BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|111154084 pleckstrin homology domain containing family G member 5 isoform b [Homo sapiens] (1083 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|111154084 pleckstrin homology domain containing family G memb... 2184 0.0 gi|111154078 pleckstrin homology domain containing family G memb... 2138 0.0 gi|38373682 pleckstrin homology domain containing family G membe... 2017 0.0 gi|111154088 pleckstrin homology domain containing family G memb... 2017 0.0 gi|111154080 pleckstrin homology domain containing family G memb... 2017 0.0 gi|222080070 pleckstrin homology domain-containing family G memb... 421 e-117 gi|222080068 pleckstrin homology domain-containing family G memb... 421 e-117 gi|222080066 pleckstrin homology domain-containing family G memb... 421 e-117 gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 145 2e-34 gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 136 9e-32 gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 136 9e-32 gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 136 9e-32 gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 132 2e-30 gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 132 2e-30 gi|51972240 pleckstrin homology domain containing, family G (wit... 101 4e-21 gi|194473700 Src homology 3 domain-containing guanine nucleotide... 99 2e-20 gi|163792208 Rho guanine exchange factor 16 [Homo sapiens] 85 4e-16 gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 83 1e-15 gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 83 1e-15 gi|166197690 neuronal guanine nucleotide exchange factor isoform... 82 3e-15 gi|166197688 neuronal guanine nucleotide exchange factor isoform... 82 3e-15 gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 80 1e-14 gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens] 79 3e-14 gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens] 79 3e-14 gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens] 79 3e-14 gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Hom... 78 4e-14 gi|32307166 Rho guanine exchange factor 15 [Homo sapiens] 77 7e-14 gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ... 77 9e-14 gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor... 73 2e-12 gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor... 73 2e-12 >gi|111154084 pleckstrin homology domain containing family G member 5 isoform b [Homo sapiens] Length = 1083 Score = 2184 bits (5660), Expect = 0.0 Identities = 1083/1083 (100%), Positives = 1083/1083 (100%) Query: 1 MNSVLTKHGSPPRSWLSLCSGTDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHR 60 MNSVLTKHGSPPRSWLSLCSGTDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHR Sbjct: 1 MNSVLTKHGSPPRSWLSLCSGTDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHR 60 Query: 61 RGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEE 120 RGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEE Sbjct: 61 RGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEE 120 Query: 121 SSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEV 180 SSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEV Sbjct: 121 SSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEV 180 Query: 181 LLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKD 240 LLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKD Sbjct: 181 LLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKD 240 Query: 241 SKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTP 300 SKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTP Sbjct: 241 SKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTP 300 Query: 301 SSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLF 360 SSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLF Sbjct: 301 SSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLF 360 Query: 361 GLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWE 420 GLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWE Sbjct: 361 GLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWE 420 Query: 421 LLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMA 480 LLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMA Sbjct: 421 LLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMA 480 Query: 481 PVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYI 540 PVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYI Sbjct: 481 PVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYI 540 Query: 541 TWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIH 600 TWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIH Sbjct: 541 TWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIH 600 Query: 601 HVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETR 660 HVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETR Sbjct: 601 HVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETR 660 Query: 661 QLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRD 720 QLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRD Sbjct: 661 QLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRD 720 Query: 721 PGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQS 780 PGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQS Sbjct: 721 PGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQS 780 Query: 781 LEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVV 840 LEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVV Sbjct: 781 LEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVV 840 Query: 841 VEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLS 900 VEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLS Sbjct: 841 VEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLS 900 Query: 901 PTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLL 960 PTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLL Sbjct: 901 PTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLL 960 Query: 961 QLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVG 1020 QLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVG Sbjct: 961 QLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVG 1020 Query: 1021 CLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTA 1080 CLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTA Sbjct: 1021 CLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTA 1080 Query: 1081 SEV 1083 SEV Sbjct: 1081 SEV 1083 >gi|111154078 pleckstrin homology domain containing family G member 5 isoform c [Homo sapiens] Length = 1062 Score = 2138 bits (5539), Expect = 0.0 Identities = 1061/1061 (100%), Positives = 1061/1061 (100%) Query: 23 DDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDG 82 DDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDG Sbjct: 2 DDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDG 61 Query: 83 HVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKAR 142 HVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKAR Sbjct: 62 HVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKAR 121 Query: 143 RRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQS 202 RRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQS Sbjct: 122 RRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQS 181 Query: 203 NTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERV 262 NTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERV Sbjct: 182 NTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERV 241 Query: 263 DAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNR 322 DAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNR Sbjct: 242 DAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNR 301 Query: 323 AASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDE 382 AASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDE Sbjct: 302 AASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDE 361 Query: 383 DEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCC 442 DEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCC Sbjct: 362 DEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCC 421 Query: 443 LLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGF 502 LLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGF Sbjct: 422 LLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGF 481 Query: 503 KMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPH 562 KMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPH Sbjct: 482 KMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPH 541 Query: 563 QRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRI 622 QRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRI Sbjct: 542 QRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRI 601 Query: 623 DAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYC 682 DAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYC Sbjct: 602 DAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYC 661 Query: 683 FLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQ 742 FLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQ Sbjct: 662 FLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQ 721 Query: 743 ASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGE 802 ASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGE Sbjct: 722 ASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGE 781 Query: 803 DSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSD 862 DSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSD Sbjct: 782 DSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSD 841 Query: 863 ETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPE 922 ETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPE Sbjct: 842 ETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPE 901 Query: 923 SPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSEL 982 SPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSEL Sbjct: 902 SPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSEL 961 Query: 983 CLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGAS 1042 CLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGAS Sbjct: 962 CLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGAS 1021 Query: 1043 PRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1083 PRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV Sbjct: 1022 PRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1062 >gi|38373682 pleckstrin homology domain containing family G member 5 isoform a [Homo sapiens] Length = 1006 Score = 2017 bits (5225), Expect = 0.0 Identities = 1006/1006 (100%), Positives = 1006/1006 (100%) Query: 78 MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS 137 MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS Sbjct: 1 MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS 60 Query: 138 KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI 197 KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI Sbjct: 61 KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI 120 Query: 198 YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP 257 YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP Sbjct: 121 YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP 180 Query: 258 ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD 317 ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD Sbjct: 181 ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD 240 Query: 318 SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE 377 SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE Sbjct: 241 SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE 300 Query: 378 EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN 437 EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN Sbjct: 301 EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN 360 Query: 438 LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 497 LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD Sbjct: 361 LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 420 Query: 498 FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM 557 FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM Sbjct: 421 FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM 480 Query: 558 LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA 617 LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA Sbjct: 481 LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA 540 Query: 618 VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK 677 VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK Sbjct: 541 VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK 600 Query: 678 MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG 737 MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG Sbjct: 601 MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG 660 Query: 738 AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE 797 AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE Sbjct: 661 AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE 720 Query: 798 EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF 857 EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF Sbjct: 721 EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF 780 Query: 858 SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV 917 SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV Sbjct: 781 SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV 840 Query: 918 PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR 977 PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR Sbjct: 841 PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR 900 Query: 978 SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL 1037 SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL Sbjct: 901 SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL 960 Query: 1038 PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1083 PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV Sbjct: 961 PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1006 >gi|111154088 pleckstrin homology domain containing family G member 5 isoform a [Homo sapiens] Length = 1006 Score = 2017 bits (5225), Expect = 0.0 Identities = 1006/1006 (100%), Positives = 1006/1006 (100%) Query: 78 MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS 137 MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS Sbjct: 1 MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS 60 Query: 138 KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI 197 KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI Sbjct: 61 KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI 120 Query: 198 YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP 257 YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP Sbjct: 121 YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP 180 Query: 258 ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD 317 ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD Sbjct: 181 ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD 240 Query: 318 SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE 377 SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE Sbjct: 241 SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE 300 Query: 378 EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN 437 EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN Sbjct: 301 EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN 360 Query: 438 LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 497 LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD Sbjct: 361 LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 420 Query: 498 FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM 557 FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM Sbjct: 421 FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM 480 Query: 558 LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA 617 LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA Sbjct: 481 LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA 540 Query: 618 VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK 677 VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK Sbjct: 541 VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK 600 Query: 678 MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG 737 MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG Sbjct: 601 MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG 660 Query: 738 AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE 797 AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE Sbjct: 661 AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE 720 Query: 798 EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF 857 EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF Sbjct: 721 EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF 780 Query: 858 SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV 917 SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV Sbjct: 781 SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV 840 Query: 918 PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR 977 PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR Sbjct: 841 PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR 900 Query: 978 SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL 1037 SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL Sbjct: 901 SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL 960 Query: 1038 PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1083 PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV Sbjct: 961 PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1006 >gi|111154080 pleckstrin homology domain containing family G member 5 isoform a [Homo sapiens] Length = 1006 Score = 2017 bits (5225), Expect = 0.0 Identities = 1006/1006 (100%), Positives = 1006/1006 (100%) Query: 78 MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS 137 MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS Sbjct: 1 MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS 60 Query: 138 KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI 197 KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI Sbjct: 61 KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI 120 Query: 198 YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP 257 YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP Sbjct: 121 YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP 180 Query: 258 ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD 317 ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD Sbjct: 181 ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD 240 Query: 318 SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE 377 SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE Sbjct: 241 SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE 300 Query: 378 EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN 437 EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN Sbjct: 301 EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN 360 Query: 438 LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 497 LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD Sbjct: 361 LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 420 Query: 498 FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM 557 FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM Sbjct: 421 FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM 480 Query: 558 LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA 617 LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA Sbjct: 481 LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA 540 Query: 618 VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK 677 VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK Sbjct: 541 VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK 600 Query: 678 MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG 737 MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG Sbjct: 601 MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG 660 Query: 738 AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE 797 AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE Sbjct: 661 AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE 720 Query: 798 EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF 857 EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF Sbjct: 721 EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF 780 Query: 858 SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV 917 SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV Sbjct: 781 SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV 840 Query: 918 PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR 977 PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR Sbjct: 841 PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR 900 Query: 978 SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL 1037 SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL Sbjct: 901 SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL 960 Query: 1038 PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1083 PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV Sbjct: 961 PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1006 >gi|222080070 pleckstrin homology domain-containing family G member 6 isoform b [Homo sapiens] Length = 758 Score = 421 bits (1083), Expect = e-117 Identities = 282/767 (36%), Positives = 407/767 (53%), Gaps = 67/767 (8%) Query: 326 RFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDED 385 R G +G S +E+ K +LE +LHT+S+FG+PRLP D WE D Sbjct: 50 RHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPE---DRRHWEIGEGGDSG 106 Query: 386 EDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLN 445 L +E SWREL+ GH+++++ CHQQEA+WELL TE Y+RKL+++ +L LLN Sbjct: 107 -----LTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLN 161 Query: 446 LQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMF 505 LQ GLL EV AE LF N+P + + HR W V+ P LE+ R + L P GF F Sbjct: 162 LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTF 221 Query: 506 GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 565 G F PY++YC+ + M Y R N LF A++ W EKH + R L D+L KPHQR+ Sbjct: 222 GQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI 281 Query: 566 TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAY 625 TKYPLLL +VL+++ E RA+EA+ AMI +VE F+ H+N +RQ +E++ LAA RI Y Sbjct: 282 TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPY 341 Query: 626 EVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLF 685 EV+E SDEV+K L+ F LDLT+P+ G + E TRQLLLEG +R+KEG++ K+DVY FLF Sbjct: 342 EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLF 401 Query: 686 TDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASG 745 +D+LLVTK +KA++ +VIRPPL+++K+VC+ LRDP SFLLI+L EF A Sbjct: 402 SDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPS 461 Query: 746 QALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSG 805 W++ AQ LQ+L+A+E ++ L +L ++D + Sbjct: 462 PTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRE----------------- 504 Query: 806 TSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETS 865 SP+ R S+ S + +++G T + ++ P ++ + P S Sbjct: 505 -----SPS-TRPSTPSLEGSQSSAEGRTPEFSTII--PHLVVTEDTDEDAPLVPDDTSDS 556 Query: 866 LSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF-VAPGPMAELVPRAPESP 924 T TPT PL + R+ D T S L+D + P P P+AP+ Sbjct: 557 GYGTLIPGTPTGSRSPLSRLRQRALRRDPRL-TFSTLELRDIPLRPHPPD---PQAPQRR 612 Query: 925 RVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS-----LLQLLAGAGTHG-TPSAPSRS 978 P P P + PP + + AS +++ L A G PS+P+ + Sbjct: 613 SAPELPEGILKGGSLPQE---DPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHA 669 Query: 979 LSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLP 1038 S A +P + G +E GP + G S L A + R+ Sbjct: 670 DS----AGESPW-ESSGEEEEEGPLFLKAGHTS------LRPMRAEDMLREIREEL---- 714 Query: 1039 SGASPRVQPEPPPGVSAQHRKLTLAQLYRIR--TTLLLNSTLTASEV 1083 AS R++ P ++ RKLT AQL R+R + L++ L+ASEV Sbjct: 715 --ASQRIEGAEEPR-DSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 758 >gi|222080068 pleckstrin homology domain-containing family G member 6 isoform a [Homo sapiens] Length = 790 Score = 421 bits (1083), Expect = e-117 Identities = 282/767 (36%), Positives = 407/767 (53%), Gaps = 67/767 (8%) Query: 326 RFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDED 385 R G +G S +E+ K +LE +LHT+S+FG+PRLP D WE D Sbjct: 82 RHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPE---DRRHWEIGEGGDSG 138 Query: 386 EDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLN 445 L +E SWREL+ GH+++++ CHQQEA+WELL TE Y+RKL+++ +L LLN Sbjct: 139 -----LTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLN 193 Query: 446 LQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMF 505 LQ GLL EV AE LF N+P + + HR W V+ P LE+ R + L P GF F Sbjct: 194 LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTF 253 Query: 506 GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 565 G F PY++YC+ + M Y R N LF A++ W EKH + R L D+L KPHQR+ Sbjct: 254 GQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI 313 Query: 566 TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAY 625 TKYPLLL +VL+++ E RA+EA+ AMI +VE F+ H+N +RQ +E++ LAA RI Y Sbjct: 314 TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPY 373 Query: 626 EVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLF 685 EV+E SDEV+K L+ F LDLT+P+ G + E TRQLLLEG +R+KEG++ K+DVY FLF Sbjct: 374 EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLF 433 Query: 686 TDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASG 745 +D+LLVTK +KA++ +VIRPPL+++K+VC+ LRDP SFLLI+L EF A Sbjct: 434 SDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPS 493 Query: 746 QALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSG 805 W++ AQ LQ+L+A+E ++ L +L ++D + Sbjct: 494 PTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRE----------------- 536 Query: 806 TSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETS 865 SP+ R S+ S + +++G T + ++ P ++ + P S Sbjct: 537 -----SPS-TRPSTPSLEGSQSSAEGRTPEFSTII--PHLVVTEDTDEDAPLVPDDTSDS 588 Query: 866 LSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF-VAPGPMAELVPRAPESP 924 T TPT PL + R+ D T S L+D + P P P+AP+ Sbjct: 589 GYGTLIPGTPTGSRSPLSRLRQRALRRDPRL-TFSTLELRDIPLRPHPPD---PQAPQRR 644 Query: 925 RVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS-----LLQLLAGAGTHG-TPSAPSRS 978 P P P + PP + + AS +++ L A G PS+P+ + Sbjct: 645 SAPELPEGILKGGSLPQE---DPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHA 701 Query: 979 LSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLP 1038 S A +P + G +E GP + G S L A + R+ Sbjct: 702 DS----AGESPW-ESSGEEEEEGPLFLKAGHTS------LRPMRAEDMLREIREEL---- 746 Query: 1039 SGASPRVQPEPPPGVSAQHRKLTLAQLYRIR--TTLLLNSTLTASEV 1083 AS R++ P ++ RKLT AQL R+R + L++ L+ASEV Sbjct: 747 --ASQRIEGAEEPR-DSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 790 >gi|222080066 pleckstrin homology domain-containing family G member 6 isoform a [Homo sapiens] Length = 790 Score = 421 bits (1083), Expect = e-117 Identities = 282/767 (36%), Positives = 407/767 (53%), Gaps = 67/767 (8%) Query: 326 RFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDED 385 R G +G S +E+ K +LE +LHT+S+FG+PRLP D WE D Sbjct: 82 RHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPE---DRRHWEIGEGGDSG 138 Query: 386 EDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLN 445 L +E SWREL+ GH+++++ CHQQEA+WELL TE Y+RKL+++ +L LLN Sbjct: 139 -----LTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLN 193 Query: 446 LQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMF 505 LQ GLL EV AE LF N+P + + HR W V+ P LE+ R + L P GF F Sbjct: 194 LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTF 253 Query: 506 GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 565 G F PY++YC+ + M Y R N LF A++ W EKH + R L D+L KPHQR+ Sbjct: 254 GQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI 313 Query: 566 TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAY 625 TKYPLLL +VL+++ E RA+EA+ AMI +VE F+ H+N +RQ +E++ LAA RI Y Sbjct: 314 TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPY 373 Query: 626 EVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLF 685 EV+E SDEV+K L+ F LDLT+P+ G + E TRQLLLEG +R+KEG++ K+DVY FLF Sbjct: 374 EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLF 433 Query: 686 TDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASG 745 +D+LLVTK +KA++ +VIRPPL+++K+VC+ LRDP SFLLI+L EF A Sbjct: 434 SDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPS 493 Query: 746 QALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSG 805 W++ AQ LQ+L+A+E ++ L +L ++D + Sbjct: 494 PTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRE----------------- 536 Query: 806 TSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETS 865 SP+ R S+ S + +++G T + ++ P ++ + P S Sbjct: 537 -----SPS-TRPSTPSLEGSQSSAEGRTPEFSTII--PHLVVTEDTDEDAPLVPDDTSDS 588 Query: 866 LSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF-VAPGPMAELVPRAPESP 924 T TPT PL + R+ D T S L+D + P P P+AP+ Sbjct: 589 GYGTLIPGTPTGSRSPLSRLRQRALRRDPRL-TFSTLELRDIPLRPHPPD---PQAPQRR 644 Query: 925 RVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS-----LLQLLAGAGTHG-TPSAPSRS 978 P P P + PP + + AS +++ L A G PS+P+ + Sbjct: 645 SAPELPEGILKGGSLPQE---DPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHA 701 Query: 979 LSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLP 1038 S A +P + G +E GP + G S L A + R+ Sbjct: 702 DS----AGESPW-ESSGEEEEEGPLFLKAGHTS------LRPMRAEDMLREIREEL---- 746 Query: 1039 SGASPRVQPEPPPGVSAQHRKLTLAQLYRIR--TTLLLNSTLTASEV 1083 AS R++ P ++ RKLT AQL R+R + L++ L+ASEV Sbjct: 747 --ASQRIEGAEEPR-DSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 790 >gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo sapiens] Length = 1544 Score = 145 bits (367), Expect = 2e-34 Identities = 159/673 (23%), Positives = 287/673 (42%), Gaps = 80/673 (11%) Query: 217 GHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALER-VDAQSRRESLDILA 275 G ++K K EG+ + + S+ P RP+ A+ R ++ Q R + Sbjct: 573 GFLPKIKQSMKKDKEGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAMELQKARHPKHLST 632 Query: 276 PGR--------RRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRF 327 P + S E + G P S S+ SG+S S G +N S+ Sbjct: 633 PSSVSPEPQDSAKLRQSGLANEGTDAGYLPANSMS-SVASGASFSQEGGK--ENDTGSKQ 689 Query: 328 SGFFSSGPSTSAFGRE-------------VDKMEQLEGKLHTYSLFGLPRLPRGLRFDHD 374 G +S P + G +D++++ E ++ + G P+ R +FD Sbjct: 690 VGE-TSAPGDTLDGTPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFR--KFDSV 746 Query: 375 SWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCH--QQEAVWELLHTEASYIRKL 432 ++ E EDE +N +W++L+ L + C +QE + EL +TE +++R L Sbjct: 747 AFGESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTL 806 Query: 433 RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 492 +V+ +F + G+L E ++FSN+ +I QLH L + A + K T + Sbjct: 807 KVLDQVFY---QRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKA--VRKRNETSVI 861 Query: 493 LQPG-DFLKGFKMFGS--LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQC 549 Q G D L F G L +C + +E ++ + + F+ ++ AE +P C Sbjct: 862 DQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLC 921 Query: 550 QRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQR 609 +RL+L D++ QRLTKYPLLL ++ + TE P +E V + +++VN +++ Sbjct: 922 RRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEA 981 Query: 610 QERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLR 669 + +QRL R+D + S V+ E +LDLT R+++ EG L Sbjct: 982 ENKQRLEDYQRRLDTSSLKLSEYPNVE----ELRNLDLT----------KRKMIHEGPLV 1027 Query: 670 MKEGKDSKMDVYCFLFTDLLLVTK--------------AVKKAERTRVIRPPLLVDKIVC 715 K +D +D+Y L D+L++ + A+ P + + ++ Sbjct: 1028 WKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLV 1087 Query: 716 RELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQ 775 R++ L + S GA ++ Q + T++ Q+ + ++ A S Sbjct: 1088 RQVATDNKALFVI---SMSDNGAQIYELVAQTVSE---KTVW--QDLICRMAASVKEQST 1139 Query: 776 QPL---QSLEEEEDEQEEEEEEEEEEEEG-EDSGTSAASSPTIMRKS--SGSPDSQHCAS 829 +P+ QS E D EE+ + +EE+ G +G + + + S P S ++ Sbjct: 1140 KPIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLST 1199 Query: 830 DGSTETLAMVVVE 842 G +E + V E Sbjct: 1200 SGKSEVRDLFVAE 1212 >gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [Homo sapiens] Length = 927 Score = 136 bits (343), Expect = 9e-32 Identities = 123/437 (28%), Positives = 200/437 (45%), Gaps = 63/437 (14%) Query: 397 WRELI--DGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFL-----CCLLNLQES 449 WREL+ D L + Q +QE + ELL TEA+++R LRV+ +LF C L+E Sbjct: 413 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEE- 471 Query: 450 GLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALL--QPGDFL--KGFKMF 505 + +F ++ E+ ++H S+ L K R+ L + GD L + Sbjct: 472 -------LQNIFPSLDELIEVH-----SLFLDRLMKRRQESGYLIEEIGDVLLARFDGAE 519 Query: 506 GSLF-KPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQR 564 GS F K R+C + +E ++ R + F A++ AE P+C+RL+L DM+ QR Sbjct: 520 GSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQR 579 Query: 565 LTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDA 624 LTKYPLLL+S+ + TEEP +E V +HHVN +R ++ RL R+D Sbjct: 580 LTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 639 Query: 625 YEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFL 684 + +SS D +L EF +LD+T ++L+ EG L + KD ++V+ L Sbjct: 640 SHLRQSS----DPMLSEFKNLDIT----------KKKLVHEGPLTWRVTKDKAVEVHVLL 685 Query: 685 FTDLLLVTK------AVKKAERT--------RVIRPPLLVDKIVCREL-RDPGSFLLIYL 729 DLLL+ + +K RT ++RP L + + RE+ D +F +++ Sbjct: 686 LDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 745 Query: 730 NEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQL-------QQLRAQEPPGSQQPLQSLE 782 + + + Y A + + W I L + P +++PL S Sbjct: 746 WDQEAQI--YELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSS 803 Query: 783 EEEDEQEEEEEEEEEEE 799 E + E + E Sbjct: 804 ENGNGGRETSPADARTE 820 >gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [Homo sapiens] Length = 879 Score = 136 bits (343), Expect = 9e-32 Identities = 123/437 (28%), Positives = 200/437 (45%), Gaps = 63/437 (14%) Query: 397 WRELI--DGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFL-----CCLLNLQES 449 WREL+ D L + Q +QE + ELL TEA+++R LRV+ +LF C L+E Sbjct: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEE- 423 Query: 450 GLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALL--QPGDFL--KGFKMF 505 + +F ++ E+ ++H S+ L K R+ L + GD L + Sbjct: 424 -------LQNIFPSLDELIEVH-----SLFLDRLMKRRQESGYLIEEIGDVLLARFDGAE 471 Query: 506 GSLF-KPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQR 564 GS F K R+C + +E ++ R + F A++ AE P+C+RL+L DM+ QR Sbjct: 472 GSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQR 531 Query: 565 LTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDA 624 LTKYPLLL+S+ + TEEP +E V +HHVN +R ++ RL R+D Sbjct: 532 LTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591 Query: 625 YEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFL 684 + +SS D +L EF +LD+T ++L+ EG L + KD ++V+ L Sbjct: 592 SHLRQSS----DPMLSEFKNLDIT----------KKKLVHEGPLTWRVTKDKAVEVHVLL 637 Query: 685 FTDLLLVTK------AVKKAERT--------RVIRPPLLVDKIVCREL-RDPGSFLLIYL 729 DLLL+ + +K RT ++RP L + + RE+ D +F +++ Sbjct: 638 LDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 697 Query: 730 NEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQL-------QQLRAQEPPGSQQPLQSLE 782 + + + Y A + + W I L + P +++PL S Sbjct: 698 WDQEAQI--YELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSS 755 Query: 783 EEEDEQEEEEEEEEEEE 799 E + E + E Sbjct: 756 ENGNGGRETSPADARTE 772 >gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [Homo sapiens] Length = 912 Score = 136 bits (343), Expect = 9e-32 Identities = 123/437 (28%), Positives = 200/437 (45%), Gaps = 63/437 (14%) Query: 397 WRELI--DGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFL-----CCLLNLQES 449 WREL+ D L + Q +QE + ELL TEA+++R LRV+ +LF C L+E Sbjct: 398 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEE- 456 Query: 450 GLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALL--QPGDFL--KGFKMF 505 + +F ++ E+ ++H S+ L K R+ L + GD L + Sbjct: 457 -------LQNIFPSLDELIEVH-----SLFLDRLMKRRQESGYLIEEIGDVLLARFDGAE 504 Query: 506 GSLF-KPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQR 564 GS F K R+C + +E ++ R + F A++ AE P+C+RL+L DM+ QR Sbjct: 505 GSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQR 564 Query: 565 LTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDA 624 LTKYPLLL+S+ + TEEP +E V +HHVN +R ++ RL R+D Sbjct: 565 LTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 624 Query: 625 YEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFL 684 + +SS D +L EF +LD+T ++L+ EG L + KD ++V+ L Sbjct: 625 SHLRQSS----DPMLSEFKNLDIT----------KKKLVHEGPLTWRVTKDKAVEVHVLL 670 Query: 685 FTDLLLVTK------AVKKAERT--------RVIRPPLLVDKIVCREL-RDPGSFLLIYL 729 DLLL+ + +K RT ++RP L + + RE+ D +F +++ Sbjct: 671 LDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 730 Query: 730 NEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQL-------QQLRAQEPPGSQQPLQSLE 782 + + + Y A + + W I L + P +++PL S Sbjct: 731 WDQEAQI--YELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSS 788 Query: 783 EEEDEQEEEEEEEEEEE 799 E + E + E Sbjct: 789 ENGNGGRETSPADARTE 805 >gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2 [Homo sapiens] Length = 1562 Score = 132 bits (331), Expect = 2e-30 Identities = 116/427 (27%), Positives = 198/427 (46%), Gaps = 55/427 (12%) Query: 407 LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 466 LT+R+ +QE + EL TEAS++R LRV+ +F +++ L+ E RLF N+PE Sbjct: 768 LTQREIDRQEVINELFVTEASHLRTLRVLDLIFY---QRMKKENLMPREELARLFPNLPE 824 Query: 467 IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFG----SLFKPYIRYCMEEEGC 522 + ++H W M +K R +++ L + G L + ++C + Sbjct: 825 LIEIHNS-WCEAM----KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIA 879 Query: 523 MEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEP 582 +E ++ R F+ ++ AE HPQC+RL+L D++ QRLTKYPLLL+S+++ TE Sbjct: 880 LELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGG 939 Query: 583 RAK-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKE 641 ++ E + + +VN ++Q + R RL R+DA + +S + L E Sbjct: 940 TSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERAS----NPLAAE 995 Query: 642 FLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK-------- 693 F LDLT TR+++ EG L + KD +D++ L DLL++ + Sbjct: 996 FKSLDLT----------TRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLL 1045 Query: 694 ------AVKKAERTRVIRPPLLVDKIVCREL-RDPGSFLLIYLNEFHSAVGAYTFQASGQ 746 AV ++ + P L ++ ++ R + D +F +I ++ Y A Sbjct: 1046 KCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL-GPPQIYELVALTS 1104 Query: 747 ALCRGWVDTIYNA-QNQLQQLRA------QEPPGSQQPLQ-----SLEEEEDEQEEEEEE 794 + W++ + A +N + A PPG ++P Q S E +D E Sbjct: 1105 SDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEP 1164 Query: 795 EEEEEEG 801 E EE G Sbjct: 1165 EPEELPG 1171 >gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1 [Homo sapiens] Length = 1522 Score = 132 bits (331), Expect = 2e-30 Identities = 116/427 (27%), Positives = 198/427 (46%), Gaps = 55/427 (12%) Query: 407 LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 466 LT+R+ +QE + EL TEAS++R LRV+ +F +++ L+ E RLF N+PE Sbjct: 728 LTQREIDRQEVINELFVTEASHLRTLRVLDLIFY---QRMKKENLMPREELARLFPNLPE 784 Query: 467 IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFG----SLFKPYIRYCMEEEGC 522 + ++H W M +K R +++ L + G L + ++C + Sbjct: 785 LIEIHNS-WCEAM----KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIA 839 Query: 523 MEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEP 582 +E ++ R F+ ++ AE HPQC+RL+L D++ QRLTKYPLLL+S+++ TE Sbjct: 840 LELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGG 899 Query: 583 RAK-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKE 641 ++ E + + +VN ++Q + R RL R+DA + +S + L E Sbjct: 900 TSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERAS----NPLAAE 955 Query: 642 FLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK-------- 693 F LDLT TR+++ EG L + KD +D++ L DLL++ + Sbjct: 956 FKSLDLT----------TRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLL 1005 Query: 694 ------AVKKAERTRVIRPPLLVDKIVCREL-RDPGSFLLIYLNEFHSAVGAYTFQASGQ 746 AV ++ + P L ++ ++ R + D +F +I ++ Y A Sbjct: 1006 KCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL-GPPQIYELVALTS 1064 Query: 747 ALCRGWVDTIYNA-QNQLQQLRA------QEPPGSQQPLQ-----SLEEEEDEQEEEEEE 794 + W++ + A +N + A PPG ++P Q S E +D E Sbjct: 1065 SDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEP 1124 Query: 795 EEEEEEG 801 E EE G Sbjct: 1125 EPEELPG 1131 >gi|51972240 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 [Homo sapiens] Length = 379 Score = 101 bits (251), Expect = 4e-21 Identities = 86/363 (23%), Positives = 159/363 (43%), Gaps = 51/363 (14%) Query: 438 LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 497 +F+ L LQ L +V+ RLF+N+ E+ Q S+ + + + + D Sbjct: 2 IFMNTLRYLQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASE-ISSSLD 60 Query: 498 FLKGFKMF--GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLS 555 F+ + GSL + + YC+ + Y+ L R D F Y+ W E++ QC+RL + Sbjct: 61 FISVLTKYFRGSLCQSHQTYCLNYSAAIFYLESL-RQRDDFGIYLKWCEQNEQCRRLHVP 119 Query: 556 DMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRL 615 ++L P QRLT+YPLLLK++ +++ + K + ++ VE+ I + ++ Q+ Sbjct: 120 ELLVAPLQRLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKF 179 Query: 616 AAVVSRIDAYEVVESSS-----DEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM 670 + I + + + + + KE + ++ +P +R LL EG L + Sbjct: 180 RYLQEIIVWPPLWDRDKRFFIPECLKHIFKEHMAENILSP-------TSRHLLYEGKLTL 232 Query: 671 KEGKDSKMDVYCFLFTDLLLVTK--------------------------AVKKAERTRVI 704 E +DVY FLF D LLVTK +K+ V+ Sbjct: 233 AE-STRFLDVYLFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVL 291 Query: 705 RPPLLVDKIVCRELRD--------PGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 756 P+ +D++V + + +FL+ + N + + A+ QA + + + W+ I Sbjct: 292 DQPIPLDRLVVKSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQI 351 Query: 757 YNA 759 A Sbjct: 352 TTA 354 >gi|194473700 Src homology 3 domain-containing guanine nucleotide exchange factor [Homo sapiens] Length = 871 Score = 99.0 bits (245), Expect = 2e-20 Identities = 97/395 (24%), Positives = 180/395 (45%), Gaps = 54/395 (13%) Query: 338 SAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACL----RL 393 S+ GR KM + +G L + + D DS EE +++ D + L Sbjct: 355 SSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKPL 414 Query: 394 EDSWRELIDGHEK-----LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQE 448 +W +L K +++ + +QEA++E++ +E SY+ L ++I +F N +E Sbjct: 415 RSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFK----NSKE 470 Query: 449 -SGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQP-GDFLKGFKMFG 506 S + + E LFSNI ++ + ++ + LE + + D ++ K Sbjct: 471 LSDTMTKTERHHLFSNITDVCEASKKFFIE-----LEARHQNNIFIDDISDIVE--KHTA 523 Query: 507 SLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLT 566 S F PY++YC E ++ LL N F+ ++ E H C+ L + L P QR+T Sbjct: 524 STFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVT 583 Query: 567 KYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYE 626 + PLL+ ++ +KT + K V +R + V+ +R E R +++ E Sbjct: 584 RLPLLMDTICQKTPKDSPKYEV------CKRALKEVSKLVRLCNEGAR------KMERTE 631 Query: 627 VVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLR-------MKEGKDSKMD 679 ++ + + +++ +K F P+ +S R L+ G L + + SK Sbjct: 632 MMYTINSQLEFKIKPF-------PLVSSS----RWLVKRGELTAYVEDTVLFSRRTSKQQ 680 Query: 680 VYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIV 714 VY FLF D+L++TK KK+E + + L D+++ Sbjct: 681 VYFFLFNDVLIITK--KKSEESYNVNDYSLRDQLL 713 >gi|163792208 Rho guanine exchange factor 16 [Homo sapiens] Length = 709 Score = 84.7 bits (208), Expect = 4e-16 Identities = 82/331 (24%), Positives = 151/331 (45%), Gaps = 48/331 (14%) Query: 405 EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 464 ++L+ + +QEA++E+L +E SY L +++ FL + + + ++E LFSNI Sbjct: 276 DQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFL---QSKELRATVTQMEHHHLFSNI 332 Query: 465 PEIAQLHRRLWASVMAPVLEKARRTRALLQP-GDFLKGFKMFGSLFKPYIRYCMEEEGCM 523 ++ +R + LE+ + + L++ D L+ + F PYI YC E Sbjct: 333 LDVLGASQRFFED-----LEQRHKAQVLVEDISDILE--EHAEKHFHPYIAYCSNEVYQQ 385 Query: 524 EYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE-EP 582 ++ L+ N FR + E+ P C L + L P QR+T+ PLL+ ++ KT+ Sbjct: 386 RTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHS 445 Query: 583 RAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEF 642 +A + ++ + + N + + +++ + +++D +V Sbjct: 446 ERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKV--------------- 490 Query: 643 LHLDLTAPIPGASPEETRQLLLEGSLRMKEGKD------SKMDVYCFLFTDLLLVTKAVK 696 + P+ AS R LL G L + E S+ Y FLF D+L+VTK K Sbjct: 491 ----KSLPLISAS----RWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTK--K 540 Query: 697 KAERTRVIRP-----PLLVDKIVCRELRDPG 722 K+E + +++ + V+KI EL PG Sbjct: 541 KSEESYMVQDYAQMNHIQVEKIEPSELPLPG 571 >gi|194294523 intersectin 2 isoform 3 [Homo sapiens] Length = 1670 Score = 83.2 bits (204), Expect = 1e-15 Identities = 85/366 (23%), Positives = 160/366 (43%), Gaps = 47/366 (12%) Query: 414 QQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRR 473 +Q + EL+ TE Y+ L++++ +F + ESG L E E +F N E+ + + Sbjct: 1183 RQGYIHELIQTEERYMADLQLVVEVFQ---KRMAESGFLTEGEMALIFVNWKELIMSNTK 1239 Query: 474 LWASVMAPVLEKARRTRALLQP-GDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRD 532 L ++ V +K + +Q GD L S + YIR+C + ++ + Sbjct: 1240 LLKALR--VRKKTGGEKMPVQMIGDILAAEL---SHMQAYIRFCSCQLNGAALLQQKTDE 1294 Query: 533 NDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAM- 591 + F+ ++ P+C+ + LS L KP QR+T+YPLL++S+L T E A + + + Sbjct: 1295 DTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLA 1354 Query: 592 IGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPI 651 + E VN +R+++ RL + + + + + L ++ + LT + Sbjct: 1355 LERAEELCSQVNEGVREKENSDRLEWIQAHV-----------QCEGLAEQLIFNSLTNCL 1403 Query: 652 PGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKK-------------- 697 R+LL G L + S +++ FLF D LL+T VK+ Sbjct: 1404 ------GPRKLLHSGKLYKTK---SNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSK 1454 Query: 698 -AERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 756 + ++ + P+ +++++ + DP S ++ V YT + WV I Sbjct: 1455 SNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRV--YTLRTDNINERTAWVQKI 1512 Query: 757 YNAQNQ 762 A Q Sbjct: 1513 KAASEQ 1518 >gi|194294521 intersectin 2 isoform 1 [Homo sapiens] Length = 1697 Score = 83.2 bits (204), Expect = 1e-15 Identities = 85/366 (23%), Positives = 160/366 (43%), Gaps = 47/366 (12%) Query: 414 QQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRR 473 +Q + EL+ TE Y+ L++++ +F + ESG L E E +F N E+ + + Sbjct: 1210 RQGYIHELIQTEERYMADLQLVVEVFQ---KRMAESGFLTEGEMALIFVNWKELIMSNTK 1266 Query: 474 LWASVMAPVLEKARRTRALLQP-GDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRD 532 L ++ V +K + +Q GD L S + YIR+C + ++ + Sbjct: 1267 LLKALR--VRKKTGGEKMPVQMIGDILAAEL---SHMQAYIRFCSCQLNGAALLQQKTDE 1321 Query: 533 NDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAM- 591 + F+ ++ P+C+ + LS L KP QR+T+YPLL++S+L T E A + + + Sbjct: 1322 DTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLA 1381 Query: 592 IGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPI 651 + E VN +R+++ RL + + + + + L ++ + LT + Sbjct: 1382 LERAEELCSQVNEGVREKENSDRLEWIQAHV-----------QCEGLAEQLIFNSLTNCL 1430 Query: 652 PGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKK-------------- 697 R+LL G L + S +++ FLF D LL+T VK+ Sbjct: 1431 ------GPRKLLHSGKLYKTK---SNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSK 1481 Query: 698 -AERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 756 + ++ + P+ +++++ + DP S ++ V YT + WV I Sbjct: 1482 SNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRV--YTLRTDNINERTAWVQKI 1539 Query: 757 YNAQNQ 762 A Q Sbjct: 1540 KAASEQ 1545 >gi|166197690 neuronal guanine nucleotide exchange factor isoform 2 [Homo sapiens] Length = 618 Score = 82.0 bits (201), Expect = 3e-15 Identities = 98/419 (23%), Positives = 173/419 (41%), Gaps = 71/419 (16%) Query: 374 DSWEEEYDEDEDEDNA-----------CLRLE-----DSWRELIDGH-----EKLTRRQC 412 D+ EEE +E+E+E+ A CL + W++L + E L + Sbjct: 121 DTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEI 180 Query: 413 HQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHR 472 QEA++EL+ +EASY + L ++++ F+ N + +L EA LFSN+ ++ + Sbjct: 181 KLQEAMFELVTSEASYYKSLNLLVSHFM---ENERIRKILHPSEAHILFSNVLDVLAVSE 237 Query: 473 RLWASVMAPVLEKARRTRALLQPGDFLK-GFKMFGSLFKPYIRYCMEEEGCMEYMRGLLR 531 R +LE R + D ++ F YI Y + + LL+ Sbjct: 238 RF-------LLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQ 290 Query: 532 DNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAM 591 + FR I E P+C+ L S L P QR+T+ LL++++L++ EE +E Sbjct: 291 EKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTA-- 348 Query: 592 IGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPI 651 + + + V AC ++ R ++S + K+ + PI Sbjct: 349 LDAHKELEMVVKACNEGVRKMSRTEQMIS-----------------IQKKMEFKIKSVPI 391 Query: 652 PGASPEETRQLLLEGSLRMKEGKDSKM---------DVYCFLFTDLLLVTKAVKKAERTR 702 S R LL +G L+ G + ++Y FLF DLL++ + + + Sbjct: 392 ISHS----RWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQV 447 Query: 703 VIRPPLLVDKIVCRELRDPGS-----FLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 756 P + ++ EL D G F+L L Y +AS Q+ + W+ ++ Sbjct: 448 FDSAPRGLLRV--EELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL 504 Score = 31.6 bits (70), Expect = 4.2 Identities = 18/45 (40%), Positives = 24/45 (53%), Gaps = 2/45 (4%) Query: 757 YNAQNQLQQL--RAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEE 799 Y ++ LQ++ R Q+ + ED EEEEEEEEEEE Sbjct: 90 YRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEE 134 >gi|166197688 neuronal guanine nucleotide exchange factor isoform 1 [Homo sapiens] Length = 710 Score = 82.0 bits (201), Expect = 3e-15 Identities = 98/419 (23%), Positives = 173/419 (41%), Gaps = 71/419 (16%) Query: 374 DSWEEEYDEDEDEDNA-----------CLRLE-----DSWRELIDGH-----EKLTRRQC 412 D+ EEE +E+E+E+ A CL + W++L + E L + Sbjct: 213 DTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEI 272 Query: 413 HQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHR 472 QEA++EL+ +EASY + L ++++ F+ N + +L EA LFSN+ ++ + Sbjct: 273 KLQEAMFELVTSEASYYKSLNLLVSHFM---ENERIRKILHPSEAHILFSNVLDVLAVSE 329 Query: 473 RLWASVMAPVLEKARRTRALLQPGDFLK-GFKMFGSLFKPYIRYCMEEEGCMEYMRGLLR 531 R +LE R + D ++ F YI Y + + LL+ Sbjct: 330 RF-------LLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQ 382 Query: 532 DNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAM 591 + FR I E P+C+ L S L P QR+T+ LL++++L++ EE +E Sbjct: 383 EKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTA-- 440 Query: 592 IGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPI 651 + + + V AC ++ R ++S + K+ + PI Sbjct: 441 LDAHKELEMVVKACNEGVRKMSRTEQMIS-----------------IQKKMEFKIKSVPI 483 Query: 652 PGASPEETRQLLLEGSLRMKEGKDSKM---------DVYCFLFTDLLLVTKAVKKAERTR 702 S R LL +G L+ G + ++Y FLF DLL++ + + + Sbjct: 484 ISHS----RWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQV 539 Query: 703 VIRPPLLVDKIVCRELRDPGS-----FLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 756 P + ++ EL D G F+L L Y +AS Q+ + W+ ++ Sbjct: 540 FDSAPRGLLRV--EELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL 596 Score = 31.6 bits (70), Expect = 4.2 Identities = 18/45 (40%), Positives = 24/45 (53%), Gaps = 2/45 (4%) Query: 757 YNAQNQLQQL--RAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEE 799 Y ++ LQ++ R Q+ + ED EEEEEEEEEEE Sbjct: 182 YRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEE 226 >gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] Length = 1721 Score = 79.7 bits (195), Expect = 1e-14 Identities = 75/303 (24%), Positives = 136/303 (44%), Gaps = 48/303 (15%) Query: 405 EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 464 + LT + +Q + EL+ TE +Y+ L+++ +F L+ ES LL E E +F N Sbjct: 1229 DMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLM---ESELLTEKEVAMIFVNW 1285 Query: 465 PEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLF-------KPYIRYCM 517 E+ + +L KA R R + G+ + KM G + +PYIR+C Sbjct: 1286 KELIMCNIKLL---------KALRVRKKMS-GEKMP-VKMIGDILSAQLPHMQPYIRFCS 1334 Query: 518 EEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLR 577 + ++ + F+ ++ P+C+ + LS + KP QR+T+YPL++K++L Sbjct: 1335 RQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILE 1394 Query: 578 KTEEPRAKEA-VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVES-SSDEV 635 T E + + + E VN +R+++ RL + + + + E + V Sbjct: 1395 NTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSV 1454 Query: 636 DKLL--KEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK 693 L ++FLH S ++ + K +K ++Y FLF D LL+T+ Sbjct: 1455 TNCLGPRKFLH----------------------SGKLYKAKSNK-ELYGFLFNDFLLLTQ 1491 Query: 694 AVK 696 K Sbjct: 1492 ITK 1494 >gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens] Length = 2817 Score = 78.6 bits (192), Expect = 3e-14 Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%) Query: 395 DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 450 +SW +ID K ++Q +QE ++EL+ TE ++R L+++ ++ ++ + Sbjct: 1978 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 2031 Query: 451 LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 505 LL E + E+LF + E+ +H + + ++ +++K+ + + + GD L + Sbjct: 2032 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 2090 Query: 506 GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 561 G L K Y ++C + + Y + L + F+A++ +RL + + + Sbjct: 2091 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 2150 Query: 562 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 620 QR+TKYP+L + +L+ T++ ++ +A + V+ I V++ + +++ RL + + Sbjct: 2151 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 2210 Query: 621 RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 680 + D+ ++ S ++ F DL + ++L+ +GS+ +K +V Sbjct: 2211 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 2254 Query: 681 YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 733 L TD+L+ + + +++ VI L+ + V E + G FL+ Sbjct: 2255 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 2312 Query: 734 SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 793 V + AS + W+ I Q + +L +EDE E Sbjct: 2313 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 2351 Query: 794 EEEEE 798 EEE++ Sbjct: 2352 EEEKK 2356 >gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens] Length = 1058 Score = 78.6 bits (192), Expect = 3e-14 Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%) Query: 395 DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 450 +SW +ID K ++Q +QE ++EL+ TE ++R L+++ ++ ++ + Sbjct: 219 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 272 Query: 451 LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 505 LL E + E+LF + E+ +H + + ++ +++K+ + + + GD L + Sbjct: 273 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 331 Query: 506 GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 561 G L K Y ++C + + Y + L + F+A++ +RL + + + Sbjct: 332 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 391 Query: 562 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 620 QR+TKYP+L + +L+ T++ ++ +A + V+ I V++ + +++ RL + + Sbjct: 392 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 451 Query: 621 RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 680 + D+ ++ S ++ F DL + ++L+ +GS+ +K +V Sbjct: 452 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 495 Query: 681 YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 733 L TD+L+ + + +++ VI L+ + V E + G FL+ Sbjct: 496 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 553 Query: 734 SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 793 V + AS + W+ I Q + +L +EDE E Sbjct: 554 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 592 Query: 794 EEEEE 798 EEE++ Sbjct: 593 EEEKK 597 >gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens] Length = 2813 Score = 78.6 bits (192), Expect = 3e-14 Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%) Query: 395 DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 450 +SW +ID K ++Q +QE ++EL+ TE ++R L+++ ++ ++ + Sbjct: 1974 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 2027 Query: 451 LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 505 LL E + E+LF + E+ +H + + ++ +++K+ + + + GD L + Sbjct: 2028 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 2086 Query: 506 GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 561 G L K Y ++C + + Y + L + F+A++ +RL + + + Sbjct: 2087 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 2146 Query: 562 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 620 QR+TKYP+L + +L+ T++ ++ +A + V+ I V++ + +++ RL + + Sbjct: 2147 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 2206 Query: 621 RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 680 + D+ ++ S ++ F DL + ++L+ +GS+ +K +V Sbjct: 2207 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 2250 Query: 681 YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 733 L TD+L+ + + +++ VI L+ + V E + G FL+ Sbjct: 2251 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 2308 Query: 734 SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 793 V + AS + W+ I Q + +L +EDE E Sbjct: 2309 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 2347 Query: 794 EEEEE 798 EEE++ Sbjct: 2348 EEEKK 2352 >gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Homo sapiens] Length = 802 Score = 78.2 bits (191), Expect = 4e-14 Identities = 73/288 (25%), Positives = 127/288 (44%), Gaps = 25/288 (8%) Query: 407 LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 466 L+ R C QEA +EL+ +EASYI L V + FL + + S L + + LFS +PE Sbjct: 370 LSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLG---SAELSECLGAQDKQWLFSKLPE 426 Query: 467 IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYM 526 + R + + R D F+ ++ PY+ +E Y Sbjct: 427 VKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRR---VYLPYVTNQAYQE--RTYQ 481 Query: 527 RGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKE 586 R LL +N F + E+ P CQRL L+ L P QR+T+ +L++++L++T + E Sbjct: 482 R-LLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDE 540 Query: 587 AVVA-MIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHL 645 + +++ + NA ++ + + L + +I + + L++ + Sbjct: 541 DMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELV 600 Query: 646 DLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK 693 +L AP+P A P + K S VY LF D LL+++ Sbjct: 601 EL-APLPAAPPAKL--------------KLSSKAVYLHLFNDCLLLSR 633 >gi|32307166 Rho guanine exchange factor 15 [Homo sapiens] Length = 841 Score = 77.4 bits (189), Expect = 7e-14 Identities = 56/224 (25%), Positives = 113/224 (50%), Gaps = 10/224 (4%) Query: 405 EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 464 + L+ ++ QE+++E++ +EASY+R LR++ + F+ L+ L + LFSN+ Sbjct: 409 DTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFV---LSQALRDTLTPRDHHTLFSNV 465 Query: 465 PEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCME 524 + + R +A +L + R + + D + + F Y+ Y ++ E Sbjct: 466 QRVQGVSERF----LATLLSRVRSSPHISDLCDVVHAHAV--GPFSVYVDYVRNQQYQEE 519 Query: 525 YMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRA 584 L+ N F A + + P+C+RL L L P QR+T+ +LL+++LR+TEE + Sbjct: 520 TYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSS 579 Query: 585 K-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEV 627 + E +G+V + I +A + + ++ + L + R+ ++V Sbjct: 580 RQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKV 623 Score = 35.0 bits (79), Expect = 0.38 Identities = 55/214 (25%), Positives = 76/214 (35%), Gaps = 25/214 (11%) Query: 856 PFSSQSDETSLSTTASSATPTSELLP--LGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPM 913 P +S T + T P + L P L P S+DS SP+S P P+ Sbjct: 47 PRNSNDAPTPMCTPIFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTP---TPSPV 103 Query: 914 AELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAG---AGTHG 970 + +PR P PPP P TP+ ++ S S ++ LAG G G Sbjct: 104 SRRSASPEPAPRSPVPPPKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEG 163 Query: 971 ---TPSAPSRSL-------SELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVG 1020 AP L E + G + G+P C + PGL Sbjct: 164 RAQDADAPEPGLQARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLE- 222 Query: 1021 CLAGEPAGSHRKRCGDLPSGASP----RVQPEPP 1050 L P G + + +P ASP R +P PP Sbjct: 223 -LRWVPVGGY-EEVPRVPRRASPLRTSRSRPHPP 254 >gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 [Homo sapiens] Length = 596 Score = 77.0 bits (188), Expect = 9e-14 Identities = 103/414 (24%), Positives = 170/414 (41%), Gaps = 67/414 (16%) Query: 397 WRELID--GHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCE 454 W E++D E LT R+ +QEA++E+ E I L++ + +L L ++ E Sbjct: 156 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLS---IMSE 212 Query: 455 VEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIR 514 E +F ++ LH L + + E + + Q G L + + ++ Y Sbjct: 213 EELTHIFGDLDSYIPLHEDL----LTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCS 268 Query: 515 YCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKS 574 + + ++ + R D + + + P ++L L L P RL KYPLLLK Sbjct: 269 NQLAAKALLDQKKQDPRVQDFLQRCL----ESPFSRKLDLWSFLDIPRSRLVKYPLLLKE 324 Query: 575 VLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDE 634 +L+ T P+ V + ++ + V+S I+ + Sbjct: 325 ILKHT--PKEHPDVQLLEDAI-----------------LIIQGVLSDINLKKGESECQYY 365 Query: 635 VDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKA 694 +DKL E+L P E ++ LL G LR K G +Y FLF D+L++T+ Sbjct: 366 IDKL--EYLDEKQRDP----RIEASKVLLCHGELRSKSGH----KLYIFLFQDILVLTRP 415 Query: 695 VKKAER--TRVIRPPLLVDKIVCRELRD-----PGSFLLIYLN----------EFH--SA 735 V + ER +V R P+ V ++V +L+D GSF + N FH S Sbjct: 416 VTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSP 475 Query: 736 VGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQE 789 ++T QA+ + W + I A Q GS LQ L E +E E Sbjct: 476 AQSHTLQANDVFHKQQWFNCIRAAIAPFQS------AGSPPELQGLPELHEECE 523 >gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2 [Homo sapiens] Length = 985 Score = 72.8 bits (177), Expect = 2e-12 Identities = 116/542 (21%), Positives = 213/542 (39%), Gaps = 109/542 (20%) Query: 395 DSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLL 452 DSW +D ++ + QQ+ ++EL+ TE ++R L+++ LF +G+L Sbjct: 214 DSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLF--------RTGML 265 Query: 453 CEVEAER-----LFSNIPEIAQLHRRLWASVMAPVLEKAR--------RTRALLQPGDFL 499 E+ E LF + E++ +H R ++ +LE+ R R + + GD L Sbjct: 266 EELHLEPGVVQGLFPCVDELSDIHTRF----LSQLLERRRQALCPGSTRNFVIHRLGDLL 321 Query: 500 KGFKMFGS-----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKL 554 F + K Y +C ++ + L + F+ +I + +R + Sbjct: 322 --ISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGV 379 Query: 555 SDMLAKPHQRLTKYPLLLKSVLRKT---EEPRAKEAVVAMIGSVERFIHHVNACMRQRQE 611 + + QR+TKYPLL+ +L+ + EE R + + +G V+ + +V+ + Q ++ Sbjct: 380 QECILLVTQRITKYPLLISRILQHSHGIEEER--QDLTTALGLVKELLSNVDEGIYQLEK 437 Query: 612 RQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASP---EE--TRQLLLEG 666 RL + +R+D P+PG P EE R+L+ +G Sbjct: 438 GARLQEIYNRMDP---------------------RAQTPVPGKGPFGREELLRRKLIHDG 476 Query: 667 SLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLV--DKIVCREL--RDPG 722 L K DV L TD+L+ + + + P +V ++ R++ ++ G Sbjct: 477 CLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKG 536 Query: 723 SFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLE 782 FL+ + Y + + W+ I QQ P PL E Sbjct: 537 MFLI-----SAAPPEMYEVHTASRDDRSTWIRVI-------QQSVRTCPSREDFPLIETE 584 Query: 783 EEEDEQEEEEEEEEEEE-------------------EGEDSGTSAASSPTIMR-----KS 818 +E + + E ++++ + E+ G S + PT+ R +S Sbjct: 585 DEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSES 644 Query: 819 SGSPDSQHCASDG--STETLAMVVVEPG-DTLSSPEFDSGPFSSQS-DETSLSTTASSAT 874 SP + D E L ++V PG + L +P + P S TS TA+ Sbjct: 645 LESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEA 704 Query: 875 PT 876 T Sbjct: 705 RT 706 >gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1 [Homo sapiens] Length = 986 Score = 72.8 bits (177), Expect = 2e-12 Identities = 116/542 (21%), Positives = 213/542 (39%), Gaps = 109/542 (20%) Query: 395 DSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLL 452 DSW +D ++ + QQ+ ++EL+ TE ++R L+++ LF +G+L Sbjct: 215 DSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLF--------RTGML 266 Query: 453 CEVEAER-----LFSNIPEIAQLHRRLWASVMAPVLEKAR--------RTRALLQPGDFL 499 E+ E LF + E++ +H R ++ +LE+ R R + + GD L Sbjct: 267 EELHLEPGVVQGLFPCVDELSDIHTRF----LSQLLERRRQALCPGSTRNFVIHRLGDLL 322 Query: 500 KGFKMFGS-----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKL 554 F + K Y +C ++ + L + F+ +I + +R + Sbjct: 323 --ISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGV 380 Query: 555 SDMLAKPHQRLTKYPLLLKSVLRKT---EEPRAKEAVVAMIGSVERFIHHVNACMRQRQE 611 + + QR+TKYPLL+ +L+ + EE R + + +G V+ + +V+ + Q ++ Sbjct: 381 QECILLVTQRITKYPLLISRILQHSHGIEEER--QDLTTALGLVKELLSNVDEGIYQLEK 438 Query: 612 RQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASP---EE--TRQLLLEG 666 RL + +R+D P+PG P EE R+L+ +G Sbjct: 439 GARLQEIYNRMDP---------------------RAQTPVPGKGPFGREELLRRKLIHDG 477 Query: 667 SLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLV--DKIVCREL--RDPG 722 L K DV L TD+L+ + + + P +V ++ R++ ++ G Sbjct: 478 CLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKG 537 Query: 723 SFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLE 782 FL+ + Y + + W+ I QQ P PL E Sbjct: 538 MFLI-----SAAPPEMYEVHTASRDDRSTWIRVI-------QQSVRTCPSREDFPLIETE 585 Query: 783 EEEDEQEEEEEEEEEEE-------------------EGEDSGTSAASSPTIMR-----KS 818 +E + + E ++++ + E+ G S + PT+ R +S Sbjct: 586 DEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSES 645 Query: 819 SGSPDSQHCASDG--STETLAMVVVEPG-DTLSSPEFDSGPFSSQS-DETSLSTTASSAT 874 SP + D E L ++V PG + L +P + P S TS TA+ Sbjct: 646 LESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEA 705 Query: 875 PT 876 T Sbjct: 706 RT 707 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.132 0.392 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 50,609,102 Number of Sequences: 37866 Number of extensions: 2927472 Number of successful extensions: 52720 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 706 Number of HSP's successfully gapped in prelim test: 860 Number of HSP's that attempted gapping in prelim test: 28233 Number of HSP's gapped (non-prelim): 14202 length of query: 1083 length of database: 18,247,518 effective HSP length: 113 effective length of query: 970 effective length of database: 13,968,660 effective search space: 13549600200 effective search space used: 13549600200 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.5 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.