEA----EELRARLTAKKQELEEICHDLEARVEEE---------------EERCQ 932
Query: 412 PTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ QQ ++ + + +++A L++ + L++L +LE +
Sbjct: 933 HLQAEKKKMQQNIQELEEQLEEEESARQKLQLE-----KVTTEAKLKKLEEEQIILEDQN 987
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
L + + R A + ++LT + EK L+ E E +L+
Sbjct: 988 CKLAKEKKLLEDRIA-----EFTTNLTEEE-EKSKSLAKLKNKHEAMITDLEERLRREEK 1041
Query: 532 FLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRAL 591
E+EK+ + + EG + EL ++++ M+L + EE+ QA L
Sbjct: 1042 QRQELEKTRR-----KLEGDSTDLSDQIAELQAQIAELKMQLAKK-EEELQAALARVEEE 1095
Query: 592 AQQRDLTARRVKETEKALS---------RQLQRQREHYEATIQRHLAFIDQLIED----- 637
A Q+++ ++++E E +S R + + E + + L + +ED
Sbjct: 1096 AAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST 1155
Query: 638 -----------------KKVLSEKC---EAVVAELKQEDQRCTERVAQAQAQHELEIKKL 677
KK L E+ EA + E++Q+ + E +A+ Q + L
Sbjct: 1156 AAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215
Query: 678 KELMSATEKARRE-----------KWISEKTKK-----IKEVTVRGLEPEIQKLIARHKQ 721
++ E R E K SE +K ++E+ V+ E E + K
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275
Query: 722 EVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERA---------- 771
+++ + LL + S + + L QL+ +E L ++ R++
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVE 1335
Query: 772 --RQRFQQHLEQEQWA---LQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESS 826
+ F++ LE+E+ A L++Q L+++VA+ ++++ + + EE++++L++
Sbjct: 1336 DEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKM-EDSVGCLETAEEVKRKLQKDL 1394
Query: 827 SALTRALR---AEFEKGREEQERRHQMELNTLKQQLELERQ-AWEAGRTRKEEAWLLNRE 882
L++ A ++K E+ + R Q EL+ L L+ +RQ A + +K+ LL E
Sbjct: 1395 EGLSQRHEEKVAAYDK-LEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE 1453
Query: 883 QELREEIRKGRDKEIELVIHRLEADMALAKE-ESEKAAESRIKRLRDKYEAELS------ 935
+ + + + RD+ + ++LA+ E ++ ++RL ++ E+
Sbjct: 1454 KTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSK 1513
Query: 936 --------ELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS 987
ELE+S+R L+++ E+K QL E E E +A EDA+ E
Sbjct: 1514 DDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL-----------QATEDAKLRLEV-- 1560
Query: 988 SERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEA 1047
NL Q ++ +FE L +E++ + K +L + ELE+ ++ A+A +++
Sbjct: 1561 ----NL-QAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL 1615
Query: 1048 VSSLRTQHEAAVKRADHLEELLEQHRR 1074
L+ + +E ++Q R+
Sbjct: 1616 EMDLKDLEAHIDSANKNRDEAIKQLRK 1642
Score = 94.4 bits (233), Expect = 5e-19
Identities = 109/458 (23%), Positives = 212/458 (46%), Gaps = 52/458 (11%)
Query: 571 MRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAF 630
M K E+E + L +D + V E EK+ R L++Q E + ++ L
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKS-KRALEQQVEEMKTQLEE-LED 1546
Query: 631 IDQLIEDKKV-LSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARR 689
Q ED K+ L +A+ A+ +++ Q E Q++ + + +++++E+ + E R+
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFERDLQGRDE---QSEEKKKQLVRQVREMEAELEDERK 1603
Query: 690 EKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQ-----SDERAS-Q 743
++ ++ +K E+ ++ LE I + +++L+ L +A++ D RAS +
Sbjct: 1604 QRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL-QAQMKDCMRELDDTRASRE 1662
Query: 744 RCLRQAEELREQLER-EKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERE 802
L QA+E ++L+ E E + QE A +R ++ +QE R L E+A
Sbjct: 1663 EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQE-------RDELADEIANSSG 1715
Query: 803 RLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREE----QERRHQMELNTLKQQ 858
+ G A ++ LE QLEE E E+G E + ++ ++++ +
Sbjct: 1716 K-GALALEEKRRLEARIAQLEEE---------LEEEQGNTELINDRLKKANLQIDQINTD 1765
Query: 859 LELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDK-EIELVIHRLEADMALAKEESE- 916
L LER + +++ N+E +++ + +G K + + I LEA +A +E+ +
Sbjct: 1766 LNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDN 1825
Query: 917 -----KAAESRIKRLRDKYEAELSELEQSERKLQE----------RCSELKGQLGEAEGE 961
+AA +++R K + L +++ R ++ R +LK QL EAE E
Sbjct: 1826 ETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEE 1885
Query: 962 NLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQ 999
R R+ +R LEDA + ++ E S+L +R+
Sbjct: 1886 AQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
Score = 91.7 bits (226), Expect = 3e-18
Identities = 132/568 (23%), Positives = 248/568 (43%), Gaps = 102/568 (17%)
Query: 561 ELGSEVSTSVMRLKLEVEEKKQAMLLLQRA---LAQQRDLTARRVKETEKALSRQLQRQR 617
E+ + S +V L ++E+ K+ L++A L +R A VK + + +R
Sbjct: 1189 EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDS-EHKR 1247
Query: 618 EHYEATIQR-HLAFID------QLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQH 670
+ EA +Q + F + +L + L + + V L Q D + ++ A
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL- 1306
Query: 671 ELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLH 730
E +++ +EL+ E+ R++ +S K K++++ E ++ A+H E +++ +LH
Sbjct: 1307 ESQLQDTQELLQ--EENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE-KQIATLH 1363
Query: 731 -EAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERA---------RQRFQQHLE 780
+ ++ S CL AEE++ +L+++ E L Q+ E+ + R QQ L+
Sbjct: 1364 AQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELD 1423
Query: 781 QEQWALQQQRQR--------------------LYSEVAEERERLG--------------- 805
L QRQ + ++ AEER+R
Sbjct: 1424 DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLAR 1483
Query: 806 --QQAARQRAELEELRQQ-------LEESSSALTRALRAEFEKGREEQERRHQMELNTLK 856
++A Q+AELE L +Q L S + +++ E EK + E++ + E+ T
Sbjct: 1484 ALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVH-ELEKSKRALEQQVE-EMKTQL 1541
Query: 857 QQLELERQAWEAGRTRKE---EAWLLNREQELREEIRKGRDKEIELV--IHRLEADMALA 911
++LE E QA E + R E +A E++L+ + +K+ +LV + +EA++
Sbjct: 1542 EELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL--- 1598
Query: 912 KEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQ 971
E E+ S R K E +L +LE + E QL +LQ ++
Sbjct: 1599 --EDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR-------KLQAQMKD 1649
Query: 972 KERALEDAQAVNEQLSSERSNLAQVIRQ------EFEDRLAASEEETRQAKA-------E 1018
R L+D +A E++ ++ + ++ + ++ LAA+E RQA+ E
Sbjct: 1650 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADE 1709
Query: 1019 LATLQARQQLELEEVHRRVKTALARKEE 1046
+A + L LEE RR++ +A+ EE
Sbjct: 1710 IANSSGKGALALEE-KRRLEARIAQLEE 1736
Score = 90.1 bits (222), Expect = 1e-17
Identities = 113/443 (25%), Positives = 208/443 (46%), Gaps = 58/443 (13%)
Query: 662 RVAQAQAQHELE-IKKLKELMSATEKARREKW--ISEKTKKIKEVTVRGLEPEIQKLIAR 718
R A A+ Q +L +K L+ +A K R +W + K K + +V+ + ++++A+
Sbjct: 796 RKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVS-----RQEEEMMAK 850
Query: 719 HKQEVR-RLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQ 777
++ V+ R K L L E + + + +L+EQL+ E E + E RAR
Sbjct: 851 EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRAR----- 905
Query: 778 HLEQEQWALQQQRQRLYSEVAEERER---LGQQAARQRAELEELRQQLEESSSALTRALR 834
L ++ L++ L + V EE ER L + + + ++EL +QLEE SA +
Sbjct: 906 -LTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA---RQK 961
Query: 835 AEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRK-------EEAWLLNREQELRE 887
+ EK E + + E +Q+ LE Q + + +K E L E+E +
Sbjct: 962 LQLEKVTTEAKLKKLEE-----EQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSK 1016
Query: 888 EIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQER 947
+ K ++K E +I LE L +EE ++ +++ R K E + ++L +LQ +
Sbjct: 1017 SLAKLKNKH-EAMITDLEE--RLRREEKQR---QELEKTRRKLEGDSTDLSDQIAELQAQ 1070
Query: 948 CSELKGQLGEAEGE----NLRLQGLVRQKERALEDAQAVNEQLS-------SERS--NLA 994
+ELK QL + E E R++ QK AL+ + + Q+S SER+ N A
Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKA 1130
Query: 995 QVIRQEFEDRLAASE---EETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSL 1051
+ +++ + L A + E+T + A L+++++ E+ + + ++ E + +
Sbjct: 1131 EKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEM 1190
Query: 1052 RTQHEAAVKRADHLEELLEQHRR 1074
R +H AV + L E LEQ +R
Sbjct: 1191 RQKHSQAV---EELAEQLEQTKR 1210
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 106 bits (265), Expect = 1e-22
Identities = 121/545 (22%), Positives = 257/545 (47%), Gaps = 66/545 (12%)
Query: 438 GDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSL 497
G+ ++++ S K G LE+ L + +K+ D T R S E +++
Sbjct: 219 GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDAL---SLELYRNTI 275
Query: 498 TADNL-EKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAG 556
T + L EK KL E L+ K + ++ + K + +L Q+ EA
Sbjct: 276 TDEELKEKNAKLQ------EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD 329
Query: 557 PGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTAR---RVKETEKALSRQL 613
LG E+ + +L+ +VEE + L R QQ + R +++E E+ + Q
Sbjct: 330 ----HLGKELQSVSAKLQAQVEENE----LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE 381
Query: 614 QRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAV--VAELKQEDQRCTERVAQAQAQHE 671
++ RE E ++ +++ ++++ EK E + E+ E + R + + E
Sbjct: 382 EKIREQEEKIREQE----EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 437
Query: 672 LEIKKLKELMSATEKARREKWISEKTKKIKEVTVRG------------LEPEIQKLIARH 719
+I++L+E M EK R ++ ++ +KI+E R + + +K+ +
Sbjct: 438 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 497
Query: 720 KQEVRRLKSLHEAELLQSDERASQR--CLRQAEELREQLE--REKEALGQQERERARQRF 775
++ R+ + +HE E ++ +E+ ++ RQ E++REQ E R+KE + +QE + +Q
Sbjct: 498 EKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQ-- 555
Query: 776 QQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRA 835
E++ W +++ ++ E+ E++ +Q + R + E++R+Q E+ +R
Sbjct: 556 ----EEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEK--------IRE 603
Query: 836 EFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDK 895
+ E +E++E+ + E +Q+ +++ Q + R++E + +E+++RE+ K R++
Sbjct: 604 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQE---EKMRRQEEKIREQEKKIREQEEKIREQ 660
Query: 896 EIELVIHRLEA-----DMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSE 950
E E++ + E + +EE + E +++R +K + L Q E K+QE
Sbjct: 661 E-EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEH 719
Query: 951 LKGQL 955
L+ +
Sbjct: 720 LEAAI 724
Score = 97.4 bits (241), Expect = 6e-20
Identities = 136/647 (21%), Positives = 293/647 (45%), Gaps = 67/647 (10%)
Query: 362 PENPRETRVPGMRQPAQELS-------PTPGGTAHQALKANNTGGGLPAAGPGDRCLPTS 414
P +ETR + + ++L+ P+ G A K G P C
Sbjct: 110 PMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGC---- 165
Query: 415 DSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVL 474
SPE +Q + Q+ L ++ + + + + L H ++ LE E L
Sbjct: 166 -HSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDL 224
Query: 475 PRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLD 534
R H ++A E + A S A +K + E ++ LS ++ ++ D
Sbjct: 225 IS-RLHDSWKFA--GELEQALSAVATQKKKADRY--IEELTKERDALSLELYRNTIT--D 277
Query: 535 EMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQ 594
E K +L + + E SE+ +V LK ++E K +LL Q+ L +
Sbjct: 278 EELKEKNAKLQEKLQLVESEK--------SEIQLNVKELKRKLERAK--LLLPQQQLQAE 327
Query: 595 RDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQ 654
D + ++ L Q++ + E + Q+ + + E + EK + ++++
Sbjct: 328 ADHLGKELQSVSAKLQAQVE-ENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 386
Query: 655 EDQRCTERVAQAQAQHEL------EIKKLKELMSATEKA--RREKWISEKTKKIKEVTVR 706
++++ E+ + + Q E+ ++++ +E+M E+ R+E+ + EK +KI+E+ +
Sbjct: 387 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 446
Query: 707 GLEPEIQKLIARHKQEVRRLKSLHEAELLQSDE----RASQRCLRQAEELREQLE---RE 759
E Q+ I +++ + + + E E Q E R ++ Q E++REQ E R+
Sbjct: 447 MHE---QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQ 503
Query: 760 KEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELR 819
+E + +QE+ R ++ Q EQE+ Q+++ R E+ ++E++ +Q + R + E++
Sbjct: 504 EEKIHEQEKIREEEKRQ---EQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMW 560
Query: 820 QQLEESSSALTRALRAEF------EKGREEQERRHQMELNTLKQQLELERQAWEAGRTRK 873
+Q E+ + E EK RE++E+ + E +++Q E+ ++ E + +
Sbjct: 561 RQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQE-EKIREQEEMTQEQEE--KMGE 617
Query: 874 EEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAE 933
+E + +E++++E+ K R +E ++ R + +EE + E ++ +K +
Sbjct: 618 QEEKMCEQEEKMQEQEEKMRRQEEKI---REQEKKIREQEEKIREQEEMMQEQEEKMWEQ 674
Query: 934 LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQ 980
++ + E K+QE+ +++ Q + + +RL RQ+E +++ Q
Sbjct: 675 EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL----RQQEEKMQEHQ 717
Score = 90.5 bits (223), Expect = 8e-18
Identities = 112/538 (20%), Positives = 244/538 (45%), Gaps = 62/538 (11%)
Query: 561 ELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQ----QRDLTARR------VKETEKALS 610
EL ++V T + L + E + A+ Q A+ Q RDL +R E E+ALS
Sbjct: 185 ELEAQVHT-IRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALS 243
Query: 611 RQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKC---EAVVAELKQEDQRCTER---VA 664
++++ +I++L +++ LS + ELK+++ + E+ V
Sbjct: 244 AVATQKKKADR--------YIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVE 295
Query: 665 QAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVR 724
+++ +L +K+LK K R K + + + E G E+Q + A+ + +V
Sbjct: 296 SEKSEIQLNVKELKR------KLERAKLLLPQQQLQAEADHLG--KELQSVSAKLQAQVE 347
Query: 725 RLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQW 784
+ + L Q E R + +E E+++ ++E + +QE + Q + ++E
Sbjct: 348 ENELWNR--LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM 405
Query: 785 ALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGRE-- 842
++++ R E+ E+E ++ E EE ++LEE + +R + EK +E
Sbjct: 406 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK-IREQEEKRQEEE 464
Query: 843 ---EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIEL 899
EQE+R + E +Q+ ++ Q E R ++E+ W R++E E K R++E
Sbjct: 465 KIREQEKRQEQEAKMWRQEEKIREQE-EKIREQEEKMW---RQEEKIHEQEKIREEE--- 517
Query: 900 VIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKL---QERCSELKGQLG 956
+ + + ++E + + I R ++K + ++ + E K+ +E+ + + ++
Sbjct: 518 ---KRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIR 574
Query: 957 EAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAK 1016
E E + + RQ+E+ E + + EQ E+ + + QE E+++ EE+ + +
Sbjct: 575 EQE------EKVWRQEEKIREQEEKIREQ--EEKIREQEEMTQEQEEKMGEQEEKMCEQE 626
Query: 1017 AELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 1074
++ + + + + E++ + K ++E+ E K + E++ EQ +
Sbjct: 627 EKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 684
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 106 bits (264), Expect = 1e-22
Identities = 177/762 (23%), Positives = 315/762 (41%), Gaps = 133/762 (17%)
Query: 415 DSSPEPQQPPEDRTQDVLAQDAAGD----NLEMMAP-----SRGSAKSRGPLEELLHTLQ 465
DSS PP D D A+D G+ N E + R + RG EL+ Q
Sbjct: 108 DSSTASFDPPSD--MDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQ 165
Query: 466 LLEKEPD----VLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLL 521
+L++E +L + + R A EE +L++ + A E + +
Sbjct: 166 MLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQE--EFDASLEEKDQYISV 223
Query: 522 SEAKLQSIMSFLDEMEKSGQ---------DQLDSQQEGWVPEAGP-GPLELGSEVSTSVM 571
LQ+ +S L + ++G QL+ Q E + E P E E TSV
Sbjct: 224 ----LQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVK 279
Query: 572 RLKLEVEEKKQAMLLLQRA--LAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLA 629
L+ + K+ LL+R Q + ++AL QL + + E H+A
Sbjct: 280 TLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMA 339
Query: 630 --------------FIDQLIEDKKVLS-----------EKCEAVVAELKQEDQRCTERVA 664
I+QL +DK ++ E E +A+L+ ++ T +
Sbjct: 340 EKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGE 399
Query: 665 QAQAQHEL-------EIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEI--QKL 715
+ + Q E E++K TE+ARR K +E ++IK + E I Q+
Sbjct: 400 ELREQKEKSERAAFEELEKALSTAQKTEEARR-KLKAEMDEQIKTIEKTSEEERISLQQE 458
Query: 716 IARHKQEV------------RRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEAL 763
++R KQEV +L+ LHE EL + ++ +++ + E +EQ+ K AL
Sbjct: 459 LSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQM---KVAL 515
Query: 764 GQQERERARQRFQQHLEQEQWALQQ---QRQRLYSEVAEERERLGQQAARQRAELEELRQ 820
+ + E + Q+ +QE AL++ Q++ + +E + L Q+A R + EL
Sbjct: 516 EKSQSEYLKIS-QEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELES 574
Query: 821 QLEES-----SSALTRALRAEFEKGREEQE-----RRHQMELNT---------------L 855
LE+S + + A+ E EK + +E +H+ EL + L
Sbjct: 575 SLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVL 634
Query: 856 KQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEES 915
KQQ + E + +++E L ++E + I + +K +E + D+ + ES
Sbjct: 635 KQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLE------KLDVKQTELES 688
Query: 916 EKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRL--------QG 967
+ S + + R K E ELS L+ K+++ EL+ ++ E + + + +
Sbjct: 689 LSSELSEVLKARHKLEEELSVLKDQTDKMKQ---ELEAKMDEQKNHHQQQVDSIIKEHEV 745
Query: 968 LVRQKERALEDAQAVNEQLSSERSNLA---QVIRQEFEDRLAASEEETRQAKAELATLQA 1024
+++ E+AL+D E L ER Q + E + SE E +QA A+L Q+
Sbjct: 746 SIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQS 805
Query: 1025 RQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLE 1066
Q E+ + + LA+ ++ + L T+ K+ +E
Sbjct: 806 YQSATHEQT-KAYEEQLAQLQQKLLDLETERILLTKQVAEVE 846
Score = 100 bits (250), Expect = 6e-21
Identities = 140/582 (24%), Positives = 257/582 (44%), Gaps = 86/582 (14%)
Query: 564 SEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQR---EHY 620
SE+ T+ L+ EKK+ LQ L+Q +D + RR+ E + L Q ++ E +
Sbjct: 158 SELVTAYQMLQ---REKKK----LQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEF 210
Query: 621 EATIQRHLAFIDQLIEDKKVLSEKCEA------VVAELKQEDQRCTERVAQAQAQHELEI 674
+A+++ +I L +L ++ V+ L Q + + + + + E
Sbjct: 211 DASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEP 270
Query: 675 -----KKLKELMSATEKARREKWISEKTKKI-----KEVTVRGLEPE-IQKLIARHKQEV 723
+K L + ++ +R++ + ++ K+ ++ T+ E E +Q+ + QE+
Sbjct: 271 VVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQEL 330
Query: 724 RRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQ 783
++K LH AE + + LR A+ L EQLE++K G E RQ + LE ++
Sbjct: 331 EKIKDLHMAEKTKLITQ-----LRDAKNLIEQLEQDK---GMVIAETKRQ-MHETLEMKE 381
Query: 784 WALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLE--ESSSALTRALRAEF---- 837
+ Q R R+ + E Q+ +RA EEL + L + + R L+AE
Sbjct: 382 EEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQI 441
Query: 838 ---EKGREEQERRHQMELNTLKQ------------QLELERQAWEAGRTRKEEAW---LL 879
EK EE+ Q EL+ +KQ Q+ ++ E RKE+ L
Sbjct: 442 KTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQ 501
Query: 880 NREQELREEIRKGRDK---EIELVIHRLEADMALAKEESE-------KAAESRIKRLRDK 929
RE+E +E+++ +K E + E +LA EE E +E++++ L+ +
Sbjct: 502 TREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQE 561
Query: 930 ---YEAELSELEQS-ERKLQERCSELKGQLGEAEGE----NLRLQGLVRQKERALEDAQA 981
Y + ELE S E+ LQE ++ K E E N + +V + + LE +
Sbjct: 562 AETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKH 621
Query: 982 VNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ---QLELEEVHRRVK 1038
+ L +E+ QV++Q+++ + E+ Q K L L+ ++ Q +EE++ +
Sbjct: 622 QQDALWTEK---LQVLKQQYQTEMEKLREKCEQEKETL--LKDKEIIFQAHIEEMNEKTL 676
Query: 1039 TALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1080
L K+ + SL ++ +K LEE L + T K
Sbjct: 677 EKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718
Score = 96.3 bits (238), Expect = 1e-19
Identities = 146/696 (20%), Positives = 296/696 (42%), Gaps = 92/696 (13%)
Query: 432 LAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRG-------- 483
L Q+ + E++ + S++ + + LH +L KE ++ + +T R
Sbjct: 455 LQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVA 514
Query: 484 ---------RYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLD 534
+ + E+ ++ +L L+K L+ D +E I+
Sbjct: 515 LEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELES 574
Query: 535 EMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQ 594
+EKS Q+ +Q + + E++ V + K E+E K QQ
Sbjct: 575 SLEKSLQEN-KNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKH----------QQ 623
Query: 595 RDLTARRVKETEKALSRQLQRQREHYEATIQ-----RHLAFIDQLIEDKKVLSEKCEAVV 649
L +++ ++ ++++ RE E + + + F + E + EK +
Sbjct: 624 DALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQ 683
Query: 650 AELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARRE---KWISEKTKKIKEV--- 703
EL+ +E + +A+H+LE ++L L T+K ++E K +K ++V
Sbjct: 684 TELESLSSELSEVL---KARHKLE-EELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI 739
Query: 704 ----------TVRGLEPEIQKLIARHKQEVRRLKSLHEA--ELLQSDERASQRCLRQAEE 751
T + L+ +I +L K+ + LK H+A E L++D + S+ L+QA
Sbjct: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKE-HQAHVENLEADIKRSEGELQQASA 798
Query: 752 LREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAE---ERERLGQQA 808
+ + + A +Q + Q Q L+Q+ L+ +R L +VAE +++ + +
Sbjct: 799 KLDVFQSYQSATHEQTKAYEEQLAQ--LQQKLLDLETERILLTKQVAEVEAQKKDVCTEL 856
Query: 809 ARQRAELEELRQQLEESSS-------ALTRALRAEFEKGREEQERRHQMELNTLKQQLEL 861
+ ++++L QQLE+ +S +LT+ ++ E G +EQE+ Q+ +E
Sbjct: 857 DAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQI-------LVEK 909
Query: 862 ERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES 921
E + +K+E +L ++ +E+ ++E E E M K+++++ E+
Sbjct: 910 ENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQET 969
Query: 922 RIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQA 981
K+L D+ ELE + +L ++ + N ++ + + + DA +
Sbjct: 970 LKKKLLDQEAKLKKELENTALELSQKEKQF----------NAKMLEMAQANSAGISDAVS 1019
Query: 982 VNEQLSSER-SNLAQVIRQEFEDRLAASEEETRQAKAEL-----ATLQARQQLELEEVHR 1035
E E+ +L +V R+E D ++ E++ Q EL LQ ++Q E+ E+ +
Sbjct: 1020 RLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ-EVAELKQ 1078
Query: 1036 RVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1071
++ KEE + E VK+ L EL EQ
Sbjct: 1079 KILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQ 1114
Score = 87.8 bits (216), Expect = 5e-17
Identities = 139/677 (20%), Positives = 296/677 (43%), Gaps = 78/677 (11%)
Query: 457 LEELLHTLQLLEKEPDV-LPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPP 515
L++ ++ L+LL KE D L + H A + + L+ F ++
Sbjct: 754 LKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVF---QSYQSAT 810
Query: 516 EDGTLLSEAKLQSIMSFLDEMEKSG------QDQLDSQQEGWVPEAGPGPLELGSEVSTS 569
+ T E +L + L ++E ++++Q++ E +++ ++
Sbjct: 811 HEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQV-QDLMQQ 869
Query: 570 VMRLKLEVEEKKQAMLLLQRALAQ----QRDLTARRVKETEKALSRQLQRQREHYEATIQ 625
+ + E+E+K +++ + + + +++ T + + E E + + + Q++ E Q
Sbjct: 870 LEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQ 929
Query: 626 RHLAFIDQ---LIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMS 682
+ A D L E+ + + E + ++KQ+ + E + + E ++KK E +
Sbjct: 930 KLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELE-NT 988
Query: 683 ATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERAS 742
A E +++EK + K ++ + G+ + +L K+++ L +H EL
Sbjct: 989 ALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWE 1048
Query: 743 QRCLRQAEELREQLE---REKEALGQQERERARQRF------QQHLEQEQWALQQQRQRL 793
++ +QAEEL+E E +EKE QE +Q+ ++ + +E L+++ +
Sbjct: 1049 KKLNQQAEELQEIHEIQLQEKE----QEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQ 1104
Query: 794 YSEVAEERERLGQQAA----------RQRAELEELRQQLEESSSALTRALRAEFE-KGRE 842
+ + E +E+L Q++A + +A LE+L L +S T E K
Sbjct: 1105 DTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLA 1164
Query: 843 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE---LREEIRKGRD---KE 896
E+++R EL + + + E Q+ ++ + ++ L ++ E L EE+ D K+
Sbjct: 1165 EEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKS-LEDKSLEFKKLSEELAIQLDICCKK 1223
Query: 897 IELVIHRLEADMALAKEESEKAAESRIKRLRDK-----------------YEAELSELEQ 939
E ++ ++ A SRI + + EA+L +L +
Sbjct: 1224 TEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTE 1283
Query: 940 SERKLQERCSELKGQLGEAEGE----NLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQ 995
+ L + QL E E + ++ LV +KE AL+ +Q +SE+ +
Sbjct: 1284 EQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKE-ALQKEGGNQQQAASEKESCIT 1342
Query: 996 VIRQEFEDRLAA---SEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLR 1052
+++E + + A +EE ++ K E+++L +QL V + +L+ KE A+SSLR
Sbjct: 1343 QLKKELSENINAVTLMKEELKEKKVEISSLS--KQLTDLNVQLQNSISLSEKEAAISSLR 1400
Query: 1053 TQH-EAAVKRADHLEEL 1068
Q+ E + D +++L
Sbjct: 1401 KQYDEEKCELLDQVQDL 1417
Score = 82.4 bits (202), Expect = 2e-15
Identities = 104/454 (22%), Positives = 200/454 (44%), Gaps = 50/454 (11%)
Query: 578 EEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLI-- 635
+E+ + +Q+ ++ + R + E EK L R Q + E + + + ++LI
Sbjct: 1721 QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKL 1780
Query: 636 EDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISE 695
E + + ++++ L++E + ++ + AQH +E + K + A + +
Sbjct: 1781 EHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQH-VEKEGGKNNIQAKQNLENVFDDVQ 1839
Query: 696 KTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQ 755
KT + KE+T + LE +I++L + + R K +H E+ +E S+ QA + +
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSC----LVRQKEVHRVEM---EELTSKYEKLQALQQMDG 1892
Query: 756 LEREKEALGQQERERARQRF-QQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAE 814
+ E L + E+++ Q L A + + E+++LG++ R + +
Sbjct: 1893 RNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKD 1952
Query: 815 LEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKE 874
L LR++ ++ L+ E+++ REE+ ++ Q + LEL+ + R+
Sbjct: 1953 LRMLRKEHQQE----LEILKKEYDQEREEKIKQEQ-------EDLELKHNSTLKQLMREF 2001
Query: 875 EAWLLNREQELR----EEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKY 930
L +EQEL E I K ++ E EL+ E L K+ +EK + +KR +Y
Sbjct: 2002 NTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEK--DDDLKRTAKRY 2059
Query: 931 E----AELSELEQSERKLQERCSEL--KGQLGEAEGEN--------LRLQGLVRQKERAL 976
E A E+ R LQ + EL K Q + EN + LQ + QK +
Sbjct: 2060 EEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLI 2119
Query: 977 EDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEE 1010
D++ ++ + NL EDRL E+
Sbjct: 2120 SDSKLKEQEFREQIHNL--------EDRLKKYEK 2145
Score = 77.4 bits (189), Expect = 7e-14
Identities = 116/559 (20%), Positives = 241/559 (43%), Gaps = 78/559 (13%)
Query: 562 LGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYE 621
L SE + + LK + E+K A+ +K L Q++ + E Y+
Sbjct: 1629 LESESAAKLAELKRKAEQKIAAI---------------------KKQLLSQMEEKEEQYK 1667
Query: 622 ATIQRHLAFIDQLIEDKK----VLSEKCEAVVAELKQE--DQRCTERVAQAQAQHELEIK 675
+ HL+ ++ +++++ +L EK ++V + + R + VA Q E + +
Sbjct: 1668 KGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQ 1727
Query: 676 KLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELL 735
+ + + ++ ++EK K ++ V + E + Q RL L AE
Sbjct: 1728 GCVQKTYEEKISVLQRNLTEKEKLLQRVG-QEKEETVSSHFEMRCQYQERLIKLEHAEAK 1786
Query: 736 QSDERASQRCLRQAEELREQ-------LEREKEALGQQERERARQRFQQHLEQEQWALQQ 788
Q ++++ L+ EEL E+ + + E G + +A+Q + + Q LQ+
Sbjct: 1787 QHEDQSMIGHLQ--EELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQE 1844
Query: 789 QR---QRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAE----FEKGR 841
+ Q L ++ E L +Q R E+EEL + E+ + R + E+
Sbjct: 1845 KELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENT 1904
Query: 842 EEQERRHQMELNTLK----QQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEI 897
EE+ + H ++ L Q +LE + A R +++ + R Q+ +RK +E+
Sbjct: 1905 EEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQEL 1964
Query: 898 ELV----IHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKG 953
E++ E + +E+ E S +K+L ++ +L+ Q E++L+ E
Sbjct: 1965 EILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLA---QKEQELEMTIKETIN 2021
Query: 954 QLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEE-- 1011
+ E E E L E E+ + ++++ + +L + ++ +E+ L A EEE
Sbjct: 2022 KAQEVEAELL---------ESHQEETNQLLKKIAEKDDDLKRTAKR-YEEILDAREEEMT 2071
Query: 1012 --TRQAKAELATLQARQQLELEEVHR---------RVKTALARKEEAVSSLRTQHEAAVK 1060
R + +L LQ + Q +LE+ ++T LA+K +S + + + +
Sbjct: 2072 AKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFRE 2131
Query: 1061 RADHLEELLEQHRRPTPST 1079
+ +LE+ L+++ + +T
Sbjct: 2132 QIHNLEDRLKKYEKNVYAT 2150
Score = 73.9 bits (180), Expect = 7e-13
Identities = 124/579 (21%), Positives = 244/579 (42%), Gaps = 108/579 (18%)
Query: 565 EVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATI 624
E++ + LK E ++ + LQ L +Q+ + + E L L++ ++
Sbjct: 1089 EMNKEITWLKEEGVKQDTTLNELQEQL-KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL 1147
Query: 625 QRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE----------LEI 674
+ + +QL+E K+L+E+ + V+EL + + E ++ HE LE
Sbjct: 1148 KENTFLQEQLVE-LKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEF 1206
Query: 675 KKLKELMS-----------ATEKARREKWIS-----------------EKTKKIKEV--- 703
KKL E ++ A +A+ + I+ +T K+KE
Sbjct: 1207 KKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLI 1266
Query: 704 ---TVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREK 760
TV LE ++++L +E L + Q +E+ +Q ++ + E L EK
Sbjct: 1267 KTCTVSELEAQLRQLT----EEQNTLNISFQQATHQLEEKENQ--IKSMKADIESLVTEK 1320
Query: 761 EALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEV------AEERERLGQQAARQRAE 814
EAL ++E Q QQ +++ + Q ++ L + EE + + + +
Sbjct: 1321 EAL---QKEGGNQ--QQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQ 1375
Query: 815 LEELRQQLEESSS-----ALTRALRAEFEKGREE---QERRHQMELNTL-KQQLELERQA 865
L +L QL+ S S A +LR ++++ + E Q + +++TL K+++ Q
Sbjct: 1376 LTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQV 1435
Query: 866 --WEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRI 923
W + K W + + ++ +I+L L++ A K+E + +
Sbjct: 1436 DDW----SNKFSEWKKKAQSRFTQHQNTVKELQIQL---ELKSKEAYEKDEQINLLKEEL 1488
Query: 924 KRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAV- 982
+ +++ E+E + K++++ S L+ +L + L+ + QK +E V
Sbjct: 1489 DQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVL 1548
Query: 983 ---NEQLSSERSNLAQVIR-------------QEFEDRLAASEEETRQAKAELATLQARQ 1026
N+Q E L Q ++ +E E+++ E + KAEL T +
Sbjct: 1549 KNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET----K 1604
Query: 1027 QLELEEVHRRVKTALARKEEAVSSL--RTQHEAAVKRAD 1063
+ ELE V+ VK+ KEE + +L R + E+A K A+
Sbjct: 1605 KKELEHVNLSVKS----KEEELKALEDRLESESAAKLAE 1639
Score = 63.9 bits (154), Expect = 8e-10
Identities = 108/529 (20%), Positives = 219/529 (41%), Gaps = 59/529 (11%)
Query: 579 EKKQAMLLLQ--RALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIE 636
E K+ + LQ + L +++D RVKE E+ + T++ + + +E
Sbjct: 1558 EHKELVQKLQHFQELGEEKD---NRVKEAEEKI------------LTLENQVYSMKAELE 1602
Query: 637 DKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEK 696
KK E V ++E + +R+ A E+K+ E A K + + EK
Sbjct: 1603 TKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEK 1662
Query: 697 TKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQL 756
++ K+ T L KL R ++ + L E QS+ R + EQ
Sbjct: 1663 EEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQE 1722
Query: 757 EREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAAR----QR 812
E + + Q+ E Q++L +++ LQ+ Q V+ E Q R +
Sbjct: 1723 EADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEH 1782
Query: 813 AELEE---------LRQQLEESSS--ALTRALRAEFEKGREEQERRHQME-----LNTLK 856
AE ++ L+++LEE + +L A E E G+ + + +E +
Sbjct: 1783 AEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTL 1842
Query: 857 QQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIEL-VIHRLEA---DMALAK 912
Q+ EL Q E + ++ ++ L+ +++ R E+ + K +L + +++ L +
Sbjct: 1843 QEKELTCQILEQ-KIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLE 1901
Query: 913 EESEKAAESRI--KRLRDKYEAELSELE-------QSERKLQERCSELKGQLGEAEGENL 963
E +E+ ++S + +L EA+ ++LE + ++KL + L+ L E+
Sbjct: 1902 ENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ 1961
Query: 964 RLQGLVRQK--ERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELAT 1021
+ +++++ + E + E L + ++ + + +EF +LA E+E E
Sbjct: 1962 QELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETIN 2021
Query: 1022 LQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLE 1070
+ EL E H+ L +K + + + + A EE+L+
Sbjct: 2022 KAQEVEAELLESHQEETNQLLKK------IAEKDDDLKRTAKRYEEILD 2064
Score = 59.3 bits (142), Expect = 2e-08
Identities = 76/329 (23%), Positives = 140/329 (42%), Gaps = 31/329 (9%)
Query: 750 EELREQLEREKEALGQ-----QERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERL 804
E+L ++L R + +L E A Q Q+ ++ Q L Q + + +AE RE L
Sbjct: 137 EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREEL 196
Query: 805 GQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQ 864
++ EE LEE ++ L+ + +++ R M ++ LK +LE Q
Sbjct: 197 QMDQQAKKHLQEEFDASLEEKDQYIS-VLQTQVSL-LKQRLRNGPMNVDVLKPLPQLEPQ 254
Query: 865 AWEAGRTRKEEAWLLNREQELREEIRKGRD-KEIELVIHRLEADMALAKEESEKAAESRI 923
A KEE N E + + G K +E + R++ +E K + I
Sbjct: 255 AEVF---TKEE----NPESDGEPVVEDGTSVKTLETLQQRVKR-----QENLLKRCKETI 302
Query: 924 KRLRDKYEAELSELEQSERKLQERCSELKG--QLGEAEGENLRLQGLVRQKERALEDAQA 981
+ +++ SE E + +L ER EL+ L AE L Q L DA+
Sbjct: 303 QSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQ---------LRDAKN 353
Query: 982 VNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTAL 1041
+ EQL ++ + +++ + L EEE Q ++ + + + + E+ + + A
Sbjct: 354 LIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAF 413
Query: 1042 ARKEEAVSSLRTQHEAAVKRADHLEELLE 1070
E+A+S+ + EA K ++E ++
Sbjct: 414 EELEKALSTAQKTEEARRKLKAEMDEQIK 442
Score = 34.3 bits (77), Expect = 0.65
Identities = 44/234 (18%), Positives = 100/234 (42%), Gaps = 26/234 (11%)
Query: 816 EELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEE 875
++L+Q++ E L +AL R + ++ +QL+ E+G T+
Sbjct: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
Query: 876 AWLLNR--------EQELREEIRKGRDKEIELV-------IHRLEADMALAKEESEKAAE 920
L R ++E + + KE LV ++RL+ D + A + +
Sbjct: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKE-SLVRTSSRESLNRLDLDSSTASFDPPSDMD 121
Query: 921 SRIKRLRDKYEA-ELSELEQSERKLQERCSELKGQLGE-------AEGENLRLQGLVRQ- 971
S + L ++ +L Q R+++ S +G+ E + E +LQG++ Q
Sbjct: 122 SEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQS 181
Query: 972 KERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQAR 1025
++++L + E+L ++ + +++EF+ L ++ + +++ L+ R
Sbjct: 182 QDKSLRRIAELREELQMDQ-QAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQR 234
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 106 bits (264), Expect = 1e-22
Identities = 132/577 (22%), Positives = 250/577 (43%), Gaps = 94/577 (16%)
Query: 559 PLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQRE 618
PL +E + +K E ++ K L ++ A++++L + V ++ QLQ Q E
Sbjct: 841 PLLKSAETEKEMATMKEEFQKTKDE---LAKSEAKRKELEEKMVTLLKEKNDLQLQVQSE 897
Query: 619 HYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE--LEIKK 676
+QLI++K L K + V ++E++ E A+ + + E+KK
Sbjct: 898 ADSLADAEERC--EQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKK 955
Query: 677 -LKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAEL- 734
+ +L K +EK +E K + GL+ I KL +E + L+ H+ L
Sbjct: 956 DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL----SKEKKALQETHQQTLD 1011
Query: 735 -LQSDE-------RASQRCLRQAEELREQLEREKEALGQQER------------------ 768
LQ++E +A + +Q ++L LE+EK+ ER
Sbjct: 1012 DLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMD 1071
Query: 769 -ERARQRFQQHLEQEQW-------------ALQQQRQRLYSEVAEERERLGQQAARQRA- 813
E +Q+ + LE++++ A++ Q Q+ E+ E LG++ +RA
Sbjct: 1072 MENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERAS 1131
Query: 814 -------------ELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLE 860
ELEE+ ++LEE+ A + + ++ E Q+ R +E TL+ +
Sbjct: 1132 RAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAM 1191
Query: 861 LERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAE 920
+ + + E ++ Q +++++ K + + ++E D + E+ A+
Sbjct: 1192 VAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSE------LKMETDDLSSNAEAISKAK 1245
Query: 921 SRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQ 980
++++ E ++SEL+ E + Q ++L Q RLQ + R L++
Sbjct: 1246 GNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQ-------RARLQTEAGEYSRQLDEKD 1298
Query: 981 AVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQA--------RQQLELE- 1031
A+ QLS + Q Q+ E+ EEET+ A LQ+ R+Q E E
Sbjct: 1299 ALVSQLSRSK----QASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQ 1354
Query: 1032 EVHRRVKTALARKEEAVSSLRTQHEA-AVKRADHLEE 1067
E ++ AL++ V+ RT++E A++R + LEE
Sbjct: 1355 EGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEE 1391
Score = 95.9 bits (237), Expect = 2e-19
Identities = 132/556 (23%), Positives = 247/556 (44%), Gaps = 70/556 (12%)
Query: 558 GPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQR 617
G L+L E + + K +++EK L++ + +L ++ E E+A+ QLQ++
Sbjct: 1060 GDLKLAQESTMDMENDKQQLDEK------LEKKEFEISNLISKI--EDEQAVEIQLQKKI 1111
Query: 618 EHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKL 677
+ +A I+ + + IE ++ K E ++L +E + +ER+ +A +++
Sbjct: 1112 KELQARIEE----LGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELN 1167
Query: 678 KELMSATEKARR---------EKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKS 728
K+ + +K RR E ++ KK + ++ L +I L R KQ++ + KS
Sbjct: 1168 KKREAEFQKLRRDLEEATLQHEAMVAALRKKHAD-SMAELGEQIDNL-QRVKQKLEKEKS 1225
Query: 729 --LHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWAL 786
E + L S+ A + E++ LE + L +E E+ QR L ++ L
Sbjct: 1226 ELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQ--QRLINDLTAQRARL 1283
Query: 787 QQQRQRLYSEVAEERERLGQQAARQRA----ELEELRQQLEESS---SALTRALRAEF-- 837
Q + YS +E++ L Q +R + ++EEL+ QLEE + +AL AL++
Sbjct: 1284 QTEAGE-YSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHD 1342
Query: 838 -----EKGREEQERRHQMELNTLKQQLELE--RQAWEAGRTRKEEAW------LLNREQE 884
E+ EEQE + +++ K E+ R +E ++ E L R QE
Sbjct: 1343 CDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1402
Query: 885 LREEIRKGRDK--EIELVIHRLE---ADMALAKEESEKAAESRIKRLRD----------K 929
E + K +E RL+ D+ L E S A + K+ R+ K
Sbjct: 1403 AEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQK 1462
Query: 930 YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSE 989
YE +ELE S+++ + +EL E +L+ L R+ + ++ + EQ++
Sbjct: 1463 YEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEG 1522
Query: 990 RSNLAQV--IRQEFEDRLAASEEETRQAKAELATLQA---RQQLELEEVHRRVKTALARK 1044
+ ++ I+++ E + +A+A L + R QLEL +V V +A K
Sbjct: 1523 GKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEK 1582
Query: 1045 EEAVSSLRTQHEAAVK 1060
+E + L+ H V+
Sbjct: 1583 DEEIDQLKRNHTRVVE 1598
Score = 78.6 bits (192), Expect = 3e-14
Identities = 180/811 (22%), Positives = 325/811 (40%), Gaps = 94/811 (11%)
Query: 303 EQRQRSGEGTL--LDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKA-STAER 359
E+ + +G T ++L++++EA +K R R A +Q ALR + A S AE
Sbjct: 1151 ERLEEAGGATSAQVELNKKREAEFQKLR----RDLEEATLQHEAMVAALRKKHADSMAEL 1206
Query: 360 GPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPE 419
G + + + + EL + A + G L C D E
Sbjct: 1207 GEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKM-----CRSLEDQVSE 1261
Query: 420 PQQPPEDRTQ---DVLAQDA-----AGDNLEMMAP--------SRGSAKSRGPLEELLHT 463
+ E++ + D+ AQ A AG+ + SR S +EEL H
Sbjct: 1262 LKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQ 1321
Query: 464 LQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSE 523
L+ K + L R E+ + L++ A E + T
Sbjct: 1322 LEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQR-ALSKANSEVAQWRTKYET 1380
Query: 524 AKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQA 583
+Q + +K Q ++++ A LE + RL+ EVE+
Sbjct: 1381 DAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQ------RLQNEVED---L 1431
Query: 584 MLLLQRALAQQRDLTARRVKETEKALSRQLQRQRE---HYEATIQRHLAFIDQLIEDKKV 640
ML ++R+ A L ++ + +K LS Q+ E EA+ + + +L + K V
Sbjct: 1432 MLDVERSNAACAALDKKQ-RNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNV 1490
Query: 641 LSEKCEAVVA------ELKQEDQRCTERVAQAQAQ-HELE-IKKLKE-----LMSATEKA 687
E + + L+QE TE++A+ Q HELE IKK E + +A E+A
Sbjct: 1491 YEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEA 1550
Query: 688 RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHE--AELLQSDERASQRC 745
E ++ + ++ E+ + IA +E+ +LK H E +QS A R
Sbjct: 1551 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRS 1610
Query: 746 LRQAEELREQLEREKEALGQQ---------ERERARQRFQQHLEQEQWALQQQRQRLYSE 796
A +++++E + + Q E R + Q L++ Q L R +
Sbjct: 1611 RNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDAL-RGQED 1669
Query: 797 VAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLK 856
+ E+ + ++A +AE+EEL LE++ + + E E + H + +
Sbjct: 1670 LKEQLAIVERRANLLQAEIEELWATLEQTERS-RKIAEQELLDASERVQLLHTQNTSLIN 1728
Query: 857 QQLELERQAWEAGRTRKEEAWLLNREQELREEIRKG-RDKEIELVIHRLEADMALAKEES 915
+ +LE + + + E ++ + E+ +K D + + E D + E
Sbjct: 1729 TKKKLEN---DVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1785
Query: 916 EKAAESRIKRLRDKY-EAELSELEQSER---KLQERCSELKGQLGEAEGENLRLQGLVRQ 971
+K E +K L+ + EAE L+ ++ KL+ R EL+G++ + N +R+
Sbjct: 1786 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRK 1845
Query: 972 KERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAA--------SEEETRQAKAELATLQ 1023
ER +++ + Q +R N+ ++ Q+ D+L A +EE Q+ A L+ +
Sbjct: 1846 HERRVKE---LTYQTEEDRKNVLRL--QDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFR 1900
Query: 1024 ARQQLELEEVHRRVKTALARKEEAVSSLRTQ 1054
+ Q ELEE R A E V+ LR +
Sbjct: 1901 -KLQHELEEAEERADIA----ESQVNKLRVK 1926
Score = 66.2 bits (160), Expect = 2e-10
Identities = 94/390 (24%), Positives = 172/390 (44%), Gaps = 56/390 (14%)
Query: 711 EIQKLIARHKQEVRRLKS-LHEAELLQSD-ERASQRCLRQAEELREQLEREKEALGQQER 768
E +K +A K+E ++ K L ++E + + E L++ +L+ Q++ E ++L E
Sbjct: 847 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAE- 905
Query: 769 ERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSA 828
ER Q + ++ E + + +E AEE E + + ++ +LE+ +L++
Sbjct: 906 ERCEQLIKNKIQLEA------KIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDD 959
Query: 829 LTRAL-RAEFEKGREEQERRHQME----LNTLKQQLELERQAWEAGRTRKEEAWLLNREQ 883
L L + E EK E + ++ E L+ +L E++A + T ++ L E+
Sbjct: 960 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQ--ETHQQTLDDLQAEE 1017
Query: 884 ELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERK 943
+ + K + K +E + LE + E EK ++R + K E +L ++S
Sbjct: 1018 DKVNILTKAKTK-LEQQVDDLEGSL-----EQEKKLRMDLERAKRKLEGDLKLAQESTMD 1071
Query: 944 LQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFED 1003
++ +L +L + E E + L+ + +ED QAV QL + L I +
Sbjct: 1072 MENDKQQLDEKLEKKEFE---ISNLISK----IEDEQAVEIQLQKKIKELQARIEE---- 1120
Query: 1004 RLAASEEETRQAKAELATLQARQQLELEEVHRRVKTA---------LARKEEA------- 1047
L E R ++A+ ++ ELEE+ R++ A L +K EA
Sbjct: 1121 -LGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRR 1179
Query: 1048 -VSSLRTQHEAAV-----KRADHLEELLEQ 1071
+ QHEA V K AD + EL EQ
Sbjct: 1180 DLEEATLQHEAMVAALRKKHADSMAELGEQ 1209
Score = 50.1 bits (118), Expect = 1e-05
Identities = 64/288 (22%), Positives = 127/288 (44%), Gaps = 45/288 (15%)
Query: 815 LEELRQQLEESSSALTRA--------LRAEFEKGREEQERRHQMELNTLKQQLELERQAW 866
LEE+R E+ + +TR +R E++K + +E ++ N ++ + ++ W
Sbjct: 776 LEEMRD--EKLAQIITRTQAVCRGFLMRVEYQKMLQRREALFCIQYN-VRAFMNVKHWPW 832
Query: 867 -----------EAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEES 915
++ T KE A + Q+ ++E+ K K EL E + L KE++
Sbjct: 833 MKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELE----EKMVTLLKEKN 888
Query: 916 EKA--AESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKE 973
+ +S L D E +L +++ +L+ + E+ + E E N L K+
Sbjct: 889 DLQLQVQSEADSLADA-EERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTA----KK 943
Query: 974 RALED-AQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQ------ARQ 1026
R LED + + + LA+V +++ A+E + + E+A L +++
Sbjct: 944 RKLEDECSELKKDIDDLELTLAKVEKEKH-----ATENKVKNLTEEMAGLDETIAKLSKE 998
Query: 1027 QLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 1074
+ L+E H++ L +E+ V+ L ++ D LE LEQ ++
Sbjct: 999 KKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKK 1046
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 106 bits (264), Expect = 1e-22
Identities = 227/912 (24%), Positives = 346/912 (37%), Gaps = 185/912 (20%)
Query: 241 RNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAK 300
R +G +R E+ EEAE + + +Q R +R A A L
Sbjct: 299 RQEAQALSGQAKRAELYREEAEALRERAGRLP-RLQEELRRCRERLQAAEAYKSQL---- 353
Query: 301 REEQRQRSG--EGTLLDLHQQKEAARRK-AREEKARQARRAAIQELQQKRA----LRAQK 353
EE+R SG E + L +Q EAAR + AR + ++ L + A LR Q
Sbjct: 354 -EEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQV 412
Query: 354 ASTAERG-------------PPENPRETRVPGMRQPAQ-ELSPTPGGTAHQALKANNTGG 399
AE PP +P E + G Q E+ G + N
Sbjct: 413 DQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELR 472
Query: 400 GLPAAGPG--------------DRCLPTSDSSPEPQQPPEDRTQDVL--AQDAAGDNLEM 443
GL G D LP + +P+ + Q ++ A+D L++
Sbjct: 473 GLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDL 532
Query: 444 MAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRP---RTHHRGRYAWASEEDDASSLTAD 500
P+ S LE Q + +P P W+ +E + T +
Sbjct: 533 APPALDSV-----LEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQE 587
Query: 501 NLEKFGKLSAFPEP----PEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWV---- 552
+ EK G+ S+ P P G K+Q+ E E Q + E W
Sbjct: 588 SPEKAGRRSSLQSPASVAPPQGP---GTKIQAPQLLGGETEGREAPQGELVPEAWGLRQE 644
Query: 553 -PEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSR 611
PE PGP E S ++LE +E L L A+ R+ +R++ T + +
Sbjct: 645 GPEHKPGPSEPSS--------VQLEEQEGPNQGLDLATGQAEAREHD-QRLEGTVRDPAW 695
Query: 612 QLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQ-H 670
Q +Q+ +Q + + + E + VAE + + + +A+A
Sbjct: 696 QKPQQKSEGALEVQ---------VWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGD 746
Query: 671 ELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLH 730
ELE + K TE AR K +++ + E H++ ++
Sbjct: 747 ELEAQARKLEAQNTEAARLSKELAQARRAEAEA---------------HREA--EAQAWE 789
Query: 731 EAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQR 790
+A L ++ E A Q L A + RE L A G++ R QW + R
Sbjct: 790 QARLREAVEAAGQE-LESASQEREALVEALAAAGRERR--------------QWEREGSR 834
Query: 791 QRLYSEVAEER----ERLGQQ----AARQRAELEELRQQLEES----------SSALTRA 832
R SE AEER E G+Q A R+R E E L+ +LE++ L R
Sbjct: 835 LRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRE 894
Query: 833 L------RAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAW--LLNREQE 884
L R EF + +E Q +R+Q L+Q+LE E Q A T KEEA L R +
Sbjct: 895 LEQAALERQEFLREKESQHQRYQ----GLEQRLEAELQ---AAATSKEEALMELKTRALQ 947
Query: 885 LREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKL 944
L EE+ + R L +K AE +L + L E+E+S L
Sbjct: 948 LEEELFQLRQGPAGL--------------GPKKRAE---PQLVETQNVRLIEVERSNAML 990
Query: 945 QERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDR 1004
+ L+GQL EG+ LQG ++ + AQ + +L +E+S L ++ QE +
Sbjct: 991 VAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVL-EIQGQELHRK 1049
Query: 1005 LAASEEETRQAKAE-----------------LATLQARQQLELEEV---HRRVKTALARK 1044
L EEE R A+ LA LQ RQ+ ELE + HR +K +
Sbjct: 1050 LEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRAL 1109
Query: 1045 EEAVSSLRTQHE 1056
E A L+ +HE
Sbjct: 1110 ELAHRELQGRHE 1121
Score = 85.5 bits (210), Expect = 2e-16
Identities = 145/594 (24%), Positives = 251/594 (42%), Gaps = 101/594 (17%)
Query: 562 LGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYE 621
LG E+ +L+ + E + L + LAQ R A +E E A + + R RE E
Sbjct: 744 LGDELEAQARKLEAQNTEAAR----LSKELAQARRAEAEAHREAE-AQAWEQARLREAVE 798
Query: 622 ATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE----LEIKKL 677
A Q ++ ++++ L E A E +Q ++ + AQ++A E LE +
Sbjct: 799 AAGQE----LESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGR 854
Query: 678 KELMSATEKARREKWISEKTKKIKEVTVRG---------LEPEIQKLIARHKQEVRRLKS 728
+ L A E+ RREK + ++++ VRG L+ E+++ ++ +R +S
Sbjct: 855 QHLEEA-ERERREKEALQA--ELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKES 911
Query: 729 LH----------EAEL---LQSDERASQRCLRQAEELRE---QLEREKEALGQQERERAR 772
H EAEL S E A +A +L E QL + LG ++R +
Sbjct: 912 QHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQ 971
Query: 773 ------------QRFQQHLEQEQWALQQQRQRLYSEVAE----------ERERLGQQAAR 810
+R L E+ ALQ Q Q L ++ + +R + ++R
Sbjct: 972 LVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSR 1031
Query: 811 QRAE---LEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWE 867
+AE LE Q+L L +RA + +EE + Q L K +L+R
Sbjct: 1032 LQAEKSVLEIQGQELHRKLEVLEEEVRAA-RQSQEETRGQQQALLRDHKALAQLQR---- 1086
Query: 868 AGRTRKEEAWLLNREQELREEIR--KGRDKEIELVIHRLEADMALAKEESEKAAESRIKR 925
R E LL R ++L+ +R + +E++ +L+A A + + R +
Sbjct: 1087 --RQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERL 1144
Query: 926 LRDKY-----EAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQ 980
++D + E EL L+ + Q +EL + GE +GE L+G + + E +
Sbjct: 1145 MQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLE 1204
Query: 981 AVNEQLSSERSNL-AQVIRQEFEDRL-----AASEEETRQAKAELATLQARQQLELEEVH 1034
++QL L R + L +A EEE RQ AE+ L +R+ EL E
Sbjct: 1205 MQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQAL-SRENRELLERS 1263
Query: 1035 RRVKTALARKE----EAVSSLRTQHEAAVKRADHLEELLEQHR----RPTPSTK 1080
+ L R++ + +++LR + + V E++++Q+R P P TK
Sbjct: 1264 LESRDHLHREQREYLDQLNALRREKQKLV------EKIMDQYRVLEPVPLPRTK 1311
Score = 73.9 bits (180), Expect = 7e-13
Identities = 161/735 (21%), Positives = 293/735 (39%), Gaps = 115/735 (15%)
Query: 315 DLHQQKEAARRKAREEKARQARRAAIQELQQKRA-------LRAQKASTAERGPPENPRE 367
D Q+ + + +E + RR+++Q ++A + E E P+
Sbjct: 573 DWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQG 632
Query: 368 TRVP---GMRQPAQELSPTPGGTAHQALKAN-------NTGGGLPAAGPGDRCLPTSDSS 417
VP G+RQ E P P + L+ + G A D+ L +
Sbjct: 633 ELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRD 692
Query: 418 P---EPQQPPEDRTQ-DVLAQDAAGDNL-----------EMMAPSRGSAKSRGP-LEELL 461
P +PQQ E + V G++L E +A R A++ G LE
Sbjct: 693 PAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQA 752
Query: 462 HTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLL 521
L+ E L + R A A E +A + L E E
Sbjct: 753 RKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLR---------EAVEAAGQE 803
Query: 522 SEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEK- 580
E+ Q + ++ + +G+++ ++EG A E +V S R LE E+
Sbjct: 804 LESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERE 863
Query: 581 ---KQAMLL-LQRALAQQRDLTARRV---KETEKA------LSRQLQRQREHY------- 620
K+A+ L++A+ + ++L AR +E E+A R+ + Q + Y
Sbjct: 864 RREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRL 923
Query: 621 EATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQ------EDQRCTERVAQAQAQHELEI 674
EA +Q ++ + + K + + E + +L+Q +R ++ + Q +E+
Sbjct: 924 EAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEV 983
Query: 675 KKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIAR-HKQEVRRLKSLHEA- 732
++ ++ A EKA + + ++ + R E +Q A+ H ++ KS+ E
Sbjct: 984 ERSNAMLVA-EKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQ 1042
Query: 733 --------ELLQSDERASQRCLRQAEELREQLEREKEALGQQERE--------------- 769
E+L+ + RA+++ + ++ L R+ +AL Q +R
Sbjct: 1043 GQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDL 1102
Query: 770 ----RARQRFQQHLEQEQWALQQQRQRLYSE---VAEERERLGQQAARQRAELEELRQQL 822
RA + + L+ LQ QR + ++ + ERERL Q RQR EELR+
Sbjct: 1103 KANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQ 1162
Query: 823 EESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELER--------QAWEAGRTRKE 874
E A E+G + ER EL +LELER Q E+ +
Sbjct: 1163 SEHDRAQMLLAELSRERGELQGERG---ELRGRLARLELERAQLEMQSQQLRESNQQLDL 1219
Query: 875 EAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESR--IKRLRDKYEA 932
A L + EL ++R +++E ++ ++A +E E++ ESR + R + +Y
Sbjct: 1220 SACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLD 1279
Query: 933 ELSELEQSERKLQER 947
+L+ L + ++KL E+
Sbjct: 1280 QLNALRREKQKLVEK 1294
Score = 51.2 bits (121), Expect = 5e-06
Identities = 83/343 (24%), Positives = 131/343 (38%), Gaps = 43/343 (12%)
Query: 705 VRGLEPEIQKLIARHKQEVRR--------LKSLHEAELLQSDERASQRCLRQ-------- 748
++GL E+Q +A QEV + L EL ++ R L
Sbjct: 160 IQGLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARE 219
Query: 749 ----AEELREQL-EREKEALGQQERERA-RQRFQQHLEQEQWALQQQRQRLYSEVAEERE 802
A+ L E L ERE L + RA + HL + + Q +RL E+ E+ E
Sbjct: 220 RDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAE 279
Query: 803 RLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELE 862
L A + E+R+ +E+ + +A RAE + E R L L+++L
Sbjct: 280 LLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRC 339
Query: 863 RQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESR 922
R+ +A K +L EE ++ LEA AL +E+ E AA R
Sbjct: 340 RERLQAAEAYK---------SQLEEE---------RVLSGVLEASKALLEEQLE-AARER 380
Query: 923 IKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAV 982
RL + L L + L+ Q+ + EN+ L+ L Q+
Sbjct: 381 CARLHETQRENLL-LRTRLGEAHAELDSLRHQVDQLAEENVELE-LELQRSLEPPPGSPG 438
Query: 983 NEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQAR 1025
L+ +L +R+ RL E E R+ + L LQ +
Sbjct: 439 EAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQ 481
Score = 48.5 bits (114), Expect = 3e-05
Identities = 82/341 (24%), Positives = 137/341 (40%), Gaps = 43/341 (12%)
Query: 749 AEELREQLERE-KEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERL--- 804
+EE EQLE + LG + R+ F +H++ +Q + EV + +
Sbjct: 129 SEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVVLA 188
Query: 805 ------GQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQ 858
G+ A AELE L + L + S L R E + G + +E L +
Sbjct: 189 LSGPDPGELAP---AELEMLSRSLMGTLSKLAR----ERDLGAQRLAEL-LLEREPLCLR 240
Query: 859 LELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKA 918
E +A G + L N + +LR ++ +K A++ L + +
Sbjct: 241 PEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEK----------AELLLDSQAEVQG 290
Query: 919 AESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALED 978
E+ I+RLR + +A + +++E +E + L E G RLQ +R+ L+
Sbjct: 291 LEAEIRRLRQEAQALSGQAKRAELYREEAEA-----LRERAGRLPRLQEELRRCRERLQA 345
Query: 979 AQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVK 1038
A+A QL ER V+ E A EE+ A+ A L Q+ L ++
Sbjct: 346 AEAYKSQLEEER-----VLSGVLEASKALLEEQLEAARERCARLHETQRENL-----LLR 395
Query: 1039 TALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPST 1079
T L + SLR Q + + LE L++ P P +
Sbjct: 396 TRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGS 436
Score = 46.6 bits (109), Expect = 1e-04
Identities = 87/328 (26%), Positives = 142/328 (43%), Gaps = 60/328 (18%)
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVK----ETEKALS 610
+GP P EL E+E ++++ LA++RDL A+R+ E E
Sbjct: 190 SGPDPGELAPA----------ELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCL 239
Query: 611 RQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQ- 669
R R E HLA QL K A + L+QE + E + +QA+
Sbjct: 240 RPEAPSRAPAEGP-SHHLAL--QLANAK--------AQLRRLRQELEEKAELLLDSQAEV 288
Query: 670 --HELEIKKLK-ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRL 726
E EI++L+ E + + +A+R + E+ + ++E R + R ++E+RR
Sbjct: 289 QGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGR---------LPRLQEELRRC 339
Query: 727 KSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQ--HLEQEQW 784
+ E LQ+ E A + L + L LE K AL +++ E AR+R + ++E
Sbjct: 340 R-----ERLQAAE-AYKSQLEEERVLSGVLEASK-ALLEEQLEAARERCARLHETQRENL 392
Query: 785 ALQQQRQRLYSEVAEERERLGQQAARQRAELE-ELRQQLEESSSALTRALRA-------- 835
L+ + ++E+ R ++ Q A + ELE EL++ LE + A A
Sbjct: 393 LLRTRLGEAHAELDSLRHQV-DQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQD 451
Query: 836 ---EFEKGREEQERRHQMELNTLKQQLE 860
E E GR R EL L Q L+
Sbjct: 452 EVREAEAGRLRTLERENRELRGLLQVLQ 479
Score = 40.8 bits (94), Expect = 0.007
Identities = 78/338 (23%), Positives = 141/338 (41%), Gaps = 41/338 (12%)
Query: 553 PEAGPG---PLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKAL 609
P GP L+L + + RL+ E+EEK + +LL +A Q + RR+++ +AL
Sbjct: 248 PAEGPSHHLALQLAN-AKAQLRRLRQELEEKAE-LLLDSQAEVQGLEAEIRRLRQEAQAL 305
Query: 610 SRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQ 669
S Q +R A + R E+ + L E+ + L++E +RC ER+ A+A
Sbjct: 306 SGQAKR------AELYR---------EEAEALRERA-GRLPRLQEELRRCRERLQAAEA- 348
Query: 670 HELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSL 729
++ ++++ + L E ++ + E+ + +E R E + + L+ R RL
Sbjct: 349 YKSQLEEERVLSGVLEASK--ALLEEQLEAARERCARLHETQRENLLLR-----TRLGEA 401
Query: 730 HEAELLQSDERASQRCLRQAE---ELREQLEREKEALGQQERERARQRFQQHLEQEQWAL 786
H AEL + Q E EL+ LE + G+ A Q + + +
Sbjct: 402 H-AELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGR 460
Query: 787 QQQRQRLYSEVAEERERLGQQAARQRAELEELRQQ-----LEESSS---ALTRALRAEFE 838
+ +R E+ + L Q Q LE R+ LEE+ A + + +
Sbjct: 461 LRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQ 520
Query: 839 KGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEA 876
K R+ + + L LE + +A + +EA
Sbjct: 521 KARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEA 558
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 105 bits (262), Expect = 2e-22
Identities = 145/572 (25%), Positives = 243/572 (42%), Gaps = 84/572 (14%)
Query: 559 PLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQRE 618
PL +E + +K E ++ K L ++ A++++L + V ++ QLQ Q E
Sbjct: 839 PLLKSAETEKEMATMKEEFQKTKDE---LAKSEAKRKELEEKLVTLVQEKNDLQLQVQAE 895
Query: 619 HYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE--LEIKK 676
DQLI+ K L K + V + E++ E A+ + + E+KK
Sbjct: 896 SENLLDAEERC--DQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 953
Query: 677 -LKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAEL- 734
+ +L K +EK +E K + GL+ I KL +E + L+ H+ L
Sbjct: 954 DIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLT----REKKALQEAHQQALD 1009
Query: 735 -LQSDE-------RASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWA- 785
LQ++E + + +Q E+L LE+EK+ ER + + L QE
Sbjct: 1010 DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILD 1069
Query: 786 LQQQRQRLYSEV-------------AEERERLGQQAARQRAELEELRQQLEESSSALTRA 832
L+ +Q+L + E+ + LG Q ++ EL+ ++LEE A RA
Sbjct: 1070 LENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEA-ERA 1128
Query: 833 LRAEFEKGREEQERR----------------HQMELNTLKQQ--LELERQAWEAGRTRKE 874
RA+ EK R + R Q+ELN ++ L+L R EA +
Sbjct: 1129 TRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEA 1188
Query: 875 EAWLLNREQ-----ELREEI----RKGRDKEIELVIHRLEADMALAKEESEKAAESRIKR 925
L ++ EL E+I R + E E +LE D + ES +++ +++
Sbjct: 1189 MVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEK 1248
Query: 926 LRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQ 985
+ E +LSE ++Q SEL Q RLQ + R LE+ +++ Q
Sbjct: 1249 ICRTLEDQLSEARGKNEEIQRSLSELTTQ-------KSRLQTEAGELSRQLEEKESIVSQ 1301
Query: 986 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQA--------RQQLELE-EVHRR 1036
LS + Q Q+ E+ EEE + A LQ+ R+Q E E E
Sbjct: 1302 LSRSK----QAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAE 1357
Query: 1037 VKTALARKEEAVSSLRTQHEA-AVKRADHLEE 1067
++ AL++ V+ RT++E A++R + LEE
Sbjct: 1358 LQRALSKANSEVAQWRTKYETDAIQRTEELEE 1389
Score = 90.5 bits (223), Expect = 8e-18
Identities = 127/544 (23%), Positives = 245/544 (45%), Gaps = 61/544 (11%)
Query: 573 LKLEVEEKKQAMLLLQRALAQQRDLTAR-RVKETEKALSRQLQRQREHYEATIQRHLAFI 631
L+ + EE+++ LQRAL++ A+ R K A+ QR E EA ++ LA
Sbjct: 1344 LREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAI----QRTEELEEA--KKKLA-- 1395
Query: 632 DQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARR-- 689
Q ++D + E A A L++ QR V +++++ L +A +K +R
Sbjct: 1396 -QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLM----VDVERANSLAAALDKKQRNF 1450
Query: 690 EKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAEL--LQSDERASQRCLR 747
+K ++E K +E LE +++ + E+ +LK+ +E L L++ +R ++ +
Sbjct: 1451 DKVLAEWKTKCEESQAE-LEASLKESRSL-STELFKLKNAYEEALDQLETVKRENKNLEQ 1508
Query: 748 QAEELREQLEREKEALGQQERERA-----RQRFQQHLEQEQWALQQQRQ---RLYSEVAE 799
+ +L EQ+ + + + E+ R + Q LE+ + AL+ + R+ E+ +
Sbjct: 1509 EIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQ 1568
Query: 800 ERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQME--LNTLKQ 857
+ + ++ A + E+E+L++ + + + AL AE E + +ME LN ++
Sbjct: 1569 VKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEI 1628
Query: 858 QL-ELERQAWEA-GRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEES 915
QL RQA E R + L + + L + +R D + +L I A++ A+ E
Sbjct: 1629 QLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEE 1688
Query: 916 EKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKER- 974
+A + +R R E EL + + + L + + L + E + ++LQ V R
Sbjct: 1689 LRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRD 1748
Query: 975 ----------ALEDAQAVNEQLSSE----------RSNLAQVIRQEFEDRLAASEE-ETR 1013
A+ DA + E+L E + NL Q ++ + + RL +E+ +
Sbjct: 1749 ARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK-DLQHRLDEAEQLALK 1807
Query: 1014 QAKAELATLQAR-QQLELEEVHRRVKT-----ALARKEEAVSSLRTQHEAAVKRADHLEE 1067
K ++ L+ R ++LE E + K L + E V L Q E K L++
Sbjct: 1808 GGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQD 1867
Query: 1068 LLEQ 1071
L+++
Sbjct: 1868 LVDK 1871
Score = 63.5 bits (153), Expect = 1e-09
Identities = 86/368 (23%), Positives = 159/368 (43%), Gaps = 51/368 (13%)
Query: 747 RQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQ 806
++ ++E+ ++ K+ L + E +R + LE++ L Q++ L +V E E L
Sbjct: 848 KEMATMKEEFQKTKDELAKSEAKR------KELEEKLVTLVQEKNDLQLQVQAESENL-L 900
Query: 807 QAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAW 866
A + +L + + QLE +T E E E ++ ++E + + +++
Sbjct: 901 DAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 960
Query: 867 EAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEA-----DMALAKEESEKAAES 921
+ KE+ N+ + L EE+ G D+ I + +A AL ++E+ +
Sbjct: 961 TLAKVEKEKHATENKVKNLTEEL-SGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVN 1019
Query: 922 RIKRLRDKYEAELSELEQS---ERKL----QERCSELKGQLGEAEGENLRLQGLVRQKER 974
+ + + K E ++ +LE S E+KL + +L+G L A+ L L+ +Q +
Sbjct: 1020 SLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDE 1079
Query: 975 ALEDAQAVNEQLSS---ERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQL--- 1028
L+ QL S + L +++ ++ A EE + +AE AT ++
Sbjct: 1080 RLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSD 1139
Query: 1029 ---ELEEVHRRVKTA---------LARKEEA--------VSSLRTQHEAAV-----KRAD 1063
ELEE+ R++ A L +K EA + QHEA V K AD
Sbjct: 1140 YARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHAD 1199
Query: 1064 HLEELLEQ 1071
+ EL EQ
Sbjct: 1200 SVAELGEQ 1207
Score = 53.1 bits (126), Expect = 1e-06
Identities = 68/302 (22%), Positives = 128/302 (42%), Gaps = 73/302 (24%)
Query: 815 LEELRQ----QLEESSSALTRA--LRAEFEKGREEQERRHQMELNTLKQQLELERQAW-- 866
LEE+R +L + A+ R +R EF+K + +E ++ N ++ + ++ W
Sbjct: 774 LEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYN-IRSFMNVKHWPWMK 832
Query: 867 ---------EAGRTRKEEAWLLNREQELREEIRKGRDKEIEL---------------VIH 902
++ T KE A + Q+ ++E+ K K EL +
Sbjct: 833 LFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQV 892
Query: 903 RLEADMALAKEE-------SEKAAESRIKRLRDKYEAEL---SELEQSERKLQERCSELK 952
+ E++ L EE ++ E++IK + ++ E E +EL +RKL++ CSELK
Sbjct: 893 QAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 952
Query: 953 GQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEET 1012
+ + E L L + ++K + + E+LS +A++ T
Sbjct: 953 KDIDDLE---LTLAKVEKEKHATENKVKNLTEELSGLDETIAKL---------------T 994
Query: 1013 RQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQH 1072
R+ KA L+E H++ L +E+ V+SL ++ + LE LEQ
Sbjct: 995 REKKA------------LQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQE 1042
Query: 1073 RR 1074
++
Sbjct: 1043 KK 1044
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 105 bits (262), Expect = 2e-22
Identities = 132/576 (22%), Positives = 260/576 (45%), Gaps = 65/576 (11%)
Query: 525 KLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGS-----EVSTSVMRLKLEVEE 579
+L+ S L E + Q+QL ++ E + EA + L + E M +LE EE
Sbjct: 877 ELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEMEARLEEEE 935
Query: 580 KKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH----LAFIDQ-- 633
+ L +R Q+ L E E+A ++LQ ++ EA I++ L DQ
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 995
Query: 634 -LIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKW 692
L +++K+L E+ + L +E+++ + + + + +HE I +L+ + EK+R+E
Sbjct: 996 KLSKERKLLEERISDLTTNLAEEEEKA-KNLTKLKNKHESMISELEVRLKKEEKSRQEL- 1053
Query: 693 ISEKTKKIKEVTVRGLEPEIQKL---IARHKQEVRRLKSLHEAELLQSDERASQR--CLR 747
EK K+ E +I L IA K ++ + + +A L + D+ +Q+ L+
Sbjct: 1054 --EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1111
Query: 748 QAEELREQLEREKEALGQQERERARQRFQQH-LEQEQWALQQQRQRLYSEVAEERERLGQ 806
+ EL + +E L + R + Q+ L +E AL+ + + A ++E
Sbjct: 1112 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL--- 1168
Query: 807 QAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAW 866
A++ E+ L++ L+E TR+ A+ + E ++H + L +QLE ++A
Sbjct: 1169 -RAKREQEVTVLKKALDEE----TRSHEAQVQ----EMRQKHAQAVEELTEQLEQFKRA- 1218
Query: 867 EAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRL 926
K + L +L E+R V+ + + ++ E +K E++++ L
Sbjct: 1219 -KANLDKNKQTLEKENADLAGELR---------VLGQAKQEV----EHKKKKLEAQVQEL 1264
Query: 927 RDKY---EAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVN 983
+ K E +EL KLQ + G L EAEG+ ++L V L+D Q +
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324
Query: 984 EQLSSERSNLAQVIRQEFEDRLAASE--EETRQAKAELATLQARQQLELEEVHRRVKTAL 1041
++ + ++ N++ +RQ E+R + + +E +AK L + ++L + ++++
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384
Query: 1042 A----------RKEEAVSSLRTQHEAAVKRADHLEE 1067
+ R ++ + +L Q+E D LE+
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420
Score = 104 bits (260), Expect = 4e-22
Identities = 196/865 (22%), Positives = 350/865 (40%), Gaps = 137/865 (15%)
Query: 292 RLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRA 351
+++ LLQ R+E+ ++ E L QK R++ E + ++ + Q ++K L+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDEL-----QKTKERQQKAENELKELEQKHSQLTEEKNLLQE 894
Query: 352 QKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGP--GDR 409
Q + E R+ +Q +E+ + + G L A +
Sbjct: 895 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE---EDRGQQLQAERKKMAQQ 951
Query: 410 CLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLE-----MMAPSRGSAKSRGPLEELLH-- 462
L + E + + + + +A LE M + +K R LEE +
Sbjct: 952 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011
Query: 463 TLQLLEKEPDV--LPRPRTHHRGRYAWASEEDDASSLTADNLEKF-----GKLSAFPEPP 515
T L E+E L + + H + + LEK G S F E
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 516 ED----------GTLLSEAKLQSIMSFLDE------------MEKSG-----QDQLDSQQ 548
D E +LQ+ ++ LD+ E G Q+ LDS++
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131
Query: 549 EGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKET--- 605
+A +LG E+ LK E+E+ + A Q++L A+R +E
Sbjct: 1132 AAR-NKAEKQKRDLGEELEA----LKTELEDTLDST-------ATQQELRAKREQEVTVL 1179
Query: 606 EKALSRQLQRQREHYEATIQRHLAFIDQLIE--------------DKKVLSEKCEAVVAE 651
+KAL + + + Q+H +++L E +K+ L ++ + E
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 652 LKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEV--TVRGLE 709
L+ Q + V + + E ++++L+ S E+AR E +++K K++ +V G+
Sbjct: 1240 LRVLGQ-AKQEVEHKKKKLEAQVQELQSKCSDGERARAE--LNDKVHKLQNEVESVTGML 1296
Query: 710 PEIQKLIARHKQEVRRLKSLHE--AELLQSDERASQRCLRQAEELREQLEREKEALGQQ- 766
E + + ++V L S + ELLQ + R L + +LR QLE E+ +L Q
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK---LNVSTKLR-QLEEERNSLQDQL 1352
Query: 767 -ERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEES 825
E A+Q ++H+ L +++L + A E L + R + E+E L QQ EE
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKL-QDFASTVEALEEGKKRFQKEIENLTQQYEEK 1411
Query: 826 SSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQ-AWEAGRTRKEEAWLLNREQE 884
++A + E+ + R Q EL+ L L+ +RQ + +++ LL E+
Sbjct: 1412 AAAYDKL---------EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 885 LREEIRKGRDK-EIE--------LVIHRLEADMALAKEESE------KAAESRIKRLRDK 929
+ + RD+ E E L + R + AKEE E KA + +D
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 930 YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSE 989
+ ELE+S+R L+ + E+K QL E E E +A EDA+ E
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDEL-----------QATEDAKLRLEV---- 1567
Query: 990 RSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVS 1049
N+ Q ++ +FE L A +E+ + + +L + ELE+ ++ A A K++
Sbjct: 1568 --NM-QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 1050 SLRTQHEAAVKRADHLEELLEQHRR 1074
L+ A EE ++Q R+
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRK 1649
Score = 100 bits (249), Expect = 7e-21
Identities = 198/885 (22%), Positives = 370/885 (41%), Gaps = 162/885 (18%)
Query: 250 LPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG---AGAARLEHLLQAKREEQRQ 306
L + K E +A F Q+ I ++ A ARL+ + K ++
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 307 -RSGEGTLLDLHQQ---KEAARRKAREEKAR-----QARRAAIQEL-------QQKRALR 350
R EG + DL + + AAR KA ++K +A + +++ Q+ RA R
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 351 AQKASTAERGPPENPR--ETRVPGMRQP--------AQELSPTPGGTAH-----QALKAN 395
Q+ + ++ E R E +V MRQ ++L A+ Q L+
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 396 NT--GGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKS 453
N G L G + +Q E + + + AQ E+ + ++
Sbjct: 1233 NADLAGELRVLG-------------QAKQEVEHKKKKLEAQVQ-----ELQSKCSDGERA 1274
Query: 454 RGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPE 513
R L + +H LQ E + + G+ A L D +L E
Sbjct: 1275 RAELNDKVHKLQ---NEVESVTGMLNEAEGK---------AIKLAKDVASLSSQLQDTQE 1322
Query: 514 PPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRL 573
++ T + + + + L+E S QDQLD + E + E S + +
Sbjct: 1323 LLQEETR-QKLNVSTKLRQLEEERNSLQDQLDEEMEA----------KQNLERHISTLNI 1371
Query: 574 KLEVEEKK-QAMLLLQRALAQQRDLTARRVK------ETEKALSRQLQRQREHYEATIQR 626
+L +KK Q AL + + + ++ E + A +L++ + + +
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 627 HLAFID---QLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSA 683
+ +D QL+ + + K + ++AE K + + +A+A+ + K L A
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 684 TEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQ 743
E+A K E+T K+ L+ E++ L++ K +V K++HE E S+
Sbjct: 1492 LEEALEAKEELERTNKM-------LKAEMEDLVSS-KDDVG--KNVHELE-------KSK 1534
Query: 744 RCLR-QAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERE 802
R L Q EE++ QLE ++ L Q E A+ R + +++ + ++ Q + E+R
Sbjct: 1535 RALETQMEEMKTQLEELEDEL--QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1592
Query: 803 RLGQQAARQRAELEELRQQLEESSSALTRA--------LRAEFE-KGREEQERRHQMELN 853
+L +Q ELE+ R+Q +++A + L+A+ KGREE + +L
Sbjct: 1593 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK----QLR 1648
Query: 854 TLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKE 913
L+ Q++ ++ E R ++E + +E E + K +E + +L+ D+A A E
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKA-------KSLEADLMQLQEDLAAA-E 1700
Query: 914 ESEKAAESRIKRLRDKYEAELS---ELEQSERKLQERCSELKGQLGEAEGENLRLQGLVR 970
+ K A+ + L ++ + LS L+ +R+L+ R ++L+ +L E +G + VR
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 971 QKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLEL 1030
+A + A+ ++ +L++ERS A + E+ ARQQLE
Sbjct: 1761 ---KATQQAEQLSNELATERST--------------AQKNES-----------ARQQLER 1792
Query: 1031 EEVHRRVKTALARKEEAVSSLRTQHEAAVK-RADHLEELLEQHRR 1074
+ ++ +++ L E AV S AA++ + LEE +EQ R
Sbjct: 1793 Q--NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Score = 95.9 bits (237), Expect = 2e-19
Identities = 157/627 (25%), Positives = 268/627 (42%), Gaps = 124/627 (19%)
Query: 421 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQL-LEKEPDVLPRPRT 479
Q+ E+ TQ + AA D LE K++ L++ L L + L+ + ++
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLE---------KTKNRLQQELDDLVVDLDNQRQLVSNLEK 1448
Query: 480 HHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKS 539
R +EE + SS AD ++ A E L L+ + +E+E++
Sbjct: 1449 KQRKFDQLLAEEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERT 1505
Query: 540 GQDQLDSQQEGWVP---EAGPGPLELGS----------EVSTSVMRLKLEVEEKKQAMLL 586
+ L ++ E V + G EL E+ T + L+ E++ + A L
Sbjct: 1506 NK-MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564
Query: 587 LQ---RALAQQ--RDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVL 641
L+ +AL Q RDL AR + EK RQLQRQ YE + ED++
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKR--RQLQRQLHEYETEL-----------EDER-- 1609
Query: 642 SEKCEAVVAELKQE-DQRCTERVAQAQAQ-HELEIKKLKELMSATEKARREKWISEKTKK 699
++ A A+ K E D + E A + + E IK+L++L + + +RE + ++
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR- 1668
Query: 700 IKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLERE 759
++ A K+ ++ KSL EA+L+Q E L AE R+Q + E
Sbjct: 1669 -------------DEIFATAKENEKKAKSL-EADLMQLQED-----LAAAERARKQADLE 1709
Query: 760 KEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELR 819
KE L ++ R ALQ +++RL + +A+ E L ++ A + +R
Sbjct: 1710 KEELAEELASSLSGRN---------ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 820 ---QQLEESSSALT--RALRAEFEKGREEQERR--------HQMELNTLKQQLELERQAW 866
QQ E+ S+ L R+ + E R++ ER+ H+ME +K + + A
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME-GAVKSKFKSTIAAL 1819
Query: 867 EAGRTRKEEAWLLNREQELREEIR-----KGRDKEIELVIHRLEADMALAKEESEKAAES 921
EA + EE EQE RE+ K +DK+++ ++ ++E + +A++ E+A
Sbjct: 1820 EAKIAQLEE----QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA--- 1872
Query: 922 RIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQA 981
K R +LK QL EAE E+ R+ R+ +R L++A
Sbjct: 1873 --------------------EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1912
Query: 982 VNEQLSSERSNLAQVIRQEFEDRLAAS 1008
NE + E + L +R+ E S
Sbjct: 1913 SNEAMGREVNALKSKLRRGNETSFVPS 1939
Score = 89.0 bits (219), Expect = 2e-17
Identities = 167/784 (21%), Positives = 337/784 (42%), Gaps = 101/784 (12%)
Query: 297 LQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQEL-QQKRALRAQKAS 355
L+AKRE+ E T+L +E +A+ ++ RQ A++EL +Q + KA+
Sbjct: 1168 LRAKREQ------EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN 1221
Query: 356 ------TAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDR 409
T E+ + E RV G + E Q L++ + G A D+
Sbjct: 1222 LDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1281
Query: 410 C--LPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLL 467
L S + LA+D A + ++ + + L+ L
Sbjct: 1282 VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1341
Query: 468 EKEPDVLPRPRTHHRGRYAWASEEDDASSLT---ADNLEKFGKLSAFPEPPEDGTLLSEA 524
E+E + L A + E S+L +D+ +K ++ E E+G +
Sbjct: 1342 EEERNSLQDQLDEEME--AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1399
Query: 525 KLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAM 584
+++++ +E + + D+L+ + E ++L ++ R + EKKQ
Sbjct: 1400 EIENLTQQYEE-KAAAYDKLEKTKNRLQQELDDLVVDLDNQ------RQLVSNLEKKQRK 1452
Query: 585 LLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEK 644
+ LA++++++++ E ++A + R++E ++ R L ++ +E K+ L
Sbjct: 1453 F--DQLLAEEKNISSKYADERDRAEAEA--REKETKALSLARAL---EEALEAKEELERT 1505
Query: 645 CEAVVAELKQEDQRCTERVAQAQAQHELEIKK------LKELMSATEKARREKWISEKTK 698
+ + AE+ + + + + HELE K ++E+ + E+ E +E K
Sbjct: 1506 NKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 699 KIKEVTVRGLEPEIQK-LIARHKQ--EVRRL--KSLHEAELLQSDERASQRCLRQAEELR 753
EV ++ L+ + ++ L AR +Q E RR + LHE E DER + A++
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Query: 754 E------QLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQ 807
E +L+ + G++E + ++ Q ++ Q L+ R A +E
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN---- 1678
Query: 808 AARQRAELEELRQQLEESSSALTRALR-AEFEK------------GR---EEQERRHQME 851
++ LE QL+E +A RA + A+ EK GR ++++RR +
Sbjct: 1679 -EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1737
Query: 852 LNTLKQQLELERQAWEA--GRTRK--EEAWLLNRE-----------QELREEIRKGRDKE 896
+ L+++LE E+ EA R RK ++A L+ E + R+++ + ++KE
Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER-QNKE 1796
Query: 897 IELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLG 956
+ +H +E + + + A E++I +L ++ E E E + + + L+++ +LK L
Sbjct: 1797 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856
Query: 957 EAEGENLRLQ----------GLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLA 1006
+ E E + V+Q +R LE+A+ ++++++ R L + + + E A
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1916
Query: 1007 ASEE 1010
E
Sbjct: 1917 MGRE 1920
Score = 85.9 bits (211), Expect = 2e-16
Identities = 108/449 (24%), Positives = 195/449 (43%), Gaps = 70/449 (15%)
Query: 662 RVAQAQAQHELE-IKKLKELMSATEKARREKW--ISEKTKKIKEVT-----VRGLEPEIQ 713
R A A+ Q +L +K ++ +A K R +W + K K + +VT ++ E E+Q
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 862
Query: 714 KLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQ 773
K R ++ LK L + ++E+ L+EQL+ E E + E R R
Sbjct: 863 KTKERQQKAENELKELEQKHSQLTEEK---------NLLQEQLQAETELYAEAEEMRVRL 913
Query: 774 RFQ-QHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRA 832
+ Q LE+ L + RL EE E GQQ +R ++ + LEE
Sbjct: 914 AAKKQELEE---ILHEMEARL-----EEEEDRGQQLQAERKKMAQQMLDLEEQLE----- 960
Query: 833 LRAEFEKGREEQERRHQMELNTLKQQLELERQAWEA-------GRTRKEEAWLLNREQEL 885
EE+ R +++L + + ++++ E + KE L R +L
Sbjct: 961 ---------EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011
Query: 886 REEIRKGRDKEIELVIHRLEADMALAKEE----SEKAAESRIKRLRDKYEAELSELEQSE 941
+ + +K L + + + +++ E E+ + +++L+ K E + S+ +
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 942 RKLQERCSELKGQLGEAEGE----NLRLQGLVRQKERALEDAQA-------VNEQLSSER 990
LQ + +ELK QL + E E RL + QK AL+ + + E L SER
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131
Query: 991 S--NLAQVIRQEFEDRLAASE---EETRQAKAELATLQARQQLELEEVHRRVKTALARKE 1045
+ N A+ +++ + L A + E+T + A L+A+++ E+ + + + E
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191
Query: 1046 EAVSSLRTQHEAAVKRADHLEELLEQHRR 1074
V +R +H AV + L E LEQ +R
Sbjct: 1192 AQVQEMRQKHAQAV---EELTEQLEQFKR 1217
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 105 bits (262), Expect = 2e-22
Identities = 132/576 (22%), Positives = 260/576 (45%), Gaps = 65/576 (11%)
Query: 525 KLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGS-----EVSTSVMRLKLEVEE 579
+L+ S L E + Q+QL ++ E + EA + L + E M +LE EE
Sbjct: 884 ELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEMEARLEEEE 942
Query: 580 KKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH----LAFIDQ-- 633
+ L +R Q+ L E E+A ++LQ ++ EA I++ L DQ
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 1002
Query: 634 -LIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKW 692
L +++K+L E+ + L +E+++ + + + + +HE I +L+ + EK+R+E
Sbjct: 1003 KLSKERKLLEERISDLTTNLAEEEEKA-KNLTKLKNKHESMISELEVRLKKEEKSRQEL- 1060
Query: 693 ISEKTKKIKEVTVRGLEPEIQKL---IARHKQEVRRLKSLHEAELLQSDERASQR--CLR 747
EK K+ E +I L IA K ++ + + +A L + D+ +Q+ L+
Sbjct: 1061 --EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1118
Query: 748 QAEELREQLEREKEALGQQERERARQRFQQH-LEQEQWALQQQRQRLYSEVAEERERLGQ 806
+ EL + +E L + R + Q+ L +E AL+ + + A ++E
Sbjct: 1119 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL--- 1175
Query: 807 QAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAW 866
A++ E+ L++ L+E TR+ A+ + E ++H + L +QLE ++A
Sbjct: 1176 -RAKREQEVTVLKKALDEE----TRSHEAQVQ----EMRQKHAQAVEELTEQLEQFKRA- 1225
Query: 867 EAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRL 926
K + L +L E+R V+ + + ++ E +K E++++ L
Sbjct: 1226 -KANLDKNKQTLEKENADLAGELR---------VLGQAKQEV----EHKKKKLEAQVQEL 1271
Query: 927 RDKY---EAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVN 983
+ K E +EL KLQ + G L EAEG+ ++L V L+D Q +
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331
Query: 984 EQLSSERSNLAQVIRQEFEDRLAASE--EETRQAKAELATLQARQQLELEEVHRRVKTAL 1041
++ + ++ N++ +RQ E+R + + +E +AK L + ++L + ++++
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391
Query: 1042 A----------RKEEAVSSLRTQHEAAVKRADHLEE 1067
+ R ++ + +L Q+E D LE+
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Score = 104 bits (260), Expect = 4e-22
Identities = 196/865 (22%), Positives = 350/865 (40%), Gaps = 137/865 (15%)
Query: 292 RLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRA 351
+++ LLQ R+E+ ++ E L QK R++ E + ++ + Q ++K L+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDEL-----QKTKERQQKAENELKELEQKHSQLTEEKNLLQE 901
Query: 352 QKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGP--GDR 409
Q + E R+ +Q +E+ + + G L A +
Sbjct: 902 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE---EDRGQQLQAERKKMAQQ 958
Query: 410 CLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLE-----MMAPSRGSAKSRGPLEELLH-- 462
L + E + + + + +A LE M + +K R LEE +
Sbjct: 959 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018
Query: 463 TLQLLEKEPDV--LPRPRTHHRGRYAWASEEDDASSLTADNLEKF-----GKLSAFPEPP 515
T L E+E L + + H + + LEK G S F E
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 516 ED----------GTLLSEAKLQSIMSFLDE------------MEKSG-----QDQLDSQQ 548
D E +LQ+ ++ LD+ E G Q+ LDS++
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 549 EGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKET--- 605
+A +LG E+ LK E+E+ + A Q++L A+R +E
Sbjct: 1139 AAR-NKAEKQKRDLGEELEA----LKTELEDTLDST-------ATQQELRAKREQEVTVL 1186
Query: 606 EKALSRQLQRQREHYEATIQRHLAFIDQLIE--------------DKKVLSEKCEAVVAE 651
+KAL + + + Q+H +++L E +K+ L ++ + E
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 652 LKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEV--TVRGLE 709
L+ Q + V + + E ++++L+ S E+AR E +++K K++ +V G+
Sbjct: 1247 LRVLGQ-AKQEVEHKKKKLEAQVQELQSKCSDGERARAE--LNDKVHKLQNEVESVTGML 1303
Query: 710 PEIQKLIARHKQEVRRLKSLHE--AELLQSDERASQRCLRQAEELREQLEREKEALGQQ- 766
E + + ++V L S + ELLQ + R L + +LR QLE E+ +L Q
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK---LNVSTKLR-QLEEERNSLQDQL 1359
Query: 767 -ERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEES 825
E A+Q ++H+ L +++L + A E L + R + E+E L QQ EE
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKL-QDFASTVEALEEGKKRFQKEIENLTQQYEEK 1418
Query: 826 SSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQ-AWEAGRTRKEEAWLLNREQE 884
++A + E+ + R Q EL+ L L+ +RQ + +++ LL E+
Sbjct: 1419 AAAYDKL---------EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 885 LREEIRKGRDK-EIE--------LVIHRLEADMALAKEESE------KAAESRIKRLRDK 929
+ + RD+ E E L + R + AKEE E KA + +D
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529
Query: 930 YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSE 989
+ ELE+S+R L+ + E+K QL E E E +A EDA+ E
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQLEELEDEL-----------QATEDAKLRLEV---- 1574
Query: 990 RSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVS 1049
N+ Q ++ +FE L A +E+ + + +L + ELE+ ++ A A K++
Sbjct: 1575 --NM-QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 1050 SLRTQHEAAVKRADHLEELLEQHRR 1074
L+ A EE ++Q R+
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRK 1656
Score = 100 bits (249), Expect = 7e-21
Identities = 198/885 (22%), Positives = 370/885 (41%), Gaps = 162/885 (18%)
Query: 250 LPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG---AGAARLEHLLQAKREEQRQ 306
L + K E +A F Q+ I ++ A ARL+ + K ++
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 307 -RSGEGTLLDLHQQ---KEAARRKAREEKAR-----QARRAAIQEL-------QQKRALR 350
R EG + DL + + AAR KA ++K +A + +++ Q+ RA R
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 351 AQKASTAERGPPENPR--ETRVPGMRQP--------AQELSPTPGGTAH-----QALKAN 395
Q+ + ++ E R E +V MRQ ++L A+ Q L+
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 396 NT--GGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKS 453
N G L G + +Q E + + + AQ E+ + ++
Sbjct: 1240 NADLAGELRVLG-------------QAKQEVEHKKKKLEAQVQ-----ELQSKCSDGERA 1281
Query: 454 RGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPE 513
R L + +H LQ E + + G+ A L D +L E
Sbjct: 1282 RAELNDKVHKLQ---NEVESVTGMLNEAEGK---------AIKLAKDVASLSSQLQDTQE 1329
Query: 514 PPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRL 573
++ T + + + + L+E S QDQLD + E + E S + +
Sbjct: 1330 LLQEETR-QKLNVSTKLRQLEEERNSLQDQLDEEMEA----------KQNLERHISTLNI 1378
Query: 574 KLEVEEKK-QAMLLLQRALAQQRDLTARRVK------ETEKALSRQLQRQREHYEATIQR 626
+L +KK Q AL + + + ++ E + A +L++ + + +
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 627 HLAFID---QLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSA 683
+ +D QL+ + + K + ++AE K + + +A+A+ + K L A
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 684 TEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQ 743
E+A K E+T K+ L+ E++ L++ K +V K++HE E S+
Sbjct: 1499 LEEALEAKEELERTNKM-------LKAEMEDLVSS-KDDVG--KNVHELE-------KSK 1541
Query: 744 RCLR-QAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERE 802
R L Q EE++ QLE ++ L Q E A+ R + +++ + ++ Q + E+R
Sbjct: 1542 RALETQMEEMKTQLEELEDEL--QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1599
Query: 803 RLGQQAARQRAELEELRQQLEESSSALTRA--------LRAEFE-KGREEQERRHQMELN 853
+L +Q ELE+ R+Q +++A + L+A+ KGREE + +L
Sbjct: 1600 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK----QLR 1655
Query: 854 TLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKE 913
L+ Q++ ++ E R ++E + +E E + K +E + +L+ D+A A E
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKA-------KSLEADLMQLQEDLAAA-E 1707
Query: 914 ESEKAAESRIKRLRDKYEAELS---ELEQSERKLQERCSELKGQLGEAEGENLRLQGLVR 970
+ K A+ + L ++ + LS L+ +R+L+ R ++L+ +L E +G + VR
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 971 QKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLEL 1030
+A + A+ ++ +L++ERS A + E+ ARQQLE
Sbjct: 1768 ---KATQQAEQLSNELATERST--------------AQKNES-----------ARQQLER 1799
Query: 1031 EEVHRRVKTALARKEEAVSSLRTQHEAAVK-RADHLEELLEQHRR 1074
+ ++ +++ L E AV S AA++ + LEE +EQ R
Sbjct: 1800 Q--NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Score = 95.9 bits (237), Expect = 2e-19
Identities = 157/627 (25%), Positives = 268/627 (42%), Gaps = 124/627 (19%)
Query: 421 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQL-LEKEPDVLPRPRT 479
Q+ E+ TQ + AA D LE K++ L++ L L + L+ + ++
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLE---------KTKNRLQQELDDLVVDLDNQRQLVSNLEK 1455
Query: 480 HHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKS 539
R +EE + SS AD ++ A E L L+ + +E+E++
Sbjct: 1456 KQRKFDQLLAEEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERT 1512
Query: 540 GQDQLDSQQEGWVP---EAGPGPLELGS----------EVSTSVMRLKLEVEEKKQAMLL 586
+ L ++ E V + G EL E+ T + L+ E++ + A L
Sbjct: 1513 NK-MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571
Query: 587 LQ---RALAQQ--RDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVL 641
L+ +AL Q RDL AR + EK RQLQRQ YE + ED++
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKR--RQLQRQLHEYETEL-----------EDER-- 1616
Query: 642 SEKCEAVVAELKQE-DQRCTERVAQAQAQ-HELEIKKLKELMSATEKARREKWISEKTKK 699
++ A A+ K E D + E A + + E IK+L++L + + +RE + ++
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR- 1675
Query: 700 IKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLERE 759
++ A K+ ++ KSL EA+L+Q E L AE R+Q + E
Sbjct: 1676 -------------DEIFATAKENEKKAKSL-EADLMQLQED-----LAAAERARKQADLE 1716
Query: 760 KEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELR 819
KE L ++ R ALQ +++RL + +A+ E L ++ A + +R
Sbjct: 1717 KEELAEELASSLSGRN---------ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 820 ---QQLEESSSALT--RALRAEFEKGREEQERR--------HQMELNTLKQQLELERQAW 866
QQ E+ S+ L R+ + E R++ ER+ H+ME +K + + A
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME-GAVKSKFKSTIAAL 1826
Query: 867 EAGRTRKEEAWLLNREQELREEIR-----KGRDKEIELVIHRLEADMALAKEESEKAAES 921
EA + EE EQE RE+ K +DK+++ ++ ++E + +A++ E+A
Sbjct: 1827 EAKIAQLEE----QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA--- 1879
Query: 922 RIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQA 981
K R +LK QL EAE E+ R+ R+ +R L++A
Sbjct: 1880 --------------------EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1919
Query: 982 VNEQLSSERSNLAQVIRQEFEDRLAAS 1008
NE + E + L +R+ E S
Sbjct: 1920 SNEAMGREVNALKSKLRRGNETSFVPS 1946
Score = 89.0 bits (219), Expect = 2e-17
Identities = 167/784 (21%), Positives = 337/784 (42%), Gaps = 101/784 (12%)
Query: 297 LQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQEL-QQKRALRAQKAS 355
L+AKRE+ E T+L +E +A+ ++ RQ A++EL +Q + KA+
Sbjct: 1175 LRAKREQ------EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN 1228
Query: 356 ------TAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDR 409
T E+ + E RV G + E Q L++ + G A D+
Sbjct: 1229 LDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1288
Query: 410 C--LPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLL 467
L S + LA+D A + ++ + + L+ L
Sbjct: 1289 VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1348
Query: 468 EKEPDVLPRPRTHHRGRYAWASEEDDASSLT---ADNLEKFGKLSAFPEPPEDGTLLSEA 524
E+E + L A + E S+L +D+ +K ++ E E+G +
Sbjct: 1349 EEERNSLQDQLDEEME--AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406
Query: 525 KLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAM 584
+++++ +E + + D+L+ + E ++L ++ R + EKKQ
Sbjct: 1407 EIENLTQQYEE-KAAAYDKLEKTKNRLQQELDDLVVDLDNQ------RQLVSNLEKKQRK 1459
Query: 585 LLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEK 644
+ LA++++++++ E ++A + R++E ++ R L ++ +E K+ L
Sbjct: 1460 F--DQLLAEEKNISSKYADERDRAEAEA--REKETKALSLARAL---EEALEAKEELERT 1512
Query: 645 CEAVVAELKQEDQRCTERVAQAQAQHELEIKK------LKELMSATEKARREKWISEKTK 698
+ + AE+ + + + + HELE K ++E+ + E+ E +E K
Sbjct: 1513 NKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 699 KIKEVTVRGLEPEIQK-LIARHKQ--EVRRL--KSLHEAELLQSDERASQRCLRQAEELR 753
EV ++ L+ + ++ L AR +Q E RR + LHE E DER + A++
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Query: 754 E------QLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQ 807
E +L+ + G++E + ++ Q ++ Q L+ R A +E
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN---- 1685
Query: 808 AARQRAELEELRQQLEESSSALTRALR-AEFEK------------GR---EEQERRHQME 851
++ LE QL+E +A RA + A+ EK GR ++++RR +
Sbjct: 1686 -EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1744
Query: 852 LNTLKQQLELERQAWEA--GRTRK--EEAWLLNRE-----------QELREEIRKGRDKE 896
+ L+++LE E+ EA R RK ++A L+ E + R+++ + ++KE
Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER-QNKE 1803
Query: 897 IELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLG 956
+ +H +E + + + A E++I +L ++ E E E + + + L+++ +LK L
Sbjct: 1804 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863
Query: 957 EAEGENLRLQ----------GLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLA 1006
+ E E + V+Q +R LE+A+ ++++++ R L + + + E A
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1923
Query: 1007 ASEE 1010
E
Sbjct: 1924 MGRE 1927
Score = 85.9 bits (211), Expect = 2e-16
Identities = 108/449 (24%), Positives = 195/449 (43%), Gaps = 70/449 (15%)
Query: 662 RVAQAQAQHELE-IKKLKELMSATEKARREKW--ISEKTKKIKEVT-----VRGLEPEIQ 713
R A A+ Q +L +K ++ +A K R +W + K K + +VT ++ E E+Q
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 869
Query: 714 KLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQ 773
K R ++ LK L + ++E+ L+EQL+ E E + E R R
Sbjct: 870 KTKERQQKAENELKELEQKHSQLTEEK---------NLLQEQLQAETELYAEAEEMRVRL 920
Query: 774 RFQ-QHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRA 832
+ Q LE+ L + RL EE E GQQ +R ++ + LEE
Sbjct: 921 AAKKQELEE---ILHEMEARL-----EEEEDRGQQLQAERKKMAQQMLDLEEQLE----- 967
Query: 833 LRAEFEKGREEQERRHQMELNTLKQQLELERQAWEA-------GRTRKEEAWLLNREQEL 885
EE+ R +++L + + ++++ E + KE L R +L
Sbjct: 968 ---------EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018
Query: 886 REEIRKGRDKEIELVIHRLEADMALAKEE----SEKAAESRIKRLRDKYEAELSELEQSE 941
+ + +K L + + + +++ E E+ + +++L+ K E + S+ +
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 942 RKLQERCSELKGQLGEAEGE----NLRLQGLVRQKERALEDAQA-------VNEQLSSER 990
LQ + +ELK QL + E E RL + QK AL+ + + E L SER
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 991 S--NLAQVIRQEFEDRLAASE---EETRQAKAELATLQARQQLELEEVHRRVKTALARKE 1045
+ N A+ +++ + L A + E+T + A L+A+++ E+ + + + E
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198
Query: 1046 EAVSSLRTQHEAAVKRADHLEELLEQHRR 1074
V +R +H AV + L E LEQ +R
Sbjct: 1199 AQVQEMRQKHAQAV---EELTEQLEQFKR 1224
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 105 bits (262), Expect = 2e-22
Identities = 132/576 (22%), Positives = 260/576 (45%), Gaps = 65/576 (11%)
Query: 525 KLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGS-----EVSTSVMRLKLEVEE 579
+L+ S L E + Q+QL ++ E + EA + L + E M +LE EE
Sbjct: 884 ELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEMEARLEEEE 942
Query: 580 KKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH----LAFIDQ-- 633
+ L +R Q+ L E E+A ++LQ ++ EA I++ L DQ
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 1002
Query: 634 -LIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKW 692
L +++K+L E+ + L +E+++ + + + + +HE I +L+ + EK+R+E
Sbjct: 1003 KLSKERKLLEERISDLTTNLAEEEEKA-KNLTKLKNKHESMISELEVRLKKEEKSRQEL- 1060
Query: 693 ISEKTKKIKEVTVRGLEPEIQKL---IARHKQEVRRLKSLHEAELLQSDERASQR--CLR 747
EK K+ E +I L IA K ++ + + +A L + D+ +Q+ L+
Sbjct: 1061 --EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1118
Query: 748 QAEELREQLEREKEALGQQERERARQRFQQH-LEQEQWALQQQRQRLYSEVAEERERLGQ 806
+ EL + +E L + R + Q+ L +E AL+ + + A ++E
Sbjct: 1119 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL--- 1175
Query: 807 QAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAW 866
A++ E+ L++ L+E TR+ A+ + E ++H + L +QLE ++A
Sbjct: 1176 -RAKREQEVTVLKKALDEE----TRSHEAQVQ----EMRQKHAQAVEELTEQLEQFKRA- 1225
Query: 867 EAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRL 926
K + L +L E+R V+ + + ++ E +K E++++ L
Sbjct: 1226 -KANLDKNKQTLEKENADLAGELR---------VLGQAKQEV----EHKKKKLEAQVQEL 1271
Query: 927 RDKY---EAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVN 983
+ K E +EL KLQ + G L EAEG+ ++L V L+D Q +
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331
Query: 984 EQLSSERSNLAQVIRQEFEDRLAASE--EETRQAKAELATLQARQQLELEEVHRRVKTAL 1041
++ + ++ N++ +RQ E+R + + +E +AK L + ++L + ++++
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391
Query: 1042 A----------RKEEAVSSLRTQHEAAVKRADHLEE 1067
+ R ++ + +L Q+E D LE+
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Score = 104 bits (260), Expect = 4e-22
Identities = 196/865 (22%), Positives = 350/865 (40%), Gaps = 137/865 (15%)
Query: 292 RLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRA 351
+++ LLQ R+E+ ++ E L QK R++ E + ++ + Q ++K L+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDEL-----QKTKERQQKAENELKELEQKHSQLTEEKNLLQE 901
Query: 352 QKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGP--GDR 409
Q + E R+ +Q +E+ + + G L A +
Sbjct: 902 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE---EDRGQQLQAERKKMAQQ 958
Query: 410 CLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLE-----MMAPSRGSAKSRGPLEELLH-- 462
L + E + + + + +A LE M + +K R LEE +
Sbjct: 959 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018
Query: 463 TLQLLEKEPDV--LPRPRTHHRGRYAWASEEDDASSLTADNLEKF-----GKLSAFPEPP 515
T L E+E L + + H + + LEK G S F E
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 516 ED----------GTLLSEAKLQSIMSFLDE------------MEKSG-----QDQLDSQQ 548
D E +LQ+ ++ LD+ E G Q+ LDS++
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 549 EGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKET--- 605
+A +LG E+ LK E+E+ + A Q++L A+R +E
Sbjct: 1139 AAR-NKAEKQKRDLGEELEA----LKTELEDTLDST-------ATQQELRAKREQEVTVL 1186
Query: 606 EKALSRQLQRQREHYEATIQRHLAFIDQLIE--------------DKKVLSEKCEAVVAE 651
+KAL + + + Q+H +++L E +K+ L ++ + E
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 652 LKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEV--TVRGLE 709
L+ Q + V + + E ++++L+ S E+AR E +++K K++ +V G+
Sbjct: 1247 LRVLGQ-AKQEVEHKKKKLEAQVQELQSKCSDGERARAE--LNDKVHKLQNEVESVTGML 1303
Query: 710 PEIQKLIARHKQEVRRLKSLHE--AELLQSDERASQRCLRQAEELREQLEREKEALGQQ- 766
E + + ++V L S + ELLQ + R L + +LR QLE E+ +L Q
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK---LNVSTKLR-QLEEERNSLQDQL 1359
Query: 767 -ERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEES 825
E A+Q ++H+ L +++L + A E L + R + E+E L QQ EE
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKL-QDFASTVEALEEGKKRFQKEIENLTQQYEEK 1418
Query: 826 SSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQ-AWEAGRTRKEEAWLLNREQE 884
++A + E+ + R Q EL+ L L+ +RQ + +++ LL E+
Sbjct: 1419 AAAYDKL---------EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 885 LREEIRKGRDK-EIE--------LVIHRLEADMALAKEESE------KAAESRIKRLRDK 929
+ + RD+ E E L + R + AKEE E KA + +D
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529
Query: 930 YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSE 989
+ ELE+S+R L+ + E+K QL E E E +A EDA+ E
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQLEELEDEL-----------QATEDAKLRLEV---- 1574
Query: 990 RSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVS 1049
N+ Q ++ +FE L A +E+ + + +L + ELE+ ++ A A K++
Sbjct: 1575 --NM-QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 1050 SLRTQHEAAVKRADHLEELLEQHRR 1074
L+ A EE ++Q R+
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRK 1656
Score = 100 bits (249), Expect = 7e-21
Identities = 198/885 (22%), Positives = 370/885 (41%), Gaps = 162/885 (18%)
Query: 250 LPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG---AGAARLEHLLQAKREEQRQ 306
L + K E +A F Q+ I ++ A ARL+ + K ++
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 307 -RSGEGTLLDLHQQ---KEAARRKAREEKAR-----QARRAAIQEL-------QQKRALR 350
R EG + DL + + AAR KA ++K +A + +++ Q+ RA R
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 351 AQKASTAERGPPENPR--ETRVPGMRQP--------AQELSPTPGGTAH-----QALKAN 395
Q+ + ++ E R E +V MRQ ++L A+ Q L+
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 396 NT--GGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKS 453
N G L G + +Q E + + + AQ E+ + ++
Sbjct: 1240 NADLAGELRVLG-------------QAKQEVEHKKKKLEAQVQ-----ELQSKCSDGERA 1281
Query: 454 RGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPE 513
R L + +H LQ E + + G+ A L D +L E
Sbjct: 1282 RAELNDKVHKLQ---NEVESVTGMLNEAEGK---------AIKLAKDVASLSSQLQDTQE 1329
Query: 514 PPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRL 573
++ T + + + + L+E S QDQLD + E + E S + +
Sbjct: 1330 LLQEETR-QKLNVSTKLRQLEEERNSLQDQLDEEMEA----------KQNLERHISTLNI 1378
Query: 574 KLEVEEKK-QAMLLLQRALAQQRDLTARRVK------ETEKALSRQLQRQREHYEATIQR 626
+L +KK Q AL + + + ++ E + A +L++ + + +
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 627 HLAFID---QLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSA 683
+ +D QL+ + + K + ++AE K + + +A+A+ + K L A
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 684 TEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQ 743
E+A K E+T K+ L+ E++ L++ K +V K++HE E S+
Sbjct: 1499 LEEALEAKEELERTNKM-------LKAEMEDLVSS-KDDVG--KNVHELE-------KSK 1541
Query: 744 RCLR-QAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERE 802
R L Q EE++ QLE ++ L Q E A+ R + +++ + ++ Q + E+R
Sbjct: 1542 RALETQMEEMKTQLEELEDEL--QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1599
Query: 803 RLGQQAARQRAELEELRQQLEESSSALTRA--------LRAEFE-KGREEQERRHQMELN 853
+L +Q ELE+ R+Q +++A + L+A+ KGREE + +L
Sbjct: 1600 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK----QLR 1655
Query: 854 TLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKE 913
L+ Q++ ++ E R ++E + +E E + K +E + +L+ D+A A E
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKA-------KSLEADLMQLQEDLAAA-E 1707
Query: 914 ESEKAAESRIKRLRDKYEAELS---ELEQSERKLQERCSELKGQLGEAEGENLRLQGLVR 970
+ K A+ + L ++ + LS L+ +R+L+ R ++L+ +L E +G + VR
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 971 QKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLEL 1030
+A + A+ ++ +L++ERS A + E+ ARQQLE
Sbjct: 1768 ---KATQQAEQLSNELATERST--------------AQKNES-----------ARQQLER 1799
Query: 1031 EEVHRRVKTALARKEEAVSSLRTQHEAAVK-RADHLEELLEQHRR 1074
+ ++ +++ L E AV S AA++ + LEE +EQ R
Sbjct: 1800 Q--NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Score = 95.1 bits (235), Expect = 3e-19
Identities = 155/617 (25%), Positives = 265/617 (42%), Gaps = 124/617 (20%)
Query: 421 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQL-LEKEPDVLPRPRT 479
Q+ E+ TQ + AA D LE K++ L++ L L + L+ + ++
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLE---------KTKNRLQQELDDLVVDLDNQRQLVSNLEK 1455
Query: 480 HHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKS 539
R +EE + SS AD ++ A E L L+ + +E+E++
Sbjct: 1456 KQRKFDQLLAEEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERT 1512
Query: 540 GQDQLDSQQEGWVP---EAGPGPLELGS----------EVSTSVMRLKLEVEEKKQAMLL 586
+ L ++ E V + G EL E+ T + L+ E++ + A L
Sbjct: 1513 NK-MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571
Query: 587 LQ---RALAQQ--RDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVL 641
L+ +AL Q RDL AR + EK RQLQRQ YE + ED++
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKR--RQLQRQLHEYETEL-----------EDER-- 1616
Query: 642 SEKCEAVVAELKQE-DQRCTERVAQAQAQ-HELEIKKLKELMSATEKARREKWISEKTKK 699
++ A A+ K E D + E A + + E IK+L++L + + +RE + ++
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR- 1675
Query: 700 IKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLERE 759
++ A K+ ++ KSL EA+L+Q E L AE R+Q + E
Sbjct: 1676 -------------DEIFATAKENEKKAKSL-EADLMQLQED-----LAAAERARKQADLE 1716
Query: 760 KEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELR 819
KE L ++ R ALQ +++RL + +A+ E L ++ A + +R
Sbjct: 1717 KEELAEELASSLSGRN---------ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 820 ---QQLEESSSALT--RALRAEFEKGREEQERR--------HQMELNTLKQQLELERQAW 866
QQ E+ S+ L R+ + E R++ ER+ H+ME +K + + A
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME-GAVKSKFKSTIAAL 1826
Query: 867 EAGRTRKEEAWLLNREQELREEIR-----KGRDKEIELVIHRLEADMALAKEESEKAAES 921
EA + EE EQE RE+ K +DK+++ ++ ++E + +A++ E+A
Sbjct: 1827 EAKIAQLEE----QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA--- 1879
Query: 922 RIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQA 981
K R +LK QL EAE E+ R+ R+ +R L++A
Sbjct: 1880 --------------------EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1919
Query: 982 VNEQLSSERSNLAQVIR 998
NE + E + L +R
Sbjct: 1920 SNEAMGREVNALKSKLR 1936
Score = 89.0 bits (219), Expect = 2e-17
Identities = 167/784 (21%), Positives = 337/784 (42%), Gaps = 101/784 (12%)
Query: 297 LQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQEL-QQKRALRAQKAS 355
L+AKRE+ E T+L +E +A+ ++ RQ A++EL +Q + KA+
Sbjct: 1175 LRAKREQ------EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN 1228
Query: 356 ------TAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDR 409
T E+ + E RV G + E Q L++ + G A D+
Sbjct: 1229 LDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1288
Query: 410 C--LPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLL 467
L S + LA+D A + ++ + + L+ L
Sbjct: 1289 VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1348
Query: 468 EKEPDVLPRPRTHHRGRYAWASEEDDASSLT---ADNLEKFGKLSAFPEPPEDGTLLSEA 524
E+E + L A + E S+L +D+ +K ++ E E+G +
Sbjct: 1349 EEERNSLQDQLDEEME--AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406
Query: 525 KLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAM 584
+++++ +E + + D+L+ + E ++L ++ R + EKKQ
Sbjct: 1407 EIENLTQQYEE-KAAAYDKLEKTKNRLQQELDDLVVDLDNQ------RQLVSNLEKKQRK 1459
Query: 585 LLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEK 644
+ LA++++++++ E ++A + R++E ++ R L ++ +E K+ L
Sbjct: 1460 F--DQLLAEEKNISSKYADERDRAEAEA--REKETKALSLARAL---EEALEAKEELERT 1512
Query: 645 CEAVVAELKQEDQRCTERVAQAQAQHELEIKK------LKELMSATEKARREKWISEKTK 698
+ + AE+ + + + + HELE K ++E+ + E+ E +E K
Sbjct: 1513 NKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 699 KIKEVTVRGLEPEIQK-LIARHKQ--EVRRL--KSLHEAELLQSDERASQRCLRQAEELR 753
EV ++ L+ + ++ L AR +Q E RR + LHE E DER + A++
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Query: 754 E------QLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQ 807
E +L+ + G++E + ++ Q ++ Q L+ R A +E
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN---- 1685
Query: 808 AARQRAELEELRQQLEESSSALTRALR-AEFEK------------GR---EEQERRHQME 851
++ LE QL+E +A RA + A+ EK GR ++++RR +
Sbjct: 1686 -EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1744
Query: 852 LNTLKQQLELERQAWEA--GRTRK--EEAWLLNRE-----------QELREEIRKGRDKE 896
+ L+++LE E+ EA R RK ++A L+ E + R+++ + ++KE
Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER-QNKE 1803
Query: 897 IELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLG 956
+ +H +E + + + A E++I +L ++ E E E + + + L+++ +LK L
Sbjct: 1804 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863
Query: 957 EAEGENLRLQ----------GLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLA 1006
+ E E + V+Q +R LE+A+ ++++++ R L + + + E A
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1923
Query: 1007 ASEE 1010
E
Sbjct: 1924 MGRE 1927
Score = 85.9 bits (211), Expect = 2e-16
Identities = 108/449 (24%), Positives = 195/449 (43%), Gaps = 70/449 (15%)
Query: 662 RVAQAQAQHELE-IKKLKELMSATEKARREKW--ISEKTKKIKEVT-----VRGLEPEIQ 713
R A A+ Q +L +K ++ +A K R +W + K K + +VT ++ E E+Q
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 869
Query: 714 KLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQ 773
K R ++ LK L + ++E+ L+EQL+ E E + E R R
Sbjct: 870 KTKERQQKAENELKELEQKHSQLTEEK---------NLLQEQLQAETELYAEAEEMRVRL 920
Query: 774 RFQ-QHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRA 832
+ Q LE+ L + RL EE E GQQ +R ++ + LEE
Sbjct: 921 AAKKQELEE---ILHEMEARL-----EEEEDRGQQLQAERKKMAQQMLDLEEQLE----- 967
Query: 833 LRAEFEKGREEQERRHQMELNTLKQQLELERQAWEA-------GRTRKEEAWLLNREQEL 885
EE+ R +++L + + ++++ E + KE L R +L
Sbjct: 968 ---------EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018
Query: 886 REEIRKGRDKEIELVIHRLEADMALAKEE----SEKAAESRIKRLRDKYEAELSELEQSE 941
+ + +K L + + + +++ E E+ + +++L+ K E + S+ +
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 942 RKLQERCSELKGQLGEAEGE----NLRLQGLVRQKERALEDAQA-------VNEQLSSER 990
LQ + +ELK QL + E E RL + QK AL+ + + E L SER
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 991 S--NLAQVIRQEFEDRLAASE---EETRQAKAELATLQARQQLELEEVHRRVKTALARKE 1045
+ N A+ +++ + L A + E+T + A L+A+++ E+ + + + E
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198
Query: 1046 EAVSSLRTQHEAAVKRADHLEELLEQHRR 1074
V +R +H AV + L E LEQ +R
Sbjct: 1199 AQVQEMRQKHAQAV---EELTEQLEQFKR 1224
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.124 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,350,725
Number of Sequences: 37866
Number of extensions: 2319309
Number of successful extensions: 38261
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 548
Number of HSP's successfully gapped in prelim test: 1605
Number of HSP's that attempted gapping in prelim test: 12613
Number of HSP's gapped (non-prelim): 10457
length of query: 1080
length of database: 18,247,518
effective HSP length: 113
effective length of query: 967
effective length of database: 13,968,660
effective search space: 13507694220
effective search space used: 13507694220
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.